      
      <110> Tang, Y. Tom
	    Wang, Jian-rui
	    Zhang, Jie
	    Ren, Feiyan
	    Zhou, Ping
	    Ma, Yunqing
	    Ghosh, Malabika
	    Xue, Aidong J.
	    Asundi, Vinod
	    Zhao, Qing A.
	    Wang, Dunrui
	    Goodrich, Ryle W.
	    Chen, Rui-hong
	    Wehrman, Tom
	    Weng, Gezhi
	    Wang, Zhiwei
	    Boyle, Bryan J.
	    Drmanac, Radoje T.

      <120> Novel Nucleic Acids and Polypeptides

      <130> 822CIP/PCT

      <140> Not yet assigned
      <141> 2004-03-11

      <150> US 10/389,559
      <151> 2003-03-14

      <150> US 60/365,264
      <151> 2002-03-14

      <150> US 60/340,187
      <151> 2001-12-12

      <150> US 10/296,115
      <151> 2000-12-22

      <150> PCT/US00/35017
      <151> 2000-12-22

      <150> US 09/552,317
      <151> 2000-04-25

      <150> US 09/488,725
      <151> 2000-01-21

      <150> US 10/275,027
      <151> 2001-01-25

      <150> PCT/US01/02623
      <151> 2001-01-25

      <150> US 09/491,404
      <151> 2000-01-25

      <150> US 10/276,774
      <151> 2001-02-05

      <150> PCT/US01/03800
      <151> 2001-02-05

      <150> US 09/560,875
      <151> 2000-04-27

      <150> US 09/496,914
      <151> 2000-02-03

      <150> US 10/220,366
      <151> 2001-02-26

      <150> PCT/US01/04927
      <151> 2001-02-26

      <150> US 09/577,409
      <151> 2000-05-18

      <150> US 09/515,126
      <151> 2000-02-28

      <150> US 10/221,279
      <151> 2001-03-05

      <150> PCT/US01/04941
      <151> 2001-03-05

      <150> US 09/574,454
      <151> 2000-05-19

      <150> US 09/519,705
      <151> 2000-03-07

      <150> US 10/450,763
      <151> 2001-03-30

      <150> PCT/US01/08631
      <151> 2001-03-30

      <150> US 09/649,167
      <151> 2000-08-23

      <150> US 09/540,217
      <151> 2000-03-31

      <150> PCT/US01/08656
      <151> 2001-04-18

      <150> US 09/770,160
      <151> 2001-01-26

      <150> US 09/552,929
      <151> 2000-04-18

      <150> US 10/276,817
      <151> 2001-05-16

      <150> PCT/US01/14827
      <151> 2001-05-16

      <150> US 09/577,408
      <151> 2000-05-18

      <160> 1920

      <170> pt_FL_genes Version 6.0




      <210> 1
      <211> 1545
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (299)..(1300)

      <220>
      <221> misc_feature
      <222> (1)...(1545)
      <223> n = a,t,c or g

      <400> 1
 ggcctgtcct ggcctctgag agtgggatgg ttggtgctgt acctcagggg acagggcggg     60

 gcgggaggag gcggggccag gcctggtctc tgataacggg atgggtggtg ctggacctcg    120

 ggcggggccg ggcctcgtgg cgggaggagg cagggcaggg cctctgggac ggggctggac    180

 ggcttgttga cggaaacgag cccttgacgc tgtggcccgg aagtggagcg gctgtcgcag    240

 tgcggctccg gcagtggcag cggaggcctg tgtttgcggc cttcggcaag cgactgag      298                                                                 
 atg gcg agc gca act gca cct gca gcc gca gtc ccc acc ctg gct tcg      346
 Met Ala Ser Ala Thr Ala Pro Ala Ala Ala Val Pro Thr Leu Ala Ser
   1               5                  10                  15

 cct ttg gag cag ctc cgg cac ttg gcg gag gag ctg cgg ttg ctc ctg      394
 Pro Leu Glu Gln Leu Arg His Leu Ala Glu Glu Leu Arg Leu Leu Leu
              20                  25                  30

 cct cga gtg cgg gtc ggc gaa gcc cag gag acc acc gag gag ttt aat      442
 Pro Arg Val Arg Val Gly Glu Ala Gln Glu Thr Thr Glu Glu Phe Asn
          35                  40                  45

 cga gag atg ttc tgg aga aga ctc aat gag gca gct gtg act gtg tca      490
 Arg Glu Met Phe Trp Arg Arg Leu Asn Glu Ala Ala Val Thr Val Ser
      50                  55                  60

 agg gaa gcc acg act ctg acc ata gtc ttc tct cag ctt cca ctg ccg      538
 Arg Glu Ala Thr Thr Leu Thr Ile Val Phe Ser Gln Leu Pro Leu Pro
  65                  70                  75                  80

 tct cca cag gaa acc cag aag ttc tgt gaa caa gtc cat gct gcc atc      586
 Ser Pro Gln Glu Thr Gln Lys Phe Cys Glu Gln Val His Ala Ala Ile
                  85                  90                  95

 aag gca ttt att gca gtg tac tat ttg ctt cca aag gat cag ggg atc      634
 Lys Ala Phe Ile Ala Val Tyr Tyr Leu Leu Pro Lys Asp Gln Gly Ile
             100                 105                 110

 acc ctg aga aag ctg gta cgg ggc gcc acc ctg gac atc gtg gat ggc      682
 Thr Leu Arg Lys Leu Val Arg Gly Ala Thr Leu Asp Ile Val Asp Gly
         115                 120                 125

 atg gct cag ctc atg gaa gta ctt tcc gtc act cca act cag agc cct      730
 Met Ala Gln Leu Met Glu Val Leu Ser Val Thr Pro Thr Gln Ser Pro
     130                 135                 140

 gag aac aat gac ctt att tcc tac aac agt gtc tgg gtt gcg tgc cag      778
 Glu Asn Asn Asp Leu Ile Ser Tyr Asn Ser Val Trp Val Ala Cys Gln
 145                 150                 155                 160

 cag atg cct cag ata cca aga gat aac aaa gct gca gct ctt ttg atg      826
 Gln Met Pro Gln Ile Pro Arg Asp Asn Lys Ala Ala Ala Leu Leu Met
                 165                 170                 175

 ctg acc aag aat gtg gat ttt gtg aag gat gca cat gaa gaa atg gag      874
 Leu Thr Lys Asn Val Asp Phe Val Lys Asp Ala His Glu Glu Met Glu
             180                 185                 190

 cag gct gtg gaa gaa tgt gac cct tac tct ggc ctc ttg aat gat act      922
 Gln Ala Val Glu Glu Cys Asp Pro Tyr Ser Gly Leu Leu Asn Asp Thr
         195                 200                 205

 gag gag aac aac tct gac aac cac aat cat gag gat gat gtg ttg ggg      970
 Glu Glu Asn Asn Ser Asp Asn His Asn His Glu Asp Asp Val Leu Gly
     210                 215                 220

 ttt ccc agc aat cag gac ttg tat tgg tca gag gac gat caa gag ctc     1018
 Phe Pro Ser Asn Gln Asp Leu Tyr Trp Ser Glu Asp Asp Gln Glu Leu
 225                 230                 235                 240

 ata atc cca tgc ctt gcg ctg gtg aga gca tcc aaa gcc tgc ctg aag     1066
 Ile Ile Pro Cys Leu Ala Leu Val Arg Ala Ser Lys Ala Cys Leu Lys
                 245                 250                 255

 aaa att cgg atg tta gtg gca gag aat ggg aag aag gat cag gtg gca     1114
 Lys Ile Arg Met Leu Val Ala Glu Asn Gly Lys Lys Asp Gln Val Ala
             260                 265                 270

 cag ctg gat gac att ggg gat att tct gat gaa atc agc cct agt gtg     1162
 Gln Leu Asp Asp Ile Gly Asp Ile Ser Asp Glu Ile Ser Pro Ser Val
         275                 280                 285

 gat gat ttg gct ctg agc ata tat cca cct atg tgt cac ctg acc gtg     1210
 Asp Asp Leu Ala Leu Ser Ile Tyr Pro Pro Met Cys His Leu Thr Val
     290                 295                 300

 cga atc aat gta agt act ggc ttt gag gga ata gct aca gaa caa atg     1258
 Arg Ile Asn Val Ser Thr Gly Phe Glu Gly Ile Ala Thr Glu Gln Met
 305                 310                 315                 320

 ggc aga att tca cta atc act agt att tcc tgt aag cta tag ggtacat     1307
 Gly Arg Ile Ser Leu Ile Thr Ser Ile Ser Cys Lys Leu 
                 325                 330

 atttattagt cacatttgga tggaagtaca acagtaatgt cacagttctt gcatgcgttt   1367

 ggggttgata aatattcact gaagttgaat tataatagcc atgagctttg gtaagttctc   1427

 tcttccataa tcacctgggt aatcattcag aaaaagccca aaggccttag aaaatgatgc   1487

 tttaagggct gggcgcggta nttcacacct ggtaaatccc agcactccag gaaggcgg     1545




      <210> 2
      <211> 780
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (70)..(780)

      <400> 2
 gcacggcggc acgagaggcg gcgcgtggtc tacgccgagt gacagagacg ctcaggctgt     60

 gttctcagg    atg acc gag tgg gag aca gca gca cca gcg gtg gca gag     108
              Met Thr Glu Trp Glu Thr Ala Ala Pro Ala Val Ala Glu
                1               5                  10

 acc cca gac atc aag ctc ttt ggg aag tgg agc acc gat gat gtg cag      156
 Thr Pro Asp Ile Lys Leu Phe Gly Lys Trp Ser Thr Asp Asp Val Gln
      15                  20                  25

 atc aat gac att tcc ctg cag gat tac att gca gtg aag gag aag tat      204
 Ile Asn Asp Ile Ser Leu Gln Asp Tyr Ile Ala Val Lys Glu Lys Tyr
  30                  35                  40                  45

 gcc aag tac ctg cct cac agt gca ggg cgg tat gcc gcc aaa cgc ttc      252
 Ala Lys Tyr Leu Pro His Ser Ala Gly Arg Tyr Ala Ala Lys Arg Phe
                  50                  55                  60

 cgc aaa gct cag tgt ccc att gtg gag cgc ctc act aac tcc atg atg      300
 Arg Lys Ala Gln Cys Pro Ile Val Glu Arg Leu Thr Asn Ser Met Met
              65                  70                  75

 atg cac ggc cgc aac aac ggc aag aag ctc atg act gtg cgc atc gtc      348
 Met His Gly Arg Asn Asn Gly Lys Lys Leu Met Thr Val Arg Ile Val
          80                  85                  90

 aag cat gcc ttc gag atc ata cac ctg ctc aca ggc gag aac cct ctg      396
 Lys His Ala Phe Glu Ile Ile His Leu Leu Thr Gly Glu Asn Pro Leu
      95                 100                 105

 cag gtc ctg gtg aac gcc atc atc aac agt ggt ccc cgg gag gac tcc      444
 Gln Val Leu Val Asn Ala Ile Ile Asn Ser Gly Pro Arg Glu Asp Ser
 110                 115                 120                 125

 aca cgc att ggg tgc gcc ggg act gtg aga cga cag gct gtg gac gtg      492
 Thr Arg Ile Gly Cys Ala Gly Thr Val Arg Arg Gln Ala Val Asp Val
                 130                 135                 140

 tcc cca ctt cgc cgt gtg aat cag gcc atc tgg ctg ctg tgc aca ggt      540
 Ser Pro Leu Arg Arg Val Asn Gln Ala Ile Trp Leu Leu Cys Thr Gly
             145                 150                 155

 gct cgt gag gct gcc ttc cgg aac att aag acc att gat gag tgc ctg      588
 Ala Arg Glu Ala Ala Phe Arg Asn Ile Lys Thr Ile Asp Glu Cys Leu
         160                 165                 170

 gca gag gag ctc atc aat gct gcc aag ggc tcc tcc aac tcc tat gcc      636
 Ala Glu Glu Leu Ile Asn Ala Ala Lys Gly Ser Ser Asn Ser Tyr Ala
     175                 180                 185

 att aag aag aag gac gtg tgg cct tct tgg agc atg tgg cca agt cca      684
 Ile Lys Lys Lys Asp Val Trp Pro Ser Trp Ser Met Trp Pro Ser Pro
 190                 195                 200                 205

 acc gct gat ttt ccc agc tgt tgc cca ata aac ctg tct gcc ctt cag      732
 Thr Ala Asp Phe Pro Ser Cys Cys Pro Ile Asn Leu Ser Ala Leu Gln
                 210                 215                 220

 ggc agc cct acc aaa aaa agc aaa aaa att aca act aag tta tta taa      780
 Gly Ser Pro Thr Lys Lys Ser Lys Lys Ile Thr Thr Lys Leu Leu 
             225                 230                 235





      <210> 3
      <211> 4222
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (12)..(3743)

      <400> 3
 ctgagcggat c atg tgg ccc gag ttg acg ggc tcc ccg gtg cgc ggg tgc      50
              Met Trp Pro Glu Leu Thr Gly Ser Pro Val Arg Gly Cys
                1               5                  10

 agc cag gtc gtg cag cgg agc tgg tca atg gcg gcg gcg acg gtc ggg       98
 Ser Gln Val Val Gln Arg Ser Trp Ser Met Ala Ala Ala Thr Val Gly
      15                  20                  25

 cgg gac act tta cct gag cat tgg tcc tac ggg gtg tgc cgg gat ggc      146
 Arg Asp Thr Leu Pro Glu His Trp Ser Tyr Gly Val Cys Arg Asp Gly
  30                  35                  40                  45

 cgc gtc ttc ttc atc aat gac cag ctc cgc tgc acg acc tgg ctg cac      194
 Arg Val Phe Phe Ile Asn Asp Gln Leu Arg Cys Thr Thr Trp Leu His
                  50                  55                  60

 ccg cgc acc ggg gag ccc gtc aac tcg ggc cac atg atc cgc tca gac      242
 Pro Arg Thr Gly Glu Pro Val Asn Ser Gly His Met Ile Arg Ser Asp
              65                  70                  75

 ctg ccc cgc ggc tgg gag gag ggc ttc acg gag gag ggc gcc agc tac      290
 Leu Pro Arg Gly Trp Glu Glu Gly Phe Thr Glu Glu Gly Ala Ser Tyr
          80                  85                  90

 ttc atc gac cat aac cag cag acc aca gca ttc agg cat cct gtg acg      338
 Phe Ile Asp His Asn Gln Gln Thr Thr Ala Phe Arg His Pro Val Thr
      95                 100                 105

 gga cag ttt tct cca gaa aat agt gaa ttc att ctt caa gaa gag ccg      386
 Gly Gln Phe Ser Pro Glu Asn Ser Glu Phe Ile Leu Gln Glu Glu Pro
 110                 115                 120                 125

 aat cca cat atg tcg aag caa gac aga aac caa aga ccg tcc agc atg      434
 Asn Pro His Met Ser Lys Gln Asp Arg Asn Gln Arg Pro Ser Ser Met
                 130                 135                 140

 gtc agt gaa aca tcc acg gct ggg acc gcc tcc acc ctg gag gcc aag      482
 Val Ser Glu Thr Ser Thr Ala Gly Thr Ala Ser Thr Leu Glu Ala Lys
             145                 150                 155

 cct gga ccc aag atc ata aag tcc agc agt aaa gtc cac agc ttt ggg      530
 Pro Gly Pro Lys Ile Ile Lys Ser Ser Ser Lys Val His Ser Phe Gly
         160                 165                 170

 aag aga gac cag gcc att cgg agg aac ccc aat gtt ccc gtg gtg gtg      578
 Lys Arg Asp Gln Ala Ile Arg Arg Asn Pro Asn Val Pro Val Val Val
     175                 180                 185

 agg ggc tgg ctg cac aag cag gac agt tct ggg atg agg ctg tgg aaa      626
 Arg Gly Trp Leu His Lys Gln Asp Ser Ser Gly Met Arg Leu Trp Lys
 190                 195                 200                 205

 agg agg tgg ttt gtg ctt gct gat tac tgc tta ttt tac tat aaa gac      674
 Arg Arg Trp Phe Val Leu Ala Asp Tyr Cys Leu Phe Tyr Tyr Lys Asp
                 210                 215                 220

 agc cga gaa gaa gcg gtc ctc ggg agc atc ccc ttg ccc agc tac gtg      722
 Ser Arg Glu Glu Ala Val Leu Gly Ser Ile Pro Leu Pro Ser Tyr Val
             225                 230                 235

 atc tct cct gtg gcc cct gag gat cgc ata agc cgc aaa tat tcc ttt      770
 Ile Ser Pro Val Ala Pro Glu Asp Arg Ile Ser Arg Lys Tyr Ser Phe
         240                 245                 250

 aag gct gtg cac acg ggg atg cga gcg ctc atc tat aac agc tcc aca      818
 Lys Ala Val His Thr Gly Met Arg Ala Leu Ile Tyr Asn Ser Ser Thr
     255                 260                 265

 gcg ggc tct cag gcc gag cag tca ggc atg agg acc tac tac ttc agt      866
 Ala Gly Ser Gln Ala Glu Gln Ser Gly Met Arg Thr Tyr Tyr Phe Ser
 270                 275                 280                 285

 gcc gac acc cag gag gac atg aac gct tgg gtc agg gcc atg aac cag      914
 Ala Asp Thr Gln Glu Asp Met Asn Ala Trp Val Arg Ala Met Asn Gln
                 290                 295                 300

 gct gca cag gtg ctg tct cga tcg tca ctg aag agg gat atg gag aag      962
 Ala Ala Gln Val Leu Ser Arg Ser Ser Leu Lys Arg Asp Met Glu Lys
             305                 310                 315

 gtg gag cgg cag gct gtc ccc cag gcc aac cac aca gag tcc tgt cac     1010
 Val Glu Arg Gln Ala Val Pro Gln Ala Asn His Thr Glu Ser Cys His
         320                 325                 330

 gaa tgt ggc cgg gtg gga ccc gga cat acg aga gat tgt cct cat cgt     1058
 Glu Cys Gly Arg Val Gly Pro Gly His Thr Arg Asp Cys Pro His Arg
     335                 340                 345

 ggc cat gat gac att gtc aac ttc gag agg cag gag cag gag gga gag     1106
 Gly His Asp Asp Ile Val Asn Phe Glu Arg Gln Glu Gln Glu Gly Glu
 350                 355                 360                 365

 cag tac cgt tcc cag agg gac cca ctg gag ggc aag cgg gac cgg agc     1154
 Gln Tyr Arg Ser Gln Arg Asp Pro Leu Glu Gly Lys Arg Asp Arg Ser
                 370                 375                 380

 aag gcc agg tct ccg tac tcg cca gcc gag gag gat gcc ttg ttt atg     1202
 Lys Ala Arg Ser Pro Tyr Ser Pro Ala Glu Glu Asp Ala Leu Phe Met
             385                 390                 395

 gat tta ccc act ggc cca aga ggc cag cag gca cag ccc caa cgg gca     1250
 Asp Leu Pro Thr Gly Pro Arg Gly Gln Gln Ala Gln Pro Gln Arg Ala
         400                 405                 410

 gag aag aat gga atg ctg cct gcc tca tat ggc cca gga gaa cag aat     1298
 Glu Lys Asn Gly Met Leu Pro Ala Ser Tyr Gly Pro Gly Glu Gln Asn
     415                 420                 425

 ggg act ggt ggg tac cag cgg gcc ttt cct ccc agg acc aac cct gaa     1346
 Gly Thr Gly Gly Tyr Gln Arg Ala Phe Pro Pro Arg Thr Asn Pro Glu
 430                 435                 440                 445

 aaa cac agc caa agg aag agc aat ctg gcc cag gtg gag cac tgg gca     1394
 Lys His Ser Gln Arg Lys Ser Asn Leu Ala Gln Val Glu His Trp Ala
                 450                 455                 460

 agg gcc cag aaa ggg gat agc agg agt ctt ccc ttg gac cag acg ctt     1442
 Arg Ala Gln Lys Gly Asp Ser Arg Ser Leu Pro Leu Asp Gln Thr Leu
             465                 470                 475

 cct cgc cag ggt cct ggc caa tcc ctg tcc ttc cca gaa aac tac cag     1490
 Pro Arg Gln Gly Pro Gly Gln Ser Leu Ser Phe Pro Glu Asn Tyr Gln
         480                 485                 490

 act ctt ccc aag agc acc cga cac ccc tcg ggg ggc tcc tcg cca cct     1538
 Thr Leu Pro Lys Ser Thr Arg His Pro Ser Gly Gly Ser Ser Pro Pro
     495                 500                 505

 ccc cga aac ctg cca agt gac tac aag tat gcg cag gac cga gcc agc     1586
 Pro Arg Asn Leu Pro Ser Asp Tyr Lys Tyr Ala Gln Asp Arg Ala Ser
 510                 515                 520                 525

 cac ctg aag atg tcg agt gaa gag cgc cgg gcg cac cgg gat ggc acc     1634
 His Leu Lys Met Ser Ser Glu Glu Arg Arg Ala His Arg Asp Gly Thr
                 530                 535                 540

 gtg tgg cag ctc tac gag tgg cag cag cgc cag cag ttc cgg cac ggc     1682
 Val Trp Gln Leu Tyr Glu Trp Gln Gln Arg Gln Gln Phe Arg His Gly
             545                 550                 555

 agc ccc aca gcg ccc atc tgc ctt ggc tcc cca gag ttc acc gac cag     1730
 Ser Pro Thr Ala Pro Ile Cys Leu Gly Ser Pro Glu Phe Thr Asp Gln
         560                 565                 570

 ggc cgg agc agg agc atg cta gag gtg ccc cgc tcc atc tct gtg cct     1778
 Gly Arg Ser Arg Ser Met Leu Glu Val Pro Arg Ser Ile Ser Val Pro
     575                 580                 585

 cca tct ccc tcg gac atc cct ccc cca gga ccc cca agg gtc ttc cca     1826
 Pro Ser Pro Ser Asp Ile Pro Pro Pro Gly Pro Pro Arg Val Phe Pro
 590                 595                 600                 605

 ccc cgg cgg cca cac aca cca gca gag cga gtc aca gtg aag cca ccg     1874
 Pro Arg Arg Pro His Thr Pro Ala Glu Arg Val Thr Val Lys Pro Pro
                 610                 615                 620

 gac cag agg agg agt gtg gac atc tcg ctg ggg gat tct cca agg agg     1922
 Asp Gln Arg Arg Ser Val Asp Ile Ser Leu Gly Asp Ser Pro Arg Arg
             625                 630                 635

 gca cgg ggc cac gct gtc aag aac tca tct cat gtg gac cga cgc tcc     1970
 Ala Arg Gly His Ala Val Lys Asn Ser Ser His Val Asp Arg Arg Ser
         640                 645                 650

 atg ccc tcc atg ggt tac atg acc cac acc gtc agc gct ccc agt tta     2018
 Met Pro Ser Met Gly Tyr Met Thr His Thr Val Ser Ala Pro Ser Leu
     655                 660                 665

 cat gga aaa tcg gct gat gat acc tac ctc cag ctg aag aaa gac ctg     2066
 His Gly Lys Ser Ala Asp Asp Thr Tyr Leu Gln Leu Lys Lys Asp Leu
 670                 675                 680                 685

 gag tac ctg gat cta aag atg aca ggc cgg gac ctt ctc aag gat cga     2114
 Glu Tyr Leu Asp Leu Lys Met Thr Gly Arg Asp Leu Leu Lys Asp Arg
                 690                 695                 700

 agt ctg aag cct gtg aag atc gct gag agc gac act gac gtc aaa ctg     2162
 Ser Leu Lys Pro Val Lys Ile Ala Glu Ser Asp Thr Asp Val Lys Leu
             705                 710                 715

 agc atc ttc tgt gaa caa gac agg gtc ctc cag gac ttg gaa gac aag     2210
 Ser Ile Phe Cys Glu Gln Asp Arg Val Leu Gln Asp Leu Glu Asp Lys
         720                 725                 730

 ata cga gcc ctt aaa gag aac aaa gac cag cta gaa tct gtg ctg gag     2258
 Ile Arg Ala Leu Lys Glu Asn Lys Asp Gln Leu Glu Ser Val Leu Glu
     735                 740                 745

 gtg ttg cac aga cag atg gag cag tac cga gac cag ccc cag cac ttg     2306
 Val Leu His Arg Gln Met Glu Gln Tyr Arg Asp Gln Pro Gln His Leu
 750                 755                 760                 765

 gag aag att gcc tac cag cag aag ttg ctg cag gag gac ctt gtc cat     2354
 Glu Lys Ile Ala Tyr Gln Gln Lys Leu Leu Gln Glu Asp Leu Val His
                 770                 775                 780

 atc cga gct gag ctc tcc aga gag tcc act gag atg gaa aat gct tgg     2402
 Ile Arg Ala Glu Leu Ser Arg Glu Ser Thr Glu Met Glu Asn Ala Trp
             785                 790                 795

 aac gaa tac ccg aag ttg gag aat gat gtg gaa cag ctg aag cag acc     2450
 Asn Glu Tyr Pro Lys Leu Glu Asn Asp Val Glu Gln Leu Lys Gln Thr
         800                 805                 810

 ctg cag gag caa cac aga aga gcc ttt ttt ttc cag gag aaa tcg cag     2498
 Leu Gln Glu Gln His Arg Arg Ala Phe Phe Phe Gln Glu Lys Ser Gln
     815                 820                 825

 ata cag aaa gat cta tgg aga att gaa gat gtc act gca ggc ctg agt     2546
 Ile Gln Lys Asp Leu Trp Arg Ile Glu Asp Val Thr Ala Gly Leu Ser
 830                 835                 840                 845

 gca aat aaa gag aac ttc aga att cta gtg gag tca gta aaa aat ccg     2594
 Ala Asn Lys Glu Asn Phe Arg Ile Leu Val Glu Ser Val Lys Asn Pro
                 850                 855                 860

 ggt gag atg ttc atc ttc ctg gat gtg ggg gat ctg att ggg ggc agg     2642
 Gly Glu Met Phe Ile Phe Leu Asp Val Gly Asp Leu Ile Gly Gly Arg
             865                 870                 875

 gtg gtg gga ggg tgg aag gct ggg aac cag gaa gat gaa gca cct ccc     2690
 Val Val Gly Gly Trp Lys Ala Gly Asn Gln Glu Asp Glu Ala Pro Pro
         880                 885                 890

 agg ccc cca ctc ccc gaa ctc tac agc cca gag gac cag ccc ccg gct     2738
 Arg Pro Pro Leu Pro Glu Leu Tyr Ser Pro Glu Asp Gln Pro Pro Ala
     895                 900                 905

 gtg ccg cct ctg cca aga gag gcc acc atc atc cgg cac aca tct gtg     2786
 Val Pro Pro Leu Pro Arg Glu Ala Thr Ile Ile Arg His Thr Ser Val
 910                 915                 920                 925

 cgg ggc ctc aag cgg cag tca gac gag agg aag cga gac cgg gag ctg     2834
 Arg Gly Leu Lys Arg Gln Ser Asp Glu Arg Lys Arg Asp Arg Glu Leu
                 930                 935                 940

 ggg cag tgt gtg aat ggg gat tcc agg gtg gag ctg cgg tcg tat gtc     2882
 Gly Gln Cys Val Asn Gly Asp Ser Arg Val Glu Leu Arg Ser Tyr Val
             945                 950                 955

 agt gag cct gag ctg gcg acc ctc agc ggg gac atg gcc cag ccc tcc     2930
 Ser Glu Pro Glu Leu Ala Thr Leu Ser Gly Asp Met Ala Gln Pro Ser
         960                 965                 970

 cta gga ctt gtg ggc cct gag agc agg tac cag acg ctg cca ggc aga     2978
 Leu Gly Leu Val Gly Pro Glu Ser Arg Tyr Gln Thr Leu Pro Gly Arg
     975                 980                 985

 ggg ctc tca ggg tcc acg tca agg ctc cag cag tcg tcc acc att gct     3026
 Gly Leu Ser Gly Ser Thr Ser Arg Leu Gln Gln Ser Ser Thr Ile Ala
 990                 995                1000                1005

 ccc tac gtc aca ctc cgg agg ggt ctc aat gcc gaa agc agc aag gcg     3074
 Pro Tyr Val Thr Leu Arg Arg Gly Leu Asn Ala Glu Ser Ser Lys Ala
                1010                1015                1020

 acc ttc cct aga cct aag agt gcc ttg gag cgc ctg tac tca ggg gat     3122
 Thr Phe Pro Arg Pro Lys Ser Ala Leu Glu Arg Leu Tyr Ser Gly Asp
            1025                1030                1035

 cac cag cga ggc aag atg agt gca gag gag cag ctg gag cgc atg aag     3170
 His Gln Arg Gly Lys Met Ser Ala Glu Glu Gln Leu Glu Arg Met Lys
        1040                1045                1050

 cga cac cag aag gcc ctg gtc cga gag cgc aag agg aca ctg ggc caa     3218
 Arg His Gln Lys Ala Leu Val Arg Glu Arg Lys Arg Thr Leu Gly Gln
    1055                1060                1065

 ggg gag agg acg ggc ctg ccc tca tct cgc tac ctc agc cgg ccg ctc     3266
 Gly Glu Arg Thr Gly Leu Pro Ser Ser Arg Tyr Leu Ser Arg Pro Leu
1070                1075                1080                1085

 cct gga gat ctt ggc tca tgg aag cgt gag cag gac ttt gac ctg cag     3314
 Pro Gly Asp Leu Gly Ser Trp Lys Arg Glu Gln Asp Phe Asp Leu Gln
                1090                1095                1100

 ttg ctg gaa cgg gtc gtg caa ggg gaa aaa aag gac aag gag gag aat     3362
 Leu Leu Glu Arg Val Val Gln Gly Glu Lys Lys Asp Lys Glu Glu Asn
            1105                1110                1115

 ggc tgg ttg aaa gtg cag gcc atg cct gtc act gag ttg gac ctg gag     3410
 Gly Trp Leu Lys Val Gln Ala Met Pro Val Thr Glu Leu Asp Leu Glu
        1120                1125                1130

 cct caa cac tat gac ttg gac atc agc aga gag ctg tcc aaa cca gag     3458
 Pro Gln His Tyr Asp Leu Asp Ile Ser Arg Glu Leu Ser Lys Pro Glu
    1135                1140                1145

 aag gtg tca atc cct gag cgc tac gtg gag cta gat ccc gaa gag cca     3506
 Lys Val Ser Ile Pro Glu Arg Tyr Val Glu Leu Asp Pro Glu Glu Pro
1150                1155                1160                1165

 ccc agc ctt gag gag ctg cag gcg cgg tac cgc aaa gcc gag aag atc     3554
 Pro Ser Leu Glu Glu Leu Gln Ala Arg Tyr Arg Lys Ala Glu Lys Ile
                1170                1175                1180

 cgc aac atc ctc gcc cgg tca agc atg tgc aac cta cag ccg acc tca     3602
 Arg Asn Ile Leu Ala Arg Ser Ser Met Cys Asn Leu Gln Pro Thr Ser
            1185                1190                1195

 ggc cag gac cag aac agt gtg gct gac ctg gac ttg cag ctg cag gag     3650
 Gly Gln Asp Gln Asn Ser Val Ala Asp Leu Asp Leu Gln Leu Gln Glu
        1200                1205                1210

 cag gag cgc atc atc aac atc tcc tac gcc ctg gcc tcc gag gcc tcc     3698
 Gln Glu Arg Ile Ile Asn Ile Ser Tyr Ala Leu Ala Ser Glu Ala Ser
    1215                1220                1225

 cag cgt agc aag cag gtg gca gcc cag gca gtg act gac ccg tga ccc     3746
 Gln Arg Ser Lys Gln Val Ala Ala Gln Ala Val Thr Asp Pro 
1230                1235                1240

 agcatgcaaa gaagcctgga gccaggggcc cagtggaacc agcttcctcc aaggagatga   3806

 cctttctgcc cccaaggaaa ccccttccag ctgagcaggg aatccggccg gaggaaggag   3866

 cagcttaccg actgcgggtg ttcaccacag gccaggccta atatgcaccc actagtttag   3926

 ctcagactcc tctctacata tgaatggcaa aggcactttt gatatacact gtaaaataca   3986

 ctgtatttta gaatcggaat ctattttcta atgttcccct caagggctga gttggcagga   4046

 aggttgagga tgcaggactt tgcagctgca cgtacagatt caggtacttc tgggtgacag   4106

 gtgttgtggg ggcaggaggg cggggcaagc cgaggctatc caattcaatg acctcaggag   4166

 aagtgcagaa ttgcagaggg ttccagtaag actcaagcag aggtggttgg gtgcgt       4222




      <210> 4
      <211> 776
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (17)..(736)

      <400> 4
 actggacgag gcgcgg    atg gtt ttc ctg gtt tcg gac ccc agc ggc cgg      49
                      Met Val Phe Leu Val Ser Asp Pro Ser Gly Arg
                        1               5                  10

 atg gtg aaa tcc tcc ctg cag cgg atc ctc aat agc cac tgc ttc gcc       97
 Met Val Lys Ser Ser Leu Gln Arg Ile Leu Asn Ser His Cys Phe Ala
              15                  20                  25

 aga gag aag gaa ggg gat aaa ccc agc gcc acc atc cac gcc agc cgc      145
 Arg Glu Lys Glu Gly Asp Lys Pro Ser Ala Thr Ile His Ala Ser Arg
          30                  35                  40

 acc atg ccg ctc cta agc ctg cac agc cgc ggc gca gca gca gtg aga      193
 Thr Met Pro Leu Leu Ser Leu His Ser Arg Gly Ala Ala Ala Val Arg
      45                  50                  55

 gtt cca ggg tct ccc tcc act gct gta gta acc cgg gtc cgg ggc ctc      241
 Val Pro Gly Ser Pro Ser Thr Ala Val Val Thr Arg Val Arg Gly Leu
  60                  65                  70                  75

 ggt ggt gct cct gat gcc cct cgc cca ccc ctg aag atc cca ggg ggg      289
 Gly Gly Ala Pro Asp Ala Pro Arg Pro Pro Leu Lys Ile Pro Gly Gly
                  80                  85                  90

 cga ggg aat agt cag agg gat cac aat ctt tca gct aac tta ttc tac      337
 Arg Gly Asn Ser Gln Arg Asp His Asn Leu Ser Ala Asn Leu Phe Tyr
              95                 100                 105

 tcc gat gat cgg ctg aat gta aca gag gaa cta acg tcc aac gac aag      385
 Ser Asp Asp Arg Leu Asn Val Thr Glu Glu Leu Thr Ser Asn Asp Lys
         110                 115                 120

 acg agg att ctc aac gtc cag tcc agg ctc aca gac gcc aaa cgc att      433
 Thr Arg Ile Leu Asn Val Gln Ser Arg Leu Thr Asp Ala Lys Arg Ile
     125                 130                 135

 aac tgg cga aca gtg ctg agt ggc ggc agc ctc tac atc gag atc ccg      481
 Asn Trp Arg Thr Val Leu Ser Gly Gly Ser Leu Tyr Ile Glu Ile Pro
 140                 145                 150                 155

 ggc ggc gcg ctg ccc gag ggg agc aag gac agc ttt gca gtt ctc ctg      529
 Gly Gly Ala Leu Pro Glu Gly Ser Lys Asp Ser Phe Ala Val Leu Leu
                 160                 165                 170

 gag ttc gct gag gag cag ctg cga gcc gac cat gtc ttc att tgc ttc      577
 Glu Phe Ala Glu Glu Gln Leu Arg Ala Asp His Val Phe Ile Cys Phe
             175                 180                 185

 cac aag aac cgc gag gac aga gcc gcc ttg ctc cga acc ttc agc ttt      625
 His Lys Asn Arg Glu Asp Arg Ala Ala Leu Leu Arg Thr Phe Ser Phe
         190                 195                 200

 ttg ggc ttt gag att gtg aga ccg ggg cat ccc ctt gtc ccc aaa aga      673
 Leu Gly Phe Glu Ile Val Arg Pro Gly His Pro Leu Val Pro Lys Arg
     205                 210                 215

 ccc gac gct tgc ttc atg gcc tac acg ttc gaa aaa gag tct tcg gga      721
 Pro Asp Ala Cys Phe Met Ala Tyr Thr Phe Glu Lys Glu Ser Ser Gly
 220                 225                 230                 235

 aag gag gag gag tag ggccgcctcg gggctgggca tccggcccct ggggccaccc      776
 Lys Glu Glu Glu 






      <210> 5
      <211> 1221
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (84)..(1178)

      <400> 5
 ccgcagaggc cggtgaggcg ccggcggcca cgccgcggaa ggcgcgggcc gagcagagcc     60

 gggcgttgga gccctgcgcg cgc    atg gag gcg gtt gcc ggc agc ccc ctg     110
                              Met Glu Ala Val Ala Gly Ser Pro Leu
                                1               5

 agg gca gcg ggg aga caa gac ccg gcg acc tcg cgc atc cct cga gcc      158
 Arg Ala Ala Gly Arg Gln Asp Pro Ala Thr Ser Arg Ile Pro Arg Ala
  10                  15                  20                  25

 gcc acg cgc tct cgc cac cgg gcg gcg acg ggc cgc gga gcc ggc gcg      206
 Ala Thr Arg Ser Arg His Arg Ala Ala Thr Gly Arg Gly Ala Gly Ala
                  30                  35                  40

 gcc atg gcg acg ggc ggc cag cag aag gag aac acg ctg ctt cac gct      254
 Ala Met Ala Thr Gly Gly Gln Gln Lys Glu Asn Thr Leu Leu His Ala
              45                  50                  55

 ctt cgc cgg cgg cgt gtg gag gca cag ctt ggt gct att ttc act tgt      302
 Leu Arg Arg Arg Arg Val Glu Ala Gln Leu Gly Ala Ile Phe Thr Cys
          60                  65                  70

 cca cta gaa gtc att aag aca cgg ttg cag tct tca aga tta gct ctc      350
 Pro Leu Glu Val Ile Lys Thr Arg Leu Gln Ser Ser Arg Leu Ala Leu
      75                  80                  85

 cgg aca gtc tac tat cct cag gtt cat ctg ggg acc att agt gga gct      398
 Arg Thr Val Tyr Tyr Pro Gln Val His Leu Gly Thr Ile Ser Gly Ala
  90                  95                 100                 105

 gga atg gtg aga cca aca tcc gtg aca cct gga ctc ttt cag gtt ctg      446
 Gly Met Val Arg Pro Thr Ser Val Thr Pro Gly Leu Phe Gln Val Leu
                 110                 115                 120

 aag tcg atc ttg gag aaa gag gga cca aag tca ctt ttt aga ggc ttg      494
 Lys Ser Ile Leu Glu Lys Glu Gly Pro Lys Ser Leu Phe Arg Gly Leu
             125                 130                 135

 ggt cca aat ttg gtt gga gtt gca cca tca agg gct gta tac ttt gca      542
 Gly Pro Asn Leu Val Gly Val Ala Pro Ser Arg Ala Val Tyr Phe Ala
         140                 145                 150

 tgt tac tcc aaa gcc aaa gag caa ttt aat ggc att ttc gtg cct aac      590
 Cys Tyr Ser Lys Ala Lys Glu Gln Phe Asn Gly Ile Phe Val Pro Asn
     155                 160                 165

 agc aat att gtg cat att ttc tca gct ggc tct gca gct ttt atc aca      638
 Ser Asn Ile Val His Ile Phe Ser Ala Gly Ser Ala Ala Phe Ile Thr
 170                 175                 180                 185

 aat tcc tta atg aat cct ata tgg atg gtt aaa acc cga atg cag cta      686
 Asn Ser Leu Met Asn Pro Ile Trp Met Val Lys Thr Arg Met Gln Leu
                 190                 195                 200

 gaa cag aaa gtg agg ggc tct aag cag atg aat aca ctc cag tgt gct      734
 Glu Gln Lys Val Arg Gly Ser Lys Gln Met Asn Thr Leu Gln Cys Ala
             205                 210                 215

 cgt tac gtt tac cag acc gaa ggc att cgt ggc ttc tat aga gga tta      782
 Arg Tyr Val Tyr Gln Thr Glu Gly Ile Arg Gly Phe Tyr Arg Gly Leu
         220                 225                 230

 act gcc tcg tat gct gga att tcc gaa act ata atc tgc ttt gct att      830
 Thr Ala Ser Tyr Ala Gly Ile Ser Glu Thr Ile Ile Cys Phe Ala Ile
     235                 240                 245

 tat gaa agt tta aag aag tat ctg aaa gaa gct cca tta gcc tct tct      878
 Tyr Glu Ser Leu Lys Lys Tyr Leu Lys Glu Ala Pro Leu Ala Ser Ser
 250                 255                 260                 265

 gca aat ggg act gag aaa aat tcc aca agt ttt ttt gga ctt atg gca      926
 Ala Asn Gly Thr Glu Lys Asn Ser Thr Ser Phe Phe Gly Leu Met Ala
                 270                 275                 280

 gct gct gct ctt tct aag ggc tgt gcc tcc tgc att gct tat cca cac      974
 Ala Ala Ala Leu Ser Lys Gly Cys Ala Ser Cys Ile Ala Tyr Pro His
             285                 290                 295

 gaa gtc ata agg acg agg ctc cgg gaa gag ggc acc aag tac aag tct     1022
 Glu Val Ile Arg Thr Arg Leu Arg Glu Glu Gly Thr Lys Tyr Lys Ser
         300                 305                 310

 ttt gtc cag acg gcg cgc ctg gtg ttc cgg gaa gaa ggc tac ctt gcc     1070
 Phe Val Gln Thr Ala Arg Leu Val Phe Arg Glu Glu Gly Tyr Leu Ala
     315                 320                 325

 ttt tat aga gga ctg ttt gcc cag ctt atc cgg cag atc cca aat act     1118
 Phe Tyr Arg Gly Leu Phe Ala Gln Leu Ile Arg Gln Ile Pro Asn Thr
 330                 335                 340                 345

 gcc att gtg ttg tct act tat gag tta att gtg tac ctg tta gaa gac     1166
 Ala Ile Val Leu Ser Thr Tyr Glu Leu Ile Val Tyr Leu Leu Glu Asp
                 350                 355                 360

 cgt act cag taa cag gccggaaaat tgtgctctag aagaataaaa ctgaaaaact     1221
 Arg Thr Gln 






      <210> 6
      <211> 2535
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (135)..(2204)

      <400> 6
 ccatccctga ggtagagccg gaatttacct ttgtacttca cacggtcagg gttgggggtg     60

 actacgtggg tctggagctg actgccgtcc tgacacgtcc tagagctgca agcaggtcct    120

 gccagagagc cacc  atg acc tct cag cct ctc agg cta gca gaa gag tat     170
                  Met Thr Ser Gln Pro Leu Arg Leu Ala Glu Glu Tyr
                    1               5                  10

 ggc cca agt cct ggg gag tct gaa ctg gct gtg aac ccc ttt gat ggg      218
 Gly Pro Ser Pro Gly Glu Ser Glu Leu Ala Val Asn Pro Phe Asp Gly
          15                  20                  25

 ctt ccc ttc tct tcc cgc tac tat gag ctg ctg aag cag cgc caa gcc      266
 Leu Pro Phe Ser Ser Arg Tyr Tyr Glu Leu Leu Lys Gln Arg Gln Ala
      30                  35                  40

 ttg ccc atc tgg gct gct cgc ttt acc ttc ttg gag cag ttg gag agt      314
 Leu Pro Ile Trp Ala Ala Arg Phe Thr Phe Leu Glu Gln Leu Glu Ser
  45                  50                  55                  60

 aac ccc act gga gtg gtg ctg gtg tct ggg gag cct ggt tct ggc aag      362
 Asn Pro Thr Gly Val Val Leu Val Ser Gly Glu Pro Gly Ser Gly Lys
                  65                  70                  75

 agc acc cag atc cct cag tgg tgt gca gag ttt gcg ctg gcc aga ggg      410
 Ser Thr Gln Ile Pro Gln Trp Cys Ala Glu Phe Ala Leu Ala Arg Gly
              80                  85                  90

 ttc cag aaa gga cag gtt act gtt act cag ccc tac cct ctt gca gcc      458
 Phe Gln Lys Gly Gln Val Thr Val Thr Gln Pro Tyr Pro Leu Ala Ala
          95                 100                 105

 cgg agc ctg gct ctg cgg gtt gct gat gag atg gac ctg acc ctg ggt      506
 Arg Ser Leu Ala Leu Arg Val Ala Asp Glu Met Asp Leu Thr Leu Gly
     110                 115                 120

 cat gag gtt gga tac agc atc ccc cag gag gac tgc acg ggg ccc aac      554
 His Glu Val Gly Tyr Ser Ile Pro Gln Glu Asp Cys Thr Gly Pro Asn
 125                 130                 135                 140

 acc ctg ctc agg ttc tgc tgg gac agg ctg ctt ctg cag gag gtg gcc      602
 Thr Leu Leu Arg Phe Cys Trp Asp Arg Leu Leu Leu Gln Glu Val Ala
                 145                 150                 155

 tcg acc cga ggc act gga gcc tgg ggc gtg ctg gta cta gat gag gct      650
 Ser Thr Arg Gly Thr Gly Ala Trp Gly Val Leu Val Leu Asp Glu Ala
             160                 165                 170

 cag gag cgg tcg gtg gca tca gat tca ctc cag ggg cta ctg caa gat      698
 Gln Glu Arg Ser Val Ala Ser Asp Ser Leu Gln Gly Leu Leu Gln Asp
         175                 180                 185

 gcc agg ctg gaa aaa ctt ccg ggg gac ctc aga gtg gtt gtg gtt act      746
 Ala Arg Leu Glu Lys Leu Pro Gly Asp Leu Arg Val Val Val Val Thr
     190                 195                 200

 gac cca gcc ctt gaa cct aag ctc cga gct ttc tgg ggc aat cct cct      794
 Asp Pro Ala Leu Glu Pro Lys Leu Arg Ala Phe Trp Gly Asn Pro Pro
 205                 210                 215                 220

 att gtg cat ata ccc aga gag cct ggt gag aga cct tcc ccc atc tac      842
 Ile Val His Ile Pro Arg Glu Pro Gly Glu Arg Pro Ser Pro Ile Tyr
                 225                 230                 235

 tgg gac acc atc cca cct gat cgg gtg gaa gct gcc tgc caa gca gtg      890
 Trp Asp Thr Ile Pro Pro Asp Arg Val Glu Ala Ala Cys Gln Ala Val
             240                 245                 250

 ctt gaa ttg tgt cgg aag gag ctt cca gga gat gtg cta gtg ttc ctg      938
 Leu Glu Leu Cys Arg Lys Glu Leu Pro Gly Asp Val Leu Val Phe Leu
         255                 260                 265

 ccc agt gag gag gaa att tcc ctg tgc tgt gaa tcc ttg tcc agg gag      986
 Pro Ser Glu Glu Glu Ile Ser Leu Cys Cys Glu Ser Leu Ser Arg Glu
     270                 275                 280

 gta gag tcc ttg ctt ctc caa ggg ctt cca cca cga gta ctg ccc ctt     1034
 Val Glu Ser Leu Leu Leu Gln Gly Leu Pro Pro Arg Val Leu Pro Leu
 285                 290                 295                 300

 cac cca gac tgt gga cga gcc gtt cag gct gtg tat gag gac atg gat     1082
 His Pro Asp Cys Gly Arg Ala Val Gln Ala Val Tyr Glu Asp Met Asp
                 305                 310                 315

 gcc cga aag gtt gtg gtc act cac tgg ctg gct gac ttc tcc ttc tcc     1130
 Ala Arg Lys Val Val Val Thr His Trp Leu Ala Asp Phe Ser Phe Ser
             320                 325                 330

 ctc cct tcc atc caa cat gtc atc gac tca gga ctg gag ctc cga agt     1178
 Leu Pro Ser Ile Gln His Val Ile Asp Ser Gly Leu Glu Leu Arg Ser
         335                 340                 345

 gtc ttt ttc ccc tca gga tcc tgc ctc tgc ctg tat cct aag tcc ttc     1226
 Val Phe Phe Pro Ser Gly Ser Cys Leu Cys Leu Tyr Pro Lys Ser Phe
     350                 355                 360

 tta gaa cta gaa gct cca cca ttg cca caa ccc agg gtg tgt gag gag     1274
 Leu Glu Leu Glu Ala Pro Pro Leu Pro Gln Pro Arg Val Cys Glu Glu
 365                 370                 375                 380

 aat ctg agc tcc ctg gtg tta cta cta aaa agg aga cag att gca gag     1322
 Asn Leu Ser Ser Leu Val Leu Leu Leu Lys Arg Arg Gln Ile Ala Glu
                 385                 390                 395

 cca ggg gag tgt cac ttc ctg gac cag cct gct cca gaa gca ctg atg     1370
 Pro Gly Glu Cys His Phe Leu Asp Gln Pro Ala Pro Glu Ala Leu Met
             400                 405                 410

 caa gcc ctg gaa gat tta gac tat ctg gca gcc ctg gat gat gat ggg     1418
 Gln Ala Leu Glu Asp Leu Asp Tyr Leu Ala Ala Leu Asp Asp Asp Gly
         415                 420                 425

 gac ctg tca gat ctg ggt gtc ata cta tca gaa ttc cct ctg gcc cct     1466
 Asp Leu Ser Asp Leu Gly Val Ile Leu Ser Glu Phe Pro Leu Ala Pro
     430                 435                 440

 gag ctg gcc aaa gcc ctg ctg gcc tca tgc gag ttt gac tgt gtg gac     1514
 Glu Leu Ala Lys Ala Leu Leu Ala Ser Cys Glu Phe Asp Cys Val Asp
 445                 450                 455                 460

 gag atg ctc acc ctg gct gcc atg ctc aca gct gcc cct ggg ttt acc     1562
 Glu Met Leu Thr Leu Ala Ala Met Leu Thr Ala Ala Pro Gly Phe Thr
                 465                 470                 475

 cgt cct cca ctc agt gca gaa gaa gct gcc ctg cgt cgg gcc ctg gaa     1610
 Arg Pro Pro Leu Ser Ala Glu Glu Ala Ala Leu Arg Arg Ala Leu Glu
             480                 485                 490

 cac acg gat ggt gac cac agt tct ctg atc cag gtg tat gaa gcc ttt     1658
 His Thr Asp Gly Asp His Ser Ser Leu Ile Gln Val Tyr Glu Ala Phe
         495                 500                 505

 ata caa agt gga gca gat gag gct tgg tgc cag gct cga ggt ctg aat     1706
 Ile Gln Ser Gly Ala Asp Glu Ala Trp Cys Gln Ala Arg Gly Leu Asn
     510                 515                 520

 tgg gca gca ttg tgc caa gcc cat aaa ctt cgg gga gaa ctc cta gaa     1754
 Trp Ala Ala Leu Cys Gln Ala His Lys Leu Arg Gly Glu Leu Leu Glu
 525                 530                 535                 540

 ctc atg caa cga att gaa ctt ccc ttg tcc cta cca gcc ttt ggc tct     1802
 Leu Met Gln Arg Ile Glu Leu Pro Leu Ser Leu Pro Ala Phe Gly Ser
                 545                 550                 555

 gag cag aat cgc aga gac ctt cag aaa gca ctg gtg tca gga tac ttt     1850
 Glu Gln Asn Arg Arg Asp Leu Gln Lys Ala Leu Val Ser Gly Tyr Phe
             560                 565                 570

 ctc aag gtg gcc aga gac aca gac ggg act gga aat tac cta ctc cta     1898
 Leu Lys Val Ala Arg Asp Thr Asp Gly Thr Gly Asn Tyr Leu Leu Leu
         575                 580                 585

 acc cat aag cat gtg gcc cag ctc tcc tca tac tgc tgc tac cga agc     1946
 Thr His Lys His Val Ala Gln Leu Ser Ser Tyr Cys Cys Tyr Arg Ser
     590                 595                 600

 cgc aga gct cct gcc aga ccc cca cca tgg gtg ctc tac cac aat ttc     1994
 Arg Arg Ala Pro Ala Arg Pro Pro Pro Trp Val Leu Tyr His Asn Phe
 605                 610                 615                 620

 acc ata tcc aaa gac aac tgc ctt tcc att gtt tct gag att caa cca     2042
 Thr Ile Ser Lys Asp Asn Cys Leu Ser Ile Val Ser Glu Ile Gln Pro
                 625                 630                 635

 cag atg ctg gtg gaa ttg gcc cct cca tac ttc ctg agt aac ttg cct     2090
 Gln Met Leu Val Glu Leu Ala Pro Pro Tyr Phe Leu Ser Asn Leu Pro
             640                 645                 650

 ccc agt gag agc aga gac ctt ctg aac cag cta agg gaa gga atg gca     2138
 Pro Ser Glu Ser Arg Asp Leu Leu Asn Gln Leu Arg Glu Gly Met Ala
         655                 660                 665

 gat tct aca gca ggg agc aaa tca tcc tca gcc cag gag ttc aga gat     2186
 Asp Ser Thr Ala Gly Ser Lys Ser Ser Ser Ala Gln Glu Phe Arg Asp
     670                 675                 680

 ccc tgt gtc ctg cag tga cctgcc tgcctatgga atggagctgg gttcatctca     2240
 Pro Cys Val Leu Gln 
 685

 tcacattaga ttatccctca gggtgacacc aaagcaccca gacagattta gaagcccaaa   2300

 gtttagggtc aaatgtaaac cctggaacct gagtcccaag aaatggtaga ctgggaatgg   2360

 aaagaatggg gtaaaccaca gtctacatag ggaaggactc tttccttagc cttctcttat   2420

 tgattggaga gggactgaca tgctcctcat tctcttaact ttgccaaacc cattcttgta   2480

 ctcccttgtg atctataaaa gatttttcta tgatgccaaa aaaaaaaaaa aaaag        2535




      <210> 7
      <211> 2005
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (66)..(806)

      <400> 7
 ctgtggtaca tgacaaagtc tggtgtggct ataggaacaa aatctatgtg gtgcagccaa     60

 aggcc    atg aaa ata gag aaa tct ttt gat gca cat ccc agg aag gag     107
          Met Lys Ile Glu Lys Ser Phe Asp Ala His Pro Arg Lys Glu
            1               5                  10

 agc caa gtg cga cag ctt gcg tgg gtg ggg gat ggc gtg tgg gtc tcc      155
 Ser Gln Val Arg Gln Leu Ala Trp Val Gly Asp Gly Val Trp Val Ser
  15                  20                  25                  30

 att cgc ttg gat tct acg ctc cgt ctc tat cat gca cac act tat caa      203
 Ile Arg Leu Asp Ser Thr Leu Arg Leu Tyr His Ala His Thr Tyr Gln
                  35                  40                  45

 cat cta cag gat gtg gac att gag cct tat gta agc aaa atg tta ggt      251
 His Leu Gln Asp Val Asp Ile Glu Pro Tyr Val Ser Lys Met Leu Gly
              50                  55                  60

 act gga aaa ctg ggc ttc tct ttt gtg aga att aca gct ctt atg gtg      299
 Thr Gly Lys Leu Gly Phe Ser Phe Val Arg Ile Thr Ala Leu Met Val
          65                  70                  75

 tct tgt aat cgt ttg tgg gtg ggg aca gga aat ggt gtc att atc tcc      347
 Ser Cys Asn Arg Leu Trp Val Gly Thr Gly Asn Gly Val Ile Ile Ser
      80                  85                  90

 atc cca ttg aca gaa aca aat aaa acc tca ggt gta cca gga aat cgt      395
 Ile Pro Leu Thr Glu Thr Asn Lys Thr Ser Gly Val Pro Gly Asn Arg
  95                 100                 105                 110

 cct gga agt gta atc cgt gta tat ggt gat gaa aac agt gat aaa gtg      443
 Pro Gly Ser Val Ile Arg Val Tyr Gly Asp Glu Asn Ser Asp Lys Val
                 115                 120                 125

 act cca ggg aca ttt ata ccc tat tgt tca atg gca cat gca cag ctt      491
 Thr Pro Gly Thr Phe Ile Pro Tyr Cys Ser Met Ala His Ala Gln Leu
             130                 135                 140

 tgc ttc cat ggg cac cgg gat gct gtg aaa ttc ttt gtg gca gtc cca      539
 Cys Phe His Gly His Arg Asp Ala Val Lys Phe Phe Val Ala Val Pro
         145                 150                 155

 ggt caa gtc atc agc cca caa agt agc agt agt ggc acg gat ctg acg      587
 Gly Gln Val Ile Ser Pro Gln Ser Ser Ser Ser Gly Thr Asp Leu Thr
     160                 165                 170

 ggt gac aaa gca ggg cca tct gca cag gag cct ggt agt cag acg ccc      635
 Gly Asp Lys Ala Gly Pro Ser Ala Gln Glu Pro Gly Ser Gln Thr Pro
 175                 180                 185                 190

 ttg aag tct atg ctt gtc atc agt gga gga gag ggc tac atc gac ttc      683
 Leu Lys Ser Met Leu Val Ile Ser Gly Gly Glu Gly Tyr Ile Asp Phe
                 195                 200                 205

 cga atg ggt gat gaa ggt gga gaa tca gaa ctt ctt gga gag gat ctt      731
 Arg Met Gly Asp Glu Gly Gly Glu Ser Glu Leu Leu Gly Glu Asp Leu
             210                 215                 220

 cca ctt gaa cct tct gtc acc aaa gca gaa agg agt cac ttg ata gtg      779
 Pro Leu Glu Pro Ser Val Thr Lys Ala Glu Arg Ser His Leu Ile Val
         225                 230                 235

 tgg caa gtg atg tat ggc aat gag tga gccca tgggaaacag gtggagatgg      831
 Trp Gln Val Met Tyr Gly Asn Glu 
     240                 245

 ggaagccgtc tcttctgcat ggtttatttt ccctctatcc ttttatttaa tgctcttttg    891

 tgagataagt ttcaccacat aatgtgtgag cattttttcc tgttaacttt atattacaaa    951

 atccgttcta ccataacaat acagaggaac tagctgtgtt aactgcacca ggtgttatag   1011

 gtaacttcag tatattatga acaaatcaaa gaatgtttac ttcctgcaaa ctggtgaatt   1071

 atagaaagca atccagatgt ggtttactct gccacagtct aatgtcattc acttcatttg   1131

 atggggtcac ttgttagctg tcactaataa tggaattaat gggaaacact tgataaatga   1191

 aactgtaccg ttaaatacaa tagctgagtt ttccccagtg tattgtaaaa ttgacacaca   1251

 ctaatacaag atggattatc aggatgtatc taaatgtccc gagagggtta aaagctaact   1311

 gtaaattact ttaactttca ctttcaaatc tgacaaatct tgtttatatg gtatataaaa   1371

 ctttgttttc atcagatttg ggggggtttt atattaaaga aattaagact acactattta   1431

 aataaacgtt tcctgtttct gacttattag agctctaaag tttatgaggc ctacttctct   1491

 gaatattctg atgggttttt tttgagacca gtctcatttt catactgaca tgtctgaaag   1551

 atttattatt tataaagctt aggacatact ctgggaagct tagaagatac ttcagcactg   1611

 ggaggatttt ttaaaggaaa tgtgttttgt atttcttgta ccagagaatg gtgatgttga   1671

 ttgagttttt tccatgtaaa aaatgtactt gtttgccaaa tgttcctaga ttgctcttaa   1731

 cctgttaata caagtaaaac tgtagtgggg atggagtctg gcctaagtac agaatgaggg   1791

 atttaattag aaaagttatt ttcttttgtt ctgtatcaaa ctgcagaaca gctatatact   1851

 tggtattttg tacgtgaata acgttttagc ttttgtgccc ttttgagctt gaagggttat   1911

 cctcaaaggg gaaaactatg aaggggaaga agacaaacct aagataccat aaagtaaagg   1971

 ttgacattac atattttcat tcacaatgcc catt                               2005




      <210> 8
      <211> 2058
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2058)

      <400> 8
  atg ggc gtg gcc aac ccc gag gtg gct gga ggc cgc gcc ccc ttc cca      48
  Met Gly Val Ala Asn Pro Glu Val Ala Gly Gly Arg Ala Pro Phe Pro
    1               5                  10                  15

 gag tgc acc gca gcc gct gca ttc agg aac cgc ttt agc ttc ggc ccc       96
 Glu Cys Thr Ala Ala Ala Ala Phe Arg Asn Arg Phe Ser Phe Gly Pro
              20                  25                  30

 ggc cgg ccg ggc ggg gaa gac tgg tgt ggt ctg gcc atg gat ggg ctc      144
 Gly Arg Pro Gly Gly Glu Asp Trp Cys Gly Leu Ala Met Asp Gly Leu
          35                  40                  45

 cag gcc agt gca ggg ccg ttg agg cgc ggg cgg ccg agg cgc cgg cgc      192
 Gln Ala Ser Ala Gly Pro Leu Arg Arg Gly Arg Pro Arg Arg Arg Arg
      50                  55                  60

 aag ccc cag cca cac agc ggg tcg gtc ctg gcc ctg ccc ttg agg tcc      240
 Lys Pro Gln Pro His Ser Gly Ser Val Leu Ala Leu Pro Leu Arg Ser
  65                  70                  75                  80

 agg aag ata cga aag cag ctg cga agt gtt gta tcc cgc atg gca gcg      288
 Arg Lys Ile Arg Lys Gln Leu Arg Ser Val Val Ser Arg Met Ala Ala
                  85                  90                  95

 ctg agg acg cag acg ctg cct agc gag aac tcg gag gaa tcg agg gtg      336
 Leu Arg Thr Gln Thr Leu Pro Ser Glu Asn Ser Glu Glu Ser Arg Val
             100                 105                 110

 gag tcg acg gcc gac gac ctg ggg gac gcg cta ccc ggt ggg gcg gcg      384
 Glu Ser Thr Ala Asp Asp Leu Gly Asp Ala Leu Pro Gly Gly Ala Ala
         115                 120                 125

 gtg gcg gcc gtc ccg gac gca gcc cgg cga gag cca tac ggc cac ctg      432
 Val Ala Ala Val Pro Asp Ala Ala Arg Arg Glu Pro Tyr Gly His Leu
     130                 135                 140

 ggg ccc gca gag ctg ctg gag gcc tcg ccc gcc gcg cgc tcc ctg cag      480
 Gly Pro Ala Glu Leu Leu Glu Ala Ser Pro Ala Ala Arg Ser Leu Gln
 145                 150                 155                 160

 acc ccg tcg gcg cgc ctg gtg ccc gct tcc gcg ccg ccc gcg cgc ctg      528
 Thr Pro Ser Ala Arg Leu Val Pro Ala Ser Ala Pro Pro Ala Arg Leu
                 165                 170                 175

 gtg gag gtg ccc gcc gcg ccg gtc cgg gtg gtg gag acc tcg gcc ctg      576
 Val Glu Val Pro Ala Ala Pro Val Arg Val Val Glu Thr Ser Ala Leu
             180                 185                 190

 ctg tgc acc gcg caa cac tta gcg gcc gtc cag tcg tcc ggg gcc cct      624
 Leu Cys Thr Ala Gln His Leu Ala Ala Val Gln Ser Ser Gly Ala Pro
         195                 200                 205

 gcg acg gcg tcg ggg ccg cag gtg gat aac acg ggt ggg gag ccg gcc      672
 Ala Thr Ala Ser Gly Pro Gln Val Asp Asn Thr Gly Gly Glu Pro Ala
     210                 215                 220

 tgg gac tcc ccg ctg cgg cgc gtc ttg gcc gag ctg aac cgc atc ccc      720
 Trp Asp Ser Pro Leu Arg Arg Val Leu Ala Glu Leu Asn Arg Ile Pro
 225                 230                 235                 240

 agc agc cgg cgg cga gcg gcc cgc ctc ttt gag tgg ctc atc gcg ccc      768
 Ser Ser Arg Arg Arg Ala Ala Arg Leu Phe Glu Trp Leu Ile Ala Pro
                 245                 250                 255

 atg ccg cca gat cac ttc tac cgg cgc cta tgg gag cgc gag gcg gtg      816
 Met Pro Pro Asp His Phe Tyr Arg Arg Leu Trp Glu Arg Glu Ala Val
             260                 265                 270

 ctg gtg cgg cgg cag gac cac acc tac tac cag gga ctt ttc tct acc      864
 Leu Val Arg Arg Gln Asp His Thr Tyr Tyr Gln Gly Leu Phe Ser Thr
         275                 280                 285

 gct gac ctg gat tcg atg ctg cgc aac gag gag gtg cag ttc ggc cag      912
 Ala Asp Leu Asp Ser Met Leu Arg Asn Glu Glu Val Gln Phe Gly Gln
     290                 295                 300

 cat ttg gac gcc gct cgc tac atc aac gga cga cgc gag acc ctg aac      960
 His Leu Asp Ala Ala Arg Tyr Ile Asn Gly Arg Arg Glu Thr Leu Asn
 305                 310                 315                 320

 cca ccc ggc cgc gcg ctg ccc gcc gcc gcg tgg tcc ctg tac cag gcc     1008
 Pro Pro Gly Arg Ala Leu Pro Ala Ala Ala Trp Ser Leu Tyr Gln Ala
                 325                 330                 335

 ggc tgc tcc ctg cgt ctc ctc tgt ccg cag gct ttc tct act act gtg     1056
 Gly Cys Ser Leu Arg Leu Leu Cys Pro Gln Ala Phe Ser Thr Thr Val
             340                 345                 350

 tgg cag ttt ttg gct gtg ctt caa gag cag ttt gga agc atg gca ggc     1104
 Trp Gln Phe Leu Ala Val Leu Gln Glu Gln Phe Gly Ser Met Ala Gly
         355                 360                 365

 tcc aac gtt tac ctc acg ccc cct aac tcg cag ggc ttt gcc ccc cac     1152
 Ser Asn Val Tyr Leu Thr Pro Pro Asn Ser Gln Gly Phe Ala Pro His
     370                 375                 380

 tac gac gac atc gag gcc ttc gtg ctg cag ctg gaa ggt agg aaa ctc     1200
 Tyr Asp Asp Ile Glu Ala Phe Val Leu Gln Leu Glu Gly Arg Lys Leu
 385                 390                 395                 400

 tgg cgt gta tac cga ccc cga gcc cca acc gag gaa ctg gct ctg aca     1248
 Trp Arg Val Tyr Arg Pro Arg Ala Pro Thr Glu Glu Leu Ala Leu Thr
                 405                 410                 415

 tcc agc ccc aac ttc agt cag gac gac ctc ggt gag ccg gtg ctg cag     1296
 Ser Ser Pro Asn Phe Ser Gln Asp Asp Leu Gly Glu Pro Val Leu Gln
             420                 425                 430

 acc gtg ctg gaa cct gga gat ttg ctg tat ttt cct cgg ggc ttc att     1344
 Thr Val Leu Glu Pro Gly Asp Leu Leu Tyr Phe Pro Arg Gly Phe Ile
         435                 440                 445

 cac caa gct gaa tgc cag gat gga gtc cac tct ctg cac ctc acc ttg     1392
 His Gln Ala Glu Cys Gln Asp Gly Val His Ser Leu His Leu Thr Leu
     450                 455                 460

 tcc acg tac cag cgc aat acc tgg ggt gac ttc tta gag gcc ata ctg     1440
 Ser Thr Tyr Gln Arg Asn Thr Trp Gly Asp Phe Leu Glu Ala Ile Leu
 465                 470                 475                 480

 cct ctg gca gtg cag gct gca atg gaa gaa aat gtg gag ttt cgg agg     1488
 Pro Leu Ala Val Gln Ala Ala Met Glu Glu Asn Val Glu Phe Arg Arg
                 485                 490                 495

 ggt ctg ccc cga gac ttc atg gat tac atg ggg gcc cag cat tca gat     1536
 Gly Leu Pro Arg Asp Phe Met Asp Tyr Met Gly Ala Gln His Ser Asp
             500                 505                 510

 tct aag gat ccg cga aga acc gct ttc atg gag aag gtg cgg gtc ttg     1584
 Ser Lys Asp Pro Arg Arg Thr Ala Phe Met Glu Lys Val Arg Val Leu
         515                 520                 525

 gtt gcc cgc ctg gga cac ttt gct cct gtt gat gct gtg gcc gac cag     1632
 Val Ala Arg Leu Gly His Phe Ala Pro Val Asp Ala Val Ala Asp Gln
     530                 535                 540

 cga gcc aaa gac ttc att cac gat tct ctg ccc cct gtt ttg act gat     1680
 Arg Ala Lys Asp Phe Ile His Asp Ser Leu Pro Pro Val Leu Thr Asp
 545                 550                 555                 560

 agg gag agg gca cta agt gtt tac ggg ctt cca att cgc tgg gag gct     1728
 Arg Glu Arg Ala Leu Ser Val Tyr Gly Leu Pro Ile Arg Trp Glu Ala
                 565                 570                 575

 gga gaa cct gta aac gtg ggg gcc cag ttg aca aca gaa aca gaa gtc     1776
 Gly Glu Pro Val Asn Val Gly Ala Gln Leu Thr Thr Glu Thr Glu Val
             580                 585                 590

 cat atg ctt cag gat ggg ata gct cgg ctg gtg ggt gag ggg ggc cat     1824
 His Met Leu Gln Asp Gly Ile Ala Arg Leu Val Gly Glu Gly Gly His
         595                 600                 605

 ttg ttt ctc tat tac aca gtg gaa aac tcc cgt gtg tat cat ctg gaa     1872
 Leu Phe Leu Tyr Tyr Thr Val Glu Asn Ser Arg Val Tyr His Leu Glu
     610                 615                 620

 gaa ccc aag tgc ttg gaa ata tac ccc cag caa gct gat gcc atg gaa     1920
 Glu Pro Lys Cys Leu Glu Ile Tyr Pro Gln Gln Ala Asp Ala Met Glu
 625                 630                 635                 640

 ctg ttg ctt ggt tct tat cca gag ttt gtg aga gtg ggg gac ctg ccc     1968
 Leu Leu Leu Gly Ser Tyr Pro Glu Phe Val Arg Val Gly Asp Leu Pro
                 645                 650                 655

 tgt gac agt gtg gag gac cag ctg tcc ttg gca acc acg ttg tat gat     2016
 Cys Asp Ser Val Glu Asp Gln Leu Ser Leu Ala Thr Thr Leu Tyr Asp
             660                 665                 670

 aag ggg ctg ctg ctc act aag atg cct cta gcc cta aat tag             2058
 Lys Gly Leu Leu Leu Thr Lys Met Pro Leu Ala Leu Asn 
         675                 680                 685





      <210> 9
      <211> 3993
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (460)..(3993)

      <220>
      <221> misc_feature
      <222> (1)...(3993)
      <223> n = a,t,c or g

      <400> 9
 aacctggcac tattcttata attctttaaa aaattctcat aaaagtcttg atctatatgt     60

 gttttctgat ttgtgccaca aatactgcag tgttttcata ctaaaactat atctagatat    120

 aaactagata tattttcttc agattgtaat aaattggaac cccactttcc cttataattg    180

 atcacccnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn aannnnnnnn    240

 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnngacgt tttgattgaa    300

 aatggatgcg acattacaat tgaaaaagga tacatcactg tcttatggac agtcattctt    360

 ttttgtcata tctcgtggac cctacctaca tcaggatact tgccagttag agacatagat    420

 gaaacccgtc tggtgctacc agcctcaaaa ggtaagaat   atg aaa act caa cca     474
                                              Met Lys Thr Gln Pro
                                                1               5

 ccc ttg agc agg atg aac cgg gag gaa ttg gag gac agt ttc ttt cga      522
 Pro Leu Ser Arg Met Asn Arg Glu Glu Leu Glu Asp Ser Phe Phe Arg
                  10                  15                  20

 ctt cgc gaa gat cac atg ttg gtg aag gag ctt tct tgg aag caa cag      570
 Leu Arg Glu Asp His Met Leu Val Lys Glu Leu Ser Trp Lys Gln Gln
              25                  30                  35

 gat gag atc aaa agc ata att tct ttc agc agt gtc ata agt atg gct      618
 Asp Glu Ile Lys Ser Ile Ile Ser Phe Ser Ser Val Ile Ser Met Ala
          40                  45                  50

 aaa ccc att ggt cta tgc atg cct aac agt gcc cac atc atg gcc agc      666
 Lys Pro Ile Gly Leu Cys Met Pro Asn Ser Ala His Ile Met Ala Ser
      55                  60                  65

 aat acc atg caa gtg gaa gag cca ccc aag tct cct gag aaa atg tgg      714
 Asn Thr Met Gln Val Glu Glu Pro Pro Lys Ser Pro Glu Lys Met Trp
  70                  75                  80                  85

 cct aaa gat gaa aat ttt gaa cag aga agc tca ttg gag tgt gct cag      762
 Pro Lys Asp Glu Asn Phe Glu Gln Arg Ser Ser Leu Glu Cys Ala Gln
                  90                  95                 100

 aag gct gca gag ctt cga gct tcc att aaa gag aag gta gag ctg att      810
 Lys Ala Ala Glu Leu Arg Ala Ser Ile Lys Glu Lys Val Glu Leu Ile
             105                 110                 115

 cga ctt aag aag ctc tta cat gaa aga aat gct tca ttg gtt atg aca      858
 Arg Leu Lys Lys Leu Leu His Glu Arg Asn Ala Ser Leu Val Met Thr
         120                 125                 130

 aaa gca caa tta aca gaa gtt caa gag ata ttt aca gtc atg atc ttt      906
 Lys Ala Gln Leu Thr Glu Val Gln Glu Ile Phe Thr Val Met Ile Phe
     135                 140                 145

 ttt aag cct gac aac agc cct caa gag aat gct agg gtt gct ggt gtc      954
 Phe Lys Pro Asp Asn Ser Pro Gln Glu Asn Ala Arg Val Ala Gly Val
 150                 155                 160                 165

 tgg aga cca ctc gtg ctg agt gat atg acc att ccc aga ggt act ttc     1002
 Trp Arg Pro Leu Val Leu Ser Asp Met Thr Ile Pro Arg Gly Thr Phe
                 170                 175                 180

 ctt ttg acc cag aat cag gga atc ctg agt gca gcc cat gag gcc ctc     1050
 Leu Leu Thr Gln Asn Gln Gly Ile Leu Ser Ala Ala His Glu Ala Leu
             185                 190                 195

 ctc aag caa gtg aat gag ctc agg gca gag ctg aag gaa gaa agc aag     1098
 Leu Lys Gln Val Asn Glu Leu Arg Ala Glu Leu Lys Glu Glu Ser Lys
         200                 205                 210

 aag gct gtg agc ttg aag agc caa ctg gaa gat gtg tct atc ttg cag     1146
 Lys Ala Val Ser Leu Lys Ser Gln Leu Glu Asp Val Ser Ile Leu Gln
     215                 220                 225

 atg act ctg aag gag gag aga gtt gaa gat ttg gaa aaa gaa cga aaa     1194
 Met Thr Leu Lys Glu Glu Arg Val Glu Asp Leu Glu Lys Glu Arg Lys
 230                 235                 240                 245

 ttg ctg aat gac aat tat gac aaa ctc tta gaa agc atg ctg gac agc     1242
 Leu Leu Asn Asp Asn Tyr Asp Lys Leu Leu Glu Ser Met Leu Asp Ser
                 250                 255                 260

 agt gac agc tcc agt cag ccc cac tgg agc aac gag ctc ata gcg gaa     1290
 Ser Asp Ser Ser Ser Gln Pro His Trp Ser Asn Glu Leu Ile Ala Glu
             265                 270                 275

 cag cta cag cag caa gtc tct cag ctg cag gat cag ctg gat gct gag     1338
 Gln Leu Gln Gln Gln Val Ser Gln Leu Gln Asp Gln Leu Asp Ala Glu
         280                 285                 290

 ctg gag gac aag aga aaa gtt tta ctt gag ctg tcc agg gag aaa gcc     1386
 Leu Glu Asp Lys Arg Lys Val Leu Leu Glu Leu Ser Arg Glu Lys Ala
     295                 300                 305

 caa aat gag gat ctg aag ctt gaa gtc acc aac ata ctt cag aag cat     1434
 Gln Asn Glu Asp Leu Lys Leu Glu Val Thr Asn Ile Leu Gln Lys His
 310                 315                 320                 325

 aaa cag gaa gta gag ctc ctc caa aat gca gcc aca att tcc caa cct     1482
 Lys Gln Glu Val Glu Leu Leu Gln Asn Ala Ala Thr Ile Ser Gln Pro
                 330                 335                 340

 cct gac agg caa tct gaa cca gcc act cac cca gct gta ttg caa gag     1530
 Pro Asp Arg Gln Ser Glu Pro Ala Thr His Pro Ala Val Leu Gln Glu
             345                 350                 355

 aac act cag atc gag cca agt gaa ccc aaa aac caa gaa gaa aag aaa     1578
 Asn Thr Gln Ile Glu Pro Ser Glu Pro Lys Asn Gln Glu Glu Lys Lys
         360                 365                 370

 ctg tcc cag gtg cta aat gag ttg caa gta tca cac gca gag acc aca     1626
 Leu Ser Gln Val Leu Asn Glu Leu Gln Val Ser His Ala Glu Thr Thr
     375                 380                 385

 ttg gaa cta gaa aag acc agg gac atg ctt att ctg cag cgc aaa atc     1674
 Leu Glu Leu Glu Lys Thr Arg Asp Met Leu Ile Leu Gln Arg Lys Ile
 390                 395                 400                 405

 aac gtg tgt tat cag gtg caa gga aag atg gag gaa ctg gag gca atg     1722
 Asn Val Cys Tyr Gln Val Gln Gly Lys Met Glu Glu Leu Glu Ala Met
                 410                 415                 420

 atg aca aaa gct gac aat gat aat aga gat cac aaa gaa aag ctg gag     1770
 Met Thr Lys Ala Asp Asn Asp Asn Arg Asp His Lys Glu Lys Leu Glu
             425                 430                 435

 agg ttg act cga cta cta gac ctc aag aat aac cgt atc aag cag ctg     1818
 Arg Leu Thr Arg Leu Leu Asp Leu Lys Asn Asn Arg Ile Lys Gln Leu
         440                 445                 450

 gaa gaa cag ctc aaa gat gtt gct tat ggc acc cga ccg ttg tcg tta     1866
 Glu Glu Gln Leu Lys Asp Val Ala Tyr Gly Thr Arg Pro Leu Ser Leu
     455                 460                 465

 tgt ttg gaa aca ctg cca gcc cat gga gat gag gat aaa gtg gat att     1914
 Cys Leu Glu Thr Leu Pro Ala His Gly Asp Glu Asp Lys Val Asp Ile
 470                 475                 480                 485

 tct ctg ctg cat cag ggt gag aat ctt ttt gaa ctg cac atc cac cag     1962
 Ser Leu Leu His Gln Gly Glu Asn Leu Phe Glu Leu His Ile His Gln
                 490                 495                 500

 gcc ttc ctg aca tct gcc gcc cta gct cag gct gga gat acc caa cct     2010
 Ala Phe Leu Thr Ser Ala Ala Leu Ala Gln Ala Gly Asp Thr Gln Pro
             505                 510                 515

 acc act ttc tgc acc tat tcc ttc tat gac ttt gaa acc cac tgt acc     2058
 Thr Thr Phe Cys Thr Tyr Ser Phe Tyr Asp Phe Glu Thr His Cys Thr
         520                 525                 530

 cca tta tct gtg ggg cca cag ccc ctc tat gac ttc acc tcc cag tat     2106
 Pro Leu Ser Val Gly Pro Gln Pro Leu Tyr Asp Phe Thr Ser Gln Tyr
     535                 540                 545

 gtg atg gag aca gat tcg ctt ttc tta cac tac ctt caa gag gct tca     2154
 Val Met Glu Thr Asp Ser Leu Phe Leu His Tyr Leu Gln Glu Ala Ser
 550                 555                 560                 565

 gcc cgg ctt gac ata cac cag gcc atg gcc agt gaa cac agc act ctt     2202
 Ala Arg Leu Asp Ile His Gln Ala Met Ala Ser Glu His Ser Thr Leu
                 570                 575                 580

 gct gca gga tgg att tgc ttt gac agg gtg cta gag act gtg gag aaa     2250
 Ala Ala Gly Trp Ile Cys Phe Asp Arg Val Leu Glu Thr Val Glu Lys
             585                 590                 595

 gtc cat ggc ttg gcc aca ctg att gga gct ggt gga gaa gag ttc ggg     2298
 Val His Gly Leu Ala Thr Leu Ile Gly Ala Gly Gly Glu Glu Phe Gly
         600                 605                 610

 gtt cta gag tac tgg atg agg ctg cgt ttc ccc ata aaa ccc agc cta     2346
 Val Leu Glu Tyr Trp Met Arg Leu Arg Phe Pro Ile Lys Pro Ser Leu
     615                 620                 625

 cag gcg tgc aat aaa cga aag aaa gcc cag gtc tac ctg tca acc gat     2394
 Gln Ala Cys Asn Lys Arg Lys Lys Ala Gln Val Tyr Leu Ser Thr Asp
 630                 635                 640                 645

 gtg ctt gga ggc cgg aag gcc cag gaa gag gag ttc aga tcg gag tct     2442
 Val Leu Gly Gly Arg Lys Ala Gln Glu Glu Glu Phe Arg Ser Glu Ser
                 650                 655                 660

 tgg gaa cct cag aac gag ctg tgg att gaa atc acc aag tgc tgt ggc     2490
 Trp Glu Pro Gln Asn Glu Leu Trp Ile Glu Ile Thr Lys Cys Cys Gly
             665                 670                 675

 ctc cgg agt cga tgg ctg gga act caa ccc agt cca tat gct gtg tac     2538
 Leu Arg Ser Arg Trp Leu Gly Thr Gln Pro Ser Pro Tyr Ala Val Tyr
         680                 685                 690

 cgc ttc ttc acc ttt tct gac cat gac act gcc atc att cca gcc agt     2586
 Arg Phe Phe Thr Phe Ser Asp His Asp Thr Ala Ile Ile Pro Ala Ser
     695                 700                 705

 aac aac ccc tac ttt aga gac cag gct cga ttc cca gtg ctt gtg acc     2634
 Asn Asn Pro Tyr Phe Arg Asp Gln Ala Arg Phe Pro Val Leu Val Thr
 710                 715                 720                 725

 tct gac ctg gac cat tat ctg aga cgg gag gcc ttg tct ata cat gtt     2682
 Ser Asp Leu Asp His Tyr Leu Arg Arg Glu Ala Leu Ser Ile His Val
                 730                 735                 740

 ttt gat gat gaa gac tta gag cct ggc tcg tat ctt ggc cga gcc cga     2730
 Phe Asp Asp Glu Asp Leu Glu Pro Gly Ser Tyr Leu Gly Arg Ala Arg
             745                 750                 755

 gtg cct tta ctg cct ctt gca aaa aat gaa tct atc aaa ggt gat ttt     2778
 Val Pro Leu Leu Pro Leu Ala Lys Asn Glu Ser Ile Lys Gly Asp Phe
         760                 765                 770

 aac ctc act gac cct gca gag aaa ccc aac gga tct att caa gtg caa     2826
 Asn Leu Thr Asp Pro Ala Glu Lys Pro Asn Gly Ser Ile Gln Val Gln
     775                 780                 785

 ctg gat tgg aag ttt ccc tac ata ccc cct gag agc ttc ctg aaa cca     2874
 Leu Asp Trp Lys Phe Pro Tyr Ile Pro Pro Glu Ser Phe Leu Lys Pro
 790                 795                 800                 805

 gaa gct cag act aag ggg aag gat acc aag gac agt tca aag atc tca     2922
 Glu Ala Gln Thr Lys Gly Lys Asp Thr Lys Asp Ser Ser Lys Ile Ser
                 810                 815                 820

 tct gaa gag gaa aag gct tca ttt cct tcc cag gtt gtt aaa cta cca     2970
 Ser Glu Glu Glu Lys Ala Ser Phe Pro Ser Gln Val Val Lys Leu Pro
             825                 830                 835

 gct tgt aat gct atc tct gat ctt tct att cag gat cag atg gca tct     3018
 Ala Cys Asn Ala Ile Ser Asp Leu Ser Ile Gln Asp Gln Met Ala Ser
         840                 845                 850

 cct gag gtt ccc att gaa gct ggc cag tat cga tct aag aga aaa cct     3066
 Pro Glu Val Pro Ile Glu Ala Gly Gln Tyr Arg Ser Lys Arg Lys Pro
     855                 860                 865

 cct cat ggg gga gaa aga aag gag aag gag cac cag gtt gtg agc tac     3114
 Pro His Gly Gly Glu Arg Lys Glu Lys Glu His Gln Val Val Ser Tyr
 870                 875                 880                 885

 tca aga aga aaa cat ggc aaa aga ata ggt gtt caa gga aag aat aga     3162
 Ser Arg Arg Lys His Gly Lys Arg Ile Gly Val Gln Gly Lys Asn Arg
                 890                 895                 900

 atg gag tat ctt agc ctt aac atc tta aat gga aat aca cca gag gtg     3210
 Met Glu Tyr Leu Ser Leu Asn Ile Leu Asn Gly Asn Thr Pro Glu Val
             905                 910                 915

 aat tac act gag tgg aag ttc tca gag act aac agc ttc ata ggt gat     3258
 Asn Tyr Thr Glu Trp Lys Phe Ser Glu Thr Asn Ser Phe Ile Gly Asp
         920                 925                 930

 ggc ttt aaa aat cag cac gag gaa gag gaa atg aca tta tcc cat tca     3306
 Gly Phe Lys Asn Gln His Glu Glu Glu Glu Met Thr Leu Ser His Ser
     935                 940                 945

 gca ctg aaa cag aag gaa cct cta cat cct gta aat gac aaa gaa tcc     3354
 Ala Leu Lys Gln Lys Glu Pro Leu His Pro Val Asn Asp Lys Glu Ser
 950                 955                 960                 965

 tct gaa caa ggt tct gaa gtc agt gaa gca caa act acc gac agt gat     3402
 Ser Glu Gln Gly Ser Glu Val Ser Glu Ala Gln Thr Thr Asp Ser Asp
                 970                 975                 980

 gat gtc ata gtg cca ccc atg tct cag aaa tat cct aag gca gaa cta     3450
 Asp Val Ile Val Pro Pro Met Ser Gln Lys Tyr Pro Lys Ala Glu Leu
             985                 990                 995

 aat aaa cat ttt cct tat cag gat tca gag aag atg tgc att gaa att     3498
 Asn Lys His Phe Pro Tyr Gln Asp Ser Glu Lys Met Cys Ile Glu Ile
        1000                1005                1010

 gtc tcc ctg gcc ttc tac cca gag gca gaa gtg atg tct gat gag aac     3546
 Val Ser Leu Ala Phe Tyr Pro Glu Ala Glu Val Met Ser Asp Glu Asn
    1015                1020                1025

 ata aaa cag gtg tat gtg gag tac aaa ttc tac gac cta ccc ttg tcg     3594
 Ile Lys Gln Val Tyr Val Glu Tyr Lys Phe Tyr Asp Leu Pro Leu Ser
1030                1035                1040                1045

 gag aca gag act cca gtg tcc cta agg aag cct agg gca gga gaa gaa     3642
 Glu Thr Glu Thr Pro Val Ser Leu Arg Lys Pro Arg Ala Gly Glu Glu
                1050                1055                1060

 atc cac ttt cac ttt agc aag gta ata gac ctg gac cca cag gag cag     3690
 Ile His Phe His Phe Ser Lys Val Ile Asp Leu Asp Pro Gln Glu Gln
            1065                1070                1075

 caa ggc cga agg cgg ttt ctg ttc gac atg ctg aat gga caa gat cct     3738
 Gln Gly Arg Arg Arg Phe Leu Phe Asp Met Leu Asn Gly Gln Asp Pro
        1080                1085                1090

 gat caa gga cat tta aag ttt aca gtg gta agt gat cct ctg gat gaa     3786
 Asp Gln Gly His Leu Lys Phe Thr Val Val Ser Asp Pro Leu Asp Glu
    1095                1100                1105

 gaa aag aaa gaa tgt gaa gaa gtg gga tat gca tat ctt caa ctg tgg     3834
 Glu Lys Lys Glu Cys Glu Glu Val Gly Tyr Ala Tyr Leu Gln Leu Trp
1110                1115                1120                1125

 cag atc ctg gag tca gga aga gat att cta gag caa gag cta gac att     3882
 Gln Ile Leu Glu Ser Gly Arg Asp Ile Leu Glu Gln Glu Leu Asp Ile
                1130                1135                1140

 gtt agc cct gaa gat ctg gct acc cca ata gga agg ctg aag gtt tcc     3930
 Val Ser Pro Glu Asp Leu Ala Thr Pro Ile Gly Arg Leu Lys Val Ser
            1145                1150                1155

 ctt caa gca gct gct gtc ctc cat gct att tac aag gag atg act gaa     3978
 Leu Gln Ala Ala Ala Val Leu His Ala Ile Tyr Lys Glu Met Thr Glu
        1160                1165                1170

 gat ttg ttt tca tga                                                 3993
 Asp Leu Phe Ser 
    1175





      <210> 10
      <211> 1392
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (60)..(1349)

      <400> 10
 ggcggtctga gagaccggtt cacgtgcagg cagcggcgga tcatattcct tcatctacc      59                                                                 
 atg gct cag ccg gga act ctg aac ctc aat aac gag gtt gtg aag atg      107
 Met Ala Gln Pro Gly Thr Leu Asn Leu Asn Asn Glu Val Val Lys Met
   1               5                  10                  15

 aga aaa gaa gtg aag aga att cga gtt tta gtt atc cga aaa ctt gtc      155
 Arg Lys Glu Val Lys Arg Ile Arg Val Leu Val Ile Arg Lys Leu Val
              20                  25                  30

 agg agt gtt ggc cga ctg aag tca aaa aag ggt act gaa gat gca ctg      203
 Arg Ser Val Gly Arg Leu Lys Ser Lys Lys Gly Thr Glu Asp Ala Leu
          35                  40                  45

 tta aaa aac caa aga cgg gcg caa aga ttg ctt gaa gaa atc cat gcc      251
 Leu Lys Asn Gln Arg Arg Ala Gln Arg Leu Leu Glu Glu Ile His Ala
      50                  55                  60

 atg aag gaa ttg aaa cct gac ata gta act aaa tct gct ctt ggt gat      299
 Met Lys Glu Leu Lys Pro Asp Ile Val Thr Lys Ser Ala Leu Gly Asp
  65                  70                  75                  80

 gat atc aac ttt gaa aaa atc ttc aaa aag cca gat tct act gca act      347
 Asp Ile Asn Phe Glu Lys Ile Phe Lys Lys Pro Asp Ser Thr Ala Thr
                  85                  90                  95

 gaa aga gca att gcc aga cta gca gta cat cct ctt ctg aag aaa aag      395
 Glu Arg Ala Ile Ala Arg Leu Ala Val His Pro Leu Leu Lys Lys Lys
             100                 105                 110

 ata gat gtg cta aaa gct gct gta caa gcc ttt aaa gaa gca aga caa      443
 Ile Asp Val Leu Lys Ala Ala Val Gln Ala Phe Lys Glu Ala Arg Gln
         115                 120                 125

 aat gtt gct gaa gtt gag tca tca aag aat gct tca gag gac aat cat      491
 Asn Val Ala Glu Val Glu Ser Ser Lys Asn Ala Ser Glu Asp Asn His
     130                 135                 140

 tct gag aat act ttg tat tca aat gat aat gga agt aat tta cag cgt      539
 Ser Glu Asn Thr Leu Tyr Ser Asn Asp Asn Gly Ser Asn Leu Gln Arg
 145                 150                 155                 160

 gaa gca act gtc atc agt gag caa aaa gtc aaa gaa acc aaa ata ttg      587
 Glu Ala Thr Val Ile Ser Glu Gln Lys Val Lys Glu Thr Lys Ile Leu
                 165                 170                 175

 gcg aag aaa cca ata cat aat tca aag gaa aaa ata gca aag atg gaa      635
 Ala Lys Lys Pro Ile His Asn Ser Lys Glu Lys Ile Ala Lys Met Glu
             180                 185                 190

 cat gga cct aaa gca gtg act att gca aat tct cca tca aag cct tca      683
 His Gly Pro Lys Ala Val Thr Ile Ala Asn Ser Pro Ser Lys Pro Ser
         195                 200                 205

 gaa aag gat tct gta gtt tcc ctt gag tcc cag aag aca cct gct gac      731
 Glu Lys Asp Ser Val Val Ser Leu Glu Ser Gln Lys Thr Pro Ala Asp
     210                 215                 220

 cca aaa ctg aaa act cta agt caa acc aaa aaa aac aaa gga tct gat      779
 Pro Lys Leu Lys Thr Leu Ser Gln Thr Lys Lys Asn Lys Gly Ser Asp
 225                 230                 235                 240

 agc tca ctc tct ggt aac agt gat ggc gga gaa gaa ttt tgt gaa gag      827
 Ser Ser Leu Ser Gly Asn Ser Asp Gly Gly Glu Glu Phe Cys Glu Glu
                 245                 250                 255

 gag aag gaa tat ttt gat gat agc aca gaa gaa agg ttt tac aag cag      875
 Glu Lys Glu Tyr Phe Asp Asp Ser Thr Glu Glu Arg Phe Tyr Lys Gln
             260                 265                 270

 tct tcc atg tct gaa gat agt gat agc ggt gac gac ttc ttc att ggg      923
 Ser Ser Met Ser Glu Asp Ser Asp Ser Gly Asp Asp Phe Phe Ile Gly
         275                 280                 285

 aaa gtc aga cgg aca cga aag aag gaa agt agt tgt cat tct tca gtt      971
 Lys Val Arg Arg Thr Arg Lys Lys Glu Ser Ser Cys His Ser Ser Val
     290                 295                 300

 aag gaa caa aaa cca cta gaa aaa gtg ttt ctt aaa gaa gat aca ggt     1019
 Lys Glu Gln Lys Pro Leu Glu Lys Val Phe Leu Lys Glu Asp Thr Gly
 305                 310                 315                 320

 gaa act cat ggg gat aca aga aat gac aaa atc aag cca agt aca gaa     1067
 Glu Thr His Gly Asp Thr Arg Asn Asp Lys Ile Lys Pro Ser Thr Glu
                 325                 330                 335

 acc aga aag tta gaa tca gtg ttt ttc cac tct tta tct gga tct aaa     1115
 Thr Arg Lys Leu Glu Ser Val Phe Phe His Ser Leu Ser Gly Ser Lys
             340                 345                 350

 agc tct aga aga aat ttc aaa gaa cag gct cca aaa aca aga tcc cta     1163
 Ser Ser Arg Arg Asn Phe Lys Glu Gln Ala Pro Lys Thr Arg Ser Leu
         355                 360                 365

 gat ttt cca cag aat gag cct cag atc aag aat cag ttt aat aag aag     1211
 Asp Phe Pro Gln Asn Glu Pro Gln Ile Lys Asn Gln Phe Asn Lys Lys
     370                 375                 380

 cta tca gga aga ctt gaa aat aca aaa cag caa ttg cag ctg cct ctt     1259
 Leu Ser Gly Arg Leu Glu Asn Thr Lys Gln Gln Leu Gln Leu Pro Leu
 385                 390                 395                 400

 cat cct tca tgg gaa gca agc aga agg cga aaa gaa cag caa tct aat     1307
 His Pro Ser Trp Glu Ala Ser Arg Arg Arg Lys Glu Gln Gln Ser Asn
                 405                 410                 415

 att gct gtg ttt cag ggg aaa aaa att acg ttt gat gat tga ttagtgc     1356
 Ile Ala Val Phe Gln Gly Lys Lys Ile Thr Phe Asp Asp 
             420                 425

 ctctttctgc aaacttttcc atctaaaaaa aaaaaa                             1392




      <210> 11
      <211> 750
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (103)..(750)

      <400> 11
 atgaggacac agaatgggac agcctcacct atcagcgctt ccttcctggg cagggctgag     60

 gattcactca ctgcccacgg ccggctgagc agggacagga ga   atg aga ggc ctc     114
                                                  Met Arg Gly Leu
                                                    1

 cgc tgg cgt tac act cgg ctg ccc agc cag gtg gag gac acc ctg tct      162
 Arg Trp Arg Tyr Thr Arg Leu Pro Ser Gln Val Glu Asp Thr Leu Ser
   5                  10                  15                  20

 ggg gag gag ggt aac gaa gag gaa gag gag gag gag gca gct cca gac      210
 Gly Glu Glu Gly Asn Glu Glu Glu Glu Glu Glu Glu Ala Ala Pro Asp
                  25                  30                  35

 cca gct gct gct cct gag gat ccc acg gtg ccc cag ctg aca gaa gcc      258
 Pro Ala Ala Ala Pro Glu Asp Pro Thr Val Pro Gln Leu Thr Glu Ala
              40                  45                  50

 agc cag gtt ttg agt gcc tca gag att cgg cag ctc agc ttt cac ttc      306
 Ser Gln Val Leu Ser Ala Ser Glu Ile Arg Gln Leu Ser Phe His Phe
          55                  60                  65

 cca cca aga gtc acc ggc cat ccc tgg agt ctg gtc ttc tgc acg tca      354
 Pro Pro Arg Val Thr Gly His Pro Trp Ser Leu Val Phe Cys Thr Ser
      70                  75                  80

 agg gac ggt ttc agc ctg cag agc ctg tac cgg cgg atg gag ggc tgc      402
 Arg Asp Gly Phe Ser Leu Gln Ser Leu Tyr Arg Arg Met Glu Gly Cys
  85                  90                  95                 100

 agc ggg cca gtg ctg ctg gtg ctc agg gac cag gac ggg cag ata ttt      450
 Ser Gly Pro Val Leu Leu Val Leu Arg Asp Gln Asp Gly Gln Ile Phe
                 105                 110                 115

 gga gcc ttc tcc tcc tcg gct atc cga ctc agc aaa ggc ttc tat ggt      498
 Gly Ala Phe Ser Ser Ser Ala Ile Arg Leu Ser Lys Gly Phe Tyr Gly
             120                 125                 130

 act ggc gag aca ttc ctc ttc tcc ttc tcc cca cag ctg aag gtc ttt      546
 Thr Gly Glu Thr Phe Leu Phe Ser Phe Ser Pro Gln Leu Lys Val Phe
         135                 140                 145

 aag tgg act gga agc aac tct ttc ttt gtg aag gga gac ttg gat tca      594
 Lys Trp Thr Gly Ser Asn Ser Phe Phe Val Lys Gly Asp Leu Asp Ser
     150                 155                 160

 ctg atg atg ggc agt ggc agt ggc cgg ttt ggg ctg tgg ttg gat gga      642
 Leu Met Met Gly Ser Gly Ser Gly Arg Phe Gly Leu Trp Leu Asp Gly
 165                 170                 175                 180

 gac ttg ttc cgc ggg gga agc tcc cct tgc ccg acc ttc aac aac gag      690
 Asp Leu Phe Arg Gly Gly Ser Ser Pro Cys Pro Thr Phe Asn Asn Glu
                 185                 190                 195

 gtg ctg gcc cgg cag gag cag ttc tgc atc cag gag ctg gag gct tgg      738
 Val Leu Ala Arg Gln Glu Gln Phe Cys Ile Gln Glu Leu Glu Ala Trp
             200                 205                 210

 ctt ctc agc tga                                                      750
 Leu Leu Ser 
         215





      <210> 12
      <211> 907
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(402)

      <400> 12
  atg ctg cca aag ttc aac ccc aaa gag atc aaa gtc gta tac ctg agg      48
  Met Leu Pro Lys Phe Asn Pro Lys Glu Ile Lys Val Val Tyr Leu Arg
    1               5                  10                  15

 tgc act ggg ggt gaa att ggc ccc ctg ggt ctg tct cca aaa aaa gtt       96
 Cys Thr Gly Gly Glu Ile Gly Pro Leu Gly Leu Ser Pro Lys Lys Val
              20                  25                  30

 ggt gat gac att gcc aag gca acg ggt gac tgg aag ggc ctg agg att      144
 Gly Asp Asp Ile Ala Lys Ala Thr Gly Asp Trp Lys Gly Leu Arg Ile
          35                  40                  45

 aca gtg aaa ctg acc att cag aac aga cag gcc cag att gag gtg gtg      192
 Thr Val Lys Leu Thr Ile Gln Asn Arg Gln Ala Gln Ile Glu Val Val
      50                  55                  60

 cct tct gcc tct gcc ctg atc atc aaa gcc ctc aag gaa cca cca aga      240
 Pro Ser Ala Ser Ala Leu Ile Ile Lys Ala Leu Lys Glu Pro Pro Arg
  65                  70                  75                  80

 gac aga aag aaa cag aaa aac att aaa cac agt ggg aat atc act ttt      288
 Asp Arg Lys Lys Gln Lys Asn Ile Lys His Ser Gly Asn Ile Thr Phe
                  85                  90                  95

 gat gag att gtc aac att gct cga cag atg cgg cac cga tcc tta gcc      336
 Asp Glu Ile Val Asn Ile Ala Arg Gln Met Arg His Arg Ser Leu Ala
             100                 105                 110

 aga gaa ctc tct ggt gag agc agg aca aca tgt aac cgc cat aac tgt      384
 Arg Glu Leu Ser Gly Glu Ser Arg Thr Thr Cys Asn Arg His Asn Cys
         115                 120                 125

 agt tgt gtt ttt cac tga gtgata acattcttct tacttgaagg gtgctcagtg      438
 Ser Cys Val Phe His 
     130

 agacccaaga tggggtgcag ttttctggga ctgaaaggat ggatcgtaaa ttggatgtgt    498

 ttaatctggg catcaaggac ccatggaagc tttgcattcc gggttatgga actagatgga    558

 actctatatt ctatattagg ggagcaggaa cctcattcct tccattgcct gctatgaacc    618

 ccttcagtat tcaccagtat ctccagattg tgagggactg agccagcacc tccgatgcca    678

 ccatttcttt actcaaggaa ccaccaagag acagaaagaa acagaaaaac attaaacaca    738

 gtgggaatat cacttttgat gagattgtca acattgctcg acagatgcgg caccgatcct    798

 tagccagaga actctctgga accattaaag agatcctggg gactgcccag tcagtgggct    858

 gtaatgttga tggccgccat cctcatgacg tcatcgaaga accaattag                907




      <210> 13
      <211> 5507
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (261)..(4817)

      <400> 13
 ccgggtcgac gatttcgttt atctgccttc ttggccataa aaggctggtt gtgtggcctg     60

 acattcgact gcctgaccac atgcattatt tttgaactgg cccccagggt cctgtcttta    120

 gccctgcctc ttaacattgt cttggattca acctaggtgg agtcttcatt ctctcatcca    180

 gctcctcggc ctcatcggaa catttccacc accattactc ctttggaaac tggtggcccg    240

 gttccttcaa gaggcacagg    atg tct ttg cct ttt tat cag agg tgc cac     290
                          Met Ser Leu Pro Phe Tyr Gln Arg Cys His
                            1               5                  10

 cag cac tat gat ctc agc tac cgc aac aag gac gtg cgc agc acc gtg      338
 Gln His Tyr Asp Leu Ser Tyr Arg Asn Lys Asp Val Arg Ser Thr Val
                  15                  20                  25

 agt cac tac cag cgg gag aag aaa cgc tcc gcc gtc tac acc cag ggc      386
 Ser His Tyr Gln Arg Glu Lys Lys Arg Ser Ala Val Tyr Thr Gln Gly
              30                  35                  40

 tcc acg gcc tac agc agc cgc tcc tcc gcc gcg cac cgc cgg gag tcc      434
 Ser Thr Ala Tyr Ser Ser Arg Ser Ser Ala Ala His Arg Arg Glu Ser
          45                  50                  55

 gag gcc ttc cgt cgg gcg tcc gcc tcc tcc tcc cag cag cag gcc tcg      482
 Glu Ala Phe Arg Arg Ala Ser Ala Ser Ser Ser Gln Gln Gln Ala Ser
      60                  65                  70

 cag cac gcc ctg agc tct gaa gtc agt cgg aag gca gcc tca gcc tac      530
 Gln His Ala Leu Ser Ser Glu Val Ser Arg Lys Ala Ala Ser Ala Tyr
  75                  80                  85                  90

 gat tat ggc tcc tcc cat gga ctt aca gat tcc agt ctg ctg tta gat      578
 Asp Tyr Gly Ser Ser His Gly Leu Thr Asp Ser Ser Leu Leu Leu Asp
                  95                 100                 105

 gat tat tca tcc aag ttg agc ccc aaa cca aag aga gcc aag cac agc      626
 Asp Tyr Ser Ser Lys Leu Ser Pro Lys Pro Lys Arg Ala Lys His Ser
             110                 115                 120

 cta ctg tct gga gaa gag aaa gaa aat ttg ccc agt gac tac atg gta      674
 Leu Leu Ser Gly Glu Glu Lys Glu Asn Leu Pro Ser Asp Tyr Met Val
         125                 130                 135

 ccc att ttc tca gga cgt caa aag cat gtc agt gga att act gat acg      722
 Pro Ile Phe Ser Gly Arg Gln Lys His Val Ser Gly Ile Thr Asp Thr
     140                 145                 150

 gaa gaa gaa aga att aag gaa gct gct gct tat ata gcc cag agg aat      770
 Glu Glu Glu Arg Ile Lys Glu Ala Ala Ala Tyr Ile Ala Gln Arg Asn
 155                 160                 165                 170

 ctt ctt gct agt gag gaa gga atc aca aca cct aaa cag tcc acg gca      818
 Leu Leu Ala Ser Glu Glu Gly Ile Thr Thr Pro Lys Gln Ser Thr Ala
                 175                 180                 185

 tcc aag cag acc acg gca tct aag cag tcc acg gca tcc aag cag tcc      866
 Ser Lys Gln Thr Thr Ala Ser Lys Gln Ser Thr Ala Ser Lys Gln Ser
             190                 195                 200

 aca gca tcc aag cag tcc acg gca tcc agg cag tcc atg gca tcc agg      914
 Thr Ala Ser Lys Gln Ser Thr Ala Ser Arg Gln Ser Met Ala Ser Arg
         205                 210                 215

 cag tct gtg gtt tcc aaa cag gcc aca tcc gct ctt caa cag gaa gaa      962
 Gln Ser Val Val Ser Lys Gln Ala Thr Ser Ala Leu Gln Gln Glu Glu
     220                 225                 230

 act tct gaa aag aag tca agg aaa gtt gtg att cga gaa aag gca gaa     1010
 Thr Ser Glu Lys Lys Ser Arg Lys Val Val Ile Arg Glu Lys Ala Glu
 235                 240                 245                 250

 cgc ctg tcc ctg agg aaa aca tta gaa gaa acc gag aca tat cat gcc     1058
 Arg Leu Ser Leu Arg Lys Thr Leu Glu Glu Thr Glu Thr Tyr His Ala
                 255                 260                 265

 aag ctg aat gaa gac cat ctt ctc cat gct cct gag ttt atc att aaa     1106
 Lys Leu Asn Glu Asp His Leu Leu His Ala Pro Glu Phe Ile Ile Lys
             270                 275                 280

 cct cgc tcc cac acg gtt tgg gag aag gag aat gta aaa ttg cat tgc     1154
 Pro Arg Ser His Thr Val Trp Glu Lys Glu Asn Val Lys Leu His Cys
         285                 290                 295

 tcc ata gca gga tgg cca gaa cct cgt gtc acg tgg tat aaa aac cag     1202
 Ser Ile Ala Gly Trp Pro Glu Pro Arg Val Thr Trp Tyr Lys Asn Gln
     300                 305                 310

 gtg cca ata aat gtc cat gca aac cct gga aag tat att att gag agt     1250
 Val Pro Ile Asn Val His Ala Asn Pro Gly Lys Tyr Ile Ile Glu Ser
 315                 320                 325                 330

 cga tat gga atg cac act ctg gag att aat gca tgt gat ttt gaa gat     1298
 Arg Tyr Gly Met His Thr Leu Glu Ile Asn Ala Cys Asp Phe Glu Asp
                 335                 340                 345

 aca gct cag tac cgg gcc tcg gcg atg aat gtt aaa gga gag ctt tcg     1346
 Thr Ala Gln Tyr Arg Ala Ser Ala Met Asn Val Lys Gly Glu Leu Ser
             350                 355                 360

 gca tat gct tca gtt gtg gta aaa agg tat aag gga gag ttt gat gag     1394
 Ala Tyr Ala Ser Val Val Val Lys Arg Tyr Lys Gly Glu Phe Asp Glu
         365                 370                 375

 act cgc ttc cat gct ggg gct tcc acc atg ccc ctc agc ttt ggt gtg     1442
 Thr Arg Phe His Ala Gly Ala Ser Thr Met Pro Leu Ser Phe Gly Val
     380                 385                 390

 acc cca tat ggt tat gca tcc cgg ttt gag atc cac ttt gat gac aaa     1490
 Thr Pro Tyr Gly Tyr Ala Ser Arg Phe Glu Ile His Phe Asp Asp Lys
 395                 400                 405                 410

 ttt gat gtg tct ttt ggg aga gag gga gag aca atg agt cta ggc tgt     1538
 Phe Asp Val Ser Phe Gly Arg Glu Gly Glu Thr Met Ser Leu Gly Cys
                 415                 420                 425

 cgt gtt gtc atc act cct gaa att aaa cat ttc cag cca gag atc cgg     1586
 Arg Val Val Ile Thr Pro Glu Ile Lys His Phe Gln Pro Glu Ile Arg
             430                 435                 440

 tgg tac aga aat gga gta cct ctt tct cca tca aaa tgg gtg caa aca     1634
 Trp Tyr Arg Asn Gly Val Pro Leu Ser Pro Ser Lys Trp Val Gln Thr
         445                 450                 455

 ctt tgg agt gga gag cgg gca acg ctg aca ttt tcc cat ctc aac aaa     1682
 Leu Trp Ser Gly Glu Arg Ala Thr Leu Thr Phe Ser His Leu Asn Lys
     460                 465                 470

 gaa gat gaa ggc ctc tat aca atc cgt gta cgg atg gga gaa tat tat     1730
 Glu Asp Glu Gly Leu Tyr Thr Ile Arg Val Arg Met Gly Glu Tyr Tyr
 475                 480                 485                 490

 gaa caa tat agt gct tat gtc ttt gtt cga gat gct gat gca gag att     1778
 Glu Gln Tyr Ser Ala Tyr Val Phe Val Arg Asp Ala Asp Ala Glu Ile
                 495                 500                 505

 gaa gga gcc cca gct gct ccc ttg gat gtg aag tgc ttg gag gcc aac     1826
 Glu Gly Ala Pro Ala Ala Pro Leu Asp Val Lys Cys Leu Glu Ala Asn
             510                 515                 520

 aaa gat tat atc atc atc tcc tgg aaa cag cca gct gtc gat gga ggg     1874
 Lys Asp Tyr Ile Ile Ile Ser Trp Lys Gln Pro Ala Val Asp Gly Gly
         525                 530                 535

 agt cct att ctc gga tat ttt att gat aag tgt gag gtg ggc aca gat     1922
 Ser Pro Ile Leu Gly Tyr Phe Ile Asp Lys Cys Glu Val Gly Thr Asp
     540                 545                 550

 agc tgg tcg cag tgc aat gac aca cct gtg aag ttt gct cgt ttt cct     1970
 Ser Trp Ser Gln Cys Asn Asp Thr Pro Val Lys Phe Ala Arg Phe Pro
 555                 560                 565                 570

 gtc act gga ttg atc gaa ggt cgt tcc tat atc ttc cga gtt cga gct     2018
 Val Thr Gly Leu Ile Glu Gly Arg Ser Tyr Ile Phe Arg Val Arg Ala
                 575                 580                 585

 gtg aat aaa atg gga ata ggt ttc cca tct cga gtt tcc gag ccc gtg     2066
 Val Asn Lys Met Gly Ile Gly Phe Pro Ser Arg Val Ser Glu Pro Val
             590                 595                 600

 gct gct ctg gat ccg gct gag aaa gct aga ctt aaa agt cgc ccc tca     2114
 Ala Ala Leu Asp Pro Ala Glu Lys Ala Arg Leu Lys Ser Arg Pro Ser
         605                 610                 615

 gca ccc tgg act gga cag atc att gtt act gaa gag gaa cct tca gag     2162
 Ala Pro Trp Thr Gly Gln Ile Ile Val Thr Glu Glu Glu Pro Ser Glu
     620                 625                 630

 ggt att gtg cct ggc ccc ccg aca gac ctc tct gtc act gag gcc acc     2210
 Gly Ile Val Pro Gly Pro Pro Thr Asp Leu Ser Val Thr Glu Ala Thr
 635                 640                 645                 650

 cgg agc tat gtg gtg ctc agc tgg aag ccc cct ggc cag cgt ggt cat     2258
 Arg Ser Tyr Val Val Leu Ser Trp Lys Pro Pro Gly Gln Arg Gly His
                 655                 660                 665

 gag ggc att atg tac ttt gtg gaa aag tgt gag gca gga aca gaa aac     2306
 Glu Gly Ile Met Tyr Phe Val Glu Lys Cys Glu Ala Gly Thr Glu Asn
             670                 675                 680

 tgg cag cga gtg aac acg gag ctc cct gtg aag tct ccc cgc ttt gct     2354
 Trp Gln Arg Val Asn Thr Glu Leu Pro Val Lys Ser Pro Arg Phe Ala
         685                 690                 695

 ctg ttt gac ttg gcc gag ggg aaa tcc tac tgt ttc cgt gtc cgc tgt     2402
 Leu Phe Asp Leu Ala Glu Gly Lys Ser Tyr Cys Phe Arg Val Arg Cys
     700                 705                 710

 tct aat tct gca gga gtt ggt gag ccc tca gag gca acg gag gtg act     2450
 Ser Asn Ser Ala Gly Val Gly Glu Pro Ser Glu Ala Thr Glu Val Thr
 715                 720                 725                 730

 gtg gta ggg gac aaa ctt gat atc ccc aag gct cct ggc aaa atc atc     2498
 Val Val Gly Asp Lys Leu Asp Ile Pro Lys Ala Pro Gly Lys Ile Ile
                 735                 740                 745

 cca agc aga aac aca gac acc tca gtg gta gtt tcg tgg gag gag tcc     2546
 Pro Ser Arg Asn Thr Asp Thr Ser Val Val Val Ser Trp Glu Glu Ser
             750                 755                 760

 aaa gat gcc aaa gag ctg gtc ggg tac tac ata gag gcg agc gtt gct     2594
 Lys Asp Ala Lys Glu Leu Val Gly Tyr Tyr Ile Glu Ala Ser Val Ala
         765                 770                 775

 ggc tct ggc aag tgg gag ccc tgt aac aac aac ccc gtg aag ggc tca     2642
 Gly Ser Gly Lys Trp Glu Pro Cys Asn Asn Asn Pro Val Lys Gly Ser
     780                 785                 790

 cga ttc act tgt cat gga tta gtg act ggt cag agt tat att ttc cgg     2690
 Arg Phe Thr Cys His Gly Leu Val Thr Gly Gln Ser Tyr Ile Phe Arg
 795                 800                 805                 810

 gtc aga gca gtc aat gca gct gga ctt agt gaa tat tcc cag gat tca     2738
 Val Arg Ala Val Asn Ala Ala Gly Leu Ser Glu Tyr Ser Gln Asp Ser
                 815                 820                 825

 gaa gct att gaa gtc aaa gct gct att gca cca cca tct cca ccc tgt     2786
 Glu Ala Ile Glu Val Lys Ala Ala Ile Ala Pro Pro Ser Pro Pro Cys
             830                 835                 840

 gat atc acc tgt ctt gaa agt ttt cgt gac tca atg gtt ctt gga tgg     2834
 Asp Ile Thr Cys Leu Glu Ser Phe Arg Asp Ser Met Val Leu Gly Trp
         845                 850                 855

 aag caa cca gat aag att gga ggg gca gaa att act ggc tat tat gtg     2882
 Lys Gln Pro Asp Lys Ile Gly Gly Ala Glu Ile Thr Gly Tyr Tyr Val
     860                 865                 870

 aac tat cgc gag gtc att gat ggg gta cca gga aaa tgg aga gaa gcc     2930
 Asn Tyr Arg Glu Val Ile Asp Gly Val Pro Gly Lys Trp Arg Glu Ala
 875                 880                 885                 890

 aat gtc aag gct gtc agt gag gag gca tac aag att agc aac ttg aag     2978
 Asn Val Lys Ala Val Ser Glu Glu Ala Tyr Lys Ile Ser Asn Leu Lys
                 895                 900                 905

 gaa aac atg gtg tat cag ttc caa gtg gca gcc atg aac atg gct ggg     3026
 Glu Asn Met Val Tyr Gln Phe Gln Val Ala Ala Met Asn Met Ala Gly
             910                 915                 920

 ctg ggc gcg ccc tcc gca gta agc gaa tgc ttc aaa tgt gaa gag tgg     3074
 Leu Gly Ala Pro Ser Ala Val Ser Glu Cys Phe Lys Cys Glu Glu Trp
         925                 930                 935

 acc atc gcc gtc cca gga cca ccg cac agt ctc aag tgt agt gaa gtc     3122
 Thr Ile Ala Val Pro Gly Pro Pro His Ser Leu Lys Cys Ser Glu Val
     940                 945                 950

 agg aaa gac tca ctg gtt ctc cag tgg aag ccg cca gtc cac tcc ggg     3170
 Arg Lys Asp Ser Leu Val Leu Gln Trp Lys Pro Pro Val His Ser Gly
 955                 960                 965                 970

 cgg act ccg gtc act ggt tac ttc gtg gac ttg aag gag gcc aag gcc     3218
 Arg Thr Pro Val Thr Gly Tyr Phe Val Asp Leu Lys Glu Ala Lys Ala
                 975                 980                 985

 aaa gaa gac cag tgg cga ggg ctc aat gag gcg gct att aaa aac gta     3266
 Lys Glu Asp Gln Trp Arg Gly Leu Asn Glu Ala Ala Ile Lys Asn Val
             990                 995                1000

 tac ctg aag gtt cga ggc ctc aag gag ggc gtc agc tac gtg ttc cgt     3314
 Tyr Leu Lys Val Arg Gly Leu Lys Glu Gly Val Ser Tyr Val Phe Arg
        1005                1010                1015

 gtt cga gcc ata aac cag gcg gga gtt ggg aag cca tct gac ctt gct     3362
 Val Arg Ala Ile Asn Gln Ala Gly Val Gly Lys Pro Ser Asp Leu Ala
    1020                1025                1030

 ggc cct gtt gtg gca gag acc cgt cca gga agg aaa gag gtt gtt gta     3410
 Gly Pro Val Val Ala Glu Thr Arg Pro Gly Arg Lys Glu Val Val Val
1035                1040                1045                1050

 aat gtg gat gat gat gga gtc att tca ttg aac ttc gag tgt gat aag     3458
 Asn Val Asp Asp Asp Gly Val Ile Ser Leu Asn Phe Glu Cys Asp Lys
                1055                1060                1065

 atg act cca aag tcc gag ttc tcc tgg tcc aaa gat tat gta tcc act     3506
 Met Thr Pro Lys Ser Glu Phe Ser Trp Ser Lys Asp Tyr Val Ser Thr
            1070                1075                1080

 gag gac tct cca cga ttg gaa gtc gaa agc aag ggc aac aag acg aaa     3554
 Glu Asp Ser Pro Arg Leu Glu Val Glu Ser Lys Gly Asn Lys Thr Lys
        1085                1090                1095

 atg acc ttc aaa gac ctt ggg atg gat gac ttg ggt att tac tct tgc     3602
 Met Thr Phe Lys Asp Leu Gly Met Asp Asp Leu Gly Ile Tyr Ser Cys
    1100                1105                1110

 gat gta aca gac act gat gga ata gca tca agc tac tta ata gat gag     3650
 Asp Val Thr Asp Thr Asp Gly Ile Ala Ser Ser Tyr Leu Ile Asp Glu
1115                1120                1125                1130

 gaa gaa ttg aaa cgt tta ctt gct ctc agc cat gaa cac aag ttc cca     3698
 Glu Glu Leu Lys Arg Leu Leu Ala Leu Ser His Glu His Lys Phe Pro
                1135                1140                1145

 act gtc cca gtt aaa tca gag ttg gca gtt gaa att ttg gag aaa ggc     3746
 Thr Val Pro Val Lys Ser Glu Leu Ala Val Glu Ile Leu Glu Lys Gly
            1150                1155                1160

 cag gtc cgg ttt tgg atg cag gct gag aaa ctg tct ggc aat gcc aaa     3794
 Gln Val Arg Phe Trp Met Gln Ala Glu Lys Leu Ser Gly Asn Ala Lys
        1165                1170                1175

 gtc aac tac ata ttt aac gag aag gaa att ttt gaa ggc ccg aaa tat     3842
 Val Asn Tyr Ile Phe Asn Glu Lys Glu Ile Phe Glu Gly Pro Lys Tyr
    1180                1185                1190

 aaa atg cat att gac cga aac act ggc atc atc gaa atg ttc atg gaa     3890
 Lys Met His Ile Asp Arg Asn Thr Gly Ile Ile Glu Met Phe Met Glu
1195                1200                1205                1210

 aag cta cag gat gag gat gag gga acg tac act ttc cag ctt caa gat     3938
 Lys Leu Gln Asp Glu Asp Glu Gly Thr Tyr Thr Phe Gln Leu Gln Asp
                1215                1220                1225

 gga aaa gca act aac cat tct act gtt gtt ctc gtt gga gat gtt ttc     3986
 Gly Lys Ala Thr Asn His Ser Thr Val Val Leu Val Gly Asp Val Phe
            1230                1235                1240

 aaa aag ctc cag aaa gaa gct gaa ttc cag cgg caa gaa tgg atc agg     4034
 Lys Lys Leu Gln Lys Glu Ala Glu Phe Gln Arg Gln Glu Trp Ile Arg
        1245                1250                1255

 aaa caa ggt cct cac ttt gtt gag tat ttg agc tgg gaa gtg act ggt     4082
 Lys Gln Gly Pro His Phe Val Glu Tyr Leu Ser Trp Glu Val Thr Gly
    1260                1265                1270

 gaa tgt aat gta cta ttg aaa tgc aag gtg gca aat att aag aag gag     4130
 Glu Cys Asn Val Leu Leu Lys Cys Lys Val Ala Asn Ile Lys Lys Glu
1275                1280                1285                1290

 act cat att gtg tgg tac aaa gat gag agg gag ata tca gtg gat gaa     4178
 Thr His Ile Val Trp Tyr Lys Asp Glu Arg Glu Ile Ser Val Asp Glu
                1295                1300                1305

 aag cat gac ttt aag gat ggt ata tgt acc ctg ctt ata aca gag ttt     4226
 Lys His Asp Phe Lys Asp Gly Ile Cys Thr Leu Leu Ile Thr Glu Phe
            1310                1315                1320

 tcc aag aaa gat gct ggg att tat gaa gtt atc ctg aaa gat gac cga     4274
 Ser Lys Lys Asp Ala Gly Ile Tyr Glu Val Ile Leu Lys Asp Asp Arg
        1325                1330                1335

 gga aaa gat aag agc aga ctg aag ctt gtg gat gaa gcc ttt aag gaa     4322
 Gly Lys Asp Lys Ser Arg Leu Lys Leu Val Asp Glu Ala Phe Lys Glu
    1340                1345                1350

 ctg atg atg gaa gta tgc aaa aaa ata gct ttg tct gct aca gac ctg     4370
 Leu Met Met Glu Val Cys Lys Lys Ile Ala Leu Ser Ala Thr Asp Leu
1355                1360                1365                1370

 aaa atc cag agc aca gcc gag ggc atc caa ctg tac tct ttt gta act     4418
 Lys Ile Gln Ser Thr Ala Glu Gly Ile Gln Leu Tyr Ser Phe Val Thr
                1375                1380                1385

 tac tat gtg gag gat ttg aaa gtt aac tgg tcc cac aat ggg tcc gcc     4466
 Tyr Tyr Val Glu Asp Leu Lys Val Asn Trp Ser His Asn Gly Ser Ala
            1390                1395                1400

 att agg tac tca gac aga gtt aag acc ggg gtc act gga gag cag atc     4514
 Ile Arg Tyr Ser Asp Arg Val Lys Thr Gly Val Thr Gly Glu Gln Ile
        1405                1410                1415

 tgg cta caa atc aac gag ccc acc ccg aat gac aaa ggg aag tat gtc     4562
 Trp Leu Gln Ile Asn Glu Pro Thr Pro Asn Asp Lys Gly Lys Tyr Val
    1420                1425                1430

 atg gag ctc ttt gat ggc aaa act gga cat cag aag aca gtg gat ctc     4610
 Met Glu Leu Phe Asp Gly Lys Thr Gly His Gln Lys Thr Val Asp Leu
1435                1440                1445                1450

 tct gga caa gca tac gat gag gcc tat gct gaa ttc cag agg ttg aaa     4658
 Ser Gly Gln Ala Tyr Asp Glu Ala Tyr Ala Glu Phe Gln Arg Leu Lys
                1455                1460                1465

 caa gct gcc att gcc gag aaa aat cgt gcc cgg gtg ttg gga ggt ctc     4706
 Gln Ala Ala Ile Ala Glu Lys Asn Arg Ala Arg Val Leu Gly Gly Leu
            1470                1475                1480

 cca gac gtg gtc acc atc cag gag ggg aag gcc ctt aat ctc act tgc     4754
 Pro Asp Val Val Thr Ile Gln Glu Gly Lys Ala Leu Asn Leu Thr Cys
        1485                1490                1495

 aac gtg tgg gga gac ccg cct ccg gag gtg tcg tgg ttg aag aac gag     4802
 Asn Val Trp Gly Asp Pro Pro Pro Glu Val Ser Trp Leu Lys Asn Glu
    1500                1505                1510

 aag gcc ctg gct tag acgaccactg caacctcaag ttcgaggctg ggaggaccgc     4857
 Lys Ala Leu Ala 
1515

 gtacttcacc atcaacggcg tgagcaccgc tgactcgggc aaatacgggc tggttgtgaa   4917

 gaacaagtat ggctcggaga ccagcgactt caccgtcagc gtgttcatcc cagaggagga   4977

 ggcgaggatg gccgccttgg agtccctgaa aggcggcaag aaggccaagt gaccggaggt   5037

 gcgaggagag ccagccggcc tgtgtgactt gggtgtgaat ggtttgggtt aaggatgaga   5097

 cgtcttcatg ctttctcctc cctattattt tctggcttga ggggaaaata atgtcaggtc   5157

 tttcactcat ataaaaaagc accaactaat gacactttaa ttgtttttct ttatctacaa   5217

 aattatgtgt taagaaaata ccattcatag catgaagatt aggaaacagt tttaaggaga   5277

 agacttgaat gaagttggag ggacattgaa tgatggtcag agggcagacg aatgtgtcgt   5337

 ggggcgagtt gggatttgct gcagctgtga agccatggcc gtgtctcgtg tgttgttaca   5397

 gaggtgatgt gcttttcgac gggcgcctcg tggcttggaa cctcctctgt atgaataaac   5457

 agttttcacg tctgtcctct tccccgaaaa aaaaaaaaaa aaaaaaagtt              5507




      <210> 14
      <211> 1226
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (322)..(822)

      <400> 14
 atggaacagc ccctgtggat ggggaaaggc ctgcagctgg actcaaccac tccagaggag     60

 aaccgcgttg gccgccttcc cagggagcgc cagattcccc tttgccctga ggcagggaca    120

 cgtgcttcag caggttgggt taacggcatg gagaacagtc acccccccca ccaccaccac    180

 cagcagcccc cgccgcagcc cggcccttcg ggcgagagga ggaaccacca ttggagaagt    240

 tacaagttga tgattgaccc ggctctgaaa aaggggcatc ataaactgta ccgctacgat    300

 gggcagcatt tcagcctggc g  atg tcc agc aac cgc ccg gtg gaa att gtc     351
                          Met Ser Ser Asn Arg Pro Val Glu Ile Val
                            1               5                  10

 gaa gat ccc cgg gtc gtc ggg atc tgg acc aaa aac aag gag ctg gag      399
 Glu Asp Pro Arg Val Val Gly Ile Trp Thr Lys Asn Lys Glu Leu Glu
                  15                  20                  25

 ctg tcg gtg ccc aaa ttc aag atc gat gag ttc tac gtg ggc ccg gtg      447
 Leu Ser Val Pro Lys Phe Lys Ile Asp Glu Phe Tyr Val Gly Pro Val
              30                  35                  40

 cct ccg aag cag gtg aca ttt gcc aag ctg aat gat aac atc cgt gaa      495
 Pro Pro Lys Gln Val Thr Phe Ala Lys Leu Asn Asp Asn Ile Arg Glu
          45                  50                  55

 aac ttc ctg agg gac atg tgc aag aag tat ggg gag gtg gag gag gtg      543
 Asn Phe Leu Arg Asp Met Cys Lys Lys Tyr Gly Glu Val Glu Glu Val
      60                  65                  70

 gag att ttg tac aac ccc aag acc aag aag cac ctg ggc atc gcc aag      591
 Glu Ile Leu Tyr Asn Pro Lys Thr Lys Lys His Leu Gly Ile Ala Lys
  75                  80                  85                  90

 gtg gtc ttt gcc acg gtc cgg gga gcc aag gat gcc gtt cag cac ttg      639
 Val Val Phe Ala Thr Val Arg Gly Ala Lys Asp Ala Val Gln His Leu
                  95                 100                 105

 cac agc act tcc gtc atg ggc aac att atc cac gtg gag ctg gac acc      687
 His Ser Thr Ser Val Met Gly Asn Ile Ile His Val Glu Leu Asp Thr
             110                 115                 120

 aaa ggt gag cct ggc agg gga gga gcg tgg gga gac ctg tca gcc cga      735
 Lys Gly Glu Pro Gly Arg Gly Gly Ala Trp Gly Asp Leu Ser Ala Arg
         125                 130                 135

 ccc ttt ccc tcc cca ccc ttc ctg cag cgt ggg gag gac ccc ccc tca      783
 Pro Phe Pro Ser Pro Pro Phe Leu Gln Arg Gly Glu Asp Pro Pro Ser
     140                 145                 150

 ctc ttc ctt ggg atc ccc ccc cac aac ctt att tct tag ccccctcctg       832
 Leu Phe Leu Gly Ile Pro Pro His Asn Leu Ile Ser 
 155                 160                 165

 agggtagagt cgcgtggagc taaatgtgtt gtctgttgct aggagacagt ctgtaattta    892

 ccaaatgtgc cggtccttgg ccaccgcacc cctagggacc acccggaggc ttccccatcg    952

 ctgacacccc cgcgggcccc ctctctgagc cctggtggct tgggtttaga cagtccccag   1012

 tgttgcctgt gttaggggag gagacagagt ttgtttactt gtgggggact gaggaagtgc   1072

 cactaggatg ccttgaaata catcaagaga aggtctgaaa actgaaaaga gagtcctcta   1132

 aggatccagg gtgtcccccc acctccttgc tgccccttcc cctctggaag tggcagccaa   1192

 tctggggcca ggagtgttgt ttcattgata aggg                               1226




      <210> 15
      <211> 3084
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (147)..(2702)

      <400> 15
 atgggcgccc tagcagcccc gagcgttccc agggcgcagg cgcggcgcgg cgtggcgtcg     60

 cctagcaacg aggcacaaca agggactggg ggttcgtctg ctgggtttgc ggagcagcta    120

 gctactcggc gggatctccc ggcagg atg ggt aaa aag ata aag aag gaa gta     173
                              Met Gly Lys Lys Ile Lys Lys Glu Val
                                1               5

 gag cct cct cct aag gat gtg ttt gac cca tta atg att gaa agc aaa      221
 Glu Pro Pro Pro Lys Asp Val Phe Asp Pro Leu Met Ile Glu Ser Lys
  10                  15                  20                  25

 aaa gca gca act gtg gtg tta atg ctt aat tct cca gaa gag gaa att      269
 Lys Ala Ala Thr Val Val Leu Met Leu Asn Ser Pro Glu Glu Glu Ile
                  30                  35                  40

 ttg gct aaa gca tgt gaa gcc att tat aaa ttt gct tta aaa ggt gag      317
 Leu Ala Lys Ala Cys Glu Ala Ile Tyr Lys Phe Ala Leu Lys Gly Glu
              45                  50                  55

 gaa aat aaa aca acc ctc ctt gaa ctt gga gct gtg gaa cct tta act      365
 Glu Asn Lys Thr Thr Leu Leu Glu Leu Gly Ala Val Glu Pro Leu Thr
          60                  65                  70

 aag cta ctc acc cat gaa gac aaa att gta aga aga aat gct act atg      413
 Lys Leu Leu Thr His Glu Asp Lys Ile Val Arg Arg Asn Ala Thr Met
      75                  80                  85

 ata ttt gga atc ctg gct tct aat aat gat gtt aaa aaa ttg tta agg      461
 Ile Phe Gly Ile Leu Ala Ser Asn Asn Asp Val Lys Lys Leu Leu Arg
  90                  95                 100                 105

 gag tta gat gtc atg aat tct gtc att gcc cag ctc gct cca gaa gaa      509
 Glu Leu Asp Val Met Asn Ser Val Ile Ala Gln Leu Ala Pro Glu Glu
                 110                 115                 120

 gaa gta gtt atc cat gag ttt gct agt ctt tgt cta gca aac atg tct      557
 Glu Val Val Ile His Glu Phe Ala Ser Leu Cys Leu Ala Asn Met Ser
             125                 130                 135

 gca gag tac acc agt aaa gtg caa ata ttt gaa cat ggg gga tta gag      605
 Ala Glu Tyr Thr Ser Lys Val Gln Ile Phe Glu His Gly Gly Leu Glu
         140                 145                 150

 cca ctc atc aga cta ctg agt agc cct gac ccg gat gta aag aag aac      653
 Pro Leu Ile Arg Leu Leu Ser Ser Pro Asp Pro Asp Val Lys Lys Asn
     155                 160                 165

 tct atg gaa tgc att tac aac ttg gtg cag gat ttt cag tgt cga gct      701
 Ser Met Glu Cys Ile Tyr Asn Leu Val Gln Asp Phe Gln Cys Arg Ala
 170                 175                 180                 185

 aaa ctt caa gaa cta aat gca ata cct cct atc tta gat ctc ttg aag      749
 Lys Leu Gln Glu Leu Asn Ala Ile Pro Pro Ile Leu Asp Leu Leu Lys
                 190                 195                 200

 tca gaa tat cca gtg att cag ttg ttg gct ctc aaa acc tta ggt gtt      797
 Ser Glu Tyr Pro Val Ile Gln Leu Leu Ala Leu Lys Thr Leu Gly Val
             205                 210                 215

 att gca aat gat aag gag tct cga aca atg cta aga gac aat caa gga      845
 Ile Ala Asn Asp Lys Glu Ser Arg Thr Met Leu Arg Asp Asn Gln Gly
         220                 225                 230

 ttg gac cat ctt att aag atc cta gaa act aag gaa ttg aat gac ctt      893
 Leu Asp His Leu Ile Lys Ile Leu Glu Thr Lys Glu Leu Asn Asp Leu
     235                 240                 245

 cat ata gaa gca ctt gca gtg ata gcc aat tgc ctt gaa gac atg gat      941
 His Ile Glu Ala Leu Ala Val Ile Ala Asn Cys Leu Glu Asp Met Asp
 250                 255                 260                 265

 act atg gtg cag att cag cag aca ggg ggt ctt aaa aag ctc ctg tca      989
 Thr Met Val Gln Ile Gln Gln Thr Gly Gly Leu Lys Lys Leu Leu Ser
                 270                 275                 280

 ttt gca gaa aac tct aca att cct gat att cag aag aat gca gca aaa     1037
 Phe Ala Glu Asn Ser Thr Ile Pro Asp Ile Gln Lys Asn Ala Ala Lys
             285                 290                 295

 gcc att act aaa gca gct tat gat cct gaa aat aga aaa ctt ttt cat     1085
 Ala Ile Thr Lys Ala Ala Tyr Asp Pro Glu Asn Arg Lys Leu Phe His
         300                 305                 310

 gaa caa gag gtt gaa aag tgc ctt gta gcc ctt ttg ggt tct gaa aat     1133
 Glu Gln Glu Val Glu Lys Cys Leu Val Ala Leu Leu Gly Ser Glu Asn
     315                 320                 325

 gat gga act aaa att gct gct tcc caa gct att tca gca atg tgt gag     1181
 Asp Gly Thr Lys Ile Ala Ala Ser Gln Ala Ile Ser Ala Met Cys Glu
 330                 335                 340                 345

 aat tca ggc agc aaa gat ttt ttc aat aat cag ggg att cca cag tta     1229
 Asn Ser Gly Ser Lys Asp Phe Phe Asn Asn Gln Gly Ile Pro Gln Leu
                 350                 355                 360

 att cag ttg cta aaa agt gac aat gaa gag gta cgg gaa gca gca gct     1277
 Ile Gln Leu Leu Lys Ser Asp Asn Glu Glu Val Arg Glu Ala Ala Ala
             365                 370                 375

 cta gcc ctg gca aac cta acc act tgc aac cct gct aat gca aat cac     1325
 Leu Ala Leu Ala Asn Leu Thr Thr Cys Asn Pro Ala Asn Ala Asn His
         380                 385                 390

 agc gac cca gga ggt gtt aga cac act ctt ggg atc cag gac tgt act     1373
 Ser Asp Pro Gly Gly Val Arg His Thr Leu Gly Ile Gln Asp Cys Thr
     395                 400                 405

 ggc tgc tgg agg aga gtg gag gaa agg gtg ggg tgg ggg gaa ggg cac     1421
 Gly Cys Trp Arg Arg Val Glu Glu Arg Val Gly Trp Gly Glu Gly His
 410                 415                 420                 425

 aac ctc tgg tgt aag cca cag aac aag aag aca ctt tct ctg ctg ttg     1469
 Asn Leu Trp Cys Lys Pro Gln Asn Lys Lys Thr Leu Ser Leu Leu Leu
                 430                 435                 440

 aga agc agg ttc ctg gaa ggc ctt cat gtg tta tta ctg gtt gga cag     1517
 Arg Ser Arg Phe Leu Glu Gly Leu His Val Leu Leu Leu Val Gly Gln
             445                 450                 455

 aga aga gca ctg cca gcc cca gat ggg agt gag aag gcc ggt cgg gga     1565
 Arg Arg Ala Leu Pro Ala Pro Asp Gly Ser Glu Lys Ala Gly Arg Gly
         460                 465                 470

 gaa ggt aag caa ttg aga agg cgg aag ggg caa aag gaa act gga gag     1613
 Glu Gly Lys Gln Leu Arg Arg Arg Lys Gly Gln Lys Glu Thr Gly Glu
     475                 480                 485

 ggc ggc agg aag aga gaa aag gaa gag agc aga ggc gtg gag aag agg     1661
 Gly Gly Arg Lys Arg Glu Lys Glu Glu Ser Arg Gly Val Glu Lys Arg
 490                 495                 500                 505

 aaa aga gga ggg cgg gga aag ggg agg ctg cgt ttt gca gga ctg ggc     1709
 Lys Arg Gly Gly Arg Gly Lys Gly Arg Leu Arg Phe Ala Gly Leu Gly
                 510                 515                 520

 agc tcc aga gac agt gga aca ccg gtg tct ttt tgg acc cta tgc gct     1757
 Ser Ser Arg Asp Ser Gly Thr Pro Val Ser Phe Trp Thr Leu Cys Ala
             525                 530                 535

 gct gct gaa gct gat ggt att gat cca tta ata aac ctc ctg tct agt     1805
 Ala Ala Glu Ala Asp Gly Ile Asp Pro Leu Ile Asn Leu Leu Ser Ser
         540                 545                 550

 aaa cga gat gga gcc att gcc aac gct gct aca gta tta aca aac atg     1853
 Lys Arg Asp Gly Ala Ile Ala Asn Ala Ala Thr Val Leu Thr Asn Met
     555                 560                 565

 gcc atg cag gag ccc ctg cgc ctg aac ata cag aat cac gac atc atg     1901
 Ala Met Gln Glu Pro Leu Arg Leu Asn Ile Gln Asn His Asp Ile Met
 570                 575                 580                 585

 cat gcc atc atc agc cca ctg cgt tct gca aac aca gtc gtg cag agc     1949
 His Ala Ile Ile Ser Pro Leu Arg Ser Ala Asn Thr Val Val Gln Ser
                 590                 595                 600

 aaa gct gct ctc gct gtc acc gca act gcg tgt gac gtt gaa gcc cgg     1997
 Lys Ala Ala Leu Ala Val Thr Ala Thr Ala Cys Asp Val Glu Ala Arg
             605                 610                 615

 act gag tta aga aat tct ggt gga ttg gag ccc ctg gta gag ctg cta     2045
 Thr Glu Leu Arg Asn Ser Gly Gly Leu Glu Pro Leu Val Glu Leu Leu
         620                 625                 630

 cgc tcc aag aat gat gaa gtg agg aag cac gcc agt tgg gca gtg atg     2093
 Arg Ser Lys Asn Asp Glu Val Arg Lys His Ala Ser Trp Ala Val Met
     635                 640                 645

 gtc tgt gct ggt gac gag ctg acg gcc aat gaa tta tgc agg ctc ggg     2141
 Val Cys Ala Gly Asp Glu Leu Thr Ala Asn Glu Leu Cys Arg Leu Gly
 650                 655                 660                 665

 gct tta gat atc ctt gaa gaa gtt aac gta tca gga act cgg aaa aat     2189
 Ala Leu Asp Ile Leu Glu Glu Val Asn Val Ser Gly Thr Arg Lys Asn
                 670                 675                 680

 aaa ttc agt gag gca gct tat aat aag ttg ctc aat aac aat ctt tcc     2237
 Lys Phe Ser Glu Ala Ala Tyr Asn Lys Leu Leu Asn Asn Asn Leu Ser
             685                 690                 695

 ctg aaa tac agc cag act ggc tat ttg tca tca agt aac ata att aac     2285
 Leu Lys Tyr Ser Gln Thr Gly Tyr Leu Ser Ser Ser Asn Ile Ile Asn
         700                 705                 710

 gat gga ttc tat gat tat ggt cgg ata aat ccc ggc acc aaa ctg ttg     2333
 Asp Gly Phe Tyr Asp Tyr Gly Arg Ile Asn Pro Gly Thr Lys Leu Leu
     715                 720                 725

 cct ttg aag gag ctc tgc tta caa gaa cca agt gac cta cgg gct gta     2381
 Pro Leu Lys Glu Leu Cys Leu Gln Glu Pro Ser Asp Leu Arg Ala Val
 730                 735                 740                 745

 ctc tta atc aac agt aaa tct tac gtt tct cca cct tca tct atg gaa     2429
 Leu Leu Ile Asn Ser Lys Ser Tyr Val Ser Pro Pro Ser Ser Met Glu
                 750                 755                 760

 gat aaa tca gat gtt ggt tat gga cga agt att tct tct tca tct tcc     2477
 Asp Lys Ser Asp Val Gly Tyr Gly Arg Ser Ile Ser Ser Ser Ser Ser
             765                 770                 775

 tta aga aga tca agt aaa gaa aag aat aaa aaa aat agt tat cat ttt     2525
 Leu Arg Arg Ser Ser Lys Glu Lys Asn Lys Lys Asn Ser Tyr His Phe
         780                 785                 790

 agt gct gga ttt gga tct ccc ata gaa gac aaa tca gag cca gct tct     2573
 Ser Ala Gly Phe Gly Ser Pro Ile Glu Asp Lys Ser Glu Pro Ala Ser
     795                 800                 805

 gga cga aat act gtt ctc agc aaa agc gcc acc aaa gaa aaa gga tgg     2621
 Gly Arg Asn Thr Val Leu Ser Lys Ser Ala Thr Lys Glu Lys Gly Trp
 810                 815                 820                 825

 agg aaa agc aaa ggg aaa aaa aga aga gga aaa agt gaa aga gga gga     2669
 Arg Lys Ser Lys Gly Lys Lys Arg Arg Gly Lys Ser Glu Arg Gly Gly
                 830                 835                 840

 aga ggt tat ggt ggt acc aaa att tgt tgg tga aggaagct ctgacaaaga     2720
 Arg Gly Tyr Gly Gly Thr Lys Ile Cys Trp 
             845                 850

 atggtgtcct ccctctgacc ctgatttctc tatgtatgtg tatgaggtga ccaaatcaat   2780

 actgccaata accaatatta aggaacagat tgaggatctg gcaaagtcat acgttcacta   2840

 agaatcagag atagcagctg gaaattgctt caagaaaaat gcctgtcatt ttcttcagct   2900

 agaccatgaa aagcatcttt caatgtgatc ctgcagaagt tatgaatgaa tcaaaagttt   2960

 gaagattaaa tcatccctta ggtggatggg gtgttcataa gttaaaggaa tcctactgtg   3020

 aattatttgt aaactgataa attttctaat acaaatgtca aaaaaaaaaa aaaaaaaaaa   3080

 aaag                                                                3084




      <210> 16
      <211> 2025
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (70)..(1827)

      <400> 16
 aaggatcctt aattaaatta atcccccccc tcttggcccg cgtttccccg gcaacccgcg     60

 gccgccgcc    atg gac gcg ctg ttg ggc aca ggg cct cgc cgg gct cgc     108
              Met Asp Ala Leu Leu Gly Thr Gly Pro Arg Arg Ala Arg
                1               5                  10

 ggc tgc ctg ggc gcg gct gga ccc acg tct tca ggt cgc gcg gcg cgg      156
 Gly Cys Leu Gly Ala Ala Gly Pro Thr Ser Ser Gly Arg Ala Ala Arg
      15                  20                  25

 acc ccg gcg gcg ccc tgg gcg cgc ttc tcc gcc tgg ctg gag tgt gtg      204
 Thr Pro Ala Ala Pro Trp Ala Arg Phe Ser Ala Trp Leu Glu Cys Val
  30                  35                  40                  45

 tgc gtg gtc acc ttc gac ctg gag ctg ggc cag gcg ctg gag ctg gtg      252
 Cys Val Val Thr Phe Asp Leu Glu Leu Gly Gln Ala Leu Glu Leu Val
                  50                  55                  60

 tat ccg aac gac ttt ccg ctc aca gac gag gag aaa agc agc atc tgc      300
 Tyr Pro Asn Asp Phe Pro Leu Thr Asp Glu Glu Lys Ser Ser Ile Cys
              65                  70                  75

 tac ctg tct ttt ccc gac tcg cac tca ggc tgc ctt gga gac act cag      348
 Tyr Leu Ser Phe Pro Asp Ser His Ser Gly Cys Leu Gly Asp Thr Gln
          80                  85                  90

 ttc agc ttc cgc atg cgc cag tgt gga ggg cag agg agc ccc tgg cat      396
 Phe Ser Phe Arg Met Arg Gln Cys Gly Gly Gln Arg Ser Pro Trp His
      95                 100                 105

 gcc gac gac agg cac tac aac agc agg gcc cct gtg gca ctg cag agg      444
 Ala Asp Asp Arg His Tyr Asn Ser Arg Ala Pro Val Ala Leu Gln Arg
 110                 115                 120                 125

 gag ccg gca cac tac ttt ggc tac gtg tac ttc agg cag gtg aag gac      492
 Glu Pro Ala His Tyr Phe Gly Tyr Val Tyr Phe Arg Gln Val Lys Asp
                 130                 135                 140

 agc tct gtg aag agg ggc tac ttc cag aag tct ttg gtg ctg gtg tcc      540
 Ser Ser Val Lys Arg Gly Tyr Phe Gln Lys Ser Leu Val Leu Val Ser
             145                 150                 155

 cgc ttg ccc ttt gtc cgg ctg ttc caa gcg ctg cta agc ctc atc gcc      588
 Arg Leu Pro Phe Val Arg Leu Phe Gln Ala Leu Leu Ser Leu Ile Ala
         160                 165                 170

 ccc gag tac ttt gac aag ctg gcg ccc tgc ctg gaa gca gtg tgc agt      636
 Pro Glu Tyr Phe Asp Lys Leu Ala Pro Cys Leu Glu Ala Val Cys Ser
     175                 180                 185

 gag atc gac cag tgg ccg gcg cct gcg cct ggg cag acc ctg aac cta      684
 Glu Ile Asp Gln Trp Pro Ala Pro Ala Pro Gly Gln Thr Leu Asn Leu
 190                 195                 200                 205

 cct gtc atg ggc gtt gtt gtc cag gtg cgc atc cca tcc agg gtg gac      732
 Pro Val Met Gly Val Val Val Gln Val Arg Ile Pro Ser Arg Val Asp
                 210                 215                 220

 aag tcc gag tcc agt cct ccg aag caa ttt gac caa gag aac ctg ctg      780
 Lys Ser Glu Ser Ser Pro Pro Lys Gln Phe Asp Gln Glu Asn Leu Leu
             225                 230                 235

 cca gcc cca gtg gtt ctt gct agc gtc cac gag ctg gac ctg ttc agg      828
 Pro Ala Pro Val Val Leu Ala Ser Val His Glu Leu Asp Leu Phe Arg
         240                 245                 250

 tgc ttc cgg cct gtg ttg act cat atg cag aca ctg tgg gag ctc atg      876
 Cys Phe Arg Pro Val Leu Thr His Met Gln Thr Leu Trp Glu Leu Met
     255                 260                 265

 ctc ctc ggg gag ccc ctg cta gtc ctg gca ccc tcg ccc gac gtg tcc      924
 Leu Leu Gly Glu Pro Leu Leu Val Leu Ala Pro Ser Pro Asp Val Ser
 270                 275                 280                 285

 tcg gag atg gtg ctg gcc ttg acc agc tgc ctg cag ccc ctc agg ttc      972
 Ser Glu Met Val Leu Ala Leu Thr Ser Cys Leu Gln Pro Leu Arg Phe
                 290                 295                 300

 tgc tgc gac ttc cgt ccc tac ttc acc atc cat gac agc gag ttc aag     1020
 Cys Cys Asp Phe Arg Pro Tyr Phe Thr Ile His Asp Ser Glu Phe Lys
             305                 310                 315

 gag ttc acc aca cgc acg cag gcc cca cca aac gtg gtc ctg gga gtc     1068
 Glu Phe Thr Thr Arg Thr Gln Ala Pro Pro Asn Val Val Leu Gly Val
         320                 325                 330

 aca aac cct ttc ttt atc aaa aca ctc cag cac tgg ccc cac atc ctc     1116
 Thr Asn Pro Phe Phe Ile Lys Thr Leu Gln His Trp Pro His Ile Leu
     335                 340                 345

 cga gtc ggg gag ccc aag atg tca gga gac ctg cct aag caa gtc aag     1164
 Arg Val Gly Glu Pro Lys Met Ser Gly Asp Leu Pro Lys Gln Val Lys
 350                 355                 360                 365

 ctg aaa aag cct tca agg ttg aag acc ctg gac acc aag cca ggc ctc     1212
 Leu Lys Lys Pro Ser Arg Leu Lys Thr Leu Asp Thr Lys Pro Gly Leu
                 370                 375                 380

 tac acc gct tac acg gcc cac ctc cac cgc gac aag gcg ctg ctc aaa     1260
 Tyr Thr Ala Tyr Thr Ala His Leu His Arg Asp Lys Ala Leu Leu Lys
             385                 390                 395

 cgg ctg ctc aag ggc gtg cag aag aag cgg ccg tca gat gtg cag agc     1308
 Arg Leu Leu Lys Gly Val Gln Lys Lys Arg Pro Ser Asp Val Gln Ser
         400                 405                 410

 gcc ctg ctg cgg cgg cac ctc ctg gag ctc acc cag agc ttc atc atc     1356
 Ala Leu Leu Arg Arg His Leu Leu Glu Leu Thr Gln Ser Phe Ile Ile
     415                 420                 425

 ccc ctg gag cac tac atg gcc agc ctc atg ccc ctg cag aag agc atc     1404
 Pro Leu Glu His Tyr Met Ala Ser Leu Met Pro Leu Gln Lys Ser Ile
 430                 435                 440                 445

 acg ccc tgg aag act ccc ccc cag atc cag ccc ttc agc cag gat gac     1452
 Thr Pro Trp Lys Thr Pro Pro Gln Ile Gln Pro Phe Ser Gln Asp Asp
                 450                 455                 460

 ttc ctg cgt agc ctg gag cat gct ggg ccc cag ctc acc tgc atc ctc     1500
 Phe Leu Arg Ser Leu Glu His Ala Gly Pro Gln Leu Thr Cys Ile Leu
             465                 470                 475

 aag ggc gac tgg ctg ggt ctc tac agg cgg ttt ttc aag tcc ccc cat     1548
 Lys Gly Asp Trp Leu Gly Leu Tyr Arg Arg Phe Phe Lys Ser Pro His
         480                 485                 490

 ttt gat ggc tgg tac cgg cag cgg cac aag gag atg gcc ctg aag ctg     1596
 Phe Asp Gly Trp Tyr Arg Gln Arg His Lys Glu Met Ala Leu Lys Leu
     495                 500                 505

 gag gcc ctg cac ctg gag gct atc tgt gag gcg aac atc gag acc tgg     1644
 Glu Ala Leu His Leu Glu Ala Ile Cys Glu Ala Asn Ile Glu Thr Trp
 510                 515                 520                 525

 atg aaa gac aag tcc gag gtg gag gtc gtg gac ctg gtc ctg aaa ctt     1692
 Met Lys Asp Lys Ser Glu Val Glu Val Val Asp Leu Val Leu Lys Leu
                 530                 535                 540

 cgt gag aag ctg gtg cgg gct cag ggc cac cag ctc cct gtg aag gag     1740
 Arg Glu Lys Leu Val Arg Ala Gln Gly His Gln Leu Pro Val Lys Glu
             545                 550                 555

 gct acg ctg cag cgg gca cag ctg tac atc gag acg gtc atc ggc tcc     1788
 Ala Thr Leu Gln Arg Ala Gln Leu Tyr Ile Glu Thr Val Ile Gly Ser
         560                 565                 570

 ctg ccc aaa gac ctg cag gct gtc ttg tgc cct ccc tag aacaaagcca      1837
 Leu Pro Lys Asp Leu Gln Ala Val Leu Cys Pro Pro 
     575                 580                 585

 agggccacgg tcccagggcc ctaggtctgc ctgagcctcc cactccccag tggtggcggc   1897

 actgggccaa gcacacgctc cccttccttg gccccccgcc cagactgcag gctccccttc   1957

 ctgcaccacc attgtctcag cagtaaaggc gacatttgga accacaaaaa aaaaaaaaaa   2017

 aagggggg                                                            2025




      <210> 17
      <211> 695
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (60)..(695)

      <400> 17
 aaggatcctt aattaaatta atcccccccc cccccccagc gcttgtgcaa accgggaag      59                                                                 
 atg gcg gcc ggc ggc ggc gga ggc agc agt aag gcc tcc tcc tcg tcg      107
 Met Ala Ala Gly Gly Gly Gly Gly Ser Ser Lys Ala Ser Ser Ser Ser
   1               5                  10                  15

 gcc tct tcg gca ggg gct ctg gag tcc tcg ttg gat cga aaa ttc cag      155
 Ala Ser Ser Ala Gly Ala Leu Glu Ser Ser Leu Asp Arg Lys Phe Gln
              20                  25                  30

 tct gta acc aac acc atg gag tcc att caa ggc ttg tcg tct tgg tgt      203
 Ser Val Thr Asn Thr Met Glu Ser Ile Gln Gly Leu Ser Ser Trp Cys
          35                  40                  45

 ata gag aac aaa aaa cac cac agt act atc gtc tat cat tgg atg aag      251
 Ile Glu Asn Lys Lys His His Ser Thr Ile Val Tyr His Trp Met Lys
      50                  55                  60

 tgg ctc cgg aga tct gca tat ccc cac cgt ttg aat ctc ttt tac ctt      299
 Trp Leu Arg Arg Ser Ala Tyr Pro His Arg Leu Asn Leu Phe Tyr Leu
  65                  70                  75                  80

 gcc aat gat gtc ata cag aac tgt aaa agg aaa aat gca atc ata ttc      347
 Ala Asn Asp Val Ile Gln Asn Cys Lys Arg Lys Asn Ala Ile Ile Phe
                  85                  90                  95

 cgt gaa tca ttt gct gat gta ctt cct gaa gca gct gct cta gtg aag      395
 Arg Glu Ser Phe Ala Asp Val Leu Pro Glu Ala Ala Ala Leu Val Lys
             100                 105                 110

 gat cca tct gtc tct aag tct gta gaa cga atc ttt aaa atc tgg gaa      443
 Asp Pro Ser Val Ser Lys Ser Val Glu Arg Ile Phe Lys Ile Trp Glu
         115                 120                 125

 gat aga aat gta tac cca gaa gaa atg att gtg gca ttg aga gaa gct      491
 Asp Arg Asn Val Tyr Pro Glu Glu Met Ile Val Ala Leu Arg Glu Ala
     130                 135                 140

 ttg aca tct aca aat cca aaa gct gct ctc aag tct aag ata gtt gct      539
 Leu Thr Ser Thr Asn Pro Lys Ala Ala Leu Lys Ser Lys Ile Val Ala
 145                 150                 155                 160

 gaa ttt cga gcc cta att gaa gag ctg ttg cta tac aag cgc tca gaa      587
 Glu Phe Arg Ala Leu Ile Glu Glu Leu Leu Leu Tyr Lys Arg Ser Glu
                 165                 170                 175

 gat cag ata gaa ctg aag gaa aag cag ttg tca act atg agg gtg gat      635
 Asp Gln Ile Glu Leu Lys Glu Lys Gln Leu Ser Thr Met Arg Val Asp
             180                 185                 190

 gtg tgc agc aca gaa act ctc aaa tgc tta aaa ggt aat gct tac atc      683
 Val Cys Ser Thr Glu Thr Leu Lys Cys Leu Lys Gly Asn Ala Tyr Ile
         195                 200                 205

 ctt tta gag taa                                                      695
 Leu Leu Glu 
     210





      <210> 18
      <211> 1134
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (162)..(809)

      <400> 18
 tcctgaattc ccgggtcgac gatttcgagc tttctgtctg aggatttgcc tgttctgggc     60

 atttcaggaa aacgggatcg tacgctccgt ggtctttgtg ttgagatcta tccaggttgt    120

 ggcctgtgca gggtccccct tctttcctat ggctgaagaa t    atg gcc tca gtt     173
                                                  Met Ala Ser Val
                                                    1

 tcc tct tgg agc agg aaa atg gcg gct gcc agg ccc agc ctg ggc cga      221
 Ser Ser Trp Ser Arg Lys Met Ala Ala Ala Arg Pro Ser Leu Gly Arg
   5                  10                  15                  20

 gtc ctc cca gga tcc tct gtc ctg ttc ctg tgt gac atg cag gag aag      269
 Val Leu Pro Gly Ser Ser Val Leu Phe Leu Cys Asp Met Gln Glu Lys
                  25                  30                  35

 ttc cgc cac aac atc gcc tac ttc cca cag atc gtc tca gtg gct gcc      317
 Phe Arg His Asn Ile Ala Tyr Phe Pro Gln Ile Val Ser Val Ala Ala
              40                  45                  50

 cgc atg ctc aag gtg gcc cgg ctg ctt gag gtg cca gtc atg ctg acg      365
 Arg Met Leu Lys Val Ala Arg Leu Leu Glu Val Pro Val Met Leu Thr
          55                  60                  65

 gag cag tac cca caa ggc ctg ggc ccc acg gtg ccc gag ctg ggg act      413
 Glu Gln Tyr Pro Gln Gly Leu Gly Pro Thr Val Pro Glu Leu Gly Thr
      70                  75                  80

 gag ggc ctt cgg ccg ctg gcc aag acc tgc ttc agc atg gtg cct gcc      461
 Glu Gly Leu Arg Pro Leu Ala Lys Thr Cys Phe Ser Met Val Pro Ala
  85                  90                  95                 100

 ctg cag cag gag ctg gac agt cgg ccc cag ctg cgc tct gtg ctg ctc      509
 Leu Gln Gln Glu Leu Asp Ser Arg Pro Gln Leu Arg Ser Val Leu Leu
                 105                 110                 115

 tgt ggc att gag gca cag gcc tgc atc ttg aac acg acc ctg gac ctc      557
 Cys Gly Ile Glu Ala Gln Ala Cys Ile Leu Asn Thr Thr Leu Asp Leu
             120                 125                 130

 cta gac cgg ggg ctg cag gtc cat gtg gtg gtg gac gcc tgc tcc tca      605
 Leu Asp Arg Gly Leu Gln Val His Val Val Val Asp Ala Cys Ser Ser
         135                 140                 145

 cgc agc cag gtg gac cgg ctg gtg gct ctg gcc cgc atg aga cag agt      653
 Arg Ser Gln Val Asp Arg Leu Val Ala Leu Ala Arg Met Arg Gln Ser
     150                 155                 160

 ggt gcc ttc ctc tcc acc agc gaa ggg ctc att ctg cag ctt gtg ggc      701
 Gly Ala Phe Leu Ser Thr Ser Glu Gly Leu Ile Leu Gln Leu Val Gly
 165                 170                 175                 180

 gat gcc gtc cac ccc cag ttc aag gag atc cag aaa ctc atc aag gag      749
 Asp Ala Val His Pro Gln Phe Lys Glu Ile Gln Lys Leu Ile Lys Glu
                 185                 190                 195

 ccc gcc cca gac agc gga ctg ctg ggc ctc ttc caa ggc cag aac tcc      797
 Pro Ala Pro Asp Ser Gly Leu Leu Gly Leu Phe Gln Gly Gln Asn Ser
             200                 205                 210

 ctc ctc cac tga act ccaaccctgc cttgagggaa gaccaccctc ctgtcacccg      852
 Leu Leu His 
         215

 gacctcagtg gaagcccgtt ccccccatcc ctggatccca agagtggtgc gatccaccag    912

 gagtgccgcc ccttgtgggg gggggcaggg tgctgccttc ccattggaca gctgctcccg    972

 gaaatgcaaa tgagactcct ggaaactggg tgggaattgg ctgagccaag atggaggcgg   1032

 ggctcggccc gggccacttc acggggcgga aggggagggg cacgaagagt ctcagactgt   1092

 gggacacgga ctcgcagaat aaacatatat tgttggtgtt gc                      1134




      <210> 19
      <211> 1429
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (41)..(1429)

      <400> 19
 agcatcaccg cagaaacaaa ggctccagcc tccggacacc  atg tct gtg cgc ttt      55
                                              Met Ser Val Arg Phe
                                                1               5

 tct tct acc tcc agg aga ctt ggc tct tgc ggg ggc act ggc tct gtg      103
 Ser Ser Thr Ser Arg Arg Leu Gly Ser Cys Gly Gly Thr Gly Ser Val
                  10                  15                  20

 agg ctc tct agt ggg gga gca ggc ttt ggg gct gga aac aca tgc ggt      151
 Arg Leu Ser Ser Gly Gly Ala Gly Phe Gly Ala Gly Asn Thr Cys Gly
              25                  30                  35

 gtg cca ggc att gga agt ggc ttc tct tgt gct ttt ggg ggc acc tca      199
 Val Pro Gly Ile Gly Ser Gly Phe Ser Cys Ala Phe Gly Gly Thr Ser
          40                  45                  50

 tct gca gga ggc tat ggc gga ggt ctg ggc ggg gga agt gct tcc tgt      247
 Ser Ala Gly Gly Tyr Gly Gly Gly Leu Gly Gly Gly Ser Ala Ser Cys
      55                  60                  65

 gct gcc ttc aca ggg aat gag cac ggc ctc ctc tct ggc aat gag aag      295
 Ala Ala Phe Thr Gly Asn Glu His Gly Leu Leu Ser Gly Asn Glu Lys
  70                  75                  80                  85

 gtg acc atg cag aac ctc aac gac cgc ttg gcc tcc tac ctg gag aat      343
 Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr Leu Glu Asn
                  90                  95                 100

 gtt cga gcc cta gag gag gcc aac gct gac ttg gag cag aag atc aag      391
 Val Arg Ala Leu Glu Glu Ala Asn Ala Asp Leu Glu Gln Lys Ile Lys
             105                 110                 115

 ggg tgg tat gag aaa ttt gga cct ggt tct tgc cgt ggc ctt gat cat      439
 Gly Trp Tyr Glu Lys Phe Gly Pro Gly Ser Cys Arg Gly Leu Asp His
         120                 125                 130

 gat tac agc aga tat ttc cca att att gac aaa ctt aag aac cag ata      487
 Asp Tyr Ser Arg Tyr Phe Pro Ile Ile Asp Lys Leu Lys Asn Gln Ile
     135                 140                 145

 att tct gca act acc agt aat gcc cat gtt gtc ctg caa aat gat aat      535
 Ile Ser Ala Thr Thr Ser Asn Ala His Val Val Leu Gln Asn Asp Asn
 150                 155                 160                 165

 gca aga cta aca gct gat gac ttc aga cta aag ttt gaa aac gag cta      583
 Ala Arg Leu Thr Ala Asp Asp Phe Arg Leu Lys Phe Glu Asn Glu Leu
                 170                 175                 180

 gcg ctt cac cag agc gtg gag gcg gac atc aat ggt ttg cga aga gtc      631
 Ala Leu His Gln Ser Val Glu Ala Asp Ile Asn Gly Leu Arg Arg Val
             185                 190                 195

 ctg gat gag ctg acc ttg tgc aga acg gac ctg gag atc cag ctg gaa      679
 Leu Asp Glu Leu Thr Leu Cys Arg Thr Asp Leu Glu Ile Gln Leu Glu
         200                 205                 210

 act ctc agt gag gag ctc gct tac ctc aag aag aat cat gag gag gaa      727
 Thr Leu Ser Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu Glu Glu
     215                 220                 225

 atg aaa gct ctt cag tgc gcg gct gga ggc aac gtg aac gtg gag atg      775
 Met Lys Ala Leu Gln Cys Ala Ala Gly Gly Asn Val Asn Val Glu Met
 230                 235                 240                 245

 aac gcg gcc ccc ggg gta gac ctc acg gtt ctg ctg aac aat atg cga      823
 Asn Ala Ala Pro Gly Val Asp Leu Thr Val Leu Leu Asn Asn Met Arg
                 250                 255                 260

 gct gag tac gaa gcc ctc gca gag cag aac cgc agg gac gcg gag gcc      871
 Ala Glu Tyr Glu Ala Leu Ala Glu Gln Asn Arg Arg Asp Ala Glu Ala
             265                 270                 275

 tgg ttc aac gaa aag agc gcc tcg ctg cag cag cag atc tct gac gac      919
 Trp Phe Asn Glu Lys Ser Ala Ser Leu Gln Gln Gln Ile Ser Asp Asp
         280                 285                 290

 gct ggc gcc acc acc tca gcc cgg aat gag ctt atc gag atg aaa cgc      967
 Ala Gly Ala Thr Thr Ser Ala Arg Asn Glu Leu Ile Glu Met Lys Arg
     295                 300                 305

 act ctt caa acc ctt gag att gaa ctt cag tcc ctc tta gca acg aaa     1015
 Thr Leu Gln Thr Leu Glu Ile Glu Leu Gln Ser Leu Leu Ala Thr Lys
 310                 315                 320                 325

 cac tcc ctg gag tgc tcc ttg aca gag acc gag agt aac tac tgt gca     1063
 His Ser Leu Glu Cys Ser Leu Thr Glu Thr Glu Ser Asn Tyr Cys Ala
                 330                 335                 340

 cag ctg gca cag atc cag gct cag atc ggg gcc ctg gag gag cag ctg     1111
 Gln Leu Ala Gln Ile Gln Ala Gln Ile Gly Ala Leu Glu Glu Gln Leu
             345                 350                 355

 cac cag gtc aga acc gag acc gag ggc cag aag ctc gag tat gag cag     1159
 His Gln Val Arg Thr Glu Thr Glu Gly Gln Lys Leu Glu Tyr Glu Gln
         360                 365                 370

 ctc ctt gac atc aag gtc cac ctg gaa aaa gaa att gag acc tac tgc     1207
 Leu Leu Asp Ile Lys Val His Leu Glu Lys Glu Ile Glu Thr Tyr Cys
     375                 380                 385

 ctc ctg ata gat gga gaa gat ggg tca gta ttg ccg cca ttg aga aaa     1255
 Leu Leu Ile Asp Gly Glu Asp Gly Ser Val Leu Pro Pro Leu Arg Lys
 390                 395                 400                 405

 caa ttc att ttt aag ttt ata tgt ggc att tta gat tca tct aaa acc     1303
 Gln Phe Ile Phe Lys Phe Ile Cys Gly Ile Leu Asp Ser Ser Lys Thr
                 410                 415                 420

 acc att gtc aaa aca gtt gtt gaa gag ata gat cct cgt ggc aaa gtt     1351
 Thr Ile Val Lys Thr Val Val Glu Glu Ile Asp Pro Arg Gly Lys Val
             425                 430                 435

 ctc tca tcc aga gtt cac act gtg gaa gag aaa tcc acc aaa gtc aac     1399
 Leu Ser Ser Arg Val His Thr Val Glu Glu Lys Ser Thr Lys Val Asn
         440                 445                 450

 aac aag aat gaa cag agg gtg tct tcc tga                             1429
 Asn Lys Asn Glu Gln Arg Val Ser Ser 
     455                 460





      <210> 20
      <211> 1985
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (12)..(1985)

      <400> 20
 atgactgctc t atg tca gac cag gcg gga tgg agg cgg cgg gac cgg ctc      50
              Met Ser Asp Gln Ala Gly Trp Arg Arg Arg Asp Arg Leu
                1               5                  10

 gcg ggt gcg ggt ccg ggt gaa gcg gga ggc agc cag agt cgg agc cgg       98
 Ala Gly Ala Gly Pro Gly Glu Ala Gly Gly Ser Gln Ser Arg Ser Arg
      15                  20                  25

 gcc cga gca cca ggc gca gac gcc aca gcc atg gcc atg atg gtg ttt      146
 Ala Arg Ala Pro Gly Ala Asp Ala Thr Ala Met Ala Met Met Val Phe
  30                  35                  40                  45

 ccg cgg gag gag aag ctg agc cag gat gag atc gtg ctg ggc acc aag      194
 Pro Arg Glu Glu Lys Leu Ser Gln Asp Glu Ile Val Leu Gly Thr Lys
                  50                  55                  60

 gct gtc atc cag gga ctg gag act ctg cgt ggg gag cat cgt gcc ctg      242
 Ala Val Ile Gln Gly Leu Glu Thr Leu Arg Gly Glu His Arg Ala Leu
              65                  70                  75

 ctg gct cct ctg gtt gca cct gag gcc ggc gaa gcc gag cct ggc tcg      290
 Leu Ala Pro Leu Val Ala Pro Glu Ala Gly Glu Ala Glu Pro Gly Ser
          80                  85                  90

 cag gag cgc tgc atc ctc ctg cgt cgc tcc ctg gaa gcc att gag ctt      338
 Gln Glu Arg Cys Ile Leu Leu Arg Arg Ser Leu Glu Ala Ile Glu Leu
      95                 100                 105

 ggg ctg ggg gag gcc cag gtg atc ttg gca ttg tcg agc cac ctg ggg      386
 Gly Leu Gly Glu Ala Gln Val Ile Leu Ala Leu Ser Ser His Leu Gly
 110                 115                 120                 125

 gct gta gaa tca gag aag cag aag ctg cgg gcg cag gtg cgg cgt ctg      434
 Ala Val Glu Ser Glu Lys Gln Lys Leu Arg Ala Gln Val Arg Arg Leu
                 130                 135                 140

 gtg cag gag aac cag tgg ctg cgt gag gag ctg gcg ggg aca cag cag      482
 Val Gln Glu Asn Gln Trp Leu Arg Glu Glu Leu Ala Gly Thr Gln Gln
             145                 150                 155

 aag ctg cag cgc agt gag cag gcc gtg gcc cag ctc gag gag gag aag      530
 Lys Leu Gln Arg Ser Glu Gln Ala Val Ala Gln Leu Glu Glu Glu Lys
         160                 165                 170

 cag cac ttg ctg ttc atg agc cag atc cgc aag ttg gat gaa gac gcc      578
 Gln His Leu Leu Phe Met Ser Gln Ile Arg Lys Leu Asp Glu Asp Ala
     175                 180                 185

 tcc cct aac gag gag aag ggg gac gtc ccc aaa gac aca ctg gat gac      626
 Ser Pro Asn Glu Glu Lys Gly Asp Val Pro Lys Asp Thr Leu Asp Asp
 190                 195                 200                 205

 ctg ttc ccc aat gag gat gag cag agc cca gga gga ggg gat gtg tct      674
 Leu Phe Pro Asn Glu Asp Glu Gln Ser Pro Gly Gly Gly Asp Val Ser
                 210                 215                 220

 ggt cag cat ggg ggc tac gag atc ccg gcc cgg ctc cgc acc ctg cac      722
 Gly Gln His Gly Gly Tyr Glu Ile Pro Ala Arg Leu Arg Thr Leu His
             225                 230                 235

 aac ctg gtg atc caa tac gcc tca cag ggc cgc tac gag gta gct gcg      770
 Asn Leu Val Ile Gln Tyr Ala Ser Gln Gly Arg Tyr Glu Val Ala Ala
         240                 245                 250

 cca ctc tgc aag cag gca ctc gaa gac ctg gag aag acg tca ggc cac      818
 Pro Leu Cys Lys Gln Ala Leu Glu Asp Leu Glu Lys Thr Ser Gly His
     255                 260                 265

 gac cac cct gac gtt gcc acc atg ctg aac atc ctg gca ctg gtc tat      866
 Asp His Pro Asp Val Ala Thr Met Leu Asn Ile Leu Ala Leu Val Tyr
 270                 275                 280                 285

 cgg gat cag aac aag tac aag gag gct gcc cac ctg ctc aat gat gct      914
 Arg Asp Gln Asn Lys Tyr Lys Glu Ala Ala His Leu Leu Asn Asp Ala
                 290                 295                 300

 ctg gcc atc cgg gag aaa aca ctg ggc aag gac cac cca gcc gtg gct      962
 Leu Ala Ile Arg Glu Lys Thr Leu Gly Lys Asp His Pro Ala Val Ala
             305                 310                 315

 gcg aca cta aac aac ctg gca gtc ctg tat ggc aag agg gga aag tac     1010
 Ala Thr Leu Asn Asn Leu Ala Val Leu Tyr Gly Lys Arg Gly Lys Tyr
         320                 325                 330

 aag gag gct gag cca ttg tgc aag cgg gca ctg gag atc cgg gag aag     1058
 Lys Glu Ala Glu Pro Leu Cys Lys Arg Ala Leu Glu Ile Arg Glu Lys
     335                 340                 345

 gtc ctg ggc aag ttt cac cca gat gtg gcc aag cag ctc agc aac ctg     1106
 Val Leu Gly Lys Phe His Pro Asp Val Ala Lys Gln Leu Ser Asn Leu
 350                 355                 360                 365

 gcc ctg ctg tgc cag aac cag ggc aaa gct gag gag gtg gaa tat tac     1154
 Ala Leu Leu Cys Gln Asn Gln Gly Lys Ala Glu Glu Val Glu Tyr Tyr
                 370                 375                 380

 tat cgg cgg gca ctg gag atc tat gct aca cgc ctc ggg ccc gat gat     1202
 Tyr Arg Arg Ala Leu Glu Ile Tyr Ala Thr Arg Leu Gly Pro Asp Asp
             385                 390                 395

 ccc aat gtg gcc aag acc aag aac aac ctg gct tcc tgc tac ctg aag     1250
 Pro Asn Val Ala Lys Thr Lys Asn Asn Leu Ala Ser Cys Tyr Leu Lys
         400                 405                 410

 cag ggc aag tac cag gat gcg gag acc ttg tac aag gag atc ctc acc     1298
 Gln Gly Lys Tyr Gln Asp Ala Glu Thr Leu Tyr Lys Glu Ile Leu Thr
     415                 420                 425

 cgc gct cat gag aaa gag ttt ggc tct gtc aat ggg gac aac aag ccc     1346
 Arg Ala His Glu Lys Glu Phe Gly Ser Val Asn Gly Asp Asn Lys Pro
 430                 435                 440                 445

 atc tgg atg cac gca gag gag cgg gag gaa agc aag gat aag cgc cgg     1394
 Ile Trp Met His Ala Glu Glu Arg Glu Glu Ser Lys Asp Lys Arg Arg
                 450                 455                 460

 gac agc gcc ccc tat ggg gaa tac ggc agc tgg tac aag gcc tgt aaa     1442
 Asp Ser Ala Pro Tyr Gly Glu Tyr Gly Ser Trp Tyr Lys Ala Cys Lys
             465                 470                 475

 gta gac agc ccc aca gtc aac acc acc ctg cgc agc ttg ggg gcc cta     1490
 Val Asp Ser Pro Thr Val Asn Thr Thr Leu Arg Ser Leu Gly Ala Leu
         480                 485                 490

 tac cgg cgc cag ggc aag ctg gaa gcc gcg cac aca cta gag gac tgt     1538
 Tyr Arg Arg Gln Gly Lys Leu Glu Ala Ala His Thr Leu Glu Asp Cys
     495                 500                 505

 gcc agc cgt aac cgc aag cag ggt ttg gac ccc gca agc cag acc aag     1586
 Ala Ser Arg Asn Arg Lys Gln Gly Leu Asp Pro Ala Ser Gln Thr Lys
 510                 515                 520                 525

 gtg gta gaa ctg ctg aaa gat ggc agt ggc agg cgg gga gac cgc cgc     1634
 Val Val Glu Leu Leu Lys Asp Gly Ser Gly Arg Arg Gly Asp Arg Arg
                 530                 535                 540

 agc agc cga gac atg gct ggg ggt gcc ggg cct cgg tct gag tct gac     1682
 Ser Ser Arg Asp Met Ala Gly Gly Ala Gly Pro Arg Ser Glu Ser Asp
             545                 550                 555

 ctc gag gac gtg gga cct aca gct gag tgg aat ggg gat ggc agt ggc     1730
 Leu Glu Asp Val Gly Pro Thr Ala Glu Trp Asn Gly Asp Gly Ser Gly
         560                 565                 570

 tcc ttg agg cgc agc ggt tcc ttt ggg aaa ctc cgg gat gcc ctg agg     1778
 Ser Leu Arg Arg Ser Gly Ser Phe Gly Lys Leu Arg Asp Ala Leu Arg
     575                 580                 585

 cgc agc agt gag atg ctg gta aag aag ctg cag ggg ggc acc ccc cag     1826
 Arg Ser Ser Glu Met Leu Val Lys Lys Leu Gln Gly Gly Thr Pro Gln
 590                 595                 600                 605

 gag ccc cct aac ccc agg atg aag cgg gcc agt tcc ctc aac ttc ctc     1874
 Glu Pro Pro Asn Pro Arg Met Lys Arg Ala Ser Ser Leu Asn Phe Leu
                 610                 615                 620

 aac aag agc gtg gaa gag ccg acc cag cct gga ggc aca ggt ctc tct     1922
 Asn Lys Ser Val Glu Glu Pro Thr Gln Pro Gly Gly Thr Gly Leu Ser
             625                 630                 635

 gac agc cgc act ctc agc tcc agc tcc atg gac ctc tcc cga cga agc     1970
 Asp Ser Arg Thr Leu Ser Ser Ser Ser Met Asp Leu Ser Arg Arg Ser
         640                 645                 650

 tcc ctg gtg ggc taa                                                 1985
 Ser Leu Val Gly 
     655





      <210> 21
      <211> 816
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(816)

      <400> 21
  atg gcg ccc agc cgg aat ggc atg gtc ttg aag ccc cac ttc cac aag      48
  Met Ala Pro Ser Arg Asn Gly Met Val Leu Lys Pro His Phe His Lys
    1               5                  10                  15

 gac tgg cag cgg cgc gtg gcc acg tgg ttc aac cag ccg gcc cgt aag       96
 Asp Trp Gln Arg Arg Val Ala Thr Trp Phe Asn Gln Pro Ala Arg Lys
              20                  25                  30

 atc cgc aga cgt aag gcc cgg caa gcc aag gcg cgc cgc atc gcc ccg      144
 Ile Arg Arg Arg Lys Ala Arg Gln Ala Lys Ala Arg Arg Ile Ala Pro
          35                  40                  45

 cgc ccc gcg tcg ggt ccc atc cgg ccc atc gtg cgc tgc ccc acg gtt      192
 Arg Pro Ala Ser Gly Pro Ile Arg Pro Ile Val Arg Cys Pro Thr Val
      50                  55                  60

 cgg tac cac acg aag gtg cgc gcc ggc cgc ggc ttc agc ctg gag gag      240
 Arg Tyr His Thr Lys Val Arg Ala Gly Arg Gly Phe Ser Leu Glu Glu
  65                  70                  75                  80

 ctc agg gtg gcc ggc att cac aag aag gtg gcc cgg acc atc ggc att      288
 Leu Arg Val Ala Gly Ile His Lys Lys Val Ala Arg Thr Ile Gly Ile
                  85                  90                  95

 tct gtg gat ccg agg agg cgg aac aag tcc acg gag tcc ctg cag gcc      336
 Ser Val Asp Pro Arg Arg Arg Asn Lys Ser Thr Glu Ser Leu Gln Ala
             100                 105                 110

 aac gtg cag cgg ctg aag gag tac cgc tcc aaa ctc atc ctc ttc ccc      384
 Asn Val Gln Arg Leu Lys Glu Tyr Arg Ser Lys Leu Ile Leu Phe Pro
         115                 120                 125

 agg aag ccc tcg gcc ccc aag aag gga gac agt tct gct gaa gaa ctg      432
 Arg Lys Pro Ser Ala Pro Lys Lys Gly Asp Ser Ser Ala Glu Glu Leu
     130                 135                 140

 aaa ctg gcc acc cag ctg acc gga ccg gtc atg ccc gtc cgg aac gtc      480
 Lys Leu Ala Thr Gln Leu Thr Gly Pro Val Met Pro Val Arg Asn Val
 145                 150                 155                 160

 tat aag aag gag aaa gct cga gtc atc act gag gaa gag aag aat ttc      528
 Tyr Lys Lys Glu Lys Ala Arg Val Ile Thr Glu Glu Glu Lys Asn Phe
                 165                 170                 175

 aaa gcc ttc gct agt ctc cgt atg gcc cgt gcc aac gcc cgg ctc ttc      576
 Lys Ala Phe Ala Ser Leu Arg Met Ala Arg Ala Asn Ala Arg Leu Phe
             180                 185                 190

 ggc ata cgg gca aaa aga gcc aag gaa gcc gca gaa cag gat gtt gaa      624
 Gly Ile Arg Ala Lys Arg Ala Lys Glu Ala Ala Glu Gln Asp Val Glu
         195                 200                 205

 aag aaa aaa aaa agc cct cct ggg gac ttg gaa tcc agt cgg cag tca      672
 Lys Lys Lys Lys Ser Pro Pro Gly Asp Leu Glu Ser Ser Arg Gln Ser
     210                 215                 220

 tgc tgg gtc tcc acg tgg tgt gtt tcg tgg gaa caa ctg ggc ctg gga      720
 Cys Trp Val Ser Thr Trp Cys Val Ser Trp Glu Gln Leu Gly Leu Gly
 225                 230                 235                 240

 tgg ggc ttc act gct gtg act tcc tcc tgc cag ggg att tgg ggc ttt      768
 Trp Gly Phe Thr Ala Val Thr Ser Ser Cys Gln Gly Ile Trp Gly Phe
                 245                 250                 255

 ctt gaa aga cag tcc aag ccc tgg ata atg ctt tac ttt ctg tgt tga      816
 Leu Glu Arg Gln Ser Lys Pro Trp Ile Met Leu Tyr Phe Leu Cys 
             260                 265                 270





      <210> 22
      <211> 2252
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (346)..(2007)

      <400> 22
 cggacgcgtg ggtggcaatt gtccaagaaa agatttcagg tttgtcaagt tttggtatag     60

 aactcggttt ctttgttgaa gaatatgctg gaagcaaagg aagatttcct ccaactaaaa    120

 gaagggaaaa gaaatcactc tatattgcca ctattgaaaa aggacatagc ttggtgaact    180

 ccttgattga aactggaaga attgacagtc tgggtctggt tgttgtagac gagttgcaca    240

 tgattggtga aggaagccgt ggagctacac tggaaatgac cctagcaaaa atcctctaca    300

 ctagcaaaac gactcaaatt atcggtatga gtgcaacatt aaaca    atg ttg aag     354
                                                      Met Leu Lys
                                                        1

 acc tac aaa agt ttc ttc aag cag aat att ata cca gtc aat tta gac      402
 Thr Tyr Lys Ser Phe Phe Lys Gln Asn Ile Ile Pro Val Asn Leu Asp
       5                  10                  15

 cag tat gta cct aag gtt gag tta aaa gaa tat ctg aaa ata aat gat      450
 Gln Tyr Val Pro Lys Val Glu Leu Lys Glu Tyr Leu Lys Ile Asn Asp
  20                  25                  30                  35

 aca ata tat gaa gtt gac agc aaa gct gag aat ggc atg act ttt tca      498
 Thr Ile Tyr Glu Val Asp Ser Lys Ala Glu Asn Gly Met Thr Phe Ser
                  40                  45                  50

 cgt ctt ctt aat tat aag tat tct gat acc cta aaa aag atg gat cct      546
 Arg Leu Leu Asn Tyr Lys Tyr Ser Asp Thr Leu Lys Lys Met Asp Pro
              55                  60                  65

 gat cac ttg gta gca ttg gtg aca gaa gtt att ccc aat tat tcc tgc      594
 Asp His Leu Val Ala Leu Val Thr Glu Val Ile Pro Asn Tyr Ser Cys
          70                  75                  80

 tta gtt ttt tgt cct agt aag aag aac tgt gaa aat gta gca gaa atg      642
 Leu Val Phe Cys Pro Ser Lys Lys Asn Cys Glu Asn Val Ala Glu Met
      85                  90                  95

 ata tgc aaa ttt tta agc aag gaa tat ctg aaa cat aag gag aaa gaa      690
 Ile Cys Lys Phe Leu Ser Lys Glu Tyr Leu Lys His Lys Glu Lys Glu
 100                 105                 110                 115

 aaa tgt gag gtg att aag aac ttg aag aat att ggc aat ggc aac ctg      738
 Lys Cys Glu Val Ile Lys Asn Leu Lys Asn Ile Gly Asn Gly Asn Leu
                 120                 125                 130

 tgt cct gtt tta aag cgc act atc cca ttt gga gtt gcc tat cac cac      786
 Cys Pro Val Leu Lys Arg Thr Ile Pro Phe Gly Val Ala Tyr His His
             135                 140                 145

 agt ggc tta aca agt gat gaa agg aaa ctc ttg gag gag gcc tac tcc      834
 Ser Gly Leu Thr Ser Asp Glu Arg Lys Leu Leu Glu Glu Ala Tyr Ser
         150                 155                 160

 aca gga gtg ctc tgt ctt ttt acc tgc aca tct acc cta gcg gca ggt      882
 Thr Gly Val Leu Cys Leu Phe Thr Cys Thr Ser Thr Leu Ala Ala Gly
     165                 170                 175

 gtc aac cta cca gct cga aga gtt att tta aga gct ccc tat gtt gct      930
 Val Asn Leu Pro Ala Arg Arg Val Ile Leu Arg Ala Pro Tyr Val Ala
 180                 185                 190                 195

 aag gaa ttt tta aag agg aat caa tat aaa cag atg att ggc aga gct      978
 Lys Glu Phe Leu Lys Arg Asn Gln Tyr Lys Gln Met Ile Gly Arg Ala
                 200                 205                 210

 ggt cgt gct gga ata gat act att ggg gag agt atc ctc ata ttg caa     1026
 Gly Arg Ala Gly Ile Asp Thr Ile Gly Glu Ser Ile Leu Ile Leu Gln
             215                 220                 225

 gaa aaa gac aaa caa cag gta ttg gag tta ata act aaa cca ttg gaa     1074
 Glu Lys Asp Lys Gln Gln Val Leu Glu Leu Ile Thr Lys Pro Leu Glu
         230                 235                 240

 aac tgt tac agc cat ctt gtt cag gaa ttc acc aag gga atc caa aca     1122
 Asn Cys Tyr Ser His Leu Val Gln Glu Phe Thr Lys Gly Ile Gln Thr
     245                 250                 255

 tta ttt ctc tct ttg att ggt ttg aag att gca acg aat ctt gat gac     1170
 Leu Phe Leu Ser Leu Ile Gly Leu Lys Ile Ala Thr Asn Leu Asp Asp
 260                 265                 270                 275

 atc tat cat ttc atg aat ggt aca ttt ttt ggt gtt cag caa aag gtt     1218
 Ile Tyr His Phe Met Asn Gly Thr Phe Phe Gly Val Gln Gln Lys Val
                 280                 285                 290

 tta ttg aaa gaa aaa agt ctc tgg gaa ata act gtt gaa tca ctt aga     1266
 Leu Leu Lys Glu Lys Ser Leu Trp Glu Ile Thr Val Glu Ser Leu Arg
             295                 300                 305

 tac ctg aca gaa aaa gga ctc cta caa aaa gac act att tat aag tct     1314
 Tyr Leu Thr Glu Lys Gly Leu Leu Gln Lys Asp Thr Ile Tyr Lys Ser
         310                 315                 320

 gaa gaa gag gtc caa tat aat ttt cat att aca aag ttg gga cgt gct     1362
 Glu Glu Glu Val Gln Tyr Asn Phe His Ile Thr Lys Leu Gly Arg Ala
     325                 330                 335

 tca ttt aag gga act ata gat tta gct tat tgt gac att ctg tac aga     1410
 Ser Phe Lys Gly Thr Ile Asp Leu Ala Tyr Cys Asp Ile Leu Tyr Arg
 340                 345                 350                 355

 gac ttg aag aaa ggt ctt gaa gga ctt gtg ctt gaa agc ctt ctt cat     1458
 Asp Leu Lys Lys Gly Leu Glu Gly Leu Val Leu Glu Ser Leu Leu His
                 360                 365                 370

 cta atc tac cta aca acc ccc tat gat ctg gtt tca cag tgt aac cct     1506
 Leu Ile Tyr Leu Thr Thr Pro Tyr Asp Leu Val Ser Gln Cys Asn Pro
             375                 380                 385

 gat tgg atg ata tac ttc agg cag ttt agc caa ctc agt cca gca gaa     1554
 Asp Trp Met Ile Tyr Phe Arg Gln Phe Ser Gln Leu Ser Pro Ala Glu
         390                 395                 400

 caa aat gta gct gcc att ctt gga gtc tct gaa agc ttt att ggg aag     1602
 Gln Asn Val Ala Ala Ile Leu Gly Val Ser Glu Ser Phe Ile Gly Lys
     405                 410                 415

 aaa gca tca ggc caa gcc atc gga aag aag gtg gac aag aac gtt gtc     1650
 Lys Ala Ser Gly Gln Ala Ile Gly Lys Lys Val Asp Lys Asn Val Val
 420                 425                 430                 435

 aac agg cta tat ctg tct ttt gtt ctt tat acc ttg ctc aaa gag acc     1698
 Asn Arg Leu Tyr Leu Ser Phe Val Leu Tyr Thr Leu Leu Lys Glu Thr
                 440                 445                 450

 aac att tgg act gta tct gaa aaa ttt aat atg cct cga gga tat ata     1746
 Asn Ile Trp Thr Val Ser Glu Lys Phe Asn Met Pro Arg Gly Tyr Ile
             455                 460                 465

 caa aat ctt ctc act gga act gcc tca ttc tca tct tgt gtg tta cat     1794
 Gln Asn Leu Leu Thr Gly Thr Ala Ser Phe Ser Ser Cys Val Leu His
         470                 475                 480

 ttc tgt gag gag ctt gag gag ttt tgg gtt tac aga gcc ctt ttg gta     1842
 Phe Cys Glu Glu Leu Glu Glu Phe Trp Val Tyr Arg Ala Leu Leu Val
     485                 490                 495

 gaa ctt acc aag aag ctg act tac tgt gta aag gca gaa tta atc cct     1890
 Glu Leu Thr Lys Lys Leu Thr Tyr Cys Val Lys Ala Glu Leu Ile Pro
 500                 505                 510                 515

 ctc atg gaa gtt act gga gtt tta gag ggt cga gca aaa cag tta tac     1938
 Leu Met Glu Val Thr Gly Val Leu Glu Gly Arg Ala Lys Gln Leu Tyr
                 520                 525                 530

 agt gca ggt tac aaa agt cta atg cac tta gct aat gca aat cct gca     1986
 Ser Ala Gly Tyr Lys Ser Leu Met His Leu Ala Asn Ala Asn Pro Ala
             535                 540                 545

 agt gct cgt aag gac aat tga tc atttatcaag acgccaagcc aagcaaattg     2039
 Ser Ala Arg Lys Asp Asn 
         550

 tttcatcagc aaagatgctg ttgcatgaac acagcccatg gccctgcaga agaggtagaa   2099

 gagttactaa gattgccttc tgatttccct ggtgctgtgg cttcttccac tgacaaagca   2159

 tgaagctatc tgatgagaat tttcatatat gaattattta ttgtacatgt gtgttattaa   2219

 agataactta tactttaaaa aaaaaaaaaa aaa                                2252




      <210> 23
      <211> 738
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (88)..(666)

      <400> 23
 aaggatcctt aattaaatta atcccccccc ccccccccga cgccatgttt cctctttcgg     60

 ccgcgctggt gaacaggacc cgtcgcc    atg ggc cgt gtg atc cgt gga cag     111
                                  Met Gly Arg Val Ile Arg Gly Gln
                                    1               5

 agg aag ggc gcc ggg tct gtg ttc cgc gcg cac gtg aag cac cgt aaa      159
 Arg Lys Gly Ala Gly Ser Val Phe Arg Ala His Val Lys His Arg Lys
      10                  15                  20

 ggc gct gcg cgc ctg cgc gcc gtg gat ttc gct gag cgg cac ggc tac      207
 Gly Ala Ala Arg Leu Arg Ala Val Asp Phe Ala Glu Arg His Gly Tyr
  25                  30                  35                  40

 atc aag ggc atc gtc aag gac atc atc cac gac ccg ggc cgc ggc gcg      255
 Ile Lys Gly Ile Val Lys Asp Ile Ile His Asp Pro Gly Arg Gly Ala
                  45                  50                  55

 ccc ctc gcc aag gtg gtc ttc cgg gat ccg tat cgg ttt aag aag cgg      303
 Pro Leu Ala Lys Val Val Phe Arg Asp Pro Tyr Arg Phe Lys Lys Arg
              60                  65                  70

 acg gag ctg ttc att gcc gcc gag ggc att cac acg ggc cag ttt gtg      351
 Thr Glu Leu Phe Ile Ala Ala Glu Gly Ile His Thr Gly Gln Phe Val
          75                  80                  85

 tat tgc ggc aag aag gcc cag ctc aac att ggc aat gtg ctc cct gtg      399
 Tyr Cys Gly Lys Lys Ala Gln Leu Asn Ile Gly Asn Val Leu Pro Val
      90                  95                 100

 ggc acc atg cct gag ggt aca atc gtg tgc tgc ctg gag gag aag cct      447
 Gly Thr Met Pro Glu Gly Thr Ile Val Cys Cys Leu Glu Glu Lys Pro
 105                 110                 115                 120

 gga gac cgt ggc aag ctg gcc cgg gca tca ggg aac tat gcc acc gtt      495
 Gly Asp Arg Gly Lys Leu Ala Arg Ala Ser Gly Asn Tyr Ala Thr Val
                 125                 130                 135

 atc tcc cac aat cct gtg gag cat cct ttt gga ggt ggc aac cac cag      543
 Ile Ser His Asn Pro Val Glu His Pro Phe Gly Gly Gly Asn His Gln
             140                 145                 150

 cac atc ggc aag ccc tcc acc atc cgc aga gat gcc cct gct ggc cgc      591
 His Ile Gly Lys Pro Ser Thr Ile Arg Arg Asp Ala Pro Ala Gly Arg
         155                 160                 165

 aaa gtg ggt ctc att gct gcc cgc cgg act gga cgt ctc cgg gga acc      639
 Lys Val Gly Leu Ile Ala Ala Arg Arg Thr Gly Arg Leu Arg Gly Thr
     170                 175                 180

 aag act gtg cag gag aaa gag aac tag tgctg agggcctcaa taaagtttgt      691
 Lys Thr Val Gln Glu Lys Glu Asn 
 185                 190

 gtttatgcca aaaaaaaaaa aaaaaaaggt ttgcggccgc aagctta                  738




      <210> 24
      <211> 880
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(360)

      <400> 24
 ggc  atg acg agc cgg tcc gga agg aag agg cag gcg gcc cta gag gtc      48
      Met Thr Ser Arg Ser Gly Arg Lys Arg Gln Ala Ala Leu Glu Val
        1               5                  10                  15

 acc gct cgc tac tgt ggc cgg gag ctg gag cag tat ggc cag tgt gtg       96
 Thr Ala Arg Tyr Cys Gly Arg Glu Leu Glu Gln Tyr Gly Gln Cys Val
                  20                  25                  30

 gcg gcc aag ccg gaa tcc tgg cag cgg gac tgt cac tac ctt aag atg      144
 Ala Ala Lys Pro Glu Ser Trp Gln Arg Asp Cys His Tyr Leu Lys Met
              35                  40                  45

 agc att gcc cag tgc aca tcc tcc cac cca atc atc cgc cag atc cgc      192
 Ser Ile Ala Gln Cys Thr Ser Ser His Pro Ile Ile Arg Gln Ile Arg
          50                  55                  60

 cag gcc tgt gct cag cct ttt gag gcc ttc gag gag tgt ctt cga cag      240
 Gln Ala Cys Ala Gln Pro Phe Glu Ala Phe Glu Glu Cys Leu Arg Gln
      65                  70                  75

 aac gag gca gct gtg ggc aac tgt gca gag cat atg cgc cgc ttc ctg      288
 Asn Glu Ala Ala Val Gly Asn Cys Ala Glu His Met Arg Arg Phe Leu
  80                  85                  90                  95

 cag tgc gct gag cag gtg cag ccg cca cgc tca cct gca act gtg gag      336
 Gln Cys Ala Glu Gln Val Gln Pro Pro Arg Ser Pro Ala Thr Val Glu
                 100                 105                 110

 gca cag cca ctt cct gcc tcc tga ggactcctct gacggcagga aaactggaca     390
 Ala Gln Pro Leu Pro Ala Ser 
             115

 tgaatgactg cccccccgcc cctcccctgc agagtggcca gatggagtcc tgagccctgg    450

 acatgggccc ggctttcctg gatatcagga cttccaataa ataaagactc tgtatactgg    510

 gaaaaaaaga caactcacgc ccaaaacctg gggggcctca atgtccgggc ggggaacaca    570

 ggggtttctc caatggccca cttggcctaa cctttcccgt gccccagttc tgtgacaaac    630

 gtgggtgtta aaactctggc gcgggtcccc cattataaga gaggccccga tatataaaat    690

 ttgcgagaaa agcccaggtt accgttccac tacgtctccg aatcagtagc gttgcgctat    750

 agctcacatc gtcacatacc tgcagcccga acatgacaca attagtcgta ctcctacgta    810

 cctccgctca gccgtcgcca catctctctc cgcgctctac aagcggcgct ctcactcctg    870

 ctcacacctg                                                           880




      <210> 25
      <211> 3278
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (863)..(1642)

      <400> 25
 gagaaagaga gacagagaga gtgaccaaga cagaccacac acccaggtct cggatggtaa     60

 ggggctgaag cggctgctct tctgcctttc tgctgctcgt ggttcagtct gttcagattg    120

 tttcctgttg ttaattgcgg ccccattcca tgtctcagtc caaactgcga gagcaacatg    180

 tcattgcctg ggccttccag ccaggcaggc cacacaggtc agaagtggct ggctagcctg    240

 gggatgacca cccccttctc ggaccaagat gggccatggg aggggcagga attcctttga    300

 gaggagacct aggggtgtgg ggtctgggca ggtaaggtaa gtgataccta ctagttgcct    360

 tgttgctttt cccattttcc ccaacttttc agaaaaatgc tggcctttat agcgacatca    420

 ggatgatggt agctaatatt ctattgagtg tttgctgtgt gccaggcact gtgctgtgct    480

 cagcacgtgt tacaggcatt aactgtgttc ccaccttggc tcagagagga tttggtcact    540

 tgccagggtc ccatatctag ctaatgatgc caagcttcta ctccgtcact ttaagttaga    600

 taaagtgtat gtggcagaat tcccaagtcc cagaggactg ctccattggg agtagggaag    660

 acccagagca cggccagcca ggctggtaag cagttgccag gtggcaggaa gtggcttaca    720

 ctaagggttg aagcaaggca gagaagggaa aatgtgagca tttcaggaca aaacagaaac    780

 aaacaccaac atttcaggaa tgagaagcca gaagagaggg aaggtttggc caaaggactg    840

 gaaaggggca agaaaatgaa at atg aac cag gaa gct ata ggc aat cag cag     892
                          Met Asn Gln Glu Ala Ile Gly Asn Gln Gln
                            1               5                  10

 aag tcc aca gct aat ttg cat aat aaa agg aaa agt cat ctt gtt gga      940
 Lys Ser Thr Ala Asn Leu His Asn Lys Arg Lys Ser His Leu Val Gly
                  15                  20                  25

 att tgt ggt ggt ggc tgc cta gat ttg aaa ttg tat cct ata att tgc      988
 Ile Cys Gly Gly Gly Cys Leu Asp Leu Lys Leu Tyr Pro Ile Ile Cys
              30                  35                  40

 ccc att tcc agt gag aac cag cgt aaa aca ttt tta gaa caa aca gta     1036
 Pro Ile Ser Ser Glu Asn Gln Arg Lys Thr Phe Leu Glu Gln Thr Val
          45                  50                  55

 tat tgc aca agg ata gat tta caa caa aaa cta gtt ttt cta aga ctt     1084
 Tyr Cys Thr Arg Ile Asp Leu Gln Gln Lys Leu Val Phe Leu Arg Leu
      60                  65                  70

 gaa gcc ttc tgt ctt tta tca cag ggg gac cca gga agc cca atg atg     1132
 Glu Ala Phe Cys Leu Leu Ser Gln Gly Asp Pro Gly Ser Pro Met Met
  75                  80                  85                  90

 tgc cag cta cag cag ttc gat ctg tgg gtt ctg aga gga gtc ctg aac     1180
 Cys Gln Leu Gln Gln Phe Asp Leu Trp Val Leu Arg Gly Val Leu Asn
                  95                 100                 105

 ttc ggt ggt gag acg tgc cct ggc ctg ttt ctg tac acc aag gtg gaa     1228
 Phe Gly Gly Glu Thr Cys Pro Gly Leu Phe Leu Tyr Thr Lys Val Glu
             110                 115                 120

 gac tac agc aaa tgg atc aca tcc aag gct gag agg gcc ggc cct ccc     1276
 Asp Tyr Ser Lys Trp Ile Thr Ser Lys Ala Glu Arg Ala Gly Pro Pro
         125                 130                 135

 ctg tcc tca ctc cac cac tgg gaa aag ttg att tct ttc tcc cac cat     1324
 Leu Ser Ser Leu His His Trp Glu Lys Leu Ile Ser Phe Ser His His
     140                 145                 150

 gga cca aat gcc acc atg aca cag aag aca tat tct gat tct gaa ctg     1372
 Gly Pro Asn Ala Thr Met Thr Gln Lys Thr Tyr Ser Asp Ser Glu Leu
 155                 160                 165                 170

 ggc cat gtt gga tca tac ttg cag gga caa aga agg acc atc acg cat     1420
 Gly His Val Gly Ser Tyr Leu Gln Gly Gln Arg Arg Thr Ile Thr His
                 175                 180                 185

 tca cga cta gga aac agc tct aga gat agt cta gat gtt agg gag aag     1468
 Ser Arg Leu Gly Asn Ser Ser Arg Asp Ser Leu Asp Val Arg Glu Lys
             190                 195                 200

 gat gta aag gaa tca ggc agg tct cct gag gcg tct gta caa ccc tta     1516
 Asp Val Lys Glu Ser Gly Arg Ser Pro Glu Ala Ser Val Gln Pro Leu
         205                 210                 215

 tac tat gac tat tac ggt ggg gag gtg ggg gaa ggt agg att ttt gca     1564
 Tyr Tyr Asp Tyr Tyr Gly Gly Glu Val Gly Glu Gly Arg Ile Phe Ala
     220                 225                 230

 ggt cag aac agg ttg tat cag ccc gaa gaa atc atc ttg gtt tcc ttc     1612
 Gly Gln Asn Arg Leu Tyr Gln Pro Glu Glu Ile Ile Leu Val Ser Phe
 235                 240                 245                 250

 gtg ctt gtt ttc ttt tgc agc agt atc tag t ccaggagcta ccccaccaaa     1663
 Val Leu Val Phe Phe Cys Ser Ser Ile 
                 255

 ctgaagagta aactgagaat gctgagtgcc aggcattcac catgctgttt tgatgtctgt   1723

 ttttgatagt tgcacactgg ggctgccacg gataagccca tggcatacac tgggctggct   1783

 ctccctcctc tatccctctc ccaggtgtgg gaaggtcact ttcactatgc ttgtgaacta   1843

 aatgctggct aacaagtgtc aaaccattag agtgccctgt ggttctttca gtggtaacag   1903

 ttccaggggc caggctgtga aaacactccc catgggcaga tgtggcccag gagatgatac   1963

 tcagcctggg tggggggttg ggaacaccag gcagacaggg aacagtgaga ggagcccgtg   2023

 actagaaagg agctgattac ttttataggt catgtagtgg tctgtaagcc gtggcctgcc   2083

 tctggctact tcccagcaag gtaatctgcc tgcaactgct cattggttat tttcattcga   2143

 ttccaagcct tacgatggcc ttttaaggac atctctgcta tctccacttt cctttcccac   2203

 atcctgatgc tcttctccag gtccgcattt aagatcttct cccggacgta agtcatcacc   2263

 tgtggtgccc ggaactcggc cagctgcttc cggagcctct tattcactgc ctcggctttg   2323

 gcccggtcct cctctacttg tagtgtttct ttttcaattt tttcaagtag ctcttttctc   2383

 agcaagatct ccttgtccag attgaggtat atttccattg ccttgtgaag cttgcttttg   2443

 taggcattga gaacctgcag agtgtttcca gatgacagct ttagctgggt cagttcttga   2503

 ttccttgctt caattgtctc aagaaattga gcgttctcta tcttcaactg ctgaaaatca   2563

 acatcgtgaa gggcctcact cacctcttcc ttctgcctca attgtaaaag catttttttc   2623

 ctctgaactt tgagagaaac atttttcaaa cgtaatttct ccttcatatt atccctccgg   2683

 cggttcatgt cctcaatgta tttcatcact ttctgagtgg ccaaaatact ccctttcttc   2743

 ttggatatgg cttttagaat atctttttca aactcatgca cttctctcga aacttcactc   2803

 catcgaattt cagcctcctc aatgatcgcc tcgtgatgct gcaggtcgcg ttccgcattt   2863

 gcccttgtgt gtcgtaagtc atccttcatg tccgcaacct ctttttgtac cagctcaagt   2923

 ttttggtcgg cagtcaggcc taccccacgg tccatacctg tccgggattt ggatctacgc   2983

 ctgcctcgaa actgtgcata atctgctgct gatattttaa tttctgataa tcgtggaggt   3043

 cgctgatccc tgggctccag tttagcgtaa tatttctcaa acatctcagt ctcagttttg   3103

 agagcagagt ttacatagct gagctcctcc accagcccgc acagctggat aacaggcagc   3163

 tccagctccg acccttcatg ggagtcggag aggacgctct cggactcatc atcagtcatc   3223

 actctgccga agcggcccct gccaatgccg tgtgcccagg agctccgggt gccgg        3278




      <210> 26
      <211> 3930
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (87)..(3185)

      <400> 26
 agcggcgcgc ttccgggagg cttgtcccaa gctcacggac ccctcgctgg gtgccggtta     60

 agaccccgct ccccgtcgcc agtgct atg gag gcg gcg gcg gcg gtg gtg gcg     113
                              Met Glu Ala Ala Ala Ala Val Val Ala
                                1               5

 gca gag gcg gaa gtg gaa aac gaa gac ggc gac agc agc tgc ggg gat      161
 Ala Glu Ala Glu Val Glu Asn Glu Asp Gly Asp Ser Ser Cys Gly Asp
  10                  15                  20                  25

 gta tgc ttc atg gac aaa ggc ttg cag agc ata tca gaa tta tct tta      209
 Val Cys Phe Met Asp Lys Gly Leu Gln Ser Ile Ser Glu Leu Ser Leu
                  30                  35                  40

 gat tca act ctt cat gcc gtc aat ctt cat tgc aat aac atc tcc aag      257
 Asp Ser Thr Leu His Ala Val Asn Leu His Cys Asn Asn Ile Ser Lys
              45                  50                  55

 atc gaa gcc att gat cat att tgg aat tta caa cat cta gat ctg tca      305
 Ile Glu Ala Ile Asp His Ile Trp Asn Leu Gln His Leu Asp Leu Ser
          60                  65                  70

 tct aat caa ata agt aga att gaa gga cta aac aca ctg aca aaa ctg      353
 Ser Asn Gln Ile Ser Arg Ile Glu Gly Leu Asn Thr Leu Thr Lys Leu
      75                  80                  85

 tgc aca tta aat ttg tcc tgc aat ttg att aca aaa gta gaa gga ctt      401
 Cys Thr Leu Asn Leu Ser Cys Asn Leu Ile Thr Lys Val Glu Gly Leu
  90                  95                 100                 105

 gaa gaa cta att aat ctg act aga cta aat gta tct tat aac cac ata      449
 Glu Glu Leu Ile Asn Leu Thr Arg Leu Asn Val Ser Tyr Asn His Ile
                 110                 115                 120

 gat gat ctt agt gga ttg att ccc ctt cat gga att aag cat aaa ctt      497
 Asp Asp Leu Ser Gly Leu Ile Pro Leu His Gly Ile Lys His Lys Leu
             125                 130                 135

 aga tat att gat cta cat agt aat cgt ata gat agt atc cat cac tta      545
 Arg Tyr Ile Asp Leu His Ser Asn Arg Ile Asp Ser Ile His His Leu
         140                 145                 150

 ctt cag tgt atg gta gga ttg cac ttc ctg acc aat ctt att ttg gag      593
 Leu Gln Cys Met Val Gly Leu His Phe Leu Thr Asn Leu Ile Leu Glu
     155                 160                 165

 aaa gat gga gac gat aat cct gtc tgt cga ctg cca ggg tac aga gca      641
 Lys Asp Gly Asp Asp Asn Pro Val Cys Arg Leu Pro Gly Tyr Arg Ala
 170                 175                 180                 185

 gtt att ctc cag act ttg cca cag ctt aga atc cta gat tgc aag aac      689
 Val Ile Leu Gln Thr Leu Pro Gln Leu Arg Ile Leu Asp Cys Lys Asn
                 190                 195                 200

 ata ttt ggt gaa cca gta aat ttg aca gaa ata aat tca tca cag ctg      737
 Ile Phe Gly Glu Pro Val Asn Leu Thr Glu Ile Asn Ser Ser Gln Leu
             205                 210                 215

 cag tgc cta gaa ggt ctt ttg gat aat tta gtt tct tct gat tct ccc      785
 Gln Cys Leu Glu Gly Leu Leu Asp Asn Leu Val Ser Ser Asp Ser Pro
         220                 225                 230

 cta aat ata agt gaa gat gag atc att gat aga atg cca gtg ata aca      833
 Leu Asn Ile Ser Glu Asp Glu Ile Ile Asp Arg Met Pro Val Ile Thr
     235                 240                 245

 gca cct atc gat gag tta gtt ccc ttg gaa cag ttt gca agt aca cca      881
 Ala Pro Ile Asp Glu Leu Val Pro Leu Glu Gln Phe Ala Ser Thr Pro
 250                 255                 260                 265

 agt gat gct gtg ttg acg tct ttt atg tct gtg tgt caa tct tct gag      929
 Ser Asp Ala Val Leu Thr Ser Phe Met Ser Val Cys Gln Ser Ser Glu
                 270                 275                 280

 cca gag aaa aat aat cat gaa aac gat ttg cag aat gag ata aaa ctt      977
 Pro Glu Lys Asn Asn His Glu Asn Asp Leu Gln Asn Glu Ile Lys Leu
             285                 290                 295

 cag aaa tta gat gac caa att cta caa ctt cta aat gaa act tct aat     1025
 Gln Lys Leu Asp Asp Gln Ile Leu Gln Leu Leu Asn Glu Thr Ser Asn
         300                 305                 310

 tca ata gat aac gtt ctt gag aaa gac ccc aga cca aaa aga gac aca     1073
 Ser Ile Asp Asn Val Leu Glu Lys Asp Pro Arg Pro Lys Arg Asp Thr
     315                 320                 325

 gat ata act tct gaa agt gac tat gga aac aga aaa gaa tgc aat aga     1121
 Asp Ile Thr Ser Glu Ser Asp Tyr Gly Asn Arg Lys Glu Cys Asn Arg
 330                 335                 340                 345

 aaa gtt cct cga aga tca aaa atc cct tat gat gcc aaa acc att caa     1169
 Lys Val Pro Arg Arg Ser Lys Ile Pro Tyr Asp Ala Lys Thr Ile Gln
                 350                 355                 360

 act att aag cac cac aat aaa aac tac aac tct ttt gta agt tgt aat     1217
 Thr Ile Lys His His Asn Lys Asn Tyr Asn Ser Phe Val Ser Cys Asn
             365                 370                 375

 cgt aaa atg aaa cca cct tac ctt aaa gaa tta tat gta agc tca tct     1265
 Arg Lys Met Lys Pro Pro Tyr Leu Lys Glu Leu Tyr Val Ser Ser Ser
         380                 385                 390

 tta gca aac tgt cct atg tta caa gaa tca gaa aag cca aag act gaa     1313
 Leu Ala Asn Cys Pro Met Leu Gln Glu Ser Glu Lys Pro Lys Thr Glu
     395                 400                 405

 ata att aaa gta gac caa agt cac tca gaa gac aac act tac cag tcc     1361
 Ile Ile Lys Val Asp Gln Ser His Ser Glu Asp Asn Thr Tyr Gln Ser
 410                 415                 420                 425

 ctt gtt gaa cag cta gac caa gag aga gag aag aga tgg aga gct gag     1409
 Leu Val Glu Gln Leu Asp Gln Glu Arg Glu Lys Arg Trp Arg Ala Glu
                 430                 435                 440

 caa gcc gaa aat aaa ctc atg gat tat att gat gag ctg cat aaa cat     1457
 Gln Ala Glu Asn Lys Leu Met Asp Tyr Ile Asp Glu Leu His Lys His
             445                 450                 455

 gca aat gaa aaa gag gat att cat agt ctg gct cta ctt acc aca gat     1505
 Ala Asn Glu Lys Glu Asp Ile His Ser Leu Ala Leu Leu Thr Thr Asp
         460                 465                 470

 agg cta aag gaa att att ttt aga gag aga aat tcc aaa gga caa ctc     1553
 Arg Leu Lys Glu Ile Ile Phe Arg Glu Arg Asn Ser Lys Gly Gln Leu
     475                 480                 485

 gaa gtt atg gtt cac aaa ctt caa aat gaa att aaa aaa ctg act gtt     1601
 Glu Val Met Val His Lys Leu Gln Asn Glu Ile Lys Lys Leu Thr Val
 490                 495                 500                 505

 gaa cta atg aaa gca aaa gat caa caa gag gat cac ctt aaa cac tta     1649
 Glu Leu Met Lys Ala Lys Asp Gln Gln Glu Asp His Leu Lys His Leu
                 510                 515                 520

 aga acc ctc gaa aaa aca tta gaa aaa atg gag aga caa aaa agg cag     1697
 Arg Thr Leu Glu Lys Thr Leu Glu Lys Met Glu Arg Gln Lys Arg Gln
             525                 530                 535

 cag cag gca gca cag ata aga ctg atc caa gag gtg gaa ctc aaa gct     1745
 Gln Gln Ala Ala Gln Ile Arg Leu Ile Gln Glu Val Glu Leu Lys Ala
         540                 545                 550

 tca gct gcc gat aga gaa ata tac tta ctt aga act tcc ctt cat cga     1793
 Ser Ala Ala Asp Arg Glu Ile Tyr Leu Leu Arg Thr Ser Leu His Arg
     555                 560                 565

 gaa aga gaa caa gcg caa caa ctt cat caa ctt ctt gca ttg aaa gaa     1841
 Glu Arg Glu Gln Ala Gln Gln Leu His Gln Leu Leu Ala Leu Lys Glu
 570                 575                 580                 585

 cag gaa cac agg aag gaa ctt gaa aca agg gag ttt ttt act gat gct     1889
 Gln Glu His Arg Lys Glu Leu Glu Thr Arg Glu Phe Phe Thr Asp Ala
                 590                 595                 600

 gac ttc cag gat gcc tta gct aaa gaa ata gcc aaa gaa gag aaa aag     1937
 Asp Phe Gln Asp Ala Leu Ala Lys Glu Ile Ala Lys Glu Glu Lys Lys
             605                 610                 615

 cat gag caa atg ata aaa gaa tac caa gag aaa att gac gtg tta agc     1985
 His Glu Gln Met Ile Lys Glu Tyr Gln Glu Lys Ile Asp Val Leu Ser
         620                 625                 630

 cag cag tat atg gat tta gaa aat gaa ttc cgt att gct tta act gtt     2033
 Gln Gln Tyr Met Asp Leu Glu Asn Glu Phe Arg Ile Ala Leu Thr Val
     635                 640                 645

 gaa gcc aga aga ttt caa gat gtt aaa gat ggt ttt gaa aat gtt gca     2081
 Glu Ala Arg Arg Phe Gln Asp Val Lys Asp Gly Phe Glu Asn Val Ala
 650                 655                 660                 665

 act gag tta gca aag agc aaa cat gct ctt att tgg gct caa cga aaa     2129
 Thr Glu Leu Ala Lys Ser Lys His Ala Leu Ile Trp Ala Gln Arg Lys
                 670                 675                 680

 gaa aat gag tct tcc tct tta att aaa gat ctg acc tgt atg gta aag     2177
 Glu Asn Glu Ser Ser Ser Leu Ile Lys Asp Leu Thr Cys Met Val Lys
             685                 690                 695

 gaa caa aaa aca aaa ctg gca gaa gtt tct aaa ttg aaa caa gaa aca     2225
 Glu Gln Lys Thr Lys Leu Ala Glu Val Ser Lys Leu Lys Gln Glu Thr
         700                 705                 710

 gca gca aat tta cag aat caa atc aac acc ctt gaa att tta att gaa     2273
 Ala Ala Asn Leu Gln Asn Gln Ile Asn Thr Leu Glu Ile Leu Ile Glu
     715                 720                 725

 gat gac aag cag aag agt att caa ata gaa ctt ctc aag cac gaa aaa     2321
 Asp Asp Lys Gln Lys Ser Ile Gln Ile Glu Leu Leu Lys His Glu Lys
 730                 735                 740                 745

 gtc cag ctt att tct gag cta gca gcc aag gaa tca cta ata ttt ggt     2369
 Val Gln Leu Ile Ser Glu Leu Ala Ala Lys Glu Ser Leu Ile Phe Gly
                 750                 755                 760

 tta agg aca gaa aga aaa gta tgg gga cat gag ctg gca caa caa gga     2417
 Leu Arg Thr Glu Arg Lys Val Trp Gly His Glu Leu Ala Gln Gln Gly
             765                 770                 775

 tct tct cta gcc caa aat cgt gga aaa ttg gag gct caa att gag agt     2465
 Ser Ser Leu Ala Gln Asn Arg Gly Lys Leu Glu Ala Gln Ile Glu Ser
         780                 785                 790

 tta tct aga gag aat gaa tgt ctg cga aag aca aat gaa agt gat agt     2513
 Leu Ser Arg Glu Asn Glu Cys Leu Arg Lys Thr Asn Glu Ser Asp Ser
     795                 800                 805

 gat gca tta aga ata aag tgc aaa atc ata gac gac caa act gaa act     2561
 Asp Ala Leu Arg Ile Lys Cys Lys Ile Ile Asp Asp Gln Thr Glu Thr
 810                 815                 820                 825

 att aga aaa tta aaa gat tgt tta caa gaa aaa gat gaa cac atc aaa     2609
 Ile Arg Lys Leu Lys Asp Cys Leu Gln Glu Lys Asp Glu His Ile Lys
                 830                 835                 840

 aga tta caa gaa aag atc aca gaa ata gaa aaa tgc act caa gaa caa     2657
 Arg Leu Gln Glu Lys Ile Thr Glu Ile Glu Lys Cys Thr Gln Glu Gln
             845                 850                 855

 ctt gat gaa aaa tct tca caa ctg gat gag gta ctt gag aag ttg gaa     2705
 Leu Asp Glu Lys Ser Ser Gln Leu Asp Glu Val Leu Glu Lys Leu Glu
         860                 865                 870

 agg cac aat gaa aga aaa gaa aaa cta aaa caa cag ttg aaa gga aag     2753
 Arg His Asn Glu Arg Lys Glu Lys Leu Lys Gln Gln Leu Lys Gly Lys
     875                 880                 885

 gaa gta gaa ctt gaa gaa atc aga aaa gct tac agt aca ctg aat cgg     2801
 Glu Val Glu Leu Glu Glu Ile Arg Lys Ala Tyr Ser Thr Leu Asn Arg
 890                 895                 900                 905

 aag tgg cat gat aaa gga gaa ctt cta tgt cat ctt gaa aca caa gta     2849
 Lys Trp His Asp Lys Gly Glu Leu Leu Cys His Leu Glu Thr Gln Val
                 910                 915                 920

 aaa gaa gtg aaa gaa aaa ttt gaa aac aag gaa aag aaa ctt aaa gcg     2897
 Lys Glu Val Lys Glu Lys Phe Glu Asn Lys Glu Lys Lys Leu Lys Ala
             925                 930                 935

 gaa aga gac aaa agt att gaa cta caa aag aat gca atg gaa aaa ctt     2945
 Glu Arg Asp Lys Ser Ile Glu Leu Gln Lys Asn Ala Met Glu Lys Leu
         940                 945                 950

 cat agt atg gat gat gcc ttt aaa aga caa gtt gat gca att gtt gaa     2993
 His Ser Met Asp Asp Ala Phe Lys Arg Gln Val Asp Ala Ile Val Glu
     955                 960                 965

 gct cat caa gct gaa ata gca cag ctg gcc aat gaa aag cag aag tgt     3041
 Ala His Gln Ala Glu Ile Ala Gln Leu Ala Asn Glu Lys Gln Lys Cys
 970                 975                 980                 985

 att gat tct gca aat tta aag gtc cat caa att gaa aaa gaa atg cgt     3089
 Ile Asp Ser Ala Asn Leu Lys Val His Gln Ile Glu Lys Glu Met Arg
                 990                 995                1000

 gaa ctt ttg gaa gaa aca tgc aag aac aaa aaa aca atg gaa gca aaa     3137
 Glu Leu Leu Glu Glu Thr Cys Lys Asn Lys Lys Thr Met Glu Ala Lys
            1005                1010                1015

 att aag caa ctt gct ttt gct tta aat gaa att cag caa gat atg tga     3185
 Ile Lys Gln Leu Ala Phe Ala Leu Asn Glu Ile Gln Gln Asp Met 
        1020                1025                1030

 tggttctgag aatgaattta attgaaatag accagcagac ctattgtaaa aatgattaaa   3245

 tattgtaata gtagtaactg ctatgacttt gaaatgtctc tttctataca tttcattatg   3305

 aatatatttt taaagacttt tgatcaagta ttaattgtat aggtttttta taataaattg   3365

 ttgacaattt tgtctattag aaaaaactat cataactaga cttacaatat ttttcttgtt   3425

 tctgtactat acgttgtttg gtaattacac atttgcctac aaatttgtga atgaaaagat   3485

 tagtattttc accatatgag gtaaaacatt ttaatcattg ttatcttatt gtgatgatga   3545

 agaactaatt atatttgtta tttaattgat gtagctcaat tcttttaaag tacttatgta   3605

 gccaaaaagc atttgaaatc tgtatgataa aagatgtggc attcttaaga aagtatatgt   3665

 agccatctcc acatcactca ttatgacccc ttcttttata atgcttatat cttttcatta   3725

 aagattacat ttaaggtttt ataaatattg tctgttcctg aagaggaaca ccactgttcc   3785

 accttcattc tcccttctaa taactgtata tgaagaaatt ctgataatgt aactggaagc   3845

 agtaattcat ttcattccat accgggtcat tactgtatta ctgtttcact tttgtcacat   3905

 catatgctat gtatgcagga acaaa                                         3930




      <210> 27
      <211> 3773
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (339)..(3773)

      <400> 27
 ctcgtgggga aaaggcaggg agggggtggt gtccccagcc ggtttggggg gtgcgttgcc     60

 cggagacgga aagtttggga gcccgagcag gctcggctgc agcctcgggg agggggtcca    120

 gcgggtggcg gccctgggga tggggaagga gcaggagctg ctggcaggcg gcccgcaccg    180

 ggcacctccc ggcggtggag aagctgctgt ccgggaagcg gctctcctca ggctttgggg    240

 gcggcggcgg cggtggctct gggggcggcg gcggcggcag cggcggcggc ggcggcggcc    300

 tcggctcttc cagccacccc ctctccagtc tgctcagc    atg tgg aga ggg cca     353
                                              Met Trp Arg Gly Pro
                                                1               5

 aat gtg aac tgt gtt gac agc act ggc tac aca ccc ctg cac cat gct      401
 Asn Val Asn Cys Val Asp Ser Thr Gly Tyr Thr Pro Leu His His Ala
                  10                  15                  20

 gct ttg aat ggc cat aag gat gtg gtc gag gtt ctt ctg agg aac gat      449
 Ala Leu Asn Gly His Lys Asp Val Val Glu Val Leu Leu Arg Asn Asp
              25                  30                  35

 gcg ctg acc aac gtg gct gac tca aaa ggc tgc tac cct ctg cat ttg      497
 Ala Leu Thr Asn Val Ala Asp Ser Lys Gly Cys Tyr Pro Leu His Leu
          40                  45                  50

 gca gcc tgg aaa gga gat gcc cag ata gtg cgg ttg ctc atc cat caa      545
 Ala Ala Trp Lys Gly Asp Ala Gln Ile Val Arg Leu Leu Ile His Gln
      55                  60                  65

 ggg cct tca cac acc aga gtc aat gaa cag aac aat gac aac gag aca      593
 Gly Pro Ser His Thr Arg Val Asn Glu Gln Asn Asn Asp Asn Glu Thr
  70                  75                  80                  85

 gcc ctg cat tgt gca gcg cag tat ggc cac aca gag gtg gtg aag gtg      641
 Ala Leu His Cys Ala Ala Gln Tyr Gly His Thr Glu Val Val Lys Val
                  90                  95                 100

 ctc tta gag gag ctg acg gac ccc acc atg cgc aac aac aaa ttc gag      689
 Leu Leu Glu Glu Leu Thr Asp Pro Thr Met Arg Asn Asn Lys Phe Glu
             105                 110                 115

 acc cct ttg gac ctg gca gca ctg tac ggg cga ctg gag gtg gtg aaa      737
 Thr Pro Leu Asp Leu Ala Ala Leu Tyr Gly Arg Leu Glu Val Val Lys
         120                 125                 130

 atg ctc ctt aat gca cac ccc aac ctc ctg agc tgc aac act aag aag      785
 Met Leu Leu Asn Ala His Pro Asn Leu Leu Ser Cys Asn Thr Lys Lys
     135                 140                 145

 cac acc cct ctg cac ttg gca gca agg aat ggc cac aaa gcc gtg gtc      833
 His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Lys Ala Val Val
 150                 155                 160                 165

 cag gtc ctc ctc gat gct ggc atg gac agc aac tac cag acg gag atg      881
 Gln Val Leu Leu Asp Ala Gly Met Asp Ser Asn Tyr Gln Thr Glu Met
                 170                 175                 180

 ggc agt gct ttg cat gag gct gct ttg ttt ggc aag acc gat gtg gtg      929
 Gly Ser Ala Leu His Glu Ala Ala Leu Phe Gly Lys Thr Asp Val Val
             185                 190                 195

 caa atc ctg ctg gct gca gga act gac gtc aac ata aaa gat aac cat      977
 Gln Ile Leu Leu Ala Ala Gly Thr Asp Val Asn Ile Lys Asp Asn His
         200                 205                 210

 gga ctg act gcc cta gac act gtt cgg gaa ctg cct tct caa aag agc     1025
 Gly Leu Thr Ala Leu Asp Thr Val Arg Glu Leu Pro Ser Gln Lys Ser
     215                 220                 225

 cag caa ata gca gca tta att gaa gat cac atg act gga aaa aga agt     1073
 Gln Gln Ile Ala Ala Leu Ile Glu Asp His Met Thr Gly Lys Arg Ser
 230                 235                 240                 245

 aca aaa gaa gta gat aaa acc ccc cca ccc cag cca cct ctc atc tcc     1121
 Thr Lys Glu Val Asp Lys Thr Pro Pro Pro Gln Pro Pro Leu Ile Ser
                 250                 255                 260

 agt atg gac tcc ata tca cag aag tct cag ggt gac gtg gag aaa gca     1169
 Ser Met Asp Ser Ile Ser Gln Lys Ser Gln Gly Asp Val Glu Lys Ala
             265                 270                 275

 gtg act gaa ctg att ata gat ttt gat gca aat gct gaa gaa gag ggt     1217
 Val Thr Glu Leu Ile Ile Asp Phe Asp Ala Asn Ala Glu Glu Glu Gly
         280                 285                 290

 ccc tac gaa gct ctg tat aat gcc atc tcc tgc cat tcg ttg gac agc     1265
 Pro Tyr Glu Ala Leu Tyr Asn Ala Ile Ser Cys His Ser Leu Asp Ser
     295                 300                 305

 atg gcc agc ggg cga tca tct gac caa gac tcc acg aac aag gag gct     1313
 Met Ala Ser Gly Arg Ser Ser Asp Gln Asp Ser Thr Asn Lys Glu Ala
 310                 315                 320                 325

 gag gca gca gga gtg aaa cct gct gga gtg agg cct agg gaa cgt cca     1361
 Glu Ala Ala Gly Val Lys Pro Ala Gly Val Arg Pro Arg Glu Arg Pro
                 330                 335                 340

 cca cct cca gca aag cca ccg ccc gat gaa gag gaa gaa gac cac ata     1409
 Pro Pro Pro Ala Lys Pro Pro Pro Asp Glu Glu Glu Glu Asp His Ile
             345                 350                 355

 gat aag aag tat ttt ccc ttg aca gct tct gag gtt ctg tcc atg aga     1457
 Asp Lys Lys Tyr Phe Pro Leu Thr Ala Ser Glu Val Leu Ser Met Arg
         360                 365                 370

 cct agg att cat ggg agt gca gcc cgg gaa gaa gac gaa cac cct tat     1505
 Pro Arg Ile His Gly Ser Ala Ala Arg Glu Glu Asp Glu His Pro Tyr
     375                 380                 385

 gaa ctg ttg tta aca gca gag aca aag aaa gtg gtg ttg gtg gat gga     1553
 Glu Leu Leu Leu Thr Ala Glu Thr Lys Lys Val Val Leu Val Asp Gly
 390                 395                 400                 405

 aaa aca aaa gac cac agg cgg agc agc agc agc cgg agc cag gac tct     1601
 Lys Thr Lys Asp His Arg Arg Ser Ser Ser Ser Arg Ser Gln Asp Ser
                 410                 415                 420

 gcg gag ggg cag gac ggg cag gtc cca gag cag ttc tca ggc ctc ctc     1649
 Ala Glu Gly Gln Asp Gly Gln Val Pro Glu Gln Phe Ser Gly Leu Leu
             425                 430                 435

 cac ggc tcc tcc ccg gtg tgc gag gtg ggg cag gac cct ttc cag ctg     1697
 His Gly Ser Ser Pro Val Cys Glu Val Gly Gln Asp Pro Phe Gln Leu
         440                 445                 450

 ctc tgt acc gct ggc cag agc cat cca gac ggg tcc ccc cag cag ggc     1745
 Leu Cys Thr Ala Gly Gln Ser His Pro Asp Gly Ser Pro Gln Gln Gly
     455                 460                 465

 gcc tgc cac aag gcc agc atg cag ctg gag gag acg ggt gtg cat gct     1793
 Ala Cys His Lys Ala Ser Met Gln Leu Glu Glu Thr Gly Val His Ala
 470                 475                 480                 485

 cct gga gcc tcc cag ccc agt gcc ctg gac cag agc aag aga gtg ggc     1841
 Pro Gly Ala Ser Gln Pro Ser Ala Leu Asp Gln Ser Lys Arg Val Gly
                 490                 495                 500

 tac ctc aca ggc ctg ccc acc acc aac agc cgc tcg cac cct gaa act     1889
 Tyr Leu Thr Gly Leu Pro Thr Thr Asn Ser Arg Ser His Pro Glu Thr
             505                 510                 515

 ttg act cac aca gca tct ccg cac cct ggt ggt gct gag gaa gga gac     1937
 Leu Thr His Thr Ala Ser Pro His Pro Gly Gly Ala Glu Glu Gly Asp
         520                 525                 530

 cgg agt ggg gcc agg agc cga gcg cct ccc act agc aaa ccc aaa gct     1985
 Arg Ser Gly Ala Arg Ser Arg Ala Pro Pro Thr Ser Lys Pro Lys Ala
     535                 540                 545

 gaa ctc aaa ctc agc cgc agc ttg tcc aag tct gac tct gat ctc ctg     2033
 Glu Leu Lys Leu Ser Arg Ser Leu Ser Lys Ser Asp Ser Asp Leu Leu
 550                 555                 560                 565

 acc tgc tca ccc aca gag gac gct acc atg ggg agt cgg agt gag tcc     2081
 Thr Cys Ser Pro Thr Glu Asp Ala Thr Met Gly Ser Arg Ser Glu Ser
                 570                 575                 580

 tta tcc aac tgc agc att ggg aag aaa agg cta gag aag tca ccc tcc     2129
 Leu Ser Asn Cys Ser Ile Gly Lys Lys Arg Leu Glu Lys Ser Pro Ser
             585                 590                 595

 ttc gcc tcg gag tgg gat gag att gag aaa atc atg agt tct att gga     2177
 Phe Ala Ser Glu Trp Asp Glu Ile Glu Lys Ile Met Ser Ser Ile Gly
         600                 605                 610

 gaa ggg att gac ttt tct cag gaa cgg cag aag atc tcg ggt tca cgg     2225
 Glu Gly Ile Asp Phe Ser Gln Glu Arg Gln Lys Ile Ser Gly Ser Arg
     615                 620                 625

 acg ctg gag cag agt gtc ggg gag tgg ctg gag tcg att ggg ctg cag     2273
 Thr Leu Glu Gln Ser Val Gly Glu Trp Leu Glu Ser Ile Gly Leu Gln
 630                 635                 640                 645

 cag tat gag agc aag ttg ctt ctg aat ggc ttt gac gat gtc cac ttc     2321
 Gln Tyr Glu Ser Lys Leu Leu Leu Asn Gly Phe Asp Asp Val His Phe
                 650                 655                 660

 ctg ggg tct aat gtg atg gaa gag cag gac ctg cgg gac atc ggc atc     2369
 Leu Gly Ser Asn Val Met Glu Glu Gln Asp Leu Arg Asp Ile Gly Ile
             665                 670                 675

 agc gac cca cag cac cgg cgg aag ctg ctc cag gcg gca cgc tcc cta     2417
 Ser Asp Pro Gln His Arg Arg Lys Leu Leu Gln Ala Ala Arg Ser Leu
         680                 685                 690

 ccc aag gtg aag gct ctg ggt tat gac ggg aac agc ccc cct agc gtg     2465
 Pro Lys Val Lys Ala Leu Gly Tyr Asp Gly Asn Ser Pro Pro Ser Val
     695                 700                 705

 ccc tcc tgg ctg gac tcc ctg ggg ctg cag gac tac gtc cat tcc ttc     2513
 Pro Ser Trp Leu Asp Ser Leu Gly Leu Gln Asp Tyr Val His Ser Phe
 710                 715                 720                 725

 ttg tca agt ggt tac agc tcc att gac acc gtg aag aac ctc tgg gag     2561
 Leu Ser Ser Gly Tyr Ser Ser Ile Asp Thr Val Lys Asn Leu Trp Glu
                 730                 735                 740

 cta gag ctc gtc aat gtc ctg aag gtc cag ctg ctc ggc cat cgc aag     2609
 Leu Glu Leu Val Asn Val Leu Lys Val Gln Leu Leu Gly His Arg Lys
             745                 750                 755

 cgc atc atc gcc tcc ctc gca gac aga ccg tac gag gag ccg ccc cag     2657
 Arg Ile Ile Ala Ser Leu Ala Asp Arg Pro Tyr Glu Glu Pro Pro Gln
         760                 765                 770

 aag ccc ccc aga ttc tcc cag ctg agg tgc caa gat ttg ctc tcc cag     2705
 Lys Pro Pro Arg Phe Ser Gln Leu Arg Cys Gln Asp Leu Leu Ser Gln
     775                 780                 785

 acg tca tcc cca ctg agt cag aat gat tcc tgc act ggg cgg tcg gca     2753
 Thr Ser Ser Pro Leu Ser Gln Asn Asp Ser Cys Thr Gly Arg Ser Ala
 790                 795                 800                 805

 gat ctg ctg ctg cct cca ggg gac aca ggc agg agg cgc cat gac agt     2801
 Asp Leu Leu Leu Pro Pro Gly Asp Thr Gly Arg Arg Arg His Asp Ser
                 810                 815                 820

 ctc cat gac cct gcg gca ccc tcc cga gcg gag cgc ttc agg atc cag     2849
 Leu His Asp Pro Ala Ala Pro Ser Arg Ala Glu Arg Phe Arg Ile Gln
             825                 830                 835

 gag gag cac cgt gag gcc aag ctg acc ctg cgg ccc cca agc ctg gca     2897
 Glu Glu His Arg Glu Ala Lys Leu Thr Leu Arg Pro Pro Ser Leu Ala
         840                 845                 850

 gcc ccc tac gcc cca gtg cag agt tgg caa cac cag cca gag aaa ctc     2945
 Ala Pro Tyr Ala Pro Val Gln Ser Trp Gln His Gln Pro Glu Lys Leu
     855                 860                 865

 atc ttc gag tcc tgt ggt tat gaa gcc aat tat ctg ggc tcc atg ctg     2993
 Ile Phe Glu Ser Cys Gly Tyr Glu Ala Asn Tyr Leu Gly Ser Met Leu
 870                 875                 880                 885

 atc aaa gat ctg cga ggg aca gaa tcc acg caa gac gcc tgt gcc aag     3041
 Ile Lys Asp Leu Arg Gly Thr Glu Ser Thr Gln Asp Ala Cys Ala Lys
                 890                 895                 900

 atg cgg aaa tct acg gag cac atg aag aag atc ccc acc atc atc ctg     3089
 Met Arg Lys Ser Thr Glu His Met Lys Lys Ile Pro Thr Ile Ile Leu
             905                 910                 915

 tcc atc aca tac aaa ggt gtc aag ttc atc gat gcc tcc aac aag aac     3137
 Ser Ile Thr Tyr Lys Gly Val Lys Phe Ile Asp Ala Ser Asn Lys Asn
         920                 925                 930

 gtc att gca gag cac gag atc cgg aac att tcc tgt gcg gcc cag gac     3185
 Val Ile Ala Glu His Glu Ile Arg Asn Ile Ser Cys Ala Ala Gln Asp
     935                 940                 945

 ccg gag gac ctc tgt acc ttt gcc tac atc acc aag gac ctg cag acc     3233
 Pro Glu Asp Leu Cys Thr Phe Ala Tyr Ile Thr Lys Asp Leu Gln Thr
 950                 955                 960                 965

 agc cac cac tat tgc cat gtg ttc agc acc gtg gat gtg aac ctg acc     3281
 Ser His His Tyr Cys His Val Phe Ser Thr Val Asp Val Asn Leu Thr
                 970                 975                 980

 tac gag atc atc ctg acg ctg ggg cag gcc ttc gaa gtg gcc tat cag     3329
 Tyr Glu Ile Ile Leu Thr Leu Gly Gln Ala Phe Glu Val Ala Tyr Gln
             985                 990                 995

 ttg gcc ctg cag gcc cag aag tcc agg gcg acg ggc gcc tct gca gct     3377
 Leu Ala Leu Gln Ala Gln Lys Ser Arg Ala Thr Gly Ala Ser Ala Ala
        1000                1005                1010

 gag atg att gaa aca aaa tct tcc aaa ccg gtg cct aag cct cgg gtc     3425
 Glu Met Ile Glu Thr Lys Ser Ser Lys Pro Val Pro Lys Pro Arg Val
    1015                1020                1025

 ggc gtg agg aaa tcc gca gag gtg ggt ggc acg tgt gtg gac agc ccc     3473
 Gly Val Arg Lys Ser Ala Glu Val Gly Gly Thr Cys Val Asp Ser Pro
1030                1035                1040                1045

 tct atc ttc gcc atg gag tct caa ggc ctg gca gcc ttg ggc ctg gct     3521
 Ser Ile Phe Ala Met Glu Ser Gln Gly Leu Ala Ala Leu Gly Leu Ala
                1050                1055                1060

 ctg gag tct agc tca ctg agg agg aag gcc ttc cgt aga acc aac gag     3569
 Leu Glu Ser Ser Ser Leu Arg Arg Lys Ala Phe Arg Arg Thr Asn Glu
            1065                1070                1075

 gag gcg gcc tgt gcc ctg cac aca cgg cgc acc ttc ttc cct cac aga     3617
 Glu Ala Ala Cys Ala Leu His Thr Arg Arg Thr Phe Phe Pro His Arg
        1080                1085                1090

 aca gag ctg ctg gag gac agg gac ctg gac caa gtg gcc tcc att gtc     3665
 Thr Glu Leu Leu Glu Asp Arg Asp Leu Asp Gln Val Ala Ser Ile Val
    1095                1100                1105

 ctc tgg gag ctt tct gac act ctc cac ggg cct gtg agg atg ccc atg     3713
 Leu Trp Glu Leu Ser Asp Thr Leu His Gly Pro Val Arg Met Pro Met
1110                1115                1120                1125

 agc tac cgc tgt aca gtt ctc ggc ccc ggc ttt ctt cca aga gtt gac     3761
 Ser Tyr Arg Cys Thr Val Leu Gly Pro Gly Phe Leu Pro Arg Val Asp
                1130                1135                1140

 cag gaa ccc taa                                                     3773
 Gln Glu Pro 






      <210> 28
      <211> 3774
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (142)..(3774)

      <400> 28
 cgctcgtggg gaaaaggcag ggagggggtg gtgtccccag ccggtttggg gggtgcgttg     60

 cccggagacg gaaagtttgg gagcccgagc aggctcggct gcagcctcgg ggagggggtc    120

 cagcgggtgg cggccctggg g  atg ggg aag gag cag gag ctg ctg gag gcg     171
                          Met Gly Lys Glu Gln Glu Leu Leu Glu Ala
                            1               5                  10

 gcc cgc acc ggg cac ctc ccg gcg gtg gag aag ctg ctg tcc ggg aag      219
 Ala Arg Thr Gly His Leu Pro Ala Val Glu Lys Leu Leu Ser Gly Lys
                  15                  20                  25

 cgg ctc tcc tca ggc ttt ggg ggc ggc ggc ggc ggt ggc tct ggg ggc      267
 Arg Leu Ser Ser Gly Phe Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly
              30                  35                  40

 ggc ggc ggc ggc agc ggc ggc ggc ggc ggc ggc ctc ggc tct tcc agc      315
 Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Leu Gly Ser Ser Ser
          45                  50                  55

 cac ccc ctc tcc agt ctg ctc agc atg tgg aga ggg cca aat gtg aac      363
 His Pro Leu Ser Ser Leu Leu Ser Met Trp Arg Gly Pro Asn Val Asn
      60                  65                  70

 tgt gtt gac agc act ggc tac aca ccc ctg cac cat gct gct ttg aat      411
 Cys Val Asp Ser Thr Gly Tyr Thr Pro Leu His His Ala Ala Leu Asn
  75                  80                  85                  90

 ggc cat aag gat gtg gtc gag gtt ctt ctg agg aac gat gcg ctg acc      459
 Gly His Lys Asp Val Val Glu Val Leu Leu Arg Asn Asp Ala Leu Thr
                  95                 100                 105

 aac gtg gct gac tca aaa ggc tgc tac cct ctg cat ttg gca gcc tgg      507
 Asn Val Ala Asp Ser Lys Gly Cys Tyr Pro Leu His Leu Ala Ala Trp
             110                 115                 120

 aaa gga gat gcc cag ata gtg cgg ttg ctc atc cat caa ggg cct tca      555
 Lys Gly Asp Ala Gln Ile Val Arg Leu Leu Ile His Gln Gly Pro Ser
         125                 130                 135

 cac acc aga gtc aat gaa cag aac aat gac aac gag aca gcc ctg cat      603
 His Thr Arg Val Asn Glu Gln Asn Asn Asp Asn Glu Thr Ala Leu His
     140                 145                 150

 tgt gca gcg cag tat ggc cac aca gag gtg gtg aag gtg ctc tta gag      651
 Cys Ala Ala Gln Tyr Gly His Thr Glu Val Val Lys Val Leu Leu Glu
 155                 160                 165                 170

 gag ctg acg gac ccc acc atg cgc aac aac aaa ttc gag acc cct ttg      699
 Glu Leu Thr Asp Pro Thr Met Arg Asn Asn Lys Phe Glu Thr Pro Leu
                 175                 180                 185

 gac ctg gca gca ctg tac ggg cga ctg gag gtg gtg aaa atg ctc ctt      747
 Asp Leu Ala Ala Leu Tyr Gly Arg Leu Glu Val Val Lys Met Leu Leu
             190                 195                 200

 aat gca cac ccc aac ctc ctg agc tgc aac act aag aag cac acc cct      795
 Asn Ala His Pro Asn Leu Leu Ser Cys Asn Thr Lys Lys His Thr Pro
         205                 210                 215

 ctg cac ttg gca gca agg aat ggc cac aaa gcc gtg gtc cag gtc ctc      843
 Leu His Leu Ala Ala Arg Asn Gly His Lys Ala Val Val Gln Val Leu
     220                 225                 230

 ctc gat gct ggc atg gac agc aac tac cag acg gag atg ggc agt gct      891
 Leu Asp Ala Gly Met Asp Ser Asn Tyr Gln Thr Glu Met Gly Ser Ala
 235                 240                 245                 250

 ttg cat gag gct gct ttg ttt ggc aag acc gat gtg gtg caa atc ctg      939
 Leu His Glu Ala Ala Leu Phe Gly Lys Thr Asp Val Val Gln Ile Leu
                 255                 260                 265

 ctg gct gca gga act gac gtc aac ata aaa gat aac cat gga ctg act      987
 Leu Ala Ala Gly Thr Asp Val Asn Ile Lys Asp Asn His Gly Leu Thr
             270                 275                 280

 gcc cta gac act gtt cgg gaa ctg cct tct caa aag agc cag caa ata     1035
 Ala Leu Asp Thr Val Arg Glu Leu Pro Ser Gln Lys Ser Gln Gln Ile
         285                 290                 295

 gca gca tta att gaa gat cac atg act gga aaa aga agt aca aaa gaa     1083
 Ala Ala Leu Ile Glu Asp His Met Thr Gly Lys Arg Ser Thr Lys Glu
     300                 305                 310

 gta gat aaa acc ccc cca ccc cag cca cct ctc atc tcc agt atg gac     1131
 Val Asp Lys Thr Pro Pro Pro Gln Pro Pro Leu Ile Ser Ser Met Asp
 315                 320                 325                 330

 tcc ata tca cag aag tct cag ggt gac gtg gag aaa gca gtg act gaa     1179
 Ser Ile Ser Gln Lys Ser Gln Gly Asp Val Glu Lys Ala Val Thr Glu
                 335                 340                 345

 ctg att ata gat ttt gat gca aat gct gaa gaa gag ggt ccc tac gaa     1227
 Leu Ile Ile Asp Phe Asp Ala Asn Ala Glu Glu Glu Gly Pro Tyr Glu
             350                 355                 360

 gct ctg tat aat gcc atc tcc tgc cat tcg ttg gac agc atg gcc agc     1275
 Ala Leu Tyr Asn Ala Ile Ser Cys His Ser Leu Asp Ser Met Ala Ser
         365                 370                 375

 ggg cga tca tct gac caa gac tcc acg aac aag gag gct gag gca gca     1323
 Gly Arg Ser Ser Asp Gln Asp Ser Thr Asn Lys Glu Ala Glu Ala Ala
     380                 385                 390

 gga gtg aaa cct gct gga gtg agg cct agg gaa cgt cca cca cct cca     1371
 Gly Val Lys Pro Ala Gly Val Arg Pro Arg Glu Arg Pro Pro Pro Pro
 395                 400                 405                 410

 gca aag cca ccg ccc gat gaa gag gaa gaa gac cac ata gat aag aag     1419
 Ala Lys Pro Pro Pro Asp Glu Glu Glu Glu Asp His Ile Asp Lys Lys
                 415                 420                 425

 tat ttt ccc ttg aca gct tct gag gtt ctg tcc atg aga cct agg att     1467
 Tyr Phe Pro Leu Thr Ala Ser Glu Val Leu Ser Met Arg Pro Arg Ile
             430                 435                 440

 cat ggg agt gca gcc cgg gaa gaa gac gaa cac cct tat gaa ctg ttg     1515
 His Gly Ser Ala Ala Arg Glu Glu Asp Glu His Pro Tyr Glu Leu Leu
         445                 450                 455

 tta aca gca gag aca aag aaa gtg gtg ttg gtg gat gga aaa aca aaa     1563
 Leu Thr Ala Glu Thr Lys Lys Val Val Leu Val Asp Gly Lys Thr Lys
     460                 465                 470

 gac cac agg cgg agc agc agc agc cgg agc cag gac tct gcg gag ggg     1611
 Asp His Arg Arg Ser Ser Ser Ser Arg Ser Gln Asp Ser Ala Glu Gly
 475                 480                 485                 490

 cag gac ggg cag gtc cca gag cag ttc tca ggc ctc ctc cac ggc tcc     1659
 Gln Asp Gly Gln Val Pro Glu Gln Phe Ser Gly Leu Leu His Gly Ser
                 495                 500                 505

 tcc ccg gtg tgc gag gtg ggg cag gac cct ttc cag ctg ctc tgt acc     1707
 Ser Pro Val Cys Glu Val Gly Gln Asp Pro Phe Gln Leu Leu Cys Thr
             510                 515                 520

 gct ggc cag agc cat cca gac ggg tcc ccc cag cag ggc gcc tgc cac     1755
 Ala Gly Gln Ser His Pro Asp Gly Ser Pro Gln Gln Gly Ala Cys His
         525                 530                 535

 aag gcc agc atg cag ctg gag gag acg ggt gtg cat gct cct gga gcc     1803
 Lys Ala Ser Met Gln Leu Glu Glu Thr Gly Val His Ala Pro Gly Ala
     540                 545                 550

 tcc cag ccc agt gcc ctg gac cag agc aag aga gtg ggc tac ctc aca     1851
 Ser Gln Pro Ser Ala Leu Asp Gln Ser Lys Arg Val Gly Tyr Leu Thr
 555                 560                 565                 570

 ggc ctg ccc acc acc aac agc cgc tcg cac cct gaa act ttg act cac     1899
 Gly Leu Pro Thr Thr Asn Ser Arg Ser His Pro Glu Thr Leu Thr His
                 575                 580                 585

 aca gca tct ccg cac cct ggt ggt gct gag gaa gga gac cgg agt ggg     1947
 Thr Ala Ser Pro His Pro Gly Gly Ala Glu Glu Gly Asp Arg Ser Gly
             590                 595                 600

 gcc agg agc cga gcg cct ccc act agc aaa ccc aaa gct gaa ctc aaa     1995
 Ala Arg Ser Arg Ala Pro Pro Thr Ser Lys Pro Lys Ala Glu Leu Lys
         605                 610                 615

 ctc agc cgc agc ttg tcc aag tct gac tct gat ctc ctg acc tgc tca     2043
 Leu Ser Arg Ser Leu Ser Lys Ser Asp Ser Asp Leu Leu Thr Cys Ser
     620                 625                 630

 ccc aca gag gac gct acc atg ggg agt cgg agt gag tcc tta tcc aac     2091
 Pro Thr Glu Asp Ala Thr Met Gly Ser Arg Ser Glu Ser Leu Ser Asn
 635                 640                 645                 650

 tgc agc att ggg aag aaa agg cta gag aag tca ccc tcc ttc gcc tcg     2139
 Cys Ser Ile Gly Lys Lys Arg Leu Glu Lys Ser Pro Ser Phe Ala Ser
                 655                 660                 665

 gag tgg gat gag att gag aaa atc atg agt tct att gga gaa ggg att     2187
 Glu Trp Asp Glu Ile Glu Lys Ile Met Ser Ser Ile Gly Glu Gly Ile
             670                 675                 680

 gac ttt tct cag gaa cgg cag aag atc tca ggt tca cgg acg ctg gag     2235
 Asp Phe Ser Gln Glu Arg Gln Lys Ile Ser Gly Ser Arg Thr Leu Glu
         685                 690                 695

 cag agt gtc ggg gag tgg ctg gag tcg att ggg ctg cag cag tat gag     2283
 Gln Ser Val Gly Glu Trp Leu Glu Ser Ile Gly Leu Gln Gln Tyr Glu
     700                 705                 710

 agc aag ttg ctt ctg aat ggc ttt gac gat gtc cac ttc ctg ggg tct     2331
 Ser Lys Leu Leu Leu Asn Gly Phe Asp Asp Val His Phe Leu Gly Ser
 715                 720                 725                 730

 aat gtg atg gaa gag cag gac ctg cgg gac atc ggc atc agc gac cca     2379
 Asn Val Met Glu Glu Gln Asp Leu Arg Asp Ile Gly Ile Ser Asp Pro
                 735                 740                 745

 cag cac cgg cgg aag ctg ctc cag gcg gca cgc tcc cta ccc aag gtg     2427
 Gln His Arg Arg Lys Leu Leu Gln Ala Ala Arg Ser Leu Pro Lys Val
             750                 755                 760

 aag gct ctg ggt tat gac ggg aac agc ccc cct agc gtg ccc tcc tgg     2475
 Lys Ala Leu Gly Tyr Asp Gly Asn Ser Pro Pro Ser Val Pro Ser Trp
         765                 770                 775

 ctg gac tcc ctg ggg ctg cag gac tac gtc cat tcc ttc ttg tca agt     2523
 Leu Asp Ser Leu Gly Leu Gln Asp Tyr Val His Ser Phe Leu Ser Ser
     780                 785                 790

 ggt tac agc tcc att gac acc gtg aag aac ctc tgg gag cta gag ctc     2571
 Gly Tyr Ser Ser Ile Asp Thr Val Lys Asn Leu Trp Glu Leu Glu Leu
 795                 800                 805                 810

 gtc aat gtc ctg aag gtc cag ctg ctc ggc cat cgc aag cgc atc atc     2619
 Val Asn Val Leu Lys Val Gln Leu Leu Gly His Arg Lys Arg Ile Ile
                 815                 820                 825

 gcc tcc ctc gca gac aga ccg tac gag gag ccg ccc cag aag ccc ccc     2667
 Ala Ser Leu Ala Asp Arg Pro Tyr Glu Glu Pro Pro Gln Lys Pro Pro
             830                 835                 840

 aga ttc tcc cag ctg agg tgc caa gat ttg ctc tcc cag acg tca tcc     2715
 Arg Phe Ser Gln Leu Arg Cys Gln Asp Leu Leu Ser Gln Thr Ser Ser
         845                 850                 855

 cca ctg agt cag aat gat tcc tgc act ggg cgg tcg gca gat ctg ctg     2763
 Pro Leu Ser Gln Asn Asp Ser Cys Thr Gly Arg Ser Ala Asp Leu Leu
     860                 865                 870

 ctg cct cca ggg gac aca ggc agg agg cgc cat gac agt ctc cat gac     2811
 Leu Pro Pro Gly Asp Thr Gly Arg Arg Arg His Asp Ser Leu His Asp
 875                 880                 885                 890

 cct gcg gca ccc tcc cga gcg gag cgc ttc agg atc cag gag gag cac     2859
 Pro Ala Ala Pro Ser Arg Ala Glu Arg Phe Arg Ile Gln Glu Glu His
                 895                 900                 905

 cgt gag gcc aag ctg acc ctg cgg ccc cca agc ctg gca gcc ccc tac     2907
 Arg Glu Ala Lys Leu Thr Leu Arg Pro Pro Ser Leu Ala Ala Pro Tyr
             910                 915                 920

 gcc cca gtg cag agt tgg caa cac cag cca gag aaa ctc atc ttc gag     2955
 Ala Pro Val Gln Ser Trp Gln His Gln Pro Glu Lys Leu Ile Phe Glu
         925                 930                 935

 tcc tgt ggt tat gaa gcc aat tat ctg ggc tcc atg ctg atc aaa gat     3003
 Ser Cys Gly Tyr Glu Ala Asn Tyr Leu Gly Ser Met Leu Ile Lys Asp
     940                 945                 950

 ctg cga ggg aca gaa tcc acg caa gac gcc tgt gcc aag atg cgg aaa     3051
 Leu Arg Gly Thr Glu Ser Thr Gln Asp Ala Cys Ala Lys Met Arg Lys
 955                 960                 965                 970

 tct acg gag cac atg aag aag atc ccc acc atc atc ctg tcc atc aca     3099
 Ser Thr Glu His Met Lys Lys Ile Pro Thr Ile Ile Leu Ser Ile Thr
                 975                 980                 985

 tac aaa ggt gtc aag ttc atc gat gcc tcc aac aag aac gtc att gca     3147
 Tyr Lys Gly Val Lys Phe Ile Asp Ala Ser Asn Lys Asn Val Ile Ala
             990                 995                1000

 gag cac gag atc cgg aac att tcc tgt gcg gcc cag gac ccg gag gac     3195
 Glu His Glu Ile Arg Asn Ile Ser Cys Ala Ala Gln Asp Pro Glu Asp
        1005                1010                1015

 ctc tgt acc ttt gcc tac atc acc aag gac ctg cag acc agc cac cac     3243
 Leu Cys Thr Phe Ala Tyr Ile Thr Lys Asp Leu Gln Thr Ser His His
    1020                1025                1030

 tat tgc cat gtg ttc agc acc gtg gat gtg aac ctg acc tac gag atc     3291
 Tyr Cys His Val Phe Ser Thr Val Asp Val Asn Leu Thr Tyr Glu Ile
1035                1040                1045                1050

 atc ctg acg ctg ggg cag gcc ttc gaa gtg gcc tat cag ttg gcc ctg     3339
 Ile Leu Thr Leu Gly Gln Ala Phe Glu Val Ala Tyr Gln Leu Ala Leu
                1055                1060                1065

 cag gcc cag aag tcc agg gcg acg ggc gcc tct gca gct gag atg att     3387
 Gln Ala Gln Lys Ser Arg Ala Thr Gly Ala Ser Ala Ala Glu Met Ile
            1070                1075                1080

 gaa aca aaa tct tcc aaa ccg gtg cct aag cct cgg gtc ggc gtg agg     3435
 Glu Thr Lys Ser Ser Lys Pro Val Pro Lys Pro Arg Val Gly Val Arg
        1085                1090                1095

 aaa tcc gca gag gtg ggt ggc acg tgt gtg gac agc ccc tct atc ttc     3483
 Lys Ser Ala Glu Val Gly Gly Thr Cys Val Asp Ser Pro Ser Ile Phe
    1100                1105                1110

 gcc atg gag tct caa ggc ctg gca gcc ttg ggc ctg gct ctg gag tct     3531
 Ala Met Glu Ser Gln Gly Leu Ala Ala Leu Gly Leu Ala Leu Glu Ser
1115                1120                1125                1130

 agc tca ctg agg agg aag gcc ttc cgt aga acc aac gag gag gcg gcc     3579
 Ser Ser Leu Arg Arg Lys Ala Phe Arg Arg Thr Asn Glu Glu Ala Ala
                1135                1140                1145

 tgt gcc ctg cac aca cgg cgc acc ttc ttc cct cac aga aca gag ctg     3627
 Cys Ala Leu His Thr Arg Arg Thr Phe Phe Pro His Arg Thr Glu Leu
            1150                1155                1160

 ctg gag gac agg gac ctg gac caa gtg gcc tcc att gtc ctc tgg gag     3675
 Leu Glu Asp Arg Asp Leu Asp Gln Val Ala Ser Ile Val Leu Trp Glu
        1165                1170                1175

 ctt tct gac act ctc cac ggg cct gtg agg atg ccc atg agc tac cgc     3723
 Leu Ser Asp Thr Leu His Gly Pro Val Arg Met Pro Met Ser Tyr Arg
    1180                1185                1190

 tgt aca gtt ctc ggc ccc ggc ttt ctt cca aga gtt gac cag gaa ccc     3771
 Cys Thr Val Leu Gly Pro Gly Phe Leu Pro Arg Val Asp Gln Glu Pro
1195                1200                1205                1210

 taa                                                                 3774
 






      <210> 29
      <211> 2704
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1839)

      <400> 29
  atg aag gtg gtc acc cag gaa cag gac aat caa ggt tca gta act gga      48
  Met Lys Val Val Thr Gln Glu Gln Asp Asn Gln Gly Ser Val Thr Gly
    1               5                  10                  15

 gca gcg acg ttt gct att tat ctc ccg ctg gcc acg acg ggg cac cag       96
 Ala Ala Thr Phe Ala Ile Tyr Leu Pro Leu Ala Thr Thr Gly His Gln
              20                  25                  30

 aga aaa aca cag gct ccc tac gcg ctg aag gag gct tgg ccc ttg cga      144
 Arg Lys Thr Gln Ala Pro Tyr Ala Leu Lys Glu Ala Trp Pro Leu Arg
          35                  40                  45

 cgc tcc gtc gtc ggg ctc gtt gcc ggt gca aac agg gag gaa aca gcc      192
 Arg Ser Val Val Gly Leu Val Ala Gly Ala Asn Arg Glu Glu Thr Ala
      50                  55                  60

 ggc gtt gct gta gcg cgt ctg gga att aca ccg ggg gac tgg ccg gcc      240
 Gly Val Ala Val Ala Arg Leu Gly Ile Thr Pro Gly Asp Trp Pro Ala
  65                  70                  75                  80

 cgc ttc gtg cct gcg gga agt cgg gcc ggg gga ctc ttc gga aac tcc      288
 Arg Phe Val Pro Ala Gly Ser Arg Ala Gly Gly Leu Phe Gly Asn Ser
                  85                  90                  95

 gag cct cag aga aat atg gcg ctc ccg acg ctg ccg tcc tac tgg tgc      336
 Glu Pro Gln Arg Asn Met Ala Leu Pro Thr Leu Pro Ser Tyr Trp Cys
             100                 105                 110

 agc cag cag cgc ctg aat cag cag cta gca cga cag cga gag cag gag      384
 Ser Gln Gln Arg Leu Asn Gln Gln Leu Ala Arg Gln Arg Glu Gln Glu
         115                 120                 125

 gcc cgg ctt cgg cag cag tgg gag cag aac agc cgt tac ttc agg atg      432
 Ala Arg Leu Arg Gln Gln Trp Glu Gln Asn Ser Arg Tyr Phe Arg Met
     130                 135                 140

 tct gac atc tgc agc tcc aaa cag gca gaa tgg agc tct aaa acc tcc      480
 Ser Asp Ile Cys Ser Ser Lys Gln Ala Glu Trp Ser Ser Lys Thr Ser
 145                 150                 155                 160

 tac cag cgg agc atg cat gcc tat cag cgg gag aag atg aag gag gag      528
 Tyr Gln Arg Ser Met His Ala Tyr Gln Arg Glu Lys Met Lys Glu Glu
                 165                 170                 175

 aag agg agg agt ctg gag gcc cga cgg gaa aag ctc agg cag ctc atg      576
 Lys Arg Arg Ser Leu Glu Ala Arg Arg Glu Lys Leu Arg Gln Leu Met
             180                 185                 190

 cag gag gag cag gac ctg ctg gcc aga gaa ctg gag gag ctg agg ctg      624
 Gln Glu Glu Gln Asp Leu Leu Ala Arg Glu Leu Glu Glu Leu Arg Leu
         195                 200                 205

 agc atg aac ttg cag gaa aga aga atc cgg gag cag cac ggg aag ctg      672
 Ser Met Asn Leu Gln Glu Arg Arg Ile Arg Glu Gln His Gly Lys Leu
     210                 215                 220

 aaa tca gcc aaa gaa gag cag agg aaa ctg att gct gaa caa ctt ttg      720
 Lys Ser Ala Lys Glu Glu Gln Arg Lys Leu Ile Ala Glu Gln Leu Leu
 225                 230                 235                 240

 tac gaa cac tgg aaa aag aac aac ccg aaa ctt cga gag atg gag ctg      768
 Tyr Glu His Trp Lys Lys Asn Asn Pro Lys Leu Arg Glu Met Glu Leu
                 245                 250                 255

 gac ctt cac cag aag cat gtc gta aac tct tgg gaa atg cag aaa gaa      816
 Asp Leu His Gln Lys His Val Val Asn Ser Trp Glu Met Gln Lys Glu
             260                 265                 270

 gaa aaa aaa cag caa gaa gcc acc gca gag caa gag aac aaa cgg tat      864
 Glu Lys Lys Gln Gln Glu Ala Thr Ala Glu Gln Glu Asn Lys Arg Tyr
         275                 280                 285

 gaa aat gaa tat gaa agg gcc cga agg gag gcg cta gaa agg atg aaa      912
 Glu Asn Glu Tyr Glu Arg Ala Arg Arg Glu Ala Leu Glu Arg Met Lys
     290                 295                 300

 gct gaa gag gag agg agg cag ctg gag gac aag ctc cag gcc gag gca      960
 Ala Glu Glu Glu Arg Arg Gln Leu Glu Asp Lys Leu Gln Ala Glu Ala
 305                 310                 315                 320

 ctg ctg caa cag atg gag gag ctg aag ctg aag gag gtg gag gcg acc     1008
 Leu Leu Gln Gln Met Glu Glu Leu Lys Leu Lys Glu Val Glu Ala Thr
                 325                 330                 335

 aaa cta aag aag gag cag gag aat ctg ttg aag cag cgg tgg gag cta     1056
 Lys Leu Lys Lys Glu Gln Glu Asn Leu Leu Lys Gln Arg Trp Glu Leu
             340                 345                 350

 gag agg ctg gag gaa gag cga aag cag atg gaa gcc ttc cgg cag aag     1104
 Glu Arg Leu Glu Glu Glu Arg Lys Gln Met Glu Ala Phe Arg Gln Lys
         355                 360                 365

 gca gag ctg ggg cgt ttc ttg aga cat cag tat aac gct caa ctc agc     1152
 Ala Glu Leu Gly Arg Phe Leu Arg His Gln Tyr Asn Ala Gln Leu Ser
     370                 375                 380

 aga cgc aca cag cag atc caa gag gag ctg gag gca gac agg cgg atc     1200
 Arg Arg Thr Gln Gln Ile Gln Glu Glu Leu Glu Ala Asp Arg Arg Ile
 385                 390                 395                 400

 ctg cag gcc ctc ctc gag aag gag gac gag agc cag cgc ctc cac ctg     1248
 Leu Gln Ala Leu Leu Glu Lys Glu Asp Glu Ser Gln Arg Leu His Leu
                 405                 410                 415

 gcc agg cgg gag cag gtc atg gcc gat gtg gcc tgg atg aag cag gcc     1296
 Ala Arg Arg Glu Gln Val Met Ala Asp Val Ala Trp Met Lys Gln Ala
             420                 425                 430

 att gag gag cag ctg cag ctg gag cgg gcg cgg gag gca gag ctg cag     1344
 Ile Glu Glu Gln Leu Gln Leu Glu Arg Ala Arg Glu Ala Glu Leu Gln
         435                 440                 445

 atg ctg ctg agg gag gag gcc aag gag atg tgg gaa aag aga gag gca     1392
 Met Leu Leu Arg Glu Glu Ala Lys Glu Met Trp Glu Lys Arg Glu Ala
     450                 455                 460

 gag tgg gcc cga gag cgc agc gca cgg gac aga ctg atg agc gag gtt     1440
 Glu Trp Ala Arg Glu Arg Ser Ala Arg Asp Arg Leu Met Ser Glu Val
 465                 470                 475                 480

 ctg aca ggg aga caa cag caa ata caa gag aag att gag cag aac cga     1488
 Leu Thr Gly Arg Gln Gln Gln Ile Gln Glu Lys Ile Glu Gln Asn Arg
                 485                 490                 495

 cgg gca caa gag gaa tcc ctg aaa cac agg gag caa ctt att cga aat     1536
 Arg Ala Gln Glu Glu Ser Leu Lys His Arg Glu Gln Leu Ile Arg Asn
             500                 505                 510

 ctt gag gag gtg aga gag ttg gct cgt cgc gag aaa gag gag agt gaa     1584
 Leu Glu Glu Val Arg Glu Leu Ala Arg Arg Glu Lys Glu Glu Ser Glu
         515                 520                 525

 aag ctg aaa tcg gcc agg aag cag gag ctg gaa gcc cag gtt gca gag     1632
 Lys Leu Lys Ser Ala Arg Lys Gln Glu Leu Glu Ala Gln Val Ala Glu
     530                 535                 540

 cgc cgg ctg cag gca tgg gaa gca gac cag cag gag gag gag gaa gag     1680
 Arg Arg Leu Gln Ala Trp Glu Ala Asp Gln Gln Glu Glu Glu Glu Glu
 545                 550                 555                 560

 gag gag gcc cgg cgg gtc gag cag ctc tca gat gcc ctg ctg cag cag     1728
 Glu Glu Ala Arg Arg Val Glu Gln Leu Ser Asp Ala Leu Leu Gln Gln
                 565                 570                 575

 gag gcg gag act atg gct gag cag ggc tac cgg cct agc ctt acg gac     1776
 Glu Ala Glu Thr Met Ala Glu Gln Gly Tyr Arg Pro Ser Leu Thr Asp
             580                 585                 590

 atc caa aaa ttg ctt gga act gac ttc atg ggt acc ata agt aca gag     1824
 Ile Gln Lys Leu Leu Gly Thr Asp Phe Met Gly Thr Ile Ser Thr Glu
         595                 600                 605

 aac aag gga tgc tga ggcttctgat cccagccgcc aggcagtttt acagggctct     1879
 Asn Lys Gly Cys 
     610

 gttaacagta agtgcccggg gcactgtcag atggctcagc agtgcctgct caggttcatc   1939

 attgaaacat cccagtgttt ggccagacat taaggtgtcg tgagagtccc tttcatgcct   1999

 ttcttaccca agcaagggtc tttgatgggc acgtgtttac agcgctgctg catagtcttg   2059

 taatatatta acagtcacat caactgaagg tcaatactaa gagccacagg ttgtacctgt   2119

 gatggggcgt gtggtttcct gttgtctcac ctttaattgt caacctccag tgttgactct   2179

 agaaatatga ggaaagcttt tcagttttta aaattgccat ttaaatttag tctattaaaa   2239

 acaaacctag aggtcttggt gcagttgatt tcagagttta ttaatttagt ggtcccaaaa   2299

 gtattacatc ttttatattc tggaagaaaa gaactgtgaa caaattagaa ccccggaaca   2359

 ctctgacgtc catggacgca ttccagaaaa gtggcaagag atgagtcttt cctcctccag   2419

 gaagcatttt ggtagaattt ccatagagca ttgtctgtga gtgactgatc ccaacatgta   2479

 tgttactaag ccccaaaacg aacttcaaac tgcgttgtgg tggccgtgct taagtcccaa   2539

 gctaaccgcg aggtgcgcca gaaggattgt tgagcccagg aattcagagt ccaactggaa   2599

 aaagtgagac ccttttaaac caaaaggtct ttagaaggcc ctggtggcaa ccttaaaacc   2659

 agggggcacg tagaccttgg atgtcgtgta actgcttcgg gtatg                   2704




      <210> 30
      <211> 1668
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1668)

      <400> 30
  atg ctg aga gag aag ttt cct gag ttc tgc agc tca ccc tcc cca cct      48
  Met Leu Arg Glu Lys Phe Pro Glu Phe Cys Ser Ser Pro Ser Pro Pro
    1               5                  10                  15

 gtg gaa gtc aaa att gag gag cca gtt tcc atg gag atg gac aac cat       96
 Val Glu Val Lys Ile Glu Glu Pro Val Ser Met Glu Met Asp Asn His
              20                  25                  30

 atg tcg gat aag gat gag agt tgc tat gac aat gca gag gca gcc ttc      144
 Met Ser Asp Lys Asp Glu Ser Cys Tyr Asp Asn Ala Glu Ala Ala Phe
          35                  40                  45

 agt gac gat gaa gag gat ctc aac agc aaa gga aag aag agg gag ttt      192
 Ser Asp Asp Glu Glu Asp Leu Asn Ser Lys Gly Lys Lys Arg Glu Phe
      50                  55                  60

 cgc ttc cac cct atc aag gag aca gtt gtg gag gag cca gtt gat atc      240
 Arg Phe His Pro Ile Lys Glu Thr Val Val Glu Glu Pro Val Asp Ile
  65                  70                  75                  80

 acc cct tac ctt gac cag ttg gat gag tcc ctg agg gac aaa gta ctc      288
 Thr Pro Tyr Leu Asp Gln Leu Asp Glu Ser Leu Arg Asp Lys Val Leu
                  85                  90                  95

 cag cta cag aag ggg agt gat acg gag gcc cag tgt gag gtc atg cag      336
 Gln Leu Gln Lys Gly Ser Asp Thr Glu Ala Gln Cys Glu Val Met Gln
             100                 105                 110

 gaa att gtg gac cag gtc ctg gag gaa gac ttt gac tcg gag cag ctg      384
 Glu Ile Val Asp Gln Val Leu Glu Glu Asp Phe Asp Ser Glu Gln Leu
         115                 120                 125

 tct gtc ctt gct tcc tgc cta cag gag ctc ttc aag gcc cac ttt cga      432
 Ser Val Leu Ala Ser Cys Leu Gln Glu Leu Phe Lys Ala His Phe Arg
     130                 135                 140

 ggg gag gtc ctg cct gag gag att act gag gag tcc ctg gag gag tct      480
 Gly Glu Val Leu Pro Glu Glu Ile Thr Glu Glu Ser Leu Glu Glu Ser
 145                 150                 155                 160

 gta gga aag cct ctg tac cta ata ttt agg aac cta tgt cag atg cag      528
 Val Gly Lys Pro Leu Tyr Leu Ile Phe Arg Asn Leu Cys Gln Met Gln
                 165                 170                 175

 gaa gac aac agc agc ttc tct cta ctt cta gac ctt ctc tcc gag cta      576
 Glu Asp Asn Ser Ser Phe Ser Leu Leu Leu Asp Leu Leu Ser Glu Leu
             180                 185                 190

 tat cag aag cag ccc aag att ggc tac cac ctg ctc tac tac ctg agg      624
 Tyr Gln Lys Gln Pro Lys Ile Gly Tyr His Leu Leu Tyr Tyr Leu Arg
         195                 200                 205

 gcc agc aaa gcc gcc gca ggg aag atg aac ctg tac gag tca ttt gcc      672
 Ala Ser Lys Ala Ala Ala Gly Lys Met Asn Leu Tyr Glu Ser Phe Ala
     210                 215                 220

 cag gct acc cag ctg ggc gat ctg cac acc tgc ctg atg atg gac atg      720
 Gln Ala Thr Gln Leu Gly Asp Leu His Thr Cys Leu Met Met Asp Met
 225                 230                 235                 240

 aag gcc tgc cag gag gac gat gtg cgg ctc ctg tgc cac ctc acg ccc      768
 Lys Ala Cys Gln Glu Asp Asp Val Arg Leu Leu Cys His Leu Thr Pro
                 245                 250                 255

 tcc atc tac aca gag ttt cca gat gaa acc ttg agg agc gga gag ctg      816
 Ser Ile Tyr Thr Glu Phe Pro Asp Glu Thr Leu Arg Ser Gly Glu Leu
             260                 265                 270

 ctg aac atg atc gtg gct gtt att gac tct gca cag ctc cag gag ctg      864
 Leu Asn Met Ile Val Ala Val Ile Asp Ser Ala Gln Leu Gln Glu Leu
         275                 280                 285

 gtc tgc cac gtg atg atg ggt aac ctg gtt atg ttt cga aaa gac tca      912
 Val Cys His Val Met Met Gly Asn Leu Val Met Phe Arg Lys Asp Ser
     290                 295                 300

 gtt ctc aac ata ctc att cag agc cta gac tgg gag acc ttt gag cag      960
 Val Leu Asn Ile Leu Ile Gln Ser Leu Asp Trp Glu Thr Phe Glu Gln
 305                 310                 315                 320

 tat tgt gcc tgg cag ctc ttt ctg gcc cac aat att ccc ctg gag acc     1008
 Tyr Cys Ala Trp Gln Leu Phe Leu Ala His Asn Ile Pro Leu Glu Thr
                 325                 330                 335

 ata atc ccc atc ctg cag cac ctc aaa tac aag gag cac cca gag gcc     1056
 Ile Ile Pro Ile Leu Gln His Leu Lys Tyr Lys Glu His Pro Glu Ala
             340                 345                 350

 ctg tcc tgc cta ctg ctt caa ctc cga aga gaa aag ccc agc gag gag     1104
 Leu Ser Cys Leu Leu Leu Gln Leu Arg Arg Glu Lys Pro Ser Glu Glu
         355                 360                 365

 atg gtg aag atg gtg ctg agc cgg ccc tgc cat cct gac gac cag ttc     1152
 Met Val Lys Met Val Leu Ser Arg Pro Cys His Pro Asp Asp Gln Phe
     370                 375                 380

 acc acc agc atc ctg cgg cac tgg tgc atg aaa cat gac gag ctg ctg     1200
 Thr Thr Ser Ile Leu Arg His Trp Cys Met Lys His Asp Glu Leu Leu
 385                 390                 395                 400

 gcc gag cac atc aag tcc ctg ctc atc aag aac aac agc ctg cct cgc     1248
 Ala Glu His Ile Lys Ser Leu Leu Ile Lys Asn Asn Ser Leu Pro Arg
                 405                 410                 415

 aag aga cag agc ctg agg agc tct agc agc aag ctg gcc cag ctg act     1296
 Lys Arg Gln Ser Leu Arg Ser Ser Ser Ser Lys Leu Ala Gln Leu Thr
             420                 425                 430

 ctg gag cag atc ctg gag cac ttg gac aat ctg cgg ctc aac ctg acc     1344
 Leu Glu Gln Ile Leu Glu His Leu Asp Asn Leu Arg Leu Asn Leu Thr
         435                 440                 445

 aac acc aag cag aac ttt ttt agc cag acg cca att ctc cag gcg ctg     1392
 Asn Thr Lys Gln Asn Phe Phe Ser Gln Thr Pro Ile Leu Gln Ala Leu
     450                 455                 460

 cag cat gtc caa gcg agc tgt gac gaa gcc cac aag atg aaa ttc agt     1440
 Gln His Val Gln Ala Ser Cys Asp Glu Ala His Lys Met Lys Phe Ser
 465                 470                 475                 480

 gat ctc ttc tcc ctg gcg gag gaa tat gag gac tct tcc acc aag cca     1488
 Asp Leu Phe Ser Leu Ala Glu Glu Tyr Glu Asp Ser Ser Thr Lys Pro
                 485                 490                 495

 ccc aag agc cgg cga aaa gca gct ctg tcc agc cct cga agt cga aag     1536
 Pro Lys Ser Arg Arg Lys Ala Ala Leu Ser Ser Pro Arg Ser Arg Lys
             500                 505                 510

 aat gcc aca cag ccc ccc aat gcc gaa gaa gag tcg ggc tcc agc agt     1584
 Asn Ala Thr Gln Pro Pro Asn Ala Glu Glu Glu Ser Gly Ser Ser Ser
         515                 520                 525

 gct tca gaa gag gaa gac acg aaa ccg aag cct acc aag cgg aaa cga     1632
 Ala Ser Glu Glu Glu Asp Thr Lys Pro Lys Pro Thr Lys Arg Lys Arg
     530                 535                 540

 aaa ggg tcc tct gca gtg ggc tct gac agt gac tga                     1668
 Lys Gly Ser Ser Ala Val Gly Ser Asp Ser Asp 
 545                 550                 555





      <210> 31
      <211> 1770
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1770)

      <400> 31
  atg tct tct tgg ctc tta gag gaa ttt ctc tcc tgc cat cgt att aca      48
  Met Ser Ser Trp Leu Leu Glu Glu Phe Leu Ser Cys His Arg Ile Thr
    1               5                  10                  15

 aaa cac cta gct ccc ctg ttt gac aac cct aag ttg gat aag gag ctg       96
 Lys His Leu Ala Pro Leu Phe Asp Asn Pro Lys Leu Asp Lys Glu Leu
              20                  25                  30

 cgg gca atg ctg aga gag aag ttt cct gag ttc tgc agc tca ccc tcc      144
 Arg Ala Met Leu Arg Glu Lys Phe Pro Glu Phe Cys Ser Ser Pro Ser
          35                  40                  45

 cca cct gtg gaa gtc aaa att gag gag cca gtt tcc atg gag atg gac      192
 Pro Pro Val Glu Val Lys Ile Glu Glu Pro Val Ser Met Glu Met Asp
      50                  55                  60

 aac cat atg tcg gat aag gat gag agt tgc tat gac aat gca gag gca      240
 Asn His Met Ser Asp Lys Asp Glu Ser Cys Tyr Asp Asn Ala Glu Ala
  65                  70                  75                  80

 gcc ttc agt gac gat gaa gag gat ctc aac agc aaa gga aag aag agg      288
 Ala Phe Ser Asp Asp Glu Glu Asp Leu Asn Ser Lys Gly Lys Lys Arg
                  85                  90                  95

 gag ttt cgc ttc cac cct atc aag gag aca gtt gtg gag gag cca gtt      336
 Glu Phe Arg Phe His Pro Ile Lys Glu Thr Val Val Glu Glu Pro Val
             100                 105                 110

 gat atc acc cct tac ctt gac cag ttg gat gag tcc ctg agg gac aaa      384
 Asp Ile Thr Pro Tyr Leu Asp Gln Leu Asp Glu Ser Leu Arg Asp Lys
         115                 120                 125

 gta ctc cag cta cag aag ggg agt gat acg gag gcc cag tgt gag gtc      432
 Val Leu Gln Leu Gln Lys Gly Ser Asp Thr Glu Ala Gln Cys Glu Val
     130                 135                 140

 atg cag gaa att gtg gac cag gtc ctg gag gaa gac ttt gac tcg gag      480
 Met Gln Glu Ile Val Asp Gln Val Leu Glu Glu Asp Phe Asp Ser Glu
 145                 150                 155                 160

 cag ctg tct gtc ctt gct tcc tgc cta cag gag ctc ttc aag gcc cac      528
 Gln Leu Ser Val Leu Ala Ser Cys Leu Gln Glu Leu Phe Lys Ala His
                 165                 170                 175

 ttt cga ggg gag gtc ctg cct gag gag att act gag gag tcc ctg gag      576
 Phe Arg Gly Glu Val Leu Pro Glu Glu Ile Thr Glu Glu Ser Leu Glu
             180                 185                 190

 gag tct gta gga aag cct ctg tac cta ata ttt agg aac cta tgt cag      624
 Glu Ser Val Gly Lys Pro Leu Tyr Leu Ile Phe Arg Asn Leu Cys Gln
         195                 200                 205

 atg cag gaa gac aac agc agc ttc tct cta ctt cta gac ctt ctc tcc      672
 Met Gln Glu Asp Asn Ser Ser Phe Ser Leu Leu Leu Asp Leu Leu Ser
     210                 215                 220

 gag cta tat cag aag cag ccc aag att ggc tac cac ctg ctc tac tac      720
 Glu Leu Tyr Gln Lys Gln Pro Lys Ile Gly Tyr His Leu Leu Tyr Tyr
 225                 230                 235                 240

 ctg agg gcc agc aaa gcc gcc gca ggg aag atg aac ctg tac gag tca      768
 Leu Arg Ala Ser Lys Ala Ala Ala Gly Lys Met Asn Leu Tyr Glu Ser
                 245                 250                 255

 ttt gcc cag gct acc cag ctg ggc gat ctg cac acc tgc ctg atg atg      816
 Phe Ala Gln Ala Thr Gln Leu Gly Asp Leu His Thr Cys Leu Met Met
             260                 265                 270

 gac atg aag gcc tgc cag gag gac gat gtg cgg ctc ctg tgc cac ctc      864
 Asp Met Lys Ala Cys Gln Glu Asp Asp Val Arg Leu Leu Cys His Leu
         275                 280                 285

 acg ccc tcc atc tac aca gag ttt cca gat gaa acc ttg agg agc gga      912
 Thr Pro Ser Ile Tyr Thr Glu Phe Pro Asp Glu Thr Leu Arg Ser Gly
     290                 295                 300

 gag ctg ctg aac atg atc gtg gct gtt att gac tct gca cag ctc cag      960
 Glu Leu Leu Asn Met Ile Val Ala Val Ile Asp Ser Ala Gln Leu Gln
 305                 310                 315                 320

 gag ctg gtc tgc cac gtg atg atg ggt aac ctg gtt atg ttt cga aaa     1008
 Glu Leu Val Cys His Val Met Met Gly Asn Leu Val Met Phe Arg Lys
                 325                 330                 335

 gac tca gtt ctc aac ata ctc att cag agc cta gac tgg gag acc ttt     1056
 Asp Ser Val Leu Asn Ile Leu Ile Gln Ser Leu Asp Trp Glu Thr Phe
             340                 345                 350

 gag cag tat tgt gcc tgg cag ctc ttt ctg gcc cac aat att ccc ctg     1104
 Glu Gln Tyr Cys Ala Trp Gln Leu Phe Leu Ala His Asn Ile Pro Leu
         355                 360                 365

 gag acc ata atc ccc atc ctg cag cac ctc aaa tac aag gag cac cca     1152
 Glu Thr Ile Ile Pro Ile Leu Gln His Leu Lys Tyr Lys Glu His Pro
     370                 375                 380

 gag gcc ctg tcc tgc cta ctg ctt caa ctc cga aga gaa aag ccc agc     1200
 Glu Ala Leu Ser Cys Leu Leu Leu Gln Leu Arg Arg Glu Lys Pro Ser
 385                 390                 395                 400

 gag gag atg gtg aag atg gtg ctg agc cgg ccc tgc cat cct gac gac     1248
 Glu Glu Met Val Lys Met Val Leu Ser Arg Pro Cys His Pro Asp Asp
                 405                 410                 415

 cag ttc acc acc agc atc ctg cgg cac tgg tgc atg aaa cat gac gag     1296
 Gln Phe Thr Thr Ser Ile Leu Arg His Trp Cys Met Lys His Asp Glu
             420                 425                 430

 ctg ctg gcc gag cac atc aag tcc ctg ctc atc aag aac aac agc ctg     1344
 Leu Leu Ala Glu His Ile Lys Ser Leu Leu Ile Lys Asn Asn Ser Leu
         435                 440                 445

 cct cgc aag aga cag agc ctg agg agc tct agc agc aag ctg gcc cag     1392
 Pro Arg Lys Arg Gln Ser Leu Arg Ser Ser Ser Ser Lys Leu Ala Gln
     450                 455                 460

 ctg act ctg gag cag atc ctg gag cac ttg gac aat ctg cgg ctc aac     1440
 Leu Thr Leu Glu Gln Ile Leu Glu His Leu Asp Asn Leu Arg Leu Asn
 465                 470                 475                 480

 ctg acc aac acc aag cag aac ttt ttt agc cag acg cca att ctc cag     1488
 Leu Thr Asn Thr Lys Gln Asn Phe Phe Ser Gln Thr Pro Ile Leu Gln
                 485                 490                 495

 gcg ctg cag cat gtc caa gcg agc tgt gac gaa gcc cac aag atg aaa     1536
 Ala Leu Gln His Val Gln Ala Ser Cys Asp Glu Ala His Lys Met Lys
             500                 505                 510

 ttc agt gat ctc ttc tcc ctg gcg gag gaa tat gag gac tct tcc acc     1584
 Phe Ser Asp Leu Phe Ser Leu Ala Glu Glu Tyr Glu Asp Ser Ser Thr
         515                 520                 525

 aag cca ccc aag agc cgg cga aaa gca gct ctg tcc agc cct cga agt     1632
 Lys Pro Pro Lys Ser Arg Arg Lys Ala Ala Leu Ser Ser Pro Arg Ser
     530                 535                 540

 cga aag aat gcc aca cag ccc ccc aat gcc gaa gaa gag tcg ggc tcc     1680
 Arg Lys Asn Ala Thr Gln Pro Pro Asn Ala Glu Glu Glu Ser Gly Ser
 545                 550                 555                 560

 agc agt gct tca gaa gag gaa gac acg aaa ccg aag cct acc aag cgg     1728
 Ser Ser Ala Ser Glu Glu Glu Asp Thr Lys Pro Lys Pro Thr Lys Arg
                 565                 570                 575

 aaa cga aaa ggg tcc tct gca gtg ggc tct gac agt gac tga             1770
 Lys Arg Lys Gly Ser Ser Ala Val Gly Ser Asp Ser Asp 
             580                 585





      <210> 32
      <211> 297
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(297)

      <400> 32
  atg gga aaa aag tgg ggt tgg cag gaa atg gaa aac gga ggt gcc gcc      48
  Met Gly Lys Lys Trp Gly Trp Gln Glu Met Glu Asn Gly Gly Ala Ala
    1               5                  10                  15

 cca gca tgg ggg gca ggt ccc cca gtc cac cct gcc cct ccc cct gtg       96
 Pro Ala Trp Gly Ala Gly Pro Pro Val His Pro Ala Pro Pro Pro Val
              20                  25                  30

 gag aag acg ctt agt tgg ggg tgt ggg ttt ggg ctc cat tct gga ttc      144
 Glu Lys Thr Leu Ser Trp Gly Cys Gly Phe Gly Leu His Ser Gly Phe
          35                  40                  45

 ggc ggt tcc ggg gga ggg gtg ggt ctg tgc cga tta ctc tgt ctt gta      192
 Gly Gly Ser Gly Gly Gly Val Gly Leu Cys Arg Leu Leu Cys Leu Val
      50                  55                  60

 cgt ttg ttc tgc tgc tct tca ata ttg tat caa cgc cag gaa agg ggg      240
 Arg Leu Phe Cys Cys Ser Ser Ile Leu Tyr Gln Arg Gln Glu Arg Gly
  65                  70                  75                  80

 gtg aaa agc ctc ttt tac ccc cca aat aaa ttg tca cat tcc gaa gct      288
 Val Lys Ser Leu Phe Tyr Pro Pro Asn Lys Leu Ser His Ser Glu Ala
                  85                  90                  95

 gag gcc tag                                                          297
 Glu Ala 






      <210> 33
      <211> 1437
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1437)

      <400> 33
  atg ttg cca gac tgg aca gca ttg cca ctg cca tgt gca tcc gcc cat      48
  Met Leu Pro Asp Trp Thr Ala Leu Pro Leu Pro Cys Ala Ser Ala His
    1               5                  10                  15

 gtg cca tgt gaa tca tgt tgg act gcc cag tgt gca gac gga gtg ccc       96
 Val Pro Cys Glu Ser Cys Trp Thr Ala Gln Cys Ala Asp Gly Val Pro
              20                  25                  30

 ccg tgc ctt gtc agc gtg cag ccc cac gtc cca gta ctg aca tac cca      144
 Pro Cys Leu Val Ser Val Gln Pro His Val Pro Val Leu Thr Tyr Pro
          35                  40                  45

 gtg ctc gca gcc ttt ctt cgg aga gtg gag gcc atg gtc atc cga gag      192
 Val Leu Ala Ala Phe Leu Arg Arg Val Glu Ala Met Val Ile Arg Glu
      50                  55                  60

 ctg aac aag aat tgg cag agc cac gcg ttt gat ggc ttc gag gtg aac      240
 Leu Asn Lys Asn Trp Gln Ser His Ala Phe Asp Gly Phe Glu Val Asn
  65                  70                  75                  80

 tgg acc gag cag cag cag atg gtg tct tgt ctg tat acc ctg ggc tac      288
 Trp Thr Glu Gln Gln Gln Met Val Ser Cys Leu Tyr Thr Leu Gly Tyr
                  85                  90                  95

 ccg cca gcc caa gcg cag ggt ctg cat gtg acc agc atc tcc tgg aac      336
 Pro Pro Ala Gln Ala Gln Gly Leu His Val Thr Ser Ile Ser Trp Asn
             100                 105                 110

 tcc act ggc tct gtg gtg gcc tgt gcc tac ggc cgg ctg gac cat ggg      384
 Ser Thr Gly Ser Val Val Ala Cys Ala Tyr Gly Arg Leu Asp His Gly
         115                 120                 125

 gac tgg agc acg ctt aag tcc ttc gtg tgt gcc tgg aac ctg gac cgg      432
 Asp Trp Ser Thr Leu Lys Ser Phe Val Cys Ala Trp Asn Leu Asp Arg
     130                 135                 140

 cga gac ctg cgt ccc cag caa ccg tcg gcc gtg gtg gag gtc ccc agc      480
 Arg Asp Leu Arg Pro Gln Gln Pro Ser Ala Val Val Glu Val Pro Ser
 145                 150                 155                 160

 gct gtc ctg tgt ctg gcc ttc cac ccc acg cag ccc tcc cac gtc gca      528
 Ala Val Leu Cys Leu Ala Phe His Pro Thr Gln Pro Ser His Val Ala
                 165                 170                 175

 gga ggg ctg tac agt ggt gag gtg ttg gtg tgg gac ctg agc cgt ctt      576
 Gly Gly Leu Tyr Ser Gly Glu Val Leu Val Trp Asp Leu Ser Arg Leu
             180                 185                 190

 gag gac ccg ctg ctg tgg cgc aca ggc ctg acg gat gac acc cac aca      624
 Glu Asp Pro Leu Leu Trp Arg Thr Gly Leu Thr Asp Asp Thr His Thr
         195                 200                 205

 gac cct gtg tcc cag gtg gtg tgg ctg ccc gag cct ggg cac agc cac      672
 Asp Pro Val Ser Gln Val Val Trp Leu Pro Glu Pro Gly His Ser His
     210                 215                 220

 cgc ttc cag gtg ctg agt gtg gcc act gac ggg aag gtg cta ctc tgg      720
 Arg Phe Gln Val Leu Ser Val Ala Thr Asp Gly Lys Val Leu Leu Trp
 225                 230                 235                 240

 cag ggc atc ggg gta ggc cag ctg cag ctc aca gag ggc ttc gcc ctg      768
 Gln Gly Ile Gly Val Gly Gln Leu Gln Leu Thr Glu Gly Phe Ala Leu
                 245                 250                 255

 gtc atg cag cag ctg cca cgg agc acc aag ctc aag aag cat ccc cgc      816
 Val Met Gln Gln Leu Pro Arg Ser Thr Lys Leu Lys Lys His Pro Arg
             260                 265                 270

 ggg gag acc gag gtg ggc gcc acg gca gtg gcc ttc tcc agc ttt gac      864
 Gly Glu Thr Glu Val Gly Ala Thr Ala Val Ala Phe Ser Ser Phe Asp
         275                 280                 285

 cct agg ctg ttc att ctg ggc acg gaa ggc ggc ttc ccg ctc aag tgt      912
 Pro Arg Leu Phe Ile Leu Gly Thr Glu Gly Gly Phe Pro Leu Lys Cys
     290                 295                 300

 tcc ctg gca gct gga gag gca gcc ctc acg cgg atg ccc agc tcc gtg      960
 Ser Leu Ala Ala Gly Glu Ala Ala Leu Thr Arg Met Pro Ser Ser Val
 305                 310                 315                 320

 ccc ctg cgg gcc cca gca cag ttt acc ttc tcc ccc cac ggc ggt ccc     1008
 Pro Leu Arg Ala Pro Ala Gln Phe Thr Phe Ser Pro His Gly Gly Pro
                 325                 330                 335

 atc tac tct gtg agc tgt tcc ccc ttc cac agg aat ctc ttc ctg agc     1056
 Ile Tyr Ser Val Ser Cys Ser Pro Phe His Arg Asn Leu Phe Leu Ser
             340                 345                 350

 gct ggg act gac ggg cat gtc cac ctg tac tcc atg ctg cag gcc cct     1104
 Ala Gly Thr Asp Gly His Val His Leu Tyr Ser Met Leu Gln Ala Pro
         355                 360                 365

 ccc ttg act tcg ctg cag ctc tcc ctc aag tat ctg ttt gct gtg cgc     1152
 Pro Leu Thr Ser Leu Gln Leu Ser Leu Lys Tyr Leu Phe Ala Val Arg
     370                 375                 380

 tgg tcc cca gtg cgg ccc ttg gtt ttt gca gct gcc tct ggg aaa ggt     1200
 Trp Ser Pro Val Arg Pro Leu Val Phe Ala Ala Ala Ser Gly Lys Gly
 385                 390                 395                 400

 gac gtg cag ctg ttt gat ctc cag aaa agc tcc cag aaa ccc aca gtt     1248
 Asp Val Gln Leu Phe Asp Leu Gln Lys Ser Ser Gln Lys Pro Thr Val
                 405                 410                 415

 ttg atc aag caa acc cag gat gaa agc cct gtc tac tgt ctg gag ttc     1296
 Leu Ile Lys Gln Thr Gln Asp Glu Ser Pro Val Tyr Cys Leu Glu Phe
             420                 425                 430

 aac agc cag cag act cag ctc ttg gct gcg ggc gat gcc cag ggc aca     1344
 Asn Ser Gln Gln Thr Gln Leu Leu Ala Ala Gly Asp Ala Gln Gly Thr
         435                 440                 445

 gtg aag gtg tgg cag ctg agc aca gag ttc acg gaa caa ggg ccc cgg     1392
 Val Lys Val Trp Gln Leu Ser Thr Glu Phe Thr Glu Gln Gly Pro Arg
     450                 455                 460

 gaa gct gag gac ctg gac tgc ctg gca gca gag gtg gcg gcc tga         1437
 Glu Ala Glu Asp Leu Asp Cys Leu Ala Ala Glu Val Ala Ala 
 465                 470                 475





      <210> 34
      <211> 632
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (76)..(570)

      <400> 34
 cagaggaaga agacaaccca tagccacctc cactgggttc gactccagct ccggggctcg     60

 caggagtaaa cgcgc atg ctc agg gag ctc ggt cgc gca tgc tca gcg caa     111
                  Met Leu Arg Glu Leu Gly Arg Ala Cys Ser Ala Gln
                    1               5                  10

 cgg cgg gaa gac tcc agc cgc cag ggg gag cgc gtg ccg ttc ttg cct      159
 Arg Arg Glu Asp Ser Ser Arg Gln Gly Glu Arg Val Pro Phe Leu Pro
          15                  20                  25

 ctc tgg cct gcg cct cct gag ccg agt aga tat ccc gga gtt ccg cgc      207
 Leu Trp Pro Ala Pro Pro Glu Pro Ser Arg Tyr Pro Gly Val Pro Arg
      30                  35                  40

 ggc gcc agc cct tcc gcc acg gcc gtc tcg tgg aga gca gca gcc atg      255
 Gly Ala Ser Pro Ser Ala Thr Ala Val Ser Trp Arg Ala Ala Ala Met
  45                  50                  55                  60

 gcc cta cgc tac cct atg gcc gtg ggc ctc aac aag ggc cac aaa gtg      303
 Ala Leu Arg Tyr Pro Met Ala Val Gly Leu Asn Lys Gly His Lys Val
                  65                  70                  75

 acc aag aac gtg agc aag ccc agg cac agc cga cgc cgc ggg cgt ctg      351
 Thr Lys Asn Val Ser Lys Pro Arg His Ser Arg Arg Arg Gly Arg Leu
              80                  85                  90

 acc aaa cac acc aag ttc gtg cgg gac atg att cgg gag gtg tgt ggc      399
 Thr Lys His Thr Lys Phe Val Arg Asp Met Ile Arg Glu Val Cys Gly
          95                 100                 105

 ttt gcc ccg tac gag cgg cgc gcc atg gag tta ctg aag gtc tcc aag      447
 Phe Ala Pro Tyr Glu Arg Arg Ala Met Glu Leu Leu Lys Val Ser Lys
     110                 115                 120

 gac aaa cgg gcc ctc aaa ttt atc aag aaa agg gtg ggg acg cac atc      495
 Asp Lys Arg Ala Leu Lys Phe Ile Lys Lys Arg Val Gly Thr His Ile
 125                 130                 135                 140

 cgc gcc aag agg aag cgg gag gag ctg agc aac gta ctg gcc gcc atg      543
 Arg Ala Lys Arg Lys Arg Glu Glu Leu Ser Asn Val Leu Ala Ala Met
                 145                 150                 155

 agg aaa gct gct gcc aag aaa gac tga gcccc ttccctgccc tctccctgaa      595
 Arg Lys Ala Ala Ala Lys Lys Asp 
             160

 ataaagaaca gcttgacaga aaaaaaaaaa aaaaaaa                             632




      <210> 35
      <211> 2332
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (111)..(587)

      <400> 35
 gtcaggccga tccgctccgc tcacggaagg aaaacagaaa taacttgctg gcttgtctgg     60

 agtcacatgt acttaggtga caatttacag aaagtcatct ctgcagcttg   atg ggc     116
                                                          Met Gly
                                                            1

 gac aac cct ttt caa cca aaa agt aat tca aaa atg gca gaa ctg ttt      164
 Asp Asn Pro Phe Gln Pro Lys Ser Asn Ser Lys Met Ala Glu Leu Phe
           5                  10                  15

 atg gaa tgt gaa gaa gag gag ctg gaa cca tgg cag aag aaa gta aaa      212
 Met Glu Cys Glu Glu Glu Glu Leu Glu Pro Trp Gln Lys Lys Val Lys
      20                  25                  30

 gaa gtt gag gat gac gat gat gat gag cca atc ttt gtt ggc gag ata      260
 Glu Val Glu Asp Asp Asp Asp Asp Glu Pro Ile Phe Val Gly Glu Ile
  35                  40                  45                  50

 tca agt tca aaa cca gca att tca aat att ttg aac aga gtt aac ccc      308
 Ser Ser Ser Lys Pro Ala Ile Ser Asn Ile Leu Asn Arg Val Asn Pro
                  55                  60                  65

 agc tca tat tca agg gga cta aag aat ggt gca ctc agt cga ggt att      356
 Ser Ser Tyr Ser Arg Gly Leu Lys Asn Gly Ala Leu Ser Arg Gly Ile
              70                  75                  80

 act gct gca ttc aag cct aca agt caa cac tac acg aat cca aca tca      404
 Thr Ala Ala Phe Lys Pro Thr Ser Gln His Tyr Thr Asn Pro Thr Ser
          85                  90                  95

 aat cca gtg cct gcc tca cca ata aat ttt cat cct gag tct aga tct      452
 Asn Pro Val Pro Ala Ser Pro Ile Asn Phe His Pro Glu Ser Arg Ser
     100                 105                 110

 tca gat agt tct gtt att gtt cag cct ttt tct aaa cct gta agt gtt      500
 Ser Asp Ser Ser Val Ile Val Gln Pro Phe Ser Lys Pro Val Ser Val
 115                 120                 125                 130

 tct aaa act ata cgg cca gct cag gga tcc att gga tgt tgt tta tca      548
 Ser Lys Thr Ile Arg Pro Ala Gln Gly Ser Ile Gly Cys Cys Leu Ser
                 135                 140                 145

 ata tca aca gta ccc agt tac aat tct gga ctg tca taa gtagtcatcc       597
 Ile Ser Thr Val Pro Ser Tyr Asn Ser Gly Leu Ser 
             150                 155

 agtagaagca tagttagcat cagaaaatgt caccatattt tcgctagctc aagcagtacc    657

 ccaagtaata actgaaggag ctaactaccc aacctgttaa taacaggcag tatgcctaaa    717

 taggtacagt aatgaaaact atactatcaa aatgtgaata aaattatagt cagccataaa    777

 cattgcataa tgacaaatat ttaagattgc agacgggacc aggtattctt aattgggaaa    837

 acagtcaagt gaccatcata gctttttatt ctgaaaacat tccttcatag ttcagttagt    897

 taaaaaaaaa caaacatttt ttcctattac aaaaaactcc cacttttttt gttacaaaaa    957

 gtaatagaaa atggtaatag ttaacattca ttgagctgtt aatatgtata agtgtttgtg   1017

 ctaaatgcta taggtaaatt catttcattt agttcttaaa aatccccatg aagtaaacac   1077

 tattattatc ctcatgttta gttgaaggaa actgaggctc atagaggttg aaagatttat   1137

 tcaagatccc aaagctggca gttgatggat ctgggatttc aatccagcct aacccatagt   1197

 ttatatgtat atgcacacat acatacatat atgttgtgta taaatgtaca cttttttaga   1257

 catgaaagaa ttgccttagt tgaacagttc tcagattgta gtttgcaatc ccctggggtt   1317

 ccccaagacc ctttcagagg tttgagggtc aacagtgttg tcattataat caaagactgt   1377

 tttccttttc cactgtgttg gcatttgcac tggtgatgct aaagtaatgg tggataagct   1437

 gctggtgcct tagtgtgaat caaggtagtg ccaccaaagt gtacttgtag tttctgtatt   1497

 agtcacctgc cgtgcactca cagtaaacta cattactcaa ctgagtatta cccagttata   1557

 cccaatccct gatgaagtat taaaatgtta ttagttttat taactctcta cacttgaatg   1617

 tgtgtttttt aaaatattct gtgtgatgac atgggtagtg tgcataaagt acctctgtgt   1677

 ctgaagtatg atagttgtct tgaggaaaag cacttgtgtg attgaattgt gaggtaaact   1737

 acctgatttt tttttgttgt tacatgaaag aatgactgac aaatctttaa agtatttaca   1797

 atatcactcc agaaaagaaa acaaatcaaa taaatattga ctcaaaactc tccaagtaca   1857

 tatcaaaatc tcaggaaggg aaaaaagagt ctaaagaaca aaatataaca ctattttatt   1917

 tcagtcatgt tagttcagtt tccacagttt gaactgggta tagattaata tctaaaacca   1977

 aaaaatgaac atgtgtatag tgatgctgaa aaatgtgcat tattttttat ttatatttta   2037

 ggaataataa agttagttat taaagaattt agtgattttg attgagtgag aggtgtgagc   2097

 tatatttgct tctttcctgt atgatataca tacattgttt ccaatctcat ttctattaaa   2157

 taactatagg agagcccaca gccttgttat tttacatatc actatttaga tatttgttat   2217

 ttatttattt gtgttggcct gaagtaaatg ttactttttt acgatatttg aaggatagat   2277

 ttattttata aattaatagt ttaaataaga ttttgccagc atttgaaatg atatt        2332




      <210> 36
      <211> 5740
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2154)..(5492)

      <400> 36
 cttccatctc agtgcggctg ttctcggagc tctctgcttt gctcccagca tcgggagact     60

 ttgacttgat gctttcggct tgactattgg ccggggagag tgcctggaag gatgtggttt    120

 ccaggatatc tgggcttcgg ctctgatact cctggtctcc catcagcgag gatgagtcgt    180

 tggtcaagcc atcgctctcc acggaaccgt tttctctgct gccctggcgc tgcaggttaa    240

 aaggggcagg acccactttc cctggggcat ctaaggaagc catcatggca aaccctagcg    300

 tgggtgatgc cgagtggatg ctgggaagag gcgtggggac cttggaggag ctgctgggag    360

 cctcctggga gctgacttcc tctacatcga tgctttcgat gacatcatca tggcagatag    420

 cgccggtgct gccgttctca cccacggtca ttggctcaga acccgtaaag tcacagggat    480

 tctctggcag gggcgtgttg ggaatctgac cgcccatgtg catccgaata tgttgctgca    540

 gcatcacggc attagtgaac ttcttctggc agatggggca cgaatgctgc gtcttaatgg    600

 atgtgttggt tcggtgaacc ccaaggtgtg tcttcaggtt acctttggta gaaaaggctc    660

 ggccacagat cttacactgg aacggtctct ccccggtgtg ggtgcgataa tgcatcttga    720

 gggagctctg acagcttaag actcggtggc aaatgagaca ttcgttggga tcagtggtgg    780

 ccttgtcaat gttctccacc aactgctgca atttcagggt ctctgaccct ggctcagggg    840

 tcccactccc ttggaagcca ccagcccttg gggaattata gtttggtccc accccaggga    900

 gtgtgggtcc accctcactt tctggagaag gcccaggctg caggtcaccg ggcaaggagc    960

 cacccgtgag gtccttggga ttagtccccg aagaaagatt ctgaggtagc cctacagagg   1020

 tggttacaag gacaggtttg ctgtctaaag aaagactcgg ttcatctatg gggtcaggta   1080

 cagagagtgc ataggggatg ccattgccgg ccgccacttt gtcctggaac tcggcaaaca   1140

 gctgggggtt tgccttcacc tggggatgtc ggtgaaagtg caccttgagg ttgcccttgg   1200

 tggtgaagcg atgaccacag acagagcaca cgaagggtct ctctccagtg tgggagcgga   1260

 ggtggatctg caaggagcta tcagtcccaa aaaccttgct acagtactta cacttgtgct   1320

 tgtagagggc cgcctcgtct ttgggtttga catccaccgc ggagatgttc ggtggcttcc   1380

 ccttcccttt cttggatgtg tctagcgcca cagtggagaa agggctctgg aagagcaccg   1440

 agcccggggc ctgaggaagc aaagcgctcg ggaggcggga catgacgttc gggagcaccc   1500

 gggtcccatc cggcttcaga gtgaagggtg ccagccctgg ggacagggag ctggtggcag   1560

 aagggatgtt ggcgtgaggt agcttggctt gtttcaaggc atccagagac agaccttggc   1620

 ttccagcttt ctggctgagc aaagccacag ctgcagaaac ctgctgagac atgtggctgc   1680

 ccaaggtctt cagagtgtcg gcccctgccc cgcttgagtg gagggcgtgg gaggcccaca   1740

 tgttcacctg gatgcggatc tgctcggtga gctggatctg ctgtagctgc tgctgctgca   1800

 gacacaagat ctgctcgagg acccacggga tgctgttggc accaggcacg ggggcaggga   1860

 gtgcatccgc gctccgctga ttcaccgcca ccttggtgcc ccgtagtgcc tgcaaggtca   1920

 cattagtgtt ggccactttg cctttggcta aatagcttat gtcctggggg gtgggtggca   1980

 gggctgtctc tgtctttagg tacaccacag actccgcatc cggcttctcc ttcatgtcct   2040

 ctgagctgcc gccattctcc ctgtgacagt ccttactgcc gggactggtg ggctggtggc   2100

 tcagtacagc tccggagaag tcttctgaag gcacaggccc ctcgctgtca ttc   atg    2156
                                                              Met
                                                                1

 atg agg aca ggt gga ttt tta gtg caa ttt ttc tta tgt tcc agg aac     2204
 Met Arg Thr Gly Gly Phe Leu Val Gln Phe Phe Leu Cys Ser Arg Asn
               5                  10                  15

 tca gag atg ctg aag aac tcc gca cag cat ttc tca cag acg tgc gtc     2252
 Ser Glu Met Leu Lys Asn Ser Ala Gln His Phe Ser Gln Thr Cys Val
          20                  25                  30

 tcc tcc cga cga agc cgc ttt act gtg gct tca tcc tca ctc gcc acc     2300
 Ser Ser Arg Arg Ser Arg Phe Thr Val Ala Ser Ser Ser Leu Ala Thr
      35                  40                  45

 tcg tca ttc cct ggg tgg ttc act gga gca ctg tcg agg cgc aag cag     2348
 Ser Ser Phe Pro Gly Trp Phe Thr Gly Ala Leu Ser Arg Arg Lys Gln
  50                  55                  60                  65

 gcg aaa ccc cag cac atc aac tcg gag gag gac cag ggc gag cag cag     2396
 Ala Lys Pro Gln His Ile Asn Ser Glu Glu Asp Gln Gly Glu Gln Gln
                  70                  75                  80

 ccg cag cag cag acc ccg gag ttt gca gat gcg gcc cca gcg gcg ccc     2444
 Pro Gln Gln Gln Thr Pro Glu Phe Ala Asp Ala Ala Pro Ala Ala Pro
              85                  90                  95

 gcg gcg ggg gag ctg ggt gct cca gtg aac cac cca ggg aat gac gag     2492
 Ala Ala Gly Glu Leu Gly Ala Pro Val Asn His Pro Gly Asn Asp Glu
         100                 105                 110

 gtg gcg agt gag gat gaa gcc aca gta aag cgg ctt cgt cgg gag gag     2540
 Val Ala Ser Glu Asp Glu Ala Thr Val Lys Arg Leu Arg Arg Glu Glu
     115                 120                 125

 acg cac gtc tgt gag aaa tgc tgt gcg gag ttc ttc agc atc tct gag     2588
 Thr His Val Cys Glu Lys Cys Cys Ala Glu Phe Phe Ser Ile Ser Glu
 130                 135                 140                 145

 ttc ctg gaa cat aag aaa aat tgc act aaa aat cca cct gtc ctc atc     2636
 Phe Leu Glu His Lys Lys Asn Cys Thr Lys Asn Pro Pro Val Leu Ile
                 150                 155                 160

 atg aat gac agc gag ggg cct gtg cct tca gaa gac ttc tcc gga gct     2684
 Met Asn Asp Ser Glu Gly Pro Val Pro Ser Glu Asp Phe Ser Gly Ala
             165                 170                 175

 gta ctg agc cac cag ccc acc agt ccc ggc agt aag gac tgt cac agg     2732
 Val Leu Ser His Gln Pro Thr Ser Pro Gly Ser Lys Asp Cys His Arg
         180                 185                 190

 gag aat ggc ggc agc tca gag gac atg aag gag aag ccg gat gcg gag     2780
 Glu Asn Gly Gly Ser Ser Glu Asp Met Lys Glu Lys Pro Asp Ala Glu
     195                 200                 205

 tct gtg gtg tac cta aag aca gag aca gcc ctg cca ccc acc ccc cag     2828
 Ser Val Val Tyr Leu Lys Thr Glu Thr Ala Leu Pro Pro Thr Pro Gln
 210                 215                 220                 225

 gac ata agc tat tta gcc aaa ggc aaa gtg gcc aac act aat gtg acc     2876
 Asp Ile Ser Tyr Leu Ala Lys Gly Lys Val Ala Asn Thr Asn Val Thr
                 230                 235                 240

 ttg cag gca cta cgg ggc acc aag gtg gcg gtg aat cag cgg agc gcg     2924
 Leu Gln Ala Leu Arg Gly Thr Lys Val Ala Val Asn Gln Arg Ser Ala
             245                 250                 255

 gat gca ctc cct gcc ccc gtg cct ggt gcc aac agc atc ccg tgg gtc     2972
 Asp Ala Leu Pro Ala Pro Val Pro Gly Ala Asn Ser Ile Pro Trp Val
         260                 265                 270

 ctc gag cag atc ttg tgt ctg cag cag cag cag cta cag cag atc cag     3020
 Leu Glu Gln Ile Leu Cys Leu Gln Gln Gln Gln Leu Gln Gln Ile Gln
     275                 280                 285

 ctc acc gag cag atc cgc atc cag gtg aac atg tgg gcc tcc cac gcc     3068
 Leu Thr Glu Gln Ile Arg Ile Gln Val Asn Met Trp Ala Ser His Ala
 290                 295                 300                 305

 ctc cac tca agc ggg gca ggg gcc gac act ctg aag acc ttg ggc agc     3116
 Leu His Ser Ser Gly Ala Gly Ala Asp Thr Leu Lys Thr Leu Gly Ser
                 310                 315                 320

 cac atg tct cag cag gtt tct gca gct gtg gct ttg ctc agc cag aaa     3164
 His Met Ser Gln Gln Val Ser Ala Ala Val Ala Leu Leu Ser Gln Lys
             325                 330                 335

 gct gga agc caa ggt ctg tct ctg gat gcc ttg aaa caa gcc aag cta     3212
 Ala Gly Ser Gln Gly Leu Ser Leu Asp Ala Leu Lys Gln Ala Lys Leu
         340                 345                 350

 cct cac gcc aac atc cct tct gcc acc agc tcc ctg tcc cca ggg ctg     3260
 Pro His Ala Asn Ile Pro Ser Ala Thr Ser Ser Leu Ser Pro Gly Leu
     355                 360                 365

 gca ccc ttc act ctg aag ccg gat ggg acc cgg gtg ctc ccg aac gtc     3308
 Ala Pro Phe Thr Leu Lys Pro Asp Gly Thr Arg Val Leu Pro Asn Val
 370                 375                 380                 385

 atg tcc cgc ctc ccg agc gct ttg ctt cct cag gcc ccg ggc tcg gtg     3356
 Met Ser Arg Leu Pro Ser Ala Leu Leu Pro Gln Ala Pro Gly Ser Val
                 390                 395                 400

 ctc ttc cag agc cct ttc tcc act gtg gcg cta gac aca tcc aag aaa     3404
 Leu Phe Gln Ser Pro Phe Ser Thr Val Ala Leu Asp Thr Ser Lys Lys
             405                 410                 415

 ggg aag ggg aag cca ccg aac atc tcc gcg gtg gat gtc aaa ccc aaa     3452
 Gly Lys Gly Lys Pro Pro Asn Ile Ser Ala Val Asp Val Lys Pro Lys
         420                 425                 430

 gac gag gcg gcc ctc tac aag cac aag tgt aag tac tgt agc aag gtt     3500
 Asp Glu Ala Ala Leu Tyr Lys His Lys Cys Lys Tyr Cys Ser Lys Val
     435                 440                 445

 ttt ggg act gat agc tcc ttg cag atc cac ctc cgc tcc cac act gga     3548
 Phe Gly Thr Asp Ser Ser Leu Gln Ile His Leu Arg Ser His Thr Gly
 450                 455                 460                 465

 gag aga ccc ttc gtg tgc tct gtc tgt ggt cat cgc ttc acc acc aag     3596
 Glu Arg Pro Phe Val Cys Ser Val Cys Gly His Arg Phe Thr Thr Lys
                 470                 475                 480

 ggc aac ctc aag gtg cac ttt cac cga cat ccc cag gtg aag gca aac     3644
 Gly Asn Leu Lys Val His Phe His Arg His Pro Gln Val Lys Ala Asn
             485                 490                 495

 ccc cag ctg ttt gcc gag ttc cag gac aaa gtg gcg gcc ggc aat ggc     3692
 Pro Gln Leu Phe Ala Glu Phe Gln Asp Lys Val Ala Ala Gly Asn Gly
         500                 505                 510

 atc ccc tat gca ctc tct gta cct gac ccc ata gat gaa ccg agt ctt     3740
 Ile Pro Tyr Ala Leu Ser Val Pro Asp Pro Ile Asp Glu Pro Ser Leu
     515                 520                 525

 tct tta gac agc aaa cct gtc ctt gta acc acc tct gta ggg cta cct     3788
 Ser Leu Asp Ser Lys Pro Val Leu Val Thr Thr Ser Val Gly Leu Pro
 530                 535                 540                 545

 cag aat ctt tct tcg ggg act aat ccc aag gac ctc acg ggt ggc tcc     3836
 Gln Asn Leu Ser Ser Gly Thr Asn Pro Lys Asp Leu Thr Gly Gly Ser
                 550                 555                 560

 ttg ccc ggt gac ctg cag cct ggg cct tct cca gaa agt gag ggt gga     3884
 Leu Pro Gly Asp Leu Gln Pro Gly Pro Ser Pro Glu Ser Glu Gly Gly
             565                 570                 575

 ccc aca ctc cct ggg gtg gga cca aac tat aat tcc cca agg gct ggt     3932
 Pro Thr Leu Pro Gly Val Gly Pro Asn Tyr Asn Ser Pro Arg Ala Gly
         580                 585                 590

 ggc ttc caa ggg agt ggg acc cct gag cca ggg tca gag acc ctg aaa     3980
 Gly Phe Gln Gly Ser Gly Thr Pro Glu Pro Gly Ser Glu Thr Leu Lys
     595                 600                 605

 ttg cag cag ttg gtg gag aac att gac aag gcc acc act gat ccc aac     4028
 Leu Gln Gln Leu Val Glu Asn Ile Asp Lys Ala Thr Thr Asp Pro Asn
 610                 615                 620                 625

 gaa tgt ctc att tgc cac cga gtc tta agc tgt cag agc tcc ctc aag     4076
 Glu Cys Leu Ile Cys His Arg Val Leu Ser Cys Gln Ser Ser Leu Lys
                 630                 635                 640

 atg cat tat cgc acc cac acc ggg gag aga ccg ttc cag tgt aag atc     4124
 Met His Tyr Arg Thr His Thr Gly Glu Arg Pro Phe Gln Cys Lys Ile
             645                 650                 655

 tgt ggc cga gcc ttt tct acc aaa ggt aac ctg aag aca cac ctt ggg     4172
 Cys Gly Arg Ala Phe Ser Thr Lys Gly Asn Leu Lys Thr His Leu Gly
         660                 665                 670

 gtt cac cga acc aac acg tcc att aag acg cag cat tcg tgc ccc atc     4220
 Val His Arg Thr Asn Thr Ser Ile Lys Thr Gln His Ser Cys Pro Ile
     675                 680                 685

 tgc cag aag aag ttc act aat gcc gtg atg ctg cag caa cat att cgg     4268
 Cys Gln Lys Lys Phe Thr Asn Ala Val Met Leu Gln Gln His Ile Arg
 690                 695                 700                 705

 atg cac atg ggc ggt cag att ccc aac acg ccc ctg cca gag aat ccc     4316
 Met His Met Gly Gly Gln Ile Pro Asn Thr Pro Leu Pro Glu Asn Pro
                 710                 715                 720

 tgt gac ttt acg ggt tct gag cca atg acc gtg ggt gag aac ggc agc     4364
 Cys Asp Phe Thr Gly Ser Glu Pro Met Thr Val Gly Glu Asn Gly Ser
             725                 730                 735

 acc ggc gct atc tgc cat gat gat gtc atc gaa agc atc gat gta gag     4412
 Thr Gly Ala Ile Cys His Asp Asp Val Ile Glu Ser Ile Asp Val Glu
         740                 745                 750

 gaa gtc agc tcc cag gag gct ccc agc agc tcc tcc aag gtc ccc acg     4460
 Glu Val Ser Ser Gln Glu Ala Pro Ser Ser Ser Ser Lys Val Pro Thr
     755                 760                 765

 cct ctt ccc agc atc cac tcg gca tca ccc acg cta ggg ttt gcc atg     4508
 Pro Leu Pro Ser Ile His Ser Ala Ser Pro Thr Leu Gly Phe Ala Met
 770                 775                 780                 785

 atg gct tcc tta gat gcc cca ggg aaa gtg ggt cct gcc cct ttt aac     4556
 Met Ala Ser Leu Asp Ala Pro Gly Lys Val Gly Pro Ala Pro Phe Asn
                 790                 795                 800

 ctg cag cgc cag ggc agc aga gaa aac ggt tcc gtg gag agc gat ggc     4604
 Leu Gln Arg Gln Gly Ser Arg Glu Asn Gly Ser Val Glu Ser Asp Gly
             805                 810                 815

 ttg acc aac gac tca tcc tcg ctg atg gga gac cag gag tat cag agc     4652
 Leu Thr Asn Asp Ser Ser Ser Leu Met Gly Asp Gln Glu Tyr Gln Ser
         820                 825                 830

 cga agc cca gat atc ctg gaa acc aca tcc ttc cag gca ctc tcc ccg     4700
 Arg Ser Pro Asp Ile Leu Glu Thr Thr Ser Phe Gln Ala Leu Ser Pro
     835                 840                 845

 gcc aat agt caa gcc gaa agc atc aag tca aag tct ccc gat gct ggg     4748
 Ala Asn Ser Gln Ala Glu Ser Ile Lys Ser Lys Ser Pro Asp Ala Gly
 850                 855                 860                 865

 agc aaa gca gag agc tcc gag aac agc cgc act gag atg gaa ggt cgg     4796
 Ser Lys Ala Glu Ser Ser Glu Asn Ser Arg Thr Glu Met Glu Gly Arg
                 870                 875                 880

 agc agt ctc cct tcc acg ttt atc cga gcc ccg ccg acc tat gtc aag     4844
 Ser Ser Leu Pro Ser Thr Phe Ile Arg Ala Pro Pro Thr Tyr Val Lys
             885                 890                 895

 gtt gaa gtt cct ggc aca ttt gtg gga ccc tcg aca ttg tcc cca ggg     4892
 Val Glu Val Pro Gly Thr Phe Val Gly Pro Ser Thr Leu Ser Pro Gly
         900                 905                 910

 atg acc cct ttg tta gca gcc cag cca cgc cga cag gcc aag caa cat     4940
 Met Thr Pro Leu Leu Ala Ala Gln Pro Arg Arg Gln Ala Lys Gln His
     915                 920                 925

 ggc tgc aca cgg tgt ggg aag aac ttc tcg tct gct agc gct ctt cag     4988
 Gly Cys Thr Arg Cys Gly Lys Asn Phe Ser Ser Ala Ser Ala Leu Gln
 930                 935                 940                 945

 atc cac gag cgg act cac act gga gag aag cct ttt gtg tgc aac att     5036
 Ile His Glu Arg Thr His Thr Gly Glu Lys Pro Phe Val Cys Asn Ile
                 950                 955                 960

 tgt ggg cga gct ttt acc acc aaa ggc aac tta aag gtt cac tac atg     5084
 Cys Gly Arg Ala Phe Thr Thr Lys Gly Asn Leu Lys Val His Tyr Met
             965                 970                 975

 aca cac ggg gcg aac aat aac tca gcc cgc cgt gga agg aag ttg gcc     5132
 Thr His Gly Ala Asn Asn Asn Ser Ala Arg Arg Gly Arg Lys Leu Ala
         980                 985                 990

 atc gag aac acc atg gct ctg tta ggt acg gac gga aaa aga gtc tca     5180
 Ile Glu Asn Thr Met Ala Leu Leu Gly Thr Asp Gly Lys Arg Val Ser
     995                1000                1005

 gaa atc ttt ccc aag gaa atc ctg gcc cct tca gtg aat gtg gac cct     5228
 Glu Ile Phe Pro Lys Glu Ile Leu Ala Pro Ser Val Asn Val Asp Pro
1010                1015                1020                1025

 gtt gtg tgg aac cag tac acc agc atg ctc aat ggc ggt ctg gcc gtg     5276
 Val Val Trp Asn Gln Tyr Thr Ser Met Leu Asn Gly Gly Leu Ala Val
                1030                1035                1040

 aag acc aat gag atc tct gtg atc cag agt ggg ggg gtt cct acc ctc     5324
 Lys Thr Asn Glu Ile Ser Val Ile Gln Ser Gly Gly Val Pro Thr Leu
            1045                1050                1055

 ccg gtt tcc ttg ggg gcc acc tcc gtt gtg aat aac gcc act gtc tcc     5372
 Pro Val Ser Leu Gly Ala Thr Ser Val Val Asn Asn Ala Thr Val Ser
        1060                1065                1070

 aag atg gat ggc tcc cag tcg ggt atc agt gca gat gtg gaa aaa cca     5420
 Lys Met Asp Gly Ser Gln Ser Gly Ile Ser Ala Asp Val Glu Lys Pro
    1075                1080                1085

 agt gct act gac ggc gtt ccc aaa cac cag ttt cct cac ttc ctg gaa     5468
 Ser Ala Thr Asp Gly Val Pro Lys His Gln Phe Pro His Phe Leu Glu
1090                1095                1100                1105

 gaa aac aag att gcg gtc agc taa gggagaactt gcgtggaagg agcaatgcag    5522
 Glu Asn Lys Ile Ala Val Ser 
                1110

 acacagtgaa atctctagaa tctgctttgt tttgtaagaa ctcatctcct cctgttttct   5582

 ttttcttact gatatgcaaa tgatgtttac tacgttggtt gtgaccacaa cctcaggcaa   5642

 gtgctacaat cacgattgtt gctatgctgc tttgcaaaaa gttgaaaaaa aaaaaaaaaa   5702

 atgcatacca aaaaaaaaaa aaaaaaaaaa aaagattt                           5740




      <210> 37
      <211> 720
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(720)

      <400> 37
  atg atg gcg gcg cgg cgg cgg gct ggg ctg gtg cct ggc ggg cgc tgt      48
  Met Met Ala Ala Arg Arg Arg Ala Gly Leu Val Pro Gly Gly Arg Cys
    1               5                  10                  15

 gag gcg cgc gat ccc cgg tgt ctt ggg agc agt gcc ccg gcc ccc gcc       96
 Glu Ala Arg Asp Pro Arg Cys Leu Gly Ser Ser Ala Pro Ala Pro Ala
              20                  25                  30

 gct ccc gcc gcc gcc atg tcg ggc cgg tcg gtc cgg gcg gag acc cgc      144
 Ala Pro Ala Ala Ala Met Ser Gly Arg Ser Val Arg Ala Glu Thr Arg
          35                  40                  45

 agc cgg gcc aag gac gac atc aag aag gtg atg gcg gcc atc gag aaa      192
 Ser Arg Ala Lys Asp Asp Ile Lys Lys Val Met Ala Ala Ile Glu Lys
      50                  55                  60

 gtg cgg aaa tgg gag aag aag tgg gtg act gtg ggt gac acg tcc ctg      240
 Val Arg Lys Trp Glu Lys Lys Trp Val Thr Val Gly Asp Thr Ser Leu
  65                  70                  75                  80

 agg ata ttt aag tgg gtt cct gtg aca gac agc aag gag aaa gaa aag      288
 Arg Ile Phe Lys Trp Val Pro Val Thr Asp Ser Lys Glu Lys Glu Lys
                  85                  90                  95

 tca aaa tcg aac agt tca gca gcc cga gaa cct aat ggc ttt cct tct      336
 Ser Lys Ser Asn Ser Ser Ala Ala Arg Glu Pro Asn Gly Phe Pro Ser
             100                 105                 110

 gat gcc tca gcc aat tcc tct ctc ctt ctt gaa ttc cag gac gaa aac      384
 Asp Ala Ser Ala Asn Ser Ser Leu Leu Leu Glu Phe Gln Asp Glu Asn
         115                 120                 125

 agc aac cag agt tcc gtg tct gac gtc tat cag ctt aag gtg gac agc      432
 Ser Asn Gln Ser Ser Val Ser Asp Val Tyr Gln Leu Lys Val Asp Ser
     130                 135                 140

 agc acc aac tca agc ccc agc ccc cag cag agt gag tcc ctg agc cca      480
 Ser Thr Asn Ser Ser Pro Ser Pro Gln Gln Ser Glu Ser Leu Ser Pro
 145                 150                 155                 160

 gca cac acc tcc gac ttc cgc acg gat gac tcc cag ccc cca acg ctg      528
 Ala His Thr Ser Asp Phe Arg Thr Asp Asp Ser Gln Pro Pro Thr Leu
                 165                 170                 175

 ggc cag gag atc ctg gag gag ccc tcc ctg ccc tcc tcg gaa gtt gct      576
 Gly Gln Glu Ile Leu Glu Glu Pro Ser Leu Pro Ser Ser Glu Val Ala
             180                 185                 190

 gat gaa cct cct acc ctc acc aag gaa gaa cca gtt cca cta gag aca      624
 Asp Glu Pro Pro Thr Leu Thr Lys Glu Glu Pro Val Pro Leu Glu Thr
         195                 200                 205

 cag gtc gtt gag gaa gag gaa gac tca ggt gcc ccg ccc ctg aag cgc      672
 Gln Val Val Glu Glu Glu Glu Asp Ser Gly Ala Pro Pro Leu Lys Arg
     210                 215                 220

 ttc tgt gtg gac caa ccc aca gtg ccg cag acg gcg tca gaa agc tag      720
 Phe Cys Val Asp Gln Pro Thr Val Pro Gln Thr Ala Ser Glu Ser 
 225                 230                 235





      <210> 38
      <211> 605
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (105)..(551)

      <400> 38
 aaagaaaaca tagggatttg gccccgagga agaaattcgg cacgagacgc gggccaaggg     60

 atgatcgaac gtgcgtctag catttgacca cgcagctttc agtc atg gcc tcc ggt     116
                                                  Met Ala Ser Gly
                                                    1

 aac gcg cgc atc gga aag aca gcc cct gac ttc aag gac aca gcg gtg      164
 Asn Ala Arg Ile Gly Lys Thr Ala Pro Asp Phe Lys Asp Thr Ala Val
   5                  10                  15                  20

 gtt gat ggc gcc ttc aaa gag gtg aag ctg tcg gac tac aaa ggg aag      212
 Val Asp Gly Ala Phe Lys Glu Val Lys Leu Ser Asp Tyr Lys Gly Lys
                  25                  30                  35

 atc aac acc ccc cgg aaa gag gga ggc ttg ggc ccc ctg aac atc cac      260
 Ile Asn Thr Pro Arg Lys Glu Gly Gly Leu Gly Pro Leu Asn Ile His
              40                  45                  50

 ctg ctt gct gac gtg acc aga cgc ttg tct gag gat tac ggc gtg ctg      308
 Leu Leu Ala Asp Val Thr Arg Arg Leu Ser Glu Asp Tyr Gly Val Leu
          55                  60                  65

 aaa aca gat gag ggc att gcc tac agg ggc ctc ttt atc atc gat ggc      356
 Lys Thr Asp Glu Gly Ile Ala Tyr Arg Gly Leu Phe Ile Ile Asp Gly
      70                  75                  80

 aag ggt gtc ctt cgc cag atc act gtt aat gat ttg cct gtg gga cgc      404
 Lys Gly Val Leu Arg Gln Ile Thr Val Asn Asp Leu Pro Val Gly Arg
  85                  90                  95                 100

 tcc gtg gat gag gct ctg cgg ctg gtc cag gcc ttc cag tac aca gac      452
 Ser Val Asp Glu Ala Leu Arg Leu Val Gln Ala Phe Gln Tyr Thr Asp
                 105                 110                 115

 gag cat ggg gaa gtt tgt ccc gct ggc tgg aag cct ggc agt gac acg      500
 Glu His Gly Glu Val Cys Pro Ala Gly Trp Lys Pro Gly Ser Asp Thr
             120                 125                 130

 att aag ccc aac gtg gat gac agc aag gaa tat ttc tcc aaa cac aat      548
 Ile Lys Pro Asn Val Asp Asp Ser Lys Glu Tyr Phe Ser Lys His Asn
         135                 140                 145

 tag gctg gctaacggat agtgagcttg tgcccctgcc taggtgcctg tgctgggtgt      605
 






      <210> 39
      <211> 854
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (154)..(807)

      <400> 39
 cagccccctc tgcggctgcc gctgccgggc gggcccgggc gcccgggggc tggggggtgg     60

 gggaggacgc cgagcgttga ggcaggggcc cgggccgagg gcgcggcggg gctgcgcgca    120

 cgatggggcg cgtggagggg cgcggagggc gaa atg agt ctg gta ggt ggt ttt     174
                                      Met Ser Leu Val Gly Gly Phe
                                        1               5

 ccc cac cac ccg gtg gtg cac cac gag ggc tac ccg ttt gcc gcg gcc      222
 Pro His His Pro Val Val His His Glu Gly Tyr Pro Phe Ala Ala Ala
          10                  15                  20

 gcc gcc gca gct gcc gcc gcc gcc gcc agc cgc tgc agc cac gag gag      270
 Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Arg Cys Ser His Glu Glu
      25                  30                  35

 aac ccc tac ttc cat ggc tgg ctc att ggc cac ccg gag atg tcg ccc      318
 Asn Pro Tyr Phe His Gly Trp Leu Ile Gly His Pro Glu Met Ser Pro
  40                  45                  50                  55

 ccc gac tac agc atg gcc ctg tcc tac agc ccc gag tat gcc agc ggc      366
 Pro Asp Tyr Ser Met Ala Leu Ser Tyr Ser Pro Glu Tyr Ala Ser Gly
                  60                  65                  70

 gcc gcc ggc ctg gac cac tcc cat tac ggg ggg gtg ccg ccg ggc gcc      414
 Ala Ala Gly Leu Asp His Ser His Tyr Gly Gly Val Pro Pro Gly Ala
              75                  80                  85

 ggg ccc ccg ggc ctg ggg ggg ccg cgc ccg gtg aag cgc cga ggc acc      462
 Gly Pro Pro Gly Leu Gly Gly Pro Arg Pro Val Lys Arg Arg Gly Thr
          90                  95                 100

 gcc aac cgc aag gag cgg cgc agg act cag agc atc aac agc gcc ttc      510
 Ala Asn Arg Lys Glu Arg Arg Arg Thr Gln Ser Ile Asn Ser Ala Phe
     105                 110                 115

 gcc gaa ctg cgc gag tgc atc ccc aac gta ccc gcc gac acc aaa ctc      558
 Ala Glu Leu Arg Glu Cys Ile Pro Asn Val Pro Ala Asp Thr Lys Leu
 120                 125                 130                 135

 tcc aaa atc aag acc ctg cgc ctg gcc acc agc tac atc gcc tac ctc      606
 Ser Lys Ile Lys Thr Leu Arg Leu Ala Thr Ser Tyr Ile Ala Tyr Leu
                 140                 145                 150

 atg gac ctg ctg gcc aag gac gac cag aat ggc gag gcg gag gcc ttc      654
 Met Asp Leu Leu Ala Lys Asp Asp Gln Asn Gly Glu Ala Glu Ala Phe
             155                 160                 165

 aag gca gag atc aag aag acc gac gtg aaa gag gag aag agg aag aag      702
 Lys Ala Glu Ile Lys Lys Thr Asp Val Lys Glu Glu Lys Arg Lys Lys
         170                 175                 180

 gag ctg aac gaa atc ttg aaa agc aca gtg agc agc aac gac aag aaa      750
 Glu Leu Asn Glu Ile Leu Lys Ser Thr Val Ser Ser Asn Asp Lys Lys
     185                 190                 195

 acc aaa ggc cgg acg ggc tgg ccg cag cac gtc tgg gcc ctg gag ctc      798
 Thr Lys Gly Arg Thr Gly Trp Pro Gln His Val Trp Ala Leu Glu Leu
 200                 205                 210                 215

 aag cag tga ggaggag gagaaggagg aggaggagag cgcgagtgag caggggccaa      854
 Lys Gln 






      <210> 40
      <211> 825
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (7)..(414)

      <400> 40
 cccagc   atg agc ggc ctg cgc gtc tac agc acg tcg gtc acc ggc tcc      48
          Met Ser Gly Leu Arg Val Tyr Ser Thr Ser Val Thr Gly Ser
            1               5                  10

 cgc gaa atc aag tcc cag cag agc gag gtg acc cga atc ctg gat ggg       96
 Arg Glu Ile Lys Ser Gln Gln Ser Glu Val Thr Arg Ile Leu Asp Gly
  15                  20                  25                  30

 aag cgc atc caa tac cag cta gtg gac atc tcc cag gac aac gcc ctg      144
 Lys Arg Ile Gln Tyr Gln Leu Val Asp Ile Ser Gln Asp Asn Ala Leu
                  35                  40                  45

 agg gat gag atg cga gcc ttg gca ggc aac ccc aag gcc acc cca ccc      192
 Arg Asp Glu Met Arg Ala Leu Ala Gly Asn Pro Lys Ala Thr Pro Pro
              50                  55                  60

 cag att gtc aac ggg gac cag tac tgt ggg tat ggg ctg ggg gac ggg      240
 Gln Ile Val Asn Gly Asp Gln Tyr Cys Gly Tyr Gly Leu Gly Asp Gly
          65                  70                  75

 ggg gtg ggg gga gtg ttg gaa gag gac tct agc cag ggt cat atc gtg      288
 Gly Val Gly Gly Val Leu Glu Glu Asp Ser Ser Gln Gly His Ile Val
      80                  85                  90

 cca caa agc act tgc ggc ccc ctg cat tca ggt gac cac ccc tcg cct      336
 Pro Gln Ser Thr Cys Gly Pro Leu His Ser Gly Asp His Pro Ser Pro
  95                 100                 105                 110

 ccc ctt ctc cag gac tat gag ctc ttc gtg gag gct gtg gaa caa aac      384
 Pro Leu Leu Gln Asp Tyr Glu Leu Phe Val Glu Ala Val Glu Gln Asn
                 115                 120                 125

 acg ctg cag gag ttc ctg aag ctg gct tga g tcaagcctgt ccagagttcc      435
 Thr Leu Gln Glu Phe Leu Lys Leu Ala 
             130                 135

 cctgctggac tccatcacca cactcccccc agccttcacc tggccatgaa ggaccttttg    495

 accaactccc tgtcattcct aacctaacct tagagtccct cccccaatgc aggccacttc    555

 tcctccctcc tctctaaatg tagtcccctc tcctccatct aaaggcaaca ttccttaccc    615

 attagtctca gaaattgtct taagcaacag cccaaatgct ggctgccccc agccaagcat    675

 tggggccgcc atcctgcctg gcactggctg atgggcacct ctgttggttc catcagccag    735

 agctctgcaa aggccccgca gtccctctcc caggaggacc ctagaggcaa ttaaatgatg    795

 tcctgttcca aaaaaaaaaa aaaaaaaact                                     825




      <210> 41
      <211> 2144
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (199)..(744)

      <400> 41
 aaggatcctt aattaaatta atcccccctc cccgagtgga agccgccgcc gcgctcgcag     60

 ctcgcaggcg ccgcgtagcc gtcgccaccg ccgccagccc gtgcgccctc ggcgcgtacc    120

 cgccgcgctc ccatccccgc cgccggccag gggcgcgctc ggccgccccg gacagtgtcc    180

 cgctgcggct ccgcggcg  atg gcc acc aag atc gac aaa gag gct tgc cgg     231
                      Met Ala Thr Lys Ile Asp Lys Glu Ala Cys Arg
                        1               5                  10

 gcg gcg tac aac ctg gtg cgc gac gac ggc tcg gcc gtc atc tgg gtg      279
 Ala Ala Tyr Asn Leu Val Arg Asp Asp Gly Ser Ala Val Ile Trp Val
              15                  20                  25

 act ttt aaa tat gac ggc tcc acc atc gtc ccc ggc gag cag gga gcg      327
 Thr Phe Lys Tyr Asp Gly Ser Thr Ile Val Pro Gly Glu Gln Gly Ala
          30                  35                  40

 gag tac cag cac ttc atc cag cag tgc aca gat gac gtc cgg ttg ttt      375
 Glu Tyr Gln His Phe Ile Gln Gln Cys Thr Asp Asp Val Arg Leu Phe
      45                  50                  55

 gcc ttc gtg cgc ttc acc acc ggg gat gcc atg agc aag agg tcc aag      423
 Ala Phe Val Arg Phe Thr Thr Gly Asp Ala Met Ser Lys Arg Ser Lys
  60                  65                  70                  75

 ttt gcc ctc atc acg tgg atc ggt gag aac gtc agc ggg ctg cag cgc      471
 Phe Ala Leu Ile Thr Trp Ile Gly Glu Asn Val Ser Gly Leu Gln Arg
                  80                  85                  90

 gcc aaa acc ggg acg gac aag acc ctg gtg aag gag gtc gta cag aat      519
 Ala Lys Thr Gly Thr Asp Lys Thr Leu Val Lys Glu Val Val Gln Asn
              95                 100                 105

 ttc gct aag gag ttt gtg atc agt gat cgg aag gag ctg gag gaa gat      567
 Phe Ala Lys Glu Phe Val Ile Ser Asp Arg Lys Glu Leu Glu Glu Asp
         110                 115                 120

 ctc atc aag agc gag ctg aag aag gcg ggg gga gcc aat tac gac gcc      615
 Leu Ile Lys Ser Glu Leu Lys Lys Ala Gly Gly Ala Asn Tyr Asp Ala
     125                 130                 135

 cag acg gat gta acc cca gcc ccc ggc aca cca gcc ctt gcc aaa gtc      663
 Gln Thr Asp Val Thr Pro Ala Pro Gly Thr Pro Ala Leu Ala Lys Val
 140                 145                 150                 155

 atc tgc ctg ctc ccc ggg ggg aga gga ccg ccg gcc tca ggt act agc      711
 Ile Cys Leu Leu Pro Gly Gly Arg Gly Pro Pro Ala Ser Gly Thr Ser
                 160                 165                 170

 cca cca gcc cac cag gca gaa gag aag cca tga gaggcagg ccgacagcct      762
 Pro Pro Ala His Gln Ala Glu Glu Lys Pro 
             175                 180

 gtgtccacag acccgcacct tcccgaattc ccattagaac cctgccgagt ccatatcatc    822

 atgacgctca tggaacctcg tttcttgtga gtcattctta ttatcattat atctcccacc    882

 tcttattatg gcttctaaag aaaaggtcat attatgaatg caaagggtca catgaactgg    942

 ccagtcagca tcacgagaga tgcacatcca tgccagatga gaccacattt atacactgga   1002

 cattatcatc attagacacg cgaccgacgg tcatggccat agatgaggaa cctgccatga   1062

 acaatcaaac gattggcata ttccaagaaa gaaccaggga cacataatat atgacgcaat   1122

 catcagtatt atacccttgg gtgaacccat gaattttacc atggatggta cccaccatcg   1182

 gaaaggcggg caagcatgga tgcacaaagc gaagacatcg ttgcccacag tgattgccac   1242

 atgacaagaa caattacaca tataaggaca caaaccaact agatcccaga tatacaccat   1302

 atcttaatgg ggccgcagga accatcacca tggagtatca atagaccaca gtggacaatc   1362

 acaccaatac aaattcgaga tagacattca caattccctg ggaaagtgta agagccacaa   1422

 aaggaattga gcatagaatc ccaaaggaca aattaggagg gaaggtgaag atagacataa   1482

 tgaatatgga gatatgacga aaaactgaga tataagggag atcaacggga gattccaagg   1542

 atcatggaaa agtatagtga agagcaagaa tacaaaaagt ataggacata taaaaaaaca   1602

 attagccaat gatagaaaga atagggatat tataaggcaa tgccaagcag gggtccctag   1662

 caaaaacaca acgaccaatg gattacacca caaccgcaat acgtgcgaag acagcacaga   1722

 agttaaacca aacgaaggaa cacaacaaag gaagaaatgt gcggcacaaa acgaggacat   1782

 tgaggcgacc ccagaacgcg tatgaaaaca cgacagcagg aaccggaaga caccaacaaa   1842

 ggagacaaca caggcaatca caacgggtga tttcacaaac aaagcgagaa ccaacggaca   1902

 tcagaaacaa gagaacagca gaaatggccc atagagaatg atgcaagact caagcgccaa   1962

 cgtagaaaaa gacacgacac aagggagaga cgagaagtac ccagacaagc caacagaacc   2022

 agcaattcag gaggtcaaaa atgaaacaag gacatgaaat aagtgccaaa aaaaggacgg   2082

 aacacaagca caagagccga caagacaaga gagaaacgta gacgagagaa gcatggaaat   2142

 ac                                                                  2144




      <210> 42
      <211> 2019
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (111)..(929)

      <220>
      <221> misc_feature
      <222> (1)...(2019)
      <223> n = a,t,c or g

      <400> 42
 agcggggtcc gcggggcggg gcgggggcgc ggccgggtgg atggcaggtg gctgcgagca     60

 gacggcggtc gcgtcggcga tcaggctcgg ggtcggtaag gggtgcggca   atg ctg     116
                                                          Met Leu
                                                            1

 caa ctg cgg gac tcg gtg gac tcg gcc ggt acg agc ccc acg gcg gtg      164
 Gln Leu Arg Asp Ser Val Asp Ser Ala Gly Thr Ser Pro Thr Ala Val
           5                  10                  15

 ctg gcg gcc ggc gag gag gtg ggg gca ggc ggc ggc ccg ggc ggg ggg      212
 Leu Ala Ala Gly Glu Glu Val Gly Ala Gly Gly Gly Pro Gly Gly Gly
      20                  25                  30

 cgg ccg ggg gcg ggg acg ccg ctg cgc cag aca ctc tgg cct ctc agc      260
 Arg Pro Gly Ala Gly Thr Pro Leu Arg Gln Thr Leu Trp Pro Leu Ser
  35                  40                  45                  50

 atc cac gac ccc acg cgc cgc gcc cgc gtc aag gag tac ttc gtg ttc      308
 Ile His Asp Pro Thr Arg Arg Ala Arg Val Lys Glu Tyr Phe Val Phe
                  55                  60                  65

 cgg ccc ggc agc atc gag cag gca gtg gag gag atc cgc gtg gtg gtg      356
 Arg Pro Gly Ser Ile Glu Gln Ala Val Glu Glu Ile Arg Val Val Val
              70                  75                  80

 cgg ccc gtg gag gac ggc gag atc cag gga gtg tgg ctg ctt acc gag      404
 Arg Pro Val Glu Asp Gly Glu Ile Gln Gly Val Trp Leu Leu Thr Glu
          85                  90                  95

 gtg gat cac tgg aac aat gag aag gag cgg ctg gtg ctg gtc acg gag      452
 Val Asp His Trp Asn Asn Glu Lys Glu Arg Leu Val Leu Val Thr Glu
     100                 105                 110

 cag tcc ctg ctt atc tgt aaa tac gac ttc atc agt ctc cag tgc cag      500
 Gln Ser Leu Leu Ile Cys Lys Tyr Asp Phe Ile Ser Leu Gln Cys Gln
 115                 120                 125                 130

 cag gtg gtg cgg ata gcg ctc aac gca gta gac acc att tcc tac gga      548
 Gln Val Val Arg Ile Ala Leu Asn Ala Val Asp Thr Ile Ser Tyr Gly
                 135                 140                 145

 gaa ttc cag ttt ccc cct aaa tcg ctc aac aag cga gaa ggt ttt ggg      596
 Glu Phe Gln Phe Pro Pro Lys Ser Leu Asn Lys Arg Glu Gly Phe Gly
             150                 155                 160

 att cga att cag tgg gac aag caa agt cgt cct tcc ttc ata aac aga      644
 Ile Arg Ile Gln Trp Asp Lys Gln Ser Arg Pro Ser Phe Ile Asn Arg
         165                 170                 175

 tgg aat ccc tgg tct acc aac gtg ccc tat gcc act ttc aca gaa cac      692
 Trp Asn Pro Trp Ser Thr Asn Val Pro Tyr Ala Thr Phe Thr Glu His
     180                 185                 190

 ccg atg gct ggc gca gat gag aag aca gca tct ctg tgt cag ttg gaa      740
 Pro Met Ala Gly Ala Asp Glu Lys Thr Ala Ser Leu Cys Gln Leu Glu
 195                 200                 205                 210

 agc ttc aag gct ctg tta atc caa gct gtc aaa aaa gcc caa aaa gaa      788
 Ser Phe Lys Ala Leu Leu Ile Gln Ala Val Lys Lys Ala Gln Lys Glu
                 215                 220                 225

 agc cct ttg cca gga cag gcg aat ggc gtg ctg atc ctg gag cgc ccc      836
 Ser Pro Leu Pro Gly Gln Ala Asn Gly Val Leu Ile Leu Glu Arg Pro
             230                 235                 240

 ctg ctc atc gag acc tac gtg gga ctc atg tcc ttc att aac aac gag      884
 Leu Leu Ile Glu Thr Tyr Val Gly Leu Met Ser Phe Ile Asn Asn Glu
         245                 250                 255

 gcg aaa ctg ggc tac tcc atg acc agg ggc aaa ata ggc ttt tag ccg      932
 Ala Lys Leu Gly Tyr Ser Met Thr Arg Gly Lys Ile Gly Phe 
     260                 265                 270

 ctgcgttctg ggagctcctc cccctcccca gaaggccaag ggatgtgggg gctgggggac    992

 tgggaggcct ggcagtcttc atgctgccct gctgctgctg gaaggatggg gatctttcac   1052

 ctttagggat ctcagcacaa ttagaatcgt aaagtgaatt ctatctattt aattggatat   1112

 tggactctgc tcatataagc tacagacaaa agccaaaaga ctctcgctgt ccctgtgctg   1172

 ctggtatttc attctctgta acttcagttc tggtgttttc cttgagtatc tacttggctt   1232

 ctcgtggttt ttcccacccc agctgcccca gcacgcggga cccatagcac accccttagc   1292

 gcttgcctag gttgctgaaa acagggaggc acctggtatc tcgagtgcct gcagttgcaa   1352

 gtgtgtttac acctggtgtc caattttgta ttttaaaatg taatccattt ttacttcagc   1412

 tcatccaaaa gcagccagca gaccggttga ctgagaccgg tctgtggctg tgggcccctt   1472

 ggtgacccgc tgctcttttg gaaatgggtg acctgaagtg acactttttc cacaattaac   1532

 ccaagttgtg ttaatacttc aggtctgttt cccagaccca gaaagcttta cagaaaatca   1592

 ttgtaagaca atttattaat ttgagaaagt caccttgaca gttctttgca cacaagtttt   1652

 acacctctct ggattcgaag tttgtattgt attcatagtt aaagggaact cgggtacttt   1712

 gcttgttgaa taaatgcact ttaaaacaag gaaccgtatc aggcagcatg gtggtcatgc   1772

 tgtgaatcca agcatgtggn gaggtcaggc agacaatcgt ctagtcagaa ttggagagag   1832

 ctgggcacat ggtggaaccg ctctacaaag aaaaaagcgc aggtggtggc atctggggcc   1892

 acctcgaagt gtcacgaggt ccttggccga ggggtgggcg gtggtaggcc tttggttccg   1952

 ggaagaagcc acaacatgag ggggcccggc acccgggggg ggacgccaca cccgcggggg   2012

 gggcccc                                                             2019




      <210> 43
      <211> 2615
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (119)..(1891)

      <400> 43
 gctgtcgttg ttctgagcta aagaagacca gattgcagag ctgaaaaaga tatgtgaaca     60

 aagtacggaa tctctaaata atgactggga aaaaaagctt cacaatgctg tagcagaa      118                                                                 
 atg gaa cag gaa aag ttt gat ctt caa aag caa cac act gaa aac att      166
 Met Glu Gln Glu Lys Phe Asp Leu Gln Lys Gln His Thr Glu Asn Ile
   1               5                  10                  15

 caa gaa ttg ctt gag gat aca aat gtg cgt ctg aat aaa atg gag agt      214
 Gln Glu Leu Leu Glu Asp Thr Asn Val Arg Leu Asn Lys Met Glu Ser
              20                  25                  30

 gaa tac atg gcg caa aca cag tcc aca aac cac atg atc aaa gaa ctg      262
 Glu Tyr Met Ala Gln Thr Gln Ser Thr Asn His Met Ile Lys Glu Leu
          35                  40                  45

 gag gcc cgt gtc cag cag ctg act gga gaa gca gag aac agt aat tta      310
 Glu Ala Arg Val Gln Gln Leu Thr Gly Glu Ala Glu Asn Ser Asn Leu
      50                  55                  60

 cag agg cag aaa tta att caa gaa aaa gca gaa ctt gaa aga tgt tac      358
 Gln Arg Gln Lys Leu Ile Gln Glu Lys Ala Glu Leu Glu Arg Cys Tyr
  65                  70                  75                  80

 cag ata acg tgt agt gaa tta caa gaa gta aag gca agg cgt aac aca      406
 Gln Ile Thr Cys Ser Glu Leu Gln Glu Val Lys Ala Arg Arg Asn Thr
                  85                  90                  95

 ctg cat aaa gag aag gac cat ctt gta aat gat tat gag caa aac atg      454
 Leu His Lys Glu Lys Asp His Leu Val Asn Asp Tyr Glu Gln Asn Met
             100                 105                 110

 aaa ctg tta caa acc aaa tat gat gct gat ata aac ctt cta aaa caa      502
 Lys Leu Leu Gln Thr Lys Tyr Asp Ala Asp Ile Asn Leu Leu Lys Gln
         115                 120                 125

 gaa cat gct ctt tca gct tct aag gca tct agt atg att gaa gaa tta      550
 Glu His Ala Leu Ser Ala Ser Lys Ala Ser Ser Met Ile Glu Glu Leu
     130                 135                 140

 gag cag aat gtc tgt caa tta aaa cag cag tta cag gaa tca gaa ctt      598
 Glu Gln Asn Val Cys Gln Leu Lys Gln Gln Leu Gln Glu Ser Glu Leu
 145                 150                 155                 160

 caa aga aag caa caa cta agg gat caa gaa aat aag ttt cag atg gag      646
 Gln Arg Lys Gln Gln Leu Arg Asp Gln Glu Asn Lys Phe Gln Met Glu
                 165                 170                 175

 aaa agt cat cta aaa cac atc tat gaa aaa aag gct cat gac ttg cag      694
 Lys Ser His Leu Lys His Ile Tyr Glu Lys Lys Ala His Asp Leu Gln
             180                 185                 190

 agt gaa ctt gat aaa gga aaa gaa gat act caa aag aaa att cat aaa      742
 Ser Glu Leu Asp Lys Gly Lys Glu Asp Thr Gln Lys Lys Ile His Lys
         195                 200                 205

 ttt gag gaa gct ttg aag gaa aaa gag gag cag cta act cgt gtg act      790
 Phe Glu Glu Ala Leu Lys Glu Lys Glu Glu Gln Leu Thr Arg Val Thr
     210                 215                 220

 gaa gtt cag agg ttg cag gcc cag cag gca gat gcc gct ctg gaa gag      838
 Glu Val Gln Arg Leu Gln Ala Gln Gln Ala Asp Ala Ala Leu Glu Glu
 225                 230                 235                 240

 ttt aag cgg cag gtg gaa ctg aac tca gag aaa gtc tat gct gaa atg      886
 Phe Lys Arg Gln Val Glu Leu Asn Ser Glu Lys Val Tyr Ala Glu Met
                 245                 250                 255

 aaa gag cag atg gaa aaa gtg gag gca gat cta act aga tcc aaa tct      934
 Lys Glu Gln Met Glu Lys Val Glu Ala Asp Leu Thr Arg Ser Lys Ser
             260                 265                 270

 ctt cgt gag aaa caa tca aag gag ttt tta tgg caa ctg gag gac atc      982
 Leu Arg Glu Lys Gln Ser Lys Glu Phe Leu Trp Gln Leu Glu Asp Ile
         275                 280                 285

 aga cag cgg tat gaa caa cag ata gta gag ctg aag ctg gag cat gaa     1030
 Arg Gln Arg Tyr Glu Gln Gln Ile Val Glu Leu Lys Leu Glu His Glu
     290                 295                 300

 cag gag aag acg cac cta tta cag cag cat aac gca gag aag gat agc     1078
 Gln Glu Lys Thr His Leu Leu Gln Gln His Asn Ala Glu Lys Asp Ser
 305                 310                 315                 320

 cta gtc cga gac cat gaa cgg gaa att gaa aac ctg gaa aaa cag ctt     1126
 Leu Val Arg Asp His Glu Arg Glu Ile Glu Asn Leu Glu Lys Gln Leu
                 325                 330                 335

 cgc gct gcc aat atg gag cac gaa aat caa att cag gag ttc aag aaa     1174
 Arg Ala Ala Asn Met Glu His Glu Asn Gln Ile Gln Glu Phe Lys Lys
             340                 345                 350

 cga gat gca cag gtt att gcc gac atg gag gcc cag gtt cac aag ttg     1222
 Arg Asp Ala Gln Val Ile Ala Asp Met Glu Ala Gln Val His Lys Leu
         355                 360                 365

 aga gaa gaa ttg atc aat gtg aac tca cag cgg aaa cag cag ctg gta     1270
 Arg Glu Glu Leu Ile Asn Val Asn Ser Gln Arg Lys Gln Gln Leu Val
     370                 375                 380

 gag ctt ggt ctt ctt cgt gaa gag gaa aag caa agg gct aca agg gaa     1318
 Glu Leu Gly Leu Leu Arg Glu Glu Glu Lys Gln Arg Ala Thr Arg Glu
 385                 390                 395                 400

 cat gag att gtc gtc aat aaa ctg aag gct gaa tca gaa aag atg aaa     1366
 His Glu Ile Val Val Asn Lys Leu Lys Ala Glu Ser Glu Lys Met Lys
                 405                 410                 415

 ata gag ctg aaa aag act cat gct gct gag aca gag atg aca ctg gaa     1414
 Ile Glu Leu Lys Lys Thr His Ala Ala Glu Thr Glu Met Thr Leu Glu
             420                 425                 430

 aag gcc aac agc aag ctg aag cag att gag aag gaa tac act cag aag     1462
 Lys Ala Asn Ser Lys Leu Lys Gln Ile Glu Lys Glu Tyr Thr Gln Lys
         435                 440                 445

 ctt gcc aaa tct tca cag atc ata gca gaa ctt cag aca acc att tcc     1510
 Leu Ala Lys Ser Ser Gln Ile Ile Ala Glu Leu Gln Thr Thr Ile Ser
     450                 455                 460

 tct ctg aaa gaa gag aac agc cag cag cag ctt gct gca gaa agg cgg     1558
 Ser Leu Lys Glu Glu Asn Ser Gln Gln Gln Leu Ala Ala Glu Arg Arg
 465                 470                 475                 480

 ctc cag gat gtt aga caa aag ttt gaa gat gag aag aag cag ctg att     1606
 Leu Gln Asp Val Arg Gln Lys Phe Glu Asp Glu Lys Lys Gln Leu Ile
                 485                 490                 495

 aga gat aat gac caa gca atc aag gtt tta caa gat gaa tta gaa aac     1654
 Arg Asp Asn Asp Gln Ala Ile Lys Val Leu Gln Asp Glu Leu Glu Asn
             500                 505                 510

 cgt tct aat cag gtg cga tgt gca gag aaa aaa tta caa cac aaa gaa     1702
 Arg Ser Asn Gln Val Arg Cys Ala Glu Lys Lys Leu Gln His Lys Glu
         515                 520                 525

 ttg gag tca cag gaa cag ata act tac ata cga caa gaa tat gaa aca     1750
 Leu Glu Ser Gln Glu Gln Ile Thr Tyr Ile Arg Gln Glu Tyr Glu Thr
     530                 535                 540

 aaa ttg aaa gga ttg atg cca gca tcc cta aga caa gaa ctt gaa gac     1798
 Lys Leu Lys Gly Leu Met Pro Ala Ser Leu Arg Gln Glu Leu Glu Asp
 545                 550                 555                 560

 acc att tcc tcc cta aaa tca cag gtt aat ttt ctg caa aag aga gct     1846
 Thr Ile Ser Ser Leu Lys Ser Gln Val Asn Phe Leu Gln Lys Arg Ala
                 565                 570                 575

 tcc atc ctt cag gaa gaa ctg act aca tat caa ggc aga agg taa ctg     1894
 Ser Ile Leu Gln Glu Glu Leu Thr Thr Tyr Gln Gly Arg Arg 
             580                 585                 590

 cacgagagaa tgcaacggat gcaatttcca ggctgtgctg tggacttctt ccagcaggtt   1954

 tgaagatttg gatattgtaa actgtgagat cagtggcatt ttttaaatcc ttaaatgtaa   2014

 ttaagatcat aaaaacatgc atcattcata cactagtggg gtggttttat ttgtgtctgc   2074

 ctaagttatt tttttaacat tcctttattt ccgattttca tgtttgtgtg catttgagta   2134

 tgtgctgaga actgcttata ttgggcaaag tgatttccta tgatatgcct tgttaatcct   2194

 tttgcataga attttaccag ttgcgtacga tcaaaatcac gtttgtagta tcatatcaaa   2254

 aattctaacc tgtttacatt ggtctccacg gccgtggcgc ctatggaacc caaaaagtgc   2314

 tctggacctt taaaaaagaa aaaaacatgg cctacgtggc cctcagcgac ggagcatctg   2374

 ggtccctgta ctttaattcc gggttattcc cgcgctcccc cccctcgatc atctgcccgt   2434

 tctccaatct gaccgcagcg gccgctacct gctctcccaa ggcgagacaa caggtgtcac   2494

 atgccgcggg cggcatcccc gcaaccccac tccccactca tctggtccgc tatagccccg   2554

 gacaccccaa gagccccgcc gcgtcgatcg ctgatcacta gacacaccac catacataca   2614

 a                                                                   2615




      <210> 44
      <211> 426
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(426)

      <400> 44
  atg gcg gac gag gag aaa ctg ccg cct ggc tgg gaa aag cgc atg agc      48
  Met Ala Asp Glu Glu Lys Leu Pro Pro Gly Trp Glu Lys Arg Met Ser
    1               5                  10                  15

 cgc ccc tca ggc cga ggg tac tac ttc aac cac atc act aac ccc agc       96
 Arg Pro Ser Gly Arg Gly Tyr Tyr Phe Asn His Ile Thr Asn Pro Ser
              20                  25                  30

 cag tgg gag cgg ccc agc ggg aac agc agc agt ggc ggc aaa atc tgg      144
 Gln Trp Glu Arg Pro Ser Gly Asn Ser Ser Ser Gly Gly Lys Ile Trp
          35                  40                  45

 cag ggg gag ccc gcc agg gaa atc acc cgg acc aag gag gag gcc ctg      192
 Gln Gly Glu Pro Ala Arg Glu Ile Thr Arg Thr Lys Glu Glu Ala Leu
      50                  55                  60

 gag ctg atc agc ggc tac atc cag aag atc aag gca gga gag aag gac      240
 Glu Leu Ile Ser Gly Tyr Ile Gln Lys Ile Lys Ala Gly Glu Lys Asp
  65                  70                  75                  80

 ttt gag tct ccg gcc tca caa ttc agc gac tgc agc tcg gcc aag gcc      288
 Phe Glu Ser Pro Ala Ser Gln Phe Ser Asp Cys Ser Ser Ala Lys Ala
                  85                  90                  95

 agg gga gac ctg ggt gcc ttc agc aaa ggt cag atg cag aag cca ttt      336
 Arg Gly Asp Leu Gly Ala Phe Ser Lys Gly Gln Met Gln Lys Pro Phe
             100                 105                 110

 gaa gac ccc tgg ttt gcg cgg cgg acg ggg gag atg agc ggg aca gtg      384
 Glu Asp Pro Trp Phe Ala Arg Arg Thr Gly Glu Met Ser Gly Thr Val
         115                 120                 125

 ttc acg gat tcc ggc atc cac gtc att gtc cgc acg gag tga              426
 Phe Thr Asp Ser Gly Ile His Val Ile Val Arg Thr Glu 
     130                 135                 140





      <210> 45
      <211> 787
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (100)..(621)

      <400> 45
 ggaagggagg cagcccaggc tcctatctca tctcccagac gccacgtctc tcggtttctt     60

 cttagatcac tcctctgcca aagatcccaa caagacaac   atg gct ccc aag aag     114
                                              Met Ala Pro Lys Lys
                                                1               5

 cct gag cct aag aag gag gca gcc aag cca gct cca gct cca gct cca      162
 Pro Glu Pro Lys Lys Glu Ala Ala Lys Pro Ala Pro Ala Pro Ala Pro
                  10                  15                  20

 gcc cct gca cca gcc cct gcc cca gct cct gag gct ccc aag gaa cct      210
 Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Glu Ala Pro Lys Glu Pro
              25                  30                  35

 gcc ttt gac ccc aag agt gta aag ata gac ttc act gcc gac cag att      258
 Ala Phe Asp Pro Lys Ser Val Lys Ile Asp Phe Thr Ala Asp Gln Ile
          40                  45                  50

 gaa gag ttc aaa gag gcc ttt tca ttg ttt gac cgg acc ccg act gga      306
 Glu Glu Phe Lys Glu Ala Phe Ser Leu Phe Asp Arg Thr Pro Thr Gly
      55                  60                  65

 gag atg aag atc acc tac ggc cag tgc ggg gat gta ctg cgg gcc ctg      354
 Glu Met Lys Ile Thr Tyr Gly Gln Cys Gly Asp Val Leu Arg Ala Leu
  70                  75                  80                  85

 ggc cag aac cct acc aat gcc gag gtg ctg cgt gtg ctg ggc aag ccc      402
 Gly Gln Asn Pro Thr Asn Ala Glu Val Leu Arg Val Leu Gly Lys Pro
                  90                  95                 100

 aag cct gaa gag atg aat gtc aag atg ctg gac ttt gag acg ttc ttg      450
 Lys Pro Glu Glu Met Asn Val Lys Met Leu Asp Phe Glu Thr Phe Leu
             105                 110                 115

 ccc atc ctg cag cac att tcc cgc aac aag gag cag ggc acc tat gag      498
 Pro Ile Leu Gln His Ile Ser Arg Asn Lys Glu Gln Gly Thr Tyr Glu
         120                 125                 130

 gac ttc gtg gag ggc ctg cgt gtc ttt gac aag gag agc aat ggc acg      546
 Asp Phe Val Glu Gly Leu Arg Val Phe Asp Lys Glu Ser Asn Gly Thr
     135                 140                 145

 gtc atg ggt ggg caa gag gat gcc aat ggc tgc atc aat tat gaa gcc      594
 Val Met Gly Gly Gln Glu Asp Ala Asn Gly Cys Ile Asn Tyr Glu Ala
 150                 155                 160                 165

 ttt gtc aag cac atc atg tca ggg tga agcag agtcttccag gtgcctgccc      646
 Phe Val Lys His Ile Met Ser Gly 
                 170

 ttgctttagc ataccagggt gagttaagag aggccccgct ggtgagctga gatgagtctc    706

 gacttatcac cacaccactg ccagactaca gcctcctgtt ataacagctc tacacgcagc    766

 tggctctgga tctgaaaaaa a                                              787




      <210> 46
      <211> 1008
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1008)

      <400> 46
  atg ggg gtg tcc ttt gtc gct cct ggc ggg aac ccc ggc ccc acc ccc      48
  Met Gly Val Ser Phe Val Ala Pro Gly Gly Asn Pro Gly Pro Thr Pro
    1               5                  10                  15

 aac tcc acg cct ccc att acc ccc aga tct ctg gac cgg att cgt ccc       96
 Asn Ser Thr Pro Pro Ile Thr Pro Arg Ser Leu Asp Arg Ile Arg Pro
              20                  25                  30

 att ctc gtc ctc atg gtg gac aag aaa ctg gtg gtg gtt ttc gga ggc      144
 Ile Leu Val Leu Met Val Asp Lys Lys Leu Val Val Val Phe Gly Gly
          35                  40                  45

 aca ggt gcc cag ggt ggc tcc gtg gcc cgc aca ctc ctg gaa gat ggg      192
 Thr Gly Ala Gln Gly Gly Ser Val Ala Arg Thr Leu Leu Glu Asp Gly
      50                  55                  60

 aca ttc aag gtt cga gtg gtg acc cga aac cct agg aag aag gca gca      240
 Thr Phe Lys Val Arg Val Val Thr Arg Asn Pro Arg Lys Lys Ala Ala
  65                  70                  75                  80

 aag gag ctg agg ctg caa ggt gca gaa gta gtg cag gga gac caa gat      288
 Lys Glu Leu Arg Leu Gln Gly Ala Glu Val Val Gln Gly Asp Gln Asp
                  85                  90                  95

 gac cag gtc atc atg gag ctg gcc ctg aat ggg gct tac gcc acc ttc      336
 Asp Gln Val Ile Met Glu Leu Ala Leu Asn Gly Ala Tyr Ala Thr Phe
             100                 105                 110

 atc gtg acc aat tac tgg gag agc tgc agc cag gag cag gag gtc aag      384
 Ile Val Thr Asn Tyr Trp Glu Ser Cys Ser Gln Glu Gln Glu Val Lys
         115                 120                 125

 cag ggg aag ctg ctc gct gat ctg gcc agg cgc ctg ggc ctc cac tat      432
 Gln Gly Lys Leu Leu Ala Asp Leu Ala Arg Arg Leu Gly Leu His Tyr
     130                 135                 140

 gtg gtc tac agc ggc ctg gag aac atc aag aag ctg acg gca ggg aga      480
 Val Val Tyr Ser Gly Leu Glu Asn Ile Lys Lys Leu Thr Ala Gly Arg
 145                 150                 155                 160

 ttg gcc gcc gcg cac ttt gac ggc aaa ggg gag gtg gag gaa tat ttc      528
 Leu Ala Ala Ala His Phe Asp Gly Lys Gly Glu Val Glu Glu Tyr Phe
                 165                 170                 175

 cgg gac att ggc gtt ccc atg acc agt gtg cgg ctg ccc tgc tat ttt      576
 Arg Asp Ile Gly Val Pro Met Thr Ser Val Arg Leu Pro Cys Tyr Phe
             180                 185                 190

 gag aac ctc ctc tcc cac ttc ttg ccc cag aaa gcc cca gac gga aag      624
 Glu Asn Leu Leu Ser His Phe Leu Pro Gln Lys Ala Pro Asp Gly Lys
         195                 200                 205

 agc tac ttg ctg agc ttg ccc aca ggt gac gtt ccc atg gat ggc atg      672
 Ser Tyr Leu Leu Ser Leu Pro Thr Gly Asp Val Pro Met Asp Gly Met
     210                 215                 220

 tcc gtg tct gac ctg ggt cct gtg gtg ctc agc ctt ttg aag atg cca      720
 Ser Val Ser Asp Leu Gly Pro Val Val Leu Ser Leu Leu Lys Met Pro
 225                 230                 235                 240

 gaa aaa tac gtc ggc cag aac atc ggg ctg agc act tgc agg cac acg      768
 Glu Lys Tyr Val Gly Gln Asn Ile Gly Leu Ser Thr Cys Arg His Thr
                 245                 250                 255

 gcc gag gag tac gct gcc ctg ctc acc aag cac acc cgc aag gtc gtg      816
 Ala Glu Glu Tyr Ala Ala Leu Leu Thr Lys His Thr Arg Lys Val Val
             260                 265                 270

 cac gat gcc aag atg act cct gag gac tac gaa aag ctt ggc ttt ccc      864
 His Asp Ala Lys Met Thr Pro Glu Asp Tyr Glu Lys Leu Gly Phe Pro
         275                 280                 285

 ggt gcc cgg gac ctg gcc aac atg ttc cgt ttc tat gcc ctg aga ccc      912
 Gly Ala Arg Asp Leu Ala Asn Met Phe Arg Phe Tyr Ala Leu Arg Pro
     290                 295                 300

 gac cgt gac atc gag ctg acc ctg aga ctc aac ccc aag gcc ctg acg      960
 Asp Arg Asp Ile Glu Leu Thr Leu Arg Leu Asn Pro Lys Ala Leu Thr
 305                 310                 315                 320

 ctg gac cag tgg ctg gaa cag cac aaa ggg gac ttc aac ctg ctg tga     1008
 Leu Asp Gln Trp Leu Glu Gln His Lys Gly Asp Phe Asn Leu Leu 
                 325                 330                 335





      <210> 47
      <211> 1506
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1506)

      <400> 47
  atg cag gtt tgc agc cag ccc caa agg ggg tgt gtg cgc gag cag agc      48
  Met Gln Val Cys Ser Gln Pro Gln Arg Gly Cys Val Arg Glu Gln Ser
    1               5                  10                  15

 gct ata aat acg gcg cct ccc agt gcc cac aac gcg gcg tcg cca gga       96
 Ala Ile Asn Thr Ala Pro Pro Ser Ala His Asn Ala Ala Ser Pro Gly
              20                  25                  30

 gga gcg cgc ggg cac agg gtg ccg ctg acc gag gcg tgc aaa gac tcc      144
 Gly Ala Arg Gly His Arg Val Pro Leu Thr Glu Ala Cys Lys Asp Ser
          35                  40                  45

 aga att gga ggc atg atg aag act ctg ctg ctg ttt gtg ggg ctg ctg      192
 Arg Ile Gly Gly Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu
      50                  55                  60

 ctg acc tgg gag agt ggg cag gtc ctg ggg gac cag acg gtc tca gac      240
 Leu Thr Trp Glu Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp
  65                  70                  75                  80

 aat gag ctc cag gaa atg tcc aat cag gga agt aag tac gtc aat aag      288
 Asn Glu Leu Gln Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys
                  85                  90                  95

 gaa att caa aat gct gtc aac ggg gtg aaa cag ata aag act ctc ata      336
 Glu Ile Gln Asn Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile
             100                 105                 110

 gaa aaa aca aac gaa gag cgc aag aca ctg ctc agc aac cta gaa gaa      384
 Glu Lys Thr Asn Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu
         115                 120                 125

 gcc aag aag aag aaa gag gat gcc cta aat gag acc agg gaa tca gag      432
 Ala Lys Lys Lys Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu
     130                 135                 140

 aca aag ctg aag gag ctc cca gga gtg tgc aat gag acc atg atg gcc      480
 Thr Lys Leu Lys Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala
 145                 150                 155                 160

 ctc tgg gaa gag tgt aag ccc tgc ctg aaa cag acc tgc atg aag ttc      528
 Leu Trp Glu Glu Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe
                 165                 170                 175

 tac gca cgc gtc tgc aga agt ggc tca ggc ctg gtt ggc cgc cag ctt      576
 Tyr Ala Arg Val Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu
             180                 185                 190

 gag gag ttc ctg aac cag agc tcg ccc ttc tac ttc tgg atg aat ggt      624
 Glu Glu Phe Leu Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly
         195                 200                 205

 gac cgc atc gac tcc ctg ctg gag aac gac cgg cag cag acg cac atg      672
 Asp Arg Ile Asp Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met
     210                 215                 220

 ctg gat gtc atg cag gac cac ttc agc cgc gcg tcc agc atc ata gac      720
 Leu Asp Val Met Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp
 225                 230                 235                 240

 gag ctc ttc cag gac agg ttc ttc acc cgg gag ccc cag gat acc tac      768
 Glu Leu Phe Gln Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr
                 245                 250                 255

 cac tac ctg ccc ttc agc ctg ccc cac cgg agg cct cac ttc ttc ttt      816
 His Tyr Leu Pro Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe
             260                 265                 270

 ccc aag tcc cgc atc gtc cgc agc ttg atg ccc ttc tct ccg tac gag      864
 Pro Lys Ser Arg Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu
         275                 280                 285

 ccc ctg aac ttc cac gcc atg ttc cag ccc ttc ctt gag atg ata cac      912
 Pro Leu Asn Phe His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His
     290                 295                 300

 gag gct cag cag gcc atg gac atc cac ttc cac agc ccg gcc ttc cag      960
 Glu Ala Gln Gln Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln
 305                 310                 315                 320

 cac ccg cca aca gaa ttc ata cga gaa ggc gac gat gac cgg act gtg     1008
 His Pro Pro Thr Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val
                 325                 330                 335

 tgc cgg gag atc cgc cac aac tcc acg ggc tgc ctg cgg atg aag gac     1056
 Cys Arg Glu Ile Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp
             340                 345                 350

 cag tgt gac aag tgc cgg gag atc ttg tct gtg gac tgt tcc acc aac     1104
 Gln Cys Asp Lys Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn
         355                 360                 365

 aac ccc tcc cag gct aag ctg cgg cgg gag ctc gac gaa tcc ctc cag     1152
 Asn Pro Ser Gln Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln
     370                 375                 380

 gtc gct gag agg ttg acc agg aaa tac aac gag ctg cta aag tcc tac     1200
 Val Ala Glu Arg Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr
 385                 390                 395                 400

 cag tgg aag atg ctc aac acc tcc tcc ttg ctg gag cag ctg aac gag     1248
 Gln Trp Lys Met Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu
                 405                 410                 415

 cag ttt aac tgg gtg tcc cgg ctg gca aac ctc acg caa ggc gaa gac     1296
 Gln Phe Asn Trp Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp
             420                 425                 430

 cag tac tat ctg cgg gtc acc acg gtg gct tcc cac act tct gac tcg     1344
 Gln Tyr Tyr Leu Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser
         435                 440                 445

 gac gtt cct tcc ggt gtc act gag gtg gtc gtg aag ctc ttt gac tct     1392
 Asp Val Pro Ser Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser
     450                 455                 460

 gat ccc atc act gtg acg gtc cct gta gaa gtc tcc agg aag aac cct     1440
 Asp Pro Ile Thr Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro
 465                 470                 475                 480

 aaa ttt atg gag acc gtg gcg gag aaa gcg ctg cag gaa tac cgc aaa     1488
 Lys Phe Met Glu Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys
                 485                 490                 495

 aag cac cgg gag gag tga                                             1506
 Lys His Arg Glu Glu 
             500





      <210> 48
      <211> 630
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (116)..(376)

      <400> 48
 ctcgatttga tagctgttac gaccgccgta ccggaccgga attcccgggt cgacccacgc     60

 gtccggtggc ggcggtggcg gacccttggg gtctggacgc aacggcggcg ggagc atg     118
                                                              Met
                                                                1

 aac gcc cct cca gcc ttc gag tcg ttc ttg ctc ttc gag ggc gag aaa      166
 Asn Ala Pro Pro Ala Phe Glu Ser Phe Leu Leu Phe Glu Gly Glu Lys
               5                  10                  15

 caa ctc cta aaa gac ccg caa gtg cta ttt gct ggc tac aaa gtc ccc      214
 Gln Leu Leu Lys Asp Pro Gln Val Leu Phe Ala Gly Tyr Lys Val Pro
          20                  25                  30

 cac ccc ttg gag cac aag atc atc atc cga gtg cag acc acg ccg gac      262
 His Pro Leu Glu His Lys Ile Ile Ile Arg Val Gln Thr Thr Pro Asp
      35                  40                  45

 tac agc ccc cag gaa gcc ttt acc aac gcc atc acc gac ctc atc agt      310
 Tyr Ser Pro Gln Glu Ala Phe Thr Asn Ala Ile Thr Asp Leu Ile Ser
  50                  55                  60                  65

 gag ctg tcc ctg ctg gag gag cgc ttt cgg gtg gcc ata aaa gac aag      358
 Glu Leu Ser Leu Leu Glu Glu Arg Phe Arg Val Ala Ile Lys Asp Lys
                  70                  75                  80

 cag gaa gga att gag tag gggcca gagggggctc tgctcggcct gtgagccccg      412
 Gln Glu Gly Ile Glu 
              85

 ttcctacctg tgcctgaccc tccgctccag gtaccacacc gaggagagcg gccggtccca    472

 gccatggccc gccttgtggc cacccctcac cctgacaccg acgtgtcctg tacatagatt    532

 aggttttata ttcctaataa agtatagcgg aagagaaaaa aaaaaaaaaa aaaaaaaaaa    592

 aaaaaaaaaa aaaaaaaaga tatgcggccg caagctta                            630




      <210> 49
      <211> 1677
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (127)..(1671)

      <400> 49
 cggcacgaga acccgccggg atcaaagtgt accagtcggc agcatgggtc atgtgtctcc     60

 agctcttccc agcacaacct caccctcctc agggctctga gggggcggag aggacaggcc    120

 agagcg   atg agg ctg gag tgg gga cct agg cca gcc gca ctg ccg tgg     168
          Met Arg Leu Glu Trp Gly Pro Arg Pro Ala Ala Leu Pro Trp
            1               5                  10

 ccc gct ggg atg tgt gct gca gaa cgt gcg gag gga gcc ttc acc ctc      216
 Pro Ala Gly Met Cys Ala Ala Glu Arg Ala Glu Gly Ala Phe Thr Leu
  15                  20                  25                  30

 cag agc gtg gcc cag cca atg cgc ccc att gct tcc aca gct acg aaa      264
 Gln Ser Val Ala Gln Pro Met Arg Pro Ile Ala Ser Thr Ala Thr Lys
                  35                  40                  45

 tgt ggg aat tgt gga ccc ggc tac tcc acc cct ctg gag gcc atg aaa      312
 Cys Gly Asn Cys Gly Pro Gly Tyr Ser Thr Pro Leu Glu Ala Met Lys
              50                  55                  60

 gga ccc agg gaa gag atc gtc tac ctg ccc tgc att tac cga aac aca      360
 Gly Pro Arg Glu Glu Ile Val Tyr Leu Pro Cys Ile Tyr Arg Asn Thr
          65                  70                  75

 ggc act gag gcc cca gat tat ctg gcc act gtg gat gtt gac ccc aag      408
 Gly Thr Glu Ala Pro Asp Tyr Leu Ala Thr Val Asp Val Asp Pro Lys
      80                  85                  90

 tct ccc cag tat tgc cag gtc atc cac cgg ctg ccc atg ccc aac ctg      456
 Ser Pro Gln Tyr Cys Gln Val Ile His Arg Leu Pro Met Pro Asn Leu
  95                 100                 105                 110

 aag gac gag ctg cat aac tca gga tgg aac acc tgc agc agc tgc ttc      504
 Lys Asp Glu Leu His Asn Ser Gly Trp Asn Thr Cys Ser Ser Cys Phe
                 115                 120                 125

 ggt gat agc acc aag tcg cgc acc aag ctg gtg ctg ccc agt ctc atc      552
 Gly Asp Ser Thr Lys Ser Arg Thr Lys Leu Val Leu Pro Ser Leu Ile
             130                 135                 140

 tcc tct cgc atc tat gtg gtg gac gtg ggc tct gag ccc cgg gcc cca      600
 Ser Ser Arg Ile Tyr Val Val Asp Val Gly Ser Glu Pro Arg Ala Pro
         145                 150                 155

 aag ctg cac aag gtc att gag ccc aag gac atc cat gcc aag tgc gaa      648
 Lys Leu His Lys Val Ile Glu Pro Lys Asp Ile His Ala Lys Cys Glu
     160                 165                 170

 ctg gcc ttt ctc cac acc agc cac tgc ctg gcc agc ggg gaa gtg atg      696
 Leu Ala Phe Leu His Thr Ser His Cys Leu Ala Ser Gly Glu Val Met
 175                 180                 185                 190

 atc agc tcc ctg gga gac gtc aag ggc aat ggc aaa ggg ggt ttt gtg      744
 Ile Ser Ser Leu Gly Asp Val Lys Gly Asn Gly Lys Gly Gly Phe Val
                 195                 200                 205

 ctg ctg gat ggg gag acg ttc gag gtg aag ggg aca tgg gag aga cct      792
 Leu Leu Asp Gly Glu Thr Phe Glu Val Lys Gly Thr Trp Glu Arg Pro
             210                 215                 220

 ggg ggt gct gca ccg ttg ggc tat gac ttc tgg tac cag cct cga cac      840
 Gly Gly Ala Ala Pro Leu Gly Tyr Asp Phe Trp Tyr Gln Pro Arg His
         225                 230                 235

 aat gtc atg atc agc act gag tgg gca gct ccc aat gtc tta cga gat      888
 Asn Val Met Ile Ser Thr Glu Trp Ala Ala Pro Asn Val Leu Arg Asp
     240                 245                 250

 ggc ttc aac ccc gct gat gtg gag gct gga ctg tac ggg agc cac tta      936
 Gly Phe Asn Pro Ala Asp Val Glu Ala Gly Leu Tyr Gly Ser His Leu
 255                 260                 265                 270

 tat gta tgg gac tgg cag cgc cat gag att gtg cag acc ctg tct cta      984
 Tyr Val Trp Asp Trp Gln Arg His Glu Ile Val Gln Thr Leu Ser Leu
                 275                 280                 285

 aaa gat ggg ctt att ccc ttg gag atc cgc ttc ctg cac aac cca gac     1032
 Lys Asp Gly Leu Ile Pro Leu Glu Ile Arg Phe Leu His Asn Pro Asp
             290                 295                 300

 gct gcc caa ggc ttt gtg ggc tgc gca ctc agc tcc acc atc cag cgc     1080
 Ala Ala Gln Gly Phe Val Gly Cys Ala Leu Ser Ser Thr Ile Gln Arg
         305                 310                 315

 ttc tac aag aac gag gga ggt aca tgg tca gtg gag aag gtg atc cag     1128
 Phe Tyr Lys Asn Glu Gly Gly Thr Trp Ser Val Glu Lys Val Ile Gln
     320                 325                 330

 gtg ccc ccc aag aaa gtg aag ggc tgg ctg ctg ccc gaa atg cca ggc     1176
 Val Pro Pro Lys Lys Val Lys Gly Trp Leu Leu Pro Glu Met Pro Gly
 335                 340                 345                 350

 ctg atc acc gac atc ctg ctc tcc ctg gac gac cgc ttc ctc tac ttc     1224
 Leu Ile Thr Asp Ile Leu Leu Ser Leu Asp Asp Arg Phe Leu Tyr Phe
                 355                 360                 365

 agc aac tgg ctg cat ggg gac ctg agg cag tat gac atc tct gac cca     1272
 Ser Asn Trp Leu His Gly Asp Leu Arg Gln Tyr Asp Ile Ser Asp Pro
             370                 375                 380

 cag aga ccc cgc ctc aca gga cag ctc ttc ctc gga ggc agc att gtt     1320
 Gln Arg Pro Arg Leu Thr Gly Gln Leu Phe Leu Gly Gly Ser Ile Val
         385                 390                 395

 aag gga ggc cct gtg caa gtg ctg gag gac gag gaa cta aag tcc cag     1368
 Lys Gly Gly Pro Val Gln Val Leu Glu Asp Glu Glu Leu Lys Ser Gln
     400                 405                 410

 cca gag ccc cta gtg gtc aag gga aaa cgg gtg gct gga ggc cct cag     1416
 Pro Glu Pro Leu Val Val Lys Gly Lys Arg Val Ala Gly Gly Pro Gln
 415                 420                 425                 430

 atg atc cag ctc agc ctg gat ggc aag cgc ctc tac atc acc acg tcg     1464
 Met Ile Gln Leu Ser Leu Asp Gly Lys Arg Leu Tyr Ile Thr Thr Ser
                 435                 440                 445

 ctg tac agt gcc tgg gaa aag cag ttt tac cct gat ctc atc agg gaa     1512
 Leu Tyr Ser Ala Trp Glu Lys Gln Phe Tyr Pro Asp Leu Ile Arg Glu
             450                 455                 460

 ggc tct gta atg ctg cag gtt gat gta gac aca gta aaa gga ggg ctg     1560
 Gly Ser Val Met Leu Gln Val Asp Val Asp Thr Val Lys Gly Gly Leu
         465                 470                 475

 aag ttg aac ccc aac tgc ctg gtg gac ttc ggg aag gag ccc ctt ggc     1608
 Lys Leu Asn Pro Asn Cys Leu Val Asp Phe Gly Lys Glu Pro Leu Gly
     480                 485                 490

 cca gcc ctg gct cac gag ctt cgc tac cct ggg ggc gat tgt agc tct     1656
 Pro Ala Leu Ala His Glu Leu Arg Tyr Pro Gly Gly Asp Cys Ser Ser
 495                 500                 505                 510

 gac atc tgg att tga aggctc                                          1677
 Asp Ile Trp Ile 






      <210> 50
      <211> 1878
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1878)

      <400> 50
  atg aaa tgc aag aga gcc cct tat aag agc tac cga aat tct tcc tat      48
  Met Lys Cys Lys Arg Ala Pro Tyr Lys Ser Tyr Arg Asn Ser Ser Tyr
    1               5                  10                  15

 gaa aat gca cga gaa aac agt caa atg aat gag tct gca cct ggt acc       96
 Glu Asn Ala Arg Glu Asn Ser Gln Met Asn Glu Ser Ala Pro Gly Thr
              20                  25                  30

 tat gtt gtt cag aat cca cac agc tct gaa tta cca acg ctg aat ttc      144
 Tyr Val Val Gln Asn Pro His Ser Ser Glu Leu Pro Thr Leu Asn Phe
          35                  40                  45

 caa gat act gta aac acc ctg acc aac agt cca gcc atc cca ttg gaa      192
 Gln Asp Thr Val Asn Thr Leu Thr Asn Ser Pro Ala Ile Pro Leu Glu
      50                  55                  60

 aca tct gca tgt cag gac ata ccc act tct gcc aat gta caa aat gca      240
 Thr Ser Ala Cys Gln Asp Ile Pro Thr Ser Ala Asn Val Gln Asn Ala
  65                  70                  75                  80

 gag ggt acc aaa tgg gga gag gag gca ttg aaa atg gat ctt gac aat      288
 Glu Gly Thr Lys Trp Gly Glu Glu Ala Leu Lys Met Asp Leu Asp Asn
                  85                  90                  95

 aac ttt tat tca act gag gtg tca gtt tct tcc act gaa aat gct gtc      336
 Asn Phe Tyr Ser Thr Glu Val Ser Val Ser Ser Thr Glu Asn Ala Val
             100                 105                 110

 agt tct gac ctc cgg gca ggg gat gta cct gtt tta tct ttg agt aat      384
 Ser Ser Asp Leu Arg Ala Gly Asp Val Pro Val Leu Ser Leu Ser Asn
         115                 120                 125

 agc agt gag aat gcc gcc tct gtg atc agc tac agt ggc tct gca ccc      432
 Ser Ser Glu Asn Ala Ala Ser Val Ile Ser Tyr Ser Gly Ser Ala Pro
     130                 135                 140

 tcg gtc att gta cac agc agc cag ttt tca tcg gtg atc atg cac agc      480
 Ser Val Ile Val His Ser Ser Gln Phe Ser Ser Val Ile Met His Ser
 145                 150                 155                 160

 aat gcc att gct gcc atg acc agc agc aac cac aga gcc ttt tca gac      528
 Asn Ala Ile Ala Ala Met Thr Ser Ser Asn His Arg Ala Phe Ser Asp
                 165                 170                 175

 cca gct gtc agt cag tcc ctg aaa gat gac agt aag ccc gag cca gat      576
 Pro Ala Val Ser Gln Ser Leu Lys Asp Asp Ser Lys Pro Glu Pro Asp
             180                 185                 190

 aaa gtg ggt agg ttt gca agc aga ccc aaa agc att aag gag aaa aag      624
 Lys Val Gly Arg Phe Ala Ser Arg Pro Lys Ser Ile Lys Glu Lys Lys
         195                 200                 205

 aaa act aca tca cat acc agg gga gaa ata ccg gag gag tca aac tat      672
 Lys Thr Thr Ser His Thr Arg Gly Glu Ile Pro Glu Glu Ser Asn Tyr
     210                 215                 220

 gtt gct gat cct gga gga tca ctg agc aaa acc aca aat att gct gaa      720
 Val Ala Asp Pro Gly Gly Ser Leu Ser Lys Thr Thr Asn Ile Ala Glu
 225                 230                 235                 240

 gaa acc agc aaa att gaa acc tac att gca aaa cct gct ctg ccg gga      768
 Glu Thr Ser Lys Ile Glu Thr Tyr Ile Ala Lys Pro Ala Leu Pro Gly
                 245                 250                 255

 acc tcc aca aat agt aat gtt gca ccc ctt tgc caa ata aca gtg aaa      816
 Thr Ser Thr Asn Ser Asn Val Ala Pro Leu Cys Gln Ile Thr Val Lys
             260                 265                 270

 att gga aac gaa gcc att gtg aaa agg cac att cta gga tct aaa ttg      864
 Ile Gly Asn Glu Ala Ile Val Lys Arg His Ile Leu Gly Ser Lys Leu
         275                 280                 285

 ttt tat aaa aga ggg aga aga ccc aag tat cag atg cag gag gag cct      912
 Phe Tyr Lys Arg Gly Arg Arg Pro Lys Tyr Gln Met Gln Glu Glu Pro
     290                 295                 300

 ttg cca cag ggg aat gac cca gaa ccc agt gga gac agc cca ctc ggg      960
 Leu Pro Gln Gly Asn Asp Pro Glu Pro Ser Gly Asp Ser Pro Leu Gly
 305                 310                 315                 320

 ctt tgc caa tcc gag tgc atg gag atg agt gaa gtg ttc gat gac gca     1008
 Leu Cys Gln Ser Glu Cys Met Glu Met Ser Glu Val Phe Asp Asp Ala
                 325                 330                 335

 agt gac cag gat tcc act gac aaa ccg tgg cgc cct tac tac aac tac     1056
 Ser Asp Gln Asp Ser Thr Asp Lys Pro Trp Arg Pro Tyr Tyr Asn Tyr
             340                 345                 350

 aaa ccc aaa aag aaa tcc aga cag ttg aaa aaa atg agg aaa gtc aac     1104
 Lys Pro Lys Lys Lys Ser Arg Gln Leu Lys Lys Met Arg Lys Val Asn
         355                 360                 365

 tgg agg aag gag cac gga aac agg agc ccg agc cat aaa tgt aaa tac     1152
 Trp Arg Lys Glu His Gly Asn Arg Ser Pro Ser His Lys Cys Lys Tyr
     370                 375                 380

 cca gca gaa ctg gat tgc gcc gtg ggg aag gct cct cag gat aaa ccc     1200
 Pro Ala Glu Leu Asp Cys Ala Val Gly Lys Ala Pro Gln Asp Lys Pro
 385                 390                 395                 400

 ttt gag gaa gaa gaa act aaa gag atg ccc aag ctg cag tgt gaa ctc     1248
 Phe Glu Glu Glu Glu Thr Lys Glu Met Pro Lys Leu Gln Cys Glu Leu
                 405                 410                 415

 tgt gat gga gac aaa gca gtg ggg gct gga aac caa gga agg ccc cac     1296
 Cys Asp Gly Asp Lys Ala Val Gly Ala Gly Asn Gln Gly Arg Pro His
             420                 425                 430

 cga cat ctt act tct cgg cca tat gcc tgc gag ctc tgc gcc aag cag     1344
 Arg His Leu Thr Ser Arg Pro Tyr Ala Cys Glu Leu Cys Ala Lys Gln
         435                 440                 445

 ttc cag agc cct tcc aca ctc aaa atg cac atg aga tgt cac acc ggg     1392
 Phe Gln Ser Pro Ser Thr Leu Lys Met His Met Arg Cys His Thr Gly
     450                 455                 460

 gag aag cca tac cag tgc aag acc tgc gga cgg tgc ttt tcg gtg caa     1440
 Glu Lys Pro Tyr Gln Cys Lys Thr Cys Gly Arg Cys Phe Ser Val Gln
 465                 470                 475                 480

 gga aac tta cag aaa cat gaa cgc atc cac ctg ggc ttg aag gag ttc     1488
 Gly Asn Leu Gln Lys His Glu Arg Ile His Leu Gly Leu Lys Glu Phe
                 485                 490                 495

 gtc tgt cag tat tgc aac aag gca ttc acc ttg aat gag acc ctc aaa     1536
 Val Cys Gln Tyr Cys Asn Lys Ala Phe Thr Leu Asn Glu Thr Leu Lys
             500                 505                 510

 atc cat gaa aga atc cat act gga gaa aag cgt tac cac tgt cag ttc     1584
 Ile His Glu Arg Ile His Thr Gly Glu Lys Arg Tyr His Cys Gln Phe
         515                 520                 525

 tgc ttt cag aga ttt ttg tat ctc tcc acc aaa agg aat cac gag cag     1632
 Cys Phe Gln Arg Phe Leu Tyr Leu Ser Thr Lys Arg Asn His Glu Gln
     530                 535                 540

 agg cat att cgg gag cat aat ggg aag ggc tat gcc tgc ttc cag tgc     1680
 Arg His Ile Arg Glu His Asn Gly Lys Gly Tyr Ala Cys Phe Gln Cys
 545                 550                 555                 560

 ccc aaa att tgc aaa aca gct gct gcc ctt gga atg cac caa aag aaa     1728
 Pro Lys Ile Cys Lys Thr Ala Ala Ala Leu Gly Met His Gln Lys Lys
                 565                 570                 575

 cac tta ttc aaa agc cca agt cag cag gag aaa ata ggt gac gtg tgc     1776
 His Leu Phe Lys Ser Pro Ser Gln Gln Glu Lys Ile Gly Asp Val Cys
             580                 585                 590

 cac gaa aac tca aat ccc ttg gag aat caa cat ttc att ggt tca gaa     1824
 His Glu Asn Ser Asn Pro Leu Glu Asn Gln His Phe Ile Gly Ser Glu
         595                 600                 605

 gac aat gac caa aag gat aac ata caa acc ggt gtg gaa aat gtt gtc     1872
 Asp Asn Asp Gln Lys Asp Asn Ile Gln Thr Gly Val Glu Asn Val Val
     610                 615                 620

 ctt tga                                                             1878
 Leu 
 625





      <210> 51
      <211> 6183
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (393)..(1994)

      <400> 51
 ggttggctcg cgggtaggcg gccccgcccc ccacatccgg gggccggggc cgggctgtgg     60

 gcttgccgcg cgcgggtgag tcaggccggg ttttccctcc gcctttgggg caggcgatcg    120

 agcgccgcgg agcgcgtccc tccctcgcca atccggctcc ggcgccggcg cccgcccgcg    180

 ttttcccggc gcctgccgct ccgccgctcc gacccggcac gcagtcccgg cccgagccga    240

 cgccttgcag gagggttcaa atccgcgcgg gggagctgcg acgcgcaagg gctgcggagc    300

 cgcgggccgg cgagcgcgtc gccaccatga agcagctgcc tgtaccctgt tgaaacttca    360

 tggccacagc cccaggccct gctggcattg cc  atg ggc agc gtg ggc agc ctg     413
                                      Met Gly Ser Val Gly Ser Leu
                                        1               5

 ttg gaa cgg cag gac ttc tcc cct gaa gag ctg cgg gcg gca ctt gcc      461
 Leu Glu Arg Gln Asp Phe Ser Pro Glu Glu Leu Arg Ala Ala Leu Ala
          10                  15                  20

 ggg tct cgg ggc tcc cgc cag cct gat ggg ctc ctc cgg aag ggc ttg      509
 Gly Ser Arg Gly Ser Arg Gln Pro Asp Gly Leu Leu Arg Lys Gly Leu
      25                  30                  35

 ggc cag cgt gag ttc ctc agc tac ctg cac ctc ccc aag aag gac agc      557
 Gly Gln Arg Glu Phe Leu Ser Tyr Leu His Leu Pro Lys Lys Asp Ser
  40                  45                  50                  55

 aag agc acc aag aac acc aag cgg gcc cct cgg aac gag cct gcc gac      605
 Lys Ser Thr Lys Asn Thr Lys Arg Ala Pro Arg Asn Glu Pro Ala Asp
                  60                  65                  70

 tat gcc acc ctc tac tac cgg gaa cat tct cgc gcg ggt gac ttc agc      653
 Tyr Ala Thr Leu Tyr Tyr Arg Glu His Ser Arg Ala Gly Asp Phe Ser
              75                  80                  85

 aag acc tcg ctg cca gaa cgg ggt cgc ttt gac aag tgc cgc att cgc      701
 Lys Thr Ser Leu Pro Glu Arg Gly Arg Phe Asp Lys Cys Arg Ile Arg
          90                  95                 100

 ccc tca gtg ttc aag cct acg gcg ggc aac ggg aaa ggc ttc cta tcc      749
 Pro Ser Val Phe Lys Pro Thr Ala Gly Asn Gly Lys Gly Phe Leu Ser
     105                 110                 115

 atg caa agc ctg gcg tcc cac aaa ggc cag aag ctg tgg cgc agc aat      797
 Met Gln Ser Leu Ala Ser His Lys Gly Gln Lys Leu Trp Arg Ser Asn
 120                 125                 130                 135

 ggc agc ctg cac acg ctg gcc tgc cac ccg ccc ctg agc ccc ggg ccc      845
 Gly Ser Leu His Thr Leu Ala Cys His Pro Pro Leu Ser Pro Gly Pro
                 140                 145                 150

 cgg gcc agc cag gcc cgg gca cag ctg ctg cac gcc ctc agc cta gat      893
 Arg Ala Ser Gln Ala Arg Ala Gln Leu Leu His Ala Leu Ser Leu Asp
             155                 160                 165

 gag ggc ggc cct gag ccc gag ccc agc ctg tcc gac tcc tcc agt ggg      941
 Glu Gly Gly Pro Glu Pro Glu Pro Ser Leu Ser Asp Ser Ser Ser Gly
         170                 175                 180

 ggt agt ttt ggt cgc agt cct ggt act ggc cct agc ccc ttc agc tcc      989
 Gly Ser Phe Gly Arg Ser Pro Gly Thr Gly Pro Ser Pro Phe Ser Ser
     185                 190                 195

 tcc ctt ggc cac ctt aac cac ctc ggg ggc tcc ctg gac cgg gcc tct     1037
 Ser Leu Gly His Leu Asn His Leu Gly Gly Ser Leu Asp Arg Ala Ser
 200                 205                 210                 215

 caa gga ccc aag gag gct ggg cca cca gct gtg ctg agc tgc ctg ccc     1085
 Gln Gly Pro Lys Glu Ala Gly Pro Pro Ala Val Leu Ser Cys Leu Pro
                 220                 225                 230

 gag cca cca ccc ccc tac gag ttc tcc tgc tcc tct gcc gag gaa atg     1133
 Glu Pro Pro Pro Pro Tyr Glu Phe Ser Cys Ser Ser Ala Glu Glu Met
             235                 240                 245

 gga gcc gtg ctg ccc gag acc tgt gag gag ctc aag agg ggc ctt ggc     1181
 Gly Ala Val Leu Pro Glu Thr Cys Glu Glu Leu Lys Arg Gly Leu Gly
         250                 255                 260

 gat gag gac ggc tcc aac ccc ttc acg cag gtg ctg gag gag cgc cag     1229
 Asp Glu Asp Gly Ser Asn Pro Phe Thr Gln Val Leu Glu Glu Arg Gln
     265                 270                 275

 cgg ctg tgg ctg gct gag ctg aag cgc ctg tat gtg gag cgg ctg cac     1277
 Arg Leu Trp Leu Ala Glu Leu Lys Arg Leu Tyr Val Glu Arg Leu His
 280                 285                 290                 295

 gag gtg acc cag aag gct gag cgc agc gag cgc aac ctc cag ctg cag     1325
 Glu Val Thr Gln Lys Ala Glu Arg Ser Glu Arg Asn Leu Gln Leu Gln
                 300                 305                 310

 ctg ttt atg gct cag cag gag cag cgg cgc ctg cgc aag gag ctg cgg     1373
 Leu Phe Met Ala Gln Gln Glu Gln Arg Arg Leu Arg Lys Glu Leu Arg
             315                 320                 325

 gct cag cag ggc ctg gct ccg gag cct cgg gcc ccc ggc acc ctc cca     1421
 Ala Gln Gln Gly Leu Ala Pro Glu Pro Arg Ala Pro Gly Thr Leu Pro
         330                 335                 340

 gag gct gac ccc agt gca cga cca gag gag gaa gcc cga tgg gag gtg     1469
 Glu Ala Asp Pro Ser Ala Arg Pro Glu Glu Glu Ala Arg Trp Glu Val
     345                 350                 355

 tgc cag aag aca gca gag att agc ctc ttg aag cag cag ctg cgt gaa     1517
 Cys Gln Lys Thr Ala Glu Ile Ser Leu Leu Lys Gln Gln Leu Arg Glu
 360                 365                 370                 375

 gcc cag gcg gaa ctg gcc cag aag ctg gcg gag atc ttc agt ctg aag     1565
 Ala Gln Ala Glu Leu Ala Gln Lys Leu Ala Glu Ile Phe Ser Leu Lys
                 380                 385                 390

 aca caa ctt cgg ggc agc cgg gca caa gcc cag gct cag gac gca gag     1613
 Thr Gln Leu Arg Gly Ser Arg Ala Gln Ala Gln Ala Gln Asp Ala Glu
             395                 400                 405

 ctg gtc cgg ctg cgc gag gct gtg cgc agc ctg cag gag cag gcc cct     1661
 Leu Val Arg Leu Arg Glu Ala Val Arg Ser Leu Gln Glu Gln Ala Pro
         410                 415                 420

 cgg gag gaa gcc cca ggc agc tgt gag act gat gac tgc aag agc agg     1709
 Arg Glu Glu Ala Pro Gly Ser Cys Glu Thr Asp Asp Cys Lys Ser Arg
     425                 430                 435

 ggc ctg cta ggg gag gca gga ggc agc gag gcc aga gac agt gct gag     1757
 Gly Leu Leu Gly Glu Ala Gly Gly Ser Glu Ala Arg Asp Ser Ala Glu
 440                 445                 450                 455

 cag ctg cgg gct gag ctg ctg cag gag cga ctt cgg ggc cag gag cag     1805
 Gln Leu Arg Ala Glu Leu Leu Gln Glu Arg Leu Arg Gly Gln Glu Gln
                 460                 465                 470

 gcg ctg cgc ttt gag cag gag cgg cgg act tgg cag gag gag aag gag     1853
 Ala Leu Arg Phe Glu Gln Glu Arg Arg Thr Trp Gln Glu Glu Lys Glu
             475                 480                 485

 cgc gtg ctg cgc tac cag cgg gag atc cag gga ggg tac atg gac atg     1901
 Arg Val Leu Arg Tyr Gln Arg Glu Ile Gln Gly Gly Tyr Met Asp Met
         490                 495                 500

 tac cgc cgc aac cag gca ctg gag cag gaa ctg cgg gca ctg cgg gag     1949
 Tyr Arg Arg Asn Gln Ala Leu Glu Gln Glu Leu Arg Ala Leu Arg Glu
     505                 510                 515

 ccc ccc aca ccc tgg agt ccc cgg ctc gag tcc tcc aag atc tga ggc     1997
 Pro Pro Thr Pro Trp Ser Pro Arg Leu Glu Ser Ser Lys Ile 
 520                 525                 530

 cagcagagcg agctgacagc agcaacactg tcagaaggtg ccctgagacg gccggctcag   2057

 ccttcccttg cactggttgg ggtggaacct gcagaggcca gcccggggct ggggaggcgc   2117

 aaggagagga gggatccagt ggggccgtgg gctgggtagg gtgccttggc aggagccagg   2177

 acaaggccct cctggcagag gagcacctag gcagggccca gccctgcttc ctggagtgga   2237

 tgtggcccag agaaggaggc tgggggatca ccagccccaa ggtcccgaag ggcaggtcag   2297

 agggagagag gctggagacc tgggctgggg ccttcctcca gggaaggagg ctggggtggg   2357

 aacactggcc tcccccagaa taaaaccatg ttttctacca gaggctcaga atacgctgag   2417

 cctgtgacca aaggatgatg gatggtcggg attgaggctg ttgacctggg cagtagctcc   2477

 tcccatggcc agtggtcagt gggagggtgt gccctgcgcc tgtctgcata cccactgggc   2537

 atgtgtgttg ggagcagagg agtcctactc cttgcctcag ccccacacgg ttccttagct   2597

 gccgtgtggg ctgaaattcc tttctttagc accagtggag ttttcagaag gaacaacacc   2657

 agggaatgcc aaaaaaacaa agggcaagtc aaccaaggca ttttgagaac atgaaatgtc   2717

 ttcttggtgg gaaggctggg ccccaggagt atccacaggc tcaggccatg cccctccccg   2777

 cacccacctc ctgtctccct ccctccctcc ataggagtgg ggggccccta gaagtgctct   2837

 gcctcattcc ctgttcgtag gaaggtgcag gagaggaggt gggcaagctt atgggtttct   2897

 tggtaaagag cctttaccac agcaaggaat gggaacattt ccccatcagc aacggggctc   2957

 tagggcatta ttaagtaggg gtgaaatatg attgatttgc attctggaaa gctctcccag   3017

 gaggaagcat tccccacccc accttgcctc tgtcctgcgc tgggctccag gacggtcagt   3077

 cctcccagat ccctgctctc agctaaggct ggtccctaaa acccacacct gcctttggtc   3137

 tctcagaggc ctggcttgcc ctctgggcct ttgctccccc gctgggtgcc cggcctggaa   3197

 cacaggttct gtctggctgt gtgagtggcg tctctccctt cctttgaggg aagctcagct   3257

 ttcttacgcg ctcatcgttg gacgggctgc catgcattgc gtgcttactg ggcgccaggt   3317

 gctgtgctgg gcccttgtga gtgtgggggc acaggctgaa ttagatgagc tcctgccgca   3377

 gggggccctg cacactgatg tcagctcacc agtctcttcc ctgacagggc agctcaggga   3437

 acttctgaga agttatctgc agagagcccc ccctcactcc ctttggctac cctggccgtg   3497

 cctggcagcc cctcaggccc cacaggtggg tcctggttgt gaagtggagt tagtgcacat   3557

 ggatgtcagg ggacgggtgt gaggcatgag ctgggggggc cccctttttc agggcagaga   3617

 atgaggcgtg tgcactgtct gctgtgggga tggtgtgttt atggccatgt aagtggcagg   3677

 tgtgtgtaaa gatgtgcttg tgggtggtgg gtgtgtctga gggggtgtgt ttgggagcct   3737

 ggcctccaaa agccagtgtc tgggttggag acagtgcagg ccccttcttg gccccaccct   3797

 ctaccccatt ccttcctgtc agccccagtc tgtcttggca ctggccaggc ttgggtggag   3857

 cctgtgtccc agacagatcc cctaggccta tctgagaccc atgcaggccc acacctgagc   3917

 tcctgtctgc ctgaggaggg aaagggggag tggccaggtc aggcaggcca gtcgtctaca   3977

 cacccccttg gtacccattc ccatttcaca aactcctcca aaccccaaac cccaaacgga   4037

 aatctctggg acaatggctc ctccagaggg cccctcagag ccaggtgctg gccagatgcc   4097

 ttgatcacag cctccatggc caggggcctg tcaagccagg ggcccacaca cctggtgcca   4157

 gggcccacct cggtatacca gctcggcaga acagttcccc acccagcgat tagggagctg   4217

 ggctggccag tacagccagt ggggagtggg tgggaggcac caaaacttgg cagctgtgcc   4277

 agaaaccaaa gccaggccca gatgtagggg gagggcacga gagctgaacc tgagcctggg   4337

 gcgtctcgga gctggatccc cgtcagctca tccaggctgg acaaaccagt tcctgggtcc   4397

 cccagccggc tgggtggctc tggggccaac cgaccacagg tgtcactgat cacaggtgtc   4457

 accgtagtgg ctaccacctc agggcagccc ctccctccag ctggcggggc ctcagcttcc   4517

 cagctgccct ggcttagcct tccctgcagc ccctccccaa caggcttggt ccgggcagcc   4577

 tgctctgcgg aaggtggcag cctcctggtg ctgggctccc tgcctctggg gcctccagtc   4637

 cttcactcag tgtcatccct tccagcagct ccctgggcct cttggtccat cccttcaggc   4697

 ttctgacaca ctagtggcct cgagtcactg atagtggtgc ctcctcctta ccttggcaag   4757

 cccttgtaag ccctctgagc cctcatcctg caggcagagc ccctcagtgc tctgagaaac   4817

 ctgccctgaa ctcaccgcct cccctgcctg ggcactccct cctccctgcg cccacagccc   4877

 ccatgccaat ctccgtcagc tctttctgtg ctgctgtaat tgttggtttg cctgtctcct   4937

 ttgagctgtg ggcattgccg gggtagggtg gtgtcttcac cacagctcca gaaggcactg   4997

 gtgggatgtg gagtcaggag caaccagaga ccccccaata ctagaatggg tttgagcttg   5057

 gggtggggtg gatggggaag acttactctg aatgttcgtt caccatccgt gggcaccagg   5117

 tctgtgccaa gcacagggac tccaggggca gctgccattc gttccagtga tgtatttggg   5177

 gccttctcag gtgaggaagc caaggtggcc aaggccctcg gtcccctgcc ctgatagggc   5237

 ttacctgtgg gtgggggagg gagaccacac atgtcagagg tagtgaaggc cgctccaaat   5297

 agtgactggg gccaggcagg cggaaaagag aacagaagag aatccagaag tgttcagaca   5357

 gaactaggga caacagaggg gcctccatgg tggcatgggt cagcagagca tggagcaggc   5417

 agaggaagcc tatctgtggg gctgggtaca tttctctgag actcacggaa tgtaagtgtt   5477

 gaggtttctg caaagagggc gcaggccctg cagtgacggt tcagatattg ataacccatc   5537

 ccccttggca ggtgggggct taggcatcca tattggattc agaaaagaaa aagaatgatg   5597

 cttcttgcaa caaaaacaaa agtgattatg tcacgagagg agaggctgga gggccatggg   5657

 agttcccagc tggctcactc atccgtccag gaggtgggtc tcatggtttc attttgcttt   5717

 gggcttactt agagttttgg caaatgcaga gttatgtaac gaacccaaca atgaagatac   5777

 agttctgtca cccccccagc attctcctgt ggccctctag tccacccccc gccccaccca   5837

 ggcccctggc aaccactgat ctgctttcac aataaccgta tggggttttt tctctttcct   5897

 tttttgtgag cggtatttaa ttcctttgct ctaatatgta atattagaac atattacaaa   5957

 gtagcaagaa aaatacgaca ttggtgtaaa aataatctac acctcatgga aagaatgaag   6017

 agccagaaat agattctatt ctgtagaaaa tcttacacaa taaaggactt caaaataagg   6077

 gtaaggaagg atgctttaac aagcggtgct gggataactg gataaaaatt tgggaaaaaa   6137

 gtcatactat gtgccacccc tgcatttatt ttattatttt atttta                  6183




      <210> 52
      <211> 5129
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (604)..(3810)

      <400> 52
 gaacaccgcg gggcaagatg gcggtagtgc gtcggctgct gccccgggtc tggcagaact     60

 cgggtgtttt gggctgagac agtggcagct gcggccccga ccccaagtgc ggggacctcc    120

 ggcgaataaa ggtcggcctg cgggtaggcc ggtagggcct gcggtccggc ctgcgggaga    180

 actgggtcgt cagtcctccg agtggtgggg ctggggactt tgagggagtt ggctctaggg    240

 cacagtccct gcctggccag gtcggaggaa caagtgctgg gatctggcgt gtgtgctcca    300

 ggggctcttt ccgcggccct ttccacctct tttcactttg gggacggtag gcctttataa    360

 acggactaat gctgggtgat ttgttcctgt ggttgttgat gccgaggaaa gactctgggc    420

 cccaggactc acctaaactg gagttcgaat actgttcgct cgctgtgtga ccttggaaaa    480

 aataacaagc ttttctgaag tgagaagctg ttctcagcca cgagtcctgt gcaagatcac    540

 taatgattac ctggcatttc tgcgacacag gcaggtcctc agggtttgtg caagtttgca    600

 aac  atg ttc acc ctg tct cag acc tcg aga gca tgg ttc atc gat aga     648
      Met Phe Thr Leu Ser Gln Thr Ser Arg Ala Trp Phe Ile Asp Arg
        1               5                  10                  15

 gcc cgt cag gca cga gaa gaa agg ctt gtg cag aag gaa cgg gag cgg      696
 Ala Arg Gln Ala Arg Glu Glu Arg Leu Val Gln Lys Glu Arg Glu Arg
                  20                  25                  30

 gca gct gtt gtg atc cag gcc cat gtc cgg agt ttt ctc tgt cgg agt      744
 Ala Ala Val Val Ile Gln Ala His Val Arg Ser Phe Leu Cys Arg Ser
              35                  40                  45

 cga ctg cag aga gat atc agg aga gag att gat gac ttt ttt aaa gca      792
 Arg Leu Gln Arg Asp Ile Arg Arg Glu Ile Asp Asp Phe Phe Lys Ala
          50                  55                  60

 gat gac cct gag tcc act aaa aga agt gca ctt tgt att ttc aag att      840
 Asp Asp Pro Glu Ser Thr Lys Arg Ser Ala Leu Cys Ile Phe Lys Ile
      65                  70                  75

 gcc agg aaa ctg ctg ttc cta ttc aga atc aaa gag gat aat gag aga      888
 Ala Arg Lys Leu Leu Phe Leu Phe Arg Ile Lys Glu Asp Asn Glu Arg
  80                  85                  90                  95

 ttt gag aag ttg tgt cgc agc atc ctg agc agc atg gat gct gag aat      936
 Phe Glu Lys Leu Cys Arg Ser Ile Leu Ser Ser Met Asp Ala Glu Asn
                 100                 105                 110

 gag cct aag gtg tgg tat gtg tcc ctg gct tgt tct aag gac ctc acc      984
 Glu Pro Lys Val Trp Tyr Val Ser Leu Ala Cys Ser Lys Asp Leu Thr
             115                 120                 125

 ctc ctt tgg att caa cag atc aag aac att ttg tgg tac tgc tgt gat     1032
 Leu Leu Trp Ile Gln Gln Ile Lys Asn Ile Leu Trp Tyr Cys Cys Asp
         130                 135                 140

 ttt ctc aag cag ctc aag cct gaa atc ctg cag gac tcc cga ctc atc     1080
 Phe Leu Lys Gln Leu Lys Pro Glu Ile Leu Gln Asp Ser Arg Leu Ile
     145                 150                 155

 acc ctg tac ctc acg atg ctt gtc acc ttc aca gac act tca acg tgg     1128
 Thr Leu Tyr Leu Thr Met Leu Val Thr Phe Thr Asp Thr Ser Thr Trp
 160                 165                 170                 175

 aaa att ctt cgg gga aaa ggt gaa agt ctt cga cca gcg atg aac cac     1176
 Lys Ile Leu Arg Gly Lys Gly Glu Ser Leu Arg Pro Ala Met Asn His
                 180                 185                 190

 att tgt gca aat ata atg gga cat ctc aac cag cat gga ttt tat tct     1224
 Ile Cys Ala Asn Ile Met Gly His Leu Asn Gln His Gly Phe Tyr Ser
             195                 200                 205

 gtg ctg cag ata ttg tta acc cgt ggc ctg gca aga ccc cgt cct tgt     1272
 Val Leu Gln Ile Leu Leu Thr Arg Gly Leu Ala Arg Pro Arg Pro Cys
         210                 215                 220

 cta tcc aaa ggc act tta aca gca gct ttt tct cta gcg tta cgc cct     1320
 Leu Ser Lys Gly Thr Leu Thr Ala Ala Phe Ser Leu Ala Leu Arg Pro
     225                 230                 235

 gtg att gct gca cag ttc tca gac aat ctg att cgg ccg ttc ctc atc     1368
 Val Ile Ala Ala Gln Phe Ser Asp Asn Leu Ile Arg Pro Phe Leu Ile
 240                 245                 250                 255

 cac atc atg tct gtg cct gct ctg gtg act cat ctc agc aca gtg acc     1416
 His Ile Met Ser Val Pro Ala Leu Val Thr His Leu Ser Thr Val Thr
                 260                 265                 270

 cct gag cgc ctc act gtt tta gaa tcc cat gac atg ctt cgt aaa ttc     1464
 Pro Glu Arg Leu Thr Val Leu Glu Ser His Asp Met Leu Arg Lys Phe
             275                 280                 285

 atc ata ttt tta aga gac caa gat cga tgc cgt gat gta tgt gaa agt     1512
 Ile Ile Phe Leu Arg Asp Gln Asp Arg Cys Arg Asp Val Cys Glu Ser
         290                 295                 300

 tta gaa gga tgc cat acg ctt tgt cta atg ggc aac ctc cta cac ttg     1560
 Leu Glu Gly Cys His Thr Leu Cys Leu Met Gly Asn Leu Leu His Leu
     305                 310                 315

 ggc tcc ctc agc ccc aga gtg tta gag gag gag aca gat ggg ttc gtg     1608
 Gly Ser Leu Ser Pro Arg Val Leu Glu Glu Glu Thr Asp Gly Phe Val
 320                 325                 330                 335

 agt ttg ctc acc cag acg ctg tgc tac tgt cgg aag tat gtg tct cag     1656
 Ser Leu Leu Thr Gln Thr Leu Cys Tyr Cys Arg Lys Tyr Val Ser Gln
                 340                 345                 350

 aag aag tcc aac ctg acc cac tgg cat cct gtc ctt ggc tgg ttc tcc     1704
 Lys Lys Ser Asn Leu Thr His Trp His Pro Val Leu Gly Trp Phe Ser
             355                 360                 365

 caa tct gtg gat tat ggc ctt aac gag tca atg cac ttg atc acc aaa     1752
 Gln Ser Val Asp Tyr Gly Leu Asn Glu Ser Met His Leu Ile Thr Lys
         370                 375                 380

 cag ctg cag ttc ttg tgg ggg gtg cct ctg atc cgg atc ttc ttc tgt     1800
 Gln Leu Gln Phe Leu Trp Gly Val Pro Leu Ile Arg Ile Phe Phe Cys
     385                 390                 395

 gac atc ctg agc aag aag cta ctg gag agc cag gag cca gcc cac gca     1848
 Asp Ile Leu Ser Lys Lys Leu Leu Glu Ser Gln Glu Pro Ala His Ala
 400                 405                 410                 415

 cag cca gca tcc cct cag aat gtg ctc cca gtg aag agt ctc cta aag     1896
 Gln Pro Ala Ser Pro Gln Asn Val Leu Pro Val Lys Ser Leu Leu Lys
                 420                 425                 430

 cgt gct ttt caa aag tcg gca tca gtc cgg aat att ctc agg cct gtc     1944
 Arg Ala Phe Gln Lys Ser Ala Ser Val Arg Asn Ile Leu Arg Pro Val
             435                 440                 445

 ggg ggt aaa cgg gtc gac tct gca gaa gtc cag aag gtt tgc aac atc     1992
 Gly Gly Lys Arg Val Asp Ser Ala Glu Val Gln Lys Val Cys Asn Ile
         450                 455                 460

 tgt gtc ctc tac cag acc tcg ctg aca act ctc aca cag att cgg ctg     2040
 Cys Val Leu Tyr Gln Thr Ser Leu Thr Thr Leu Thr Gln Ile Arg Leu
     465                 470                 475

 cag ata ctc aca ggt ctc act tac ctt gat gac ctg ctt ccc aaa ctg     2088
 Gln Ile Leu Thr Gly Leu Thr Tyr Leu Asp Asp Leu Leu Pro Lys Leu
 480                 485                 490                 495

 tgg gca ttt atc tgt gag ctc ggg ccc cac gga ggg tta aag ctc ttc     2136
 Trp Ala Phe Ile Cys Glu Leu Gly Pro His Gly Gly Leu Lys Leu Phe
                 500                 505                 510

 ttg gaa tgc ctg aac aat gac act gaa gag tcc aag caa ctc ttg gcc     2184
 Leu Glu Cys Leu Asn Asn Asp Thr Glu Glu Ser Lys Gln Leu Leu Ala
             515                 520                 525

 atg ctg atg ctg ttc tgt gac tgt tcg cgg cac ctc atc aca atc ctt     2232
 Met Leu Met Leu Phe Cys Asp Cys Ser Arg His Leu Ile Thr Ile Leu
         530                 535                 540

 gat gac att gaa gtt tat gaa gaa cag att tca ttc aaa ctg gaa gag     2280
 Asp Asp Ile Glu Val Tyr Glu Glu Gln Ile Ser Phe Lys Leu Glu Glu
     545                 550                 555

 ctg gtc act atc tcc tct ttc ctg aat tct ttt gtg ttt aag atg atc     2328
 Leu Val Thr Ile Ser Ser Phe Leu Asn Ser Phe Val Phe Lys Met Ile
 560                 565                 570                 575

 tgg gat gga att gta gag aac gcc aag ggt gag acc ttg gag ctg ttc     2376
 Trp Asp Gly Ile Val Glu Asn Ala Lys Gly Glu Thr Leu Glu Leu Phe
                 580                 585                 590

 cag tct gtc cac ggg tgg ctt atg gtg ctg tac gag cgg gac tgc cgg     2424
 Gln Ser Val His Gly Trp Leu Met Val Leu Tyr Glu Arg Asp Cys Arg
             595                 600                 605

 cgg cgc ttc acc ccc gag gac cac tgg ctg cga aag gat ctc aaa cct     2472
 Arg Arg Phe Thr Pro Glu Asp His Trp Leu Arg Lys Asp Leu Lys Pro
         610                 615                 620

 agc gtg ctc ttc caa gaa ctc gac agg gac aga aaa cgg gca cag ttg     2520
 Ser Val Leu Phe Gln Glu Leu Asp Arg Asp Arg Lys Arg Ala Gln Leu
     625                 630                 635

 atc ctg cag tac atc cca cat gtc atc cct cac aaa aac aga gtt cta     2568
 Ile Leu Gln Tyr Ile Pro His Val Ile Pro His Lys Asn Arg Val Leu
 640                 645                 650                 655

 ctg ttt cga acc atg gtt acc aag gag aag gag aaa ctg ggg ctg gtg     2616
 Leu Phe Arg Thr Met Val Thr Lys Glu Lys Glu Lys Leu Gly Leu Val
                 660                 665                 670

 gaa acc agc tct gcc tcc ccg cat gtc act cac atc acc atc cgc cgg     2664
 Glu Thr Ser Ser Ala Ser Pro His Val Thr His Ile Thr Ile Arg Arg
             675                 680                 685

 tcc agg atg ctg gag gac ggc tac gag cag ctt agg cag ctc tcc cag     2712
 Ser Arg Met Leu Glu Asp Gly Tyr Glu Gln Leu Arg Gln Leu Ser Gln
         690                 695                 700

 cac gcc atg aag ggg gtc atc cgt gtg aag ttt gtc aat gac ctc ggg     2760
 His Ala Met Lys Gly Val Ile Arg Val Lys Phe Val Asn Asp Leu Gly
     705                 710                 715

 gtg gac gaa gca ggg att gat caa gac ggt gtt ttt aag gag ttc ttg     2808
 Val Asp Glu Ala Gly Ile Asp Gln Asp Gly Val Phe Lys Glu Phe Leu
 720                 725                 730                 735

 gaa gag atc atc aag aga gtt ttt gac cca gca ctc aat ctg ttc aag     2856
 Glu Glu Ile Ile Lys Arg Val Phe Asp Pro Ala Leu Asn Leu Phe Lys
                 740                 745                 750

 aca acc agt ggg gat gag agg ctg tac ccc tca ccc aca tcc tac atc     2904
 Thr Thr Ser Gly Asp Glu Arg Leu Tyr Pro Ser Pro Thr Ser Tyr Ile
             755                 760                 765

 cat gag aat tac ctg cag ctc ttc gag ttt gtg ggg aag atg ctg ggg     2952
 His Glu Asn Tyr Leu Gln Leu Phe Glu Phe Val Gly Lys Met Leu Gly
         770                 775                 780

 aag gct gtg tat gag gga att gtg gtg gac gtg cca ttt gca tcc ttc     3000
 Lys Ala Val Tyr Glu Gly Ile Val Val Asp Val Pro Phe Ala Ser Phe
     785                 790                 795

 ttc ctg agc caa ctg ctt ggg cac cac cac agc gtc ttc tat agc tcg     3048
 Phe Leu Ser Gln Leu Leu Gly His His His Ser Val Phe Tyr Ser Ser
 800                 805                 810                 815

 gtg gat gaa ctg cct tct ctg gac tcc gag ttc tat aaa aac ctc acc     3096
 Val Asp Glu Leu Pro Ser Leu Asp Ser Glu Phe Tyr Lys Asn Leu Thr
                 820                 825                 830

 tcc atc aag cgc tat gat ggg gac atc act gac ctg ggc ctg acg ctg     3144
 Ser Ile Lys Arg Tyr Asp Gly Asp Ile Thr Asp Leu Gly Leu Thr Leu
             835                 840                 845

 tct tac gac gag gac gtc atg ggt cag ctt gtt tgc cat gaa ctg att     3192
 Ser Tyr Asp Glu Asp Val Met Gly Gln Leu Val Cys His Glu Leu Ile
         850                 855                 860

 cct gga ggg aag acc att cct gtt aca aat gaa aat aaa att agc tac     3240
 Pro Gly Gly Lys Thr Ile Pro Val Thr Asn Glu Asn Lys Ile Ser Tyr
     865                 870                 875

 atc cat ctg atg gca cat ttt cga atg cac act caa ata aaa aac caa     3288
 Ile His Leu Met Ala His Phe Arg Met His Thr Gln Ile Lys Asn Gln
 880                 885                 890                 895

 aca gct gcc ctc att agc gga ttc cgt tcc att atc aaa ccc gag tgg     3336
 Thr Ala Ala Leu Ile Ser Gly Phe Arg Ser Ile Ile Lys Pro Glu Trp
                 900                 905                 910

 atc cga atg ttc tca act cct gaa ctg cag cgt ctc atc tct ggc gac     3384
 Ile Arg Met Phe Ser Thr Pro Glu Leu Gln Arg Leu Ile Ser Gly Asp
             915                 920                 925

 aat gct gag att gat ctg gaa gat tta aag aag cac aca gtc tac tac     3432
 Asn Ala Glu Ile Asp Leu Glu Asp Leu Lys Lys His Thr Val Tyr Tyr
         930                 935                 940

 ggt ggt ttc cat gga agt cac aga gtc atc atc tgg ctc tgg gat att     3480
 Gly Gly Phe His Gly Ser His Arg Val Ile Ile Trp Leu Trp Asp Ile
     945                 950                 955

 ctg gcc tcc gac ttc aca ccg gat gag aga gct atg ttt ctg aag ttc     3528
 Leu Ala Ser Asp Phe Thr Pro Asp Glu Arg Ala Met Phe Leu Lys Phe
 960                 965                 970                 975

 gtg acc agc tgc tcc aga ccc ccg ctc ctg gga ttc gcc tac ctc aag     3576
 Val Thr Ser Cys Ser Arg Pro Pro Leu Leu Gly Phe Ala Tyr Leu Lys
                 980                 985                 990

 cct cca ttc tcc atc cgc tgc gtg gag gtg tcg gac gat cag gac acc     3624
 Pro Pro Phe Ser Ile Arg Cys Val Glu Val Ser Asp Asp Gln Asp Thr
             995                1000                1005

 ggg gac act ctg ggc agc gtc ctc cgg ggc ttc ttc acc atc cgc aag     3672
 Gly Asp Thr Leu Gly Ser Val Leu Arg Gly Phe Phe Thr Ile Arg Lys
        1010                1015                1020

 cgg gag cca ggc ggc cgc ctg ccc acc tcc tcc acc tgc ttc aac ctg     3720
 Arg Glu Pro Gly Gly Arg Leu Pro Thr Ser Ser Thr Cys Phe Asn Leu
    1025                1030                1035

 ctc aag ctg ccc aac tac agc aag aag agc gtc ctc cgc gag aag ctg     3768
 Leu Lys Leu Pro Asn Tyr Ser Lys Lys Ser Val Leu Arg Glu Lys Leu
1040                1045                1050                1055

 cgc tac gcc atc agc atg aac acg ggc ttt gaa ctc tcc tag ctcctgt     3817
 Arg Tyr Ala Ile Ser Met Asn Thr Gly Phe Glu Leu Ser 
                1060                1065

 cccagccctg cctccagggc tcctgggctg ccagggacct tcagctccca gaggcagtgt   3877

 ggtcctggga atgtgaccaa catgccaggt gacattggcc cctagaccct ctctatagcc   3937

 atgagactcc ttgtggcctc aagaaattta gacgcccacg acagcactac acagcatctc   3997

 caggtgatgc ccaaggcaca gggctgcaga aaataaacct ccagattcca ccaacacggg   4057

 tccattcttc ctggtgatgg cagaggggct tcttttagct agtttgatct tttgggagtc   4117

 tgtctttcct tagccgtctg agtgagctgt gtatgaacaa gtcccaggag ttccaagagt   4177

 ctagagtggt ttttgcagca tgggttgagt gtacaaagcc tactgtgcgt gagatcctct   4237

 ccttccgttt ctgaaatctc ttactcaggt aaggcctcgc caagacctct ttagcttgcc   4297

 cccacaaagt ttggtgccta catgccggtg ccctgtttgt ggtctgtgtt gacagccacc   4357

 caccctctcc cacctcatgc tcctgcacct gcaccaccaa ggttgatgcc ggattcgaag   4417

 ccaggaaggc ccagtccctc ctctgctctc ctcaaagacg caaaacattt tccaacaaga   4477

 gctgtcacag tggcagcaaa gcaggggcca cccgtctcca cagtccttca gagtttcagc   4537

 tgcatcctgg tgtcccaccc aggtcgagcc cccaggcttc tggaaaacag tgtgtgctct   4597

 actttgatgg aaacatggca aggaatttaa agacaggaat gtattaatat tattgaaggt   4657

 gtgttcgtaa cctctgattc tgtggacttg ccactttctc caaacgctcg gttcctttga   4717

 agatttcttc tgaacgtgtg tgcgcacgct gggcgggttc gtgcatacat gcggggaccc   4777

 cagactgtca gcacagggaa gatggatccc atcctaattt ttatcccctg aaggttggaa   4837

 ccagtgaggg tctgggaaaa agttatttat aagccccaat atcaacttca tgtggatttt   4897

 tgccaaggag gggtagtttg taatttcatt taaattcttt tcagcagctg gaaatattgc   4957

 cctatttgaa accctgaatt tccttttgta actggtgttc cctgacccct tgatggctct   5017

 tgatggcttt aaaaagttgt aggatttttt gtttttgtag ctaacttatg gattgaaatg   5077

 tgatcaaagg ctttattaaa tttgtacttc agcatatgat aaaaaaaaac cc           5129




      <210> 53
      <211> 539
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (6)..(425)

      <400> 53
 attga    atg tca cta ctc cag tgc ggt gga att cgg tgt ttt aag atg      47
          Met Ser Leu Leu Gln Cys Gly Gly Ile Arg Cys Phe Lys Met
            1               5                  10

 cct gag cca gcc aag tct gct ccc gcc ccg aag aag ggc tcc aag aag       95
 Pro Glu Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys Lys
  15                  20                  25                  30

 gca gtg acc aaa gcg cag aag aaa gat ggc aag aag cgc aag cgc agc      143
 Ala Val Thr Lys Ala Gln Lys Lys Asp Gly Lys Lys Arg Lys Arg Ser
                  35                  40                  45

 cgc aag gag agt tac tct gtg tac gtg tac aag gtg ctg aaa cag gtc      191
 Arg Lys Glu Ser Tyr Ser Val Tyr Val Tyr Lys Val Leu Lys Gln Val
              50                  55                  60

 cat ccc gac act ggc atc tct tcc aag gcc atg ggc atc atg aat tct      239
 His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Gly Ile Met Asn Ser
          65                  70                  75

 ttc gtt aac gac ata ttt gag cgc atc gcg ggc gag gct tcc cgc ctg      287
 Phe Val Asn Asp Ile Phe Glu Arg Ile Ala Gly Glu Ala Ser Arg Leu
      80                  85                  90

 gcg cat tac aac aag cgc tcg acc atc acc tcc agg gag atc cag acg      335
 Ala His Tyr Asn Lys Arg Ser Thr Ile Thr Ser Arg Glu Ile Gln Thr
  95                 100                 105                 110

 gcc gtg cgc ctg ctg ctt ccg ggg gag ctg gcc aag cac gcc gtg tcg      383
 Ala Val Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala Val Ser
                 115                 120                 125

 gag ggc acc aag gcc gtc acc aag tac acc agt tcc aag taa ctttgcc      432
 Glu Gly Thr Lys Ala Val Thr Lys Tyr Thr Ser Ser Lys 
             130                 135

 aagtaagcat ctttacacct aatcccaaag gctcttttaa gagccacgca tgttttcaat    492

 aaatgagttg taatcatttc attcaaaaaa aaaaaaaaaa aacactt                  539




      <210> 54
      <211> 366
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (112)..(312)

      <400> 54
 gcgaggatta ccctcccgga ggcgttgtct gcgactcggc ggaggctcca acttccagtg     60

 gcccggtcgg gaaagatcag agcctcctaa gaaatatcca gaagtcaagc c atg gat     117
                                                          Met Asp
                                                            1

 cca cct gca cgt aaa gaa aaa acc aaa gtt aaa gaa tct gtc agc aga      165
 Pro Pro Ala Arg Lys Glu Lys Thr Lys Val Lys Glu Ser Val Ser Arg
           5                  10                  15

 gtt gag aag gcc aaa cag aaa tca gcc cag cag gag ctg aag cag aga      213
 Val Glu Lys Ala Lys Gln Lys Ser Ala Gln Gln Glu Leu Lys Gln Arg
      20                  25                  30

 caa aga gca gag atc tat gcc ctc aac aga gtc atg aca gaa ctg gag      261
 Gln Arg Ala Glu Ile Tyr Ala Leu Asn Arg Val Met Thr Glu Leu Glu
  35                  40                  45                  50

 cag cag cag ttt gat gag ttc tgt aaa cag atg cag cct cct gga gaa      309
 Gln Gln Gln Phe Asp Glu Phe Cys Lys Gln Met Gln Pro Pro Gly Glu
                  55                  60                  65

 tga ggcc ccaggttcaa accagatggg atcctgagag ctttgagagg gtgttgccag      366
 






      <210> 55
      <211> 4418
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (228)..(3995)

      <400> 55
 aggacaacat atcaggtggg gatagcagtg caacagaaag ctgggatgag gagctttctc     60

 cttccactgt gttgtataca gcaacacagc acacacctac aagcatcacc ttaactgtta    120

 gaagaaccaa acccaagaag cggaaaaaga gtccagaaaa gggtcgtgca gcaccaaaga    180

 cgaagaaaat caaggcattt cgagagggat cccggaagtc cttgcgg  atg aag aat     236
                                                      Met Lys Asn
                                                        1

 tct ccc tct gaa gca cag aat tta gat gag aat aca act gag ggc tgg      284
 Ser Pro Ser Glu Ala Gln Asn Leu Asp Glu Asn Thr Thr Glu Gly Trp
       5                  10                  15

 gaa aat cgg ata aga cta tgg act gac cag tat gaa gaa gct ttc act      332
 Glu Asn Arg Ile Arg Leu Trp Thr Asp Gln Tyr Glu Glu Ala Phe Thr
  20                  25                  30                  35

 aat cag tac agt gca gat gta cag aac gcg ctt gaa caa cac cta cat      380
 Asn Gln Tyr Ser Ala Asp Val Gln Asn Ala Leu Glu Gln His Leu His
                  40                  45                  50

 tct agc aag gaa ttt gtg ggc aaa cct act att tta gac act att aat      428
 Ser Ser Lys Glu Phe Val Gly Lys Pro Thr Ile Leu Asp Thr Ile Asn
              55                  60                  65

 aag act gaa ttg gcc tgt aat aac aca gtt att ggt tcc caa atg cag      476
 Lys Thr Glu Leu Ala Cys Asn Asn Thr Val Ile Gly Ser Gln Met Gln
          70                  75                  80

 tta cag ctg gga aga gtc act cgt gtt caa aag cac cgg aag atc ctg      524
 Leu Gln Leu Gly Arg Val Thr Arg Val Gln Lys His Arg Lys Ile Leu
      85                  90                  95

 agg gct gca aga gat ttg gct ttg gac act ctt ata ata gag tat cgt      572
 Arg Ala Ala Arg Asp Leu Ala Leu Asp Thr Leu Ile Ile Glu Tyr Arg
 100                 105                 110                 115

 ggg aaa gtc atg tta cga cag caa ttt gag gtc aat ggg cat ttc ttc      620
 Gly Lys Val Met Leu Arg Gln Gln Phe Glu Val Asn Gly His Phe Phe
                 120                 125                 130

 aaa aaa cca tac ccc ttt gtg ctc ttc tac tca aaa ttc aat ggt gta      668
 Lys Lys Pro Tyr Pro Phe Val Leu Phe Tyr Ser Lys Phe Asn Gly Val
             135                 140                 145

 gag atg tgt gtg gat gcc cgt act ttc ggt aat gat gct cgg ttc atc      716
 Glu Met Cys Val Asp Ala Arg Thr Phe Gly Asn Asp Ala Arg Phe Ile
         150                 155                 160

 aga aga tca tgt aca cca aat gca gag gtg cga cac atg att gca gat      764
 Arg Arg Ser Cys Thr Pro Asn Ala Glu Val Arg His Met Ile Ala Asp
     165                 170                 175

 ggg atg att cac ctg tgc atc tat gct gtg tct gcc atc acc aag gat      812
 Gly Met Ile His Leu Cys Ile Tyr Ala Val Ser Ala Ile Thr Lys Asp
 180                 185                 190                 195

 gct gag gtc acc ata gca ttt gat tat gag tat agt aac tgt aat tat      860
 Ala Glu Val Thr Ile Ala Phe Asp Tyr Glu Tyr Ser Asn Cys Asn Tyr
                 200                 205                 210

 aaa gtg gac tgt gcc tgt cac aag gga aac cgg aat tgt cct ata caa      908
 Lys Val Asp Cys Ala Cys His Lys Gly Asn Arg Asn Cys Pro Ile Gln
             215                 220                 225

 aaa agg aat cct aat gct aca gaa ctg cca ctc cta cca cct cct cca      956
 Lys Arg Asn Pro Asn Ala Thr Glu Leu Pro Leu Leu Pro Pro Pro Pro
         230                 235                 240

 agc cta ccc acc att gga gca gag act aga cgt aga aaa gca cga cgg     1004
 Ser Leu Pro Thr Ile Gly Ala Glu Thr Arg Arg Arg Lys Ala Arg Arg
     245                 250                 255

 aaa gag cta gag atg gag cag cag aat gag gct tca gag gag aat aat     1052
 Lys Glu Leu Glu Met Glu Gln Gln Asn Glu Ala Ser Glu Glu Asn Asn
 260                 265                 270                 275

 gac cag caa tca caa gaa gtt cca gaa aaa gta act gta tcc agt gat     1100
 Asp Gln Gln Ser Gln Glu Val Pro Glu Lys Val Thr Val Ser Ser Asp
                 280                 285                 290

 cat gag gaa gta gac aat cca gaa gaa aaa cca gaa gaa gag aaa gaa     1148
 His Glu Glu Val Asp Asn Pro Glu Glu Lys Pro Glu Glu Glu Lys Glu
             295                 300                 305

 gag gtt ata gat gac cag gag aac cta gct cat agc agg agg acc agg     1196
 Glu Val Ile Asp Asp Gln Glu Asn Leu Ala His Ser Arg Arg Thr Arg
         310                 315                 320

 gaa gat aga aag gta gaa gcc atc atg cat gct ttt gaa aac tta gag     1244
 Glu Asp Arg Lys Val Glu Ala Ile Met His Ala Phe Glu Asn Leu Glu
     325                 330                 335

 aaa aga aag aag cgg cgg gat cag ccc ttg gaa cag agc aac tct gat     1292
 Lys Arg Lys Lys Arg Arg Asp Gln Pro Leu Glu Gln Ser Asn Ser Asp
 340                 345                 350                 355

 gta gag att act aca acc acc tca gag act cct gtt ggt gaa gag aca     1340
 Val Glu Ile Thr Thr Thr Thr Ser Glu Thr Pro Val Gly Glu Glu Thr
                 360                 365                 370

 aaa act gaa gcc cct gaa tct gaa gtt agc aac tct gtt tca aat gtt     1388
 Lys Thr Glu Ala Pro Glu Ser Glu Val Ser Asn Ser Val Ser Asn Val
             375                 380                 385

 acc atc cca agc acc cca cag agt gtt ggt gtg aat acc cgg agg tct     1436
 Thr Ile Pro Ser Thr Pro Gln Ser Val Gly Val Asn Thr Arg Arg Ser
         390                 395                 400

 tcc caa gca ggg gat att gct gca gaa aaa cta gtc ccc aag cca cct     1484
 Ser Gln Ala Gly Asp Ile Ala Ala Glu Lys Leu Val Pro Lys Pro Pro
     405                 410                 415

 cca gca aag cct tct agg ccc cgg ccg aag agt cga att tct cgg tac     1532
 Pro Ala Lys Pro Ser Arg Pro Arg Pro Lys Ser Arg Ile Ser Arg Tyr
 420                 425                 430                 435

 agg acc agt tca gcc caa aga cta aag cgt cag aag cag gcc aat gca     1580
 Arg Thr Ser Ser Ala Gln Arg Leu Lys Arg Gln Lys Gln Ala Asn Ala
                 440                 445                 450

 cag cag gca gaa ttg tca caa gct gcc ttg gaa gag gga gga agt aac     1628
 Gln Gln Ala Glu Leu Ser Gln Ala Ala Leu Glu Glu Gly Gly Ser Asn
             455                 460                 465

 agt tta gta act cct act gaa gct gga agt cta gac agt tca gga gaa     1676
 Ser Leu Val Thr Pro Thr Glu Ala Gly Ser Leu Asp Ser Ser Gly Glu
         470                 475                 480

 aac agg cca tta aca ggg tct gac cca act gtg gtg tca att act gga     1724
 Asn Arg Pro Leu Thr Gly Ser Asp Pro Thr Val Val Ser Ile Thr Gly
     485                 490                 495

 tcc cat gtc aac cgt gct gca tct aaa tac ccc aaa acc aaa aag tat     1772
 Ser His Val Asn Arg Ala Ala Ser Lys Tyr Pro Lys Thr Lys Lys Tyr
 500                 505                 510                 515

 cta gtt aca gaa tgg ttg aat gac aaa gca gag aag caa gag tgc cct     1820
 Leu Val Thr Glu Trp Leu Asn Asp Lys Ala Glu Lys Gln Glu Cys Pro
                 520                 525                 530

 gtt gag tgc cct tta cgt atc aca acg gat cca act gta ctg gca acg     1868
 Val Glu Cys Pro Leu Arg Ile Thr Thr Asp Pro Thr Val Leu Ala Thr
             535                 540                 545

 acc cta aac atg tta cca ggt ctt atc cat tcc ccg tta att tgc acc     1916
 Thr Leu Asn Met Leu Pro Gly Leu Ile His Ser Pro Leu Ile Cys Thr
         550                 555                 560

 acc ccc aaa cac tac att cgc ttt ggc tca ccc ttt atc cct gag aga     1964
 Thr Pro Lys His Tyr Ile Arg Phe Gly Ser Pro Phe Ile Pro Glu Arg
     565                 570                 575

 cgt cga agg ccc ctt ctg cct gat ggc aca ttc agc ccc tgt aag aag     2012
 Arg Arg Arg Pro Leu Leu Pro Asp Gly Thr Phe Ser Pro Cys Lys Lys
 580                 585                 590                 595

 cgc tgg ata aaa caa gcc tta gaa gaa ggg atg act caa aca tca tct     2060
 Arg Trp Ile Lys Gln Ala Leu Glu Glu Gly Met Thr Gln Thr Ser Ser
                 600                 605                 610

 gta ccc caa gag act aga act cag cac cta tac caa agc aat gag aat     2108
 Val Pro Gln Glu Thr Arg Thr Gln His Leu Tyr Gln Ser Asn Glu Asn
             615                 620                 625

 agt agc tct tct agt atc tgc aaa gac aat gca gac ttg ttg agc cca     2156
 Ser Ser Ser Ser Ser Ile Cys Lys Asp Asn Ala Asp Leu Leu Ser Pro
         630                 635                 640

 tta aag aaa tgg aag tct cgc tat ctg atg gag cag aat gtc acc aag     2204
 Leu Lys Lys Trp Lys Ser Arg Tyr Leu Met Glu Gln Asn Val Thr Lys
     645                 650                 655

 tta ctt cgg cct ctg tct cca gtc aca cca ccc cct ccc aat tca ggc     2252
 Leu Leu Arg Pro Leu Ser Pro Val Thr Pro Pro Pro Pro Asn Ser Gly
 660                 665                 670                 675

 tca aag agt ccc cag ctg gcc aca cct ggc tca tct cac cca gga gaa     2300
 Ser Lys Ser Pro Gln Leu Ala Thr Pro Gly Ser Ser His Pro Gly Glu
                 680                 685                 690

 gag gag tgt cga aat gga tac agc ctc atg ttt tca cca gtc aca tct     2348
 Glu Glu Cys Arg Asn Gly Tyr Ser Leu Met Phe Ser Pro Val Thr Ser
             695                 700                 705

 ctt act act gct agt cgc tgc aac act cct cta cag ttt gag ctt tgt     2396
 Leu Thr Thr Ala Ser Arg Cys Asn Thr Pro Leu Gln Phe Glu Leu Cys
         710                 715                 720

 cac cga aaa gac ctg gat ttg gca aaa gta gga tac ctt gac tcc aac     2444
 His Arg Lys Asp Leu Asp Leu Ala Lys Val Gly Tyr Leu Asp Ser Asn
     725                 730                 735

 act aac agc tgt gct gat aga cct tcc cta ctc aac tca ggt cat tct     2492
 Thr Asn Ser Cys Ala Asp Arg Pro Ser Leu Leu Asn Ser Gly His Ser
 740                 745                 750                 755

 gac ctg gct cct cat ccc tcc ctc gga ccc act tct gag act ggt ttc     2540
 Asp Leu Ala Pro His Pro Ser Leu Gly Pro Thr Ser Glu Thr Gly Phe
                 760                 765                 770

 cca agc aga agt gga gat gga cat cag acc ctc gtg aga aac tca gac     2588
 Pro Ser Arg Ser Gly Asp Gly His Gln Thr Leu Val Arg Asn Ser Asp
             775                 780                 785

 cag gca ttt cgg aca gag ttc aac ttg atg tat gcc tac tcc cct ttg     2636
 Gln Ala Phe Arg Thr Glu Phe Asn Leu Met Tyr Ala Tyr Ser Pro Leu
         790                 795                 800

 aat gct atg cct cga gca gat gga ctg tat cga gga tct cct cta gtg     2684
 Asn Ala Met Pro Arg Ala Asp Gly Leu Tyr Arg Gly Ser Pro Leu Val
     805                 810                 815

 ggg gat agg aag cct tta cat ttg gat ggg gga tat tgt tcc cct gca     2732
 Gly Asp Arg Lys Pro Leu His Leu Asp Gly Gly Tyr Cys Ser Pro Ala
 820                 825                 830                 835

 gaa gga ttt tcc agc aga tat gaa cat ggc tta atg aaa gac ctc tct     2780
 Glu Gly Phe Ser Ser Arg Tyr Glu His Gly Leu Met Lys Asp Leu Ser
                 840                 845                 850

 cgt gga tcc ttg tca cct ggt ggt gaa agg gcc tgt gaa gga gtc cca     2828
 Arg Gly Ser Leu Ser Pro Gly Gly Glu Arg Ala Cys Glu Gly Val Pro
             855                 860                 865

 tct gcc ccc cag aac cca cca cag agg aaa aaa gta tcc ctg ctg gag     2876
 Ser Ala Pro Gln Asn Pro Pro Gln Arg Lys Lys Val Ser Leu Leu Glu
         870                 875                 880

 tac cga aaa cgg aaa caa gaa gct aag gaa aat tct gct ggt ggg gga     2924
 Tyr Arg Lys Arg Lys Gln Glu Ala Lys Glu Asn Ser Ala Gly Gly Gly
     885                 890                 895

 ggt gac tct gca cag agc aaa agc aag tct gca gga gct ggg caa ggc     2972
 Gly Asp Ser Ala Gln Ser Lys Ser Lys Ser Ala Gly Ala Gly Gln Gly
 900                 905                 910                 915

 agc agt aac tcc gtt tcc gac act ggt gcc cat ggt gtg cag gga tcc     3020
 Ser Ser Asn Ser Val Ser Asp Thr Gly Ala His Gly Val Gln Gly Ser
                 920                 925                 930

 tca gcc cga act cca tct tcc cct cac aaa aaa ttc tcc cca tct cat     3068
 Ser Ala Arg Thr Pro Ser Ser Pro His Lys Lys Phe Ser Pro Ser His
             935                 940                 945

 tcc tct atg tcc cat ttg gag gcg gta agc cca tca gat tcc aga ggc     3116
 Ser Ser Met Ser His Leu Glu Ala Val Ser Pro Ser Asp Ser Arg Gly
         950                 955                 960

 act tct tca tct cac tgc aga cct caa gag aat atc agc agt agg tgg     3164
 Thr Ser Ser Ser His Cys Arg Pro Gln Glu Asn Ile Ser Ser Arg Trp
     965                 970                 975

 atg gtt ccc aca tca gta gaa cga ctc cga gaa gga ggg agc atc ccc     3212
 Met Val Pro Thr Ser Val Glu Arg Leu Arg Glu Gly Gly Ser Ile Pro
 980                 985                 990                 995

 aag gtc ctc cga agc agc gtg agg gtg gcc caa aag gga gag ccc tct     3260
 Lys Val Leu Arg Ser Ser Val Arg Val Ala Gln Lys Gly Glu Pro Ser
                1000                1005                1010

 ccc aca tgg gag agt aac atc aca gag aaa gac tca gac cct gca gat     3308
 Pro Thr Trp Glu Ser Asn Ile Thr Glu Lys Asp Ser Asp Pro Ala Asp
            1015                1020                1025

 gga gaa ggc cca gag aca tta agc tca gca ctc tct aaa gga gca aca     3356
 Gly Glu Gly Pro Glu Thr Leu Ser Ser Ala Leu Ser Lys Gly Ala Thr
        1030                1035                1040

 gtt tac agc cct tcc aga tac agc tac cag ctc ctg cag tgt gat agt     3404
 Val Tyr Ser Pro Ser Arg Tyr Ser Tyr Gln Leu Leu Gln Cys Asp Ser
    1045                1050                1055

 cct cgg aca gaa tca caa agc ctc ctt cag cag agt tcc tcc ccc ttc     3452
 Pro Arg Thr Glu Ser Gln Ser Leu Leu Gln Gln Ser Ser Ser Pro Phe
1060                1065                1070                1075

 aga gga cat cct aca cag tct cca gga tac agt tat cga act act gca     3500
 Arg Gly His Pro Thr Gln Ser Pro Gly Tyr Ser Tyr Arg Thr Thr Ala
                1080                1085                1090

 ctg aga cct gga aac ccc ccc tct cac ggt tct tca gaa tca tcc ctc     3548
 Leu Arg Pro Gly Asn Pro Pro Ser His Gly Ser Ser Glu Ser Ser Leu
            1095                1100                1105

 tct tcc acg tcc tat tcc agc ccc gcc cac cct gtg tcc aca gac tcg     3596
 Ser Ser Thr Ser Tyr Ser Ser Pro Ala His Pro Val Ser Thr Asp Ser
        1110                1115                1120

 ttg gcc cca ttt acg ggg aca cca ggg tat ttt agc agc cag cca cat     3644
 Leu Ala Pro Phe Thr Gly Thr Pro Gly Tyr Phe Ser Ser Gln Pro His
    1125                1130                1135

 tct gga aac agc act ggc agc aat ctt cca agg agg agc tgc cct tct     3692
 Ser Gly Asn Ser Thr Gly Ser Asn Leu Pro Arg Arg Ser Cys Pro Ser
1140                1145                1150                1155

 agt gct gct agc cct acc ctg cag gga ccc tca gac tcg cca acc tca     3740
 Ser Ala Ala Ser Pro Thr Leu Gln Gly Pro Ser Asp Ser Pro Thr Ser
                1160                1165                1170

 gat tca gtt tct cag tcc agc aca gga act ctg agt tcc acc tcc ttt     3788
 Asp Ser Val Ser Gln Ser Ser Thr Gly Thr Leu Ser Ser Thr Ser Phe
            1175                1180                1185

 cct cag aac tct agg tcg tca ttg cca tca gac tta cgg act atc agt     3836
 Pro Gln Asn Ser Arg Ser Ser Leu Pro Ser Asp Leu Arg Thr Ile Ser
        1190                1195                1200

 ctg ccc agt gct ggg cag tca gct gtc tac cag gcc tcc agg gta tct     3884
 Leu Pro Ser Ala Gly Gln Ser Ala Val Tyr Gln Ala Ser Arg Val Ser
    1205                1210                1215

 gcg gtt tcc aat tca cag cac tac cca cac cgt ggg agt ggg ggt gtg     3932
 Ala Val Ser Asn Ser Gln His Tyr Pro His Arg Gly Ser Gly Gly Val
1220                1225                1230                1235

 cac cag tac cga ctc cag cca ctg caa ggg tca gga gtc aag act cag     3980
 His Gln Tyr Arg Leu Gln Pro Leu Gln Gly Ser Gly Val Lys Thr Gln
                1240                1245                1250

 acg gga ctt tcc tag ggcttctgga tttgggcaaa cagaactgaa tgagcccata     4035
 Thr Gly Leu Ser 
            1255

 gctgcttcct tccagctgcc tctggaacct aggccgagca tattgctgag gaacgggggg   4095

 tacaaggtgc cagaggattg ggtctggtgg acaagaaaca agacttgtgg tcacaattgg   4155

 cctctggcct tggagaaagc tgtaaatctt gtctgaagca gagactataa agaagtttct   4215

 ccctgctgtc aagggtacat tgttgacaag caaatggtgt ttcggttagt aacggttcta   4275

 agtgcaatga gttgtgttga agcctccgtc tcccatcctt gcctgtagcc cgtagtcact   4335

 tgtgcagtga ggacatcttt ttaaatttaa aaaaaaaaaa aaaaaaagtt ttcaaaggaa   4395

 aaaaaaaaaa aaaaaaaaaa tat                                           4418




      <210> 56
      <211> 522
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(522)

      <400> 56
  atg aag cag gag gtt aag aaa gtg gtg aat ccc ctg ctt gag aaa agg      48
  Met Lys Gln Glu Val Lys Lys Val Val Asn Pro Leu Leu Glu Lys Arg
    1               5                  10                  15

 cct aag aat ttt ggc att gga cag gac atc cag ccc aaa aga gac ctc       96
 Pro Lys Asn Phe Gly Ile Gly Gln Asp Ile Gln Pro Lys Arg Asp Leu
              20                  25                  30

 act tgc ttc aag aaa tgg tcc cac tat atc agg ttg cag tgg cag aga      144
 Thr Cys Phe Lys Lys Trp Ser His Tyr Ile Arg Leu Gln Trp Gln Arg
          35                  40                  45

 gtc atc ctc tgt aag tgg ctg aaa gtg cat cct gaa att aac cag ttc      192
 Val Ile Leu Cys Lys Trp Leu Lys Val His Pro Glu Ile Asn Gln Phe
      50                  55                  60

 acc cag gcc ctg cac cac caa aca gct act cag ttg ctt cag ctg gcc      240
 Thr Gln Ala Leu His His Gln Thr Ala Thr Gln Leu Leu Gln Leu Ala
  65                  70                  75                  80

 cac aac tac aga cca aac aag aga aag aca aag caa gag aag aag cag      288
 His Asn Tyr Arg Pro Asn Lys Arg Lys Thr Lys Gln Glu Lys Lys Gln
                  85                  90                  95

 agg ctg ttg gtc cgg gct gag aag aaa gct tgc agc aaa ggg gac atc      336
 Arg Leu Leu Val Arg Ala Glu Lys Lys Ala Cys Ser Lys Gly Asp Ile
             100                 105                 110

 tcc act agg aga cca ctt gtc ctt caa gca gga gtt aac acc gtc acc      384
 Ser Thr Arg Arg Pro Leu Val Leu Gln Ala Gly Val Asn Thr Val Thr
         115                 120                 125

 acc ttg gtg gag aac aag aag act cag ctg gtg gtg atg gca cac gat      432
 Thr Leu Val Glu Asn Lys Lys Thr Gln Leu Val Val Met Ala His Asp
     130                 135                 140

 gtg gat acc atc cag ctg gtg aac tcg gaa gac aaa gga gct ttg gct      480
 Val Asp Thr Ile Gln Leu Val Asn Ser Glu Asp Lys Gly Ala Leu Ala
 145                 150                 155                 160

 aag ctg gcg gaa gct atg agg acc aac tac aac aac aga taa              522
 Lys Leu Ala Glu Ala Met Arg Thr Asn Tyr Asn Asn Arg 
                 165                 170





      <210> 57
      <211> 847
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (126)..(800)

      <400> 57
 tgcggtctgc caggagctgc ggccccgtcc ggcccgggct ggcatgggtt ggaattggag     60

 cctatccccc aacccgaagg ctaacagcat catgtggtta ctaactgttc ctcattcacc    120

 ggttg    atg cct ccc aga aaa aaa cgc cgc cag cct tcc cag aaa gcc     167
          Met Pro Pro Arg Lys Lys Arg Arg Gln Pro Ser Gln Lys Ala
            1               5                  10

 ccg ctg ctg ttc cac caa caa cca ctg gag ggc ccc aaa cac agc tgt      215
 Pro Leu Leu Phe His Gln Gln Pro Leu Glu Gly Pro Lys His Ser Cys
  15                  20                  25                  30

 gca tct aca cag ctt ccc atc act cac act cga cag gta tca cct gat      263
 Ala Ser Thr Gln Leu Pro Ile Thr His Thr Arg Gln Val Ser Pro Asp
                  35                  40                  45

 ttt gat aca gca gca gga agc ttg ttc cca gcc tac cag aaa cac caa      311
 Phe Asp Thr Ala Ala Gly Ser Leu Phe Pro Ala Tyr Gln Lys His Gln
              50                  55                  60

 aac cgg gcg aga cac tca agt cga aaa cct acc acc tcc aag ttt cca      359
 Asn Arg Ala Arg His Ser Ser Arg Lys Pro Thr Thr Ser Lys Phe Pro
          65                  70                  75

 cat cta act ttt gag agt ccg caa tct tcc agt tca gag aca ttg ggg      407
 His Leu Thr Phe Glu Ser Pro Gln Ser Ser Ser Ser Glu Thr Leu Gly
      80                  85                  90

 atc ccc tta atc cga gag tgc ccc agt gaa tca gaa aag gat gtt tcc      455
 Ile Pro Leu Ile Arg Glu Cys Pro Ser Glu Ser Glu Lys Asp Val Ser
  95                 100                 105                 110

 aga aga ccc tta gtt cca gtg ctc agt ccc caa agc tgt ggg aac atg      503
 Arg Arg Pro Leu Val Pro Val Leu Ser Pro Gln Ser Cys Gly Asn Met
                 115                 120                 125

 tca gtg cag gca ctt cag agc tta cct tat gtg ttc att cca cct gat      551
 Ser Val Gln Ala Leu Gln Ser Leu Pro Tyr Val Phe Ile Pro Pro Asp
             130                 135                 140

 atc cag acc cca gag tca tca tct gtg aag gaa gaa ctc att ccc caa      599
 Ile Gln Thr Pro Glu Ser Ser Ser Val Lys Glu Glu Leu Ile Pro Gln
         145                 150                 155

 gat cag aag gaa aac agc ctt cta agc tgc act ctt cac act ggc act      647
 Asp Gln Lys Glu Asn Ser Leu Leu Ser Cys Thr Leu His Thr Gly Thr
     160                 165                 170

 cct aat agc cca gag cct gga cct gtt ctg gtt aaa gac acc ccc gag      695
 Pro Asn Ser Pro Glu Pro Gly Pro Val Leu Val Lys Asp Thr Pro Glu
 175                 180                 185                 190

 gac aag tat gga ata aag gtc aca tgg agg aga cga cag cac ctg ctt      743
 Asp Lys Tyr Gly Ile Lys Val Thr Trp Arg Arg Arg Gln His Leu Leu
                 195                 200                 205

 gct tac ctc agg gag aga ggg aag ctg agc aga agc caa ttc ctt gtg      791
 Ala Tyr Leu Arg Glu Arg Gly Lys Leu Ser Arg Ser Gln Phe Leu Val
             210                 215                 220

 aaa agc tga ctgccat cagtaatctc aatagaaaag agatatgttt tctggagtca      847
 Lys Ser 






      <210> 58
      <211> 1826
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (866)..(1546)

      <400> 58
 atggggaagc agccattcca gagaactgca acagcagatt gcaaaccagg acttcaggac     60

 tcagaggggg acaaggaaag gagagcctat agtggcccca aagtccaggg gcttgctaag    120

 gaatcccctg atggcctagg attccacgca gagcacatct ggtgtgagag agctcgctgc    180

 aagggtgaag gctccgccct atcagataga caaccaggcc accaagaggc ccagccctcc    240

 aaaccctgga tttgcaacat cctcaaagaa cagcaacggg ccttgagcag aattgagaag    300

 gaaatacccc cacctgccct cagccgttaa gtgggctttg ctattcacaa gggcctctgg    360

 gtgtcctggc agagagggga gatggcacag gcaccaggtg ctagggtgcc agggcctccc    420

 gagaaggaac aggtgcaaag caggcaatta gcccagaagg tatccgtggg gcaggcagcc    480

 tagatctgat gggggaagcc accaggatta catcatctgc tgtaacaact gctctgaaaa    540

 gaagatattt ttcaacctga acttgcagta gctagtggag aggcaggtaa ggaaaaagga    600

 aatgaaacag agacagaggg aagcctgagc caaaatagac cttcccgaga gaggaggaag    660

 cccggagaga gacgcacggt cccctccccg cccctaggcc gccgccccct ctctgccctc    720

 ggcggcgagc agggcgccgc gacccggggc cggaaaggtg ccaggggctc cgggcggccg    780

 ggcgggcgca caccatcccc gcgggcggcg cggagccggc gacagcgcgc gagagggacc    840

 gggcggtggc ggcggcggga ccggg  atg gaa ggg agc gcg gtg act gtc ctt     892
                              Met Glu Gly Ser Ala Val Thr Val Leu
                                1               5

 gag cgc gga ggg gcg agc tcg ccg gcg gag cgc cgg agc aag cgg agg      940
 Glu Arg Gly Gly Ala Ser Ser Pro Ala Glu Arg Arg Ser Lys Arg Arg
  10                  15                  20                  25

 cag gag cgg cgg cga cgg cgg cgg cgg cgg cgg cgc ccg agc acc cga      988
 Gln Glu Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Pro Ser Thr Arg
                  30                  35                  40

 ggg ggt ccg agc ccc ggc agc cgg cca gcc ccg cgc cac aaa ggg agc     1036
 Gly Gly Pro Ser Pro Gly Ser Arg Pro Ala Pro Arg His Lys Gly Ser
              45                  50                  55

 gcc ccc gcc gcc cgg cac ccc gcc tcc ctc ccc aat gtc ctc ggc cat     1084
 Ala Pro Ala Ala Arg His Pro Ala Ser Leu Pro Asn Val Leu Gly His
          60                  65                  70

 cga aag gaa gag cct gga ccc ttc aga gaa cca gtg gat gag gtg ctg     1132
 Arg Lys Glu Glu Pro Gly Pro Phe Arg Glu Pro Val Asp Glu Val Leu
      75                  80                  85

 cag atc ccc cca tcc ctg ctg aca tgc ggc ggc tgc cag cag aac atc     1180
 Gln Ile Pro Pro Ser Leu Leu Thr Cys Gly Gly Cys Gln Gln Asn Ile
  90                  95                 100                 105

 ggg gac cgc tac ttc ctg aag gcc atc gac cag tac tgg cac gag gac     1228
 Gly Asp Arg Tyr Phe Leu Lys Ala Ile Asp Gln Tyr Trp His Glu Asp
                 110                 115                 120

 tgc ctg agc tgc gac ctc tgt ggc tgc cgg ctg ggt gag gtg ggg cgg     1276
 Cys Leu Ser Cys Asp Leu Cys Gly Cys Arg Leu Gly Glu Val Gly Arg
             125                 130                 135

 cgc ctc tac tac aaa ctg ggc cgg aag ctc tgc cgg aga gac tat ctc     1324
 Arg Leu Tyr Tyr Lys Leu Gly Arg Lys Leu Cys Arg Arg Asp Tyr Leu
         140                 145                 150

 agg ctt ttt ggg caa gac ggt ctc tgc gca tcc tgt gac aag cgg att     1372
 Arg Leu Phe Gly Gln Asp Gly Leu Cys Ala Ser Cys Asp Lys Arg Ile
     155                 160                 165

 cgt gcc tat gag atg aca atg cgg gtg aaa gac aaa gtg tat cac ctg     1420
 Arg Ala Tyr Glu Met Thr Met Arg Val Lys Asp Lys Val Tyr His Leu
 170                 175                 180                 185

 gaa tgt ttc aag tgc gcc gcc tgt cag aag cat ttc tgt gta ggt gac     1468
 Glu Cys Phe Lys Cys Ala Ala Cys Gln Lys His Phe Cys Val Gly Asp
                 190                 195                 200

 aga tac ctc ctc atc aac tct gac ata gtg tgc gaa cag gac atc tac     1516
 Arg Tyr Leu Leu Ile Asn Ser Asp Ile Val Cys Glu Gln Asp Ile Tyr
             205                 210                 215

 gag tgg act aag atc aat ggg atg ata tag g cccgagtccc cgggcatctt     1567
 Glu Trp Thr Lys Ile Asn Gly Met Ile 
         220                 225

 tggggaggtg ttcactgaag acgccgtctc catggcatct tcgtcttcac tcttaggcac   1627

 tttgggggtt tgagggtggg gtaagggatt tcttagggga tggtagacct ttattgggta   1687

 tcaagacata gcatccaagt ggcataattc aggggctgac acttcaaggt gacagaagga   1747

 ccagcccttg agggagaact tatggccaca gcccatccat agtaactgac atgattagca   1807

 aaaaaaaaaa aaaaaaatg                                                1826




      <210> 59
      <211> 1828
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (224)..(1774)

      <400> 59
 ggatcaggat atgagagagg ttaatgactt ctaagacagt cccatgtgac ttcagcatat     60

 catgtggtag atgacaatga ggctgcacat ttctttttat gatcagaaac attattttcc    120

 caatattttg cactgctgat cagaacacat gtaaaatatt gacttcattt taacaagggt    180

 gaccagacta ataaagggat tcataaacca ggtcagatga gga  atg atc aaa ata     235
                                                  Met Ile Lys Ile
                                                    1

 aat ttt acc tta aaa aga gat gat gtg aca agt aga gtt tta gtg gaa      283
 Asn Phe Thr Leu Lys Arg Asp Asp Val Thr Ser Arg Val Leu Val Glu
   5                  10                  15                  20

 cat cgc tgt gga agc gaa aat gtt gct gcc act aca cag aaa acc ctg      331
 His Arg Cys Gly Ser Glu Asn Val Ala Ala Thr Thr Gln Lys Thr Leu
                  25                  30                  35

 cga tat gga gtc ctg act gta ttt agt gaa gaa gat ctg cat act atg      379
 Arg Tyr Gly Val Leu Thr Val Phe Ser Glu Glu Asp Leu His Thr Met
              40                  45                  50

 tct tca gca gtg gtg cag tta tat gca gca gat cgg aac tgt atg tgg      427
 Ser Ser Ala Val Val Gln Leu Tyr Ala Ala Asp Arg Asn Cys Met Trp
          55                  60                  65

 tca aag aag tgc agt ggt gtt gct tgt ctt gtt aag gac aat cca cag      475
 Ser Lys Lys Cys Ser Gly Val Ala Cys Leu Val Lys Asp Asn Pro Gln
      70                  75                  80

 aga tct tat ttt tta aga ata ttt gac att aag gat ggg aaa cta ttg      523
 Arg Ser Tyr Phe Leu Arg Ile Phe Asp Ile Lys Asp Gly Lys Leu Leu
  85                  90                  95                 100

 tgg gaa caa gag cta tac aat aac ttt gta tat aat agt cct aga gga      571
 Trp Glu Gln Glu Leu Tyr Asn Asn Phe Val Tyr Asn Ser Pro Arg Gly
                 105                 110                 115

 tat ttt cat acc ttt gct gga gat act tgt caa gtt gct ctt aat ttt      619
 Tyr Phe His Thr Phe Ala Gly Asp Thr Cys Gln Val Ala Leu Asn Phe
             120                 125                 130

 gcc aat gaa gaa gaa gca aaa aaa ttt cga aaa gca gtt aca gac ctt      667
 Ala Asn Glu Glu Glu Ala Lys Lys Phe Arg Lys Ala Val Thr Asp Leu
         135                 140                 145

 ttg ggc cgt cga caa agg aaa tct gag aaa aga cga gat ccc cca aat      715
 Leu Gly Arg Arg Gln Arg Lys Ser Glu Lys Arg Arg Asp Pro Pro Asn
     150                 155                 160

 ggt cct aat cta ccc atg gct aca gtt gat ata aaa aat cca gaa atc      763
 Gly Pro Asn Leu Pro Met Ala Thr Val Asp Ile Lys Asn Pro Glu Ile
 165                 170                 175                 180

 aca aca aat aga ttt tat ggt cca caa gtc aac aac atc tcc cat acc      811
 Thr Thr Asn Arg Phe Tyr Gly Pro Gln Val Asn Asn Ile Ser His Thr
                 185                 190                 195

 aaa gaa aag aag aag gga aaa gct aaa aag aag aga tta acc aag gga      859
 Lys Glu Lys Lys Lys Gly Lys Ala Lys Lys Lys Arg Leu Thr Lys Gly
             200                 205                 210

 gat ata gga aca cca agc aat ttc cag cac att gga cat gtt ggt tgg      907
 Asp Ile Gly Thr Pro Ser Asn Phe Gln His Ile Gly His Val Gly Trp
         215                 220                 225

 gat cca aat aca ggc tct gat ctg aat aat ttg gat cca gaa ttg aag      955
 Asp Pro Asn Thr Gly Ser Asp Leu Asn Asn Leu Asp Pro Glu Leu Lys
     230                 235                 240

 aat ctt ttt gat atg tgt gga atc tta gag gca caa ctt aaa gaa aga     1003
 Asn Leu Phe Asp Met Cys Gly Ile Leu Glu Ala Gln Leu Lys Glu Arg
 245                 250                 255                 260

 gaa aca tta aaa gtt ata tat gac ttt att gaa aaa aca gga ggt gtt     1051
 Glu Thr Leu Lys Val Ile Tyr Asp Phe Ile Glu Lys Thr Gly Gly Val
                 265                 270                 275

 gaa gct gtt aaa aat gaa ctg cgg agg caa gca cca cca cct cca cca     1099
 Glu Ala Val Lys Asn Glu Leu Arg Arg Gln Ala Pro Pro Pro Pro Pro
             280                 285                 290

 cca tca agg gga ggg cca cct cct cct cct ccc cct cca cat agc tcg     1147
 Pro Ser Arg Gly Gly Pro Pro Pro Pro Pro Pro Pro Pro His Ser Ser
         295                 300                 305

 ggt cct cct cct cct cct gct agg gga aga ggc gct cct ccc cca cca     1195
 Gly Pro Pro Pro Pro Pro Ala Arg Gly Arg Gly Ala Pro Pro Pro Pro
     310                 315                 320

 cct tca aga gct ccc aca gct gca cct cca cca ccg cct cct tcc agg     1243
 Pro Ser Arg Ala Pro Thr Ala Ala Pro Pro Pro Pro Pro Pro Ser Arg
 325                 330                 335                 340

 cca agt gta gaa gtc cct cca cca ccg cca aat agg atg tac cct cct     1291
 Pro Ser Val Glu Val Pro Pro Pro Pro Pro Asn Arg Met Tyr Pro Pro
                 345                 350                 355

 cca cct cca gcc ctt ccc tcc tca gca cct tca ggg cct cca cca cca     1339
 Pro Pro Pro Ala Leu Pro Ser Ser Ala Pro Ser Gly Pro Pro Pro Pro
             360                 365                 370

 cct cca tct gtg ttg ggg gta ggg cca gtg gca cca ccc cca ccg cct     1387
 Pro Pro Ser Val Leu Gly Val Gly Pro Val Ala Pro Pro Pro Pro Pro
         375                 380                 385

 cca cct cca cct cct cct ggg cca ccg ccc ccg cct ggc ctg cct tct     1435
 Pro Pro Pro Pro Pro Pro Gly Pro Pro Pro Pro Pro Gly Leu Pro Ser
     390                 395                 400

 gat ggg gac cat cag gtt cca act act gca gga aac aaa gca gct ctt     1483
 Asp Gly Asp His Gln Val Pro Thr Thr Ala Gly Asn Lys Ala Ala Leu
 405                 410                 415                 420

 tta gat caa att aga gag ggt gct cag cta aaa aaa gtg gag cag aac     1531
 Leu Asp Gln Ile Arg Glu Gly Ala Gln Leu Lys Lys Val Glu Gln Asn
                 425                 430                 435

 agt cgg cca gtg tcc tgc tct gga cga gat gca ctg tta gac cag ata     1579
 Ser Arg Pro Val Ser Cys Ser Gly Arg Asp Ala Leu Leu Asp Gln Ile
             440                 445                 450

 cga cag ggt atc caa cta aaa tct gtg gct gat ggc caa gag tct aca     1627
 Arg Gln Gly Ile Gln Leu Lys Ser Val Ala Asp Gly Gln Glu Ser Thr
         455                 460                 465

 cca cca aca cct gca ccc act tca gga att gtg ggt gca tta atg gaa     1675
 Pro Pro Thr Pro Ala Pro Thr Ser Gly Ile Val Gly Ala Leu Met Glu
     470                 475                 480

 gtg atg cag aaa agg agc aaa gcc att cat tct tca gat gaa gat gaa     1723
 Val Met Gln Lys Arg Ser Lys Ala Ile His Ser Ser Asp Glu Asp Glu
 485                 490                 495                 500

 gat gaa gat gat gaa gaa gat ttt gag gat gat gat gag tgg gaa gac     1771
 Asp Glu Asp Asp Glu Glu Asp Phe Glu Asp Asp Asp Glu Trp Glu Asp
                 505                 510                 515

 tga tcta tatattatat atatatatat ttttaaggtg aaatactaaa cactactttc     1828
 






      <210> 60
      <211> 4360
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (113)..(4360)

      <400> 60
 atcgtttcgt ccaatttcta aaacaaacaa aaggacaaaa cccattatcg ttgtggcaca     60

 gtccagtttg accttcataa aaccattaaa aacagatatt cccagacacc cg    atg     115
                                                              Met
                                                                1

 cca ttt gct gca aaa aac atg ttt tat gat gaa cgc tgg aag gaa aag      163
 Pro Phe Ala Ala Lys Asn Met Phe Tyr Asp Glu Arg Trp Lys Glu Lys
               5                  10                  15

 cag gaa cag ggc ttc act tgg tgg tta aat ttt ata tta acc cct gat      211
 Gln Glu Gln Gly Phe Thr Trp Trp Leu Asn Phe Ile Leu Thr Pro Asp
          20                  25                  30

 gac ttc act gta aaa aca aat att tct gaa gta aat gct gct act ctt      259
 Asp Phe Thr Val Lys Thr Asn Ile Ser Glu Val Asn Ala Ala Thr Leu
      35                  40                  45

 ctt ttg gga ata gag aat caa cat aaa ata agt gtt cct aga gca cct      307
 Leu Leu Gly Ile Glu Asn Gln His Lys Ile Ser Val Pro Arg Ala Pro
  50                  55                  60                  65

 aca aaa gag gaa atg tct ctc aga gct tat act gct cgg tgt agg tta      355
 Thr Lys Glu Glu Met Ser Leu Arg Ala Tyr Thr Ala Arg Cys Arg Leu
                  70                  75                  80

 aac aga cta cgt cgt gca gca tgc cgt ttg ttt act tct gaa aaa atg      403
 Asn Arg Leu Arg Arg Ala Ala Cys Arg Leu Phe Thr Ser Glu Lys Met
              85                  90                  95

 gtt aaa gct att aaa aag ctt gaa att gaa att gaa gct agg cgg tta      451
 Val Lys Ala Ile Lys Lys Leu Glu Ile Glu Ile Glu Ala Arg Arg Leu
         100                 105                 110

 att gtt cga aaa gat aga cac cta tgg aaa gat gtg gga gaa cgt cag      499
 Ile Val Arg Lys Asp Arg His Leu Trp Lys Asp Val Gly Glu Arg Gln
     115                 120                 125

 aaa gtc ctg aat tgg ctg ttg tcc tac aat cct ttg tgg ctt cga att      547
 Lys Val Leu Asn Trp Leu Leu Ser Tyr Asn Pro Leu Trp Leu Arg Ile
 130                 135                 140                 145

 ggt cta gag aca act tat gga gaa ctc ata tct ttg gaa gat aac agt      595
 Gly Leu Glu Thr Thr Tyr Gly Glu Leu Ile Ser Leu Glu Asp Asn Ser
                 150                 155                 160

 gat gtc aca ggg ttg gct atg ttt att ctg aat cgc cta ctt tgg aat      643
 Asp Val Thr Gly Leu Ala Met Phe Ile Leu Asn Arg Leu Leu Trp Asn
             165                 170                 175

 cct gat ata gca gct gag tat aga cac ccc act gtt cct cac ctg tat      691
 Pro Asp Ile Ala Ala Glu Tyr Arg His Pro Thr Val Pro His Leu Tyr
         180                 185                 190

 aga gat ggt cat gaa gaa gct ttg tcc aag ttt aca ttg aaa aag tta      739
 Arg Asp Gly His Glu Glu Ala Leu Ser Lys Phe Thr Leu Lys Lys Leu
     195                 200                 205

 ttg ttg ttg gtc tgt ttt ctt gat tat gct aaa att tcc aga ctc att      787
 Leu Leu Leu Val Cys Phe Leu Asp Tyr Ala Lys Ile Ser Arg Leu Ile
 210                 215                 220                 225

 gat cat gat cct tgt ctc ttc tgt aaa gat gcc gaa ttc aag gct agt      835
 Asp His Asp Pro Cys Leu Phe Cys Lys Asp Ala Glu Phe Lys Ala Ser
                 230                 235                 240

 aaa gaa atc ctt ttg gct ttt tca cga gat ttc cta agt ggt gaa ggt      883
 Lys Glu Ile Leu Leu Ala Phe Ser Arg Asp Phe Leu Ser Gly Glu Gly
             245                 250                 255

 gac ctt tcc cgt cac ctt ggc tta ttg gga tta cct gtt aac cat gtt      931
 Asp Leu Ser Arg His Leu Gly Leu Leu Gly Leu Pro Val Asn His Val
         260                 265                 270

 cag aca cca ttt gat gaa ttt gat ttt gcc gtt aca aat ctt gcc gta      979
 Gln Thr Pro Phe Asp Glu Phe Asp Phe Ala Val Thr Asn Leu Ala Val
     275                 280                 285

 gac ttg caa tgt gga gtg cgc ctt gtg cga acc atg gaa ctt ctc aca     1027
 Asp Leu Gln Cys Gly Val Arg Leu Val Arg Thr Met Glu Leu Leu Thr
 290                 295                 300                 305

 cag aac tgg gac ctc tca aag aaa ctc agg att ccg gca ata agt cgt     1075
 Gln Asn Trp Asp Leu Ser Lys Lys Leu Arg Ile Pro Ala Ile Ser Arg
                 310                 315                 320

 ctt caa aag atg cac aat gtt gac att gtt ctt caa gtt ctt aaa tca     1123
 Leu Gln Lys Met His Asn Val Asp Ile Val Leu Gln Val Leu Lys Ser
             325                 330                 335

 cga gga att gaa tta agt gat gag cat gga aat aca att cta tct aag     1171
 Arg Gly Ile Glu Leu Ser Asp Glu His Gly Asn Thr Ile Leu Ser Lys
         340                 345                 350

 gat att gtg gat agg cac aga gaa aaa act ctc agg ttg ctt tgg aaa     1219
 Asp Ile Val Asp Arg His Arg Glu Lys Thr Leu Arg Leu Leu Trp Lys
     355                 360                 365

 ata gcg ttt gct ttt cag gtg gat att tcc ctt aac tta gat caa tta     1267
 Ile Ala Phe Ala Phe Gln Val Asp Ile Ser Leu Asn Leu Asp Gln Leu
 370                 375                 380                 385

 aag gaa gaa att gcc ttt cta aaa cac aca aag agt ata aag aaa aca     1315
 Lys Glu Glu Ile Ala Phe Leu Lys His Thr Lys Ser Ile Lys Lys Thr
                 390                 395                 400

 ata tct cta cta tca tgc cat tct gat gat ctt att aat aag aaa aaa     1363
 Ile Ser Leu Leu Ser Cys His Ser Asp Asp Leu Ile Asn Lys Lys Lys
             405                 410                 415

 ggc aaa agg gat agt ggt tcc ttt gaa caa tat agt gaa aac ata aag     1411
 Gly Lys Arg Asp Ser Gly Ser Phe Glu Gln Tyr Ser Glu Asn Ile Lys
         420                 425                 430

 tta ttg atg gat tgg gta aat gct gtt tgt gcc ttc tat aat aaa aag     1459
 Leu Leu Met Asp Trp Val Asn Ala Val Cys Ala Phe Tyr Asn Lys Lys
     435                 440                 445

 gtg gag aat ttt aca gtg tct ttc tca gac ggc cgt gtg tta tgt tac     1507
 Val Glu Asn Phe Thr Val Ser Phe Ser Asp Gly Arg Val Leu Cys Tyr
 450                 455                 460                 465

 ctg atc cac cat tac cat cct tgc tat gtg cca tta gac gct ata tgt     1555
 Leu Ile His His Tyr His Pro Cys Tyr Val Pro Leu Asp Ala Ile Cys
                 470                 475                 480

 cag cgt act act caa act gtg gaa tgt acg caa act ggt tca gtg gta     1603
 Gln Arg Thr Thr Gln Thr Val Glu Cys Thr Gln Thr Gly Ser Val Val
             485                 490                 495

 tta aat tca tca tct gaa tct gat gac agt tct ctg gat atg tca ctt     1651
 Leu Asn Ser Ser Ser Glu Ser Asp Asp Ser Ser Leu Asp Met Ser Leu
         500                 505                 510

 aaa gca ttt gat cat gaa aat act tca gag cta tac aaa gag ctc cta     1699
 Lys Ala Phe Asp His Glu Asn Thr Ser Glu Leu Tyr Lys Glu Leu Leu
     515                 520                 525

 gaa aat gaa aag aaa aat ttt cac ttg gtt agg tct gca gtt aga gac     1747
 Glu Asn Glu Lys Lys Asn Phe His Leu Val Arg Ser Ala Val Arg Asp
 530                 535                 540                 545

 ctt ggt gga ata cct gct atg att aat cat tca gat atg tca aat aca     1795
 Leu Gly Gly Ile Pro Ala Met Ile Asn His Ser Asp Met Ser Asn Thr
                 550                 555                 560

 att cca gat gaa aag gtg gtt att acc tat ttg tca ttt ctt tgt gca     1843
 Ile Pro Asp Glu Lys Val Val Ile Thr Tyr Leu Ser Phe Leu Cys Ala
             565                 570                 575

 agg ctt ttg gat ctt cgt aaa gaa ata aga gct gct cga ctc ata caa     1891
 Arg Leu Leu Asp Leu Arg Lys Glu Ile Arg Ala Ala Arg Leu Ile Gln
         580                 585                 590

 aca aca tgg aga aaa tat aaa cta aaa aca gat ctc aaa cgc cat cag     1939
 Thr Thr Trp Arg Lys Tyr Lys Leu Lys Thr Asp Leu Lys Arg His Gln
     595                 600                 605

 gag aga gag aaa gct gca aga att att caa ttg gct gta atc aat ttt     1987
 Glu Arg Glu Lys Ala Ala Arg Ile Ile Gln Leu Ala Val Ile Asn Phe
 610                 615                 620                 625

 cta gca aaa caa aga ttg aga aaa aga gtt aat gca gca ctc gtc att     2035
 Leu Ala Lys Gln Arg Leu Arg Lys Arg Val Asn Ala Ala Leu Val Ile
                 630                 635                 640

 cag aaa tat tgg cga aga gtc tta gca cag aga aaa tta tta atg tta     2083
 Gln Lys Tyr Trp Arg Arg Val Leu Ala Gln Arg Lys Leu Leu Met Leu
             645                 650                 655

 aaa aag gaa aag ctg gaa aaa gtt caa aat aaa gca gca tca ctt att     2131
 Lys Lys Glu Lys Leu Glu Lys Val Gln Asn Lys Ala Ala Ser Leu Ile
         660                 665                 670

 cag gga tat tgg aga aga tat tcc act aga caa aga ttt ctg aaa ttg     2179
 Gln Gly Tyr Trp Arg Arg Tyr Ser Thr Arg Gln Arg Phe Leu Lys Leu
     675                 680                 685

 aaa tat tat tca atc atc ctg caa tct agg ata aga atg ata att gct     2227
 Lys Tyr Tyr Ser Ile Ile Leu Gln Ser Arg Ile Arg Met Ile Ile Ala
 690                 695                 700                 705

 gtt aca tct tat aaa cga tat ctt tgg gct aca gtt aca att cag agg     2275
 Val Thr Ser Tyr Lys Arg Tyr Leu Trp Ala Thr Val Thr Ile Gln Arg
                 710                 715                 720

 cat tgg cgt gct tat tta aga aga aaa caa gat caa caa aga tat gaa     2323
 His Trp Arg Ala Tyr Leu Arg Arg Lys Gln Asp Gln Gln Arg Tyr Glu
             725                 730                 735

 atg cta aaa tca tca act ctt ata atc caa tct atg ttc aga aaa tgg     2371
 Met Leu Lys Ser Ser Thr Leu Ile Ile Gln Ser Met Phe Arg Lys Trp
         740                 745                 750

 aag caa cgt aaa atg caa tca caa gta aaa gct aca gta ata ttg caa     2419
 Lys Gln Arg Lys Met Gln Ser Gln Val Lys Ala Thr Val Ile Leu Gln
     755                 760                 765

 aga gct ttt aga gaa tgg cat tta aga aaa caa gct aaa gaa gaa aat     2467
 Arg Ala Phe Arg Glu Trp His Leu Arg Lys Gln Ala Lys Glu Glu Asn
 770                 775                 780                 785

 tct gct att atc ata caa tca tgg tat aga atg cat aaa gaa tta cgg     2515
 Ser Ala Ile Ile Ile Gln Ser Trp Tyr Arg Met His Lys Glu Leu Arg
                 790                 795                 800

 aaa tat att tat att aga tct tgt gtt gtt atc att cag aaa aga ttt     2563
 Lys Tyr Ile Tyr Ile Arg Ser Cys Val Val Ile Ile Gln Lys Arg Phe
             805                 810                 815

 cgg tgc ttt caa gcc caa aag tta tat aaa aaa aaa aaa gag tcc ata     2611
 Arg Cys Phe Gln Ala Gln Lys Leu Tyr Lys Lys Lys Lys Glu Ser Ile
         820                 825                 830

 cta acc atc cag aag tac tac aaa gca tat ctg aaa gga aag att gag     2659
 Leu Thr Ile Gln Lys Tyr Tyr Lys Ala Tyr Leu Lys Gly Lys Ile Glu
     835                 840                 845

 cgc acc aac tat ttg cag aaa cga gct gca gcc att caa tta caa gct     2707
 Arg Thr Asn Tyr Leu Gln Lys Arg Ala Ala Ala Ile Gln Leu Gln Ala
 850                 855                 860                 865

 gct ttt agg aga ctg aaa gct cat aat tta tgt aga caa att aga gct     2755
 Ala Phe Arg Arg Leu Lys Ala His Asn Leu Cys Arg Gln Ile Arg Ala
                 870                 875                 880

 gct tgt gtt att cag tca tac tgg aga atg aga caa gac aga gtt cga     2803
 Ala Cys Val Ile Gln Ser Tyr Trp Arg Met Arg Gln Asp Arg Val Arg
             885                 890                 895

 ttt tta aac ctt aag aag act att atc aaa ttt cag gca cat gta aga     2851
 Phe Leu Asn Leu Lys Lys Thr Ile Ile Lys Phe Gln Ala His Val Arg
         900                 905                 910

 aaa cat caa caa cga cag aaa tat aag aag atg aag aaa gca gct gtt     2899
 Lys His Gln Gln Arg Gln Lys Tyr Lys Lys Met Lys Lys Ala Ala Val
     915                 920                 925

 ata att cag act cat ttc cga gct tat att ttt gcc atg aaa gtt cta     2947
 Ile Ile Gln Thr His Phe Arg Ala Tyr Ile Phe Ala Met Lys Val Leu
 930                 935                 940                 945

 gca tct tac cag aaa aca cgc tct gct gtc att gtg ctg cag tct gca     2995
 Ala Ser Tyr Gln Lys Thr Arg Ser Ala Val Ile Val Leu Gln Ser Ala
                 950                 955                 960

 tat aga ggg atg caa gcc agg aaa atg tat att cac atc ctc aca tct     3043
 Tyr Arg Gly Met Gln Ala Arg Lys Met Tyr Ile His Ile Leu Thr Ser
             965                 970                 975

 gtt ata aag att caa tca tat tat cgt gct tat gtt tct aaa aag gaa     3091
 Val Ile Lys Ile Gln Ser Tyr Tyr Arg Ala Tyr Val Ser Lys Lys Glu
         980                 985                 990

 ttt ttg agc cta aaa aat gct aca ata aaa ttg cag tca act gtt aag     3139
 Phe Leu Ser Leu Lys Asn Ala Thr Ile Lys Leu Gln Ser Thr Val Lys
     995                1000                1005

 atg aaa caa aca cgt aaa caa tat ttg cat tta aga gca gct gca cta     3187
 Met Lys Gln Thr Arg Lys Gln Tyr Leu His Leu Arg Ala Ala Ala Leu
1010                1015                1020                1025

 ttt atc cag caa tgt tac cgt tcc aaa aaa ata gct gca caa aag aga     3235
 Phe Ile Gln Gln Cys Tyr Arg Ser Lys Lys Ile Ala Ala Gln Lys Arg
                1030                1035                1040

 gaa gag tat atg cag atg cgg gaa tct tgt atc aaa ctg caa gca ttt     3283
 Glu Glu Tyr Met Gln Met Arg Glu Ser Cys Ile Lys Leu Gln Ala Phe
            1045                1050                1055

 gtt aga gga tac ctt gtc cga aag cag atg agg tta caa aga aaa gct     3331
 Val Arg Gly Tyr Leu Val Arg Lys Gln Met Arg Leu Gln Arg Lys Ala
        1060                1065                1070

 gtt att tca cta cag tct tat ttc aga atg aga aag gct cgg cag tat     3379
 Val Ile Ser Leu Gln Ser Tyr Phe Arg Met Arg Lys Ala Arg Gln Tyr
    1075                1080                1085

 tat ctg aaa atg tat aaa gca att att gtc att cag aat tac tat cat     3427
 Tyr Leu Lys Met Tyr Lys Ala Ile Ile Val Ile Gln Asn Tyr Tyr His
1090                1095                1100                1105

 gca tac aaa gca cag gtc aat cag agg aag aac ttc ttg caa gtc aaa     3475
 Ala Tyr Lys Ala Gln Val Asn Gln Arg Lys Asn Phe Leu Gln Val Lys
                1110                1115                1120

 aaa gca gct act tgc ttg caa gca gct tac aga ggt tat aaa att cag     3523
 Lys Ala Ala Thr Cys Leu Gln Ala Ala Tyr Arg Gly Tyr Lys Ile Gln
            1125                1130                1135

 aga tgg tac agg gcg tac aag act ctt cat gat aca aga aca cat ttt     3571
 Arg Trp Tyr Arg Ala Tyr Lys Thr Leu His Asp Thr Arg Thr His Phe
        1140                1145                1150

 ttg aag aca aag gca gct gtg att tcc ctc cag tct gct tat cgt ggc     3619
 Leu Lys Thr Lys Ala Ala Val Ile Ser Leu Gln Ser Ala Tyr Arg Gly
    1155                1160                1165

 tgg aag gtt cgg aaa cag att aga agg gaa cat caa gct gcc ttg aag     3667
 Trp Lys Val Arg Lys Gln Ile Arg Arg Glu His Gln Ala Ala Leu Lys
1170                1175                1180                1185

 att cag tct gct ttt aga atg gcc aag gcc cag aaa cag ttt aga ttg     3715
 Ile Gln Ser Ala Phe Arg Met Ala Lys Ala Gln Lys Gln Phe Arg Leu
                1190                1195                1200

 ttt aaa aca gca gca tta gtc atc cag caa aat ttc aga gca tgg act     3763
 Phe Lys Thr Ala Ala Leu Val Ile Gln Gln Asn Phe Arg Ala Trp Thr
            1205                1210                1215

 gca gga agg aag caa tgt atg gag tat att gaa ctc cgt cat gcg gta     3811
 Ala Gly Arg Lys Gln Cys Met Glu Tyr Ile Glu Leu Arg His Ala Val
        1220                1225                1230

 ctg gtg ctt caa tct atg tgg aag gga aaa aca ctg aga aga cag ctt     3859
 Leu Val Leu Gln Ser Met Trp Lys Gly Lys Thr Leu Arg Arg Gln Leu
    1235                1240                1245

 caa agg caa cat aaa tgt gct atc atc ata cag tca tac tat aga atg     3907
 Gln Arg Gln His Lys Cys Ala Ile Ile Ile Gln Ser Tyr Tyr Arg Met
1250                1255                1260                1265

 cat gtg caa caa aag aag tgg aaa atc atg aaa aaa gct gct ctt ctg     3955
 His Val Gln Gln Lys Lys Trp Lys Ile Met Lys Lys Ala Ala Leu Leu
                1270                1275                1280

 att caa aag tat tat agg gct tac agt att gga aga gaa cag aat cat     4003
 Ile Gln Lys Tyr Tyr Arg Ala Tyr Ser Ile Gly Arg Glu Gln Asn His
            1285                1290                1295

 tta tat ttg aaa aca aaa gca gct gta gta act tta cag tca gct tat     4051
 Leu Tyr Leu Lys Thr Lys Ala Ala Val Val Thr Leu Gln Ser Ala Tyr
        1300                1305                1310

 cgt ggt atg aaa gtg aga aaa aga ata aag gat tgc aac aaa gca gca     4099
 Arg Gly Met Lys Val Arg Lys Arg Ile Lys Asp Cys Asn Lys Ala Ala
    1315                1320                1325

 gtc act ata cag tct aaa tac aga gct tac aaa acc aaa aag aaa tat     4147
 Val Thr Ile Gln Ser Lys Tyr Arg Ala Tyr Lys Thr Lys Lys Lys Tyr
1330                1335                1340                1345

 gca acc tat aga gct tca gct att ata att cag aga tgg tat cga ggt     4195
 Ala Thr Tyr Arg Ala Ser Ala Ile Ile Ile Gln Arg Trp Tyr Arg Gly
                1350                1355                1360

 att aaa att aca aac cat cag cat aag gag tat ctt aat ttg aag aag     4243
 Ile Lys Ile Thr Asn His Gln His Lys Glu Tyr Leu Asn Leu Lys Lys
            1365                1370                1375

 aca gca att aaa atc caa tct gtt tat aga gta tta gag tta gaa gac     4291
 Thr Ala Ile Lys Ile Gln Ser Val Tyr Arg Val Leu Glu Leu Glu Asp
        1380                1385                1390

 ata ttc aac aca tgc aca ggg cag cca ctt gta tta aag cca tgt tta     4339
 Ile Phe Asn Thr Cys Thr Gly Gln Pro Leu Val Leu Lys Pro Cys Leu
    1395                1400                1405

 aaa tgc atc agt caa gaa taa                                         4360
 Lys Cys Ile Ser Gln Glu 
1410                1415





      <210> 61
      <211> 584
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (13)..(537)

      <400> 61
 cggcacgaga aa    atg gcg act gtg gca gag ttg aag gct gtt tta aag      48
                  Met Ala Thr Val Ala Glu Leu Lys Ala Val Leu Lys
                    1               5                  10

 gac acc ttg gaa aaa aag ggg gta tta ggg cat tta aaa gca agg atc       96
 Asp Thr Leu Glu Lys Lys Gly Val Leu Gly His Leu Lys Ala Arg Ile
          15                  20                  25

 cga gct gaa gtt ttc aat gcc cta gat gat gac cgt gaa ccc cga cca      144
 Arg Ala Glu Val Phe Asn Ala Leu Asp Asp Asp Arg Glu Pro Arg Pro
      30                  35                  40

 tca ttg tct cat gaa aac ctt cta att aat gaa tta att cga gag tat      192
 Ser Leu Ser His Glu Asn Leu Leu Ile Asn Glu Leu Ile Arg Glu Tyr
  45                  50                  55                  60

 tta gaa ttc aac aaa tat aag tat aca gca tct gtc ctc ata gca gaa      240
 Leu Glu Phe Asn Lys Tyr Lys Tyr Thr Ala Ser Val Leu Ile Ala Glu
                  65                  70                  75

 tct ggt caa cct gta gtt ccg ttg gac aga cag ttt ctc atc cat gaa      288
 Ser Gly Gln Pro Val Val Pro Leu Asp Arg Gln Phe Leu Ile His Glu
              80                  85                  90

 cta aat gca ttt gaa gaa tca aag gat aat aca ata cct ctt tta tat      336
 Leu Asn Ala Phe Glu Glu Ser Lys Asp Asn Thr Ile Pro Leu Leu Tyr
          95                 100                 105

 ggg att tta gcc cat ttc ttg cgt gga act aag gat ggc atc cag aat      384
 Gly Ile Leu Ala His Phe Leu Arg Gly Thr Lys Asp Gly Ile Gln Asn
     110                 115                 120

 gca ttt ctg aaa ggg cct tca ctt cag cct tca gac cca agt ctt ggc      432
 Ala Phe Leu Lys Gly Pro Ser Leu Gln Pro Ser Asp Pro Ser Leu Gly
 125                 130                 135                 140

 aga caa cct agt aga aga aag cca atg gat gac cac cta aga aag gag      480
 Arg Gln Pro Ser Arg Arg Lys Pro Met Asp Asp His Leu Arg Lys Glu
                 145                 150                 155

 gaa cag aaa agt act aac att gaa gat ctt cat gtt tct cag gca gtc      528
 Glu Gln Lys Ser Thr Asn Ile Glu Asp Leu His Val Ser Gln Ala Val
             160                 165                 170

 aac aga taa tgctttg tttggggtat cttttgtctt aaaattgtat tattaattaa      584
 Asn Arg 






      <210> 62
      <211> 1211
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (28)..(1164)

      <400> 62
 ggctaggtac gaggccgggg gtgacag    atg gcc gac gcg gcg gcc aca gct      51
                                  Met Ala Asp Ala Ala Ala Thr Ala
                                    1               5

 ggg gcc ggt ggc tcc gga acg aga tcg gga agt aaa cag tcc act aac       99
 Gly Ala Gly Gly Ser Gly Thr Arg Ser Gly Ser Lys Gln Ser Thr Asn
      10                  15                  20

 cct gcc gat aac tat cat ctg gcc cgg agg aga acc ctg cag gtg gtt      147
 Pro Ala Asp Asn Tyr His Leu Ala Arg Arg Arg Thr Leu Gln Val Val
  25                  30                  35                  40

 gtg agc tcc ttg ctg aca gag gca ggg ttt gag agt gcc gag aaa gca      195
 Val Ser Ser Leu Leu Thr Glu Ala Gly Phe Glu Ser Ala Glu Lys Ala
                  45                  50                  55

 tcc gtg gaa acg ctg aca gag atg ctg cag agc tac att tca gaa att      243
 Ser Val Glu Thr Leu Thr Glu Met Leu Gln Ser Tyr Ile Ser Glu Ile
              60                  65                  70

 ggg aga agt gcc aag tct tac tgt gag cac aca gcc agg acc cag ccc      291
 Gly Arg Ser Ala Lys Ser Tyr Cys Glu His Thr Ala Arg Thr Gln Pro
          75                  80                  85

 aca ctg tcc gat atc gtg gtc aca ctt gtt gag atg ggt ttc aat gtg      339
 Thr Leu Ser Asp Ile Val Val Thr Leu Val Glu Met Gly Phe Asn Val
      90                  95                 100

 gac act ctc cct gct tat gca aaa cgg tct cag agg atg gtc atc act      387
 Asp Thr Leu Pro Ala Tyr Ala Lys Arg Ser Gln Arg Met Val Ile Thr
 105                 110                 115                 120

 gct cct ccg gtg acc aat cag cca gtg acc ccc aag gcc ctc act gca      435
 Ala Pro Pro Val Thr Asn Gln Pro Val Thr Pro Lys Ala Leu Thr Ala
                 125                 130                 135

 ggg cag aac cga ccc cac ccg ccg cac atc ccc agc cat ttt cct gag      483
 Gly Gln Asn Arg Pro His Pro Pro His Ile Pro Ser His Phe Pro Glu
             140                 145                 150

 ttc cct gat ccc cac acc tac atc aaa act ccg acg tac cgt gag ccc      531
 Phe Pro Asp Pro His Thr Tyr Ile Lys Thr Pro Thr Tyr Arg Glu Pro
         155                 160                 165

 gtg tca gac tac cag gtc ctg cgg gag aag gct gca tcc cag agg cgc      579
 Val Ser Asp Tyr Gln Val Leu Arg Glu Lys Ala Ala Ser Gln Arg Arg
     170                 175                 180

 gat gtg gag cgg gca ctt acc cgt ttc atg gcc aag aca ggc gag act      627
 Asp Val Glu Arg Ala Leu Thr Arg Phe Met Ala Lys Thr Gly Glu Thr
 185                 190                 195                 200

 cag agt ctt ttc aaa gat gac gtc agc aca ttt cca ttg att gct gcc      675
 Gln Ser Leu Phe Lys Asp Asp Val Ser Thr Phe Pro Leu Ile Ala Ala
                 205                 210                 215

 aga cct ttc acc atc ccc tac ctg aca gct ctt ctt ccg tct gaa ctg      723
 Arg Pro Phe Thr Ile Pro Tyr Leu Thr Ala Leu Leu Pro Ser Glu Leu
             220                 225                 230

 gag atg caa caa atg gaa gag aca gat tcc tcg gag cag gat gaa cag      771
 Glu Met Gln Gln Met Glu Glu Thr Asp Ser Ser Glu Gln Asp Glu Gln
         235                 240                 245

 aca gac aca gag aac ctt gct ctt cat atc agc atg ata ggc att acc      819
 Thr Asp Thr Glu Asn Leu Ala Leu His Ile Ser Met Ile Gly Ile Thr
     250                 255                 260

 aat gat gtg cat gtg ctg gta cct gct ggc tct gcg tcc ctt agt gga      867
 Asn Asp Val His Val Leu Val Pro Ala Gly Ser Ala Ser Leu Ser Gly
 265                 270                 275                 280

 acc ctc aag gct caa gaa gtt tct agc ctg tgc tgg gat gtg att gtt      915
 Thr Leu Lys Ala Gln Glu Val Ser Ser Leu Cys Trp Asp Val Ile Val
                 285                 290                 295

 ggt acc atg ttg caa gta cca gaa atg gat gag tct gtt tcc tct gtg      963
 Gly Thr Met Leu Gln Val Pro Glu Met Asp Glu Ser Val Ser Ser Val
             300                 305                 310

 cat gtt gaa ctg att gat gca gtt tat ttt gct ctt ttt ctc agc atg     1011
 His Val Glu Leu Ile Asp Ala Val Tyr Phe Ala Leu Phe Leu Ser Met
         315                 320                 325

 gag gat tct gga gcc gag aag gag aac acc tct gtc ctg cag cag aac     1059
 Glu Asp Ser Gly Ala Glu Lys Glu Asn Thr Ser Val Leu Gln Gln Asn
     330                 335                 340

 ccc tcc ttg tcg ggt agc cgg aat ggg gag gag aac atc atc gat aac     1107
 Pro Ser Leu Ser Gly Ser Arg Asn Gly Glu Glu Asn Ile Ile Asp Asn
 345                 350                 355                 360

 cct tat ctg cga ccg gtg aag aag ccc aag atc cgc agg aag aag tcc     1155
 Pro Tyr Leu Arg Pro Val Lys Lys Pro Lys Ile Arg Arg Lys Lys Ser
                 365                 370                 375

 ctc tcc tga gctgaga aggaaacctg gcttgtacag gggcgcagat tccaccctcc     1211
 Leu Ser 






      <210> 63
      <211> 2043
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1165)..(1923)

      <400> 63
 aatgggcatc tgtttccacc agtcaccagc aagtgaagga tcgtataagg acacccttca     60

 gtgtcagtgt gcttcactat gctcaaaatc accggatttg gaggtggatg tggagggact    120

 cgggcgacag ggtggtgaag tcaggctgtg gccccagcgg cgccacgagg ccgagaaccg    180

 gcgctcagcc tcatccctgt ggctgcagag tgccaagcgc caggtcctgc actctgggcg    240

 cgggtcagga gcagctggca agggcagcgc agcctgtggg gcccttgggc gtggccggcc    300

 gcagctccgg gaagccacgt cagcccacgg gcgctgcagc tgcagccgcc accagcacat    360

 ggagcagggg tccccgagga ttgggaatcc ccgaccaggc ctgcgcctcc agccgcgcgg    420

 accccggggc cagcctggcc gcggcaagtc aggcagtctg cggcaggagc gccgggcatg    480

 ggcttccgcc gggggtgcag gaggcgcgca ccctccggcc ggatgggggc gcactcaggg    540

 cccaggaggc catcccacgg gagccccgcc agcccccgcc ggagcccgag ctgcagtgcc    600

 gcctacaagt ggtgcgctgg ctgcagctgt ggcaaccccg gatcccgtcc tcccgcctcg    660

 cacccatcag cgcggacccc gggggcgacg cagtggcgaa gtggggctgt gggcccagcg    720

 gtggcaccag gcggagaagc accactcaac cccatccctg ggctgcagag ggcccagcgc    780

 gggggactcc gagcgtcggg agcctgtgga agagaagagc gcgcgggcga cagttaaaca    840

 ggccctgggg cagggcgcgc ctcggcttcc agggagcccc gccctcccgc ggcacctccg    900

 cagcaaccgc cgcctgcact gggcgcgcga gagctgctag ggcggtttct ctgcctcggg    960

 cctgttgggc agggccggct aaggtgcgcg tgctcgctgg ttctaaccct tctgttgggc   1020

 gtttctgctg agaggcggga ggcgctgaga gtctgtgcgg aggtccgtgg acagactgct   1080

 ttgctcgttg ttgctcttcg gaggcggcga tccccgaagg cgagctgaaa tacggctgca   1140

 ggctacaatt tgcagccgac gatt   atg gaa gac ggc aag cgg gag agg tgg    1191
                              Met Glu Asp Gly Lys Arg Glu Arg Trp
                                1               5

 ccc acc ctc atg gag cgc ttg tgc tcg gat ggc ttc gca ttt ccc caa     1239
 Pro Thr Leu Met Glu Arg Leu Cys Ser Asp Gly Phe Ala Phe Pro Gln
  10                  15                  20                  25

 tac ccc att aaa ccg tat cat ctg aat agg atc cac aga gct gtc tta     1287
 Tyr Pro Ile Lys Pro Tyr His Leu Asn Arg Ile His Arg Ala Val Leu
                  30                  35                  40

 cat ggt aat cta gag aaa ctg aag tac ctt ctg ctc acg tat tat gac     1335
 His Gly Asn Leu Glu Lys Leu Lys Tyr Leu Leu Leu Thr Tyr Tyr Asp
              45                  50                  55

 gcc aat aag aga gac agg aag gaa agg acc gcc cta cat ttg gcc tgt     1383
 Ala Asn Lys Arg Asp Arg Lys Glu Arg Thr Ala Leu His Leu Ala Cys
          60                  65                  70

 gcc act ggc caa ccg gaa atg gta cat ctc ctg gtg tcc aga aga tgt     1431
 Ala Thr Gly Gln Pro Glu Met Val His Leu Leu Val Ser Arg Arg Cys
      75                  80                  85

 gag ctt aac ctc tgc gac cgt gaa gac agg aca cct ctg atc aag gct     1479
 Glu Leu Asn Leu Cys Asp Arg Glu Asp Arg Thr Pro Leu Ile Lys Ala
  90                  95                 100                 105

 gta caa ctg agg cag gag gct tgt gca act ctt ctg ctg caa aat ggc     1527
 Val Gln Leu Arg Gln Glu Ala Cys Ala Thr Leu Leu Leu Gln Asn Gly
                 110                 115                 120

 gcc gat cca aat att acg gat gtc ttt gga agg act gct ctg caa cta     1575
 Ala Asp Pro Asn Ile Thr Asp Val Phe Gly Arg Thr Ala Leu Gln Leu
             125                 130                 135

 cgc tgg tgt ata atg aag gat aca tcc atg ata gaa aaa ctt ctt tca     1623
 Arg Trp Cys Ile Met Lys Asp Thr Ser Met Ile Glu Lys Leu Leu Ser
         140                 145                 150

 cat ggt aca aat att gaa gaa tgc agc aag aat gaa tat cag cca ctg     1671
 His Gly Thr Asn Ile Glu Glu Cys Ser Lys Asn Glu Tyr Gln Pro Leu
     155                 160                 165

 tta ctt gct gtg agt cga aga aaa gtg aaa atg gtg gaa ttt tta tta     1719
 Leu Leu Ala Val Ser Arg Arg Lys Val Lys Met Val Glu Phe Leu Leu
 170                 175                 180                 185

 aag aaa aaa gca aat gta aat gcc att gat tat ctt ggc aga tca gcc     1767
 Lys Lys Lys Ala Asn Val Asn Ala Ile Asp Tyr Leu Gly Arg Ser Ala
                 190                 195                 200

 ctc ata ctt gct gtt act ctt gga gaa aaa gat ata gtc att ctt ctt     1815
 Leu Ile Leu Ala Val Thr Leu Gly Glu Lys Asp Ile Val Ile Leu Leu
             205                 210                 215

 ctg cag cac aat att gat gtg ttt tct cga gat gtg tat gga aag ctt     1863
 Leu Gln His Asn Ile Asp Val Phe Ser Arg Asp Val Tyr Gly Lys Leu
         220                 225                 230

 gca gaa gat tat gcc agt gag gct gag aat aga gtt gtc tcc tca gaa     1911
 Ala Glu Asp Tyr Ala Ser Glu Ala Glu Asn Arg Val Val Ser Ser Glu
     235                 240                 245

 aca acc agc tga gaa gtgtcttctc agaaacaacc agctgagaag gctacaagtg     1966
 Thr Thr Ser 
 250

 acgagaaaga ttctgtttca aatatagcca cagaaataaa ggagggacaa caatctggga   2026

 cagtgtctcc tcagaaa                                                  2043




      <210> 64
      <211> 798
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(798)

      <400> 64
  atg gag atc tgc ccc ggg gaa ggc agg gtt tct gcc caa acg gag cca      48
  Met Glu Ile Cys Pro Gly Glu Gly Arg Val Ser Ala Gln Thr Glu Pro
    1               5                  10                  15

 cgt gag gac gtc ttt ggg gat gtg tct cca aga aaa gtg tgg gct gcc       96
 Arg Glu Asp Val Phe Gly Asp Val Ser Pro Arg Lys Val Trp Ala Ala
              20                  25                  30

 ttc ctc acc ctg gat gcc tgt ggg ctg cct tcc tca ccc tgg atg cct      144
 Phe Leu Thr Leu Asp Ala Cys Gly Leu Pro Ser Ser Pro Trp Met Pro
          35                  40                  45

 gtg ggc tgc ctt cct cac cct gga tgc ctg tgg gca gcc ttc ctc acc      192
 Val Gly Cys Leu Pro His Pro Gly Cys Leu Trp Ala Ala Phe Leu Thr
      50                  55                  60

 ctg gat gcc tgt ggg ctg cct tcc tca ccc tgg atg cct gtg ggc tgc      240
 Leu Asp Ala Cys Gly Leu Pro Ser Ser Pro Trp Met Pro Val Gly Cys
  65                  70                  75                  80

 ctt cct cac cct gga tgc ctg tgg gca gcc ttc ctc acc ctg gat gcc      288
 Leu Pro His Pro Gly Cys Leu Trp Ala Ala Phe Leu Thr Leu Asp Ala
                  85                  90                  95

 tgt ggg ctg cct tcc tca ccc tgg atg cct gtg ggc agc ctt cct cac      336
 Cys Gly Leu Pro Ser Ser Pro Trp Met Pro Val Gly Ser Leu Pro His
             100                 105                 110

 cct gga tgc ctg tgg gct gcc ttc ctc acc ctg gat gcc tgt ggg cag      384
 Pro Gly Cys Leu Trp Ala Ala Phe Leu Thr Leu Asp Ala Cys Gly Gln
         115                 120                 125

 cct tcc tca ccc tgg atg cct gtg ggc tgc ctt cct cac cct gga tgc      432
 Pro Ser Ser Pro Trp Met Pro Val Gly Cys Leu Pro His Pro Gly Cys
     130                 135                 140

 ctg tgg gca gcc ttc ctc acc ctg gat gcc tgt ggg cag cct tcc tca      480
 Leu Trp Ala Ala Phe Leu Thr Leu Asp Ala Cys Gly Gln Pro Ser Ser
 145                 150                 155                 160

 ccc tgg atg cct gtg act tgg ttt cca tgg ggg ctt cct aag ctc agg      528
 Pro Trp Met Pro Val Thr Trp Phe Pro Trp Gly Leu Pro Lys Leu Arg
                 165                 170                 175

 gac ccc aag cct cca tca aat cta atg acc cgc cct gtc tct gaa cac      576
 Asp Pro Lys Pro Pro Ser Asn Leu Met Thr Arg Pro Val Ser Glu His
             180                 185                 190

 acc tgt gtt gtc ccc gag ccc ctc acc aac ccc ctc tgc aac ccg gcc      624
 Thr Cys Val Val Pro Glu Pro Leu Thr Asn Pro Leu Cys Asn Pro Ala
         195                 200                 205

 cac gca ttt ccc atc ctg aag ggt cca gct cat agg ccg gcc cat gtg      672
 His Ala Phe Pro Ile Leu Lys Gly Pro Ala His Arg Pro Ala His Val
     210                 215                 220

 ttc cct tta ccc ctg ctt tgt ccc tac ctg gtg ggg agc tgt ccc ttc      720
 Phe Pro Leu Pro Leu Leu Cys Pro Tyr Leu Val Gly Ser Cys Pro Phe
 225                 230                 235                 240

 tgg gcc cta gtg tgg cac ttc aca cac aaa tgt gtc ctg tgg gtg gta      768
 Trp Ala Leu Val Trp His Phe Thr His Lys Cys Val Leu Trp Val Val
                 245                 250                 255

 tct ggg cct ccc cct gca gtg agg gga tga                              798
 Ser Gly Pro Pro Pro Ala Val Arg Gly 
             260                 265





      <210> 65
      <211> 2882
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (144)..(2744)

      <400> 65
 gaacaaatct aaaagaagct gccagacttg gtattcacac cattaaggtt aatgacccag     60

 agactgcagt aaaggaatta gaagctctct tgggttttac attgagagta ggtgttccaa    120

 acactcggcc tgtgaaaaag acg    atg gaa att ccg aaa gat tcc ttg cag     170
                              Met Glu Ile Pro Lys Asp Ser Leu Gln
                                1               5

 aag tac ctc aaa gac tta ctg ggt atc cag acc aca ggc cca ttg gaa      218
 Lys Tyr Leu Lys Asp Leu Leu Gly Ile Gln Thr Thr Gly Pro Leu Glu
  10                  15                  20                  25

 cta ctt cag ttt gat cac ggg cag tca aat cca act tac tac atc agg      266
 Leu Leu Gln Phe Asp His Gly Gln Ser Asn Pro Thr Tyr Tyr Ile Arg
                  30                  35                  40

 ctg gct aat cgt gat cta gtt ctg agg aag aag ccc cca ggg aca ctc      314
 Leu Ala Asn Arg Asp Leu Val Leu Arg Lys Lys Pro Pro Gly Thr Leu
              45                  50                  55

 ctt cca tct gcc cat gcc ata gag agg gag ttc agg att atg aaa gcc      362
 Leu Pro Ser Ala His Ala Ile Glu Arg Glu Phe Arg Ile Met Lys Ala
          60                  65                  70

 ctt gca aat gct gga gta cct gtc cct aac gtt ctt gat ctc tgt gaa      410
 Leu Ala Asn Ala Gly Val Pro Val Pro Asn Val Leu Asp Leu Cys Glu
      75                  80                  85

 gat tca agt gtc att ggc acc ccc ttc tat gtg atg gag tac tgc cca      458
 Asp Ser Ser Val Ile Gly Thr Pro Phe Tyr Val Met Glu Tyr Cys Pro
  90                  95                 100                 105

 ggt ctc atc tac aaa gac cct tcc ctg cca ggc ttg gag ccc agc cac      506
 Gly Leu Ile Tyr Lys Asp Pro Ser Leu Pro Gly Leu Glu Pro Ser His
                 110                 115                 120

 aga cga gcc ata tac act gcc atg aac aca gtc ctg tgc aaa att cac      554
 Arg Arg Ala Ile Tyr Thr Ala Met Asn Thr Val Leu Cys Lys Ile His
             125                 130                 135

 agt gtg gat ctg cag gct gtg gga ctt gaa gac tat ggg aag caa ggg      602
 Ser Val Asp Leu Gln Ala Val Gly Leu Glu Asp Tyr Gly Lys Gln Gly
         140                 145                 150

 gac tat att cca cgc cag gta cga acc tgg gtt aag cag tat cga gct      650
 Asp Tyr Ile Pro Arg Gln Val Arg Thr Trp Val Lys Gln Tyr Arg Ala
     155                 160                 165

 tcc gaa act agc acc atc cca gcc atg gag agg ctg atc gaa tgg ctg      698
 Ser Glu Thr Ser Thr Ile Pro Ala Met Glu Arg Leu Ile Glu Trp Leu
 170                 175                 180                 185

 ccc ctc cat ctt ccc cgt cag cag agg acc aca gtg gtg cac ggg gac      746
 Pro Leu His Leu Pro Arg Gln Gln Arg Thr Thr Val Val His Gly Asp
                 190                 195                 200

 ttc agg ctc gac aac ctg gtg ttt cat cca gaa gag cca gag gtg ctt      794
 Phe Arg Leu Asp Asn Leu Val Phe His Pro Glu Glu Pro Glu Val Leu
             205                 210                 215

 gct gtc ctt gac tgg gaa ctt tct acc ttg ggc gac ccc ctt gct gat      842
 Ala Val Leu Asp Trp Glu Leu Ser Thr Leu Gly Asp Pro Leu Ala Asp
         220                 225                 230

 gtg gcc tac agc tgc ctg gct cat tac ctg cca tcc agt ttt ccc gtg      890
 Val Ala Tyr Ser Cys Leu Ala His Tyr Leu Pro Ser Ser Phe Pro Val
     235                 240                 245

 ctg aga ggt att aat gac tgt gac ttg aca cag ctg gga atc cct gct      938
 Leu Arg Gly Ile Asn Asp Cys Asp Leu Thr Gln Leu Gly Ile Pro Ala
 250                 255                 260                 265

 gca gag gag tat ttc agg atg tac tgt ctc caa atg ggg ctc cct ccc      986
 Ala Glu Glu Tyr Phe Arg Met Tyr Cys Leu Gln Met Gly Leu Pro Pro
                 270                 275                 280

 act gag aac tgg aac ttc tat atg gct ttt tcc ttt ttc cgt gtg gct     1034
 Thr Glu Asn Trp Asn Phe Tyr Met Ala Phe Ser Phe Phe Arg Val Ala
             285                 290                 295

 gca atc cta cag gga gtc tac aag cga tca ctc aca ggg caa gca agc     1082
 Ala Ile Leu Gln Gly Val Tyr Lys Arg Ser Leu Thr Gly Gln Ala Ser
         300                 305                 310

 tcc aca tat gcg gaa caa act gga aag ctg acc gaa ttt gtg tct aac     1130
 Ser Thr Tyr Ala Glu Gln Thr Gly Lys Leu Thr Glu Phe Val Ser Asn
     315                 320                 325

 ctg gcg tgg gat ttc gca gtc aaa gaa ggg ttc cgg gtt ttc aaa gag     1178
 Leu Ala Trp Asp Phe Ala Val Lys Glu Gly Phe Arg Val Phe Lys Glu
 330                 335                 340                 345

 atg ccc ttc aca aat ccg tta aca agg tcc tac cac acg tgg gcc agg     1226
 Met Pro Phe Thr Asn Pro Leu Thr Arg Ser Tyr His Thr Trp Ala Arg
                 350                 355                 360

 ccc cag tcc cag tgg tgc ccc aca ggc agc agg agt tat agc tcc gtt     1274
 Pro Gln Ser Gln Trp Cys Pro Thr Gly Ser Arg Ser Tyr Ser Ser Val
             365                 370                 375

 cca gaa gct tcc cca gct cat acc tca agg gga ggt ctg gtt atc tct     1322
 Pro Glu Ala Ser Pro Ala His Thr Ser Arg Gly Gly Leu Val Ile Ser
         380                 385                 390

 cca gag agc ctc tct cca cct gtc aga gag ctg tat cac cgg ctg aag     1370
 Pro Glu Ser Leu Ser Pro Pro Val Arg Glu Leu Tyr His Arg Leu Lys
     395                 400                 405

 cac ttc atg gag caa cgt gtg tac cct gca gag cca gag ctg cag agt     1418
 His Phe Met Glu Gln Arg Val Tyr Pro Ala Glu Pro Glu Leu Gln Ser
 410                 415                 420                 425

 cac cag gcc tca gca gcc agg tgg agc ccc tcc cca ctg atc gaa gac     1466
 His Gln Ala Ser Ala Ala Arg Trp Ser Pro Ser Pro Leu Ile Glu Asp
                 430                 435                 440

 ctc aag gag aaa gcc aaa gct gaa gga ctt tgg aac ctt ttc cta ccc     1514
 Leu Lys Glu Lys Ala Lys Ala Glu Gly Leu Trp Asn Leu Phe Leu Pro
             445                 450                 455

 tta gag gct gat ccc gag aaa aaa tac gga gca gga ctg acc aat gtg     1562
 Leu Glu Ala Asp Pro Glu Lys Lys Tyr Gly Ala Gly Leu Thr Asn Val
         460                 465                 470

 gaa tat gca cat ctg tgt gag ctc atg ggc acg tcc ctg tat gcc ccc     1610
 Glu Tyr Ala His Leu Cys Glu Leu Met Gly Thr Ser Leu Tyr Ala Pro
     475                 480                 485

 gag gta tgt aac tgc tct gcg cct gac acg ggc aac atg gag ctg ctg     1658
 Glu Val Cys Asn Cys Ser Ala Pro Asp Thr Gly Asn Met Glu Leu Leu
 490                 495                 500                 505

 gtg agg tat ggc acc gaa gcg cag aag gct cgc tgg ctg att cct ctg     1706
 Val Arg Tyr Gly Thr Glu Ala Gln Lys Ala Arg Trp Leu Ile Pro Leu
                 510                 515                 520

 ctg gag ggg aaa gcc cgc tcc tgt ttt gct atg acc gag ccc cag gtt     1754
 Leu Glu Gly Lys Ala Arg Ser Cys Phe Ala Met Thr Glu Pro Gln Val
             525                 530                 535

 gcc tct tca gat gcc acc aac att gag gct tcc atc aga gag gag gac     1802
 Ala Ser Ser Asp Ala Thr Asn Ile Glu Ala Ser Ile Arg Glu Glu Asp
         540                 545                 550

 agc ttc tat gtc ata aac ggt cac aaa tgg tgg atc aca ggc atc ctg     1850
 Ser Phe Tyr Val Ile Asn Gly His Lys Trp Trp Ile Thr Gly Ile Leu
     555                 560                 565

 gat cct cgt tgc caa ctc tgt gtg ttt atg gga aaa aca gac cca cat     1898
 Asp Pro Arg Cys Gln Leu Cys Val Phe Met Gly Lys Thr Asp Pro His
 570                 575                 580                 585

 gca cca aga cac cgg cag cag tct gtg ctc ttg gtt ccc atg gat acc     1946
 Ala Pro Arg His Arg Gln Gln Ser Val Leu Leu Val Pro Met Asp Thr
                 590                 595                 600

 cca ggg ata aaa atc atc cgg cct ctg acg gtg tat gga ctg gaa gat     1994
 Pro Gly Ile Lys Ile Ile Arg Pro Leu Thr Val Tyr Gly Leu Glu Asp
             605                 610                 615

 gca cca ggt ggc cat ggt gaa gtc cga ttt gag cac gtg cgt gtg ccc     2042
 Ala Pro Gly Gly His Gly Glu Val Arg Phe Glu His Val Arg Val Pro
         620                 625                 630

 aaa gag aac atg gtc ctg ggc cct ggc cga ggc ttt gag atc gcc cag     2090
 Lys Glu Asn Met Val Leu Gly Pro Gly Arg Gly Phe Glu Ile Ala Gln
     635                 640                 645

 ggc aga ctg ggc ccc ggc agg atc cat cac tgc atg agg ctg atc ggg     2138
 Gly Arg Leu Gly Pro Gly Arg Ile His His Cys Met Arg Leu Ile Gly
 650                 655                 660                 665

 ttc tca gag agg gcc ctg gca ctc atg aag gcc cgc gtg aag tcc cgc     2186
 Phe Ser Glu Arg Ala Leu Ala Leu Met Lys Ala Arg Val Lys Ser Arg
                 670                 675                 680

 ttg gct ttt ggg aag ccc ctg gtg gag cag ggc aca gtg ctg gcg gac     2234
 Leu Ala Phe Gly Lys Pro Leu Val Glu Gln Gly Thr Val Leu Ala Asp
             685                 690                 695

 atc gca cag tcg cgc gtg gag att gag cag gca cgg ctg ctg gtg ctg     2282
 Ile Ala Gln Ser Arg Val Glu Ile Glu Gln Ala Arg Leu Leu Val Leu
         700                 705                 710

 aga gct gcc cac ctc atg gac ctg gca gga aac aag gct gca gcc ttg     2330
 Arg Ala Ala His Leu Met Asp Leu Ala Gly Asn Lys Ala Ala Ala Leu
     715                 720                 725

 gat ata gcc atg att aaa atg gtc gcc ccg tcc atg gcc tcc cga gtg     2378
 Asp Ile Ala Met Ile Lys Met Val Ala Pro Ser Met Ala Ser Arg Val
 730                 735                 740                 745

 att gat cgt gcg att cag aag acg tct ctg caa gaa gcc tgg agt ctg     2426
 Ile Asp Arg Ala Ile Gln Lys Thr Ser Leu Gln Glu Ala Trp Ser Leu
                 750                 755                 760

 ttt cag gcc agg agg agg gga ttt gct gag ggc caa ggg ggt tct ggg     2474
 Phe Gln Ala Arg Arg Arg Gly Phe Ala Glu Gly Gln Gly Gly Ser Gly
             765                 770                 775

 aca gag tct gga aag ctg gtc ttc agg ctc tca gtc cca ggc tgg gca     2522
 Thr Glu Ser Gly Lys Leu Val Phe Arg Leu Ser Val Pro Gly Trp Ala
         780                 785                 790

 ggc acg gtc act tca ctt cag cct ttc agt ccc tct ctc tct gcc tgt     2570
 Gly Thr Val Thr Ser Leu Gln Pro Phe Ser Pro Ser Leu Ser Ala Cys
     795                 800                 805

 ggg aat ctg gac aca ttt tgg gag gcc tcc caa ggc tgt ggg acg tgc     2618
 Gly Asn Leu Asp Thr Phe Trp Glu Ala Ser Gln Gly Cys Gly Thr Cys
 810                 815                 820                 825

 ttg ctc tgg cag ctg cag ggt tcc tgt ctg gcc tcc ctg gtg agc aga     2666
 Leu Leu Trp Gln Leu Gln Gly Ser Cys Leu Ala Ser Leu Val Ser Arg
                 830                 835                 840

 ggg gcg gcc acg gcg ggc ggt ggc cta gag acc cag gac ctg ggc gcc     2714
 Gly Ala Ala Thr Ala Gly Gly Gly Leu Glu Thr Gln Asp Leu Gly Ala
             845                 850                 855

 tgg gaa aat gga atg caa ccc aca ttg taa a gccactggca tctgattatc     2765
 Trp Glu Asn Gly Met Gln Pro Thr Leu 
         860                 865

 tccatttgaa cacacagcac agaacaatca tttaaatgtt attttggaaa ggggttttgg   2825

 ggacacagaa gaataagtaa acacatctcg gaggcaaaaa aaaaaaaaaa aaaaaag      2882




      <210> 66
      <211> 486
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(486)

      <400> 66
  atg ggt cgc atg cat gct ccc ggg aag ggc ctg tcc cag tcg gct tta      48
  Met Gly Arg Met His Ala Pro Gly Lys Gly Leu Ser Gln Ser Ala Leu
    1               5                  10                  15

 ccc tat cga cgc agc gtc ccc act tgg ttg aag ttg aca tct gac gac       96
 Pro Tyr Arg Arg Ser Val Pro Thr Trp Leu Lys Leu Thr Ser Asp Asp
              20                  25                  30

 gtg aag gag cag att tac aaa ctg gcc aag aag ggc ctt act cct tca      144
 Val Lys Glu Gln Ile Tyr Lys Leu Ala Lys Lys Gly Leu Thr Pro Ser
          35                  40                  45

 cag atc ggt gta atc ctg aga gat tca cat ggt gtt gca caa gta cgt      192
 Gln Ile Gly Val Ile Leu Arg Asp Ser His Gly Val Ala Gln Val Arg
      50                  55                  60

 ttt gtg aca ggc aat aaa att tta aga att ctt aag tct aag gga ctt      240
 Phe Val Thr Gly Asn Lys Ile Leu Arg Ile Leu Lys Ser Lys Gly Leu
  65                  70                  75                  80

 gct cct gat ctt cct gaa gat ctc tac cat tta att aag aaa gca gtt      288
 Ala Pro Asp Leu Pro Glu Asp Leu Tyr His Leu Ile Lys Lys Ala Val
                  85                  90                  95

 gct gtt cga aag cat ctt gag agg aac aga aag gat aag gat gct aaa      336
 Ala Val Arg Lys His Leu Glu Arg Asn Arg Lys Asp Lys Asp Ala Lys
             100                 105                 110

 ttc cgt ctg att cta ata gag agc cgg att cac cgt ttg gct cga tat      384
 Phe Arg Leu Ile Leu Ile Glu Ser Arg Ile His Arg Leu Ala Arg Tyr
         115                 120                 125

 tat aag acc aag cga gtc ctc cct ccc aat tgg aaa tat gaa tca ttt      432
 Tyr Lys Thr Lys Arg Val Leu Pro Pro Asn Trp Lys Tyr Glu Ser Phe
     130                 135                 140

 tat tgc ttg agt aca cag aca aat tta tgc gac cag ggc aga ggc tgt      480
 Tyr Cys Leu Ser Thr Gln Thr Asn Leu Cys Asp Gln Gly Arg Gly Cys
 145                 150                 155                 160

 aga tga                                                              486
 Arg 






      <210> 67
      <211> 618
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (68)..(604)

      <400> 67
 atacatcagc tcggtacccg gatcattttc ttcttccgga cagtagacac cctgcccgtg     60

 cggagag  atg tca tgg ggg cac ctg ctc tcc ctg ata gat gct gag agc     109
          Met Ser Trp Gly His Leu Leu Ser Leu Ile Asp Ala Glu Ser
            1               5                  10

 atc cag aaa ctt cca gac cag ccc tct cac cac acc cag aag agg cct      157
 Ile Gln Lys Leu Pro Asp Gln Pro Ser His His Thr Gln Lys Arg Pro
  15                  20                  25                  30

 ttc cca tct gga gag aag ctt cca gac cag ccc ttc aca cac cac agc      205
 Phe Pro Ser Gly Glu Lys Leu Pro Asp Gln Pro Phe Thr His His Ser
                  35                  40                  45

 cag gag ggg cct ttc cca cct gga gag aaa ctt cca gac cag ccc ctc      253
 Gln Glu Gly Pro Phe Pro Pro Gly Glu Lys Leu Pro Asp Gln Pro Leu
              50                  55                  60

 ata cca cag cca aga ggg gcc ttt ctc acc tgg aga gaa act tcc aga      301
 Ile Pro Gln Pro Arg Gly Ala Phe Leu Thr Trp Arg Glu Thr Ser Arg
          65                  70                  75

 cca gcc cct cac acc acc gcc agg aga ggc ctt tcc cac cgg gag aga      349
 Pro Ala Pro His Thr Thr Ala Arg Arg Gly Leu Ser His Arg Glu Arg
      80                  85                  90

 aac ttc cag acc agc ccc tca cac cac agc cag gat gag gcc ttt ccc      397
 Asn Phe Gln Thr Ser Pro Ser His His Ser Gln Asp Glu Ala Phe Pro
  95                 100                 105                 110

 gcc tgg aga gaa act tcc aga cca gcc ctc tca cta cag cca gaa gag      445
 Ala Trp Arg Glu Thr Ser Arg Pro Ala Leu Ser Leu Gln Pro Glu Glu
                 115                 120                 125

 gcc ttt ccc acc tgg aga gga act tcc aga cca gcc ctt cac aca cca      493
 Ala Phe Pro Thr Trp Arg Gly Thr Ser Arg Pro Ala Leu His Thr Pro
             130                 135                 140

 cag cca gga gag gcc ttt ccc gcc tgg gga gaa gct tcc agg cca gct      541
 Gln Pro Gly Glu Ala Phe Pro Ala Trp Gly Glu Ala Ser Arg Pro Ala
         145                 150                 155

 cct ctc acc aca gcc agg aga ggc ctt ttc tgc ctg gag aga aac tct      589
 Pro Leu Thr Thr Ala Arg Arg Gly Leu Phe Cys Leu Glu Arg Asn Ser
     160                 165                 170

 tca gac cag gcg tag tgtatgctcg gatt                                  618
 Ser Asp Gln Ala 
 175





      <210> 68
      <211> 1551
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (526)..(1551)

      <400> 68
 atggaaaagc tggcctctat cataactcac tcatccctct gtcagtggtt gcaggtgagc     60

 aggccgttgg cacaagagca acatgaccac actctgattg agtggcaatg ggcagccata    120

 cggactgtgt ggaatgacgc tggtgaaata cccaaaactg agagtaaatg gcagtcgtat    180

 gccaatttgg tggaaatcat ccaggagatg ggtatgcagc aggctatgtt ttacctgaat    240

 acctgggggc cagatgatga acatttcacc tcccacatga gggatctcat gcctttggtt    300

 ccctatctgc ggccttcacc ctatatctca aatgataaaa ctgttgcatt ggttaacaaa    360

 gaaggagcca cccaggattg ggataatgca gctgagaaca ccttcctggc agcgaagcag    420

 gctattcagc aggcacaagc cctatgggta gttgatcagg ggtgtccgtt tgagcaggat    480

 gtgcatgtga ctacagatgg tttcggctgg ggcctgtggc agtgt    atg gag tgc     534
                                                      Met Glu Cys
                                                        1

 tta aga atg cca gta ggc ttt tgg tcc caa cta tgg aaa gga gct gag      582
 Leu Arg Met Pro Val Gly Phe Trp Ser Gln Leu Trp Lys Gly Ala Glu
       5                  10                  15

 ctc cgg tat tcc ttg aca gag aaa cag cta gca gct gta tat gcc acc      630
 Leu Arg Tyr Ser Leu Thr Glu Lys Gln Leu Ala Ala Val Tyr Ala Thr
  20                  25                  30                  35

 ctt cag gct cat gac agc atg aca gga tgg gct gca gtc atc ata tgg      678
 Leu Gln Ala His Asp Ser Met Thr Gly Trp Ala Ala Val Ile Ile Trp
                  40                  45                  50

 aca act tac cca ata aca gga tgg atg cgt cta tgt gta atg acc acc      726
 Thr Thr Tyr Pro Ile Thr Gly Trp Met Arg Leu Cys Val Met Thr Thr
              55                  60                  65

 tgg agt ggg ata gca cag atg tcc act ttg gca aaa tgg ggc aac tcc      774
 Trp Ser Gly Ile Ala Gln Met Ser Thr Leu Ala Lys Trp Gly Asn Ser
          70                  75                  80

 ttg cag cag tgg agt aag ctg agt aca agt ccc ata gca gca gag ttg      822
 Leu Gln Gln Trp Ser Lys Leu Ser Thr Ser Pro Ile Ala Ala Glu Leu
      85                  90                  95

 caa gag atc ttg gga cct gta gtc cta atg caa gac aag gcc atg cgg      870
 Gln Glu Ile Leu Gly Pro Val Val Leu Met Gln Asp Lys Ala Met Arg
 100                 105                 110                 115

 cct gag gca ccc cta gat cct gag tct tca cca ttt aag gaa ggg cat      918
 Pro Glu Ala Pro Leu Asp Pro Glu Ser Ser Pro Phe Lys Glu Gly His
                 120                 125                 130

 ccc agg att cct gag ggg gca tgg tac aca gta gat gag gtg cta ctg      966
 Pro Arg Ile Pro Glu Gly Ala Trp Tyr Thr Val Asp Glu Val Leu Leu
             135                 140                 145

 ctg cct gga cca ctg ttg cag tcc aac cta gta ctg aca cca tat ggt     1014
 Leu Pro Gly Pro Leu Leu Gln Ser Asn Leu Val Leu Thr Pro Tyr Gly
         150                 155                 160

 ttg aaa ctg ggc cat atg cct ttg gcc acc cct agt aat gat gag gca     1062
 Leu Lys Leu Gly His Met Pro Leu Ala Thr Pro Ser Asn Asp Glu Ala
     165                 170                 175

 gat gcc ttg gct aag gtc aga tgg tca gag tca gca cca aca caa gat     1110
 Asp Ala Leu Ala Lys Val Arg Trp Ser Glu Ser Ala Pro Thr Gln Asp
 180                 185                 190                 195

 gtg acc ttg tgg cta cac cgg aaa ctg gga cat gca ggg ggt aaa ctg     1158
 Val Thr Leu Trp Leu His Arg Lys Leu Gly His Ala Gly Gly Lys Leu
                 200                 205                 210

 atg caa caa ttc aat aag tgt tgg ggt ctg tcc ctt ccc aag caa gac     1206
 Met Gln Gln Phe Asn Lys Cys Trp Gly Leu Ser Leu Pro Lys Gln Asp
             215                 220                 225

 att tgt gag gct tgt cag aaa tgc ctg gca tgt gtt cag aca tat cct     1254
 Ile Cys Glu Ala Cys Gln Lys Cys Leu Ala Cys Val Gln Thr Tyr Pro
         230                 235                 240

 aaa aag agg cag ctg ccc ggt gtt ata caa caa gta aca ata ggg gtg     1302
 Lys Lys Arg Gln Leu Pro Gly Val Ile Gln Gln Val Thr Ile Gly Val
     245                 250                 255

 gcc aac caa cag aac acc atc cag gcc ctg caa cac tta tgt tcc ctg     1350
 Ala Asn Gln Gln Asn Thr Ile Gln Ala Leu Gln His Leu Cys Ser Leu
 260                 265                 270                 275

 tat ggt tgt cct ctg gcc att gag agt gat agg gga aca cat ttc act     1398
 Tyr Gly Cys Pro Leu Ala Ile Glu Ser Asp Arg Gly Thr His Phe Thr
                 280                 285                 290

 gga caa cag aac cca gac ctg cca aaa acc aac aat att gcc ttc cct     1446
 Gly Gln Gln Asn Pro Asp Leu Pro Lys Thr Asn Asn Ile Ala Phe Pro
             295                 300                 305

 gag ttt tct tta act gaa ctc cta ctg cag aaa gaa aga ctg aag tct     1494
 Glu Phe Ser Leu Thr Glu Leu Leu Leu Gln Lys Glu Arg Leu Lys Ser
         310                 315                 320

 ctc aac aca aca gac ttt tgt cac act gct ctg cag gcc caa cag act     1542
 Leu Asn Thr Thr Asp Phe Cys His Thr Ala Leu Gln Ala Gln Gln Thr
     325                 330                 335

 ttg tcc tag                                                         1551
 Leu Ser 
 340





      <210> 69
      <211> 954
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(954)

      <400> 69
  atg aag gag tca cgc ctc ccg ctc ccg gag ctg ccc agt ggc tgc ctt      48
  Met Lys Glu Ser Arg Leu Pro Leu Pro Glu Leu Pro Ser Gly Cys Leu
    1               5                  10                  15

 gtc ctt caa gtg cag gag ctg gtt caa atg tca gga atg gaa gcc act       96
 Val Leu Gln Val Gln Glu Leu Val Gln Met Ser Gly Met Glu Ala Thr
              20                  25                  30

 gtg acc atc cca atc tgg caa aac aag cca cat ggg gct gct cga agt      144
 Val Thr Ile Pro Ile Trp Gln Asn Lys Pro His Gly Ala Ala Arg Ser
          35                  40                  45

 gta gta aga aga att ggg acc aac cta ccc ttg aag ccg tgt gcc cgg      192
 Val Val Arg Arg Ile Gly Thr Asn Leu Pro Leu Lys Pro Cys Ala Arg
      50                  55                  60

 gcg tcc ttt gag acc ctg ccc aac atc tct gac ctg tgt ttg aga gat      240
 Ala Ser Phe Glu Thr Leu Pro Asn Ile Ser Asp Leu Cys Leu Arg Asp
  65                  70                  75                  80

 gtg ccc cca gtc cct acc ctg gct gac atc gcc tgg att gct gcg gat      288
 Val Pro Pro Val Pro Thr Leu Ala Asp Ile Ala Trp Ile Ala Ala Asp
                  85                  90                  95

 gaa gag gag aca tat gcc cgg gtc agg agt gat acg cgc ccc ctg agg      336
 Glu Glu Glu Thr Tyr Ala Arg Val Arg Ser Asp Thr Arg Pro Leu Arg
             100                 105                 110

 cac acc tgg aaa ccc agc cct ctg att gtc atg cag cgc aat gcc tct      384
 His Thr Trp Lys Pro Ser Pro Leu Ile Val Met Gln Arg Asn Ala Ser
         115                 120                 125

 gtt ccc aac ctg cgt ggg tcc gag gag agg ctt ctg gcc ctg aag aag      432
 Val Pro Asn Leu Arg Gly Ser Glu Glu Arg Leu Leu Ala Leu Lys Lys
     130                 135                 140

 cca gct ctg cca gcc cta agc cgc act act gag ctg cag gac gag ctg      480
 Pro Ala Leu Pro Ala Leu Ser Arg Thr Thr Glu Leu Gln Asp Glu Leu
 145                 150                 155                 160

 agc cac ttg cgc agc cag att gca aag ata gtg gca gct gat gca gct      528
 Ser His Leu Arg Ser Gln Ile Ala Lys Ile Val Ala Ala Asp Ala Ala
                 165                 170                 175

 tcg gct tca tta acg cca gat ttc tta tct cca gga agt tca aat gtc      576
 Ser Ala Ser Leu Thr Pro Asp Phe Leu Ser Pro Gly Ser Ser Asn Val
             180                 185                 190

 tct tct ccc tta cct tgt ttt gga tcc tca ttc cac tct aca act tcc      624
 Ser Ser Pro Leu Pro Cys Phe Gly Ser Ser Phe His Ser Thr Thr Ser
         195                 200                 205

 ttt gtc att agt gac atc acc gag gag aca gag gtg gag gtc cct gag      672
 Phe Val Ile Ser Asp Ile Thr Glu Glu Thr Glu Val Glu Val Pro Glu
     210                 215                 220

 ctt cca tca gtc ccc ctg ctt tgt tct gcc agc cct gaa tgt tgc aaa      720
 Leu Pro Ser Val Pro Leu Leu Cys Ser Ala Ser Pro Glu Cys Cys Lys
 225                 230                 235                 240

 cca gaa cac aaa gct gcc tgc agt tcg tct gaa gag gat gac tgc gtc      768
 Pro Glu His Lys Ala Ala Cys Ser Ser Ser Glu Glu Asp Asp Cys Val
                 245                 250                 255

 tct ttg tcc aag gcc agc agc ttt gca gac atg atg ggt atc ctg aag      816
 Ser Leu Ser Lys Ala Ser Ser Phe Ala Asp Met Met Gly Ile Leu Lys
             260                 265                 270

 gac ttt cac cga atg aaa cag agt caa gat ctg aac cgg agt tta ttg      864
 Asp Phe His Arg Met Lys Gln Ser Gln Asp Leu Asn Arg Ser Leu Leu
         275                 280                 285

 aag gag gaa gac cct gct gtg ctt atc tct gag gtc cta agg agg aag      912
 Lys Glu Glu Asp Pro Ala Val Leu Ile Ser Glu Val Leu Arg Arg Lys
     290                 295                 300

 ttt gct cta aag gaa gaa gat atc agt aga aaa gga aat tga              954
 Phe Ala Leu Lys Glu Glu Asp Ile Ser Arg Lys Gly Asn 
 305                 310                 315





      <210> 70
      <211> 4200
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (92)..(3028)

      <400> 70
 ctcttcccac agttcttctg ggggatcttc acatcatgct aaggaacagc ttccaaagta     60

 ccagtacaca agaccagctt ccgatgtcaa c   atg tta ggg gaa atg atg ttt     112
                                      Met Leu Gly Glu Met Met Phe
                                        1               5

 ggc tca gtt gcc atg agt tac aaa ggc tcc acc tta aag ata cac tac      160
 Gly Ser Val Ala Met Ser Tyr Lys Gly Ser Thr Leu Lys Ile His Tyr
          10                  15                  20

 ata cgt tct cct cca caa ctg atg att agt aaa gtc ttc tct gct aga      208
 Ile Arg Ser Pro Pro Gln Leu Met Ile Ser Lys Val Phe Ser Ala Arg
      25                  30                  35

 atg ggc agc ttc tgt gga agt aca aat aac ttg caa gac agc ttt gag      256
 Met Gly Ser Phe Cys Gly Ser Thr Asn Asn Leu Gln Asp Ser Phe Glu
  40                  45                  50                  55

 tac atc aac caa gat cct aat ttg gga aaa ctg aac aca aat caa aat      304
 Tyr Ile Asn Gln Asp Pro Asn Leu Gly Lys Leu Asn Thr Asn Gln Asn
                  60                  65                  70

 agt ttg ggt cct tgt cgt act gga agt aac cta gca cac agc aca cca      352
 Ser Leu Gly Pro Cys Arg Thr Gly Ser Asn Leu Ala His Ser Thr Pro
              75                  80                  85

 gtt gat atg cca agc aga gga cag aat gaa gac agg gac agt ggc att      400
 Val Asp Met Pro Ser Arg Gly Gln Asn Glu Asp Arg Asp Ser Gly Ile
          90                  95                 100

 gct cga tca gcc tca cta agc agt ctt ttg atc aca cct ttc cca tct      448
 Ala Arg Ser Ala Ser Leu Ser Ser Leu Leu Ile Thr Pro Phe Pro Ser
     105                 110                 115

 cca agc tcc tct aca tct tct tcc agc agt tac cag cgc cgc tgg ctt      496
 Pro Ser Ser Ser Thr Ser Ser Ser Ser Ser Tyr Gln Arg Arg Trp Leu
 120                 125                 130                 135

 cga agt cag aca aca agt ttg gaa aat ggc atc atc cca aga agg tca      544
 Arg Ser Gln Thr Thr Ser Leu Glu Asn Gly Ile Ile Pro Arg Arg Ser
                 140                 145                 150

 act gat gag aca ttc agc ttg gct gaa gaa acc tgt agc tct aat cca      592
 Thr Asp Glu Thr Phe Ser Leu Ala Glu Glu Thr Cys Ser Ser Asn Pro
             155                 160                 165

 gct atg gtt agg agg aag aaa att gcc ata agc atc atc ttt tcc cta      640
 Ala Met Val Arg Arg Lys Lys Ile Ala Ile Ser Ile Ile Phe Ser Leu
         170                 175                 180

 tgt gag aaa gaa gaa gca caa agg aat ttc cag gac ttc ttc ttt tct      688
 Cys Glu Lys Glu Glu Ala Gln Arg Asn Phe Gln Asp Phe Phe Phe Ser
     185                 190                 195

 cat ttt ccc ctg ttt gaa tct cac atg aac agg ctg aag agt gca att      736
 His Phe Pro Leu Phe Glu Ser His Met Asn Arg Leu Lys Ser Ala Ile
 200                 205                 210                 215

 gaa aag gct atg atc tcc tgt agg aaa ata gca gaa tca agt ctc cga      784
 Glu Lys Ala Met Ile Ser Cys Arg Lys Ile Ala Glu Ser Ser Leu Arg
                 220                 225                 230

 gtc cag ttt tat gtc agc cgt ttg atg gaa gct ctg gga gaa ttc aga      832
 Val Gln Phe Tyr Val Ser Arg Leu Met Glu Ala Leu Gly Glu Phe Arg
             235                 240                 245

 gga act atc tgg aac tta tat tct gtt cca agg ata gct gaa cct gta      880
 Gly Thr Ile Trp Asn Leu Tyr Ser Val Pro Arg Ile Ala Glu Pro Val
         250                 255                 260

 tgg ctt act atg atg tcc ggc act ttg gaa aaa aac cag ctc tgc cag      928
 Trp Leu Thr Met Met Ser Gly Thr Leu Glu Lys Asn Gln Leu Cys Gln
     265                 270                 275

 cgc ttt ctc aag gag ttt aca ctt ctg ata gaa cag ata aat aaa aac      976
 Arg Phe Leu Lys Glu Phe Thr Leu Leu Ile Glu Gln Ile Asn Lys Asn
 280                 285                 290                 295

 cag ttt ttt gct gcc tta ctg act gcg gtg tta acc tac cac ctg gcc     1024
 Gln Phe Phe Ala Ala Leu Leu Thr Ala Val Leu Thr Tyr His Leu Ala
                 300                 305                 310

 tgg gtc cca act gtc atg cct gtg gat cac cct ccc atc aaa gcc ttc     1072
 Trp Val Pro Thr Val Met Pro Val Asp His Pro Pro Ile Lys Ala Phe
             315                 320                 325

 tca gag aaa cgt acc tcc cag tca gtg aac atg ctg gcc aaa aca cat     1120
 Ser Glu Lys Arg Thr Ser Gln Ser Val Asn Met Leu Ala Lys Thr His
         330                 335                 340

 ccg tat aat cct ctt tgg gca cag ctg ggt gat ctt tac gga gcc ata     1168
 Pro Tyr Asn Pro Leu Trp Ala Gln Leu Gly Asp Leu Tyr Gly Ala Ile
     345                 350                 355

 ggc tct cca gtg aga ctg act cgc acc gta gtg gta ggg aag cag aag     1216
 Gly Ser Pro Val Arg Leu Thr Arg Thr Val Val Val Gly Lys Gln Lys
 360                 365                 370                 375

 gac tta gtc cag cga ata ctt tat gtc ctg acc tac ttt ctc cgt tgc     1264
 Asp Leu Val Gln Arg Ile Leu Tyr Val Leu Thr Tyr Phe Leu Arg Cys
                 380                 385                 390

 tct gag cta caa gag aac cag ctg acc tgg agt ggc aat cat ggt gaa     1312
 Ser Glu Leu Gln Glu Asn Gln Leu Thr Trp Ser Gly Asn His Gly Glu
             395                 400                 405

 ggt gac caa gtt tta aat ggg agc aag atc ata aca gcc ttg gag aaa     1360
 Gly Asp Gln Val Leu Asn Gly Ser Lys Ile Ile Thr Ala Leu Glu Lys
         410                 415                 420

 gga gag gtg gag gag tct gag tat gtg gtc att acg gtg agg aac gag     1408
 Gly Glu Val Glu Glu Ser Glu Tyr Val Val Ile Thr Val Arg Asn Glu
     425                 430                 435

 ccc gct ctt gta ccc ccc atc cta cca cca aca gca gca gag aga cac     1456
 Pro Ala Leu Val Pro Pro Ile Leu Pro Pro Thr Ala Ala Glu Arg His
 440                 445                 450                 455

 aac ccc tgg ccg aca ggg ttt cct gag tgc cca gag ggc act gac agt     1504
 Asn Pro Trp Pro Thr Gly Phe Pro Glu Cys Pro Glu Gly Thr Asp Ser
                 460                 465                 470

 aga gac ctg ggt ctt aaa cct gac aaa gaa gct aac agg agg cca gag     1552
 Arg Asp Leu Gly Leu Lys Pro Asp Lys Glu Ala Asn Arg Arg Pro Glu
             475                 480                 485

 cag ggt tct gag gct tgc agc gca ggg tgc ctg ggg cca gca tca gac     1600
 Gln Gly Ser Glu Ala Cys Ser Ala Gly Cys Leu Gly Pro Ala Ser Asp
         490                 495                 500

 gct tcc tgg aaa cct cag aat gca ttt tgt ggg gat gag aaa aat aaa     1648
 Ala Ser Trp Lys Pro Gln Asn Ala Phe Cys Gly Asp Glu Lys Asn Lys
     505                 510                 515

 gag gca ccg caa gat ggc tct tca aga ctt ccc agc tgt gaa gtt ttg     1696
 Glu Ala Pro Gln Asp Gly Ser Ser Arg Leu Pro Ser Cys Glu Val Leu
 520                 525                 530                 535

 ggg gca gga atg aag atg gac cag caa gct gtc tgt gag ctg ttg aaa     1744
 Gly Ala Gly Met Lys Met Asp Gln Gln Ala Val Cys Glu Leu Leu Lys
                 540                 545                 550

 gtg gag atg cct aca aga ctg cca gac cgg tca gtg gcc tgg cct tgc     1792
 Val Glu Met Pro Thr Arg Leu Pro Asp Arg Ser Val Ala Trp Pro Cys
             555                 560                 565

 cct gac aga cat ctc cgg gag aaa cct tcc tta gaa aag gtc act ttc     1840
 Pro Asp Arg His Leu Arg Glu Lys Pro Ser Leu Glu Lys Val Thr Phe
         570                 575                 580

 cag att gga agc ttt gca tct cca gag tct gac ttt gaa agc cgc atg     1888
 Gln Ile Gly Ser Phe Ala Ser Pro Glu Ser Asp Phe Glu Ser Arg Met
     585                 590                 595

 aaa aaa atg gag gaa cgg gtg aag gcc tgt ggc ccc tcc ttg gag gcc     1936
 Lys Lys Met Glu Glu Arg Val Lys Ala Cys Gly Pro Ser Leu Glu Ala
 600                 605                 610                 615

 agt gag gct gct gat gtg gct cag gac ccg cag gtt tct agg agc cct     1984
 Ser Glu Ala Ala Asp Val Ala Gln Asp Pro Gln Val Ser Arg Ser Pro
                 620                 625                 630

 ttt aaa cct ggc ttt cag gag aat gtt tgc tgt cct cag aat cgg ctt     2032
 Phe Lys Pro Gly Phe Gln Glu Asn Val Cys Cys Pro Gln Asn Arg Leu
             635                 640                 645

 tca gag ggg gat gaa ggc gag tct gac aag ggt ttt gca gag gac aga     2080
 Ser Glu Gly Asp Glu Gly Glu Ser Asp Lys Gly Phe Ala Glu Asp Arg
         650                 655                 660

 ggc agc aga aac gac atg gca gca gat att gct ggg cag ctc agc cac     2128
 Gly Ser Arg Asn Asp Met Ala Ala Asp Ile Ala Gly Gln Leu Ser His
     665                 670                 675

 gct gct gac ttg ggc aca gcc tcc cac ggt gca gga gga acg gga ggg     2176
 Ala Ala Asp Leu Gly Thr Ala Ser His Gly Ala Gly Gly Thr Gly Gly
 680                 685                 690                 695

 agg agg ctg gag gcc act aga ggt ttg tat gtg aag gct gcg gaa gga     2224
 Arg Arg Leu Glu Ala Thr Arg Gly Leu Tyr Val Lys Ala Ala Glu Gly
                 700                 705                 710

 cct gtg ctg gag cct gtt gcc ccc agg tgt gtc cag cgg ggc cct ggc     2272
 Pro Val Leu Glu Pro Val Ala Pro Arg Cys Val Gln Arg Gly Pro Gly
             715                 720                 725

 ctc gtg gct ggt gcg aat atc ccc tgt ggg gat gac aac aag aag gcc     2320
 Leu Val Ala Gly Ala Asn Ile Pro Cys Gly Asp Asp Asn Lys Lys Ala
         730                 735                 740

 aac ttc agg act gaa gga gac att ccc cga aat gaa agc tca gat agc     2368
 Asn Phe Arg Thr Glu Gly Asp Ile Pro Arg Asn Glu Ser Ser Asp Ser
     745                 750                 755

 gcc ctg gga gac agt gac gac gaa gcc tgc gct tca gcc atg cta gat     2416
 Ala Leu Gly Asp Ser Asp Asp Glu Ala Cys Ala Ser Ala Met Leu Asp
 760                 765                 770                 775

 ctg ggt cac ggt ggt gac agg act gga ggg tcc ttg gaa gtg gag ctg     2464
 Leu Gly His Gly Gly Asp Arg Thr Gly Gly Ser Leu Glu Val Glu Leu
                 780                 785                 790

 cct ctg cca agg tct cag agc atc agc acc cag aat gta agg aac ttt     2512
 Pro Leu Pro Arg Ser Gln Ser Ile Ser Thr Gln Asn Val Arg Asn Phe
             795                 800                 805

 ggc cgc tca ctt ctg gcg ggc tac tgc ccc aca tac atg cct gat ctt     2560
 Gly Arg Ser Leu Leu Ala Gly Tyr Cys Pro Thr Tyr Met Pro Asp Leu
         810                 815                 820

 gtg ctt cat ggg acc ggc agt gat gag aag ctg aag cag tgc ctg gtg     2608
 Val Leu His Gly Thr Gly Ser Asp Glu Lys Leu Lys Gln Cys Leu Val
     825                 830                 835

 gcc gac ctt gtc cac aca gtc cat cat cca gtc ctg gat gag cca ata     2656
 Ala Asp Leu Val His Thr Val His His Pro Val Leu Asp Glu Pro Ile
 840                 845                 850                 855

 gct gaa gct gtc tgt att atc gca gac acg gat aaa tgg agt gtg cag     2704
 Ala Glu Ala Val Cys Ile Ile Ala Asp Thr Asp Lys Trp Ser Val Gln
                 860                 865                 870

 gta gct aca agt cag agg aaa gtg acg gac aac atg aaa cta ggc cag     2752
 Val Ala Thr Ser Gln Arg Lys Val Thr Asp Asn Met Lys Leu Gly Gln
             875                 880                 885

 gat gtc ctg gtc tct agt cag gtg tcc agt ttg ctt cag tcc att tta     2800
 Asp Val Leu Val Ser Ser Gln Val Ser Ser Leu Leu Gln Ser Ile Leu
         890                 895                 900

 cag ctc tat aag ctt cac ctc cct gct gat ttt tgc atc atg cat ctt     2848
 Gln Leu Tyr Lys Leu His Leu Pro Ala Asp Phe Cys Ile Met His Leu
     905                 910                 915

 gaa gat aga cta cag gag atg tac ctt aaa agt aaa atg cta tct gaa     2896
 Glu Asp Arg Leu Gln Glu Met Tyr Leu Lys Ser Lys Met Leu Ser Glu
 920                 925                 930                 935

 tat ctc cgg gga cac aca cga gtc cat gtg aaa gaa tta ggt gtc gta     2944
 Tyr Leu Arg Gly His Thr Arg Val His Val Lys Glu Leu Gly Val Val
                 940                 945                 950

 ctg ggg att gaa tcc aac gac ctg cct ctg ttg act gct att gcc agt     2992
 Leu Gly Ile Glu Ser Asn Asp Leu Pro Leu Leu Thr Ala Ile Ala Ser
             955                 960                 965

 act cat tct cct tat gtg gct caa ata ctc tta taa gcta aagctcagga     3042
 Thr His Ser Pro Tyr Val Ala Gln Ile Leu Leu 
         970                 975

 cagttcttcc ttggaagaaa aaaatcaaat tctcaactga aggagaaagg aataagctct   3102

 ctgtgatgtc aaaagcatga gaagagcaaa cagaaacagt cattccacct ttttgttttg   3162

 tgtttttgct gtcaagctga tgcttcattg aagacttagg tttacttgac ataatagcat   3222

 ttgtgattgt cgtgaacact ttaggccatt tgttacccat gaatcaacaa agaaactgac   3282

 ctttttggta ggaggaaaca taagcactaa acactaagct gttgcaacag attgccttgt   3342

 gctgtttggg cagaataaag acaagtgact tgagcggggt ggtcagcagt gtacataata   3402

 ttccagtagg aaactgcttc caagtttaag catgagctcc ccaaactgga gaaaacatat   3462

 tttgctattc tgagacaaca atcagaatac agactttgga ttccaggtca cagtttgctt   3522

 tttagacaag gtaaagcaaa gaaagccaca ttgtgccatc ttcagctcca gtggctttag   3582

 cagtgactgt ttgacataaa acatgtaaga attgcttgtt gggaagagtg ctttagggac   3642

 ccactgtttt catttcttct tggagtttac cttgtttcag atgcagccat gggtaggtca   3702

 gagatggatt gttggtgcaa taaacccaag aatcaatgta gcctcttaat cccatcaaga   3762

 tgtagtttgt agcagcaaag tgtacagtct gaaaccgtat gttttatcct tatattttag   3822

 agctttcagc agccttttta agagaggcca cttaccaaag ttatttctat aagctcaaga   3882

 gtgtttcggt tggtaagttc ttccagctga agccactttt tccttatagt taatacaaat   3942

 gactattttt actttaaaag gcacagctgt cctggtggga aatgaaacct gcagcagttc   4002

 aggatgacta atgaaagcaa ttagcttgaa catttagaaa aaattcatat atgatctaaa   4062

 tttttatatt atcatttctg tgccttctaa ttcctgcatc ctgttcaaaa catctttcca   4122

 gacattaact tacacattgt ataaaaccga ccaaaatgat ttcctaaagt tcatgcaaaa   4182

 aaaaaaaaaa aaaaaaga                                                 4200




      <210> 71
      <211> 746
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(746)

      <400> 71
 gcgatccaac gtgccacttg tggataccac gtgccacttg tggatac  atg gag aat      56
                                                      Met Glu Asn
                                                        1

 ccc ttg cca gac acg gtc ctg cgc gtg gac act cgg aga atc cgt tct      104
 Pro Leu Pro Asp Thr Val Leu Arg Val Asp Thr Arg Arg Ile Arg Ser
       5                  10                  15

 cgc cac aca ctt ccc acc atg gac aac tgg aga atc ctt ctc gcc aca      152
 Arg His Thr Leu Pro Thr Met Asp Asn Trp Arg Ile Leu Leu Ala Thr
  20                  25                  30                  35

 cac gtc ctg ccg tgg aca ctg gag atc ctt cta ctc aca cac gtc ccg      200
 His Val Leu Pro Trp Thr Leu Glu Ile Leu Leu Leu Thr His Val Pro
                  40                  45                  50

 ccg tgg ata ctg gag aat cct tct tgc cac aca cgt ccc gcc gtg gac      248
 Pro Trp Ile Leu Glu Asn Pro Ser Cys His Thr Arg Pro Ala Val Asp
              55                  60                  65

 act gga gaa tcc ttc tcg cca cac act tcc cac cgt gga cac tgg aga      296
 Thr Gly Glu Ser Phe Ser Pro His Thr Ser His Arg Gly His Trp Arg
          70                  75                  80

 atc ctt ctc gcc aca cac atc ctg ccg tgg aca ctg gag aat cct tct      344
 Ile Leu Leu Ala Thr His Ile Leu Pro Trp Thr Leu Glu Asn Pro Ser
      85                  90                  95

 act cac aca cgt ccc gct gtg gat act gga gaa tcc ttc tcg ccg cac      392
 Thr His Thr Arg Pro Ala Val Asp Thr Gly Glu Ser Phe Ser Pro His
 100                 105                 110                 115

 acg tcc tgc cat gga cac cgg aga atc cat ctc cac aca tgt ccc gcc      440
 Thr Ser Cys His Gly His Arg Arg Ile His Leu His Thr Cys Pro Ala
                 120                 125                 130

 gtg gac act gga gaa tcc ttt ttg cca cac acg tcc agc cgt gga cac      488
 Val Asp Thr Gly Glu Ser Phe Leu Pro His Thr Ser Ser Arg Gly His
             135                 140                 145

 tgg aga atc cat ctc cac aca cgt atc ctg ctg tgg aca ctg gag aat      536
 Trp Arg Ile His Leu His Thr Arg Ile Leu Leu Trp Thr Leu Glu Asn
         150                 155                 160

 cct tct gcc cac aca cgt cct gct gtg aaa acc tcc acg ctc cct ttc      584
 Pro Ser Ala His Thr Arg Pro Ala Val Lys Thr Ser Thr Leu Pro Phe
     165                 170                 175

 cgt ttt tgc tct cag ctg tcc ttc cag tat gct gct tgg gtc aag cag      632
 Arg Phe Cys Ser Gln Leu Ser Phe Gln Tyr Ala Ala Trp Val Lys Gln
 180                 185                 190                 195

 ccg cat ctc cac tgt cct aat gac aaa aga cac cag cac tgt ctc act      680
 Pro His Leu His Cys Pro Asn Asp Lys Arg His Gln His Cys Leu Thr
                 200                 205                 210

 tcc ttt cct cct cct ctc cag agt gtt acc ttc ctg att gac agg gac      728
 Ser Phe Pro Pro Pro Leu Gln Ser Val Thr Phe Leu Ile Asp Arg Asp
             215                 220                 225

 ttt cgg ttt tct att tag                                              746
 Phe Arg Phe Ser Ile 
         230





      <210> 72
      <211> 638
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (42)..(584)

      <220>
      <221> misc_feature
      <222> (1)...(638)
      <223> n = a,t,c or g

      <400> 72
 gccgttggtg attacggaag aaccaggagt ttggcgtgac c    atg ggg aag cac      53
                                                  Met Gly Lys His
                                                    1

 aag aga aca cgg aag tat gcg acc atg aag cga atg ctt agt ctc aga      101
 Lys Arg Thr Arg Lys Tyr Ala Thr Met Lys Arg Met Leu Ser Leu Arg
   5                  10                  15                  20

 gat cag agg ctt aaa gaa aag gat aga tta aaa cct aaa aag aaa gaa      149
 Asp Gln Arg Leu Lys Glu Lys Asp Arg Leu Lys Pro Lys Lys Lys Glu
                  25                  30                  35

 aag aag gat ccc agc gca tta aag gaa aga gaa gtt ccc caa cac cct      197
 Lys Lys Asp Pro Ser Ala Leu Lys Glu Arg Glu Val Pro Gln His Pro
              40                  45                  50

 tcc tgc tta ttt ttc caa tat aat aca cag ctg ggc cca cct tac cac      245
 Ser Cys Leu Phe Phe Gln Tyr Asn Thr Gln Leu Gly Pro Pro Tyr His
          55                  60                  65

 atc ctc gtt gat acc aac ttt atc aac ttt tcc ata aaa gcc aaa ctg      293
 Ile Leu Val Asp Thr Asn Phe Ile Asn Phe Ser Ile Lys Ala Lys Leu
      70                  75                  80

 gac tta gtg cag tca atg atg gac tgt ctg tat gcc aag tgt atc cca      341
 Asp Leu Val Gln Ser Met Met Asp Cys Leu Tyr Ala Lys Cys Ile Pro
  85                  90                  95                 100

 tgt ata acc gat tgt gta atg gct gaa att gag aaa ttg ggg cac aag      389
 Cys Ile Thr Asp Cys Val Met Ala Glu Ile Glu Lys Leu Gly His Lys
                 105                 110                 115

 tat cga gtg gct cta agg att gcc aag gat cca aga ttt gaa cga tta      437
 Tyr Arg Val Ala Leu Arg Ile Ala Lys Asp Pro Arg Phe Glu Arg Leu
             120                 125                 130

 cca tgt aca cac aaa gga acc tat gca gat gac tgc tta gta cag aga      485
 Pro Cys Thr His Lys Gly Thr Tyr Ala Asp Asp Cys Leu Val Gln Arg
         135                 140                 145

 gtg act cag cat aag tgt tac att gtg gcc aca gtt gac cgg gac ctg      533
 Val Thr Gln His Lys Cys Tyr Ile Val Ala Thr Val Asp Arg Asp Leu
     150                 155                 160

 aga tac aac att gaa cgg atg cca cat gat tat gga gcc cct cga ttc      581
 Arg Tyr Asn Ile Glu Arg Met Pro His Asp Tyr Gly Ala Pro Arg Phe
 165                 170                 175                 180

 taa ttct tacaagacac agttcctctg cctttcttcg accaactttc tcttgttgcn      638
 






      <210> 73
      <211> 565
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (127)..(417)

      <400> 73
 ttggaccgcc cttcgagtgg ctgatgtata taactatcta ttcgatgatg aagatacccc     60

 acgaaaccca aaaaaagaga tctctcgagg atccgaattc gcggccgcgt cgacctcatc    120

 tccaat   atg cct ggt ccg acc gcc agt ggc act aac gtg gga tcc tca     168
          Met Pro Gly Pro Thr Ala Ser Gly Thr Asn Val Gly Ser Ser
            1               5                  10

 ggg cgc tct ccc agc aaa gca gtg gcc gcc cgg gcg gcg gga tcc act      216
 Gly Arg Ser Pro Ser Lys Ala Val Ala Ala Arg Ala Ala Gly Ser Thr
  15                  20                  25                  30

 gtc cgg cat agg aaa aat gcc agc tgt ggg aca agg agt gca ggc cgc      264
 Val Arg His Arg Lys Asn Ala Ser Cys Gly Thr Arg Ser Ala Gly Arg
                  35                  40                  45

 aca acc tcg gca ggc acc ggg ggg atg tgg cga ttc tac aca gaa gat      312
 Thr Thr Ser Ala Gly Thr Gly Gly Met Trp Arg Phe Tyr Thr Glu Asp
              50                  55                  60

 tca cct ggg ctc aaa gat ggc cct gtt cca gga ttg gat atg agg ctt      360
 Ser Pro Gly Leu Lys Asp Gly Pro Val Pro Gly Leu Asp Met Arg Leu
          65                  70                  75

 ctg ttc atc gct tct gta ttt atg ttg cac att tgg ggc aag tac act      408
 Leu Phe Ile Ala Ser Val Phe Met Leu His Ile Trp Gly Lys Tyr Thr
      80                  85                  90

 cgt tcg tag attcagt tacatccatc tgtcatctga agaaggagaa aacaacccaa      464
 Arg Ser 
  95

 catttcttgg accaaaagta tagtgactat ctgttcatga gagaaatttt ctgtaagctt    524

 gctgttttac aggggattta tcaataattg attttgagga a                        565




      <210> 74
      <211> 675
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(675)

      <400> 74
  atg gcc tcc gct atg aag gcg gtg aca gag ctg aat gaa cct ctc tcc      48
  Met Ala Ser Ala Met Lys Ala Val Thr Glu Leu Asn Glu Pro Leu Ser
    1               5                  10                  15

 aat gaa gat cga aat ctc ctc tct gtg gcc tac aag aat gtg gtt ggt       96
 Asn Glu Asp Arg Asn Leu Leu Ser Val Ala Tyr Lys Asn Val Val Gly
              20                  25                  30

 gcc agg cga tct tcc tgg agg gtc att agc agc att gag cag aaa acc      144
 Ala Arg Arg Ser Ser Trp Arg Val Ile Ser Ser Ile Glu Gln Lys Thr
          35                  40                  45

 atg gct gat gga aac gaa aag aaa ttg gag aaa gtt aaa gct tac cgg      192
 Met Ala Asp Gly Asn Glu Lys Lys Leu Glu Lys Val Lys Ala Tyr Arg
      50                  55                  60

 gag aag att gag aag gag ctg gag aca gtt tgc aat gat gtc ctg tct      240
 Glu Lys Ile Glu Lys Glu Leu Glu Thr Val Cys Asn Asp Val Leu Ser
  65                  70                  75                  80

 ctg ctt gac aag ttc ctg atc aag aac tgc aat gat ttc cag tat gag      288
 Leu Leu Asp Lys Phe Leu Ile Lys Asn Cys Asn Asp Phe Gln Tyr Glu
                  85                  90                  95

 agc aag gtg ttt tac ctg aaa atg aag ggt gat tac tac cgc tac tta      336
 Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr Arg Tyr Leu
             100                 105                 110

 gca gag gtc gct tct ggg gag aag aaa aac agt gtg gtc gaa gct tct      384
 Ala Glu Val Ala Ser Gly Glu Lys Lys Asn Ser Val Val Glu Ala Ser
         115                 120                 125

 gaa gct gcc tac aag gaa gcc ttt gaa atc agc aaa gag cag atg caa      432
 Glu Ala Ala Tyr Lys Glu Ala Phe Glu Ile Ser Lys Glu Gln Met Gln
     130                 135                 140

 ccc acg cat ccc atc cgg ctg ggc ctg gcc ctc aac ttc tcc gtg ttc      480
 Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val Phe
 145                 150                 155                 160

 tac tat gag atc cag aat gca cct gca cga acc ccc ctt cta gac caa      528
 Tyr Tyr Glu Ile Gln Asn Ala Pro Ala Arg Thr Pro Leu Leu Asp Gln
                 165                 170                 175

 aaa gcc ctc ggc ttt cga aga gct gag ctg gac aca cta aac gag gat      576
 Lys Ala Leu Gly Phe Arg Arg Ala Glu Leu Asp Thr Leu Asn Glu Asp
             180                 185                 190

 tcc tat aag gac tcc acg ctg atc atg cag ttg ctg cga gac aac ctc      624
 Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn Leu
         195                 200                 205

 acc ctc tgg acg agc gac cag cag gat gaa gaa gca gga gaa ggc aac      672
 Thr Leu Trp Thr Ser Asp Gln Gln Asp Glu Glu Ala Gly Glu Gly Asn
     210                 215                 220

 tga                                                                  675
 






      <210> 75
      <211> 1551
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (370)..(1062)

      <400> 75
 ggtttgcaca gatctgtttg tacctctggg ccatattgca gaaccctgcc cttctttgtt     60

 gactgaggaa agctcgctcc ctgcccaggt ttttcattgt tgatcgaaat taacaccagg    120

 tggtgaatag agcccctcct aaggttgctc aggataaatc atttattaaa taggtctgct    180

 tatcaggagg ggcgtgaagg ctcccaaaag gaaatgctgg cacctgggcc cagaagccag    240

 ggcctctaac tcctggggtt gatttcttca gtgaagttgc accctacaaa gggaatatgg    300

 ccaaagcggc actcaactga aggctgatat caggcgatta gacagccatg cattctgcgt    360

 ttgtctgga    atg gat tgt aga gag atg gac tta tat gag gac tac cag     408
              Met Asp Cys Arg Glu Met Asp Leu Tyr Glu Asp Tyr Gln
                1               5                  10

 tcc ccg ttt gat ttt gat gca gga gtg aac aaa agc tat ctc tac ttg      456
 Ser Pro Phe Asp Phe Asp Ala Gly Val Asn Lys Ser Tyr Leu Tyr Leu
      15                  20                  25

 tct cct agt gga aat tca tct cca ccc gga tca cct act ctt cag aaa      504
 Ser Pro Ser Gly Asn Ser Ser Pro Pro Gly Ser Pro Thr Leu Gln Lys
  30                  35                  40                  45

 ttt ggt ctg ctg aga aca gac cca gtc cct gag gaa gga gaa gat gtt      552
 Phe Gly Leu Leu Arg Thr Asp Pro Val Pro Glu Glu Gly Glu Asp Val
                  50                  55                  60

 gct gcc acg atc agt gcc aca gag acc ctc tcg gaa gag gag cag gaa      600
 Ala Ala Thr Ile Ser Ala Thr Glu Thr Leu Ser Glu Glu Glu Gln Glu
              65                  70                  75

 gag cta aga aga gaa ctt gca aag gta gaa gaa gaa atc cag act ctg      648
 Glu Leu Arg Arg Glu Leu Ala Lys Val Glu Glu Glu Ile Gln Thr Leu
          80                  85                  90

 tct caa gtg tta gca gca aaa gag aag cat cta gca gag atc aag cgg      696
 Ser Gln Val Leu Ala Ala Lys Glu Lys His Leu Ala Glu Ile Lys Arg
      95                 100                 105

 aaa ctt gga atc aat tct cta cag gaa cta aaa cag aac att gcc aaa      744
 Lys Leu Gly Ile Asn Ser Leu Gln Glu Leu Lys Gln Asn Ile Ala Lys
 110                 115                 120                 125

 ggg tgg caa gac gtg aca gca aca tct gct tac aag aag aca tct gaa      792
 Gly Trp Gln Asp Val Thr Ala Thr Ser Ala Tyr Lys Lys Thr Ser Glu
                 130                 135                 140

 acc tta tcc cag gct gga cag aag gcc tca gct gct ttt tcg tct gtt      840
 Thr Leu Ser Gln Ala Gly Gln Lys Ala Ser Ala Ala Phe Ser Ser Val
             145                 150                 155

 ggc tca gtc atc acc aaa aag ctg gaa gat gta aaa aac tcc cca act      888
 Gly Ser Val Ile Thr Lys Lys Leu Glu Asp Val Lys Asn Ser Pro Thr
         160                 165                 170

 ttt aaa tca ttt gaa gaa aag gtc gaa aac tta aag tct aaa gta ggg      936
 Phe Lys Ser Phe Glu Glu Lys Val Glu Asn Leu Lys Ser Lys Val Gly
     175                 180                 185

 gga acc aag cct gct ggt ggt gat ttt gga gaa gtc ttg aat tcg gct      984
 Gly Thr Lys Pro Ala Gly Gly Asp Phe Gly Glu Val Leu Asn Ser Ala
 190                 195                 200                 205

 gca aat gct agt gcc acc acc acg gag cct ctt cca gaa aag aca cag     1032
 Ala Asn Ala Ser Ala Thr Thr Thr Glu Pro Leu Pro Glu Lys Thr Gln
                 210                 215                 220

 gag agc ctg ccc acc ctt cct cca ttc tga g cacataaaaa ccccacactc     1083
 Glu Ser Leu Pro Thr Leu Pro Pro Phe 
             225                 230

 agccagactc aacactcatc aggacaacct gcctgcagaa aggaccactt tgggtctcct   1143

 gagtgctgtt ctgtcattca ataacgctcc tctctgcctt gctcacccta cggttgtcca   1203

 tgtgacttca ttcttcctgg acacaggaca agaactcagg acctgctgaa cagcgggagc   1263

 aaaaggaact gtaacatgtt cctggctggc ttgccaagct ggggcggtga cacgctccca   1323

 gactgcagga gagaagagtg gtgacccttc tggggaccca gacctttggg gattccctga   1383

 gccagagctg ctataacatt tataggcttc cacctttcac cgggcacaga aagtgcccca   1443

 catgacagga ggcagcagca gaagcagggc cagctgagga gccatgggct ggatggggtt   1503

 ggtgggctgt gaacaactgt cccaacggga acaaaacccc tcccccca                1551




      <210> 76
      <211> 516
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(516)

      <400> 76
  atg gag gag cgc ggc gat tcc gag ccg acc ccc ggc tgc agc ggc ctg      48
  Met Glu Glu Arg Gly Asp Ser Glu Pro Thr Pro Gly Cys Ser Gly Leu
    1               5                  10                  15

 ggt ccg ggc ggt gtt cgc ggc ttt ggc gac ggc ggt gga gct cct tcg       96
 Gly Pro Gly Gly Val Arg Gly Phe Gly Asp Gly Gly Gly Ala Pro Ser
              20                  25                  30

 tgg gcc cct gag gac gcc tgg atg ggc act cac cct aag tat cta gaa      144
 Trp Ala Pro Glu Asp Ala Trp Met Gly Thr His Pro Lys Tyr Leu Glu
          35                  40                  45

 atg atg gaa tta gat ata gga gat gcc acc caa gtt tat gta gcg ttc      192
 Met Met Glu Leu Asp Ile Gly Asp Ala Thr Gln Val Tyr Val Ala Phe
      50                  55                  60

 ttg gtt tac ctg gac ctc atg gaa agc aaa agc tgg cat gaa gta aac      240
 Leu Val Tyr Leu Asp Leu Met Glu Ser Lys Ser Trp His Glu Val Asn
  65                  70                  75                  80

 tgt gta gga tta cca gaa ctc cag ctc atc tgc ctt gtt ggt act gag      288
 Cys Val Gly Leu Pro Glu Leu Gln Leu Ile Cys Leu Val Gly Thr Glu
                  85                  90                  95

 ata gaa ggg gag ggg tta cag act gtg gtg cct acc ccc atc act gct      336
 Ile Glu Gly Glu Gly Leu Gln Thr Val Val Pro Thr Pro Ile Thr Ala
             100                 105                 110

 tcc ctc agc cat aac agg ata agg gag atc ttg aag gca tct cga aag      384
 Ser Leu Ser His Asn Arg Ile Arg Glu Ile Leu Lys Ala Ser Arg Lys
         115                 120                 125

 ttg caa ggt gat cca gat ttg ccg atg tct ttt act ttg gcc ata gtg      432
 Leu Gln Gly Asp Pro Asp Leu Pro Met Ser Phe Thr Leu Ala Ile Val
     130                 135                 140

 gag tct gat tct aca ata gtc tat tat aaa ctt act gat gga ttt atg      480
 Glu Ser Asp Ser Thr Ile Val Tyr Tyr Lys Leu Thr Asp Gly Phe Met
 145                 150                 155                 160

 ctg cca gac cct cag aat att tct ctt aga aga tga                      516
 Leu Pro Asp Pro Gln Asn Ile Ser Leu Arg Arg 
                 165                 170





      <210> 77
      <211> 778
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (17)..(724)

      <400> 77
 acgagcagta taggga    atg cgt cac tcg agg caa gac tcc ggc acg ccg      49
                      Met Arg His Ser Arg Gln Asp Ser Gly Thr Pro
                        1               5                  10

 cgc cag gtg gat cgg gtg gtc ggc tcc ctg ggc atg gca cag gat gtg       97
 Arg Gln Val Asp Arg Val Val Gly Ser Leu Gly Met Ala Gln Asp Val
              15                  20                  25

 aga gcc cac cag acc tcc acc ccc aat gcc gag cat ggc agg gcc ccg      145
 Arg Ala His Gln Thr Ser Thr Pro Asn Ala Glu His Gly Arg Ala Pro
          30                  35                  40

 acg gct ggg gct tct ccc gcc cca tgt gtc tgc cca tcc ctc cca cag      193
 Thr Ala Gly Ala Ser Pro Ala Pro Cys Val Cys Pro Ser Leu Pro Gln
      45                  50                  55

 gta gac ccc tac cta ccc tac gag tac acc tgc gag ggg atg ctg gag      241
 Val Asp Pro Tyr Leu Pro Tyr Glu Tyr Thr Cys Glu Gly Met Leu Glu
  60                  65                  70                  75

 cgg atc cac gcc tac atc cag cac cag gac ttc tgc aga gct cca gac      289
 Arg Ile His Ala Tyr Ile Gln His Gln Asp Phe Cys Arg Ala Pro Asp
                  80                  85                  90

 cct gcc cta cca gag gcc cac gcc ccg cag agc ccc ttt gtc ctg gcc      337
 Pro Ala Leu Pro Glu Ala His Ala Pro Gln Ser Pro Phe Val Leu Ala
              95                 100                 105

 ccc aat gcc acc cac ctc gag tgg gct cgg aac acc agc ttg gct cct      385
 Pro Asn Ala Thr His Leu Glu Trp Ala Arg Asn Thr Ser Leu Ala Pro
         110                 115                 120

 ggg gcc tgg ccc ccc gcg cac gcc ctg cgg gcc tgg ctg gcc gtg cct      433
 Gly Ala Trp Pro Pro Ala His Ala Leu Arg Ala Trp Leu Ala Val Pro
     125                 130                 135

 ggg agg gcc tgc acc gac acc tgc ctg gac cac ggg cta atc tgt gag      481
 Gly Arg Ala Cys Thr Asp Thr Cys Leu Asp His Gly Leu Ile Cys Glu
 140                 145                 150                 155

 ccc tcc ttc ttc ccc ttc ctg aac agc cag gac gcc ttc ctc aag ctg      529
 Pro Ser Phe Phe Pro Phe Leu Asn Ser Gln Asp Ala Phe Leu Lys Leu
                 160                 165                 170

 cag gtg ccc tgt gac agc acc gag tcg gag atg aac cac ctg tac ccg      577
 Gln Val Pro Cys Asp Ser Thr Glu Ser Glu Met Asn His Leu Tyr Pro
             175                 180                 185

 gcg ttc gcc cag cct ggc cag gag tgc tac ctg cag aag gag cct ctg      625
 Ala Phe Ala Gln Pro Gly Gln Glu Cys Tyr Leu Gln Lys Glu Pro Leu
         190                 195                 200

 ctc ttc agc tgc gcc ggc tcc aac acc aag tac cgc cgg ctc tgc ccc      673
 Leu Phe Ser Cys Ala Gly Ser Asn Thr Lys Tyr Arg Arg Leu Cys Pro
     205                 210                 215

 tgc cgc gac ttc cgc aag ggc cag gtg gcc ttg tgc cag ggc tgt ctg      721
 Cys Arg Asp Phe Arg Lys Gly Gln Val Ala Leu Cys Gln Gly Cys Leu
 220                 225                 230                 235

 tga atcc gcctctgccg ccctgcctgg cacccacgct ggctctctcc tgccgcggga      778
 






      <210> 78
      <211> 636
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (13)..(504)

      <400> 78
 aagaaaggct gg    atg aga atg atc agc ttt atc agg agt ttt tgc aag      48
                  Met Arg Met Ile Ser Phe Ile Arg Ser Phe Cys Lys
                    1               5                  10

 tac cgc aga ttt atg ttg aat cct agt aag cgc cag gaa ttt gaa gac       96
 Tyr Arg Arg Phe Met Leu Asn Pro Ser Lys Arg Gln Glu Phe Glu Asp
          15                  20                  25

 tat ctt cac cag gaa atg caa aat agc aag gaa aat ttc acc aca gca      144
 Tyr Leu His Gln Glu Met Gln Asn Ser Lys Glu Asn Phe Thr Thr Ala
      30                  35                  40

 cac aac aca tcg gga cgt tca gct cca ccc tcc aca aat gtc cgg agt      192
 His Asn Thr Ser Gly Arg Ser Ala Pro Pro Ser Thr Asn Val Arg Ser
  45                  50                  55                  60

 gca gac caa gag aat gga gaa ata acc ctt gta aag cgt cgt ata ttt      240
 Ala Asp Gln Glu Asn Gly Glu Ile Thr Leu Val Lys Arg Arg Ile Phe
                  65                  70                  75

 ggc cac agg att atc act gtc aac ttt gcg atc aat gat cta tat ttc      288
 Gly His Arg Ile Ile Thr Val Asn Phe Ala Ile Asn Asp Leu Tyr Phe
              80                  85                  90

 ttt tct gaa atg gag aaa ttt aat gat ctg gtc agt tca gcc cac atg      336
 Phe Ser Glu Met Glu Lys Phe Asn Asp Leu Val Ser Ser Ala His Met
          95                 100                 105

 ctg cag gtc aac cgg gca tat aat gag aat gat gtg atc cta atg cgg      384
 Leu Gln Val Asn Arg Ala Tyr Asn Glu Asn Asp Val Ile Leu Met Arg
     110                 115                 120

 tcc aaa atg aac att atc caa aaa ctc ttc ctg aat tct gac atc cct      432
 Ser Lys Met Asn Ile Ile Gln Lys Leu Phe Leu Asn Ser Asp Ile Pro
 125                 130                 135                 140

 cca aag ctg agg gtg aat gtc cct gag ttc cag agg atg cca tcc ttg      480
 Pro Lys Leu Arg Val Asn Val Pro Glu Phe Gln Arg Met Pro Ser Leu
                 145                 150                 155

 ctg cca tca cag agg gct acc tag atcggagcgt cttccatggg gctatcatgt     534
 Leu Pro Ser Gln Arg Ala Thr 
             160

 ctgtcttccc cgttgttatg tacttctgga aaagggggaa gaagttcaag gacagaaaaa    594

 gccctcctaa atctacggac aagtatcctt tctcgagtgg ag                       636




      <210> 79
      <211> 1101
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (155)..(430)

      <400> 79
 atttaagcag gctggcatca gcaaacacag cttccaaacc cagggcttgc gcttgccttt     60

 gcctcttcca cactaatgac agactgcccc actgagaagg gtctagcgga gcacaggtca    120

 ccagctgggc aacattcaga aagttagtct tcct    atg ctc att ttc ctg ggc     172
                                          Met Leu Ile Phe Leu Gly
                                            1               5

 tgt tac aga aga aga ctg gaa gag cgc gca ggg acc atg tcg gcg gag      220
 Cys Tyr Arg Arg Arg Leu Glu Glu Arg Ala Gly Thr Met Ser Ala Glu
              10                  15                  20

 acc gcg agc ggc ccc aca gag gac cag gtg gaa atc ctg gag tac aac      268
 Thr Ala Ser Gly Pro Thr Glu Asp Gln Val Glu Ile Leu Glu Tyr Asn
          25                  30                  35

 ttc aac aag gtc gac aag cac ccg gat tcc acc acg ctg tgc ctc atc      316
 Phe Asn Lys Val Asp Lys His Pro Asp Ser Thr Thr Leu Cys Leu Ile
      40                  45                  50

 gcg gcc gag gca ggc ctt tcc gag gag gag acc cag aaa tgg ttt aag      364
 Ala Ala Glu Ala Gly Leu Ser Glu Glu Glu Thr Gln Lys Trp Phe Lys
  55                  60                  65                  70

 cag cgc ctg gca aag tgg cgg cgc tca gaa ggc ctg ccc tca gag tgc      412
 Gln Arg Leu Ala Lys Trp Arg Arg Ser Glu Gly Leu Pro Ser Glu Cys
                  75                  80                  85

 aga tcc gtc aca gac taa ggagat ggcaggcatt gacagcttca ctccatgaag      466
 Arg Ser Val Thr Asp 
              90

 gccatctctg tttctctcct ccgcttaacc aagctgttgt ggtttttcag catagtgttg    526

 tatgttccat tgctagctgt cctgctgttt aacacagtgt tgtatttttt ttctaaatgt    586

 acataattag aaaagaaaat aacaatagga agctatgtgt atcttctgtg taaagcagtg    646

 gcttcactgg aaaaatggtg tggctagcat ttccctttga gtcatgatga cagatggtgt    706

 gaaaaccatc taagcgttgc ttttgaccat cacctcccag tagccaattt gctttcataa    766

 tccatttagc aatccaggcc tctgttgaaa acgatatatg agggagaaag ggaacacatt    826

 ttccttctga acttacttcc ctaagtcact ttccttatgt atcatctaat acgacgatgg    886

 gtgcgccgaa acaccgacgg ccgtgtctga gtactcaaat acagatccaa ctccttggag    946

 ctatgactga ctcacttgca aagcgccgtg gggcgaagac gaacccatgg aaaagagcct   1006

 agaaaaaacc caggtctgat accatatacg gtgcgcacac tgcacacgga ggggcacagg   1066

 aataacaccg cttgcaacaa caggcgaacc cagca                              1101




      <210> 80
      <211> 2406
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2406)

      <400> 80
  atg acc gtg gag ttc gag gag tgc gtc aag gac tcc ccg cgc ttc agg      48
  Met Thr Val Glu Phe Glu Glu Cys Val Lys Asp Ser Pro Arg Phe Arg
    1               5                  10                  15

 gcg acc att gac gag gtg gag acg gac gtg gtg gag att gag gcc aaa       96
 Ala Thr Ile Asp Glu Val Glu Thr Asp Val Val Glu Ile Glu Ala Lys
              20                  25                  30

 ctg gac aag ctg gtg aag ctg tgc agt ggc atg gtg gaa gcc ggt aag      144
 Leu Asp Lys Leu Val Lys Leu Cys Ser Gly Met Val Glu Ala Gly Lys
          35                  40                  45

 gcc tac gtc agc acc agc agg ctt ttc gtg agc ggc gtc cgc gac ctg      192
 Ala Tyr Val Ser Thr Ser Arg Leu Phe Val Ser Gly Val Arg Asp Leu
      50                  55                  60

 tcc cag cag tgc cag ggc gac acc gtc atc tcg gaa tgt ctg cag agg      240
 Ser Gln Gln Cys Gln Gly Asp Thr Val Ile Ser Glu Cys Leu Gln Arg
  65                  70                  75                  80

 ttc gct gac agc cta cag gag gtg gtg aac tac cac atg atc ctg ttt      288
 Phe Ala Asp Ser Leu Gln Glu Val Val Asn Tyr His Met Ile Leu Phe
                  85                  90                  95

 gac cag gcc cag agg tcc gtg cgg cag cag ctc cag agc ttt gtc aaa      336
 Asp Gln Ala Gln Arg Ser Val Arg Gln Gln Leu Gln Ser Phe Val Lys
             100                 105                 110

 gag gat gtg cgg aag ttc aag gag aca aag aag cag ttt gac aag gtg      384
 Glu Asp Val Arg Lys Phe Lys Glu Thr Lys Lys Gln Phe Asp Lys Val
         115                 120                 125

 cgg gag gac ctg gag ctg tcc ctg gtg agg aac gcc cag gcc ccg agg      432
 Arg Glu Asp Leu Glu Leu Ser Leu Val Arg Asn Ala Gln Ala Pro Arg
     130                 135                 140

 cac cgg ccc cac gag gtg gag gaa gcc acc ggg gcc ctc acc ctc acc      480
 His Arg Pro His Glu Val Glu Glu Ala Thr Gly Ala Leu Thr Leu Thr
 145                 150                 155                 160

 agg aag tgc ttc cgc cac ctg gca ctg gac tat gtg ctc cag atc aat      528
 Arg Lys Cys Phe Arg His Leu Ala Leu Asp Tyr Val Leu Gln Ile Asn
                 165                 170                 175

 gtt ctg cag gcc aag aag aag ttt gag atc ctg gac tct atg ctg tcc      576
 Val Leu Gln Ala Lys Lys Lys Phe Glu Ile Leu Asp Ser Met Leu Ser
             180                 185                 190

 ttc atg cac gcc cag tcc agc ttc ttc cag cag ggc tac agc ctc ctg      624
 Phe Met His Ala Gln Ser Ser Phe Phe Gln Gln Gly Tyr Ser Leu Leu
         195                 200                 205

 cac cag ctg gac ccc tac atg aag aag ctg gca gcc gag ctg gac cag      672
 His Gln Leu Asp Pro Tyr Met Lys Lys Leu Ala Ala Glu Leu Asp Gln
     210                 215                 220

 ctg gtg atc gac tct gcg gtg gaa aag cgt gag atg gag cga aag cac      720
 Leu Val Ile Asp Ser Ala Val Glu Lys Arg Glu Met Glu Arg Lys His
 225                 230                 235                 240

 gcc gcc atc cag cag cgg acg ctg ctg cag gac ttc tcc tac gat gag      768
 Ala Ala Ile Gln Gln Arg Thr Leu Leu Gln Asp Phe Ser Tyr Asp Glu
                 245                 250                 255

 tcc aaa gtg gag ttt gac gtg gac gcg ccc agt ggg gtg gtg atg gag      816
 Ser Lys Val Glu Phe Asp Val Asp Ala Pro Ser Gly Val Val Met Glu
             260                 265                 270

 ggc tac ctc ttc aag agg gcc agc aac gct ttc aag aca tgg aac cgg      864
 Gly Tyr Leu Phe Lys Arg Ala Ser Asn Ala Phe Lys Thr Trp Asn Arg
         275                 280                 285

 cgc tgg ttc tcc att cag aac agc cag ctg gtc tac cag aag aag ctc      912
 Arg Trp Phe Ser Ile Gln Asn Ser Gln Leu Val Tyr Gln Lys Lys Leu
     290                 295                 300

 aag gat gcc ctc acc gtg gtg gtg gat gac ctc cgc ctg tgc tct gtg      960
 Lys Asp Ala Leu Thr Val Val Val Asp Asp Leu Arg Leu Cys Ser Val
 305                 310                 315                 320

 aag ccg tgt gag gac atc gag cgg agg ttc tgc ttc gag gtg ctg tca     1008
 Lys Pro Cys Glu Asp Ile Glu Arg Arg Phe Cys Phe Glu Val Leu Ser
                 325                 330                 335

 ccc acc aag agc tgc atg ctg cag gct gac tcc gag aag ctg cgg caa     1056
 Pro Thr Lys Ser Cys Met Leu Gln Ala Asp Ser Glu Lys Leu Arg Gln
             340                 345                 350

 gcc tgg gtc cag gct gtg cag gcc agc atc gcc tcc gcc tac cgc gag     1104
 Ala Trp Val Gln Ala Val Gln Ala Ser Ile Ala Ser Ala Tyr Arg Glu
         355                 360                 365

 agc cct gac agt tgc tat agc gag agg ctg gac cgc aca gca tcc ccg     1152
 Ser Pro Asp Ser Cys Tyr Ser Glu Arg Leu Asp Arg Thr Ala Ser Pro
     370                 375                 380

 tcc acg agc agc atc gac tcc gcc acc gac act cgg gag cgt ggc gtg     1200
 Ser Thr Ser Ser Ile Asp Ser Ala Thr Asp Thr Arg Glu Arg Gly Val
 385                 390                 395                 400

 aag ggc gag agt gtg ctg cag cgt gtg cag agt gtg gcc ggc aac agc     1248
 Lys Gly Glu Ser Val Leu Gln Arg Val Gln Ser Val Ala Gly Asn Ser
                 405                 410                 415

 cag tgc ggc gac tgc ggc cag ccg gac ccc cgc tgg gcc agc atc aac     1296
 Gln Cys Gly Asp Cys Gly Gln Pro Asp Pro Arg Trp Ala Ser Ile Asn
             420                 425                 430

 ctg ggc gtg ctg ctc tgc att gag tgc tcc ggc atc cac agg agc ctg     1344
 Leu Gly Val Leu Leu Cys Ile Glu Cys Ser Gly Ile His Arg Ser Leu
         435                 440                 445

 ggt gtc cac tgc tcc aag gtg cgg tcc ctg acg ctg gac tcg tgg gag     1392
 Gly Val His Cys Ser Lys Val Arg Ser Leu Thr Leu Asp Ser Trp Glu
     450                 455                 460

 cct gag ctg cta aag ctg atg tgt gag ctt gga aac agc gct gtg aat     1440
 Pro Glu Leu Leu Lys Leu Met Cys Glu Leu Gly Asn Ser Ala Val Asn
 465                 470                 475                 480

 cag atc tat gag gcc cag tgt gag ggt gca ggc agc agg aaa ccc aca     1488
 Gln Ile Tyr Glu Ala Gln Cys Glu Gly Ala Gly Ser Arg Lys Pro Thr
                 485                 490                 495

 gcc agc agc tcc cgg cag gac aag gag gcc tgg atc aag gac aaa tac     1536
 Ala Ser Ser Ser Arg Gln Asp Lys Glu Ala Trp Ile Lys Asp Lys Tyr
             500                 505                 510

 gtg gaa aag aag ttt ctg cgg aag gcg ccc atg gca cca gcc ctg gag     1584
 Val Glu Lys Lys Phe Leu Arg Lys Ala Pro Met Ala Pro Ala Leu Glu
         515                 520                 525

 gcc cca aga cgc tgg agg gtg cag aag tgc ctg cgg ccc cac agc tct     1632
 Ala Pro Arg Arg Trp Arg Val Gln Lys Cys Leu Arg Pro His Ser Ser
     530                 535                 540

 ccc cgc gct ccc act gcc cgc cgc aag gtc cgg ctt gag ccc gtt ctg     1680
 Pro Arg Ala Pro Thr Ala Arg Arg Lys Val Arg Leu Glu Pro Val Leu
 545                 550                 555                 560

 ccc tgt gtg gcc gct ctg tcc tca gtg ggc acc ctg gat cgt aag ttc     1728
 Pro Cys Val Ala Ala Leu Ser Ser Val Gly Thr Leu Asp Arg Lys Phe
                 565                 570                 575

 cgc cga gac tcc ctc ttc tgt ccc gac gag ctg gac tcg ctc ttc tcc     1776
 Arg Arg Asp Ser Leu Phe Cys Pro Asp Glu Leu Asp Ser Leu Phe Ser
             580                 585                 590

 tac ttc gac gca ggg gcc gca ggg gct ggc cct cgc aag ggt gca gag     1824
 Tyr Phe Asp Ala Gly Ala Ala Gly Ala Gly Pro Arg Lys Gly Ala Glu
         595                 600                 605

 tcg gag gag tcc agc ggt gag gca gac ggg gac act gag gcc gag gcc     1872
 Ser Glu Glu Ser Ser Gly Glu Ala Asp Gly Asp Thr Glu Ala Glu Ala
     610                 615                 620

 tgg ggc ctg gcg gac gtg cgc gag ctg cac ccg ggg ctc ttg gcg cac     1920
 Trp Gly Leu Ala Asp Val Arg Glu Leu His Pro Gly Leu Leu Ala His
 625                 630                 635                 640

 cgc gca gcg cgt gcc cgc gac ctt cct gcg ctg gcg gcg gcg ctg gcc     1968
 Arg Ala Ala Arg Ala Arg Asp Leu Pro Ala Leu Ala Ala Ala Leu Ala
                 645                 650                 655

 cac ggg gcc gag gtc aac tgg gcg gac gcg gag gat gag ggc aag acg     2016
 His Gly Ala Glu Val Asn Trp Ala Asp Ala Glu Asp Glu Gly Lys Thr
             660                 665                 670

 ccg ctg gtg cag gcc gtg cta ggg ggc tcc ttg atc gtc tgt gag ttc     2064
 Pro Leu Val Gln Ala Val Leu Gly Gly Ser Leu Ile Val Cys Glu Phe
         675                 680                 685

 ctg ctg caa aac gga gcg gac gtg aac caa aga gac agc cgg ggc cgg     2112
 Leu Leu Gln Asn Gly Ala Asp Val Asn Gln Arg Asp Ser Arg Gly Arg
     690                 695                 700

 gcg ccc ctg cac cac gcc acg ctg ctg ggc cgc acc ggc cag gtt tgc     2160
 Ala Pro Leu His His Ala Thr Leu Leu Gly Arg Thr Gly Gln Val Cys
 705                 710                 715                 720

 ctg ttc ctg aag cgg ggc gcg gac cag cac gcc ctg gac caa gag cag     2208
 Leu Phe Leu Lys Arg Gly Ala Asp Gln His Ala Leu Asp Gln Glu Gln
                 725                 730                 735

 cgg gac ccg ttg gcc atc gca gtg cag gcg gcc aac gct gac atc gtg     2256
 Arg Asp Pro Leu Ala Ile Ala Val Gln Ala Ala Asn Ala Asp Ile Val
             740                 745                 750

 aca ctg ctc cgt ctg gcg cgc atg gcg gag gaa atg cgc gag gcc gag     2304
 Thr Leu Leu Arg Leu Ala Arg Met Ala Glu Glu Met Arg Glu Ala Glu
         755                 760                 765

 gct gcc cct ggt ccc ccg ggc gcc ctg gcg ggc agc ccc acg gag ctc     2352
 Ala Ala Pro Gly Pro Pro Gly Ala Leu Ala Gly Ser Pro Thr Glu Leu
     770                 775                 780

 cag ttc cgc agg tgt atc cag gag ttc atc agc ctc cac ctg gaa gag     2400
 Gln Phe Arg Arg Cys Ile Gln Glu Phe Ile Ser Leu His Leu Glu Glu
 785                 790                 795                 800

 agc tag                                                             2406
 Ser 






      <210> 81
      <211> 1118
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (507)..(1064)

      <400> 81
 ccctggagcc tcggcaagtc atttggcttc ttcgcgtctt tcatgtgtct tctccagact     60

 gtaagcttcc tgtggacaag gcctgctccg ttcaaggctc aatctccagc tcctgacaca    120

 ccatgcgcta ggtgctcagt cactaatggt ctcgcgaagg agtgatcagt gagtgaagca    180

 ggggctgctg catgggaaag gtgagcgggc tggaaatggg tagtccccgc ggcgtctccc    240

 agtcgggctc ctcccgagga ggaaggaagg agagacccca ggtgtagtcg aggggccggg    300

 agggaggagg ggagggtcgc tccaccctgg agcgggaatg ctgcagggca gctccgggtc    360

 gccaggcggc ggtttccagg caacgaccga acacagacgc gggctagacg ctggcgctga    420

 gcaacctgag gcctgcagac tccgactggg cccctgggct ggcgggacgg accgcggcca    480

 aggcgggggc gctggacggt ggcggc atg gag gac gac gag gag gag acc acc     533
                              Met Glu Asp Asp Glu Glu Glu Thr Thr
                                1               5

 gcg tcc acg ctg cgg ggc aag ccc aac cgc cgc ccg tct cgg cgc agt      581
 Ala Ser Thr Leu Arg Gly Lys Pro Asn Arg Arg Pro Ser Arg Arg Ser
  10                  15                  20                  25

 cgg act tca gcc aat gcg ggg gcg ctg gac ggt ggc ggc atg gag gac      629
 Arg Thr Ser Ala Asn Ala Gly Ala Leu Asp Gly Gly Gly Met Glu Asp
                  30                  35                  40

 gac gag gag gag acc acc gcg tcc acg ctg cgg ggc aag ccc agg ccg      677
 Asp Glu Glu Glu Thr Thr Ala Ser Thr Leu Arg Gly Lys Pro Arg Pro
              45                  50                  55

 ccg ccc gtc tcg gcg cag tcc gcc ttc agc tac atc ccg ccg cgg cgc      725
 Pro Pro Val Ser Ala Gln Ser Ala Phe Ser Tyr Ile Pro Pro Arg Arg
          60                  65                  70

 ctg gac ccc aaa gag cac agc tac tac tac cgc ccg gcg cgg aca gga      773
 Leu Asp Pro Lys Glu His Ser Tyr Tyr Tyr Arg Pro Ala Arg Thr Gly
      75                  80                  85

 att att tcc ctc tat gat tgt att ttt aag agg cgc cta gat tat gat      821
 Ile Ile Ser Leu Tyr Asp Cys Ile Phe Lys Arg Arg Leu Asp Tyr Asp
  90                  95                 100                 105

 cag aag ttg cac cga gat gac aga gaa cat gca aaa agc ctg gga ctt      869
 Gln Lys Leu His Arg Asp Asp Arg Glu His Ala Lys Ser Leu Gly Leu
                 110                 115                 120

 cat gtt aac gaa gag gaa cag gag agg ccg gtt gga gtg ctg acg tct      917
 His Val Asn Glu Glu Glu Gln Glu Arg Pro Val Gly Val Leu Thr Ser
             125                 130                 135

 tct gtc tat ggg aag cgc atc aat cag ccc att gag ccc cta aac cgg      965
 Ser Val Tyr Gly Lys Arg Ile Asn Gln Pro Ile Glu Pro Leu Asn Arg
         140                 145                 150

 gac ttt ggc cgt gcc aac cat gtg cag gct gac ttc tac agg aag aac     1013
 Asp Phe Gly Arg Ala Asn His Val Gln Ala Asp Phe Tyr Arg Lys Asn
     155                 160                 165

 gac atc ccc agc ctc aag gaa ccc ggc ttt ggg cac att gct cca tcc     1061
 Asp Ile Pro Ser Leu Lys Glu Pro Gly Phe Gly His Ile Ala Pro Ser
 170                 175                 180                 185

 tga agca tccccgtggc ccacagggca tgtccgatac cctgtggcct ggcaagtttg     1118
 






      <210> 82
      <211> 3151
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (356)..(3097)

      <400> 82
 ggggtaaaag tcataactgc cattgtttat attttatctt tcccagaatg tgacacaaac     60

 agattttaac aaatagcaac agtgtaattt cttacagatt attatttcac caacagattt    120

 aactacacca ctaaaaaaac gaagatttta tcagttgcta gattcggttt actcagaaac    180

 ctccacacct actccttccc cgtatgctac accaactcac accgatatta ctcctatgga    240

 cccatctttt gccacgcctc cacggataaa atcagatgat gaaacttgta gaaatggtta    300

 taaacccata tattcaccag ttaccccagt aactcctggt acaccaggaa atacc atg     358
                                                              Met
                                                                1

 cac ttt gag aat att tct tcc cca gaa agt tct cca gaa ata aag aga      406
 His Phe Glu Asn Ile Ser Ser Pro Glu Ser Ser Pro Glu Ile Lys Arg
               5                  10                  15

 cgc act tat agt caa gag gga tat gac aga tct tca acc atg tta aca      454
 Arg Thr Tyr Ser Gln Glu Gly Tyr Asp Arg Ser Ser Thr Met Leu Thr
          20                  25                  30

 ttg ggg cct ttt aga aat tct aat tta act gaa ctg ggt ctg caa gaa      502
 Leu Gly Pro Phe Arg Asn Ser Asn Leu Thr Glu Leu Gly Leu Gln Glu
      35                  40                  45

 ata aag act att ggt tat acg agc cct agg agt agg act gaa gtc aac      550
 Ile Lys Thr Ile Gly Tyr Thr Ser Pro Arg Ser Arg Thr Glu Val Asn
  50                  55                  60                  65

 agg cag tgt cct gga gaa aag gaa cct gtg tca gac ctt cag cta gga      598
 Arg Gln Cys Pro Gly Glu Lys Glu Pro Val Ser Asp Leu Gln Leu Gly
                  70                  75                  80

 ctc gat gca gtt gag cca act gcc cta cat aaa acc ctg gaa acg cct      646
 Leu Asp Ala Val Glu Pro Thr Ala Leu His Lys Thr Leu Glu Thr Pro
              85                  90                  95

 gca cat gac agg gct gag ccc aac agc caa ctg gac tcg act cac tct      694
 Ala His Asp Arg Ala Glu Pro Asn Ser Gln Leu Asp Ser Thr His Ser
         100                 105                 110

 gga cgg ggc aca atg tat tct tcc tgg gta aag agc cct gac aga aca      742
 Gly Arg Gly Thr Met Tyr Ser Ser Trp Val Lys Ser Pro Asp Arg Thr
     115                 120                 125

 gga gtt aac ttc tca gtg aac tcc aac ttg agg gac ctg aca ccc tcg      790
 Gly Val Asn Phe Ser Val Asn Ser Asn Leu Arg Asp Leu Thr Pro Ser
 130                 135                 140                 145

 cat cag ttg gag gtt gga gga ggc ttc cga ata agt gag tca aag tgc      838
 His Gln Leu Glu Val Gly Gly Gly Phe Arg Ile Ser Glu Ser Lys Cys
                 150                 155                 160

 ctg atg cag gat gat act aga ggc atg ttt atg gaa aca act gtg ttt      886
 Leu Met Gln Asp Asp Thr Arg Gly Met Phe Met Glu Thr Thr Val Phe
             165                 170                 175

 tgt act tcc gaa gat ggg ctt gta tct ggt ttc gga cgg act gtt aat      934
 Cys Thr Ser Glu Asp Gly Leu Val Ser Gly Phe Gly Arg Thr Val Asn
         180                 185                 190

 gac aat ttg atc gac ggg aat tgc aca ccc cag aat cca cca caa aag      982
 Asp Asn Leu Ile Asp Gly Asn Cys Thr Pro Gln Asn Pro Pro Gln Lys
     195                 200                 205

 aaa aag gtt tct cta tta gaa tac cgt aag aga caa cgt gaa gct agg     1030
 Lys Lys Val Ser Leu Leu Glu Tyr Arg Lys Arg Gln Arg Glu Ala Arg
 210                 215                 220                 225

 aaa agt ggc tct aag aca gag aac ttt cca ctc att agt gta tca ccc     1078
 Lys Ser Gly Ser Lys Thr Glu Asn Phe Pro Leu Ile Ser Val Ser Pro
                 230                 235                 240

 cat gca agt gga agc ttg agc aac aat ggt gat ggc tgt gcc agc agt     1126
 His Ala Ser Gly Ser Leu Ser Asn Asn Gly Asp Gly Cys Ala Ser Ser
             245                 250                 255

 aat gac aat ggg gag cag gtg gac cac act gct agc cta cct tta cca     1174
 Asn Asp Asn Gly Glu Gln Val Asp His Thr Ala Ser Leu Pro Leu Pro
         260                 265                 270

 aca cca gct aca gtt tat aat gcc act tct gaa gaa act agc aat aac     1222
 Thr Pro Ala Thr Val Tyr Asn Ala Thr Ser Glu Glu Thr Ser Asn Asn
     275                 280                 285

 tgc cct gtt aag gat gct act gct agt gag aag aat gaa cca gaa gtt     1270
 Cys Pro Val Lys Asp Ala Thr Ala Ser Glu Lys Asn Glu Pro Glu Val
 290                 295                 300                 305

 caa tgg act gcc tca act tca gtg gaa caa gtc aga gaa agg agt tat     1318
 Gln Trp Thr Ala Ser Thr Ser Val Glu Gln Val Arg Glu Arg Ser Tyr
                 310                 315                 320

 cag aga gct tta ctt ctc agt gat cac cga aaa gat aaa gat agt ggg     1366
 Gln Arg Ala Leu Leu Leu Ser Asp His Arg Lys Asp Lys Asp Ser Gly
             325                 330                 335

 gga gaa tca cca tgt gtc tca tgt tca ccg agt cat gtt cag tct tca     1414
 Gly Glu Ser Pro Cys Val Ser Cys Ser Pro Ser His Val Gln Ser Ser
         340                 345                 350

 cct tca tct cat tca aat cac ata ccc cag ttg caa gct aag ggc cca     1462
 Pro Ser Ser His Ser Asn His Ile Pro Gln Leu Gln Ala Lys Gly Pro
     355                 360                 365

 gtc cct tct ttc agt gaa ctt atg gaa gac cct gat cct gaa aat cca     1510
 Val Pro Ser Phe Ser Glu Leu Met Glu Asp Pro Asp Pro Glu Asn Pro
 370                 375                 380                 385

 gaa ccc aca act acg aat gaa tgt cca tcc cca gat act tct caa aat     1558
 Glu Pro Thr Thr Thr Asn Glu Cys Pro Ser Pro Asp Thr Ser Gln Asn
                 390                 395                 400

 act tgt aaa agt cct cca aaa atg agc aag cct ggt tca cct gga tct     1606
 Thr Cys Lys Ser Pro Pro Lys Met Ser Lys Pro Gly Ser Pro Gly Ser
             405                 410                 415

 gta att cct gct caa gca cac ggg aaa ata ttc aca aaa cca gat ccc     1654
 Val Ile Pro Ala Gln Ala His Gly Lys Ile Phe Thr Lys Pro Asp Pro
         420                 425                 430

 caa tgg gac tcc aca gtt agt gca tcc gaa gct gaa aat ggt gtt cac     1702
 Gln Trp Asp Ser Thr Val Ser Ala Ser Glu Ala Glu Asn Gly Val His
     435                 440                 445

 cta aaa aca gag ctc caa caa aaa cag cta tca aat aac aac caa gca     1750
 Leu Lys Thr Glu Leu Gln Gln Lys Gln Leu Ser Asn Asn Asn Gln Ala
 450                 455                 460                 465

 ctt tca aag aat cat cct cct cag aca cac gtt cgt aat tca tct gag     1798
 Leu Ser Lys Asn His Pro Pro Gln Thr His Val Arg Asn Ser Ser Glu
                 470                 475                 480

 caa ctt tca caa aag ctg cct tct gtg cca aca aag ttg cac tgt cct     1846
 Gln Leu Ser Gln Lys Leu Pro Ser Val Pro Thr Lys Leu His Cys Pro
             485                 490                 495

 cca tca cct cac cta gaa aat cct cca aag tca tcc acg cct cac aca     1894
 Pro Ser Pro His Leu Glu Asn Pro Pro Lys Ser Ser Thr Pro His Thr
         500                 505                 510

 cct gta cag cat ggt tat ctt tca cca aag cct cct tca cag cag tta     1942
 Pro Val Gln His Gly Tyr Leu Ser Pro Lys Pro Pro Ser Gln Gln Leu
     515                 520                 525

 gga tct ccc tac agg cct cat cat tca cag tca cct caa gtt gga aca     1990
 Gly Ser Pro Tyr Arg Pro His His Ser Gln Ser Pro Gln Val Gly Thr
 530                 535                 540                 545

 cct cag cga gag cct caa aga aac ttt tat cca gca gca cag aac ctt     2038
 Pro Gln Arg Glu Pro Gln Arg Asn Phe Tyr Pro Ala Ala Gln Asn Leu
                 550                 555                 560

 cca gcc aat act cag cag gca act tct gga aca tta ttt aca cag aca     2086
 Pro Ala Asn Thr Gln Gln Ala Thr Ser Gly Thr Leu Phe Thr Gln Thr
             565                 570                 575

 ccc tca gga caa tct tca gca aca tac agt cag ttt aac caa caa agt     2134
 Pro Ser Gly Gln Ser Ser Ala Thr Tyr Ser Gln Phe Asn Gln Gln Ser
         580                 585                 590

 ctg aac agc acg gca cca ccc cct cca cct cct cca cct cct tct tcg     2182
 Leu Asn Ser Thr Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Ser Ser
     595                 600                 605

 tct tac tat caa aac cag cag ccc tct gca aac ttt cag aat tat aat     2230
 Ser Tyr Tyr Gln Asn Gln Gln Pro Ser Ala Asn Phe Gln Asn Tyr Asn
 610                 615                 620                 625

 cag ctc aaa ggt agt ctt tct caa caa act gtg ttt aca tca gga cca     2278
 Gln Leu Lys Gly Ser Leu Ser Gln Gln Thr Val Phe Thr Ser Gly Pro
                 630                 635                 640

 aat caa gca ctt cct ggc acc aca agc cag caa aca gtt cca gga cac     2326
 Asn Gln Ala Leu Pro Gly Thr Thr Ser Gln Gln Thr Val Pro Gly His
             645                 650                 655

 cac gtg act cca ggg cat ttt ttg ccc tct cag aac cct acc att cac     2374
 His Val Thr Pro Gly His Phe Leu Pro Ser Gln Asn Pro Thr Ile His
         660                 665                 670

 cat caa act gct gct gcc gta gtc ccc cct cct cct cca cca cca cct     2422
 His Gln Thr Ala Ala Ala Val Val Pro Pro Pro Pro Pro Pro Pro Pro
     675                 680                 685

 gct cca gga ccg cac ctt gta caa cag ccg aat tcc cat cag caa cac     2470
 Ala Pro Gly Pro His Leu Val Gln Gln Pro Asn Ser His Gln Gln His
 690                 695                 700                 705

 tct gta gca cat gta gta ggg cct gtt cat gcg gtc acc cct ggg tcg     2518
 Ser Val Ala His Val Val Gly Pro Val His Ala Val Thr Pro Gly Ser
                 710                 715                 720

 cat att cat tct caa act gct gga cac cac tta ccc cca ccc cca ccc     2566
 His Ile His Ser Gln Thr Ala Gly His His Leu Pro Pro Pro Pro Pro
             725                 730                 735

 cct cct ggt cct gcc cct cat cac cat cca cca ccc cat cca tcc aca     2614
 Pro Pro Gly Pro Ala Pro His His His Pro Pro Pro His Pro Ser Thr
         740                 745                 750

 gga ctc caa ggt cta caa gca caa cac cag cat gtt gta aat tca gca     2662
 Gly Leu Gln Gly Leu Gln Ala Gln His Gln His Val Val Asn Ser Ala
     755                 760                 765

 ccc cca cca ccc cct ccg ccg cca cct tcc agt gtt ttg gct tct ggg     2710
 Pro Pro Pro Pro Pro Pro Pro Pro Pro Ser Ser Val Leu Ala Ser Gly
 770                 775                 780                 785

 cat cat acc aca tca gct caa gcc tta cac cac cca cct cat caa gga     2758
 His His Thr Thr Ser Ala Gln Ala Leu His His Pro Pro His Gln Gly
                 790                 795                 800

 cct cca ctt ttt cct tcg agt gct cat cca act gta cca ccg tat ccc     2806
 Pro Pro Leu Phe Pro Ser Ser Ala His Pro Thr Val Pro Pro Tyr Pro
             805                 810                 815

 tca caa gct aca cat cat acc act ttg gga ccg gga ccc cag cac cag     2854
 Ser Gln Ala Thr His His Thr Thr Leu Gly Pro Gly Pro Gln His Gln
         820                 825                 830

 cct tct gga aca ggg cca cat tgt cca tta cct gtc aca ggt cct cat     2902
 Pro Ser Gly Thr Gly Pro His Cys Pro Leu Pro Val Thr Gly Pro His
     835                 840                 845

 ctc cag ccc caa gga cca aac agt att cca aca cct act gct tca ggg     2950
 Leu Gln Pro Gln Gly Pro Asn Ser Ile Pro Thr Pro Thr Ala Ser Gly
 850                 855                 860                 865

 ttc tgt cct cat cct ggc tct gtg gcc ctg cca cat ggg gtt caa gga     2998
 Phe Cys Pro His Pro Gly Ser Val Ala Leu Pro His Gly Val Gln Gly
                 870                 875                 880

 cct cag cag gca tct cca gtg cct gga cag att cca att cac aga gca     3046
 Pro Gln Gln Ala Ser Pro Val Pro Gly Gln Ile Pro Ile His Arg Ala
             885                 890                 895

 cag gtg cca cca aca ttt caa aac aat tac cat ggg tca ggg tgg cat     3094
 Gln Val Pro Pro Thr Phe Gln Asn Asn Tyr His Gly Ser Gly Trp His
         900                 905                 910

 taa aatg gactccaaaa acattttttt aaatgttctg taagataaac tgtatatttc     3151
 






      <210> 83
      <211> 1620
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (454)..(690)

      <400> 83
 ccagtctggc ctccccgaac aggcgccgcc gccagcactc gccgcaggac cggcccgccc     60

 ggctcccggg gtgcgccctc ctcggtcccg cgccctccgg gctcgcaggg acgtctcctc    120

 cctcccggct cgcggccccg cccggcccgg cccccgccca gagccccagc gcgccgagga    180

 tgtgagtcct gctcgcctct ggcggagcag cagccactcg cgcgcggagc cggagcgcag    240

 cgcagcgcag ccgcgggcgc tctccgggcc gctcgcgcga gtgccgcgct cttgccctag    300

 cggcgtcccc cggcctctcg ccggcgccac cgccgcagca gcccgcgggc cgtccccggc    360

 cggccgcccc cggccccagc gccgctgacc ctgtccgccg cgggcgggga cgcgggcgga    420

 ggaggcgccg cggcggagcc cccggacgcg acc atg tcg gag gtg ctg ccc tac     474
                                      Met Ser Glu Val Leu Pro Tyr
                                        1               5

 ggc gac gag aag ctg agc ccc tac ggc gac ggc ggc gac gtg ggc cag      522
 Gly Asp Glu Lys Leu Ser Pro Tyr Gly Asp Gly Gly Asp Val Gly Gln
          10                  15                  20

 atc ttc tcc tgc cgc ctg cag gac acc aac aac ttc ttc ggc gcc ggg      570
 Ile Phe Ser Cys Arg Leu Gln Asp Thr Asn Asn Phe Phe Gly Ala Gly
      25                  30                  35

 cag aac aag cgg ccg ccc aag ctg ggc cag atc ggc cgg agc aag cgg      618
 Gln Asn Lys Arg Pro Pro Lys Leu Gly Gln Ile Gly Arg Ser Lys Arg
  40                  45                  50                  55

 gtt gtt att gaa gat gat agg att gat gac gtg ctg aaa aat atg acc      666
 Val Val Ile Glu Asp Asp Arg Ile Asp Asp Val Leu Lys Asn Met Thr
                  60                  65                  70

 gac aag gca cct cct ggt gtc taa ctcccccaaa gacaatgagt taagggagag     720
 Asp Lys Ala Pro Pro Gly Val 
              75

 aataagaacg gcggtaacag ttattggcaa aaagcatgaa aagagaaagc actttgaaat    780

 ttattactag cttgctaccc acgatgaaat caacaacctg tatctggtat caggccggga    840

 gacagatgag gcgagaggag aggaggagga ggagaaggct ctgggctcct ctgcaaaaat    900

 aaaaataaaa aaataaataa aattttaaaa ataataaaaa ttcactatat acacatataa    960

 agaaataaaa agaagtctca gtttgcagct atttgtcaaa attaatatcc atttcttttt   1020

 atatacggtg aatatggcgc aattatagat ctggatttga accacttaat gaagcggcaa   1080

 caccaggtgt tttgaggtgg tggcattctt cgctgatttg gctgttccca atgtttacat   1140

 tatttaatct tgcaaaaatg gttctgtgca ctttggatgt gaaatgctgg tccagtttta   1200

 ttttttttta tggtggttat cctgtggatg tacaaaaaat tcagaaaatg atctctgtag   1260

 atattctgtt ttattgggtc atctttagaa gttatcagga atgtgtttaa aacaagaaga   1320

 gaacttttct aaggaatgat acatagaaaa gattttattt taaaatgaag tggtaaagct   1380

 tgtgttcttt gtgtgctggc aagctatctg cccaagttaa tgccaaattg gccacatttt   1440

 tttatgtcag aaaaacacag acaacagcaa aacgaaagaa caacagggaa aaacaagaaa   1500

 aaggtggtgg gttttttaat tcccctgagg ctggggtgag cgggggtaat cccaataatg   1560

 ggaggacact cttagggggg gagaatggtc cgggggcaat attgaggcaa gggttagttt   1620




      <210> 84
      <211> 498
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(498)

      <400> 84
  atg act tgc aaa atg tcg cag ctg gaa cgc aac ata gag acc atc atc      48
  Met Thr Cys Lys Met Ser Gln Leu Glu Arg Asn Ile Glu Thr Ile Ile
    1               5                  10                  15

 aac acc ttc cac caa tac tct gtg aag ctg ggg cac cca gac acc ctg       96
 Asn Thr Phe His Gln Tyr Ser Val Lys Leu Gly His Pro Asp Thr Leu
              20                  25                  30

 aac cag ggg gaa ttc aaa gag ctg gtg cga aaa gat ctg caa aat ttt      144
 Asn Gln Gly Glu Phe Lys Glu Leu Val Arg Lys Asp Leu Gln Asn Phe
          35                  40                  45

 ctc aag aag gag aat aag aat gaa aag gtc ata gaa cac atc atg gag      192
 Leu Lys Lys Glu Asn Lys Asn Glu Lys Val Ile Glu His Ile Met Glu
      50                  55                  60

 gac ctg gac aca aat gca gac aag cag ctg agc ttc gag gag ttc atc      240
 Asp Leu Asp Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile
  65                  70                  75                  80

 atg ctg atg gcg agg cta acc tgg gcc tcc cac gag aaa atg cac gag      288
 Met Leu Met Ala Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu
                  85                  90                  95

 ggt gac gag ggc cct ggc cac cac cat aag cca ggc ctc ggg gag ggc      336
 Gly Asp Glu Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly
             100                 105                 110

 acc ccc cta aga cca cag tgg cca aga tca cag tgg cca cgg cca cgg      384
 Thr Pro Leu Arg Pro Gln Trp Pro Arg Ser Gln Trp Pro Arg Pro Arg
         115                 120                 125

 cca cag tca tgg tgg cca cgg cca cag cca cta atc agg agg cca ggc      432
 Pro Gln Ser Trp Trp Pro Arg Pro Gln Pro Leu Ile Arg Arg Pro Gly
     130                 135                 140

 cac cct gcc tct acc caa cca ggg ccc cgg ggc ctg tta tgt caa act      480
 His Pro Ala Ser Thr Gln Pro Gly Pro Arg Gly Leu Leu Cys Gln Thr
 145                 150                 155                 160

 gct tgg ctg tgg ggc tag                                              498
 Ala Trp Leu Trp Gly 
                 165





      <210> 85
      <211> 516
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(516)

      <400> 85
  atg act tgc aaa atg tcg cag ctg gaa cgc aac ata gag acc atc atc      48
  Met Thr Cys Lys Met Ser Gln Leu Glu Arg Asn Ile Glu Thr Ile Ile
    1               5                  10                  15

 aac acc ttc cac caa tac tct gtg aag ctg ggg cac cca gac acc ctg       96
 Asn Thr Phe His Gln Tyr Ser Val Lys Leu Gly His Pro Asp Thr Leu
              20                  25                  30

 aac cag ggg gaa ttc aaa gag ctg gtg cga aaa gat ctg caa aat ttt      144
 Asn Gln Gly Glu Phe Lys Glu Leu Val Arg Lys Asp Leu Gln Asn Phe
          35                  40                  45

 ctc aag aag gag aat aag aat gaa aag gtc ata gaa cac atc atg gag      192
 Leu Lys Lys Glu Asn Lys Asn Glu Lys Val Ile Glu His Ile Met Glu
      50                  55                  60

 gac ctg gac aca aat gca gac aag cag ctg agc ttc gag gag ttc atc      240
 Asp Leu Asp Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile
  65                  70                  75                  80

 atg ctg atg gcg agg cta acc tgg gcc tcc cac gag aaa atg cac gag      288
 Met Leu Met Ala Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu
                  85                  90                  95

 ggt gac gag ggc cct ggc cac cac cat aag cca ggc ctc ggg gag ggc      336
 Gly Asp Glu Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly
             100                 105                 110

 acc ccc cta aga cca cag tgg cca aga tca cag tgg cca cgg cca cgg      384
 Thr Pro Leu Arg Pro Gln Trp Pro Arg Ser Gln Trp Pro Arg Pro Arg
         115                 120                 125

 cca cag tca tgg tgg cca cgg cca cag cca cta atc agg agg cca ggc      432
 Pro Gln Ser Trp Trp Pro Arg Pro Gln Pro Leu Ile Arg Arg Pro Gly
     130                 135                 140

 cac cct gcc tct acc caa cca ggg ccc cgg ggc ctg tta tgt caa act      480
 His Pro Ala Ser Thr Gln Pro Gly Pro Arg Gly Leu Leu Cys Gln Thr
 145                 150                 155                 160

 gtt ttg gct gtg ggg cta ggg gct ggg gcc aaa taa                      516
 Val Leu Ala Val Gly Leu Gly Ala Gly Ala Lys 
                 165                 170





      <210> 86
      <211> 417
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(417)

      <400> 86
  atg act tgc aaa atg tcg cag ctg gaa cgc aac ata gag acc atc atc      48
  Met Thr Cys Lys Met Ser Gln Leu Glu Arg Asn Ile Glu Thr Ile Ile
    1               5                  10                  15

 aac acc ttc cac caa tac tct gtg aag ctg ggg cac cca gac acc ctg       96
 Asn Thr Phe His Gln Tyr Ser Val Lys Leu Gly His Pro Asp Thr Leu
              20                  25                  30

 aac cag ggg gaa ttc aaa gag ctg gtg cga aaa gat ctg caa aat ttt      144
 Asn Gln Gly Glu Phe Lys Glu Leu Val Arg Lys Asp Leu Gln Asn Phe
          35                  40                  45

 ctc aag aag gag aat aag aat gaa aag gtc ata gaa cac atc atg gag      192
 Leu Lys Lys Glu Asn Lys Asn Glu Lys Val Ile Glu His Ile Met Glu
      50                  55                  60

 gac ctg gac aca aat gca gac aag cag ctg agc ttc gag gag ttc atc      240
 Asp Leu Asp Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile
  65                  70                  75                  80

 atg ctg atg gcg agg cta acc tgg gcc tcc cac gag aaa atg cac gag      288
 Met Leu Met Ala Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu
                  85                  90                  95

 ggt gac gag ggc cct ggc cac cac cat aag cca ggc ctc ggg gag ggc      336
 Gly Asp Glu Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly
             100                 105                 110

 acc ccc cta aga cca cag tgg cca aga tca cag tgg cca cgg cac ggc      384
 Thr Pro Leu Arg Pro Gln Trp Pro Arg Ser Gln Trp Pro Arg His Gly
         115                 120                 125

 cac agt cat ggt ggc cac ggc cac agc cac taa                          417
 His Ser His Gly Gly His Gly His Ser His 
     130                 135





      <210> 87
      <211> 933
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (15)..(515)

      <400> 87
 ggaggtggcc ccgg  atg ctg cgg cgc ccg cgt ggc cgg gct ggc tgc ggc      50
                  Met Leu Arg Arg Pro Arg Gly Arg Ala Gly Cys Gly
                    1               5                  10

 cgc cct ggg ccg ggc ccc acc gga cgg cat gtc ggg ccc cag gcc tgt       98
 Arg Pro Gly Pro Gly Pro Thr Gly Arg His Val Gly Pro Gln Ala Cys
          15                  20                  25

 ggt gct gag cgg gcc ttc ggg agc tgg gaa gag cac cct gct gaa gag      146
 Gly Ala Glu Arg Ala Phe Gly Ser Trp Glu Glu His Pro Ala Glu Glu
      30                  35                  40

 gct gct cca gga gca cag cgg cat ctt tgg ctt cag cgt gtc cca tac      194
 Ala Ala Pro Gly Ala Gln Arg His Leu Trp Leu Gln Arg Val Pro Tyr
  45                  50                  55                  60

 cac gag gaa ccc gag gcc cgg cga gga gaa cgg caa aga tta cta ctt      242
 His Glu Glu Pro Glu Ala Arg Arg Gly Glu Arg Gln Arg Leu Leu Leu
                  65                  70                  75

 tgt aac cag gag gtg atg cag cgt gac ata gca gcc ggc gac ttc atc      290
 Cys Asn Gln Glu Val Met Gln Arg Asp Ile Ala Ala Gly Asp Phe Ile
              80                  85                  90

 gag cat gcc gag ttc tcg ggg aac ctg tat ggc acg agc aag gtg gcg      338
 Glu His Ala Glu Phe Ser Gly Asn Leu Tyr Gly Thr Ser Lys Val Ala
          95                 100                 105

 gtg cag gcc gtg cag gcc atg aac cgc atc tgt gtg ctg gac gtg gac      386
 Val Gln Ala Val Gln Ala Met Asn Arg Ile Cys Val Leu Asp Val Asp
     110                 115                 120

 ctg cag ggt gtg cgg aac atc aag gcc acc gat ctg cgg cca tct aca      434
 Leu Gln Gly Val Arg Asn Ile Lys Ala Thr Asp Leu Arg Pro Ser Thr
 125                 130                 135                 140

 tct ctg tgc agc cgc ctt cac tgc acg tgc tgg agc agc ggc tgc ggc      482
 Ser Leu Cys Ser Arg Leu His Cys Thr Cys Trp Ser Ser Gly Cys Gly
                 145                 150                 155

 agc gca aca ctg aaa ccg agg aga gcc tgg tga agcggctg gctgctgccc      533
 Ser Ala Thr Leu Lys Pro Arg Arg Ala Trp 
             160                 165

 aggccgacat ggagagcagc aaggagcccg gctgtttgat gtggtcatca ttaacgacag    593

 cctggaccag gcctacgcag agctgaagga ggcgctctct gaggaaatca agaaagctca    653

 aaggaccggc gccttgaggc ttgcttgtct gttctcggca ccccggggcc atacaggaca    713

 ggacagcagc attgagccac cccttgggca ggcgataccg gcagtctgtg cccttggcag    773

 catgtggagg gggggagatg gtgccctgtg gttggacctc ctggggtgac cccgaccagc    833

 tcgttggtgg cctgtcctat ttcaacctgg accagggtga atctataaat actgtggtta    893

 actccaaaaa aaaaaaaaaa aaaaaccgcc tttgggaaaa                          933




      <210> 88
      <211> 552
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(552)

      <400> 88
  atg gtt gtt cag gta gtg ccg cag ggc tgt ggg ata atc cgg tat gac      48
  Met Val Val Gln Val Val Pro Gln Gly Cys Gly Ile Ile Arg Tyr Asp
    1               5                  10                  15

 gcc agt ggc tcc cac gct gaa ggc tgc ttc aaa atc cga ctc ttc tgg       96
 Ala Ser Gly Ser His Ala Glu Gly Cys Phe Lys Ile Arg Leu Phe Trp
              20                  25                  30

 tcc cca cag act cag aga gaa ccc acc atg gtg ctg tct cct gcc gac      144
 Ser Pro Gln Thr Gln Arg Glu Pro Thr Met Val Leu Ser Pro Ala Asp
          35                  40                  45

 aag acc aac gtc aag gcc gcc tgg ggt aag gtc ggc gcg cac gct ggc      192
 Lys Thr Asn Val Lys Ala Ala Trp Gly Lys Val Gly Ala His Ala Gly
      50                  55                  60

 gag tat ggt gcg gag gcc ctg gag agg atg ttc ctg tcc ttc ccc acc      240
 Glu Tyr Gly Ala Glu Ala Leu Glu Arg Met Phe Leu Ser Phe Pro Thr
  65                  70                  75                  80

 acc aag acc tac ttc ccg cac ttc gac ctg agc cac ggc tct gcc cag      288
 Thr Lys Thr Tyr Phe Pro His Phe Asp Leu Ser His Gly Ser Ala Gln
                  85                  90                  95

 gtt aag ggc cac ggc aag aag gtg gcc gac gcg ctg acc aac gcc gtg      336
 Val Lys Gly His Gly Lys Lys Val Ala Asp Ala Leu Thr Asn Ala Val
             100                 105                 110

 gcg cac gtg gac gac atg ccc aac gcg ctg tcc gcc ctg agc gac ctg      384
 Ala His Val Asp Asp Met Pro Asn Ala Leu Ser Ala Leu Ser Asp Leu
         115                 120                 125

 cac gcg cac aag ctt cgg gtg gac ccg gtc aac ttc aag ctc cta agc      432
 His Ala His Lys Leu Arg Val Asp Pro Val Asn Phe Lys Leu Leu Ser
     130                 135                 140

 cac tgc ctg ctg gtg acc ctg gcc gcc cac ctc ccc gcc gag ttc acc      480
 His Cys Leu Leu Val Thr Leu Ala Ala His Leu Pro Ala Glu Phe Thr
 145                 150                 155                 160

 cct gcg gtg cac gcc tcc ctg gac aag ttc ctg gct tct gtg agc acc      528
 Pro Ala Val His Ala Ser Leu Asp Lys Phe Leu Ala Ser Val Ser Thr
                 165                 170                 175

 gtg ctg acc tcc aaa tac cgt taa                                      552
 Val Leu Thr Ser Lys Tyr Arg 
             180





      <210> 89
      <211> 1099
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(897)

      <400> 89
  atg ggg ttt gtt aaa gtt gtt aag aat aag gcc tac ttt aag aga tac      48
  Met Gly Phe Val Lys Val Val Lys Asn Lys Ala Tyr Phe Lys Arg Tyr
    1               5                  10                  15

 caa gtg aaa ttt aga aga cga caa gag ggt aaa act ggt tac tat gct       96
 Gln Val Lys Phe Arg Arg Arg Gln Glu Gly Lys Thr Gly Tyr Tyr Ala
              20                  25                  30

 cgg aaa tac ttg gag ata cag gat aaa aat aaa tac aac aca ccc aaa      144
 Arg Lys Tyr Leu Glu Ile Gln Asp Lys Asn Lys Tyr Asn Thr Pro Lys
          35                  40                  45

 tat agg ata gta gtt cat cta acc aac aga gat atc att agt cag att      192
 Tyr Arg Ile Val Val His Leu Thr Asn Arg Asp Ile Ile Ser Gln Ile
      50                  55                  60

 gct tat gcc cgt ata gag ggg gat atg ata gtc tgc gca gca tac gca      240
 Ala Tyr Ala Arg Ile Glu Gly Asp Met Ile Val Cys Ala Ala Tyr Ala
  65                  70                  75                  80

 cac gaa ctg cca aaa tat ggt gtg aag gtt ggc ctg aca aat tat gct      288
 His Glu Leu Pro Lys Tyr Gly Val Lys Val Gly Leu Thr Asn Tyr Ala
                  85                  90                  95

 gca gca tat tgt act ggc ctg ctg ctg gcc cgc agg ctt ctc aat agg      336
 Ala Ala Tyr Cys Thr Gly Leu Leu Leu Ala Arg Arg Leu Leu Asn Arg
             100                 105                 110

 ttt ggc atg gac aag atc tat gaa ggc caa gtg gag gtg act ggt gat      384
 Phe Gly Met Asp Lys Ile Tyr Glu Gly Gln Val Glu Val Thr Gly Asp
         115                 120                 125

 gaa tac aat gtg gaa agc att gat ggt cag cca ggt gcc ttc acc tgc      432
 Glu Tyr Asn Val Glu Ser Ile Asp Gly Gln Pro Gly Ala Phe Thr Cys
     130                 135                 140

 tat ttg gat gca ggc ctt gcc aga act acc act ggc aat aaa gtt ttt      480
 Tyr Leu Asp Ala Gly Leu Ala Arg Thr Thr Thr Gly Asn Lys Val Phe
 145                 150                 155                 160

 ggt gcc ctg aag gga gct gtg gat gga ggc ttg tct atc cct cac agt      528
 Gly Ala Leu Lys Gly Ala Val Asp Gly Gly Leu Ser Ile Pro His Ser
                 165                 170                 175

 acc aaa cga ttc cct ggt tat gat tct gaa agc aag gaa ttt aat gca      576
 Thr Lys Arg Phe Pro Gly Tyr Asp Ser Glu Ser Lys Glu Phe Asn Ala
             180                 185                 190

 gaa gta cat cgg aag cac atc atg ggc cag aat gtt gca gat tac atg      624
 Glu Val His Arg Lys His Ile Met Gly Gln Asn Val Ala Asp Tyr Met
         195                 200                 205

 cgc tac tta atg gaa gaa gat gaa gat gct tac aag aaa cag ttc tct      672
 Arg Tyr Leu Met Glu Glu Asp Glu Asp Ala Tyr Lys Lys Gln Phe Ser
     210                 215                 220

 caa tac ata aag aac agc gta act cca gac atg atg gag gag atg tat      720
 Gln Tyr Ile Lys Asn Ser Val Thr Pro Asp Met Met Glu Glu Met Tyr
 225                 230                 235                 240

 aag aaa ggc tca tgc tgg cta tac gag aga atc cag tct atg aaa aag      768
 Lys Lys Gly Ser Cys Trp Leu Tyr Glu Arg Ile Gln Ser Met Lys Lys
                 245                 250                 255

 aag ccc aag aaa gaa gtt aaa aag aag agg tgg aac cgt ccc aaa atg      816
 Lys Pro Lys Lys Glu Val Lys Lys Lys Arg Trp Asn Arg Pro Lys Met
             260                 265                 270

 tcc ctt gct cag aag aag gat cgg gta gct caa aag aag gca agc ttc      864
 Ser Leu Ala Gln Lys Lys Asp Arg Val Ala Gln Lys Lys Ala Ser Phe
         275                 280                 285

 ctc aga gct cca agg agc ggc tgt gag agc taa accagcga tttctatgat      915
 Leu Arg Ala Pro Arg Ser Gly Cys Glu Ser 
     290                 295

 ttcgatttga tataactttg acttcaggaa acaaaaaaca aatttgggcg cgcccccaat    975

 tttaccactt gtggggcggg caaataacac tgtcggtccg gatcgcgcga tgggtccaaa   1035

 accgggcgct taaccgtgct gttcagctga cccacggagc aaccaaaaag ccttctttct   1095

 cctc                                                                1099




      <210> 90
      <211> 912
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(912)

      <400> 90
  atg cag tta aca tca cac ggg gct gag acg ctg act cgg gga cac aag      48
  Met Gln Leu Thr Ser His Gly Ala Glu Thr Leu Thr Arg Gly His Lys
    1               5                  10                  15

 ctc aag cca aat gtg caa tgc tgg gtc gga agc ccc tta tcc cgg gat       96
 Leu Lys Pro Asn Val Gln Cys Trp Val Gly Ser Pro Leu Ser Arg Asp
              20                  25                  30

 gcg ctc cag gga atc ggg gcg gcc tcc cag ctt agc gtc tgc agg cta      144
 Ala Leu Gln Gly Ile Gly Ala Ala Ser Gln Leu Ser Val Cys Arg Leu
          35                  40                  45

 cgc ggt ttc aag cag caa cgt ctc tcc cag cct agc tgt gca gag gac      192
 Arg Gly Phe Lys Gln Gln Arg Leu Ser Gln Pro Ser Cys Ala Glu Asp
      50                  55                  60

 gac ttt tca aca gag gcc gag agc tgg ccg cct ccg ctc ccc cgg ctc      240
 Asp Phe Ser Thr Glu Ala Glu Ser Trp Pro Pro Pro Leu Pro Arg Leu
  65                  70                  75                  80

 ccg gct cct gcc gcg gtc cca ccc agc tcc cgc ttc ccc cgg ttc cct      288
 Pro Ala Pro Ala Ala Val Pro Pro Ser Ser Arg Phe Pro Arg Phe Pro
                  85                  90                  95

 ggt gcc ctc ggc tgc cct cag ctc tcc cct agc ccg cgg aac gct agg      336
 Gly Ala Leu Gly Cys Pro Gln Leu Ser Pro Ser Pro Arg Asn Ala Arg
             100                 105                 110

 ccc ggg cct gca ggc gac acg cgc ggg cac gca cgg agc acg gcc cgg      384
 Pro Gly Pro Ala Gly Asp Thr Arg Gly His Ala Arg Ser Thr Ala Arg
         115                 120                 125

 ccg cca gac cac ggc cgc cta gcg acc cgg aaa cac tcg cct cca aac      432
 Pro Pro Asp His Gly Arg Leu Ala Thr Arg Lys His Ser Pro Pro Asn
     130                 135                 140

 tgt gac gag gcc cca cgc aga aga ccg ccc cac tct cgt cgc act agg      480
 Cys Asp Glu Ala Pro Arg Arg Arg Pro Pro His Ser Arg Arg Thr Arg
 145                 150                 155                 160

 gac ccc gaa atc cga ccg ccc atg gga agc cac tcg cca gag tct tac      528
 Asp Pro Glu Ile Arg Pro Pro Met Gly Ser His Ser Pro Glu Ser Tyr
                 165                 170                 175

 ctg agc aga atg gct cct gca aag aac agt ggc aag aag aaa atg gac      576
 Leu Ser Arg Met Ala Pro Ala Lys Asn Ser Gly Lys Lys Lys Met Asp
             180                 185                 190

 cat tct gcc atc aac gag gtg atg acc caa gaa tac acc aac att cac      624
 His Ser Ala Ile Asn Glu Val Met Thr Gln Glu Tyr Thr Asn Ile His
         195                 200                 205

 aag cac atc cac aga gtg ggc ttc aag aag cgt gcc cct caa gca ctc      672
 Lys His Ile His Arg Val Gly Phe Lys Lys Arg Ala Pro Gln Ala Leu
     210                 215                 220

 aaa gag atc cag aaa ttt gcc atg aag gag atg gga act cca gat gtg      720
 Lys Glu Ile Gln Lys Phe Ala Met Lys Glu Met Gly Thr Pro Asp Val
 225                 230                 235                 240

 cgc att gac acc agg ctc aac aaa gct gtc tgg gcc aaa gga ata agg      768
 Arg Ile Asp Thr Arg Leu Asn Lys Ala Val Trp Ala Lys Gly Ile Arg
                 245                 250                 255

 aat atc cca tac cgc atc cgt gtg cag ttg tcc aga gaa tat aat gag      816
 Asn Ile Pro Tyr Arg Ile Arg Val Gln Leu Ser Arg Glu Tyr Asn Glu
             260                 265                 270

 gat gaa gat tca cca aat aag ctc tgt act tcg gtt acc tat gta cct      864
 Asp Glu Asp Ser Pro Asn Lys Leu Cys Thr Ser Val Thr Tyr Val Pro
         275                 280                 285

 gtt acc act ttc aaa aat cta cag aca gtc aat gtg gat gag aac taa      912
 Val Thr Thr Phe Lys Asn Leu Gln Thr Val Asn Val Asp Glu Asn 
     290                 295                 300





      <210> 91
      <211> 534
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (192)..(452)

      <220>
      <221> misc_feature
      <222> (1)...(534)
      <223> n = a,t,c or g

      <400> 91
 ggcnggccag gnggggcccc gcnattgann nnccatgagt ncntcctcca ngtcgnggaa     60

 ttcggaaggg atagccagcg cgaaggaagt gctggagtcg tgtgttttgg ctgcgcgtga    120

 tcctgcgtgg gtcgggaggt gtttctgtga aaagcctaaa gattagactg taagaaaaga    180

 aaatagaagc c atg ttt cga aga cct gta tta cag gta ctt cgt cag ttt     230
              Met Phe Arg Arg Pro Val Leu Gln Val Leu Arg Gln Phe
                1               5                  10

 gta aga cat gag tcc gaa aca act acc agt ttg gtt ctt gaa aga tgt      278
 Val Arg His Glu Ser Glu Thr Thr Thr Ser Leu Val Leu Glu Arg Cys
      15                  20                  25

 gat gtc agt caa aag aca aca tgg cac aga ata tca gta ttc cgg cca      326
 Asp Val Ser Gln Lys Thr Thr Trp His Arg Ile Ser Val Phe Arg Pro
  30                  35                  40                  45

 ggc ctc aga gac gtg gca tat caa tat gtg aaa aag ggg tct cga att      374
 Gly Leu Arg Asp Val Ala Tyr Gln Tyr Val Lys Lys Gly Ser Arg Ile
                  50                  55                  60

 tat ttg gaa ggg aaa ata gac tat ggt gaa tac atg gat atg agt gac      422
 Tyr Leu Glu Gly Lys Ile Asp Tyr Gly Glu Tyr Met Asp Met Ser Asp
              65                  70                  75

 cag acg aaa gag aag gag ttg aaa gga tga t tcttctttgc ccattcattg      473
 Gln Thr Lys Glu Lys Glu Leu Lys Gly 
          80                  85

 gtacagtctc atttccaagt catgtataat cctttatggc tttcaaagga caggaattaa    533

 a                                                                    534




      <210> 92
      <211> 1238
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(1128)

      <400> 92
 gtc  atg ttg aat ata tct gaa agc tgt aga agt cct gaa gaa aga atg      48
      Met Leu Asn Ile Ser Glu Ser Cys Arg Ser Pro Glu Glu Arg Met
        1               5                  10                  15

 aag gaa ttt att gga att gtt tgg aat gca gtg aag cat ctc aca cta       96
 Lys Glu Phe Ile Gly Ile Val Trp Asn Ala Val Lys His Leu Thr Leu
                  20                  25                  30

 cag ctt gaa gta caa tct tgt tgt gtg ttt att cca aat gat agc ctg      144
 Gln Leu Glu Val Gln Ser Cys Cys Val Phe Ile Pro Asn Asp Ser Leu
              35                  40                  45

 cct tcc cca agt aca att gta tct ggt gac att cct gga aca gta aga      192
 Pro Ser Pro Ser Thr Ile Val Ser Gly Asp Ile Pro Gly Thr Val Arg
          50                  55                  60

 agt tgg tac cat gga caa acc agc atg ccg gga aca ctt gtc ctc tgt      240
 Ser Trp Tyr His Gly Gln Thr Ser Met Pro Gly Thr Leu Val Leu Cys
      65                  70                  75

 ttg cct caa ata aag att att agt gct ggg cac aag tat atg gaa cct      288
 Leu Pro Gln Ile Lys Ile Ile Ser Ala Gly His Lys Tyr Met Glu Pro
  80                  85                  90                  95

 ctg cag gag att cca ttt gtt atc cca cga ccc atc ctt gaa gaa ggt      336
 Leu Gln Glu Ile Pro Phe Val Ile Pro Arg Pro Ile Leu Glu Glu Gly
                 100                 105                 110

 gat gct ttt cct tgg acg atc agc ttg cat aat ttc agc ata tat acc      384
 Asp Ala Phe Pro Trp Thr Ile Ser Leu His Asn Phe Ser Ile Tyr Thr
             115                 120                 125

 ctt ctt gga aaa caa gtg aca ctt tgc cta gtg gaa cct atg ggt tgc      432
 Leu Leu Gly Lys Gln Val Thr Leu Cys Leu Val Glu Pro Met Gly Cys
         130                 135                 140

 acc tcc act cta gct gtc acg tct caa aaa ctg ctt gct acg gga cct      480
 Thr Ser Thr Leu Ala Val Thr Ser Gln Lys Leu Leu Ala Thr Gly Pro
     145                 150                 155

 gat aca cga cat tca ttt gtt gtc tgt ctc cat gtt gac cta gag tca      528
 Asp Thr Arg His Ser Phe Val Val Cys Leu His Val Asp Leu Glu Ser
 160                 165                 170                 175

 cta gag ata aaa tgc tct aat ccc cag gtc cag ctc ttc tat gaa cta      576
 Leu Glu Ile Lys Cys Ser Asn Pro Gln Val Gln Leu Phe Tyr Glu Leu
                 180                 185                 190

 act gat atc atg aat aag gtc tgg aac aag att cag aag aga ggc aat      624
 Thr Asp Ile Met Asn Lys Val Trp Asn Lys Ile Gln Lys Arg Gly Asn
             195                 200                 205

 ctc aac cta tct cca acc tct cca gag acc atg gca ggg cct gtt cct      672
 Leu Asn Leu Ser Pro Thr Ser Pro Glu Thr Met Ala Gly Pro Val Pro
         210                 215                 220

 act tct cca gtt aga agc agt ata ggc aca gct cct cca gat acc agc      720
 Thr Ser Pro Val Arg Ser Ser Ile Gly Thr Ala Pro Pro Asp Thr Ser
     225                 230                 235

 aca tgc agc cca tct gct gac att ggg act act act gag gga gat tct      768
 Thr Cys Ser Pro Ser Ala Asp Ile Gly Thr Thr Thr Glu Gly Asp Ser
 240                 245                 250                 255

 ata caa gca ggt gag gaa tca cca ttc tca gat tct gtg acc ttg gaa      816
 Ile Gln Ala Gly Glu Glu Ser Pro Phe Ser Asp Ser Val Thr Leu Glu
                 260                 265                 270

 caa act aca agt aat att gga gga acc agt gga cgt gtt agt tta tgg      864
 Gln Thr Thr Ser Asn Ile Gly Gly Thr Ser Gly Arg Val Ser Leu Trp
             275                 280                 285

 atg cag tgg gtg ctt ccc aaa att act ata aag ctc ttt gct cca gat      912
 Met Gln Trp Val Leu Pro Lys Ile Thr Ile Lys Leu Phe Ala Pro Asp
         290                 295                 300

 cct gaa aat aaa ggc aca gag gtt tgt atg gtc agt gaa cta gaa gat      960
 Pro Glu Asn Lys Gly Thr Glu Val Cys Met Val Ser Glu Leu Glu Asp
     305                 310                 315

 ctc agt gct tcc ata gat gtc cag gat gta tat acc aaa gtg aaa tgt     1008
 Leu Ser Ala Ser Ile Asp Val Gln Asp Val Tyr Thr Lys Val Lys Cys
 320                 325                 330                 335

 aaa ata gag agt ttc aat att gat cac tat aga agc agg cca ggg gaa     1056
 Lys Ile Glu Ser Phe Asn Ile Asp His Tyr Arg Ser Arg Pro Gly Glu
                 340                 345                 350

 ggt tgg cag tca gga cat ttt gaa gga gta ttt cta caa tgc aaa gaa     1104
 Gly Trp Gln Ser Gly His Phe Glu Gly Val Phe Leu Gln Cys Lys Glu
             355                 360                 365

 aaa tct gtg gtg aga ccc att tag ttcactatga tttttgaaaa tgtcacttta    1158
 Lys Ser Val Val Arg Pro Ile 
         370

 cactgtttat cttgttattt cataaaatag gactaatggt tacaagactt tgagttcaga   1218

 atcaaattct tattagcctg                                               1238




      <210> 93
      <211> 2875
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (29)..(1249)

      <400> 93
 ggcaagcggc gggccagcga cggcgcga   atg gcg gac tct cag ctg ttc tgt      52
                                  Met Ala Asp Ser Gln Leu Phe Cys
                                    1               5

 gtg gcg gag gaa cgc agc ggc cac tgc gcc gtg gtg gac gga aac ttc      100
 Val Ala Glu Glu Arg Ser Gly His Cys Ala Val Val Asp Gly Asn Phe
      10                  15                  20

 ctc tac gtg tgg ggg ggc tac gtg tct att gaa gac aat gaa gta tat      148
 Leu Tyr Val Trp Gly Gly Tyr Val Ser Ile Glu Asp Asn Glu Val Tyr
  25                  30                  35                  40

 ttg cct aat gat gaa att tgg acc tat gat att gat agt ggg ttg tgg      196
 Leu Pro Asn Asp Glu Ile Trp Thr Tyr Asp Ile Asp Ser Gly Leu Trp
                  45                  50                  55

 aga atg cac ctc atg gaa gga gaa ctc cca gcc tcc atg tca gga agc      244
 Arg Met His Leu Met Glu Gly Glu Leu Pro Ala Ser Met Ser Gly Ser
              60                  65                  70

 tgt ggt gct tgc att aat gga aag ctg tac att ttt gga gga tat gat      292
 Cys Gly Ala Cys Ile Asn Gly Lys Leu Tyr Ile Phe Gly Gly Tyr Asp
          75                  80                  85

 gac aaa gga tac agc aat cga ctt tat ttt gtt aat tta cga aca aga      340
 Asp Lys Gly Tyr Ser Asn Arg Leu Tyr Phe Val Asn Leu Arg Thr Arg
      90                  95                 100

 gat gaa acc tac att tgg gag aaa atc acc gac ttt gaa ggg caa cca      388
 Asp Glu Thr Tyr Ile Trp Glu Lys Ile Thr Asp Phe Glu Gly Gln Pro
 105                 110                 115                 120

 cct aca cca cgt gat aaa ctt tcc tgc tgg gta tat aaa gac aga cta      436
 Pro Thr Pro Arg Asp Lys Leu Ser Cys Trp Val Tyr Lys Asp Arg Leu
                 125                 130                 135

 ata tat ttt ggt ggt tat ggg tgt agg aga cac agt gaa ctc caa gac      484
 Ile Tyr Phe Gly Gly Tyr Gly Cys Arg Arg His Ser Glu Leu Gln Asp
             140                 145                 150

 tgt ttt gat gtt cat gat gca tct tgg gaa gag cag ata ttc tgg gga      532
 Cys Phe Asp Val His Asp Ala Ser Trp Glu Glu Gln Ile Phe Trp Gly
         155                 160                 165

 tgg cat aat gat gtc cac ata ttt gac aca aag aca cag act tgg ttt      580
 Trp His Asn Asp Val His Ile Phe Asp Thr Lys Thr Gln Thr Trp Phe
     170                 175                 180

 caa cca gaa att aaa ggt gga gtt cca cca cag cca cga gcc gcg cat      628
 Gln Pro Glu Ile Lys Gly Gly Val Pro Pro Gln Pro Arg Ala Ala His
 185                 190                 195                 200

 acg tgt gca gtt ctt gga aat aag ggt tat atc ttt ggc gga cgt gtt      676
 Thr Cys Ala Val Leu Gly Asn Lys Gly Tyr Ile Phe Gly Gly Arg Val
                 205                 210                 215

 ctg caa act agg atg aat gat ttg cac tat cta aac cta gac acc tgg      724
 Leu Gln Thr Arg Met Asn Asp Leu His Tyr Leu Asn Leu Asp Thr Trp
             220                 225                 230

 act tgg tct gga agg att act att aat gga gaa agc cca aaa cat cgg      772
 Thr Trp Ser Gly Arg Ile Thr Ile Asn Gly Glu Ser Pro Lys His Arg
         235                 240                 245

 tca tgg cat act tta aca cct ata gct gat gat aaa ctt ttc cta tgt      820
 Ser Trp His Thr Leu Thr Pro Ile Ala Asp Asp Lys Leu Phe Leu Cys
     250                 255                 260

 ggt gga cta agt gca gat aat atc cca tta agt gat ggt tgg att cat      868
 Gly Gly Leu Ser Ala Asp Asn Ile Pro Leu Ser Asp Gly Trp Ile His
 265                 270                 275                 280

 aat gtc aca aca aat tgt tgg aaa caa ctt aca cat tta cct aaa aca      916
 Asn Val Thr Thr Asn Cys Trp Lys Gln Leu Thr His Leu Pro Lys Thr
                 285                 290                 295

 aga cct agg tta tgg cac aca gcc tgt ttg gga aaa gaa aat gaa ata      964
 Arg Pro Arg Leu Trp His Thr Ala Cys Leu Gly Lys Glu Asn Glu Ile
             300                 305                 310

 atg gta ttt ggt ggg agc aaa gat gac tta ctt gcc ttg gat aca ggt     1012
 Met Val Phe Gly Gly Ser Lys Asp Asp Leu Leu Ala Leu Asp Thr Gly
         315                 320                 325

 cac tgt aat gat tta ttg atc ttt caa aca cag cct tat tca cta ctc     1060
 His Cys Asn Asp Leu Leu Ile Phe Gln Thr Gln Pro Tyr Ser Leu Leu
     330                 335                 340

 agg tca tgc ctt gac tgc att ggt aaa aat tct atc atg tta gaa agt     1108
 Arg Ser Cys Leu Asp Cys Ile Gly Lys Asn Ser Ile Met Leu Glu Ser
 345                 350                 355                 360

 cag ata tct tta tta cct cct aaa ctt ctg caa caa gta ctc aaa aaa     1156
 Gln Ile Ser Leu Leu Pro Pro Lys Leu Leu Gln Gln Val Leu Lys Lys
                 365                 370                 375

 ata aca ttt tgg gct gca gct aat cac cga gaa gaa caa aga gtc caa     1204
 Ile Thr Phe Trp Ala Ala Ala Asn His Arg Glu Glu Gln Arg Val Gln
             380                 385                 390

 aaa gaa gaa aca gaa aat aaa tat cag tgg atc agt agc aat taa att     1252
 Lys Glu Glu Thr Glu Asn Lys Tyr Gln Trp Ile Ser Ser Asn 
         395                 400                 405

 gttatatact ttacatattt agtatgtttt aactttttaa tcagactata catttacact   1312

 cccaaattgc aggctttatt taaaggataa aatttaaagg ataaaaaaac agtcactctg   1372

 ttaagtgact atatgccatg ggatatatgg aaaaaagata ttaatgcaga ttaatttata   1432

 tttgtaaaca aatttcctta caaactgcag aacaaatatt ctttctgaaa gtaagtacag   1492

 ttataacaga ttttaaatca atgtgtattc tttactggaa agattacata catttgagaa   1552

 taagaaatta ctctcaagaa cttcagaaat ctgcaacata attttataaa tatataaata   1612

 catgtatgta tgtcaaaaca ctacatatac actttcagaa agaataaact ttctcaagtc   1672

 attttaaagt tacctaacgt tcttcttgaa taactaatac agtgggtcaa atattataaa   1732

 ataggcaaac accaaaatgg tattaaatat tgaactcctg accttttcga cacttaccta   1792

 gtaaagtatt cttaggcatc atcataactt ttcctcacct ttattcgaat agaggaataa   1852

 atgtcttcag ttgtctctcc attaccccta agttattagt ttgtctagtt tatatataaa   1912

 gaccatgttt taaagtacat aaagtggagg tttatttatc atacaggctt tgaaacatta   1972

 agaagcagta tttttattaa ctttttgaga catattaaaa tacattttgc cttagaagac   2032

 tgcttctaaa gtaatttttg taagtaatga gatgggatgg taatctagta atttgacttt   2092

 atagaaatcc ctcagtttgg cccccaccat tctacagagt tgtactcaag acagatactg   2152

 aaaaaatcta ataccttccc ttgtattttc agcattacca tctatacaga aatggaacac   2212

 tgtatcttta tattcctaaa aatggtactt ttggcataat taagaaattt ttcttcatat   2272

 tatcacaatc atgcccttcc attgaattat taattacaat taattactaa aaagcttggt   2332

 atgtaaaatt attctccaca atattaccat gcaagttatc tctgaaattt aaaatgttaa   2392

 agaaaaacat ttctatattg aaatatatat aatttataat gaaaattata gtagtttgta   2452

 gtatttcatt gaattttaga gagatatttc atatatatgt actgtatttt ggatgtgtaa   2512

 agcttctatg tattgaaata tttttttacg ttttatttat tgtacaaagt gtatataatt   2572

 actgttttct tttttgtcag tgtaaagcag tcattaaaat tgattataca aaaaatattt   2632

 cattggcagg tttcattttt ctatttttag gctgaataac agatttagaa aatgaacctc   2692

 acaaataatt cacatcttgg aaataattac cttattatgc tggggggctg atgaacttta   2752

 gcatcagcct tttatattta aggcaaaaat atatcaaaac ctaattagac actgatagat   2812

 gacattgagc agaaggaaca ccgttttaaa atggcttctg gattatgtga atgccttgtc   2872

 ccc                                                                 2875




      <210> 94
      <211> 871
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (476)..(817)

      <400> 94
 gctacttctt atttcttcta ttaccgaaac tctcttgctt tcactgggct ttcaaggtgt     60

 gagctcttca tgtgaggatt ctctgactgt gattttctcc aaagtgatct caggcagtaa    120

 cttcatttct tttcggggtg ggagtggggg cattggggaa gacaccctca tgtctggcac    180

 acagatgctc cagcagctga gagatcaccc atccacccca caccgcaaaa ctggcaacca    240

 gtgtgctttt gcaaaggctc tgatatttga tcctgatgac ctttattcag gggtcaattt    300

 ctccaaggta ctgagtactc ttttagctgt caacaaagca acagaagatc agctatcaga    360

 aagaccatgt ggacgttcct cttctcttag tgctgctaat acttctcaga caaacccaca    420

 gggagcagtt tctagcacag tttcagggct gcaaaggcag tcaaagacag tggag atg     478
                                                              Met
                                                                1

 acg gaa aat gga agt cat cag ttg ata gta aaa gca aga ttc aac ttt      526
 Thr Glu Asn Gly Ser His Gln Leu Ile Val Lys Ala Arg Phe Asn Phe
               5                  10                  15

 aag cag act aat gag gat gaa ctg tca gtt tgt aag ggg gac atc att      574
 Lys Gln Thr Asn Glu Asp Glu Leu Ser Val Cys Lys Gly Asp Ile Ile
          20                  25                  30

 tac gtc aca cga gtt gaa gaa gga ggc tgg tgg gaa ggc aca tta aat      622
 Tyr Val Thr Arg Val Glu Glu Gly Gly Trp Trp Glu Gly Thr Leu Asn
      35                  40                  45

 ggg aga aca ggc tgg ttc ccc agt aat tat gtc cgt gaa att aaa tcc      670
 Gly Arg Thr Gly Trp Phe Pro Ser Asn Tyr Val Arg Glu Ile Lys Ser
  50                  55                  60                  65

 agt gag aga cct ctc tcc cca aaa gcc gtc aaa gga ttt gaa act gct      718
 Ser Glu Arg Pro Leu Ser Pro Lys Ala Val Lys Gly Phe Glu Thr Ala
                  70                  75                  80

 cca ctt acc aag aat tat tat act gtg tgt tac aga aca tcc tgg aca      766
 Pro Leu Thr Lys Asn Tyr Tyr Thr Val Cys Tyr Arg Thr Ser Trp Thr
              85                  90                  95

 ctg aaa aag aat atg cta aag aac ttc agt ctc ttc ttg tta ctt act      814
 Leu Lys Lys Asn Met Leu Lys Asn Phe Ser Leu Phe Leu Leu Leu Thr
         100                 105                 110

 taa gacc cctgcagtcc aataacaatc tgagtactgt ggaggttaca tctttactgg      871
 






      <210> 95
      <211> 897
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (124)..(843)

      <400> 95
 ccatcccagc tcagtagctt ttcctgggat aactgtgatg aagggaagga ccctgcggtg     60

 atcagaagcc tgactctgga gcctgacccc atcatcgttc ctggaaatgt gaccctcagt    120

 gtc  atg ggc agc acc agt gtc ccc ctg agt tct cct ctg aag gaa ctt     168
      Met Gly Ser Thr Ser Val Pro Leu Ser Ser Pro Leu Lys Glu Leu
        1               5                  10                  15

 cag ggc ttc cac agg ttc aca ggt gta gtg gct gat gga aac ttc agg      216
 Gln Gly Phe His Arg Phe Thr Gly Val Val Ala Asp Gly Asn Phe Arg
                  20                  25                  30

 ttc ctg gtc cgg atc ttc tgg tat tgc tgg ctt gat ccc ttc ccg atg      264
 Phe Leu Val Arg Ile Phe Trp Tyr Cys Trp Leu Asp Pro Phe Pro Met
              35                  40                  45

 cag tcc ctg atg cag gct ccc ctc ctg atc gcc ctg ggc ttg ctt ctc      312
 Gln Ser Leu Met Gln Ala Pro Leu Leu Ile Ala Leu Gly Leu Leu Leu
          50                  55                  60

 gcg gcc cct gcg caa gcc cac ctg aaa aag cca tcc cag ctc agt agc      360
 Ala Ala Pro Ala Gln Ala His Leu Lys Lys Pro Ser Gln Leu Ser Ser
      65                  70                  75

 ttt tcc tgg gat aac tgt gat gaa ggg aag gac cct gcg gtg atc aga      408
 Phe Ser Trp Asp Asn Cys Asp Glu Gly Lys Asp Pro Ala Val Ile Arg
  80                  85                  90                  95

 agc ctg act ctg gag cct gac ccc atc gtc gtt cct gga aat gtg acc      456
 Ser Leu Thr Leu Glu Pro Asp Pro Ile Val Val Pro Gly Asn Val Thr
                 100                 105                 110

 ctc agt gtc gtg ggc agc acc agt gtc ccc ctg agt tct cct ctg aag      504
 Leu Ser Val Val Gly Ser Thr Ser Val Pro Leu Ser Ser Pro Leu Lys
             115                 120                 125

 gtg gat tta gtt ttg gag aag gag gtg gct ggc ctc tgg atc aag atc      552
 Val Asp Leu Val Leu Glu Lys Glu Val Ala Gly Leu Trp Ile Lys Ile
         130                 135                 140

 cca tgc aca gac tac att ggc agc tgt acc ttt gaa cac ttc tgt gat      600
 Pro Cys Thr Asp Tyr Ile Gly Ser Cys Thr Phe Glu His Phe Cys Asp
     145                 150                 155

 gtg ctt gac atg tta att cct act ggg gag ccc tgc cca gag ccc ctg      648
 Val Leu Asp Met Leu Ile Pro Thr Gly Glu Pro Cys Pro Glu Pro Leu
 160                 165                 170                 175

 cgt acc tat ggg ctt cct tgc cac tgt ccc ttc aaa gaa gga acc tac      696
 Arg Thr Tyr Gly Leu Pro Cys His Cys Pro Phe Lys Glu Gly Thr Tyr
                 180                 185                 190

 tca ctg ccc aag agc gaa ttc gtt gtg cct gac ctg gag ctg ccc agt      744
 Ser Leu Pro Lys Ser Glu Phe Val Val Pro Asp Leu Glu Leu Pro Ser
             195                 200                 205

 tgg ctc acc acc ggg aac tac cgc ata gag agc gtc ctg agc agc agt      792
 Trp Leu Thr Thr Gly Asn Tyr Arg Ile Glu Ser Val Leu Ser Ser Ser
         210                 215                 220

 ggg aag cgt ctg ggc tgc atc aag atc gct gcc tct cta aag ggc ata      840
 Gly Lys Arg Leu Gly Cys Ile Lys Ile Ala Ala Ser Leu Lys Gly Ile
     225                 230                 235

 taa catg gcatctgcca cagcagaatg gagcggtgtg aggaaggtcc cttttcctct      897
 






      <210> 96
      <211> 2138
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (103)..(1071)

      <400> 96
 ctgcagagga ggctgccggc agtacaggat gcagggagaa cccaggcctg gggttgaggc     60

 caggagactc aattccagct ttactgtgtg cctttagcag ga   atg tca tgg gta     114
                                                  Met Ser Trp Val
                                                    1

 gaa gct gct ggc gtg tca tct aca gcc ttg gag gac agg att gtg gcc      162
 Glu Ala Ala Gly Val Ser Ser Thr Ala Leu Glu Asp Arg Ile Val Ala
   5                  10                  15                  20

 aag cat gag gag gtt cca gaa gtt tca gtt cag tat gaa gaa aaa ttt      210
 Lys His Glu Glu Val Pro Glu Val Ser Val Gln Tyr Glu Glu Lys Phe
                  25                  30                  35

 cag aac cat cac aaa ctg cca tcc cag ctc agt agc ttt tcc tgg gat      258
 Gln Asn His His Lys Leu Pro Ser Gln Leu Ser Ser Phe Ser Trp Asp
              40                  45                  50

 aac tgt gat gaa ggg aag gac cct gcg gtg atc aga agc ctg act ctg      306
 Asn Cys Asp Glu Gly Lys Asp Pro Ala Val Ile Arg Ser Leu Thr Leu
          55                  60                  65

 gag cct gac ccc atc atc gtt cct gga aat gtg acc ctc agt gtc atg      354
 Glu Pro Asp Pro Ile Ile Val Pro Gly Asn Val Thr Leu Ser Val Met
      70                  75                  80

 ggc agc acc agt gtc ccc ctg agt tct cct ctg aag gaa ctt cag ggc      402
 Gly Ser Thr Ser Val Pro Leu Ser Ser Pro Leu Lys Glu Leu Gln Gly
  85                  90                  95                 100

 ttc cac agg ttc aca ggt gta gtg gct gat gga aac ttc agg ttc ctg      450
 Phe His Arg Phe Thr Gly Val Val Ala Asp Gly Asn Phe Arg Phe Leu
                 105                 110                 115

 gtc cgg atc ttc tgg tat tgc tgg ctt gat ccc ttc ccg atg cag tcc      498
 Val Arg Ile Phe Trp Tyr Cys Trp Leu Asp Pro Phe Pro Met Gln Ser
             120                 125                 130

 ctg atg cag gct ccc ctc ctg atc gcc ctg ggc ttg ctt ctc gcg gcc      546
 Leu Met Gln Ala Pro Leu Leu Ile Ala Leu Gly Leu Leu Leu Ala Ala
         135                 140                 145

 cct gcg caa gcc cac ctg aaa aag cca tcc cag ctc agt agc ttt tcc      594
 Pro Ala Gln Ala His Leu Lys Lys Pro Ser Gln Leu Ser Ser Phe Ser
     150                 155                 160

 tgg gat aac tgt gat gaa ggg aag gac cct gcg gtg atc aga agc ctg      642
 Trp Asp Asn Cys Asp Glu Gly Lys Asp Pro Ala Val Ile Arg Ser Leu
 165                 170                 175                 180

 act ctg gag cct gac ccc atc gtc gtt cct gga aat gtg acc ctc agt      690
 Thr Leu Glu Pro Asp Pro Ile Val Val Pro Gly Asn Val Thr Leu Ser
                 185                 190                 195

 gtc gtg ggc agc acc agt gtc ccc ctg agt tct cct ctg aag gtg gat      738
 Val Val Gly Ser Thr Ser Val Pro Leu Ser Ser Pro Leu Lys Val Asp
             200                 205                 210

 tta gtt ttg gag aag gag gtg gct ggc ctc tgg atc aag atc cca tgc      786
 Leu Val Leu Glu Lys Glu Val Ala Gly Leu Trp Ile Lys Ile Pro Cys
         215                 220                 225

 aca gac tac att ggc agc tgt acc ttt gaa cac ttc tgt gat gtg ctt      834
 Thr Asp Tyr Ile Gly Ser Cys Thr Phe Glu His Phe Cys Asp Val Leu
     230                 235                 240

 gac atg tta att cct act ggg gag ccc tgc cca gag ccc ctg cgt acc      882
 Asp Met Leu Ile Pro Thr Gly Glu Pro Cys Pro Glu Pro Leu Arg Thr
 245                 250                 255                 260

 tat ggg ctt cct tgc cac tgt ccc ttc aaa gaa gga acc tac tca ctg      930
 Tyr Gly Leu Pro Cys His Cys Pro Phe Lys Glu Gly Thr Tyr Ser Leu
                 265                 270                 275

 ccc aag agc gaa ttc gtt gtg cct gac ctg gag ctg ccc agt tgg ctc      978
 Pro Lys Ser Glu Phe Val Val Pro Asp Leu Glu Leu Pro Ser Trp Leu
             280                 285                 290

 acc acc ggg aac tac cgc ata gag agc gtc ctg agc agc agt ggg aag     1026
 Thr Thr Gly Asn Tyr Arg Ile Glu Ser Val Leu Ser Ser Ser Gly Lys
         295                 300                 305

 cgt ctg ggc tgc atc aag atc gct gcc tct cta aag ggc ata taa cat     1074
 Arg Leu Gly Cys Ile Lys Ile Ala Ala Ser Leu Lys Gly Ile 
     310                 315                 320

 ggcatctgcc acagcagaat ggagcggtgt gaggaaggtc ccttttcctc tgttttgtgt   1134

 ttgccaaggc caaactccca ctctctgccc ccctttaatc ccctttctac agtgagtcca   1194

 ctaccctcac tgaaaatcat tttgtaccac ttacatttta ggctggggca agcagccctg   1254

 acctaaggga gaatgagttg gacagttctt gatagcccag ggcatctgct gggctgacca   1314

 cgttactcat ccccgttaac attctctcta aagagcctcg ttcatttcca aagcagttaa   1374

 ggaatgggaa ccagagtgtt ttaggacctg aagaatcttt atgactctct ctctttcact   1434

 cttttttttt tttgtcacta agttaaaagc gaagtgagag tattaacgtt tttgttctcc   1494

 tccggccccc tgttacaatg aaggggcaaa agtatttgct cttagtctat tcctccctta   1554

 acttctgtga ctaattttta tttcctttct agatttgccc aattaatact agggtgcagt   1614

 gtatcctgga gaggtagggt gtgtggggga ggaatccctt gggggagata ttaggagtgc   1674

 tctgttgttt acaaactcag gtacccgcag ggcctagcaa gagacttaaa tgactgataa   1734

 gaaccgtgag aaacatgttg cttccaggct tgatttcgat ttttcgcttt tttttttttt   1794

 gccagacccg cattctcgtt tgtcaccggg gtggaggggg cgggtgaatc tctacctcat   1854

 gggaagctcg cggctcgtgg gtgcagggca ttgctcgtgg ctgagggctc ccaggtaggg   1914

 ggggataaga gggcgggcca cacggcgcgg gtaatagggt tttaggacaa gggggttccc   1974

 ccattgtgcc gcgagggccc gactcttggg gccgagctcg gcccttggtt tgaaaaggcg   2034

 taaaagcaga gcaagaccca gagatttctt ggaaaagggt aacaggaatt tttccaaaga   2094

 cgcatgtctt taaagagggg gggcctgaaa aaaagggggc gcaa                    2138




      <210> 97
      <211> 672
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (415)..(672)

      <400> 97
 ttactgttgg agggcttgaa actttccttc ctttcttttg gcccttgcat gttcaaggat     60

 gccaaggaaa tccgaggaga tgcagctcga tctgtcacat cttctgtctt tgttaaggca    120

 gctctgataa aaggaaggga acaagagacc catgaacaaa taaattacaa catgaaggac    180

 aaatgcaagt atagagaatt ttttgggaga ggttcaagaa taggcacagg ggaagcagaa    240

 gacccatccc ctacattaag caaagcagtc aagcgcttta gcatggccct taacttgtta    300

 tcaggttcca gggatgcttt gttgaaagaa aagaacaaaa caaaacaaga caaaaccaaa    360

 ccaaaccaat accttgacaa aaaacaggcc agctacgctg ctgtcgctgt cact  atg     417
                                                              Met
                                                                1

 gcc cat tac aaa gcc gcc aac ttg aag cgt gag cag ttc cgg agg tac      465
 Ala His Tyr Lys Ala Ala Asn Leu Lys Arg Glu Gln Phe Arg Arg Tyr
               5                  10                  15

 ttg gag aag tca ggg gtg ctg gac aca ctg acc aag gtg ttg cat cac      513
 Leu Glu Lys Ser Gly Val Leu Asp Thr Leu Thr Lys Val Leu His His
          20                  25                  30

 tta gga act gct acc cca gaa aat cca gaa ata gag ctg ctg tgc cta      561
 Leu Gly Thr Ala Thr Pro Glu Asn Pro Glu Ile Glu Leu Leu Cys Leu
      35                  40                  45

 gaa ctg gcg aaa acg aaa gag aaa tat aaa gct att gta gaa aaa aat      609
 Glu Leu Ala Lys Thr Lys Glu Lys Tyr Lys Ala Ile Val Glu Lys Asn
  50                  55                  60                  65

 aaa aaa ctg aaa gca aag ctt gct cag tat gaa cca cct cag gag gag      657
 Lys Lys Leu Lys Ala Lys Leu Ala Gln Tyr Glu Pro Pro Gln Glu Glu
                  70                  75                  80

 aag tat gct gaa tag                                                  672
 Lys Tyr Ala Glu 
              85





      <210> 98
      <211> 1017
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (262)..(1017)

      <400> 98
 atccaacagt gaaagcaaag cacaaaatcc agtaagcctg atgactgtta tgaaattttg     60

 aactgtaacc atctagaaat ataatccaag ctcagagtta ttttgcatcc tccaagactg    120

 caaatgccac gtacagcatg gatcttgtct ttaggcctag gaggctttaa gaagacaggg    180

 gaggaatgag ctccttgcct tcccctgcag tccagtgtcc atgctggcca gcaccagggc    240

 ttcactcacc ctgcttgtgg g  atg gct aga aga gct gac agt ccc ctt gct     291
                          Met Ala Arg Arg Ala Asp Ser Pro Leu Ala
                            1               5                  10

 agt tgt cat cag ctg ata ggg cca aca gga acc att tta aca aaa att      339
 Ser Cys His Gln Leu Ile Gly Pro Thr Gly Thr Ile Leu Thr Lys Ile
                  15                  20                  25

 att cgg tac tta ctg ttg gag ggc ttg aaa cta cgg gaa gaa ccg aag      387
 Ile Arg Tyr Leu Leu Leu Glu Gly Leu Lys Leu Arg Glu Glu Pro Lys
              30                  35                  40

 atg gat tct tct cct gat gcc aag gaa atc cga gga gat gca gct cga      435
 Met Asp Ser Ser Pro Asp Ala Lys Glu Ile Arg Gly Asp Ala Ala Arg
          45                  50                  55

 tct gtc aca tct tct gtc ttt gtt aag gca gct ctg ata aaa gga agg      483
 Ser Val Thr Ser Ser Val Phe Val Lys Ala Ala Leu Ile Lys Gly Arg
      60                  65                  70

 gaa caa gag acc cat gaa caa ata aat tac aac atg aag gac aaa tgc      531
 Glu Gln Glu Thr His Glu Gln Ile Asn Tyr Asn Met Lys Asp Lys Cys
  75                  80                  85                  90

 aag tat aga gaa ttt ttt ggg aga ggt tca aga ata ggc aca ggg gaa      579
 Lys Tyr Arg Glu Phe Phe Gly Arg Gly Ser Arg Ile Gly Thr Gly Glu
                  95                 100                 105

 gca gaa gac cca tcc cct aca tta agc aaa gca gtc aag cgc ttt agc      627
 Ala Glu Asp Pro Ser Pro Thr Leu Ser Lys Ala Val Lys Arg Phe Ser
             110                 115                 120

 atg gcc ctt aac ttg tta tca ggt tcc agg gat gct ttg ttg aaa gaa      675
 Met Ala Leu Asn Leu Leu Ser Gly Ser Arg Asp Ala Leu Leu Lys Glu
         125                 130                 135

 aag aac aaa aca aaa caa gac aaa acc aaa cca aac caa tac ctt gac      723
 Lys Asn Lys Thr Lys Gln Asp Lys Thr Lys Pro Asn Gln Tyr Leu Asp
     140                 145                 150

 aaa aaa cag gcc agc tac gct gct gtc gct gtc act atg gcc cat tac      771
 Lys Lys Gln Ala Ser Tyr Ala Ala Val Ala Val Thr Met Ala His Tyr
 155                 160                 165                 170

 aaa gcc gcc aac ttg aag cgt gag cag ttc cgg agg tac ttg gag aag      819
 Lys Ala Ala Asn Leu Lys Arg Glu Gln Phe Arg Arg Tyr Leu Glu Lys
                 175                 180                 185

 tca ggg gtg ctg gac aca ctg acc aag gtg ttg cat cac tta gga act      867
 Ser Gly Val Leu Asp Thr Leu Thr Lys Val Leu His His Leu Gly Thr
             190                 195                 200

 gct acc cca gaa aat cca gaa ata gag ctg ctg tgc cta gaa ctg gcg      915
 Ala Thr Pro Glu Asn Pro Glu Ile Glu Leu Leu Cys Leu Glu Leu Ala
         205                 210                 215

 aaa acg aaa gag aaa tat aaa gct att gta gaa aaa aat aaa aaa ctg      963
 Lys Thr Lys Glu Lys Tyr Lys Ala Ile Val Glu Lys Asn Lys Lys Leu
     220                 225                 230

 aaa gca aag ctt gct cag tat gaa cca cct cag gag gag aag tat gct     1011
 Lys Ala Lys Leu Ala Gln Tyr Glu Pro Pro Gln Glu Glu Lys Tyr Ala
 235                 240                 245                 250

 gaa tag                                                             1017
 Glu 






      <210> 99
      <211> 417
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(417)

      <400> 99
  atg gcg gtg cga ggg cca ctg cac agc cag cag agc cgt ggt gag gac      48
  Met Ala Val Arg Gly Pro Leu His Ser Gln Gln Ser Arg Gly Glu Asp
    1               5                  10                  15

 ggc agt gcc tgc acg cag ctc tcc gcc tcc cct gcc cgc cag ccc agg       96
 Gly Ser Ala Cys Thr Gln Leu Ser Ala Ser Pro Ala Arg Gln Pro Arg
              20                  25                  30

 cgg ccc cag cag cag cga cca gag gag ccc ccg cag ccg cgc aac ggc      144
 Arg Pro Gln Gln Gln Arg Pro Glu Glu Pro Pro Gln Pro Arg Asn Gly
          35                  40                  45

 cag gga aaa acc ttc gtg aac atc acg cca gct aag gtt ggt gtc ctg      192
 Gln Gly Lys Thr Phe Val Asn Ile Thr Pro Ala Lys Val Gly Val Leu
      50                  55                  60

 gtt ggc aaa gac tgg tca agc ttt ttc gtg aat agg ctg aca ctg cgg      240
 Val Gly Lys Asp Trp Ser Ser Phe Phe Val Asn Arg Leu Thr Leu Arg
  65                  70                  75                  80

 ggc cag aaa tgt act gtg gtc ctg gac tca ctg ctg cag gat ggg gaa      288
 Gly Gln Lys Cys Thr Val Val Leu Asp Ser Leu Leu Gln Asp Gly Glu
                  85                  90                  95

 ctg acc gtg cat ctt caa acg aag agc atc ggt gga gcc ccc acc ttc      336
 Leu Thr Val His Leu Gln Thr Lys Ser Ile Gly Gly Ala Pro Thr Phe
             100                 105                 110

 aat gtc act atc acc atg act gcc aag acg cta ggc ctg ctg atg ggc      384
 Asn Val Thr Ile Thr Met Thr Ala Lys Thr Leu Gly Leu Leu Met Gly
         115                 120                 125

 aaa ggt gtc cac ggc agt ttc acc att tca taa                          417
 Lys Gly Val His Gly Ser Phe Thr Ile Ser 
     130                 135





      <210> 100
      <211> 859
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (24)..(461)

      <400> 100
 cggggagtct caccttgatc gcc    atg gta cat tcc gcc tat tta ggt gac      50
                              Met Val His Ser Ala Tyr Leu Gly Asp
                                1               5

 act ata gaa caa gtt tgt aca aaa aag cag gct ggt acc ggt ccg gaa       98
 Thr Ile Glu Gln Val Cys Thr Lys Lys Gln Ala Gly Thr Gly Pro Glu
  10                  15                  20                  25

 ttc ccg gga tat cgt cga ccc acg cgt ccg ccc acg cgt ccg cag att      146
 Phe Pro Gly Tyr Arg Arg Pro Thr Arg Pro Pro Thr Arg Pro Gln Ile
                  30                  35                  40

 ccc tcc gtc gcc gcc aag atg atg tgc ggg gcg ccc tcc gcc acg cag      194
 Pro Ser Val Ala Ala Lys Met Met Cys Gly Ala Pro Ser Ala Thr Gln
              45                  50                  55

 ccg gcc acc gcc gag acc cag cac atc gcc gac cag gtg agg tcc cag      242
 Pro Ala Thr Ala Glu Thr Gln His Ile Ala Asp Gln Val Arg Ser Gln
          60                  65                  70

 ctt gaa gag aaa gaa aac aag aag ttc cct gtg ttt aag gcc gtg tca      290
 Leu Glu Glu Lys Glu Asn Lys Lys Phe Pro Val Phe Lys Ala Val Ser
      75                  80                  85

 ttc aag agc cag gtg gtc gcg ggg aca aac tac ttc atc aag gtg cac      338
 Phe Lys Ser Gln Val Val Ala Gly Thr Asn Tyr Phe Ile Lys Val His
  90                  95                 100                 105

 gtc ggc gac gag gac ttc gta cac ctg cga gtg ttc caa tct ctc cct      386
 Val Gly Asp Glu Asp Phe Val His Leu Arg Val Phe Gln Ser Leu Pro
                 110                 115                 120

 cat gaa aac aag ccc ttg acc tta tct aac tac cag acc aac aaa gcc      434
 His Glu Asn Lys Pro Leu Thr Leu Ser Asn Tyr Gln Thr Asn Lys Ala
             125                 130                 135

 aag cat gat gag ctg acc tat ttc tga tcctg actttggaca aggcccttca      486
 Lys His Asp Glu Leu Thr Tyr Phe 
         140                 145

 gccagaagac tgacaaagtc atcctccgtc taccagagcg tgcacttgtg atcctaaaat    546

 aagcttcatc tccgggctgt gccccttggg gtggaagggg caggattctg cagctgcttt    606

 tgcatttctc ttcctaaatt tcattgtgtt gatttctttc cttcccaata ggtgatctta    666

 attactttca gaatattttc aaaatagata tatttttaaa atccttacag attgcaaaaa    726

 aaaaaaaaaa gggcggccgc tctagagtat ccctcgaggg gcccaagctt acgcgtaccc    786

 agctttcttg tacaaagtgg tccctatagt gagtcgtata taagctaggg gctacgaccc    846

 tgaagaaaac acc                                                       859




      <210> 101
      <211> 3390
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (145)..(2598)

      <400> 101
 gggcctagaa acttgcttag cacagagtag gtgctcatta aacaagcgat tgagttaata     60

 cttgggtaca gataggtgtg aagcgtgggc atgggtgggg gacactctcg gtttgtttag    120

 tatctcccgg gtttccccgt tctg   atg cgc cct ccc cgt gcc ccc gtc gtg     171
                              Met Arg Pro Pro Arg Ala Pro Val Val
                                1               5

 cct cca gac ctg ggc ggc ccc cgc ctg tgc ccg gtc ccc gcc gcc ggg      219
 Pro Pro Asp Leu Gly Gly Pro Arg Leu Cys Pro Val Pro Ala Ala Gly
  10                  15                  20                  25

 ggc gca cgc agc ccg agc tcg ccc tac tcg gtg gag acg ccc tac ggc      267
 Gly Ala Arg Ser Pro Ser Ser Pro Tyr Ser Val Glu Thr Pro Tyr Gly
                  30                  35                  40

 ttc cac ctg gac ctg gac ttc ctc aag tac ata gag gag ctg gag cgt      315
 Phe His Leu Asp Leu Asp Phe Leu Lys Tyr Ile Glu Glu Leu Glu Arg
              45                  50                  55

 ggc ccc gct gcc cgc cgc gcc ccg gga ccc ccg acc tcg cgc cgt ccc      363
 Gly Pro Ala Ala Arg Arg Ala Pro Gly Pro Pro Thr Ser Arg Arg Pro
          60                  65                  70

 cgc gcg ccc cgg ccc ggc ctc gcg ggc gca cgt agc cca ggc gcc tgg      411
 Arg Ala Pro Arg Pro Gly Leu Ala Gly Ala Arg Ser Pro Gly Ala Trp
      75                  80                  85

 aca tcc agc gag tcc ctg gcc agt gac gac ggt gga gca ccg ggc ata      459
 Thr Ser Ser Glu Ser Leu Ala Ser Asp Asp Gly Gly Ala Pro Gly Ile
  90                  95                 100                 105

 ctc tcc cag ggc gcg ccc tcg ggg ctc ctg atg cag ccg ctg tcg ccg      507
 Leu Ser Gln Gly Ala Pro Ser Gly Leu Leu Met Gln Pro Leu Ser Pro
                 110                 115                 120

 cgc gcg ccc gtg cgc aac ccg cgc gtc gag cac acg ctc cgg gag acc      555
 Arg Ala Pro Val Arg Asn Pro Arg Val Glu His Thr Leu Arg Glu Thr
             125                 130                 135

 agc cgg cgg ctg gag ctg gcg cag aca cac gag cgc gcg ccc agc ccc      603
 Ser Arg Arg Leu Glu Leu Ala Gln Thr His Glu Arg Ala Pro Ser Pro
         140                 145                 150

 ggc cgc ggg gtc ccg cgc agc cca cgc ggg tcc ggc cgc agc agc ccc      651
 Gly Arg Gly Val Pro Arg Ser Pro Arg Gly Ser Gly Arg Ser Ser Pro
     155                 160                 165

 gcc cct aac ctt gcc cct gct tcg ccc ggc cct gcc caa ctg cag ctg      699
 Ala Pro Asn Leu Ala Pro Ala Ser Pro Gly Pro Ala Gln Leu Gln Leu
 170                 175                 180                 185

 gtg cgc gag cag atg gcc gcg gcg ctg cgg cgc ctg cgc gag ctc gag      747
 Val Arg Glu Gln Met Ala Ala Ala Leu Arg Arg Leu Arg Glu Leu Glu
                 190                 195                 200

 gac cag gcg cga acg ctg ccc gag ctg cag gag cag gtg cgc gcg ctg      795
 Asp Gln Ala Arg Thr Leu Pro Glu Leu Gln Glu Gln Val Arg Ala Leu
             205                 210                 215

 cgc gcc gag aag gcg cgg ctg ctg gcc ggg cgc gcg cag ccc gag ccg      843
 Arg Ala Glu Lys Ala Arg Leu Leu Ala Gly Arg Ala Gln Pro Glu Pro
         220                 225                 230

 gac ggg gag gct gag acg cgc ccg gac aag ctc gcc cag ctg cgg cgg      891
 Asp Gly Glu Ala Glu Thr Arg Pro Asp Lys Leu Ala Gln Leu Arg Arg
     235                 240                 245

 ctc acc gag cgc ctg gcc acc tcc gag cgc ggc ggc cgt gcc agg gcc      939
 Leu Thr Glu Arg Leu Ala Thr Ser Glu Arg Gly Gly Arg Ala Arg Ala
 250                 255                 260                 265

 agc ccc cgg gct gac agc cca gac ggc ctg gct gca ggg cgc agc gag      987
 Ser Pro Arg Ala Asp Ser Pro Asp Gly Leu Ala Ala Gly Arg Ser Glu
                 270                 275                 280

 ggc gcg ctc cag gtc ctc gac ggg gag gtc ggg agt ctc gat ggg acg     1035
 Gly Ala Leu Gln Val Leu Asp Gly Glu Val Gly Ser Leu Asp Gly Thr
             285                 290                 295

 ccc cag acc cgg gag gtg gcc gcc gag gcc gtg ccc gag acc cga gaa     1083
 Pro Gln Thr Arg Glu Val Ala Ala Glu Ala Val Pro Glu Thr Arg Glu
         300                 305                 310

 gcg ggt gcc cag gcc gtg ccg gag acc cgg gag gcc ggc gtg gag gct     1131
 Ala Gly Ala Gln Ala Val Pro Glu Thr Arg Glu Ala Gly Val Glu Ala
     315                 320                 325

 gcc ccc gag acc gtg gag gcg gac gcg tgg gtg acc gag gcg ctg ctg     1179
 Ala Pro Glu Thr Val Glu Ala Asp Ala Trp Val Thr Glu Ala Leu Leu
 330                 335                 340                 345

 ggg ctg cct gcg gcc gcc gag cgc gag cta gag ctg ctg cgc gcc agt     1227
 Gly Leu Pro Ala Ala Ala Glu Arg Glu Leu Glu Leu Leu Arg Ala Ser
                 350                 355                 360

 ctg gag cac cag cgc ggg gtg agt gag ctt ctg cgg ggc cgg ttg cgg     1275
 Leu Glu His Gln Arg Gly Val Ser Glu Leu Leu Arg Gly Arg Leu Arg
             365                 370                 375

 gag ctg gag gaa gcc cgc gag gct gcg gag gag gca gcg gcg ggg gcc     1323
 Glu Leu Glu Glu Ala Arg Glu Ala Ala Glu Glu Ala Ala Ala Gly Ala
         380                 385                 390

 cgg gcc cag cta cgc gag gcc acc acc cag acc ccg tgg agc tgt gcc     1371
 Arg Ala Gln Leu Arg Glu Ala Thr Thr Gln Thr Pro Trp Ser Cys Ala
     395                 400                 405

 gaa aag gcc gcg cag acc gag tcc ccg gca gag gcg ccc tcc ttg act     1419
 Glu Lys Ala Ala Gln Thr Glu Ser Pro Ala Glu Ala Pro Ser Leu Thr
 410                 415                 420                 425

 cag gag agc tcg ccc gga tcc atg gac gga gac agg gcc gtg gcg ccc     1467
 Gln Glu Ser Ser Pro Gly Ser Met Asp Gly Asp Arg Ala Val Ala Pro
                 430                 435                 440

 gcg ggc atc ctc aaa tcc atc atg aag aag aga gac ggc aca cct ggt     1515
 Ala Gly Ile Leu Lys Ser Ile Met Lys Lys Arg Asp Gly Thr Pro Gly
             445                 450                 455

 gcc caa ccc agc tcc gga ccc aag agc ctg cag ttt gtt ggg gtc ctc     1563
 Ala Gln Pro Ser Ser Gly Pro Lys Ser Leu Gln Phe Val Gly Val Leu
         460                 465                 470

 aac gga gag tac gag agc tcc tcc agc gag gac gcc agc gac agc gag     1611
 Asn Gly Glu Tyr Glu Ser Ser Ser Ser Glu Asp Ala Ser Asp Ser Glu
     475                 480                 485

 aac ggt ggc gcc gag ccc ccg ggt agc tcc tcg ggc tcc ggg gat gac     1659
 Asn Gly Gly Ala Glu Pro Pro Gly Ser Ser Ser Gly Ser Gly Asp Asp
 490                 495                 500                 505

 agc ggc ggg gga tcc gac tcg ggc acc cct ggc cct ccc agc ggc ggg     1707
 Ser Gly Gly Gly Ser Asp Ser Gly Thr Pro Gly Pro Pro Ser Gly Gly
                 510                 515                 520

 gac atc cgg gac cct gag ccc gag gcg gag gca gag cct cag cag gtg     1755
 Asp Ile Arg Asp Pro Glu Pro Glu Ala Glu Ala Glu Pro Gln Gln Val
             525                 530                 535

 gca cag ggg agg tgc gag ctg agc ccg cgt ctg agg gag gcg tgc gta     1803
 Ala Gln Gly Arg Cys Glu Leu Ser Pro Arg Leu Arg Glu Ala Cys Val
         540                 545                 550

 gcg ctg cag cgg cag ctg agc cgg ccc cgc gga gta gcc agc gac ggc     1851
 Ala Leu Gln Arg Gln Leu Ser Arg Pro Arg Gly Val Ala Ser Asp Gly
     555                 560                 565

 ggc gca gtg cgc ctc gtg gcc cag gag tgg ttt cga gtg tcc agc cag     1899
 Gly Ala Val Arg Leu Val Ala Gln Glu Trp Phe Arg Val Ser Ser Gln
 570                 575                 580                 585

 cgg cgc tct cag gcg gag ccc gtg gcc agg atg ctg gaa ggg gtg agg     1947
 Arg Arg Ser Gln Ala Glu Pro Val Ala Arg Met Leu Glu Gly Val Arg
                 590                 595                 600

 cgc ctg gga ccc gaa ctg ctg gcg cac gtg gtg aac ctg gcg gat ggc     1995
 Arg Leu Gly Pro Glu Leu Leu Ala His Val Val Asn Leu Ala Asp Gly
             605                 610                 615

 aac ggg aac acg gcc ctg cac tac agt gtg tcc cac ggg aac ctg gcc     2043
 Asn Gly Asn Thr Ala Leu His Tyr Ser Val Ser His Gly Asn Leu Ala
         620                 625                 630

 atc gca agc ctg ctc ctg gat acg ggg gcc tgc gag gtc aac cgc cag     2091
 Ile Ala Ser Leu Leu Leu Asp Thr Gly Ala Cys Glu Val Asn Arg Gln
     635                 640                 645

 aac cga gcc ggc tac tcg gcc ctc atg ctg gct gca ctc acc tct gtg     2139
 Asn Arg Ala Gly Tyr Ser Ala Leu Met Leu Ala Ala Leu Thr Ser Val
 650                 655                 660                 665

 agg cag gaa gag gag gac atg gct gtg gtc cag aga ctc ttc tgc atg     2187
 Arg Gln Glu Glu Glu Asp Met Ala Val Val Gln Arg Leu Phe Cys Met
                 670                 675                 680

 ggt gat gtc aat gcc aag gcc agt cag acg ggg cag aca gcc ctc atg     2235
 Gly Asp Val Asn Ala Lys Ala Ser Gln Thr Gly Gln Thr Ala Leu Met
             685                 690                 695

 ctg gcc atc agc cat ggc cga cag gac atg gtg gca acc cta ctg gcg     2283
 Leu Ala Ile Ser His Gly Arg Gln Asp Met Val Ala Thr Leu Leu Ala
         700                 705                 710

 tgt ggg gct gat gtg aat gcg cag gat gcg gat ggg gcc aca gcg ctg     2331
 Cys Gly Ala Asp Val Asn Ala Gln Asp Ala Asp Gly Ala Thr Ala Leu
     715                 720                 725

 atg tgt gcc agt gag tat ggg cgc ctg gac acc gtg cgg ctg ctg ctc     2379
 Met Cys Ala Ser Glu Tyr Gly Arg Leu Asp Thr Val Arg Leu Leu Leu
 730                 735                 740                 745

 acc cag cca ggc tgt gac cct gcc atc ctg gac aat gag ggc acc agt     2427
 Thr Gln Pro Gly Cys Asp Pro Ala Ile Leu Asp Asn Glu Gly Thr Ser
                 750                 755                 760

 gcc ctg gcc atc gcc ctg gag gct gag cag gat gag gtg gcc gct ctg     2475
 Ala Leu Ala Ile Ala Leu Glu Ala Glu Gln Asp Glu Val Ala Ala Leu
             765                 770                 775

 cta cat gcc cac ctg agc tcg ggc cag ccc gac acc cag agc gag tca     2523
 Leu His Ala His Leu Ser Ser Gly Gln Pro Asp Thr Gln Ser Glu Ser
         780                 785                 790

 ccc cct ggc tcc cag aca gcc aca cct ggt gaa gga gaa tgc ggt gac     2571
 Pro Pro Gly Ser Gln Thr Ala Thr Pro Gly Glu Gly Glu Cys Gly Asp
     795                 800                 805

 aat gga gag aac ccc cag gtt cag taa gctgc ctcgtctggc tcactacacc     2623
 Asn Gly Glu Asn Pro Gln Val Gln 
 810                 815

 tagctgtggg gagatctcct cgtcagtcac ctcagccttt ggcgcacaga agggtccagg   2683

 gtcccctgct cagaggctaa cactggccga agagaaaggc aatttcagtt ggggtgactg   2743

 tggcaggaag gggctcactc tggccccacc aaggtgaggt ggggaccaag tgatagagcc   2803

 ctgatccacc cactctctga aacttctttg ctaataaaac attcctacta cgcttgtgtt   2863

 ttgtttgggg tagagggtgc aatcgacaaa cacgaccccc cgcctcaaaa aggaaaagct   2923

 tcgtttggca agaccgcacg gccaggattt ccagagtgcg gaggatcggt gaccgcctgg   2983

 gagccactca agaaacctgg agaaacccta gtcgtataac ccagacaaga acctgagtta   3043

 acttgaaaca caaacgcttt atttaaagga gcatctcagt tacgtgtggc ggacaaaaaa   3103

 aaggagcaga ctgtgacaga ccattcccat cggccaagtg gtcgaacccg acatccaaga   3163

 ccctgtaaac agacccaaac atgagatgtt gacaggcccc gcagcaattg gcaaactccc   3223

 gcctccctct tgtcagtctc tgtatgtaga ctctgcctcc caaaccctct caccctgggc   3283

 ttaacgaagc ctccctacca ccaaccaaag gtctatcaaa ggggtgtcct ctttgcaccc   3343

 accagcgagc agccaagctc agcgcaacct ccgggccctc gtgccaa                 3390




      <210> 102
      <211> 1304
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1254)

      <400> 102
  atg agc ggc cga agt cgg ggt cga aag tcc tcc cgc gcc aaa aac cgg      48
  Met Ser Gly Arg Ser Arg Gly Arg Lys Ser Ser Arg Ala Lys Asn Arg
    1               5                  10                  15

 ggc aaa ggc cgc gcc aaa gcc cga gtc cgc cct gct ccg gac gac gcc       96
 Gly Lys Gly Arg Ala Lys Ala Arg Val Arg Pro Ala Pro Asp Asp Ala
              20                  25                  30

 ccg cgc gac ccg gac cct tca cag tac cag agt ctc ggg gaa gac acc      144
 Pro Arg Asp Pro Asp Pro Ser Gln Tyr Gln Ser Leu Gly Glu Asp Thr
          35                  40                  45

 cag gcg gca cag gtg cag gct ggc gcg ggg tgg ggt ggc ctg gaa gcc      192
 Gln Ala Ala Gln Val Gln Ala Gly Ala Gly Trp Gly Gly Leu Glu Ala
      50                  55                  60

 gct gcg tcc gcg cag ctc ctc cgg ctc ggg gag gag gcc gcc tgc cgg      240
 Ala Ala Ser Ala Gln Leu Leu Arg Leu Gly Glu Glu Ala Ala Cys Arg
  65                  70                  75                  80

 ctc ccc ctg gac tgt ggc ctc gcg ctg cgg gcc cga gct gcg ggg gac      288
 Leu Pro Leu Asp Cys Gly Leu Ala Leu Arg Ala Arg Ala Ala Gly Asp
                  85                  90                  95

 cac ggg cag gcc gcg gcc agg ccc ggc ccg ggg aag gcc gca tct ctc      336
 His Gly Gln Ala Ala Ala Arg Pro Gly Pro Gly Lys Ala Ala Ser Leu
             100                 105                 110

 tcg gag cgc ctg gcc gca gac agt gtc ttc gtg gga aca gcg gga acc      384
 Ser Glu Arg Leu Ala Ala Asp Ser Val Phe Val Gly Thr Ala Gly Thr
         115                 120                 125

 gtg gga agg ccg aaa aat gcc ccc cgc gtt gga aac cgg cgt ggc cct      432
 Val Gly Arg Pro Lys Asn Ala Pro Arg Val Gly Asn Arg Arg Gly Pro
     130                 135                 140

 gcc ggg aag aag gcc cca gaa acc tgt agc acc gcg ggg agg ggg cct      480
 Ala Gly Lys Lys Ala Pro Glu Thr Cys Ser Thr Ala Gly Arg Gly Pro
 145                 150                 155                 160

 cag gtc ata gct ggt ggg agg cag aag aaa ggg gcg gca ggg gag aat      528
 Gln Val Ile Ala Gly Gly Arg Gln Lys Lys Gly Ala Ala Gly Glu Asn
                 165                 170                 175

 acc tcg gtg tca gct ggg gag gaa aag aag gaa gag agg gat gca ggg      576
 Thr Ser Val Ser Ala Gly Glu Glu Lys Lys Glu Glu Arg Asp Ala Gly
             180                 185                 190

 tcg ggg ccc cca gcg acg gaa ggc agc atg gat acg ctg gag aac gtg      624
 Ser Gly Pro Pro Ala Thr Glu Gly Ser Met Asp Thr Leu Glu Asn Val
         195                 200                 205

 cag ctg aag ctg gag aac atg aac gcc cag gcg gac agg gcc tac ctt      672
 Gln Leu Lys Leu Glu Asn Met Asn Ala Gln Ala Asp Arg Ala Tyr Leu
     210                 215                 220

 cgg ctc tcc agg aag ttt ggg cag ttg cga ctg cag cac ttg gag cgc      720
 Arg Leu Ser Arg Lys Phe Gly Gln Leu Arg Leu Gln His Leu Glu Arg
 225                 230                 235                 240

 agg aac cac ctc atc caa aat atc ccg ggc ttc tgg ggg caa gca ttt      768
 Arg Asn His Leu Ile Gln Asn Ile Pro Gly Phe Trp Gly Gln Ala Phe
                 245                 250                 255

 cag aac cat ccc cag cta gca tcc ttt ctg aat agc caa gag aaa gag      816
 Gln Asn His Pro Gln Leu Ala Ser Phe Leu Asn Ser Gln Glu Lys Glu
             260                 265                 270

 gta ctg agc tac tta aac agc ttg gaa gtg gaa gag ctc ggc ctt gcc      864
 Val Leu Ser Tyr Leu Asn Ser Leu Glu Val Glu Glu Leu Gly Leu Ala
         275                 280                 285

 aga ttg ggc tac aaa atc aag ttc tac ttc gat cgc aac ccg tat ttc      912
 Arg Leu Gly Tyr Lys Ile Lys Phe Tyr Phe Asp Arg Asn Pro Tyr Phe
     290                 295                 300

 caa aat aag gtg ctc atc aag gaa tat ggg tgt ggt cct tct ggc cag      960
 Gln Asn Lys Val Leu Ile Lys Glu Tyr Gly Cys Gly Pro Ser Gly Gln
 305                 310                 315                 320

 gtg gtg tct cgt tct act cca atc cag tgg ctc cca ggg cat gat ctc     1008
 Val Val Ser Arg Ser Thr Pro Ile Gln Trp Leu Pro Gly His Asp Leu
                 325                 330                 335

 cag tcc cta agc cag gga aac cca gaa aac aac cgt agt ttc ttt ggg     1056
 Gln Ser Leu Ser Gln Gly Asn Pro Glu Asn Asn Arg Ser Phe Phe Gly
             340                 345                 350

 tgg ttt tca aac cac agc tcc att gag tct gac aag att gtg gag ata     1104
 Trp Phe Ser Asn His Ser Ser Ile Glu Ser Asp Lys Ile Val Glu Ile
         355                 360                 365

 atc aac gaa gaa ttg tgg ccc aat ccc ttg cag ttc tac ctt ttg agt     1152
 Ile Asn Glu Glu Leu Trp Pro Asn Pro Leu Gln Phe Tyr Leu Leu Ser
     370                 375                 380

 gaa ggg gct cgt gta gag aaa gga aag gaa aaa gaa ggc agg caa ggt     1200
 Glu Gly Ala Arg Val Glu Lys Gly Lys Glu Lys Glu Gly Arg Gln Gly
 385                 390                 395                 400

 cca gga aag cag cca atg gag act act cag cct ggg gtg agc caa tcc     1248
 Pro Gly Lys Gln Pro Met Glu Thr Thr Gln Pro Gly Val Ser Gln Ser
                 405                 410                 415

 aac tga tcctgcacaa gtctccctgc tacctcctgc tgggctgctc ctggttgact      1304
 Asn 






      <210> 103
      <211> 852
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(852)

      <400> 103
  atg aat cta aat ggc aga tgg cag gga gtg ata agt gga tgt ttc caa      48
  Met Asn Leu Asn Gly Arg Trp Gln Gly Val Ile Ser Gly Cys Phe Gln
    1               5                  10                  15

 gga ttg tct tca gtc atg gcc ttg gga tta aag tgc ttc cgc atg gtc       96
 Gly Leu Ser Ser Val Met Ala Leu Gly Leu Lys Cys Phe Arg Met Val
              20                  25                  30

 cac cct acc ttt cgc aat tat ctt gca gcc tct atc aga ccc gtt tca      144
 His Pro Thr Phe Arg Asn Tyr Leu Ala Ala Ser Ile Arg Pro Val Ser
          35                  40                  45

 gaa gtt aca ctg aag aca gtg cat gaa aga caa cat ggc cat agg caa      192
 Glu Val Thr Leu Lys Thr Val His Glu Arg Gln His Gly His Arg Gln
      50                  55                  60

 tac atg gcc tat tca gct gta cca gtc cgc cat ttt gct acc aag aaa      240
 Tyr Met Ala Tyr Ser Ala Val Pro Val Arg His Phe Ala Thr Lys Lys
  65                  70                  75                  80

 gcc aaa gcc aaa ggg aaa gga cag tcc caa acc aga gtg aat att aat      288
 Ala Lys Ala Lys Gly Lys Gly Gln Ser Gln Thr Arg Val Asn Ile Asn
                  85                  90                  95

 gct gcc ttg gtt gag gat ata atc aac ttg gaa gag gtg aat gaa gaa      336
 Ala Ala Leu Val Glu Asp Ile Ile Asn Leu Glu Glu Val Asn Glu Glu
             100                 105                 110

 atg aag tct gtg ata gaa gct ctc aag gat aat ttc aat aag act ctc      384
 Met Lys Ser Val Ile Glu Ala Leu Lys Asp Asn Phe Asn Lys Thr Leu
         115                 120                 125

 aat ata agg acc tca cca gga tcc ctt gac aag att gct gtg gta act      432
 Asn Ile Arg Thr Ser Pro Gly Ser Leu Asp Lys Ile Ala Val Val Thr
     130                 135                 140

 gct gac ggg aag ctt gct tta aac cag att agc cag atc tcc atg aag      480
 Ala Asp Gly Lys Leu Ala Leu Asn Gln Ile Ser Gln Ile Ser Met Lys
 145                 150                 155                 160

 tcg cca cag ctg att ttg gtg aat atg gcc agc ttc cca gag tgt aca      528
 Ser Pro Gln Leu Ile Leu Val Asn Met Ala Ser Phe Pro Glu Cys Thr
                 165                 170                 175

 gct gca gct atc aag gct ata aga gaa agt gga atg aat ctg aac cca      576
 Ala Ala Ala Ile Lys Ala Ile Arg Glu Ser Gly Met Asn Leu Asn Pro
             180                 185                 190

 gaa gtg gaa ggg acg cta att cgg gta ccc att ccc caa gta acc aga      624
 Glu Val Glu Gly Thr Leu Ile Arg Val Pro Ile Pro Gln Val Thr Arg
         195                 200                 205

 gag cac aga gaa atg ctg gtg aaa ctg gcc aaa cag aac acc aac aag      672
 Glu His Arg Glu Met Leu Val Lys Leu Ala Lys Gln Asn Thr Asn Lys
     210                 215                 220

 gcc aaa gac tct tta cgg aag gtt cgc acc aac tca atg aac aag ctg      720
 Ala Lys Asp Ser Leu Arg Lys Val Arg Thr Asn Ser Met Asn Lys Leu
 225                 230                 235                 240

 aag aaa tcc aag gat aca gtc tca gag gac acc att agg cta ata gag      768
 Lys Lys Ser Lys Asp Thr Val Ser Glu Asp Thr Ile Arg Leu Ile Glu
                 245                 250                 255

 aaa cag atc agc caa atg gcc gat gac aca gtg gca gaa ctg gac agg      816
 Lys Gln Ile Ser Gln Met Ala Asp Asp Thr Val Ala Glu Leu Asp Arg
             260                 265                 270

 cat ctg gca gtg aag acc aaa gaa ctc ctt gga tga                      852
 His Leu Ala Val Lys Thr Lys Glu Leu Leu Gly 
         275                 280





      <210> 104
      <211> 926
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (33)..(872)

      <400> 104
 ggaattcccg ggtcgacgat ttcgtcggga ag  atg gcg gcc tcc agg aat ggg      53
                                      Met Ala Ala Ser Arg Asn Gly
                                        1               5

 ttt gaa gcc gtg gag gca gag ggc agc gca ggg tgc cgg gga agc tcg      101
 Phe Glu Ala Val Glu Ala Glu Gly Ser Ala Gly Cys Arg Gly Ser Ser
          10                  15                  20

 gga atg gag gtg gtg ctt cct ttg gat cct gcc gtc ccc gcc ccg ctg      149
 Gly Met Glu Val Val Leu Pro Leu Asp Pro Ala Val Pro Ala Pro Leu
      25                  30                  35

 tgc cct cac gga ccc act ctt ctg ttt gta aag gtg acc caa ggg aaa      197
 Cys Pro His Gly Pro Thr Leu Leu Phe Val Lys Val Thr Gln Gly Lys
  40                  45                  50                  55

 gaa gaa act cgg agg ttt tat gcc tgt tca gcc tgt aga gat aga aaa      245
 Glu Glu Thr Arg Arg Phe Tyr Ala Cys Ser Ala Cys Arg Asp Arg Lys
                  60                  65                  70

 gac tgt aat ttt ttt cag tgg gaa gat gaa aag ttg tca gga gct aga      293
 Asp Cys Asn Phe Phe Gln Trp Glu Asp Glu Lys Leu Ser Gly Ala Arg
              75                  80                  85

 ctt gct gcc cga gaa gct cat aac cga aga tgt cag cct ccc ctg tcc      341
 Leu Ala Ala Arg Glu Ala His Asn Arg Arg Cys Gln Pro Pro Leu Ser
          90                  95                 100

 cga acg cag tgt gtg gaa agg tac ttg aag ttt att gag ttg ccc ttg      389
 Arg Thr Gln Cys Val Glu Arg Tyr Leu Lys Phe Ile Glu Leu Pro Leu
     105                 110                 115

 act cag aga aag ttt tgt caa aca tgt cag cag ttg ttg tta cca gat      437
 Thr Gln Arg Lys Phe Cys Gln Thr Cys Gln Gln Leu Leu Leu Pro Asp
 120                 125                 130                 135

 gac tgg ggg caa cat agt gag cat cag gtt ctg ggt aat gtg tcc att      485
 Asp Trp Gly Gln His Ser Glu His Gln Val Leu Gly Asn Val Ser Ile
                 140                 145                 150

 acc cag tta aga agg ccc agt caa ctc ctt tat cca ctg gaa aac aag      533
 Thr Gln Leu Arg Arg Pro Ser Gln Leu Leu Tyr Pro Leu Glu Asn Lys
             155                 160                 165

 aag aca aat gcc cag tat ctg ttt gct gat cgg agc tgt cag ttc ttg      581
 Lys Thr Asn Ala Gln Tyr Leu Phe Ala Asp Arg Ser Cys Gln Phe Leu
         170                 175                 180

 gta gac tta ctt tct gcc ctc gga ttc aga aga gta ctg tgt gtt gga      629
 Val Asp Leu Leu Ser Ala Leu Gly Phe Arg Arg Val Leu Cys Val Gly
     185                 190                 195

 aca cca agg ttg cat gag ctg atc aag ttg aca gca tca ggt gac aag      677
 Thr Pro Arg Leu His Glu Leu Ile Lys Leu Thr Ala Ser Gly Asp Lys
 200                 205                 210                 215

 aag tct aac att aaa agc ctt tta ttg gat att gat ttt cgg tat tca      725
 Lys Ser Asn Ile Lys Ser Leu Leu Leu Asp Ile Asp Phe Arg Tyr Ser
                 220                 225                 230

 cag ttt tat atg gaa gat agc ttt tgc cat tat aat atg ttt aac cat      773
 Gln Phe Tyr Met Glu Asp Ser Phe Cys His Tyr Asn Met Phe Asn His
             235                 240                 245

 cat ttc ttt gat gga aag gta aga gct gtg acc att atc tca ttg ttc      821
 His Phe Phe Asp Gly Lys Val Arg Ala Val Thr Ile Ile Ser Leu Phe
         250                 255                 260

 tct tat tgt gga ata aca gat ttc aga gtg cct cct ttg ttc ttt ttc      869
 Ser Tyr Cys Gly Ile Thr Asp Phe Arg Val Pro Pro Leu Phe Phe Phe
     265                 270                 275

 taa attc cctcaaggtc aaattgtggc tgttctacca tttactgata tttatttttg      926
 






      <210> 105
      <211> 2164
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (19)..(1482)

      <400> 105
 taggtgaaac tatagaac  atg ttg tac aaa aag cag gct ggt acc ggt ccg      51
                      Met Leu Tyr Lys Lys Gln Ala Gly Thr Gly Pro
                        1               5                  10

 gaa ttc ccg gga tct gtg aag cag gca ggt tgc tca gct gcc ccc gga       99
 Glu Phe Pro Gly Ser Val Lys Gln Ala Gly Cys Ser Ala Ala Pro Gly
              15                  20                  25

 gcg gtt cct cca cct gag gca gac tcc acg tcg gct ggc atg agc cgg      147
 Ala Val Pro Pro Pro Glu Ala Asp Ser Thr Ser Ala Gly Met Ser Arg
          30                  35                  40

 cgc ccc tgc agc tgc gcc cta cgg cca ccc cgc tgc tcc tgc agc gcc      195
 Arg Pro Cys Ser Cys Ala Leu Arg Pro Pro Arg Cys Ser Cys Ser Ala
      45                  50                  55

 agc ccc agc gca gtg aca gcc gcc ggg cgc cct cga ccc tcg gat agt      243
 Ser Pro Ser Ala Val Thr Ala Ala Gly Arg Pro Arg Pro Ser Asp Ser
  60                  65                  70                  75

 tgt aaa gaa gaa agt tct acc ctt tct gtc aaa atg aag tgt gat ttt      291
 Cys Lys Glu Glu Ser Ser Thr Leu Ser Val Lys Met Lys Cys Asp Phe
                  80                  85                  90

 aat tgt aac cat gtt cat tcc gga ctt aaa ctg gta aaa cct gat gac      339
 Asn Cys Asn His Val His Ser Gly Leu Lys Leu Val Lys Pro Asp Asp
              95                 100                 105

 att gga aga cta gtt tcc tac acc cct gca tat ttg gaa ggt tcc tgt      387
 Ile Gly Arg Leu Val Ser Tyr Thr Pro Ala Tyr Leu Glu Gly Ser Cys
         110                 115                 120

 aaa gac tgc att aaa gac tat gaa agg ctg tca tgt att ggg tca ccg      435
 Lys Asp Cys Ile Lys Asp Tyr Glu Arg Leu Ser Cys Ile Gly Ser Pro
     125                 130                 135

 att gtg agc cct agg att gta gaa ctt gaa act gaa agc aag cgc ttg      483
 Ile Val Ser Pro Arg Ile Val Glu Leu Glu Thr Glu Ser Lys Arg Leu
 140                 145                 150                 155

 cat aac aag gaa aat caa cat gtg caa cag aca ctt aat agt aca aat      531
 His Asn Lys Glu Asn Gln His Val Gln Gln Thr Leu Asn Ser Thr Asn
                 160                 165                 170

 gaa ata gaa gca cta gag acc agt aga ctt tat gaa gac agt ggc tat      579
 Glu Ile Glu Ala Leu Glu Thr Ser Arg Leu Tyr Glu Asp Ser Gly Tyr
             175                 180                 185

 tcc tca ttt tct cta caa agt ggc ctc agt gaa cat gaa gaa ggt agc      627
 Ser Ser Phe Ser Leu Gln Ser Gly Leu Ser Glu His Glu Glu Gly Ser
         190                 195                 200

 ctc ctg gag gag aat ttc ggt gac agt cta caa tcc tgc ctg cta caa      675
 Leu Leu Glu Glu Asn Phe Gly Asp Ser Leu Gln Ser Cys Leu Leu Gln
     205                 210                 215

 ata caa agc cca gac caa tat ccc aac aaa aac ttg ctg cca gtt ctt      723
 Ile Gln Ser Pro Asp Gln Tyr Pro Asn Lys Asn Leu Leu Pro Val Leu
 220                 225                 230                 235

 cat ttt gaa aaa gtg gtt tgt tca aca tta aaa aag aat gca aaa cga      771
 His Phe Glu Lys Val Val Cys Ser Thr Leu Lys Lys Asn Ala Lys Arg
                 240                 245                 250

 aat cct aaa gta gat cgg gag atg ctg aag gaa att ata gcc aga gga      819
 Asn Pro Lys Val Asp Arg Glu Met Leu Lys Glu Ile Ile Ala Arg Gly
             255                 260                 265

 aat ttt aga ctg cag aat ata att ggc aga aaa atg ggc cta gaa tgt      867
 Asn Phe Arg Leu Gln Asn Ile Ile Gly Arg Lys Met Gly Leu Glu Cys
         270                 275                 280

 gta gat att ctc agc gaa ctc ttt cga agg gga ctc aga cat gtc tta      915
 Val Asp Ile Leu Ser Glu Leu Phe Arg Arg Gly Leu Arg His Val Leu
     285                 290                 295

 gca act att tta gca caa ctc agt gac atg gac tta atc aat gtg tct      963
 Ala Thr Ile Leu Ala Gln Leu Ser Asp Met Asp Leu Ile Asn Val Ser
 300                 305                 310                 315

 aaa gtg agc aca act tgg aag aag atc cta gaa gat gat aag ggg gca     1011
 Lys Val Ser Thr Thr Trp Lys Lys Ile Leu Glu Asp Asp Lys Gly Ala
                 320                 325                 330

 ttc cag ttg tac agt aaa gca ata caa aga gtt acc gaa aac aac aat     1059
 Phe Gln Leu Tyr Ser Lys Ala Ile Gln Arg Val Thr Glu Asn Asn Asn
             335                 340                 345

 aaa ttt tca cct cat gct tca acc aga gaa tat gtt atg ttc aga acc     1107
 Lys Phe Ser Pro His Ala Ser Thr Arg Glu Tyr Val Met Phe Arg Thr
         350                 355                 360

 cca ctg gct tct gtt cag aaa tca gca gcc cag act tct ctc aaa aaa     1155
 Pro Leu Ala Ser Val Gln Lys Ser Ala Ala Gln Thr Ser Leu Lys Lys
     365                 370                 375

 gat gct caa acc aag tta tcc aat caa ggt gat cag aaa ggt tct act     1203
 Asp Ala Gln Thr Lys Leu Ser Asn Gln Gly Asp Gln Lys Gly Ser Thr
 380                 385                 390                 395

 tat agt cga cac aat gaa ttc tct gag gtt gcc aag aca ttg aaa aag     1251
 Tyr Ser Arg His Asn Glu Phe Ser Glu Val Ala Lys Thr Leu Lys Lys
                 400                 405                 410

 aac gaa agc ctc aaa gcc tgt att cgc tgt aat tca cct gca aaa tat     1299
 Asn Glu Ser Leu Lys Ala Cys Ile Arg Cys Asn Ser Pro Ala Lys Tyr
             415                 420                 425

 gat tgc tat tta caa cgg gca acc tgc aaa cga gaa ggc tgt gga ttt     1347
 Asp Cys Tyr Leu Gln Arg Ala Thr Cys Lys Arg Glu Gly Cys Gly Phe
         430                 435                 440

 gat tat tgt acg aag tgt ctc tgt aat tat cat act act aaa gac tgt     1395
 Asp Tyr Cys Thr Lys Cys Leu Cys Asn Tyr His Thr Thr Lys Asp Cys
     445                 450                 455

 tca gat ggc aag ctc ctc aaa gcc agt tgt aaa ata ggt ccc ctg cct     1443
 Ser Asp Gly Lys Leu Leu Lys Ala Ser Cys Lys Ile Gly Pro Leu Pro
 460                 465                 470                 475

 ggt aca aag aaa agc aaa aag aat tta cga aga ttg tga tctcttatta      1492
 Gly Thr Lys Lys Ser Lys Lys Asn Leu Arg Arg Leu 
                 480                 485

 aatcaattgt tactgatcat gaatgttagt tagaaaatgt taggttttaa cttaaaaaaa   1552

 attgtattgt gattttcaat tttatgttga aatcggtgta gtatcctgag gtttttttcc   1612

 ccccagaaga taaagaggat agacaacctc ttaaaatatt tttacaattt aatgagaaaa   1672

 agtttaaaat tctcaataca aatcaaacaa tttaaatatt ttaagaaaaa aggaaaagta   1732

 gatagtgata ctgagggtaa aaaaaaattg attcaatttt atggtaaagg aaacccatgc   1792

 aattttacct agacagtctt aaatatgtct ggttttccat ctgttagcat ttcagacatt   1852

 ttatgttcct cttactcaat tgataccaac agaaatatca acttctggag tctattaaat   1912

 gtgttgtcac ctttctaaag ctttttttca ttgtgtgtat ttcccaagaa agtatccttt   1972

 gtaaaaactt gcttgttttc cttatttctg aaatctgttt taatattttt gtatacatgt   2032

 aaatatttct gtatttttta tatgtcaaag aatatgtctc ttgtatgtac atataaaaat   2092

 aaattttgct caataaaatt gtaagcttaa tgtaaaaaaa aaaaaaaaaa aacctatgcg   2152

 gccgcaagct ta                                                       2164




      <210> 106
      <211> 1711
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (55)..(765)

      <400> 106
 cgagcaactg aatgccgcag accgggcggg gggaccgggc ccccggaggg gccg  atg      57
                                                              Met
                                                                1

 ctg agc agg gtg acc agc gga cgt gcg cgg cgc gct aca gcg atc cgg      105
 Leu Ser Arg Val Thr Ser Gly Arg Ala Arg Arg Ala Thr Ala Ile Arg
               5                  10                  15

 ctg gtg aac tgc ctg gag cga ccc aac tta ttc ctg ttg cag ctg ata      153
 Leu Val Asn Cys Leu Glu Arg Pro Asn Leu Phe Leu Leu Gln Leu Ile
          20                  25                  30

 gcg cct tta gcc agg ctg acg acc tac ttg aac agt atc acg gag cgc      201
 Ala Pro Leu Ala Arg Leu Thr Thr Tyr Leu Asn Ser Ile Thr Glu Arg
      35                  40                  45

 ggc gcc ctg gac gag ccg ctg gcg cgc cgc ttc ttc gcg cag gtg ctg      249
 Gly Ala Leu Asp Glu Pro Leu Ala Arg Arg Phe Phe Ala Gln Val Leu
  50                  55                  60                  65

 gcc gcc gtg cgc cac tgc cac agc tgc ggg gtc gtg cac cgc gac att      297
 Ala Ala Val Arg His Cys His Ser Cys Gly Val Val His Arg Asp Ile
                  70                  75                  80

 aag gac gaa aat ctg ctt gtg gac ctg cgc tcc gga gag ctc aag ctc      345
 Lys Asp Glu Asn Leu Leu Val Asp Leu Arg Ser Gly Glu Leu Lys Leu
              85                  90                  95

 atc gac ttc ggt tcg ggt gcg ctg ctc aag gac acg gtc tac acc gac      393
 Ile Asp Phe Gly Ser Gly Ala Leu Leu Lys Asp Thr Val Tyr Thr Asp
         100                 105                 110

 ttc gac ggc acc cga gtg tac agc ccc ccg gag tgg atc cgc tac cac      441
 Phe Asp Gly Thr Arg Val Tyr Ser Pro Pro Glu Trp Ile Arg Tyr His
     115                 120                 125

 cgc tac cac ggg cgc tcg gcc acc gtg tgg tcg ctg ggc gtg ctt ctc      489
 Arg Tyr His Gly Arg Ser Ala Thr Val Trp Ser Leu Gly Val Leu Leu
 130                 135                 140                 145

 tac gat atg gtg tgt ggg gac atc ccc ttc gag cag gac gag gag atc      537
 Tyr Asp Met Val Cys Gly Asp Ile Pro Phe Glu Gln Asp Glu Glu Ile
                 150                 155                 160

 ctc cga ggc cgc ctg ctc ttc cgg agg agg gtc tct cca gag tgc cag      585
 Leu Arg Gly Arg Leu Leu Phe Arg Arg Arg Val Ser Pro Glu Cys Gln
             165                 170                 175

 cag ctg atc cgg tgg tgc ctg tcc ctg cgg ccc tca gag cgg ccg tcg      633
 Gln Leu Ile Arg Trp Cys Leu Ser Leu Arg Pro Ser Glu Arg Pro Ser
         180                 185                 190

 ctg gat cag att gcg gcc cat ccc tgg atg ctg ggg gct gac ggg ggc      681
 Leu Asp Gln Ile Ala Ala His Pro Trp Met Leu Gly Ala Asp Gly Gly
     195                 200                 205

 gcc ccg gag agc tgt gac ctg cgg ctg tgc acc ctc gac cct gat gac      729
 Ala Pro Glu Ser Cys Asp Leu Arg Leu Cys Thr Leu Asp Pro Asp Asp
 210                 215                 220                 225

 gtg gcc agc acc acg tcc agc agc gag agc ttg tga ggag ctgcacctga      779
 Val Ala Ser Thr Thr Ser Ser Ser Glu Ser Leu 
                 230                 235

 ctgggagcta ggggaccacc tgccttggcc agacctggga cgcccccaga ccctgacttt    839

 ttcctgcgtg ggccgtctcc tcctgcggaa gcagtgacct ctgacccctg gtgaccttcg    899

 ctttgagtgc cttttgaacg ctggtcccgc gggacttggt tttctcaagc tctgtctgtc    959

 caaagacgct ccggtcgagg tcccgcctgc cctgggtgga tacttgaacc ccagacgccc   1019

 ctctgtgctg ctgtgtccgg aggcggcctt cccatctgcc tgcccacccg gagctctttc   1079

 cgccggcgca gggtcccaag cccacctccc gccctcagtc ctgcggtgtg cgtctgggca   1139

 cgtcctgcac acacaatgca agtcctggcc tccgcgcccg cccgcccacg cgagccgtac   1199

 ccgccgccaa ctctgttatt tatggtgtga ccccctggag gtgccctcgg cccaccgggg   1259

 ctatttattg tttaatttat ttgttgaggt tatttcctct gagcagtctg cctctcccaa   1319

 gccccagggg acagtgggga ggcaggggag ggggtggctg tggtccaggg accccaggcc   1379

 ctgattcctg tgcctggcgt ctgtcctggc cccgcctgtc agaagatgaa catgtatagt   1439

 ggctaactta aggggagtgg gtgaccctga cacttccagg cactgtgccc agggtttggg   1499

 ttttaaatta ttgactttgt acagtctgct tgtgggctct gaaagctggg gtggggccag   1559

 agcctgagcg tttaatttat tcagtacctg tgtttgtgtg aatgcggtgt gtgcaggcat   1619

 cgcagatggg ggttctttca gttcaaaagt gagatgtctg gagatcatat ttttttatac   1679

 aggtatttca attaaaatgt ttttgtacat ag                                 1711




      <210> 107
      <211> 2353
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1142)..(2353)

      <400> 107
 ccccttttaa aagcaccgtt ttaacctccc agttctggaa aatggttacc gggtatctct     60

 atttaaggga aaaaaaatta aataaaacac tttgggtttt cccaaaaaaa aaaaaaataa    120

 aaagaaagaa aattattgat gtagtggatt ctttgttttt ttctttgtta cttccaaagg    180

 cttatctgtc attaaagggg tatctttccc tttagtattg agaatttgta cgaaattata    240

 aacttttcag aagacagtgt ggcttacttg actctgactt tactttctcc tcaagtggaa    300

 aaagaaaact agagtatttt tttaaataag aatataatgt attattgtgt tcttcaggta    360

 tctaaaacag caccaactgg agaatatttg acaacaggaa gcttcatgat aagaggtaat    420

 gtcttgacag gaaaaatatc actagacttg tcaatggatt atggagacag gtttgagaca    480

 gtttacaaat actcttagaa caaaaacaaa ttactcggat ttcctatgtg aagtctgcta    540

 tgaagtaaag aaatttttgc cttggtgtga caagtttaga ggttggcata tcttcttcat    600

 gtatattttt attgagggca gtgcactttc acatagttta gttataaggg taagaaagga    660

 tagcctgaac ttatttctga aaatagaata ttcagggtct gactgaccca gaatatcaga    720

 gcaagtgtgt atatttttta cttcttaata actgttccta tacatactgc ccagttctat    780

 aaatgggaaa tgttattctt gacatagtaa aagacaaaat ggatatgacc attagtgtca    840

 tctgacacta attttttttt gttttacaag caaaaaatgg agaagactga ttttcaaagc    900

 attaatgtac gttatctttt gtaggaaaaa agaattttct tcctccctca tatctaatga    960

 tggggtttag cttccttttt aaggtactct tcaacttctt ggttatttat ttgttttttt   1020

 cctgattttc attagtcttg tctgaagctc cgtcactgaa aaataactgt ttctttaggt   1080

 agatgagtct tgtgtttgga gacatcaggg tgaacgaaaa gtcagagtac aggatgaaga   1140

 c    atg gag aca ctg gca agt tgt aca agt gaa ctc ata tca gaa gaa    1186
      Met Glu Thr Leu Ala Ser Cys Thr Ser Glu Leu Ile Ser Glu Glu
        1               5                  10                  15

 atg gaa caa tta gat gga ggt gac acg agc agt gat gag gat aaa gaa     1234
 Met Glu Gln Leu Asp Gly Gly Asp Thr Ser Ser Asp Glu Asp Lys Glu
                  20                  25                  30

 gaa cat gaa act cct gtg gaa gta gaa ctc atg act cag gtt gac caa     1282
 Glu His Glu Thr Pro Val Glu Val Glu Leu Met Thr Gln Val Asp Gln
              35                  40                  45

 gag gat atc act ctt cag agt ggc aga gat gaa cta aat gag gag ctc     1330
 Glu Asp Ile Thr Leu Gln Ser Gly Arg Asp Glu Leu Asn Glu Glu Leu
          50                  55                  60

 att cag caa gaa agc tct gaa gac gaa gga gaa tat gaa gag gtt aga     1378
 Ile Gln Gln Glu Ser Ser Glu Asp Glu Gly Glu Tyr Glu Glu Val Arg
      65                  70                  75

 aaa gat cag gat tct gtt ggt gaa atg aag gat gaa ggg gaa gag aca     1426
 Lys Asp Gln Asp Ser Val Gly Glu Met Lys Asp Glu Gly Glu Glu Thr
  80                  85                  90                  95

 tta aat tat cct gat act acc att gac ttg tct cac ctt caa ccc caa     1474
 Leu Asn Tyr Pro Asp Thr Thr Ile Asp Leu Ser His Leu Gln Pro Gln
                 100                 105                 110

 agg tcc atc cag aaa ttg gct tca aaa gag gaa tct tct aat tct agt     1522
 Arg Ser Ile Gln Lys Leu Ala Ser Lys Glu Glu Ser Ser Asn Ser Ser
             115                 120                 125

 gac agt aaa tca cag agc cgg aga cat ttg tca gcc aag gaa aga agg     1570
 Asp Ser Lys Ser Gln Ser Arg Arg His Leu Ser Ala Lys Glu Arg Arg
         130                 135                 140

 gaa atg aaa aag aaa aaa ctt cca agt gac tca gga gat tta gaa gcg     1618
 Glu Met Lys Lys Lys Lys Leu Pro Ser Asp Ser Gly Asp Leu Glu Ala
     145                 150                 155

 tta gag gga aag gat aaa gaa aaa gaa agt act gta cac att gaa act     1666
 Leu Glu Gly Lys Asp Lys Glu Lys Glu Ser Thr Val His Ile Glu Thr
 160                 165                 170                 175

 cat cag aac aca agc aaa aat gtt gcg gct gtg cag cca atg aaa cga     1714
 His Gln Asn Thr Ser Lys Asn Val Ala Ala Val Gln Pro Met Lys Arg
                 180                 185                 190

 gga caa aag agt aaa atg aaa aaa atg aaa gaa aaa tac aaa gac cag     1762
 Gly Gln Lys Ser Lys Met Lys Lys Met Lys Glu Lys Tyr Lys Asp Gln
             195                 200                 205

 gat gaa gaa gac cgt gaa ctt atc atg aag ttg ctg ggg tct gca ggt     1810
 Asp Glu Glu Asp Arg Glu Leu Ile Met Lys Leu Leu Gly Ser Ala Gly
         210                 215                 220

 tca aac aaa gaa gaa aaa ggg aag aag ggg aag aaa gga aaa aca aag     1858
 Ser Asn Lys Glu Glu Lys Gly Lys Lys Gly Lys Lys Gly Lys Thr Lys
     225                 230                 235

 gac gaa cct gtg aag aaa cag ccc cag aaa cct aga ggt gga cag agg     1906
 Asp Glu Pro Val Lys Lys Gln Pro Gln Lys Pro Arg Gly Gly Gln Arg
 240                 245                 250                 255

 gtc tct gac aac att aag aaa gaa act ccg ttc ctt gag gtt ata act     1954
 Val Ser Asp Asn Ile Lys Lys Glu Thr Pro Phe Leu Glu Val Ile Thr
                 260                 265                 270

 cat gag tta caa gac ttt gct gta gat gat cca cat gat gac aag gaa     2002
 His Glu Leu Gln Asp Phe Ala Val Asp Asp Pro His Asp Asp Lys Glu
             275                 280                 285

 gag caa gat ctg gat caa cag gga aat gag gaa aac cta ttt gat tct     2050
 Glu Gln Asp Leu Asp Gln Gln Gly Asn Glu Glu Asn Leu Phe Asp Ser
         290                 295                 300

 ttg aca ggc cag cca cat cct gaa gat gta cta ctg ttt gcc att cca     2098
 Leu Thr Gly Gln Pro His Pro Glu Asp Val Leu Leu Phe Ala Ile Pro
     305                 310                 315

 ata tgt gcc cct tac acc acc atg aca aac tac aaa tat aaa gtg aaa     2146
 Ile Cys Ala Pro Tyr Thr Thr Met Thr Asn Tyr Lys Tyr Lys Val Lys
 320                 325                 330                 335

 ctt act cct gga gtg cag aaa aag gga aaa gct gca aaa aca gcc ttg     2194
 Leu Thr Pro Gly Val Gln Lys Lys Gly Lys Ala Ala Lys Thr Ala Leu
                 340                 345                 350

 aat agt ttc atg cat tcc aaa gaa gca aca gca aga gaa aaa gac tta     2242
 Asn Ser Phe Met His Ser Lys Glu Ala Thr Ala Arg Glu Lys Asp Leu
             355                 360                 365

 ttc cgc agc gta aag gac aca gat tta tca aga aac att cct ggc aaa     2290
 Phe Arg Ser Val Lys Asp Thr Asp Leu Ser Arg Asn Ile Pro Gly Lys
         370                 375                 380

 gtg aaa agt gtc tgc acc caa tct tct gaa cgt aaa aag gaa ata gct     2338
 Val Lys Ser Val Cys Thr Gln Ser Ser Glu Arg Lys Lys Glu Ile Ala
     385                 390                 395

 gaa atg aaa ttc taa                                                 2353
 Glu Met Lys Phe 
 400





      <210> 108
      <211> 1518
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1518)

      <400> 108
  atg gaa gct gag gac atc cag gag gag ttg acc tgc ccc atc tgc ctg      48
  Met Glu Ala Glu Asp Ile Gln Glu Glu Leu Thr Cys Pro Ile Cys Leu
    1               5                  10                  15

 gac tat ttc cag gac ccg gtg tcc atc gag tgc ggc cac aac ttc tgc       96
 Asp Tyr Phe Gln Asp Pro Val Ser Ile Glu Cys Gly His Asn Phe Cys
              20                  25                  30

 cgc ggc tgc ctg cac cgc aac tgg gcg ccg ggc ggc ggc ccg ttc ccc      144
 Arg Gly Cys Leu His Arg Asn Trp Ala Pro Gly Gly Gly Pro Phe Pro
          35                  40                  45

 tgc ccc gaa tgt cgg cac cca tcg gcg ccc gcc gcg ctg cga ccc aac      192
 Cys Pro Glu Cys Arg His Pro Ser Ala Pro Ala Ala Leu Arg Pro Asn
      50                  55                  60

 tgg gcc ctg gcc agg ctg act gag aag acg cag cgc cgg cgc ctg ggc      240
 Trp Ala Leu Ala Arg Leu Thr Glu Lys Thr Gln Arg Arg Arg Leu Gly
  65                  70                  75                  80

 ccc gtg ccc ccg ggc ctg tgc ggc cgc cac tgg gag ccg ctg cgg ctc      288
 Pro Val Pro Pro Gly Leu Cys Gly Arg His Trp Glu Pro Leu Arg Leu
                  85                  90                  95

 ttc tgc gag gac gac cag cgg cca gtg tgc ctg gtg tgc agg gag tcc      336
 Phe Cys Glu Asp Asp Gln Arg Pro Val Cys Leu Val Cys Arg Glu Ser
             100                 105                 110

 cag gag cac cag act cac gcc atg gac tgg gag ccg ctg cgg ctc ttc      384
 Gln Glu His Gln Thr His Ala Met Asp Trp Glu Pro Leu Arg Leu Phe
         115                 120                 125

 tgc gag gac gac cag cgg cca gtg tgc ctg gtg tgc agg gag tcc cag      432
 Cys Glu Asp Asp Gln Arg Pro Val Cys Leu Val Cys Arg Glu Ser Gln
     130                 135                 140

 gag cac cag act cac gcc atg gca ccc atc gac gag gcc ttc gag agc      480
 Glu His Gln Thr His Ala Met Ala Pro Ile Asp Glu Ala Phe Glu Ser
 145                 150                 155                 160

 tac cgg gag aaa ctt ctt aag tct cag cgt aat ctc gtg gcc aag atg      528
 Tyr Arg Glu Lys Leu Leu Lys Ser Gln Arg Asn Leu Val Ala Lys Met
                 165                 170                 175

 aag aaa gtc atg cat tta cag gat gta gaa gtg aag aac gcc aca cag      576
 Lys Lys Val Met His Leu Gln Asp Val Glu Val Lys Asn Ala Thr Gln
             180                 185                 190

 tgg aag gat aag ata aag agt cag cga atg aga atc agc acg gag ttt      624
 Trp Lys Asp Lys Ile Lys Ser Gln Arg Met Arg Ile Ser Thr Glu Phe
         195                 200                 205

 tca aag ctg cac aac ttc ctg gtt gaa gaa gag gac ctg ttt ctt cag      672
 Ser Lys Leu His Asn Phe Leu Val Glu Glu Glu Asp Leu Phe Leu Gln
     210                 215                 220

 aga ttg aac aaa gaa gaa gaa gag acg aag aag aag ctg aat gag aac      720
 Arg Leu Asn Lys Glu Glu Glu Glu Thr Lys Lys Lys Leu Asn Glu Asn
 225                 230                 235                 240

 acg tta aaa ctc aat caa act atc gct tca ttg aag aag ctc atc tta      768
 Thr Leu Lys Leu Asn Gln Thr Ile Ala Ser Leu Lys Lys Leu Ile Leu
                 245                 250                 255

 gag gtg ggg gag aag agc cag gct ccc acc ctg gag ctg ctt cag aat      816
 Glu Val Gly Glu Lys Ser Gln Ala Pro Thr Leu Glu Leu Leu Gln Asn
             260                 265                 270

 cca aaa gaa gtg ttg acc agg agt gag atc cag gat gtg aac tat tcc      864
 Pro Lys Glu Val Leu Thr Arg Ser Glu Ile Gln Asp Val Asn Tyr Ser
         275                 280                 285

 ctt gaa gct gtg aag gtg aag aca gtg tgc cag ata cca ttg atg aag      912
 Leu Glu Ala Val Lys Val Lys Thr Val Cys Gln Ile Pro Leu Met Lys
     290                 295                 300

 gaa atg cta aag cga ttc caa gtg gct gta aac cta gct gaa gac aca      960
 Glu Met Leu Lys Arg Phe Gln Val Ala Val Asn Leu Ala Glu Asp Thr
 305                 310                 315                 320

 gct cat ccc aaa ctc gtc ttc tcc cag gaa ggg aga tac gtg aaa aat     1008
 Ala His Pro Lys Leu Val Phe Ser Gln Glu Gly Arg Tyr Val Lys Asn
                 325                 330                 335

 aca gca tca gcc agt tct tgg cca gtg ttt tct tca gca tgg aac tac     1056
 Thr Ala Ser Ala Ser Ser Trp Pro Val Phe Ser Ser Ala Trp Asn Tyr
             340                 345                 350

 ttt gct gga tgg agg aat cct cag aag act gct ttt gta gag aga ttt     1104
 Phe Ala Gly Trp Arg Asn Pro Gln Lys Thr Ala Phe Val Glu Arg Phe
         355                 360                 365

 cag cac tta ccc tgt gtt ctg gga aaa aac gtt ttc acc tca ggg aaa     1152
 Gln His Leu Pro Cys Val Leu Gly Lys Asn Val Phe Thr Ser Gly Lys
     370                 375                 380

 cat tac tgg gaa gtt gag agt aga gat agt ctg gag gtt gct gtt ggg     1200
 His Tyr Trp Glu Val Glu Ser Arg Asp Ser Leu Glu Val Ala Val Gly
 385                 390                 395                 400

 gtg tgt cgg gag gac gtc atg gga att act gat cgt tca aaa atg tcc     1248
 Val Cys Arg Glu Asp Val Met Gly Ile Thr Asp Arg Ser Lys Met Ser
                 405                 410                 415

 cca gat gtg ggc atc tgg gcg att tat tgg agt gct gct ggc tat tgg     1296
 Pro Asp Val Gly Ile Trp Ala Ile Tyr Trp Ser Ala Ala Gly Tyr Trp
             420                 425                 430

 ccc ttg ata ggc ttc cct gga act ccc acc cag caa gag cca gct ctc     1344
 Pro Leu Ile Gly Phe Pro Gly Thr Pro Thr Gln Gln Glu Pro Ala Leu
         435                 440                 445

 cac cga gtg ggg gtt tac ctg gat cgt ggg act ggg aat gtc tcc ttc     1392
 His Arg Val Gly Val Tyr Leu Asp Arg Gly Thr Gly Asn Val Ser Phe
     450                 455                 460

 tac agc gct gtg gac gga gtg cac ctg cac acc ttt tct tgt tct tct     1440
 Tyr Ser Ala Val Asp Gly Val His Leu His Thr Phe Ser Cys Ser Ser
 465                 470                 475                 480

 gtc tca cgc ctc cgg cca ttt ttt tgg ttg agt cca tta gca tct tta     1488
 Val Ser Arg Leu Arg Pro Phe Phe Trp Leu Ser Pro Leu Ala Ser Leu
                 485                 490                 495

 gtc att cca cca gtg act gat agg aaa tga                             1518
 Val Ile Pro Pro Val Thr Asp Arg Lys 
             500                 505





      <210> 109
      <211> 2495
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (476)..(943)

      <400> 109
 gccttttcct ctcccaggtg cgcttccctg cttgatctgt gtaccctgct ctttctcctt     60

 cattccgcag cctcctttgc cctgtgacct gcaggtactg gacggtccct agagaggata    120

 ccgggacgct cctgaagccg cgagatgatt tcaagcagat gcagcctgac cattagggcc    180

 aaggccaaat tgcaaaaaaa aaaaaaagtt ggcctttatt ctactccatc cacatctaaa    240

 ctttggaggt caaggctggg gacagatcaa aaaacatagt tccctccttc tggggctcca    300

 catccttcat tcactgatct ctggaaagga ggatgggtgg caggatgggt cttccatgat    360

 actgaaggga gagccacatg ttgatgccca ggaccagctg cctccttggt ctgaaaggcc    420

 tgatcgaggc caggattggc tatgaaagct gggaaagggg accatctttg aagcc atg     478
                                                              Met
                                                                1

 gga gag gag cca cca tca ctc atg ttc ttg aat ggg aac tgc ctg gag      526
 Gly Glu Glu Pro Pro Ser Leu Met Phe Leu Asn Gly Asn Cys Leu Glu
               5                  10                  15

 acc ctg aag aag aag gag cct gaa gga gga agg agg agg ctg agc cat      574
 Thr Leu Lys Lys Lys Glu Pro Glu Gly Gly Arg Arg Arg Leu Ser His
          20                  25                  30

 ccc ggg aac atg ggc tgg atg agg cca agc cag gag acg aca cca cca      622
 Pro Gly Asn Met Gly Trp Met Arg Pro Ser Gln Glu Thr Thr Pro Pro
      35                  40                  45

 gat aga agt cac cat tca gga ttt gga ctt ttc tgt gga gat cct ggc      670
 Asp Arg Ser His His Ser Gly Phe Gly Leu Phe Cys Gly Asp Pro Gly
  50                  55                  60                  65

 ccc gag atc gaa ccc ttc tcc ctg tgg gtg ttc ccg cag gag atg gtg      718
 Pro Glu Ile Glu Pro Phe Ser Leu Trp Val Phe Pro Gln Glu Met Val
                  70                  75                  80

 ctg gag atc cac cag ctg ttc atg gac cat gaa tac cca tgt cac cac      766
 Leu Glu Ile His Gln Leu Phe Met Asp His Glu Tyr Pro Cys His His
              85                  90                  95

 atc act tct cac tgc acc tgg gtg gca gca cac tgg acc acg tct cag      814
 Ile Thr Ser His Cys Thr Trp Val Ala Ala His Trp Thr Thr Ser Gln
         100                 105                 110

 agc tgc gca gca tgg cag ggc tgc agg cgg gct tgc tgc tcc acg tgg      862
 Ser Cys Ala Ala Trp Gln Gly Cys Arg Arg Ala Cys Cys Ser Thr Trp
     115                 120                 125

 tgg aag agc cct gca caa tgc aca agg ccc acg gtg atg agt gcc aca      910
 Trp Lys Ser Pro Ala Gln Cys Thr Arg Pro Thr Val Met Ser Ala Thr
 130                 135                 140                 145

 ttt gag act gct cag gag cct gga ccc agc tga tgcagctc cttgtccttc      961
 Phe Glu Thr Ala Gln Glu Pro Gly Pro Ser 
                 150                 155

 ctgagcgtct tcactgacag tggcctgaga gacggcagga gcagaaagac ttggagatgg   1021

 accccaccga ctgcacacca cccaagtaca tcctgctagg gaccctggaa cagccactgt   1081

 gtcccctgca accccagaac ggtgactaaa agcccctgaa agtgctcacc gtgagcggct   1141

 ggtacctgtc ccctgggaac tgcaagatgc acaggacctt gtgtacctgt ttgtgatcac   1201

 agccgaggac cagcgaggta gcattaccac atccacacag ggcttttacc ataactgccc   1261

 cagtactgga acgaggagct gcagatgatg agggacctac ccaacaagaa ccaacctgag   1321

 cagctgcttc aagaaaaagc catgttcaag gtgcctgaat cccctggtaa gtgagtgaca   1381

 gcctcacagc ctcaggccca cctggctcct gctggaaggt tttcttgtgc tcgggagaga   1441

 agtgagggaa gccggcagtc ccagccctgt caggtgccct gaaggcccgt caggtttgcc   1501

 ctgcaaggcc ttctagcatt ctgcttcctg ggagaccatc ccccaccttt ctccggcctc   1561

 tgagactttg agtccttggg aggagaaggc cctccttgct atctgggctg agtggccagg   1621

 gccatccagc ttcccaccct ccactgactg ccatggggcc ctcccctgag cacatggtgc   1681

 ccaactgtag cccttctagg gcaggggctc attggcagca cttgcagctt gctggcactt   1741

 aaaagtcatt agtgcggtta ctgagagaaa tgaggaaaaa ataattgtta aaaaaaaaaa   1801

 aaaatctctc ctaaacttac tgggtaacat ggaaaaagta acagccaaaa tttcttgggt   1861

 actaacttta ccaggatgat tccaagggct ttataagcat tatttcctat aatcttttgg   1921

 accccttgaa aatgtcaata ctttccatca tcatcgttgc ataaacaaaa aactgggtct   1981

 gaagttacct gccctggttt gcctggcaca tagctggtgg atcccaaacc tgccgcagcc   2041

 ctcatactcc ttggtagcca ctaaactctg tgcctcttta agcataagtg tttacttttt   2101

 tgtagaaatg attttcttgc ccttctctaa atataaggaa actgaggcaa gggtctctgg   2161

 ctcccaaggc aggcctggtt gcctctccca tcttggcgag ctggaccagg tggatgtagc   2221

 ctgaggcttt tgtgggcatg gcctctcacc ctcccagcct tggtccctcc caggtacaca   2281

 gcaacttcag aatggcagcc acatggggcg ccatggtagt cagggaggca tcgtcatggc   2341

 catcagtccc agtgaggaga ccaagctgca gatgttcatg tggagccgca tcatcttcag   2401

 cctgggcttt gtcattagtg gccactacaa ggactttgcc atgggtgtgg catcctcgtg   2461

 acgttcgcga ggatctgaac ggtgacaccc gcct                               2495




      <210> 110
      <211> 1012
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (474)..(962)

      <400> 110
 ctattgagtg cccatgtgag gttttttgag cttgtgcatg tctgtgattt tgaatacagc     60

 tttgcactga aataacagca gctcctggct gccttacctg tcactgggtt agacatacac    120

 acatggggat ccttgcgaaa ggatctgttt gacttgcctt tatttctttc ataaaacaag    180

 atcagcagtc ccacctatgc acacattcca cttgtttggc tgggtttctc atgcccagaa    240

 ttctctacca tctataaata cgctctttct ttttttccta ttttttgttt gtttgtttgt    300

 ttgttttttc tccctttcct ttctggcctt accgatgagt tcctcatttg gaaaacggac    360

 agtgcaagag cagcagacga tgactcagaa tgctgggagg ggctgtgtca aatacaggat    420

 gcccaggaga agctagaatt ggacaggtgg gctctctgat ttaaagtaag tac   atg     476
                                                              Met
                                                                1

 aga aag tta agg cca caa ttc atg gat agt gaa atc tgt atc cac aat      524
 Arg Lys Leu Arg Pro Gln Phe Met Asp Ser Glu Ile Cys Ile His Asn
               5                  10                  15

 tca ttt tca tca agt cag aaa gtt atc aaa ctg gaa ttc tgc act ttt      572
 Ser Phe Ser Ser Ser Gln Lys Val Ile Lys Leu Glu Phe Cys Thr Phe
          20                  25                  30

 gtt atg gca tca agc ttc caa agc aac aca gta ata gtc ata cac ttc      620
 Val Met Ala Ser Ser Phe Gln Ser Asn Thr Val Ile Val Ile His Phe
      35                  40                  45

 aac aac cac caa cac tgt gtc aga tgt cca ctc ttc aag tat gaa act      668
 Asn Asn His Gln His Cys Val Arg Cys Pro Leu Phe Lys Tyr Glu Thr
  50                  55                  60                  65

 tgt gca gta gca tgg ctt cta cct ggt ggc aag aac tta gta atc aac      716
 Cys Ala Val Ala Trp Leu Leu Pro Gly Gly Lys Asn Leu Val Ile Asn
                  70                  75                  80

 att act gat acc cct gtc act act gat atc tgg agg gcc tat ttc ttc      764
 Ile Thr Asp Thr Pro Val Thr Thr Asp Ile Trp Arg Ala Tyr Phe Phe
              85                  90                  95

 aga att att ctc cag aga aaa cac ttt caa act cac act gag gtg caa      812
 Arg Ile Ile Leu Gln Arg Lys His Phe Gln Thr His Thr Glu Val Gln
         100                 105                 110

 gtg atg tgt cct cac gta aca gag caa act aaa aac tca act gaa ata      860
 Val Met Cys Pro His Val Thr Glu Gln Thr Lys Asn Ser Thr Glu Ile
     115                 120                 125

 gag tat tca ttt agt att tat ggt cag gag gat ggc gta aag atc act      908
 Glu Tyr Ser Phe Ser Ile Tyr Gly Gln Glu Asp Gly Val Lys Ile Thr
 130                 135                 140                 145

 cca tct tgt gga tcc cat cct tgc tat gcc acg tgg atc gaa tgt cat      956
 Pro Ser Cys Gly Ser His Pro Cys Tyr Ala Thr Trp Ile Glu Cys His
                 150                 155                 160

 gtt taa aaagtggtca agtctactct ttagttcttc aaaagcaagg acacagcagg      1012
 Val 






      <210> 111
      <211> 2782
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (182)..(1399)

      <400> 111
 ccctcaaaat ccaccaatca gtttgcactt ttgggtgagg gtccacctcc aaggctgtcg     60

 ctccggttcc tctgcctcct ctggctgctg cctccgcagc tccctcctcc taccccacct    120

 cctccatctg gggagcgtct gcgggggcct gaggggcggc agcggcggcg gcggctgcga    180

 t    atg gag cca ggg gcc ggc ggc cga aat act gct cgt gcg cag agg     226
      Met Glu Pro Gly Ala Gly Gly Arg Asn Thr Ala Arg Ala Gln Arg
        1               5                  10                  15

 gcc ggg tcc ccg aac act ccg ccg ccc cgg gag cag gag cgg aaa ctg      274
 Ala Gly Ser Pro Asn Thr Pro Pro Pro Arg Glu Gln Glu Arg Lys Leu
                  20                  25                  30

 gag cag gag aag ctc tcc ggt gtg gtg aag agc gtc cac cgg cgg ctc      322
 Glu Gln Glu Lys Leu Ser Gly Val Val Lys Ser Val His Arg Arg Leu
              35                  40                  45

 cgc aag aag tac cga gaa gtg gga gat ttt gat aag atc tgg cga gaa      370
 Arg Lys Lys Tyr Arg Glu Val Gly Asp Phe Asp Lys Ile Trp Arg Glu
          50                  55                  60

 cac tgt gag gat gaa gaa act ctt tgt gaa tat gcc gtt gca atg aaa      418
 His Cys Glu Asp Glu Glu Thr Leu Cys Glu Tyr Ala Val Ala Met Lys
      65                  70                  75

 aat ttg gca gat aat cat tgg gca aaa act tgt gag ggc gaa ggt cgt      466
 Asn Leu Ala Asp Asn His Trp Ala Lys Thr Cys Glu Gly Glu Gly Arg
  80                  85                  90                  95

 att gaa tgg tgt tgt agt gta tgc aga gaa tat ttc caa aat ggt ggg      514
 Ile Glu Trp Cys Cys Ser Val Cys Arg Glu Tyr Phe Gln Asn Gly Gly
                 100                 105                 110

 aag aga aaa gca ctt gag aaa gat gaa aaa aga gct gta ctt gcc act      562
 Lys Arg Lys Ala Leu Glu Lys Asp Glu Lys Arg Ala Val Leu Ala Thr
             115                 120                 125

 aag acc act cca gcc tta aat atg cat gag tct tct caa ctt gaa ggt      610
 Lys Thr Thr Pro Ala Leu Asn Met His Glu Ser Ser Gln Leu Glu Gly
         130                 135                 140

 cat tta acc aac ctc agc ttt aca aac cct gaa ttt ata ctg agt ttg      658
 His Leu Thr Asn Leu Ser Phe Thr Asn Pro Glu Phe Ile Leu Ser Leu
     145                 150                 155

 cta caa gcc tca gga aaa atc aga tta ctt gat gtt ggc agc tgc ttt      706
 Leu Gln Ala Ser Gly Lys Ile Arg Leu Leu Asp Val Gly Ser Cys Phe
 160                 165                 170                 175

 aac cca ttt ctg aag ttt gaa gaa ttt cta act gtt ggc ata gat att      754
 Asn Pro Phe Leu Lys Phe Glu Glu Phe Leu Thr Val Gly Ile Asp Ile
                 180                 185                 190

 gta cct gct gta gag agt gtc tat aaa tgt gat ttc ctg aac tta cag      802
 Val Pro Ala Val Glu Ser Val Tyr Lys Cys Asp Phe Leu Asn Leu Gln
             195                 200                 205

 ctt cag caa cca ctc cag ctt gca cag gat gct ata gat gct ttt ttg      850
 Leu Gln Gln Pro Leu Gln Leu Ala Gln Asp Ala Ile Asp Ala Phe Leu
         210                 215                 220

 aag cag ctg aaa aac cct att gat tct ctt cct gga gag ctt ttc cat      898
 Lys Gln Leu Lys Asn Pro Ile Asp Ser Leu Pro Gly Glu Leu Phe His
     225                 230                 235

 gtg gtt gtt ttc tct ctc ctt ctt tct tat ttt cca tct cct tac cag      946
 Val Val Val Phe Ser Leu Leu Leu Ser Tyr Phe Pro Ser Pro Tyr Gln
 240                 245                 250                 255

 cga tgg att tgc tgc aag aaa gcc cat gaa ctg tta gtg tta aat ggt      994
 Arg Trp Ile Cys Cys Lys Lys Ala His Glu Leu Leu Val Leu Asn Gly
                 260                 265                 270

 tta tta cta atc atc aca cct gat tcc tcc cat cag aac cgt cat gct     1042
 Leu Leu Leu Ile Ile Thr Pro Asp Ser Ser His Gln Asn Arg His Ala
             275                 280                 285

 atg atg atg aaa agc tgg aag att gct ata gag tcc ctg ggc ttt aaa     1090
 Met Met Met Lys Ser Trp Lys Ile Ala Ile Glu Ser Leu Gly Phe Lys
         290                 295                 300

 cgc ttc aag tac tca aaa ttt tca cat atg cat ctg atg gca ttt agg     1138
 Arg Phe Lys Tyr Ser Lys Phe Ser His Met His Leu Met Ala Phe Arg
     305                 310                 315

 aaa atc tct cta aaa acc aca agt gac ttg gtt agt agg aac tac cca     1186
 Lys Ile Ser Leu Lys Thr Thr Ser Asp Leu Val Ser Arg Asn Tyr Pro
 320                 325                 330                 335

 gga atg tta tat att cct caa gat ttc aac agt ata gaa gat gag gaa     1234
 Gly Met Leu Tyr Ile Pro Gln Asp Phe Asn Ser Ile Glu Asp Glu Glu
                 340                 345                 350

 tat tct aac cct tcc tgc tat gtt cga tca gat ata gaa gat gaa caa     1282
 Tyr Ser Asn Pro Ser Cys Tyr Val Arg Ser Asp Ile Glu Asp Glu Gln
             355                 360                 365

 cta gca tat ggt ttc aca gaa ctc cct gat gcg cca tat gac tca gat     1330
 Leu Ala Tyr Gly Phe Thr Glu Leu Pro Asp Ala Pro Tyr Asp Ser Asp
         370                 375                 380

 tct gga gaa agt caa gcc agc tct att cct ttc tat gag cta gaa gac     1378
 Ser Gly Glu Ser Gln Ala Ser Ser Ile Pro Phe Tyr Glu Leu Glu Asp
     385                 390                 395

 ccc ata tta ctt tta agt taa ta tagaagcaaa aagccccttt cagtccaggc     1431
 Pro Ile Leu Leu Leu Ser 
 400                 405

 tcctaaacta attgcttaca ccaattggaa atactaacat gaactcagta ctgaaaacct   1491

 ggtttgcata aaagaaatgc agaggtttac agagtttgct atttttttct acttctcaat   1551

 tttaaaattt attcttatat agaaagctta aagtttcatg cagagtgact catgtcatag   1611

 cagaaactac tgttacttta gcatttagca ctatcataga aaggtacctt tttctcttta   1671

 gtgctattgt gaaaacaagc ataatttgct atatgttttc cttttcaact tttcagtgtt   1731

 gactataaac cattgaatgg aaaactttaa gatgtagaaa gctgtagatt gcactttgat   1791

 gactcacaag ttaaatgtga tacagaaaaa tagatcggtt agttgttttg tgatgcactt   1851

 atctttttct tttttctaac taaaattgtg atgttacaga aagtcatttt atgttccttt   1911

 tttgtctgat gatccaatat ttactgaact ttttgtaatt ggtgataatt ctttttattt   1971

 cttccttata ttaaaagctc atttgacagc atcaaacatt gggggagaga tgtcccccaa   2031

 agtgtgtatt ctaattttat tagccctatc caataaacac cattgccaaa gtagtatttt   2091

 cataactttc ttgttgattt gggccttggt gtgaagtata tttacctgag agttcacttt   2151

 tacttttctt aaacttaggc ttcatttaca aaatgtttta tttaagcaag gaacaatgta   2211

 atactcaata atgacctaaa acaccttttg aaagggtttg cacttggaag agagtttatg   2271

 ttctgttgaa accaactttg atagggtcct cacctttccg ttaaggaggt gccgcactac   2331

 aagtttcaaa ttatatggaa aaacctaaaa ttaaccctct gttggtgatc tcataaaaat   2391

 ggtttgaact ttggtatctt aatttctatc taaactttat cagaaaattt tctttgaata   2451

 tatccattag ttggctggtg ggaattttcc ctttccacat taataaatgc cgttcggggt   2511

 tccggaatca ggaagcaaga gattagggga cacaatatgg tccaaccaga ccgctttgct   2571

 tcaaccggct agaaccttag tccccttgtg tggttaaccg ccatgcggag caacactaaa   2631

 ggccgcggtg gcgtcttcac gggtcactaa aaccaagagg tcggagaaat cacgagaaag   2691

 ggagtaggag tgcttcaaca gccaagacac atagcacaat gaagctggtg acgagcgaga   2751

 aaaacatcag acggccaccg aacgcttcat t                                  2782




      <210> 112
      <211> 1143
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (164)..(1093)

      <400> 112
 ccgcttcgtc cgcgtcagcc tggtcccccg gcttccccat ctccgggctg ggagggaggc     60

 gggaccggcc gcgtctccat ggcgacgcgg gacgcggcgg tggaggcggt tgctacccac    120

 ctgctagagg cgctgcgggt gtgatccagg ctggggcgag acc  atg tcg gac ctg     175
                                                  Met Ser Asp Leu
                                                    1

 ggc tcg gag gag ttg gag gag gag gga gag aat gat att ggg gaa tat      223
 Gly Ser Glu Glu Leu Glu Glu Glu Gly Glu Asn Asp Ile Gly Glu Tyr
   5                  10                  15                  20

 gag ggg ggt cgg aat gag gca ggc gaa agg cac gga cgt ggg agg gca      271
 Glu Gly Gly Arg Asn Glu Ala Gly Glu Arg His Gly Arg Gly Arg Ala
                  25                  30                  35

 cgg cta ccc aac ggg gac acc tac gaa ggg agc tac gaa ttc ggt aaa      319
 Arg Leu Pro Asn Gly Asp Thr Tyr Glu Gly Ser Tyr Glu Phe Gly Lys
              40                  45                  50

 aga cat ggc cag ggg atc tac aaa ttt aaa aat ggt gct cga tat atc      367
 Arg His Gly Gln Gly Ile Tyr Lys Phe Lys Asn Gly Ala Arg Tyr Ile
          55                  60                  65

 gga gaa tat gtt aga aat aaa aag cac ggt caa ggc act ttt ata tat      415
 Gly Glu Tyr Val Arg Asn Lys Lys His Gly Gln Gly Thr Phe Ile Tyr
      70                  75                  80

 cca gat gga tcc aga tat gaa gga gag tgg gca aat gac ctg cgg cac      463
 Pro Asp Gly Ser Arg Tyr Glu Gly Glu Trp Ala Asn Asp Leu Arg His
  85                  90                  95                 100

 ggc cat ggc gta tac tac tac atc aat aat gac acc tac act gga gag      511
 Gly His Gly Val Tyr Tyr Tyr Ile Asn Asn Asp Thr Tyr Thr Gly Glu
                 105                 110                 115

 tgg ttt gct cat caa agg cat ggg caa ggc acc tat tta tac gca gag      559
 Trp Phe Ala His Gln Arg His Gly Gln Gly Thr Tyr Leu Tyr Ala Glu
             120                 125                 130

 acg ggc agt aag tat gtt ggc acc tgg gtg aac gga cag cag gag ggc      607
 Thr Gly Ser Lys Tyr Val Gly Thr Trp Val Asn Gly Gln Gln Glu Gly
         135                 140                 145

 acg gcc gag ctc att cac ctg aac cac agg tac cag ggc aag ttc ttg      655
 Thr Ala Glu Leu Ile His Leu Asn His Arg Tyr Gln Gly Lys Phe Leu
     150                 155                 160

 aac aaa aat cct gtt ggc cct gga aag tat gta ttt gat gtt ggg tgt      703
 Asn Lys Asn Pro Val Gly Pro Gly Lys Tyr Val Phe Asp Val Gly Cys
 165                 170                 175                 180

 gaa caa cat ggt gaa tat cgt tta aca gat atg gaa aga gga gaa gag      751
 Glu Gln His Gly Glu Tyr Arg Leu Thr Asp Met Glu Arg Gly Glu Glu
                 185                 190                 195

 gaa gag gag gaa gaa tta gta act gtt gtt cca aaa tgg aaa gct acc      799
 Glu Glu Glu Glu Glu Leu Val Thr Val Val Pro Lys Trp Lys Ala Thr
             200                 205                 210

 caa atc act gaa ttg gcc ctg tgg aca cca act ctc ccc aaa aag ccg      847
 Gln Ile Thr Glu Leu Ala Leu Trp Thr Pro Thr Leu Pro Lys Lys Pro
         215                 220                 225

 acc tct acg gat gga cct ggc caa gac gct cca gga gct gag agt gca      895
 Thr Ser Thr Asp Gly Pro Gly Gln Asp Ala Pro Gly Ala Glu Ser Ala
     230                 235                 240

 gga gaa ccc ggg gag gag gcc cag gct ctg ctg gag ggc ttc gag ggt      943
 Gly Glu Pro Gly Glu Glu Ala Gln Ala Leu Leu Glu Gly Phe Glu Gly
 245                 250                 255                 260

 gag atg gac atg agg cct gga gat gaa gat gca gac gtc ctc cgg gaa      991
 Glu Met Asp Met Arg Pro Gly Asp Glu Asp Ala Asp Val Leu Arg Glu
                 265                 270                 275

 gag agc cgg gag tat gac cag gag gag ttc cgc tat gac atg gat gag     1039
 Glu Ser Arg Glu Tyr Asp Gln Glu Glu Phe Arg Tyr Asp Met Asp Glu
             280                 285                 290

 gga aac att aat tct gaa gaa gaa gaa act aga cag tca gac ctc cag     1087
 Gly Asn Ile Asn Ser Glu Glu Glu Glu Thr Arg Gln Ser Asp Leu Gln
         295                 300                 305

 gac taa gatgaagtga gccgagagga gatcgtatca taagaatgct tctgtcgtta      1143
 Asp 






      <210> 113
      <211> 1236
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (162)..(1193)

      <400> 113
 gcttcgtccg cgtcagcctg gtcccccggc ttccccatct ccgggctggg agggaggcgg     60

 gaccggccgc gtctccatgg cgacgcggga cgcggcggtg gaggcggttg ctacccacct    120

 gctagaggcg ctgcggctgt gatccaggct ggggcgagac c    atg tcg gac ctg     173
                                                  Met Ser Asp Leu
                                                    1

 ggc tcg gag gag ttg gag gag gag gga gag aat gat att ggg gaa tat      221
 Gly Ser Glu Glu Leu Glu Glu Glu Gly Glu Asn Asp Ile Gly Glu Tyr
   5                  10                  15                  20

 gag ggg ggt cgg aat gag gca ggc gaa agg cac gga cgt ggg agg gca      269
 Glu Gly Gly Arg Asn Glu Ala Gly Glu Arg His Gly Arg Gly Arg Ala
                  25                  30                  35

 cgg cta ccc aac ggg gac acc tac gaa ggg agc tac gaa ttc ggt aaa      317
 Arg Leu Pro Asn Gly Asp Thr Tyr Glu Gly Ser Tyr Glu Phe Gly Lys
              40                  45                  50

 aga cat ggc cag gtc gga atc gag gaa ttc gaa agg cac gga cgt ggg      365
 Arg His Gly Gln Val Gly Ile Glu Glu Phe Glu Arg His Gly Arg Gly
          55                  60                  65

 agg gct cgg ata ccc aac agg gac acc tac gaa ggg agc tac gaa ttc      413
 Arg Ala Arg Ile Pro Asn Arg Asp Thr Tyr Glu Gly Ser Tyr Glu Phe
      70                  75                  80

 ggt aaa aga cat ggc cag ggg atc tac aaa ttt aaa aat ggt gct cga      461
 Gly Lys Arg His Gly Gln Gly Ile Tyr Lys Phe Lys Asn Gly Ala Arg
  85                  90                  95                 100

 tat atc gga gaa tat gtt aga aat aaa aag cac ggt caa ggc act ttt      509
 Tyr Ile Gly Glu Tyr Val Arg Asn Lys Lys His Gly Gln Gly Thr Phe
                 105                 110                 115

 ata tat cca gat gga tcc aga tat gaa gga gag tgg gca aat gac ctg      557
 Ile Tyr Pro Asp Gly Ser Arg Tyr Glu Gly Glu Trp Ala Asn Asp Leu
             120                 125                 130

 cgg cac ggc cat ggc gta tac tac tac atc aat aat gac acc tac act      605
 Arg His Gly His Gly Val Tyr Tyr Tyr Ile Asn Asn Asp Thr Tyr Thr
         135                 140                 145

 gga gag tgg ttt gct cat caa agg cat ggg caa ggc acc tat tta tac      653
 Gly Glu Trp Phe Ala His Gln Arg His Gly Gln Gly Thr Tyr Leu Tyr
     150                 155                 160

 gcg gag acg ggc agt aag tat gtt ggc acc tgg gtg aac gga cag cag      701
 Ala Glu Thr Gly Ser Lys Tyr Val Gly Thr Trp Val Asn Gly Gln Gln
 165                 170                 175                 180

 gag ggc acg gcc gag ctc att cac ctg aac cac agg tac cag ggc aag      749
 Glu Gly Thr Ala Glu Leu Ile His Leu Asn His Arg Tyr Gln Gly Lys
                 185                 190                 195

 ttc ttg aac aaa aat cct gtt ggc cct gga aag tat gta ttt gat gtt      797
 Phe Leu Asn Lys Asn Pro Val Gly Pro Gly Lys Tyr Val Phe Asp Val
             200                 205                 210

 ggg tgt gaa caa cat ggt gaa tat cgt tta aca gat atg gaa aga gga      845
 Gly Cys Glu Gln His Gly Glu Tyr Arg Leu Thr Asp Met Glu Arg Gly
         215                 220                 225

 gaa gag gaa gag gag gaa gaa tta gta act gtt gtt cca aaa tgg aaa      893
 Glu Glu Glu Glu Glu Glu Glu Leu Val Thr Val Val Pro Lys Trp Lys
     230                 235                 240

 gct acc caa atc act gaa ttg gcc ctg tgg aca cca act ctc ccc aaa      941
 Ala Thr Gln Ile Thr Glu Leu Ala Leu Trp Thr Pro Thr Leu Pro Lys
 245                 250                 255                 260

 aag ccg acc tct acg gat gga cct ggc caa gac gct cca gga gct gag      989
 Lys Pro Thr Ser Thr Asp Gly Pro Gly Gln Asp Ala Pro Gly Ala Glu
                 265                 270                 275

 agt gca gga gaa ccc ggg gag gag gcc cag gct ctg ctg gag ggc ttc     1037
 Ser Ala Gly Glu Pro Gly Glu Glu Ala Gln Ala Leu Leu Glu Gly Phe
             280                 285                 290

 gag ggt gag atg gac atg agg cct gga gat gaa gat gca gac gtc ctc     1085
 Glu Gly Glu Met Asp Met Arg Pro Gly Asp Glu Asp Ala Asp Val Leu
         295                 300                 305

 cgg gaa gag agc cgg gag tat gac cag gag gag ttc cgc tat gac atg     1133
 Arg Glu Glu Ser Arg Glu Tyr Asp Gln Glu Glu Phe Arg Tyr Asp Met
     310                 315                 320

 gat gag gga aac att aat tct gaa gaa gaa gaa act aga cag tca gac     1181
 Asp Glu Gly Asn Ile Asn Ser Glu Glu Glu Glu Thr Arg Gln Ser Asp
 325                 330                 335                 340

 ctc cag gac taa gat gaagtgagcc gagaggagat cgtatcataa gaatgcttct     1236
 Leu Gln Asp 






      <210> 114
      <211> 954
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (248)..(778)

      <400> 114
 tggcacgagg attacatttc acttggttac agctgactgg ggattttaat catttggagc     60

 cacactgaaa aaaaaatttc cccctgcaat ctactcttaa ctgatagtcg ctaactttgg    120

 ttatgtgtgt ctattcagaa tattacatta attgatttct caaacaaagg tcctttctga    180

 aatggtatct atgattcagc tattcaaaac ctaatgaagt tggtgactat gacaatgtgg    240

 agaaatc  atg aca gaa aat gtg gtt tgt act ggg gct gtc aat gct gta     289
          Met Thr Glu Asn Val Val Cys Thr Gly Ala Val Asn Ala Val
            1               5                  10

 aag gaa gtt tgg gaa aaa aga ata aag aaa ctc aat gaa gac ctg aag      337
 Lys Glu Val Trp Glu Lys Arg Ile Lys Lys Leu Asn Glu Asp Leu Lys
  15                  20                  25                  30

 cga gag aag gaa ttt caa cac aag cta gtg cgg atc tgg gaa gaa cga      385
 Arg Glu Lys Glu Phe Gln His Lys Leu Val Arg Ile Trp Glu Glu Arg
                  35                  40                  45

 gta agc tta acc aag cta aga gaa aag gtc acc agg gaa gat gga aga      433
 Val Ser Leu Thr Lys Leu Arg Glu Lys Val Thr Arg Glu Asp Gly Arg
              50                  55                  60

 gtc att ttg aag ata gaa aaa gag gaa tgg aag acc ctc cct tct tct      481
 Val Ile Leu Lys Ile Glu Lys Glu Glu Trp Lys Thr Leu Pro Ser Ser
          65                  70                  75

 ctg ctg aaa ctg aat caa cta cag gaa tgg caa ctt cat aga act ggt      529
 Leu Leu Lys Leu Asn Gln Leu Gln Glu Trp Gln Leu His Arg Thr Gly
      80                  85                  90

 ttg ctg aaa att cct gaa ttc att gga aga ttc cag aac ctc att gtg      577
 Leu Leu Lys Ile Pro Glu Phe Ile Gly Arg Phe Gln Asn Leu Ile Val
  95                 100                 105                 110

 tta gat tta tct cga aac aca att tca gag ata cca cca ggg att gga      625
 Leu Asp Leu Ser Arg Asn Thr Ile Ser Glu Ile Pro Pro Gly Ile Gly
                 115                 120                 125

 ctg ctt act aga ctt cag gaa ctg att ctc agc tac aac aaa atc aag      673
 Leu Leu Thr Arg Leu Gln Glu Leu Ile Leu Ser Tyr Asn Lys Ile Lys
             130                 135                 140

 act gtc ccc aag gaa cta agt aat tgt gcc agc ttg gag aaa cta gaa      721
 Thr Val Pro Lys Glu Leu Ser Asn Cys Ala Ser Leu Glu Lys Leu Glu
         145                 150                 155

 ctg gct gtt aac aga gat ata tgt gat ctt cca caa gaa gtt cag gaa      769
 Leu Ala Val Asn Arg Asp Ile Cys Asp Leu Pro Gln Glu Val Gln Glu
     160                 165                 170

 ttc tgg taa acttaac tcaccttgat ctggttttga acggattact acaacccctg      825
 Phe Trp 
 175

 gtgtgttgac acgcctgctt tgtggtggct ggagcacaaa ctgacacttc tggttaaaac    885

 ggacttcttg ttgcgcggac agaaataggt gggccacaca ataaatgctt tgtcaaagga    945

 tctcgggaa                                                            954




      <210> 115
      <211> 1545
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (162)..(1253)

      <400> 115
 actgaaaaca ctggcactga aaacatttcc tggtggttgc ccttcacttg aatcaccagc     60

 ttcaaaatgc atgggacgcc taaaggcatg attttctctt ctgtctccga tctgtatgga    120

 gaaagtgaaa atgggctttc actgccaact ccatagatct t    atg gct ccg ggc     173
                                                  Met Ala Pro Gly
                                                    1

 gaa aag gaa agc ggg gag ggc cca gcc aag agc gcc ctc cgg aag ata      221
 Glu Lys Glu Ser Gly Glu Gly Pro Ala Lys Ser Ala Leu Arg Lys Ile
   5                  10                  15                  20

 cgc aca gcc acc ctg gtc atc agc ttg gcc cga ggt tgg cag cag tgg      269
 Arg Thr Ala Thr Leu Val Ile Ser Leu Ala Arg Gly Trp Gln Gln Trp
                  25                  30                  35

 gcg aat gag aac agc atc agg cag gcc cag gag cct aca ggc tgg ctg      317
 Ala Asn Glu Asn Ser Ile Arg Gln Ala Gln Glu Pro Thr Gly Trp Leu
              40                  45                  50

 ccg gga ggg acc cag gac tca cct caa gct cct aaa cca atc aca ccc      365
 Pro Gly Gly Thr Gln Asp Ser Pro Gln Ala Pro Lys Pro Ile Thr Pro
          55                  60                  65

 cct act tca cac cag aaa gct cag agt gcc cca aag tcg cca ccc cgc      413
 Pro Thr Ser His Gln Lys Ala Gln Ser Ala Pro Lys Ser Pro Pro Arg
      70                  75                  80

 ctg cca gaa gga cat gga gat gga caa agc tca gag aaa gcc cct gag      461
 Leu Pro Glu Gly His Gly Asp Gly Gln Ser Ser Glu Lys Ala Pro Glu
  85                  90                  95                 100

 gtt tct cac atc aaa aag aaa gag gtg tcc aaa acg gtg gtc agc aag      509
 Val Ser His Ile Lys Lys Lys Glu Val Ser Lys Thr Val Val Ser Lys
                 105                 110                 115

 act tat gag aga gga ggg gac aag ttg gaa agg gta gca gag act ctt      557
 Thr Tyr Glu Arg Gly Gly Asp Lys Leu Glu Arg Val Ala Glu Thr Leu
             120                 125                 130

 tgc ttt cct gac aga gga ggg tgc ctg cat gag gag gag aaa tac tcc      605
 Cys Phe Pro Asp Arg Gly Gly Cys Leu His Glu Glu Glu Lys Tyr Ser
         135                 140                 145

 ctc tac agg aag atc tat gga gtt ggc agt gaa agc cca ttt tca ctt      653
 Leu Tyr Arg Lys Ile Tyr Gly Val Gly Ser Glu Ser Pro Phe Ser Leu
     150                 155                 160

 tct cca tac aga tcg gag aca gaa gag aaa atc atg cct tta ggc gtc      701
 Ser Pro Tyr Arg Ser Glu Thr Glu Glu Lys Ile Met Pro Leu Gly Val
 165                 170                 175                 180

 cca tgc att ttg aag ctg gtg att caa gtg aag ggc aac cac cag gaa      749
 Pro Cys Ile Leu Lys Leu Val Ile Gln Val Lys Gly Asn His Gln Glu
                 185                 190                 195

 atg ttt tca gtg cca gtg ttt tca gtg gta aac aga ttt aca gag aaa      797
 Met Phe Ser Val Pro Val Phe Ser Val Val Asn Arg Phe Thr Glu Lys
             200                 205                 210

 ctc aac tgc aaa gcc caa cag aaa tat agc cca gtg ggc aac ttg aaa      845
 Leu Asn Cys Lys Ala Gln Gln Lys Tyr Ser Pro Val Gly Asn Leu Lys
         215                 220                 225

 ggg aga tgg cag cag tgg gct gat gaa cac ata caa tcc cag aag ctc      893
 Gly Arg Trp Gln Gln Trp Ala Asp Glu His Ile Gln Ser Gln Lys Leu
     230                 235                 240

 aat cct ttc agt gaa gag ttt gat tac gag ctg gcc atg tcc acc cgc      941
 Asn Pro Phe Ser Glu Glu Phe Asp Tyr Glu Leu Ala Met Ser Thr Arg
 245                 250                 255                 260

 cta cac aaa gga gat gag ggc tat ggc cgc ccc aaa gaa gga acc aaa      989
 Leu His Lys Gly Asp Glu Gly Tyr Gly Arg Pro Lys Glu Gly Thr Lys
                 265                 270                 275

 act gct gaa agg gcc aag cgt gct gag gag cac atc tac agg gaa atg     1037
 Thr Ala Glu Arg Ala Lys Arg Ala Glu Glu His Ile Tyr Arg Glu Met
             280                 285                 290

 atg gac atg tgc ttc att atc tgc aca atg gct cgc cac aga cga gat     1085
 Met Asp Met Cys Phe Ile Ile Cys Thr Met Ala Arg His Arg Arg Asp
         295                 300                 305

 ggc aag atc cag gtt act ttt gga gat ctc ttt gac aga tac gtt cgt     1133
 Gly Lys Ile Gln Val Thr Phe Gly Asp Leu Phe Asp Arg Tyr Val Arg
     310                 315                 320

 att tca gat aaa gta gtg ggc att ctc atg cgt gcc agg aaa cat gga     1181
 Ile Ser Asp Lys Val Val Gly Ile Leu Met Arg Ala Arg Lys His Gly
 325                 330                 335                 340

 ctg gta gac ttt gaa gga gag atg cta tgg caa ggc cga gat gac cat     1229
 Leu Val Asp Phe Glu Gly Glu Met Leu Trp Gln Gly Arg Asp Asp His
                 345                 350                 355

 gtt gtg att acg cta ctc aag tga accttcaaaa acaaaagcca aatttggccc    1283
 Val Val Ile Thr Leu Leu Lys 
             360

 actatggtct taatgctaaa tgctcatgta ggtaaaatga aaatgcaaac tctctgtaat   1343

 aagttagtaa atattaaaca atttttacat aaacgacttt ctggcattct atttctatct   1403

 agaatgagga attttggaga ttttgagaag gcacaaagca tttcagaaag cacatagaat   1463

 gttaatgtat aataatagta ttaatagttg aaattccaca gggtgttttt gtttttgttt   1523

 tgagacagat tctctttatg tc                                            1545




      <210> 116
      <211> 2152
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (455)..(1273)

      <400> 116
 gatggaggat gaggaggcca tggcagaggt cggtgatgat gctgtgggag gtgacgagtc     60

 cacagctggc tgggctcagg gctgcgggga ctgtccccag caccagccct cagcaggggc    120

 tcgccggcaa caccggcgga cggctcacag cccggcatct gccacccacc ccttccactg    180

 cagccagtgt cagcgcagtt tcagctccgc caaccggctg caggctcatg ggcgggccca    240

 tgttggtggc acacatgagt gtacaacctg ctccaaggtc ttcaagaaag cagcatcgct    300

 tgagcagcac ttgcggctgc atcgcgggga agcccgctac ctctgtgtag actgtggccg    360

 cggctttggc acagaactca cgttggtggc tcaccggcgg gcccacactg ccaacccatt    420

 gcatcgctgt cgttgcggca agacgttcag caac    atg acc aag ttc ctc tac     472
                                          Met Thr Lys Phe Leu Tyr
                                            1               5

 cac cgg cgc act cac gcc ggc aaa agc ggg gca cct ccc aca gga gca      520
 His Arg Arg Thr His Ala Gly Lys Ser Gly Ala Pro Pro Thr Gly Ala
              10                  15                  20

 aca gct ccc cca gct cca gcg gag ccc acc cct cca cca cca ccc cct      568
 Thr Ala Pro Pro Ala Pro Ala Glu Pro Thr Pro Pro Pro Pro Pro Pro
          25                  30                  35

 gcc cca cct gcc cag ctg ccc tgc cca cag tgc tcc aag tcc ttt gcc      616
 Ala Pro Pro Ala Gln Leu Pro Cys Pro Gln Cys Ser Lys Ser Phe Ala
      40                  45                  50

 tca gct tcc cgg ctg tcc cgg cac cgg cgt gca gta cac ggg ccc cct      664
 Ser Ala Ser Arg Leu Ser Arg His Arg Arg Ala Val His Gly Pro Pro
  55                  60                  65                  70

 gaa cgg cgt cac cgc tgt ggg gtt tgt ggc aag ggc ttc aag aag ctg      712
 Glu Arg Arg His Arg Cys Gly Val Cys Gly Lys Gly Phe Lys Lys Leu
                  75                  80                  85

 atc cac gtg cgc aac cac ctg cgg aca cac acg ggt gag agg ccc ttc      760
 Ile His Val Arg Asn His Leu Arg Thr His Thr Gly Glu Arg Pro Phe
              90                  95                 100

 cag tgc cac tca tgt ggc aag acc ttt gct tct ttg gcc aac ctc agc      808
 Gln Cys His Ser Cys Gly Lys Thr Phe Ala Ser Leu Ala Asn Leu Ser
         105                 110                 115

 cgc cac cag ctg acc cat acg ggt gca cgt ccc tac caa tgc ctg gac      856
 Arg His Gln Leu Thr His Thr Gly Ala Arg Pro Tyr Gln Cys Leu Asp
     120                 125                 130

 tgt ggc aag cgc ttc aca cag agc tcc aac ctg cag cag cac cgg cgg      904
 Cys Gly Lys Arg Phe Thr Gln Ser Ser Asn Leu Gln Gln His Arg Arg
 135                 140                 145                 150

 ttg cac ttg cgg cca gtc gcc ttt gcc cgc gcc ccc cgc ctc ccc atc      952
 Leu His Leu Arg Pro Val Ala Phe Ala Arg Ala Pro Arg Leu Pro Ile
                 155                 160                 165

 act ggt ctc tac aac aag agt ccc tac tac tgc ggg act tgt ggc cgc     1000
 Thr Gly Leu Tyr Asn Lys Ser Pro Tyr Tyr Cys Gly Thr Cys Gly Arg
             170                 175                 180

 tgg ttc cgc gcc atg gcg ggc ttg cga ctg cat cag cgg gtc cat gcc     1048
 Trp Phe Arg Ala Met Ala Gly Leu Arg Leu His Gln Arg Val His Ala
         185                 190                 195

 cga gct cgg act ttg acg cta cag cct ccc aga tca cca tct cct gcc     1096
 Arg Ala Arg Thr Leu Thr Leu Gln Pro Pro Arg Ser Pro Ser Pro Ala
     200                 205                 210

 cca ccc cca cct cca gag cct caa cag act atc atg tgc aca gag ctg     1144
 Pro Pro Pro Pro Pro Glu Pro Gln Gln Thr Ile Met Cys Thr Glu Leu
 215                 220                 225                 230

 ggg gag acc atc gcc atc att gag aca tcc cag cca ctg gcg ctt gag     1192
 Gly Glu Thr Ile Ala Ile Ile Glu Thr Ser Gln Pro Leu Ala Leu Glu
                 235                 240                 245

 gac acc ctg cag ctg tgc cag gct gca ctg ggg gcc agt gaa gca ggc     1240
 Asp Thr Leu Gln Leu Cys Gln Ala Ala Leu Gly Ala Ser Glu Ala Gly
             250                 255                 260

 ggg ctc ttg cag ttg gac acg gcc ttc gtg tga cgcagctg aaaagcaaca     1291
 Gly Leu Leu Gln Leu Asp Thr Ala Phe Val 
         265                 270

 acaaaagggt ttggttgcaa cagccagtgt gggtacctct ggggagagag gacctcctct   1351

 gacaaactgg tctggtaccc accatgtgcc aggatccacc ctggcctctt tttacccact   1411

 gactccccag aacaaccctt ccaggcttct cttgtcatct ttctctgcct gaggggaaac   1471

 tgaagctctg aaatgcgatg tgatctgtac caggtcaccc agctatgctg caaagtgggt   1531

 tggccaaggc cctttgcact gcatcaccct ggtgcccagc aacatcaggt aaccttcact   1591

 gagcaccaag cttatgccag gtctgtgctg gccactctca tatacctctt cagatcctct   1651

 gcttgtaccc ccagcccttg ccttccctgg attttgggca cccaggactt tgctctgcct   1711

 ggtggagggt acttgatttc tctgggcttc cttcatctca attctgacag tgtggaagga   1771

 aatctgtagg tacccaggtc ctcagctcca gactgggtga tgctggagac ccaggagcaa   1831

 gtcagcacag gctctgccca caggaggcat gcacaatctg gtaggagaaa cgcacaagta   1891

 cagatagctt gctctctgag tgtgtctcat tgattcattc agcctgtgtg tcctaaagcc   1951

 tcccttctcc catactgggt gatgctgggg gcagagatga gtcaggccta aagcttctct   2011

 gggctgtgat ggggatgtgc agggacagtg ggatcccaag aaacagacct ccatggtggg   2071

 agatcacgag ttaaggactt cctagagaag gtagtccctg aaggaaaagt acgaatctgg   2131

 cagtgaaaga ggaaaagaac a                                             2152




      <210> 117
      <211> 618
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(618)

      <400> 117
  atg gca gcc agg gac gcc act tca ggc agc ctg tca gag gag agc agt      48
  Met Ala Ala Arg Asp Ala Thr Ser Gly Ser Leu Ser Glu Glu Ser Ser
    1               5                  10                  15

 gct ttg gac ctg cca tca gtg tgt gac ata aga gat tac gtc ctg cag       96
 Ala Leu Asp Leu Pro Ser Val Cys Asp Ile Arg Asp Tyr Val Leu Gln
              20                  25                  30

 gga ccc agc caa gaa gcc aac agc gag gct ttc agt tct ttg gaa ttc      144
 Gly Pro Ser Gln Glu Ala Asn Ser Glu Ala Phe Ser Ser Leu Glu Phe
          35                  40                  45

 cat tct ttt cct tat tct tct gat gtg gat cca gac acc agt aac tta      192
 His Ser Phe Pro Tyr Ser Ser Asp Val Asp Pro Asp Thr Ser Asn Leu
      50                  55                  60

 aat ata gaa caa aat aac tcc tgg acc gct gag aac ttc tgg ctt gac      240
 Asn Ile Glu Gln Asn Asn Ser Trp Thr Ala Glu Asn Phe Trp Leu Asp
  65                  70                  75                  80

 cct gct gtg aaa ggc cag tca gag aag gaa gag gat gat ggc ctt cgg      288
 Pro Ala Val Lys Gly Gln Ser Glu Lys Glu Glu Asp Asp Gly Leu Arg
                  85                  90                  95

 aaa tcc ctg gat aga ttc tat gaa atg ttt ggc cat cca cag cca ggc      336
 Lys Ser Leu Asp Arg Phe Tyr Glu Met Phe Gly His Pro Gln Pro Gly
             100                 105                 110

 tct gca aac tca ctc tct gca tct gtc tgc aag tgc ctg tct cag aaa      384
 Ser Ala Asn Ser Leu Ser Ala Ser Val Cys Lys Cys Leu Ser Gln Lys
         115                 120                 125

 atc act caa cta aga ggc cag gag agc caa aag tat gcc ctc cgc agt      432
 Ile Thr Gln Leu Arg Gly Gln Glu Ser Gln Lys Tyr Ala Leu Arg Ser
     130                 135                 140

 ttt caa atg gcc cgg gtg atc ttc aac cgg gac ggc tgc tcc gtc tta      480
 Phe Gln Met Ala Arg Val Ile Phe Asn Arg Asp Gly Cys Ser Val Leu
 145                 150                 155                 160

 cag agg cat tcc agg gac acc cac ttc tac cca ctg gag gaa gga agt      528
 Gln Arg His Ser Arg Asp Thr His Phe Tyr Pro Leu Glu Glu Gly Ser
                 165                 170                 175

 aca tct ttg gat gat gaa aag cca aac cca gga ctg tca aag gat att      576
 Thr Ser Leu Asp Asp Glu Lys Pro Asn Pro Gly Leu Ser Lys Asp Ile
             180                 185                 190

 act cat ttc ctc ttg cag cag aat gta atg aaa gac ctg taa              618
 Thr His Phe Leu Leu Gln Gln Asn Val Met Lys Asp Leu 
         195                 200                 205





      <210> 118
      <211> 486
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(486)

      <400> 118
  atg gga agg gag ggg gta gca gct ggg agt ctg ctc ttc cag ctg ggg      48
  Met Gly Arg Glu Gly Val Ala Ala Gly Ser Leu Leu Phe Gln Leu Gly
    1               5                  10                  15

 gcc ctc cca ccc cca tgg gga gga aag acg tca agc tcc agc cac tgg       96
 Ala Leu Pro Pro Pro Trp Gly Gly Lys Thr Ser Ser Ser Ser His Trp
              20                  25                  30

 ccc cgg tgg gtc cca aag ccc cac ccc tca tgc tct cct ctg gtc acc      144
 Pro Arg Trp Val Pro Lys Pro His Pro Ser Cys Ser Pro Leu Val Thr
          35                  40                  45

 tct att tac gct cac atg ccc ctt cct gtc ctt cac ctg cac gtc acc      192
 Ser Ile Tyr Ala His Met Pro Leu Pro Val Leu His Leu His Val Thr
      50                  55                  60

 agc agg tcc cgc caa ccc caa atc tat ctg gtg aaa acc tgg aga aca      240
 Ser Arg Ser Arg Gln Pro Gln Ile Tyr Leu Val Lys Thr Trp Arg Thr
  65                  70                  75                  80

 aga gcg gag tct aag aga gat gta aat gaa aac aca gat cac aga cac      288
 Arg Ala Glu Ser Lys Arg Asp Val Asn Glu Asn Thr Asp His Arg His
                  85                  90                  95

 acc aga agg gaa gcg ttg ttt ccg cgg gga aag gag atg gaa agg gga      336
 Thr Arg Arg Glu Ala Leu Phe Pro Arg Gly Lys Glu Met Glu Arg Gly
             100                 105                 110

 aga gaa ggt gaa gaa ttc tgc gcc cga agc tcg ggt tgg tgt ttg ctc      384
 Arg Glu Gly Glu Glu Phe Cys Ala Arg Ser Ser Gly Trp Cys Leu Leu
         115                 120                 125

 aac tgc ttt act cat ttt aac cct ttc acc tat cct ggg aga aac cca      432
 Asn Cys Phe Thr His Phe Asn Pro Phe Thr Tyr Pro Gly Arg Asn Pro
     130                 135                 140

 ggc ttg tca cct ttt cat gtt ggg ttg ttt att ggc ctc tta agt gag      480
 Gly Leu Ser Pro Phe His Val Gly Leu Phe Ile Gly Leu Leu Ser Glu
 145                 150                 155                 160

 aat tga                                                              486
 Asn 






      <210> 119
      <211> 789
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(516)

      <400> 119
  atg gcg gat caa ggt gaa aag gag aac ccc atg cag aaa ctt cac atc      48
  Met Ala Asp Gln Gly Glu Lys Glu Asn Pro Met Gln Lys Leu His Ile
    1               5                  10                  15

 tgc aag ctc tgc ctc aac atc tgt gtg gag gag agt gga gac aga cta       96
 Cys Lys Leu Cys Leu Asn Ile Cys Val Glu Glu Ser Gly Asp Arg Leu
              20                  25                  30

 acc cga gca gcc aag gca ttg gag cag ctc aca ggg cag aag cta gat      144
 Thr Arg Ala Ala Lys Ala Leu Glu Gln Leu Thr Gly Gln Lys Leu Asp
          35                  40                  45

 aca atc aga tcc tct ggc atg cag aga aat gaa aag att gct gtc cac      192
 Thr Ile Arg Ser Ser Gly Met Gln Arg Asn Glu Lys Ile Ala Val His
      50                  55                  60

 tgc aca gtt caa gga tcc aag gca gaa gaa atc ctg gag aag gat cta      240
 Cys Thr Val Gln Gly Ser Lys Ala Glu Glu Ile Leu Glu Lys Asp Leu
  65                  70                  75                  80

 aag gtg cag aag tat gag tta aga aaa aat aac ttc tca gat act aga      288
 Lys Val Gln Lys Tyr Glu Leu Arg Lys Asn Asn Phe Ser Asp Thr Arg
                  85                  90                  95

 aac ttt ggt ttt ggg atc cag gaa cac atc gat ttg ggt atc ata tat      336
 Asn Phe Gly Phe Gly Ile Gln Glu His Ile Asp Leu Gly Ile Ile Tyr
             100                 105                 110

 gac cca agc att ggt atc tac ggc ctg gac ttc tat gtg gtg ctg ggt      384
 Asp Pro Ser Ile Gly Ile Tyr Gly Leu Asp Phe Tyr Val Val Leu Gly
         115                 120                 125

 agg cca ggt ttc agc atc gca gac aag aag cgc agg aca ggc tgc att      432
 Arg Pro Gly Phe Ser Ile Ala Asp Lys Lys Arg Arg Thr Gly Cys Ile
     130                 135                 140

 ggg gcc aaa cac aga atc agc aaa gag gac gcc atg cgc tgg ttc cag      480
 Gly Ala Lys His Arg Ile Ser Lys Glu Asp Ala Met Arg Trp Phe Gln
 145                 150                 155                 160

 cag aag tat gat gag atc atc ctt cct ggc aga taa atgc ccgtttctat      530
 Gln Lys Tyr Asp Glu Ile Ile Leu Pro Gly Arg 
                 165                 170

 ccaaaagagc aataaaaagt tttcaggtcg acgacgccgg acattgtgta gttagtaggc    590

 gaccggtcta gagggtccaa gcttgctgac gaggacatgc gacgccaagc tcttccagag    650

 tggaccgcag attcaactca atggccgccg tataaagcgg gaacggggaa aacagcggta    710

 ccgagtagag gccttggaga aatccgcctt gcacggggag attgggaagg gccctcagtg    770

 ccttgcgaag gtggcactt                                                 789




      <210> 120
      <211> 1567
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(1310)

      <400> 120
 atcagtggct gaggccagag atccactcaa aagagcagat cttggaa  atg ctg gtg      56
                                                      Met Leu Val
                                                        1

 tta gag cag ttc ctg agc att ctg ccc aag gag acc cac aac tgg gtg      104
 Leu Glu Gln Phe Leu Ser Ile Leu Pro Lys Glu Thr His Asn Trp Val
       5                  10                  15

 cag aag cat cat cca cag aat gtc aaa cag gct ctg gtc ctg gtg gaa      152
 Gln Lys His His Pro Gln Asn Val Lys Gln Ala Leu Val Leu Val Glu
  20                  25                  30                  35

 ttc ttg cag agg gag cct gat gga aca aag aat gag gtc aca gcc cat      200
 Phe Leu Gln Arg Glu Pro Asp Gly Thr Lys Asn Glu Val Thr Ala His
                  40                  45                  50

 gag ctg cga aag gag gca gtg ctc ttg gga gga aca gca gtg gcc cca      248
 Glu Leu Arg Lys Glu Ala Val Leu Leu Gly Gly Thr Ala Val Ala Pro
              55                  60                  65

 ggc ttc aag tgg aag cca gca gag ccc caa cca atg ggt gtg ttc cag      296
 Gly Phe Lys Trp Lys Pro Ala Glu Pro Gln Pro Met Gly Val Phe Gln
          70                  75                  80

 aaa gaa tat tgg aat aca tac cgg gta cta caa gaa cag ctg ggc tgg      344
 Lys Glu Tyr Trp Asn Thr Tyr Arg Val Leu Gln Glu Gln Leu Gly Trp
      85                  90                  95

 aac act cac aaa gaa acc cag cct gta tat gaa aga gct gtg cat gat      392
 Asn Thr His Lys Glu Thr Gln Pro Val Tyr Glu Arg Ala Val His Asp
 100                 105                 110                 115

 caa cag atg tta gcc ctt tct gag cag aaa aga atc aaa cac tgg aag      440
 Gln Gln Met Leu Ala Leu Ser Glu Gln Lys Arg Ile Lys His Trp Lys
                 120                 125                 130

 atg gca tct aaa ctc atc ctg cct gag tcc ctg agt ttg ttg aca ttt      488
 Met Ala Ser Lys Leu Ile Leu Pro Glu Ser Leu Ser Leu Leu Thr Phe
             135                 140                 145

 gaa gat gtg gct gtg tat ttt tct gag gaa gag tgg caa tta ttg aat      536
 Glu Asp Val Ala Val Tyr Phe Ser Glu Glu Glu Trp Gln Leu Leu Asn
         150                 155                 160

 cct ctt gag aag act ctc tac aat gat gta atg cag gat atc tat gag      584
 Pro Leu Glu Lys Thr Leu Tyr Asn Asp Val Met Gln Asp Ile Tyr Glu
     165                 170                 175

 act gtc atc tct cta ggg tta aag cta aaa aat gac act gga aat gat      632
 Thr Val Ile Ser Leu Gly Leu Lys Leu Lys Asn Asp Thr Gly Asn Asp
 180                 185                 190                 195

 cat cct ata tct gtt tct aca tca gaa ata caa aca tca gga tgc gaa      680
 His Pro Ile Ser Val Ser Thr Ser Glu Ile Gln Thr Ser Gly Cys Glu
                 200                 205                 210

 gta tca aaa aag acc aga atg aaa att gcc cag aaa aca atg ggc agg      728
 Val Ser Lys Lys Thr Arg Met Lys Ile Ala Gln Lys Thr Met Gly Arg
             215                 220                 225

 gaa aat cct ggt gat aca cac agt gta cag aaa tgg cat cga gct ttt      776
 Glu Asn Pro Gly Asp Thr His Ser Val Gln Lys Trp His Arg Ala Phe
         230                 235                 240

 cca agg aag aaa aga aag aaa cct gca act tgt aaa caa gag ctt cca      824
 Pro Arg Lys Lys Arg Lys Lys Pro Ala Thr Cys Lys Gln Glu Leu Pro
     245                 250                 255

 aaa ctt atg gat ctt cat ggg aaa ggc ccc aca ggg gag aaa cct ttt      872
 Lys Leu Met Asp Leu His Gly Lys Gly Pro Thr Gly Glu Lys Pro Phe
 260                 265                 270                 275

 aag tgt cag gaa tgt ggg aaa agc ttc aga gtt agc tct gat ctt att      920
 Lys Cys Gln Glu Cys Gly Lys Ser Phe Arg Val Ser Ser Asp Leu Ile
                 280                 285                 290

 aaa cac cac aga att cac act gga gag aaa ccc tat aaa tgt caa caa      968
 Lys His His Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Gln Gln
             295                 300                 305

 tgt gac agg agg ttt aga tgg agt tca gat ctt aat aag cac ttc atg     1016
 Cys Asp Arg Arg Phe Arg Trp Ser Ser Asp Leu Asn Lys His Phe Met
         310                 315                 320

 acc cat caa gga ata aaa cca tat aga tgc tca tgg tgt ggg aaa agc     1064
 Thr His Gln Gly Ile Lys Pro Tyr Arg Cys Ser Trp Cys Gly Lys Ser
     325                 330                 335

 ttt agt cat aac aca aat cta cac aca cac caa aga att cac aca gga     1112
 Phe Ser His Asn Thr Asn Leu His Thr His Gln Arg Ile His Thr Gly
 340                 345                 350                 355

 gag aag ccc ttt aaa tgt gat gaa tgt gga aaa aga ttc att cag aac     1160
 Glu Lys Pro Phe Lys Cys Asp Glu Cys Gly Lys Arg Phe Ile Gln Asn
                 360                 365                 370

 tcc cac ctt att aaa cac cag aga act cac aca ggt gag cag cct tat     1208
 Ser His Leu Ile Lys His Gln Arg Thr His Thr Gly Glu Gln Pro Tyr
             375                 380                 385

 acg tgt agc tta tgc aag aga aac ttt agt agg cga tcg agc ctt ctt     1256
 Thr Cys Ser Leu Cys Lys Arg Asn Phe Ser Arg Arg Ser Ser Leu Leu
         390                 395                 400

 aga cac cag aaa ctc cac aga aga agg gaa gca tgt cta gtg tct cca     1304
 Arg His Gln Lys Leu His Arg Arg Arg Glu Ala Cys Leu Val Ser Pro
     405                 410                 415

 aac tga ggaaagttac catgtagagc ttgactttag aagtggtgaa agaatacaaa      1360
 Asn 
 420

 attatgaggc acccaatgat aggaatctgt gattaataaa acatttggga agggtacatg   1420

 ttacacttca caaaaaggaa tctaagctgt ctgttttatt cagcattgca tcttctgtgc   1480

 ctagcacaag agttgataca taaggagtac tttataaata aaaaaatgaa agtgtagtga   1540

 tgagattcct ttagctatct atctata                                       1567




      <210> 121
      <211> 1164
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1164)

      <400> 121
  atg agg gag att gtg ctc acg cag acg ggg cag tgc ggg aac cgg atc      48
  Met Arg Glu Ile Val Leu Thr Gln Thr Gly Gln Cys Gly Asn Arg Ile
    1               5                  10                  15

 ggc gcc aag ttc tgg gag gtg atc tct gat gaa cat gcc atc gac tcc       96
 Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Ala Ile Asp Ser
              20                  25                  30

 gct ggc acc tac cgc ggg gac agg gac ctg ctg ctg aag cgt atc aac      144
 Ala Gly Thr Tyr Arg Gly Asp Arg Asp Leu Leu Leu Lys Arg Ile Asn
          35                  40                  45

 gta tac tac aat gag gcc agc ggt agc agg tat gtg ccc cgc gct gtg      192
 Val Tyr Tyr Asn Glu Ala Ser Gly Ser Arg Tyr Val Pro Arg Ala Val
      50                  55                  60

 cta act gat ctg gag ccg ggc acc ctg gac tct gtg cgc tcc ggg ccc      240
 Leu Thr Asp Leu Glu Pro Gly Thr Leu Asp Ser Val Arg Ser Gly Pro
  65                  70                  75                  80

 ttc ggc cag atc ttc agg ccg gag aac ttc atc ttg ggt cag agt ggg      288
 Phe Gly Gln Ile Phe Arg Pro Glu Asn Phe Ile Leu Gly Gln Ser Gly
                  85                  90                  95

 gcc ggg aac aac tgg gcc aag ggg tac tac aca gaa ggc acg gag ctg      336
 Ala Gly Asn Asn Trp Ala Lys Gly Tyr Tyr Thr Glu Gly Thr Glu Leu
             100                 105                 110

 atg gag tca gtg atg gac act gtg agg cgg gaa gct gag agc tgt gac      384
 Met Glu Ser Val Met Asp Thr Val Arg Arg Glu Ala Glu Ser Cys Asp
         115                 120                 125

 tgc ctg cag ggt ttc cag ctg gcc cac tcc ctg ggt ggg ggg act ggg      432
 Cys Leu Gln Gly Phe Gln Leu Ala His Ser Leu Gly Gly Gly Thr Gly
     130                 135                 140

 tct ggg atg ggt acc ctt cta ctc agt aag atc cag gag gaa tac cca      480
 Ser Gly Met Gly Thr Leu Leu Leu Ser Lys Ile Gln Glu Glu Tyr Pro
 145                 150                 155                 160

 gac agg atc ata aac aca ttc agc gtc ctg ccc tcg ctc aag gtg tca      528
 Asp Arg Ile Ile Asn Thr Phe Ser Val Leu Pro Ser Leu Lys Val Ser
                 165                 170                 175

 gat gcc gtg gtg gag ccc tat aat gcc atc ctc tca atc cac cag ctc      576
 Asp Ala Val Val Glu Pro Tyr Asn Ala Ile Leu Ser Ile His Gln Leu
             180                 185                 190

 ata gaa aat gca cat gag acc ttt tgt att gat aac gaa gca ctg cgg      624
 Ile Glu Asn Ala His Glu Thr Phe Cys Ile Asp Asn Glu Ala Leu Arg
         195                 200                 205

 ttg aat gct gac ctg cgg aag ctg gcc atg aac atg gtc cca ttt ccc      672
 Leu Asn Ala Asp Leu Arg Lys Leu Ala Met Asn Met Val Pro Phe Pro
     210                 215                 220

 tgg ctg cac ttc ttc atg cct agc ttt gct cca ctg acc agc cag ggc      720
 Trp Leu His Phe Phe Met Pro Ser Phe Ala Pro Leu Thr Ser Gln Gly
 225                 230                 235                 240

 agc cgg cag tac cag gcc ctg acg gtg gct gag ctt atc cag gag gtg      768
 Ser Arg Gln Tyr Gln Ala Leu Thr Val Ala Glu Leu Ile Gln Glu Val
                 245                 250                 255

 ttt gat gct aag aat atg atg gct gcc tgt cac atg tcc atg aag gag      816
 Phe Asp Ala Lys Asn Met Met Ala Ala Cys His Met Ser Met Lys Glu
             260                 265                 270

 gtg gat gag cag atg ctc aat ctt caa aag aac agt agc cac ttt gct      864
 Val Asp Glu Gln Met Leu Asn Leu Gln Lys Asn Ser Ser His Phe Ala
         275                 280                 285

 cat cgg ctc cct cac aat gta aaa aca gcc acg tgt gac atc cca tcc      912
 His Arg Leu Pro His Asn Val Lys Thr Ala Thr Cys Asp Ile Pro Ser
     290                 295                 300

 aag ggg cta gaa atg tcg gcc act gga atc agt aat aac acg gcc atc      960
 Lys Gly Leu Glu Met Ser Ala Thr Gly Ile Ser Asn Asn Thr Ala Ile
 305                 310                 315                 320

 cag gag ctg ttc aag cgc act atg gag cag ttc aca gcc atg ttc agg     1008
 Gln Glu Leu Phe Lys Arg Thr Met Glu Gln Phe Thr Ala Met Phe Arg
                 325                 330                 335

 cac aag gcc ttt ctc cac tgg tac acg ggt gag ggc atg gat gag atg     1056
 His Lys Ala Phe Leu His Trp Tyr Thr Gly Glu Gly Met Asp Glu Met
             340                 345                 350

 gaa ttt acc gag gcc gag agc agc ctg aaa aat ctt atg gca gag tac     1104
 Glu Phe Thr Glu Ala Glu Ser Ser Leu Lys Asn Leu Met Ala Glu Tyr
         355                 360                 365

 cag gat gcc acg gcc aag gcg gag gag ttt gag gag tct gct gag gag     1152
 Gln Asp Ala Thr Ala Lys Ala Glu Glu Phe Glu Glu Ser Ala Glu Glu
     370                 375                 380

 gag gtg gcc tag                                                     1164
 Glu Val Ala 
 385





      <210> 122
      <211> 2573
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (341)..(2113)

      <400> 122
 agcggaggta tgtccagacc cccgaggcac cgcttgcagg gcagtgacag cccgtgaggc     60

 tcggcctcga cccctggcac ccttggtccc agctacgccg gctcctggcc ttcccccaag    120

 tccgagagag aggtgggatt ctccgcgacg cagttggaaa ccgggaatcc ccttaagggt    180

 cccgttcgtg ctgcactact gactccacca tctgcaaagg gattcttgtc cagaatcccc    240

 gaaggcttta ggacagcgct tattttgttg aatgaagagt ctctaatttt cggaaagacc    300

 acaggctaaa agtcaagttg tgccttttta gccaagaagc  atg gaa gtc att cac     355
                                              Met Glu Val Ile His
                                                1               5

 ggc agg ccc tac tgt tgc agg gag ctt gaa gga gct gac ata ctg tcc      403
 Gly Arg Pro Tyr Cys Cys Arg Glu Leu Glu Gly Ala Asp Ile Leu Ser
                  10                  15                  20

 aac acc ttt tac tct aat gaa ttg cac aac ccc ctc cag acg gtt act      451
 Asn Thr Phe Tyr Ser Asn Glu Leu His Asn Pro Leu Gln Thr Val Thr
              25                  30                  35

 cgc cca act gcc tca gag gac agg tat cag gaa tta agg gag tca ctt      499
 Arg Pro Thr Ala Ser Glu Asp Arg Tyr Gln Glu Leu Arg Glu Ser Leu
          40                  45                  50

 caa caa tgt agg ctt cct tgg ggc gct gaa aga gag tat ggt ggg ata      547
 Gln Gln Cys Arg Leu Pro Trp Gly Ala Glu Arg Glu Tyr Gly Gly Ile
      55                  60                  65

 ata ccg att tca ctc ccc gag gac cac agg cca aag tat gag cct cct      595
 Ile Pro Ile Ser Leu Pro Glu Asp His Arg Pro Lys Tyr Glu Pro Pro
  70                  75                  80                  85

 cgt gtc atg ggc aaa gga cat cag cat tat gga ttt ggt gga gaa acc      643
 Arg Val Met Gly Lys Gly His Gln His Tyr Gly Phe Gly Gly Glu Thr
                  90                  95                 100

 tgg cca aga aag ctt cct gtt gaa caa ttt tat tat ttg acc cag aac      691
 Trp Pro Arg Lys Leu Pro Val Glu Gln Phe Tyr Tyr Leu Thr Gln Asn
             105                 110                 115

 aaa aaa agt gat gtc tat gga aat gat tct ttg ata ccc aag ccg cct      739
 Lys Lys Ser Asp Val Tyr Gly Asn Asp Ser Leu Ile Pro Lys Pro Pro
         120                 125                 130

 aat tca aca gta gga gag atc tgc ttg cca tat cca att gaa cac ccc      787
 Asn Ser Thr Val Gly Glu Ile Cys Leu Pro Tyr Pro Ile Glu His Pro
     135                 140                 145

 tac cac aca cac atc tgt cgc ggc acc atg ttc ccc acc ttc acg tca      835
 Tyr His Thr His Ile Cys Arg Gly Thr Met Phe Pro Thr Phe Thr Ser
 150                 155                 160                 165

 cct gag gac ctc tac acg ggc att aaa gcc cgc acc cag cag ccc ttt      883
 Pro Glu Asp Leu Tyr Thr Gly Ile Lys Ala Arg Thr Gln Gln Pro Phe
                 170                 175                 180

 cct ccc acg gtg cca agc aag gct tat gat tca aca gtt ttg aag aca      931
 Pro Pro Thr Val Pro Ser Lys Ala Tyr Asp Ser Thr Val Leu Lys Thr
             185                 190                 195

 aga ggt aat cct tat aga tat gaa ctg att gat att ccc atg gat tca      979
 Arg Gly Asn Pro Tyr Arg Tyr Glu Leu Ile Asp Ile Pro Met Asp Ser
         200                 205                 210

 aag aag aaa gca ctg act tgg cca ggt caa ggt gta tat tat gat ttt     1027
 Lys Lys Lys Ala Leu Thr Trp Pro Gly Gln Gly Val Tyr Tyr Asp Phe
     215                 220                 225

 ccc aga ggt gtt gag aaa aat aag cca gta ttc tac cca aaa cct cct     1075
 Pro Arg Gly Val Glu Lys Asn Lys Pro Val Phe Tyr Pro Lys Pro Pro
 230                 235                 240                 245

 aaa acc ttc gct cct aac act tct tta aat tca tgg gac cct att tgc     1123
 Lys Thr Phe Ala Pro Asn Thr Ser Leu Asn Ser Trp Asp Pro Ile Cys
                 250                 255                 260

 tct gcc aaa gaa gcc aac ata caa aga aat ctt gag agg tcc cac tgg     1171
 Ser Ala Lys Glu Ala Asn Ile Gln Arg Asn Leu Glu Arg Ser His Trp
             265                 270                 275

 ctc act tcg tac act cat gat ttt aca ggt ctg ggg ccc atg gac ccc     1219
 Leu Thr Ser Tyr Thr His Asp Phe Thr Gly Leu Gly Pro Met Asp Pro
         280                 285                 290

 ctt gaa ctg gat gat tac cgt gaa aag atg gta gca gag tta aca cga     1267
 Leu Glu Leu Asp Asp Tyr Arg Glu Lys Met Val Ala Glu Leu Thr Arg
     295                 300                 305

 aag ata gga ttt gac cca gag ccg caa gaa aaa ttc cac cct gtc ttc     1315
 Lys Ile Gly Phe Asp Pro Glu Pro Gln Glu Lys Phe His Pro Val Phe
 310                 315                 320                 325

 aaa cct ccc aga ccg ttg gaa gga cga att gcc cga tta att cag aac     1363
 Lys Pro Pro Arg Pro Leu Glu Gly Arg Ile Ala Arg Leu Ile Gln Asn
                 330                 335                 340

 cga cgt tct ctg gag gct ata gtc cag caa aga cca cgt tcc tgt cca     1411
 Arg Arg Ser Leu Glu Ala Ile Val Gln Gln Arg Pro Arg Ser Cys Pro
             345                 350                 355

 gat tgt act cct aga gtt ttg tgt aat ttt cat acc ttt gta ccc agt     1459
 Asp Cys Thr Pro Arg Val Leu Cys Asn Phe His Thr Phe Val Pro Ser
         360                 365                 370

 tct aaa gaa atg gtg gca ctt agt gat aac ata cca gcc ggt gtg acc     1507
 Ser Lys Glu Met Val Ala Leu Ser Asp Asn Ile Pro Ala Gly Val Thr
     375                 380                 385

 cat aaa aac cag gat att gaa gag aag atc ata gaa gaa cag agc ttg     1555
 His Lys Asn Gln Asp Ile Glu Glu Lys Ile Ile Glu Glu Gln Ser Leu
 390                 395                 400                 405

 ctg tct acc tat gaa ctc cca tct tgt tac cca aca aaa gac cta act     1603
 Leu Ser Thr Tyr Glu Leu Pro Ser Cys Tyr Pro Thr Lys Asp Leu Thr
                 410                 415                 420

 agc att tat gac ata aag cca ttt cca aaa atc aca gat act aaa aag     1651
 Ser Ile Tyr Asp Ile Lys Pro Phe Pro Lys Ile Thr Asp Thr Lys Lys
             425                 430                 435

 aca gaa gat tta tac tgg aga cag cag tca cta aaa acc caa ccc aca     1699
 Thr Glu Asp Leu Tyr Trp Arg Gln Gln Ser Leu Lys Thr Gln Pro Thr
         440                 445                 450

 cct tac tgt aaa cca gac cac tgg att cac tat gaa aat ctt aaa tct     1747
 Pro Tyr Cys Lys Pro Asp His Trp Ile His Tyr Glu Asn Leu Lys Ser
     455                 460                 465

 ccc cta cgt gat cag tat aat atg tgt cca gac cct gtt agc ctt agt     1795
 Pro Leu Arg Asp Gln Tyr Asn Met Cys Pro Asp Pro Val Ser Leu Ser
 470                 475                 480                 485

 aaa cct agt gtt tta caa aat aaa caa gac acg gaa gct ttc act tta     1843
 Lys Pro Ser Val Leu Gln Asn Lys Gln Asp Thr Glu Ala Phe Thr Leu
                 490                 495                 500

 gaa cat ttt tta agt aag cca gaa gaa gag ttg ttc ttg aat atg gaa     1891
 Glu His Phe Leu Ser Lys Pro Glu Glu Glu Leu Phe Leu Asn Met Glu
             505                 510                 515

 aac aat gaa gaa aca aga cct gtt ctt ggt tgg att cct aga gct gga     1939
 Asn Asn Glu Glu Thr Arg Pro Val Leu Gly Trp Ile Pro Arg Ala Gly
         520                 525                 530

 gtg acc aaa cct cag acc aac ctg ctg gag ctt aag aac tct ttt tca     1987
 Val Thr Lys Pro Gln Thr Asn Leu Leu Glu Leu Lys Asn Ser Phe Ser
     535                 540                 545

 aaa act ggt gca caa aag cgt ttc cat aaa tca att cta gaa gac cat     2035
 Lys Thr Gly Ala Gln Lys Arg Phe His Lys Ser Ile Leu Glu Asp His
 550                 555                 560                 565

 aaa gac ctc agg gat aat gag cat tcg ggg atg aag cac caa ttc tat     2083
 Lys Asp Leu Arg Asp Asn Glu His Ser Gly Met Lys His Gln Phe Tyr
                 570                 575                 580

 ggc cat aat tcc tat tat ttc tat aat tga g atactcattc ttcccttcaa     2134
 Gly His Asn Ser Tyr Tyr Phe Tyr Asn 
             585                 590

 aacccagcct cttgcaagaa gctaaaaaat ataacagaat ttccttcgta ttgctggatt   2194

 ctgttttcta gattaaacca caaggacctt gttagtgagg tttacatttt caggaattta   2254

 agttagtatc tggttggagg aacccagaaa aggtgatgtt atgacttctt gaaaagttta   2314

 acaatttggc aataaaatat tagaactaga aaaatttata gtctttaatc tctcatcttc   2374

 agattataca aggaaatttt ccaaaatcac aaaaagcaat gtgtacaaca aagtttacat   2434

 cattgtttca ccaaaaaaaa ttgaaaagct ggaaagaact caaatgatca ataattaatg   2494

 aatgactata caaattatag tatcttaata aaaatgagaa cactgtccct ttaaaaaaaa   2554

 aaaaaaaaaa aaaaaattg                                                2573




      <210> 123
      <211> 525
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(525)

      <400> 123
  atg act cca tcc tcg ttg acg cca tcc gca aga tca agg acg acg ttg      48
  Met Thr Pro Ser Ser Leu Thr Pro Ser Ala Arg Ser Arg Thr Thr Leu
    1               5                  10                  15

 agt act atg ttg act cat ccc agg acc ccg act tcg agg aga acg agt       96
 Ser Thr Met Leu Thr His Pro Arg Thr Pro Thr Ser Arg Arg Thr Ser
              20                  25                  30

 ttc tct acg ata ccc gcc aac atg ggc cgc gtt cgc acc aaa acc gtg      144
 Phe Ser Thr Ile Pro Ala Asn Met Gly Arg Val Arg Thr Lys Thr Val
          35                  40                  45

 aag aag gcg gcc cgg gtc atc ata gaa aag tac tac acg cgc ctg ggc      192
 Lys Lys Ala Ala Arg Val Ile Ile Glu Lys Tyr Tyr Thr Arg Leu Gly
      50                  55                  60

 aac gac ttc cac acg aac aag cgc gtg tgc gag gag atc gcc att atc      240
 Asn Asp Phe His Thr Asn Lys Arg Val Cys Glu Glu Ile Ala Ile Ile
  65                  70                  75                  80

 ccc agc aaa aag ctc cgc aac aag ata gca ggt tac gtc acg cat ctg      288
 Pro Ser Lys Lys Leu Arg Asn Lys Ile Ala Gly Tyr Val Thr His Leu
                  85                  90                  95

 atg aag cga att cag aga ggc cca gta aga ggt atc tcc atc aag ctg      336
 Met Lys Arg Ile Gln Arg Gly Pro Val Arg Gly Ile Ser Ile Lys Leu
             100                 105                 110

 cag gag gag gag aga gaa agg aga gac aat tat gtt cct gag gtc tca      384
 Gln Glu Glu Glu Arg Glu Arg Arg Asp Asn Tyr Val Pro Glu Val Ser
         115                 120                 125

 gcc ttg gat cag gag att att gaa gta gat cct gac act aag gaa atg      432
 Ala Leu Asp Gln Glu Ile Ile Glu Val Asp Pro Asp Thr Lys Glu Met
     130                 135                 140

 ctg aag ctt ttg gac ttc ggc agt ctg tcc aac ctt cag gtc act cag      480
 Leu Lys Leu Leu Asp Phe Gly Ser Leu Ser Asn Leu Gln Val Thr Gln
 145                 150                 155                 160

 cct aca gtt ggg atg aat ttc aaa acg cct cgg gga cct gtt tga          525
 Pro Thr Val Gly Met Asn Phe Lys Thr Pro Arg Gly Pro Val 
                 165                 170





      <210> 124
      <211> 3463
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (371)..(3463)

      <400> 124
 aggaggagga gggtgagaga gaagctggga gagcagagaa aaggggccac cggtcgcccc     60

 cccgcttccc cgcacgcgct ctccagccgc ggccgcccgc ctgccgcggt caccccggcc    120

 tctgcctctg tcccccagtg atcggatcaa ggcgctgagc gaggccctgc ctgcggggcg    180

 gccatgcggc ggtgacagga gcgcgaccga cacgcacggg cccctcgccc cctctcgcct    240

 cccgtccgct cgccagctcc cctcagccga ggctgctccg cggcggccgc agcccgcgcg    300

 cggcccacac tcgcctcccc tcggcacccc cggccccgga gctgcctgga ggcggccgca    360

 ctcggggatc   atg gcc caa gtt gca atg tcc acc ctc ccc gtt gaa gat     409
              Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp
                1               5                  10

 gag gag tcc tcg gag agc agg atg gtg gtg aca ttc ctc atg tca gct      457
 Glu Glu Ser Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala
      15                  20                  25

 ctc gag tcc atg tgt aaa gaa ctg gcc aag tcc aaa gcc gaa gtg gcc      505
 Leu Glu Ser Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala
  30                  35                  40                  45

 tgc att gca gtg tat gaa aca gac gtg ttt gtc gtc gga act gaa aga      553
 Cys Ile Ala Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg
                  50                  55                  60

 gga cgt gct ttt gtc aat acc aga aag gat ttt caa aaa gat ttt gta      601
 Gly Arg Ala Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val
              65                  70                  75

 aaa tat tgt gtt gaa gaa gaa gaa aaa gct gca gag atg cat aaa atg      649
 Lys Tyr Cys Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met
          80                  85                  90

 aaa tct aca acc cag gca aat cgg atg agt gta gat gct gta gaa att      697
 Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile
      95                 100                 105

 gaa aca ctc aga aaa aca gtt gag gac tat ttc tgc ttt tgc tat ggg      745
 Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly
 110                 115                 120                 125

 aaa gct tta ggc aaa tcc aca gtg gta cct gta cca tat gag aag atg      793
 Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met
                 130                 135                 140

 ctg cga gac cag tcg gct gtg gta gtg cag ggg ctt ccg gaa ggt gtt      841
 Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val
             145                 150                 155

 gcc ttt aaa cac ccc gag aac tat gat ctt gca acc ctg aaa tgg att      889
 Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile
         160                 165                 170

 ttg gag aac aaa gca ggg att tca ttc atc att aag aga cct ttt tta      937
 Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu
     175                 180                 185

 gag cca aag aag cat gta ggt ggt cgt gtg atg gta aca gat gct gac      985
 Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp
 190                 195                 200                 205

 agg tca ata cta tct cca ggt gga agt tgt ggc ccc atc aaa gtg aaa     1033
 Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys
                 210                 215                 220

 act gaa ccc aca gaa gat tct ggc att tcc ctg gaa atg gca gct gtg     1081
 Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val
             225                 230                 235

 aca gta aag gaa gaa tca gaa gat cct gat tat tat caa tat aac att     1129
 Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile
         240                 245                 250

 caa gca ggc cct tct gaa act gat gat gtt gat gaa aaa cag ccc cta     1177
 Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu
     255                 260                 265

 tcg aag cct ttg caa gga agc cac cat tct tca gag ggc aat gaa ggc     1225
 Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly
 270                 275                 280                 285

 aca gaa atg gaa gta cca gca gaa gat tct act caa cat gtc cct tca     1273
 Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser
                 290                 295                 300

 gaa aca agt gag gac cct gaa gtt gag gtg act att gaa gat gat gat     1321
 Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp
             305                 310                 315

 tat tct cca ccg tct aag aga cca aag gcc aat gag cta ccg cag cca     1369
 Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro
         320                 325                 330

 cca gtc ccg gaa ccc gcc aat gct ggg aag cgg aaa gtg agg gag ttc     1417
 Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe
     335                 340                 345

 aac ttc gag aaa tgg aat gct cgc atc act gat cta cgt aaa caa gtt     1465
 Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val
 350                 355                 360                 365

 gaa gaa ttg ttt gaa agg aaa tat gct caa gcc ata aaa gcc aaa ggt     1513
 Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly
                 370                 375                 380

 ccg gtg acg atc ccg tac cct ctt ttc cag tct cat gtt gaa gat ctt     1561
 Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu
             385                 390                 395

 tat gta gaa gga ctt cct gaa gga att cct ttt aga agg cca tct act     1609
 Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr
         400                 405                 410

 tac gga att cct cgc ctg gag agg ata tta ctt gca aag gaa agg att     1657
 Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile
     415                 420                 425

 cgt ttt gtg att aag aaa cat gag ctt ctg aat tca aca cgt gaa gat     1705
 Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp
 430                 435                 440                 445

 tta cag ctt gat aag cca gct tca gga gta aag gaa gaa tgg tat gcc     1753
 Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala
                 450                 455                 460

 aga atc act aaa tta aga aag atg gtg gat cag ctt ttc tgc aaa aaa     1801
 Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys
             465                 470                 475

 ttt gcg gaa gcc ttg ggg agc act gaa gcc aag gct gta ccg tac caa     1849
 Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln
         480                 485                 490

 aaa ttt gag gca cac ccg aat gat ctg tac gtg gaa gga ctg cca gaa     1897
 Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu
     495                 500                 505

 aac att cct ttc cga agt ccc tca tgg tat gga atc cca agg ctg gaa     1945
 Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu
 510                 515                 520                 525

 aaa atc att caa gtg ggc aat cga att aaa ttt gtt att aaa aga cca     1993
 Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro
                 530                 535                 540

 gaa ctt ctg act cac agt acc act gaa gtt act cag cca aga acg aat     2041
 Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn
             545                 550                 555

 aca cca gtc aaa gaa gat tgg aat gtc aga att acc aag cta cgg aag     2089
 Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys
         560                 565                 570

 caa gtg gaa gag att ttt aat ttg aaa ttt gct caa gct ctt gga ctc     2137
 Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu
     575                 580                 585

 acc gag gca gta aaa gta cca tat cct gtg ttt gaa tca aac ccg gag     2185
 Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu
 590                 595                 600                 605

 ttc ttg tat gtg gaa ggc ttg cca gag ggg att ccc ttc cga agc cct     2233
 Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro
                 610                 615                 620

 acc tgg ttt gga att cca cga ctt gaa agg atc gtc cgc ggg agt aat     2281
 Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn
             625                 630                 635

 aaa atc aag ttc gtt gtt aaa aaa cct gaa cta gtt att tcc tac ttg     2329
 Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu
         640                 645                 650

 cct cct ggg atg gct agt aaa ata aac act aaa gct ttg cag tcc ccc     2377
 Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro
     655                 660                 665

 aaa aga cca cga agt cct ggg agt aat tca aag gtt cct gaa att gag     2425
 Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu
 670                 675                 680                 685

 gtc acc gtg gaa ggc cct aat aac aac aat cct caa acc tca gct gtt     2473
 Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val
                 690                 695                 700

 cga acc ccg acc cag act aac ggt tct aac gtt ccc ttc aag cca cga     2521
 Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg
             705                 710                 715

 ggg aga gag ttt tcc ttt gag gcc tgg aat gcc aaa atc acg gac cta     2569
 Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu
         720                 725                 730

 aaa cag aaa gtt gaa aat ctc ttc aat gag aaa tgt ggg gaa gct ctt     2617
 Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu
     735                 740                 745

 ggc ctt aaa caa gct gtg aag gtg ccg ttc gcg tta ttt gag tct ttc     2665
 Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe
 750                 755                 760                 765

 ccg gaa gac ttt tat gtg gaa ggc tta cct gag ggt gtg cca ttc cga     2713
 Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg
                 770                 775                 780

 aga cca tcg act ttt ggc att ccg agg ctg gag aag ata ctc aga aac     2761
 Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn
             785                 790                 795

 aaa gcc aaa att aag ttc atc att aaa aag ccc gaa atg ttt gag acg     2809
 Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr
         800                 805                 810

 gcg att aag gag agc acc tcc tct aag agc cct ccc aga aaa ata aat     2857
 Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn
     815                 820                 825

 tca tca ccc aat gtt aat act act gca tca ggt gtt gaa gac ctt aac     2905
 Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn
 830                 835                 840                 845

 atc att cag gtg aca att cca gat gat gat aat gaa aga ctc tcg aaa     2953
 Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys
                 850                 855                 860

 gtt gaa aaa gct aga cag cta aga gaa caa gtg aat gac ctc ttt agt     3001
 Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser
             865                 870                 875

 cgg aaa ttt ggt gaa gct att ggt atg ggt ttt cct gtg aaa gtt ccc     3049
 Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro
         880                 885                 890

 tac agg aaa atc aca att aac cct ggc tgt gtg gtg gtt gat ggc atg     3097
 Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met
     895                 900                 905

 ccc ccg ggg gtg tcc ttc aaa gcc ccc agc tac ctg gaa atc agc tcc     3145
 Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser
 910                 915                 920                 925

 atg aga agg atc tta gac tct gcc gag ttt atc aaa ttc acg gtc att     3193
 Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile
                 930                 935                 940

 aga cca ttt cca gga ctt gtg att aat aac cag ctg gtt gat cag agt     3241
 Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser
             945                 950                 955

 gag tca gaa ggc ccc gtg ata caa gaa tca gct gaa cca agc cag ttg     3289
 Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu
         960                 965                 970

 gaa gtt cca gcc aca gaa gca aaa cca tct gga tca cct aac agt cag     3337
 Glu Val Pro Ala Thr Glu Ala Lys Pro Ser Gly Ser Pro Asn Ser Gln
     975                 980                 985

 agg tca gta tct cag cgt gtg aat tat aga gga aat aca gag aga acc     3385
 Arg Ser Val Ser Gln Arg Val Asn Tyr Arg Gly Asn Thr Glu Arg Thr
 990                 995                1000                1005

 tct tcc act ttt act ttt cgt cca aat aaa atg cat ggt gta cca gaa     3433
 Ser Ser Thr Phe Thr Phe Arg Pro Asn Lys Met His Gly Val Pro Glu
                1010                1015                1020

 gtt gaa gat cgg gtt gag gat tgg ggc tag                             3463
 Val Glu Asp Arg Val Glu Asp Trp Gly 
            1025                1030





      <210> 125
      <211> 1481
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (234)..(491)

      <400> 125
 ggcaccggca gggcaggcag ctgcgcgcgg ctggagtcat gctatactga aaagacactt     60

 catcaagata actctgggag aagcagaaaa ccctgtgcca gggacaggaa agataggaga    120

 aagaaagttt atcagaattt tttaaacctg tctcagaaat aacaacatat tttaatcaga    180

 gatttgctga agcttcagag atcacctgcc aaacacaggc tgaacctgac agc   atg     236
                                                              Met
                                                                1

 tca cac cag gat gtt gct atg agg aca gat tca tca aaa atg act gac      284
 Ser His Gln Asp Val Ala Met Arg Thr Asp Ser Ser Lys Met Thr Asp
               5                  10                  15

 gtg gag tct ggg gtc gcc aat ttt gca tct tca gca agg gca ggc cgc      332
 Val Glu Ser Gly Val Ala Asn Phe Ala Ser Ser Ala Arg Ala Gly Arg
          20                  25                  30

 cgg aat gcc tta cca gac atc cag agt tca gct gcc aca gac gga acc      380
 Arg Asn Ala Leu Pro Asp Ile Gln Ser Ser Ala Ala Thr Asp Gly Thr
      35                  40                  45

 tca gat ttg ccc ctc aaa ctg gag gct ctc tcc gtg aag gaa gat gca      428
 Ser Asp Leu Pro Leu Lys Leu Glu Ala Leu Ser Val Lys Glu Asp Ala
  50                  55                  60                  65

 aaa gag aaa gat gaa aaa aca aca caa gac caa ttg gaa aag cct caa      476
 Lys Glu Lys Asp Glu Lys Thr Thr Gln Asp Gln Leu Glu Lys Pro Gln
                  70                  75                  80

 aat gaa gaa aaa tga aggctcataa tctatcaaga gtgctgaatt tctgcatgtt      531
 Asn Glu Glu Lys 
              85

 gaaagactta gtggttctgt tttcttgaga catttaatct ggtggtaact gtggtaacat    591

 tgcagcccta agcagcatgt gtatattaga taattgtgtt gtgatgcttc tcactttgat    651

 tgcaatgatg atgtccaagg taagctatta aaaggcaggt tacttccaaa tcgcactgaa    711

 ggaaaaggtt aagaataata catgatcaca gaaatgcata ccactgtctg taaacccaac    771

 aaaattcact gttctctttt ggatttattt agcctgatgt atttttaatt caatttttat    831

 ggtgatgggc aaatcattct tggtaaatgt aaatcaaaca tgattgattt aaaacttcat    891

 ggaatttgta gaaaattatg gacatttttg gtgagaaaga acaatagtca aaactcacat    951

 ggatagagtg tgtttgtttt ttgccaaaaa tgccccagac tttttcccaa acctcaaaaa   1011

 cgtcttggaa aaattgtaaa agtttgataa cagaaacatc tttaggatat ttttgtctga   1071

 cgtattttgc ttctagtatg tgcctactgt gatttttttc atgtggaaaa tgcaaaattt   1131

 gtaagccaaa aatgggctta atatgggaac catgcccctt aattaaaacc ggaatttttt   1191

 actaattctt tcccccaaga aactccaaaa ctaacaacac ctaacaacca aacaaactgt   1251

 ttgtgggcgc gccctgcgga ccctcaaaca agcacgtgtt tgagacaacc actggcgtgg   1311

 cgggacaccg ggcaccaccc gcgctgtacc gagcgaggat ccgtcgcaca acatcgtgtc   1371

 acccaaaaga cactcccggg ggccacgata catagaggca gcgacatctc cccccaagtg   1431

 caaaaaacgc ccgcgcggca acccaagcgg ttcataacaa attcacaggt              1481




      <210> 126
      <211> 845
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (180)..(527)

      <400> 126
 cggacgcgtg ggtaaaatcc tgctgtggcc ggattccaga ctcgtggggg aaaggctgtt     60

 tccaaggcag gaaaggtaaa gagacaaaga aagtgccttg tacagatgca aacggaggtg    120

 tagactgtgc agctgccaaa gtggtgacaa gcaatccaga ggaccatgaa aggatctta     179                                                                 
 atg caa gtc atg aac ttg aat gtg ccg atg agg cct ggc att ctt gtc      227
 Met Gln Val Met Asn Leu Asn Val Pro Met Arg Pro Gly Ile Leu Val
   1               5                  10                  15

 cag aga cag agt aag gaa gtg ttg gcc aca ccc tta gaa aac aga agg      275
 Gln Arg Gln Ser Lys Glu Val Leu Ala Thr Pro Leu Glu Asn Arg Arg
              20                  25                  30

 gac atg gag gca gaa gag gag aac caa ata aat gag aag caa gag cct      323
 Asp Met Glu Ala Glu Glu Glu Asn Gln Ile Asn Glu Lys Gln Glu Pro
          35                  40                  45

 gag aat gct gga gaa act ggt caa gaa gag gat gat ggt ttg cag aaa      371
 Glu Asn Ala Gly Glu Thr Gly Gln Glu Glu Asp Asp Gly Leu Gln Lys
      50                  55                  60

 ata cac aca tct gtc act aga act cct tca gtt gtt gaa agc caa aaa      419
 Ile His Thr Ser Val Thr Arg Thr Pro Ser Val Val Glu Ser Gln Lys
  65                  70                  75                  80

 aga cct tta aaa gga gtg aca ttt tct agg gag gta att gtt gtg gat      467
 Arg Pro Leu Lys Gly Val Thr Phe Ser Arg Glu Val Ile Val Val Asp
                  85                  90                  95

 ctt ggg aat gaa tac cct aca cct cga agc tat act cga gaa cat aaa      515
 Leu Gly Asn Glu Tyr Pro Thr Pro Arg Ser Tyr Thr Arg Glu His Lys
             100                 105                 110

 gag agg aaa tga agc tcaaaaaagg gtaagagtga aagaaaatgt aacgtttgac      570
 Glu Arg Lys 
         115

 taacgttgaa agactgaggg tacaaaatca tgttgaaaca acaaaacaat ggggaattaa    630

 gcaaataaag atattatttt acctttgtgc agaaaggagt gagccatgtg caaaattctg    690

 taagtaaaat acttagagct tgaatataat tttttaaaaa ttcaaatctg agttcaagaa    750

 attgattgta ttgcccttaa aactatctac tcaaacactg ttctggcatg tgaataaagt    810

 gatttttgtt tgtacaaata aaaaaaaaaa aaaag                               845




      <210> 127
      <211> 536
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (7)..(486)

      <400> 127
 ggcagg   atg gag atc ctg tgc ctg tgc agc cgt ctt ggc cgc cgc gcc      48
          Met Glu Ile Leu Cys Leu Cys Ser Arg Leu Gly Arg Arg Ala
            1               5                  10

 tcg gcc ccg ttg ccc gga ctt tcg gcg ccc gga cgc ctc ttt gac cag       96
 Ser Ala Pro Leu Pro Gly Leu Ser Ala Pro Gly Arg Leu Phe Asp Gln
  15                  20                  25                  30

 cgc ttc ggc gag ggg ctg ctg gag gcc gag ctg gct gcg ctc tgc ccc      144
 Arg Phe Gly Glu Gly Leu Leu Glu Ala Glu Leu Ala Ala Leu Cys Pro
                  35                  40                  45

 acc acg ctc gcc ccc tac tac ctg cgc gca ccc agc gtg gcg ctg ccc      192
 Thr Thr Leu Ala Pro Tyr Tyr Leu Arg Ala Pro Ser Val Ala Leu Pro
              50                  55                  60

 gtc gcc cag gtg ccg acg gac ccc ggc cac ttt tcg gtg ctg cta gac      240
 Val Ala Gln Val Pro Thr Asp Pro Gly His Phe Ser Val Leu Leu Asp
          65                  70                  75

 gtg aag cac ttc tcg ccg gag gaa att gct gtc aag gtg gtg ggc gaa      288
 Val Lys His Phe Ser Pro Glu Glu Ile Ala Val Lys Val Val Gly Glu
      80                  85                  90

 cac gtg gag gtg cac gcg cgc cac gag gag cgc ccg gat gag cac gga      336
 His Val Glu Val His Ala Arg His Glu Glu Arg Pro Asp Glu His Gly
  95                 100                 105                 110

 ttc gtc gcg cgc gag ttc cac cgt cgc tac cgc ctg ccg cct ggc gtg      384
 Phe Val Ala Arg Glu Phe His Arg Arg Tyr Arg Leu Pro Pro Gly Val
                 115                 120                 125

 gat ccg gct gcc gtg acg tcc gcg ctg tcc ccc gag ggc gtc ctg tcc      432
 Asp Pro Ala Ala Val Thr Ser Ala Leu Ser Pro Glu Gly Val Leu Ser
             130                 135                 140

 atc cag gcc gca cca gcg tcg gcc cag gcc cca ccg cca gcc gca gcc      480
 Ile Gln Ala Ala Pro Ala Ser Ala Gln Ala Pro Pro Pro Ala Ala Ala
         145                 150                 155

 aag tag gagggggctg ggccgcgccc gcaccccggg agcctcctca ggctccctct       536
 Lys 






      <210> 128
      <211> 1500
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1500)

      <400> 128
  atg gtg gag aag aag gaa ccc tat agt cga gcc tct gga cac cct ggt      48
  Met Val Glu Lys Lys Glu Pro Tyr Ser Arg Ala Ser Gly His Pro Gly
    1               5                  10                  15

 cta ggt ggc cac tca gga tca gtg cag ggg gcc tgc aca cca cta ggg       96
 Leu Gly Gly His Ser Gly Ser Val Gln Gly Ala Cys Thr Pro Leu Gly
              20                  25                  30

 gca aca cac tca agg cca aat tat aca aga aaa aga gat acc aga tct      144
 Ala Thr His Ser Arg Pro Asn Tyr Thr Arg Lys Arg Asp Thr Arg Ser
          35                  40                  45

 gaa agc cta gaa att cca atc agt gtg gtt cta cct cag ctc cca gaa      192
 Glu Ser Leu Glu Ile Pro Ile Ser Val Val Leu Pro Gln Leu Pro Glu
      50                  55                  60

 aca gcc caa cga tca agg aga aga gaa ggt ggt tta aga cag ctc aag      240
 Thr Ala Gln Arg Ser Arg Arg Arg Glu Gly Gly Leu Arg Gln Leu Lys
  65                  70                  75                  80

 ctt gtc ttg ggg ctg cct gct tcc tgt gct gga gga cct ggt gct gct      288
 Leu Val Leu Gly Leu Pro Ala Ser Cys Ala Gly Gly Pro Gly Ala Ala
                  85                  90                  95

 gct ggg gtc ttg tgg ggc aga agg ggc aca gcc gaa ccc ttc ccg agg      336
 Ala Gly Val Leu Trp Gly Arg Arg Gly Thr Ala Glu Pro Phe Pro Arg
             100                 105                 110

 ctc cac aac ttg tac agc acc cct cgc tgc gcg cag cag gcc gcc ctg      384
 Leu His Asn Leu Tyr Ser Thr Pro Arg Cys Ala Gln Gln Ala Ala Leu
         115                 120                 125

 ccc cgg ctg agc cgc agg atg gcg agc cag cac tcc tat cca ctg aac      432
 Pro Arg Leu Ser Arg Arg Met Ala Ser Gln His Ser Tyr Pro Leu Asn
     130                 135                 140

 cgc ttc tcc tcc gtg cct tta gac ccc atg gag cgc ccc atg tcc cag      480
 Arg Phe Ser Ser Val Pro Leu Asp Pro Met Glu Arg Pro Met Ser Gln
 145                 150                 155                 160

 gcc gac ctg gag ctg gac tac aac ccg ccg cgg gtg cag ctc agc gac      528
 Ala Asp Leu Glu Leu Asp Tyr Asn Pro Pro Arg Val Gln Leu Ser Asp
                 165                 170                 175

 gag atg ttc gtg ttc cag gac ggg cgc tgg gta aat gag aac tgc cgc      576
 Glu Met Phe Val Phe Gln Asp Gly Arg Trp Val Asn Glu Asn Cys Arg
             180                 185                 190

 ctg cag tct ccc tac ttc tcc cca tcc gcc tcc ttc cac cac aag ctg      624
 Leu Gln Ser Pro Tyr Phe Ser Pro Ser Ala Ser Phe His His Lys Leu
         195                 200                 205

 cac cac aag agg ctg gcc aag gag tgc atg ctg cag gag gag aac aag      672
 His His Lys Arg Leu Ala Lys Glu Cys Met Leu Gln Glu Glu Asn Lys
     210                 215                 220

 tct ctg cgg gag gag aac aag gcc ctg cgc gag gag aac cgg atg ctc      720
 Ser Leu Arg Glu Glu Asn Lys Ala Leu Arg Glu Glu Asn Arg Met Leu
 225                 230                 235                 240

 agc aag gag aac aag atc cta cag gtc ttc tgg gag gag cac aag gcc      768
 Ser Lys Glu Asn Lys Ile Leu Gln Val Phe Trp Glu Glu His Lys Ala
                 245                 250                 255

 tcg ctg ggc cga gag gag agc cgg gcc ccc tcg cca ctg ctg cac aaa      816
 Ser Leu Gly Arg Glu Glu Ser Arg Ala Pro Ser Pro Leu Leu His Lys
             260                 265                 270

 gac agc gcg tcc ctg gag gtg gtg aag aag gac cac gtc gcc ctg cag      864
 Asp Ser Ala Ser Leu Glu Val Val Lys Lys Asp His Val Ala Leu Gln
         275                 280                 285

 gtg ccc cgt ggc aag gag gac agc acc ctg cag ctc ctc cgg gag gag      912
 Val Pro Arg Gly Lys Glu Asp Ser Thr Leu Gln Leu Leu Arg Glu Glu
     290                 295                 300

 aat cgc gcg ctg cag cag ctg ctg gag cag aaa cag gcc tac tgg gcg      960
 Asn Arg Ala Leu Gln Gln Leu Leu Glu Gln Lys Gln Ala Tyr Trp Ala
 305                 310                 315                 320

 cag gca gag gac acg gcc gcc cct gcc gag gaa agc aag ccc gcc ccc     1008
 Gln Ala Glu Asp Thr Ala Ala Pro Ala Glu Glu Ser Lys Pro Ala Pro
                 325                 330                 335

 tca ccc cac gag gag ccc tgc agc ccc ggg ctg ctg cag gac cag ggc     1056
 Ser Pro His Glu Glu Pro Cys Ser Pro Gly Leu Leu Gln Asp Gln Gly
             340                 345                 350

 tcc ggc ctc tcc tcc cgc ttc gag gag ccc aaa ggg cct ccg gcc cgg     1104
 Ser Gly Leu Ser Ser Arg Phe Glu Glu Pro Lys Gly Pro Pro Ala Arg
         355                 360                 365

 cag gag gac tcc aag gag ctg cgc gcc ctg cgg aag atg gtc agc aac     1152
 Gln Glu Asp Ser Lys Glu Leu Arg Ala Leu Arg Lys Met Val Ser Asn
     370                 375                 380

 atg tcc ggg ccc tcc ggg gag gag gag gcc aag gtg ggc ccg ggc ctg     1200
 Met Ser Gly Pro Ser Gly Glu Glu Glu Ala Lys Val Gly Pro Gly Leu
 385                 390                 395                 400

 ccc gac ggc tgc cag ccc ctg cag ctg ctg aga gag atg agg cag gcg     1248
 Pro Asp Gly Cys Gln Pro Leu Gln Leu Leu Arg Glu Met Arg Gln Ala
                 405                 410                 415

 ctg cag gcc ctg ctc aag gag aac cgg ctc ctg cag gag gag aac agg     1296
 Leu Gln Ala Leu Leu Lys Glu Asn Arg Leu Leu Gln Glu Glu Asn Arg
             420                 425                 430

 acc ctg cag gtg cta cgg gca gag cac agg ggc ttc cag gag gag aac     1344
 Thr Leu Gln Val Leu Arg Ala Glu His Arg Gly Phe Gln Glu Glu Asn
         435                 440                 445

 aag gcc ctg tgg gag aac aac aag ctg aag ctg cag cag aag ctg gtc     1392
 Lys Ala Leu Trp Glu Asn Asn Lys Leu Lys Leu Gln Gln Lys Leu Val
     450                 455                 460

 att gac acc gtg acc gag gtc acc gcg cgc atg gaa atg ctc atc gag     1440
 Ile Asp Thr Val Thr Glu Val Thr Ala Arg Met Glu Met Leu Ile Glu
 465                 470                 475                 480

 gag ctc tac gcc ttc atg ccg gcc agg agc cag gac ccc aag aag cct     1488
 Glu Leu Tyr Ala Phe Met Pro Ala Arg Ser Gln Asp Pro Lys Lys Pro
                 485                 490                 495

 agc agg gtc tga                                                     1500
 Ser Arg Val 






      <210> 129
      <211> 762
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(762)

      <400> 129
  atg atg atg ggt tgt ggg gag tca gag ctg aag tcg gcg gac ggg gaa      48
  Met Met Met Gly Cys Gly Glu Ser Glu Leu Lys Ser Ala Asp Gly Glu
    1               5                  10                  15

 gaa gcc gcg gcg gtc ccg ggg cca ccc ccg gag ccc caa gtc ccg caa       96
 Glu Ala Ala Ala Val Pro Gly Pro Pro Pro Glu Pro Gln Val Pro Gln
              20                  25                  30

 ctc cga gcc cca gtg ccc gag ccc ggc ctg gac ttg agc ctg agc ccg      144
 Leu Arg Ala Pro Val Pro Glu Pro Gly Leu Asp Leu Ser Leu Ser Pro
          35                  40                  45

 cgg ccc gac agc cct cag ccg cgg cac ggc agc ccc ggg cgg cgg aag      192
 Arg Pro Asp Ser Pro Gln Pro Arg His Gly Ser Pro Gly Arg Arg Lys
      50                  55                  60

 ggg cgg gcg gag cgg cgg ggc gcg gct cgg cag cgg cgg cag gtc cgc      240
 Gly Arg Ala Glu Arg Arg Gly Ala Ala Arg Gln Arg Arg Gln Val Arg
  65                  70                  75                  80

 ttc cgc ctg acg ccg ccc tcc ccg gtg cgg tcc gag ccg cag cct gcg      288
 Phe Arg Leu Thr Pro Pro Ser Pro Val Arg Ser Glu Pro Gln Pro Ala
                  85                  90                  95

 gtg ccg cag gag ctg gag atg ccc gtg ctg aag agc agc ctg gcc ttg      336
 Val Pro Gln Glu Leu Glu Met Pro Val Leu Lys Ser Ser Leu Ala Leu
             100                 105                 110

 ggc ctg gag ctg cgg gcc gca gcc ggg agc cac ttt gat gct gcg aag      384
 Gly Leu Glu Leu Arg Ala Ala Ala Gly Ser His Phe Asp Ala Ala Lys
         115                 120                 125

 gcc gtg gag gaa cag ctg aga aag tcg ttc cag atc cgc tgc ggc ctg      432
 Ala Val Glu Glu Gln Leu Arg Lys Ser Phe Gln Ile Arg Cys Gly Leu
     130                 135                 140

 gag gag agc gtg tcc gag ggg ctg aac gtg ccg cgc tcc aag cgg ctc      480
 Glu Glu Ser Val Ser Glu Gly Leu Asn Val Pro Arg Ser Lys Arg Leu
 145                 150                 155                 160

 ttc cgg gac ctg gtg agc ctg cag gtg ccg gag gaa cag gtt ctg aat      528
 Phe Arg Asp Leu Val Ser Leu Gln Val Pro Glu Glu Gln Val Leu Asn
                 165                 170                 175

 gcc gcg ctc agg gag aaa ttg gct ctc ctg ccg cca cag gct cga gcc      576
 Ala Ala Leu Arg Glu Lys Leu Ala Leu Leu Pro Pro Gln Ala Arg Ala
             180                 185                 190

 ccg cac cca aag gag cca cct ggg cct ggg cca gac atg acc atc ttg      624
 Pro His Pro Lys Glu Pro Pro Gly Pro Gly Pro Asp Met Thr Ile Leu
         195                 200                 205

 tgt gac cca gaa acg cta ttt tat gaa tct cca cac ctg acc ctg gac      672
 Cys Asp Pro Glu Thr Leu Phe Tyr Glu Ser Pro His Leu Thr Leu Asp
     210                 215                 220

 ggt ctg ccc cct ctc cga ctt caa ctc cgg ccc cgc cct tca gag gac      720
 Gly Leu Pro Pro Leu Arg Leu Gln Leu Arg Pro Arg Pro Ser Glu Asp
 225                 230                 235                 240

 acc ttc ctc atg cac cgg aca ctg agg cga tgg gaa gcg tag              762
 Thr Phe Leu Met His Arg Thr Leu Arg Arg Trp Glu Ala 
                 245                 250





      <210> 130
      <211> 3477
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (124)..(1704)

      <400> 130
 agcgggcgcg tgagaaggtg gcggtgtagg cacctgcgct cggggaaggc tggcggcggc     60

 ggccgggcca tggccagaga ccccctcctc tgggctccct gaagtcctgg ggagccgtga    120

 ccc  atg gga tcg tcg agc agc cgg gtg ctg ggc cag ccg agg cga gcc     168
      Met Gly Ser Ser Ser Ser Arg Val Leu Gly Gln Pro Arg Arg Ala
        1               5                  10                  15

 ctt gcc cag cag gaa cag ggt gcc agg gcc agg ggc tcg gcc cgg agg      216
 Leu Ala Gln Gln Glu Gln Gly Ala Arg Ala Arg Gly Ser Ala Arg Arg
                  20                  25                  30

 ccg gac act gga gac gat gcg gcg agc tac ggc ttc tgt tac tgc ccg      264
 Pro Asp Thr Gly Asp Asp Ala Ala Ser Tyr Gly Phe Cys Tyr Cys Pro
              35                  40                  45

 ggc agt cac aag cgc aag cgg agc agc ggg gcc tgc cgc tac tgt gac      312
 Gly Ser His Lys Arg Lys Arg Ser Ser Gly Ala Cys Arg Tyr Cys Asp
          50                  55                  60

 ccg gac tcg cac agg gag gag cat gag gag gag ggg gac aag cag cag      360
 Pro Asp Ser His Arg Glu Glu His Glu Glu Glu Gly Asp Lys Gln Gln
      65                  70                  75

 ccg ctc ctc aac acc cct gca agg aaa aaa tta agg agt aca tcc aaa      408
 Pro Leu Leu Asn Thr Pro Ala Arg Lys Lys Leu Arg Ser Thr Ser Lys
  80                  85                  90                  95

 tat att tat caa aca tta ttt ttg aat ggt gaa aac agt gac att aag      456
 Tyr Ile Tyr Gln Thr Leu Phe Leu Asn Gly Glu Asn Ser Asp Ile Lys
                 100                 105                 110

 att tgt gct cta gga gaa gaa tgg cga tta cac aaa ata tat tta tgt      504
 Ile Cys Ala Leu Gly Glu Glu Trp Arg Leu His Lys Ile Tyr Leu Cys
             115                 120                 125

 caa tct ggc tac ttt tct agt atg ttc agt ggt tct tgg aaa gaa tcc      552
 Gln Ser Gly Tyr Phe Ser Ser Met Phe Ser Gly Ser Trp Lys Glu Ser
         130                 135                 140

 agc atg aat att att gaa ctg gag att cct gac cag aac att gat gta      600
 Ser Met Asn Ile Ile Glu Leu Glu Ile Pro Asp Gln Asn Ile Asp Val
     145                 150                 155

 gac gca ctg cag gtt gcg ttt ggt tca ctg tat cga gat gat gtc ttg      648
 Asp Ala Leu Gln Val Ala Phe Gly Ser Leu Tyr Arg Asp Asp Val Leu
 160                 165                 170                 175

 ata aaa ccc agt cga gtt gtt gcc att ttg gca gca gct tgt atg ctg      696
 Ile Lys Pro Ser Arg Val Val Ala Ile Leu Ala Ala Ala Cys Met Leu
                 180                 185                 190

 cag ctg gat ggt tta ata cag cag tgt ggt gag aca atg aag gaa aca      744
 Gln Leu Asp Gly Leu Ile Gln Gln Cys Gly Glu Thr Met Lys Glu Thr
             195                 200                 205

 att aat gtg aaa act gta tgc ggt tat tac aca tca gta gag atc tat      792
 Ile Asn Val Lys Thr Val Cys Gly Tyr Tyr Thr Ser Val Glu Ile Tyr
         210                 215                 220

 gga tta gat tct gta aag aaa aag tgc ctt gaa tgg ctt cta aac aat      840
 Gly Leu Asp Ser Val Lys Lys Lys Cys Leu Glu Trp Leu Leu Asn Asn
     225                 230                 235

 ttg atg act cac cag aat gtt aaa ctt ttt aaa gaa ctc ggt ata aat      888
 Leu Met Thr His Gln Asn Val Lys Leu Phe Lys Glu Leu Gly Ile Asn
 240                 245                 250                 255

 gtc atg aaa cag ctc att ggt tcc tct aac tta ttt gtg atg caa gtg      936
 Val Met Lys Gln Leu Ile Gly Ser Ser Asn Leu Phe Val Met Gln Val
                 260                 265                 270

 gag atg gat gta tac acc act cta aaa aag tgg atg ttc ctt caa ctt      984
 Glu Met Asp Val Tyr Thr Thr Leu Lys Lys Trp Met Phe Leu Gln Leu
             275                 280                 285

 gtg cct tct tgg aat gga tct tta aaa cag ctt ttg aca gaa aca gat     1032
 Val Pro Ser Trp Asn Gly Ser Leu Lys Gln Leu Leu Thr Glu Thr Asp
         290                 295                 300

 gtc tgg ttt tct aaa cag aga aaa gat ttt gaa ggt atg gcc ttt ctt     1080
 Val Trp Phe Ser Lys Gln Arg Lys Asp Phe Glu Gly Met Ala Phe Leu
     305                 310                 315

 gaa act gaa cca gga aaa cca ttt gtg tca gta ttc aga cat tta agg     1128
 Glu Thr Glu Pro Gly Lys Pro Phe Val Ser Val Phe Arg His Leu Arg
 320                 325                 330                 335

 tta caa tat att atc agt gac cta gct tct gca aga att att gaa caa     1176
 Leu Gln Tyr Ile Ile Ser Asp Leu Ala Ser Ala Arg Ile Ile Glu Gln
                 340                 345                 350

 gat ggt ata gta cct tca gaa tgg ctg tct tct gtg tat aaa cag cag     1224
 Asp Gly Ile Val Pro Ser Glu Trp Leu Ser Ser Val Tyr Lys Gln Gln
             355                 360                 365

 tgg ttt gct atg ctg cgg gca gaa caa gac cat gag gta ggg cct caa     1272
 Trp Phe Ala Met Leu Arg Ala Glu Gln Asp His Glu Val Gly Pro Gln
         370                 375                 380

 gaa atc aat aaa gaa gac cta gag gga agt agc atg agg tgt ggt aga     1320
 Glu Ile Asn Lys Glu Asp Leu Glu Gly Ser Ser Met Arg Cys Gly Arg
     385                 390                 395

 aag ctt gcc aaa gat ggt gaa tac tac tgg tgt tgg acg ggt ttt aac     1368
 Lys Leu Ala Lys Asp Gly Glu Tyr Tyr Trp Cys Trp Thr Gly Phe Asn
 400                 405                 410                 415

 ttc ggc ttt gac cta ctt gta att tac acc aat gga tac atc att ttc     1416
 Phe Gly Phe Asp Leu Leu Val Ile Tyr Thr Asn Gly Tyr Ile Ile Phe
                 420                 425                 430

 aaa cgc aat aca ctg aat cag cca tgc agc ggg tct gtc agt tta cgg     1464
 Lys Arg Asn Thr Leu Asn Gln Pro Cys Ser Gly Ser Val Ser Leu Arg
             435                 440                 445

 cct cga agg agc ata gca ttt aga tta cgc ttg gct tct ttt gat agt     1512
 Pro Arg Arg Ser Ile Ala Phe Arg Leu Arg Leu Ala Ser Phe Asp Ser
         450                 455                 460

 agt gga aaa cta gta tgt agt aga aca act ggc tat caa ata ctt ata     1560
 Ser Gly Lys Leu Val Cys Ser Arg Thr Thr Gly Tyr Gln Ile Leu Ile
     465                 470                 475

 ctt aaa aag gat cag gaa caa gtg gtg atg aac ttg gac agc agg ttt     1608
 Leu Lys Lys Asp Gln Glu Gln Val Val Met Asn Leu Asp Ser Arg Phe
 480                 485                 490                 495

 ctg acc ttc cct tta tat atc tgc tgt aac ttc ttg tat ata tca cca     1656
 Leu Thr Phe Pro Leu Tyr Ile Cys Cys Asn Phe Leu Tyr Ile Ser Pro
                 500                 505                 510

 gaa aaa gga att gaa aat aat cgc cac cca gaa gat cca gaa aac tga     1704
 Glu Lys Gly Ile Glu Asn Asn Arg His Pro Glu Asp Pro Glu Asn 
             515                 520                 525

 agatctcatc agttggaaac agtagcactt tgaaaacttt caggccagct ttaatttaat   1764

 ggccctactg atattcacat ctaaggtgac taacaatgac aaaggcctta tgaactgtac   1824

 ggacaataca gaagactatt cttatcctca ttgcatttct atgcatatac aaaaaaaacc   1884

 attttaaagc caagaaaata tctgtcaaac cctttctgtc agtacgatgt caactcatgc   1944

 ttttaattta gcatcagcag aaaattgctg taggtaaatc tcacatttat ctgcaacaaa   2004

 atatagattt aatttttagc ttaaactttg tttctacctt atgttagtgg acctcagtta   2064

 tccatctgta aatttctttt tatttggcta aaataatcta aaagaataat ttggttggcc   2124

 aattagaaat gcctttttca gttggtgtat tgaaagcttt cctttaacat tttcacctgc   2184

 tcattgtgat tcctcctttt agtctaatat ctttccaggt catacttgtt tttaatcatt   2244

 aaatattttc ttcctggttt tggagactaa gctgataaac tttttttaaa acttaagcat   2304

 tgtcattgct atttttttta atttgacttt cctaggagtt taagaacagt gaaagttagc   2364

 ttcgcacctt caaatgatct tgaatgaggg aaaaatcagt ttgattccaa ggatatttct   2424

 tgccttacat ggtcttttct ttgacagtct gtacaccttt attattaggt tttgaattat   2484

 ttatgtacca gatattatag ttttaaacat tttaatattc tctgatcttt agaattattt   2544

 atgttcaaat tttagttggg aactttgttt cctacttaag ctcaggactt tttaccctct   2604

 gaattgagtg cctttgagtg acacatgcta atagaaattt catagtaaat gtaaataagg   2664

 tcagaggatg taatatggag cctgatgatg aagcattaat gtaaaaatgg aacttatttt   2724

 tgtcaaaaat gagatgtaca cttgtcatga tttatgtatg ttgacctttt gtgtttatta   2784

 ctgttttgaa aatagccatg ttcattttct ttccagttag agtaagtact tctggggggc   2844

 accggctcat cccccccctc gcgggtctct ccctcggggc cctcccccgg catctccggg   2904

 cgcaatataa aggcccccct gccgcaccaa cacacacacc cccaaaaacc acgtctcgcg   2964

 ccaccaccgc ccccacacac cctcacaccc acacgtggcg gccccacaaa acacacgcac   3024

 accccccaca caccacacca caacacagga ggtcccacac accacgcccg cgggcacacc   3084

 aagacgatgc aagcgccata ctaacagaca cgaccacaac cctacagcac acgccccagc   3144

 accgcgccgc agcgccacac tcaccagcac aaacaactac acccgcgacc gccacgcccg   3204

 cacccagcac cgcgtcagcg acagccgaac caacgacatg ccggtgtggt ggggggtgag   3264

 tggtggtgcg tgggcggggg gtgggcgggg ggagaggccg cagcggcggg ctgcgtagga   3324

 gaggcactga tcagagaggc agagcgcgca tagggcagca gggcgcgcag ccgacggccc   3384

 ccgtcgcagt cagtgccgca cgacggagac agttcacgac gcgacaacgc gccgcgacgc   3444

 gcctgccgcc gtacgcggcc catcgagagc cac                                3477




      <210> 131
      <211> 1015
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (572)..(1015)

      <400> 131
 gtggctttgg cctttgttga ctgttggacc tggacagaac agggctatct tgattgtgga     60

 atgggcaagt ctgatctgaa caccctcctg tctgctgcca tctcccagca tccctgcatg    120

 gccacacctg tttgcagcgc agcctcagat gccaaactgg tgcacttcct ggtggctgct    180

 gccatagctc cttcactggc aggcccagct aaccatcaga ggaccccttg ccacagcccc    240

 aatgaaatgc ttttgccagc atcctcctcc cctattggag tattgttagt ggaatggaaa    300

 cacctcagcc cctccagcac agtagatgct caactcgagg gtccagagaa caaagccatg    360

 gccctggtcc tagtccccca ctgttacagc atgcagccca ggggtgctga gctgagcctt    420

 ggccacttga aattatccag aaatgaagcc agtcaactga acccaactta taccacagtc    480

 aaaccctcaa gggcatcaaa gaatataaaa gcaaaaaacc ccatccaaag gacagcaact    540

 tcaaagatta aaggaacatc agcccacaca g   atg aga aag aac cag cac aag     592
                                      Met Arg Lys Asn Gln His Lys
                                        1               5

 aac tct ggc aac tca aaa agc cag agt gtc ttc tta cct cca aat gac      640
 Asn Ser Gly Asn Ser Lys Ser Gln Ser Val Phe Leu Pro Pro Asn Asp
          10                  15                  20

 cac act agc tcc cca gca atg gtt ctt aac cag gct gaa atg gct gaa      688
 His Thr Ser Ser Pro Ala Met Val Leu Asn Gln Ala Glu Met Ala Glu
      25                  30                  35

 atg aca gac ata gaa ttc aga atc tgg atg gca atg aag atc atc gag      736
 Met Thr Asp Ile Glu Phe Arg Ile Trp Met Ala Met Lys Ile Ile Glu
  40                  45                  50                  55

 att cag gag aaa gtt gaa acc caa tcc aag gaa tct aag gaa tcc agt      784
 Ile Gln Glu Lys Val Glu Thr Gln Ser Lys Glu Ser Lys Glu Ser Ser
                  60                  65                  70

 aaa atg ata caa gag ctg aaa gat gaa ata gcc att tta aga aag aac      832
 Lys Met Ile Gln Glu Leu Lys Asp Glu Ile Ala Ile Leu Arg Lys Asn
              75                  80                  85

 caa act gat ctg ata gag ctg aaa aac tca ctt caa gaa ttt cag aat      880
 Gln Thr Asp Leu Ile Glu Leu Lys Asn Ser Leu Gln Glu Phe Gln Asn
          90                  95                 100

 aca att gca agt att aac agc aga att gac caa gct gag gaa aga atc      928
 Thr Ile Ala Ser Ile Asn Ser Arg Ile Asp Gln Ala Glu Glu Arg Ile
     105                 110                 115

 tca gag ctt gaa gac tgg ctc tct gaa ata act cag aca aca acc acc      976
 Ser Glu Leu Glu Asp Trp Leu Ser Glu Ile Thr Gln Thr Thr Thr Thr
 120                 125                 130                 135

 aca aca aaa agt aaa cac aag aat gaa cga aag ctc tga                 1015
 Thr Thr Lys Ser Lys His Lys Asn Glu Arg Lys Leu 
                 140                 145





      <210> 132
      <211> 1000
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (96)..(758)

      <400> 132
 ctatatccaa ttggcgtagc gcttgctgag cggcggcggc aaccgacgta cacaaggggc     60

 ttgagcgttc tgtggagaga gtgcgaggtc aggcc   atg aac ttg gga gat ggt     113
                                          Met Asn Leu Gly Asp Gly
                                            1               5

 tta aag ctt gaa act gaa tta ctg gat gga aaa acc aag cta ata ttg      161
 Leu Lys Leu Glu Thr Glu Leu Leu Asp Gly Lys Thr Lys Leu Ile Leu
              10                  15                  20

 tct cca tat gaa cat aaa tca aaa att tct gtg aag atg gga aat aag      209
 Ser Pro Tyr Glu His Lys Ser Lys Ile Ser Val Lys Met Gly Asn Lys
          25                  30                  35

 gcc aag att gca aaa tgt cct tta aga aca aaa act ggg cac att cta      257
 Ala Lys Ile Ala Lys Cys Pro Leu Arg Thr Lys Thr Gly His Ile Leu
      40                  45                  50

 aaa tca aca caa gat act tgt att ggg agt gaa aaa ctt ttg caa aag      305
 Lys Ser Thr Gln Asp Thr Cys Ile Gly Ser Glu Lys Leu Leu Gln Lys
  55                  60                  65                  70

 aag cca gtt ggt tca gaa aca tca cag gca aaa ggt gaa aaa aat gga      353
 Lys Pro Val Gly Ser Glu Thr Ser Gln Ala Lys Gly Glu Lys Asn Gly
                  75                  80                  85

 atg act ttt tca tcc act aag gat tta tgt aaa caa tgt ata gat aaa      401
 Met Thr Phe Ser Ser Thr Lys Asp Leu Cys Lys Gln Cys Ile Asp Lys
              90                  95                 100

 gac tgt ctt cat atc cag aaa gag att tca cct gca act cct aat atg      449
 Asp Cys Leu His Ile Gln Lys Glu Ile Ser Pro Ala Thr Pro Asn Met
         105                 110                 115

 cag aag act aga aac acc gta aat aca tct cta gta ggt aaa cag aag      497
 Gln Lys Thr Arg Asn Thr Val Asn Thr Ser Leu Val Gly Lys Gln Lys
     120                 125                 130

 cct cac aaa aaa cac atc aca gct gaa aac atg aag agc agt ttg gtg      545
 Pro His Lys Lys His Ile Thr Ala Glu Asn Met Lys Ser Ser Leu Val
 135                 140                 145                 150

 tgt cta aca caa gac caa cta caa cag att ttg atg act gta aac caa      593
 Cys Leu Thr Gln Asp Gln Leu Gln Gln Ile Leu Met Thr Val Asn Gln
                 155                 160                 165

 gga aat aga tct ctt tcc ctg act gag aat gga aag gag gca aaa agt      641
 Gly Asn Arg Ser Leu Ser Leu Thr Glu Asn Gly Lys Glu Ala Lys Ser
             170                 175                 180

 caa tat agt cta tat tta aac agt att tct aat cag cca aag gat gag      689
 Gln Tyr Ser Leu Tyr Leu Asn Ser Ile Ser Asn Gln Pro Lys Asp Glu
         185                 190                 195

 aac att atg gga tta ttc aaa aaa act gaa atg gtt tca tct gtc cca      737
 Asn Ile Met Gly Leu Phe Lys Lys Thr Glu Met Val Ser Ser Val Pro
     200                 205                 210

 gct gaa aat aaa tct gtc taa at gaacatcagg agacatctaa acagtgtgag      790
 Ala Glu Asn Lys Ser Val 
 215                 220

 caaacatgct agaatgaaga cagtgaattc agcaccgggg gaggaggata agtggagaga    850

 gaacctgggg aagaatgcag tgaaaggacg atcagaaagg gaaagaacaa cagagcaagg    910

 gagacaaagg cagagcgaaa gcaatcagaa agaggaaaga gagatataga gagaacaggg    970

 aaagagatat agaacagggt ataagacatc                                    1000




      <210> 133
      <211> 705
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(705)

      <400> 133
  atg gcg gag ggc ggc agc cca gac ggg cgg gca ggg ccg ggc tcc gca      48
  Met Ala Glu Gly Gly Ser Pro Asp Gly Arg Ala Gly Pro Gly Ser Ala
    1               5                  10                  15

 ggt cgt aat ctg aag gag tgg ctg agg gag caa ttt tgt gat cat ccg       96
 Gly Arg Asn Leu Lys Glu Trp Leu Arg Glu Gln Phe Cys Asp His Pro
              20                  25                  30

 ctg gag cac tgt gag gac acg agg ctc cat gat gca gct tac gtc ggg      144
 Leu Glu His Cys Glu Asp Thr Arg Leu His Asp Ala Ala Tyr Val Gly
          35                  40                  45

 gac ctc cag acc ctc agg agc cta ttg caa gag gag agc tac cgg agg      192
 Asp Leu Gln Thr Leu Arg Ser Leu Leu Gln Glu Glu Ser Tyr Arg Arg
      50                  55                  60

 tac ggg gct gat gtt gac gtc aac cac cac ctg act cct gat gtc cag      240
 Tyr Gly Ala Asp Val Asp Val Asn His His Leu Thr Pro Asp Val Gln
  65                  70                  75                  80

 cct cga ttc tcc cgg cgg ctc acc tcc ttg gtg gtc tgc ccc ttg tac      288
 Pro Arg Phe Ser Arg Arg Leu Thr Ser Leu Val Val Cys Pro Leu Tyr
                  85                  90                  95

 atc agc gca gcc tac cac aac ctc cag tgc ttc cgg ctg ctc ctc ctg      336
 Ile Ser Ala Ala Tyr His Asn Leu Gln Cys Phe Arg Leu Leu Leu Leu
             100                 105                 110

 gct ggc gcg aac cct gac ttc aac tgc aat ggt cct gtc aac aca cag      384
 Ala Gly Ala Asn Pro Asp Phe Asn Cys Asn Gly Pro Val Asn Thr Gln
         115                 120                 125

 gga ttc tac agg ggc tcc cct ggg tgc gtc atg gat gct gtt ctg cgc      432
 Gly Phe Tyr Arg Gly Ser Pro Gly Cys Val Met Asp Ala Val Leu Arg
     130                 135                 140

 cac ggc tgt gag gca gcc ttc gtg agc ctg ctg gta gaa ttt gga gcc      480
 His Gly Cys Glu Ala Ala Phe Val Ser Leu Leu Val Glu Phe Gly Ala
 145                 150                 155                 160

 aac ctg aat cta gtg aag tgg gaa tcg ctg ggc cca gag tcg aga gga      528
 Asn Leu Asn Leu Val Lys Trp Glu Ser Leu Gly Pro Glu Ser Arg Gly
                 165                 170                 175

 aga aga aaa gtg gac cct gag gcc ttg cag gtc ttt aaa gag gcc aga      576
 Arg Arg Lys Val Asp Pro Glu Ala Leu Gln Val Phe Lys Glu Ala Arg
             180                 185                 190

 agt gtt ccc aga acc ttg ctg tgt ctg tgc cgt gtg gct gtg aga aga      624
 Ser Val Pro Arg Thr Leu Leu Cys Leu Cys Arg Val Ala Val Arg Arg
         195                 200                 205

 gct ctt ggc aaa cac cgg ctt cat ctg att cct tcg ctg cct ctg cca      672
 Ala Leu Gly Lys His Arg Leu His Leu Ile Pro Ser Leu Pro Leu Pro
     210                 215                 220

 gac ccc ata aag aag ttt cta ctc cat gag tag                          705
 Asp Pro Ile Lys Lys Phe Leu Leu His Glu 
 225                 230





      <210> 134
      <211> 348
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (39)..(308)

      <400> 134
 attcctctct tcacaccagg accagtcact gttgcagc    atg agt tcc cag cag      53
                                              Met Ser Ser Gln Gln
                                                1               5

 cag aag cag cct tgc acc cca ccc cct cag ctt cag cag cag cag gtg      101
 Gln Lys Gln Pro Cys Thr Pro Pro Pro Gln Leu Gln Gln Gln Gln Val
                  10                  15                  20

 aaa cag cct tgc cag cct cca cct cag gaa cca tgc atc ccc aaa acc      149
 Lys Gln Pro Cys Gln Pro Pro Pro Gln Glu Pro Cys Ile Pro Lys Thr
              25                  30                  35

 aag gag ccc tgc cac ccc aag gtg cct gag ccc tgc cac ccc aaa gtg      197
 Lys Glu Pro Cys His Pro Lys Val Pro Glu Pro Cys His Pro Lys Val
          40                  45                  50

 cct gag ccc tgc cag gcc aag gtt cca gag cca tgc ctc ccc aag gtg      245
 Pro Glu Pro Cys Gln Ala Lys Val Pro Glu Pro Cys Leu Pro Lys Val
      55                  60                  65

 cct gag ccc tgc cct tca ata gtc tct cca gcg tca gtc cag cag acg      293
 Pro Glu Pro Cys Pro Ser Ile Val Ser Pro Ala Ser Val Gln Gln Thr
  70                  75                  80                  85

 ccc aag cag aag taa tgtggtccac agccatgccc ttgaggagcc ggcccgcaga      348
 Pro Lys Gln Lys 






      <210> 135
      <211> 2613
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2613)

      <400> 135
  atg cac ctg gcg cgc tgc cgc tgg gcc agt gcg ccc ccg ctc tac acg      48
  Met His Leu Ala Arg Cys Arg Trp Ala Ser Ala Pro Pro Leu Tyr Thr
    1               5                  10                  15

 ctc atc gac gtg ctc aag tac agc tac gtg cgg ctt gtg tgc aag gac       96
 Leu Ile Asp Val Leu Lys Tyr Ser Tyr Val Arg Leu Val Cys Lys Asp
              20                  25                  30

 gtg cgt gcg ccc agc cgg ccc gcc gtg ggg cct ccc cag ccc ggc tgc      144
 Val Arg Ala Pro Ser Arg Pro Ala Val Gly Pro Pro Gln Pro Gly Cys
          35                  40                  45

 ccc gcc ttc atc atc gtc aag ctg agc ccg ctg cgg gac cgc ctc gtg      192
 Pro Ala Phe Ile Ile Val Lys Leu Ser Pro Leu Arg Asp Arg Leu Val
      50                  55                  60

 gtg acg gag tgc cag ctg acc cac tca cac ccg gcc tgc ccg ctg gag      240
 Val Thr Glu Cys Gln Leu Thr His Ser His Pro Ala Cys Pro Leu Glu
  65                  70                  75                  80

 ttc gcc tac tac ttc cgc ccg ggc cac ctg ctg gcc aac gcc tgc ctg      288
 Phe Ala Tyr Tyr Phe Arg Pro Gly His Leu Leu Ala Asn Ala Cys Leu
                  85                  90                  95

 ccg gtg cgc acc acc aac aag atc tcc aag cag ttc gtg gcc cca gcc      336
 Pro Val Arg Thr Thr Asn Lys Ile Ser Lys Gln Phe Val Ala Pro Ala
             100                 105                 110

 gac gtg cgc cgc ctg ctg tcc tac tgc aag ggc cgc gac cac ggc gtc      384
 Asp Val Arg Arg Leu Leu Ser Tyr Cys Lys Gly Arg Asp His Gly Val
         115                 120                 125

 ctg gac gcc ctg cac gtg ctc gag ggc ctc ttc cgc acc gac ccc gag      432
 Leu Asp Ala Leu His Val Leu Glu Gly Leu Phe Arg Thr Asp Pro Glu
     130                 135                 140

 gcc aag gtg aag ctg gtg ttc gtg gag gac cag gct gtg gtg gag acg      480
 Ala Lys Val Lys Leu Val Phe Val Glu Asp Gln Ala Val Val Glu Thr
 145                 150                 155                 160

 gtg ttc ttc ctg acg tcg cgc acc agg gcg ctg ctg cgg cgc ttc cct      528
 Val Phe Phe Leu Thr Ser Arg Thr Arg Ala Leu Leu Arg Arg Phe Pro
                 165                 170                 175

 cgc atg ctg ctg gtg gac cgg ctg ccg ggg ctg cag ggc gcg ctg gat      576
 Arg Met Leu Leu Val Asp Arg Leu Pro Gly Leu Gln Gly Ala Leu Asp
             180                 185                 190

 ctg ctg gcc gtg ctg tgc gtg gac ggc tcg ggc cgt gcg cgc cag gct      624
 Leu Leu Ala Val Leu Cys Val Asp Gly Ser Gly Arg Ala Arg Gln Ala
         195                 200                 205

 gcc tgc tgc gtg gcg cgc ccg ggc aca ccg agc ctg ctg cgc ttc gcg      672
 Ala Cys Cys Val Ala Arg Pro Gly Thr Pro Ser Leu Leu Arg Phe Ala
     210                 215                 220

 ctc gcg tcg ctg ctg cag agc gcg cca gac gtc aag ggc cgc gtg cgc      720
 Leu Ala Ser Leu Leu Gln Ser Ala Pro Asp Val Lys Gly Arg Val Arg
 225                 230                 235                 240

 tgc ctc acc gcc ggg ccc gag gtg gcg gcg cag ttg cct gca gtg cgc      768
 Cys Leu Thr Ala Gly Pro Glu Val Ala Ala Gln Leu Pro Ala Val Arg
                 245                 250                 255

 cag ctg ctg ccc tgc gcg cgc gtg cag atc tgc cgc gcg cag ggc ctg      816
 Gln Leu Leu Pro Cys Ala Arg Val Gln Ile Cys Arg Ala Gln Gly Leu
             260                 265                 270

 gag acg ctc ttc agc aag gcg cag gag ctg ggc ggc gcc ggc cgc gag      864
 Glu Thr Leu Phe Ser Lys Ala Gln Glu Leu Gly Gly Ala Gly Arg Glu
         275                 280                 285

 gac ccg ggc ctg tgg tcg cgc ctg tgc cgc ctg gct ggc gcg tcg tcg      912
 Asp Pro Gly Leu Trp Ser Arg Leu Cys Arg Leu Ala Gly Ala Ser Ser
     290                 295                 300

 ccc gca gcc tac gac gag gcg ctg gcc gag ctc cac gcc cac ggc cca      960
 Pro Ala Ala Tyr Asp Glu Ala Leu Ala Glu Leu His Ala His Gly Pro
 305                 310                 315                 320

 gcc gcc ttc gtg gac tac ttc gag cgc aac tgg gag ccc cgc cgc gac     1008
 Ala Ala Phe Val Asp Tyr Phe Glu Arg Asn Trp Glu Pro Arg Arg Asp
                 325                 330                 335

 atg tgg gtc cgc ttc cgc gcc ttc gag gcg gcc aga gac ctg gac gcg     1056
 Met Trp Val Arg Phe Arg Ala Phe Glu Ala Ala Arg Asp Leu Asp Ala
             340                 345                 350

 tgt gcc ctg gtg cga ggc cac cgc cgg cga ctg ctg cgt cgt ctc agc     1104
 Cys Ala Leu Val Arg Gly His Arg Arg Arg Leu Leu Arg Arg Leu Ser
         355                 360                 365

 ccc tcg cgt ggc gtg gcg cag tgc ctt cgc gac ctg gtg gcc atg cag     1152
 Pro Ser Arg Gly Val Ala Gln Cys Leu Arg Asp Leu Val Ala Met Gln
     370                 375                 380

 tgg gcc gac gcg gcc ggg gag gcg gtg ccc gag ggg ccc gat ggc ggg     1200
 Trp Ala Asp Ala Ala Gly Glu Ala Val Pro Glu Gly Pro Asp Gly Gly
 385                 390                 395                 400

 ggg cct tgg ctg gag gat gag cca ggg agg gga gcc cag ggg gag aac     1248
 Gly Pro Trp Leu Glu Asp Glu Pro Gly Arg Gly Ala Gln Gly Glu Asn
                 405                 410                 415

 gag agg gtg agg ggc ctg gag aca ggc gac tgg gga ggg gct ccg aaa     1296
 Glu Arg Val Arg Gly Leu Glu Thr Gly Asp Trp Gly Gly Ala Pro Lys
             420                 425                 430

 gaa gga agt att tgg agg gga gcc cag atg gag aag gag tgg gca agg     1344
 Glu Gly Ser Ile Trp Arg Gly Ala Gln Met Glu Lys Glu Trp Ala Arg
         435                 440                 445

 gca ctg gaa acc aga gac tgg ggc ggg gct cag ttc gaa ggt gag aag     1392
 Ala Leu Glu Thr Arg Asp Trp Gly Gly Ala Gln Phe Glu Gly Glu Lys
     450                 455                 460

 ggg agg gca ctg cag atc aga gat tgg aga ggg ggt cgg ttg gag aat     1440
 Gly Arg Ala Leu Gln Ile Arg Asp Trp Arg Gly Gly Arg Leu Glu Asn
 465                 470                 475                 480

 cag aag ccg agg gga ctg gaa ggg ggt gtc ttg aga ggg tcg aag tta     1488
 Gln Lys Pro Arg Gly Leu Glu Gly Gly Val Leu Arg Gly Ser Lys Leu
                 485                 490                 495

 gag aaa ggg cac ctg aga ggg cca gag att aga gac tgg agg ggg ccc     1536
 Glu Lys Gly His Leu Arg Gly Pro Glu Ile Arg Asp Trp Arg Gly Pro
             500                 505                 510

 cag ttg gag ggt gag aaa gat tgg gga ctg gaa ggt tat gtc tgg agg     1584
 Gln Leu Glu Gly Glu Lys Asp Trp Gly Leu Glu Gly Tyr Val Trp Arg
         515                 520                 525

 ggg tcc cag ttg gag gac cag gcg cta aga gga ttg gaa ggg tat acc     1632
 Gly Ser Gln Leu Glu Asp Gln Ala Leu Arg Gly Leu Glu Gly Tyr Thr
     530                 535                 540

 tgg agg gtg gcc cag ctg gaa gat cgc agg agt acc acc gac ctg agg     1680
 Trp Arg Val Ala Gln Leu Glu Asp Arg Arg Ser Thr Thr Asp Leu Arg
 545                 550                 555                 560

 ggg acc cag ttt gac tat gag agg gtc agg agt ctt gaa gga agc ccc     1728
 Gly Thr Gln Phe Asp Tyr Glu Arg Val Arg Ser Leu Glu Gly Ser Pro
                 565                 570                 575

 tgg agg ggg gcg cag ctg cac gat gaa agg gca ggg gga ctg aga act     1776
 Trp Arg Gly Ala Gln Leu His Asp Glu Arg Ala Gly Gly Leu Arg Thr
             580                 585                 590

 gca gaa tgg aag ggg cca cag tca gaa gta gag aag ggg agg ggg ctg     1824
 Ala Glu Trp Lys Gly Pro Gln Ser Glu Val Glu Lys Gly Arg Gly Leu
         595                 600                 605

 gag gtc aga aac ttg agg ggg atc ccc ttg gag aag tcc ctg gag ttg     1872
 Glu Val Arg Asn Leu Arg Gly Ile Pro Leu Glu Lys Ser Leu Glu Leu
     610                 615                 620

 gcc cct gag aac gga gac caa agg gga ccc cag tgg gaa gat gag agg     1920
 Ala Pro Glu Asn Gly Asp Gln Arg Gly Pro Gln Trp Glu Asp Glu Arg
 625                 630                 635                 640

 agg aga ggg cca gag att gca gag gag agg gga gcg agg gtg ggg gtc     1968
 Arg Arg Gly Pro Glu Ile Ala Glu Glu Arg Gly Ala Arg Val Gly Val
                 645                 650                 655

 aaa aga aga agg ggc ctg gag gat ata gtt ctg gtc cag ctg gga gac     2016
 Lys Arg Arg Arg Gly Leu Glu Asp Ile Val Leu Val Gln Leu Gly Asp
             660                 665                 670

 acg agg gtc aca ggc atg gag aat gga gat gga ggg gga gcc cgg tcc     2064
 Thr Arg Val Thr Gly Met Glu Asn Gly Asp Gly Gly Gly Ala Arg Ser
         675                 680                 685

 gtg ggc ccc aag agc cga gcc gga cga ggg atg gag tgg gga gac gca     2112
 Val Gly Pro Lys Ser Arg Ala Gly Arg Gly Met Glu Trp Gly Asp Ala
     690                 695                 700

 gga ggg cgg tgt cta ggg ctg ggg aat gga gtc gtg tct ggc acc ccg     2160
 Gly Gly Arg Cys Leu Gly Leu Gly Asn Gly Val Val Ser Gly Thr Pro
 705                 710                 715                 720

 gtg ggg act gta ttg gaa ggc agc cca gaa tgg gca gcg gcg agg agt     2208
 Val Gly Thr Val Leu Glu Gly Ser Pro Glu Trp Ala Ala Ala Arg Ser
                 725                 730                 735

 gaa cac ctg gct gca ggt gac ggc ctg cag gaa gga ggc gaa gat ggc     2256
 Glu His Leu Ala Ala Gly Asp Gly Leu Gln Glu Gly Gly Glu Asp Gly
             740                 745                 750

 ccc agg gaa cca aag agg ctt tgc cga ccc ccg gga gag gag gag gtg     2304
 Pro Arg Glu Pro Lys Arg Leu Cys Arg Pro Pro Gly Glu Glu Glu Val
         755                 760                 765

 gac tgg gaa ccc ctg gcc aaa ttc cga gca gcc tgc ggg cca gag ctg     2352
 Asp Trp Glu Pro Leu Ala Lys Phe Arg Ala Ala Cys Gly Pro Glu Leu
     770                 775                 780

 gca gac ctg gtg gct gag gag ttg gcc ttt gct agg cag cat ggg acc     2400
 Ala Asp Leu Val Ala Glu Glu Leu Ala Phe Ala Arg Gln His Gly Thr
 785                 790                 795                 800

 cgg ggt ttc cac tgg acc gga gct ggc ttt gcc ctt aag gac ggc acc     2448
 Arg Gly Phe His Trp Thr Gly Ala Gly Phe Ala Leu Lys Asp Gly Thr
                 805                 810                 815

 tcg gac ttc ttc ctg gat ggg gcc ctg aca cgc tgc agc tgc tca att     2496
 Ser Asp Phe Phe Leu Asp Gly Ala Leu Thr Arg Cys Ser Cys Ser Ile
             820                 825                 830

 cac gcc gcc cgc cgt ctg ccc tgc aga cac ctc ttt gca gcg cgc ctc     2544
 His Ala Ala Arg Arg Leu Pro Cys Arg His Leu Phe Ala Ala Arg Leu
         835                 840                 845

 ctc act ggg gct gcc tta ttc cac atg gac ctg ctc agg gat tgc tgg     2592
 Leu Thr Gly Ala Ala Leu Phe His Met Asp Leu Leu Arg Asp Cys Trp
     850                 855                 860

 ggg aga gcc cca gag ccc tga                                         2613
 Gly Arg Ala Pro Glu Pro 
 865                 870





      <210> 136
      <211> 594
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(594)

      <400> 136
  atg agt gag act caa aat tca aca agc cag aaa gca atg gat gag gat      48
  Met Ser Glu Thr Gln Asn Ser Thr Ser Gln Lys Ala Met Asp Glu Asp
    1               5                  10                  15

 aac aaa gcc gca agc caa aca atg ccg aat aca caa gac aag aac tac       96
 Asn Lys Ala Ala Ser Gln Thr Met Pro Asn Thr Gln Asp Lys Asn Tyr
              20                  25                  30

 gag gat gaa ttg act caa gta gct cta gct ctg gtt gag gat gtc atc      144
 Glu Asp Glu Leu Thr Gln Val Ala Leu Ala Leu Val Glu Asp Val Ile
          35                  40                  45

 aat tat gct gtt aag att gtg gaa gag gag cga aac cct ttg aaa aac      192
 Asn Tyr Ala Val Lys Ile Val Glu Glu Glu Arg Asn Pro Leu Lys Asn
      50                  55                  60

 atc aag tgg atg act cac ggt gaa ttc act gtg gaa aag ggt ctt aaa      240
 Ile Lys Trp Met Thr His Gly Glu Phe Thr Val Glu Lys Gly Leu Lys
  65                  70                  75                  80

 caa att gac gaa tat ttt tcg aag tgt gtt tct aaa aaa tgc tgg gca      288
 Gln Ile Asp Glu Tyr Phe Ser Lys Cys Val Ser Lys Lys Cys Trp Ala
                  85                  90                  95

 cat ggc gta gag ttt gta gag agg aaa gac tta att cac agc ttc ctc      336
 His Gly Val Glu Phe Val Glu Arg Lys Asp Leu Ile His Ser Phe Leu
             100                 105                 110

 tac atc tac tat gta cac tgg agt atc tca act gct gac cta ccc gta      384
 Tyr Ile Tyr Tyr Val His Trp Ser Ile Ser Thr Ala Asp Leu Pro Val
         115                 120                 125

 gca cga atc tct gct ggt acc tac ttc acc atg aag gtc tcc aaa acc      432
 Ala Arg Ile Ser Ala Gly Thr Tyr Phe Thr Met Lys Val Ser Lys Thr
     130                 135                 140

 aaa cca ccg gat gca ccc att gtt gtt tct tat gta ggt gac cac caa      480
 Lys Pro Pro Asp Ala Pro Ile Val Val Ser Tyr Val Gly Asp His Gln
 145                 150                 155                 160

 gca tta gtt cac aga cca gga atg gtt cgc ttt cga gaa aac tgg cag      528
 Ala Leu Val His Arg Pro Gly Met Val Arg Phe Arg Glu Asn Trp Gln
                 165                 170                 175

 aag aat ctt act gat gcc aaa tat agt ttc atg gag tca ttc ccc ttc      576
 Lys Asn Leu Thr Asp Ala Lys Tyr Ser Phe Met Glu Ser Phe Pro Phe
             180                 185                 190

 tta ttc aat cgt gtc tga                                              594
 Leu Phe Asn Arg Val 
         195





      <210> 137
      <211> 444
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(444)

      <400> 137
  atg gcc cca cca ctc cag ggg cca ggg ggt gct gct gga ggg agg aca      48
  Met Ala Pro Pro Leu Gln Gly Pro Gly Gly Ala Ala Gly Gly Arg Thr
    1               5                  10                  15

 gac gga cag gcg gcc tgg gtg gcc ggc ccc aga aag gct ggc gtg gat       96
 Asp Gly Gln Ala Ala Trp Val Ala Gly Pro Arg Lys Ala Gly Val Asp
              20                  25                  30

 gtt cga gat gag cca cca gcg aag cca gta ggg atg tct ggg ccg tcc      144
 Val Arg Asp Glu Pro Pro Ala Lys Pro Val Gly Met Ser Gly Pro Ser
          35                  40                  45

 tgg tgg gat tgt ctg gga cat cgc cac caa cac ggt gtc aga gcc atc      192
 Trp Trp Asp Cys Leu Gly His Arg His Gln His Gly Val Arg Ala Ile
      50                  55                  60

 agt ggg gac atc gga ggg gcc acc acc agg tgg ggt ata ttc aac agg      240
 Ser Gly Asp Ile Gly Gly Ala Thr Thr Arg Trp Gly Ile Phe Asn Arg
  65                  70                  75                  80

 cta gaa ccc ctg agg ctt gag agg cca acc ccc ggc agg aga cct ccc      288
 Leu Glu Pro Leu Arg Leu Glu Arg Pro Thr Pro Gly Arg Arg Pro Pro
                  85                  90                  95

 ctg acc cct ctg ctg cct ctc ctg tgg gac cct cca gta gac aca cca      336
 Leu Thr Pro Leu Leu Pro Leu Leu Trp Asp Pro Pro Val Asp Thr Pro
             100                 105                 110

 gat gag gac acc cag gag gcc tcc tcc cag gac agg agg cag ctg gct      384
 Asp Glu Asp Thr Gln Glu Ala Ser Ser Gln Asp Arg Arg Gln Leu Ala
         115                 120                 125

 ggg cag cca cgc agt gca ggg ttc agg gcc ctc cag cag gag ctc cat      432
 Gly Gln Pro Arg Ser Ala Gly Phe Arg Ala Leu Gln Gln Glu Leu His
     130                 135                 140

 gga gat ggc taa                                                      444
 Gly Asp Gly 
 145





      <210> 138
      <211> 949
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (199)..(693)

      <400> 138
 ctgacccccc tgtggtctcg aactcggtta gtccggtgaa gggacagaga agcctgggtt     60

 cccggcggca tcactgagat gctcagtcct gaattctgcc ctccattagg attatctgct    120

 ttgtgggata atttcctcat tggttgagtc agtgagttgc gtgtctcaag agagcatcct    180

 atctggtcgg agcagagc  atg gac atg gga acg agt gct ctc agc aag aag     231
                      Met Asp Met Gly Thr Ser Ala Leu Ser Lys Lys
                        1               5                  10

 ccg tgg tgg acc ctg cct caa aac ttt cat gca cca atg gtg ttt cac      279
 Pro Trp Trp Thr Leu Pro Gln Asn Phe His Ala Pro Met Val Phe His
              15                  20                  25

 atg gaa gag gac cag gag gag ctc atc ttc ggg cat ggt gac aca tac      327
 Met Glu Glu Asp Gln Glu Glu Leu Ile Phe Gly His Gly Asp Thr Tyr
          30                  35                  40

 ctt cgc tgc att gag gtg cac agc cac acc ctt att cag ctg gag agt      375
 Leu Arg Cys Ile Glu Val His Ser His Thr Leu Ile Gln Leu Glu Ser
      45                  50                  55

 tgg ttc aca gct aca ggc cag act cgt gtg act gta gtc gga cca cac      423
 Trp Phe Thr Ala Thr Gly Gln Thr Arg Val Thr Val Val Gly Pro His
  60                  65                  70                  75

 agg gca agg cag tgg ctg ctg cac atg ttt tgt tgt gtg ggg agc cag      471
 Arg Ala Arg Gln Trp Leu Leu His Met Phe Cys Cys Val Gly Ser Gln
                  80                  85                  90

 gac tcc tat cat cat gct cga ggc ctg gag atg ctg gaa cgt gtc cga      519
 Asp Ser Tyr His His Ala Arg Gly Leu Glu Met Leu Glu Arg Val Arg
              95                 100                 105

 agc cag cct ctg acc aac gat gac ctg gtc acc tcc att agt gtg cca      567
 Ser Gln Pro Leu Thr Asn Asp Asp Leu Val Thr Ser Ile Ser Val Pro
         110                 115                 120

 cca tac act gga gac ctg tct ttg gct ccc agg ata agt gga acc gtg      615
 Pro Tyr Thr Gly Asp Leu Ser Leu Ala Pro Arg Ile Ser Gly Thr Val
     125                 130                 135

 tgt ctt agc gtt cct cag cct tcc cct tac caa gtg att ggt tgt tcg      663
 Cys Leu Ser Val Pro Gln Pro Ser Pro Tyr Gln Val Ile Gly Cys Ser
 140                 145                 150                 155

 ggt ttc cat ttg agt tca ctg tat ccg taa t taaggactga tctcccctgg      714
 Gly Phe His Leu Ser Ser Leu Tyr Pro 
                 160

 gaagtgggga tgagaggaga aatcttggct tcacttttgg tgagaaagac atgatagaca    774

 ctgaggaaag tttgaacttg tggccgggac ctgtccctct caggtcttct agacatgtct    834

 gagggaagtc tcttgaatgt aagaaagtgt tattggcaaa gcaatccaat aaaataagct    894

 acctatgatg caaaaaaaaa aaaaaaaaaa atgcggccgc aagggaattc actgc         949




      <210> 139
      <211> 2439
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2061)

      <400> 139
  atg gcc gag gcc gcg gag ccg gag ggg gtt gcc ccg ggt ccc cag ggg      48
  Met Ala Glu Ala Ala Glu Pro Glu Gly Val Ala Pro Gly Pro Gln Gly
    1               5                  10                  15

 ccg ccg gag gtc ccc gcg cct ctg gct gag aga ccc gga gag cca gga       96
 Pro Pro Glu Val Pro Ala Pro Leu Ala Glu Arg Pro Gly Glu Pro Gly
              20                  25                  30

 gcc gcg ggc ggg gag gca gaa ggg ccg gag ggg agc gag ggc gca gag      144
 Ala Ala Gly Gly Glu Ala Glu Gly Pro Glu Gly Ser Glu Gly Ala Glu
          35                  40                  45

 gag gcg ccg agg ggc gcc gcc gct gtg aag gag gca gga ggc ggc ggg      192
 Glu Ala Pro Arg Gly Ala Ala Ala Val Lys Glu Ala Gly Gly Gly Gly
      50                  55                  60

 cca gac agg ggc ccg gag gcc gag gcg cgg ggc acg agg ggg gcg cac      240
 Pro Asp Arg Gly Pro Glu Ala Glu Ala Arg Gly Thr Arg Gly Ala His
  65                  70                  75                  80

 ggc gag act gag gcc gag gag gga gcc ccg gag ggt gcc gag gtg ccc      288
 Gly Glu Thr Glu Ala Glu Glu Gly Ala Pro Glu Gly Ala Glu Val Pro
                  85                  90                  95

 caa gga ggg gag gag aca agc ggc gcg cag cag gtg gag ggg gcg agc      336
 Gln Gly Gly Glu Glu Thr Ser Gly Ala Gln Gln Val Glu Gly Ala Ser
             100                 105                 110

 ccg gga cgc ggc gcg cag ggc gag ccc cgc ggg gag gct cag agg gag      384
 Pro Gly Arg Gly Ala Gln Gly Glu Pro Arg Gly Glu Ala Gln Arg Glu
         115                 120                 125

 ccc gag gac tct gcg gcc ccc gag agg cag gag gag gcg gag cag agg      432
 Pro Glu Asp Ser Ala Ala Pro Glu Arg Gln Glu Glu Ala Glu Gln Arg
     130                 135                 140

 cct gag gtc ccg gaa ggt agc gcg tcc ggg gag gcg ggg gac agc gta      480
 Pro Glu Val Pro Glu Gly Ser Ala Ser Gly Glu Ala Gly Asp Ser Val
 145                 150                 155                 160

 gac gcg gag ggc ccg ctg ggg gac aac ata gaa gcg gag ggc ccg gcg      528
 Asp Ala Glu Gly Pro Leu Gly Asp Asn Ile Glu Ala Glu Gly Pro Ala
                 165                 170                 175

 ggc gac agc gta gag gcg gag ggc cgg gtg ggg gac agc gta gac gcg      576
 Gly Asp Ser Val Glu Ala Glu Gly Arg Val Gly Asp Ser Val Asp Ala
             180                 185                 190

 gaa ggt ccg gcg ggg gac agc gta gac gcg gag ggc ccg ctg ggg gac      624
 Glu Gly Pro Ala Gly Asp Ser Val Asp Ala Glu Gly Pro Leu Gly Asp
         195                 200                 205

 aac ata caa gcc gag ggc ccg gcg ggg gac agc gta gac gcg gag ggc      672
 Asn Ile Gln Ala Glu Gly Pro Ala Gly Asp Ser Val Asp Ala Glu Gly
     210                 215                 220

 cgg gtg ggg gac agc gta gac gcg gaa ggt ccg gcg ggg gac agc gta      720
 Arg Val Gly Asp Ser Val Asp Ala Glu Gly Pro Ala Gly Asp Ser Val
 225                 230                 235                 240

 gac gcg gag ggc cgg gtg ggg gac agc gta gag gcg ggg gac ccg gcg      768
 Asp Ala Glu Gly Arg Val Gly Asp Ser Val Glu Ala Gly Asp Pro Ala
                 245                 250                 255

 ggg gac ggc gta gaa gcg ggg gtc ccg gcg ggg gac agc gta gaa gcc      816
 Gly Asp Gly Val Glu Ala Gly Val Pro Ala Gly Asp Ser Val Glu Ala
             260                 265                 270

 gaa ggc ccg gcg ggg gac agc atg gac gcc gag ggt ccg gca gga agg      864
 Glu Gly Pro Ala Gly Asp Ser Met Asp Ala Glu Gly Pro Ala Gly Arg
         275                 280                 285

 gcg cgc cgg gtc tcg ggt gag ccg cag caa tcg ggg gac ggc agc ctc      912
 Ala Arg Arg Val Ser Gly Glu Pro Gln Gln Ser Gly Asp Gly Ser Leu
     290                 295                 300

 tcg ccc cag gcc gag gca att gag gtc gca gcc ggg gag agt gcg ggg      960
 Ser Pro Gln Ala Glu Ala Ile Glu Val Ala Ala Gly Glu Ser Ala Gly
 305                 310                 315                 320

 cgc agc ccc ggt gag ctc gcc tgg gac gca gcg gag gag gcg gag gtc     1008
 Arg Ser Pro Gly Glu Leu Ala Trp Asp Ala Ala Glu Glu Ala Glu Val
                 325                 330                 335

 ccg ggg gta aag ggg tcc gaa gaa gcg gcc ccc ggg gac gca agg gca     1056
 Pro Gly Val Lys Gly Ser Glu Glu Ala Ala Pro Gly Asp Ala Arg Ala
             340                 345                 350

 gac gct ggc gag gac agg gta ggg gat ggg cca cag cag gag ccg ggg     1104
 Asp Ala Gly Glu Asp Arg Val Gly Asp Gly Pro Gln Gln Glu Pro Gly
         355                 360                 365

 gag gac gaa gag aga cga gag cgg agc ccg gag ggg cca agg gag gag     1152
 Glu Asp Glu Glu Arg Arg Glu Arg Ser Pro Glu Gly Pro Arg Glu Glu
     370                 375                 380

 gaa gca gcg ggg ggc gaa gag gaa tcc ccc gac agc agc cca cat ggg     1200
 Glu Ala Ala Gly Gly Glu Glu Glu Ser Pro Asp Ser Ser Pro His Gly
 385                 390                 395                 400

 gag gcc tcc agg ggc gcc gcg gag cct gag gcc cag ctc agc aac cac     1248
 Glu Ala Ser Arg Gly Ala Ala Glu Pro Glu Ala Gln Leu Ser Asn His
                 405                 410                 415

 ctg gcc gag gag ggc ccc gcc gag ggt agc ggc gag gcc gcg cgc gtg     1296
 Leu Ala Glu Glu Gly Pro Ala Glu Gly Ser Gly Glu Ala Ala Arg Val
             420                 425                 430

 aac ggc cgc cgg gag gac gga gag gcg tcc gag ccc cgg gcc ctg ggg     1344
 Asn Gly Arg Arg Glu Asp Gly Glu Ala Ser Glu Pro Arg Ala Leu Gly
         435                 440                 445

 cag gag cac gac atc acc ctc ttc gtc aag gct ggt tat gat ggt gag     1392
 Gln Glu His Asp Ile Thr Leu Phe Val Lys Ala Gly Tyr Asp Gly Glu
     450                 455                 460

 agt atc gga aat tgc ccg ttt tct cag cgt ctc ttt atg att ctc tgg     1440
 Ser Ile Gly Asn Cys Pro Phe Ser Gln Arg Leu Phe Met Ile Leu Trp
 465                 470                 475                 480

 ctg aaa ggc gtt ata ttt aat gtg acc aca gtg gac ctg aaa agg aaa     1488
 Leu Lys Gly Val Ile Phe Asn Val Thr Thr Val Asp Leu Lys Arg Lys
                 485                 490                 495

 ccc gca gac ctg cag aac ctg gct ccc gga aca aac cct cct ttc atg     1536
 Pro Ala Asp Leu Gln Asn Leu Ala Pro Gly Thr Asn Pro Pro Phe Met
             500                 505                 510

 act ttt gat ggt gaa gtc aag acg gat gtg aat aag atc gag gag ttc     1584
 Thr Phe Asp Gly Glu Val Lys Thr Asp Val Asn Lys Ile Glu Glu Phe
         515                 520                 525

 tta gag gag aaa tta gct ccc ccg agg tat ccc aag ctg ggg acc caa     1632
 Leu Glu Glu Lys Leu Ala Pro Pro Arg Tyr Pro Lys Leu Gly Thr Gln
     530                 535                 540

 cat ccc gaa tct aat tcc gca gga aat gac gtg ttt gcc aaa ttc tca     1680
 His Pro Glu Ser Asn Ser Ala Gly Asn Asp Val Phe Ala Lys Phe Ser
 545                 550                 555                 560

 gcg ttt ata aaa aac acg aag aag gat gca aat gag att cat gaa aag     1728
 Ala Phe Ile Lys Asn Thr Lys Lys Asp Ala Asn Glu Ile His Glu Lys
                 565                 570                 575

 aac ctg ctg aag gcc ctg agg aag ctg gat aat tac tta aat agc cct     1776
 Asn Leu Leu Lys Ala Leu Arg Lys Leu Asp Asn Tyr Leu Asn Ser Pro
             580                 585                 590

 ctg cct gat gaa ata gat gcc tac agc acc gag gat gtc act gtt tct     1824
 Leu Pro Asp Glu Ile Asp Ala Tyr Ser Thr Glu Asp Val Thr Val Ser
         595                 600                 605

 gga agg aag ttt ctg ggt ggg gac gag ctg acg ctg gct gac tgc aac     1872
 Gly Arg Lys Phe Leu Gly Gly Asp Glu Leu Thr Leu Ala Asp Cys Asn
     610                 615                 620

 ctc tta ccc aag ctc cat att att aag att gtg gcc aag aag tac aga     1920
 Leu Leu Pro Lys Leu His Ile Ile Lys Ile Val Ala Lys Lys Tyr Arg
 625                 630                 635                 640

 gat ttt gaa ttt cct tct gaa atg act ggc atc tgg aga tac ttg aat     1968
 Asp Phe Glu Phe Pro Ser Glu Met Thr Gly Ile Trp Arg Tyr Leu Asn
                 645                 650                 655

 aat gct tat gct aga gat gag ttc aca aat acg tgt cca gct gat caa     2016
 Asn Ala Tyr Ala Arg Asp Glu Phe Thr Asn Thr Cys Pro Ala Asp Gln
             660                 665                 670

 gag att gaa cac gca tat tca gat gtt gca aaa aga atg aaa tga agc     2064
 Glu Ile Glu His Ala Tyr Ser Asp Val Ala Lys Arg Met Lys 
         675                 680                 685

 tgggctgttt tctgtcttat ttctcagttg agtgagcaag gatacgaaaa cagtgtgttt   2124

 gaaaacaaat taggtttggg ttcaattcct tcaattttta aaaaactggt ctatgagagt   2184

 tttttaaatc attgagagcc tgtttttctt ctctaaaaca ttagtttaat tttcttcaaa   2244

 atgaaaatac tgctttgtaa ttacaaaatg agacacacct atcttgatat tttaaagcaa   2304

 tatcagaggg tgtaaagaag gacattttaa caatcgcctt caattttact ccacttaatt   2364

 accgaaaact tactggagaa catgttccaa atcttcagta tcttgttctc tctctctgtc   2424

 tctctctctc tctct                                                    2439




      <210> 140
      <211> 1294
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (119)..(862)

      <220>
      <221> misc_feature
      <222> (1)...(1294)
      <223> n = a,t,c or g

      <400> 140
 gagaaaagaa atgcccgggt gtcaggggtg gcatccccac tgaaagacta cagttctcaa     60

 atacagtttt cattatctaa ctttcttctt cttgactctt ttcccttgtt gtctacag      118                                                                 
 atg gaa gct gaa ctg gag aat ttc cat aag cag aac act caa ctg gag      166
 Met Glu Ala Glu Leu Glu Asn Phe His Lys Gln Asn Thr Gln Leu Glu
   1               5                  10                  15

 ctg aac atc aca gaa ttg tgg cag aaa ctg aga gcc acc gat cag gag      214
 Leu Asn Ile Thr Glu Leu Trp Gln Lys Leu Arg Ala Thr Asp Gln Glu
              20                  25                  30

 atg cgc aga gag aga cag aag gag cga gac ttg gaa gcg ctg gtc aaa      262
 Met Arg Arg Glu Arg Gln Lys Glu Arg Asp Leu Glu Ala Leu Val Lys
          35                  40                  45

 agg ttt aaa aca gac ctc cac aac tgc gta gcc tat att cag gaa ccg      310
 Arg Phe Lys Thr Asp Leu His Asn Cys Val Ala Tyr Ile Gln Glu Pro
      50                  55                  60

 cgg ctg ctg aag gag aag gtt cga ggt ctc ttt gag aag tac gtg cag      358
 Arg Leu Leu Lys Glu Lys Val Arg Gly Leu Phe Glu Lys Tyr Val Gln
  65                  70                  75                  80

 cga gca gac atg gtg gag atc gca ggg ctg aac aca gac ctg cag cag      406
 Arg Ala Asp Met Val Glu Ile Ala Gly Leu Asn Thr Asp Leu Gln Gln
                  85                  90                  95

 gag tac acc cgg cag cgg gag cac ctg gag agg aac ctg gcc act ctc      454
 Glu Tyr Thr Arg Gln Arg Glu His Leu Glu Arg Asn Leu Ala Thr Leu
             100                 105                 110

 aag aag aag gtg gtc aag gag ggc gag ctg cac cgc aca gac tac gtc      502
 Lys Lys Lys Val Val Lys Glu Gly Glu Leu His Arg Thr Asp Tyr Val
         115                 120                 125

 cgc atc atg cag gaa aat gtc tct ctg atc aag gaa att aat gag ctc      550
 Arg Ile Met Gln Glu Asn Val Ser Leu Ile Lys Glu Ile Asn Glu Leu
     130                 135                 140

 cgc agg gag ctg aag ttc act cgg tcc caa gtc tat gac ctt gaa gca      598
 Arg Arg Glu Leu Lys Phe Thr Arg Ser Gln Val Tyr Asp Leu Glu Ala
 145                 150                 155                 160

 gct ctg aaa ctg acc aag aaa gtc cga cca caa gaa gtt tca gag aca      646
 Ala Leu Lys Leu Thr Lys Lys Val Arg Pro Gln Glu Val Ser Glu Thr
                 165                 170                 175

 gaa ccc agc agg gac atg ctc agc aca gct ccc acc gca agg ttg aat      694
 Glu Pro Ser Arg Asp Met Leu Ser Thr Ala Pro Thr Ala Arg Leu Asn
             180                 185                 190

 gag caa gaa gaa act ggg agg atc att gaa atg cag cgc cta gaa atc      742
 Glu Gln Glu Glu Thr Gly Arg Ile Ile Glu Met Gln Arg Leu Glu Ile
         195                 200                 205

 cag cgc ctc aga gac cag atc caa gag caa gag cag gtc aca ggg ttc      790
 Gln Arg Leu Arg Asp Gln Ile Gln Glu Gln Glu Gln Val Thr Gly Phe
     210                 215                 220

 cac acc ctc gct gga gtt cgg ctt cct tcc ctc tcc aac tcc gag gta      838
 His Thr Leu Ala Gly Val Arg Leu Pro Ser Leu Ser Asn Ser Glu Val
 225                 230                 235                 240

 gac tta gag gtg aag acc aac tga ccccctctgg tgagccatct ccagccacag     892
 Asp Leu Glu Val Lys Thr Asn 
                 245

 ccagaagaaa cacagcatgt ctgtccccaa gccagacttg cggttggagt ctgtatggtc    952

 cctgcagcac tgaccccagc aacctctttc tcttgccctg gggaatttgg gacacagaat   1012

 aaaggtgatc ccggcgttcc ctttaatgag ggttattctt gaacctcctc aactgctctt   1072

 gcgctcggtc gatccctcag caagtcgata atctactcat agcggaatac gttttcacga   1132

 atgagggata cccatgaaaa ctggggccaa ggcataaatg ccagaaccta aaagccggtt   1192

 ttgggatttc ctagctcccc ccctacaaga tcaaaaataa gccttagttg tncggggaac   1252

 ccgccggctt aaaatcccca caaaccctga accccttcca ct                      1294




      <210> 141
      <211> 1409
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (190)..(873)

      <400> 141
 tgatcaagct tcgacaagaa cacaggccgt ttggagatgt gggaggtggt agactccaag     60

 tccgccagca gggcgtcgag gtcgtccatg gccggaccac gggcgccggc tcagggtcgc    120

 gctagctgcc cgtcccgggg ccgctcgtct atgccccgca acttttccgc cgcgagcgca    180

 ggcccggcc    atg acc gac ttc aaa ttg ggt atc gtg cgg ctc ggc cgg     228
              Met Thr Asp Phe Lys Leu Gly Ile Val Arg Leu Gly Arg
                1               5                  10

 gtg gcc ggg aag acc aaa tac acg ctg atc gat gag cag gac atc ccg      276
 Val Ala Gly Lys Thr Lys Tyr Thr Leu Ile Asp Glu Gln Asp Ile Pro
      15                  20                  25

 ctg gtg gag agc tac tcc ttt gag gcc cga atg gaa gtg gat gca gat      324
 Leu Val Glu Ser Tyr Ser Phe Glu Ala Arg Met Glu Val Asp Ala Asp
  30                  35                  40                  45

 gga aat ggt gct aag ata ttt gcc tat gcc ttt gac aag aac cga gga      372
 Gly Asn Gly Ala Lys Ile Phe Ala Tyr Ala Phe Asp Lys Asn Arg Gly
                  50                  55                  60

 agg ggc tct ggg aga ctc ctt cat gag ctg ctg tgg gag cgg cac cgg      420
 Arg Gly Ser Gly Arg Leu Leu His Glu Leu Leu Trp Glu Arg His Arg
              65                  70                  75

 ggg ggc gtg gcc ccg ggc ttc cag gtg gtg cac ctc aac gct gtg acc      468
 Gly Gly Val Ala Pro Gly Phe Gln Val Val His Leu Asn Ala Val Thr
          80                  85                  90

 gtg gac aat cgc ctg gac aac ctg caa ctg gtg ccg tgg ggc tgg cgg      516
 Val Asp Asn Arg Leu Asp Asn Leu Gln Leu Val Pro Trp Gly Trp Arg
      95                 100                 105

 ccc aag gct gaa gag acc tcc agc aag cag agg gag caa agc ttg tat      564
 Pro Lys Ala Glu Glu Thr Ser Ser Lys Gln Arg Glu Gln Ser Leu Tyr
 110                 115                 120                 125

 tgg ctt gca att cag cag ctg cct aca gac cct ata gaa gaa cag ttt      612
 Trp Leu Ala Ile Gln Gln Leu Pro Thr Asp Pro Ile Glu Glu Gln Phe
                 130                 135                 140

 cct gtc cta aat gtg acc cgg tat tat aat gcc aac ggg gat gta gtg      660
 Pro Val Leu Asn Val Thr Arg Tyr Tyr Asn Ala Asn Gly Asp Val Val
             145                 150                 155

 gaa gag gag gag aac tct tgc acc tac tat gag tgc cac tac cct ccc      708
 Glu Glu Glu Glu Asn Ser Cys Thr Tyr Tyr Glu Cys His Tyr Pro Pro
         160                 165                 170

 tgc aca gtg att gag aag cag ctc cgg gag ttc aac atc tgt ggg cgc      756
 Cys Thr Val Ile Glu Lys Gln Leu Arg Glu Phe Asn Ile Cys Gly Arg
     175                 180                 185

 tgc cag gtg gcc cgg tac tgc ggc tcc cag tgc cag cag aag gac tgg      804
 Cys Gln Val Ala Arg Tyr Cys Gly Ser Gln Cys Gln Gln Lys Asp Trp
 190                 195                 200                 205

 cct gcc cac aag aag cac tgt cgg gag agg aag cgt ccc ttc cag cat      852
 Pro Ala His Lys Lys His Cys Arg Glu Arg Lys Arg Pro Phe Gln His
                 210                 215                 220

 gag ctt gag cca gag cga tga cg ggcaggggag ccacacatac tcacagcccc      905
 Glu Leu Glu Pro Glu Arg 
             225

 cgggctctac cctgggcaca gcagagacag actggtggtt gaacctggag gtgccaaaaa    965

 agccagctgc gggcccagga cagctgccgt gagactcccg atgtcacagg cagtctgtgt   1025

 ggttacagcg cccctcagtg ttcatctcca gcagagacaa cggaggaggc tcccaccagg   1085

 acggttctca ttatttatat gttaatatgt ttgtaaactc atgtacagtt ttttttgggg   1145

 gggaggcaat gggaagggta gaaattacaa atagaatcat ttgctgtaat ccttaaatgg   1205

 caaacggtca ggccacgtga ctaaaaactg tcctgttgtc gaagcttctc ccctgggccg   1265

 ccgggagccc cgtggagcgc ggcctgcacg ggagttgtgt ccacaaaggc aaagtaaagg   1325

 ggtggaatca taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaattctg   1385

 cggccgcaag ggaattctag tgcc                                          1409




      <210> 142
      <211> 372
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(372)

      <400> 142
  atg gcc ccg ggg gcg gga gag cac cac ctg gct cgc cgg gtg cgc agc      48
  Met Ala Pro Gly Ala Gly Glu His His Leu Ala Arg Arg Val Arg Ser
    1               5                  10                  15

 gac ccg ggt gga gga ggc ctg gcc tac gcc gct tat gcc aac ggg ctg       96
 Asp Pro Gly Gly Gly Gly Leu Ala Tyr Ala Ala Tyr Ala Asn Gly Leu
              20                  25                  30

 ggg gca cag ctg cct ggc ttg cag ccg tcg gac acg tcg ggc tcc tcc      144
 Gly Ala Gln Leu Pro Gly Leu Gln Pro Ser Asp Thr Ser Gly Ser Ser
          35                  40                  45

 tct tcg tcc agc tcc tcc tcc agc tct tca tcc tct tcc tcc ggg ctt      192
 Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Gly Leu
      50                  55                  60

 cgg cgt aaa ggc agc cgc gac tgc tcc gtg tgc ttc gag agc gaa gtg      240
 Arg Arg Lys Gly Ser Arg Asp Cys Ser Val Cys Phe Glu Ser Glu Val
  65                  70                  75                  80

 att gcc gcg ctg gtg ccc tgt ggc cac aac ctc ttc tgc atg gag tgc      288
 Ile Ala Ala Leu Val Pro Cys Gly His Asn Leu Phe Cys Met Glu Cys
                  85                  90                  95

 gcc aat cgc atc tgt gag aag agc gag ccc gag tgc ccg gtc tgc cac      336
 Ala Asn Arg Ile Cys Glu Lys Ser Glu Pro Glu Cys Pro Val Cys His
             100                 105                 110

 acc gcg gtc act cag gcc atc cgc atc ttt tct taa                      372
 Thr Ala Val Thr Gln Ala Ile Arg Ile Phe Ser 
         115                 120





      <210> 143
      <211> 950
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (192)..(590)

      <400> 143
 actactacta aattgccggc cgcgtcgaca aaaaaagaaa aaaaagaagt acaagagtat     60

 aataccttca tgacagtaca gctgactcaa tccggaccac gtgtcaaggt gtaatctcga    120

 ccttgaaagc tcattatctg agaaggactt ttcagcacat cctagaagca gcggatggtg    180

 aggacacagc t atg atc agg gaa ttt tgg aga aac tac agc atc atg gat     230
              Met Ile Arg Glu Phe Trp Arg Asn Tyr Ser Ile Met Asp
                1               5                  10

 gct gtg gac atg gcc atc gca tgg gag gag ctc aaa cca gca cta atg      278
 Ala Val Asp Met Ala Ile Ala Trp Glu Glu Leu Lys Pro Ala Leu Met
      15                  20                  25

 aac agc atg tgg aag aag att tgg cct gag tgt gtt cag gcc cag cgt      326
 Asn Ser Met Trp Lys Lys Ile Trp Pro Glu Cys Val Gln Ala Gln Arg
  30                  35                  40                  45

 ttt tcc cag gca gat aac att gca cag ctt caa aaa aac att gtg acc      374
 Phe Ser Gln Ala Asp Asn Ile Ala Gln Leu Gln Lys Asn Ile Val Thr
                  50                  55                  60

 ctt gcc aga aat gtg gcc ttt gaa gag gtt gct gag gct gct gtg gac      422
 Leu Ala Arg Asn Val Ala Phe Glu Glu Val Ala Glu Ala Ala Val Asp
              65                  70                  75

 cag ttg ctg cag tcc cat gaa gaa gat ctc tca aat gag gaa ctg atg      470
 Gln Leu Leu Gln Ser His Glu Glu Asp Leu Ser Asn Glu Glu Leu Met
          80                  85                  90

 cgg ctg gaa cag gag ctg gca gtg ggg gag gag gag agg gaa gat ggt      518
 Arg Leu Glu Gln Glu Leu Ala Val Gly Glu Glu Glu Arg Glu Asp Gly
      95                 100                 105

 ccc tgg gca ctg tgg cag cta acc aca gga aga ctg tcg gca gcc ctc      566
 Pro Trp Ala Leu Trp Gln Leu Thr Thr Gly Arg Leu Ser Ala Ala Leu
 110                 115                 120                 125

 tca cat ttt gag gct ggc ttg tag gtccttgcta gtaacagccc taatgatgac     620
 Ser His Phe Glu Ala Gly Leu 
                 130

 tggaaactga gaggttccag agaaatcagt gttgcagtaa actgctagca ggagctgtac    680

 aatgagaaaa agcgccactc aaaacaactc tcttaggtca tttttcaatg tgtgtaacca    740

 aaagttaatc agaataaagc ggaagcacca tgatgacctc aacagtggag gcccagccag    800

 gcctccctgc tctgtggtgt tggacatccc tggaaacctt gctgttggta tttccatttt    860

 gatacttgag agcatcaaat tttgtcatta aaatgttatt taaatattgc ttttaaaagc    920

 tcatatatgt gtaagaatcg ccaggaaaac                                     950




      <210> 144
      <211> 1213
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (494)..(958)

      <400> 144
 tctggaggtg ctttctgccc ctgtctgggg aaagctgctg ggcagctcat tctgtgactg     60

 tagctccaga tgagtgctcc ctggcagcag ccctgctccc tgccttccct gcttctgatc    120

 gtcttttctt tgggttggct caggatgcag tgaggatgga gagagtggac ggatgtctca    180

 aaagtcagct ctaaagtcgg agtcagaaca ggggctgccg atgctctgtc tcccagtcta    240

 cctggagtga ttcaacatag aaatcaataa aacaaatgcc accatggctg agtgagacct    300

 ttcatttttc ttcccaggtg ttggagaagg cttctggtga aggatttggc aaaaccgccg    360

 agggtccttc ctggtgctgc tcctgaggga atgcttccga gacctgagct ggctggcact    420

 catccatagc gtccgtgggg aggcggggct gctggtgacg agtatcgtcc cgaagacccc    480

 gtttttctgg gcc   atg cac gtc act gag gct ctg cac cag aac atg cag     529
                  Met His Val Thr Glu Ala Leu His Gln Asn Met Gln
                    1               5                  10

 gct ctg ttt agc acc ctg gct cag gcg gag gag cag cag ccc tac ctg      577
 Ala Leu Phe Ser Thr Leu Ala Gln Ala Glu Glu Gln Gln Pro Tyr Leu
          15                  20                  25

 gag ggc tcc acc gtt atg cgc ggg act cgc tgt ctg gca gag tac cac      625
 Glu Gly Ser Thr Val Met Arg Gly Thr Arg Cys Leu Ala Glu Tyr His
      30                  35                  40

 ctg ggg gat tat gga cac gcc tgg aac agg tgt tgg gtg ctg gac agg      673
 Leu Gly Asp Tyr Gly His Ala Trp Asn Arg Cys Trp Val Leu Asp Arg
  45                  50                  55                  60

 gtg gac acc tgg gct gtg gtc atg ttc att gat ttt gga cag ttg gcc      721
 Val Asp Thr Trp Ala Val Val Met Phe Ile Asp Phe Gly Gln Leu Ala
                  65                  70                  75

 acc atc cct gtg cag tct ctg cgc agc cta gac agc gac gac ttc tgg      769
 Thr Ile Pro Val Gln Ser Leu Arg Ser Leu Asp Ser Asp Asp Phe Trp
              80                  85                  90

 acc atc cca ccc ctg act cag cca ttc atg ctg gag aaa gac att ttg      817
 Thr Ile Pro Pro Leu Thr Gln Pro Phe Met Leu Glu Lys Asp Ile Leu
          95                 100                 105

 agt tcg tat gag gtt gtc cat cga atc ctc aaa ggg aaa atc act ggt      865
 Ser Ser Tyr Glu Val Val His Arg Ile Leu Lys Gly Lys Ile Thr Gly
     110                 115                 120

 gct ttg aac tcg gcg gta act gct cct gca tct aac ttg gct gtt gtc      913
 Ala Leu Asn Ser Ala Val Thr Ala Pro Ala Ser Asn Leu Ala Val Val
 125                 130                 135                 140

 cct cca ctc ctg ccc ttg ggg tgt ctg cag cag gct gct gcc tag gcc      961
 Pro Pro Leu Leu Pro Leu Gly Cys Leu Gln Gln Ala Ala Ala 
                 145                 150

 tggacacagt atttacctgg cattctttta gatcaaacga actggttatc tgaggggttg   1021

 ggtgaactgg ctcgggtggg ccttccttcc caccaaggct ttgtctttct cttccagttg   1081

 cacatcctaa agtttgaaga gtctaaataa cggggcttcc ctcagcatgt tccctctcct   1141

 gtttgccacg gatccagagg ccacctgccc tgtcttctcg tacccctttc actcttgagg   1201

 cctgggaggt gg                                                       1213




      <210> 145
      <211> 2548
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (632)..(2446)

      <400> 145
 gctgcagcgt gggcctggtc ccctgccaag ccaggagcgc agcccggagc cagcgcggcc     60

 cccgggtccc tgcgcttatg gcgagggtcg cgggggaaca gcccctggta gggactcgca    120

 gctggcccgc gcgccagggt acacacgggc tgcgggagaa ggtgaaagtt aggatgcagc    180

 acgagctccg agagtggcct gggctgtgcc tcctaagaga acagccgagc gcatgcgccc    240

 tgcccgagga ctggcagaga gacggcaata tggcgagaat gcctggcagc ggggactgta    300

 acaccagcgc gggcggcagc gccagcgctg ccgccgccgc cgccgagaac aatggggagc    360

 ggggcgaggg cgagcgcggc gcggggggcc gcggccgccg ccacagccgt ccgcactact    420

 gcagcgcggg cgaggaggag gaggaagagg aggaggagga cgagatccag gaggtgcaga    480

 taacggggga cgaggaggag gaggaggacg gaggtggggg gctggaggag gacgaggagg    540

 aggaggaaga ggaggagtgg ggctggactg ggacgagccc ctggagcccg aggactcggc    600

 cggggaggag ctggagcccg agccggtcca t   atg atc aat atg gac cag agc     652
                                      Met Ile Asn Met Asp Gln Ser
                                        1               5

 gcc gcg ctg gag ccc gag gcg ccg ccg cga ctg ctg gcg ccc cgg gcc      700
 Ala Ala Leu Glu Pro Glu Ala Pro Pro Arg Leu Leu Ala Pro Arg Ala
          10                  15                  20

 cgc ggt ggg ccg ccc ggg gac ggc tcc gag ctg gac ccc gac gtg ctg      748
 Arg Gly Gly Pro Pro Gly Asp Gly Ser Glu Leu Asp Pro Asp Val Leu
      25                  30                  35

 cag cgc ccc gag cgg gcc cgg ctg agc gag aac acc cgg ctg gcc acc      796
 Gln Arg Pro Glu Arg Ala Arg Leu Ser Glu Asn Thr Arg Leu Ala Thr
  40                  45                  50                  55

 cgc tac gcc gtg cgc atc ttc cgg gag tac ctg agc gag aag gcg cag      844
 Arg Tyr Ala Val Arg Ile Phe Arg Glu Tyr Leu Ser Glu Lys Ala Gln
                  60                  65                  70

 agc ccg gac ttc gag acc atg gac aag ggg gcg ctg tgc cgc gtg ctg      892
 Ser Pro Asp Phe Glu Thr Met Asp Lys Gly Ala Leu Cys Arg Val Leu
              75                  80                  85

 cgc tcc ttc tat gcc gag gcc cgc tcc aaa agc ggc cag ctc tac agc      940
 Arg Ser Phe Tyr Ala Glu Ala Arg Ser Lys Ser Gly Gln Leu Tyr Ser
          90                  95                 100

 aag tcg tcg ctc atc agc atc cgc agc tcc ctc aac cgc tac ctc aat      988
 Lys Ser Ser Leu Ile Ser Ile Arg Ser Ser Leu Asn Arg Tyr Leu Asn
     105                 110                 115

 gag ccc ccg tac tgc cgc acg ctc gac ctc acc aag gac ccc gag ctg     1036
 Glu Pro Pro Tyr Cys Arg Thr Leu Asp Leu Thr Lys Asp Pro Glu Leu
 120                 125                 130                 135

 cgc agc gcc aac ctg acg ctg gcc gcg gtc atc cgc aag ctc gag gag     1084
 Arg Ser Ala Asn Leu Thr Leu Ala Ala Val Ile Arg Lys Leu Glu Glu
                 140                 145                 150

 cag ggc gcc ggg ccg gtg gtg cag aag caa gcc atc acg cgc gcc gac     1132
 Gln Gly Ala Gly Pro Val Val Gln Lys Gln Ala Ile Thr Arg Ala Asp
             155                 160                 165

 ctg cgc aag ctg tac acc tcc agc gtc ttc agc acc aac acg ccc ttc     1180
 Leu Arg Lys Leu Tyr Thr Ser Ser Val Phe Ser Thr Asn Thr Pro Phe
         170                 175                 180

 ggg ctg ctc aac aag gtc tgg ttc gag acg tgc atg tac ttc tgt acc     1228
 Gly Leu Leu Asn Lys Val Trp Phe Glu Thr Cys Met Tyr Phe Cys Thr
     185                 190                 195

 cgc ggc cgc gag aac cag cgt gag ttg gag gag gac tct ttt ggg ctg     1276
 Arg Gly Arg Glu Asn Gln Arg Glu Leu Glu Glu Asp Ser Phe Gly Leu
 200                 205                 210                 215

 gcc atg gac gag gac ggt cgc aag ttc gtc tac ttc aag tcc ctc ggg     1324
 Ala Met Asp Glu Asp Gly Arg Lys Phe Val Tyr Phe Lys Ser Leu Gly
                 220                 225                 230

 ccc tac cac aag tcg cgc tcg tcg tcg tgg agc aag aag cgc gcc gag     1372
 Pro Tyr His Lys Ser Arg Ser Ser Ser Trp Ser Lys Lys Arg Ala Glu
             235                 240                 245

 agc agc gac gag gag aac ttg ccc cgc atg tat gag acg ggc acc gag     1420
 Ser Ser Asp Glu Glu Asn Leu Pro Arg Met Tyr Glu Thr Gly Thr Glu
         250                 255                 260

 ttc tgc ccc tac gcc agc ttc gtc aag tac ctg tcg aaa cgc aac cct     1468
 Phe Cys Pro Tyr Ala Ser Phe Val Lys Tyr Leu Ser Lys Arg Asn Pro
     265                 270                 275

 ctc tgc aag gcg ttc ttc cag cgg ccc cgg gac cac tgc agc gag ggc     1516
 Leu Cys Lys Ala Phe Phe Gln Arg Pro Arg Asp His Cys Ser Glu Gly
 280                 285                 290                 295

 gat gtg acc tgg tac gag aac aaa gcc atc ggc aag aac ttg cta ggc     1564
 Asp Val Thr Trp Tyr Glu Asn Lys Ala Ile Gly Lys Asn Leu Leu Gly
                 300                 305                 310

 act cgg atg cag atg ctc tcc aag gcg gcc aag ctc tcc aag acc tac     1612
 Thr Arg Met Gln Met Leu Ser Lys Ala Ala Lys Leu Ser Lys Thr Tyr
             315                 320                 325

 acc aac cac tgc atc ggc gcc gtc tcc atc gcc acg ctc aac agc atc     1660
 Thr Asn His Cys Ile Gly Ala Val Ser Ile Ala Thr Leu Asn Ser Ile
         330                 335                 340

 gcg ggc att ggc acc aag ctg ggc tcg ccc gcc ccg cag ggc tgc tac     1708
 Ala Gly Ile Gly Thr Lys Leu Gly Ser Pro Ala Pro Gln Gly Cys Tyr
     345                 350                 355

 gcc gag gct ctg aac ggg gcg gca cgg cac cac tcc cac cac ccc ccc     1756
 Ala Glu Ala Leu Asn Gly Ala Ala Arg His His Ser His His Pro Pro
 360                 365                 370                 375

 acc cat ccc tcc cac cac cac cgc ccc cag ccg ccc tcg ctg ggg aac     1804
 Thr His Pro Ser His His His Arg Pro Gln Pro Pro Ser Leu Gly Asn
                 380                 385                 390

 act tac atc ctc ccc aaa gac agc cag gtc ggg ccc gac gtg aaa tcc     1852
 Thr Tyr Ile Leu Pro Lys Asp Ser Gln Val Gly Pro Asp Val Lys Ser
             395                 400                 405

 gag gct gcg ccc aag cgc gcc ctg tac gag tct gtg ttc ggg tcg ggg     1900
 Glu Ala Ala Pro Lys Arg Ala Leu Tyr Glu Ser Val Phe Gly Ser Gly
         410                 415                 420

 gaa atc tgc ggc ccc act tcc ccc aaa aga ctt tgt atc cgc ccc tcg     1948
 Glu Ile Cys Gly Pro Thr Ser Pro Lys Arg Leu Cys Ile Arg Pro Ser
     425                 430                 435

 gag cct gtg gat gcg gtg gtg gtg gtt tcc gtg aaa cac gac ccc ctg     1996
 Glu Pro Val Asp Ala Val Val Val Val Ser Val Lys His Asp Pro Leu
 440                 445                 450                 455

 cct ctt ctt cca gaa gcc aat ggg cac aga agc acc aat tct ccc aca     2044
 Pro Leu Leu Pro Glu Ala Asn Gly His Arg Ser Thr Asn Ser Pro Thr
                 460                 465                 470

 ata gtt tca cct gct att gtt tcc ccc acc cag gac agt cgg ccc aat     2092
 Ile Val Ser Pro Ala Ile Val Ser Pro Thr Gln Asp Ser Arg Pro Asn
             475                 480                 485

 atg tca aga cct ctg atc act aga tcc cct gca tct cca ctg aac aac     2140
 Met Ser Arg Pro Leu Ile Thr Arg Ser Pro Ala Ser Pro Leu Asn Asn
         490                 495                 500

 caa ggc atc cct act cca gca caa ctc aca aaa tcc aat gcg cct gtc     2188
 Gln Gly Ile Pro Thr Pro Ala Gln Leu Thr Lys Ser Asn Ala Pro Val
     505                 510                 515

 cac att gat gtg ggc ggc cac atg tac acc agc agc ctg gcc acc ctc     2236
 His Ile Asp Val Gly Gly His Met Tyr Thr Ser Ser Leu Ala Thr Leu
 520                 525                 530                 535

 acc aaa tac cct gaa tcc aga atc gga aga ctt ttt gat ggt aca gag     2284
 Thr Lys Tyr Pro Glu Ser Arg Ile Gly Arg Leu Phe Asp Gly Thr Glu
                 540                 545                 550

 ccc att gtt ttg gac agt ctc aaa cag cac tat ttc att gac aga gat     2332
 Pro Ile Val Leu Asp Ser Leu Lys Gln His Tyr Phe Ile Asp Arg Asp
             555                 560                 565

 gga cag atg ttc aga tat atc ttg aat ttt cta cga aca tcc aaa ctc     2380
 Gly Gln Met Phe Arg Tyr Ile Leu Asn Phe Leu Arg Thr Ser Lys Leu
         570                 575                 580

 ctc att cct gat gat ttc aag gac tac act ttg tta tat gaa gag gca     2428
 Leu Ile Pro Asp Asp Phe Lys Asp Tyr Thr Leu Leu Tyr Glu Glu Ala
     585                 590                 595

 aaa tat ttt cag ctt tag cccatg ttggtggaga tgggaaagat ggaagcggga     2482
 Lys Tyr Phe Gln Leu 
 600

 catagaaact ggtccaattt caaggccctg gaatgcctct tctgcttggg gccccagacc   2542

 tcggaa                                                              2548




      <210> 146
      <211> 3069
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (757)..(3069)

      <400> 146
 gtatgttggg agcagcagct gaggccagga ggcccaggcc ccccagccgc cccaccccca     60

 gcgctggatg ccctatcccc gttccttcgg aagaaggccc agattctgga ggtgctgaga    120

 gccctggaag agactgaccc cttgcttctc tgctcacctg ccaccccctg gcggcctcca    180

 ggccaggggc ctggctcccc agagcccatc aacggcgagc tgtgtggccc gcctcagcct    240

 gaaccctcac cctgggcgcc ctgcctgctg ctaggccctg gcaacctggg aggcctgctg    300

 cactgggagc gcctcttggg gggtctggga ggggaagagg acactgggcg gccctggggt    360

 cctagcaggg gacctcctca ggcccagggc accagctctg gcccaaactg tgccccaggc    420

 agcagctcct cctcctcttc tgatgaggca ggtgacccca atgaggcacc cagccccgac    480

 accctgctcg gtgccctggc ccgcagacag ttgaacctgg gccagctcct tgaggacaca    540

 gagtcttacc tacaggcctt cctggccggg gctgcaggcc cactcaatgg ggaccaccca    600

 ggtcctgggc agtcatcctc cccagaccag gcgcccccac agctgtctaa gtccaaaggc    660

 ctccccaagt cagcttgggg tgggggtacc ccagaggccc acaggccagg cttcggtgct    720

 acctcagagg gccaggggcc cctccccttc cttagc  atg ttc atg ggt gct ggg     774
                                          Met Phe Met Gly Ala Gly
                                            1               5

 gat gcc cca ctg ggc tct cgg cct ggc cac ccc cat tcc tca tct cag      822
 Asp Ala Pro Leu Gly Ser Arg Pro Gly His Pro His Ser Ser Ser Gln
              10                  15                  20

 gtg aaa agc aag ctc caa att ggc ccc cct tct cct ggg gaa gct cag      870
 Val Lys Ser Lys Leu Gln Ile Gly Pro Pro Ser Pro Gly Glu Ala Gln
          25                  30                  35

 gga ccc ctt ctg ccc tct cca gct agg ggt ctc aag ttt cta aag ctg      918
 Gly Pro Leu Leu Pro Ser Pro Ala Arg Gly Leu Lys Phe Leu Lys Leu
      40                  45                  50

 cct cca acc tcg gag aag agc ccc agc cca gga ggc ccg cag ctc agt      966
 Pro Pro Thr Ser Glu Lys Ser Pro Ser Pro Gly Gly Pro Gln Leu Ser
  55                  60                  65                  70

 ccc cag ctc ccc cgg aac tcg cga atc ccc tgt cgg aac agt ggc tca     1014
 Pro Gln Leu Pro Arg Asn Ser Arg Ile Pro Cys Arg Asn Ser Gly Ser
                  75                  80                  85

 gac ggc agc ccc tcc cca ctg ttg gcc cga agg ggt ctg ggt gga gga     1062
 Asp Gly Ser Pro Ser Pro Leu Leu Ala Arg Arg Gly Leu Gly Gly Gly
              90                  95                 100

 gag ctg tcc cca gag ggg gcg caa ggc ctg ccc acc agc cct tca ccc     1110
 Glu Leu Ser Pro Glu Gly Ala Gln Gly Leu Pro Thr Ser Pro Ser Pro
         105                 110                 115

 tgc tac aca acc cca gac tcc aca cag ctc aga ccc ccg cag tca gcc     1158
 Cys Tyr Thr Thr Pro Asp Ser Thr Gln Leu Arg Pro Pro Gln Ser Ala
     120                 125                 130

 ttg tcc acc acg ctg tcc cca ggc cca gtg gtg tct ccc tgc tat gag     1206
 Leu Ser Thr Thr Leu Ser Pro Gly Pro Val Val Ser Pro Cys Tyr Glu
 135                 140                 145                 150

 aac att ctg gac ctt tct cgg agc acc ttt agg ggg cct tcc cca gag     1254
 Asn Ile Leu Asp Leu Ser Arg Ser Thr Phe Arg Gly Pro Ser Pro Glu
                 155                 160                 165

 cca cct cca tcc cca ctg cag gtg ccc acc tac cca cag cta act ctg     1302
 Pro Pro Pro Ser Pro Leu Gln Val Pro Thr Tyr Pro Gln Leu Thr Leu
             170                 175                 180

 gag gta cca cag gcc cct gag gtc ctc aga agc cct gga gtc ccc ccc     1350
 Glu Val Pro Gln Ala Pro Glu Val Leu Arg Ser Pro Gly Val Pro Pro
         185                 190                 195

 agt cct tgc ctc cca gaa tct tac ccc tat ggg agc ccc caa gag aag     1398
 Ser Pro Cys Leu Pro Glu Ser Tyr Pro Tyr Gly Ser Pro Gln Glu Lys
     200                 205                 210

 agt ttg gac aag gca ggc tcg gag tct ccc cat ccc ggc cgc agg acc     1446
 Ser Leu Asp Lys Ala Gly Ser Glu Ser Pro His Pro Gly Arg Arg Thr
 215                 220                 225                 230

 cca ggc aac tca tcc aag aag ccc agc cag ggg tca gga cgg cga cct     1494
 Pro Gly Asn Ser Ser Lys Lys Pro Ser Gln Gly Ser Gly Arg Arg Pro
                 235                 240                 245

 ggg gat cct ggc agc aca cct ctg cgg gac aga ctg gcg gcc ctg ggg     1542
 Gly Asp Pro Gly Ser Thr Pro Leu Arg Asp Arg Leu Ala Ala Leu Gly
             250                 255                 260

 aag ctg aag aca ggc ccc gag ggg gcc ctg ggc tca gag aag aat ggg     1590
 Lys Leu Lys Thr Gly Pro Glu Gly Ala Leu Gly Ser Glu Lys Asn Gly
         265                 270                 275

 gtg cca gcc agg cct ggc atc gaa aag acc cgg gga cct ggg aag tca     1638
 Val Pro Ala Arg Pro Gly Ile Glu Lys Thr Arg Gly Pro Gly Lys Ser
     280                 285                 290

 ggg gag agt gct gga gac atg gtg ccc tcc atc cac agg cca ctg gag     1686
 Gly Glu Ser Ala Gly Asp Met Val Pro Ser Ile His Arg Pro Leu Glu
 295                 300                 305                 310

 cag cta gaa gcc aag ggg ggg ata cgg ggg gca gtg gcc ttg ggc aca     1734
 Gln Leu Glu Ala Lys Gly Gly Ile Arg Gly Ala Val Ala Leu Gly Thr
                 315                 320                 325

 aac agc ctg aag cag cag gaa cct gga ctt atg ggg gat ccc ggg gcc     1782
 Asn Ser Leu Lys Gln Gln Glu Pro Gly Leu Met Gly Asp Pro Gly Ala
             330                 335                 340

 cga gtc tac tcc tct cac tcc atg ggg gcc cgg gtg gac ctg gag cct     1830
 Arg Val Tyr Ser Ser His Ser Met Gly Ala Arg Val Asp Leu Glu Pro
         345                 350                 355

 gtc tca cca agg agc tgc ctc acc aaa gtg gag ctg gcc aag agc cgg     1878
 Val Ser Pro Arg Ser Cys Leu Thr Lys Val Glu Leu Ala Lys Ser Arg
     360                 365                 370

 ctg gca ggg gcc ctg tgc ccc cag tcc aca ccc cta gta cct ggc ccc     1926
 Leu Ala Gly Ala Leu Cys Pro Gln Ser Thr Pro Leu Val Pro Gly Pro
 375                 380                 385                 390

 act gac cca agt cag ggc cct gag ggg ctg gcc cca cac tca gcc atc     1974
 Thr Asp Pro Ser Gln Gly Pro Glu Gly Leu Ala Pro His Ser Ala Ile
                 395                 400                 405

 gag gag aag gtg atg aag ggc att gag gag aac gtg ctg cgg ctc cag     2022
 Glu Glu Lys Val Met Lys Gly Ile Glu Glu Asn Val Leu Arg Leu Gln
             410                 415                 420

 ggc cag gag cga gcc cct ggc gcc gag gtc aag cac cgc aac acc agc     2070
 Gly Gln Glu Arg Ala Pro Gly Ala Glu Val Lys His Arg Asn Thr Ser
         425                 430                 435

 agc atc gcc agc tgg ttc ggc ctt aag aag agc aag ctg cca gcg ctg     2118
 Ser Ile Ala Ser Trp Phe Gly Leu Lys Lys Ser Lys Leu Pro Ala Leu
     440                 445                 450

 aac cgc cgc aca gag gcc acc aag aac aag gag ggg gct ggc ggg ggc     2166
 Asn Arg Arg Thr Glu Ala Thr Lys Asn Lys Glu Gly Ala Gly Gly Gly
 455                 460                 465                 470

 tcc ccg ctc cgg agg gaa gtc aag atg gaa gcc cgg aag ctg gag gcc     2214
 Ser Pro Leu Arg Arg Glu Val Lys Met Glu Ala Arg Lys Leu Glu Ala
                 475                 480                 485

 gag agc ctc aac atc tcc aag ctg atg gcc aag gcg gaa gac ctg cgt     2262
 Glu Ser Leu Asn Ile Ser Lys Leu Met Ala Lys Ala Glu Asp Leu Arg
             490                 495                 500

 cgg gca ctg gaa gag gag aag gcc tac cta agc agc cgg gcc cgc caa     2310
 Arg Ala Leu Glu Glu Glu Lys Ala Tyr Leu Ser Ser Arg Ala Arg Gln
         505                 510                 515

 cgc ctg gtg ccc agc ccc agg gcc caa cac ggg gct ggg gca ggt gca     2358
 Arg Leu Val Pro Ser Pro Arg Ala Gln His Gly Ala Gly Ala Gly Ala
     520                 525                 530

 ggg cca gct ggc tgg cat gta cca agg tgc aga cac ctt cat gca gca     2406
 Gly Pro Ala Gly Trp His Val Pro Arg Cys Arg His Leu His Ala Ala
 535                 540                 545                 550

 gct gct aaa cag gaa agg gat aag ggg agt cct ctt ccc atc ttg ccc     2454
 Ala Ala Lys Gln Glu Arg Asp Lys Gly Ser Pro Leu Pro Ile Leu Pro
                 555                 560                 565

 ttt gac atc tgc cac aac agg agt tgt ggt tta aag aag gga tcc acc     2502
 Phe Asp Ile Cys His Asn Arg Ser Cys Gly Leu Lys Lys Gly Ser Thr
             570                 575                 580

 cat ctt ggg gtt gct ctg tct ggg cca gat gag gca gaa agt ctg cag     2550
 His Leu Gly Val Ala Leu Ser Gly Pro Asp Glu Ala Glu Ser Leu Gln
         585                 590                 595

 gaa ttg ggc ccc agg gtg gat ggc aag gag ctg cca tcc aag agc tgg     2598
 Glu Leu Gly Pro Arg Val Asp Gly Lys Glu Leu Pro Ser Lys Ser Trp
     600                 605                 610

 cgg gag ccc aag cct gag tac ggg gat ttc cag ccg gtg tct tct gac     2646
 Arg Glu Pro Lys Pro Glu Tyr Gly Asp Phe Gln Pro Val Ser Ser Asp
 615                 620                 625                 630

 ccc aag agc ccc tgg cca gcc tgt ggg ccc cgg aat ggc ctg gtg ggc     2694
 Pro Lys Ser Pro Trp Pro Ala Cys Gly Pro Arg Asn Gly Leu Val Gly
                 635                 640                 645

 cct ctt cag ggc tgc gga aaa cct cct gga aag cag gtg cca ggc tct     2742
 Pro Leu Gln Gly Cys Gly Lys Pro Pro Gly Lys Gln Val Pro Gly Ser
             650                 655                 660

 gtg tgc cat ctt ggt gcc aag cac cag gtg ggc act gga gct aca cag     2790
 Val Cys His Leu Gly Ala Lys His Gln Val Gly Thr Gly Ala Thr Gln
         665                 670                 675

 gaa caa atc ctt ccc tgc cct cag ggt act cgc ccc acc tac acc cct     2838
 Glu Gln Ile Leu Pro Cys Pro Gln Gly Thr Arg Pro Thr Tyr Thr Pro
     680                 685                 690

 tcc cca agc cca ggg cag gcc ctg ccc gtg gac cgg aag cga agc cag     2886
 Ser Pro Ser Pro Gly Gln Ala Leu Pro Val Asp Arg Lys Arg Ser Gln
 695                 700                 705                 710

 gag ccc agc cgc ccg tcc cct acg ccc cag ggc cca cct ttc ggg ggt     2934
 Glu Pro Ser Arg Pro Ser Pro Thr Pro Gln Gly Pro Pro Phe Gly Gly
                 715                 720                 725

 agc cgc acc ccc agc act tcg gac atg gcc gag gaa ggc aga gtg gcc     2982
 Ser Arg Thr Pro Ser Thr Ser Asp Met Ala Glu Glu Gly Arg Val Ala
             730                 735                 740

 agc ggg ggc ccc cca ggg ctg gag acc tcg gag tct ctc agt gac tca     3030
 Ser Gly Gly Pro Pro Gly Leu Glu Thr Ser Glu Ser Leu Ser Asp Ser
         745                 750                 755

 ctc tac gac tcg ctg tcc tct tgt ggg agt cag ggc tga                 3069
 Leu Tyr Asp Ser Leu Ser Ser Cys Gly Ser Gln Gly 
     760                 765                 770





      <210> 147
      <211> 469
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (21)..(386)

      <400> 147
 cggaattccc gggtcgagag    atg cag tcc cag ccg ggg tgg gaa gct gtg      50
                          Met Gln Ser Gln Pro Gly Trp Glu Ala Val
                            1               5                  10

 cag aca gcc ccg gat ctg gga cgt gat gga aaa ctc aac aga ctg gtt       98
 Gln Thr Ala Pro Asp Leu Gly Arg Asp Gly Lys Leu Asn Arg Leu Val
                  15                  20                  25

 cag atc ttg gcc cgg agc cca gag gca ccg ggg acc ccc agg cct gtt      146
 Gln Ile Leu Ala Arg Ser Pro Glu Ala Pro Gly Thr Pro Arg Pro Val
              30                  35                  40

 tct ccc tgg cca cac cag tac ccc act tcc aaa tgc cct gta ggt gac      194
 Ser Pro Trp Pro His Gln Tyr Pro Thr Ser Lys Cys Pro Val Gly Asp
          45                  50                  55

 cac cag gcc aca cag gcc cgt ctg agg ggc cac agg ctg tgc acc atg      242
 His Gln Ala Thr Gln Ala Arg Leu Arg Gly His Arg Leu Cys Thr Met
      60                  65                  70

 gga cgc agg cct gtc cct gcc tcc ctc cga tgt cct ctt gtt tca gga      290
 Gly Arg Arg Pro Val Pro Ala Ser Leu Arg Cys Pro Leu Val Ser Gly
  75                  80                  85                  90

 gcg cct gac agc tcc ttc ctc aga gcg tgc gtg gcc tcg tgc ctc gca      338
 Ala Pro Asp Ser Ser Phe Leu Arg Ala Cys Val Ala Ser Cys Leu Ala
                  95                 100                 105

 tct cac ctg cag ctt tca ggt agc agc aca ggg ccc agt ggg ggc tga      386
 Ser His Leu Gln Leu Ser Gly Ser Ser Thr Gly Pro Ser Gly Gly 
             110                 115                 120

 gagtttaaga tagcatgcgg acaggagctg tcatgagcac ggtggtctgg ggtctgagct    446

 gtcaggagca cgcgcggtct ggg                                            469




      <210> 148
      <211> 1413
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1413)

      <400> 148
  atg cag aaa gga aaa ggg aga aca agc cgg atc aga aga cga aaa ctc      48
  Met Gln Lys Gly Lys Gly Arg Thr Ser Arg Ile Arg Arg Arg Lys Leu
    1               5                  10                  15

 tgc gga agt tct gaa tca gaa aaa aga aac tac agt ttt agc atg cag       96
 Cys Gly Ser Ser Glu Ser Glu Lys Arg Asn Tyr Ser Phe Ser Met Gln
              20                  25                  30

 aaa gga aaa ggg aga aca agc cgg atc aga aga cga aaa ctc tgc gga      144
 Lys Gly Lys Gly Arg Thr Ser Arg Ile Arg Arg Arg Lys Leu Cys Gly
          35                  40                  45

 agt tct gaa tca aga gga gtg aat gag agc cac aag tct gaa ttt ata      192
 Ser Ser Glu Ser Arg Gly Val Asn Glu Ser His Lys Ser Glu Phe Ile
      50                  55                  60

 gag ctg agg aag tgg ctg aaa gct agg aag ttt caa gat tca aac tta      240
 Glu Leu Arg Lys Trp Leu Lys Ala Arg Lys Phe Gln Asp Ser Asn Leu
  65                  70                  75                  80

 gcg cct gct tgt ttt cca ggt aca gga aga ggg ctg atg agt caa aca      288
 Ala Pro Ala Cys Phe Pro Gly Thr Gly Arg Gly Leu Met Ser Gln Thr
                  85                  90                  95

 tcc ctg cag gag gga cag atg att att tcg ttg cct gag agt tgc ctg      336
 Ser Leu Gln Glu Gly Gln Met Ile Ile Ser Leu Pro Glu Ser Cys Leu
             100                 105                 110

 ctc acc acg gac aca gtg att cga agc tac tta ggg gca tac att act      384
 Leu Thr Thr Asp Thr Val Ile Arg Ser Tyr Leu Gly Ala Tyr Ile Thr
         115                 120                 125

 aag tgg aag cct cct cca tct cct ctg ctg gcg ctg tgc acc ttt tta      432
 Lys Trp Lys Pro Pro Pro Ser Pro Leu Leu Ala Leu Cys Thr Phe Leu
     130                 135                 140

 gtt tca gaa aag cat gct ggg cac cga tct ctt tgg aag cct tac ctg      480
 Val Ser Glu Lys His Ala Gly His Arg Ser Leu Trp Lys Pro Tyr Leu
 145                 150                 155                 160

 gag att tta ccc aag gcg tat acc tgc cct gtt tgt ttg gag ccg gaa      528
 Glu Ile Leu Pro Lys Ala Tyr Thr Cys Pro Val Cys Leu Glu Pro Glu
                 165                 170                 175

 gtg gtg aac ctt ctt ccc aaa tct tta aaa gca aag gct gaa gag cag      576
 Val Val Asn Leu Leu Pro Lys Ser Leu Lys Ala Lys Ala Glu Glu Gln
             180                 185                 190

 aga gcc cac gtg cag gag ttc ttt gct tcc tcc aga gac ttt ttc tct      624
 Arg Ala His Val Gln Glu Phe Phe Ala Ser Ser Arg Asp Phe Phe Ser
         195                 200                 205

 tct ctg cag cct ctg ttt gcg gag gct gtt gac agc atc ttc agc tac      672
 Ser Leu Gln Pro Leu Phe Ala Glu Ala Val Asp Ser Ile Phe Ser Tyr
     210                 215                 220

 agt gcc ctg ctg tgg gct tgg tgc acc gtc aac acc aga gcc gtg tac      720
 Ser Ala Leu Leu Trp Ala Trp Cys Thr Val Asn Thr Arg Ala Val Tyr
 225                 230                 235                 240

 ctg agg ccc agg cag cgg gaa tgc ctt tct gca gag ccg gac acc tgt      768
 Leu Arg Pro Arg Gln Arg Glu Cys Leu Ser Ala Glu Pro Asp Thr Cys
                 245                 250                 255

 gca ctc gct ccg tac ctg gac ctg ctg aat cat agc cca cat gtc cag      816
 Ala Leu Ala Pro Tyr Leu Asp Leu Leu Asn His Ser Pro His Val Gln
             260                 265                 270

 gta aaa gca gcg ttt aat gaa gaa act cat tct tac gaa att aga acg      864
 Val Lys Ala Ala Phe Asn Glu Glu Thr His Ser Tyr Glu Ile Arg Thr
         275                 280                 285

 act tca cgt tgg aga aag cat gaa gag gta ttc atc tgt tac ggc cct      912
 Thr Ser Arg Trp Arg Lys His Glu Glu Val Phe Ile Cys Tyr Gly Pro
     290                 295                 300

 cac gat aat caa cgg ctg ttc ctg gaa tac gga ttt gtt tct gtc cat      960
 His Asp Asn Gln Arg Leu Phe Leu Glu Tyr Gly Phe Val Ser Val His
 305                 310                 315                 320

 aat cct cat gct tgt gtt tat gtc tca aga gaa ata ctt gtt aaa tat     1008
 Asn Pro His Ala Cys Val Tyr Val Ser Arg Glu Ile Leu Val Lys Tyr
                 325                 330                 335

 ctt cca tca aca gat aaa cag atg gac aaa aag att tct att tta aag     1056
 Leu Pro Ser Thr Asp Lys Gln Met Asp Lys Lys Ile Ser Ile Leu Lys
             340                 345                 350

 gat cat ggc tat ata gaa aat ttg aca ttt gga tgg gat gga cca tct     1104
 Asp His Gly Tyr Ile Glu Asn Leu Thr Phe Gly Trp Asp Gly Pro Ser
         355                 360                 365

 tgg agg cta ctc aca gcc ctt aag ttg tta tgt ctg gaa gct gag aaa     1152
 Trp Arg Leu Leu Thr Ala Leu Lys Leu Leu Cys Leu Glu Ala Glu Lys
     370                 375                 380

 ttt aca tgc tgg aaa aaa gta ctt ctt ggg gag gta att tca gat acg     1200
 Phe Thr Cys Trp Lys Lys Val Leu Leu Gly Glu Val Ile Ser Asp Thr
 385                 390                 395                 400

 aat gag aag aca agt ttg gac ata gcc cag aaa ata tgc tat tat ttc     1248
 Asn Glu Lys Thr Ser Leu Asp Ile Ala Gln Lys Ile Cys Tyr Tyr Phe
                 405                 410                 415

 ata gaa gag act aat gct gtg ctt caa aag gtg tct cat atg aag gat     1296
 Ile Glu Glu Thr Asn Ala Val Leu Gln Lys Val Ser His Met Lys Asp
             420                 425                 430

 gaa aaa gag gcc ctg ata aac caa cta act ttg gtg gaa tcc ttg tgg     1344
 Glu Lys Glu Ala Leu Ile Asn Gln Leu Thr Leu Val Glu Ser Leu Trp
         435                 440                 445

 acg gaa gag cta aag att ctc agg gca tct gcc gag acc ctg cac agt     1392
 Thr Glu Glu Leu Lys Ile Leu Arg Ala Ser Ala Glu Thr Leu His Ser
     450                 455                 460

 ttg caa aca gct ttt acc tga                                         1413
 Leu Gln Thr Ala Phe Thr 
 465                 470





      <210> 149
      <211> 3075
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1632)..(2999)

      <400> 149
 atgctagctt tcctacttac tatcttagct tcaattttct cctttgtaaa tgggggtggt     60

 gataatagca acttgtccag ccagcttctg gcccaggaac acaactacag ctcccctgcg    120

 ggtcaccatc ctcacgtact gtacaaaagg acagcagagg agaagatcca gcggtaccgt    180

 ggctaccccg gctctggccg gaattatcct ggttactccc caagtcacat tccccatgca    240

 tctcagagtc gagagacaga gtatcaccat cgaaggttgc aaaagcagca tttttgtgga    300

 cgacgcaaga aatgtatata ttctctaata tcccttccaa atgctcttct gttcatcgta    360

 gatgctccca agcctcccac agaggacacc tatctaaggt ttgatgaata tgggagctct    420

 gggcgaccca gaagatcagc tggaaaatca caaaagggcc tcaatgtgga aaccctcgtg    480

 gtggcagaca agaaaatggt ggaaaagcat ggcaagggaa atgtcaccac atacattctc    540

 acagtaatga acatggtttc tggcctattt aaagatggga ctattggaag tgacataaac    600

 gtggttgtgg tgagcctaat tcttctggaa caagaacctg gaggattatt gatcaaccat    660

 catgcagacc agtctctgaa tagtttttgt caatggcagt ctgccctcat tggaaagaat    720

 ggcaagagac atgatcatgc catcttacta acaggatttg atatttgttc ttggaagaat    780

 gaaccatgtg acactctagg gtttgccccc atcagtggaa tgtgctctaa gtaccgaagt    840

 tgtaccatca atgaggacac aggacttggc cttgccttca ccatcgctca tgagtcaggg    900

 cacaactttg gtatgattca cgatggagaa gggaatccct gcagaaaggc tgaaggcaat    960

 atcatgtctc ccacactgac cggaaacaat ggagtgtttt catggtcttc ctgcagccgc   1020

 cagtatctca agaaattcct cagcacacct caggcggggt gtctagtgga tgagcccaag   1080

 caagcaggac agtataaata tccggacaaa ctaccaggac agatttatga tgctgacaca   1140

 cagtgtaaat ggcaatttgg agcaaaagcc aagttatgca gccttggttt tgtgaagtgg   1200

 tgtcggcaag gccagtgcgt aaagtttggg gagctcgggc cccggcccat ccacggccag   1260

 tggtccgcct ggtcgaagtg gtcagaatgt tcccggacat gtggtggagg agtcaagttc   1320

 caggagagac actgcaataa ccccaaggac cttcccaatg tccttcttca ggcatttgtt   1380

 ctcaatcggg ttagaactga cacgcctcag tatggtggct tattctgtcc aggttctagc   1440

 cgtatttatc agctgtgcaa tattaaccct tgcaatgaaa atagcttgga ttttcgggct   1500

 caacagtgtg caaatataac agcaaacctt tccgtggatg gttctaccag tggaaaccct   1560

 atacaaaagt ggaagaggaa gatcgatgca aactgtactg caaggctgag aactttgaat   1620

 ttttttttgc a atg tcc ggc aaa gtg aaa gat gga act ccc tgc tcc cca    1670
              Met Ser Gly Lys Val Lys Asp Gly Thr Pro Cys Ser Pro
                1               5                  10

 aac aaa aat gat gtt tgt att gac ggg gtt tgt gaa cta gtg gga tgt     1718
 Asn Lys Asn Asp Val Cys Ile Asp Gly Val Cys Glu Leu Val Gly Cys
      15                  20                  25

 gat cat gaa cta ggc tct aaa gca gtt tca gat gct tgt ggc gtt tgc     1766
 Asp His Glu Leu Gly Ser Lys Ala Val Ser Asp Ala Cys Gly Val Cys
  30                  35                  40                  45

 aaa ggt gat aat tca act tgc aag ttt tat aaa ggc ctg tac ctc aac     1814
 Lys Gly Asp Asn Ser Thr Cys Lys Phe Tyr Lys Gly Leu Tyr Leu Asn
                  50                  55                  60

 cag cat aaa gca aat gaa tat tat ccg gtg gtc ctc att cca gct ggc     1862
 Gln His Lys Ala Asn Glu Tyr Tyr Pro Val Val Leu Ile Pro Ala Gly
              65                  70                  75

 gcc cga agc atc gaa atc cag gag ctg cag gtt tcc tcc agt tac ctc     1910
 Ala Arg Ser Ile Glu Ile Gln Glu Leu Gln Val Ser Ser Ser Tyr Leu
          80                  85                  90

 gca gtt cga agc ctc agt caa aag tat tac ctc acc ggg ggc tgg agc     1958
 Ala Val Arg Ser Leu Ser Gln Lys Tyr Tyr Leu Thr Gly Gly Trp Ser
      95                 100                 105

 atc gac tgg cct ggg gag ttc ccc ttc gct ggg acc acg ttt gaa tac     2006
 Ile Asp Trp Pro Gly Glu Phe Pro Phe Ala Gly Thr Thr Phe Glu Tyr
 110                 115                 120                 125

 cag cgc tct ttc aac cgc ccg gaa cgt ctg tac gcg cca ggg ccc aca     2054
 Gln Arg Ser Phe Asn Arg Pro Glu Arg Leu Tyr Ala Pro Gly Pro Thr
                 130                 135                 140

 aat gag acg ctg gtc ttt gaa gta atg ccc ctt ctg tgt att cag ttc     2102
 Asn Glu Thr Leu Val Phe Glu Val Met Pro Leu Leu Cys Ile Gln Phe
             145                 150                 155

 tca gtg ctt ctt gct aca ttt ata tcg tat gac tgg atg cca ggt gaa     2150
 Ser Val Leu Leu Ala Thr Phe Ile Ser Tyr Asp Trp Met Pro Gly Glu
         160                 165                 170

 tgg agt aca tgc agc aag gcc tgt gct gga ggc cag cag agc cga aag     2198
 Trp Ser Thr Cys Ser Lys Ala Cys Ala Gly Gly Gln Gln Ser Arg Lys
     175                 180                 185

 atc cag tgt gtg caa aag aag ccc ttc caa aag gag gaa gca gtg ttg     2246
 Ile Gln Cys Val Gln Lys Lys Pro Phe Gln Lys Glu Glu Ala Val Leu
 190                 195                 200                 205

 cat tct ctc tgt cca gtg agc aca ccc act cag gtc caa gcc tgc aac     2294
 His Ser Leu Cys Pro Val Ser Thr Pro Thr Gln Val Gln Ala Cys Asn
                 210                 215                 220

 agc cat gcc tgc cct cca caa tgg agc ctt gga ccc tgg tct cag tgt     2342
 Ser His Ala Cys Pro Pro Gln Trp Ser Leu Gly Pro Trp Ser Gln Cys
             225                 230                 235

 tcc aag acc tgt gga cga ggg gtg agg aag cgt gaa ctc ctc tgc aag     2390
 Ser Lys Thr Cys Gly Arg Gly Val Arg Lys Arg Glu Leu Leu Cys Lys
         240                 245                 250

 ggc tct gcc gca gaa acc ctc ccc gag agc cag tgt acc agt ctc ccc     2438
 Gly Ser Ala Ala Glu Thr Leu Pro Glu Ser Gln Cys Thr Ser Leu Pro
     255                 260                 265

 aga cct gag ctg cag gag ggc tgt gtg ctt gga cga tgc ccc aag aac     2486
 Arg Pro Glu Leu Gln Glu Gly Cys Val Leu Gly Arg Cys Pro Lys Asn
 270                 275                 280                 285

 agc cgg cta cag tgg gtc gct tct tcg tgg agc gag tgt tct gca acc     2534
 Ser Arg Leu Gln Trp Val Ala Ser Ser Trp Ser Glu Cys Ser Ala Thr
                 290                 295                 300

 tgt ggt ttg ggt gtg agg aag agg gag atg aag tgc agc gag aag ggc     2582
 Cys Gly Leu Gly Val Arg Lys Arg Glu Met Lys Cys Ser Glu Lys Gly
             305                 310                 315

 ttc cag gga aag ctg ata act ttc cca gag cga aga tgc cgt aat att     2630
 Phe Gln Gly Lys Leu Ile Thr Phe Pro Glu Arg Arg Cys Arg Asn Ile
         320                 325                 330

 aag aaa cca aat ctg gac ttg gaa gag acc tgc aac cga cgg gct tgc     2678
 Lys Lys Pro Asn Leu Asp Leu Glu Glu Thr Cys Asn Arg Arg Ala Cys
     335                 340                 345

 cca gcc cat cca gtg tac aac atg gta gct gga tgg tat tca ttg ccg     2726
 Pro Ala His Pro Val Tyr Asn Met Val Ala Gly Trp Tyr Ser Leu Pro
 350                 355                 360                 365

 tgg cag cag tgc aca gtc acc tgt ggg gga ggg gtc cag acc cgg tca     2774
 Trp Gln Gln Cys Thr Val Thr Cys Gly Gly Gly Val Gln Thr Arg Ser
                 370                 375                 380

 gtc cac tgt gtt cag caa ggc cgg cct tcc tca agt tgt ctg ctc cat     2822
 Val His Cys Val Gln Gln Gly Arg Pro Ser Ser Ser Cys Leu Leu His
             385                 390                 395

 cag aaa cct ccg gtg cta cga gcc tgt aat aca aac ttc tgt cca gct     2870
 Gln Lys Pro Pro Val Leu Arg Ala Cys Asn Thr Asn Phe Cys Pro Ala
         400                 405                 410

 cct gaa aag aga gag gat cca tcc tgc gta gat ttc ttc aac tgg tgt     2918
 Pro Glu Lys Arg Glu Asp Pro Ser Cys Val Asp Phe Phe Asn Trp Cys
     415                 420                 425

 cac cta gtt cct cag cat ggt gtc tgc aac cac aag ttt tac gga aaa     2966
 His Leu Val Pro Gln His Gly Val Cys Asn His Lys Phe Tyr Gly Lys
 430                 435                 440                 445

 caa tgc tgc aag tca tgc aca agg aag atc tga tcttggtg tcctccccag     3017
 Gln Cys Cys Lys Ser Cys Thr Arg Lys Ile 
                 450                 455

 caccttaggg ccaggggctt acctttcaac ctctagagag accacctgcc tttgagag     3075




      <210> 150
      <211> 696
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(696)

      <400> 150
  atg gga gtg gac atc cgc cat aac aag gac cga aag gtt cgg cgc aag      48
  Met Gly Val Asp Ile Arg His Asn Lys Asp Arg Lys Val Arg Arg Lys
    1               5                  10                  15

 gag ccc aag agc cag gat atc tac ctg agg ctg ttg gtc aag tta tac       96
 Glu Pro Lys Ser Gln Asp Ile Tyr Leu Arg Leu Leu Val Lys Leu Tyr
              20                  25                  30

 agg ttt ctg gcc aga aga acc aac tcc aca ttc aac cag gtt gtg ttg      144
 Arg Phe Leu Ala Arg Arg Thr Asn Ser Thr Phe Asn Gln Val Val Leu
          35                  40                  45

 aag agg ttg ttt atg agt cgc acc aac cgg ccg cct ctg tcc ctt tcc      192
 Lys Arg Leu Phe Met Ser Arg Thr Asn Arg Pro Pro Leu Ser Leu Ser
      50                  55                  60

 cgg atg atc cgg aag atg aag ctt cct ggc cgg gaa aac aag acg gcc      240
 Arg Met Ile Arg Lys Met Lys Leu Pro Gly Arg Glu Asn Lys Thr Ala
  65                  70                  75                  80

 gtg gtt gtg ggg acc ata act gat gat gtg cgg gtt cag gag gta ccc      288
 Val Val Val Gly Thr Ile Thr Asp Asp Val Arg Val Gln Glu Val Pro
                  85                  90                  95

 aaa ctg aag cat aac acc agg gat gtg gtg gtg aaa gtt ccg gaa gtg      336
 Lys Leu Lys His Asn Thr Arg Asp Val Val Val Lys Val Pro Glu Val
             100                 105                 110

 ttg aga act gct gct gtc agc cca ggg gtg ctc cgg gta gta aac gat      384
 Leu Arg Thr Ala Ala Val Ser Pro Gly Val Leu Arg Val Val Asn Asp
         115                 120                 125

 agt gtt ggt tac cag ggc tct gct gcg cca agg cag tgg agg gta tgt      432
 Ser Val Gly Tyr Gln Gly Ser Ala Ala Pro Arg Gln Trp Arg Val Cys
     130                 135                 140

 gca ctg cgc gtg acc agc cgg gcc cgc agc cgc atc ctc agg gca ggg      480
 Ala Leu Arg Val Thr Ser Arg Ala Arg Ser Arg Ile Leu Arg Ala Gly
 145                 150                 155                 160

 ggc aag atc ctc act ttc gac cag ctg gcc ctg gac tcc cct aag ggc      528
 Gly Lys Ile Leu Thr Phe Asp Gln Leu Ala Leu Asp Ser Pro Lys Gly
                 165                 170                 175

 tgt ggc act gtc ctg ctc tcc ggt cct cgc aag ggc cga gag gtg tac      576
 Cys Gly Thr Val Leu Leu Ser Gly Pro Arg Lys Gly Arg Glu Val Tyr
             180                 185                 190

 cgg cat ttc ggc aag gcc cca gga acc ccg cac agc cac acc aaa ccc      624
 Arg His Phe Gly Lys Ala Pro Gly Thr Pro His Ser His Thr Lys Pro
         195                 200                 205

 tac gtc cgc tcc aag ggc cgg aag ttc gag cgt gcc aga ggc cga cgg      672
 Tyr Val Arg Ser Lys Gly Arg Lys Phe Glu Arg Ala Arg Gly Arg Arg
     210                 215                 220

 gcc agc cga ggc tac aaa aac taa                                      696
 Ala Ser Arg Gly Tyr Lys Asn 
 225                 230





      <210> 151
      <211> 436
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (125)..(436)

      <400> 151
 accctcgatc acttctgcag atatagaaaa gacctctgac catcaatagt agctgtctca     60

 gagttcctga taagagctca tcctctgaag cggtgcgtct gggcctgacc ctgggagccg    120

 ggcc atg ttg gat gcc atc atg aag gcg gat gcg ggg tta cat ggg gaa     169
      Met Leu Asp Ala Ile Met Lys Ala Asp Ala Gly Leu His Gly Glu
        1               5                  10                  15

 ggg cat cag gaa ggc tgg gag gaa ggc agg agc gtg ggc gtc act gaa      217
 Gly His Gln Glu Gly Trp Glu Glu Gly Arg Ser Val Gly Val Thr Glu
                  20                  25                  30

 gga agg cag cac cgc agg gtg cac gga gcc aac atc cgg cct gag atc      265
 Gly Arg Gln His Arg Arg Val His Gly Ala Asn Ile Arg Pro Glu Ile
              35                  40                  45

 agg tgc tat caa ggc ttt gct ttt gca tgg gga tgt ctc ttg cac agc      313
 Arg Cys Tyr Gln Gly Phe Ala Phe Ala Trp Gly Cys Leu Leu His Ser
          50                  55                  60

 tgg gcc act cag aag gac cgc aga aag atg tgg ttc tta gaa tca ctg      361
 Trp Ala Thr Gln Lys Asp Arg Arg Lys Met Trp Phe Leu Glu Ser Leu
      65                  70                  75

 att gga atg att cag aaa ttc ctt tat gag gat cct gct tat gat gag      409
 Ile Gly Met Ile Gln Lys Phe Leu Tyr Glu Asp Pro Ala Tyr Asp Glu
  80                  85                  90                  95

 ctc cat gaa gac tta gag gaa aat tga                                  436
 Leu His Glu Asp Leu Glu Glu Asn 
                 100





      <210> 152
      <211> 696
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (253)..(414)

      <400> 152
 tgggttgcaa tggtgcataa gatgctctga aaaagtgcta tgactagagc ttaaaatgac     60

 aggtctagcc aagacaatca actcaatctc caggatcagt ctctggaagg ctgccggagg    120

 ggagaattca gaaaagcgac tgccaaaaac agcagaacca gtccacgtgc ccccagctgg    180

 aaaccccttt ctgggcccaa ggggcagcat tatgtttccc agggtggtga taaaccttcc    240

 ggtacatatc cc    atg gga aaa cat ttg ggc aag cag cag cac ctt gtc     288
                  Met Gly Lys His Leu Gly Lys Gln Gln His Leu Val
                    1               5                  10

 ctg gtc cct gag gag agc agt gac cat gtg gca tgg agg atc ctg ggg      336
 Leu Val Pro Glu Glu Ser Ser Asp His Val Ala Trp Arg Ile Leu Gly
          15                  20                  25

 tat aga gac cct gat gct gga tcc cgg acc cca agg atg agt gag gtc      384
 Tyr Arg Asp Pro Asp Ala Gly Ser Arg Thr Pro Arg Met Ser Glu Val
      30                  35                  40

 agc acc cat gtg cca aga aag gac aaa tga t gactgcgaaa gactgaggtc      435
 Ser Thr His Val Pro Arg Lys Asp Lys 
  45                  50

 aggcaggaac tgtagcagct caggagggct tgttcctcat gatccctgcg aacaggaggg    495

 ctcagacatg cttccaggag gccaaggcat tgccaaagtc ctgccttgtt tcaggactct    555

 gtgtacttgc tggttttggc aataaagatg gcttgtaata ttctcagagt tgactgcccc    615

 attgggaatg gtagcttgca gcaaagcctt cttaaaaaca caaatttggg aagtcaatga    675

 gattttgaat cttgaaatta t                                              696




      <210> 153
      <211> 846
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(846)

      <400> 153
  atg ctc agc gct gcc ccg gag cct ccg ccg cgc ccg cct ccc gcc ctc      48
  Met Leu Ser Ala Ala Pro Glu Pro Pro Pro Arg Pro Pro Pro Ala Leu
    1               5                  10                  15

 tcc cca ccg ggc tcg ggc cca ggc tcg ggc tcc cgc cat ggc tcg gct       96
 Ser Pro Pro Gly Ser Gly Pro Gly Ser Gly Ser Arg His Gly Ser Ala
              20                  25                  30

 cgt ccc ggt cct acc cca gag ccg tcg ggg agc ctg ggc gcg gcg ctc      144
 Arg Pro Gly Pro Thr Pro Glu Pro Ser Gly Ser Leu Gly Ala Ala Leu
          35                  40                  45

 gac agc agc ctg cgt gcc gcc gtg gcg ttc aag gca gag ggc cag cgc      192
 Asp Ser Ser Leu Arg Ala Ala Val Ala Phe Lys Ala Glu Gly Gln Arg
      50                  55                  60

 tgc tat cga gag aag aag ttc cgg gag gcc atc ggc aag tac cac cga      240
 Cys Tyr Arg Glu Lys Lys Phe Arg Glu Ala Ile Gly Lys Tyr His Arg
  65                  70                  75                  80

 gcg ctg ctg cag ctg aag gcg gcg cag ggg gcc cgc cct agc ggc ctg      288
 Ala Leu Leu Gln Leu Lys Ala Ala Gln Gly Ala Arg Pro Ser Gly Leu
                  85                  90                  95

 ccc gcc ccc gcc ccc ggg ccc acc agc agc ccc ggg ccg gcg cgc ctc      336
 Pro Ala Pro Ala Pro Gly Pro Thr Ser Ser Pro Gly Pro Ala Arg Leu
             100                 105                 110

 agc gag gag cag cgg cgc ctg gtg gag agc acg gag gtg gag tgt tac      384
 Ser Glu Glu Gln Arg Arg Leu Val Glu Ser Thr Glu Val Glu Cys Tyr
         115                 120                 125

 gac tcc ctc acg ggt acg ccg tcg ggg ggc gag cgg att ggc gcc cct      432
 Asp Ser Leu Thr Gly Thr Pro Ser Gly Gly Glu Arg Ile Gly Ala Pro
     130                 135                 140

 ggt tgc cgg agc aat ccc tta ggc ctg gtt ccc tgc cgc ctg gag cct      480
 Gly Cys Arg Ser Asn Pro Leu Gly Leu Val Pro Cys Arg Leu Glu Pro
 145                 150                 155                 160

 cgg ctc ctc gca gtc agg tgg gtt ctg ggg gtg cca gca ggc tct gag      528
 Arg Leu Leu Ala Val Arg Trp Val Leu Gly Val Pro Ala Gly Ser Glu
                 165                 170                 175

 agt gcc ggc cgc ggg gcc ctc gca gct tgc ctg ctg cag tcg gag ctg      576
 Ser Ala Gly Arg Gly Ala Leu Ala Ala Cys Leu Leu Gln Ser Glu Leu
             180                 185                 190

 gta aac tac gag cgc gtg cgc gag tac tgt ctc aag gta ctg gag aag      624
 Val Asn Tyr Glu Arg Val Arg Glu Tyr Cys Leu Lys Val Leu Glu Lys
         195                 200                 205

 cag cag ggc aac ttc aag gcc acc tac cgt gcc ggc att gcc ttc tac      672
 Gln Gln Gly Asn Phe Lys Ala Thr Tyr Arg Ala Gly Ile Ala Phe Tyr
     210                 215                 220

 cac ctg ggc gac tac gca cgc gcg ctg cgc tac ctg cag gag gcc cgc      720
 His Leu Gly Asp Tyr Ala Arg Ala Leu Arg Tyr Leu Gln Glu Ala Arg
 225                 230                 235                 240

 agc cgg gaa ccc aca gac acc aat gtg ctc cgc tac atc cag ctg act      768
 Ser Arg Glu Pro Thr Asp Thr Asn Val Leu Arg Tyr Ile Gln Leu Thr
                 245                 250                 255

 cag ctg aag atg aat cgt tgc agc ctc cag cgg gaa gac agt ggg gct      816
 Gln Leu Lys Met Asn Arg Cys Ser Leu Gln Arg Glu Asp Ser Gly Ala
             260                 265                 270

 ggg tcc cag act cgg gat gta att ggc tga                              846
 Gly Ser Gln Thr Arg Asp Val Ile Gly 
         275                 280





      <210> 154
      <211> 2469
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1034)..(2422)

      <400> 154
 tgtacaccca cccactagta gaaggactgt acttcataca gactgataca acattttcca     60

 gacagctgag cttgcatgaa gtcctttatg cttgccattt ccccctccct gggtaaggct    120

 gcttttctct tctggagctg gtcacctgtc cctccccact gatgaccatg agttacagtt    180

 ggcatcacct tgctctggta tggccacctc tgtccacctc tgtctcctct agctgctcca    240

 tggcaagtcc ccagccccag ttcccttctg ccggcatggt cctggtcaaa gtgatggtcc    300

 cgagaaagct ttggtcgact ttagctgtag ggtgcctgcg actctatggt gatggacgga    360

 ggcctgaccc aatggaaaga ggagctgtcc caaggccagg caatcatata cgactactgg    420

 agctggcaga gcccgccctc tttccacttg gacctgaata acccgaccca aaccgagttt    480

 cgcccggaga gactgcgctt tcggccaatg agtgcgtcga tttcgagccc cagtgtgagc    540

 gaaggcggga caagtctcca tggcagcgac taaaggacag cgatgtgaac cactgacaac    600

 agttcgcggc gtttgacggc ggcgggggcg tggcggggtt ttatctgtgt attgacgaga    660

 gccgggcgcg gagggaaaga gtggggcttg gccaatggga gcgccgtgag cttcgtagca    720

 acggaggagt ggcggtggct gtggccaata gaaagcctca gtggccttgg cggggctggc    780

 ccggagagca gatgggaggt gcggcgacag tgtttgacga gagccgaagg aggctgtggg    840

 aggtgttggc ggcggcggcg cgggcgcctg aggaggagga ggagaagcgg atgagatcgt    900

 ggggctcacc agcgtccccc atggcttctg agtagcgtgg gagtggagtc agcaccaagc    960

 caggctcccc gcgcctgcct tgccctcacc tgctcctgct ctctgccaga ggcagcatgg   1020

 tccgcagggc acc   atg ggg ccc gac aga gtg aca gca cga gaa ctg tgc    1069
                  Met Gly Pro Asp Arg Val Thr Ala Arg Glu Leu Cys
                    1               5                  10

 gag aac gac gac ctg gcc acc agc ctc gtc ctg gac ccc tac ctc ggt     1117
 Glu Asn Asp Asp Leu Ala Thr Ser Leu Val Leu Asp Pro Tyr Leu Gly
          15                  20                  25

 ttc cgc acc cat aag atg aac gtc agc cct gtg ccc ccc ctg cgg cga     1165
 Phe Arg Thr His Lys Met Asn Val Ser Pro Val Pro Pro Leu Arg Arg
      30                  35                  40

 cag cag cac ctg cgc tca gcg ctg gaa act ttc ctg agg cag cgg gac     1213
 Gln Gln His Leu Arg Ser Ala Leu Glu Thr Phe Leu Arg Gln Arg Asp
  45                  50                  55                  60

 ctg gag gct gcg tac cgg gcc ctg acg ctg gga ggc tgg acg gcc cgc     1261
 Leu Glu Ala Ala Tyr Arg Ala Leu Thr Leu Gly Gly Trp Thr Ala Arg
                  65                  70                  75

 tac ttc cag agc cgg ggc ccg cgg cag gag gct gcc ctc aag acc cac     1309
 Tyr Phe Gln Ser Arg Gly Pro Arg Gln Glu Ala Ala Leu Lys Thr His
              80                  85                  90

 gtc tat cgc tac ctc cgt gcc ttc ctg ccg gaa agt ggc ttt acc atc     1357
 Val Tyr Arg Tyr Leu Arg Ala Phe Leu Pro Glu Ser Gly Phe Thr Ile
          95                 100                 105

 ctg ccc tgc acg cgc tac tcc atg gag acc aac ggg gcc aag atc gtg     1405
 Leu Pro Cys Thr Arg Tyr Ser Met Glu Thr Asn Gly Ala Lys Ile Val
     110                 115                 120

 tcc act cgt gct tgg aaa aag aat gag aag ctg gag ctg ctg gtg ggc     1453
 Ser Thr Arg Ala Trp Lys Lys Asn Glu Lys Leu Glu Leu Leu Val Gly
 125                 130                 135                 140

 tgc att gca gag ctg cgg gag gca gat gag ggg ctg ctg agg gcc ggt     1501
 Cys Ile Ala Glu Leu Arg Glu Ala Asp Glu Gly Leu Leu Arg Ala Gly
                 145                 150                 155

 gag aat gac ttc agc atc atg tac tca acc cgc aag cgg agt gct cag     1549
 Glu Asn Asp Phe Ser Ile Met Tyr Ser Thr Arg Lys Arg Ser Ala Gln
             160                 165                 170

 ctg tgg ctg ggc cca gcc gcc ttc atc aac cat gac tgc aaa ccc aac     1597
 Leu Trp Leu Gly Pro Ala Ala Phe Ile Asn His Asp Cys Lys Pro Asn
         175                 180                 185

 tgc aag ttt gtg cct gca gat ggg aac gca gcc tgc gtg aag gtg ctc     1645
 Cys Lys Phe Val Pro Ala Asp Gly Asn Ala Ala Cys Val Lys Val Leu
     190                 195                 200

 cgg gac att gag cct ggg gac gag gtg aca tgc ttc tac ggc gag ggc     1693
 Arg Asp Ile Glu Pro Gly Asp Glu Val Thr Cys Phe Tyr Gly Glu Gly
 205                 210                 215                 220

 ttc ttc ggc gag aag aat gag cac tgt gaa tgc cac acc tgt gag agg     1741
 Phe Phe Gly Glu Lys Asn Glu His Cys Glu Cys His Thr Cys Glu Arg
                 225                 230                 235

 aaa ggt gaa gga gct ttc cga acc agg cct agg gag ccc gcg ttg cca     1789
 Lys Gly Glu Gly Ala Phe Arg Thr Arg Pro Arg Glu Pro Ala Leu Pro
             240                 245                 250

 cca cgg ccc ctg gac aag tac cag ctg cgt gag acc aag cgg cgg ctg     1837
 Pro Arg Pro Leu Asp Lys Tyr Gln Leu Arg Glu Thr Lys Arg Arg Leu
         255                 260                 265

 cag caa ggc ctg gac agt ggc agc cga cag ggc ctg ctg ggc cct cgg     1885
 Gln Gln Gly Leu Asp Ser Gly Ser Arg Gln Gly Leu Leu Gly Pro Arg
     270                 275                 280

 gcc tgc gtg cac cca tcc ccg ctg cgc cgg gac cca ttc tgc gcc gcc     1933
 Ala Cys Val His Pro Ser Pro Leu Arg Arg Asp Pro Phe Cys Ala Ala
 285                 290                 295                 300

 tgc cag ccc ctg cgc ctg cca gcc tgc agc gcc cgc cca gac acc tca     1981
 Cys Gln Pro Leu Arg Leu Pro Ala Cys Ser Ala Arg Pro Asp Thr Ser
                 305                 310                 315

 ccc ctc tgg ctc cag tgg ctg cct cag ccc cag ccc cga gtg cgg ccc     2029
 Pro Leu Trp Leu Gln Trp Leu Pro Gln Pro Gln Pro Arg Val Arg Pro
             320                 325                 330

 cgg aag cgc cga cgc ccc cgg ccc cgg agg gcc cca gtg ctc tcc acc     2077
 Arg Lys Arg Arg Arg Pro Arg Pro Arg Arg Ala Pro Val Leu Ser Thr
         335                 340                 345

 cac cac gct gcc cgc gtc tcc ctg cac cga tgg gga ggc tgt ggc ccc     2125
 His His Ala Ala Arg Val Ser Leu His Arg Trp Gly Gly Cys Gly Pro
     350                 355                 360

 cac tgc cgc ctg cga gga gag gcc ctg gtg gcc ctg ggc cag ccc ccc     2173
 His Cys Arg Leu Arg Gly Glu Ala Leu Val Ala Leu Gly Gln Pro Pro
 365                 370                 375                 380

 cac gcc cgc tgg gcc cct cag cag gac tgg cac tgg gcc cgg cgc tat     2221
 His Ala Arg Trp Ala Pro Gln Gln Asp Trp His Trp Ala Arg Arg Tyr
                 385                 390                 395

 ggg ctg cct tac gtg gtg cgt gtg gac ctt cgt cgc ctg gcc cca gcc     2269
 Gly Leu Pro Tyr Val Val Arg Val Asp Leu Arg Arg Leu Ala Pro Ala
             400                 405                 410

 cca cca gct acc cca gcc cct gct ggg acc cca ggc ccc atc ctg atc     2317
 Pro Pro Ala Thr Pro Ala Pro Ala Gly Thr Pro Gly Pro Ile Leu Ile
         415                 420                 425

 ccg aag cag gcc ctc gcc ttc gcc ccc ttc tcc cca ccc aag cgc cta     2365
 Pro Lys Gln Ala Leu Ala Phe Ala Pro Phe Ser Pro Pro Lys Arg Leu
     430                 435                 440

 cgg ctg gtg gtc agc cac ggc tcc atc gac ctg gat gtc ggc ggt gaa     2413
 Arg Leu Val Val Ser His Gly Ser Ile Asp Leu Asp Val Gly Gly Glu
 445                 450                 455                 460

 gag ctg tga caggccg gacggggagg cccagcaggg agagagggtc tctctcctag     2469
 Glu Leu 






      <210> 155
      <211> 2325
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (141)..(1409)

      <400> 155
 ggtctggcgg gagcgcgggg gtttttctgc tgccgcttcc tttctgccct tttaatttcc     60

 ccgaaatcag actgctgcct tggaccggga cagctcgcgg cccccgagag ctctagccgt    120

 cgaggagctg cctggggacg    atg agg aaa tgg agg cac aga gag gtg aac     170
                          Met Arg Lys Trp Arg His Arg Glu Val Asn
                            1               5                  10

 ttg ccc gaa gtc act cag cag gat gca gtg tgt cca gct cca ata ccg      218
 Leu Pro Glu Val Thr Gln Gln Asp Ala Val Cys Pro Ala Pro Ile Pro
                  15                  20                  25

 agc cca ggt ctg agt gcc cag aca gga ctc cag aag att tgg gga act      266
 Ser Pro Gly Leu Ser Ala Gln Thr Gly Leu Gln Lys Ile Trp Gly Thr
              30                  35                  40

 atc cac tgc caa gtt tgc cct ggg gcc cca gcc tgg ccc ggg tca ccc      314
 Ile His Cys Gln Val Cys Pro Gly Ala Pro Ala Trp Pro Gly Ser Pro
          45                  50                  55

 tgg cat gag gag atg ggc ctg ttg ctc ctg gtc ccg ttg ctc ctg ctg      362
 Trp His Glu Glu Met Gly Leu Leu Leu Leu Val Pro Leu Leu Leu Leu
      60                  65                  70

 ccc ggc tcc tac gga ctg ccc ttc tac aac ggc ttc tac tac tcc aac      410
 Pro Gly Ser Tyr Gly Leu Pro Phe Tyr Asn Gly Phe Tyr Tyr Ser Asn
  75                  80                  85                  90

 agc gcc aac gac cag aac cta ggc aac ggt cat ggc aaa gac ctc ctt      458
 Ser Ala Asn Asp Gln Asn Leu Gly Asn Gly His Gly Lys Asp Leu Leu
                  95                 100                 105

 aat gga gtg aag ctg gtg gtg gag aca ccc gag gag acc ctg ttc acc      506
 Asn Gly Val Lys Leu Val Val Glu Thr Pro Glu Glu Thr Leu Phe Thr
             110                 115                 120

 tac caa ggg gcc agt gtg atc ctg ccc tgc cgc tac cgc tac gag ccg      554
 Tyr Gln Gly Ala Ser Val Ile Leu Pro Cys Arg Tyr Arg Tyr Glu Pro
         125                 130                 135

 gcc ctg gtc tcc ccg cgg cgt gtg cgt gtc aaa tgg tgg aag ctg tcg      602
 Ala Leu Val Ser Pro Arg Arg Val Arg Val Lys Trp Trp Lys Leu Ser
     140                 145                 150

 gag aac ggg gcc cca gag aag gac gtg ctg gtg gcc atc ggg ctg agg      650
 Glu Asn Gly Ala Pro Glu Lys Asp Val Leu Val Ala Ile Gly Leu Arg
 155                 160                 165                 170

 cac cgc tcc ttt ggg gac tac caa ggc cgc gtg cac ctg cgg cag gac      698
 His Arg Ser Phe Gly Asp Tyr Gln Gly Arg Val His Leu Arg Gln Asp
                 175                 180                 185

 aaa gag cat gac gtc tcg ctg gag atc cag gat ctg cgg ctg gag gac      746
 Lys Glu His Asp Val Ser Leu Glu Ile Gln Asp Leu Arg Leu Glu Asp
             190                 195                 200

 tat ggg cgt tac cgc tgt gag gtc att gac ggg ctg gag gat gaa agc      794
 Tyr Gly Arg Tyr Arg Cys Glu Val Ile Asp Gly Leu Glu Asp Glu Ser
         205                 210                 215

 ggt ctg gtg gag ctg gag ctg cgg ggt gtg gtc ttt cct tac cag tcc      842
 Gly Leu Val Glu Leu Glu Leu Arg Gly Val Val Phe Pro Tyr Gln Ser
     220                 225                 230

 ccc aac ggg cgc tac cag ttc aac ttc cac gag ggc cag cag gtc tgt      890
 Pro Asn Gly Arg Tyr Gln Phe Asn Phe His Glu Gly Gln Gln Val Cys
 235                 240                 245                 250

 gca gag cag gct gcg gtg gtg gcc tcc ttt gag cag ctc ttc cgg gcc      938
 Ala Glu Gln Ala Ala Val Val Ala Ser Phe Glu Gln Leu Phe Arg Ala
                 255                 260                 265

 tgg gag gag ggc ctg gac tgg tgc aac gcg ggc tgg ctg cag gat gcc      986
 Trp Glu Glu Gly Leu Asp Trp Cys Asn Ala Gly Trp Leu Gln Asp Ala
             270                 275                 280

 acg gtg cag tac ccc atc atg ttg ccc cgg cag ccc tgc ggt ggc ccg     1034
 Thr Val Gln Tyr Pro Ile Met Leu Pro Arg Gln Pro Cys Gly Gly Pro
         285                 290                 295

 ggc ctg gca cct ggc gtg cga agc tac ggc ccc cgc cac cgc cgc ctg     1082
 Gly Leu Ala Pro Gly Val Arg Ser Tyr Gly Pro Arg His Arg Arg Leu
     300                 305                 310

 cac cgc tat gat gta ttc tgc ttc gct act gcc ctc aag ggg cgg gtg     1130
 His Arg Tyr Asp Val Phe Cys Phe Ala Thr Ala Leu Lys Gly Arg Val
 315                 320                 325                 330

 tac tac ctg gag cac cct gag aag ctg acg ctg aca gag gca agg gag     1178
 Tyr Tyr Leu Glu His Pro Glu Lys Leu Thr Leu Thr Glu Ala Arg Glu
                 335                 340                 345

 gcc tgc cag gaa gat gat gcc acg atc gcc aag gtg gga cag ctc ttt     1226
 Ala Cys Gln Glu Asp Asp Ala Thr Ile Ala Lys Val Gly Gln Leu Phe
             350                 355                 360

 gcc gcc tgg aag ttc cat ggc ctg gac cgc tgc gac gct ggc tgg ctg     1274
 Ala Ala Trp Lys Phe His Gly Leu Asp Arg Cys Asp Ala Gly Trp Leu
         365                 370                 375

 gca gat ggt agc gtc cgc tac cct gtg gtt cac ccg cat cct aac tgt     1322
 Ala Asp Gly Ser Val Arg Tyr Pro Val Val His Pro His Pro Asn Cys
     380                 385                 390

 ggg ccc cca gag cct ggg gtc cga agc ttt ggc ttc ccc gac ccg cag     1370
 Gly Pro Pro Glu Pro Gly Val Arg Ser Phe Gly Phe Pro Asp Pro Gln
 395                 400                 405                 410

 agc cgc ttg tac ggt gtt tac tgc tac cgc cag cac tag gacctggggc      1419
 Ser Arg Leu Tyr Gly Val Tyr Cys Tyr Arg Gln His 
                 415                 420

 cctcccctgc cgcattccct cactggctgt gtatttattg agtggttcgt tttcccttgt   1479

 gggttggagc cattttaact gtttttatac ttctcaattt aaattttctt taaacatttt   1539

 tttactattt tttgtaaagc aaacagaacc caatgcctcc ctttgctcct ggatgcccca   1599

 ctccaggaat catgcttgct cccctgggcc atttgcggtt ttgtgggctt ctggagggtt   1659

 ccccgccatc caggctggtc tccctccctt aaggaggttg gtgcccagag tgggcggtgg   1719

 cctgtctaga atgccgccgg gagtccgggc atggtgggca cagttctccc tgcccctcag   1779

 cctgggggaa gaagagggcc tcgggggcct ccggagctgg gctttgggcc tctcctgccc   1839

 acctctactt ctctgtgaag ccgctgaccc cagtctgccc actgaggggc tagggctgga   1899

 agccagttct aggcttccag gcgaaagctg agggaaggaa gaaactcccc tccccgttcc   1959

 ccttcccctc tcggttccaa agaatctgtt ttgttgtcat ttgtttctcc tgtttccctg   2019

 tgtggggagg ggccctcagg tgtgtgtact ttggacaata aatggtgcta tgactgcctt   2079

 ccgccaaaaa aaaaaaaaaa agcgcccgtt caatttaaaa ggccccgtta aaccccgttg   2139

 aaaaccctaa aggggccctc ctttaatcca acccggttaa aaaaaaatta accccgaagg   2199

 ttttttttta aaaaatggaa aaccagggtt gatttaaaaa atccaaaagg ggtttaagaa   2259

 aactaaccca accctatacc acccagggga actttcctgt ttttgaaccc attttaataa   2319

 tcttgt                                                              2325




      <210> 156
      <211> 624
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(624)

      <400> 156
  atg aac tgt gaa act ata aaa tca cca act gac act cag aag aga gtg      48
  Met Asn Cys Glu Thr Ile Lys Ser Pro Thr Asp Thr Gln Lys Arg Val
    1               5                  10                  15

 tca gtt gtc ccc cgt ttt ata aat tct cag aaa agg aga aca cat gaa       96
 Ser Val Val Pro Arg Phe Ile Asn Ser Gln Lys Arg Arg Thr His Glu
              20                  25                  30

 gca aaa ggt ttc ata aat aaa gat gta tcg gac cct atc ttt tca cta      144
 Ala Lys Gly Phe Ile Asn Lys Asp Val Ser Asp Pro Ile Phe Ser Leu
          35                  40                  45

 gag ggc act caa tct cct ctt cat tgg aac ttt aag aaa aat ata tgg      192
 Glu Gly Thr Gln Ser Pro Leu His Trp Asn Phe Lys Lys Asn Ile Trp
      50                  55                  60

 gaa caa gag aat cac ccg ttc aac tta caa tat ggt gca cag cag act      240
 Glu Gln Glu Asn His Pro Phe Asn Leu Gln Tyr Gly Ala Gln Gln Thr
  65                  70                  75                  80

 gca tgt aac aaa ttg tac tct cag aaa ggt aat tta ttc act gat cag      288
 Ala Cys Asn Lys Leu Tyr Ser Gln Lys Gly Asn Leu Phe Thr Asp Gln
                  85                  90                  95

 caa aaa tgt cta tca gat gag tct gaa ggc ctc aca tgt gaa agt tca      336
 Gln Lys Cys Leu Ser Asp Glu Ser Glu Gly Leu Thr Cys Glu Ser Ser
             100                 105                 110

 aaa gat gag act ttc tgg aga gaa tta cca tct gtc ccc agt ttg gat      384
 Lys Asp Glu Thr Phe Trp Arg Glu Leu Pro Ser Val Pro Ser Leu Asp
         115                 120                 125

 tta ttt cgt gct tct gat tct aat gca aat caa aaa gaa ttc aac agc      432
 Leu Phe Arg Ala Ser Asp Ser Asn Ala Asn Gln Lys Glu Phe Asn Ser
     130                 135                 140

 ctt tat ttc tac caa aga gct gga aaa agt tta gga cag aaa agg cac      480
 Leu Tyr Phe Tyr Gln Arg Ala Gly Lys Ser Leu Gly Gln Lys Arg His
 145                 150                 155                 160

 cat gaa tct tca ttt aac tca gga gac aag gaa tca tta aca ggt ttt      528
 His Glu Ser Ser Phe Asn Ser Gly Asp Lys Glu Ser Leu Thr Gly Phe
                 165                 170                 175

 atg tgc tca caa cta cca caa ttc aaa aaa cga cgt cta gca tat gaa      576
 Met Cys Ser Gln Leu Pro Gln Phe Lys Lys Arg Arg Leu Ala Tyr Glu
             180                 185                 190

 aaa gtc cct ggt aga gtt gat ggg cag act cgg ctg agg ttt ttt tga      624
 Lys Val Pro Gly Arg Val Asp Gly Gln Thr Arg Leu Arg Phe Phe 
         195                 200                 205





      <210> 157
      <211> 1674
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (106)..(1674)

      <400> 157
 cggccccccc cggccacggc gcaccgcctc cccgcccccg cccgccctcc cccaccgcgc     60

 gcgctccgcc cgccccggag cctcgccctc cgccacgatg agcaa    atg agc gcg     114
                                                      Met Ser Ala
                                                        1

 agc gag ggc atg aaa ttt aaa ttc cac tca ggg gag aaa gtg ctg tgc      162
 Ser Glu Gly Met Lys Phe Lys Phe His Ser Gly Glu Lys Val Leu Cys
       5                  10                  15

 ttc gag cct gac ccc acc aag gcg cga gtg ctg tac gat gcc aag att      210
 Phe Glu Pro Asp Pro Thr Lys Ala Arg Val Leu Tyr Asp Ala Lys Ile
  20                  25                  30                  35

 gtt gat gtt att gtt ggg aaa gac gaa aaa ggc aga aag atc cca gaa      258
 Val Asp Val Ile Val Gly Lys Asp Glu Lys Gly Arg Lys Ile Pro Glu
                  40                  45                  50

 tat ctg atc cat ttt aat ggt tgg aac aga agc tgg gat aga tgg gca      306
 Tyr Leu Ile His Phe Asn Gly Trp Asn Arg Ser Trp Asp Arg Trp Ala
              55                  60                  65

 gca gaa gat cat gtg ctt cgt gat acc gat gaa aat cgt aga tta cag      354
 Ala Glu Asp His Val Leu Arg Asp Thr Asp Glu Asn Arg Arg Leu Gln
          70                  75                  80

 cgt aaa ttg gca aga aaa gct gta gct cgc ctg agg agc aca gga aga      402
 Arg Lys Leu Ala Arg Lys Ala Val Ala Arg Leu Arg Ser Thr Gly Arg
      85                  90                  95

 aag aag aag cgc tgc agg ttg cct ggt gtg gac tct gtc tta aaa ggc      450
 Lys Lys Lys Arg Cys Arg Leu Pro Gly Val Asp Ser Val Leu Lys Gly
 100                 105                 110                 115

 ctc ccc act gaa gaa aaa gat gaa aat gat gaa aac tca tta agc agt      498
 Leu Pro Thr Glu Glu Lys Asp Glu Asn Asp Glu Asn Ser Leu Ser Ser
                 120                 125                 130

 tcc tct gac tgt agt gaa aac aag gat gaa gaa ata agt gaa gaa agt      546
 Ser Ser Asp Cys Ser Glu Asn Lys Asp Glu Glu Ile Ser Glu Glu Ser
             135                 140                 145

 gat att gaa gaa aag act gaa gtg aaa gaa gaa cca gag ctt caa aca      594
 Asp Ile Glu Glu Lys Thr Glu Val Lys Glu Glu Pro Glu Leu Gln Thr
         150                 155                 160

 aga agg gaa atg gaa gaa aga aca ata act ata gaa atc cct gaa gtt      642
 Arg Arg Glu Met Glu Glu Arg Thr Ile Thr Ile Glu Ile Pro Glu Val
     165                 170                 175

 ctg aag aag cag ctg gag gat gat tgt tac tac att aac agg agg aaa      690
 Leu Lys Lys Gln Leu Glu Asp Asp Cys Tyr Tyr Ile Asn Arg Arg Lys
 180                 185                 190                 195

 cgg tta gtg aaa ctt cca tgc cag acc aac atc ata acg att ttg gaa      738
 Arg Leu Val Lys Leu Pro Cys Gln Thr Asn Ile Ile Thr Ile Leu Glu
                 200                 205                 210

 tcc tat gtg aag cat ttt gct atc aat gca gcc ttt tca gcc aat gag      786
 Ser Tyr Val Lys His Phe Ala Ile Asn Ala Ala Phe Ser Ala Asn Glu
             215                 220                 225

 agg cct cgt cac cat cac gtt atg cca cat gcc aac atg aac gtg cat      834
 Arg Pro Arg His His His Val Met Pro His Ala Asn Met Asn Val His
         230                 235                 240

 tat atc cca gca gaa aag aat gtt gac ctt tgt aag gag atg gtg gat      882
 Tyr Ile Pro Ala Glu Lys Asn Val Asp Leu Cys Lys Glu Met Val Asp
     245                 250                 255

 gga tta aga ata acc ttt gat tac act ctc ccg ttg gtt tta ctc tat      930
 Gly Leu Arg Ile Thr Phe Asp Tyr Thr Leu Pro Leu Val Leu Leu Tyr
 260                 265                 270                 275

 ccc tat gaa caa gct cag tat aaa aag gtg act gca tct aag gtt ttt      978
 Pro Tyr Glu Gln Ala Gln Tyr Lys Lys Val Thr Ala Ser Lys Val Phe
                 280                 285                 290

 ctt gca att aag gaa agt gcc aca aat act aat agg agc cag gag aag     1026
 Leu Ala Ile Lys Glu Ser Ala Thr Asn Thr Asn Arg Ser Gln Glu Lys
             295                 300                 305

 ctc tct ccc agc tta cgt ttg ttg aat cca tcc agg ccg cag tct aca     1074
 Leu Ser Pro Ser Leu Arg Leu Leu Asn Pro Ser Arg Pro Gln Ser Thr
         310                 315                 320

 gag agt cag tcg acc agc ggt gaa cca gcc acc cct aaa agg cgc aaa     1122
 Glu Ser Gln Ser Thr Ser Gly Glu Pro Ala Thr Pro Lys Arg Arg Lys
     325                 330                 335

 gcc gag ccg caa gca gtg cag tct ctg agg cgg tcc tcg ccc cac acc     1170
 Ala Glu Pro Gln Ala Val Gln Ser Leu Arg Arg Ser Ser Pro His Thr
 340                 345                 350                 355

 gcc aac tgt gac agg ctt tct aag agc agc acc tca cct cag ccc aag     1218
 Ala Asn Cys Asp Arg Leu Ser Lys Ser Ser Thr Ser Pro Gln Pro Lys
                 360                 365                 370

 cgc tgg cag cag gac atg tcc acc agt gtg ccc aag ctg ttc ctg cac     1266
 Arg Trp Gln Gln Asp Met Ser Thr Ser Val Pro Lys Leu Phe Leu His
             375                 380                 385

 ctg gaa aag aag aca cct gtg cat agc aga tca tct tca cct act ctg     1314
 Leu Glu Lys Lys Thr Pro Val His Ser Arg Ser Ser Ser Pro Thr Leu
         390                 395                 400

 act cct agc cag gaa ggg agt cct gtg ttt gct ggc ttt gaa ggg aga     1362
 Thr Pro Ser Gln Glu Gly Ser Pro Val Phe Ala Gly Phe Glu Gly Arg
     405                 410                 415

 aga act aat gaa ata aat gag gtc ctc tcc tgg aag ctc gta cct gac     1410
 Arg Thr Asn Glu Ile Asn Glu Val Leu Ser Trp Lys Leu Val Pro Asp
 420                 425                 430                 435

 aat tac cca cca ggt gac cag cca cct cca ccc tct tac att tac ggg     1458
 Asn Tyr Pro Pro Gly Asp Gln Pro Pro Pro Pro Ser Tyr Ile Tyr Gly
                 440                 445                 450

 gcg caa cat ttg ctg cga ttg ttt gtc aaa ctt cca gaa att ctt gga     1506
 Ala Gln His Leu Leu Arg Leu Phe Val Lys Leu Pro Glu Ile Leu Gly
             455                 460                 465

 aaa atg tcc ttt act gag aag aat ctg aag gct tta ttg aag cac ttt     1554
 Lys Met Ser Phe Thr Glu Lys Asn Leu Lys Ala Leu Leu Lys His Phe
         470                 475                 480

 gat ctc ttt gtg agg ttt tta gca gaa tac cac gat gac ttc ttc cca     1602
 Asp Leu Phe Val Arg Phe Leu Ala Glu Tyr His Asp Asp Phe Phe Pro
     485                 490                 495

 gag tca gct tac gtc gct gcc tct gag gtg cat tac agc acc agg aac     1650
 Glu Ser Ala Tyr Val Ala Ala Ser Glu Val His Tyr Ser Thr Arg Asn
 500                 505                 510                 515

 ccc cag gca gtc aat aag tgt tga                                     1674
 Pro Gln Ala Val Asn Lys Cys 
                 520





      <210> 158
      <211> 801
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(801)

      <400> 158
  atg gtc tcg cct ctc cct ccc ccc acc ccg tgc cgg gtg cgc ggc ctg      48
  Met Val Ser Pro Leu Pro Pro Pro Thr Pro Cys Arg Val Arg Gly Leu
    1               5                  10                  15

 gga gtc agc ggc ccg agc ggg aag cgc cgg gcg agc cca ctg agc tgc       96
 Gly Val Ser Gly Pro Ser Gly Lys Arg Arg Ala Ser Pro Leu Ser Cys
              20                  25                  30

 ggc gcc aag atg agt gga gag gag aac cca gcc agc aag ccc acg ccg      144
 Gly Ala Lys Met Ser Gly Glu Glu Asn Pro Ala Ser Lys Pro Thr Pro
          35                  40                  45

 gtg cag gac gta cag ggc gac ggg cgc tgg atg tcc ctg cac cat cgg      192
 Val Gln Asp Val Gln Gly Asp Gly Arg Trp Met Ser Leu His His Arg
      50                  55                  60

 ttc gtg gct gac agc aaa gat aag gaa ccc gaa gtc gtc ttc atc ggg      240
 Phe Val Ala Asp Ser Lys Asp Lys Glu Pro Glu Val Val Phe Ile Gly
  65                  70                  75                  80

 gac tcc ttg gtc cag ctc atg cac cag tgc gag atc tgg cgc gag ctc      288
 Asp Ser Leu Val Gln Leu Met His Gln Cys Glu Ile Trp Arg Glu Leu
                  85                  90                  95

 ttc tct cct ctg cat gca ctt aac ttt ggc att ggt ggt gac ggc aca      336
 Phe Ser Pro Leu His Ala Leu Asn Phe Gly Ile Gly Gly Asp Gly Thr
             100                 105                 110

 cag cat gta ctg tgg cgg ctg gag aat ggg gag ctg gaa cac atc cgg      384
 Gln His Val Leu Trp Arg Leu Glu Asn Gly Glu Leu Glu His Ile Arg
         115                 120                 125

 ccc aag att gtg gtg gtc tgg gtg ggc acc aac aac cac gga cac aca      432
 Pro Lys Ile Val Val Val Trp Val Gly Thr Asn Asn His Gly His Thr
     130                 135                 140

 gca gag cag gtg act ggt ggc atc aag gcc att gtg caa ctg gtg aat      480
 Ala Glu Gln Val Thr Gly Gly Ile Lys Ala Ile Val Gln Leu Val Asn
 145                 150                 155                 160

 gag cga cag ccc cag gcc cgg gtt gtg gtg ctg ggc ctg ctt ccg cga      528
 Glu Arg Gln Pro Gln Ala Arg Val Val Val Leu Gly Leu Leu Pro Arg
                 165                 170                 175

 ggc caa cat ccc aac cca ctt cgg gag aag aac cga cag gtg aac gag      576
 Gly Gln His Pro Asn Pro Leu Arg Glu Lys Asn Arg Gln Val Asn Glu
             180                 185                 190

 ctg gta cgg gcg gca ctg gct ggc cac cct cgg gcc cac ttc cta gat      624
 Leu Val Arg Ala Ala Leu Ala Gly His Pro Arg Ala His Phe Leu Asp
         195                 200                 205

 gcc gac cct ggc ttt gtg cac tca gat ggc acc atc agc cat cat gac      672
 Ala Asp Pro Gly Phe Val His Ser Asp Gly Thr Ile Ser His His Asp
     210                 215                 220

 atg tat gat tac ctg cat ctg agc cgc ctg ggc tac aca cct gtt tgc      720
 Met Tyr Asp Tyr Leu His Leu Ser Arg Leu Gly Tyr Thr Pro Val Cys
 225                 230                 235                 240

 cgg gct ctg cac tcc ctg ctt ctg cgt ctg ctg gcc caa gac cag ggc      768
 Arg Ala Leu His Ser Leu Leu Leu Arg Leu Leu Ala Gln Asp Gln Gly
                 245                 250                 255

 caa ggt gct ccc ctg ctg gag ccc gca ccc taa                          801
 Gln Gly Ala Pro Leu Leu Glu Pro Ala Pro 
             260                 265





      <210> 159
      <211> 1104
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (16)..(1038)

      <400> 159
 ggcaacactg aagac atg ggc aag agc atc ccc caa tac ctg ggg caa ctg      51
                  Met Gly Lys Ser Ile Pro Gln Tyr Leu Gly Gln Leu
                    1               5                  10

 gac atc cgc aaa agc gta gtc agc ctg gcc aca ggc gcc ggg gcg atc       99
 Asp Ile Arg Lys Ser Val Val Ser Leu Ala Thr Gly Ala Gly Ala Ile
          15                  20                  25

 tac ctg ctc tac aag gcc atc aag gct ggc ata aaa tgc aaa cca ccc      147
 Tyr Leu Leu Tyr Lys Ala Ile Lys Ala Gly Ile Lys Cys Lys Pro Pro
      30                  35                  40

 ctc tgt agc aac tca ccc atc tgc atc gcc cgc ctg gca gtc gag cga      195
 Leu Cys Ser Asn Ser Pro Ile Cys Ile Ala Arg Leu Ala Val Glu Arg
  45                  50                  55                  60

 gag cgg cac ggg cgg gac tca ggt gag ctc cgg agg ctc ctc aac tct      243
 Glu Arg His Gly Arg Asp Ser Gly Glu Leu Arg Arg Leu Leu Asn Ser
                  65                  70                  75

 ttg gag tgc aaa cag gat gag tac gcc aag agc atg atc ctg cac agt      291
 Leu Glu Cys Lys Gln Asp Glu Tyr Ala Lys Ser Met Ile Leu His Ser
              80                  85                  90

 atc act cgc tgt gtg tac ttg ctg gag gct gag gcc tct gct tgt act      339
 Ile Thr Arg Cys Val Tyr Leu Leu Glu Ala Glu Ala Ser Ala Cys Thr
          95                 100                 105

 acg gat gac atc gtg ttg ctg ggc tac atg ctg gat gac aag gac aac      387
 Thr Asp Asp Ile Val Leu Leu Gly Tyr Met Leu Asp Asp Lys Asp Asn
     110                 115                 120

 agt gtc aaa acc caa gct ctg aat aca ctt aaa gct ttc tct ggc atc      435
 Ser Val Lys Thr Gln Ala Leu Asn Thr Leu Lys Ala Phe Ser Gly Ile
 125                 130                 135                 140

 aga aaa ttc agg ctc aaa atc cag gaa cac tcc atc aaa gta ctc gaa      483
 Arg Lys Phe Arg Leu Lys Ile Gln Glu His Ser Ile Lys Val Leu Glu
                 145                 150                 155

 ctg atc tcc acc atc tgg gac acg gaa ctg cac att gcg ggc ctc aga      531
 Leu Ile Ser Thr Ile Trp Asp Thr Glu Leu His Ile Ala Gly Leu Arg
             160                 165                 170

 ctc ctc aac aac ctt cca ctg ccc gac tat gtg cat cca cag ctg cga      579
 Leu Leu Asn Asn Leu Pro Leu Pro Asp Tyr Val His Pro Gln Leu Arg
         175                 180                 185

 cgg gtg atg cct gcc ttg atg gag atc ctg cag tca gac tac atc ctg      627
 Arg Val Met Pro Ala Leu Met Glu Ile Leu Gln Ser Asp Tyr Ile Leu
     190                 195                 200

 gca cag gtg caa gcc gta cga ctg ctg agc tac ctg gca cag aag aat      675
 Ala Gln Val Gln Ala Val Arg Leu Leu Ser Tyr Leu Ala Gln Lys Asn
 205                 210                 215                 220

 gac ctt ctc tat gac att ctc aac tgc cag gtt cac tcc aac ttc cta      723
 Asp Leu Leu Tyr Asp Ile Leu Asn Cys Gln Val His Ser Asn Phe Leu
                 225                 230                 235

 aac ctg ttc cag ccc aca cag tca ggg agt ctc ctg tat gag gta ctg      771
 Asn Leu Phe Gln Pro Thr Gln Ser Gly Ser Leu Leu Tyr Glu Val Leu
             240                 245                 250

 gtg ttt gct gag cgg ctg agt gag ggc cgg aac gca ccc cac tac cac      819
 Val Phe Ala Glu Arg Leu Ser Glu Gly Arg Asn Ala Pro His Tyr His
         255                 260                 265

 gtg gtg aaa tgg cat tac aac gaa cag tcc ctg cat gaa tcc ctc ttt      867
 Val Val Lys Trp His Tyr Asn Glu Gln Ser Leu His Glu Ser Leu Phe
     270                 275                 280

 ggg gaa gag tcc cga ctg gca gac cga cta ctt gcc ctg gtc atc cac      915
 Gly Glu Glu Ser Arg Leu Ala Asp Arg Leu Leu Ala Leu Val Ile His
 285                 290                 295                 300

 cct gag gaa gat gtt cag atc cag gcc tgc aag gtc att gtc agc ctg      963
 Pro Glu Glu Asp Val Gln Ile Gln Ala Cys Lys Val Ile Val Ser Leu
                 305                 310                 315

 cag tat ccc cag gac ttg aga gcc cgg ccc tcc tcc tgc cag ccc agt     1011
 Gln Tyr Pro Gln Asp Leu Arg Ala Arg Pro Ser Ser Cys Gln Pro Ser
             320                 325                 330

 cgt tcc tac ttt aaa aac acg gaa taa aatta aggagagcca ataaatgagt     1063
 Arg Ser Tyr Phe Lys Asn Thr Glu 
         335                 340

 ataggagaga aacttgaaaa aaaaaaaaaa aaaaaaaatt g                       1104




      <210> 160
      <211> 532
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (56)..(418)

      <400> 160
 atcacgagcg taagcaacag caacgctgag gaaacgggag ggaacggaca gcgta atg      58
                                                              Met
                                                                1

 acc atc acg agc ctc ctt aac aag tcc aag agt gag atg acc cca gag      106
 Thr Ile Thr Ser Leu Leu Asn Lys Ser Lys Ser Glu Met Thr Pro Glu
               5                  10                  15

 gag ctg cag aag cga gag gag gag gaa ttt aac acg ggt cca ctt tct      154
 Glu Leu Gln Lys Arg Glu Glu Glu Glu Phe Asn Thr Gly Pro Leu Ser
          20                  25                  30

 gtg ctc aca cag tca gtc aag aac aac acg caa gtg ctc atc aac tgt      202
 Val Leu Thr Gln Ser Val Lys Asn Asn Thr Gln Val Leu Ile Asn Cys
      35                  40                  45

 cgc cac aac acg aaa ctc ctg ggc cac gtg aag gcc ttc cac agg cac      250
 Arg His Asn Thr Lys Leu Leu Gly His Val Lys Ala Phe His Arg His
  50                  55                  60                  65

 tgc aac atg gtg ctg gag aac gtg aag gag acg tgg act gag gta ccc      298
 Cys Asn Met Val Leu Glu Asn Val Lys Glu Thr Trp Thr Glu Val Pro
                  70                  75                  80

 aag agc ggc aag ggc aag aag tcc aag cca gtc aac aaa gac tgc tat      346
 Lys Ser Gly Lys Gly Lys Lys Ser Lys Pro Val Asn Lys Asp Cys Tyr
              85                  90                  95

 atc tcc agg atg ttc ctg cac ggg gac ttg gtc atc gtg gtc ctg cgg      394
 Ile Ser Arg Met Phe Leu His Gly Asp Leu Val Ile Val Val Leu Arg
         100                 105                 110

 aac cca ctc atc gcc agc aag tag ggtccgcgtg tccagtctgt cagaactcgt     448
 Asn Pro Leu Ile Ala Ser Lys 
     115                 120

 tcgttggtgc tatggaggca tcgatcattg gtgttgggga taatacagtt ttgtgttttt    508

 ttttaggcaa aaaaaaaaaa aaag                                           532




      <210> 161
      <211> 2258
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (990)..(1481)

      <400> 161
 tctccccgcc cgccggcccc tccagcctcc tccaaggcgg cggaccaggc cgggccggag     60

 ttttcggggt tcagcccgcg agcgggagga ccggggaggc gagggaggag gaaggcgaga    120

 agggccagat cgcgggagag cccaatcacg gggcgagctg gacctggctg tgatcattta    180

 taatccttga ctcctccgct ccgccacttg tcaagatgac aggggtcatc cgtgaataac    240

 acttcacgct gatgaatggc tcttgccggc tttcggctct gatgaggggt ctgcccgccg    300

 ccgattgaaa acactaatga acttactgcg ccatttgaaa ttcacacgca ccaacaaaat    360

 ggggggtggg catttcaggt cagctgagtc acccgaggga ggtggcagtg caagacactg    420

 ccgggaagac ggattccgag gcagaagggt gtaattaagg atttccaccc ccggtaggcg    480

 gcccgtcctt tgcagagcct ctgaaaatga cccgcgcctt cctttccaca gtgttctttc    540

 gtccgagacc gaaaagcgca aatgaccttt ggacagggaa gggaggcagt aaacactcag    600

 acttccttac cagcccctgg tgggcactgc agcagaacaa ttgtctgccc cccaggttca    660

 agcacctagg cctccgcccc gcatcacctg gccaggggcg gaccccggga gtcctccgaa    720

 ggctccactc cccactttta ctactcttct ttcctctcca ttctcccctc agattagcgg    780

 ccggacactg tccctgcctc gattttgttt gctgtgggag ggaaaaaaaa agtttgctgc    840

 tcctcccaag acactggcca ctttctactc actgaagttc ccaccgcagc gctggctccc    900

 ggctccctag ctcccgcccc ctgtctgcag gaaagccctc ccccggagct tccgaaactg    960

 ctggaggttc cagagttttg tagctccga  atg ggc gac ctg agc cga acc gct    1013
                                  Met Gly Asp Leu Ser Arg Thr Ala
                                    1               5

 ctc tgg ctg ggt ggt cgg cgg gat cct tca ggc tcc ttt cgg gtc cgg     1061
 Leu Trp Leu Gly Gly Arg Arg Asp Pro Ser Gly Ser Phe Arg Val Arg
      10                  15                  20

 gac ggg gcg gcg gca gag gtg ggg cgt gcg tgc ttg ggg ctg ccg agt     1109
 Asp Gly Ala Ala Ala Glu Val Gly Arg Ala Cys Leu Gly Leu Pro Ser
  25                  30                  35                  40

 gag tgc ggc tcc ctg gtg cgc gcc cga gca tct ccc cgc cct ctc ctg     1157
 Glu Cys Gly Ser Leu Val Arg Ala Arg Ala Ser Pro Arg Pro Leu Leu
                  45                  50                  55

 gga cca gca gtc tgc ccg tgg agg gct agg agc ccg cga cca ggc ctg     1205
 Gly Pro Ala Val Cys Pro Trp Arg Ala Arg Ser Pro Arg Pro Gly Leu
              60                  65                  70

 ccc cgg ccg tcg cca acc tgt cct tgg aag cgt ggc gga gac tgg tgc     1253
 Pro Arg Pro Ser Pro Thr Cys Pro Trp Lys Arg Gly Gly Asp Trp Cys
          75                  80                  85

 gct ctc agc ctc gtc gcg cca gcc gcc tcg cgc cac cct cca ctt tca     1301
 Ala Leu Ser Leu Val Ala Pro Ala Ala Ser Arg His Pro Pro Leu Ser
      90                  95                 100

 gct tca gag cag agg att ccg ccg acc tcc acc tgt acc tgt act cgg     1349
 Ala Ser Glu Gln Arg Ile Pro Pro Thr Ser Thr Cys Thr Cys Thr Arg
 105                 110                 115                 120

 ccg tta gga aat cca ctt gca ttt tta act acc gtg cag aac cag aaa     1397
 Pro Leu Gly Asn Pro Leu Ala Phe Leu Thr Thr Val Gln Asn Gln Lys
                 125                 130                 135

 cag atc gag cac tgg gca gaa caa gga cga cgc ctc cta gga aag cct     1445
 Gln Ile Glu His Trp Ala Glu Gln Gly Arg Arg Leu Leu Gly Lys Pro
             140                 145                 150

 gaa cct tta tgt aag ttt atc caa agt tgg ggc tag aagt gaggagaatc     1495
 Glu Pro Leu Cys Lys Phe Ile Gln Ser Trp Gly 
         155                 160

 cctaaactcg aggtggtgtg cccagaccca cagcccgtgt tcccgaagtt gctaagtgcc   1555

 cgagcgcagc gcgttaagta gagaagtctt ggtagtaagc gaacccgacc cggctctcgg   1615

 gcgctagtga cggaaagcag cacgcatatc tttgcgggaa gaatctagag tcgccctggg   1675

 atagatgcat ctccttctgc cactgaattt cacacttgaa aaagataagg tcatgggggc   1735

 ggatgaatga tatccctcac tcatttagcc attcttatta ttatataaaa aaaaggcttg   1795

 tcaattatga aggtgtgtcc cagatattac atgaagatca tgcaaactac ttgaaatttg   1855

 aatccggaca tgatcgtaag gaaactcttt cataaagcac ttttgtggcc tagttcccac   1915

 acacacacaa aagtattagg tctttaaaac ttttccaagt agtaagtgag actccctctt   1975

 actgtctacg aatacacaat aaagagatga gacactgccc caatcctaaa gaggccagaa   2035

 ctgaagtgct acattgtggg agttagggga tgcttctttt ttccagctct tttttctaga   2095

 atcctcatta cagctaacgc tggtaataaa ggtaggaaaa caatagaact cataaaactt   2155

 agaaatggta ataaatcttg gctcctgtct ctagcccagt tccttcttac atgagattca   2215

 aagtttttca gtatgcaatg ctgaacgttc acactatggt tgc                     2258




      <210> 162
      <211> 1148
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1104)

      <400> 162
  atg ggg ttc tgg aac ctg cag gat cag tac ggt atc ccg gtc gac cca      48
  Met Gly Phe Trp Asn Leu Gln Asp Gln Tyr Gly Ile Pro Val Asp Pro
    1               5                  10                  15

 cgc gtc cgg caa ggc ggc ggc agg aga ggt tgt ggt gct agt ttc tct       96
 Arg Val Arg Gln Gly Gly Gly Arg Arg Gly Cys Gly Ala Ser Phe Ser
              20                  25                  30

 aag cca tcc agt gcc atc ctc gtc gct gca gcg aca cac gct ctc gcc      144
 Lys Pro Ser Ser Ala Ile Leu Val Ala Ala Ala Thr His Ala Leu Ala
          35                  40                  45

 gcc gcc atg act gag cag atg acc ctt cgt ggc acc ctc aag ggc cac      192
 Ala Ala Met Thr Glu Gln Met Thr Leu Arg Gly Thr Leu Lys Gly His
      50                  55                  60

 aac ggc tgg gta acc cag atc gct act acc ccg cag ttc ccg gac atg      240
 Asn Gly Trp Val Thr Gln Ile Ala Thr Thr Pro Gln Phe Pro Asp Met
  65                  70                  75                  80

 atc ctc tcc gcc tct cga gat aag acc atc atc atg tgg aaa ctg acc      288
 Ile Leu Ser Ala Ser Arg Asp Lys Thr Ile Ile Met Trp Lys Leu Thr
                  85                  90                  95

 agg gat gag acc aac tat gga att cca cag cgt gct ctg cgg ggt cac      336
 Arg Asp Glu Thr Asn Tyr Gly Ile Pro Gln Arg Ala Leu Arg Gly His
             100                 105                 110

 tcc cac ttt gtt agt gat gtg gtt atc tcc tca gat ggc cag ttt gcc      384
 Ser His Phe Val Ser Asp Val Val Ile Ser Ser Asp Gly Gln Phe Ala
         115                 120                 125

 ctc tca ggc tcc tgg gat gga acc ctg cgc ctc tgg gat ctc aca acg      432
 Leu Ser Gly Ser Trp Asp Gly Thr Leu Arg Leu Trp Asp Leu Thr Thr
     130                 135                 140

 ggc acc acc acg agg cga ttt gtg ggc cat acc aag gat gtg ctg agt      480
 Gly Thr Thr Thr Arg Arg Phe Val Gly His Thr Lys Asp Val Leu Ser
 145                 150                 155                 160

 gtg gcc ttc tcc tct gac aac cgg cag att gtc tct gga tct cga gat      528
 Val Ala Phe Ser Ser Asp Asn Arg Gln Ile Val Ser Gly Ser Arg Asp
                 165                 170                 175

 aaa acc atc aag cta tgg aat acc ctg ggt gtg tgc aaa tac act gtc      576
 Lys Thr Ile Lys Leu Trp Asn Thr Leu Gly Val Cys Lys Tyr Thr Val
             180                 185                 190

 cag gat gag agc cac tca gag tgg gtg tct tgt gtc cgc ttc tcg ccc      624
 Gln Asp Glu Ser His Ser Glu Trp Val Ser Cys Val Arg Phe Ser Pro
         195                 200                 205

 aac agc agc aac cct atc atc gtc tcc tgt ggc tgg gac aag ctg gtc      672
 Asn Ser Ser Asn Pro Ile Ile Val Ser Cys Gly Trp Asp Lys Leu Val
     210                 215                 220

 aag gta tgg aac ctg gct aac tgc aag ctg aag acc aac cac att ggc      720
 Lys Val Trp Asn Leu Ala Asn Cys Lys Leu Lys Thr Asn His Ile Gly
 225                 230                 235                 240

 cac aca ggc tat ctg aac acg gtg act gtc tct cca gat gga tcc ctc      768
 His Thr Gly Tyr Leu Asn Thr Val Thr Val Ser Pro Asp Gly Ser Leu
                 245                 250                 255

 tgt gct tct gga ggc aag gat ggc cag gcc atg tta tgg gat ctc aac      816
 Cys Ala Ser Gly Gly Lys Asp Gly Gln Ala Met Leu Trp Asp Leu Asn
             260                 265                 270

 gaa ggc aaa cac ctt tac acg cta gat ggt ggg gac atc atc aac gcc      864
 Glu Gly Lys His Leu Tyr Thr Leu Asp Gly Gly Asp Ile Ile Asn Ala
         275                 280                 285

 ctg tgc ttc agc cct aac cgc tac tgg ctg tgt gct gcc aca ggc ccc      912
 Leu Cys Phe Ser Pro Asn Arg Tyr Trp Leu Cys Ala Ala Thr Gly Pro
     290                 295                 300

 agc atc aag atc tgg gat tta gag gga aag atc att gta gat gaa ctg      960
 Ser Ile Lys Ile Trp Asp Leu Glu Gly Lys Ile Ile Val Asp Glu Leu
 305                 310                 315                 320

 aag caa gaa gtt atc agt acc agc agc aag gca gaa cca ccc cag tgc     1008
 Lys Gln Glu Val Ile Ser Thr Ser Ser Lys Ala Glu Pro Pro Gln Cys
                 325                 330                 335

 act tcc ctg gcc tgg tct gct gat ggc cag act ctg ttt gct ggc tac     1056
 Thr Ser Leu Ala Trp Ser Ala Asp Gly Gln Thr Leu Phe Ala Gly Tyr
             340                 345                 350

 acg gac aac ctg gtg cga gtg tgg cag gtg acc att ggc aca cgc tag     1104
 Thr Asp Asn Leu Val Arg Val Trp Gln Val Thr Ile Gly Thr Arg 
         355                 360                 365

 aagtttatgg cagagcttta caaataaaaa aaaaatggct tttc                    1148




      <210> 163
      <211> 2099
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1051)..(2055)

      <400> 163
 atgtgcgaac tcgatatttt acacgactct ctttaccaat tctgccccga attacactta     60

 aaacgactca acagcttaac gttggcttgc cacgccttac ttgactgtaa aactctcact    120

 cttaccgaac ttggccgtaa cctgccaacc aaagcgagaa caaaacataa catcaaacga    180

 atcgaccgat tgttaggtaa tcgtcacctc cacaaagagc gactcgctgt ataccgttgg    240

 catgctagct ttatctgttc gggcaatacg atgcccattg tacttgttga ctggtctgat    300

 atccgtgagc aaaaacggct tatggtattg cgagcttcag tcgcactaca cggtcgttct    360

 gttactcttt atgagaaagc gttcccgctt tcagagcaat gttcaaagaa agctcatgac    420

 caatttctag ccgaccttgc gagcattcta ccgagtaaca ccacaccgct cattgtcagt    480

 gatgctggct ttaaagtgcc atggtataaa tccgttgaga agctgggttg gtactggtta    540

 agtcgagtaa gaggaaaagt acaatatgca gacctaggag cggaaaactg gaaacctatc    600

 agcaacttac atgatatgtc atctagtcac tcaaagactt taggctataa gaggctgact    660

 aaaagcaatc caatctcatg ccaaattcta ttgtataaat ctcgctctaa aggccgaaaa    720

 aatcagcgct cgacacggac tcattgtcac cacccgtcac ctaaaatcta ctcagcgtcg    780

 gcaaaggagc catggattct agcaactaac ttacctgttg aaattcgaac acccaaacaa    840

 cttgttaata tctattcgaa gcgaatgcag attgaagaaa ccttccgaga cttgaaaagt    900

 cctgcctacg gactaggcct acgccatagc cgaacgagca gctcagagcg ttttgatatc    960

 atgctgctaa tcgccctgat gcttcaacta acatgttggc ttgcgggcgt tcatgctcag   1020

 aaacaagcga cacacgctct cgccgccgcc     atg act gag cag atg acc ctt    1071
                                      Met Thr Glu Gln Met Thr Leu
                                        1               5

 cgt ggc acc ctc aag ggc cac aac ggc tgg gta acc cag atc gct act     1119
 Arg Gly Thr Leu Lys Gly His Asn Gly Trp Val Thr Gln Ile Ala Thr
          10                  15                  20

 acc ccg cag ttc ccg gac atg atc ctc tcc gcc tct cga gat aag acc     1167
 Thr Pro Gln Phe Pro Asp Met Ile Leu Ser Ala Ser Arg Asp Lys Thr
      25                  30                  35

 atc atc atg tgg aaa ctg acc agg gat gag acc aac tat gga att cca     1215
 Ile Ile Met Trp Lys Leu Thr Arg Asp Glu Thr Asn Tyr Gly Ile Pro
  40                  45                  50                  55

 cag cgt gct ctg cgg ggt cac tcc cac ttt gtt agt gat gtg gtt atc     1263
 Gln Arg Ala Leu Arg Gly His Ser His Phe Val Ser Asp Val Val Ile
                  60                  65                  70

 tcc tca gat ggc cag ttt gcc ctc tca ggc tcc tgg gat gga acc ctg     1311
 Ser Ser Asp Gly Gln Phe Ala Leu Ser Gly Ser Trp Asp Gly Thr Leu
              75                  80                  85

 cgc ctc tgg gat ctc aca acg caa gta gct gct cac tta gct ctg ggg     1359
 Arg Leu Trp Asp Leu Thr Thr Gln Val Ala Ala His Leu Ala Leu Gly
          90                  95                 100

 cct tgg gaa gaa tct ggg cag aag ggc acc acc acg agg cga ttt gtg     1407
 Pro Trp Glu Glu Ser Gly Gln Lys Gly Thr Thr Thr Arg Arg Phe Val
     105                 110                 115

 ggc cat acc aag gat gtg ctg agt gtg gcc ttc tcc tct gac aac cgg     1455
 Gly His Thr Lys Asp Val Leu Ser Val Ala Phe Ser Ser Asp Asn Arg
 120                 125                 130                 135

 cag att gtc tct gga tct cga gat aaa acc atc aag cta tgg aat acc     1503
 Gln Ile Val Ser Gly Ser Arg Asp Lys Thr Ile Lys Leu Trp Asn Thr
                 140                 145                 150

 ctg ggt gtg tgc aaa tac act gtc cag gat gag agc cac tca gag tgg     1551
 Leu Gly Val Cys Lys Tyr Thr Val Gln Asp Glu Ser His Ser Glu Trp
             155                 160                 165

 gtg tct tgt gtc cgc ttc tcg ccc aac agc agc aac cct atc atc gtc     1599
 Val Ser Cys Val Arg Phe Ser Pro Asn Ser Ser Asn Pro Ile Ile Val
         170                 175                 180

 tcc tgt ggc tgg gac aag ctg gtc aag gta tgg aac ctg gct aac tgc     1647
 Ser Cys Gly Trp Asp Lys Leu Val Lys Val Trp Asn Leu Ala Asn Cys
     185                 190                 195

 aag ctg aag acc aac cac att ggc cac aca ggc tat ctg aac acg gtg     1695
 Lys Leu Lys Thr Asn His Ile Gly His Thr Gly Tyr Leu Asn Thr Val
 200                 205                 210                 215

 act gtc tct cca gat gga tcc ctc tgt gct tct gga ggc aag gat ggc     1743
 Thr Val Ser Pro Asp Gly Ser Leu Cys Ala Ser Gly Gly Lys Asp Gly
                 220                 225                 230

 cag gcc atg tta tgg gat ctc aac gaa ggc aaa cac ctt tac acg cta     1791
 Gln Ala Met Leu Trp Asp Leu Asn Glu Gly Lys His Leu Tyr Thr Leu
             235                 240                 245

 gat ggt ggg gac atc atc aac gcc ctg tgc ttc agc cct aac cgc tac     1839
 Asp Gly Gly Asp Ile Ile Asn Ala Leu Cys Phe Ser Pro Asn Arg Tyr
         250                 255                 260

 tgg ctg tgt gct gcc aca ggc ccc agc atc aag atc tgg gat tta gag     1887
 Trp Leu Cys Ala Ala Thr Gly Pro Ser Ile Lys Ile Trp Asp Leu Glu
     265                 270                 275

 gga aag atc att gta gat gaa ctg aag caa gaa gtt atc agt acc agc     1935
 Gly Lys Ile Ile Val Asp Glu Leu Lys Gln Glu Val Ile Ser Thr Ser
 280                 285                 290                 295

 agc aag gca gaa cca ccc cag tgc act tcc ctg gcc tgg tct gct gat     1983
 Ser Lys Ala Glu Pro Pro Gln Cys Thr Ser Leu Ala Trp Ser Ala Asp
                 300                 305                 310

 ggc cag act ctg ttt gct ggc tac acg gac aac ctg gtg cga gtg tgg     2031
 Gly Gln Thr Leu Phe Ala Gly Tyr Thr Asp Asn Leu Val Arg Val Trp
             315                 320                 325

 cag gtg acc att ggc aca cgc tag aagtttatgg cagagcttta caaataaaaa    2085
 Gln Val Thr Ile Gly Thr Arg 
         330

 aaaaatggct tttc                                                     2099




      <210> 164
      <211> 2975
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (218)..(2773)

      <400> 164
 cccacgcgtc cgctgtggtg agagacggac cgagaccgga gatgttttca agcccggctc     60

 cggcggcttt acaggcggct gcagcggcga cgaagacaac gacagcgacg gctacgccga    120

 agcactcgtt ccgggggtga agcctcctgc gccggccttg cctcggatcc aggatgagaa    180

 gactgataaa agaagaagct agctgaacag ctgtaaa atg ccc aaa tct ggg ttc     235
                                          Met Pro Lys Ser Gly Phe
                                            1               5

 aca aaa cca att cag agt gaa aat tct gac agt gac agc aat atg gta      283
 Thr Lys Pro Ile Gln Ser Glu Asn Ser Asp Ser Asp Ser Asn Met Val
              10                  15                  20

 gag aaa cca tat gga aga aag agt aaa gac aag att gca tcc tac agc      331
 Glu Lys Pro Tyr Gly Arg Lys Ser Lys Asp Lys Ile Ala Ser Tyr Ser
          25                  30                  35

 aaa act cca aaa att gaa cga agt gat gtg agc aag gag atg aaa gag      379
 Lys Thr Pro Lys Ile Glu Arg Ser Asp Val Ser Lys Glu Met Lys Glu
      40                  45                  50

 aaa tca tcc atg aaa cgt aaa ctt cct ttt act att agc cca tca aga      427
 Lys Ser Ser Met Lys Arg Lys Leu Pro Phe Thr Ile Ser Pro Ser Arg
  55                  60                  65                  70

 aat gaa gaa cga gat tca gac aca gag aaa gaa ggt cca gaa aag aag      475
 Asn Glu Glu Arg Asp Ser Asp Thr Glu Lys Glu Gly Pro Glu Lys Lys
                  75                  80                  85

 aag aca aaa aag gaa gct gga aat aag aaa tcc aca cca gtt agc att      523
 Lys Thr Lys Lys Glu Ala Gly Asn Lys Lys Ser Thr Pro Val Ser Ile
              90                  95                 100

 ctt ttt ggt tat cca ctc tct gag cga aaa cag atg gca ctt ctt atg      571
 Leu Phe Gly Tyr Pro Leu Ser Glu Arg Lys Gln Met Ala Leu Leu Met
         105                 110                 115

 cag atg aca gca aga gac aac agt cca gat tcc aca cca aat cat cca      619
 Gln Met Thr Ala Arg Asp Asn Ser Pro Asp Ser Thr Pro Asn His Pro
     120                 125                 130

 tca caa aca acg cct gcc caa aag aaa act ccc agt tct tca tct cga      667
 Ser Gln Thr Thr Pro Ala Gln Lys Lys Thr Pro Ser Ser Ser Ser Arg
 135                 140                 145                 150

 cag aaa gat aaa gtt aat aaa aga aat gaa cgt ggt gaa act cct tta      715
 Gln Lys Asp Lys Val Asn Lys Arg Asn Glu Arg Gly Glu Thr Pro Leu
                 155                 160                 165

 cac atg gct gct att cga gga gat gtg aaa caa gtt aaa gaa tta ata      763
 His Met Ala Ala Ile Arg Gly Asp Val Lys Gln Val Lys Glu Leu Ile
             170                 175                 180

 agt tta ggg gca aat gtg aat gtg aaa gat ttt gca ggt tgg aca cca      811
 Ser Leu Gly Ala Asn Val Asn Val Lys Asp Phe Ala Gly Trp Thr Pro
         185                 190                 195

 ctg cat gaa gct tgc aat gtt gga tat tac gat gtt gct aag ata ctt      859
 Leu His Glu Ala Cys Asn Val Gly Tyr Tyr Asp Val Ala Lys Ile Leu
     200                 205                 210

 ata gca gct gga gca gat gtt aac aca caa gga tta gat gat gac act      907
 Ile Ala Ala Gly Ala Asp Val Asn Thr Gln Gly Leu Asp Asp Asp Thr
 215                 220                 225                 230

 cca ctc cat gat tct gct agt agt ggg cac aga gat ata gta aag ctg      955
 Pro Leu His Asp Ser Ala Ser Ser Gly His Arg Asp Ile Val Lys Leu
                 235                 240                 245

 tta ctt cgt cac ggt gga aat cca ttt caa gct aat aaa cat ggg gag     1003
 Leu Leu Arg His Gly Gly Asn Pro Phe Gln Ala Asn Lys His Gly Glu
             250                 255                 260

 cgt cca gtg gat gta gca gaa aca gag gag ttg gag ttg cta cta aaa     1051
 Arg Pro Val Asp Val Ala Glu Thr Glu Glu Leu Glu Leu Leu Leu Lys
         265                 270                 275

 aga gag gtg cct tta tct gat gat gat gaa agt tac aca gat tcc gaa     1099
 Arg Glu Val Pro Leu Ser Asp Asp Asp Glu Ser Tyr Thr Asp Ser Glu
     280                 285                 290

 gag gct caa tct gta aat cct tct agt gtt gat gaa aat att gac tct     1147
 Glu Ala Gln Ser Val Asn Pro Ser Ser Val Asp Glu Asn Ile Asp Ser
 295                 300                 305                 310

 gaa aca gag aaa gac tct ctc atc tgt gaa agt aaa cag ata ctt ccc     1195
 Glu Thr Glu Lys Asp Ser Leu Ile Cys Glu Ser Lys Gln Ile Leu Pro
                 315                 320                 325

 agt aaa aca cct ctt cca tct gcc ctt gat gag tat gag ttc aaa gat     1243
 Ser Lys Thr Pro Leu Pro Ser Ala Leu Asp Glu Tyr Glu Phe Lys Asp
             330                 335                 340

 gat gat gat gaa gaa att aat aag atg att gat gat agg cat att ctt     1291
 Asp Asp Asp Glu Glu Ile Asn Lys Met Ile Asp Asp Arg His Ile Leu
         345                 350                 355

 agg aaa gaa caa cga aaa gaa aat gaa cct gaa gca gaa aaa act cat     1339
 Arg Lys Glu Gln Arg Lys Glu Asn Glu Pro Glu Ala Glu Lys Thr His
     360                 365                 370

 tta ttt gca aaa cag gag aaa gcc ttc tat cct aaa tca ttt aaa agt     1387
 Leu Phe Ala Lys Gln Glu Lys Ala Phe Tyr Pro Lys Ser Phe Lys Ser
 375                 380                 385                 390

 aaa aaa caa aag cca tct agg gtc tta tat tca agt act gaa agt tct     1435
 Lys Lys Gln Lys Pro Ser Arg Val Leu Tyr Ser Ser Thr Glu Ser Ser
                 395                 400                 405

 gat gaa gaa gct ctt cag aat aaa aag att tct act tca tgt tcc gtc     1483
 Asp Glu Glu Ala Leu Gln Asn Lys Lys Ile Ser Thr Ser Cys Ser Val
             410                 415                 420

 atc cct gaa aca tca aat tct gat atg caa acc aaa aag gaa tat gta     1531
 Ile Pro Glu Thr Ser Asn Ser Asp Met Gln Thr Lys Lys Glu Tyr Val
         425                 430                 435

 gtt tca ggt gaa cac aaa cag aaa ggc aaa gtt aaa aga aaa ttg aaa     1579
 Val Ser Gly Glu His Lys Gln Lys Gly Lys Val Lys Arg Lys Leu Lys
     440                 445                 450

 aat cag aat aaa aat aaa gag aac caa gag cta aag caa gaa aag gaa     1627
 Asn Gln Asn Lys Asn Lys Glu Asn Gln Glu Leu Lys Gln Glu Lys Glu
 455                 460                 465                 470

 gga aaa gaa aat aca aga ata aca aac ttg aca gta aat act gga cta     1675
 Gly Lys Glu Asn Thr Arg Ile Thr Asn Leu Thr Val Asn Thr Gly Leu
                 475                 480                 485

 gat tgt tca gaa aag acc aga gag gag ggg aac ttt agg aaa tct ttt     1723
 Asp Cys Ser Glu Lys Thr Arg Glu Glu Gly Asn Phe Arg Lys Ser Phe
             490                 495                 500

 agc cca aaa gat gat act tca tta cat tta ttt cat att tcc act ggt     1771
 Ser Pro Lys Asp Asp Thr Ser Leu His Leu Phe His Ile Ser Thr Gly
         505                 510                 515

 aaa tct ccc aaa cat tct tgt gga tta agt gaa aaa cag tca aca cca     1819
 Lys Ser Pro Lys His Ser Cys Gly Leu Ser Glu Lys Gln Ser Thr Pro
     520                 525                 530

 cta aaa caa gaa cat act aaa aca tgt tta tca cca gga agt tct gaa     1867
 Leu Lys Gln Glu His Thr Lys Thr Cys Leu Ser Pro Gly Ser Ser Glu
 535                 540                 545                 550

 atg tca tta cag cct gat ctt gtt cgg tat gat aat aca gaa tct gaa     1915
 Met Ser Leu Gln Pro Asp Leu Val Arg Tyr Asp Asn Thr Glu Ser Glu
                 555                 560                 565

 ttc ttg cca gaa agt tca agt gta aaa tct tgt aag cat aag gaa aaa     1963
 Phe Leu Pro Glu Ser Ser Ser Val Lys Ser Cys Lys His Lys Glu Lys
             570                 575                 580

 agc aaa cat cag aaa gat ttc cac tta gaa ttt ggt gaa aaa tca aat     2011
 Ser Lys His Gln Lys Asp Phe His Leu Glu Phe Gly Glu Lys Ser Asn
         585                 590                 595

 gcc aaa ata aag gat gaa gat cat agt cca aca ttt gaa aat tca gat     2059
 Ala Lys Ile Lys Asp Glu Asp His Ser Pro Thr Phe Glu Asn Ser Asp
     600                 605                 610

 tgc aca ctg aaa aaa atg gat aaa gaa ggt aaa aca tta aaa aaa cat     2107
 Cys Thr Leu Lys Lys Met Asp Lys Glu Gly Lys Thr Leu Lys Lys His
 615                 620                 625                 630

 aaa ttg aag cat aaa gag agg gaa aaa gaa aag cat aaa aaa gaa att     2155
 Lys Leu Lys His Lys Glu Arg Glu Lys Glu Lys His Lys Lys Glu Ile
                 635                 640                 645

 gaa ggt gaa aag gaa aaa tac aaa act aag gat agt gcc aaa gaa ctg     2203
 Glu Gly Glu Lys Glu Lys Tyr Lys Thr Lys Asp Ser Ala Lys Glu Leu
             650                 655                 660

 cag agg agt gtg gaa ttt gat aga gaa ttt tgg aaa gag aat ttt ttt     2251
 Gln Arg Ser Val Glu Phe Asp Arg Glu Phe Trp Lys Glu Asn Phe Phe
         665                 670                 675

 aaa agt gat gaa act gaa gat ctc ttt tta aat atg gaa cat gaa tcc     2299
 Lys Ser Asp Glu Thr Glu Asp Leu Phe Leu Asn Met Glu His Glu Ser
     680                 685                 690

 tta aca tta gaa aaa aaa tca aaa ttg gaa aaa aac atc aaa gat gat     2347
 Leu Thr Leu Glu Lys Lys Ser Lys Leu Glu Lys Asn Ile Lys Asp Asp
 695                 700                 705                 710

 aaa tca acc aag gaa aag cat gtg tca aaa gag agg aac ttt aaa gag     2395
 Lys Ser Thr Lys Glu Lys His Val Ser Lys Glu Arg Asn Phe Lys Glu
                 715                 720                 725

 gaa cga gac aag att aaa aag gaa agc gag aaa tct ttt agg gag gaa     2443
 Glu Arg Asp Lys Ile Lys Lys Glu Ser Glu Lys Ser Phe Arg Glu Glu
             730                 735                 740

 aaa ata aaa gat cta aaa gaa gag aga gaa aac ata ccc aca gat aaa     2491
 Lys Ile Lys Asp Leu Lys Glu Glu Arg Glu Asn Ile Pro Thr Asp Lys
         745                 750                 755

 gac tca gaa ttt act tct ttg ggt atg agt gcc att gag gaa tct ata     2539
 Asp Ser Glu Phe Thr Ser Leu Gly Met Ser Ala Ile Glu Glu Ser Ile
     760                 765                 770

 ggg ctt cat tta gtg gaa aag gaa ata gac att gaa aaa caa gaa aag     2587
 Gly Leu His Leu Val Glu Lys Glu Ile Asp Ile Glu Lys Gln Glu Lys
 775                 780                 785                 790

 cat ata aag gaa agt aaa gaa aaa cct gag aag cga tct caa att aaa     2635
 His Ile Lys Glu Ser Lys Glu Lys Pro Glu Lys Arg Ser Gln Ile Lys
                 795                 800                 805

 gaa aag gac att gag aag atg gaa aga aaa acc ttt gaa aaa aaa aag     2683
 Glu Lys Asp Ile Glu Lys Met Glu Arg Lys Thr Phe Glu Lys Lys Lys
             810                 815                 820

 aag ata aaa cat gag cat aag tca gaa aaa gac aaa tta gat ctt agt     2731
 Lys Ile Lys His Glu His Lys Ser Glu Lys Asp Lys Leu Asp Leu Ser
         825                 830                 835

 gaa tgt gtt gat aaa aaa aaa aaa aag ggc cgc ccc ctt taa aggatcc     2780
 Glu Cys Val Asp Lys Lys Lys Lys Lys Gly Arg Pro Leu 
     840                 845                 850

 aatcttacgt acccgtgctt gcaacgacat agcttttttt tagggccccc aaaattcaat   2840

 cccccgcccc tctttttaca acacctgaac tgaaaaaacc ctcccgtgcc ccaccttatt   2900

 cccctttaaa aaaagatacc aaaagtgggg gggacaatgg ggaaaatctt ttcccctcgg   2960

 aaaatatttt ccccg                                                    2975




      <210> 165
      <211> 1365
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1365)

      <400> 165
  atg ttc caa gca ggg aac agg aga aaa aaa gaa agg cac aaa tca aca      48
  Met Phe Gln Ala Gly Asn Arg Arg Lys Lys Glu Arg His Lys Ser Thr
    1               5                  10                  15

 agc aag cag aga aga aag aaa agg aaa aat cca agt ctt acc aat gca       96
 Ser Lys Gln Arg Arg Lys Lys Arg Lys Asn Pro Ser Leu Thr Asn Ala
              20                  25                  30

 gaa ttt gag gag atg gtc cag att gtt ctg cag aag tcc ctt cag gag      144
 Glu Phe Glu Glu Met Val Gln Ile Val Leu Gln Lys Ser Leu Gln Glu
          35                  40                  45

 tgc ttg ggg atg gga tct ggc ctt gat ttt gca gag act tct tgt gcc      192
 Cys Leu Gly Met Gly Ser Gly Leu Asp Phe Ala Glu Thr Ser Cys Ala
      50                  55                  60

 cag ccc gta gta tct acc caa tca gac aag gag cca gga att act gct      240
 Gln Pro Val Val Ser Thr Gln Ser Asp Lys Glu Pro Gly Ile Thr Ala
  65                  70                  75                  80

 tct gct act gat act gat aat gct aat gga gag gag gta cca cat act      288
 Ser Ala Thr Asp Thr Asp Asn Ala Asn Gly Glu Glu Val Pro His Thr
                  85                  90                  95

 caa gag att tca gtg tct tgg gaa ggt gaa gct gcc cct gag ata agg      336
 Gln Glu Ile Ser Val Ser Trp Glu Gly Glu Ala Ala Pro Glu Ile Arg
             100                 105                 110

 aca tct aag tta ggc cag cca gat cct gca ccc tct aag aag aaa tcc      384
 Thr Ser Lys Leu Gly Gln Pro Asp Pro Ala Pro Ser Lys Lys Lys Ser
         115                 120                 125

 aat aga ctc acc tta agc aaa aga aag aag gaa gct caa gat gag aag      432
 Asn Arg Leu Thr Leu Ser Lys Arg Lys Lys Glu Ala Gln Asp Glu Lys
     130                 135                 140

 gtg gag aaa act caa ggt gga cat gag cac aga cag gaa gac cga cta      480
 Val Glu Lys Thr Gln Gly Gly His Glu His Arg Gln Glu Asp Arg Leu
 145                 150                 155                 160

 aag aaa aca gtt cag gat cat tct cag atc agg gac cag caa aaa gga      528
 Lys Lys Thr Val Gln Asp His Ser Gln Ile Arg Asp Gln Gln Lys Gly
                 165                 170                 175

 gag ata agt ggt ttt ggt caa tgt ctg gtc tgg gtc cag tgt tcc ttc      576
 Glu Ile Ser Gly Phe Gly Gln Cys Leu Val Trp Val Gln Cys Ser Phe
             180                 185                 190

 cca aac tgt ggg aaa tgg agg cgg ctg tgt ggg aac att gac ccc tca      624
 Pro Asn Cys Gly Lys Trp Arg Arg Leu Cys Gly Asn Ile Asp Pro Ser
         195                 200                 205

 gtt ctc cca gat aat tgg tcc tgt gat cag aac aca gat gtg cag tat      672
 Val Leu Pro Asp Asn Trp Ser Cys Asp Gln Asn Thr Asp Val Gln Tyr
     210                 215                 220

 aat cgc tgt gat att cct gag gag acc tgg aca ggg ctt gag agt gat      720
 Asn Arg Cys Asp Ile Pro Glu Glu Thr Trp Thr Gly Leu Glu Ser Asp
 225                 230                 235                 240

 gtg gcc tat gcc tcc tac atc cca gga tcc atc atc tgg gcc aag caa      768
 Val Ala Tyr Ala Ser Tyr Ile Pro Gly Ser Ile Ile Trp Ala Lys Gln
                 245                 250                 255

 tac ggt tac ccc tgg tgg cca ggc atg ata gaa tct gat cct gac tta      816
 Tyr Gly Tyr Pro Trp Trp Pro Gly Met Ile Glu Ser Asp Pro Asp Leu
             260                 265                 270

 ggg gaa tat ttt ctt ttt act tcc cat ctt gat tcc ctg ccg tct aag      864
 Gly Glu Tyr Phe Leu Phe Thr Ser His Leu Asp Ser Leu Pro Ser Lys
         275                 280                 285

 tac cat gtg acg ttt ttt gga gaa aca gtt tct cgt gca tgg atc cca      912
 Tyr His Val Thr Phe Phe Gly Glu Thr Val Ser Arg Ala Trp Ile Pro
     290                 295                 300

 gtc aac atg cta aag aac ttc cag gag ctg tcc ctg gag cta tca gtc      960
 Val Asn Met Leu Lys Asn Phe Gln Glu Leu Ser Leu Glu Leu Ser Val
 305                 310                 315                 320

 atg aaa aag cgc aga aat gac tgc agc cag aaa ctg ggg gtg gcc ctg     1008
 Met Lys Lys Arg Arg Asn Asp Cys Ser Gln Lys Leu Gly Val Ala Leu
                 325                 330                 335

 atg atg gct caa gag gca gaa cag atc agc att cag gaa cgg gtt aac     1056
 Met Met Ala Gln Glu Ala Glu Gln Ile Ser Ile Gln Glu Arg Val Asn
             340                 345                 350

 ttg ttt ggt ttc tgg agc cga ttc aac gga tct aac agt aat ggg gaa     1104
 Leu Phe Gly Phe Trp Ser Arg Phe Asn Gly Ser Asn Ser Asn Gly Glu
         355                 360                 365

 aga aaa gac tta cag ctc tct ggt ttg aac agc cca gga tcc tgc tta     1152
 Arg Lys Asp Leu Gln Leu Ser Gly Leu Asn Ser Pro Gly Ser Cys Leu
     370                 375                 380

 gag aaa aag gag aaa gag gaa gag ttg gaa aag gag gaa gga gag aaa     1200
 Glu Lys Lys Glu Lys Glu Glu Glu Leu Glu Lys Glu Glu Gly Glu Lys
 385                 390                 395                 400

 aca gcc cta aga aaa aat tta aag ctc ccc aga gca agg cct tgg cag     1248
 Thr Ala Leu Arg Lys Asn Leu Lys Leu Pro Arg Ala Arg Pro Trp Gln
                 405                 410                 415

 cca gct ttt cag agg gaa aag aag tta gaa cag tgc caa aga acc tgg     1296
 Pro Ala Phe Gln Arg Glu Lys Lys Leu Glu Gln Cys Gln Arg Thr Trp
             420                 425                 430

 gcc tat cag cgt gta agg ggg cct gcc cct cat ctg cga aag aag agc     1344
 Ala Tyr Gln Arg Val Arg Gly Pro Ala Pro His Leu Arg Lys Lys Ser
         435                 440                 445

 cca gac acc ggg aac ccc tga                                         1365
 Pro Asp Thr Gly Asn Pro 
     450





      <210> 166
      <211> 1033
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (574)..(993)

      <400> 166
 ggccttgagt tattgggggt aattaacatg ggcataaccc cgccaccccc accttatctc     60

 cggatagagc agacctgcgc cttgatttat taaagaccaa gatccgaggc ctaaggaaac    120

 taacttatct acatcacttt cttcacatcc ccttgttatc taacctaagc tttcaggcac    180

 tggataagaa aatctggctg ctttcgggca aatccttttc tgaagctttt gtaaaacttc    240

 ccaaccttct aagaaggatc gcttctttct acaatttttc tcaccaccct taccgaaccc    300

 cggcagatgg gatgacctgc ctgcgtctgg gaggtaccca ctctgggtct tttctgcact    360

 gagggctgca cagatgtcag gatgacctgc ttgcggaaag gagcaaccca ctttgggtct    420

 cctgagagct gtactgtcgc tcagtaaagc tcctcttcac cttgttcatg ctccagttgt    480

 ccgtatacct cattgttcct gaatgcagga caagaacctg ggacctgtca aatggtgggg    540

 ctgaaagagc ggtaacacaa acagggctga aat atg tct ccc ttg ctc gcc gtg     594
                                      Met Ser Pro Leu Leu Ala Val
                                        1               5

 ttg cag gca aca aga agg aga gaa gag cgg cgg ccc ttc cag gag ccc      642
 Leu Gln Ala Thr Arg Arg Arg Glu Glu Arg Arg Pro Phe Gln Glu Pro
          10                  15                  20

 aga ctt agg ggc ttc ctg agc cag tgc tgt gac acc ccc ttt agg gct      690
 Arg Leu Arg Gly Phe Leu Ser Gln Cys Cys Asp Thr Pro Phe Arg Ala
      25                  30                  35

 ctg cgg ttt ctg gca tct cca agc ttc cag gtg cca ctg cat tcc cct      738
 Leu Arg Phe Leu Ala Ser Pro Ser Phe Gln Val Pro Leu His Ser Pro
  40                  45                  50                  55

 cgt cca gat gca ggt gcc cac agc aga agc cgc ttg cag tgc atc tca      786
 Arg Pro Asp Ala Gly Ala His Ser Arg Ser Arg Leu Gln Cys Ile Ser
                  60                  65                  70

 tcc agc tgc agg ctt gca tgg agc cag caa cta tgc tgg cac ctg gag      834
 Ser Ser Cys Arg Leu Ala Trp Ser Gln Gln Leu Cys Trp His Leu Glu
              75                  80                  85

 cta cct gct ctg cct ggc tgt gtg cag tgg cca ccg gtg tgc ctg gct      882
 Leu Pro Ala Leu Pro Gly Cys Val Gln Trp Pro Pro Val Cys Leu Ala
          90                  95                 100

 gtg tgc agt ggc tgg acc ccg cac tca ctc aca cac gcc ttg cca ctc      930
 Val Cys Ser Gly Trp Thr Pro His Ser Leu Thr His Ala Leu Pro Leu
     105                 110                 115

 tgt gct ttt ctt gcc ctt ggc agg ctt ggg atc cgc gct ggt agc aca      978
 Cys Ala Phe Leu Ala Leu Gly Arg Leu Gly Ile Arg Ala Gly Ser Thr
 120                 125                 130                 135

 agc ctg cca ggc tga gtgggcggaa tgagcccagc ggacctgagc aaaactcggg     1033
 Ser Leu Pro Gly 






      <210> 167
      <211> 1086
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (180)..(695)

      <400> 167
 aattcgcggc cgcgtcgaca cggctgcgag aagacgacag aagggggagc gcagagcggt     60

 ttggtcgttc gttgggcggt gctggttttt cgctcgtcga ctgcggctct tcctcgggca    120

 gcggaagcgg cgcggcggtc ggagaagtgg cctaaaactt cggcgttggg tgaaagaaa     179                                                                 
 atg gcc cga acc aag cag act gct cgt aag tcc acc ggt ggg aaa gcc      227
 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala
   1               5                  10                  15

 ccc cgc aaa cag ctg gcc acg aaa gcc gcc agg aaa agc gct ccc tct      275
 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ser
              20                  25                  30

 acc ggc ggg gtg aag aag cct cat cgc tac agg ccc ggg acc gtg gcg      323
 Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala
          35                  40                  45

 ctt cga gag att cgt cgt tat cag aag tcg acc gag ctg ctc atc cgg      371
 Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg
      50                  55                  60

 aag ctg ccc ttc cag agg ttg gtg agg gag atc gcg cag gat ttc aaa      419
 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys
  65                  70                  75                  80

 acc gac ctg agg ttt cag agc gca gcc atc ggt gcg ctg cag gag gct      467
 Thr Asp Leu Arg Phe Gln Ser Ala Ala Ile Gly Ala Leu Gln Glu Ala
                  85                  90                  95

 agc gaa gcg tac ctg gtg ggt ctg ttc gaa gat acc aac ctg tgt gcc      515
 Ser Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala
             100                 105                 110

 atc cac gct aag aga gtc acc atc atg ccc aaa gac atc cag ttg gct      563
 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala
         115                 120                 125

 cgc cgg atc ccg ggc acg aga gac gcc ttc cgt gac ggc agc tcc ctc      611
 Arg Arg Ile Pro Gly Thr Arg Asp Ala Phe Arg Asp Gly Ser Ser Leu
     130                 135                 140

 tgg cgt ctc gta cgc tac ctt ctg tac cac tac ttc ggt tta ctt tgt      659
 Trp Arg Leu Val Arg Tyr Leu Leu Tyr His Tyr Phe Gly Leu Leu Cys
 145                 150                 155                 160

 gac ttc tct tgt aag aac atc gta tat aat atg tag cata agtacttaag      709
 Asp Phe Ser Cys Lys Asn Ile Val Tyr Asn Met 
                 165                 170

 tcattccatc tttcacctca ggatgaatgc gaacagtgac tgtacacaga acctcagtga    769

 tgtgagcatc tgttgctcag gacgtgacaa gttgctaata tgcacgaagg gatgggtgat    829

 acattcttgc ttctcatgat gcatgtatac tgtatgtaaa tgacttgtag ggtagctatt    889

 aaggtactaa gagttgataa catgtgtaca gggtcctatg gcactataac tggttatgac    949

 ttgatccagg ctgtctaccg attggtcgct ggtacgctct gcaccatact tccctggcgg   1009

 ctcgcctggc tgggccttcc tcagcgggtg ccgggatccg aggtctacac ccgctgcggt   1069

 accttccccg tctccct                                                  1086




      <210> 168
      <211> 1176
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1176)

      <400> 168
  atg gac atg ctg gac ccg ggt ctg gat ccc gct gcc tcg gcc acc gct      48
  Met Asp Met Leu Asp Pro Gly Leu Asp Pro Ala Ala Ser Ala Thr Ala
    1               5                  10                  15

 gct gcc gcc gcc agc cac gac aag gga ccc gag gcg gag gag ggc gtc       96
 Ala Ala Ala Ala Ser His Asp Lys Gly Pro Glu Ala Glu Glu Gly Val
              20                  25                  30

 gag ctg cag gaa ggc ggg gac ggc cca gga gcg gag gag cag aca gcg      144
 Glu Leu Gln Glu Gly Gly Asp Gly Pro Gly Ala Glu Glu Gln Thr Ala
          35                  40                  45

 gtg gcc atc acc agc gtc cag cag gcg gcg ttc ggc gac cac aac atc      192
 Val Ala Ile Thr Ser Val Gln Gln Ala Ala Phe Gly Asp His Asn Ile
      50                  55                  60

 cag tac cag ttc cgc aca gag aca aat gga gga cag gtg aca tac cgc      240
 Gln Tyr Gln Phe Arg Thr Glu Thr Asn Gly Gly Gln Val Thr Tyr Arg
  65                  70                  75                  80

 gta gtc cag gtg act gat ggt cag ctg gac ggc cag ggc gac aca gct      288
 Val Val Gln Val Thr Asp Gly Gln Leu Asp Gly Gln Gly Asp Thr Ala
                  85                  90                  95

 ggc gcc gtc agc gtc gtg tcc acc gct gcc ttc gcg ggg ggg cag cag      336
 Gly Ala Val Ser Val Val Ser Thr Ala Ala Phe Ala Gly Gly Gln Gln
             100                 105                 110

 gct gtg acc cag gct gtg atc caa aat ccc ttc agc aat ggt ggc agt      384
 Ala Val Thr Gln Ala Val Ile Gln Asn Pro Phe Ser Asn Gly Gly Ser
         115                 120                 125

 ccg gcg gcc gag gct gtc agc ggg gag gca cga ttt gcc tat ttc cca      432
 Pro Ala Ala Glu Ala Val Ser Gly Glu Ala Arg Phe Ala Tyr Phe Pro
     130                 135                 140

 gcg tcc agt gtg gga gat act acg gct gtg tcc gta cag acc aca gac      480
 Ala Ser Ser Val Gly Asp Thr Thr Ala Val Ser Val Gln Thr Thr Asp
 145                 150                 155                 160

 cag agc ttg cag gct gga ggc cag ttc tac gtc atg atg acg ccc cag      528
 Gln Ser Leu Gln Ala Gly Gly Gln Phe Tyr Val Met Met Thr Pro Gln
                 165                 170                 175

 gat gtg ctt cag aca gga aca cag agg acg atc gcc ccc cgg aca cac      576
 Asp Val Leu Gln Thr Gly Thr Gln Arg Thr Ile Ala Pro Arg Thr His
             180                 185                 190

 cct tac tct cca aaa att gat gga acc aga aca ccc cga gat gag agg      624
 Pro Tyr Ser Pro Lys Ile Asp Gly Thr Arg Thr Pro Arg Asp Glu Arg
         195                 200                 205

 aga aga gcc cag cac aac gaa gat atg gca atg cag cag atg ata gga      672
 Arg Arg Ala Gln His Asn Glu Asp Met Ala Met Gln Gln Met Ile Gly
     210                 215                 220

 cag aca agg tct cag ctc tct gtg cgc gtt ctg gtg gga gag atg gga      720
 Gln Thr Arg Ser Gln Leu Ser Val Arg Val Leu Val Gly Glu Met Gly
 225                 230                 235                 240

 gtc aca cag ccg cat cag gca gtg cag gca gtc aca ggc agg aga gga      768
 Val Thr Gln Pro His Gln Ala Val Gln Ala Val Thr Gly Arg Arg Gly
                 245                 250                 255

 aag ctg ggg aag aag gtg gcg ggt gat ggc ggc atg gta gtg tgc tct      816
 Lys Leu Gly Lys Lys Val Ala Gly Asp Gly Gly Met Val Val Cys Ser
             260                 265                 270

 gaa ggg ctc ttc gag agt gaa att tcc agg gct gtc cca gtt cca atg      864
 Glu Gly Leu Phe Glu Ser Glu Ile Ser Arg Ala Val Pro Val Pro Met
         275                 280                 285

 gag cgg agg cgg agg gac aag atc aac aac tgg atc gtc cag ctt tcg      912
 Glu Arg Arg Arg Arg Asp Lys Ile Asn Asn Trp Ile Val Gln Leu Ser
     290                 295                 300

 aaa atc att cca gac tgt aac gca gac aac agc aag acg gga gcg agt      960
 Lys Ile Ile Pro Asp Cys Asn Ala Asp Asn Ser Lys Thr Gly Ala Ser
 305                 310                 315                 320

 aaa gga ggg atc ctg tcc aag gcc tgc gat tac atc cgg gag ttg cgc     1008
 Lys Gly Gly Ile Leu Ser Lys Ala Cys Asp Tyr Ile Arg Glu Leu Arg
                 325                 330                 335

 cag acc aac cag cgc atg cag gag acc ttc aaa gag gcc gag cgg ctg     1056
 Gln Thr Asn Gln Arg Met Gln Glu Thr Phe Lys Glu Ala Glu Arg Leu
             340                 345                 350

 cag atg gac aac gag ctc ctg agg cag cag atc gag gag ctg aag aat     1104
 Gln Met Asp Asn Glu Leu Leu Arg Gln Gln Ile Glu Glu Leu Lys Asn
         355                 360                 365

 gag aac gcc ctg ctt cga gcc cag ctg cag cag cac aac ctg gag atg     1152
 Glu Asn Ala Leu Leu Arg Ala Gln Leu Gln Gln His Asn Leu Glu Met
     370                 375                 380

 gtg ggc gag ggc acc cgg cag tga                                     1176
 Val Gly Glu Gly Thr Arg Gln 
 385                 390





      <210> 169
      <211> 2710
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (81)..(2660)

      <400> 169
 cgaggcctgg gtggaagttg gcgctgctgc cgccgccctg cagcccactc gctgcctcgg     60

 cagcgcgctg ctcttctaag    atg gct gcc gct acc ggt gcg gtg gca gcc     110
                          Met Ala Ala Ala Thr Gly Ala Val Ala Ala
                            1               5                  10

 tcg gcc gcc tcg ggt cag gcg gaa ggt aaa aag atc acc gat ctg cgg      158
 Ser Ala Ala Ser Gly Gln Ala Glu Gly Lys Lys Ile Thr Asp Leu Arg
                  15                  20                  25

 gtc atc gat ctg aag tcc gag ctg aag cgg cgg aac tta gac atc acc      206
 Val Ile Asp Leu Lys Ser Glu Leu Lys Arg Arg Asn Leu Asp Ile Thr
              30                  35                  40

 gga gtc aag acc gtg ctc atc tcc cga ctc aag cag gct att gaa gag      254
 Gly Val Lys Thr Val Leu Ile Ser Arg Leu Lys Gln Ala Ile Glu Glu
          45                  50                  55

 gaa gga ggc gat cca gat aat att gaa tta act gtt tca act gat act      302
 Glu Gly Gly Asp Pro Asp Asn Ile Glu Leu Thr Val Ser Thr Asp Thr
      60                  65                  70

 cca aac aag aaa cca act aaa ggc aaa ggt aaa aaa cat gaa gca gat      350
 Pro Asn Lys Lys Pro Thr Lys Gly Lys Gly Lys Lys His Glu Ala Asp
  75                  80                  85                  90

 gag ttg agt gga gat gct tct gtg gaa gat gat gct ttt atc aag gac      398
 Glu Leu Ser Gly Asp Ala Ser Val Glu Asp Asp Ala Phe Ile Lys Asp
                  95                 100                 105

 tgt gaa ttg gag aat caa gag gca cat gag caa gat gga aat gat gaa      446
 Cys Glu Leu Glu Asn Gln Glu Ala His Glu Gln Asp Gly Asn Asp Glu
             110                 115                 120

 cta aag gac tct gaa gaa ttt ggt gaa aat gaa gaa gaa aat gtg cat      494
 Leu Lys Asp Ser Glu Glu Phe Gly Glu Asn Glu Glu Glu Asn Val His
         125                 130                 135

 tcc aag gag tta ctc tct gca gaa gaa aac aag aga gct cat gaa tta      542
 Ser Lys Glu Leu Leu Ser Ala Glu Glu Asn Lys Arg Ala His Glu Leu
     140                 145                 150

 ata gag gca gaa gga ata gaa gat ata gaa aaa gag gac atc gaa agt      590
 Ile Glu Ala Glu Gly Ile Glu Asp Ile Glu Lys Glu Asp Ile Glu Ser
 155                 160                 165                 170

 cag gaa att gaa gct caa gaa ggt gaa gat gat acc ttt cta aca gcc      638
 Gln Glu Ile Glu Ala Gln Glu Gly Glu Asp Asp Thr Phe Leu Thr Ala
                 175                 180                 185

 caa gat ggt gag gaa gaa gaa aat gag aaa gat ata gca ggt tct ggt      686
 Gln Asp Gly Glu Glu Glu Glu Asn Glu Lys Asp Ile Ala Gly Ser Gly
             190                 195                 200

 gat ggt aca caa gaa gta tct aaa cct ctt cct tca gaa ggg agc cta      734
 Asp Gly Thr Gln Glu Val Ser Lys Pro Leu Pro Ser Glu Gly Ser Leu
         205                 210                 215

 gct gag gct gat cac aca gct cat gaa gag atg gaa gct cat acg act      782
 Ala Glu Ala Asp His Thr Ala His Glu Glu Met Glu Ala His Thr Thr
     220                 225                 230

 gtg aaa gaa gct gag gat gac aac atc tcg gtc aca atc cag gct gaa      830
 Val Lys Glu Ala Glu Asp Asp Asn Ile Ser Val Thr Ile Gln Ala Glu
 235                 240                 245                 250

 gat gcc atc act ctg gat ttt gat ggt gat gac ctc cta gaa aca ggt      878
 Asp Ala Ile Thr Leu Asp Phe Asp Gly Asp Asp Leu Leu Glu Thr Gly
                 255                 260                 265

 aaa aat gtg aaa att aca gat tct gaa gca agt aag cca aaa gat ggg      926
 Lys Asn Val Lys Ile Thr Asp Ser Glu Ala Ser Lys Pro Lys Asp Gly
             270                 275                 280

 cag gac gcc att gca cag agc ccg gag aag gaa agc aag gat tat gag      974
 Gln Asp Ala Ile Ala Gln Ser Pro Glu Lys Glu Ser Lys Asp Tyr Glu
         285                 290                 295

 atg aat gcg aac cat aaa gat ggt aag aag gaa gac tgc gtg aag ggt     1022
 Met Asn Ala Asn His Lys Asp Gly Lys Lys Glu Asp Cys Val Lys Gly
     300                 305                 310

 gac cct gtc gag aag gaa gcc aga gaa agt tct aag aaa gca gaa tct     1070
 Asp Pro Val Glu Lys Glu Ala Arg Glu Ser Ser Lys Lys Ala Glu Ser
 315                 320                 325                 330

 gga gac aaa gaa aag gat act ttg aag aaa ggg ccc tcg tct act ggg     1118
 Gly Asp Lys Glu Lys Asp Thr Leu Lys Lys Gly Pro Ser Ser Thr Gly
                 335                 340                 345

 gcc tct ggt caa gca aag agc tct tca aag gaa tct aaa gac agc aag     1166
 Ala Ser Gly Gln Ala Lys Ser Ser Ser Lys Glu Ser Lys Asp Ser Lys
             350                 355                 360

 aca tca tct aaa gat gac aaa gga agt aca agt agt act agt ggt agc     1214
 Thr Ser Ser Lys Asp Asp Lys Gly Ser Thr Ser Ser Thr Ser Gly Ser
         365                 370                 375

 agt gga agc tca act aaa aat atc tgg gtt agt gga ctt tca tct aat     1262
 Ser Gly Ser Ser Thr Lys Asn Ile Trp Val Ser Gly Leu Ser Ser Asn
     380                 385                 390

 acc aaa gct gct gat ttg aag aac ctc ttt ggc aaa tat gga aag gtt     1310
 Thr Lys Ala Ala Asp Leu Lys Asn Leu Phe Gly Lys Tyr Gly Lys Val
 395                 400                 405                 410

 ctg agt gca aaa gta gtt aca aat gct cga agt cct ggg gca aaa tgc     1358
 Leu Ser Ala Lys Val Val Thr Asn Ala Arg Ser Pro Gly Ala Lys Cys
                 415                 420                 425

 tat ggc att gta act atg tct tca agc aca gag gtg tcc agg tgt att     1406
 Tyr Gly Ile Val Thr Met Ser Ser Ser Thr Glu Val Ser Arg Cys Ile
             430                 435                 440

 gca cat ctt cat cgc act gag ctg cat gga cag ctg att tct gtt gaa     1454
 Ala His Leu His Arg Thr Glu Leu His Gly Gln Leu Ile Ser Val Glu
         445                 450                 455

 aaa gta aaa ggt gat ccc tct aag aaa gaa atg aag aaa gaa aat gat     1502
 Lys Val Lys Gly Asp Pro Ser Lys Lys Glu Met Lys Lys Glu Asn Asp
     460                 465                 470

 gaa aag agt agt tca aga agt tct gga gat aaa aaa aat acg agt gat     1550
 Glu Lys Ser Ser Ser Arg Ser Ser Gly Asp Lys Lys Asn Thr Ser Asp
 475                 480                 485                 490

 aga agt agc aag aca caa gcc tct gtc aaa aaa gaa gag aaa aga tcg     1598
 Arg Ser Ser Lys Thr Gln Ala Ser Val Lys Lys Glu Glu Lys Arg Ser
                 495                 500                 505

 tct gag aaa tct gaa aaa aaa gaa agc aag gat act aag aaa ata gaa     1646
 Ser Glu Lys Ser Glu Lys Lys Glu Ser Lys Asp Thr Lys Lys Ile Glu
             510                 515                 520

 ggt aaa gat gag aag aat gat aat gga gca agt ggc caa aca tca gaa     1694
 Gly Lys Asp Glu Lys Asn Asp Asn Gly Ala Ser Gly Gln Thr Ser Glu
         525                 530                 535

 tcg att aaa aaa agt gaa gaa aag aag cga ata agt tcc aag agt cca     1742
 Ser Ile Lys Lys Ser Glu Glu Lys Lys Arg Ile Ser Ser Lys Ser Pro
     540                 545                 550

 gga cat atg gta ata cta gac caa act aaa gga gat cat tgt aga cca     1790
 Gly His Met Val Ile Leu Asp Gln Thr Lys Gly Asp His Cys Arg Pro
 555                 560                 565                 570

 tca aga aga gga aga tat gag aaa att cat gga aga agt aag gaa aag     1838
 Ser Arg Arg Gly Arg Tyr Glu Lys Ile His Gly Arg Ser Lys Glu Lys
                 575                 580                 585

 gag aga gct agt cta gat aaa aaa aga gat aaa gac tac aga agg aaa     1886
 Glu Arg Ala Ser Leu Asp Lys Lys Arg Asp Lys Asp Tyr Arg Arg Lys
             590                 595                 600

 gag atc ttg cct ttt gaa aag atg aag gaa caa agg ttg aga gaa cat     1934
 Glu Ile Leu Pro Phe Glu Lys Met Lys Glu Gln Arg Leu Arg Glu His
         605                 610                 615

 tta gtt cgt ttt gaa agg ctg cga cga gca atg gaa ctt cga aga cga     1982
 Leu Val Arg Phe Glu Arg Leu Arg Arg Ala Met Glu Leu Arg Arg Arg
     620                 625                 630

 aga gag att gca gag aga gag cgt cga gag cga gaa cgc att aga ata     2030
 Arg Glu Ile Ala Glu Arg Glu Arg Arg Glu Arg Glu Arg Ile Arg Ile
 635                 640                 645                 650

 att cgt gaa cgg gaa gaa cgg gaa cgc tta cag aga gag aga gag cgc     2078
 Ile Arg Glu Arg Glu Glu Arg Glu Arg Leu Gln Arg Glu Arg Glu Arg
                 655                 660                 665

 cta gaa att gaa agg caa aaa cta gag aga gag aga atg gaa cgc gaa     2126
 Leu Glu Ile Glu Arg Gln Lys Leu Glu Arg Glu Arg Met Glu Arg Glu
             670                 675                 680

 cgc ttg gaa agg gaa cgc att cgt att gaa cag gaa cgt cgt aag gaa     2174
 Arg Leu Glu Arg Glu Arg Ile Arg Ile Glu Gln Glu Arg Arg Lys Glu
         685                 690                 695

 gct gaa cgg att gct cga gaa aga gag gaa ctc aga agg caa caa cag     2222
 Ala Glu Arg Ile Ala Arg Glu Arg Glu Glu Leu Arg Arg Gln Gln Gln
     700                 705                 710

 cag ctt cgt tat gaa caa gaa aaa agg aat tcc ttg aaa cgc cca cgt     2270
 Gln Leu Arg Tyr Glu Gln Glu Lys Arg Asn Ser Leu Lys Arg Pro Arg
 715                 720                 725                 730

 gat gta gat cat agg cga gat gat cct tac tgg agc gag aat aaa aag     2318
 Asp Val Asp His Arg Arg Asp Asp Pro Tyr Trp Ser Glu Asn Lys Lys
                 735                 740                 745

 ttg tct cta gat aca gat gca cga ttt ggc cat gga tcc gac tac tct     2366
 Leu Ser Leu Asp Thr Asp Ala Arg Phe Gly His Gly Ser Asp Tyr Ser
             750                 755                 760

 cgc caa cag aac aga ttt aat gac ttt gat cac cga gag agg ggc agg     2414
 Arg Gln Gln Asn Arg Phe Asn Asp Phe Asp His Arg Glu Arg Gly Arg
         765                 770                 775

 ttt cct gag agt tca gca gta cag tct tca tct ttt gaa agg cgg gat     2462
 Phe Pro Glu Ser Ser Ala Val Gln Ser Ser Ser Phe Glu Arg Arg Asp
     780                 785                 790

 cgc ttt gtt ggt caa agt gag ggg aaa aaa gca cga cct act gca cga     2510
 Arg Phe Val Gly Gln Ser Glu Gly Lys Lys Ala Arg Pro Thr Ala Arg
 795                 800                 805                 810

 agg gaa gat cca agc ttc gaa aga tat ccc aaa aat ttc agt gac tcc     2558
 Arg Glu Asp Pro Ser Phe Glu Arg Tyr Pro Lys Asn Phe Ser Asp Ser
                 815                 820                 825

 aga aga aat gag cct cca cca cca aga aat gaa ctt aga gaa tca gac     2606
 Arg Arg Asn Glu Pro Pro Pro Pro Arg Asn Glu Leu Arg Glu Ser Asp
             830                 835                 840

 agg cga gaa gta cga ggg gag cga gac gaa agg aga acg gtg att atc     2654
 Arg Arg Glu Val Arg Gly Glu Arg Asp Glu Arg Arg Thr Val Ile Ile
         845                 850                 855

 tca tga caggcctgat atcactcatc ctagacatcc tcgagaggca gggcccaatc      2710
 Ser 






      <210> 170
      <211> 1353
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (295)..(1353)

      <400> 170
 atggctggaa aacaggtcct gctgacacca gaacccatct cttctccact gcctcagttt     60

 acctggagca tctgcatttc agatgcactg cctgagcgac tacagcaaga agcaagagct    120

 tctcactgtc tccgctctcc aaaatgccta aggctctccg cacagtgcct tgactgcaat    180

 caatacccag agatctcatg tacccagcgc cagggagagg aagaaagcag agaaagaggt    240

 gagcgaactc tcttcgccgc tgcactgagc ttctcactgt ctccgctctc caaa  atg     297
                                                              Met
                                                                1

 cct aac act ctc cgt ctc agt gcc ttg act caa gag gcg ctg cca ggc      345
 Pro Asn Thr Leu Arg Leu Ser Ala Leu Thr Gln Glu Ala Leu Pro Gly
               5                  10                  15

 cac tct gtc ctc cgc gtg gcc ttt gtt atg ttc ccc gag ctg gtc agc      393
 His Ser Val Leu Arg Val Ala Phe Val Met Phe Pro Glu Leu Val Ser
          20                  25                  30

 tcg gtg ccc ttc ctt gga gct gcc ggc cac cag cag agc cta ccc tct      441
 Ser Val Pro Phe Leu Gly Ala Ala Gly His Gln Gln Ser Leu Pro Ser
      35                  40                  45

 tca tgg aaa gcc tcg tgc agt ggc ccc ctg gtg atg gca tcc gac agt      489
 Ser Trp Lys Ala Ser Cys Ser Gly Pro Leu Val Met Ala Ser Asp Ser
  50                  55                  60                  65

 gat gtg aag atg ctg ctg aac ttc gtg aac ctg gcg tcc agc gac atc      537
 Asp Val Lys Met Leu Leu Asn Phe Val Asn Leu Ala Ser Ser Asp Ile
                  70                  75                  80

 aag gca gcc ctg gat aag tcc gca ccc tgc cgc cgc tcc gtg gac cat      585
 Lys Ala Ala Leu Asp Lys Ser Ala Pro Cys Arg Arg Ser Val Asp His
              85                  90                  95

 cgc aag tac ctg cag aag cag ctc aag cgc ttc tcc cag aag tat tcc      633
 Arg Lys Tyr Leu Gln Lys Gln Leu Lys Arg Phe Ser Gln Lys Tyr Ser
         100                 105                 110

 cgg ctc ccg cgg ggc ctt cct ggc aga gct gct gag ccc tac ctg aaa      681
 Arg Leu Pro Arg Gly Leu Pro Gly Arg Ala Ala Glu Pro Tyr Leu Lys
     115                 120                 125

 agg ggg tct gag gac cgg ccc agg agg ctg ctc ctg gat ttg ggc cct      729
 Arg Gly Ser Glu Asp Arg Pro Arg Arg Leu Leu Leu Asp Leu Gly Pro
 130                 135                 140                 145

 gat tcc agc ccc ggc ggg ggt ggg ggc tgc aag gag aag gtg ctg agg      777
 Asp Ser Ser Pro Gly Gly Gly Gly Gly Cys Lys Glu Lys Val Leu Arg
                 150                 155                 160

 aac ccc tac agg gag gaa tgt ctt gct aag gag cag ctc cca cag agg      825
 Asn Pro Tyr Arg Glu Glu Cys Leu Ala Lys Glu Gln Leu Pro Gln Arg
             165                 170                 175

 cag cat cca gaa gct gcc cag cct ggc cag gtg ccc atg agg aaa aga      873
 Gln His Pro Glu Ala Ala Gln Pro Gly Gln Val Pro Met Arg Lys Arg
         180                 185                 190

 cag ctg ccc gct tcc ttc tgg gaa gag cca agg ccc acc cac agc tac      921
 Gln Leu Pro Ala Ser Phe Trp Glu Glu Pro Arg Pro Thr His Ser Tyr
     195                 200                 205

 cat gtg ggg ctg gag ggg gga ctg ggc ccc agg gag gga cct ccc tat      969
 His Val Gly Leu Glu Gly Gly Leu Gly Pro Arg Glu Gly Pro Pro Tyr
 210                 215                 220                 225

 gag ggt aag aaa aat tgc aag ggc ttg gag ccc ctg gga cct gag act     1017
 Glu Gly Lys Lys Asn Cys Lys Gly Leu Glu Pro Leu Gly Pro Glu Thr
                 230                 235                 240

 acc ctg gtg tcc atg tct cca agg gcc ctg gct gaa aag gag ccg ctc     1065
 Thr Leu Val Ser Met Ser Pro Arg Ala Leu Ala Glu Lys Glu Pro Leu
             245                 250                 255

 aag atg cct ggg gtc tcc ttg gtg ggc cgc gtc aat gcc tgg agt tgc     1113
 Lys Met Pro Gly Val Ser Leu Val Gly Arg Val Asn Ala Trp Ser Cys
         260                 265                 270

 tgc ccc ttc cag tac cat gga cag ccc atc tat ccg ggc ccc ctg ggg     1161
 Cys Pro Phe Gln Tyr His Gly Gln Pro Ile Tyr Pro Gly Pro Leu Gly
     275                 280                 285

 gca ctg cct cag agt cct gtc ccc agc ctg ggc ctt tgg agg aag agc     1209
 Ala Leu Pro Gln Ser Pro Val Pro Ser Leu Gly Leu Trp Arg Lys Ser
 290                 295                 300                 305

 cca gcc ttt ccc ggg gag ctg gcg cac ctc tgc aag gat gtg gac ggc     1257
 Pro Ala Phe Pro Gly Glu Leu Ala His Leu Cys Lys Asp Val Asp Gly
                 310                 315                 320

 ctg ggg cag aag gtg tgc agg ccc gtg gtg ctg aaa ccc atc ccc acc     1305
 Leu Gly Gln Lys Val Cys Arg Pro Val Val Leu Lys Pro Ile Pro Thr
             325                 330                 335

 aag cca gcc gtg ccc cca ccc atc ttc aat gtc ttt ggc tac ctc tag     1353
 Lys Pro Ala Val Pro Pro Pro Ile Phe Asn Val Phe Gly Tyr Leu 
         340                 345                 350





      <210> 171
      <211> 1969
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (315)..(1595)

      <400> 171
 ggaggggcga aaggacattt tttttgtgct tgctcccgcc tctgttcttc ccccacctgc     60

 cacgtacaga gcccaagttc tcgctaggct tgttgggtca gcgcgattgg ccggggcccg    120

 cgcgagcctg cgagcgaggt gcggcggtcg cgaagggcaa ccgagcgggc cgtgaccacc    180

 gcctccccgc gacgccccag tccagtggcc tcgcgtccgc ccattcagcg gagacctgcg    240

 gagaggcggc ggccgcggcc tccgcaagcc gtctttctct agagttgtat atatagaaca    300

 tcctggagtc cacc  atg aac gga cag ttg gat cta agt ggg aag cta atc     350
                  Met Asn Gly Gln Leu Asp Leu Ser Gly Lys Leu Ile
                    1               5                  10

 atc aaa gct caa ctt ggg gag gat att cgg cga att cct att cat aat      398
 Ile Lys Ala Gln Leu Gly Glu Asp Ile Arg Arg Ile Pro Ile His Asn
          15                  20                  25

 gaa gat att act tat gat gaa tta gtg cta atg atg caa cga gtt ttc      446
 Glu Asp Ile Thr Tyr Asp Glu Leu Val Leu Met Met Gln Arg Val Phe
      30                  35                  40

 aga gga aaa ctt ctg agt aat gat gaa gta aca ata aag tat aaa gat      494
 Arg Gly Lys Leu Leu Ser Asn Asp Glu Val Thr Ile Lys Tyr Lys Asp
  45                  50                  55                  60

 gaa gat gga gat ctt ata aca att ttt gat agt tct gac ctt tcc ttt      542
 Glu Asp Gly Asp Leu Ile Thr Ile Phe Asp Ser Ser Asp Leu Ser Phe
                  65                  70                  75

 gca att cag tgc agt agg ata ctg aaa ctg aca tta ttt gtt aat ggc      590
 Ala Ile Gln Cys Ser Arg Ile Leu Lys Leu Thr Leu Phe Val Asn Gly
              80                  85                  90

 cag cca aga ccc ctt gaa tca agt cag gtg aaa tat ctc cgt cga gaa      638
 Gln Pro Arg Pro Leu Glu Ser Ser Gln Val Lys Tyr Leu Arg Arg Glu
          95                 100                 105

 ctg ata gaa ctt cga aat aaa gtg aat cgt tta ttg gat agc ttg gaa      686
 Leu Ile Glu Leu Arg Asn Lys Val Asn Arg Leu Leu Asp Ser Leu Glu
     110                 115                 120

 cca cct gga gaa cca gga cct tcc acc aat att cct gaa aat gat act      734
 Pro Pro Gly Glu Pro Gly Pro Ser Thr Asn Ile Pro Glu Asn Asp Thr
 125                 130                 135                 140

 gtg gat ggt agg gaa gaa aag tct gct tct gat tct tct gga aaa cag      782
 Val Asp Gly Arg Glu Glu Lys Ser Ala Ser Asp Ser Ser Gly Lys Gln
                 145                 150                 155

 tct act cag gtt atg gca gca agt atg tct gct ttt gat cct tta aaa      830
 Ser Thr Gln Val Met Ala Ala Ser Met Ser Ala Phe Asp Pro Leu Lys
             160                 165                 170

 aac caa gat gaa tca ata aac aat gtt atg tca gcg ttt ggc tta aca      878
 Asn Gln Asp Glu Ser Ile Asn Asn Val Met Ser Ala Phe Gly Leu Thr
         175                 180                 185

 gat gat cag gtt tca ggg cca ccc agt gct cct gca gaa gat cgt tca      926
 Asp Asp Gln Val Ser Gly Pro Pro Ser Ala Pro Ala Glu Asp Arg Ser
     190                 195                 200

 gga aca ccc gac agc att gct tcc tcc tcc tca gca gct cac cca cca      974
 Gly Thr Pro Asp Ser Ile Ala Ser Ser Ser Ser Ala Ala His Pro Pro
 205                 210                 215                 220

 ggc gtt cag cca cag cag cca cca tat aca gga gct cag act caa gca     1022
 Gly Val Gln Pro Gln Gln Pro Pro Tyr Thr Gly Ala Gln Thr Gln Ala
                 225                 230                 235

 ggt cag att gaa ggt cag atg tac caa cag tac cag caa cag gcc ggc     1070
 Gly Gln Ile Glu Gly Gln Met Tyr Gln Gln Tyr Gln Gln Gln Ala Gly
             240                 245                 250

 tat ggt gca cag cag ccg cag gct cca cct cag cag cct caa cag tat     1118
 Tyr Gly Ala Gln Gln Pro Gln Ala Pro Pro Gln Gln Pro Gln Gln Tyr
         255                 260                 265

 ggt att cag tat tca gca agc tat agt cag cag act gga ccc caa caa     1166
 Gly Ile Gln Tyr Ser Ala Ser Tyr Ser Gln Gln Thr Gly Pro Gln Gln
     270                 275                 280

 cct cag cag ttc cag gga tat ggc cag caa cca act tcc cag gca cca     1214
 Pro Gln Gln Phe Gln Gly Tyr Gly Gln Gln Pro Thr Ser Gln Ala Pro
 285                 290                 295                 300

 gct cct gcc ttt tct ggt cag cct caa caa ctg cct gct cag ccg cca     1262
 Ala Pro Ala Phe Ser Gly Gln Pro Gln Gln Leu Pro Ala Gln Pro Pro
                 305                 310                 315

 cag cag tac cag gcg agc aat tat cct gca caa act tac act gcc caa     1310
 Gln Gln Tyr Gln Ala Ser Asn Tyr Pro Ala Gln Thr Tyr Thr Ala Gln
             320                 325                 330

 act tct cag cct act aat tat act gtg gct cct gcc tct caa cct gga     1358
 Thr Ser Gln Pro Thr Asn Tyr Thr Val Ala Pro Ala Ser Gln Pro Gly
         335                 340                 345

 atg gct cca agc caa cct ggg gcc tat caa cca aga cca ggt ttt act     1406
 Met Ala Pro Ser Gln Pro Gly Ala Tyr Gln Pro Arg Pro Gly Phe Thr
     350                 355                 360

 tca ctt cct gga agt acc atg acc cct cct caa gtg ggc cta atc ctt     1454
 Ser Leu Pro Gly Ser Thr Met Thr Pro Pro Gln Val Gly Leu Ile Leu
 365                 370                 375                 380

 atg cgc gta acc gtc ctc cct ttg gtc agg gta tac caa ctg gac ctg     1502
 Met Arg Val Thr Val Leu Pro Leu Val Arg Val Tyr Gln Leu Asp Leu
                 385                 390                 395

 gtt atc gat aag gag gct cct cta cac caa tta atg tta gct gct agc     1550
 Val Ile Asp Lys Glu Ala Pro Leu His Gln Leu Met Leu Ala Ala Ser
             400                 405                 410

 tat tgg cct ccc aaa aga ctc cag tac tat ttt aat ttg tat tga aga     1598
 Tyr Trp Pro Pro Lys Arg Leu Gln Tyr Tyr Phe Asn Leu Tyr 
         415                 420                 425

 agttcagaaa tttaaaagca gagcattttt tatgatatca ttgttggtgt taattggaaa   1658

 gtataatttg ctggggaaca caaagaccaa aatggaaagt tttttcctcc ctgcttaaaa   1718

 atgtagcagc ttcttagtta ctttggaaca ctactcttac atgtataaag tgattgactt   1778

 gactttctag cttcccttgt ccggaggata ttaaaatgct agggtgaggt ttagccatct   1838

 tacttggctt tttactatta acatgatgta ctaaagtaga gccctttgag aatacaagat   1898

 attatgtata aaatgtaaca ctgatgatag gttaataaag atgattgaat ccaaaaaaaa   1958

 aaaaaaaaaa a                                                        1969




      <210> 172
      <211> 2272
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (46)..(1179)

      <400> 172
 atggcccagc cccctttgcc cttgtccatc aaaggtgccg ccagc    atg tct gac      54
                                                      Met Ser Asp
                                                        1

 aaa ctg ccc tac aaa gtt gct gac atc ggc ctg gcc acc tgg gga cac      102
 Lys Leu Pro Tyr Lys Val Ala Asp Ile Gly Leu Ala Thr Trp Gly His
       5                  10                  15

 aag gcc cta gac att gtg gag aat gga tgc cgg gaa cat gca gtg gct      150
 Lys Ala Leu Asp Ile Val Glu Asn Gly Cys Arg Glu His Ala Val Ala
  20                  25                  30                  35

 gtc ttt gcc gag gct ggc atg cca gtg ttc acc tgg aag ggc aaa atg      198
 Val Phe Ala Glu Ala Gly Met Pro Val Phe Thr Trp Lys Gly Lys Met
                  40                  45                  50

 aaa gag ggg tac ccg tgg tgc att gaa cag aca ctg tac ttc aag gac      246
 Lys Glu Gly Tyr Pro Trp Cys Ile Glu Gln Thr Leu Tyr Phe Lys Asp
              55                  60                  65

 ggg ccc ctc aac atg att ctg gac gac ggg ggc gac ctc acc aac ctc      294
 Gly Pro Leu Asn Met Ile Leu Asp Asp Gly Gly Asp Leu Thr Asn Leu
          70                  75                  80

 atc cac acc aag tac ccg cag ctt ctg cca ggc atc cga ggc atc tct      342
 Ile His Thr Lys Tyr Pro Gln Leu Leu Pro Gly Ile Arg Gly Ile Ser
      85                  90                  95

 gag gag acc acg act ggg gtc cac aac ctc tac aag atg atg gcc aat      390
 Glu Glu Thr Thr Thr Gly Val His Asn Leu Tyr Lys Met Met Ala Asn
 100                 105                 110                 115

 ggg atc ctc aag gtg cct gcc atc aat gtc aat gac tcc gtc acc aag      438
 Gly Ile Leu Lys Val Pro Ala Ile Asn Val Asn Asp Ser Val Thr Lys
                 120                 125                 130

 agc aag ttt gac aac ctc tat ggc tgc cgg gag tcc ctc ata gat ggc      486
 Ser Lys Phe Asp Asn Leu Tyr Gly Cys Arg Glu Ser Leu Ile Asp Gly
             135                 140                 145

 atc aag cgg gcc aca gat gtg atg att gcc ggc aag gta gcg gtg gta      534
 Ile Lys Arg Ala Thr Asp Val Met Ile Ala Gly Lys Val Ala Val Val
         150                 155                 160

 gca ggc tat ggt gat gtg ggc aag ggc tgt gcc cag gcc ctg cgg ggt      582
 Ala Gly Tyr Gly Asp Val Gly Lys Gly Cys Ala Gln Ala Leu Arg Gly
     165                 170                 175

 ttc gga gcc cgc gtc atc atc acc gag att gac ccc atc aac gca ctg      630
 Phe Gly Ala Arg Val Ile Ile Thr Glu Ile Asp Pro Ile Asn Ala Leu
 180                 185                 190                 195

 cag gct gcc atg gag ggc tat gag gtg acc acc atg gat gag gcc tgt      678
 Gln Ala Ala Met Glu Gly Tyr Glu Val Thr Thr Met Asp Glu Ala Cys
                 200                 205                 210

 cag gag ggc aac atc ttt gtc acc acc aca ggc tgt att gac atc atc      726
 Gln Glu Gly Asn Ile Phe Val Thr Thr Thr Gly Cys Ile Asp Ile Ile
             215                 220                 225

 ctt ggc cgg cac ttt gag cag atg aag gat gat gcc att gtg tgt aac      774
 Leu Gly Arg His Phe Glu Gln Met Lys Asp Asp Ala Ile Val Cys Asn
         230                 235                 240

 att gga cac ttt gac gtg gag atc gat gtc aag tgg ctc aac gag aac      822
 Ile Gly His Phe Asp Val Glu Ile Asp Val Lys Trp Leu Asn Glu Asn
     245                 250                 255

 gcc gtg gag aag gtg aac atc aag ccg cag gtg gac cgg tat cgg ttg      870
 Ala Val Glu Lys Val Asn Ile Lys Pro Gln Val Asp Arg Tyr Arg Leu
 260                 265                 270                 275

 aag aat ggg cgc cgc atc atc ctg ctg gcc gag ggt cgg ctg gtc aac      918
 Lys Asn Gly Arg Arg Ile Ile Leu Leu Ala Glu Gly Arg Leu Val Asn
                 280                 285                 290

 ctg ggt tgt gcc atg ggc cac ccc agc ttc gtg atg agt aac tcc ttc      966
 Leu Gly Cys Ala Met Gly His Pro Ser Phe Val Met Ser Asn Ser Phe
             295                 300                 305

 acc aac cag gtg atg gcg cag atc gag ctg tgg acc cat cca gac aag     1014
 Thr Asn Gln Val Met Ala Gln Ile Glu Leu Trp Thr His Pro Asp Lys
         310                 315                 320

 tac ccc gtt ggg gtt cat ttc ctg ccc aag aag ctg gat gag gca gtg     1062
 Tyr Pro Val Gly Val His Phe Leu Pro Lys Lys Leu Asp Glu Ala Val
     325                 330                 335

 gct gaa gcc cac ctg ggc aag ctg aat gtg aag ttg acc aag cta act     1110
 Ala Glu Ala His Leu Gly Lys Leu Asn Val Lys Leu Thr Lys Leu Thr
 340                 345                 350                 355

 gag aag caa gcc cag tac ctg ggc atg tcc tgt gat ggc ccc ttc aag     1158
 Glu Lys Gln Ala Gln Tyr Leu Gly Met Ser Cys Asp Gly Pro Phe Lys
                 360                 365                 370

 ccg gat cac tac cgc tac tga ga gccaggtctg cgtttcaccc tccagctgct     1211
 Pro Asp His Tyr Arg Tyr 
             375

 gtccttgccc aggccccacc tctcctccct aagagctaat ggcaccaact ttgtgattgg   1271

 tttgtcagtg tcccccatcg actctctggg gctgatcact tagtttttgg cctctgctgc   1331

 agccgtcata ctgttccaaa tgtggcagcg ggaacagagt accctcttca agccccggtc   1391

 atgatggagg tcccagccac agggaaccat gagctcagtg gtcttggaac agctcactaa   1451

 gtcagtcctt ccttagcctg gaagtcagta gtggagtcac aaagcccatg tgttttgcca   1511

 tctaggcctt cacctggtct gtggacttat acctgtgtgc ttggtttaca ggtccagtgg   1571

 ttcttcagcc catgacagat gagaaggggc tatattgaag ggcaaagagg aactgttgtt   1631

 tgaattttcc tgagagcctg gcttagtgct gggccttctc ttaaacctca ttacaatgag   1691

 gttagtactt ttagtccctg ttttacaggg gttagaatag actgttaagg ggcaactgag   1751

 aaagaacaga gaagtgacag ctaggggttg agaggggcca gaaaaacatg aatgcaggca   1811

 gatttcgtga aatctgccac cactttataa ccagatggtt cctttcacaa ccctgggtca   1871

 aaaagagaat aatttggcct ataatgttaa aagaaagcag gaaggtgggt aaataaaaat   1931

 cttggtgcct ggcacacccc cccccccccc cccaaccccc ccgcgcccca cccccgccgc   1991

 gcccaccccc gcccctccct ccgccccctg cccctccctg cccctgcccc cccttctctg   2051

 gcccccgcgg cccccccccc gccaccccta tacagcgccc caccaccctc cgacaccccg   2111

 cgggcccccg tatacgcccc ccaccccacc ccccacccac cacacccacc acccccccac   2171

 cccccccccc cacccacccc accccccccc ccacccccac cccacccccc cccacccccc   2231

 cctccccccc cccccccccc cccccccccc cccccccctg g                       2272




      <210> 173
      <211> 1912
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (47)..(475)

      <400> 173
 gatgtaaatt tgtggaaaga agttgttttc gatcaacttt tgtccg   atg tta cac      55
                                                      Met Leu His
                                                        1

 acc ttg tac cgt caa ccc cac aaa tta cag ggt tta aca att tat tta      103
 Thr Leu Tyr Arg Gln Pro His Lys Leu Gln Gly Leu Thr Ile Tyr Leu
       5                  10                  15

 ggg aaa tac ttg ttt tct tac ccc ccc ccc cgc caa aag gac cct caa      151
 Gly Lys Tyr Leu Phe Ser Tyr Pro Pro Pro Arg Gln Lys Asp Pro Gln
  20                  25                  30                  35

 aaa ttc ccc atg ttt acc gcg ccc gca cta att ctt gaa ccc ctg ccg      199
 Lys Phe Pro Met Phe Thr Ala Pro Ala Leu Ile Leu Glu Pro Leu Pro
                  40                  45                  50

 ttc acg ccc gat gta caa agg tgt atg cac aac gtg caa ttc tta cca      247
 Phe Thr Pro Asp Val Gln Arg Cys Met His Asn Val Gln Phe Leu Pro
              55                  60                  65

 gcc aca caa aag cat gct caa aca gat gtc aca gtt cag tca cct ccc      295
 Ala Thr Gln Lys His Ala Gln Thr Asp Val Thr Val Gln Ser Pro Pro
          70                  75                  80

 att ggc cat ggc aca cag cag gtt tac ggg atg ttt ccc aat agt ggt      343
 Ile Gly His Gly Thr Gln Gln Val Tyr Gly Met Phe Pro Asn Ser Gly
      85                  90                  95

 tat tac aca gtc agc acc act gtg aat ttt gtg aat ttg aaa aaa aaa      391
 Tyr Tyr Thr Val Ser Thr Thr Val Asn Phe Val Asn Leu Lys Lys Lys
 100                 105                 110                 115

 agt gta att tat gga ttc agg att caa aaa gaa tca ttt tgt atc gaa      439
 Ser Val Ile Tyr Gly Phe Arg Ile Gln Lys Glu Ser Phe Cys Ile Glu
                 120                 125                 130

 ttt acc cca gac aaa ggg aaa act ggt tgc gac tga aact tggctataga      489
 Phe Thr Pro Asp Lys Gly Lys Thr Gly Cys Asp 
             135                 140

 tagcttgatg tcccaatatt caaacaataa gccaactctc cattttcaag taaatccagc    549

 ttcatccaca gagaaacaga caattttcta acctcaagag caaccagctt gttacatttt    609

 ccctatccta tggcaggaaa tgcgtattac ttctgttctg tttaagcatc tcagtctaaa    669

 tgccatgaag accagagccc aggtttcttc cttttcaaat tcttaaggtg aaagtttttt    729

 cctttcagtg cagctaccaa tgatgcaggc aaagaactgt tcaagccagc actcattctt    789

 caaagctgca acagtggcca ccatgatctt ttataaagct ttccccgttg ctcctgatat    849

 ttatttctgc ttttgcctaa cgctctcaaa gcatctcgta aactgaagtt taaagaaaag    909

 cacgattccc atccccaacc agtacttgaa aatccactta tctgaatgtt cacagataaa    969

 aaagccatta aaaaaaagag tcaagtttag tctagctgac catattcaca agtgttaaaa   1029

 actttactgg agtataacct caaatttcac tcttgatttg ttatctgtaa gaaaatgcta   1089

 tttgagccag taccaaatta agtattaaaa tgaggattga actggggcaa acaggttatt   1149

 gtgaaaacag tcaatatgta agctccttca agggaaatca actactgttc ctcaagatta   1209

 gaagatgtcc acactctttg cattacctcc ctaaaggagg aaacacccat taattttccc   1269

 ttatggaatc aatatggagt ggaaatatga aatgaggaga tgttttagaa agcaggacaa   1329

 atctacctac cattactgga attaaaatgt atcctctcgg ggcccactcc acttgatgtc   1389

 cgatcgtgag gtgagtgagg acataaaagc agcaccaggt ctacacgaag agactgacat   1449

 aagatggaca agtatgctac gtattgctct agcctgggga caggccgggg actctggaag   1509

 aacacgaatc tttagagaac tacgacatgt atgtgtcagt gcagctatag cttgctcgaa   1569

 agtctacgtt cgtagaggct aaacgctagc gagagtctaa gatcaagaca agcacctctc   1629

 aaagcttaag cgtcccactt gccgtgagcg actgcgaaat acgcacaggt gaactgctat   1689

 tcgccatctt cacacatagg tcacacgtag aggaaaacag aggaagcgtt agctcaaggt   1749

 atggtgccaa tggctcagtc aggtatcgtg cttacatgct tgtaatgcgt cgctgacact   1809

 cactcatcaa gccttcgatc tattgagcac ctgtatccag ttgagtcacc acctctgtcc   1869

 tcctattttg catgcatgat ttgaggggaa gactagagtg ttt                     1912




      <210> 174
      <211> 2365
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1549)..(1974)

      <400> 174
 cctgtaagga ccttgatatc caaaggacag ctgaagaaag taatgtgcct gcatttttgc     60

 cacttcattc ccacagtgcc cgaaatgcca gctcctcctt ggtgttctcc tttcaggatt    120

 tgaattcaaa tcccattggc agccctgata ccgctggggg aagggtgagg taggaaaagt    180

 cccaccaata tcctaagggg aggtgcgagt ggctaccagg atgtgagatg tctgtgggca    240

 aagtccctgc ttattccatg aggggctgtg ggattaggac tgtggctgga tgcctcttcc    300

 tccaacaact ccatctcagg atgaagctga ggctttaaaa ccctgacaaa ctgtgggtga    360

 ctgtctctac ttaattcctc ctcccaaact cttggtgtct ggttttttcc ctctttctgc    420

 cctgggcctg gagcagctgt ccagagaccc ccaccatgac tcatactctc ctgttctccc    480

 tccctctccc ctctctatta acctcaccct tcccaatcca gtggggtagt attaagtccc    540

 agtcgcagat ggggcaataa tgtcccagca cccctccctc cacacaccca gggcttcctg    600

 ttctttccac cctcaccctg aagagctgca gggtggtggg gggaggcaaa ggctcattac    660

 tttataagat tttcattact ttataagatt tcattttaca ttttacttaa gtgtacttgt    720

 ttcagagagt ggtaaagaca gatcctgctc ctctcaatcc aatcctgtag atttcttcag    780

 ttacctcaac agggtcatac tggctcctga aatgggcacc attatttaaa agaaatagag    840

 gtacagagtc ctcaagattt atgggcacct gagtttctgc cccgtgcccc gctgcaggtt    900

 tcccaatccc ctaaagacat tcatggatgg gtgagaggag ctgacacctc ccgctctgtg    960

 accactttct ctttggccat ggaggaagtc ttgctgcccc tggctgtgac atctgacccc   1020

 aggcccttta atcaacaact cccagagcct ccagacccaa gatgtgtttt ggaaccccag   1080

 gacaatcctg aactggcact tgccctggtg tgtgcccttt gctgctgctt tggaatcatc   1140

 tactgctgct tcagtgaggg cagggccaag gacctggggg gccattgccc aagactgtca   1200

 tcctcaagga tgatgccagc tttcctcctt gctcctgggc catctcacct cctctgccag   1260

 gggttcctac ctctagtgtg gcccatgttg ctctggctgt attcctaggc ccatgttgct   1320

 cttgccagct tcttgtccat cctccatgcc catgccttcc agctttcacc tctggcatct   1380

 atcatttgct cttctcttaa ctcctacctg aaaaccccat tcctaaatta ttcactatat   1440

 ttcagacttc ttcactcttc tccaaaaacc tgaatcagct tgtgctgatt ttttcctatc   1500

 tgctatccct aaaaggacta gaccttcttt ctatccttac tcccctca atg tat cca    1557
                                                      Met Tyr Pro
                                                        1

 tct tac ctc ttg att ttc cct ccc att ccc tca cag ttc ctg aaa cag     1605
 Ser Tyr Leu Leu Ile Phe Pro Pro Ile Pro Ser Gln Phe Leu Lys Gln
       5                  10                  15

 tgc ccc ccc ccg acc cta agc gac ccc ttt ctg ccc ctg gcc ttg agg     1653
 Cys Pro Pro Pro Thr Leu Ser Asp Pro Phe Leu Pro Leu Ala Leu Arg
  20                  25                  30                  35

 tcc ctt gac gtg ctg ctc ctg tct tct gct cct cta gtg agc cat tcc     1701
 Ser Leu Asp Val Leu Leu Leu Ser Ser Ala Pro Leu Val Ser His Ser
                  40                  45                  50

 tct ccc ttg gaa ttc atc aga gtc atc cct gta gag ccc cct tcc tgc     1749
 Ser Pro Leu Glu Phe Ile Arg Val Ile Pro Val Glu Pro Pro Ser Cys
              55                  60                  65

 ctc tca att cct cct gcc tca ctt ccc agg cta ctg ctg ctt caa gac     1797
 Leu Ser Ile Pro Pro Ala Ser Leu Pro Arg Leu Leu Leu Leu Gln Asp
          70                  75                  80

 agt gac gtt tct ctc cgg tca gct gtc agg agc gct ggt gag ctt cct     1845
 Ser Asp Val Ser Leu Arg Ser Ala Val Arg Ser Ala Gly Glu Leu Pro
      85                  90                  95

 act gtg cca caa ggt gcg ggt gct gga gac aca gct gag cct gga aat     1893
 Thr Val Pro Gln Gly Ala Gly Ala Gly Asp Thr Ala Glu Pro Gly Asn
 100                 105                 110                 115

 gag agt ggg cat cgc cgt ggt cat cat gac tcc tct gcg gcg tgg tca     1941
 Glu Ser Gly His Arg Arg Gly His His Asp Ser Ser Ala Ala Trp Ser
                 120                 125                 130

 cca tgt tgg ttc act gtg ttg ggc tct tat tga cgggtctc ctgctaggcc     1992
 Pro Cys Trp Phe Thr Val Leu Gly Ser Tyr 
             135                 140

 tgaccttggg tgccggagcc ctgctggctt ctgagcctat ctaccaacca ccttcagcct   2052

 gggtgccagc tggggggctg gtggggctgg cgctgctggg agccctgctc acacttcggt   2112

 ggccacgtcc attcacagtt ctgggcacaa ccctgctggg ttctgcagtg cttgtggcct   2172

 gtgttgacta cttcctggag gggctggcac tggggagttg gctgggccaa cgcctgcaga   2232

 cacttccagc cttgccttct ctctgctgat atagctgggt cttactgggg atctggccag   2292

 ccttgggggc ccttggagcc ctggcccagt ggaagctcgt gcctgaagaa catggaggtc   2352

 tcgctataga gac                                                      2365




      <210> 175
      <211> 2226
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (124)..(1044)

      <220>
      <221> misc_feature
      <222> (1)...(2226)
      <223> n = a,t,c or g

      <400> 175
 aagagtgata tcctgtccct ggaggagatt ctggccgagg ggactgacct ggcggagaca     60

 gccccgcccc ccttgtgcgc cagccgcaac agcaaggcca aactgagggc cctgagggag    120

 gcc  atg tat cac agc gct gag cat ggc tac gtg gat gtc aca att gat     168
      Met Tyr His Ser Ala Glu His Gly Tyr Val Asp Val Thr Ile Asp
        1               5                  10                  15

 atc agg agc ata ggc gtc ccg tgg act ctg cac acg tgg ctg gag tct      216
 Ile Arg Ser Ile Gly Val Pro Trp Thr Leu His Thr Trp Leu Glu Ser
                  20                  25                  30

 ttg cgg atc gcc ttc cag cag cac cgc agg cct ctc atc cag tgc ttg      264
 Leu Arg Ile Ala Phe Gln Gln His Arg Arg Pro Leu Ile Gln Cys Leu
              35                  40                  45

 tta aag gag ttt aag acc att cag gag gag gaa tac acg gag gag ctc      312
 Leu Lys Glu Phe Lys Thr Ile Gln Glu Glu Glu Tyr Thr Glu Glu Leu
          50                  55                  60

 gtt acc caa ggc ctg ccc ctg atg ttt gag atc ctg aaa gcg agc aag      360
 Val Thr Gln Gly Leu Pro Leu Met Phe Glu Ile Leu Lys Ala Ser Lys
      65                  70                  75

 aat gaa gtg atc agc cag cag ctg tgc gtc atc ttc aca cac tgc tac      408
 Asn Glu Val Ile Ser Gln Gln Leu Cys Val Ile Phe Thr His Cys Tyr
  80                  85                  90                  95

 ggg ccc tac ccc atc ccc aag ctc aca gaa atc aaa cgg aaa cag acc      456
 Gly Pro Tyr Pro Ile Pro Lys Leu Thr Glu Ile Lys Arg Lys Gln Thr
                 100                 105                 110

 tcg cgc ttg gat cct cat ttt ctt aac aat aaa gaa atg tct gat gtt      504
 Ser Arg Leu Asp Pro His Phe Leu Asn Asn Lys Glu Met Ser Asp Val
             115                 120                 125

 aca ttt ctg gta gaa gga aga cca ttt tat gct cac aaa gtg ctg tta      552
 Thr Phe Leu Val Glu Gly Arg Pro Phe Tyr Ala His Lys Val Leu Leu
         130                 135                 140

 ttt aca gcc tct cca agg ttc aaa gca ctc ctc tcc agc aag ccg aca      600
 Phe Thr Ala Ser Pro Arg Phe Lys Ala Leu Leu Ser Ser Lys Pro Thr
     145                 150                 155

 aat gat ggc acc tgc ata gag att ggt tat gtg aaa tac tcc atc ttt      648
 Asn Asp Gly Thr Cys Ile Glu Ile Gly Tyr Val Lys Tyr Ser Ile Phe
 160                 165                 170                 175

 cag ctg gtt atg cag tat ctc tac tat ggt ggc cca gag tca ctg ctc      696
 Gln Leu Val Met Gln Tyr Leu Tyr Tyr Gly Gly Pro Glu Ser Leu Leu
                 180                 185                 190

 att aaa aac aat gag atc atg gag ctt ctg tct gct gct aag ttt ttc      744
 Ile Lys Asn Asn Glu Ile Met Glu Leu Leu Ser Ala Ala Lys Phe Phe
             195                 200                 205

 cag ctg gag gct ttg cag cga cac tgt gag att atc tgt gcg aaa agc      792
 Gln Leu Glu Ala Leu Gln Arg His Cys Glu Ile Ile Cys Ala Lys Ser
         210                 215                 220

 atc aat acc gac aac tgt gtg gat att tac aac cat gcc aag ttt ctt      840
 Ile Asn Thr Asp Asn Cys Val Asp Ile Tyr Asn His Ala Lys Phe Leu
     225                 230                 235

 gga gtc aca gag ctc tca gca tat tgc gaa ggc tac ttt ctc aaa aac      888
 Gly Val Thr Glu Leu Ser Ala Tyr Cys Glu Gly Tyr Phe Leu Lys Asn
 240                 245                 250                 255

 atg atg gtc ctc att gaa aac gaa gca ttc aag cag ctc ctg tat gac      936
 Met Met Val Leu Ile Glu Asn Glu Ala Phe Lys Gln Leu Leu Tyr Asp
                 260                 265                 270

 aaa aat ggt gaa ggg acc ggc cag gat gtg ctc cag gac tta cag agg      984
 Lys Asn Gly Glu Gly Thr Gly Gln Asp Val Leu Gln Asp Leu Gln Arg
             275                 280                 285

 acg ttg gcc atc aga att cag tcc atc cac ttg tcg tct tcc aaa ggt     1032
 Thr Leu Ala Ile Arg Ile Gln Ser Ile His Leu Ser Ser Ser Lys Gly
         290                 295                 300

 tcc gtg gta tga aac gcctagtgca gggaatgctt cccgggaact ttccagttct     1087
 Ser Val Val 
     305

 cctgccgcat tggctttaca caaacacaga caaattccac ctggcacctg tttttggctg   1147

 ggccaaggag ctgcctctac tgctcccacg tgttcctgtt gaaaaacaaa ggactttcca   1207

 ctggtctgca gatcagatca gctgggtcca gagtttaatg ggcaactgga caaccaagtt   1267

 aaccccaatt gaaagcaccc ctaggaccat tgaacaccca ctgccgggga ccactgtcca   1327

 gtgaatggat tgaggccttt taaaggtcac tcaggttcca ggttgacagt tggaggactt   1387

 caccgtacca accctgaaga gattgtatta cacattaagg accttggtag ctgtgcttca   1447

 gcaaacgtca accatggtag caaattggtg aggctgtgac caataatgag gaaataatct   1507

 ggcaaatttt taggggtggg aactttttta aatgttcatt taaaaaaaaa caaaaacagg   1567

 gcagtcttgt agtttaaaat atatttctaa aagcttaaca gttcgttttc aactaaattg   1627

 tgtttaggga tctgtgtttg agatttttct ttatttcttt ttttttttta aatagtaagt   1687

 cacaggtcca cactgtgtaa acatgcatct gataagatac tgctgatatt ctaaacaagt   1747

 tgaaataatc ttgccttagt gatcatgatt acacaaaaga ggtgcactgc caataagtat   1807

 ctctaattca atagttgaaa gcaacctgca tgctaatcgt ggtttcgggg tgagaataaa   1867

 acacccccac ataacatgca tttgcatggg cccgaacctg tgaaatgtta cgtttgtgct   1927

 tcatttttgc caaggtaaaa atgttccatc atttctagct aaaactccat ttggtggaac   1987

 caacatatcc atttcttttc ctagttacgg atgatttggg gatgcttttg cagaaatgtg   2047

 ttcatagatg atgctgaatg gnggaggggg gcnnnnnnnn nnnnnnnnng nntnnnnnnn   2107

 gngntnngtg gggggtgngn ggaggggggg gnnggttttc ccgttttggg tttttgtggt   2167

 ttttggtttg tttttttttt tggggttgat ttttggtttg gttggtttgt atgtttttt    2226




      <210> 176
      <211> 984
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (118)..(984)

      <400> 176
 atgaagtcaa ggttaaaaac aacacactgg ggtggcggcg gcagcgagga cagcggtcgg     60

 cagggtgcct ttgtcgcatt ccctgagaga agcggtgtct gtgaggtggt gtccatc       117                                                                 
 atg ttc tct ttc aac atg ttc aac cac cta att ccc agg gtc ttc caa      165
 Met Phe Ser Phe Asn Met Phe Asn His Leu Ile Pro Arg Val Phe Gln
   1               5                  10                  15

 aac cgc ttc tcc aca cac tac cgc tgc ttc tct gtg tcc acg cta gca      213
 Asn Arg Phe Ser Thr His Tyr Arg Cys Phe Ser Val Ser Thr Leu Ala
              20                  25                  30

 ggg cct aat gac aag tca gat gtg gag aaa gga ggg aag ata att atg      261
 Gly Pro Asn Asp Lys Ser Asp Val Glu Lys Gly Gly Lys Ile Ile Met
          35                  40                  45

 ctg ccc tca gcc ctg gac caa ctc agc caa ctt aac att acc tat ccc      309
 Leu Pro Ser Ala Leu Asp Gln Leu Ser Gln Leu Asn Ile Thr Tyr Pro
      50                  55                  60

 atg ctg ttc aaa ctg acc agt aag aat ttg gac cgc atg acg cac tgt      357
 Met Leu Phe Lys Leu Thr Ser Lys Asn Leu Asp Arg Met Thr His Cys
  65                  70                  75                  80

 ggc gtg ctg gag ttt gtg gct gat gag ggc atc tgc tac ctc cca cac      405
 Gly Val Leu Glu Phe Val Ala Asp Glu Gly Ile Cys Tyr Leu Pro His
                  85                  90                  95

 tgg atg atg cag aac ttg ctc ttg gaa gaa ggc agc ctg cct cag agc      453
 Trp Met Met Gln Asn Leu Leu Leu Glu Glu Gly Ser Leu Pro Gln Ser
             100                 105                 110

 cct gac atc ctg gac atc act aac ccc aaa gct gta tta gac aac gca      501
 Pro Asp Ile Leu Asp Ile Thr Asn Pro Lys Ala Val Leu Asp Asn Ala
         115                 120                 125

 ctt agg aac ttt gcc tgt ctg acc acc ggg aat gtg act gcc atc aac      549
 Leu Arg Asn Phe Ala Cys Leu Thr Thr Gly Asn Val Thr Ala Ile Asn
     130                 135                 140

 tgt aat gaa aag atc tat gaa ctc gaa ctg cgt gtg atg gaa acc aaa      597
 Cys Asn Glu Lys Ile Tyr Glu Leu Glu Leu Arg Val Met Glu Thr Lys
 145                 150                 155                 160

 ccc aac aag gca gtg tcc atc act gag tgt gac aca aac gtg gac tct      645
 Pro Asn Lys Ala Val Ser Ile Thr Glu Cys Asp Thr Asn Val Asp Ser
                 165                 170                 175

 gat gct ccc ctg ggc tac aaa gaa ccc gaa aga caa gtc cag cac gag      693
 Asp Ala Pro Leu Gly Tyr Lys Glu Pro Glu Arg Gln Val Gln His Glu
             180                 185                 190

 gag ttg aca gaa ggt gaa gcc gac cac agt ggc tat gct gga gag ctg      741
 Glu Leu Thr Glu Gly Glu Ala Asp His Ser Gly Tyr Ala Gly Glu Leu
         195                 200                 205

 ggc ttc cgt gcc ttc tcc ggc tct ggc aac aga ctg gat gga aag aaa      789
 Gly Phe Arg Ala Phe Ser Gly Ser Gly Asn Arg Leu Asp Gly Lys Lys
     210                 215                 220

 gaa agc ccc tcc cca atc aag cct gga gac att aaa aga gga att ccc      837
 Glu Ser Pro Ser Pro Ile Lys Pro Gly Asp Ile Lys Arg Gly Ile Pro
 225                 230                 235                 240

 aat cat gaa ttt aaa ctt ggt aag aca cct ttc atc aga aat gca tgt      885
 Asn His Glu Phe Lys Leu Gly Lys Thr Pro Phe Ile Arg Asn Ala Cys
                 245                 250                 255

 ccc ctt gtc aaa aag ttt gaa gag gat gaa gct gga ggc aga ttc gtt      933
 Pro Leu Val Lys Lys Phe Glu Glu Asp Glu Ala Gly Gly Arg Phe Val
             260                 265                 270

 gct ttc tct gga gaa gga cag tcg ttg agt aaa aag gga aga aag ccc      981
 Ala Phe Ser Gly Glu Gly Gln Ser Leu Ser Lys Lys Gly Arg Lys Pro
         275                 280                 285

 taa                                                                  984
 






      <210> 177
      <211> 246
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (28)..(237)

      <400> 177
 atcacctggt ccgggataag aaagatc    atg gaa gaa gag agc acc cat aag      51
                                  Met Glu Glu Glu Ser Thr His Lys
                                    1               5

 gag aaa ctg gag gct ctc cat cca gag ccc aac cct aaa aag tcc cct       99
 Glu Lys Leu Glu Ala Leu His Pro Glu Pro Asn Pro Lys Lys Ser Pro
      10                  15                  20

 gca aag gag aga gag gag gta ccc aaa aag aaa aag gaa aat gct gac      147
 Ala Lys Glu Arg Glu Glu Val Pro Lys Lys Lys Lys Glu Asn Ala Asp
  25                  30                  35                  40

 act ggc agg gag ggg aat aac cct gca gaa aat gaa gat gcc aaa aca      195
 Thr Gly Arg Glu Gly Asn Asn Pro Ala Glu Asn Glu Asp Ala Lys Thr
                  45                  50                  55

 gac cag gca cag aaa gct gaa ggt gct gga gat gcc aag tga agtgtgt      244
 Asp Gln Ala Gln Lys Ala Glu Gly Ala Gly Asp Ala Lys 
              60                  65

 gc                                                                   246




      <210> 178
      <211> 900
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(900)

      <400> 178
  atg aac atc gtc ttc tcc agg gac agc cag gtg agg gtg atg gag aat      48
  Met Asn Ile Val Phe Ser Arg Asp Ser Gln Val Arg Val Met Glu Asn
    1               5                  10                  15

 acc gtg gcc aac acc gag aag tac ttt ggg cag ttc tgc tcg ctg ctg       96
 Thr Val Ala Asn Thr Glu Lys Tyr Phe Gly Gln Phe Cys Ser Leu Leu
              20                  25                  30

 gcc gcc tac acg cgc aag acg gcc cgg ctg cgg gac aag gcg gac cag      144
 Ala Ala Tyr Thr Arg Lys Thr Ala Arg Leu Arg Asp Lys Ala Asp Gln
          35                  40                  45

 ctg gtc aag cag ctc atc gac ttt gcc aac tcc gag aac ccc gag ctg      192
 Leu Val Lys Gln Leu Ile Asp Phe Ala Asn Ser Glu Asn Pro Glu Leu
      50                  55                  60

 cgg gcc acc atg agg ggc ttc gct gag gac ctg gcc aaa gtg cag gat      240
 Arg Ala Thr Met Arg Gly Phe Ala Glu Asp Leu Ala Lys Val Gln Asp
  65                  70                  75                  80

 tac cgg cag gcc cag gtc gag agg ctg gag acc aag gtg gtc aac ccc      288
 Tyr Arg Gln Ala Gln Val Glu Arg Leu Glu Thr Lys Val Val Asn Pro
                  85                  90                  95

 ctg aag ctc tac ggg gca cag atc aag cag aca cgg gct gag atc aag      336
 Leu Lys Leu Tyr Gly Ala Gln Ile Lys Gln Thr Arg Ala Glu Ile Lys
             100                 105                 110

 aaa ttc aaa cat gtc caa aat cat gag atc aaa caa ctg gaa aaa ctg      384
 Lys Phe Lys His Val Gln Asn His Glu Ile Lys Gln Leu Glu Lys Leu
         115                 120                 125

 gag aaa ctg agg cag aag tca ccc tcg gat cag caa atg atc tcc cag      432
 Glu Lys Leu Arg Gln Lys Ser Pro Ser Asp Gln Gln Met Ile Ser Gln
     130                 135                 140

 gca gag acc aga gtg cag agg gcc gct gtg gac tcc agc cgc acc acc      480
 Ala Glu Thr Arg Val Gln Arg Ala Ala Val Asp Ser Ser Arg Thr Thr
 145                 150                 155                 160

 ctc cag ctg gag gag act gtg gat ggc ttc cag agg cag aag ctc aag      528
 Leu Gln Leu Glu Glu Thr Val Asp Gly Phe Gln Arg Gln Lys Leu Lys
                 165                 170                 175

 gac ctg cag aaa ttt ttt tgt gac ttt gta act att gag atg gtt ttc      576
 Asp Leu Gln Lys Phe Phe Cys Asp Phe Val Thr Ile Glu Met Val Phe
             180                 185                 190

 cat gcc aaa gcg gtg gag gtg tat tct agc gcc ttc cag acc ctg gag      624
 His Ala Lys Ala Val Glu Val Tyr Ser Ser Ala Phe Gln Thr Leu Glu
         195                 200                 205

 aag tat gac ctg gag agg gat cta ctg gat ttt aga gcc aag atg caa      672
 Lys Tyr Asp Leu Glu Arg Asp Leu Leu Asp Phe Arg Ala Lys Met Gln
     210                 215                 220

 gga gtt tat ggg cat tat gac act cgg ctg ctt gcc aac acc agc ccc      720
 Gly Val Tyr Gly His Tyr Asp Thr Arg Leu Leu Ala Asn Thr Ser Pro
 225                 230                 235                 240

 cct cca tct gtt ctt cag tct ctc gcc agc cag agt gct cag agc acc      768
 Pro Pro Ser Val Leu Gln Ser Leu Ala Ser Gln Ser Ala Gln Ser Thr
                 245                 250                 255

 ata tgg agc cca gga aaa gaa ggg gag gag agt gag gac aac tcc atg      816
 Ile Trp Ser Pro Gly Lys Glu Gly Glu Glu Ser Glu Asp Asn Ser Met
             260                 265                 270

 gag gag gcc ccc gtg gag gac ctc agg gca ctg ggg cag gga ccc cat      864
 Glu Glu Ala Pro Val Glu Asp Leu Arg Ala Leu Gly Gln Gly Pro His
         275                 280                 285

 aag aga gaa ctg ccc aca aca gtc aga aga act tag                      900
 Lys Arg Glu Leu Pro Thr Thr Val Arg Arg Thr 
     290                 295





      <210> 179
      <211> 324
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (25)..(324)

      <400> 179
 cggccgcgtc gacgtgcctc caag   atg aca aag aaa aga agg aac aat ggt      51
                              Met Thr Lys Lys Arg Arg Asn Asn Gly
                                1               5

 cgt gcc aaa aag ggc cgc ggc cac gtg cag cct att cgc tgc act aac       99
 Arg Ala Lys Lys Gly Arg Gly His Val Gln Pro Ile Arg Cys Thr Asn
  10                  15                  20                  25

 tgt gcc cga tgc atg ccc aag gac aag gcc att aag aaa ttc atc att      147
 Cys Ala Arg Cys Met Pro Lys Asp Lys Ala Ile Lys Lys Phe Ile Ile
                  30                  35                  40

 cga aac ata gtg gag gcc gca gca atc agg gac att tct gaa gcg agc      195
 Arg Asn Ile Val Glu Ala Ala Ala Ile Arg Asp Ile Ser Glu Ala Ser
              45                  50                  55

 gtc ttc gat gcc aat gag ctt ccc aag ctg tat gtg aag cta cct tac      243
 Val Phe Asp Ala Asn Glu Leu Pro Lys Leu Tyr Val Lys Leu Pro Tyr
          60                  65                  70

 tgt gtg agt tgt gca att cac agc aaa gta gtc agg aat cga tct cat      291
 Cys Val Ser Cys Ala Ile His Ser Lys Val Val Arg Asn Arg Ser His
      75                  80                  85

 gaa gcc cgc aag gac cga aca ccc cca cct tga                          324
 Glu Ala Arg Lys Asp Arg Thr Pro Pro Pro 
  90                  95





      <210> 180
      <211> 1410
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(609)

      <400> 180
  atg agc agc ggc tac agc agc ctg gag gag gac gcc gag gac ttc ttc      48
  Met Ser Ser Gly Tyr Ser Ser Leu Glu Glu Asp Ala Glu Asp Phe Phe
    1               5                  10                  15

 ttc acc gcc agg acc tcc ttc ttc agg aga gcg ccc cag ggc aag ccc       96
 Phe Thr Ala Arg Thr Ser Phe Phe Arg Arg Ala Pro Gln Gly Lys Pro
              20                  25                  30

 cgc tcc ggc caa caa aat tca aat ggg att tac act ggc ttc att aaa      144
 Arg Ser Gly Gln Gln Asn Ser Asn Gly Ile Tyr Thr Gly Phe Ile Lys
          35                  40                  45

 gta cag atg gaa ctc tgc aaa cct cca cag act tct cca aat tct gga      192
 Val Gln Met Glu Leu Cys Lys Pro Pro Gln Thr Ser Pro Asn Ser Gly
      50                  55                  60

 aaa ctc tct ccc agt agc aat ggc tgt atg aat aca ctt cat atc agc      240
 Lys Leu Ser Pro Ser Ser Asn Gly Cys Met Asn Thr Leu His Ile Ser
  65                  70                  75                  80

 agc aca aac act gtc ggg gaa gtg atc gag gcc ctg ctc aaa aag ttt      288
 Ser Thr Asn Thr Val Gly Glu Val Ile Glu Ala Leu Leu Lys Lys Phe
                  85                  90                  95

 ctc gtg act gag agc cct gcc aag ttt gca ctt tat aag cgt tgt cac      336
 Leu Val Thr Glu Ser Pro Ala Lys Phe Ala Leu Tyr Lys Arg Cys His
             100                 105                 110

 agg gaa gac caa gtc tac gcc tgc aag ctc tca gac cgg gaa cat cca      384
 Arg Glu Asp Gln Val Tyr Ala Cys Lys Leu Ser Asp Arg Glu His Pro
         115                 120                 125

 ctc tac ctg cgt ttg gta gca ggg ccc aga aca gac aca ctt agt ttt      432
 Leu Tyr Leu Arg Leu Val Ala Gly Pro Arg Thr Asp Thr Leu Ser Phe
     130                 135                 140

 gtt ctt cgt gaa cat gaa att gga gag tgg gaa gcc ttc agc ctt cca      480
 Val Leu Arg Glu His Glu Ile Gly Glu Trp Glu Ala Phe Ser Leu Pro
 145                 150                 155                 160

 gaa cta cag aat ttc ttg cgc atc ttg gac aag gaa gaa gat gaa cag      528
 Glu Leu Gln Asn Phe Leu Arg Ile Leu Asp Lys Glu Glu Asp Glu Gln
                 165                 170                 175

 ctg cag aac ctg aag agg cgc tac aca gcc tac agg cag aag ctg gaa      576
 Leu Gln Asn Leu Lys Arg Arg Tyr Thr Ala Tyr Arg Gln Lys Leu Glu
             180                 185                 190

 gaa gcc ctc cgt gag gtg tgg aag cct gat taa agcggggc tccctgcccg      627
 Glu Ala Leu Arg Glu Val Trp Lys Pro Asp 
         195                 200

 tgaggcccgg tgcaggaccg atgtacaaaa cagcagcaag tgcctctctt ctcagagggc    687

 tgctgtcttg ccccactatg ctagggtctt cgcctttcta tctgtagatt ttgttcccca    747

 aacctggtca cacagcatcc tgcaccttag cgtcccatgt aagggactct gcaagcttgt    807

 tgttcagcac cgcagtgtta cctcttggca agctgtgaac ctgtcgcctc atcaggagca    867

 ttcgagggtg cttggaagca tgaactctgg gggtgttttt tttttttggt tattttaatt    927

 atgtgatgat gctgttaagc ttacagatat gcagttgatt ttttaaaaag cttaactagg    987

 aatctttctg aatacttgtc ctattttgaa actacctgtc tggttttttg tttggttttg   1047

 ttttcttttt ttaatgtcag aggaatctat ccatgtgaat cgaaaggcac aggaatctag   1107

 gaactctgag gaatttattg tgaaggattt tgttaggggg ttgacagaga aagcaaagtg   1167

 taagtttgga agaaggcatg tgcggtggtg gcgagcgctg cgggctatgg aaggtgcact   1227

 tggcttttca gttaggggta gtggagaaag gggtagttgc ttgtaaacga gttaaaagca   1287

 ttcagtgtgg aggtgttaaa cccattttag gatcgcttgg tttcctggtg ggtataatat   1347

 gggaacagag ccagaggcag gagctaaacc aaatggaggg acccatgact tatgcagctg   1407

 acc                                                                 1410




      <210> 181
      <211> 1468
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (69)..(1091)

      <400> 181
 gcacgagctc cgagcccgtc cggactcccc cgatcccagc tttctctcct ttgaaaacac     60

 taagaata atg tca ctg cat cag ttt tta cta gag cca atc acc tgt cat     110
          Met Ser Leu His Gln Phe Leu Leu Glu Pro Ile Thr Cys His
            1               5                  10

 gcc tgg aac agg gat cgt act cag att gcc ctc agt ccc aat aat cac      158
 Ala Trp Asn Arg Asp Arg Thr Gln Ile Ala Leu Ser Pro Asn Asn His
  15                  20                  25                  30

 gaa gtg cac atc tat aag aag aac ggg agc cag tgg gtg aaa gct cat      206
 Glu Val His Ile Tyr Lys Lys Asn Gly Ser Gln Trp Val Lys Ala His
                  35                  40                  45

 gaa ctc aag gag cac aac gga cac atc aca ggt att gac tgg gct ccc      254
 Glu Leu Lys Glu His Asn Gly His Ile Thr Gly Ile Asp Trp Ala Pro
              50                  55                  60

 aag agc gac cgc att gtc act tgt ggg gca gac cgc aat gcc tat gtc      302
 Lys Ser Asp Arg Ile Val Thr Cys Gly Ala Asp Arg Asn Ala Tyr Val
          65                  70                  75

 tgg agt cag aaa gat ggt gtc tgg aag cca acc ctg gtg atc ctt aga      350
 Trp Ser Gln Lys Asp Gly Val Trp Lys Pro Thr Leu Val Ile Leu Arg
      80                  85                  90

 att aat cgt gca gct act ttt gtg aag tgg tcc ccg cta gag aac aaa      398
 Ile Asn Arg Ala Ala Thr Phe Val Lys Trp Ser Pro Leu Glu Asn Lys
  95                 100                 105                 110

 ttt gct gtg gga atc ctc agc ttg gat tgg cat ccc aac aat gtt ttg      446
 Phe Ala Val Gly Ile Leu Ser Leu Asp Trp His Pro Asn Asn Val Leu
                 115                 120                 125

 ctg gca gca gga tca tgt gac ttc aaa tgc aga gtg ttt tct gct tac      494
 Leu Ala Ala Gly Ser Cys Asp Phe Lys Cys Arg Val Phe Ser Ala Tyr
             130                 135                 140

 att aaa gaa gtg gat gaa aag cca gcc agc atg ccc tgg ggc agc aag      542
 Ile Lys Glu Val Asp Glu Lys Pro Ala Ser Met Pro Trp Gly Ser Lys
         145                 150                 155

 atg cct ttt ggg cag ctg atg tca gag ttt ggt ggc agt ggc act ggt      590
 Met Pro Phe Gly Gln Leu Met Ser Glu Phe Gly Gly Ser Gly Thr Gly
     160                 165                 170

 ggc tgg gtc cac ggg gta agc ttc tct gcc agt ggg agc cgc ctg gcc      638
 Gly Trp Val His Gly Val Ser Phe Ser Ala Ser Gly Ser Arg Leu Ala
 175                 180                 185                 190

 tgg gtc agc cac gac agc acc gtg tct gtt gct gat gcc tca aaa agt      686
 Trp Val Ser His Asp Ser Thr Val Ser Val Ala Asp Ala Ser Lys Ser
                 195                 200                 205

 gtg cag gtc tcg act ctg aag aca gag ttc ctg ccg ctc cta agt gtg      734
 Val Gln Val Ser Thr Leu Lys Thr Glu Phe Leu Pro Leu Leu Ser Val
             210                 215                 220

 tca ttt gtc tca gag aac agc gtc gtg gct gct ggc cat gac tgc tgc      782
 Ser Phe Val Ser Glu Asn Ser Val Val Ala Ala Gly His Asp Cys Cys
         225                 230                 235

 cca atg ctc ttt aac tac gat gac cgc ggc tgc ctg acc ttc gtc tcc      830
 Pro Met Leu Phe Asn Tyr Asp Asp Arg Gly Cys Leu Thr Phe Val Ser
     240                 245                 250

 aag tta gat att cca aaa cag agc atc caa cgc aac atg tct gcc atg      878
 Lys Leu Asp Ile Pro Lys Gln Ser Ile Gln Arg Asn Met Ser Ala Met
 255                 260                 265                 270

 gaa cgc ttc cgc aac atg gac aag aga gcc aca act gag gac cgc aac      926
 Glu Arg Phe Arg Asn Met Asp Lys Arg Ala Thr Thr Glu Asp Arg Asn
                 275                 280                 285

 acg gcc ttg gag acg ctg cac cag aat agc atc act caa gtc tct att      974
 Thr Ala Leu Glu Thr Leu His Gln Asn Ser Ile Thr Gln Val Ser Ile
             290                 295                 300

 tat gag gtg gac aag caa gat tgt cgc aaa ttt tgc act act ggc atc     1022
 Tyr Glu Val Asp Lys Gln Asp Cys Arg Lys Phe Cys Thr Thr Gly Ile
         305                 310                 315

 gat gga gcc atg aca att tgg gat ttc aag acc ctc gag tct tcc atc     1070
 Asp Gly Ala Met Thr Ile Trp Asp Phe Lys Thr Leu Glu Ser Ser Ile
     320                 325                 330

 cag ggc ctc cgg ata atg tga ag ctgagtgagc ctccgccatc cagcatgaca     1123
 Gln Gly Leu Arg Ile Met 
 335                 340

 aactgtggcc gaccgcagct gtgccgtggc acgatggcga ggaagccagc cccaaggaaa   1183

 cactgaaaac acatatcacg ccaatgccgt gtggttttgt ttgaatataa aattggtgaa   1243

 agtgttggtt tttttaaggc agtaattttt ttgtttgttt ttttgcgatt tcattccatt   1303

 cttgaccaaa gcttctcttt aagtagttta ttatggaaaa ttgtcacact aacttaaaag   1363

 acagggtgag ggagatatgt aaattgtccc ctagaaaatt aaataaaaga actgaatgtg   1423

 gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaatcaaa tggtt                   1468




      <210> 182
      <211> 537
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(537)

      <400> 182
  atg ttg ggg gaa agc aga agt caa gac agc cgc ggg ccc cac acg ccc      48
  Met Leu Gly Glu Ser Arg Ser Gln Asp Ser Arg Gly Pro His Thr Pro
    1               5                  10                  15

 cga ccc gct caa ccg act tgt gct gca gcc atg tct cta gtg atc cct       96
 Arg Pro Ala Gln Pro Thr Cys Ala Ala Ala Met Ser Leu Val Ile Pro
              20                  25                  30

 gaa aag ttc cag cat att ttg cga gta ctc aac acc aac atc gat ggg      144
 Glu Lys Phe Gln His Ile Leu Arg Val Leu Asn Thr Asn Ile Asp Gly
          35                  40                  45

 cgg cgg aaa ata gcc ttt gcc atc act gcc att aag ggt gtg ggc cga      192
 Arg Arg Lys Ile Ala Phe Ala Ile Thr Ala Ile Lys Gly Val Gly Arg
      50                  55                  60

 aga tat gct cat gtg gtg ttg agg aaa gca gac att gac ctc acc aag      240
 Arg Tyr Ala His Val Val Leu Arg Lys Ala Asp Ile Asp Leu Thr Lys
  65                  70                  75                  80

 agg gcg gga gaa ctc act gag gat gag gtg gaa cgt gtg atc acc att      288
 Arg Ala Gly Glu Leu Thr Glu Asp Glu Val Glu Arg Val Ile Thr Ile
                  85                  90                  95

 atg cag aat cca cgc cag tac aag atc cca gac tgg ttc ttg aac aga      336
 Met Gln Asn Pro Arg Gln Tyr Lys Ile Pro Asp Trp Phe Leu Asn Arg
             100                 105                 110

 cag aag gat gta aag gat gga aaa tac agc cag gtc cta gcc aat ggt      384
 Gln Lys Asp Val Lys Asp Gly Lys Tyr Ser Gln Val Leu Ala Asn Gly
         115                 120                 125

 ctg gac aac aag ctc cgt gaa gac ctg gag cga ctg aag aag att cgg      432
 Leu Asp Asn Lys Leu Arg Glu Asp Leu Glu Arg Leu Lys Lys Ile Arg
     130                 135                 140

 gcc cat aga ggg ctg cgt cac ttc tgg ggc ctt cgt gtc cga ggc cag      480
 Ala His Arg Gly Leu Arg His Phe Trp Gly Leu Arg Val Arg Gly Gln
 145                 150                 155                 160

 cac acc aag acc act ggc cgc cgt ggc cgc acc gtg ggt gtg tcc aag      528
 His Thr Lys Thr Thr Gly Arg Arg Gly Arg Thr Val Gly Val Ser Lys
                 165                 170                 175

 aag aaa taa                                                          537
 Lys Lys 






      <210> 183
      <211> 1685
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (143)..(715)

      <400> 183
 cacacgcgcc ctccctccgc gctctgcccc tcgcccgccc gccgcgcacg cagccggccc     60

 cggctcccgg cgccccgcgc ccgcgccccg cgccccgcca ccgccgccgc cgagcaaagc    120

 cgggctgggc ttggagctgc tc atg gag aaa gtg cca ggc gag atg gag atc     172
                          Met Glu Lys Val Pro Gly Glu Met Glu Ile
                            1               5                  10

 gag cgc agg gag cgg agc gag gag ctg tcc gag gcg gag agg aag gcg      220
 Glu Arg Arg Glu Arg Ser Glu Glu Leu Ser Glu Ala Glu Arg Lys Ala
                  15                  20                  25

 gtg cag gct atg tgg gcc cgg ctc tat gcc aac tgc gag gac gtg ggg      268
 Val Gln Ala Met Trp Ala Arg Leu Tyr Ala Asn Cys Glu Asp Val Gly
              30                  35                  40

 gtg gcc atc ctg gtg agg ttc ttt gtg aac ttc ccc tcg gcc aag cag      316
 Val Ala Ile Leu Val Arg Phe Phe Val Asn Phe Pro Ser Ala Lys Gln
          45                  50                  55

 tac ttc agc cag ttc aag cac atg gag gat ccc ctg gag atg gag cgg      364
 Tyr Phe Ser Gln Phe Lys His Met Glu Asp Pro Leu Glu Met Glu Arg
      60                  65                  70

 agc ccc cag ctg cgg aag cac gcc tgc cga gtc atg ggg gcc ctc aac      412
 Ser Pro Gln Leu Arg Lys His Ala Cys Arg Val Met Gly Ala Leu Asn
  75                  80                  85                  90

 act gtc gtg gag aac ctg cat gac ccc gac aag gtg tcc tct gtg ctc      460
 Thr Val Val Glu Asn Leu His Asp Pro Asp Lys Val Ser Ser Val Leu
                  95                 100                 105

 gcc ctt gtg ggg aaa gcc cac gcc ctc aag cac aag gtg gaa ccg gtg      508
 Ala Leu Val Gly Lys Ala His Ala Leu Lys His Lys Val Glu Pro Val
             110                 115                 120

 tac ttc aag atc ctc tct ggg gtc att ctg gag gtg gtc gcc gag gaa      556
 Tyr Phe Lys Ile Leu Ser Gly Val Ile Leu Glu Val Val Ala Glu Glu
         125                 130                 135

 ttt gcc agt gac ttc cca cct gag acg cag aga gcc tgg gcc aag ctg      604
 Phe Ala Ser Asp Phe Pro Pro Glu Thr Gln Arg Ala Trp Ala Lys Leu
     140                 145                 150

 cgt ggc ctc atc tac agc cac gtg acc gct gcc tac aag gaa gtg ggc      652
 Arg Gly Leu Ile Tyr Ser His Val Thr Ala Ala Tyr Lys Glu Val Gly
 155                 160                 165                 170

 tgg gtg cag cag gtc ccc aac gcc acc acc cca ccg gcc aca ctg ccc      700
 Trp Val Gln Gln Val Pro Asn Ala Thr Thr Pro Pro Ala Thr Leu Pro
                 175                 180                 185

 tct tcg ggg ccg tag gacccctaac tccacccccc tccctggcag cacctcgagc      755
 Ser Ser Gly Pro 
             190

 agaaggccga gttctgaaga ccctccttga cgctccattt ctgggtgcca aggaagctgg    815

 aggaatccct gactcaactt ccccgaagga ggcctctgtg gcggccaggg tccccccctg    875

 gagctgctgg gaggcggcgc tggctgcctg gatgctgacc ccagcgcggc gggcagagcg    935

 gggcccactc ttcttagctt ttctactcac tgttagagag agacctagct gagcggctgg    995

 caggaagcgg gacaggtcta ggagtccctt agggaataaa ccagccccgt ttctatcagc   1055

 ccggccagca tgcaggtctc cacatcacca tctagagtat cacgcacaca tctaccatat   1115

 atacagatat attctatata cgagctatat ataaatatat atatacatat atatatacac   1175

 tatatcccta tctagaatgt gttgtcgcgc ggtgacccag aagacgtgcg gtgtggccca   1235

 cctgtgatgt ggggcaggca cggggctccg ggggggagag aacaagaggt gctggcaaag   1295

 aggaatccga cagcgagcgc cagacggcac ggggcctgaa gcggccagag ctggggtaac   1355

 ccggctaggg ggcgagagcc cacgccccct acgtcagaga cagcggccgc cagataccga   1415

 agtggcaacg tgccaggccc aagggagtgg ggaggccgcc tactccgtca gaggaaggac   1475

 tcaccggggt gccttaaact gggcatgggc agaagcgaaa gttctggtgg atgaaccgcg   1535

 ggggaagggc ctcacaccca aaactggacc ggtattccgc tgcgtgcacc aggagcgcag   1595

 gggatcgggc gcggacagcg ccgacaatac tggtccaccc aaccacgggc cggttcccca   1655

 cctcgaggga ggcgcacatg cagcacaggc                                    1685




      <210> 184
      <211> 1998
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (132)..(1859)

      <400> 184
 ctctcacgca gagcttgatt tcataccgga agctagtcac tggcaggaag tttacggaag     60

 aagaaaaaga tttaagtaag tcttccccaa caccgaatgg gattccatct tcagacccag    120

 ccagcgatgc c atg gac ccc ttc cat gct tgc agt att ctt aag caa ctc     170
              Met Asp Pro Phe His Ala Cys Ser Ile Leu Lys Gln Leu
                1               5                  10

 aaa aca atg tac gat gaa gga cag ttg aca gac att gta gtg gaa gtg      218
 Lys Thr Met Tyr Asp Glu Gly Gln Leu Thr Asp Ile Val Val Glu Val
      15                  20                  25

 gat cac ggg aaa aca ttt tcc tgt cat aga aac gtt ctt gct gca atc      266
 Asp His Gly Lys Thr Phe Ser Cys His Arg Asn Val Leu Ala Ala Ile
  30                  35                  40                  45

 agc cct tac ttc aga tcc atg ttc act agc ggc ctt aca gaa agt act      314
 Ser Pro Tyr Phe Arg Ser Met Phe Thr Ser Gly Leu Thr Glu Ser Thr
                  50                  55                  60

 caa aaa gaa gtt cga ata gtt ggt gtt gaa gct gaa tcg atg gat tta      362
 Gln Lys Glu Val Arg Ile Val Gly Val Glu Ala Glu Ser Met Asp Leu
              65                  70                  75

 gtg ttg aac tat gcc tac act tcc aga gtt att ctt aca gag gcc aat      410
 Val Leu Asn Tyr Ala Tyr Thr Ser Arg Val Ile Leu Thr Glu Ala Asn
          80                  85                  90

 gtt caa gcc ttg ttc act gca gct agc atc ttc cag att cct tcc atc      458
 Val Gln Ala Leu Phe Thr Ala Ala Ser Ile Phe Gln Ile Pro Ser Ile
      95                 100                 105

 caa gac caa tgt gct aag tat atg atc agt cat ttg gac cca cag aat      506
 Gln Asp Gln Cys Ala Lys Tyr Met Ile Ser His Leu Asp Pro Gln Asn
 110                 115                 120                 125

 tct att ggg gtc ttt atc ttt gct gat cat tat ggt cat cag gaa ctc      554
 Ser Ile Gly Val Phe Ile Phe Ala Asp His Tyr Gly His Gln Glu Leu
                 130                 135                 140

 gga gat cga tca aaa gaa tac att cgt aaa aag ttt ctg tgt gtc acc      602
 Gly Asp Arg Ser Lys Glu Tyr Ile Arg Lys Lys Phe Leu Cys Val Thr
             145                 150                 155

 aaa gaa caa gag ttt ctc cag ttg aca aaa gac caa ctg ata agt ata      650
 Lys Glu Gln Glu Phe Leu Gln Leu Thr Lys Asp Gln Leu Ile Ser Ile
         160                 165                 170

 cta gac agt gac gat tta aat gta gac cga gaa gag cat gtt tat gaa      698
 Leu Asp Ser Asp Asp Leu Asn Val Asp Arg Glu Glu His Val Tyr Glu
     175                 180                 185

 agc att ata agg tgg ttt gag cat gaa cag aat gaa aga gaa gtg cac      746
 Ser Ile Ile Arg Trp Phe Glu His Glu Gln Asn Glu Arg Glu Val His
 190                 195                 200                 205

 ctt cca gaa att ttt gct aaa tgc ata cgt ttt cct ctg atg gaa gat      794
 Leu Pro Glu Ile Phe Ala Lys Cys Ile Arg Phe Pro Leu Met Glu Asp
                 210                 215                 220

 acc ttt ata gag aaa att cca cct cag ttt gca cag gct ata gcc aaa      842
 Thr Phe Ile Glu Lys Ile Pro Pro Gln Phe Ala Gln Ala Ile Ala Lys
             225                 230                 235

 agc tgt gta gaa aag gga cca tcc aac acc aat ggc tgt aca cag agg      890
 Ser Cys Val Glu Lys Gly Pro Ser Asn Thr Asn Gly Cys Thr Gln Arg
         240                 245                 250

 ctt gga atg act gct tct gaa atg atc ata tgt ttt gat gct gcc cac      938
 Leu Gly Met Thr Ala Ser Glu Met Ile Ile Cys Phe Asp Ala Ala His
     255                 260                 265

 aaa cac tca gga aag aag caa aca gtg cct tgt cta gat ata gtc aca      986
 Lys His Ser Gly Lys Lys Gln Thr Val Pro Cys Leu Asp Ile Val Thr
 270                 275                 280                 285

 gga agg gtg ttt aaa cta tgc aaa cca cca aat gac ctg aga gaa gtt     1034
 Gly Arg Val Phe Lys Leu Cys Lys Pro Pro Asn Asp Leu Arg Glu Val
                 290                 295                 300

 ggg att ctt gta tca cca gat aat gac att tac att gca gga ggg tac     1082
 Gly Ile Leu Val Ser Pro Asp Asn Asp Ile Tyr Ile Ala Gly Gly Tyr
             305                 310                 315

 agg cca agc agc agt gag gtc tcc atc gac cat aag gca gaa aat gat     1130
 Arg Pro Ser Ser Ser Glu Val Ser Ile Asp His Lys Ala Glu Asn Asp
         320                 325                 330

 ttc tgg atg tat gat cat tcc acc aat aga tgg cta tcc aaa cca tcc     1178
 Phe Trp Met Tyr Asp His Ser Thr Asn Arg Trp Leu Ser Lys Pro Ser
     335                 340                 345

 ttg ctt cga gcc aga ata ggc tgc aaa ctt gtc tat tgc tgt ggt aaa     1226
 Leu Leu Arg Ala Arg Ile Gly Cys Lys Leu Val Tyr Cys Cys Gly Lys
 350                 355                 360                 365

 atg tat gca atc gga ggt cgt gtt tat gaa ggt gat ggg aga aac tca     1274
 Met Tyr Ala Ile Gly Gly Arg Val Tyr Glu Gly Asp Gly Arg Asn Ser
                 370                 375                 380

 cta aaa tct gtt gag tgc tac gac agt aga gag aat cgt tgg acg act     1322
 Leu Lys Ser Val Glu Cys Tyr Asp Ser Arg Glu Asn Arg Trp Thr Thr
             385                 390                 395

 gtt tgc gcg atg cca gtt gca atg gaa ttt cat aat gct gtg gag tac     1370
 Val Cys Ala Met Pro Val Ala Met Glu Phe His Asn Ala Val Glu Tyr
         400                 405                 410

 aaa gag aag atc tat gtt tta cag gga gaa ttt ttt ctc ttc tat gag     1418
 Lys Glu Lys Ile Tyr Val Leu Gln Gly Glu Phe Phe Leu Phe Tyr Glu
     415                 420                 425

 cct caa aaa gac tac tgg ggt ttc tta acc ccc atg act gtg cct aga     1466
 Pro Gln Lys Asp Tyr Trp Gly Phe Leu Thr Pro Met Thr Val Pro Arg
 430                 435                 440                 445

 atc cag ggc tta gca gct gta tac aag gac tct atc tac tac ata gct     1514
 Ile Gln Gly Leu Ala Ala Val Tyr Lys Asp Ser Ile Tyr Tyr Ile Ala
                 450                 455                 460

 gga acc tgt gga aat cat caa cgt atg ttt act gta gaa gcc tat gat     1562
 Gly Thr Cys Gly Asn His Gln Arg Met Phe Thr Val Glu Ala Tyr Asp
             465                 470                 475

 att gag cta aat aaa tgg act cgt aag aaa gac ttt cca tgt gat cag     1610
 Ile Glu Leu Asn Lys Trp Thr Arg Lys Lys Asp Phe Pro Cys Asp Gln
         480                 485                 490

 tcc ata aat cca tac ctt aaa ctg gta ctt ttc cag aac aaa ctc cat     1658
 Ser Ile Asn Pro Tyr Leu Lys Leu Val Leu Phe Gln Asn Lys Leu His
     495                 500                 505

 tta ttt gtt cga gct act caa gtg act gtt gaa gaa cac gtc ttc aga     1706
 Leu Phe Val Arg Ala Thr Gln Val Thr Val Glu Glu His Val Phe Arg
 510                 515                 520                 525

 acc agc aga aaa aat tcc ctt tac caa tat gat gac att gct gac cag     1754
 Thr Ser Arg Lys Asn Ser Leu Tyr Gln Tyr Asp Asp Ile Ala Asp Gln
                 530                 535                 540

 tgg atg aaa gtg tat gag acc cca gat cgg ctc tgg gac ctt ggc cgg     1802
 Trp Met Lys Val Tyr Glu Thr Pro Asp Arg Leu Trp Asp Leu Gly Arg
             545                 550                 555

 cat ttt gaa tgt gct gtt gct aaa ctg tat cct cag tgt ctt cag aaa     1850
 His Phe Glu Cys Ala Val Ala Lys Leu Tyr Pro Gln Cys Leu Gln Lys
         560                 565                 570

 gta ctc taa atgagta gcaggcctta gtgcatcact ggcatctcat tcttaggaaa     1906
 Val Leu 
     575

 cttgtctttg atacaaaaga gtgctgacat ttcatttcag taaggaaaag ataacaaagt   1966

 gcaattatca gcattttttt tttcctggca ta                                 1998




      <210> 185
      <211> 1224
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1224)

      <400> 185
  atg gag ggg ccg gca gag tgg ggc ccc gag gcg gcg ctg ggc ccc gag      48
  Met Glu Gly Pro Ala Glu Trp Gly Pro Glu Ala Ala Leu Gly Pro Glu
    1               5                  10                  15

 gcg gtg ctg cgc ttc ctg gcg gag cgc ggg ggc cgg gcc ctg cac gcc       96
 Ala Val Leu Arg Phe Leu Ala Glu Arg Gly Gly Arg Ala Leu His Ala
              20                  25                  30

 gag ctg gtg cag cac ttc agg ggc gcc ctg ggc ggc gaa ccg gag cag      144
 Glu Leu Val Gln His Phe Arg Gly Ala Leu Gly Gly Glu Pro Glu Gln
          35                  40                  45

 cgc gcc cgc gcc cgc gcg cac ttc aag gag ctg gtg aac gcc gtg gcc      192
 Arg Ala Arg Ala Arg Ala His Phe Lys Glu Leu Val Asn Ala Val Ala
      50                  55                  60

 act gtg cgc gtc gat ccc gcc gac ggc gcc aag tac gtg cac ctc aag      240
 Thr Val Arg Val Asp Pro Ala Asp Gly Ala Lys Tyr Val His Leu Lys
  65                  70                  75                  80

 aag agg ttc tgt gaa ggg ccg tcc gag ccc tcc ggg gac ccg ccg cga      288
 Lys Arg Phe Cys Glu Gly Pro Ser Glu Pro Ser Gly Asp Pro Pro Arg
                  85                  90                  95

 atc cag gtg acc gcc gag ccc gag gcc ccc gac ggc cct gcc ggg ccc      336
 Ile Gln Val Thr Ala Glu Pro Glu Ala Pro Asp Gly Pro Ala Gly Pro
             100                 105                 110

 gag gcg cgc gat cgg ctc ccc gac gcg gcg gcc ccg gag tcg ctc cct      384
 Glu Ala Arg Asp Arg Leu Pro Asp Ala Ala Ala Pro Glu Ser Leu Pro
         115                 120                 125

 gga cag ggc cgc gag ctg ggc gag gga gag ccc ccc gcc ccc gcg cac      432
 Gly Gln Gly Arg Glu Leu Gly Glu Gly Glu Pro Pro Ala Pro Ala His
     130                 135                 140

 tgg ccg ccc ctg agc gcc ggg gct cgc agg aag aac tcg cgg cgc gac      480
 Trp Pro Pro Leu Ser Ala Gly Ala Arg Arg Lys Asn Ser Arg Arg Asp
 145                 150                 155                 160

 gtg cag ccc cta ccg cgg act cca gcc ccg ggg ccc agc gag gac ctg      528
 Val Gln Pro Leu Pro Arg Thr Pro Ala Pro Gly Pro Ser Glu Asp Leu
                 165                 170                 175

 gag ctc ccg cca cat ggc tgc gag gag gcg gac agg ggc agc tcc ctt      576
 Glu Leu Pro Pro His Gly Cys Glu Glu Ala Asp Arg Gly Ser Ser Leu
             180                 185                 190

 gtg ggg gct acc gca cag agg ccg gcc cgc cag aac ctc cgt gac ctg      624
 Val Gly Ala Thr Ala Gln Arg Pro Ala Arg Gln Asn Leu Arg Asp Leu
         195                 200                 205

 gtg atg ggc agc tcc ccg cag ctg aag agg agc gtg tgt ccc ggg ggc      672
 Val Met Gly Ser Ser Pro Gln Leu Lys Arg Ser Val Cys Pro Gly Gly
     210                 215                 220

 agc agc ccg ggc agc tcc tcc ggg gga gga cgc ggc aga ggc ggg ggc      720
 Ser Ser Pro Gly Ser Ser Ser Gly Gly Gly Arg Gly Arg Gly Gly Gly
 225                 230                 235                 240

 gac tca gac agc gca tcg gtg gcc tcg tcg tcc gcg gag gag gag agc      768
 Asp Ser Asp Ser Ala Ser Val Ala Ser Ser Ser Ala Glu Glu Glu Ser
                 245                 250                 255

 agc ggc gga ggc tcc gtg acg ctg gac ccc ctg gag cac gcg tgg atg      816
 Ser Gly Gly Gly Ser Val Thr Leu Asp Pro Leu Glu His Ala Trp Met
             260                 265                 270

 ctc tct gcc tcc gat ggc aag tgg gac agc ctg gag gct ccc ggt gaa      864
 Leu Ser Ala Ser Asp Gly Lys Trp Asp Ser Leu Glu Ala Pro Gly Glu
         275                 280                 285

 cat cga cgc cag gac gag cgg ggt tac acc gcc ctg cac ttg gca gcc      912
 His Arg Arg Gln Asp Glu Arg Gly Tyr Thr Ala Leu His Leu Ala Ala
     290                 295                 300

 atg cac ggc cac gtg gag gtg gtg aag ctg ctg gtg ggg gcc tac gac      960
 Met His Gly His Val Glu Val Val Lys Leu Leu Val Gly Ala Tyr Asp
 305                 310                 315                 320

 gcc gat gtg gac atc agg gac tac agt ggg aaa aag gcc tcc cag tac     1008
 Ala Asp Val Asp Ile Arg Asp Tyr Ser Gly Lys Lys Ala Ser Gln Tyr
                 325                 330                 335

 ctg agt cgg agc atc gcc gag gag atc aag aac ctg gtg gga gcc ctg     1056
 Leu Ser Arg Ser Ile Ala Glu Glu Ile Lys Asn Leu Val Gly Ala Leu
             340                 345                 350

 gac gag ggt gac ggg gaa agg ccg cgg gta gcg gcg gcg ggc gct gga     1104
 Asp Glu Gly Asp Gly Glu Arg Pro Arg Val Ala Ala Ala Gly Ala Gly
         355                 360                 365

 ggc ttt caa aga ggc ttt cag aag tca gat gaa caa gat gat ggc gat     1152
 Gly Phe Gln Arg Gly Phe Gln Lys Ser Asp Glu Gln Asp Asp Gly Asp
     370                 375                 380

 gat gat tcc tgc tac tcc ctg ccc cag ctt gct tca tgg tct gtg tac     1200
 Asp Asp Ser Cys Tyr Ser Leu Pro Gln Leu Ala Ser Trp Ser Val Tyr
 385                 390                 395                 400

 aaa atg gcc cta gca atg aga tga                                     1224
 Lys Met Ala Leu Ala Met Arg 
                 405





      <210> 186
      <211> 879
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(879)

      <400> 186
  atg aga gag agt gac aat cca ggc aca ggg cca tgg gtg acc acg gtg      48
  Met Arg Glu Ser Asp Asn Pro Gly Thr Gly Pro Trp Val Thr Thr Val
    1               5                  10                  15

 gcc gcc ggg aac cag ccc acc ctg att gca cac tcc tat gga gtg gcc       96
 Ala Ala Gly Asn Gln Pro Thr Leu Ile Ala His Ser Tyr Gly Val Ala
              20                  25                  30

 cag cct ccc acc ttc agc ccg gct gtg aac gtc cag gcc ccg gtc att      144
 Gln Pro Pro Thr Phe Ser Pro Ala Val Asn Val Gln Ala Pro Val Ile
          35                  40                  45

 ggg gtg acc ccc tca ctg cct ccc cac gtg ggg ccc cag ctc ccg ctg      192
 Gly Val Thr Pro Ser Leu Pro Pro His Val Gly Pro Gln Leu Pro Leu
      50                  55                  60

 atg cca ggc cac tac tcg ctc cct cag ccg ccc tct cag cca ctg agc      240
 Met Pro Gly His Tyr Ser Leu Pro Gln Pro Pro Ser Gln Pro Leu Ser
  65                  70                  75                  80

 agc gtg gtg gtc aac atg cct gcc cag gcc ctg tat gcc agc cct cag      288
 Ser Val Val Val Asn Met Pro Ala Gln Ala Leu Tyr Ala Ser Pro Gln
                  85                  90                  95

 ccc ctg gcc gtg tcc aca ctg ccc ggt gtg ggg cag gtg gcc cgc cca      336
 Pro Leu Ala Val Ser Thr Leu Pro Gly Val Gly Gln Val Ala Arg Pro
             100                 105                 110

 gga ccc acc gct gtg ggc aac ggc cac atg gca ggg ccc ctg ctg cct      384
 Gly Pro Thr Ala Val Gly Asn Gly His Met Ala Gly Pro Leu Leu Pro
         115                 120                 125

 cca ccg ccg cca gcc cag ccg tcc gcc act ctc ccc agt ggt gcc cct      432
 Pro Pro Pro Pro Ala Gln Pro Ser Ala Thr Leu Pro Ser Gly Ala Pro
     130                 135                 140

 gcc acc aat ggg ccc ccc aca acc gac tcg gcc cac ggg ctg cag atg      480
 Ala Thr Asn Gly Pro Pro Thr Thr Asp Ser Ala His Gly Leu Gln Met
 145                 150                 155                 160

 ctg cgg acc att ggc gtg ggg aag tat gag ttc acc gac ccg ggg cac      528
 Leu Arg Thr Ile Gly Val Gly Lys Tyr Glu Phe Thr Asp Pro Gly His
                 165                 170                 175

 ccc aga ggt aag tcc tgc tgc cac gtg cct ccc cac ggg cct gcg tct      576
 Pro Arg Gly Lys Ser Cys Cys His Val Pro Pro His Gly Pro Ala Ser
             180                 185                 190

 gca cct ccc tgc gcg gtc act gca aca cca ccg gga cag ggg gtg ctt      624
 Ala Pro Pro Cys Ala Val Thr Ala Thr Pro Pro Gly Gln Gly Val Leu
         195                 200                 205

 cat gcc agc tcc ttc act ggc ctc ccc aac cca gag gct gca gtg gag      672
 His Ala Ser Ser Phe Thr Gly Leu Pro Asn Pro Glu Ala Ala Val Glu
     210                 215                 220

 cct cca cct gcc caa gac aac tgg cct gag atg ggg gag gga ggg gga      720
 Pro Pro Pro Ala Gln Asp Asn Trp Pro Glu Met Gly Glu Gly Gly Gly
 225                 230                 235                 240

 agg tgt gga ggg cgg gac aaa caa agt ggg aaa atg cgc cgg ggt aag      768
 Arg Cys Gly Gly Arg Asp Lys Gln Ser Gly Lys Met Arg Arg Gly Lys
                 245                 250                 255

 aag agg aag gaa ggg aga gcc tgc aaa gcc cag agc ccg tcc ccc tcc      816
 Lys Arg Lys Glu Gly Arg Ala Cys Lys Ala Gln Ser Pro Ser Pro Ser
             260                 265                 270

 agc cca agc cct ggc cat tct cac ctc caa ccc cca agg cca ggc caa      864
 Ser Pro Ser Pro Gly His Ser His Leu Gln Pro Pro Arg Pro Gly Gln
         275                 280                 285

 gct gca aaa ggg tga                                                  879
 Ala Ala Lys Gly 
     290





      <210> 187
      <211> 1407
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1407)

      <400> 187
  atg tac cgc tac ctg ggc gaa gcg ctg ttg ctg tcc cgg gcc ggg ccc      48
  Met Tyr Arg Tyr Leu Gly Glu Ala Leu Leu Leu Ser Arg Ala Gly Pro
    1               5                  10                  15

 gct gcc ctg ggc tcg gcg tcc gcc gac tcg gcc gcg ttg ctg ggc tgg       96
 Ala Ala Leu Gly Ser Ala Ser Ala Asp Ser Ala Ala Leu Leu Gly Trp
              20                  25                  30

 gcc cgg gga cag ccc gcc gcc gcc ccg cag ccg ggg ctg gca ttg gcc      144
 Ala Arg Gly Gln Pro Ala Ala Ala Pro Gln Pro Gly Leu Ala Leu Ala
          35                  40                  45

 gcc cgg cgc cac tac agc gag gcg gtg gcc gac cgc gag gac gac ccc      192
 Ala Arg Arg His Tyr Ser Glu Ala Val Ala Asp Arg Glu Asp Asp Pro
      50                  55                  60

 aac ttc ttc aag atg gtg gag ggc ttc ttc gat cgc ggc gcc agc atc      240
 Asn Phe Phe Lys Met Val Glu Gly Phe Phe Asp Arg Gly Ala Ser Ile
  65                  70                  75                  80

 gtg gag gac aag ctg gtg gag gac ctg agg acc cgg gag agc gag gag      288
 Val Glu Asp Lys Leu Val Glu Asp Leu Arg Thr Arg Glu Ser Glu Glu
                  85                  90                  95

 cag aag cgg aac cgg tta cta cat gta cct gag gcc gtt aga ttt gtc      336
 Gln Lys Arg Asn Arg Leu Leu His Val Pro Glu Ala Val Arg Phe Val
             100                 105                 110

 tgt gtt aag gat ttg aaa ggc act gat gtg agt gta gat gaa gta aaa      384
 Cys Val Lys Asp Leu Lys Gly Thr Asp Val Ser Val Asp Glu Val Lys
         115                 120                 125

 gct ttg gct tct ctg atg aca tac aag tgt gca gtg gtt gat gtg ccg      432
 Ala Leu Ala Ser Leu Met Thr Tyr Lys Cys Ala Val Val Asp Val Pro
     130                 135                 140

 ttt ggg ggt gct aaa gct ggt gtt aag atc aat ccc aag aac tat act      480
 Phe Gly Gly Ala Lys Ala Gly Val Lys Ile Asn Pro Lys Asn Tyr Thr
 145                 150                 155                 160

 gat aat gaa ttg gaa aag atc aca agg agg ttc acc atg gag cta gca      528
 Asp Asn Glu Leu Glu Lys Ile Thr Arg Arg Phe Thr Met Glu Leu Ala
                 165                 170                 175

 aaa aag ggc ttt att ggt cct ggc att gat gtg cct gct cca gac atg      576
 Lys Lys Gly Phe Ile Gly Pro Gly Ile Asp Val Pro Ala Pro Asp Met
             180                 185                 190

 agc aca ggt gag cgg gag atg tcc tgg atc gct gat acc tat gcc agc      624
 Ser Thr Gly Glu Arg Glu Met Ser Trp Ile Ala Asp Thr Tyr Ala Ser
         195                 200                 205

 acc ata ggg cac tat gat att aat gca cac gcc tgt gtt act ggt aaa      672
 Thr Ile Gly His Tyr Asp Ile Asn Ala His Ala Cys Val Thr Gly Lys
     210                 215                 220

 ccc atc agc caa ggg gga atc cat gga cgc atc tct gct act ggc cgt      720
 Pro Ile Ser Gln Gly Gly Ile His Gly Arg Ile Ser Ala Thr Gly Arg
 225                 230                 235                 240

 ggt gtc ttc cat ggg att gaa aat ttc atc aat gaa gct tct tac atg      768
 Gly Val Phe His Gly Ile Glu Asn Phe Ile Asn Glu Ala Ser Tyr Met
                 245                 250                 255

 agc att tta gga atg aca cca ggg ttt gga gat aaa aca ttt gtt gtt      816
 Ser Ile Leu Gly Met Thr Pro Gly Phe Gly Asp Lys Thr Phe Val Val
             260                 265                 270

 cag gca aag ccc tat gaa gga agc atc ttg gag gcc gac tgt gac ata      864
 Gln Ala Lys Pro Tyr Glu Gly Ser Ile Leu Glu Ala Asp Cys Asp Ile
         275                 280                 285

 ctg atc cca gct gcc agt gag aag cag ttg acc aaa tcc aac gca ccc      912
 Leu Ile Pro Ala Ala Ser Glu Lys Gln Leu Thr Lys Ser Asn Ala Pro
     290                 295                 300

 aga gtc aaa gcc aag atc att gct gaa ggt gcc aat ggg cca aca act      960
 Arg Val Lys Ala Lys Ile Ile Ala Glu Gly Ala Asn Gly Pro Thr Thr
 305                 310                 315                 320

 cca gaa gct gac aag atc ttc ctg gag aga aac att atg gtt att cca     1008
 Pro Glu Ala Asp Lys Ile Phe Leu Glu Arg Asn Ile Met Val Ile Pro
                 325                 330                 335

 gat ctc tac ttg aat gct gga gga gtg aca gta tct tac ttt gag tgg     1056
 Asp Leu Tyr Leu Asn Ala Gly Gly Val Thr Val Ser Tyr Phe Glu Trp
             340                 345                 350

 ctg aag aat cta aat cat gtc agc tat ggc cgt ttg acc ttc aaa tat     1104
 Leu Lys Asn Leu Asn His Val Ser Tyr Gly Arg Leu Thr Phe Lys Tyr
         355                 360                 365

 gaa agg gat tct aac tac cac ttg ctc atg tct gtt caa gag agt tta     1152
 Glu Arg Asp Ser Asn Tyr His Leu Leu Met Ser Val Gln Glu Ser Leu
     370                 375                 380

 gaa aga aaa ttt gga aag cat ggt gga act att ccc att gta ccc acg     1200
 Glu Arg Lys Phe Gly Lys His Gly Gly Thr Ile Pro Ile Val Pro Thr
 385                 390                 395                 400

 gca gag ttc caa gac agg ata tcg ggt gca tct gag aaa gac atc gtg     1248
 Ala Glu Phe Gln Asp Arg Ile Ser Gly Ala Ser Glu Lys Asp Ile Val
                 405                 410                 415

 cac tct ggc ttg gca tac aca atg gag cgt tct gcc agg caa att atg     1296
 His Ser Gly Leu Ala Tyr Thr Met Glu Arg Ser Ala Arg Gln Ile Met
             420                 425                 430

 cgc aca gcc atg aag tat aac ctg gga ttg gac ctg aga aca gct gcc     1344
 Arg Thr Ala Met Lys Tyr Asn Leu Gly Leu Asp Leu Arg Thr Ala Ala
         435                 440                 445

 tat gtt aat gcc att gag aaa gtc ttc aaa gtg tac aat gaa gct ggt     1392
 Tyr Val Asn Ala Ile Glu Lys Val Phe Lys Val Tyr Asn Glu Ala Gly
     450                 455                 460

 gtg acc ttc aca tag                                                 1407
 Val Thr Phe Thr 
 465





      <210> 188
      <211> 547
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (84)..(524)

      <400> 188
 ttcaacaccc accttcgtga taaaactaaa aaatcggaca gtctgtaagt aaaatacagg     60

 gacactttac taccctgaaa atc    atg ctg ggt tcc cgc tac gcc ggg cag     110
                              Met Leu Gly Ser Arg Tyr Ala Gly Gln
                                1               5

 acg ttt tca gga gca tca ccg cgc ggc gtc tcg gac gca ctt ctc ctg      158
 Thr Phe Ser Gly Ala Ser Pro Arg Gly Val Ser Asp Ala Leu Leu Leu
  10                  15                  20                  25

 gcg ccc tcc ggg cgg cag cgc tct cga gac act gtt gct tcg ccg tca      206
 Ala Pro Ser Gly Arg Gln Arg Ser Arg Asp Thr Val Ala Ser Pro Ser
                  30                  35                  40

 cgc ccg tcg ttg tca cgc cct tcc ccg cgg aca ccg aga atg acc cat      254
 Arg Pro Ser Leu Ser Arg Pro Ser Pro Arg Thr Pro Arg Met Thr His
              45                  50                  55

 agc gga aaa ttc tac cgc act acc tcc ctg agg cag cga ccg gta aga      302
 Ser Gly Lys Phe Tyr Arg Thr Thr Ser Leu Arg Gln Arg Pro Val Arg
          60                  65                  70

 aac aac ctt ttc ttc agg ctt ccc acc acc caa aca cag tcg cag tca      350
 Asn Asn Leu Phe Phe Arg Leu Pro Thr Thr Gln Thr Gln Ser Gln Ser
      75                  80                  85

 act ggc cac tat cac cca cca ccc tgc agg aac aat tac cca gcc tca      398
 Thr Gly His Tyr His Pro Pro Pro Cys Arg Asn Asn Tyr Pro Ala Ser
  90                  95                 100                 105

 ccc caa gaa cgc gcg gag agg agg tgc caa aag aaa ttc tgt tct cgc      446
 Pro Gln Glu Arg Ala Glu Arg Arg Cys Gln Lys Lys Phe Cys Ser Arg
                 110                 115                 120

 gaa gtc tta aac tta atc cta gcg gcg tct ctg aac ctg tcg ttc ttt      494
 Glu Val Leu Asn Leu Ile Leu Ala Ala Ser Leu Asn Leu Ser Phe Phe
             125                 130                 135

 ctc aga aga aat cgt cgt ccc ggg aaa taa a ggccggttgc ttatacgtac      545
 Leu Arg Arg Asn Arg Arg Pro Gly Lys 
         140                 145

 gt                                                                   547




      <210> 189
      <211> 650
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (103)..(627)

      <400> 189
 agtttatcat gacatttgag tatcatctga acaaacatac attggtcgtc caaagagaat     60

 taaaaattgt cagaaaagtc tgaacaatga agcaaatgta gc   atg agg atc gcc     114
                                                  Met Arg Ile Ala
                                                    1

 atg aaa ggt gta ccg gaa ggt acc tcc ttg tcc atc agt acc tcc tgc      162
 Met Lys Gly Val Pro Glu Gly Thr Ser Leu Ser Ile Ser Thr Ser Cys
   5                  10                  15                  20

 tcc tcc ttt caa ccc ctg aaa atc atg ctg ggt tcc cgc tac gcc ggg      210
 Ser Ser Phe Gln Pro Leu Lys Ile Met Leu Gly Ser Arg Tyr Ala Gly
                  25                  30                  35

 cag acg ttt tca gga gca tca ccg cgc ggc gtc tcg gac gca ctt ctc      258
 Gln Thr Phe Ser Gly Ala Ser Pro Arg Gly Val Ser Asp Ala Leu Leu
              40                  45                  50

 ctg gcg ccc tcc ggg cgg cag cgc tct cga gac act gtt gct tcg ccg      306
 Leu Ala Pro Ser Gly Arg Gln Arg Ser Arg Asp Thr Val Ala Ser Pro
          55                  60                  65

 tca cgc ccg tcg ttg tca cgc cct tcc ccg cgg aca ccg aga atg acc      354
 Ser Arg Pro Ser Leu Ser Arg Pro Ser Pro Arg Thr Pro Arg Met Thr
      70                  75                  80

 cat agc gga aaa ttc tac cgc act acc tcc ctg agg cag cga ccg gta      402
 His Ser Gly Lys Phe Tyr Arg Thr Thr Ser Leu Arg Gln Arg Pro Val
  85                  90                  95                 100

 aga aac aac ctt ttc ttc agg ctt ccc acc acc caa aca cag tcg cag      450
 Arg Asn Asn Leu Phe Phe Arg Leu Pro Thr Thr Gln Thr Gln Ser Gln
                 105                 110                 115

 tca act ggc cac tat cac cca cca ccc tgc agg aac aat tac cca gcc      498
 Ser Thr Gly His Tyr His Pro Pro Pro Cys Arg Asn Asn Tyr Pro Ala
             120                 125                 130

 tca ccc caa gaa cgc gcg gag agg agg tgc caa aag aaa ttc tgt tct      546
 Ser Pro Gln Glu Arg Ala Glu Arg Arg Cys Gln Lys Lys Phe Cys Ser
         135                 140                 145

 cgc gaa gtc tta aac tta atc cta gcg gcg tct ctg aac ctg tcg ttc      594
 Arg Glu Val Leu Asn Leu Ile Leu Ala Ala Ser Leu Asn Leu Ser Phe
     150                 155                 160

 ttt ctc aga aga aat cgt cgt ccc ggg aaa taa aggccggt tgcttatacg      645
 Phe Leu Arg Arg Asn Arg Arg Pro Gly Lys 
 165                 170

 tacgt                                                                650




      <210> 190
      <211> 772
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (28)..(528)

      <400> 190
 gtggcgactc tgcgtccccg gctcctg    atg gag gcg ggg ccg cat ccc cgg      51
                                  Met Glu Ala Gly Pro His Pro Arg
                                    1               5

 ccg ggg cac tgc tgc aag cct ggg ggg cgg ctg gac atg aac cac ggc       99
 Pro Gly His Cys Cys Lys Pro Gly Gly Arg Leu Asp Met Asn His Gly
      10                  15                  20

 ttc gtg cac cat atc cga cgg aac cag atc gct cgg gac gac tat gac      147
 Phe Val His His Ile Arg Arg Asn Gln Ile Ala Arg Asp Asp Tyr Asp
  25                  30                  35                  40

 aag aag gtg aag cag gcg gcc aag gag aag gtg agg agg cgg cac acg      195
 Lys Lys Val Lys Gln Ala Ala Lys Glu Lys Val Arg Arg Arg His Thr
                  45                  50                  55

 ccc gcg ccg acg cgg ccc cgc aag cca gac ctg cag gtg tac ctg ccg      243
 Pro Ala Pro Thr Arg Pro Arg Lys Pro Asp Leu Gln Val Tyr Leu Pro
              60                  65                  70

 cga cac cga gat gtc tct gcc cac cca cgc aac cca gac tat gaa gag      291
 Arg His Arg Asp Val Ser Ala His Pro Arg Asn Pro Asp Tyr Glu Glu
          75                  80                  85

 tcc ggt gaa agc agc agt agt gga ggc tct gag ctg gag cct tct ggc      339
 Ser Gly Glu Ser Ser Ser Ser Gly Gly Ser Glu Leu Glu Pro Ser Gly
      90                  95                 100

 cat cag ctc ttc tgc tta gaa tac gag gca gac agt gga gag gtc aca      387
 His Gln Leu Phe Cys Leu Glu Tyr Glu Ala Asp Ser Gly Glu Val Thr
 105                 110                 115                 120

 tca gtt atc gtc tat cag ggt gat gac cca gga aag gtg agt gag aag      435
 Ser Val Ile Val Tyr Gln Gly Asp Asp Pro Gly Lys Val Ser Glu Lys
                 125                 130                 135

 gtg tcg gca cac acg cct ctg gat cca ccc atg cga gaa gcc ctc aag      483
 Val Ser Ala His Thr Pro Leu Asp Pro Pro Met Arg Glu Ala Leu Lys
             140                 145                 150

 ttg cgt atc cag gag gag att gca aag cgc cag agc caa cac tga cca      531
 Leu Arg Ile Gln Glu Glu Ile Ala Lys Arg Gln Ser Gln His 
         155                 160                 165

 tgttgaaggc gttctctcca ggctggattc actgcactcg gaagaattct gcccagggaa    591

 tttagtgtgg gggtaccagg accagtttgt ctgatcttga gacccccaga gctgctgcat    651

 ccatagggtg ttgcaggact acacctggcc tgccttgcag tcattctttc ttatatgttg    711

 acccatttgc ccagcctgat attctggaat tctttttttt tttttttttt ttggaaacaa    771

 a                                                                    772




      <210> 191
      <211> 930
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(681)

      <400> 191
  atg gcc gcg ccg gcc ccg gtc acg cgg cag gtt agc ggc gcc gcc gcc      48
  Met Ala Ala Pro Ala Pro Val Thr Arg Gln Val Ser Gly Ala Ala Ala
    1               5                  10                  15

 ctg gtc ccg gcc ccg agc ggc ccc gac agc ggg cag ccc ctg gcg gcc       96
 Leu Val Pro Ala Pro Ser Gly Pro Asp Ser Gly Gln Pro Leu Ala Ala
              20                  25                  30

 gcc gtg gcc gag ctg ccg gtg ctg gac gcc cgc ggg cag cgg gta ccg      144
 Ala Val Ala Glu Leu Pro Val Leu Asp Ala Arg Gly Gln Arg Val Pro
          35                  40                  45

 ttc ggc gcg ctg ttc cgg gag cgc cgc gcc gtg gtg gtg ttc gtg cgg      192
 Phe Gly Ala Leu Phe Arg Glu Arg Arg Ala Val Val Val Phe Val Arg
      50                  55                  60

 cat ttc ctg tgt tac atc tgc aag gaa tac gta gag gat ctg gcc aaa      240
 His Phe Leu Cys Tyr Ile Cys Lys Glu Tyr Val Glu Asp Leu Ala Lys
  65                  70                  75                  80

 atc ccc agg agt ttc tta caa gaa gca aat gtc acc ctt ata gtg att      288
 Ile Pro Arg Ser Phe Leu Gln Glu Ala Asn Val Thr Leu Ile Val Ile
                  85                  90                  95

 gga cag tca tcc tac cat cat att gag cct ttt tgc aag ctg act gga      336
 Gly Gln Ser Ser Tyr His His Ile Glu Pro Phe Cys Lys Leu Thr Gly
             100                 105                 110

 tat tct cat gaa atc tat gtc gat cct gag aga gaa att tat aaa aga      384
 Tyr Ser His Glu Ile Tyr Val Asp Pro Glu Arg Glu Ile Tyr Lys Arg
         115                 120                 125

 ttg gga atg aaa aga ggt gaa gaa att gct tcc tca gga cag agc ccc      432
 Leu Gly Met Lys Arg Gly Glu Glu Ile Ala Ser Ser Gly Gln Ser Pro
     130                 135                 140

 cac ata aaa tca aat cta ctc tca gga agc ctt cag agc ctg tgg cgg      480
 His Ile Lys Ser Asn Leu Leu Ser Gly Ser Leu Gln Ser Leu Trp Arg
 145                 150                 155                 160

 gca gtg act ggc cct ctc ttt gat ttt caa gga gac cca gct cag caa      528
 Ala Val Thr Gly Pro Leu Phe Asp Phe Gln Gly Asp Pro Ala Gln Gln
                 165                 170                 175

 ggt gga acc ctc att tta ggt cca ggt aac aac atc cat ttt ata cac      576
 Gly Gly Thr Leu Ile Leu Gly Pro Gly Asn Asn Ile His Phe Ile His
             180                 185                 190

 cgc gat agg aat agg ttg gat cac aaa cct atc aac tct gtt tta cag      624
 Arg Asp Arg Asn Arg Leu Asp His Lys Pro Ile Asn Ser Val Leu Gln
         195                 200                 205

 ctt gta gga gtt cag cat gtg aac ttt aca aac aga cct tca gtt atc      672
 Leu Val Gly Val Gln His Val Asn Phe Thr Asn Arg Pro Ser Val Ile
     210                 215                 220

 cat gtg tga cttaaaa tgcactcagt cactttcaac tggaccttct ggaatgtgac      728
 His Val 
 225

 cttcaatgcc tgggtgtaat atcctcgtgc agtgtctaac ctgctgtccc ttcccagcct    788

 ttgaggagtt agggaagcat aaagggggct tgaacctgtt gaattgcatg ctgggaagca    848

 tcagttgtca aaatatgtta tatacttcca ttttataact tttaacattt tatacaaaaa    908

 aaaaaaaaaa aaaaaaagat tt                                             930




      <210> 192
      <211> 558
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(558)

      <400> 192
  atg gcc gcg ccg gcc ccg gtc acg cgg cag gtt agc ggc gcc gcc gcc      48
  Met Ala Ala Pro Ala Pro Val Thr Arg Gln Val Ser Gly Ala Ala Ala
    1               5                  10                  15

 ctg gtc ccg gcc ccg agc ggc ccc gac agc ggg cag ccc ctg gcg gcc       96
 Leu Val Pro Ala Pro Ser Gly Pro Asp Ser Gly Gln Pro Leu Ala Ala
              20                  25                  30

 gcc gtg gcc gag ctg ccg gtg ctg gac gcc cgc ggg cag cgg gta ccg      144
 Ala Val Ala Glu Leu Pro Val Leu Asp Ala Arg Gly Gln Arg Val Pro
          35                  40                  45

 ttc ggc gcg ctg ttc cgg gag cgc cgc gcc gtg gtg gtg ttc gtg cgg      192
 Phe Gly Ala Leu Phe Arg Glu Arg Arg Ala Val Val Val Phe Val Arg
      50                  55                  60

 cct ttt tgc aag ctg act gga tat tct cat gaa atc tat gtc gat cct      240
 Pro Phe Cys Lys Leu Thr Gly Tyr Ser His Glu Ile Tyr Val Asp Pro
  65                  70                  75                  80

 gag aga gaa att tat aaa aga ttg gga atg aaa aga ggt gaa gaa att      288
 Glu Arg Glu Ile Tyr Lys Arg Leu Gly Met Lys Arg Gly Glu Glu Ile
                  85                  90                  95

 gct tcc tca gga cag agc ccc cac ata aaa tca aat cta ctc tca gga      336
 Ala Ser Ser Gly Gln Ser Pro His Ile Lys Ser Asn Leu Leu Ser Gly
             100                 105                 110

 agc ctt cag agc ctg tgg cgg gca gtg act ggc cct ctc ttt gat ttt      384
 Ser Leu Gln Ser Leu Trp Arg Ala Val Thr Gly Pro Leu Phe Asp Phe
         115                 120                 125

 caa gga gac cca gct cag caa ggt gga acc ctc att tta ggt cca ggt      432
 Gln Gly Asp Pro Ala Gln Gln Gly Gly Thr Leu Ile Leu Gly Pro Gly
     130                 135                 140

 aac aac atc cat ttt ata cac cgc gat agg aat agg ttg gat cac aaa      480
 Asn Asn Ile His Phe Ile His Arg Asp Arg Asn Arg Leu Asp His Lys
 145                 150                 155                 160

 cct atc aac tct gtt tta cag ctt gta gga gtt cag cat gtg aac ttt      528
 Pro Ile Asn Ser Val Leu Gln Leu Val Gly Val Gln His Val Asn Phe
                 165                 170                 175

 aca aac aga cct tca gtt atc cat gtg tga                              558
 Thr Asn Arg Pro Ser Val Ile His Val 
             180                 185





      <210> 193
      <211> 1320
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(426)

      <400> 193
  atg gcc gcg ccg gcc ccg gtc acg cgg cag gtt agc ggc gcc gcc gcc      48
  Met Ala Ala Pro Ala Pro Val Thr Arg Gln Val Ser Gly Ala Ala Ala
    1               5                  10                  15

 ctg gtc ccg gcc ccg agc ggc ccc gac agc ggg cag ccc ctg gcg gcc       96
 Leu Val Pro Ala Pro Ser Gly Pro Asp Ser Gly Gln Pro Leu Ala Ala
              20                  25                  30

 gcc gtg gcc gag ctg ccg gtg ctg gac gcc cgc ggg cag cgg gta ccg      144
 Ala Val Ala Glu Leu Pro Val Leu Asp Ala Arg Gly Gln Arg Val Pro
          35                  40                  45

 ttc ggc gcg ctg ttc cgg gag cgc cgc gcc gtg gtg gtg ttc gtg cgg      192
 Phe Gly Ala Leu Phe Arg Glu Arg Arg Ala Val Val Val Phe Val Arg
      50                  55                  60

 cct ttt tgc aag ctg act gga tat tct cat gaa atc tat gtc gat cct      240
 Pro Phe Cys Lys Leu Thr Gly Tyr Ser His Glu Ile Tyr Val Asp Pro
  65                  70                  75                  80

 gag aga gaa att tat aaa aga ttg gga atg aaa aga ggt gaa gaa att      288
 Glu Arg Glu Ile Tyr Lys Arg Leu Gly Met Lys Arg Gly Glu Glu Ile
                  85                  90                  95

 gct tcc tca ggt aac aac atc cat ttt ata cac cgc gat agg aat agg      336
 Ala Ser Ser Gly Asn Asn Ile His Phe Ile His Arg Asp Arg Asn Arg
             100                 105                 110

 ttg gat cac aaa cct atc aac tct gtt tta cag ctt gta gga gtt cag      384
 Leu Asp His Lys Pro Ile Asn Ser Val Leu Gln Leu Val Gly Val Gln
         115                 120                 125

 cat gtg aac ttt aca aac aga cct tca gtt atc cat gtg tga cttaaaa      433
 His Val Asn Phe Thr Asn Arg Pro Ser Val Ile His Val 
     130                 135                 140

 tgcactcagt cactttcaac tggaccttct ggaatgtgac cttcaatgcc tgggtgtaat    493

 atcctcgtgc agtgtctaac ctgctgtccc ttcccagcct ttgaggagtt agggaagcat    553

 aaagggggct tgaacctgtt gaattgcatg ctgggaagca tcagttgtca aaatatgtta    613

 tatacttcca ttttataact tttaacattt tatacaaaaa aaatgaatat acaaaatata    673

 actttaaaag ctataaaatc ataaatactc taaattattt tacattatgg tatattcagt    733

 caatgaaaga gttttttggc aatataaatt ctgacagtat ataaggggac aggagaacaa    793

 cacaagacca ttatattcag tgaagaaggc aaaatatcaa atctgtcaac aatgtaactg    853

 catttttata tgtatatatt tgtatttttg tatgctttgg aaaaagacag gaaataaaca    913

 ccaaaatgtt gccagtaggt atctctgtgt taagattagt gttattattt tcttttctgt    973

 acttttctgt atttcccaac tgttatataa tgagcatgat taatattgta gggccaggaa   1033

 aaggtcttta aacattatag gacaatttta tgccacataa caaccttcac aaaagagcaa   1093

 aattatataa gctgtagtcc acttttccat cgtaattgct ttactcagag gaagtgtggc   1153

 aatccgaaca tttcacatat agccagtgtc cacagcacct tctcaaacta catacttgct   1213

 atccgtttca ctaggatttt ggggggttgg gggagctatg gagtatcaaa ttgttttaga   1273

 tatataagat atgtatttaa aaatcggacg cgtgggtcga ccgagaa                 1320




      <210> 194
      <211> 1467
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1467)

      <400> 194
  atg aag tgt gag cac tgc acg cgc aag gaa tgt agt aag aaa aca aaa      48
  Met Lys Cys Glu His Cys Thr Arg Lys Glu Cys Ser Lys Lys Thr Lys
    1               5                  10                  15

 act gat gac caa gag aat gtg tca gcc gat gca ccg agt cca gcc cag       96
 Thr Asp Asp Gln Glu Asn Val Ser Ala Asp Ala Pro Ser Pro Ala Gln
              20                  25                  30

 gaa aat gga gag aag gga gaa ttc cac aag ttg gct gat gcc aag ata      144
 Glu Asn Gly Glu Lys Gly Glu Phe His Lys Leu Ala Asp Ala Lys Ile
          35                  40                  45

 ttt ttg agc gac tgc ctg gca tgt gac agc tgt atg act gca gag gaa      192
 Phe Leu Ser Asp Cys Leu Ala Cys Asp Ser Cys Met Thr Ala Glu Glu
      50                  55                  60

 gga gtc caa ctt tcc cag caa aat gcc aag gac ttc ttc cgc gtt ctg      240
 Gly Val Gln Leu Ser Gln Gln Asn Ala Lys Asp Phe Phe Arg Val Leu
  65                  70                  75                  80

 aac ctt aac aag aaa tgt gat acc tca aag cac aaa gtg ctg gta gtg      288
 Asn Leu Asn Lys Lys Cys Asp Thr Ser Lys His Lys Val Leu Val Val
                  85                  90                  95

 tct gtg tgt cct caa tct ttg cct tat ttt gct gct aaa ttc aac ctc      336
 Ser Val Cys Pro Gln Ser Leu Pro Tyr Phe Ala Ala Lys Phe Asn Leu
             100                 105                 110

 agt gta act gat gca tcc aga aga ctc tgt ggt ttc ctc aaa agt ctt      384
 Ser Val Thr Asp Ala Ser Arg Arg Leu Cys Gly Phe Leu Lys Ser Leu
         115                 120                 125

 ggg gtg cac tat gta ttt gat acg acg ata gct gcg gat ttt agt atc      432
 Gly Val His Tyr Val Phe Asp Thr Thr Ile Ala Ala Asp Phe Ser Ile
     130                 135                 140

 ctg gag agt caa aaa gaa ttc gtg cgt cgc tat cgc cag cac agt gag      480
 Leu Glu Ser Gln Lys Glu Phe Val Arg Arg Tyr Arg Gln His Ser Glu
 145                 150                 155                 160

 gag gaa cgc acc ctg ccc atg ctg acc tct gcc tgt cct ggc tgg gtc      528
 Glu Glu Arg Thr Leu Pro Met Leu Thr Ser Ala Cys Pro Gly Trp Val
                 165                 170                 175

 cga tac gcc gag cgg gtg ctg ggt cgc ccc atc act gcc cac ctc tgc      576
 Arg Tyr Ala Glu Arg Val Leu Gly Arg Pro Ile Thr Ala His Leu Cys
             180                 185                 190

 acc gcc aag tcc ccc cag cag gtc atg ggc tct ttg gtg aag gat tat      624
 Thr Ala Lys Ser Pro Gln Gln Val Met Gly Ser Leu Val Lys Asp Tyr
         195                 200                 205

 ttc gcc aga cag cag aac ctg tct cca gag aag att ttc cac gtc att      672
 Phe Ala Arg Gln Gln Asn Leu Ser Pro Glu Lys Ile Phe His Val Ile
     210                 215                 220

 gtg gcc cct tgt tat gac aag aag ctg gag gct ctt cag gaa agc ctt      720
 Val Ala Pro Cys Tyr Asp Lys Lys Leu Glu Ala Leu Gln Glu Ser Leu
 225                 230                 235                 240

 ccc cct gct ttg cat ggc tcc cgg ggc gct gac tgc gtg tta aca tca      768
 Pro Pro Ala Leu His Gly Ser Arg Gly Ala Asp Cys Val Leu Thr Ser
                 245                 250                 255

 ggt gaa att gct caa ata atg gag caa ggt gac ctc tca gtg aga gat      816
 Gly Glu Ile Ala Gln Ile Met Glu Gln Gly Asp Leu Ser Val Arg Asp
             260                 265                 270

 gct gcc gtc gac act ctg ttt gga gac ttg aag gag gac aaa gtg acg      864
 Ala Ala Val Asp Thr Leu Phe Gly Asp Leu Lys Glu Asp Lys Val Thr
         275                 280                 285

 cgt cat gat gga gcc agc tca gac ggg cac ctg gca cac atc ttc aga      912
 Arg His Asp Gly Ala Ser Ser Asp Gly His Leu Ala His Ile Phe Arg
     290                 295                 300

 cat gcg gcc aag gag ctg ttc aac gag gat gtg gag gag gtc act tac      960
 His Ala Ala Lys Glu Leu Phe Asn Glu Asp Val Glu Glu Val Thr Tyr
 305                 310                 315                 320

 cga gcc ctg aga aac aaa gac ttc caa gag gtc acc ctt gag aag aac     1008
 Arg Ala Leu Arg Asn Lys Asp Phe Gln Glu Val Thr Leu Glu Lys Asn
                 325                 330                 335

 gga gag gtg gtg tta cgc ttt gct gca gcc tat ggc ttt cga aac atc     1056
 Gly Glu Val Val Leu Arg Phe Ala Ala Ala Tyr Gly Phe Arg Asn Ile
             340                 345                 350

 cag aac atg atc ctg aag ctt aag aag ggc aag ttc cca ttc cac ttt     1104
 Gln Asn Met Ile Leu Lys Leu Lys Lys Gly Lys Phe Pro Phe His Phe
         355                 360                 365

 gtg gag gtc ctc gcc tgt gct gga gga tgc tta aat ggc aga ggc caa     1152
 Val Glu Val Leu Ala Cys Ala Gly Gly Cys Leu Asn Gly Arg Gly Gln
     370                 375                 380

 gcc cag act cca gac gga cat gcg gat aag gcc tgc tgc ggc aga tgg     1200
 Ala Gln Thr Pro Asp Gly His Ala Asp Lys Ala Cys Cys Gly Arg Trp
 385                 390                 395                 400

 aag gca ttt acg ctg aca tcc ctg tgc ggc gtc cgg agt cca gtg cac     1248
 Lys Ala Phe Thr Leu Thr Ser Leu Cys Gly Val Arg Ser Pro Val His
                 405                 410                 415

 acg tgc agg agc tgt acc agg agt ggc tgg agg gga tca act ccc cca     1296
 Thr Cys Arg Ser Cys Thr Arg Ser Gly Trp Arg Gly Ser Thr Pro Pro
             420                 425                 430

 agg ccc gag agg tgc tgc ata cca cgt acc aga gcc agg agc gtg gca     1344
 Arg Pro Glu Arg Cys Cys Ile Pro Arg Thr Arg Ala Arg Ser Val Ala
         435                 440                 445

 cac aca gcc tgg aca tca agt ggt gaa gtc agg cca ggg cct tcc agc     1392
 His Thr Ala Trp Thr Ser Ser Gly Glu Val Arg Pro Gly Pro Ser Ser
     450                 455                 460

 tgc tct tgg ggc cag agc caa gag cct ctc agt aga ggg agg ggc tgc     1440
 Cys Ser Trp Gly Gln Ser Gln Glu Pro Leu Ser Arg Gly Arg Gly Cys
 465                 470                 475                 480

 cct gag tgg agt att aaa gac act taa                                 1467
 Pro Glu Trp Ser Ile Lys Asp Thr 
                 485





      <210> 195
      <211> 2808
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (929)..(1246)

      <220>
      <221> misc_feature
      <222> (1)...(2808)
      <223> n = a,t,c or g

      <400> 195
 atggacagag ctgaagagcc aacttgtgaa ttggaggact cagctaagga gttctctgaa     60

 agtgcaccac atagaataag gctttgtaat cagaagacta gaagtttatc gtctgctaga    120

 gcagaggggg acgctggact tcggacatca gtgcgacccc tgtggcctgc atttccggca    180

 caagagtcaa ctgcggctgc atctgcgcca gaaacacgga gctgctacca acaccaaagt    240

 gcgctaccac attctcgggg ggccctatct gagcgcaggc ccaggcccca cttgcttcct    300

 gcgggtggga aagctgcagg cccaggcctt gcttccctat caggcttggg cataggggtg    360

 tgccaggcca ctttggtatc agaaattgcc accctcttaa tttctcactg gggagagcag    420

 gggtggcaga tcctggctag atctgcctct gttttgctgg tcaaaacctc ttccccacaa    480

 gccagattgt ttctgaggag agagctagct aggggctggg aaaggggaga gattggagtc    540

 ctggtctccc taagggaata gccctccacc tgtggccccc attgcattca gtttatctgt    600

 aaatataatt tattgaggcc tttgggtggc accggggcct tcattcgatt gcatttccca    660

 ctcccctctt ccacaagtgt gattaaaagt gaccagaaac acagaaggtg agatcacagc    720

 tctgctggca gagattacta gcccttggct ctctcgtttg gcttgggtat tttatattat    780

 ttctgtcata acttttatct ttagaattgt tctttctcct gtttgtttgc ttgttagttt    840

 gtttaaaatg gaaaaagggg ttctctgtgt tctgcccctg taattctagg tctggaacct    900

 ttatttgttc tagggcagct ctgggaac   atg cgg gat ttg tgg aat tgg gtc     952
                                  Met Arg Asp Leu Trp Asn Trp Val
                                    1               5

 agg aac cct ctc tgg tat tct gga tgt tgt agg ttc tct agc agt cta     1000
 Arg Asn Pro Leu Trp Tyr Ser Gly Cys Cys Arg Phe Ser Ser Ser Leu
      10                  15                  20

 gaa atg gat aca gac att tct ctg ttc ttc aag ggt gat agg aac cat     1048
 Glu Met Asp Thr Asp Ile Ser Leu Phe Phe Lys Gly Asp Arg Asn His
  25                  30                  35                  40

 tat gtt gag ccc aaa atg gaa gta ata ata aat gcc tcc tgg agg ctg     1096
 Tyr Val Glu Pro Lys Met Glu Val Ile Ile Asn Ala Ser Trp Arg Leu
                  45                  50                  55

 tgg gtg tgg ggg att ctg tat ctg gat tcc gta tca ctc caa ctg gag     1144
 Trp Val Trp Gly Ile Leu Tyr Leu Asp Ser Val Ser Leu Gln Leu Glu
              60                  65                  70

 gct gtg ggt gtg ggg gat tct gta tct gga ttc cgt atc act cca agt     1192
 Ala Val Gly Val Gly Asp Ser Val Ser Gly Phe Arg Ile Thr Pro Ser
          75                  80                  85

 gga ggc tgg cag gtt ttt ctg caa gat ggt cca gaa tct aaa atg tcc     1240
 Gly Gly Trp Gln Val Phe Leu Gln Asp Gly Pro Glu Ser Lys Met Ser
      90                  95                 100

 cat taa tctggtcact tgggtttggc tctgctgtat ccatctatag tggtagagac      1296
 His 
 105

 ccaccagggc tcaagtggag tccatcatcc tcccacgggg gcctgttctt agcactgagt   1356

 tgatcgctcc atgggggaga gatcagacat tccttatcag agatgatgtg accttttctg   1416

 actctgccca gtctctatga atgttatggc ctagggaaga atcatgaaac tctttagctt   1476

 gattagatgg taaacagtgt taacccatcc tttactacag aggcatatgg gtttgaatgt   1536

 tacctggggt tctctctatt gagttgagcc ccttcttcct ttagtgggtt ttggacatct   1596

 tctggcaagt gtccagatgc cagaaccttc ttttcctcta gaagggatgg tgcttggtaa   1656

 ccttaccttt taaaagctgg gtctgtgacc tggtcttccc atccctgcat tcctgtctgg   1716

 aaccagtgaa tgcattagaa ccttccatag gaaaagaaaa ggggctgagt tccattctgg   1776

 gtttgctgta gtttggttgg gattattgtt ggcattacag atgtaaaaga ttgactagcc   1836

 cataggccaa aggcctgttc tagttgacca agtttcaagt aggattaaga ggttggttga   1896

 ggggtgcagt ttctggtgta ggccaggtag gtagaaagtg aggaacaggg ttgcctcttg   1956

 gctgggtgga gtctctgaaa tgttagaaga agcgctgaag ccttgattga tagttctgcc   2016

 ccttgttgcc ctggggctta tctgattatg ggacgagggt agaaagtaag aagcactttt   2076

 gaatttgtgg ggtagaactt caacaataag tcagttctag tggctgtcgc ctggggacta   2136

 gtgagaaagc tactcttctc cctcttccct ctttctcccc atggccccac tgcagaatta   2196

 aagaaggaag aagggaaggc ggaggagtct ataagaagga atcatgattt ctatttagca   2256

 gattggatgg gcaggtggag aatgcctggg ggtagaaatg ttagatcttg caacatcaga   2316

 tccttggaat aaagaagcct ctctgtgctg cctgctgtgt cctgggttct tgccttgggg   2376

 gactcgggga gcgaggaaga gagctcttcc tcctggataa catcttggat tctgtaccat   2436

 tccactgtcc cttcccacca gacattttaa atggtcctcg ttgtcccctt ccctgccctt   2496

 gccttcctgc tcattgtgta gggaaccagt gacttcaatg aagtttctcc ggagccacct   2556

 gcatcctgct gctctggaag tcactttcct gccgaaggtg ttggaaggcg gcaagggaga   2616

 aacagggnga gccatgaata atattccaag agggcccggg cgtgaatctc gtgcgggaaa   2676

 tctttaaatg cggggcgaca ggcttccaag aaccagggag tagggataag aattgggttc   2736

 ccaataagcc caagggctcg gaagttgggc cttggagaac ttagtttagg atttaacggg   2796

 gcccaccaac tg                                                       2808




      <210> 196
      <211> 456
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (76)..(402)

      <400> 196
 ttccgggtcg acccacgcgt ccgcgcgggc ctcggccagg cctgagatgc cgggagggtt     60

 tgaccctggg gctgc atg gac agc tta gcg ctc ggc cgc tgg cga cag cgg     111
                  Met Asp Ser Leu Ala Leu Gly Arg Trp Arg Gln Arg
                    1               5                  10

 agg gcg gag gat ctg cag gtt ccg ggg gac gtg aaa cgg gta tgc agg      159
 Arg Ala Glu Asp Leu Gln Val Pro Gly Asp Val Lys Arg Val Cys Arg
          15                  20                  25

 aga tta gaa gcc agt ggg cat gag cgt ggc tgc cac cag gtg aat gcc      207
 Arg Leu Glu Ala Ser Gly His Glu Arg Gly Cys His Gln Val Asn Ala
      30                  35                  40

 tgt gcc ctg gca tcc tgg ggc cca gag gac cgg gag ctt cca tca aga      255
 Cys Ala Leu Ala Ser Trp Gly Pro Glu Asp Arg Glu Leu Pro Ser Arg
  45                  50                  55                  60

 ggc tgc ctc cca gca cca agg cca gag agt ggc cag ggg agg cta agt      303
 Gly Cys Leu Pro Ala Pro Arg Pro Glu Ser Gly Gln Gly Arg Leu Ser
                  65                  70                  75

 aca ggg att tct cag aat ggt gga agg agc tca gcc cag cct tgc cca      351
 Thr Gly Ile Ser Gln Asn Gly Gly Arg Ser Ser Ala Gln Pro Cys Pro
              80                  85                  90

 aga tgt att gca ggg gaa tct gga cat ttt agc cat acc aag aat cat      399
 Arg Cys Ile Ala Gly Glu Ser Gly His Phe Ser His Thr Lys Asn His
          95                 100                 105

 tag aaga tgcaagctgg aaaaaagaag gtcccagttt tggttttgaa cccttcatgt      456
 






      <210> 197
      <211> 590
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (33)..(536)

      <400> 197
 cccggcccct ggcccgctcg cccgccggca cc  atg atg gag gag atc gac cgg      53
                                      Met Met Glu Glu Ile Asp Arg
                                        1               5

 ttc cag gtg ccc acc gcg cac tcg gag atg cag ccg ctg gac cca gcc      101
 Phe Gln Val Pro Thr Ala His Ser Glu Met Gln Pro Leu Asp Pro Ala
          10                  15                  20

 gcc gcc tcc atc tct gac gga gac tgt gac gcc cgg gag gag aag cag      149
 Ala Ala Ser Ile Ser Asp Gly Asp Cys Asp Ala Arg Glu Glu Lys Gln
      25                  30                  35

 cgg gag ctg gcc cgg aag ggc tcc ctg aag aat ggc agc atg ggt agc      197
 Arg Glu Leu Ala Arg Lys Gly Ser Leu Lys Asn Gly Ser Met Gly Ser
  40                  45                  50                  55

 cct gtc aac cag caa ccc aag aag aac aat gtc atg gcc cga aca agg      245
 Pro Val Asn Gln Gln Pro Lys Lys Asn Asn Val Met Ala Arg Thr Arg
                  60                  65                  70

 ctg gtc gtc ccc aat aaa ggc tac tcc tca ctt gac cag agc cct gat      293
 Leu Val Val Pro Asn Lys Gly Tyr Ser Ser Leu Asp Gln Ser Pro Asp
              75                  80                  85

 gag aag cca ctg gta gcc ctt gac acg gac agc gat gat gac ttt gac      341
 Glu Lys Pro Leu Val Ala Leu Asp Thr Asp Ser Asp Asp Asp Phe Asp
          90                  95                 100

 atg tct aga tac tcc tcc tcc ggc tac tcc tct gct gag atc aac caa      389
 Met Ser Arg Tyr Ser Ser Ser Gly Tyr Ser Ser Ala Glu Ile Asn Gln
     105                 110                 115

 gat ttg aac atc cag ctg ctg aag gac ggc tac cgg tta gat gag atc      437
 Asp Leu Asn Ile Gln Leu Leu Lys Asp Gly Tyr Arg Leu Asp Glu Ile
 120                 125                 130                 135

 ccc gac gac gag gac cta gac ctc atc ccc ccc aag tcc gtg aac ccc      485
 Pro Asp Asp Glu Asp Leu Asp Leu Ile Pro Pro Lys Ser Val Asn Pro
                 140                 145                 150

 acg tgc atg tgc tgc cag gcc acg tcc tcc acc gcc tgc cac att cag      533
 Thr Cys Met Cys Cys Gln Ala Thr Ser Ser Thr Ala Cys His Ile Gln
             155                 160                 165

 tag cggg cggggccact gcggtcgccg gggcggggcc gccaagggcc gggtaggacg      590
 






      <210> 198
      <211> 638
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (34)..(588)

      <400> 198
 gcccggcccc tggcccgctc gcccgccggc acc atg atg gag gag atc gac cgg      54
                                      Met Met Glu Glu Ile Asp Arg
                                        1               5

 ttc cag gtg ccc acc gcg cac tcg gag atg cag ccg ctg gac cca gcc      102
 Phe Gln Val Pro Thr Ala His Ser Glu Met Gln Pro Leu Asp Pro Ala
          10                  15                  20

 gcc gcc tcc atc tct gac gga gac tgt gac gcc cgg gag ggt gag tca      150
 Ala Ala Ser Ile Ser Asp Gly Asp Cys Asp Ala Arg Glu Gly Glu Ser
      25                  30                  35

 gta gcc atg aat tac aaa cca tcc ccg ctc caa gtg aag ctg gag aag      198
 Val Ala Met Asn Tyr Lys Pro Ser Pro Leu Gln Val Lys Leu Glu Lys
  40                  45                  50                  55

 cag cgg gag ctg gcc cgg aag ggc tcc ctg aag aat ggc agc atg ggt      246
 Gln Arg Glu Leu Ala Arg Lys Gly Ser Leu Lys Asn Gly Ser Met Gly
                  60                  65                  70

 agc cct gtc aac cag caa ccc aag aag aac aat gtc atg gcc cga aca      294
 Ser Pro Val Asn Gln Gln Pro Lys Lys Asn Asn Val Met Ala Arg Thr
              75                  80                  85

 agg ctg gtc gtc ccc aat aaa ggc tac tcc tca ctt gac cag agc cct      342
 Arg Leu Val Val Pro Asn Lys Gly Tyr Ser Ser Leu Asp Gln Ser Pro
          90                  95                 100

 gat gag aag cca ctg gta gcc ctt gac acg gac agc gat gat gac ttt      390
 Asp Glu Lys Pro Leu Val Ala Leu Asp Thr Asp Ser Asp Asp Asp Phe
     105                 110                 115

 gac atg tct aga tac tcc tcc tcc ggc tac tcc tct gct gag atc aac      438
 Asp Met Ser Arg Tyr Ser Ser Ser Gly Tyr Ser Ser Ala Glu Ile Asn
 120                 125                 130                 135

 caa gat ttg aac atc cag ctg ctg aag gac ggc tac cgg tta gat gag      486
 Gln Asp Leu Asn Ile Gln Leu Leu Lys Asp Gly Tyr Arg Leu Asp Glu
                 140                 145                 150

 atc ccc gac gac gag gac cta gac ctc atc ccc ccc aag tcc gtg aac      534
 Ile Pro Asp Asp Glu Asp Leu Asp Leu Ile Pro Pro Lys Ser Val Asn
             155                 160                 165

 ccc acg tgc atg tgc tgc cag gcc acg tcc tcc acc gcc tgc cac att      582
 Pro Thr Cys Met Cys Cys Gln Ala Thr Ser Ser Thr Ala Cys His Ile
         170                 175                 180

 cag tag cgggcggggc cactgcggtc gccggggcgg ggccgccaag ggccgggtag       638
 Gln 






      <210> 199
      <211> 1238
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (34)..(555)

      <400> 199
 gcccggcccc tggcccgctc gcccgccggc acc atg atg gag gag atc gac cgg      54
                                      Met Met Glu Glu Ile Asp Arg
                                        1               5

 ttc cag gac cca gcc gcc gcc tcc atc tct gac gga gac tgt gac gcc      102
 Phe Gln Asp Pro Ala Ala Ala Ser Ile Ser Asp Gly Asp Cys Asp Ala
          10                  15                  20

 cgg gag ggt gag tca gta gcc atg aat tac aaa cca tcc ccg ctc caa      150
 Arg Glu Gly Glu Ser Val Ala Met Asn Tyr Lys Pro Ser Pro Leu Gln
      25                  30                  35

 gtg aag ctg gag aag cag cgg gag ctg gcc cgg aag ggc tcc ctg aag      198
 Val Lys Leu Glu Lys Gln Arg Glu Leu Ala Arg Lys Gly Ser Leu Lys
  40                  45                  50                  55

 aat ggc agc atg ggt agc cct gtc aac cag caa ccc aag aag aac aat      246
 Asn Gly Ser Met Gly Ser Pro Val Asn Gln Gln Pro Lys Lys Asn Asn
                  60                  65                  70

 gtc atg gcc cga aca agg ctg gtc gtc ccc aat aaa ggc tac tcc tca      294
 Val Met Ala Arg Thr Arg Leu Val Val Pro Asn Lys Gly Tyr Ser Ser
              75                  80                  85

 ctt gac cag agc cct gat gag aag cca ctg gta gcc ctt gac acg gac      342
 Leu Asp Gln Ser Pro Asp Glu Lys Pro Leu Val Ala Leu Asp Thr Asp
          90                  95                 100

 agc gat gat gac ttt gac atg tct aga tac tcc tcc tcc ggc tac tcc      390
 Ser Asp Asp Asp Phe Asp Met Ser Arg Tyr Ser Ser Ser Gly Tyr Ser
     105                 110                 115

 tct gct gag atc aac caa gat ttg aac atc cag ctg ctg aag gac ggc      438
 Ser Ala Glu Ile Asn Gln Asp Leu Asn Ile Gln Leu Leu Lys Asp Gly
 120                 125                 130                 135

 tac cgg tta gat gag atc ccc gac gac gag gac cta gac ctc atc ccc      486
 Tyr Arg Leu Asp Glu Ile Pro Asp Asp Glu Asp Leu Asp Leu Ile Pro
                 140                 145                 150

 ccc aag tcc gtg aac ccc acg tgc atg tgc tgc cag gcc acg tcc tcc      534
 Pro Lys Ser Val Asn Pro Thr Cys Met Cys Cys Gln Ala Thr Ser Ser
             155                 160                 165

 acc gcc tgc cac att cag tag cg ggcggggcca ctgcggtcgc cggggcgggg      587
 Thr Ala Cys His Ile Gln 
         170

 ccgccaaggg ccgggtagga cgggcagagg ccgacccctt cccagctcgt ctgcctgccc    647

 ccggccccgc gcccctacag ccgccaacct cgtataacag tcattgcttc ctcctatggt    707

 aggacgtgta cctctgtgtg ttcatggagc tggagaaacc aaaactgggt ctctctccac    767

 ccgggagctg aggaggggtg ggggccgttt gttcagttac ctgggggaac ctcacccagc    827

 accctgcccc gcttcccagg gctggccaag agagaagact ggacggcagg gaggtcaaca    887

 ttaacgagtg gggggatcac aaagccaggg gcttggcccc accccagcga agccatgaac    947

 tcccaagccc cggcctcagc ctaaccagga aaggggctcg gagggagaaa ggcccagggc   1007

 agtggggacg ggtcccagca cctcggagcc cccttcacac gccccctacc ggcccatgtt   1067

 tctatttgca tttccccctc ctcagatggg aagcctggca aagctgccca accgggtagt   1127

 gcccctcacc catcggatca ctgccttctt cctcctcttg ccccattcac ccgcttcctt   1187

 gcactctggg agtggggcag ggtaaggtgg gccttacaga caggctgagg t            1238




      <210> 200
      <211> 2323
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (697)..(2088)

      <220>
      <221> misc_feature
      <222> (1)...(2323)
      <223> n = a,t,c or g

      <400> 200
 cgcgcttcct ctcgccaggc ctgcgagctt cctcccagcg gagccctggg cgagccgagg     60

 ttggccgccg ccgccgccga gcccgctgcc gccctcccgc tcctgcccca cccgcgcctt    120

 ggccgggggc ttctgccggg gtggggtccg agccgggcga ccgcccggct gcgccgccgt    180

 cggggccgta acccggcccg ccgtccctcc cgccccagcc agcctctggc cgccggagcc    240

 cgcggggcgt ggagcgcgag gagccccgcg gccccgatcg agcgtccggg gcggcccccg    300

 gcagccagcg cgacgttcca aaatcgaacc tcagtggcgg cgctcggaag cggaactctg    360

 ccggggccgc gccggctaca ttgtttcctg cgtgcgactg cctcccgccc ccttcccccg    420

 cctttcttcc ctccgcgacc cgggccgtgc gtccgtcccc ctgcctctgc ctggcggtcc    480

 ctcctcccct ctccttgcac ccatacctct ttgtaccgca ccccctgggg acccctgcgc    540

 ccctcccctc ccccctgacc gcatggaccg tcccgcaggc cgctgatgcc gcccgcggcg    600

 aggtggcccg gaccgcagtg ccccaagaga gctctaatgg taccaagtga caggttggct    660

 ttactgtgac tcggggacgc cagagctcct gagaag  atg tca gca ata cag gcc     714
                                          Met Ser Ala Ile Gln Ala
                                            1               5

 gcc tgg cca tcc ggt aca gaa tgt att gcc aag tac aac ttc cac ggc      762
 Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala Lys Tyr Asn Phe His Gly
              10                  15                  20

 act gcc gag cag gac ctg ccc ttc tgc aaa gga gac gtg ctc acc att      810
 Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys Gly Asp Val Leu Thr Ile
          25                  30                  35

 gtg gcc gtc acc aag gac ccc aac tgg tac aaa gcc aaa aac aag gtg      858
 Val Ala Val Thr Lys Asp Pro Asn Trp Tyr Lys Ala Lys Asn Lys Val
      40                  45                  50

 ggc cgt gag ggc atc atc cca gcc aac tac gtc cag aag cgg gag ggc      906
 Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr Val Gln Lys Arg Glu Gly
  55                  60                  65                  70

 gtg aag gcg ggt acc aaa ctc agc ctc atg cct tgg ttc cac ggc aag      954
 Val Lys Ala Gly Thr Lys Leu Ser Leu Met Pro Trp Phe His Gly Lys
                  75                  80                  85

 atc aca cgg gag cag gct gag cgg ctt ctg tac ccg ccg gag aca ggc     1002
 Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu Tyr Pro Pro Glu Thr Gly
              90                  95                 100

 ctg ttc ctg gtg cgg gag agc acc aac tac ccc gga gac tac acg ctg     1050
 Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr Pro Gly Asp Tyr Thr Leu
         105                 110                 115

 tgc gtg agc tgc gac ggc aag gtg gag cac tac cgc atc atg tac cat     1098
 Cys Val Ser Cys Asp Gly Lys Val Glu His Tyr Arg Ile Met Tyr His
     120                 125                 130

 gcc agc aag ctc agc atc gac gag gag gtg tac ttt gag aac ctc atg     1146
 Ala Ser Lys Leu Ser Ile Asp Glu Glu Val Tyr Phe Glu Asn Leu Met
 135                 140                 145                 150

 cag ctg gtg gag cac tac acc tca gac gca gat gga ctc tgt acg cgc     1194
 Gln Leu Val Glu His Tyr Thr Ser Asp Ala Asp Gly Leu Cys Thr Arg
                 155                 160                 165

 ctc att aaa cca aag gtc atg gag ggc aca gtg gcg gcc cag gat gag     1242
 Leu Ile Lys Pro Lys Val Met Glu Gly Thr Val Ala Ala Gln Asp Glu
             170                 175                 180

 ttc tac cgc agc ggc tgg gcc ctg aac atg aag gag ctg aag ctg ctg     1290
 Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met Lys Glu Leu Lys Leu Leu
         185                 190                 195

 cag acc atc ggg aag ggg gag ttc gga gac gtg atg ctg ggc gat tac     1338
 Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp Val Met Leu Gly Asp Tyr
     200                 205                 210

 cga ggg aac aaa gtc gcc gtc aag tgc att aag aac gac gcc act gcc     1386
 Arg Gly Asn Lys Val Ala Val Lys Cys Ile Lys Asn Asp Ala Thr Ala
 215                 220                 225                 230

 cag gcc ttc ctg gct gaa gcc tca gtc atg acg caa ctg cgg cat agc     1434
 Gln Ala Phe Leu Ala Glu Ala Ser Val Met Thr Gln Leu Arg His Ser
                 235                 240                 245

 aac ctg gtg cag ctc ctg ggc gtg atc gtg gag gag aag ggc ggg ctc     1482
 Asn Leu Val Gln Leu Leu Gly Val Ile Val Glu Glu Lys Gly Gly Leu
             250                 255                 260

 tac atc gtc act gag tac atg gcc aag ggg agc ctt gtg gac tac ctg     1530
 Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly Ser Leu Val Asp Tyr Leu
         265                 270                 275

 cgg tct agg ggt cgg tca gtg ctg ggc gga gac tgt ctc ctc aag ttc     1578
 Arg Ser Arg Gly Arg Ser Val Leu Gly Gly Asp Cys Leu Leu Lys Phe
     280                 285                 290

 tcg cta gat gtc tgc gag gcc atg gaa tac ctg gag ggc aac aat ttc     1626
 Ser Leu Asp Val Cys Glu Ala Met Glu Tyr Leu Glu Gly Asn Asn Phe
 295                 300                 305                 310

 gtg cat cga gac ctg gct gcc cgc aat gtg ctg gtg tct gag gac aac     1674
 Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Ser Glu Asp Asn
                 315                 320                 325

 gtg gcc aag gtc agc gac ttt ggt ctc acc aag gag gcg tcc agc acc     1722
 Val Ala Lys Val Ser Asp Phe Gly Leu Thr Lys Glu Ala Ser Ser Thr
             330                 335                 340

 cag gac acg ggc aag ctg cca gtc aag tgg aca gcc cct gag gcc ctg     1770
 Gln Asp Thr Gly Lys Leu Pro Val Lys Trp Thr Ala Pro Glu Ala Leu
         345                 350                 355

 aga gag aag aaa ttc tcc act aag tct gac gtg tgg agt ttc gga atc     1818
 Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp Val Trp Ser Phe Gly Ile
     360                 365                 370

 ctt ctc tgg gaa atc tac tcc ttt ggg cga gtg cct tat cca aga att     1866
 Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg Val Pro Tyr Pro Arg Ile
 375                 380                 385                 390

 ccc ctg aag gac gtc gtc cct cgg gtg gag aag ggc tac aag atg gat     1914
 Pro Leu Lys Asp Val Val Pro Arg Val Glu Lys Gly Tyr Lys Met Asp
                 395                 400                 405

 gcc ccc gac ggc tgc ccg ccc gca gtc tat gaa gtc atg aag aac tgc     1962
 Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr Glu Val Met Lys Asn Cys
             410                 415                 420

 tgg cac ctg gac gcc gcc atg cgg ccc tcc tcc tac agc tcc gag agc     2010
 Trp His Leu Asp Ala Ala Met Arg Pro Ser Ser Tyr Ser Ser Glu Ser
         425                 430                 435

 agc ttg agc aca tca aaa ccc acg agc tgc acc tgt gac ggc tgg cct     2058
 Ser Leu Ser Thr Ser Lys Pro Thr Ser Cys Thr Cys Asp Gly Trp Pro
     440                 445                 450

 ccg cct ggg tca tgg gcc tgt ggg gac tga a cctggaagat catggacctg     2109
 Pro Pro Gly Ser Trp Ala Cys Gly Asp 
 455                 460

 gtgcccctgc ttcactgggc ccgagcctgn aactgagccc cagcggctgg gcggngcctt   2169

 tttcctgcgt cccagcctgc acccctccgg ccccgtcttt tttgggaccc acctgtgggg   2229

 cttgggggga gcccacttga ggggccaggg gaggaaggag ggccaaggaa gcggggaggc   2289

 agcgcccaac caagttnggg ttttccttgg gctt                               2323




      <210> 201
      <211> 1088
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (447)..(1031)

      <220>
      <221> misc_feature
      <222> (1)...(1088)
      <223> n = a,t,c or g

      <400> 201
 cagacaggtg atctctacca gaatatcatt ggctccacac ctgatctgga cccagagaca     60

 gtggatgatg cctttgctcg tgccttccaa gtctggagcg atgtgacccc actgcggttt    120

 tctcgaatcc atgatggaga ggcagacatc atgatcaact ttggccgctg ggagcatggc    180

 gatggatacc cctttgacgg taaggacgga ctcctggctc atgccttcgc cccaggcact    240

 ggtgttgggg gagactccca ttttgatgac gatgagctat ggaccttggg aaaaagccaa    300

 gtggtccgtg tgaagtatgg gatcgacgat ggggagtact gcaagctccc cttcttgttc    360

 aatggcaagg agtacaacag ctgcnttgat accggccgca agcgatggct tcctctggtg    420

 ctccaccacn tacaactttg agaagg atg gca agt acg gct tct gtc ccc aaa     473
                              Met Ala Ser Thr Ala Ser Val Pro Lys
                                1               5

 acg gac aaa gag ttg gca gtg caa tac ctg aac acc ttc tat ggc tgc      521
 Thr Asp Lys Glu Leu Ala Val Gln Tyr Leu Asn Thr Phe Tyr Gly Cys
  10                  15                  20                  25

 ccc aag gag agc tgc aac ctg ttt gtg ctg aag gac aca cta aag aag      569
 Pro Lys Glu Ser Cys Asn Leu Phe Val Leu Lys Asp Thr Leu Lys Lys
                  30                  35                  40

 atg cag aag ttc ttt gga ctg ccc cag aca ggt gat ctt gac cag aat      617
 Met Gln Lys Phe Phe Gly Leu Pro Gln Thr Gly Asp Leu Asp Gln Asn
              45                  50                  55

 acc atc gag acc atg cgg aag cca cgc tgc ggc aac cca gat gtg gcc      665
 Thr Ile Glu Thr Met Arg Lys Pro Arg Cys Gly Asn Pro Asp Val Ala
          60                  65                  70

 aac tac aac ttc ttc cct cgc aag ccc aag tgg gac aag aac cag atc      713
 Asn Tyr Asn Phe Phe Pro Arg Lys Pro Lys Trp Asp Lys Asn Gln Ile
      75                  80                  85

 aca tac agg atc att ggc tac aca cct gat ctg gac cca gag aca gtg      761
 Thr Tyr Arg Ile Ile Gly Tyr Thr Pro Asp Leu Asp Pro Glu Thr Val
  90                  95                 100                 105

 gat gat gcc ttt gct cgt gcc ttc caa gtc tgg agc gat gtg acc cca      809
 Asp Asp Ala Phe Ala Arg Ala Phe Gln Val Trp Ser Asp Val Thr Pro
                 110                 115                 120

 ctg cgg ttt tct cga atc cat gat gga gag gca gac atc atg atc aac      857
 Leu Arg Phe Ser Arg Ile His Asp Gly Glu Ala Asp Ile Met Ile Asn
             125                 130                 135

 ttt ggc cgc tgg gag cat ggc gat gga tac ccc ttt gac ggt aag gac      905
 Phe Gly Arg Trp Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp
         140                 145                 150

 gga ctc ctg gct cat gcc ttc gcc cca ggc act ggt gtt ggg gga gac      953
 Gly Leu Leu Ala His Ala Phe Ala Pro Gly Thr Gly Val Gly Gly Asp
     155                 160                 165

 tcc ctt ttc ttg aag att aac gtg cgt ttg caa ctg gat agc tct att     1001
 Ser Leu Phe Leu Lys Ile Asn Val Arg Leu Gln Leu Asp Ser Ser Ile
 170                 175                 180                 185

 gta cct tcc cgt aga atc cca gaa gtc taa c agcctgcctt catttttgtc     1052
 Val Pro Ser Arg Arg Ile Pro Glu Val 
                 190

 ctgtctcttt ctctattcag ttcaagctgg cagcat                             1088




      <210> 202
      <211> 2041
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (346)..(1674)

      <400> 202
 gcctttaatg ctttgatttg ccaggaactt caggtggctg tatggaaatg taaacctttg     60

 tatgaaggag tgtatcagtg cgtcagaact tggcacccac aaggatctta agaaaacagg    120

 ctatttgttc cttggagaaa ctattctcta atccaaaagt aaatgagaaa cttagaaaaa    180

 gattgccaat tccaaatcaa catatttaga gaaaattgga aaaggagaag cttactacag    240

 ctttatttga ggacttttta aagaacgctg ggttctatct gtgagctgca aatcttggag    300

 caaaaaccag agacattgcc agagcaaaca agaacagaaa tacaa    atg gag aac     354
                                                      Met Glu Asn
                                                        1

 tgg tca aaa gac ata acc cac agt tat ctt gaa caa gaa act acg ggg      402
 Trp Ser Lys Asp Ile Thr His Ser Tyr Leu Glu Gln Glu Thr Thr Gly
       5                  10                  15

 ata aat aaa agt acg cag cca gat gag caa ctg act atg aat tct gag      450
 Ile Asn Lys Ser Thr Gln Pro Asp Glu Gln Leu Thr Met Asn Ser Glu
  20                  25                  30                  35

 aaa agt atg cat cgg aaa tcc act gaa tta gtt aat gaa ata aca tgt      498
 Lys Ser Met His Arg Lys Ser Thr Glu Leu Val Asn Glu Ile Thr Cys
                  40                  45                  50

 gag aac aca gaa tgg cca ggg cag aga tca acg aat ttt cag atc atc      546
 Glu Asn Thr Glu Trp Pro Gly Gln Arg Ser Thr Asn Phe Gln Ile Ile
              55                  60                  65

 agt tct tat cca gat gat gag tct gtt tac tgc act act gaa aaa tac      594
 Ser Ser Tyr Pro Asp Asp Glu Ser Val Tyr Cys Thr Thr Glu Lys Tyr
          70                  75                  80

 aac gtt atg gaa cat aga cat aat gat atg cat tat gaa tgt atg act      642
 Asn Val Met Glu His Arg His Asn Asp Met His Tyr Glu Cys Met Thr
      85                  90                  95

 cct tgt caa gtt act tca gac tca gat aaa gag aag aca ata gca ttt      690
 Pro Cys Gln Val Thr Ser Asp Ser Asp Lys Glu Lys Thr Ile Ala Phe
 100                 105                 110                 115

 ctt cta aaa gaa ttg gat att ctc aga aca agc aat aaa aag ctt cag      738
 Leu Leu Lys Glu Leu Asp Ile Leu Arg Thr Ser Asn Lys Lys Leu Gln
                 120                 125                 130

 cag aaa ttg gct aaa gaa gat aaa gaa cag aga aaa cta aag ttt aag      786
 Gln Lys Leu Ala Lys Glu Asp Lys Glu Gln Arg Lys Leu Lys Phe Lys
             135                 140                 145

 ctg gaa ctc caa gag aaa gaa aca gaa gct aaa att gct gaa aag aca      834
 Leu Glu Leu Gln Glu Lys Glu Thr Glu Ala Lys Ile Ala Glu Lys Thr
         150                 155                 160

 gca gct ctg gtt gaa gaa gtg tat ttt gcg cag aag gaa cgt gat gaa      882
 Ala Ala Leu Val Glu Glu Val Tyr Phe Ala Gln Lys Glu Arg Asp Glu
     165                 170                 175

 gct gtt atg tct aga ctg caa tta gcc att gag gag aga gat gaa gca      930
 Ala Val Met Ser Arg Leu Gln Leu Ala Ile Glu Glu Arg Asp Glu Ala
 180                 185                 190                 195

 att gca cga gcc aag cat atg gaa atg tct cta aaa gtg cta gaa aat      978
 Ile Ala Arg Ala Lys His Met Glu Met Ser Leu Lys Val Leu Glu Asn
                 200                 205                 210

 att aac cct gaa gaa aat gac atg aca tta cag gaa tta ctg aac aga     1026
 Ile Asn Pro Glu Glu Asn Asp Met Thr Leu Gln Glu Leu Leu Asn Arg
             215                 220                 225

 ata aac aat gca gac aca ggg ata gct att cag aag aat gga gct ata     1074
 Ile Asn Asn Ala Asp Thr Gly Ile Ala Ile Gln Lys Asn Gly Ala Ile
         230                 235                 240

 att gtg gat aga atc tac aag acc aag gaa tgt aaa atg aga ata act     1122
 Ile Val Asp Arg Ile Tyr Lys Thr Lys Glu Cys Lys Met Arg Ile Thr
     245                 250                 255

 gca gaa gaa atg agt gca cta ata gaa gaa cgg gat gct gcc ttg tct     1170
 Ala Glu Glu Met Ser Ala Leu Ile Glu Glu Arg Asp Ala Ala Leu Ser
 260                 265                 270                 275

 aag tgc aaa cgg tta gag cag gag ctt cat cat gtg aaa gag cag aac     1218
 Lys Cys Lys Arg Leu Glu Gln Glu Leu His His Val Lys Glu Gln Asn
                 280                 285                 290

 cag act tca gca aac aac atg aga cat ctg act gct gaa aac aat caa     1266
 Gln Thr Ser Ala Asn Asn Met Arg His Leu Thr Ala Glu Asn Asn Gln
             295                 300                 305

 gaa cgt gct ctg aag gca aag ttg tta tct atg caa caa gcc aga gaa     1314
 Glu Arg Ala Leu Lys Ala Lys Leu Leu Ser Met Gln Gln Ala Arg Glu
         310                 315                 320

 act gca gtt caa cag tac aaa aaa ctg gaa gag gaa atc cag acc ctt     1362
 Thr Ala Val Gln Gln Tyr Lys Lys Leu Glu Glu Glu Ile Gln Thr Leu
     325                 330                 335

 cga gtt tac tac agt tta cac aaa tct tta tct caa gaa gaa aat ctg     1410
 Arg Val Tyr Tyr Ser Leu His Lys Ser Leu Ser Gln Glu Glu Asn Leu
 340                 345                 350                 355

 aag gat cag ttt aac tat acc ctt agt aca tat gaa gaa gct tta aaa     1458
 Lys Asp Gln Phe Asn Tyr Thr Leu Ser Thr Tyr Glu Glu Ala Leu Lys
                 360                 365                 370

 aac aga gag aac att gtt tcc atc act caa caa caa aat gag gaa ctg     1506
 Asn Arg Glu Asn Ile Val Ser Ile Thr Gln Gln Gln Asn Glu Glu Leu
             375                 380                 385

 gct act caa ctg caa caa gct ctg aca gag cga gca aat atg gaa tta     1554
 Ala Thr Gln Leu Gln Gln Ala Leu Thr Glu Arg Ala Asn Met Glu Leu
         390                 395                 400

 caa ctt caa cat gcc aga gag gcc tcc caa gtg gcc aat gaa aaa gtt     1602
 Gln Leu Gln His Ala Arg Glu Ala Ser Gln Val Ala Asn Glu Lys Val
     405                 410                 415

 caa aag ttg gaa agg ctg gtg gat gta ctg agg aag aag gtt gga acc     1650
 Gln Lys Leu Glu Arg Leu Val Asp Val Leu Arg Lys Lys Val Gly Thr
 420                 425                 430                 435

 ggg acc atg agg aca gtg atc tga ttgaaaaaaa acgacagtct ggggaagcga    1704
 Gly Thr Met Arg Thr Val Ile 
                 440

 tcacatctgg tgaccaggct gcttcattca acactgtgta aacaccaaag ccttaactta   1764

 gcaaacagtt gttagaagtg ggacactcca accacattcc aagctgagat aaaatcaaat   1824

 cacaaatgtt taaccacttt gctgctgact tgagttattt atccaaatat attaactata   1884

 gacttttccc aatgggtagc tttaaggtta cagcttattt ggtactattt tatatctaat   1944

 atcttaatat aaagttttta ctgggagata ttatagaaac tgggagagtg ggtgggaact   2004

 atcttacata tggcccttgc tgatcaaagg gcgcgag                            2041




      <210> 203
      <211> 945
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (91)..(603)

      <400> 203
 cggcgcggcg ccccctggag gccgcgggac ccctggccgg tccgcgcagg cgcagcgggg     60

 tcgcagggcg cggcgggttc cagcgcgggg     atg gcg ctg tcc gcg gag gac     111
                                      Met Ala Leu Ser Ala Glu Asp
                                        1               5

 cgg gcg ctg gtg cgc gcc ctg tgg aag aag ctg ggc agc aac gtc ggc      159
 Arg Ala Leu Val Arg Ala Leu Trp Lys Lys Leu Gly Ser Asn Val Gly
          10                  15                  20

 gtc tac acg aca gag gcc ctg gag agg tgc ggc agg ctg ggc gcc ccg      207
 Val Tyr Thr Thr Glu Ala Leu Glu Arg Cys Gly Arg Leu Gly Ala Pro
      25                  30                  35

 cgc gcc ctg tgg ccc aac ctg ggc agc ccc cgt cgg cgt cta cac gac      255
 Arg Ala Leu Trp Pro Asn Leu Gly Ser Pro Arg Arg Arg Leu His Asp
  40                  45                  50                  55

 aga ggc cct gga aag acc ttc ctg gct ttc ccc gcc acg aag acc tac      303
 Arg Gly Pro Gly Lys Thr Phe Leu Ala Phe Pro Ala Thr Lys Thr Tyr
                  60                  65                  70

 ttc tcc cac ctg gac ctg agc ccc ggc tcc tca caa gtc aga gcc cac      351
 Phe Ser His Leu Asp Leu Ser Pro Gly Ser Ser Gln Val Arg Ala His
              75                  80                  85

 ggc cag aag gtg gcg gac gcg ctg agc ctc gcc gtg gag cgc ctg gac      399
 Gly Gln Lys Val Ala Asp Ala Leu Ser Leu Ala Val Glu Arg Leu Asp
          90                  95                 100

 gac cta ccc cac gcg ctg tcc gcg ctg agc cac ctg cac gcg tgc cag      447
 Asp Leu Pro His Ala Leu Ser Ala Leu Ser His Leu His Ala Cys Gln
     105                 110                 115

 ctg cga gtg gac ccg gcc agc ttc cag ctc ctg ggc cac tgc ctg ctg      495
 Leu Arg Val Asp Pro Ala Ser Phe Gln Leu Leu Gly His Cys Leu Leu
 120                 125                 130                 135

 gta acc ctc gcc cgg cac tac ccc gga gac ttc agc ccc gcg ctg cag      543
 Val Thr Leu Ala Arg His Tyr Pro Gly Asp Phe Ser Pro Ala Leu Gln
                 140                 145                 150

 gcg tcg ctg gac aag ttc ctg agc cac gtt atc tcg gcg ctg gtt tcc      591
 Ala Ser Leu Asp Lys Phe Leu Ser His Val Ile Ser Ala Leu Val Ser
             155                 160                 165

 gag tac cgc tga act gtgggtgggt ggccgcggga tccccaggcg accttccccg      646
 Glu Tyr Arg 
         170

 tgtttgagta aagcctctcc caggagcagc cttcttgccg tgctctctcg agggcaggac    706

 gcgataggaa ggcgccgccc ctccccaagg aaaggcgagg gcctgtggca cacccccagt    766

 gcccaaatcc aggcgcgcct ctttccacct tcagcaggtt tggggcctcc gccatggggg    826

 cacctgaact gcgagcagcc tgaccctccc gaatggggtg gtaggtgagg gccgccggac    886

 accccggccg gcgggctgct aggatcgccg actctgccca ttccgagggc ggctgtctg     945




      <210> 204
      <211> 1395
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1395)

      <400> 204
  atg ctt cag gtc cca tgc cct aca gag gct gat att agt caa cac ctg      48
  Met Leu Gln Val Pro Cys Pro Thr Glu Ala Asp Ile Ser Gln His Leu
    1               5                  10                  15

 aca aac agg gag gtt ccc aac agc agt cag cgg cgg tac acg ggg aaa       96
 Thr Asn Arg Glu Val Pro Asn Ser Ser Gln Arg Arg Tyr Thr Gly Lys
              20                  25                  30

 gtt cct tgc aac cat ttc act ctc aac gag gaa gag gat tgc ttt aag      144
 Val Pro Cys Asn His Phe Thr Leu Asn Glu Glu Glu Asp Cys Phe Lys
          35                  40                  45

 gca ctg att tgg ata agg aat aac tcc atc acc aca gaa ggg aat atc      192
 Ala Leu Ile Trp Ile Arg Asn Asn Ser Ile Thr Thr Glu Gly Asn Ile
      50                  55                  60

 att gtc tat ggg aat aca att gat act tac acc acc gtg gag acg ctc      240
 Ile Val Tyr Gly Asn Thr Ile Asp Thr Tyr Thr Thr Val Glu Thr Leu
  65                  70                  75                  80

 tta aac ctt ggc gtg agc ggc agc cgc atc cac ctc gtg cag ccc ccg      288
 Leu Asn Leu Gly Val Ser Gly Ser Arg Ile His Leu Val Gln Pro Pro
                  85                  90                  95

 ccc gcc tcc acc atc acc tgc atc aac aac tac tcg gtg gag agc gcc      336
 Pro Ala Ser Thr Ile Thr Cys Ile Asn Asn Tyr Ser Val Glu Ser Ala
             100                 105                 110

 gtg gcg gac gcg cta gga gcc gcc gga gtc act atg tac cgg gat gcg      384
 Val Ala Asp Ala Leu Gly Ala Ala Gly Val Thr Met Tyr Arg Asp Ala
         115                 120                 125

 atc ctg gcc cag tgg aat gac ggc ctg cac cca gac ccc atc tac agc      432
 Ile Leu Ala Gln Trp Asn Asp Gly Leu His Pro Asp Pro Ile Tyr Ser
     130                 135                 140

 gcc tcc ttc acc aca ccc acc aag cct ttc aga ctc cag tgc tct atg      480
 Ala Ser Phe Thr Thr Pro Thr Lys Pro Phe Arg Leu Gln Cys Ser Met
 145                 150                 155                 160

 ttc ttc agc ttc tgt gag aag aat gtg gat tat gaa acg ttt aaa gcc      528
 Phe Phe Ser Phe Cys Glu Lys Asn Val Asp Tyr Glu Thr Phe Lys Ala
                 165                 170                 175

 ctc aat gat gca tgt ctt gtg tat gac agt cga ctt gtg att gat acc      576
 Leu Asn Asp Ala Cys Leu Val Tyr Asp Ser Arg Leu Val Ile Asp Thr
             180                 185                 190

 aac ttc cac acc aac gac ata gcc atc aga gct gct ggc tcc ctc acc      624
 Asn Phe His Thr Asn Asp Ile Ala Ile Arg Ala Ala Gly Ser Leu Thr
         195                 200                 205

 aaa ttc tcc aat aga tac tac tca aat gag tgg act cac agc aac ttc      672
 Lys Phe Ser Asn Arg Tyr Tyr Ser Asn Glu Trp Thr His Ser Asn Phe
     210                 215                 220

 agt tcc aaa gaa att ggc ttt cag ctg gca gca gct atg cta cat ctc      720
 Ser Ser Lys Glu Ile Gly Phe Gln Leu Ala Ala Ala Met Leu His Leu
 225                 230                 235                 240

 ttt gat cca acc ctt gag cct gtg acc gag cca cca gct aat ctt gac      768
 Phe Asp Pro Thr Leu Glu Pro Val Thr Glu Pro Pro Ala Asn Leu Asp
                 245                 250                 255

 cgg ctc atc ccc atg tac aag gga gcc aag att caa ggg ggc att ctt      816
 Arg Leu Ile Pro Met Tyr Lys Gly Ala Lys Ile Gln Gly Gly Ile Leu
             260                 265                 270

 cct ggg tct tac cat tat ctg cat att gcc aag cct gcc att cca act      864
 Pro Gly Ser Tyr His Tyr Leu His Ile Ala Lys Pro Ala Ile Pro Thr
         275                 280                 285

 ccc ttg gag gta caa atg gca cag cct aat tat ggt tta gaa cta gta      912
 Pro Leu Glu Val Gln Met Ala Gln Pro Asn Tyr Gly Leu Glu Leu Val
     290                 295                 300

 acc ggc agt gcg aaa aat ggg act tac ttc cga att cat att aac aag      960
 Thr Gly Ser Ala Lys Asn Gly Thr Tyr Phe Arg Ile His Ile Asn Lys
 305                 310                 315                 320

 tat aaa atg gtg gaa acc atc acg tgc ctt tct agg gag ccc ttc ccc     1008
 Tyr Lys Met Val Glu Thr Ile Thr Cys Leu Ser Arg Glu Pro Phe Pro
                 325                 330                 335

 gcc tcc aac tac atc cgc ttg ttt ggc cag cac gag caa ctc ctc aac     1056
 Ala Ser Asn Tyr Ile Arg Leu Phe Gly Gln His Glu Gln Leu Leu Asn
             340                 345                 350

 aac ctg tgt gct cgg tac gat gaa aac ctg atc aca gat ctc tat agc     1104
 Asn Leu Cys Ala Arg Tyr Asp Glu Asn Leu Ile Thr Asp Leu Tyr Ser
         355                 360                 365

 tac ttc acc gag ccg tgg tgc ctg gcc ctg ttc cac gat cgt ttt att     1152
 Tyr Phe Thr Glu Pro Trp Cys Leu Ala Leu Phe His Asp Arg Phe Ile
     370                 375                 380

 gat ctc agg aaa gag tta cgc caa atc tta gcc tcc aag gag gag gaa     1200
 Asp Leu Arg Lys Glu Leu Arg Gln Ile Leu Ala Ser Lys Glu Glu Glu
 385                 390                 395                 400

 gat ctt cct tcc ata gag cag tta gcc cat caa ata gaa gat gag gaa     1248
 Asp Leu Pro Ser Ile Glu Gln Leu Ala His Gln Ile Glu Asp Glu Glu
                 405                 410                 415

 atc aac ccg act gag aag ccc agg caa tac ctc aaa aga gtt ttt gag     1296
 Ile Asn Pro Thr Glu Lys Pro Arg Gln Tyr Leu Lys Arg Val Phe Glu
             420                 425                 430

 gaa tcc atc tac aaa acc ctg gtg gag aga agc act ctt gac tac ctg     1344
 Glu Ser Ile Tyr Lys Thr Leu Val Glu Arg Ser Thr Leu Asp Tyr Leu
         435                 440                 445

 cac tat aac cgc tac cac ctg ccc atg tac gcg tgg cca ggc atc gtt     1392
 His Tyr Asn Arg Tyr His Leu Pro Met Tyr Ala Trp Pro Gly Ile Val
     450                 455                 460

 tag                                                                 1395
 






      <210> 205
      <211> 399
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(399)

      <400> 205
  atg agg gaa gga cag gag atg ggg ccc acc cca gtg ccc agc aac ccc      48
  Met Arg Glu Gly Gln Glu Met Gly Pro Thr Pro Val Pro Ser Asn Pro
    1               5                  10                  15

 ctg ttc cac cgc tca ttc ccc tgc tgg ccc cgg ggc tgg ttt cac cca       96
 Leu Phe His Arg Ser Phe Pro Cys Trp Pro Arg Gly Trp Phe His Pro
              20                  25                  30

 gtg cca acc cga aag ctc ctt ttg gaa cct gca cag ccc gcc gac ctg      144
 Val Pro Thr Arg Lys Leu Leu Leu Glu Pro Ala Gln Pro Ala Asp Leu
          35                  40                  45

 ttg cca cct gca ccc ccc gct gga cca tgc agc ctc gcc tcc tgg atg      192
 Leu Pro Pro Ala Pro Pro Ala Gly Pro Cys Ser Leu Ala Ser Trp Met
      50                  55                  60

 ctg tcc cag cct ggc cga ggg tcc cag gtg aag act gga ggg acc cca      240
 Leu Ser Gln Pro Gly Arg Gly Ser Gln Val Lys Thr Gly Gly Thr Pro
  65                  70                  75                  80

 aca gcc ccc gcc cag gac gct gag gct ccc ttg cct gac tgt gac ttg      288
 Thr Ala Pro Ala Gln Asp Ala Glu Ala Pro Leu Pro Asp Cys Asp Leu
                  85                  90                  95

 tgc ctt ttt cct gcc ccc gtg ggg aca tgg cag ccc aaa gcc aag gct      336
 Cys Leu Phe Pro Ala Pro Val Gly Thr Trp Gln Pro Lys Ala Lys Ala
             100                 105                 110

 ggg tgg gca ggt gac cca agg aac ctt ttt ggg aac ccc ttt tcg ccg      384
 Gly Trp Ala Gly Asp Pro Arg Asn Leu Phe Gly Asn Pro Phe Ser Pro
         115                 120                 125

 ggc tgg gaa caa taa                                                  399
 Gly Trp Glu Gln 
     130





      <210> 206
      <211> 3135
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3135)

      <400> 206
  atg gag ggc cag agc agc agg ggc agc agg agg cca ggg acc cgg gct      48
  Met Glu Gly Gln Ser Ser Arg Gly Ser Arg Arg Pro Gly Thr Arg Ala
    1               5                  10                  15

 ggc ctg ggt tcc ctg ccc atg ccc cag ggt gtt gcc caa act ggg gca       96
 Gly Leu Gly Ser Leu Pro Met Pro Gln Gly Val Ala Gln Thr Gly Ala
              20                  25                  30

 ccc tcc aag gtg gac tca agt ttt cag ctc cca gca aag aag aac gca      144
 Pro Ser Lys Val Asp Ser Ser Phe Gln Leu Pro Ala Lys Lys Asn Ala
          35                  40                  45

 gcc cta gga ccc tcg gaa cca agg ttg gct ctg gca cct gta ggg cca      192
 Ala Leu Gly Pro Ser Glu Pro Arg Leu Ala Leu Ala Pro Val Gly Pro
      50                  55                  60

 cgg gca gct atg tca gct tcc tcg gaa gga ccg agg ctg gct ctg gca      240
 Arg Ala Ala Met Ser Ala Ser Ser Glu Gly Pro Arg Leu Ala Leu Ala
  65                  70                  75                  80

 tct ccc cga cca atc ctg gct cca ctg tgt acc cct gaa ggg cag aaa      288
 Ser Pro Arg Pro Ile Leu Ala Pro Leu Cys Thr Pro Glu Gly Gln Lys
                  85                  90                  95

 aca gct act gcc cac cgc agc tcc agc ctg gcc cca aca tct gtg ggc      336
 Thr Ala Thr Ala His Arg Ser Ser Ser Leu Ala Pro Thr Ser Val Gly
             100                 105                 110

 cag ctg gtg atg tct gcc tca gct gga cca aag cct ccc cca gcg acc      384
 Gln Leu Val Met Ser Ala Ser Ala Gly Pro Lys Pro Pro Pro Ala Thr
         115                 120                 125

 aca ggc tca gtt ctg gct ccg acg tcc ctg ggg ctg gtg atg cct gcc      432
 Thr Gly Ser Val Leu Ala Pro Thr Ser Leu Gly Leu Val Met Pro Ala
     130                 135                 140

 tca gca ggg cca aga tct ccc cca gtc acc ctg ggg ccc aat ctg gcc      480
 Ser Ala Gly Pro Arg Ser Pro Pro Val Thr Leu Gly Pro Asn Leu Ala
 145                 150                 155                 160

 cca acc tcc aga gac cag aag cag gag cca cct gcc tcc gtg gga ccc      528
 Pro Thr Ser Arg Asp Gln Lys Gln Glu Pro Pro Ala Ser Val Gly Pro
                 165                 170                 175

 aag cca aca ctg gca gcc tct ggc ctg agc ctg gcc ctg gct tct gag      576
 Lys Pro Thr Leu Ala Ala Ser Gly Leu Ser Leu Ala Leu Ala Ser Glu
             180                 185                 190

 gag cag ccc cca gaa ctc ccc tcc acc cct tcc ccg gtg ccc agt cca      624
 Glu Gln Pro Pro Glu Leu Pro Ser Thr Pro Ser Pro Val Pro Ser Pro
         195                 200                 205

 gtt ctg tct cca act cag gaa cag gcc ctg gct cca gca tcc acg gca      672
 Val Leu Ser Pro Thr Gln Glu Gln Ala Leu Ala Pro Ala Ser Thr Ala
     210                 215                 220

 tca ggc gca gcc tct gtg gga cag aca tca gct aga aag agg gat gcc      720
 Ser Gly Ala Ala Ser Val Gly Gln Thr Ser Ala Arg Lys Arg Asp Ala
 225                 230                 235                 240

 cca gcc cct aga cct ctc cct gct tct gag ggg cat ctc cag cct cca      768
 Pro Ala Pro Arg Pro Leu Pro Ala Ser Glu Gly His Leu Gln Pro Pro
                 245                 250                 255

 gct cag aca tct ggt cct aca ggc tcc cca ccc tgc atc caa acc tcc      816
 Ala Gln Thr Ser Gly Pro Thr Gly Ser Pro Pro Cys Ile Gln Thr Ser
             260                 265                 270

 cca gac cct cgg ctc tcc ccc tcc ttc cga gcc cgg cct gag gcc ctc      864
 Pro Asp Pro Arg Leu Ser Pro Ser Phe Arg Ala Arg Pro Glu Ala Leu
         275                 280                 285

 cac agc agc cct gag gat cct gtt ttg cca cgg cca ccc cag acc ttg      912
 His Ser Ser Pro Glu Asp Pro Val Leu Pro Arg Pro Pro Gln Thr Leu
     290                 295                 300

 ccc ttg gat gtg ggc cag ggt cct tca gag cct ggc act cac tcc cct      960
 Pro Leu Asp Val Gly Gln Gly Pro Ser Glu Pro Gly Thr His Ser Pro
 305                 310                 315                 320

 gga ctt ctg tcc ccc acc ttc cgg cct ggg gcc ccc tca ggc cag act     1008
 Gly Leu Leu Ser Pro Thr Phe Arg Pro Gly Ala Pro Ser Gly Gln Thr
                 325                 330                 335

 gtg ccc cca cct ctg ccc aag cca ccc cga tca ccc agc cgt tcc cca     1056
 Val Pro Pro Pro Leu Pro Lys Pro Pro Arg Ser Pro Ser Arg Ser Pro
             340                 345                 350

 agc cac tcc ccg aat cgc tct ccc tgt gtt ccc cca gcc cct gac atg     1104
 Ser His Ser Pro Asn Arg Ser Pro Cys Val Pro Pro Ala Pro Asp Met
         355                 360                 365

 gcc ctc cca agg ctt ggc acc cag agt aca ggg cct ggc agg tgc ctg     1152
 Ala Leu Pro Arg Leu Gly Thr Gln Ser Thr Gly Pro Gly Arg Cys Leu
     370                 375                 380

 agc ccc aac ctt cag gcc caa gaa gcc cca gcc cca gtc acc acc tcc     1200
 Ser Pro Asn Leu Gln Ala Gln Glu Ala Pro Ala Pro Val Thr Thr Ser
 385                 390                 395                 400

 tct tct aca tcc acc ctg tca tcc tcc cct tgg tca gct cag cct acc     1248
 Ser Ser Thr Ser Thr Leu Ser Ser Ser Pro Trp Ser Ala Gln Pro Thr
                 405                 410                 415

 tgg aag agc gac ccc ggc ttc cgg atc act gtg gtc aca tgg aac gtg     1296
 Trp Lys Ser Asp Pro Gly Phe Arg Ile Thr Val Val Thr Trp Asn Val
             420                 425                 430

 ggc act gcc atg ccc cca gac gat gtc aca tcc ctc ctc cac ctg ggc     1344
 Gly Thr Ala Met Pro Pro Asp Asp Val Thr Ser Leu Leu His Leu Gly
         435                 440                 445

 ggt ggt gac gac agc gac ggc gca gac atg atc gcc ata ggg ttg cag     1392
 Gly Gly Asp Asp Ser Asp Gly Ala Asp Met Ile Ala Ile Gly Leu Gln
     450                 455                 460

 gaa gtg aac tcc atg ctc aac aag cga ctc aag gac gcc ctc ttc acg     1440
 Glu Val Asn Ser Met Leu Asn Lys Arg Leu Lys Asp Ala Leu Phe Thr
 465                 470                 475                 480

 gac cag tgg agt gag ctg ttc atg aat gcg cta ggg ccc ttc aac ttc     1488
 Asp Gln Trp Ser Glu Leu Phe Met Asn Ala Leu Gly Pro Phe Asn Phe
                 485                 490                 495

 gtg ctg gta acg cac ccc tca ccc cct gga cag cca gag acc ctg ctg     1536
 Val Leu Val Thr His Pro Ser Pro Pro Gly Gln Pro Glu Thr Leu Leu
             500                 505                 510

 aat tcc tgg ctc cag ctg tac cct ggc tca ctg tgg ggc ccg ctg ggc     1584
 Asn Ser Trp Leu Gln Leu Tyr Pro Gly Ser Leu Trp Gly Pro Leu Gly
         515                 520                 525

 ctc tgt ggc tgg gtg agt tcg gtg agg atg cag ggt gtc atc ctg ctg     1632
 Leu Cys Gly Trp Val Ser Ser Val Arg Met Gln Gly Val Ile Leu Leu
     530                 535                 540

 ctg ttc gcc aag tac tac cac ctg ccc ttc ctg cga gac gtg cag acc     1680
 Leu Phe Ala Lys Tyr Tyr His Leu Pro Phe Leu Arg Asp Val Gln Thr
 545                 550                 555                 560

 gac tgc acg cgc act ggc ctg ggc ggc tac tgg ggt aac aag ggt ggc     1728
 Asp Cys Thr Arg Thr Gly Leu Gly Gly Tyr Trp Gly Asn Lys Gly Gly
                 565                 570                 575

 gtg agc gtg cgc ctg gcg gcc ttc ggg cac atg ctc tgc ttc ctg aac     1776
 Val Ser Val Arg Leu Ala Ala Phe Gly His Met Leu Cys Phe Leu Asn
             580                 585                 590

 tgc cac ttg cct gcg cat atg gac aag gcg gag cag cgc aaa gac aac     1824
 Cys His Leu Pro Ala His Met Asp Lys Ala Glu Gln Arg Lys Asp Asn
         595                 600                 605

 ttc cag acc atc ctc agc ctc cag cag ttc caa ggg ccg ggc gca cag     1872
 Phe Gln Thr Ile Leu Ser Leu Gln Gln Phe Gln Gly Pro Gly Ala Gln
     610                 615                 620

 ggc atc ctg gat cat gag tat ggg ctg ggc ctc gtg ttc tgg ttc ggg     1920
 Gly Ile Leu Asp His Glu Tyr Gly Leu Gly Leu Val Phe Trp Phe Gly
 625                 630                 635                 640

 gac ctg aac ttc cgc att gag agc tat gac ctg cac ttt gtc aag ttt     1968
 Asp Leu Asn Phe Arg Ile Glu Ser Tyr Asp Leu His Phe Val Lys Phe
                 645                 650                 655

 gcc atc gac agt gac cag ctc cat cag ctc tgg gag aag gac cag ctc     2016
 Ala Ile Asp Ser Asp Gln Leu His Gln Leu Trp Glu Lys Asp Gln Leu
             660                 665                 670

 aac atg gcc aag aac acc tgg ccc att ctg aag ggc ttt cag gag ggg     2064
 Asn Met Ala Lys Asn Thr Trp Pro Ile Leu Lys Gly Phe Gln Glu Gly
         675                 680                 685

 ccc ctc aac ttc gct ccc acc ttc aag ttt gat gtg ggt acc aac aaa     2112
 Pro Leu Asn Phe Ala Pro Thr Phe Lys Phe Asp Val Gly Thr Asn Lys
     690                 695                 700

 tac gat acc agt gcc aag aaa cgg aag cca gct tgg aca gac cgt atc     2160
 Tyr Asp Thr Ser Ala Lys Lys Arg Lys Pro Ala Trp Thr Asp Arg Ile
 705                 710                 715                 720

 cta tgg aag gtc aag gct cca ggt ggg ggt ccc agc ccc tca gga cgg     2208
 Leu Trp Lys Val Lys Ala Pro Gly Gly Gly Pro Ser Pro Ser Gly Arg
                 725                 730                 735

 aag agc cac cga ctc cag gtg acg cag cac agc tac cgc agc cac atg     2256
 Lys Ser His Arg Leu Gln Val Thr Gln His Ser Tyr Arg Ser His Met
             740                 745                 750

 gaa tac aca gtc agc gac cac aag cct gtg gct gcc cag ttc ctc ctg     2304
 Glu Tyr Thr Val Ser Asp His Lys Pro Val Ala Ala Gln Phe Leu Leu
         755                 760                 765

 cag ttt gcc ttc agg gac gac atg cca ctg gtg cgg ctg gag gtg gca     2352
 Gln Phe Ala Phe Arg Asp Asp Met Pro Leu Val Arg Leu Glu Val Ala
     770                 775                 780

 gat gag tgg gtg cgg ccc gag cag gcg gtg gtg agg tac cgc atg gaa     2400
 Asp Glu Trp Val Arg Pro Glu Gln Ala Val Val Arg Tyr Arg Met Glu
 785                 790                 795                 800

 aca gtg ttc gcc cgc agc tcc tgg gac tgg atc ggc tta tac cgg gtg     2448
 Thr Val Phe Ala Arg Ser Ser Trp Asp Trp Ile Gly Leu Tyr Arg Val
                 805                 810                 815

 ggt ttc cgc cat tgc aag gac tat gtg gct tat gtc tgg gcc aaa cat     2496
 Gly Phe Arg His Cys Lys Asp Tyr Val Ala Tyr Val Trp Ala Lys His
             820                 825                 830

 gaa gat gtg gat ggg aat acc tac cag gta aca ttc agt gag gaa tca     2544
 Glu Asp Val Asp Gly Asn Thr Tyr Gln Val Thr Phe Ser Glu Glu Ser
         835                 840                 845

 ctg ccc aag ggc cat gga gac ttc atc ctg ggc tac tat agt cac aac     2592
 Leu Pro Lys Gly His Gly Asp Phe Ile Leu Gly Tyr Tyr Ser His Asn
     850                 855                 860

 cac agc atc ctc atc ggc atc act gaa ccc ttc cag atc tcg ctg cct     2640
 His Ser Ile Leu Ile Gly Ile Thr Glu Pro Phe Gln Ile Ser Leu Pro
 865                 870                 875                 880

 tcc tcg gag ttg gcc agc agc agc aca gac agc tca ggc acc agc tca     2688
 Ser Ser Glu Leu Ala Ser Ser Ser Thr Asp Ser Ser Gly Thr Ser Ser
                 885                 890                 895

 gag gga gag gat gac agc aca ctg gag ctc ctt gca ccc aag tcc cgc     2736
 Glu Gly Glu Asp Asp Ser Thr Leu Glu Leu Leu Ala Pro Lys Ser Arg
             900                 905                 910

 agc ccc agt cct ggc aag tcc aag cga cac cgc agc cgc agc ccg gga     2784
 Ser Pro Ser Pro Gly Lys Ser Lys Arg His Arg Ser Arg Ser Pro Gly
         915                 920                 925

 ctg gcc agg ttc cct ggg ctt gcc cta cgg ccc tca tcc cgt gaa cgc     2832
 Leu Ala Arg Phe Pro Gly Leu Ala Leu Arg Pro Ser Ser Arg Glu Arg
     930                 935                 940

 cgt ggt gcc agc cgt agc ccc tca ccc cag agc cgc cgc ctg tcc cga     2880
 Arg Gly Ala Ser Arg Ser Pro Ser Pro Gln Ser Arg Arg Leu Ser Arg
 945                 950                 955                 960

 gtg gct cct gac agg agc agt aat ggc agc agc cgg ggc agt agt gaa     2928
 Val Ala Pro Asp Arg Ser Ser Asn Gly Ser Ser Arg Gly Ser Ser Glu
                 965                 970                 975

 gag ggg ccc tct ggg ttg cct ggc ccc tgg gcc ttc cca cca gct gtg     2976
 Glu Gly Pro Ser Gly Leu Pro Gly Pro Trp Ala Phe Pro Pro Ala Val
             980                 985                 990

 cct cga agc ctg ggc ctg ttg ccc gcc ttg cgc cta gag act gta gac     3024
 Pro Arg Ser Leu Gly Leu Leu Pro Ala Leu Arg Leu Glu Thr Val Asp
         995                1000                1005

 cct ggt ggt ggt ggc tcc tgg gga cct gat cgg gag gcc ctg gcg ccc     3072
 Pro Gly Gly Gly Gly Ser Trp Gly Pro Asp Arg Glu Ala Leu Ala Pro
    1010                1015                1020

 aac agc ctg tct cct agt ccc cag ggc cat cgg ggg ctg gag gaa ggg     3120
 Asn Ser Leu Ser Pro Ser Pro Gln Gly His Arg Gly Leu Glu Glu Gly
1025                1030                1035                1040

 ggc ctg ggg ccc tga                                                 3135
 Gly Leu Gly Pro 






      <210> 207
      <211> 495
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(495)

      <400> 207
  atg gac cct ggc aac cct ggt tcg agc ccc agg tgc gcc tcg cgc ccg      48
  Met Asp Pro Gly Asn Pro Gly Ser Ser Pro Arg Cys Ala Ser Arg Pro
    1               5                  10                  15

 cta ggg tta ccc aga agc cgg cag aag gcc cat gag agg aag gtg aga       96
 Leu Gly Leu Pro Arg Ser Arg Gln Lys Ala His Glu Arg Lys Val Arg
              20                  25                  30

 cac ctg ggg caa agg aaa aaa aaa aaa ccg cgc tgc ata gaa gcg ggg      144
 His Leu Gly Gln Arg Lys Lys Lys Lys Pro Arg Cys Ile Glu Ala Gly
          35                  40                  45

 cct ggc tcc tcc acg gac gaa ggt gcc ttc cca tca gcc cct gcg ctg      192
 Pro Gly Ser Ser Thr Asp Glu Gly Ala Phe Pro Ser Ala Pro Ala Leu
      50                  55                  60

 ggc ctt ggg gaa cct ggt gtc cct ggc tgg aaa cca ggg tgc acc tcg      240
 Gly Leu Gly Glu Pro Gly Val Pro Gly Trp Lys Pro Gly Cys Thr Ser
  65                  70                  75                  80

 gac ccg cta ggg gta ccc caa gga gag cag aaa gcc cat gag ggg aag      288
 Asp Pro Leu Gly Val Pro Gln Gly Glu Gln Lys Ala His Glu Gly Lys
                  85                  90                  95

 gtg agg cac ctg cgg cag aga aag aag aaa aac cgc gcc gtg gag aag      336
 Val Arg His Leu Arg Gln Arg Lys Lys Lys Asn Arg Ala Val Glu Lys
             100                 105                 110

 cgg ggc ctg ggt ccc cca ctg acg aaa gtg tct ttc cgt cag ccc ttg      384
 Arg Gly Leu Gly Pro Pro Leu Thr Lys Val Ser Phe Arg Gln Pro Leu
         115                 120                 125

 agc tgg gtc ccg agg acg ctg aca tca ctg gtt cga gcc cac gcc gtg      432
 Ser Trp Val Pro Arg Thr Leu Thr Ser Leu Val Arg Ala His Ala Val
     130                 135                 140

 cct cag gct gct acg agt acc cca agg agg aaa gaa ggc cca aaa gtt      480
 Pro Gln Ala Ala Thr Ser Thr Pro Arg Arg Lys Glu Gly Pro Lys Val
 145                 150                 155                 160

 tca gct gag gtt tga                                                  495
 Ser Ala Glu Val 






      <210> 208
      <211> 1176
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1176)

      <400> 208
  atg aac acc aac cct tcc cga ggc ccc tac cac ttc cgg gcc ccc agc      48
  Met Asn Thr Asn Pro Ser Arg Gly Pro Tyr His Phe Arg Ala Pro Ser
    1               5                  10                  15

 cgc atc ttc tgg cgg acc gtg cga ggt atg ctg ccc cac aaa acc aag       96
 Arg Ile Phe Trp Arg Thr Val Arg Gly Met Leu Pro His Lys Thr Lys
              20                  25                  30

 cga ggc cag gcc gct ctg gac cgt ctc aag gtg ttt gac ggc atc cca      144
 Arg Gly Gln Ala Ala Leu Asp Arg Leu Lys Val Phe Asp Gly Ile Pro
          35                  40                  45

 ccg ccc tac gac aag aaa aag cgg atg gtg gtt cct gct gcc ctc aag      192
 Pro Pro Tyr Asp Lys Lys Lys Arg Met Val Val Pro Ala Ala Leu Lys
      50                  55                  60

 gtc gtg cgt ctg aag cct aca aga aag ttt gcc tat ctg ggg cgc ctg      240
 Val Val Arg Leu Lys Pro Thr Arg Lys Phe Ala Tyr Leu Gly Arg Leu
  65                  70                  75                  80

 gct cac gag gtt ggc tgg aag tac cag gca gtg aca gcc acc ctg gag      288
 Ala His Glu Val Gly Trp Lys Tyr Gln Ala Val Thr Ala Thr Leu Glu
                  85                  90                  95

 gag ccg cgg agc cgg ctc act gca cta ccc ccg ccc cct tct ttc ctc      336
 Glu Pro Arg Ser Arg Leu Thr Ala Leu Pro Pro Pro Pro Ser Phe Leu
             100                 105                 110

 cag acg ccg aag tcg cgg gcg ctc atg gcg ggc ctg gag gta ctg ttc      384
 Gln Thr Pro Lys Ser Arg Ala Leu Met Ala Gly Leu Glu Val Leu Phe
         115                 120                 125

 gca tcg gca gcg ccg gcc atc acc tgc agg cag gac gcg ctc gtc tgc      432
 Ala Ser Ala Ala Pro Ala Ile Thr Cys Arg Gln Asp Ala Leu Val Cys
     130                 135                 140

 ttc ttg cat tgg gaa gtg gtg aca cac ggt tac ttc ggc ttg ggt gtc      480
 Phe Leu His Trp Glu Val Val Thr His Gly Tyr Phe Gly Leu Gly Val
 145                 150                 155                 160

 ggt gac cag ccg ggt ccc aat gat aag aag tca gaa ctg ctg cca gct      528
 Gly Asp Gln Pro Gly Pro Asn Asp Lys Lys Ser Glu Leu Leu Pro Ala
                 165                 170                 175

 ggg tgg aac aac aat aaa gac ctg tat gtc ctc cgg tat gag tat aag      576
 Gly Trp Asn Asn Asn Lys Asp Leu Tyr Val Leu Arg Tyr Glu Tyr Lys
             180                 185                 190

 gat ggg tcc aga aag ctc ctt gtg aaa gcc atc acc gtg gag agc agc      624
 Asp Gly Ser Arg Lys Leu Leu Val Lys Ala Ile Thr Val Glu Ser Ser
         195                 200                 205

 atg atc ctc aat gtg ctg gaa tat ggc tca cag caa gtg gca gac ttg      672
 Met Ile Leu Asn Val Leu Glu Tyr Gly Ser Gln Gln Val Ala Asp Leu
     210                 215                 220

 acc ctg aac ttg gat gat tat atc gat gca gaa cac ctg ggt gac ttc      720
 Thr Leu Asn Leu Asp Asp Tyr Ile Asp Ala Glu His Leu Gly Asp Phe
 225                 230                 235                 240

 cac agg acc tac aag aac agt gag gag ctt cgg tct cgt att gtg tct      768
 His Arg Thr Tyr Lys Asn Ser Glu Glu Leu Arg Ser Arg Ile Val Ser
                 245                 250                 255

 gga atc atc aca cct atc cat gag cag tgg gaa aag gct aat gta agc      816
 Gly Ile Ile Thr Pro Ile His Glu Gln Trp Glu Lys Ala Asn Val Ser
             260                 265                 270

 agt ccc cac cgg gag ttc ccc cct gct acc gcc aga gag gtg gac cca      864
 Ser Pro His Arg Glu Phe Pro Pro Ala Thr Ala Arg Glu Val Asp Pro
         275                 280                 285

 ctc cgg att cct cca cgc cac cca cac acc agt cgg cag cct ccc tgg      912
 Leu Arg Ile Pro Pro Arg His Pro His Thr Ser Arg Gln Pro Pro Trp
     290                 295                 300

 tgt gat ccc ctg ggc ccg ttt gtt gtc ggg gga gaa gac tta gac cct      960
 Cys Asp Pro Leu Gly Pro Phe Val Val Gly Gly Glu Asp Leu Asp Pro
 305                 310                 315                 320

 ttt ggg cct cgg aga ggt ggc atg att gtg gat ccc ctg aga tct ggc     1008
 Phe Gly Pro Arg Arg Gly Gly Met Ile Val Asp Pro Leu Arg Ser Gly
                 325                 330                 335

 ttc cca aga gca ctt att gac cct tcc tca ggc ctc ccg aac cga ctt     1056
 Phe Pro Arg Ala Leu Ile Asp Pro Ser Ser Gly Leu Pro Asn Arg Leu
             340                 345                 350

 cct cca ggc gct gtg ccc cca gga gct cgc ttt gac ccc ttt gga ccc     1104
 Pro Pro Gly Ala Val Pro Pro Gly Ala Arg Phe Asp Pro Phe Gly Pro
         355                 360                 365

 att ggg acc agc cca ccc gga cct aac cca gac cat ctc ccc ccg ccg     1152
 Ile Gly Thr Ser Pro Pro Gly Pro Asn Pro Asp His Leu Pro Pro Pro
     370                 375                 380

 ggc tac gat gac atg tac ctg tga                                     1176
 Gly Tyr Asp Asp Met Tyr Leu 
 385                 390





      <210> 209
      <211> 811
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (62)..(565)

      <400> 209
 ggtgactgtg aggaaggtgt gtgtccaccg agcacttgga ttcagcttct tcatttccaa     60

 c    atg gaa gaa act tac acc gac tcc ctg gac cct gag aag cta ttg     106
      Met Glu Glu Thr Tyr Thr Asp Ser Leu Asp Pro Glu Lys Leu Leu
        1               5                  10                  15

 caa tgc ccc tat gac aaa aac cat caa atc agg gct tgc agg ttt cct      154
 Gln Cys Pro Tyr Asp Lys Asn His Gln Ile Arg Ala Cys Arg Phe Pro
                  20                  25                  30

 tat cat ctt atc aag tgc aga aag aat cat cct gat gtt gca agc aaa      202
 Tyr His Leu Ile Lys Cys Arg Lys Asn His Pro Asp Val Ala Ser Lys
              35                  40                  45

 ttg gct act tgt ccc ttc aat gct cgc cac cag gtt cct cga gct gaa      250
 Leu Ala Thr Cys Pro Phe Asn Ala Arg His Gln Val Pro Arg Ala Glu
          50                  55                  60

 att agt cat cat atc tca agc tgt gat gac aga agt tgt att gag caa      298
 Ile Ser His His Ile Ser Ser Cys Asp Asp Arg Ser Cys Ile Glu Gln
      65                  70                  75

 gat gtt gtc aac caa acc agg agc ctt aga caa gag act ctg gct gag      346
 Asp Val Val Asn Gln Thr Arg Ser Leu Arg Gln Glu Thr Leu Ala Glu
  80                  85                  90                  95

 agc act tgg cag tgc cct cct tgc gat gaa gac tgg gat aaa gat ttg      394
 Ser Thr Trp Gln Cys Pro Pro Cys Asp Glu Asp Trp Asp Lys Asp Leu
                 100                 105                 110

 tgg gag cag acc agc acc cca ttt gtc tgg ggc aca act cac tac tct      442
 Trp Glu Gln Thr Ser Thr Pro Phe Val Trp Gly Thr Thr His Tyr Ser
             115                 120                 125

 gac aac aac agc cct gcg agc aac ata gtt aca gaa cat aag aat aac      490
 Asp Asn Asn Ser Pro Ala Ser Asn Ile Val Thr Glu His Lys Asn Asn
         130                 135                 140

 ctg gct tca ggc atg cga gtt ccc aaa tct ctg ccg tat gtt ctg cca      538
 Leu Ala Ser Gly Met Arg Val Pro Lys Ser Leu Pro Tyr Val Leu Pro
     145                 150                 155

 tgg aaa aac aat gga aat gca cag taa ctgaa tacctatctc atcaaatgcc      590
 Trp Lys Asn Asn Gly Asn Ala Gln 
 160                 165

 agaccctaga agactgttgc ttcttcttct accagtgggt tctcattttc ctcctaatct    650

 aattatagaa tggtaaactc cctgtgactt tccaaactga caagcacact tttttcctcc    710

 ccccttgaat cctcatttaa tgcaagaacc ctcatactca gaagcttcca aataaacctt    770

 tgatacagat tgcttaaaaa aaaaaaaaaa aaaaaagatt t                        811




      <210> 210
      <211> 2415
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (18)..(809)

      <400> 210
 aaaccagaat ccgggca   atg gat aag gat gcc aag aaa aga atc cat aat      50
                      Met Asp Lys Asp Ala Lys Lys Arg Ile His Asn
                        1               5                  10

 ttc tct gtc atc aat cct gtt cct gga caa gct ata act cag att ttt       98
 Phe Ser Val Ile Asn Pro Val Pro Gly Gln Ala Ile Thr Gln Ile Phe
              15                  20                  25

 gca gtt gac aat aga gaa gat ctt cag aag tgg atg gaa gcc ttc tgg      146
 Ala Val Asp Asn Arg Glu Asp Leu Gln Lys Trp Met Glu Ala Phe Trp
          30                  35                  40

 cag cat ttc ttt gat ctt agc caa tgg aag cac tgt tgt gaa gaa ctt      194
 Gln His Phe Phe Asp Leu Ser Gln Trp Lys His Cys Cys Glu Glu Leu
      45                  50                  55

 atg aaa att gag att atg tca cca cgg aaa cca cct ttg ttc ttg aca      242
 Met Lys Ile Glu Ile Met Ser Pro Arg Lys Pro Pro Leu Phe Leu Thr
  60                  65                  70                  75

 aaa gag gca acc tca gtc tac cat gat atg agc att gat tca cct atg      290
 Lys Glu Ala Thr Ser Val Tyr His Asp Met Ser Ile Asp Ser Pro Met
                  80                  85                  90

 aaa ctt gaa agt tta acg gat ata ata caa aaa aaa att gaa gag aca      338
 Lys Leu Glu Ser Leu Thr Asp Ile Ile Gln Lys Lys Ile Glu Glu Thr
              95                 100                 105

 aat ggg cag ttc ctt att ggt cag cgt gaa gaa tcc tta cca cct cct      386
 Asn Gly Gln Phe Leu Ile Gly Gln Arg Glu Glu Ser Leu Pro Pro Pro
         110                 115                 120

 tgg gcc aca ctc ttt gat ggt aac cat caa atg gtc atc cag aaa aag      434
 Trp Ala Thr Leu Phe Asp Gly Asn His Gln Met Val Ile Gln Lys Lys
     125                 130                 135

 gta ctg tat cct gca agt gag cca tta cat gat gaa aaa ggg aaa aag      482
 Val Leu Tyr Pro Ala Ser Glu Pro Leu His Asp Glu Lys Gly Lys Lys
 140                 145                 150                 155

 aga caa gct ccc ctt cct cct tct gat aaa ctt cca ttc agc tta aaa      530
 Arg Gln Ala Pro Leu Pro Pro Ser Asp Lys Leu Pro Phe Ser Leu Lys
                 160                 165                 170

 tca cag agt aac aca gat caa ttg gtt aag gac aac tgg gga aaa aca      578
 Ser Gln Ser Asn Thr Asp Gln Leu Val Lys Asp Asn Trp Gly Lys Thr
             175                 180                 185

 agt gta tct cag aca tcg tct ttg gat acc aaa cta tca act cta atg      626
 Ser Val Ser Gln Thr Ser Ser Leu Asp Thr Lys Leu Ser Thr Leu Met
         190                 195                 200

 cat cac tta cag aaa cca atg gct gct cct cga aaa ctt ctg cct gcc      674
 His His Leu Gln Lys Pro Met Ala Ala Pro Arg Lys Leu Leu Pro Ala
     205                 210                 215

 agg aga aat aga tta agt gat ggt gag cac aca gac act aaa acc aat      722
 Arg Arg Asn Arg Leu Ser Asp Gly Glu His Thr Asp Thr Lys Thr Asn
 220                 225                 230                 235

 ttt gaa gcc aag cca gtg cca gct cca agg cag aaa tcc atc aaa gac      770
 Phe Glu Ala Lys Pro Val Pro Ala Pro Arg Gln Lys Ser Ile Lys Asp
                 240                 245                 250

 att ctg gac cct aga tca tgg ctg cag gca caa gta tag aaaactctta       819
 Ile Leu Asp Pro Arg Ser Trp Leu Gln Ala Gln Val 
             255                 260

 atgataaaac atttaacaaa atctataact gtgaagctta attcagaggc attatagaat    879

 aatgtgtaat tatataggta aatatagtga tttataccaa taattaataa gctattaggt    939

 atagaaaaac attttataat gaagaagtgg atttctcttt ttactcctga ttttgcagaa    999

 tgtaagtgat ttctccagca gtgtgcaaga ggcagtttct agacaatatc ctaatgtcgg   1059

 acagggttac tcctatcctg aattagtacc aggcagtgaa taagccctag gcagactaaa   1119

 gcattaaaat ttctttgggg agagactgtc tagtcattta caacatgtcg cacactatga   1179

 accatattct cattgtgcgc aatctcaata ctaaatggaa atgtttcaaa agggtcaact   1239

 tcaaaccaga aagtgataga atacagcgca ggaaaatttc cttagcattc tggaattctc   1299

 atctaatggt tcactggctc tcatctattg tttaactcac tagtttatag gcctgacctt   1359

 ttaaattcct gggggtaaat tttagaatat taaattcttc atctttaaag ggaattgtaa   1419

 tgtgctattc aaacttgttt ccttgatgag ccctgaaata ctgttgacat taactttcat   1479

 aaatgaagca taacacttac tagtttagag aaatggtaga tgaaatgctc tttacattct   1539

 aattttctgt gtgtggtgct aatttccatt gtgacttgtg gaatttaggg aagtgagtag   1599

 ctgatcaaca ccttaaaatt catttaacta cttatttaaa acagaagatg agagattcaa   1659

 aaatatcagc aaaagttggc catggtcaac tacacttttc agaattcttt tctaccaatt   1719

 tctaattaga ttctcctttt cctagctcag agttgactgt ctgctagtgg tattttctcc   1779

 ttaaactgtc atattcttac aacagtgaca ttggactcat ttccatagga ggtcactttc   1839

 catagcacac taatcatagt gacccaaaac aggattcatc aagtcaagtg agcgaatcaa   1899

 tacgccgaaa aataccttaa acggaacaac aaatccattt ccaccatcac tcatgcttac   1959

 tgtaaaacaa gaggcaggac cagttacaaa aatcctaatt cacgaaaccc accaccataa   2019

 accacagctg tccaataacg gagtacagac aacagcgctt acagaagttc tacgtaaatc   2079

 acaactggac accctaaaag gttcattggc aagaacacta cagacatttc agaaaatcac   2139

 aaacgacagg acaccgcctg tactaaacgc ctattgagaa cctcaacaga agacaagaac   2199

 aacgacatcc cagaaaaggg gagaccaaac aacaacacca acatacaacc accacacaca   2259

 aagtgacaca acgggaaacc aaacaacagc aaactaagaa caaaatggag cggtagagac   2319

 aatatacgga cagcacgaca tcacccacca gatgaagcaa gcaatacaac ccacgcgagc   2379

 aaacacgaca gaacaggcac agagacacgg cataca                             2415




      <210> 211
      <211> 849
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (38)..(331)

      <400> 211
 cacgcgtcgc gcagctccct cgcggcggct cacggag atg gct ctt gac tcg gac      55
                                          Met Ala Leu Asp Ser Asp
                                            1               5

 ttg tgg tcg cga ttg gag gaa aaa gcg cgg gcc aag tgc gaa cga gat      103
 Leu Trp Ser Arg Leu Glu Glu Lys Ala Arg Ala Lys Cys Glu Arg Asp
              10                  15                  20

 gag gct ggg aac ccg gcc aag gaa agc agc gac gct gac gga gag gcg      151
 Glu Ala Gly Asn Pro Ala Lys Glu Ser Ser Asp Ala Asp Gly Glu Ala
          25                  30                  35

 gag gaa gaa ggg gag agc gag aag ggg gcg ggg cct agg agt gct ggg      199
 Glu Glu Glu Gly Glu Ser Glu Lys Gly Ala Gly Pro Arg Ser Ala Gly
      40                  45                  50

 tgg cgc gcg ctc cgg cgg ctc tgg gac agg gtc ctg ggg cct gcg cgg      247
 Trp Arg Ala Leu Arg Arg Leu Trp Asp Arg Val Leu Gly Pro Ala Arg
  55                  60                  65                  70

 cgc tgg cgg cgt ccg ctg cct agc aac gtg ctc tac tgt gcg gag atc      295
 Arg Trp Arg Arg Pro Leu Pro Ser Asn Val Leu Tyr Cys Ala Glu Ile
                  75                  80                  85

 aag gac att ggc cac ctg acc cgt tgc acg ttg taa ccga ggaactcgga      345
 Lys Asp Ile Gly His Leu Thr Arg Cys Thr Leu 
              90                  95

 agctacagcc gaaggaaggt gggagctgca gcctcgcggg ggctgatgtc aagactactc    405

 tctctcagat cccaggattg gcatgtgatg agagagatga gccgaaggca ggagggaacg    465

 ccctgggagg tgttgatgct gagttgggga ggctcctaga cgaactcgcc cccatctact    525

 gactgtgcca gtcttacatt ttcaggatgg agtggccaag ggatgatata aacaaagcct    585

 acgttaccgt gggaagaaga cagactgttt tcttagctgg ggacgttggc ctttcgtcca    645

 ggatggctct ggtgtgtggg agcaaccagg tcccatatta ggcaattctt tgtcaatggt    705

 ctgaattttg tatgttttaa cgatggaccg ggagagacag aggctaattt acggcgtcac    765

 tgtaaatctc aattttctgg gcatgtaagg gatgatggta tggactggat gtttcacaat    825

 acccaggtcg ggggttccga acaa                                           849




      <210> 212
      <211> 1692
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (379)..(570)

      <220>
      <221> misc_feature
      <222> (1)...(1692)
      <223> n = a,t,c or g

      <400> 212
 tatttttttt tttttttttt ttctagaaga atccttttta aaagaattac atgaatccca     60

 atatatagaa gagttcaaat caaaacctac ctgaccaaag cacagattgt ggggaagggg    120

 tcttccttgg gtccctgccc actctttgcc cctaccgggt gatcttagga cacctttctg    180

 gaaccctggg gctatgcaga accgggtttt taaaaactat ggaattacta ggctagatgc    240

 tagaaataca atcatcaaga aaacctggac tctatcccct cgtacgtctc agttttacag    300

 ggaaggtaac agatgaaaag caatgactgt taatacaagt taaaaggtga taaacaatag    360

 gaaaacaaga gagagata  atg tgt gga gaa ttc aga aga gac aga gaa act     411
                      Met Cys Gly Glu Phe Arg Arg Asp Arg Glu Thr
                        1               5                  10

 tct agt cgc ggg atg aat gaa gag gag gaa aaa gag gaa gag aag aaa      459
 Ser Ser Arg Gly Met Asn Glu Glu Glu Glu Lys Glu Glu Glu Lys Lys
              15                  20                  25

 gag aaa gag gaa atg gaa atg gaa ata atg gaa atg gag gag gaa aaa      507
 Glu Lys Glu Glu Met Glu Met Glu Ile Met Glu Met Glu Glu Glu Lys
          30                  35                  40

 gaa gag aga gag gaa gag gag gag gaa aca caa aaa gaa aag atg gag      555
 Glu Glu Arg Glu Glu Glu Glu Glu Glu Thr Gln Lys Glu Lys Met Glu
      45                  50                  55

 gaa gag gaa aaa taa gagtagaaag aggaggaaaa agatgtatca ccaatataaa      610
 Glu Glu Glu Lys 
  60

 ccaaaagtgt aatacaaaaa aagacagaaa aaaaaaaaag gtaaaacact gagttttaac    670

 aagaaagaaa atatgcaaac caccattgga atgtttttta ttcccttctc tcctatactt    730

 attcaatcaa tttaaatttg taaaacaaag aaacaaaaaa catgtaaggt gggctctttg    790

 acactaagaa cagataaaga catgacagga aaaacactga aaaacatttg accagtctaa    850

 ttaatcttaa gatttcacca tgttattcta ataaagtagg gaattttcat tttctaaaca    910

 tgtttccatc tctgtgtttt aaatagtaag gtgcttaaga tcattccaag ttcataacaa    970

 ccattgaata aaatttgtat ttttttgttt ttactgttac tgtcatagtt tttattggtg   1030

 gtagtggtat tttcatgtga tattaaggta tctaatatta ttatttgtct ttgtggtttt   1090

 tggaatagtt taagtggtac ctgtacatcc tgctaggatg canacttatt atttataatt   1150

 aatgttcaat atttcattaa agacttgctg taatcttctg ccaccaaggg ctaataaatg   1210

 ccataattnt aattagttgt ggtagaggaa tctgcgtgct ttcaacatta tatgataaaa   1270

 taaataaatt ctttaaaact atttaactcg tattcaatag gtatagtaaa aggtaacaga   1330

 ctaataagat aactgcttac cactagntat actaataatt gaactaanta aaaataccta   1390

 gcataggaga tttctttatc tatanaataa atggatagca ctagatgacc actaagacct   1450

 cttcatcaat gatattcatg atcaactttg aaaggatcaa tagtattgtg aagtcactaa   1510

 gcaaacacct gagggaaaac ttgattccat gaaaatatcc tgaactaaca ccttatatgc   1570

 attgcattca tactaattgc tatgttgccc cttataaacc atggactgga ttgaaaggtg   1630

 tataattctt tattcagggc tctggacctc ttcattggaa ccaagttata taccgaggta   1690

 at                                                                  1692




      <210> 213
      <211> 1734
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (381)..(1241)

      <400> 213
 agcgggttgc ccggccctct cccgcgcagc cccgggcttc cgcaggtacc tgtgctcgcc     60

 cccgggaagg ggcctcgcag gcgaatctcc agtttcgagt gtgcccggtc cctgggttcg    120

 ctcgccggcg accccaccgc ccgccttaga tgagaaggca gcgctccagc ctcgtcctca    180

 cgccgcctcc cgtgggcgcc ctcagctgcc ttcgcggcga cgacacacgc gctccccgca    240

 gcgggctctg ggctgaggga cctggcgagg gaggcagtgg ccgcgcagtc cttccttcag    300

 aagggaaatt tctgagggtc aggaagggga atctgtacct cactccttga acaccaagga    360

 aggaatattg ggaaaccaaa    atg agg cac aat cag atg tgt tgt gag aca     410
                          Met Arg His Asn Gln Met Cys Cys Glu Thr
                            1               5                  10

 cca cct act gtc act gtt tat gta aaa tca ggg tca aat aga tca cat      458
 Pro Pro Thr Val Thr Val Tyr Val Lys Ser Gly Ser Asn Arg Ser His
                  15                  20                  25

 cag cct aaa aag ccc att act ctg aag cgt cct att tgt aaa gat aat      506
 Gln Pro Lys Lys Pro Ile Thr Leu Lys Arg Pro Ile Cys Lys Asp Asn
              30                  35                  40

 tgg caa gca ttt gaa aaa aat aca cat aat aac aac aaa tct aaa cgc      554
 Trp Gln Ala Phe Glu Lys Asn Thr His Asn Asn Asn Lys Ser Lys Arg
          45                  50                  55

 ccc aaa gga cct tgt ctg gtt ata cag cgt cag gat atg act gct ttc      602
 Pro Lys Gly Pro Cys Leu Val Ile Gln Arg Gln Asp Met Thr Ala Phe
      60                  65                  70

 ttt aaa tta ttt gat gac gat tta att caa gat ttc ttg tgg atg gac      650
 Phe Lys Leu Phe Asp Asp Asp Leu Ile Gln Asp Phe Leu Trp Met Asp
  75                  80                  85                  90

 tgc tgc tgt aaa att gca gac aag tat ctt ttg gct atg acc ttt gtt      698
 Cys Cys Cys Lys Ile Ala Asp Lys Tyr Leu Leu Ala Met Thr Phe Val
                  95                 100                 105

 tat ttc aag agg gct aaa ttt act ata agt gag cat acc agg ata aat      746
 Tyr Phe Lys Arg Ala Lys Phe Thr Ile Ser Glu His Thr Arg Ile Asn
             110                 115                 120

 ttc ttt att gct ctg tat ctg gct aat aca gtt gaa gaa gat gaa gaa      794
 Phe Phe Ile Ala Leu Tyr Leu Ala Asn Thr Val Glu Glu Asp Glu Glu
         125                 130                 135

 gaa acc aag tac gaa att ttt cca tgg gct tta ggg aaa aac tgg aga      842
 Glu Thr Lys Tyr Glu Ile Phe Pro Trp Ala Leu Gly Lys Asn Trp Arg
     140                 145                 150

 aaa ttg ttc cct aat ttc tta aag tta agg gac cag ctc tgg gat aga      890
 Lys Leu Phe Pro Asn Phe Leu Lys Leu Arg Asp Gln Leu Trp Asp Arg
 155                 160                 165                 170

 att gac tat agg gct att gta agc agg cga tgt tgt gag gag gtt atg      938
 Ile Asp Tyr Arg Ala Ile Val Ser Arg Arg Cys Cys Glu Glu Val Met
                 175                 180                 185

 gcc att gca cca acc cat tat atc tgg caa aga gaa cgt tct gtt cat      986
 Ala Ile Ala Pro Thr His Tyr Ile Trp Gln Arg Glu Arg Ser Val His
             190                 195                 200

 cac agt gga gct gtc aga aac tac aac aga gat gaa gtt cag ctg ccc     1034
 His Ser Gly Ala Val Arg Asn Tyr Asn Arg Asp Glu Val Gln Leu Pro
         205                 210                 215

 cgg gga cct agt gcc aca cca gta gat tgt tca ctc tgt ggt aaa aaa     1082
 Arg Gly Pro Ser Ala Thr Pro Val Asp Cys Ser Leu Cys Gly Lys Lys
     220                 225                 230

 aga aga tat gtt aga ctg gga ttg tct tca tca tca tct tta tcc agt     1130
 Arg Arg Tyr Val Arg Leu Gly Leu Ser Ser Ser Ser Ser Leu Ser Ser
 235                 240                 245                 250

 cat aca gca ggg gtg aca gaa aaa cat tct cag gac tca tac aac tca     1178
 His Thr Ala Gly Val Thr Glu Lys His Ser Gln Asp Ser Tyr Asn Ser
                 255                 260                 265

 ctg tca atg gac ata ata ggt gat cct tct caa gct tat act ggt tct     1226
 Leu Ser Met Asp Ile Ile Gly Asp Pro Ser Gln Ala Tyr Thr Gly Ser
             270                 275                 280

 gaa ggt atg att tag taatatgcca gaattagatt tatgcatgtt gtttactgag     1281
 Glu Gly Met Ile 
         285

 ctctagtcag tcctttctgg cggggataca taataattta tatactccaa caatatgagt   1341

 taaattaatc ttgaaacttt ctcccctttc agttactttt tgtcttgtgt ccatatttgt   1401

 tttgtggtga cccacctaaa cagattttta atgtgaccta tgttaagttg aaaactaatg   1461

 caccataagc ctcagtattt taagagcctg aatcattttt ttgaaatgtt tattttattc   1521

 aaaagggttt caagaagaaa ataaatttac ttgtaatcac cttccccagc ggtaggctca   1581

 gagcgcgcca cgcccccccc tcgccgcacc ttcgcggccc ccgtctctag cctcctctcg   1641

 cctgaacgcc cctctgcatt tacccccacc cgcacaggta tggttcggct accacacccc   1701

 tccgccccac tcgtgacccg accccccgac ctc                                1734




      <210> 214
      <211> 2225
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (810)..(2225)

      <400> 214
 cgcacaagcg cttagggcga ctgccagcac cgactcctgc ccggagttgc tggactgcag     60

 tacttctagg ctcccaggaa cacttgagca acgcggcggc acagggtggg gcaaggacct    120

 caacttccct tcccaccctc gacccaacga gaaggcaggg gccagaggcc gcggttgcag    180

 cccgggtccc cgcagctggc cgcgttcgtg acgtcagccg gccggcccct cgggtcaccg    240

 tggccgcggg acgctgtttg cgagctgcca gcgtcaacac ccgcgcgggg cgcttaaagc    300

 ttcgcgttgt ttccaggagc cttttcctct gtgtgggact gctgagaaac tatgagggca    360

 gccccactgt tcgtgaattc agagaattaa ctgaacttga acagcgggaa cttggttccc    420

 ctgggcagcc gggggcaggg ggcgccaagg ccgtggcgat aatgaaggct gagacggcca    480

 aggccagcgg gtcggcgcgg ggcactcccg ggccggagtg gccatcggcc ggagttcagg    540

 agtttggtat acaccaaagg agaaatttac agaggtcaaa gaaaggctct tttgcagtta    600

 aggagagggg agggggagga gaggaagggg agagtgaggg acacaccaca agcgtaaaac    660

 gaactggtgg cattcagtca agaaggcagg tgctctgtcc cgtggcccca gcaaaaggaa    720

 agaaaaattt gcagtctggg cgaatccaaa ggaacaaggc aacggacggc gcaacccagc    780

 cccggctgac ggacgctggc gactcagac  atg gac agt agc tgc cac aac gcg     833
                                  Met Asp Ser Ser Cys His Asn Ala
                                    1               5

 act acc aaa atg tta gcg act gct cca gct cgg ggc aac atg atg agc      881
 Thr Thr Lys Met Leu Ala Thr Ala Pro Ala Arg Gly Asn Met Met Ser
      10                  15                  20

 acg tcc aaa ccc ttg gct ttc tcc att gaa cga atc atg gcg cgc acc      929
 Thr Ser Lys Pro Leu Ala Phe Ser Ile Glu Arg Ile Met Ala Arg Thr
  25                  30                  35                  40

 cca gag ccc aag gcc ctg cca gtc ccc cac ttc ctg cag gga gcc tta      977
 Pro Glu Pro Lys Ala Leu Pro Val Pro His Phe Leu Gln Gly Ala Leu
                  45                  50                  55

 ccc aag ggg gaa ccc aag cac tct ctg cat ctc aac tcg tcg atc ccc     1025
 Pro Lys Gly Glu Pro Lys His Ser Leu His Leu Asn Ser Ser Ile Pro
              60                  65                  70

 tgc atg atc ccc ttc gtg cct gtg gcc tac gac acg agc ccc aag gca     1073
 Cys Met Ile Pro Phe Val Pro Val Ala Tyr Asp Thr Ser Pro Lys Ala
          75                  80                  85

 gga gtg acg ggc tcc gag ccg cgg aag gcc agt ctg gag gcc ccg gcg     1121
 Gly Val Thr Gly Ser Glu Pro Arg Lys Ala Ser Leu Glu Ala Pro Ala
      90                  95                 100

 gcg ccc gcg gcg gtg ccc tcg gct ccc gca ttc agc tgc agc gac ctg     1169
 Ala Pro Ala Ala Val Pro Ser Ala Pro Ala Phe Ser Cys Ser Asp Leu
 105                 110                 115                 120

 ctc aac tgc gca ctg agt ctc aag ggc gac ctg gcc cgc gac gcg ctg     1217
 Leu Asn Cys Ala Leu Ser Leu Lys Gly Asp Leu Ala Arg Asp Ala Leu
                 125                 130                 135

 ccg ctg cag cag tac aag ctg gta agg ccg cgt gtg gtc aac cac tct     1265
 Pro Leu Gln Gln Tyr Lys Leu Val Arg Pro Arg Val Val Asn His Ser
             140                 145                 150

 tca ttc cac gcc atg ggc gcc ttg tgc tac ctg aac cga ggt gac ggc     1313
 Ser Phe His Ala Met Gly Ala Leu Cys Tyr Leu Asn Arg Gly Asp Gly
         155                 160                 165

 cca tgc cac ccg gca gcc ggc gtg aac atc cac ccg gtg gcc tcc tac     1361
 Pro Cys His Pro Ala Ala Gly Val Asn Ile His Pro Val Ala Ser Tyr
     170                 175                 180

 ttc ctc agt tcc cct ttg cac ccg cag cca aaa acg tat tta gcc gaa     1409
 Phe Leu Ser Ser Pro Leu His Pro Gln Pro Lys Thr Tyr Leu Ala Glu
 185                 190                 195                 200

 agg aat aaa ctg gtg gtc ccg gcg gtg gag aaa tac cct tct gga gta     1457
 Arg Asn Lys Leu Val Val Pro Ala Val Glu Lys Tyr Pro Ser Gly Val
                 205                 210                 215

 gct ttc aaa gac ctg tcc cag gct cag ctg cag cat tac atg aaa gaa     1505
 Ala Phe Lys Asp Leu Ser Gln Ala Gln Leu Gln His Tyr Met Lys Glu
             220                 225                 230

 agc gcc cag ctt ctg tcg gaa aaa atc gcg ttc aaa acc tcg gat ttc     1553
 Ser Ala Gln Leu Leu Ser Glu Lys Ile Ala Phe Lys Thr Ser Asp Phe
         235                 240                 245

 agc cga ggc tct cct aat gcc aag ccc aaa gtt ttc act tgc gaa gtc     1601
 Ser Arg Gly Ser Pro Asn Ala Lys Pro Lys Val Phe Thr Cys Glu Val
     250                 255                 260

 ttt aat gcg cac tat aac tta acc cgt cac atg cca gtg cac aca gga     1649
 Phe Asn Ala His Tyr Asn Leu Thr Arg His Met Pro Val His Thr Gly
 265                 270                 275                 280

 gcc aga ccc ttc gtt tgc aaa gtg tgc gga aaa ggt ttc agg caa gca     1697
 Ala Arg Pro Phe Val Cys Lys Val Cys Gly Lys Gly Phe Arg Gln Ala
                 285                 290                 295

 agc acc ctg tgc agg cac aag atc att cac acg cag gaa aaa cct cac     1745
 Ser Thr Leu Cys Arg His Lys Ile Ile His Thr Gln Glu Lys Pro His
             300                 305                 310

 aaa tgt aac cag tgt ggc aaa gca ttt aat aga agt tcc act tta aac     1793
 Lys Cys Asn Gln Cys Gly Lys Ala Phe Asn Arg Ser Ser Thr Leu Asn
         315                 320                 325

 act cat acc cga ata cac gcg ggc tac aaa ccg ttt gtg tgt gaa ttc     1841
 Thr His Thr Arg Ile His Ala Gly Tyr Lys Pro Phe Val Cys Glu Phe
     330                 335                 340

 tgt ggc aaa ggg ttt cat caa aaa ggg aat tac aaa aac cac aag ttg     1889
 Cys Gly Lys Gly Phe His Gln Lys Gly Asn Tyr Lys Asn His Lys Leu
 345                 350                 355                 360

 acc cac agc ggg gag aag cag ttc aag tgc aat atc tgc aac aag gct     1937
 Thr His Ser Gly Glu Lys Gln Phe Lys Cys Asn Ile Cys Asn Lys Ala
                 365                 370                 375

 ttc cac cag gtt tac aac ctc acc ttc cac atg cac acc cac aac gac     1985
 Phe His Gln Val Tyr Asn Leu Thr Phe His Met His Thr His Asn Asp
             380                 385                 390

 aag aag cct ttc acc tgc ccc acg tgc ggc aag ggt ttc tgc agg aac     2033
 Lys Lys Pro Phe Thr Cys Pro Thr Cys Gly Lys Gly Phe Cys Arg Asn
         395                 400                 405

 ttt gac ctc aag aag cat gtc cgc aag ctg cac gac agc agc ctg ggg     2081
 Phe Asp Leu Lys Lys His Val Arg Lys Leu His Asp Ser Ser Leu Gly
     410                 415                 420

 ctg gcc cgc acg cca gct ggc gaa cca ggc act gaa ccg ccg ccc ccg     2129
 Leu Ala Arg Thr Pro Ala Gly Glu Pro Gly Thr Glu Pro Pro Pro Pro
 425                 430                 435                 440

 cta ccg cag cag ccg ccg atg acg ctg cct cct ctg cag ccg ccg ctg     2177
 Leu Pro Gln Gln Pro Pro Met Thr Leu Pro Pro Leu Gln Pro Pro Leu
                 445                 450                 455

 cca acc ccg ggg ccc ctg cag ccc ggg ctc cac cag ggc cac cag tga     2225
 Pro Thr Pro Gly Pro Leu Gln Pro Gly Leu His Gln Gly His Gln 
             460                 465                 470





      <210> 215
      <211> 2100
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1416)

      <400> 215
  atg gtg ctg gac tca ggg gct cag gcg tat gat cag gca ccc ccc agc      48
  Met Val Leu Asp Ser Gly Ala Gln Ala Tyr Asp Gln Ala Pro Pro Ser
    1               5                  10                  15

 ccg cct acc agt ccc cca tcc ctg cgc cat agg ctg aag ccc tca gac       96
 Pro Pro Thr Ser Pro Pro Ser Leu Arg His Arg Leu Lys Pro Ser Asp
              20                  25                  30

 cga gat ggg cca cca ctg tac ccc tgg tct cag tcc ctg gcc ttg ccc      144
 Arg Asp Gly Pro Pro Leu Tyr Pro Trp Ser Gln Ser Leu Ala Leu Pro
          35                  40                  45

 ctg gct ctg gca gtc ccc cca gcg ctg cag ccc cag cct gag cag cag      192
 Leu Ala Leu Ala Val Pro Pro Ala Leu Gln Pro Gln Pro Glu Gln Gln
      50                  55                  60

 ccg ttc tca cag atg ctc ctg ggc cac cgt ggc cac atg cgt cgc agt      240
 Pro Phe Ser Gln Met Leu Leu Gly His Arg Gly His Met Arg Arg Ser
  65                  70                  75                  80

 gag agc acc tac tct gta aat agt act ggc cgg cgg ggg cgt ggc acc      288
 Glu Ser Thr Tyr Ser Val Asn Ser Thr Gly Arg Arg Gly Arg Gly Thr
                  85                  90                  95

 ctg gga cgg cct cca cct gga cgg gga cgg aac cca ggt ggg ggc acc      336
 Leu Gly Arg Pro Pro Pro Gly Arg Gly Arg Asn Pro Gly Gly Gly Thr
             100                 105                 110

 ctg cgg cct gca gcc tcc ctg cct cac att gct aag act caa agg gat      384
 Leu Arg Pro Ala Ala Ser Leu Pro His Ile Ala Lys Thr Gln Arg Asp
         115                 120                 125

 gca ggc cat att gcc agc aag agc ccc tgc atg ttg gtg gcc ctg cgg      432
 Ala Gly His Ile Ala Ser Lys Ser Pro Cys Met Leu Val Ala Leu Arg
     130                 135                 140

 cca acc aac atg gac cgt gag cga gac aag ttc ttc cag tcc cat tac      480
 Pro Thr Asn Met Asp Arg Glu Arg Asp Lys Phe Phe Gln Ser His Tyr
 145                 150                 155                 160

 acc tac aat cca cag ttt gag tac cag gag ccc atg ccc acg gct gtg      528
 Thr Tyr Asn Pro Gln Phe Glu Tyr Gln Glu Pro Met Pro Thr Ala Val
                 165                 170                 175

 ctg gaa aag tac tgc gag gcc tct gga cag ttc atc cat cag gca gtt      576
 Leu Glu Lys Tyr Cys Glu Ala Ser Gly Gln Phe Ile His Gln Ala Val
             180                 185                 190

 ggc atc att gag gct gtt ctg gag aag ttt gga acc tat gaa cac ttt      624
 Gly Ile Ile Glu Ala Val Leu Glu Lys Phe Gly Thr Tyr Glu His Phe
         195                 200                 205

 gag gct gcc act ggg ggg cag ctg ctc acc aag tgc cag ata tgg tcg      672
 Glu Ala Ala Thr Gly Gly Gln Leu Leu Thr Lys Cys Gln Ile Trp Ser
     210                 215                 220

 att gtg cgc aaa tac atg cag aag gag ggc tgc gct ggg gag gtt gtg      720
 Ile Val Arg Lys Tyr Met Gln Lys Glu Gly Cys Ala Gly Glu Val Val
 225                 230                 235                 240

 gtg cag ctg agt gag gac ctg ctg tcc cag gca gtg atg atg gtg gag      768
 Val Gln Leu Ser Glu Asp Leu Leu Ser Gln Ala Val Met Met Val Glu
                 245                 250                 255

 aac agc cgg ccc aca ttg gcg atc aac ctg acc gga gcc cgc cag tac      816
 Asn Ser Arg Pro Thr Leu Ala Ile Asn Leu Thr Gly Ala Arg Gln Tyr
             260                 265                 270

 tgg ttg gag ggc atg ctg cgg cat gag ata ggc acc cac tac ctg cgg      864
 Trp Leu Glu Gly Met Leu Arg His Glu Ile Gly Thr His Tyr Leu Arg
         275                 280                 285

 ggc gtg aac aac gcg cgc cag ccg tgg cac aac gcg gag ggc cgg ctg      912
 Gly Val Asn Asn Ala Arg Gln Pro Trp His Asn Ala Glu Gly Arg Leu
     290                 295                 300

 cgg tac ggg ctg cgg ccg gcg aac ccc acg gag gag ggc ctg gcc agc      960
 Arg Tyr Gly Leu Arg Pro Ala Asn Pro Thr Glu Glu Gly Leu Ala Ser
 305                 310                 315                 320

 ctg cac agc gtg ctg ttc cgc aag cag ccg ttc ctg tgg cgc gct gca     1008
 Leu His Ser Val Leu Phe Arg Lys Gln Pro Phe Leu Trp Arg Ala Ala
                 325                 330                 335

 ctg ctc tac tac acc atc cac cgc gcc gcg cgc atg tcc ttc cgt cag     1056
 Leu Leu Tyr Tyr Thr Ile His Arg Ala Ala Arg Met Ser Phe Arg Gln
             340                 345                 350

 ctc ttc cag gac ctg gag cgc tac gtg cag gac gcc gat gtg cgc tgg     1104
 Leu Phe Gln Asp Leu Glu Arg Tyr Val Gln Asp Ala Asp Val Arg Trp
         355                 360                 365

 gag tac tgc gtg cgc gcc aag cgc ggc cag acc gac acc tcg ctg cca     1152
 Glu Tyr Cys Val Arg Ala Lys Arg Gly Gln Thr Asp Thr Ser Leu Pro
     370                 375                 380

 ggt tgt ttc agc aag gac cag gtg tac ctg gac ggc atc gtg cgc att     1200
 Gly Cys Phe Ser Lys Asp Gln Val Tyr Leu Asp Gly Ile Val Arg Ile
 385                 390                 395                 400

 ctg cga cat cgc cag acc atc gat ttc ccg ttg ctg acc tca ctg ggc     1248
 Leu Arg His Arg Gln Thr Ile Asp Phe Pro Leu Leu Thr Ser Leu Gly
                 405                 410                 415

 aag gtg tcc tat gag gat gtg gac cac ctg cgg ccc cat ggg gtg ctg     1296
 Lys Val Ser Tyr Glu Asp Val Asp His Leu Arg Pro His Gly Val Leu
             420                 425                 430

 gat aat acc cgg gtg ccc cac ttc atg cag gac ttg gca cgc tac cgg     1344
 Asp Asn Thr Arg Val Pro His Phe Met Gln Asp Leu Ala Arg Tyr Arg
         435                 440                 445

 cag cag ctg gag cac atc atg gcc acc aac cgg ctg gat gag gcg gag     1392
 Gln Gln Leu Glu His Ile Met Ala Thr Asn Arg Leu Asp Glu Ala Glu
     450                 455                 460

 ctg ggt cgc ctg cta ccc gac tga tgtccgttga gggctgcagt cagaggccct    1446
 Leu Gly Arg Leu Leu Pro Asp 
 465                 470

 ggacagaagc tccagatagg cccctagaac atgaagcagt ttgctctgtg cgtccacggc   1506

 ctaggtgttt cttgggggtg ttgggagggc aggagcattc cttgaggagg agtggcaaca   1566

 tcaaagtgtt tgtgtccctt gccagcctcc ctggggtctg gggacctgca gcagcatgtc   1626

 tggcaaactg agtcgccctc ctgcctccag ctctctgttg agcagaggga aggcatgggg   1686

 gcaggaagag agctgagcat tgatggggat gggggtggtt tgggaataga aacttgttct   1746

 tgcatgagat ggctttggtt gtcccagtac tccagtctct cccttccctt acctggcccc   1806

 ttggtgctcc ttcagcattt gtgctgtcta cctctcactg ggtcctggtg cgggtcgggc   1866

 tcccttctcc tggggtgatt gatggcctga gcctggggtc ctggtagtag agacccagct   1926

 ggcctggggt ctgctttccg acattttgcc tctctcactg gtcatgtatt tattccatat   1986

 ttatatggtc tacttcctgt ggctgggagc agcagctcct gaaggttccg tgggggtgcg   2046

 gggggttgga caggacactc cttcttggaa ggcaccaatt ttcccagccc cact         2100




      <210> 216
      <211> 2004
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (95)..(346)

      <400> 216
 cgcagctcgg atcagcagca gcccaggagg cctcccgccc gtactttccc gcgtccatcc     60

 ctctgtccca cggtcggtga gtcagcggag cctg    atg gag gcc ttg ggc tct     112
                                          Met Glu Ala Leu Gly Ser
                                            1               5

 ggg cac tat gtg gga ggc agc atc agg tcc atg gcg gcg gcg gcc ctg      160
 Gly His Tyr Val Gly Gly Ser Ile Arg Ser Met Ala Ala Ala Ala Leu
              10                  15                  20

 tct ggc ctg gcg gtg cgg ctg tcg cgc ccg cag ggg acc cgc ggc tct      208
 Ser Gly Leu Ala Val Arg Leu Ser Arg Pro Gln Gly Thr Arg Gly Ser
          25                  30                  35

 tac ggc gcc ttc tgc aag acg ctc acg cgc acg ctg ctc acc ttc ttc      256
 Tyr Gly Ala Phe Cys Lys Thr Leu Thr Arg Thr Leu Leu Thr Phe Phe
      40                  45                  50

 gac ctg gcc tgg cgg ctg cgc aag aac ttc ttt tac ttc tat att ctg      304
 Asp Leu Ala Trp Arg Leu Arg Lys Asn Phe Phe Tyr Phe Tyr Ile Leu
  55                  60                  65                  70

 gcc tcg gtg att ctc aac gtc cac ctg cag gta tat att tag agccact      353
 Ala Ser Val Ile Leu Asn Val His Leu Gln Val Tyr Ile 
                  75                  80

 aactttgtgg catttggggg ctcctcgtca ggatggctga cttccaccca cctgctcacc    413

 caccctagtc agcattccca ggccccagtg tggtctgtgg ggctgtgtgc agagtgtgcg    473

 agacgctatg tccagcaaag gctccgtggt tctggcctac agtggcggcc tggacacctc    533

 gtgcatcctc gtgtggctga aggaacaagg ctatgacgtc attgcctatc tggccaacat    593

 tggccagaag gaagacttcg aggaagccag gaagaaggca ctgaagcttg gggccaaaaa    653

 ggtgttcatt gaggatgtca gcagggagtt tgtggaggag ttcatctggc cggccatcca    713

 gtccagcgca ctgtatgagg accgctacct cctgggcacc tctcttgcca ggccctgcat    773

 cgcccgcaaa caagtggaaa tcgcccagcg ggagggggcc aagtatgtgt cccacggcgc    833

 cacaggaaag gggaacgatc aggtccggtt tgagctcagc tgctactcac tggcccccca    893

 gataaaggtc attgctccct ggaggatgcc tgaattctac aaccggttca agggccgcaa    953

 tgacctgatg gagtacgcaa agcaacacgg gattcccatc ccggtcactc ccaagaaccc   1013

 gtggagcatg gatgagaacc tcatgcacat cagctacgag gctggaatcc tggagaaccc   1073

 caagaaccaa gcgcctccag gtctctacac gaagacccag gacccagcca aagcccccaa   1133

 cacccctgac attctcgaga tcgagttcaa aaaaggggtc cctgtgaagg tgaccaacgt   1193

 caaggatggc accacccacc agacctcctt ggagctcttc atgtacctga acgaagtcgc   1253

 gggcaagcat ggcgtgggcc gtattgacat cgtggagaac cgcttcattg gaatgaagtc   1313

 ccgaggtatc tacgagaccc cagcaggcac catcctttac catgctcatt tagacatcga   1373

 ggccttcacc atggaccggg aagtgcgcaa aatcaaacaa ggcctgggct tgaaatttgc   1433

 tgagctggtg tataccggtt tctggcacag ccctgagtgt gaatttgtcc gccactgcat   1493

 cgccaagtcc caggagcgag tggaagggaa agtgcaggtg tccgtcctca agggccaggt   1553

 gtacatcctc ggccgggagt ccccactgtc tctctacaat gaggagctgg tgagcatgaa   1613

 cgtgcagggt gattatgagc caactgatgc caccgggttc atcaacatca aattcctcag   1673

 cccacatccg gtgacctatc aaattgaggc aagtttaaag ccagagcagc ctggtgtcac   1733

 gctggtgtcc atcccagtct tcctggcacc ttcctggcac aaagcctcag agctgatccc   1793

 gacccagtcc ttccgagcac aggcctgggg ctcagtgagg ttcatggccc cgctcctggg   1853

 agcagctgac cctgtgcacc ctgcttggct gggtccaccc atctgccaat gctgtgtcca   1913

 gaagccccac gtcagctctg tcctggctgt ggacatcctg gatgtaagac gtgggaggaa   1973

 ccccagccat cacctctaca agaaaactta a                                  2004




      <210> 217
      <211> 2035
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1296)..(1577)

      <400> 217
 ctggcccgca gtcttcagac atgctgccct tgtctgacct acacaggctc aggtgacgcg     60

 agtgtgcggc aagggctgta gccggagcta gcggacttgt ggccactgag gagcttctgc    120

 ctgaacgtgc cctccaggcg acagccgctt ggtgcgcagc gcctgctcgc taagcgtcag    180

 gcccttgctg cgccctacgc cgcaggctgg gaagtagcgc aggcagtagt agtacaggca    240

 gcggtaaagc tcctccttgt agcttattgg tgtcggcggc ctggtctggg cctgcggacc    300

 cgcctgctga cactgaccgg cagtctgtgg ccatgcgtct gcgcatgcgc tctcctggaa    360

 tacccagccg ctgcgcctcg agttccgatt ggttcgcgct gggctccatg cagccgggct    420

 gcgcggccgc tcagagcggg tgcctccggg gctccggtcg ggggcctggc aggagtgggc    480

 cggggatggc cgcggcaggc ggcaggtcgg ccgtggagcc ccggggaggc ggccgccacg    540

 atcgctgccc gaagtctgcg agatgtccgg cagtccgctc agggcccctt ttgcagactc    600

 ggtgcccggt gtgcatcgat gccgcctgtc ggtcttggca ccgctggcgc agccgccgcg    660

 taggaggccc ggctccagat caccgacccc cacgagcgcc ggccctgcct gcccgctatt    720

 ttggttccat ctcttctgca tatttatgct tgcctgttac attccctggc ctctgagtgt    780

 cctttggcag tttccaaagc atttgggcaa gaaggagctt gggcagcttc acaacaggtg    840

 gggacgcgca ggggaggggc cgcggccgga ccggcagagt ttcaagggct ggcgcgccgg    900

 cggactttcc acactgtctt tcgggactgg ggttaggaga cagcccttgg ccaccactgt    960

 gtccttactt tgtcgcttta cttggggctg gacctcccct ttccagctct ggcgtgtgac   1020

 cccgcaacga gcgtggtgtc gagaccacca ccagctgggg cggtgggagc gaaggtgccc   1080

 caggctcggg gaaggtggaa accttttccc cgctccccaa gtgattgttg cgcgctccgg   1140

 tgaggggaca gtggtacctc gatttcccgt gtgccagctt cgggactcag ctgtgctttt   1200

 gtgtctcttt gattagcaaa agcaaaacga attcctcccc gaacactaag cttcctggaa   1260

 acttccctag acctaaactt gagaaccgca tataa   atg ggc ctt gag ggt tct    1313
                                          Met Gly Leu Glu Gly Ser
                                            1               5

 gtc gtc agt agc ggg tta cgt gat tgc aaa cga gca agt tta aaa cgg     1361
 Val Val Ser Ser Gly Leu Arg Asp Cys Lys Arg Ala Ser Leu Lys Arg
              10                  15                  20

 agt ggg ctt tgg gct gca gag ccg cct ggc att ctg aca gct gag cag     1409
 Ser Gly Leu Trp Ala Ala Glu Pro Pro Gly Ile Leu Thr Ala Glu Gln
          25                  30                  35

 gag gca gag gtg aga gtc caa gat gga cta aaa atg tcc cag cag ctg     1457
 Glu Ala Glu Val Arg Val Gln Asp Gly Leu Lys Met Ser Gln Gln Leu
      40                  45                  50

 gga gcc caa cct cgg ccc aac ctc gtt gaa agg agg aac att cgg tgc     1505
 Gly Ala Gln Pro Arg Pro Asn Leu Val Glu Arg Arg Asn Ile Arg Cys
  55                  60                  65                  70

 agc cgt cgg aac ctt att att tat gaa agg gga cag ctc aca gga tta     1553
 Ser Arg Arg Asn Leu Ile Ile Tyr Glu Arg Gly Gln Leu Thr Gly Leu
                  75                  80                  85

 cat ttt tct aag cca atc ctg tga ccatcctcca tgaaattctc tattttggtt    1607
 His Phe Ser Lys Pro Ile Leu 
              90

 gcatgtggtc aaaactgagc ctcactgaaa caattgaaaa caaatactcc cgacaaatct   1667

 taagaatcgt tttgaaaatc aaaaggtggg gaaaatgttg tggcttctga gctttcttca   1727

 gcccatattc tattattctc tgatgtttta tggtgtaaaa tcatacccat tccattatgt   1787

 attgattgtc aagaaggaag taggctttta ttgctatttt tatgtcagtt tccatttact   1847

 gtctcaccac atttattggg ttattgcctt tgcctttgac tcaacaggag ctggaagggt   1907

 aggaatccca aattctgttg cctaaggcag ccagttgtca gaatggactt tcctcatttt   1967

 ctattatgag gcctgaggaa agacattcag ttccaaaggc tgtgcctatc cttttaaata   2027

 gaagagag                                                            2035




      <210> 218
      <211> 660
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(660)

      <400> 218
  atg gcc aac tgg gtg ttc tgt aat cgc tgc ttc cag ccg ccc cac agg      48
  Met Ala Asn Trp Val Phe Cys Asn Arg Cys Phe Gln Pro Pro His Arg
    1               5                  10                  15

 acg tcg tgc ttc agc ctc acc aac tgc ggg cac gtg tac tgc gac gcc       96
 Thr Ser Cys Phe Ser Leu Thr Asn Cys Gly His Val Tyr Cys Asp Ala
              20                  25                  30

 tgc ctc ggc aaa ggt aaa aag aat gaa tgc ttg att tgt aaa gct cct      144
 Cys Leu Gly Lys Gly Lys Lys Asn Glu Cys Leu Ile Cys Lys Ala Pro
          35                  40                  45

 tgt cgt aca gtt ttg ctt tca aag cat acc gac gca gat atc cag gca      192
 Cys Arg Thr Val Leu Leu Ser Lys His Thr Asp Ala Asp Ile Gln Ala
      50                  55                  60

 ttc ttc atg agc ata gac agt ctg tgt aag aag tac tcc agg gaa acc      240
 Phe Phe Met Ser Ile Asp Ser Leu Cys Lys Lys Tyr Ser Arg Glu Thr
  65                  70                  75                  80

 tcc cag att tta gaa ttt caa gaa aaa cac agg aag aga ttg tta gcc      288
 Ser Gln Ile Leu Glu Phe Gln Glu Lys His Arg Lys Arg Leu Leu Ala
                  85                  90                  95

 ttc tat aga gaa aag att tct agg ttg gaa gaa tcc ctt agg aag tca      336
 Phe Tyr Arg Glu Lys Ile Ser Arg Leu Glu Glu Ser Leu Arg Lys Ser
             100                 105                 110

 gtg ctg cag ata gaa caa cta caa agt atg aga tca tca caa caa aca      384
 Val Leu Gln Ile Glu Gln Leu Gln Ser Met Arg Ser Ser Gln Gln Thr
         115                 120                 125

 gct ttc agc aca ata aaa agt tca gtt tca aca aaa cca cac gga tgc      432
 Ala Phe Ser Thr Ile Lys Ser Ser Val Ser Thr Lys Pro His Gly Cys
     130                 135                 140

 ctg ctg cca cct cac tca tca gcc ccc gac aga ctg gag tcg atg gaa      480
 Leu Leu Pro Pro His Ser Ser Ala Pro Asp Arg Leu Glu Ser Met Glu
 145                 150                 155                 160

 gtt gat ctc tct cct tct ccg att aga aaa tct gag ata gca gcc ggc      528
 Val Asp Leu Ser Pro Ser Pro Ile Arg Lys Ser Glu Ile Ala Ala Gly
                 165                 170                 175

 cct gcg aga atc tcc atg att agt cca cct caa gat gga cga atg ggc      576
 Pro Ala Arg Ile Ser Met Ile Ser Pro Pro Gln Asp Gly Arg Met Gly
             180                 185                 190

 agc gtc tcc tcc ctg ggc ccc gag cat ccc ggc ctg aca acg agt cag      624
 Ser Val Ser Ser Leu Gly Pro Glu His Pro Gly Leu Thr Thr Ser Gln
         195                 200                 205

 agg agc atg gga aag cct ctc agt gtg aag ttt tga                      660
 Arg Ser Met Gly Lys Pro Leu Ser Val Lys Phe 
     210                 215





      <210> 219
      <211> 682
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (68)..(682)

      <400> 219
 agcggggggg ctggcagcct tgccgctcgc tgtgccagtg cctggtgggc cgttctggcc     60

 atccagc  atg gtg gac tac tac gag gtg ctg gac gtg ccc cgg cag gcc     109
          Met Val Asp Tyr Tyr Glu Val Leu Asp Val Pro Arg Gln Ala
            1               5                  10

 tca tcc gag gcc atc aag aag gcg tac cgc aag ctg gcg ctc aag tgg      157
 Ser Ser Glu Ala Ile Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys Trp
  15                  20                  25                  30

 cac ccc gac aaa aac cct gag aac aag gag gaa gcg gag agg aga ttc      205
 His Pro Asp Lys Asn Pro Glu Asn Lys Glu Glu Ala Glu Arg Arg Phe
                  35                  40                  45

 aag cag gtg gcc gag gcc tac gag gtg ttg tcg gac gcc aag aaa cgc      253
 Lys Gln Val Ala Glu Ala Tyr Glu Val Leu Ser Asp Ala Lys Lys Arg
              50                  55                  60

 gat atc tat gac cgc tat ggc gag gcg ggg gcg gag ggc ggc tgc aca      301
 Asp Ile Tyr Asp Arg Tyr Gly Glu Ala Gly Ala Glu Gly Gly Cys Thr
          65                  70                  75

 ggc ggc agg ccc ttc gag gac ccc ttc gag tac gtc ttc agc ttc cgc      349
 Gly Gly Arg Pro Phe Glu Asp Pro Phe Glu Tyr Val Phe Ser Phe Arg
      80                  85                  90

 gac cca gcc gac gtc ttc agg gag ttc ttc ggc ggc cag gac cca ttc      397
 Asp Pro Ala Asp Val Phe Arg Glu Phe Phe Gly Gly Gln Asp Pro Phe
  95                 100                 105                 110

 tcc ttt gac ctc ttg gga aac ccg ctg gag aat att ttg ggg ggt gaa      445
 Ser Phe Asp Leu Leu Gly Asn Pro Leu Glu Asn Ile Leu Gly Gly Glu
                 115                 120                 125

 ttt cca gct ttt ggg ggt gtt ttt tct tct ttt gat aca gga ttt cgt      493
 Phe Pro Ala Phe Gly Gly Val Phe Ser Ser Phe Asp Thr Gly Phe Arg
             130                 135                 140

 tcc ttt ggc tcc ctg gga agt ggg ggc ctt tct tcc ttc tgc atg tcc      541
 Ser Phe Gly Ser Leu Gly Ser Gly Gly Leu Ser Ser Phe Cys Met Ser
         145                 150                 155

 tac ggt agt gat ggg aca ggc agc ttc aag tcc atg tcg act tcc act      589
 Tyr Gly Ser Asp Gly Thr Gly Ser Phe Lys Ser Met Ser Thr Ser Thr
     160                 165                 170

 gaa ata gtt gat ggt aaa aaa atc acc acc aag aga atc att gag aat      637
 Glu Ile Val Asp Gly Lys Lys Ile Thr Thr Lys Arg Ile Ile Glu Asn
 175                 180                 185                 190

 ggc caa gaa agg gtg gaa gtg gag gaa gat gga gag ttg agt taa          682
 Gly Gln Glu Arg Val Glu Val Glu Glu Asp Gly Glu Leu Ser 
                 195                 200





      <210> 220
      <211> 621
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (77)..(517)

      <400> 220
 aaggatcctt aattaaatta atcccccccc ccccccgctc ttttcctccg gggctgtctg     60

 aagatagatc gccatc    atg aac gac acc gta act atc cgc act aga aag     109
                      Met Asn Asp Thr Val Thr Ile Arg Thr Arg Lys
                        1               5                  10

 ttc atg acc aac cga cta ctt cag agg aaa caa atg gtc att gat gtc      157
 Phe Met Thr Asn Arg Leu Leu Gln Arg Lys Gln Met Val Ile Asp Val
              15                  20                  25

 ctt cac ccc ggg aag gcg aca gtg cct aag aca gaa att cgg gaa aaa      205
 Leu His Pro Gly Lys Ala Thr Val Pro Lys Thr Glu Ile Arg Glu Lys
          30                  35                  40

 cta gcc aaa atg tac aag acc aca ccg gat gtc atc ttt gta ttt gga      253
 Leu Ala Lys Met Tyr Lys Thr Thr Pro Asp Val Ile Phe Val Phe Gly
      45                  50                  55

 ttc aga act cat ttt ggt ggt ggc aag aca act ggc ttt ggc atg att      301
 Phe Arg Thr His Phe Gly Gly Gly Lys Thr Thr Gly Phe Gly Met Ile
  60                  65                  70                  75

 tat gat tcc ctg gat tat gca aag aaa aat gaa ccc aaa cat aga ctt      349
 Tyr Asp Ser Leu Asp Tyr Ala Lys Lys Asn Glu Pro Lys His Arg Leu
                  80                  85                  90

 gca aga cat ggc ctg tat gag aag aaa aag acc tca aga aag caa cga      397
 Ala Arg His Gly Leu Tyr Glu Lys Lys Lys Thr Ser Arg Lys Gln Arg
              95                 100                 105

 aag gaa cgc aag aac aga atg aag aaa gtc agg ggg act gca aag gcc      445
 Lys Glu Arg Lys Asn Arg Met Lys Lys Val Arg Gly Thr Ala Lys Ala
         110                 115                 120

 aat gtt ggt gct ggc aaa aag aag tgg gct gga gat tgg atc aca gcc      493
 Asn Val Gly Ala Gly Lys Lys Lys Trp Ala Gly Asp Trp Ile Thr Ala
     125                 130                 135

 gaa gga gta aag gtg ctg caa tga tgttagctgt ggccactgtg gatttttcgc     547
 Glu Gly Val Lys Val Leu Gln 
 140                 145

 aagaacatta ataaacttaa aacttcaaaa aaaaaaaaaa aaaagtcgac gcggccgcga    607

 atttagtagt agta                                                      621




      <210> 221
      <211> 1575
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1575)

      <400> 221
  atg aaa gaa cct cgg att ttc cct aga gag cgg cca act cct tgg act      48
  Met Lys Glu Pro Arg Ile Phe Pro Arg Glu Arg Pro Thr Pro Trp Thr
    1               5                  10                  15

 cgt gct ccg ctg cca cct cga gga cgg ctc gac ggt tcc ctg gga cca       96
 Arg Ala Pro Leu Pro Pro Arg Gly Arg Leu Asp Gly Ser Leu Gly Pro
              20                  25                  30

 cag ggg ggt cct gtt ctg aac aca ggc cac cca ctg ggt gtg aac tcg      144
 Gln Gly Gly Pro Val Leu Asn Thr Gly His Pro Leu Gly Val Asn Ser
          35                  40                  45

 gat ccc ttc ctt atg gcg gcc ggt tct ctt ggt gga aat ctg acc cca      192
 Asp Pro Phe Leu Met Ala Ala Gly Ser Leu Gly Gly Asn Leu Thr Pro
      50                  55                  60

 ttt cca agg aac cca tct cct ttt cca gct tca tca ggc tca ttg gct      240
 Phe Pro Arg Asn Pro Ser Pro Phe Pro Ala Ser Ser Gly Ser Leu Ala
  65                  70                  75                  80

 tca aat cca gca cct ttc ccg gct ggt gct cgt gac cca agt atg gct      288
 Ser Asn Pro Ala Pro Phe Pro Ala Gly Ala Arg Asp Pro Ser Met Ala
                  85                  90                  95

 tct ttt cca aga ggg atg aat ccc act ggc aca ggt gca gtt tct ttc      336
 Ser Phe Pro Arg Gly Met Asn Pro Thr Gly Thr Gly Ala Val Ser Phe
             100                 105                 110

 cca agg cct ggt ggc ctc ttg ggg cca ggc cca ggc cca ggc ccc acc      384
 Pro Arg Pro Gly Gly Leu Leu Gly Pro Gly Pro Gly Pro Gly Pro Thr
         115                 120                 125

 cta aac cct agg aca ggg gct ctg cca ggc cca ggg cct ctg tct aac      432
 Leu Asn Pro Arg Thr Gly Ala Leu Pro Gly Pro Gly Pro Leu Ser Asn
     130                 135                 140

 ccc agg tta ggg ggt ctc cca gga cca ggt cct atg tcc aac cca agg      480
 Pro Arg Leu Gly Gly Leu Pro Gly Pro Gly Pro Met Ser Asn Pro Arg
 145                 150                 155                 160

 gca ggt ggt ctc ctg gga gca ggt cct gac ccc aga ggt ggt ggt ccc      528
 Ala Gly Gly Leu Leu Gly Ala Gly Pro Asp Pro Arg Gly Gly Gly Pro
                 165                 170                 175

 atg ggc cct gga tct gga cct aac ctg aga gcc ggt gtt ctg tta acc      576
 Met Gly Pro Gly Ser Gly Pro Asn Leu Arg Ala Gly Val Leu Leu Thr
             180                 185                 190

 tct ggg aat ggt cct ccc aat cct agg cca gtt ggc ctg ggc cca gga      624
 Ser Gly Asn Gly Pro Pro Asn Pro Arg Pro Val Gly Leu Gly Pro Gly
         195                 200                 205

 cca aac ccc aat ctg aga tca ggc ttt tta ggg aca aac cct gcc ccc      672
 Pro Asn Pro Asn Leu Arg Ser Gly Phe Leu Gly Thr Asn Pro Ala Pro
     210                 215                 220

 agg tca ggt gtg ttt cca ggc cca ggc ctt ggg ccc aac cca aga cca      720
 Arg Ser Gly Val Phe Pro Gly Pro Gly Leu Gly Pro Asn Pro Arg Pro
 225                 230                 235                 240

 agt ggc ctg ggc cca ggc cct aat cta gat gcc aga gca ggt ggc ctc      768
 Ser Gly Leu Gly Pro Gly Pro Asn Leu Asp Ala Arg Ala Gly Gly Leu
                 245                 250                 255

 ttg ggc aca gga tct ggt ctt aac tta aga atg gct gga cct caa ggc      816
 Leu Gly Thr Gly Ser Gly Leu Asn Leu Arg Met Ala Gly Pro Gln Gly
             260                 265                 270

 ctc gat ctt gcc ccc att cta aga gca gca ggt ctt tta gga gca aat      864
 Leu Asp Leu Ala Pro Ile Leu Arg Ala Ala Gly Leu Leu Gly Ala Asn
         275                 280                 285

 tca gct tct ttc tca cag gct tct gga aac atg ggc aca agc cca tcc      912
 Ser Ala Ser Phe Ser Gln Ala Ser Gly Asn Met Gly Thr Ser Pro Ser
     290                 295                 300

 tcc atg gca aga gta cct ggc ccc atg ggc cca aac tcg ggt cct agc      960
 Ser Met Ala Arg Val Pro Gly Pro Met Gly Pro Asn Ser Gly Pro Ser
 305                 310                 315                 320

 tct cgg gga att ggc ctt cca ggg cca aat cca tct ccc atg tca agg     1008
 Ser Arg Gly Ile Gly Leu Pro Gly Pro Asn Pro Ser Pro Met Ser Arg
                 325                 330                 335

 gct cct ggc ccc ata ggc cct aat tca gct cat ttc tca agg cca gtt     1056
 Ala Pro Gly Pro Ile Gly Pro Asn Ser Ala His Phe Ser Arg Pro Val
             340                 345                 350

 ggc ccc atg ggg gta aat gcc aat ccc ttt ccc agg gga gca ggt tca     1104
 Gly Pro Met Gly Val Asn Ala Asn Pro Phe Pro Arg Gly Ala Gly Ser
         355                 360                 365

 tct gcc ttt tct cag tct tct ggc aca ttg gca tca aac cca gct acc     1152
 Ser Ala Phe Ser Gln Ser Ser Gly Thr Leu Ala Ser Asn Pro Ala Thr
     370                 375                 380

 ttc caa agg tcc gct ggc ctc cag ggc tca aat cca acc att ttc cca     1200
 Phe Gln Arg Ser Ala Gly Leu Gln Gly Ser Asn Pro Thr Ile Phe Pro
 385                 390                 395                 400

 aga gcc tct ggg cca ctt ggc ccc aac cca gct aac ttc cca agg gcc     1248
 Arg Ala Ser Gly Pro Leu Gly Pro Asn Pro Ala Asn Phe Pro Arg Ala
                 405                 410                 415

 act ggc ctg cag ggt cca agt cca act acc ttc cca agg tct act ggc     1296
 Thr Gly Leu Gln Gly Pro Ser Pro Thr Thr Phe Pro Arg Ser Thr Gly
             420                 425                 430

 cca tta ggc cct ggt caa gtt act ttc ccc agg cca gct gcc ggg cat     1344
 Pro Leu Gly Pro Gly Gln Val Thr Phe Pro Arg Pro Ala Ala Gly His
         435                 440                 445

 ctg ggc cct tct cca gct ggc cct gtg ggt atc aac cca gct cct ttc     1392
 Leu Gly Pro Ser Pro Ala Gly Pro Val Gly Ile Asn Pro Ala Pro Phe
     450                 455                 460

 aca agg cca act ggg acc ctg ggt ctc aac cca gct tcc ttt cca agg     1440
 Thr Arg Pro Thr Gly Thr Leu Gly Leu Asn Pro Ala Ser Phe Pro Arg
 465                 470                 475                 480

 atg aat ggc cct gca ggc aag agt ttc gtc cca ttt cct aga gtg ggg     1488
 Met Asn Gly Pro Ala Gly Lys Ser Phe Val Pro Phe Pro Arg Val Gly
                 485                 490                 495

 agc ctc cct ggc aca aac cca gct gct ttc ccc aga cca ggg ggt cca     1536
 Ser Leu Pro Gly Thr Asn Pro Ala Ala Phe Pro Arg Pro Gly Gly Pro
             500                 505                 510

 atg gct gca atg tac cca aat gga atg ttg ccc cct taa                 1575
 Met Ala Ala Met Tyr Pro Asn Gly Met Leu Pro Pro 
         515                 520





      <210> 222
      <211> 680
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (143)..(388)

      <400> 222
 caaaacctcg aaagtagaga agccgacact gcagccctca gtctgtggcc acaggcccga     60

 gagcccctgg caaaccgctg gtgtaagtct aaaagctgaa gaatttggac tccgatgttg    120

 gagggcagga ggcatccagc ac atg ttg tgg gtg aca aga ggg aga gaa gac     172
                          Met Leu Trp Val Thr Arg Gly Arg Glu Asp
                            1               5                  10

 aga aag aga gga gag ctg cag ccc ttt ggg gag ccc aaa tct agg agc      220
 Arg Lys Arg Gly Glu Leu Gln Pro Phe Gly Glu Pro Lys Ser Arg Ser
                  15                  20                  25

 tct gtg agc cag ggc tgt gac acc ctt ttt ggg gct ctg tgg ttc ctg      268
 Ser Val Ser Gln Gly Cys Asp Thr Leu Phe Gly Ala Leu Trp Phe Leu
              30                  35                  40

 ttg tct cca agc ttc tgg gca cca ttg cat tcc ctg gta cct gca gtg      316
 Leu Ser Pro Ser Phe Trp Ala Pro Leu His Ser Leu Val Pro Ala Val
          45                  50                  55

 gaa gct gct tgt ggt ata cct ggt cca gat gca gca tcg cag cga gct      364
 Glu Ala Ala Cys Gly Ile Pro Gly Pro Asp Ala Ala Ser Gln Arg Ala
      60                  65                  70

 ggt gtg tct ggc tgt gca cag tga ccagaccctg tgctcacttg ctcacacacc     418
 Gly Val Ser Gly Cys Ala Gln 
  75                  80

 cttcactgct ctgtgcctgg ctcacctttg gcagaaaacc aagaaagagc cgctgctttt    478

 gttcaacatg agctgctcca aagtccaggt agatgaggta tcccagacag ctgcgcttct    538

 tccctcctct cttttcaagg atttagctct gcctggggct tacaaaaagg attggaaatt    598

 ttcagaaatg agtgaattga agcttcaaaa ggtgaactta gtcgccgatt ccctcagcaa    658

 agagtacgca gagctgacct ag                                             680




      <210> 223
      <211> 581
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(459)

      <400> 223
  atg gca gtt cgg gct ggt gat gag tct cag ttg cag gat gag ggg aag      48
  Met Ala Val Arg Ala Gly Asp Glu Ser Gln Leu Gln Asp Glu Gly Lys
    1               5                  10                  15

 cac ccc ttg ccc tgc gta tgt ggg cgc cag gca gct cag ggg tcc cgg       96
 His Pro Leu Pro Cys Val Cys Gly Arg Gln Ala Ala Gln Gly Ser Arg
              20                  25                  30

 ggg agt gga gag ctg acc ttc tgc tgt tgt ttg cag cct cct gct cgg      144
 Gly Ser Gly Glu Leu Thr Phe Cys Cys Cys Leu Gln Pro Pro Ala Arg
          35                  40                  45

 tgc gct tgg aga ggc ctt gct ggt ttt ctc aga gcg gaa gag ctc ctg      192
 Cys Ala Trp Arg Gly Leu Ala Gly Phe Leu Arg Ala Glu Glu Leu Leu
      50                  55                  60

 aac aag acg gtc aag aga aag act cac agg ctg ctg cgg gag aac agc      240
 Asn Lys Thr Val Lys Arg Lys Thr His Arg Leu Leu Arg Glu Asn Ser
  65                  70                  75                  80

 ttg tac acc tgt gta cga gcc cct ggt ctc ata gct ccc tgt tgg atg      288
 Leu Tyr Thr Cys Val Arg Ala Pro Gly Leu Ile Ala Pro Cys Trp Met
                  85                  90                  95

 tgt cag aaa gag gaa tgc aag gac agt gag gcc agg tgg gca gtg cat      336
 Cys Gln Lys Glu Glu Cys Lys Asp Ser Glu Ala Arg Trp Ala Val His
             100                 105                 110

 cac ctc acc caa gtg aat gtg gtg gtg gtg atg agg gcg agg cct ggt      384
 His Leu Thr Gln Val Asn Val Val Val Val Met Arg Ala Arg Pro Gly
         115                 120                 125

 gct tca agg agc acc ttt ctg ggg gtc tgc agg tca ctg cag gag gaa      432
 Ala Ser Arg Ser Thr Phe Leu Gly Val Cys Arg Ser Leu Gln Glu Glu
     130                 135                 140

 ccg gtc tgt tac act tct tcc att tga gaact ctctcacgtt gtgtgtggtc      484
 Pro Val Cys Tyr Thr Ser Ser Ile 
 145                 150

 tgccaaccgg aagtcgggtt catgggcggt tggtgccgat ggttaccctg gtgcatgttt    544

 ccaactgttc ggaagatggc caggagggct actaaat                             581




      <210> 224
      <211> 1397
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (282)..(695)

      <400> 224
 ccttatacac attattaaac aagaatgaca aggaatgcat taaacattaa actaatagtt     60

 tacaaaaggg aacaaaataa atctcaggaa taaataataa tgtaaggagt cagtaaagct    120

 aaaggcagaa aataatgaat ttgaaaacag tagaaatggt aaatccaaaa ctttggtggg    180

 tgtctccccc ccctcccacc gacaaggaag tgagaagaga ggcaatgaaa tagataagct    240

 actaagtgct gccaggggga agggagagaa aacacagaaa a    atg agg ggg aaa     293
                                                  Met Arg Gly Lys
                                                    1

 tac cag ata ctg aag aat tta aat tat tat aaa gga acc ttt tct gca      341
 Tyr Gln Ile Leu Lys Asn Leu Asn Tyr Tyr Lys Gly Thr Phe Ser Ala
   5                  10                  15                  20

 act ctg aaa aat gtt aga ata tcc aaa gaa att gat aat ttt cta gga      389
 Thr Leu Lys Asn Val Arg Ile Ser Lys Glu Ile Asp Asn Phe Leu Gly
                  25                  30                  35

 aaa cat gac tta cca aaa tta act cta gaa aag aat cga tac aca tca      437
 Lys His Asp Leu Pro Lys Leu Thr Leu Glu Lys Asn Arg Tyr Thr Ser
              40                  45                  50

 gta aca aca gaa gtt gag aaa gta gtt aac ata ttg cca aac ctg gaa      485
 Val Thr Thr Glu Val Glu Lys Val Val Asn Ile Leu Pro Asn Leu Glu
          55                  60                  65

 ttc atg att gaa ttc ttt gag atc tac tgt gag tac ata ctc tgc ctc      533
 Phe Met Ile Glu Phe Phe Glu Ile Tyr Cys Glu Tyr Ile Leu Cys Leu
      70                  75                  80

 tgt tca gct gtt cca gaa ctt aag aag agg aac ttc caa att ctt ttc      581
 Cys Ser Ala Val Pro Glu Leu Lys Lys Arg Asn Phe Gln Ile Leu Phe
  85                  90                  95                 100

 tca aat tca gaa aca atg cta ttg aaa tat att gga aac agg aac gaa      629
 Ser Asn Ser Glu Thr Met Leu Leu Lys Tyr Ile Gly Asn Arg Asn Glu
                 105                 110                 115

 aac tac agt tca gtt tca ctt ata ata tcc att cta aaa ttg gga att      677
 Asn Tyr Ser Ser Val Ser Leu Ile Ile Ser Ile Leu Lys Leu Gly Ile
             120                 125                 130

 aaa aat act agc ata tag gactaa atactggtac atttatcttt gtttccccaa      731
 Lys Asn Thr Ser Ile 
         135

 agattcacta aatgatggta acggaattaa aaaggagggg aaaagagtcc aggaattgag    791

 tactgaggca ttctcaggaa gagcaccaag agagggagga gatacccagc ggtcacagtg    851

 gaagtcgtct ttgagactta gagcgtttga ggaaggagtc gtctttaaaa taggttacct    911

 acctagcact tgggagacca gaccagcctg tggcaaccag tgacatcagt tcctttgagt    971

 ctttccagag atactctgta tattaagaag caaatttttt tttccttttt tacacaaatg   1031

 cattttcttg aaaattcctt ctcatgaact ttgccagcct ctctgtcttg gtttgtctga   1091

 aagggccttt gatgcactct tccatttagg tgctggggta gttgaggcaa agggacagtt   1151

 tctgtagagg gatgagggag tgacttaggg ggcctggtct tctgtccctt atctgtgtat   1211

 ctggagaagg gagcctgaac accttcattg ggatggttta aatcagtttt atgtctgtaa   1271

 cccccgtgtt ctcttttaca tactcatttt actttcgtat cggttggtaa aaatgacttt   1331

 tttttttttt tttttttaac aaaaaacaaa aattcttttt tttttttttt ttaactggta   1391

 aaaggg                                                              1397




      <210> 225
      <211> 5666
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1219)..(5253)

      <400> 225
 agcttgcgcc gccgcccgcc tgcgctcaga gactcacgca gccccagtcc cgccagtccg     60

 ccaacacagt agtgccggcc cccctctttc cctggccctg ccccccctcc ccgcctttgg    120

 ctcgctccgc ctttctgccc cccaccccca cctcacgggt acgggccatt cccggccagg    180

 aaacgccgtg gcgccgcgtt gggcctaact cgagtcctgc cgcctcccgg gagtgccgtg    240

 cgccgcagcc cgggcccagg ccccggcagc gcctgggaca aggtcttcag aactactagc    300

 agataatttg gggggacttc atattcagaa gtctatataa aggattcctc atgtccataa    360

 catgttggat gaggctctgc agctcacccc cactctcaga gtggtcagtc tccattaatt    420

 ggaccccgtg atttccaatc tctgctgtgt tggacgtcat gagcattgca atccctctgg    480

 gagtcaccac atcagataca tcctactcag atatggctgc tggatcagaa aaggaagtgg    540

 aagcccccta cctttcaaga cgaagtggca ctacaccagg atgtgaaagt ccagcgaaag    600

 agacccaagg ggcctagggg gcagcacacc cccagaagcc aagtctattc caggcagtac    660

 cagggattag ggtctgggct ggaaaaatcc tggtgttttg aatatgttca ggtccagttc    720

 agactcttga tcccacagcc acttcttgag tgagccctgt atcctgtctt tccagcagtt    780

 aatggaagag gtgcactcgt aattatgggg cagtgcagaa tggactttga tcatctcact    840

 catgctaatg tcatgccagg tttcacctga gtattaagag atccaattaa gaagaatagt    900

 tctgagtcta aaccagccca gagtggcttc tctaggggaa actccccgct cagctgccct    960

 gaatctgtgg aggctagtcc agcagttaat gagaagagcg tgtattccac tcataattat   1020

 gggaccactc agaggcatgg gtgtcgagga ctgccttatg ctacgatcat ccctcgttct   1080

 gacctgaatg gcctgccgtc gcctgtagag gaacgctgtg gagacagccc gaactctgaa   1140

 ggagaaactg tacctacctg gtgtccttgt ggtctttctc aggatggctt ccttctcaac   1200

 tgtgacaagt gcagggga  atg agc agg ggg aag gtt att aga ctt cat cgg    1251
                      Met Ser Arg Gly Lys Val Ile Arg Leu His Arg
                        1               5                  10

 cgg aag cag gac aac ata tca ggt ggg gat agc agt gca aca gaa agc     1299
 Arg Lys Gln Asp Asn Ile Ser Gly Gly Asp Ser Ser Ala Thr Glu Ser
              15                  20                  25

 tgg gat gag gag ctt tct cct tcc act gtg ttg tat aca gca aca cag     1347
 Trp Asp Glu Glu Leu Ser Pro Ser Thr Val Leu Tyr Thr Ala Thr Gln
          30                  35                  40

 cac aca cct aca agc atc acc tta act gtt aga aga acc aaa ccc aag     1395
 His Thr Pro Thr Ser Ile Thr Leu Thr Val Arg Arg Thr Lys Pro Lys
      45                  50                  55

 aag cgg aaa aag agt cca gaa aag ggt cgt gca gca cca aag acg aag     1443
 Lys Arg Lys Lys Ser Pro Glu Lys Gly Arg Ala Ala Pro Lys Thr Lys
  60                  65                  70                  75

 aaa atc aag gca ttt cga gag gga tcc cgg aag tcc ttg cgg atg aag     1491
 Lys Ile Lys Ala Phe Arg Glu Gly Ser Arg Lys Ser Leu Arg Met Lys
                  80                  85                  90

 aat tct ccc tct gaa gca cag aat tta gat gag aat aca act gag ggc     1539
 Asn Ser Pro Ser Glu Ala Gln Asn Leu Asp Glu Asn Thr Thr Glu Gly
              95                 100                 105

 tgg gaa aat cgg ata aga cta tgg act gac cag tat gaa gaa gct ttc     1587
 Trp Glu Asn Arg Ile Arg Leu Trp Thr Asp Gln Tyr Glu Glu Ala Phe
         110                 115                 120

 act aat cag tac agt gca gat gta cag aac gcg ctt gaa caa cac cta     1635
 Thr Asn Gln Tyr Ser Ala Asp Val Gln Asn Ala Leu Glu Gln His Leu
     125                 130                 135

 cat tct agc aag gaa ttt gtg ggc aaa cct act att tta gac act att     1683
 His Ser Ser Lys Glu Phe Val Gly Lys Pro Thr Ile Leu Asp Thr Ile
 140                 145                 150                 155

 aat aag act gaa ttg gcc tgt aat aac aca gtt att ggt tcc caa atg     1731
 Asn Lys Thr Glu Leu Ala Cys Asn Asn Thr Val Ile Gly Ser Gln Met
                 160                 165                 170

 cag tta cag ctg gga aga gtc act cgt gtt caa aag cac cgg aag atc     1779
 Gln Leu Gln Leu Gly Arg Val Thr Arg Val Gln Lys His Arg Lys Ile
             175                 180                 185

 ctg agg gct gca aga gat ttg gct ttg gac act ctt ata ata gag tat     1827
 Leu Arg Ala Ala Arg Asp Leu Ala Leu Asp Thr Leu Ile Ile Glu Tyr
         190                 195                 200

 cgt ggg aaa gtc atg tta cga cag caa ttt gag gtc aat ggg cat ttc     1875
 Arg Gly Lys Val Met Leu Arg Gln Gln Phe Glu Val Asn Gly His Phe
     205                 210                 215

 ttc aaa aaa cca tac ccc ttt gtg ctc ttc tac tca aaa ttc aat ggt     1923
 Phe Lys Lys Pro Tyr Pro Phe Val Leu Phe Tyr Ser Lys Phe Asn Gly
 220                 225                 230                 235

 gta gag atg tgt gtg gat gcc cgt act ttc ggt aat gat gct cgg ttc     1971
 Val Glu Met Cys Val Asp Ala Arg Thr Phe Gly Asn Asp Ala Arg Phe
                 240                 245                 250

 atc aga aga tca tgt aca cca aat gca gag gtg cga cac atg att gca     2019
 Ile Arg Arg Ser Cys Thr Pro Asn Ala Glu Val Arg His Met Ile Ala
             255                 260                 265

 gat ggg atg att cac ctg tgc atc tat gct gtg tct gcc atc acc aag     2067
 Asp Gly Met Ile His Leu Cys Ile Tyr Ala Val Ser Ala Ile Thr Lys
         270                 275                 280

 gat gct gag gtc acc ata gca ttt gat tat gag tat agt aac tgt aat     2115
 Asp Ala Glu Val Thr Ile Ala Phe Asp Tyr Glu Tyr Ser Asn Cys Asn
     285                 290                 295

 tat aaa gtg gac tgt gcc tgt cac aag gga aac cgg aat tgt cct ata     2163
 Tyr Lys Val Asp Cys Ala Cys His Lys Gly Asn Arg Asn Cys Pro Ile
 300                 305                 310                 315

 caa aaa agg aat cct aat gct aca gaa ctg cca ctc cta cca cct cct     2211
 Gln Lys Arg Asn Pro Asn Ala Thr Glu Leu Pro Leu Leu Pro Pro Pro
                 320                 325                 330

 cca agc cta ccc acc att gga gca gag act aga cgt aga aaa gca cga     2259
 Pro Ser Leu Pro Thr Ile Gly Ala Glu Thr Arg Arg Arg Lys Ala Arg
             335                 340                 345

 cgg aaa gag cta gag atg gag cag cag aat gag gct tca gag gag aat     2307
 Arg Lys Glu Leu Glu Met Glu Gln Gln Asn Glu Ala Ser Glu Glu Asn
         350                 355                 360

 aat gac cag caa tca caa gaa gtt cca gaa aaa gta act gta tcc agt     2355
 Asn Asp Gln Gln Ser Gln Glu Val Pro Glu Lys Val Thr Val Ser Ser
     365                 370                 375

 gat cat gag gaa gta gac aat cca gaa gaa aaa cca gaa gaa gag aaa     2403
 Asp His Glu Glu Val Asp Asn Pro Glu Glu Lys Pro Glu Glu Glu Lys
 380                 385                 390                 395

 gaa gag gtt ata gat gac cag gag aac cta gct cat agc agg agg acc     2451
 Glu Glu Val Ile Asp Asp Gln Glu Asn Leu Ala His Ser Arg Arg Thr
                 400                 405                 410

 agg gaa gat aga aag gta gaa gcc atc atg cat gct ttt gaa aac tta     2499
 Arg Glu Asp Arg Lys Val Glu Ala Ile Met His Ala Phe Glu Asn Leu
             415                 420                 425

 gag aaa aga aag aag cgg cgg gat cag ccc ttg gaa cag agc aac tct     2547
 Glu Lys Arg Lys Lys Arg Arg Asp Gln Pro Leu Glu Gln Ser Asn Ser
         430                 435                 440

 gat gta gag att act aca acc acc tca gag act cct gtt ggt gaa gag     2595
 Asp Val Glu Ile Thr Thr Thr Thr Ser Glu Thr Pro Val Gly Glu Glu
     445                 450                 455

 aca aaa act gaa gcc cct gaa tct gaa gtt agc aac tct gtt tca aat     2643
 Thr Lys Thr Glu Ala Pro Glu Ser Glu Val Ser Asn Ser Val Ser Asn
 460                 465                 470                 475

 gtt acc atc cca agc acc cca cag agt gtt ggt gtg aat acc cgg agg     2691
 Val Thr Ile Pro Ser Thr Pro Gln Ser Val Gly Val Asn Thr Arg Arg
                 480                 485                 490

 tct tcc caa gca ggg gat att gct gca gaa aaa cta gtc ccc aag cca     2739
 Ser Ser Gln Ala Gly Asp Ile Ala Ala Glu Lys Leu Val Pro Lys Pro
             495                 500                 505

 cct cca gca aag cct tct agg ccc cgg ccg aag agt cga att tct cgg     2787
 Pro Pro Ala Lys Pro Ser Arg Pro Arg Pro Lys Ser Arg Ile Ser Arg
         510                 515                 520

 tac agg acc agt tca gcc caa aga cta aag cgt cag aag cag gcc aat     2835
 Tyr Arg Thr Ser Ser Ala Gln Arg Leu Lys Arg Gln Lys Gln Ala Asn
     525                 530                 535

 gca cag cag gca gaa ttg tca caa gct gcc ttg gaa gag gga gga agt     2883
 Ala Gln Gln Ala Glu Leu Ser Gln Ala Ala Leu Glu Glu Gly Gly Ser
 540                 545                 550                 555

 aac agt tta gta act cct act gaa gct gga agt cta gac agt tca gga     2931
 Asn Ser Leu Val Thr Pro Thr Glu Ala Gly Ser Leu Asp Ser Ser Gly
                 560                 565                 570

 gaa aac agg cca tta aca ggg tct gac cca act gtg gtg tca att act     2979
 Glu Asn Arg Pro Leu Thr Gly Ser Asp Pro Thr Val Val Ser Ile Thr
             575                 580                 585

 gga tcc cat gtc aac cgt gct gca tct aaa tac ccc aaa acc aaa aag     3027
 Gly Ser His Val Asn Arg Ala Ala Ser Lys Tyr Pro Lys Thr Lys Lys
         590                 595                 600

 tat cta gtt aca gaa tgg ttg aat gac aaa gca gag aag caa gag tgc     3075
 Tyr Leu Val Thr Glu Trp Leu Asn Asp Lys Ala Glu Lys Gln Glu Cys
     605                 610                 615

 cct gtt gag tgc cct tta cgt atc aca acg gat cca act gta ctg gca     3123
 Pro Val Glu Cys Pro Leu Arg Ile Thr Thr Asp Pro Thr Val Leu Ala
 620                 625                 630                 635

 acg acc cta aac atg tta cca ggt ctt atc cat tcc ccg tta att tgc     3171
 Thr Thr Leu Asn Met Leu Pro Gly Leu Ile His Ser Pro Leu Ile Cys
                 640                 645                 650

 acc acc ccc aaa cac tac att cgc ttt ggc tca ccc ttt atc cct gag     3219
 Thr Thr Pro Lys His Tyr Ile Arg Phe Gly Ser Pro Phe Ile Pro Glu
             655                 660                 665

 aga cgt cga agg ccc ctt ctg cct gat ggc aca ttc agc ccc tgt aag     3267
 Arg Arg Arg Arg Pro Leu Leu Pro Asp Gly Thr Phe Ser Pro Cys Lys
         670                 675                 680

 aag cgc tgg ata aaa caa gcc tta gaa gaa ggg atg act caa aca tca     3315
 Lys Arg Trp Ile Lys Gln Ala Leu Glu Glu Gly Met Thr Gln Thr Ser
     685                 690                 695

 tct gta ccc caa gag act aga act cag cac cta tac caa agc aat gag     3363
 Ser Val Pro Gln Glu Thr Arg Thr Gln His Leu Tyr Gln Ser Asn Glu
 700                 705                 710                 715

 aat agt agc tct tct agt atc tgc aaa gac aat gca gac ttg ttg agc     3411
 Asn Ser Ser Ser Ser Ser Ile Cys Lys Asp Asn Ala Asp Leu Leu Ser
                 720                 725                 730

 cca tta aag aaa tgg aag tct cgc tat ctg atg gag cag aat gtc acc     3459
 Pro Leu Lys Lys Trp Lys Ser Arg Tyr Leu Met Glu Gln Asn Val Thr
             735                 740                 745

 aag tta ctt cgg cct ctg tct cca gtc aca cca ccc cct ccc aat tca     3507
 Lys Leu Leu Arg Pro Leu Ser Pro Val Thr Pro Pro Pro Pro Asn Ser
         750                 755                 760

 ggc tca aag agt ccc cag ctg gcc aca cct ggc tca tct cac cca gga     3555
 Gly Ser Lys Ser Pro Gln Leu Ala Thr Pro Gly Ser Ser His Pro Gly
     765                 770                 775

 gaa gag gag tgt cga aat gga tac agc ctc atg ttt tca cca gtc aca     3603
 Glu Glu Glu Cys Arg Asn Gly Tyr Ser Leu Met Phe Ser Pro Val Thr
 780                 785                 790                 795

 tct ctt act act gct agt cgc tgc aac act cct cta cag ttt gag ctt     3651
 Ser Leu Thr Thr Ala Ser Arg Cys Asn Thr Pro Leu Gln Phe Glu Leu
                 800                 805                 810

 tgt cac cga aaa gac ctg gat ttg gca aaa gta gga tac ctt gac tcc     3699
 Cys His Arg Lys Asp Leu Asp Leu Ala Lys Val Gly Tyr Leu Asp Ser
             815                 820                 825

 aac act aac agc tgt gct gat aga cct tcc cta ctc aac tca ggt cat     3747
 Asn Thr Asn Ser Cys Ala Asp Arg Pro Ser Leu Leu Asn Ser Gly His
         830                 835                 840

 tct gac ctg gct cct cat ccc tcc ctc gga ccc act tct gag act ggt     3795
 Ser Asp Leu Ala Pro His Pro Ser Leu Gly Pro Thr Ser Glu Thr Gly
     845                 850                 855

 ttc cca agc aga agt gga gat gga cat cag acc ctc gtg aga aac tca     3843
 Phe Pro Ser Arg Ser Gly Asp Gly His Gln Thr Leu Val Arg Asn Ser
 860                 865                 870                 875

 gac cag gca ttt cgg aca gag ttc aac ttg atg tat gcc tac tcc cct     3891
 Asp Gln Ala Phe Arg Thr Glu Phe Asn Leu Met Tyr Ala Tyr Ser Pro
                 880                 885                 890

 ttg aat gct atg cct cga gca gat gga ctg tat cga gga tct cct cta     3939
 Leu Asn Ala Met Pro Arg Ala Asp Gly Leu Tyr Arg Gly Ser Pro Leu
             895                 900                 905

 gtg ggg gat agg aag cct tta cat ttg gat ggg gga tat tgt tcc cct     3987
 Val Gly Asp Arg Lys Pro Leu His Leu Asp Gly Gly Tyr Cys Ser Pro
         910                 915                 920

 gca gaa gga ttt tcc agc aga tat gaa cat ggc tta atg aaa gac ctc     4035
 Ala Glu Gly Phe Ser Ser Arg Tyr Glu His Gly Leu Met Lys Asp Leu
     925                 930                 935

 tct cgt gga tcc ttg tca cct ggt ggt gaa agg gcc tgt gaa gga gtc     4083
 Ser Arg Gly Ser Leu Ser Pro Gly Gly Glu Arg Ala Cys Glu Gly Val
 940                 945                 950                 955

 cca tct gcc ccc cag aac cca cca cag agg aaa aaa gta tcc ctg ctg     4131
 Pro Ser Ala Pro Gln Asn Pro Pro Gln Arg Lys Lys Val Ser Leu Leu
                 960                 965                 970

 gag tac cga aaa cgg aaa caa gaa gct aag gaa aat tct gct ggt ggg     4179
 Glu Tyr Arg Lys Arg Lys Gln Glu Ala Lys Glu Asn Ser Ala Gly Gly
             975                 980                 985

 gga ggt gac tct gca cag agc aaa agc aag tct gca gga gct ggg caa     4227
 Gly Gly Asp Ser Ala Gln Ser Lys Ser Lys Ser Ala Gly Ala Gly Gln
         990                 995                1000

 ggc agc agt aac tcc gtt tcc gac act ggt gcc cat ggt gtg cag gga     4275
 Gly Ser Ser Asn Ser Val Ser Asp Thr Gly Ala His Gly Val Gln Gly
    1005                1010                1015

 tcc tca gcc cga act cca tct tcc cct cac aaa aaa ttc tcc cca tct     4323
 Ser Ser Ala Arg Thr Pro Ser Ser Pro His Lys Lys Phe Ser Pro Ser
1020                1025                1030                1035

 cat tcc tct atg tcc cat ttg gag gcg gta agc cca tca gat tcc aga     4371
 His Ser Ser Met Ser His Leu Glu Ala Val Ser Pro Ser Asp Ser Arg
                1040                1045                1050

 ggc act tct tca tct cac tgc aga cct caa gag aat atc agc agt agg     4419
 Gly Thr Ser Ser Ser His Cys Arg Pro Gln Glu Asn Ile Ser Ser Arg
            1055                1060                1065

 tgg atg gtt ccc aca tca gta gaa cga ctc cga gaa gga ggg agc atc     4467
 Trp Met Val Pro Thr Ser Val Glu Arg Leu Arg Glu Gly Gly Ser Ile
        1070                1075                1080

 ccc aag gtc ctc cga agc agc gtg agg gtg gcc caa aag gga gag ccc     4515
 Pro Lys Val Leu Arg Ser Ser Val Arg Val Ala Gln Lys Gly Glu Pro
    1085                1090                1095

 tct ccc aca tgg gag agt aac atc aca gag aaa gac tca gac cct gca     4563
 Ser Pro Thr Trp Glu Ser Asn Ile Thr Glu Lys Asp Ser Asp Pro Ala
1100                1105                1110                1115

 gat gga gaa ggc cca gag aca tta agc tca gca ctc tct aaa gga gca     4611
 Asp Gly Glu Gly Pro Glu Thr Leu Ser Ser Ala Leu Ser Lys Gly Ala
                1120                1125                1130

 aca gtt tac agc cct tcc aga tac agc tac cag ctc ctg cag tgt gat     4659
 Thr Val Tyr Ser Pro Ser Arg Tyr Ser Tyr Gln Leu Leu Gln Cys Asp
            1135                1140                1145

 agt cct cgg aca gaa tca caa agc ctc ctt cag cag agt tcc tcc ccc     4707
 Ser Pro Arg Thr Glu Ser Gln Ser Leu Leu Gln Gln Ser Ser Ser Pro
        1150                1155                1160

 ttc aga gga cat cct aca cag tct cca gga tac agt tat cga act act     4755
 Phe Arg Gly His Pro Thr Gln Ser Pro Gly Tyr Ser Tyr Arg Thr Thr
    1165                1170                1175

 gca ctg aga cct gga aac ccc ccc tct cac ggt tct tca gaa tca tcc     4803
 Ala Leu Arg Pro Gly Asn Pro Pro Ser His Gly Ser Ser Glu Ser Ser
1180                1185                1190                1195

 ctc tct tcc acg tcc tat tcc agc ccc gcc cac cct gtg tcc aca gac     4851
 Leu Ser Ser Thr Ser Tyr Ser Ser Pro Ala His Pro Val Ser Thr Asp
                1200                1205                1210

 tcg ttg gcc cca ttt acg ggg aca cca ggg tat ttt agc agc cag cca     4899
 Ser Leu Ala Pro Phe Thr Gly Thr Pro Gly Tyr Phe Ser Ser Gln Pro
            1215                1220                1225

 cat tct gga aac agc act ggc agc aat ctt cca agg agg agc tgc cct     4947
 His Ser Gly Asn Ser Thr Gly Ser Asn Leu Pro Arg Arg Ser Cys Pro
        1230                1235                1240

 tct agt gct gct agc cct acc ctg cag gga ccc tca gac tcg cca acc     4995
 Ser Ser Ala Ala Ser Pro Thr Leu Gln Gly Pro Ser Asp Ser Pro Thr
    1245                1250                1255

 tca gat tca gtt tct cag tcc agc aca gga act ctg agt tcc acc tcc     5043
 Ser Asp Ser Val Ser Gln Ser Ser Thr Gly Thr Leu Ser Ser Thr Ser
1260                1265                1270                1275

 ttt cct cag aac tct agg tcg tca ttg cca tca gac tta cgg act atc     5091
 Phe Pro Gln Asn Ser Arg Ser Ser Leu Pro Ser Asp Leu Arg Thr Ile
                1280                1285                1290

 agt ctg ccc agt gct ggg cag tca gct gtc tac cag gcc tcc agg gta     5139
 Ser Leu Pro Ser Ala Gly Gln Ser Ala Val Tyr Gln Ala Ser Arg Val
            1295                1300                1305

 tct gcg gtt tcc aat tca cag cac tac cca cac cgt ggg agt ggg ggt     5187
 Ser Ala Val Ser Asn Ser Gln His Tyr Pro His Arg Gly Ser Gly Gly
        1310                1315                1320

 gtg cac cag tac cga ctc cag cca ctg caa ggg tca gga gtc aag act     5235
 Val His Gln Tyr Arg Leu Gln Pro Leu Gln Gly Ser Gly Val Lys Thr
    1325                1330                1335

 cag acg gga ctt tcc tag ggcttc tggatttggg caaacagaac tgaatgagcc     5289
 Gln Thr Gly Leu Ser 
1340

 catagctgct tccttccagc tgcctctgga acctaggccg agcatattgc tgaggaacgg   5349

 ggggtacaag gtgccagagg attgggtctg gtggacaaga aacaagactt gtggtcacaa   5409

 ttggcctctg gccttggaga aagctgtaaa tcttgtctga agcagagact ataaagaagt   5469

 ttctccctgc tgtcaagggt acattgttga caagcaaatg gtgtttcggt tagtaacggt   5529

 tctaagtgca atgagttgtg ttgaagcctc cgtctcccat ccttgcctgt agcccgtagt   5589

 cacttgtgca gtgaggacat ctttttaaat ttaaaaaaaa aaaaaaaagt cgacgcggcc   5649

 gcgaatttag tagtagt                                                  5666




      <210> 226
      <211> 486
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(486)

      <400> 226
  atg gag tac aca ggg agc aaa tat atc ggg gaa tat gta gat ggg agg      48
  Met Glu Tyr Thr Gly Ser Lys Tyr Ile Gly Glu Tyr Val Asp Gly Arg
    1               5                  10                  15

 atg gag ggc aaa gcc aag tac atc ctc cct acc gaa aca ata tat gtt       96
 Met Glu Gly Lys Ala Lys Tyr Ile Leu Pro Thr Glu Thr Ile Tyr Val
              20                  25                  30

 ggg gaa atg aag gat ggc atg ttt cac ggc gag gga acc ctg tac ttc      144
 Gly Glu Met Lys Asp Gly Met Phe His Gly Glu Gly Thr Leu Tyr Phe
          35                  40                  45

 ccc agc gga agc caa tac gac gcc att tgg gaa aac gga ttg gcc ata      192
 Pro Ser Gly Ser Gln Tyr Asp Ala Ile Trp Glu Asn Gly Leu Ala Ile
      50                  55                  60

 aag ggc aca tat acg ttc tca gat ggg ctg cac tat gat gag aaa aac      240
 Lys Gly Thr Tyr Thr Phe Ser Asp Gly Leu His Tyr Asp Glu Lys Asn
  65                  70                  75                  80

 tgg cat tac tgc gac ggc tat gat cgg agg ttt tac aca gag atc ctc      288
 Trp His Tyr Cys Asp Gly Tyr Asp Arg Arg Phe Tyr Thr Glu Ile Leu
                  85                  90                  95

 aat ggc ttg aag cct gca ggt atg gct caa ctc acc aat atg gac cca      336
 Asn Gly Leu Lys Pro Ala Gly Met Ala Gln Leu Thr Asn Met Asp Pro
             100                 105                 110

 cct aga aaa atc ccc aag ggc tat tac gat tgt gga gac ggc ttc tat      384
 Pro Arg Lys Ile Pro Lys Gly Tyr Tyr Asp Cys Gly Asp Gly Phe Tyr
         115                 120                 125

 aac cca gtc acg agg gta gtc aag gac tat agg aac cgc ttt cta aga      432
 Asn Pro Val Thr Arg Val Val Lys Asp Tyr Arg Asn Arg Phe Leu Arg
     130                 135                 140

 aac gca gat gat gac gag cat gag tgg atc acc cgt acc tgt cga aag      480
 Asn Ala Asp Asp Asp Glu His Glu Trp Ile Thr Arg Thr Cys Arg Lys
 145                 150                 155                 160

 ggc tag                                                              486
 Gly 






      <210> 227
      <211> 2185
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (30)..(602)

      <400> 227
 cccacgcgtc cgttcttttc tgccgggta  atg gct gct tcc aag acc cag ggg      53
                                  Met Ala Ala Ser Lys Thr Gln Gly
                                    1               5

 gct gtc gcc cga atg cag gaa gac cgt gat ggg agc tgc agc aca gtc      101
 Ala Val Ala Arg Met Gln Glu Asp Arg Asp Gly Ser Cys Ser Thr Val
      10                  15                  20

 ggg ggt gta ggt tat ggg gac agt aag gat tgt atc ctg gag ccg ctt      149
 Gly Gly Val Gly Tyr Gly Asp Ser Lys Asp Cys Ile Leu Glu Pro Leu
  25                  30                  35                  40

 tcc ctg cca gaa agt cca ggt ggc acc acc act tta gaa ggt tct cca      197
 Ser Leu Pro Glu Ser Pro Gly Gly Thr Thr Thr Leu Glu Gly Ser Pro
                  45                  50                  55

 tct gtg cct tgt att ttc tgt gaa gaa cat ttt cct gtg gct gaa caa      245
 Ser Val Pro Cys Ile Phe Cys Glu Glu His Phe Pro Val Ala Glu Gln
              60                  65                  70

 gac aaa ctt ctg aag cac atg att att gag cat aag att gtc ata gct      293
 Asp Lys Leu Leu Lys His Met Ile Ile Glu His Lys Ile Val Ile Ala
          75                  80                  85

 gat gtc aag ttg gtt gct gat ttc caa agg tac att tta tat tgg agg      341
 Asp Val Lys Leu Val Ala Asp Phe Gln Arg Tyr Ile Leu Tyr Trp Arg
      90                  95                 100

 aaa agg ttc act gaa cag ccc atc aca gat ttt tgt agt gta ata aga      389
 Lys Arg Phe Thr Glu Gln Pro Ile Thr Asp Phe Cys Ser Val Ile Arg
 105                 110                 115                 120

 att aat tcc act gct cca ttt gaa gaa caa gag aat tat ttt ttg tta      437
 Ile Asn Ser Thr Ala Pro Phe Glu Glu Gln Glu Asn Tyr Phe Leu Leu
                 125                 130                 135

 tgt gac gtt tta cca gaa gat aga att ctt aga gaa gag ctt cag aaa      485
 Cys Asp Val Leu Pro Glu Asp Arg Ile Leu Arg Glu Glu Leu Gln Lys
             140                 145                 150

 cag aga ctg agc aga aat tct ggg aac aac agc agc aag aac gaa atg      533
 Gln Arg Leu Ser Arg Asn Ser Gly Asn Asn Ser Ser Lys Asn Glu Met
         155                 160                 165

 ata cca att ttc atg gcg ttt gta tgt ttt gca atg aag aat tcc ttg      581
 Ile Pro Ile Phe Met Ala Phe Val Cys Phe Ala Met Lys Asn Ser Leu
     170                 175                 180

 gaa aca gat ctg tta ttt tga ac cacatggcca gagaacatgc tttcaacatt      634
 Glu Thr Asp Leu Leu Phe 
 185                 190

 ggattgccag acaacattgt aaactgcaat gaatttttgt gtacattaca gaaaaagctt    694

 gacaatttgc agtgcttgta ctgtgagaag accttcaggg acaaaaatac acttaaagat    754

 cacatgagga aaaaacagca tcgtaagatt aatcctaaga acagagaata tgacagattt    814

 tatgtcatca attatttgga acttggaaaa tcgtgggaag aagttcagtt ggaagatgat    874

 cgggagttgc tggaccatca ggaagatgac tggtctgatt gggaagaaca ccctgcctct    934

 gcagtctgct tattttgtga aaagcaagca gaaacaattg agaagttgta tgtccacatg    994

 gaggatgcac acgaatttga tcttctcaaa ataaagtcag aacttggatt aaatttctat   1054

 cagcaagtga aactggtcaa ttttattcgg aggcaagttc accaatgcag atgttatggc   1114

 tgccatgtga agttcaaatc caaagcagac ttaagaactc acatggaaga aactaaacac   1174

 acttcgctgc tccccgatag aaagacgtgg gatcaactgg agtattattt tccaacctat   1234

 gaaaatgaca ctctcctgtg tacactatct gacagtgaaa gtgacctgac agctcaggaa   1294

 caaaatgaaa atgttcccat catcagtgaa gatacatcta aactgtatgc tttgaaacaa   1354

 agcagtattt tgaaccagtt gctactataa gagtacttga aaacctagaa gaaactacca   1414

 cagaagcaat ttttcatgtt tttctcctat gagacagata tgaaagaaca atttaaattt   1474

 gaacatcaac aaaagattgg tccttggtga aataaacttt tcaaaaatga atgttctttt   1534

 caaaaaataa agtagaaaaa tgcacttact aagaacatga aaaaaaatga agtaggaaaa   1594

 taagatgaag acttgtattt ggctgtaaag ttttattgtg tgatcatctt aaattatctc   1654

 accttcatta aactcataat tatatataga agtatatgtc aattacaaag aaatgaaatg   1714

 ttcaaattat ttataaacct gatttttcaa tcagtagttt cagtctcctc cccaaggacc   1774

 ttcttcatcc aacaagtgca aaatttgaat atcccttctg tactatattg ggtgagctgt   1834

 aaatgtaatg actaaaagaa aagccacaga agaaagaaga aatggtcaca gacgtggata   1894

 tatgcaatgg gccaattata ttagaacaat taagagctga ctgggtatta ccactttctg   1954

 gctgagggtg gcaaatccta gaattggact caaggcgtca actcattttc ctgcattggt   2014

 tgcactacat taaatgcact tttaaaattc acaatacttt aaactaaaaa ataattataa   2074

 tcatgggagg tccacggtca gggtaaacat ggaagaaaat agcgaaaagg ggaactgagt   2134

 aactgttgag accaggaaat aaaaggatga gagctggtta agacagtatc t            2185




      <210> 228
      <211> 2431
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (650)..(931)

      <400> 228
 atgagcgggg tgctttcacg tgcattattg tatttggctg ttgtcatcat ccttgagtct     60

 ggtgcccctg ctctgtcacc aggagagacc cacactccag ccacagggaa agcaaagctg    120

 gaacaaccca ccctggctgc caagggccag aagactgtgc ttcacactcc aggggtctca    180

 gattcagcta gagcccaaga gataacacct gtccagcgtt tagcagcagc gctgggaacg    240

 aacgcaggca ccaatccagc ttgggggcca tgtggggtag cagcggatcg ggacttcctt    300

 ctaagagaag cgatcttgag ccgtgtcacg ggattacggg acagctacca cagtagaaga    360

 gatcaaattg cccttaaaaa tctccagtct gatgtcacag aggcgaaatc tgacttcacc    420

 aaggagaccc tggcatcaca aaacacaaaa atgatttcat ccatagtcat ctcccagatg    480

 attgatgaga ataagtcaag agaaaacagg gcctccttgc ccctaccgtg tgccattgct    540

 cagtctcgtg cacatcacgc caagcaatct ctggctaacc gcagcggagt caacattcac    600

 agagcatttg cgttacttcc gggcagatta ggaatcccgg caccgtcag    atg agc     655
                                                          Met Ser
                                                            1

 gag gac ctg agg cag agc tgc cgc cca aag agg aga gac cct gtg ggg      703
 Glu Asp Leu Arg Gln Ser Cys Arg Pro Lys Arg Arg Asp Pro Val Gly
           5                  10                  15

 gcc ccc gca gag ggt ttg cat cca tca cca tca cgg cca gac gcg tgg      751
 Ala Pro Ala Glu Gly Leu His Pro Ser Pro Ser Arg Pro Asp Ala Trp
      20                  25                  30

 gcc ccc cag ccc gcg ccc tgg tgt ggg gga ctg ctg ggg act ctc tgt      799
 Ala Pro Gln Pro Ala Pro Trp Cys Gly Gly Leu Leu Gly Thr Leu Cys
  35                  40                  45                  50

 gcc cca agt gca ggg ctg agg aca cac tgt tcc agg cgc ccc cgg ctc      847
 Ala Pro Ser Ala Gly Leu Arg Thr His Cys Ser Arg Arg Pro Arg Leu
                  55                  60                  65

 tgg cca atg gcg ccc atc cag gtc ggc atc aga gat ctt ttg cct gca      895
 Trp Pro Met Ala Pro Ile Gln Val Gly Ile Arg Asp Leu Leu Pro Ala
              70                  75                  80

 cag agt tct cca gaa aca gct ccg tgg tgc ggc tga aggt tcccgaggcc      945
 Gln Ser Ser Pro Glu Thr Ala Pro Trp Cys Gly 
          85                  90

 cacactgggt tgtgtgagag acgcaagtac tgggtcaccc atgcagacga caaagagacc   1005

 agtttttctc cagacacccc actgtcagga aagagcccgc tggtgttcag ttcctgtgtc   1065

 cacctcaggg tgtctcagca gtgtccagat tcaatctatt acgtagacaa gtctctctcc   1125

 gtccccattg agccacctca aattgccagc cccaaaatgc acagatccgt cctgtcgctc   1185

 aacctcaatt gtagttccca cagattaaca gcagatggag tagatggcct agtgaacaga   1245

 gagccaataa gcgaagccct gaagcaggag ctcctggagg gagaccagga cctcgtaggc   1305

 cagcgctgga acccaggttt acaagaaagt cacttgaagg aaaccccatc gttgaggcgg   1365

 gtgcatttgg ggaccggcgc ttgtccttgg agtggttctt ttccattgga aaacacagaa   1425

 ttggcaaatg tgggagctaa ccaagtcact gtaagaaaag gggaaaagga ccatacaact   1485

 cattgtcacg ccagcgatca tgccaaccaa ctgtccattc acattcctgg ctggagttac   1545

 agggcaggtg gactctgtaa agaaaagagg ctccgtggga ttctggaccc ctcagttgca   1605

 aagtccaaag ccacagagcc ctggggtgtg ctgtggggca cttgcctcgg atgcctacaa   1665

 atgcacacct tcacctacac gtgcacccct ggctgtgtgc tccctcactc agaaataatt   1725

 tccagtggac tctatttctt ctcagatgct attgaagagg agactagtga atacgctgtc   1785

 cacatctatt tgcgttcgcg ttctatggtg ggcccatgtt gcaactccct cagtcagttc   1845

 acaggctttg gtggcattgg tctgagatgt cctcggtgga gtttagcatc actagtgaat   1905

 aaagatgtgg atgactggaa ggcagaagtc cttgccaggt ctccaaatga gcactgtgcc   1965

 tactcacact tagatggttt tctggagccg cctctaccct gcagagcttc caccactaga   2025

 cgcaaagcct ttctgctgct ggctggtgga cattcacacc acaactaccc agttcttcct   2085

 aatgaattgg gtgcatggtt gagaatcaga ggtcattgtt atacttgcac actgcacatt   2145

 cctggacggc aggattcaac tgagtcattg gcattgacct catcttaccc agtagggagc   2205

 cagggagcaa tggctcacag agtgggtgcc ctcgacctgt gggctgggtg gaggacaggt   2265

 tacgttgatg acccaacaaa gcccatgctt atgtcacgat cccttaagtg cttgatgtgt   2325

 ttccttcctc aaactacctt tccccatccc catattcaaa acctctctgg caaggaaagg   2385

 gtgaggagcg atgaaagact caccgccaag agtgccatag acatga                  2431




      <210> 229
      <211> 1761
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1761)

      <400> 229
  atg ggc ggc tgc ttc tcc aaa ccc aaa cca gtg gag ctc aag atc gag      48
  Met Gly Gly Cys Phe Ser Lys Pro Lys Pro Val Glu Leu Lys Ile Glu
    1               5                  10                  15

 gtg gtg ctg cct gag aag gag cga ggc aag gag gag ctg tcg gcc agt       96
 Val Val Leu Pro Glu Lys Glu Arg Gly Lys Glu Glu Leu Ser Ala Ser
              20                  25                  30

 ggg aag ggc agc ccc cgg gcc tac cag ggc aat ggc acg gcc cgc cac      144
 Gly Lys Gly Ser Pro Arg Ala Tyr Gln Gly Asn Gly Thr Ala Arg His
          35                  40                  45

 ttc cac acg gag gag cgc ctg tcc acc cct cac ccc tac ccc agc cct      192
 Phe His Thr Glu Glu Arg Leu Ser Thr Pro His Pro Tyr Pro Ser Pro
      50                  55                  60

 cag gat tgc gtg gag gct gct gtc tgc cac gtc aag gac ctc gag aat      240
 Gln Asp Cys Val Glu Ala Ala Val Cys His Val Lys Asp Leu Glu Asn
  65                  70                  75                  80

 ggc cag atg cgg gaa gtg gag ctg ggc tgg ggg aag gtg ttg ctg gtg      288
 Gly Gln Met Arg Glu Val Glu Leu Gly Trp Gly Lys Val Leu Leu Val
                  85                  90                  95

 aag gac aat ggg gag ttc cac gcc ctg ggc cat aag tgt ccg cac tac      336
 Lys Asp Asn Gly Glu Phe His Ala Leu Gly His Lys Cys Pro His Tyr
             100                 105                 110

 ggc gca ccc ctg gtg aaa ggc gtt ctg tcc cgt ggt cgg gtg cgc tgc      384
 Gly Ala Pro Leu Val Lys Gly Val Leu Ser Arg Gly Arg Val Arg Cys
         115                 120                 125

 ccc tgg cac ggc gcc tgc ttc aac atc agc act ggg gac ctg gag gac      432
 Pro Trp His Gly Ala Cys Phe Asn Ile Ser Thr Gly Asp Leu Glu Asp
     130                 135                 140

 ttc cct ggc ctg gac agt cta cac aag ttc cag gtg aag att gag aag      480
 Phe Pro Gly Leu Asp Ser Leu His Lys Phe Gln Val Lys Ile Glu Lys
 145                 150                 155                 160

 gag aag gtg tac gtc cgg gcc agc aag cag gcc cta cag ctg cag cga      528
 Glu Lys Val Tyr Val Arg Ala Ser Lys Gln Ala Leu Gln Leu Gln Arg
                 165                 170                 175

 agg acc aag gtg atg gcc aag tgt atc tct cca agt gct ggg tac agc      576
 Arg Thr Lys Val Met Ala Lys Cys Ile Ser Pro Ser Ala Gly Tyr Ser
             180                 185                 190

 agt agc acc aat gtg ctc att gtg ggt gca ggt gca gct ggt ctg gtg      624
 Ser Ser Thr Asn Val Leu Ile Val Gly Ala Gly Ala Ala Gly Leu Val
         195                 200                 205

 tgt gca gag aca ctg cgg cag gag ggc ttc tcc gac cgg atc gtc ctg      672
 Cys Ala Glu Thr Leu Arg Gln Glu Gly Phe Ser Asp Arg Ile Val Leu
     210                 215                 220

 tgc acg cta gac cgg cac ctt ccc tac gac cgt ccc aag ctc agc aag      720
 Cys Thr Leu Asp Arg His Leu Pro Tyr Asp Arg Pro Lys Leu Ser Lys
 225                 230                 235                 240

 tcc ctg gac aca cag cct gag cag ctg gcc ctg agg ccc aag gag ttt      768
 Ser Leu Asp Thr Gln Pro Glu Gln Leu Ala Leu Arg Pro Lys Glu Phe
                 245                 250                 255

 ttc cga gcc tat ggc atc gag gtg ctc acc gag gct cag gtg gtc aca      816
 Phe Arg Ala Tyr Gly Ile Glu Val Leu Thr Glu Ala Gln Val Val Thr
             260                 265                 270

 gtg gac gtg aga act aag aag gtc gtg ttc aag gat ggc ttc aag ctg      864
 Val Asp Val Arg Thr Lys Lys Val Val Phe Lys Asp Gly Phe Lys Leu
         275                 280                 285

 gag tac agc aag ctg ctg ctg gca cca ggg agc agc ccc aag act ctg      912
 Glu Tyr Ser Lys Leu Leu Leu Ala Pro Gly Ser Ser Pro Lys Thr Leu
     290                 295                 300

 agc tgc aaa ggc aaa gaa gtg gag aac gtg ttc act atc cgg acg cca      960
 Ser Cys Lys Gly Lys Glu Val Glu Asn Val Phe Thr Ile Arg Thr Pro
 305                 310                 315                 320

 gag gat gcc aat cgc gtg gtg agg ctg gcc cga ggc cgc aac gtg gtc     1008
 Glu Asp Ala Asn Arg Val Val Arg Leu Ala Arg Gly Arg Asn Val Val
                 325                 330                 335

 gtc gtg gga gcc ggc ttc ctg ggg atg gag gtg gcc gct tac ctg acg     1056
 Val Val Gly Ala Gly Phe Leu Gly Met Glu Val Ala Ala Tyr Leu Thr
             340                 345                 350

 gag aag gcc cac tct gtg tct gtg gtg gag ctg gag gag acg ccc ttc     1104
 Glu Lys Ala His Ser Val Ser Val Val Glu Leu Glu Glu Thr Pro Phe
         355                 360                 365

 agg agg ttc ctg ggg gag cgc gtg ggt cgt gcc ctc atg aag atg ttt     1152
 Arg Arg Phe Leu Gly Glu Arg Val Gly Arg Ala Leu Met Lys Met Phe
     370                 375                 380

 gag aac aac cgg gtg aag ttc tac atg cag acg gag gtg tct gag ctg     1200
 Glu Asn Asn Arg Val Lys Phe Tyr Met Gln Thr Glu Val Ser Glu Leu
 385                 390                 395                 400

 cgg ggc cag gag gga aag ctg aag gag gtt gtg ctg aag agc agc aag     1248
 Arg Gly Gln Glu Gly Lys Leu Lys Glu Val Val Leu Lys Ser Ser Lys
                 405                 410                 415

 gtc gtg cgg gct gac gtc tgc gtg gtg ggc att ggt gca gtg ccc gcc     1296
 Val Val Arg Ala Asp Val Cys Val Val Gly Ile Gly Ala Val Pro Ala
             420                 425                 430

 aca ggc ttc ctg agg caa agc ggc atc ggt ttg gat tcc cga ggc ttc     1344
 Thr Gly Phe Leu Arg Gln Ser Gly Ile Gly Leu Asp Ser Arg Gly Phe
         435                 440                 445

 atc cct gtc aac aag atg atg cag acc aat gtc cca ggc gtg ttt gca     1392
 Ile Pro Val Asn Lys Met Met Gln Thr Asn Val Pro Gly Val Phe Ala
     450                 455                 460

 gct ggc gat gct gtc acc ttc ccc ctt gcc tgg agg aac aac cgc aaa     1440
 Ala Gly Asp Ala Val Thr Phe Pro Leu Ala Trp Arg Asn Asn Arg Lys
 465                 470                 475                 480

 gtg aac att cca cat tgg cag atg gct cat gct cag ggg cgc gtg gca     1488
 Val Asn Ile Pro His Trp Gln Met Ala His Ala Gln Gly Arg Val Ala
                 485                 490                 495

 gcc cag aac atg ttg gcg cag gag gcg gag atg agc act gtg ccc tac     1536
 Ala Gln Asn Met Leu Ala Gln Glu Ala Glu Met Ser Thr Val Pro Tyr
             500                 505                 510

 ctc tgg acc gcc atg ttt ggc aag agc ctg cgc tac gcg ggc tac gga     1584
 Leu Trp Thr Ala Met Phe Gly Lys Ser Leu Arg Tyr Ala Gly Tyr Gly
         515                 520                 525

 gaa ggc ttc gac gac gtc atc atc cag ggg gat ctg gag gag ctg aag     1632
 Glu Gly Phe Asp Asp Val Ile Ile Gln Gly Asp Leu Glu Glu Leu Lys
     530                 535                 540

 ttt gtg gct ttt tac act aaa ggc gac gag gtg atc gcc gtg gcc agc     1680
 Phe Val Ala Phe Tyr Thr Lys Gly Asp Glu Val Ile Ala Val Ala Ser
 545                 550                 555                 560

 atg aac tac gat ccc att gtg tcc aag gtc gct gag gtg ctg gcc tca     1728
 Met Asn Tyr Asp Pro Ile Val Ser Lys Val Ala Glu Val Leu Ala Ser
                 565                 570                 575

 ggc cgt gcc atc cgg aag cgg gag gtg gag tga                         1761
 Gly Arg Ala Ile Arg Lys Arg Glu Val Glu 
             580                 585





      <210> 230
      <211> 1809
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (361)..(1755)

      <400> 230
 aacgccttta tcgatgtgct gatgctactc tgcttcttcg ctggaccggc aggccggtgc     60

 acactttgta ggagcgggct tgtcataatc ttcttatgta gccccagccc tagctcagca    120

 gcggagcccc tcaaacctcg ggaactcctc cctgcaaagg agccaggacg ccctccctca    180

 ggctgccttt aaccaggctt ggtgacaaag gacctccaca gagtaggcgg tcactgcctt    240

 agcagtgagg cctcagggcc cgggcaggca cagccagcgg gactcgaagc aggctggcgc    300

 cgaggctcgt gtagccgcct cacagctgca ggcggactgt aagtgcgcgc gcggtcgcac    360
                                                                 
 atg gca gcg cag ccg ccg agg cca gtg ggt gag agg agc atg ggg agc      408
 Met Ala Ala Gln Pro Pro Arg Pro Val Gly Glu Arg Ser Met Gly Ser
   1               5                  10                  15

 tcc cgg gag gcc gcc cgt gcg ccg gcc agg tcc ccg gct tgg gcc tcc      456
 Ser Arg Glu Ala Ala Arg Ala Pro Ala Arg Ser Pro Ala Trp Ala Ser
              20                  25                  30

 act cag gcc agt act ccg ggc gcg gcc ctg gcg gtc cag cgc gaa tct      504
 Thr Gln Ala Ser Thr Pro Gly Ala Ala Leu Ala Val Gln Arg Glu Ser
          35                  40                  45

 cca gaa tct ggt ctc cag aaa cat tat tct aat ctg tgt atg gaa aaa      552
 Pro Glu Ser Gly Leu Gln Lys His Tyr Ser Asn Leu Cys Met Glu Lys
      50                  55                  60

 tcc cag aaa att aat cct ttt ata ttg cat ata ctc caa gaa gtg gat      600
 Ser Gln Lys Ile Asn Pro Phe Ile Leu His Ile Leu Gln Glu Val Asp
  65                  70                  75                  80

 gaa gaa att aaa aag ggg cta gca gca gga atc aca tta aac att gct      648
 Glu Glu Ile Lys Lys Gly Leu Ala Ala Gly Ile Thr Leu Asn Ile Ala
                  85                  90                  95

 ggt aac aat cgc tta gtg cca gta gaa aga gtt aca ggt gaa gat ttt      696
 Gly Asn Asn Arg Leu Val Pro Val Glu Arg Val Thr Gly Glu Asp Phe
             100                 105                 110

 tgg att ctt tcc aaa att tta aag aat tgt ctg tat att aat ggt ttg      744
 Trp Ile Leu Ser Lys Ile Leu Lys Asn Cys Leu Tyr Ile Asn Gly Leu
         115                 120                 125

 gat gtt gga tat aac ctt cta tgt gat gtt ggt gca tac tat gct gcg      792
 Asp Val Gly Tyr Asn Leu Leu Cys Asp Val Gly Ala Tyr Tyr Ala Ala
     130                 135                 140

 aaa ctg ctt cag aaa caa ctt aat ctc att tac tta aac ctc atg ttt      840
 Lys Leu Leu Gln Lys Gln Leu Asn Leu Ile Tyr Leu Asn Leu Met Phe
 145                 150                 155                 160

 aat gat att ggg ccc gaa ggt gga gaa ttg att gct aaa gtg cta cat      888
 Asn Asp Ile Gly Pro Glu Gly Gly Glu Leu Ile Ala Lys Val Leu His
                 165                 170                 175

 aag aat cgg act ctg aaa tac cta aga atg act gga aac aaa att gaa      936
 Lys Asn Arg Thr Leu Lys Tyr Leu Arg Met Thr Gly Asn Lys Ile Glu
             180                 185                 190

 aat aaa ggt gga atg ttt ttt gct gca atg ctg caa att aat tca tca      984
 Asn Lys Gly Gly Met Phe Phe Ala Ala Met Leu Gln Ile Asn Ser Ser
         195                 200                 205

 tta gag aaa tta gat ctg ggt gac tgt gat ctg gga atg caa agt gtg     1032
 Leu Glu Lys Leu Asp Leu Gly Asp Cys Asp Leu Gly Met Gln Ser Val
     210                 215                 220

 ata gca ttt gct aca gta cta act caa aac caa gca att aag gca ata     1080
 Ile Ala Phe Ala Thr Val Leu Thr Gln Asn Gln Ala Ile Lys Ala Ile
 225                 230                 235                 240

 aac cta aac cga cct ata ctg tac agt gaa cag gaa gag tct aca gtc     1128
 Asn Leu Asn Arg Pro Ile Leu Tyr Ser Glu Gln Glu Glu Ser Thr Val
                 245                 250                 255

 cat gta ggc cgc atg ttg aaa gaa aat cac tgt ctt gtt gca cta cac     1176
 His Val Gly Arg Met Leu Lys Glu Asn His Cys Leu Val Ala Leu His
             260                 265                 270

 atg tgt aag cat gat ata aaa aac agt ggt ata caa cag tta tgt gat     1224
 Met Cys Lys His Asp Ile Lys Asn Ser Gly Ile Gln Gln Leu Cys Asp
         275                 280                 285

 gca ctg tat ctg aac agt agc ctg cgc tac ctt gat gtc agc tgc aac     1272
 Ala Leu Tyr Leu Asn Ser Ser Leu Arg Tyr Leu Asp Val Ser Cys Asn
     290                 295                 300

 aaa ata act cat gat gga atg gtg tat ttg gct gat gta ctg aaa agc     1320
 Lys Ile Thr His Asp Gly Met Val Tyr Leu Ala Asp Val Leu Lys Ser
 305                 310                 315                 320

 aac act acc ctg gaa gta ata gat ctt tcc ttt aac aga ata gaa aat     1368
 Asn Thr Thr Leu Glu Val Ile Asp Leu Ser Phe Asn Arg Ile Glu Asn
                 325                 330                 335

 gca ggc gca aac tat ctc agt gaa act ctt act tca cac aac agg agt     1416
 Ala Gly Ala Asn Tyr Leu Ser Glu Thr Leu Thr Ser His Asn Arg Ser
             340                 345                 350

 ctt aaa gcg ttg tca gta gtc agc aac aac ata gag gga gaa gga ctt     1464
 Leu Lys Ala Leu Ser Val Val Ser Asn Asn Ile Glu Gly Glu Gly Leu
         355                 360                 365

 gtt gca ctt tca caa tca atg aaa aca aat ctc act ttc tct cat atc     1512
 Val Ala Leu Ser Gln Ser Met Lys Thr Asn Leu Thr Phe Ser His Ile
     370                 375                 380

 tac att tgg gga aac aaa ttt gat gag gct acg tgt ata gca tat tca     1560
 Tyr Ile Trp Gly Asn Lys Phe Asp Glu Ala Thr Cys Ile Ala Tyr Ser
 385                 390                 395                 400

 gac tta att caa atg ggt tgt cta aaa cca gac aat aca gat gtg gag     1608
 Asp Leu Ile Gln Met Gly Cys Leu Lys Pro Asp Asn Thr Asp Val Glu
                 405                 410                 415

 cca ttt gtg gta gat gga cgt gta tat ctt gca gaa gtc tcc aat ggc     1656
 Pro Phe Val Val Asp Gly Arg Val Tyr Leu Ala Glu Val Ser Asn Gly
             420                 425                 430

 ctt aaa aag cat tat tat tgg aca tca act tat gga gaa tct tat gac     1704
 Leu Lys Lys His Tyr Tyr Trp Thr Ser Thr Tyr Gly Glu Ser Tyr Asp
         435                 440                 445

 cac tca tct aat gca ggt ttt gct ctt gtt cca gta ggt caa cag cca     1752
 His Ser Ser Asn Ala Gly Phe Ala Leu Val Pro Val Gly Gln Gln Pro
     450                 455                 460

 tga aaaa gtagctgtaa aataattttc atacacttgt cttattgttt cacagagatt     1809
 






      <210> 231
      <211> 450
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (36)..(275)

      <400> 231
 tcccgctccc gccccgcgcc caccccgcgc ccgcc   atg tcc gag atc ctg ccc      53
                                          Met Ser Glu Ile Leu Pro
                                            1               5

 tac agc gaa gac aag atg ggc cgc ttc ggc gca gac ccc gag ggc tcc      101
 Tyr Ser Glu Asp Lys Met Gly Arg Phe Gly Ala Asp Pro Glu Gly Ser
              10                  15                  20

 gac ctc tcc ttc agc tgc cgc ctg cag gac acc aac tcc ttc ttc gcg      149
 Asp Leu Ser Phe Ser Cys Arg Leu Gln Asp Thr Asn Ser Phe Phe Ala
          25                  30                  35

 ggc aac cag gcc aag cga ccc ccc aag ctg ggc cag atc ggc cga gcc      197
 Gly Asn Gln Ala Lys Arg Pro Pro Lys Leu Gly Gln Ile Gly Arg Ala
      40                  45                  50

 aag cga gtg gtg atc gag gat gac cgg ata gac gac gtg ctg aag ggg      245
 Lys Arg Val Val Ile Glu Asp Asp Arg Ile Asp Asp Val Leu Lys Gly
  55                  60                  65                  70

 atg ggg gag aag ccg ccg tcc gga gtg tag a cgcgccggct cgggcggcgg      296
 Met Gly Glu Lys Pro Pro Ser Gly Val 
                  75

 gctccgggcc cagcctcgca gcggccagga gcgcgggccg gcgatgcggc tgccggcgcc    356

 cccccgcccc ggcccaggcg cccgcgggcg ggggctgcag ggccgtgccg ccgccgccgc    416

 caggcactcc ggagctgtcc gcttcagcac cacg                                450




      <210> 232
      <211> 1871
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (120)..(1871)

      <400> 232
 ggtccctgga cgcgaacaga gatcccctga ttcagccacc cccagactga gccccgtaga     60

 gtgcgttctt accttcctgc cccgacgaag gtcccagaga cgctgcggac aacaccagc     119                                                                 
 atg tcg agc gag cag agc gcg ccg ggg gcc tca ccc agg gcc ccg cgt      167
 Met Ser Ser Glu Gln Ser Ala Pro Gly Ala Ser Pro Arg Ala Pro Arg
   1               5                  10                  15

 ccg ggg acc cag aag tct tct ggc gcg gtg acc aaa aag gga gag cgc      215
 Pro Gly Thr Gln Lys Ser Ser Gly Ala Val Thr Lys Lys Gly Glu Arg
              20                  25                  30

 gcg gcc aaa gag aag cca gcg acc gtt ctg cct ccc gtg ggg gag gag      263
 Ala Ala Lys Glu Lys Pro Ala Thr Val Leu Pro Pro Val Gly Glu Glu
          35                  40                  45

 gag ccc aaa agc cct gag gag tac cag tgc tcc ggg gtc ctc gag acc      311
 Glu Pro Lys Ser Pro Glu Glu Tyr Gln Cys Ser Gly Val Leu Glu Thr
      50                  55                  60

 gac ttc gcc gag ctc tgc acg cgg tgg ggc tac acg gac ttc ccc aaa      359
 Asp Phe Ala Glu Leu Cys Thr Arg Trp Gly Tyr Thr Asp Phe Pro Lys
  65                  70                  75                  80

 gtt gtc aac cgg ccc cgc ccc cac ccg ccc ttc gtc ccc tcc gcc tct      407
 Val Val Asn Arg Pro Arg Pro His Pro Pro Phe Val Pro Ser Ala Ser
                  85                  90                  95

 ttg tcg gaa aag gcc acc tta gac gat ccg cgg ctg tcg ggg tcc tgc      455
 Leu Ser Glu Lys Ala Thr Leu Asp Asp Pro Arg Leu Ser Gly Ser Cys
             100                 105                 110

 agc ctc aat agc ctg gag agc aaa tac gtg ttc ttc cgg ccc acc atc      503
 Ser Leu Asn Ser Leu Glu Ser Lys Tyr Val Phe Phe Arg Pro Thr Ile
         115                 120                 125

 cag gtg gag ctg gag cag gag gac agc aag tca gtg aag gaa atc tac      551
 Gln Val Glu Leu Glu Gln Glu Asp Ser Lys Ser Val Lys Glu Ile Tyr
     130                 135                 140

 atc cgc ggt tgg aag gtt gag gaa cgg att ctg ggt gtc ttc tct aaa      599
 Ile Arg Gly Trp Lys Val Glu Glu Arg Ile Leu Gly Val Phe Ser Lys
 145                 150                 155                 160

 tgt ctg ccc ccg ctt acc cag cta cag gcc atc aac ttg tgg aag gtg      647
 Cys Leu Pro Pro Leu Thr Gln Leu Gln Ala Ile Asn Leu Trp Lys Val
                 165                 170                 175

 ggg ctg acc gat aag acc ctg acc acc ttc atc gag ctc ctg cct ctc      695
 Gly Leu Thr Asp Lys Thr Leu Thr Thr Phe Ile Glu Leu Leu Pro Leu
             180                 185                 190

 tgt tca tcc acg ctc aga ggt tct cgc tct cct tcc tgg ctg cct ggg      743
 Cys Ser Ser Thr Leu Arg Gly Ser Arg Ser Pro Ser Trp Leu Pro Gly
         195                 200                 205

 gct ctg gcc ctg tac tgg ggg ctg atc tcc cct gcc ctc agg aag gtg      791
 Ala Leu Ala Leu Tyr Trp Gly Leu Ile Ser Pro Ala Leu Arg Lys Val
     210                 215                 220

 tct ctg gag ggg aac cca ctg ccg gag cag tcc tat cac aag ctc atg      839
 Ser Leu Glu Gly Asn Pro Leu Pro Glu Gln Ser Tyr His Lys Leu Met
 225                 230                 235                 240

 gcc ttg gac agc acg att gcg cac ttg tct ctg cgg aac aat aac atc      887
 Ala Leu Asp Ser Thr Ile Ala His Leu Ser Leu Arg Asn Asn Asn Ile
                 245                 250                 255

 gac gac cgc ggg gcg caa ctc ctg ggc cag gcg ctg tcc acg ctg cac      935
 Asp Asp Arg Gly Ala Gln Leu Leu Gly Gln Ala Leu Ser Thr Leu His
             260                 265                 270

 agc tgc aac cgg acc ctc gtc tcg ctc aac ctg ggt ttc aac cac atc      983
 Ser Cys Asn Arg Thr Leu Val Ser Leu Asn Leu Gly Phe Asn His Ile
         275                 280                 285

 ggt gac gag ggc gca ggc tac atc gcg gac ggc ctc cgg ctg aac cgt     1031
 Gly Asp Glu Gly Ala Gly Tyr Ile Ala Asp Gly Leu Arg Leu Asn Arg
     290                 295                 300

 tcc ctg ctc tgg ctg tcc ctg gcc cac aac cgc atc cag gac aag ggc     1079
 Ser Leu Leu Trp Leu Ser Leu Ala His Asn Arg Ile Gln Asp Lys Gly
 305                 310                 315                 320

 gcc ctg aag ctg gct gag gtc ctg cgc gcc ttc gag ctg aca cac acc     1127
 Ala Leu Lys Leu Ala Glu Val Leu Arg Ala Phe Glu Leu Thr His Thr
                 325                 330                 335

 gaa gtg gtg gag cgc cga cgc ctc ctg ctg gaa aaa ggg aca cag gag     1175
 Glu Val Val Glu Arg Arg Arg Leu Leu Leu Glu Lys Gly Thr Gln Glu
             340                 345                 350

 cgc tcg cga tcg ccc tcc tcc tct cga cac ggg gac tcc aaa acg gac     1223
 Arg Ser Arg Ser Pro Ser Ser Ser Arg His Gly Asp Ser Lys Thr Asp
         355                 360                 365

 cgt gag aag agt cag atg gta ggg atc agc aat agt gca ttg gtg gac     1271
 Arg Glu Lys Ser Gln Met Val Gly Ile Ser Asn Ser Ala Leu Val Asp
     370                 375                 380

 aag aca gac aag acg cag aca atg aaa acc cct aag ggc ctg ggc aag     1319
 Lys Thr Asp Lys Thr Gln Thr Met Lys Thr Pro Lys Gly Leu Gly Lys
 385                 390                 395                 400

 aaa aag gag aaa tca tgg gaa ttg gcc aag aaa gag gag aag ttg ggg     1367
 Lys Lys Glu Lys Ser Trp Glu Leu Ala Lys Lys Glu Glu Lys Leu Gly
                 405                 410                 415

 tct ggg cag tca ccc aca caa gga acc cct aag aag gaa gat gcc aca     1415
 Ser Gly Gln Ser Pro Thr Gln Gly Thr Pro Lys Lys Glu Asp Ala Thr
             420                 425                 430

 aag gca ggc aag ggg aag gta acc atc cct gaa cag aag cca agc agg     1463
 Lys Ala Gly Lys Gly Lys Val Thr Ile Pro Glu Gln Lys Pro Ser Arg
         435                 440                 445

 gca aaa ggg atc aag atc ggg agc aga gag aag cgc agc atc ctc ctg     1511
 Ala Lys Gly Ile Lys Ile Gly Ser Arg Glu Lys Arg Ser Ile Leu Leu
     450                 455                 460

 gag tcc gag ctg gtt gtt gag gct act gag gtg gtc aac cct ctc ctg     1559
 Glu Ser Glu Leu Val Val Glu Ala Thr Glu Val Val Asn Pro Leu Leu
 465                 470                 475                 480

 gag cct gtg gag cac cga gat ggg aaa gtt ttc atg cct ggg aac aag     1607
 Glu Pro Val Glu His Arg Asp Gly Lys Val Phe Met Pro Gly Asn Lys
                 485                 490                 495

 gtc ctt ttg cac ctc aac ctc atc cgg aac cgc atc aca gag gtg ggg     1655
 Val Leu Leu His Leu Asn Leu Ile Arg Asn Arg Ile Thr Glu Val Gly
             500                 505                 510

 ctg gag ggc ttc ctc gcc acg gtg cag tat cag atg cag ttc tcc aag     1703
 Leu Glu Gly Phe Leu Ala Thr Val Gln Tyr Gln Met Gln Phe Ser Lys
         515                 520                 525

 gcc aag agt gca tcc aag ggt cca gtg ggg ctg ctg tgg ctg tcc ctg     1751
 Ala Lys Ser Ala Ser Lys Gly Pro Val Gly Leu Leu Trp Leu Ser Leu
     530                 535                 540

 gct aaa aat tgc ttc gcc cca caa tgt cct gcg tac gcc ata atc cag     1799
 Ala Lys Asn Cys Phe Ala Pro Gln Cys Pro Ala Tyr Ala Ile Ile Gln
 545                 550                 555                 560

 gag ctg atg ttg cca agg gat ccc atc aag gcc aaa ctc agg gag gat     1847
 Glu Leu Met Leu Pro Arg Asp Pro Ile Lys Ala Lys Leu Arg Glu Asp
                 565                 570                 575

 gag gcc atg gca ttc ttc ccc tag                                     1871
 Glu Ala Met Ala Phe Phe Pro 
             580





      <210> 233
      <211> 705
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (290)..(658)

      <400> 233
 gggaacgatg actacaaaca agatggcctt ctcccccgac ccgacctcct tcccaggcac     60

 tcacacgccc tcctgtccac aaccctccgc gtgtgtggta cctgacggga gtcgcagtcc    120

 atctgctgcc ttcccgctgc catttctact cgtcaggaac aatggaaagg tgaaaaggaa    180

 agaggactac aagcaagatg gcggaagagg gacatacacc tgactagtag tcgatcttac    240

 gaggtgcgat gggattagta gttttatagc cttccagtgt tccttaaga    atg gcg     295
                                                          Met Ala
                                                            1

 gaa cca gga gga cga gga gac tac cgt aaa gat ggc agg cta cct agc      343
 Glu Pro Gly Gly Arg Gly Asp Tyr Arg Lys Asp Gly Arg Leu Pro Ser
           5                  10                  15

 ctc tcc cgg tct ccg ctt tcc acc acc ttg ggc acc tcg ccc gcc tgt      391
 Leu Ser Arg Ser Pro Leu Ser Thr Thr Leu Gly Thr Ser Pro Ala Cys
      20                  25                  30

 ggt ctc gaa atc ccc ccc acc agt ggc gca cgg cct gac ggg agt tgc      439
 Gly Leu Glu Ile Pro Pro Thr Ser Gly Ala Arg Pro Asp Gly Ser Cys
  35                  40                  45                  50

 agt ctc ccg gct ccc gtc tat cat ttc aag tcg aga caa tgg aag ggg      487
 Ser Leu Pro Ala Pro Val Tyr His Phe Lys Ser Arg Gln Trp Lys Gly
                  55                  60                  65

 atg ggg cgg ggc cac cgg caa aga tgg cgg ctg cag ggc cgg ggc gac      535
 Met Gly Arg Gly His Arg Gln Arg Trp Arg Leu Gln Gly Arg Gly Asp
              70                  75                  80

 tgc gac atg gga tgt gta gtc cag gcg tct ggc ctc ttc cct gcg gaa      583
 Cys Asp Met Gly Cys Val Val Gln Ala Ser Gly Leu Phe Pro Ala Glu
          85                  90                  95

 atg agg gag agg act acg aaa aag atg gcg acc tcg ccc ctc gac ctc      631
 Met Arg Glu Arg Thr Thr Lys Lys Met Ala Thr Ser Pro Leu Asp Leu
     100                 105                 110

 tgc gcc ggt gcc tgc tgg gaa atg tag ttcct tgccgagtcc aacagagaaa      683
 Cys Ala Gly Ala Cys Trp Glu Met 
 115                 120

 ggacgtcgct gttgaaatgt ga                                             705




      <210> 234
      <211> 552
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(552)

      <400> 234
  atg aag aag gtc aag aag aaa agg tca gag gcc aga cgc cac cga gac      48
  Met Lys Lys Val Lys Lys Lys Arg Ser Glu Ala Arg Arg His Arg Asp
    1               5                  10                  15

 tcc acc tcc cag cat gct agc tcc aat tcc acc tct cag cag cct agt       96
 Ser Thr Ser Gln His Ala Ser Ser Asn Ser Thr Ser Gln Gln Pro Ser
              20                  25                  30

 cct gaa tcc aca cca cag cag cct agc cct gaa tcc aca cca cag cat      144
 Pro Glu Ser Thr Pro Gln Gln Pro Ser Pro Glu Ser Thr Pro Gln His
          35                  40                  45

 tcc agc ctt gaa acc acc tcc cgg cag cca gca ttc caa gcc ctt cca      192
 Ser Ser Leu Glu Thr Thr Ser Arg Gln Pro Ala Phe Gln Ala Leu Pro
      50                  55                  60

 gca ccc gaa atc cgc cgc tcc tct tgc tgc ctt tta tct cca gat gct      240
 Ala Pro Glu Ile Arg Arg Ser Ser Cys Cys Leu Leu Ser Pro Asp Ala
  65                  70                  75                  80

 aac gtg aag gca gcc cct caa tcc agg aaa gca ggg cct ctg att cgc      288
 Asn Val Lys Ala Ala Pro Gln Ser Arg Lys Ala Gly Pro Leu Ile Arg
                  85                  90                  95

 gcc ggc ccg cat tcc tgc tcc tgt gcc act tgc ccc tgc agc tcc gct      336
 Ala Gly Pro His Ser Cys Ser Cys Ala Thr Cys Pro Cys Ser Ser Ala
             100                 105                 110

 tgc tgg cgt cgt ctg ggg cta tgc cat agc cgc atc ttc gat gtc ctt      384
 Cys Trp Arg Arg Leu Gly Leu Cys His Ser Arg Ile Phe Asp Val Leu
         115                 120                 125

 ctg cct cgg gac tgg cag atg gcg cca ggg aga gga ctc ccc aac ctg      432
 Leu Pro Arg Asp Trp Gln Met Ala Pro Gly Arg Gly Leu Pro Asn Leu
     130                 135                 140

 ctc acc ttc tac aga aaa tct tca aga aaa ccc tcc agt cat cgt aac      480
 Leu Thr Phe Tyr Arg Lys Ser Ser Arg Lys Pro Ser Ser His Arg Asn
 145                 150                 155                 160

 gcg tgt cct cca agc cct cgg aac tgt ggc tgt ggc tct ggg ggc tct      528
 Ala Cys Pro Pro Ser Pro Arg Asn Cys Gly Cys Gly Ser Gly Gly Ser
                 165                 170                 175

 agg agc tgc cta cta cat cac tga                                      552
 Arg Ser Cys Leu Leu His His 
             180





      <210> 235
      <211> 1350
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1350)

      <400> 235
  atg gct tta gac att ctc gcc atg gcc cct ttg tat cag gcc cct gcc      48
  Met Ala Leu Asp Ile Leu Ala Met Ala Pro Leu Tyr Gln Ala Pro Ala
    1               5                  10                  15

 atc aac aga ata ggg cca aag aca gac cca tct aaa agg cca gct gat       96
 Ile Asn Arg Ile Gly Pro Lys Thr Asp Pro Ser Lys Arg Pro Ala Asp
              20                  25                  30

 cca cta aaa ccc ttg gtt ctc tct agg acc aaa ctc acc acc att gag      144
 Pro Leu Lys Pro Leu Val Leu Ser Arg Thr Lys Leu Thr Thr Ile Glu
          35                  40                  45

 gcc aaa agg atc atg tcc atc ctg gat gag gcg atc tac aag gtg gag      192
 Ala Lys Arg Ile Met Ser Ile Leu Asp Glu Ala Ile Tyr Lys Val Glu
      50                  55                  60

 ctg gtg acc ttg ctg tcg tat gtg gca tcc aac aga gag gat atg gag      240
 Leu Val Thr Leu Leu Ser Tyr Val Ala Ser Asn Arg Glu Asp Met Glu
  65                  70                  75                  80

 ggg atg ctg ggg gag gac gtc atg agg gca gtg aga gag cat gag gat      288
 Gly Met Leu Gly Glu Asp Val Met Arg Ala Val Arg Glu His Glu Asp
                  85                  90                  95

 ctc tgc cag gtc ctc ctt gaa aac gtc agg tgc ctg aaa gag aaa gaa      336
 Leu Cys Gln Val Leu Leu Glu Asn Val Arg Cys Leu Lys Glu Lys Glu
             100                 105                 110

 agg caa ttg cag gag cag aaa gag gct gag gag gaa ggg tgg ctc aga      384
 Arg Gln Leu Gln Glu Gln Lys Glu Ala Glu Glu Glu Gly Trp Leu Arg
         115                 120                 125

 gac cgc ctc ctt tcc ata gag ctg cag aaa tcc agc ctc tca cca ctt      432
 Asp Arg Leu Leu Ser Ile Glu Leu Gln Lys Ser Ser Leu Ser Pro Leu
     130                 135                 140

 atg cag cag atc aaa gac tcc acc aag aac gtc ctt aga ctc ttg ctc      480
 Met Gln Gln Ile Lys Asp Ser Thr Lys Asn Val Leu Arg Leu Leu Leu
 145                 150                 155                 160

 agc aac ccc cag gct gct agg ctc ctg cag atg cag aca cag ggt aga      528
 Ser Asn Pro Gln Ala Ala Arg Leu Leu Gln Met Gln Thr Gln Gly Arg
                 165                 170                 175

 agt gca gaa gcc cag aat ttt att gac agc ctg ata gag ctc cgt ggt      576
 Ser Ala Glu Ala Gln Asn Phe Ile Asp Ser Leu Ile Glu Leu Arg Gly
             180                 185                 190

 ttc ctg ttt gaa aaa cta ctc act agt ccc atg gaa gcg agg gat aag      624
 Phe Leu Phe Glu Lys Leu Leu Thr Ser Pro Met Glu Ala Arg Asp Lys
         195                 200                 205

 gcc cag ttc tta cag gat atc agt aga cag aat agt aat aac caa caa      672
 Ala Gln Phe Leu Gln Asp Ile Ser Arg Gln Asn Ser Asn Asn Gln Gln
     210                 215                 220

 atc att gat act ctt gaa aag gaa ttg gcg gag aga atg aag aac agg      720
 Ile Ile Asp Thr Leu Glu Lys Glu Leu Ala Glu Arg Met Lys Asn Arg
 225                 230                 235                 240

 aat gca gag gtg gaa aag gag aac ttt gtg atc caa gaa ctg aaa aac      768
 Asn Ala Glu Val Glu Lys Glu Asn Phe Val Ile Gln Glu Leu Lys Asn
                 245                 250                 255

 cac ctg cac cag gtg ctc aag ttc tca gag aac agc ctc gtt cgc act      816
 His Leu His Gln Val Leu Lys Phe Ser Glu Asn Ser Leu Val Arg Thr
             260                 265                 270

 aag cag gag gct gag aag cag cag aag gcc gat ttc cgg gca tca cag      864
 Lys Gln Glu Ala Glu Lys Gln Gln Lys Ala Asp Phe Arg Ala Ser Gln
         275                 280                 285

 gcc agg gtg gcc aag atc cag cag gag atc ctg cag ctg cag tca cag      912
 Ala Arg Val Ala Lys Ile Gln Gln Glu Ile Leu Gln Leu Gln Ser Gln
     290                 295                 300

 ttt tac aac ctg gtc atg gag aac cgg gag gca gag cag gcg ctg agg      960
 Phe Tyr Asn Leu Val Met Glu Asn Arg Glu Ala Glu Gln Ala Leu Arg
 305                 310                 315                 320

 aag aag aaa tat aaa gtg gaa acg gaa atc gag aac tgg atc cag aaa     1008
 Lys Lys Lys Tyr Lys Val Glu Thr Glu Ile Glu Asn Trp Ile Gln Lys
                 325                 330                 335

 tat gat aca gag atg ggt gag aag cag gag gag ttg gag gat ctg gac     1056
 Tyr Asp Thr Glu Met Gly Glu Lys Gln Glu Glu Leu Glu Asp Leu Asp
             340                 345                 350

 gct gtt cac agg gag gag aag atc tcg ctg gag gag ctc agg cgg agg     1104
 Ala Val His Arg Glu Glu Lys Ile Ser Leu Glu Glu Leu Arg Arg Arg
         355                 360                 365

 cac aaa gtg ctg gtg gga gag ttt gcg cag atc cgg gaa gag cgg gag     1152
 His Lys Val Leu Val Gly Glu Phe Ala Gln Ile Arg Glu Glu Arg Glu
     370                 375                 380

 atc aac tcc aag aaa agg atg gag gca gag cag gag atg gtg cgc atg     1200
 Ile Asn Ser Lys Lys Arg Met Glu Ala Glu Gln Glu Met Val Arg Met
 385                 390                 395                 400

 gta cgg gcg gcc acg ctc atc cag gcc cta tgg aag ggc tat ctg gtg     1248
 Val Arg Ala Ala Thr Leu Ile Gln Ala Leu Trp Lys Gly Tyr Leu Val
                 405                 410                 415

 cgc tcc ctg ctc aga tcc aag aag aag cgg ggc aag ggc aaa gca aag     1296
 Arg Ser Leu Leu Arg Ser Lys Lys Lys Arg Gly Lys Gly Lys Ala Lys
             420                 425                 430

 gac aag gag aag ggc aag cag aaa ggc aag gag aag ggc aag ggc aag     1344
 Asp Lys Glu Lys Gly Lys Gln Lys Gly Lys Glu Lys Gly Lys Gly Lys
         435                 440                 445

 aaa tga                                                             1350
 Lys 






      <210> 236
      <211> 2497
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (494)..(2497)

      <400> 236
 ggattattct gtcaccaaat tatccagagg aatatgggaa caacatgaac tgtgtctggt     60

 tgattatctc ggagccagga agtcgaattc acctaatctt taatgatttt gatgttgagc    120

 ctcaatttga ctttctcgcg gtcaaggatg atggcatttc tgacataact gtcctgggta    180

 ctttttctgg caatgaagtg ccttcccagc tggccagcag tgggcatata gttcgcttgg    240

 aatttcagtc tgaccattcc actactggca gagggttcaa catcacttac accacatttg    300

 gccagaatga gtgccatgat cctggcattc ctataaacgg acgacgtttt ggtgacaggt    360

 ttctactcgg gagctcggtt tctttccact gtgatgatgg ctttgtcaag acccagggat    420

 ccgagtccat tacctgcata ctgcaagacg ggaacgtggt ctggagctcc accgtgcccc    480

 gctgtgaagc tcc   atg tgg tgg aca tct gac agc gtc cag cgg agt cat     529
                  Met Trp Trp Thr Ser Asp Ser Val Gln Arg Ser His
                    1               5                  10

 ttt gcc tcc tgg atg gcc aga tat tat aag gat tct tta cat tgt gaa      577
 Phe Ala Ser Trp Met Ala Arg Tyr Tyr Lys Asp Ser Leu His Cys Glu
          15                  20                  25

 tgg ata att gaa gca aaa cca ggc cac tct atc aaa ata act ttt gac      625
 Trp Ile Ile Glu Ala Lys Pro Gly His Ser Ile Lys Ile Thr Phe Asp
      30                  35                  40

 aga ttt cag aca gag gtc aat tat gac acc ttg gag gtc aga gat ggg      673
 Arg Phe Gln Thr Glu Val Asn Tyr Asp Thr Leu Glu Val Arg Asp Gly
  45                  50                  55                  60

 cca gcc agt tcg tcc cca ctg atc ggc gag tac cac ggc acc cag gca      721
 Pro Ala Ser Ser Ser Pro Leu Ile Gly Glu Tyr His Gly Thr Gln Ala
                  65                  70                  75

 ccc cag ttc ctc atc agc acc ggg aac ttc atg tac ctg ctg ttc acc      769
 Pro Gln Phe Leu Ile Ser Thr Gly Asn Phe Met Tyr Leu Leu Phe Thr
              80                  85                  90

 act gac aac agc cgc tcc agc atc ggc ttc ctc atc cac tat gag agt      817
 Thr Asp Asn Ser Arg Ser Ser Ile Gly Phe Leu Ile His Tyr Glu Ser
          95                 100                 105

 gtg acg ctt gag tcg gat tcc tgc ctg gac ccg ggc atc cct gtg aac      865
 Val Thr Leu Glu Ser Asp Ser Cys Leu Asp Pro Gly Ile Pro Val Asn
     110                 115                 120

 ggc cat cgc cac ggt gga gac ttt ggc atc agg tcc aca gtg act ttc      913
 Gly His Arg His Gly Gly Asp Phe Gly Ile Arg Ser Thr Val Thr Phe
 125                 130                 135                 140

 agc tgt gac ccg ggg tac aca cta agt gac gac gag ccc ctc gtc tgt      961
 Ser Cys Asp Pro Gly Tyr Thr Leu Ser Asp Asp Glu Pro Leu Val Cys
                 145                 150                 155

 gag agg aac cac cag tgg aac cac gcc ttg ccc agc tgc gac gct cta     1009
 Glu Arg Asn His Gln Trp Asn His Ala Leu Pro Ser Cys Asp Ala Leu
             160                 165                 170

 tgt gga ggc tac atc caa ggg aag agt gga aca gtc ctt tct cct ggg     1057
 Cys Gly Gly Tyr Ile Gln Gly Lys Ser Gly Thr Val Leu Ser Pro Gly
         175                 180                 185

 ttt cca gat ttt tat cca aac tct cta aac tgc acg tgg acc att gaa     1105
 Phe Pro Asp Phe Tyr Pro Asn Ser Leu Asn Cys Thr Trp Thr Ile Glu
     190                 195                 200

 gtg tct cat ggg aaa gga gtt caa atg atc ttt cac acc ttt cat ctt     1153
 Val Ser His Gly Lys Gly Val Gln Met Ile Phe His Thr Phe His Leu
 205                 210                 215                 220

 gag agt tcc cac gac tat tta ctg atc aca gag gat gga agt ttt tcc     1201
 Glu Ser Ser His Asp Tyr Leu Leu Ile Thr Glu Asp Gly Ser Phe Ser
                 225                 230                 235

 gag ccc gtt gcc agg ctc acc ggg tcg gtg ttg cct cat acg atc aag     1249
 Glu Pro Val Ala Arg Leu Thr Gly Ser Val Leu Pro His Thr Ile Lys
             240                 245                 250

 gca ggc ctg ttt gga aac ttc act gcc cag ctt cgg ttt ata tca gac     1297
 Ala Gly Leu Phe Gly Asn Phe Thr Ala Gln Leu Arg Phe Ile Ser Asp
         255                 260                 265

 ttc tca att tcg tac gag ggc ttc aat atc aca ttt tca gaa tat gac     1345
 Phe Ser Ile Ser Tyr Glu Gly Phe Asn Ile Thr Phe Ser Glu Tyr Asp
     270                 275                 280

 ctg gag cca tgt gat gat cct gga gtc cct gcc ttc agc cga aga att     1393
 Leu Glu Pro Cys Asp Asp Pro Gly Val Pro Ala Phe Ser Arg Arg Ile
 285                 290                 295                 300

 ggt ttt cac ttt ggt gtg gga gac tct ctg acg ttt tcc tgc ttc ctg     1441
 Gly Phe His Phe Gly Val Gly Asp Ser Leu Thr Phe Ser Cys Phe Leu
                 305                 310                 315

 gga tat cgt tta gaa ggt gcc acc aag ctt acc tgc ctg ggt ggg ggc     1489
 Gly Tyr Arg Leu Glu Gly Ala Thr Lys Leu Thr Cys Leu Gly Gly Gly
             320                 325                 330

 cgc cgt gtg tgg agt gca cct ctg cca agg tgt gtg gcc gaa tgt gga     1537
 Arg Arg Val Trp Ser Ala Pro Leu Pro Arg Cys Val Ala Glu Cys Gly
         335                 340                 345

 gca agt gtc aaa gga aat gaa gga aca tta ctg tct cca aat ttt cca     1585
 Ala Ser Val Lys Gly Asn Glu Gly Thr Leu Leu Ser Pro Asn Phe Pro
     350                 355                 360

 tcc aat tat gat aat aac cat gag tgt atc tat aaa ata gaa aca gaa     1633
 Ser Asn Tyr Asp Asn Asn His Glu Cys Ile Tyr Lys Ile Glu Thr Glu
 365                 370                 375                 380

 gcc ggc aag ggc atc cac ctt aga aca cga agc ttc cag ctg ttt gaa     1681
 Ala Gly Lys Gly Ile His Leu Arg Thr Arg Ser Phe Gln Leu Phe Glu
                 385                 390                 395

 gga gat act cta aag gta tat gat gga aaa gac agt tcc tca cgt cca     1729
 Gly Asp Thr Leu Lys Val Tyr Asp Gly Lys Asp Ser Ser Ser Arg Pro
             400                 405                 410

 ctg ggc acg ttc act aaa aat gaa ctt ctg ggg ctg atc cta aac agc     1777
 Leu Gly Thr Phe Thr Lys Asn Glu Leu Leu Gly Leu Ile Leu Asn Ser
         415                 420                 425

 aca tcc aat cac ctg tgg cta gag ttc aac acc aat gga tct gac acc     1825
 Thr Ser Asn His Leu Trp Leu Glu Phe Asn Thr Asn Gly Ser Asp Thr
     430                 435                 440

 gac caa ggt ttt caa ctc acc tat acc agt ttt gat ctg gta aaa tgt     1873
 Asp Gln Gly Phe Gln Leu Thr Tyr Thr Ser Phe Asp Leu Val Lys Cys
 445                 450                 455                 460

 gag gat ccg ggc atc cct aac tac ggc tat agg atc cgt gat gaa ggc     1921
 Glu Asp Pro Gly Ile Pro Asn Tyr Gly Tyr Arg Ile Arg Asp Glu Gly
                 465                 470                 475

 cac ttt acc gac act gta gtt ctg tac agt tgc aac ccg ggg tac gcc     1969
 His Phe Thr Asp Thr Val Val Leu Tyr Ser Cys Asn Pro Gly Tyr Ala
             480                 485                 490

 atg cat ggc agc aac acc ctg acc tgt ttg agt gga gac agg aga gtg     2017
 Met His Gly Ser Asn Thr Leu Thr Cys Leu Ser Gly Asp Arg Arg Val
         495                 500                 505

 tgg gac aaa cca cta cct tcg tgc ata gcg gaa tgt ggt ggt cag atc     2065
 Trp Asp Lys Pro Leu Pro Ser Cys Ile Ala Glu Cys Gly Gly Gln Ile
     510                 515                 520

 cat gca gcc aca tca gga cga ata ttg tcc cct ggc tat cca gct ccg     2113
 His Ala Ala Thr Ser Gly Arg Ile Leu Ser Pro Gly Tyr Pro Ala Pro
 525                 530                 535                 540

 tat gac aac aac ctc cac tgc acc tgg att ata gag gca gac cca gga     2161
 Tyr Asp Asn Asn Leu His Cys Thr Trp Ile Ile Glu Ala Asp Pro Gly
                 545                 550                 555

 aag acc att agc ctc cat ttc att gtt ttc gac acg gag atg gct cac     2209
 Lys Thr Ile Ser Leu His Phe Ile Val Phe Asp Thr Glu Met Ala His
             560                 565                 570

 gac atc ctc aag gtc tgg gac ggg ccg gtg gac agt gac atc ctg ctg     2257
 Asp Ile Leu Lys Val Trp Asp Gly Pro Val Asp Ser Asp Ile Leu Leu
         575                 580                 585

 aag gag tgg agt ggc tcc gcc ctt ccg gag gac atc cac agc acc ttc     2305
 Lys Glu Trp Ser Gly Ser Ala Leu Pro Glu Asp Ile His Ser Thr Phe
     590                 595                 600

 aac tca ctc acc ctg cag ttc gac agc gac ttc ttc atc agc aag tct     2353
 Asn Ser Leu Thr Leu Gln Phe Asp Ser Asp Phe Phe Ile Ser Lys Ser
 605                 610                 615                 620

 ggc ttc tcc atc cag ttc tcc agt ttc cga agg agg aag gag tgg aga     2401
 Gly Phe Ser Ile Gln Phe Ser Ser Phe Arg Arg Arg Lys Glu Trp Arg
                 625                 630                 635

 tat ttt gtg gca gtt cag cct ttt agt gcc ctt cgg atg gca ccg tgg     2449
 Tyr Phe Val Ala Val Gln Pro Phe Ser Ala Leu Arg Met Ala Pro Trp
             640                 645                 650

 aga gat gcc ata tta ttg ggc agc aca caa ggt cag cca tca tca taa     2497
 Arg Asp Ala Ile Leu Leu Gly Ser Thr Gln Gly Gln Pro Ser Ser 
         655                 660                 665





      <210> 237
      <211> 526
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (119)..(526)

      <400> 237
 cactacccga gcgctgttgc ctggagacca cgggacgccg ttgcctggag acagcgggga     60

 cgcgttgcct ggagactgtg gaaggcccag gcaagagggc gcgtggcagc ccaaggcc      118                                                                 
 atg gcg gga cac cca aaa gag aag gtg att cca gat gag gtc cat cag      166
 Met Ala Gly His Pro Lys Glu Lys Val Ile Pro Asp Glu Val His Gln
   1               5                  10                  15

 aac cag atc ttg cgg gaa ctg tac ctc aag gag cta cga acc cag aaa      214
 Asn Gln Ile Leu Arg Glu Leu Tyr Leu Lys Glu Leu Arg Thr Gln Lys
              20                  25                  30

 ctc tac acg cag tat cac gtg aat ccc ctc cgc aag att cat aca gtc      262
 Leu Tyr Thr Gln Tyr His Val Asn Pro Leu Arg Lys Ile His Thr Val
          35                  40                  45

 acc agg aag ccc atg tct tgg cat gat aac ctg gag gaa cct gca gat      310
 Thr Arg Lys Pro Met Ser Trp His Asp Asn Leu Glu Glu Pro Ala Asp
      50                  55                  60

 gcc agg ttt ctg aat ctc att cac cat gct gcc cag ggg cca acg aag      358
 Ala Arg Phe Leu Asn Leu Ile His His Ala Ala Gln Gly Pro Thr Lys
  65                  70                  75                  80

 aag tac ccg gag gca cag act gaa aac cag gaa att ggg tgg gac tca      406
 Lys Tyr Pro Glu Ala Gln Thr Glu Asn Gln Glu Ile Gly Trp Asp Ser
                  85                  90                  95

 gaa gcc ttg gtc gac cca gaa cgc cgt gac cac agg atg aac cac ttc      454
 Glu Ala Leu Val Asp Pro Glu Arg Arg Asp His Arg Met Asn His Phe
             100                 105                 110

 agg gtc tac agt gac atc act ctg tac aaa gct aaa atg tgg agc ttg      502
 Arg Val Tyr Ser Asp Ile Thr Leu Tyr Lys Ala Lys Met Trp Ser Leu
         115                 120                 125

 gga gaa gat gat cgc cac aag tag                                      526
 Gly Glu Asp Asp Arg His Lys 
     130                 135





      <210> 238
      <211> 3168
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (811)..(3168)

      <400> 238
 atggcccttt atagaggctg caagttgaag acagggggcc aggtctttga ggcctgcact     60

 gagcagtctt tggatatgga cttcccccgg ggagaagacg tgacttgtga gaggcagccc    120

 cctgcagtta ggacaactcc caaggaagta ttttgctgtg agccatcagc agccactcac    180

 ccggcagctg ctgggatgga tgcctcaacc ctgaaggagg atcctggcag caccacagtg    240

 tgcactatag ggcgtattaa gtttccagct ttggttgttg gtttatgttt tcctccctac    300

 aggcttgtga ttgctttgac caagagtctg acagaattgg tgttaggtga cttccaaggc    360

 catgttataa ttggccatgg cgcttctctc ttgttcactg gaatgctcac tcttggagcc    420

 cagagccacc atgtaacaag tccagctgcc ctcagtcctt tatgctggag agaccacatt    480

 gaggcactct ggtcaaacac aagccgagtt catcttttag cccatctcct cccaagcagt    540

 agacatggcc gctccggctg cccgtcggcc gggtcccagc gacaggtatt gatgtccggg    600

 cgcagcgcgc gagtgtccgc gcgatcagtg acagcccgag cccgtccacg cgcgggctcc    660

 cgtgctcgtg gcttgcggga gggcaaagac ggggtggagg ctgctgtggg cccagtccca    720

 gcgttgcgcg tcgcacggtc cccgactccc ccgctgccct cgacctcgac cctgcggctg    780

 aagaggacaa tgttagcctc aagcaagagg     atg aac agt tct tca cgt tct     831
                                      Met Asn Ser Ser Ser Arg Ser
                                        1               5

 caa atc ctt cta agg tgg aag tca gac aag gct cag agt gga ccc tac      879
 Gln Ile Leu Leu Arg Trp Lys Ser Asp Lys Ala Gln Ser Gly Pro Tyr
          10                  15                  20

 aat gtt gag aag gaa atc ctt act tca aga ttc ttg cgt gac act gag      927
 Asn Val Glu Lys Glu Ile Leu Thr Ser Arg Phe Leu Arg Asp Thr Glu
      25                  30                  35

 acc tgt cga cag aat ttt agg aat ttt cca tac cca gac ctg gct ggt      975
 Thr Cys Arg Gln Asn Phe Arg Asn Phe Pro Tyr Pro Asp Leu Ala Gly
  40                  45                  50                  55

 cct cga aag gca ttg agt caa ctc cga gag ctc tgc ctt aag tgg ctg     1023
 Pro Arg Lys Ala Leu Ser Gln Leu Arg Glu Leu Cys Leu Lys Trp Leu
                  60                  65                  70

 aga cct gag att cac tca aag gaa caa att ttg gag ctg ctg gtg ctg     1071
 Arg Pro Glu Ile His Ser Lys Glu Gln Ile Leu Glu Leu Leu Val Leu
              75                  80                  85

 gag caa ttc ctg acc atc ctg cct ggt gag gtt agg act tgg gta aag     1119
 Glu Gln Phe Leu Thr Ile Leu Pro Gly Glu Val Arg Thr Trp Val Lys
          90                  95                 100

 tcc cag tat cca gag agc agc gag gaa gca gtg act ctg gtg gag gat     1167
 Ser Gln Tyr Pro Glu Ser Ser Glu Glu Ala Val Thr Leu Val Glu Asp
     105                 110                 115

 ttg act cag att cta gaa gag gaa gct cct caa aac tct acc ctt tcc     1215
 Leu Thr Gln Ile Leu Glu Glu Glu Ala Pro Gln Asn Ser Thr Leu Ser
 120                 125                 130                 135

 caa gat acc cca gag gaa gac ccc aga gga aaa cat gct ttc cag aca     1263
 Gln Asp Thr Pro Glu Glu Asp Pro Arg Gly Lys His Ala Phe Gln Thr
                 140                 145                 150

 gga tgg cta aat gac ttg gtg acc aaa gaa tcg atg aca ttc aaa gat     1311
 Gly Trp Leu Asn Asp Leu Val Thr Lys Glu Ser Met Thr Phe Lys Asp
             155                 160                 165

 gtg gct gta gac atc acc cag gag gac tgg gag tta atg cgt cct gtg     1359
 Val Ala Val Asp Ile Thr Gln Glu Asp Trp Glu Leu Met Arg Pro Val
         170                 175                 180

 cag aag gaa tta tac aag act gtg acg tta cag aac tat tgg aac atg     1407
 Gln Lys Glu Leu Tyr Lys Thr Val Thr Leu Gln Asn Tyr Trp Asn Met
     185                 190                 195

 gtt tct ctg gga ctt aca gtg tac aga cca act gtg att ccc ata ttg     1455
 Val Ser Leu Gly Leu Thr Val Tyr Arg Pro Thr Val Ile Pro Ile Leu
 200                 205                 210                 215

 gaa gaa cca tgg atg gtg ata aaa gaa att tta gaa ggc cct agt cca     1503
 Glu Glu Pro Trp Met Val Ile Lys Glu Ile Leu Glu Gly Pro Ser Pro
                 220                 225                 230

 ggt gga gaa ggc atc gta aaa gaa ggc cta gag tct agg att agc atg     1551
 Gly Gly Glu Gly Ile Val Lys Glu Gly Leu Glu Ser Arg Ile Ser Met
             235                 240                 245

 gca tct aga gaa gat tat gaa gaa gta gtg gat aac ttt agg cca gaa     1599
 Ala Ser Arg Glu Asp Tyr Glu Glu Val Val Asp Asn Phe Arg Pro Glu
         250                 255                 260

 tgg gaa act aaa gcc caa gca tgt act cca gtg gag gat atg tct aaa     1647
 Trp Glu Thr Lys Ala Gln Ala Cys Thr Pro Val Glu Asp Met Ser Lys
     265                 270                 275

 ctc aca aag gaa gaa acc cat acc atc aaa tta gaa gac tca tat gac     1695
 Leu Thr Lys Glu Glu Thr His Thr Ile Lys Leu Glu Asp Ser Tyr Asp
 280                 285                 290                 295

 tac gat gat aga cta gag agg cga gga aaa ggt ggc ttc tgg aaa att     1743
 Tyr Asp Asp Arg Leu Glu Arg Arg Gly Lys Gly Gly Phe Trp Lys Ile
                 300                 305                 310

 cac act gat gaa aga ggt ttc agt ttg aag tca gtc ctt tca caa gaa     1791
 His Thr Asp Glu Arg Gly Phe Ser Leu Lys Ser Val Leu Ser Gln Glu
             315                 320                 325

 tat gat cct aca gaa gaa tgt ctt agt aaa tat gat ata tat aga aat     1839
 Tyr Asp Pro Thr Glu Glu Cys Leu Ser Lys Tyr Asp Ile Tyr Arg Asn
         330                 335                 340

 aat ttt gaa aag cat tca aac cta att gta cag ttt gat acc caa tta     1887
 Asn Phe Glu Lys His Ser Asn Leu Ile Val Gln Phe Asp Thr Gln Leu
     345                 350                 355

 gat aat aaa act tct gtg tat aat gaa ggc agg gca acc ttc aat cat     1935
 Asp Asn Lys Thr Ser Val Tyr Asn Glu Gly Arg Ala Thr Phe Asn His
 360                 365                 370                 375

 gtc tca tat ggt att gta cat agg aaa ata ctt cct gga gag aag cct     1983
 Val Ser Tyr Gly Ile Val His Arg Lys Ile Leu Pro Gly Glu Lys Pro
                 380                 385                 390

 tac aag tgt aat gtg tgt ggg aaa aaa ttt agg aaa tac cca tcc ctc     2031
 Tyr Lys Cys Asn Val Cys Gly Lys Lys Phe Arg Lys Tyr Pro Ser Leu
             395                 400                 405

 ctg aaa cac caa agt acc cat gcc aaa gag aaa tcg tat gaa tgt gaa     2079
 Leu Lys His Gln Ser Thr His Ala Lys Glu Lys Ser Tyr Glu Cys Glu
         410                 415                 420

 gaa tgt ggg aaa gag ttt agg cat atc tca tcc ctt att gca cat cag     2127
 Glu Cys Gly Lys Glu Phe Arg His Ile Ser Ser Leu Ile Ala His Gln
     425                 430                 435

 aga atg cac act gga gaa aaa cca tat gaa tgc cac cag tgt ggt aaa     2175
 Arg Met His Thr Gly Glu Lys Pro Tyr Glu Cys His Gln Cys Gly Lys
 440                 445                 450                 455

 gcc ttc agc cag cgt gca cac ctt act ata cat cag aga att cat act     2223
 Ala Phe Ser Gln Arg Ala His Leu Thr Ile His Gln Arg Ile His Thr
                 460                 465                 470

 gga gag aaa ccc tat aag tgt gat gac tgt ggg aaa gac ttc agt cag     2271
 Gly Glu Lys Pro Tyr Lys Cys Asp Asp Cys Gly Lys Asp Phe Ser Gln
             475                 480                 485

 cgt gca cac ctt acc atc cat caa agg aca cat act gga gag aaa cca     2319
 Arg Ala His Leu Thr Ile His Gln Arg Thr His Thr Gly Glu Lys Pro
         490                 495                 500

 tat aaa tgc ttg gaa tgt ggt aaa acc ttc agt cat agt tca tca ctg     2367
 Tyr Lys Cys Leu Glu Cys Gly Lys Thr Phe Ser His Ser Ser Ser Leu
     505                 510                 515

 att aat cat cag aga gtt cat act gga gaa aaa cct tat ata tgc aat     2415
 Ile Asn His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Ile Cys Asn
 520                 525                 530                 535

 gaa tgt ggg aag act ttc agt cag agt aca cac ctt ctt cag cat caa     2463
 Glu Cys Gly Lys Thr Phe Ser Gln Ser Thr His Leu Leu Gln His Gln
                 540                 545                 550

 aaa ata cat act ggg aag aaa cca tat aaa tgc aat gaa tgt tgg aaa     2511
 Lys Ile His Thr Gly Lys Lys Pro Tyr Lys Cys Asn Glu Cys Trp Lys
             555                 560                 565

 gtg ttt agt cag agt act tac ctt att cga cat cag aga att cat tct     2559
 Val Phe Ser Gln Ser Thr Tyr Leu Ile Arg His Gln Arg Ile His Ser
         570                 575                 580

 gga gag aag tgt tat aaa tgt aat gaa tgt gga aaa gcc ttt gct cat     2607
 Gly Glu Lys Cys Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Ala His
     585                 590                 595

 tcc tca acc ctt att caa cat caa acc act cac act gga gag aaa tcc     2655
 Ser Ser Thr Leu Ile Gln His Gln Thr Thr His Thr Gly Glu Lys Ser
 600                 605                 610                 615

 tat ata tgt aat ata tgt ggg aaa gcc ttc agc cag agt gca aat ctt     2703
 Tyr Ile Cys Asn Ile Cys Gly Lys Ala Phe Ser Gln Ser Ala Asn Leu
                 620                 625                 630

 act caa cat cat aga aca cat act gga gag aaa cca tat aaa tgc agt     2751
 Thr Gln His His Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Ser
             635                 640                 645

 gtg tgt ggg aaa gca ttc agc cag agt gtg cac ctt act caa cat cag     2799
 Val Cys Gly Lys Ala Phe Ser Gln Ser Val His Leu Thr Gln His Gln
         650                 655                 660

 agg att cat aat gga gaa aaa ccc ttt aaa tgc aat ata tgt ggg aaa     2847
 Arg Ile His Asn Gly Glu Lys Pro Phe Lys Cys Asn Ile Cys Gly Lys
     665                 670                 675

 gca tat aga caa ggc gca aat ctt act cag cat caa agg att cat act     2895
 Ala Tyr Arg Gln Gly Ala Asn Leu Thr Gln His Gln Arg Ile His Thr
 680                 685                 690                 695

 gga gaa aaa ccc tat aaa tgt aat gaa tgt ggg aaa gct ttc att tat     2943
 Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Ile Tyr
                 700                 705                 710

 tcc tca tca ctt aat caa cat cag aga act cat act gga gag aga ccc     2991
 Ser Ser Ser Leu Asn Gln His Gln Arg Thr His Thr Gly Glu Arg Pro
             715                 720                 725

 tat aaa tgt aat gaa tgt gat aag gat ttt agc cag aga aca tgc ctt     3039
 Tyr Lys Cys Asn Glu Cys Asp Lys Asp Phe Ser Gln Arg Thr Cys Leu
         730                 735                 740

 att caa cac cag aga att cac aca gga gag aaa ccc tat gca tgt cgt     3087
 Ile Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Ala Cys Arg
     745                 750                 755

 ata tgt ggt aaa acc ttc acc cag agt aca aac ctt att cag cat caa     3135
 Ile Cys Gly Lys Thr Phe Thr Gln Ser Thr Asn Leu Ile Gln His Gln
 760                 765                 770                 775

 cgt gtt cat aca ggt gcc aaa cat cgt aat taa                         3168
 Arg Val His Thr Gly Ala Lys His Arg Asn 
                 780                 785





      <210> 239
      <211> 791
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (88)..(741)

      <400> 239
 atgccccgcc ctggacaccc ccgcccagca tctgggcctc cacgcttggg accgtgggag     60

 cggcaacaga gctatgtctg gagacat    atg ata aac cac ctc agc ccc cac     111
                                  Met Ile Asn His Leu Ser Pro His
                                    1               5

 caa gcc gcc gca ccc gta gac cag acc cca agg acc ctg gcc acc atg      159
 Gln Ala Ala Ala Pro Val Asp Gln Thr Pro Arg Thr Leu Ala Thr Met
      10                  15                  20

 ggc cag aga gca tta cct tca tct ctg gct ctg ctg agc cgg ccc ttg      207
 Gly Gln Arg Ala Leu Pro Ser Ser Leu Ala Leu Leu Ser Arg Pro Leu
  25                  30                  35                  40

 agt ccc cca cct gct gcc tgc tct ggc gac cct ggg tgt ggg agt ggt      255
 Ser Pro Pro Pro Ala Ala Cys Ser Gly Asp Pro Gly Cys Gly Ser Gly
                  45                  50                  55

 gcc ggg ctg cct tct gct tcc gcc gct gcc ggg att gcc tcc agc gct      303
 Ala Gly Leu Pro Ser Ala Ser Ala Ala Ala Gly Ile Ala Ser Ser Ala
              60                  65                  70

 gtg gag cct gtg tgc ggg gat gca gcc cct gcc tgt cta ctg agg act      351
 Val Glu Pro Val Cys Gly Asp Ala Ala Pro Ala Cys Leu Leu Arg Thr
          75                  80                  85

 cca ctg agg gga ctg ctg aag cca act ggg cca agg agc aca atg gag      399
 Pro Leu Arg Gly Leu Leu Lys Pro Thr Gly Pro Arg Ser Thr Met Glu
      90                  95                 100

 tgc ccc cca gcc ctg atc gtg cac ccc cca gcc ggc ggg atg gcc agc      447
 Cys Pro Pro Ala Leu Ile Val His Pro Pro Ala Gly Gly Met Ala Ser
 105                 110                 115                 120

 ggc tca agt caa cca tgg gca gca gct tca gct acc ccg atg tta agc      495
 Gly Ser Ser Gln Pro Trp Ala Ala Ala Ser Ala Thr Pro Met Leu Ser
                 125                 130                 135

 tca aag gca tcc ctg tgt atc cct acc cga ggg cca cct ccc cag ccc      543
 Ser Lys Ala Ser Leu Cys Ile Pro Thr Arg Gly Pro Pro Pro Gln Pro
             140                 145                 150

 ctg atg cgg act cct gct gca agg agc cac tgg ccg atc ccc cac cca      591
 Leu Met Arg Thr Pro Ala Ala Arg Ser His Trp Pro Ile Pro His Pro
         155                 160                 165

 tgc gac aca gcc tgc cca gca cct ttg cca gta gtc ctc gtg gct ccg      639
 Cys Asp Thr Ala Cys Pro Ala Pro Leu Pro Val Val Leu Val Ala Pro
     170                 175                 180

 agg agt act att ctt tcc atg agt cgg acc tgg acc tgc cgg aga tgg      687
 Arg Ser Thr Ile Leu Ser Met Ser Arg Thr Trp Thr Cys Arg Arg Trp
 185                 190                 195                 200

 gca gtg gct cca tgt cga gcc gag aaa ttg atg tgc tca tct tca aga      735
 Ala Val Ala Pro Cys Arg Ala Glu Lys Leu Met Cys Ser Ser Ser Arg
                 205                 210                 215

 agc tga cagaggctgt tcagcgtaca ccagatcgat gagctggcca agtgccacat       791
 Ser 






      <210> 240
      <211> 4330
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (257)..(4276)

      <400> 240
 agcggtaagc gggaagcgag ggcgaggggt aggggctggg gaagggcgag cgggaggcgc     60

 gggctctctc tagcaggggg ctgcagccat gaagaggctc ttagctgccg ctggcaaggg    120

 cgtgcggggc ccggagcccc cgaacccctt cagcgaacgg gtctacactg agaaggacta    180

 cgggaccatc tacttcgggg atctagggaa gatccataaa gctgcctccc ggggacaagt    240

 ccggaagctg gagaag    atg aca aag agg aag aag acc atc aac ctt aat     289
                      Met Thr Lys Arg Lys Lys Thr Ile Asn Leu Asn
                        1               5                  10

 ata caa gac gcc cag aag agg act gct cta cac tgg gcc tgt gtc aat      337
 Ile Gln Asp Ala Gln Lys Arg Thr Ala Leu His Trp Ala Cys Val Asn
              15                  20                  25

 ggc cat gtg gaa gta gta aca ctt ctg gta gac aga aag tgc cag ctt      385
 Gly His Val Glu Val Val Thr Leu Leu Val Asp Arg Lys Cys Gln Leu
          30                  35                  40

 gat gtc ctt gat ggc gaa aac agg aca cct ctg atg aag gct cta caa      433
 Asp Val Leu Asp Gly Glu Asn Arg Thr Pro Leu Met Lys Ala Leu Gln
      45                  50                  55

 tgc cat cag gag gct tgt gca aat att ctg ata gat tct ggt gcc gat      481
 Cys His Gln Glu Ala Cys Ala Asn Ile Leu Ile Asp Ser Gly Ala Asp
  60                  65                  70                  75

 ata aat ctc gta gat gtg tat ggc aac atg gct ctc cat tat gct gtt      529
 Ile Asn Leu Val Asp Val Tyr Gly Asn Met Ala Leu His Tyr Ala Val
                  80                  85                  90

 tat agt gag att ttg tca gtg gtg gca aaa ctg ctg tcc cat ggt gca      577
 Tyr Ser Glu Ile Leu Ser Val Val Ala Lys Leu Leu Ser His Gly Ala
              95                 100                 105

 gtc atc gaa gtg cac aac aag gct agc ctc aca cca ctt tta cta gcc      625
 Val Ile Glu Val His Asn Lys Ala Ser Leu Thr Pro Leu Leu Leu Ala
         110                 115                 120

 ata acg aaa aga agc gag caa att gtg gaa ttt tta ctg aca aaa aat      673
 Ile Thr Lys Arg Ser Glu Gln Ile Val Glu Phe Leu Leu Thr Lys Asn
     125                 130                 135

 gca aat gca aat gca gtt aat aag tat aaa tgc aca gcc ctc atg ctt      721
 Ala Asn Ala Asn Ala Val Asn Lys Tyr Lys Cys Thr Ala Leu Met Leu
 140                 145                 150                 155

 gct gta tgt cat gga tca tca gag ata gtc ggc att ctt ctt cag caa      769
 Ala Val Cys His Gly Ser Ser Glu Ile Val Gly Ile Leu Leu Gln Gln
                 160                 165                 170

 aat att gac atc tgt gct gaa gat atg tgt gga atg act gca gaa cat      817
 Asn Ile Asp Ile Cys Ala Glu Asp Met Cys Gly Met Thr Ala Glu His
             175                 180                 185

 tat gct gtt act tgt gga ttt cat cac att cat gaa caa att atg gaa      865
 Tyr Ala Val Thr Cys Gly Phe His His Ile His Glu Gln Ile Met Glu
         190                 195                 200

 tat ata cga aaa tta tct aaa aat cat caa aat acc aat cca gaa gga      913
 Tyr Ile Arg Lys Leu Ser Lys Asn His Gln Asn Thr Asn Pro Glu Gly
     205                 210                 215

 aca tct gca gga aca cct gat gag gct gca ccc ttg gcg gaa aga aca      961
 Thr Ser Ala Gly Thr Pro Asp Glu Ala Ala Pro Leu Ala Glu Arg Thr
 220                 225                 230                 235

 cct gac aca gct gaa agc ttg gtg gaa aaa aca cct gat gag gct gca     1009
 Pro Asp Thr Ala Glu Ser Leu Val Glu Lys Thr Pro Asp Glu Ala Ala
                 240                 245                 250

 ccc ttg gcg gaa aga aca cct gac acg gct gaa agc ttg gtg gaa aaa     1057
 Pro Leu Ala Glu Arg Thr Pro Asp Thr Ala Glu Ser Leu Val Glu Lys
             255                 260                 265

 aca cct gat gag gct gca ccc ttg gtg gag gga aca tct gac aaa att     1105
 Thr Pro Asp Glu Ala Ala Pro Leu Val Glu Gly Thr Ser Asp Lys Ile
         270                 275                 280

 caa tgt ttg ggg aaa gca aca tct gga aag ttt gaa cag tca gca gaa     1153
 Gln Cys Leu Gly Lys Ala Thr Ser Gly Lys Phe Glu Gln Ser Ala Glu
     285                 290                 295

 gaa aca cct agg gaa att acg agt cct gca aaa gaa aca tct gag aaa     1201
 Glu Thr Pro Arg Glu Ile Thr Ser Pro Ala Lys Glu Thr Ser Glu Lys
 300                 305                 310                 315

 ttt acg tgg cca gca aaa gga aga cct agg aag atc gca tgg gag aaa     1249
 Phe Thr Trp Pro Ala Lys Gly Arg Pro Arg Lys Ile Ala Trp Glu Lys
                 320                 325                 330

 aaa gaa gac aca cct agg gaa att atg agt ccc gca aaa gaa aca tct     1297
 Lys Glu Asp Thr Pro Arg Glu Ile Met Ser Pro Ala Lys Glu Thr Ser
             335                 340                 345

 gag aaa ttt acg tgg gca gca aaa gga aga cct agg aag atc gca tgg     1345
 Glu Lys Phe Thr Trp Ala Ala Lys Gly Arg Pro Arg Lys Ile Ala Trp
         350                 355                 360

 gag aaa aaa gaa aca cct gta aag act gga tgc gtg gca aga gta aca     1393
 Glu Lys Lys Glu Thr Pro Val Lys Thr Gly Cys Val Ala Arg Val Thr
     365                 370                 375

 tct aat aaa act aaa gtt ttg gaa aaa gga aga tct aag atg att gca     1441
 Ser Asn Lys Thr Lys Val Leu Glu Lys Gly Arg Ser Lys Met Ile Ala
 380                 385                 390                 395

 tgt cct aca aaa gaa tca tct aca aaa gca agt gcc aat gat cag agg     1489
 Cys Pro Thr Lys Glu Ser Ser Thr Lys Ala Ser Ala Asn Asp Gln Arg
                 400                 405                 410

 ttc cca tca gaa tcc aaa caa gag gaa gat gaa gaa tat tct tgt gat     1537
 Phe Pro Ser Glu Ser Lys Gln Glu Glu Asp Glu Glu Tyr Ser Cys Asp
             415                 420                 425

 tct cgg agt ctc ttt gag agt tct gca aag att caa gtg tgt ata cct     1585
 Ser Arg Ser Leu Phe Glu Ser Ser Ala Lys Ile Gln Val Cys Ile Pro
         430                 435                 440

 gag tct ata tat caa aaa gta atg gag ata aat aga gaa gta gaa gag     1633
 Glu Ser Ile Tyr Gln Lys Val Met Glu Ile Asn Arg Glu Val Glu Glu
     445                 450                 455

 cct cct aag aag cca tct gcc ttc aag cct gcc att gaa atg caa aac     1681
 Pro Pro Lys Lys Pro Ser Ala Phe Lys Pro Ala Ile Glu Met Gln Asn
 460                 465                 470                 475

 tct gtt cca aat aaa gcc ttt gaa ttg aag aat gaa caa aca ttg aga     1729
 Ser Val Pro Asn Lys Ala Phe Glu Leu Lys Asn Glu Gln Thr Leu Arg
                 480                 485                 490

 gca gat ccg atg ttc cca cca gaa tcc aaa caa aag gac tat gaa gaa     1777
 Ala Asp Pro Met Phe Pro Pro Glu Ser Lys Gln Lys Asp Tyr Glu Glu
             495                 500                 505

 aat tct tgg gat tct gag agt ctc tgt gag act gtt tca cag aag gat     1825
 Asn Ser Trp Asp Ser Glu Ser Leu Cys Glu Thr Val Ser Gln Lys Asp
         510                 515                 520

 gtg tgt tta ccc aag gct aca cat caa aaa gaa ata gat aaa ata aat     1873
 Val Cys Leu Pro Lys Ala Thr His Gln Lys Glu Ile Asp Lys Ile Asn
     525                 530                 535

 gga aaa tta gaa gag tct cct aat aaa gat ggt ctt ctg aag gct acc     1921
 Gly Lys Leu Glu Glu Ser Pro Asn Lys Asp Gly Leu Leu Lys Ala Thr
 540                 545                 550                 555

 tgc gga atg aaa gtt tct att cca act aaa gcc tta gaa ttg aag gac     1969
 Cys Gly Met Lys Val Ser Ile Pro Thr Lys Ala Leu Glu Leu Lys Asp
                 560                 565                 570

 atg caa act ttc aaa gcg gag cct ccg ggg aag cca tct gcc ttc gag     2017
 Met Gln Thr Phe Lys Ala Glu Pro Pro Gly Lys Pro Ser Ala Phe Glu
             575                 580                 585

 cct gcc act gaa atg caa aag tct gtc cca aat aaa gcc ttg gaa ttg     2065
 Pro Ala Thr Glu Met Gln Lys Ser Val Pro Asn Lys Ala Leu Glu Leu
         590                 595                 600

 aaa aat gaa caa aca tgg aga gca gat gag ata ctc cca tca gaa tcc     2113
 Lys Asn Glu Gln Thr Trp Arg Ala Asp Glu Ile Leu Pro Ser Glu Ser
     605                 610                 615

 aaa caa aag gac tat gaa gaa aat tct tgg gat act gag agt ctc tgt     2161
 Lys Gln Lys Asp Tyr Glu Glu Asn Ser Trp Asp Thr Glu Ser Leu Cys
 620                 625                 630                 635

 gag act gtt tca cag aag gat gtg tgt tta ccc aag gct gcg cat caa     2209
 Glu Thr Val Ser Gln Lys Asp Val Cys Leu Pro Lys Ala Ala His Gln
                 640                 645                 650

 aaa gaa ata gat aaa ata aat gga aaa tta gaa ggg tct cct gtt aaa     2257
 Lys Glu Ile Asp Lys Ile Asn Gly Lys Leu Glu Gly Ser Pro Val Lys
             655                 660                 665

 gat ggt ctt ctg aag gct aac tgc gga atg aaa gtt tct att cca act     2305
 Asp Gly Leu Leu Lys Ala Asn Cys Gly Met Lys Val Ser Ile Pro Thr
         670                 675                 680

 aaa gcc tta gaa ttg atg gac atg caa act ttc aaa gca gag cct ccc     2353
 Lys Ala Leu Glu Leu Met Asp Met Gln Thr Phe Lys Ala Glu Pro Pro
     685                 690                 695

 gag aag cca tct gcc ttc gag cct gcc att gaa atg caa aag tct gtt     2401
 Glu Lys Pro Ser Ala Phe Glu Pro Ala Ile Glu Met Gln Lys Ser Val
 700                 705                 710                 715

 cca aat aaa gcc ttg gaa ttg aag aat gaa caa aca ttg aga gca gat     2449
 Pro Asn Lys Ala Leu Glu Leu Lys Asn Glu Gln Thr Leu Arg Ala Asp
                 720                 725                 730

 gag ata ctc cca tca gaa tcc aaa caa aag gac tat gaa gaa agt tct     2497
 Glu Ile Leu Pro Ser Glu Ser Lys Gln Lys Asp Tyr Glu Glu Ser Ser
             735                 740                 745

 tgg gat tct gag agt ctc tgt gag act gtt tca cag aag gat gtg tgt     2545
 Trp Asp Ser Glu Ser Leu Cys Glu Thr Val Ser Gln Lys Asp Val Cys
         750                 755                 760

 tta ccc aag gct aca cat caa aaa gaa ata gat aaa ata aat gga aaa     2593
 Leu Pro Lys Ala Thr His Gln Lys Glu Ile Asp Lys Ile Asn Gly Lys
     765                 770                 775

 tta gaa gag tct cct gat aat gat ggt ttt ctg aag gct ccc tgc aga     2641
 Leu Glu Glu Ser Pro Asp Asn Asp Gly Phe Leu Lys Ala Pro Cys Arg
 780                 785                 790                 795

 atg aaa gtt tct att cca act aaa gcc tta gaa ttg atg gac atg caa     2689
 Met Lys Val Ser Ile Pro Thr Lys Ala Leu Glu Leu Met Asp Met Gln
                 800                 805                 810

 act ttc aaa gca gag cct ccc gag aag cca tct gcc ttc gag cct gcc     2737
 Thr Phe Lys Ala Glu Pro Pro Glu Lys Pro Ser Ala Phe Glu Pro Ala
             815                 820                 825

 att gaa atg caa aag tct gtt cca aat aaa gcc ttg gaa ttg aag aat     2785
 Ile Glu Met Gln Lys Ser Val Pro Asn Lys Ala Leu Glu Leu Lys Asn
         830                 835                 840

 gaa caa aca ttg aga gca gat cag atg ttc cct tca gaa tca aaa caa     2833
 Glu Gln Thr Leu Arg Ala Asp Gln Met Phe Pro Ser Glu Ser Lys Gln
     845                 850                 855

 aag aag gtt gaa gaa aat tct tgg gat tct gag agt ctc cgt gag act     2881
 Lys Lys Val Glu Glu Asn Ser Trp Asp Ser Glu Ser Leu Arg Glu Thr
 860                 865                 870                 875

 gtt tca cag aag gat gtg tgt gta ccc aag gct aca cat caa aaa gaa     2929
 Val Ser Gln Lys Asp Val Cys Val Pro Lys Ala Thr His Gln Lys Glu
                 880                 885                 890

 atg gat aaa ata agt gga aaa tta gaa gat tca act agc cta tca aaa     2977
 Met Asp Lys Ile Ser Gly Lys Leu Glu Asp Ser Thr Ser Leu Ser Lys
             895                 900                 905

 atc ttg gat aca gtt cat tct tgt gaa aga gca agg gaa ctt caa aaa     3025
 Ile Leu Asp Thr Val His Ser Cys Glu Arg Ala Arg Glu Leu Gln Lys
         910                 915                 920

 gat cac tgt gaa caa cgt aca gga aaa atg gaa caa atg aaa aag aag     3073
 Asp His Cys Glu Gln Arg Thr Gly Lys Met Glu Gln Met Lys Lys Lys
     925                 930                 935

 ttt tgt gta ctg aaa aag aaa ctg tca gaa gca aaa gaa ata aaa tca     3121
 Phe Cys Val Leu Lys Lys Lys Leu Ser Glu Ala Lys Glu Ile Lys Ser
 940                 945                 950                 955

 cag tta gag aac caa aaa gtt aaa tgg gaa caa gag ctc tgc agt gtg     3169
 Gln Leu Glu Asn Gln Lys Val Lys Trp Glu Gln Glu Leu Cys Ser Val
                 960                 965                 970

 aga ttg act tta aac caa gaa gaa gag aag aga aga aat gcc gat ata     3217
 Arg Leu Thr Leu Asn Gln Glu Glu Glu Lys Arg Arg Asn Ala Asp Ile
             975                 980                 985

 tta aaa gaa aaa att agg gaa gaa tta gga aga atc gaa gag caa ctt     3265
 Leu Lys Glu Lys Ile Arg Glu Glu Leu Gly Arg Ile Glu Glu Gln Leu
         990                 995                1000

 agg aaa aag tta gaa gtg aaa caa caa ctt gaa cag gct ctc aga ata     3313
 Arg Lys Lys Leu Glu Val Lys Gln Gln Leu Glu Gln Ala Leu Arg Ile
    1005                1010                1015

 caa gat ata gaa ttg aaa agt gta aca agt aat ttg aat cag gtt tct     3361
 Gln Asp Ile Glu Leu Lys Ser Val Thr Ser Asn Leu Asn Gln Val Ser
1020                1025                1030                1035

 cac act cat gaa agt gaa aat gat ctc ttt cat gaa aat tgc atg ttg     3409
 His Thr His Glu Ser Glu Asn Asp Leu Phe His Glu Asn Cys Met Leu
                1040                1045                1050

 aaa aag gaa att gcc atg cta aaa ctg gaa gta gcc aca ctg aaa cat     3457
 Lys Lys Glu Ile Ala Met Leu Lys Leu Glu Val Ala Thr Leu Lys His
            1055                1060                1065

 caa cac cag gag aag gaa aat aaa tac ttt gag gac att aag att tta     3505
 Gln His Gln Glu Lys Glu Asn Lys Tyr Phe Glu Asp Ile Lys Ile Leu
        1070                1075                1080

 caa gaa aag aat gct gaa ctt caa atg acc cta aaa ctg aaa cag aaa     3553
 Gln Glu Lys Asn Ala Glu Leu Gln Met Thr Leu Lys Leu Lys Gln Lys
    1085                1090                1095

 aca tta aca aaa agg gca tct cag tat aga gag cag ctt aaa gtt ctg     3601
 Thr Leu Thr Lys Arg Ala Ser Gln Tyr Arg Glu Gln Leu Lys Val Leu
1100                1105                1110                1115

 aca gca gag aac acg atg ctg act tct aaa ttg aag gaa aaa caa gac     3649
 Thr Ala Glu Asn Thr Met Leu Thr Ser Lys Leu Lys Glu Lys Gln Asp
                1120                1125                1130

 aaa gaa ata ctg gag aca gaa att gaa tca cac cat cct aga ctg gct     3697
 Lys Glu Ile Leu Glu Thr Glu Ile Glu Ser His His Pro Arg Leu Ala
            1135                1140                1145

 tct gct tta caa gac cat gat caa agt gtc aca tca aga aaa aac caa     3745
 Ser Ala Leu Gln Asp His Asp Gln Ser Val Thr Ser Arg Lys Asn Gln
        1150                1155                1160

 gaa ctt gct ttc cac agt gca gga gat gct cat ttg caa gga ata atg     3793
 Glu Leu Ala Phe His Ser Ala Gly Asp Ala His Leu Gln Gly Ile Met
    1165                1170                1175

 aat gtt gat gtg agt aat aca ata tat aac aat gag gtg ctc cat caa     3841
 Asn Val Asp Val Ser Asn Thr Ile Tyr Asn Asn Glu Val Leu His Gln
1180                1185                1190                1195

 cca ctt tat gaa gct caa agg aaa tcc aaa agc cca aaa att aat ctc     3889
 Pro Leu Tyr Glu Ala Gln Arg Lys Ser Lys Ser Pro Lys Ile Asn Leu
                1200                1205                1210

 aat tat gca gga gat gat cta aga gaa aat gca ttg gtt tcg gaa cat     3937
 Asn Tyr Ala Gly Asp Asp Leu Arg Glu Asn Ala Leu Val Ser Glu His
            1215                1220                1225

 gca caa aga gac cga tgt gaa aca cag tgt caa atg aag aaa gct gaa     3985
 Ala Gln Arg Asp Arg Cys Glu Thr Gln Cys Gln Met Lys Lys Ala Glu
        1230                1235                1240

 cac atg tat caa aat gaa caa gat aat gtg gac aaa cac act gaa cag     4033
 His Met Tyr Gln Asn Glu Gln Asp Asn Val Asp Lys His Thr Glu Gln
    1245                1250                1255

 cag gag tct ctg gag cag aaa tta ttt caa cta gaa agc aaa aat agg     4081
 Gln Glu Ser Leu Glu Gln Lys Leu Phe Gln Leu Glu Ser Lys Asn Arg
1260                1265                1270                1275

 tgg ctt cga cag caa tta gtt tat gca cat aag aaa gtt aac aaa agc     4129
 Trp Leu Arg Gln Gln Leu Val Tyr Ala His Lys Lys Val Asn Lys Ser
                1280                1285                1290

 aag gta aca att aat att cag ttt cct gag acg aaa atg caa cgt cat     4177
 Lys Val Thr Ile Asn Ile Gln Phe Pro Glu Thr Lys Met Gln Arg His
            1295                1300                1305

 cta aaa gag aaa aat gag gag gta ttc aat tat ggt aac cat tta aaa     4225
 Leu Lys Glu Lys Asn Glu Glu Val Phe Asn Tyr Gly Asn His Leu Lys
        1310                1315                1320

 gaa cgt ata gat caa tat gaa aaa gag aaa gca gaa aga gaa aac tca     4273
 Glu Arg Ile Asp Gln Tyr Glu Lys Glu Lys Ala Glu Arg Glu Asn Ser
    1325                1330                1335

 tga gaga caagcagtaa gaaacttctt ttggagaaac aacagaccag atctttactc     4330
 






      <210> 241
      <211> 2168
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (630)..(1412)

      <400> 241
 tttgttagac tcttcaagag aggcttcctc ttgcttttca agggggaatt aaagataaac     60

 tagggacaat gaattttaag acctttcaaa gggtgtgata tctttgctgc tttcatttgg    120

 atttttaaaa atcccatgtt tccctttata attaacaaaa tccatgaatt aaaatgggtc    180

 tttgtgctaa tctttagggc agcaagaaat gaggctcttg agaaatagta ccccattttg    240

 ctatcacctt agatgttgga gagggaaaga gagggcgaga gagctgaaag aaatccttcg    300

 caagaaaaca aagtaagtgg acagagtagt tggcggggaa catctgggat tataaacact    360

 gggggcaaag acaagacctt gtgaaatgcc tgacatagta tctcacgaac ctgatgaata    420

 aaaccatgat atctgggtga ccctggtgac aacgctggga aaggtgagag gaaacagaga    480

 gcgctgtgtt tgagagtaat gttattggtt ctttaggaac gagaccgtgg gctcttagtg    540

 acgctgtggg ttcctgagtt gtctgggagt acagggactg cagcctcgag tctgtccagc    600

 tacgatcact ttggaaggcc ttcggtggg  atg cgg gca gaa agc tcc cag tgc     653
                                  Met Arg Ala Glu Ser Ser Gln Cys
                                    1               5

 aaa ggg cgt gcc acg aaa acc acc agc cag aaa cct gag ctg gga cag      701
 Lys Gly Arg Ala Thr Lys Thr Thr Ser Gln Lys Pro Glu Leu Gly Gln
      10                  15                  20

 agc ctg ggg tct cgg caa ctt ccg gcg gcg gga gct gca gag cgc aag      749
 Ser Leu Gly Ser Arg Gln Leu Pro Ala Ala Gly Ala Ala Glu Arg Lys
  25                  30                  35                  40

 gcg cgc cca ctg cgc gtg cgc ttc ggc ccg gct cct cct gcg ccc ccg      797
 Ala Arg Pro Leu Arg Val Arg Phe Gly Pro Ala Pro Pro Ala Pro Pro
                  45                  50                  55

 gcc cct gcg act ggg act tgg tac ggc cgg gcg gtt ggc gtc ctc tgc      845
 Ala Pro Ala Thr Gly Thr Trp Tyr Gly Arg Ala Val Gly Val Leu Cys
              60                  65                  70

 ggc tcc tgc cag ggg cgg gct ttt caa atc ttc cct ttg aag gag tgg      893
 Gly Ser Cys Gln Gly Arg Ala Phe Gln Ile Phe Pro Leu Lys Glu Trp
          75                  80                  85

 cga cgg ccc gga cag ttc gcg ttg gag atg gag ggg ccg agc ctg agg      941
 Arg Arg Pro Gly Gln Phe Ala Leu Glu Met Glu Gly Pro Ser Leu Arg
      90                  95                 100

 ggt cct gcg ctc cgc ctg gcg ggg ctt ccc acc cag cag gac tgc aac      989
 Gly Pro Ala Leu Arg Leu Ala Gly Leu Pro Thr Gln Gln Asp Cys Asn
 105                 110                 115                 120

 att caa gaa aaa ata gac tta gaa att cga atg cga gaa gga ata tgg     1037
 Ile Gln Glu Lys Ile Asp Leu Glu Ile Arg Met Arg Glu Gly Ile Trp
                 125                 130                 135

 aaa ctc ctt tct ctg agc act cag aaa gat caa gtt tta cat gca gtt     1085
 Lys Leu Leu Ser Leu Ser Thr Gln Lys Asp Gln Val Leu His Ala Val
             140                 145                 150

 aag aat ctc atg gtg tgc aat gct cga cta atg gcc tat aca tcg gag     1133
 Lys Asn Leu Met Val Cys Asn Ala Arg Leu Met Ala Tyr Thr Ser Glu
         155                 160                 165

 cta cag aaa tta gaa gaa cag att gca aat cag act gga aga tgt gat     1181
 Leu Gln Lys Leu Glu Glu Gln Ile Ala Asn Gln Thr Gly Arg Cys Asp
     170                 175                 180

 gtg aaa ttt gaa agt aaa gaa cga aca gca tgt aaa gga aag att gcc     1229
 Val Lys Phe Glu Ser Lys Glu Arg Thr Ala Cys Lys Gly Lys Ile Ala
 185                 190                 195                 200

 ata tca gat att cga ata cca cta atg tgg aaa gac tct gat cac ttc     1277
 Ile Ser Asp Ile Arg Ile Pro Leu Met Trp Lys Asp Ser Asp His Phe
                 205                 210                 215

 agc aat aaa gaa cga tca cga cgc tat gcc att ttt tgt tta ttc aaa     1325
 Ser Asn Lys Glu Arg Ser Arg Arg Tyr Ala Ile Phe Cys Leu Phe Lys
             220                 225                 230

 atg gga gct aat gtg ttt gat act gat gtg gtg aat gtg gat aaa aca     1373
 Met Gly Ala Asn Val Phe Asp Thr Asp Val Val Asn Val Asp Lys Thr
         235                 240                 245

 atc aca gat ata tgt ttt gaa aat gta acc ata ttg taa gtatttttta      1422
 Ile Thr Asp Ile Cys Phe Glu Asn Val Thr Ile Leu 
     250                 255                 260

 atcttcagag aataaaaata atttaaaatt cttctttttt aaaagaaagt tcttattatt   1482

 ggttctttgg attcatttta tgtttaaatg tttaagtgat ctttaaatgt ttaatatgat   1542

 tttaaaaatt attttgttca gaagaagtcc atttctctat ctgcagtttt ctgatgtgaa   1602

 ataaaaatgg aaatcttgta attactatta gcagtaaata tttgacttat tagatatgac   1662

 ccatttttaa attgttaata aatatagttc agttattaac aaagctatgc atacaacaga   1722

 atatcctgta atgttatttg atatagagag aatttaagca taaaacagga ttttgatctc   1782

 atgtaggata tttggtctgc agaaatacta aaatagtata gcaactttat ttacaagaat   1842

 agtcctgaag tacatgctat attaggaaga gcactttgca aattgagggg tgatcttttc   1902

 ttcatggtgc accttccttt catggttctt tccaaagcaa ctacacccca accagcgggt   1962

 aatctcaggg ggcctggttt accacttgcg gtcccgggcc cctttaacag gggcccattc   2022

 actagggcgg catctcatta ccagaacaag caagcagaat cccctgggta tatccccaca   2082

 caaactctcg tctttacgtc acacatgatc ttacccggcc ctcatcaaaa ggcacataat   2142

 agccgaaacc acacgggaca acgtac                                        2168




      <210> 242
      <211> 936
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(936)

      <400> 242
  atg gca agg ccg cag ccg tgc ggg ccc ccg cac gct agg tgc ggc tcg      48
  Met Ala Arg Pro Gln Pro Cys Gly Pro Pro His Ala Arg Cys Gly Ser
    1               5                  10                  15

 ccg tcg ctg ccg gag cgg ccg ctg cag gtg aag gtg gtg ggg ctc ttc       96
 Pro Ser Leu Pro Glu Arg Pro Leu Gln Val Lys Val Val Gly Leu Phe
              20                  25                  30

 agc tgc ccc aac ttt cag att gcg aag agc gcc gct gag aat ctg aag      144
 Ser Cys Pro Asn Phe Gln Ile Ala Lys Ser Ala Ala Glu Asn Leu Lys
          35                  40                  45

 aat aat cat cca tcc aaa ttt gaa gat cct ata tta gtt cct ctt caa      192
 Asn Asn His Pro Ser Lys Phe Glu Asp Pro Ile Leu Val Pro Leu Gln
      50                  55                  60

 gaa ttt gca tgg cat caa tat cta cag gag aaa aaa agg gaa ctc aaa      240
 Glu Phe Ala Trp His Gln Tyr Leu Gln Glu Lys Lys Arg Glu Leu Lys
  65                  70                  75                  80

 aat gaa acc tgg gaa tat tct tcc tct gtg att tct ttt gtt aat ggt      288
 Asn Glu Thr Trp Glu Tyr Ser Ser Ser Val Ile Ser Phe Val Asn Gly
                  85                  90                  95

 cag ttt ctg ggt gat gca ttg gat ctg cag aaa tgg gcc cac gag gtg      336
 Gln Phe Leu Gly Asp Ala Leu Asp Leu Gln Lys Trp Ala His Glu Val
             100                 105                 110

 tgg gat ata gtt gac att aaa ccc tct gca ctt tat gac gca ctc act      384
 Trp Asp Ile Val Asp Ile Lys Pro Ser Ala Leu Tyr Asp Ala Leu Thr
         115                 120                 125

 gag gat ttt tcc gct aag ttc tta aga gac acc aag cat gat ttc gtg      432
 Glu Asp Phe Ser Ala Lys Phe Leu Arg Asp Thr Lys His Asp Phe Val
     130                 135                 140

 ttt ttg gac att tgt att gat tct tct cca att gga aga ttg att ttt      480
 Phe Leu Asp Ile Cys Ile Asp Ser Ser Pro Ile Gly Arg Leu Ile Phe
 145                 150                 155                 160

 gag cta tac tgt gat gtg tgt ccc aaa aca tgt aaa aat ttt cag gtc      528
 Glu Leu Tyr Cys Asp Val Cys Pro Lys Thr Cys Lys Asn Phe Gln Val
                 165                 170                 175

 ttg tgc aca gga aaa gca ggg ttt tct caa cgt ggc ata aga cta cat      576
 Leu Cys Thr Gly Lys Ala Gly Phe Ser Gln Arg Gly Ile Arg Leu His
             180                 185                 190

 tac aaa aat tcc att ttt cat cga ata gta cag aat ggc tgg ata caa      624
 Tyr Lys Asn Ser Ile Phe His Arg Ile Val Gln Asn Gly Trp Ile Gln
         195                 200                 205

 gga ggg gat ata gtg tat gga aaa gga gat aat gga gag tcg att tat      672
 Gly Gly Asp Ile Val Tyr Gly Lys Gly Asp Asn Gly Glu Ser Ile Tyr
     210                 215                 220

 ggt cca aca ttt gaa gat gaa aac ttt tca gtt cct cat aat aaa aga      720
 Gly Pro Thr Phe Glu Asp Glu Asn Phe Ser Val Pro His Asn Lys Arg
 225                 230                 235                 240

 gga gta ctt gga atg gcc aac aaa ggc cgt cac agc aac ggg tca caa      768
 Gly Val Leu Gly Met Ala Asn Lys Gly Arg His Ser Asn Gly Ser Gln
                 245                 250                 255

 ttc tat atc aca ctg caa gca act cct tat cta gat aga aaa ttt gtg      816
 Phe Tyr Ile Thr Leu Gln Ala Thr Pro Tyr Leu Asp Arg Lys Phe Val
             260                 265                 270

 gct ttt ggg caa ctg att gaa gga aca gaa gtg ctt aaa caa cta gaa      864
 Ala Phe Gly Gln Leu Ile Glu Gly Thr Glu Val Leu Lys Gln Leu Glu
         275                 280                 285

 tta gtt cca aca cag aat gaa aga cca ata cat atg tgt aga att act      912
 Leu Val Pro Thr Gln Asn Glu Arg Pro Ile His Met Cys Arg Ile Thr
     290                 295                 300

 gac agt gga gat cct tat gct tga                                      936
 Asp Ser Gly Asp Pro Tyr Ala 
 305                 310





      <210> 243
      <211> 958
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (8)..(718)

      <400> 243
 tcccacc  atg gcg gag acc aag ctc cag ctg ttt gtc aag gcg agt gag      49
          Met Ala Glu Thr Lys Leu Gln Leu Phe Val Lys Ala Ser Glu
            1               5                  10

 gac ggg gag agc gtg ggt cac tgc ccc tcc tgc cag cgg ctc ttc atg       97
 Asp Gly Glu Ser Val Gly His Cys Pro Ser Cys Gln Arg Leu Phe Met
  15                  20                  25                  30

 gtc ctg ctc ctc aag ggc gta cct ttc acc ctc acc acg gtg gac acg      145
 Val Leu Leu Leu Lys Gly Val Pro Phe Thr Leu Thr Thr Val Asp Thr
                  35                  40                  45

 cgc agg tcc ccg gac gtg ctg aag gac ttc gcc ccc ggc tcg cag ctg      193
 Arg Arg Ser Pro Asp Val Leu Lys Asp Phe Ala Pro Gly Ser Gln Leu
              50                  55                  60

 ccc atc ctg ctc tat gac agc gac gcc aag aca gac acg ctg cag atc      241
 Pro Ile Leu Leu Tyr Asp Ser Asp Ala Lys Thr Asp Thr Leu Gln Ile
          65                  70                  75

 gag gac ttt ctg gag gag acg ctg ggg ccg ccc gac ttc ccc agc ctg      289
 Glu Asp Phe Leu Glu Glu Thr Leu Gly Pro Pro Asp Phe Pro Ser Leu
      80                  85                  90

 gcg cct cgt tac agg gag tcc aac acc gcc ggc aac gac gtt ttc cac      337
 Ala Pro Arg Tyr Arg Glu Ser Asn Thr Ala Gly Asn Asp Val Phe His
  95                 100                 105                 110

 aag ttc tcc gcg ttc atc aag aac ccg gtg ccc gcg cag gac gaa gcc      385
 Lys Phe Ser Ala Phe Ile Lys Asn Pro Val Pro Ala Gln Asp Glu Ala
                 115                 120                 125

 ctg tac cag cag ctg ctg cgc gcc ctc gcc agg ctg gac agc tac ctg      433
 Leu Tyr Gln Gln Leu Leu Arg Ala Leu Ala Arg Leu Asp Ser Tyr Leu
             130                 135                 140

 cgc gcg ccc ctg gag cac gag ctg gcg ggg gag ccg cag ctg cgc gag      481
 Arg Ala Pro Leu Glu His Glu Leu Ala Gly Glu Pro Gln Leu Arg Glu
         145                 150                 155

 tcc cgc cgc cgc ttc ctg gac ggc gac agg ctc acg ctg gcc gac tgc      529
 Ser Arg Arg Arg Phe Leu Asp Gly Asp Arg Leu Thr Leu Ala Asp Cys
     160                 165                 170

 agc ctc ctg ccc aag ctg cac atc gtc gac acg gtg tgc gcg cac ttc      577
 Ser Leu Leu Pro Lys Leu His Ile Val Asp Thr Val Cys Ala His Phe
 175                 180                 185                 190

 cgc cag gcg ccc atc ccc gcg gag ctg cgc ggc gta cgc cgc tac ctg      625
 Arg Gln Ala Pro Ile Pro Ala Glu Leu Arg Gly Val Arg Arg Tyr Leu
                 195                 200                 205

 gac agc gcg atg cag gag aaa gag ttc aaa tac acg tgt ccg cac agc      673
 Asp Ser Ala Met Gln Glu Lys Glu Phe Lys Tyr Thr Cys Pro His Ser
             210                 215                 220

 gcc gag atc ctg gcg gcc tac cgg ccc gcc gtg cac ccc cgc tag cgc      721
 Ala Glu Ile Leu Ala Ala Tyr Arg Pro Ala Val His Pro Arg 
         225                 230                 235

 cccaccccgc gtctgtcgcc caataaaggc atcttttgct cgggcacacc acaacaccac    781

 caagacaaga acgaacatcc ctgaagcaac tacatgcagg gactggcggc aacaagcgcg    841

 ccaagcgcac acgggcccag gggcagaaag caggctgcgg aaccccagtc tcgggtgaca    901

 cacggggaaa ctgagcgggc ccccaatagg gagcgacaaa acccaacgcc agtacgt       958




      <210> 244
      <211> 2028
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (49)..(1545)

      <400> 244
 ctccggcccc gttcgccccg tccggggccc cagtgcggcg ggacgctg atg tct ctg      57
                                                      Met Ser Leu
                                                        1

 ggc ccc cgg ccc gcg cct cta gcg tgc ccc tcc cgg ccc cgg gcc ctg      105
 Gly Pro Arg Pro Ala Pro Leu Ala Cys Pro Ser Arg Pro Arg Ala Leu
       5                  10                  15

 gcc ccg tcg cac gcg tgg gaa agt tgg cct gga acc ggc ccg acc agt      153
 Ala Pro Ser His Ala Trp Glu Ser Trp Pro Gly Thr Gly Pro Thr Ser
  20                  25                  30                  35

 tcc gcc cgg gcg cga gga ccg gcc gca gga agt tgc tgc aaa act ttt      201
 Ser Ala Arg Ala Arg Gly Pro Ala Ala Gly Ser Cys Cys Lys Thr Phe
                  40                  45                  50

 ttg ggg ggt gca gcc cgt gcc ccc cgc gcg ccg ggg ccg aat gcg cgc      249
 Leu Gly Gly Ala Ala Arg Ala Pro Arg Ala Pro Gly Pro Asn Ala Arg
              55                  60                  65

 cgc gta ggg tcc ccc ggg ccg aga ggg gtg ccc gga ggg aag agc gcg      297
 Arg Val Gly Ser Pro Gly Pro Arg Gly Val Pro Gly Gly Lys Ser Ala
          70                  75                  80

 gtg ggg gcg ccc cgg ccc cgc tgc cct ggg gct atg gcc atg gtg acc      345
 Val Gly Ala Pro Arg Pro Arg Cys Pro Gly Ala Met Ala Met Val Thr
      85                  90                  95

 ggc ggc tgg ggc ggc ccc ggc ggc gac acg aac ggc gtg gac aag gcg      393
 Gly Gly Trp Gly Gly Pro Gly Gly Asp Thr Asn Gly Val Asp Lys Ala
 100                 105                 110                 115

 ggc ggc tac ccg cgc gcg gcc gag gac gac tcg gcc tcg ccc ccc ggt      441
 Gly Gly Tyr Pro Arg Ala Ala Glu Asp Asp Ser Ala Ser Pro Pro Gly
                 120                 125                 130

 gcc gcc agc gac gcc gag ccg ggc gac gag gag cgg ccg ggg ctg cag      489
 Ala Ala Ser Asp Ala Glu Pro Gly Asp Glu Glu Arg Pro Gly Leu Gln
             135                 140                 145

 gtg gac tgc gtg gtg tgc ggg gac aag tcg agc ggc aag cat tac ggt      537
 Val Asp Cys Val Val Cys Gly Asp Lys Ser Ser Gly Lys His Tyr Gly
         150                 155                 160

 gtc ttc acc tgc gag ggc tgc aag agc ttt ttc aag cga agc atc cgc      585
 Val Phe Thr Cys Glu Gly Cys Lys Ser Phe Phe Lys Arg Ser Ile Arg
     165                 170                 175

 cgc aac ctc agc tac acc tgc cgg tcc aac cgt gac tgc cag atc gac      633
 Arg Asn Leu Ser Tyr Thr Cys Arg Ser Asn Arg Asp Cys Gln Ile Asp
 180                 185                 190                 195

 cag cac cac cgg aac cag tgc cag tac tgc cgt ctc aag aag tgc ttc      681
 Gln His His Arg Asn Gln Cys Gln Tyr Cys Arg Leu Lys Lys Cys Phe
                 200                 205                 210

 cgg gtg ggc atg agg aag gag gcg gtg cag cgc ggc cgc atc ccg cac      729
 Arg Val Gly Met Arg Lys Glu Ala Val Gln Arg Gly Arg Ile Pro His
             215                 220                 225

 tcg ctg cct ggt gcc gtg gcc gcc tcc tcg ggc agc ccc ccg ggc tcg      777
 Ser Leu Pro Gly Ala Val Ala Ala Ser Ser Gly Ser Pro Pro Gly Ser
         230                 235                 240

 gcg ctg gcg gca gtg gcg agc ggc gga gac ctc ttc ccg ggg cag ccg      825
 Ala Leu Ala Ala Val Ala Ser Gly Gly Asp Leu Phe Pro Gly Gln Pro
     245                 250                 255

 gtg tcc gaa ctg atc gcg cag ctg ctg cgc gct gag ccc tac cct gcg      873
 Val Ser Glu Leu Ile Ala Gln Leu Leu Arg Ala Glu Pro Tyr Pro Ala
 260                 265                 270                 275

 gcg gcc gga cgc ttc ggc gca ggg ggc ggc gcg gcg ggc gcg gtg ctg      921
 Ala Ala Gly Arg Phe Gly Ala Gly Gly Gly Ala Ala Gly Ala Val Leu
                 280                 285                 290

 ggc atc gac aac gtg tgc gag ctg gcg gcg cgg ctg ctc ttc agc acc      969
 Gly Ile Asp Asn Val Cys Glu Leu Ala Ala Arg Leu Leu Phe Ser Thr
             295                 300                 305

 gtg gag tgg gcg cgc cac gcg ccc ttc ttc ccc gag ctg ccg gtg gcc     1017
 Val Glu Trp Ala Arg His Ala Pro Phe Phe Pro Glu Leu Pro Val Ala
         310                 315                 320

 gac cag gtg gcg ctg ctg cgc ctg agc tgg agc gag ctc ttc gtg ctg     1065
 Asp Gln Val Ala Leu Leu Arg Leu Ser Trp Ser Glu Leu Phe Val Leu
     325                 330                 335

 aac gcg gcg cag gcg gcg ctg ccc ctg cac acg gcg ccg cta ctg gcc     1113
 Asn Ala Ala Gln Ala Ala Leu Pro Leu His Thr Ala Pro Leu Leu Ala
 340                 345                 350                 355

 gcc gcc ggc ctc cac gcc gcg cct atg gcc gcc gag cgc gcc gtg gct     1161
 Ala Ala Gly Leu His Ala Ala Pro Met Ala Ala Glu Arg Ala Val Ala
                 360                 365                 370

 ttc atg gac cag gtg cgc gcc ttc cag gag cag gtg gac aag ctg ggc     1209
 Phe Met Asp Gln Val Arg Ala Phe Gln Glu Gln Val Asp Lys Leu Gly
             375                 380                 385

 cgc ctg cag gtc gac tcg gcc gag tat ggc tgc ctc aag gcc atc gcg     1257
 Arg Leu Gln Val Asp Ser Ala Glu Tyr Gly Cys Leu Lys Ala Ile Ala
         390                 395                 400

 ctc ttc acg ccc gac gcc tgt ggc ctc tca gac ccg gcc cac gtt gag     1305
 Leu Phe Thr Pro Asp Ala Cys Gly Leu Ser Asp Pro Ala His Val Glu
     405                 410                 415

 agc ctg cag gag aag gcg cag gtg gcc ctc acc gag tat gtg cgg gcg     1353
 Ser Leu Gln Glu Lys Ala Gln Val Ala Leu Thr Glu Tyr Val Arg Ala
 420                 425                 430                 435

 cag tac ccg tcc cag ccc cag cgc ttc ggg cgc ctg ctg ctg cgg ctc     1401
 Gln Tyr Pro Ser Gln Pro Gln Arg Phe Gly Arg Leu Leu Leu Arg Leu
                 440                 445                 450

 ccc gcc ctg cgc gcg gtc cct gcc tcc ctc atc tcc cag ctg ttc ttc     1449
 Pro Ala Leu Arg Ala Val Pro Ala Ser Leu Ile Ser Gln Leu Phe Phe
             455                 460                 465

 atg cgc ctg gtg ggg aag acg ccc att gag aca ctg atc aga gac atg     1497
 Met Arg Leu Val Gly Lys Thr Pro Ile Glu Thr Leu Ile Arg Asp Met
         470                 475                 480

 ctg ctg tcg ggg agt acc ttc aac tgg ccc tac ggc tcg ggc cag tga     1545
 Leu Leu Ser Gly Ser Thr Phe Asn Trp Pro Tyr Gly Ser Gly Gln 
     485                 490                 495

 ccatgacggg gccacgtgtg ctgtggccag gcctgcagac agacctcaag ggacagggaa   1605

 tgctgaggcc tcgaggggcc tcccggggcc caggactctg gcttctctcc tcagacttct   1665

 attttttaaa gactgtgaaa tgtttgtctt ttctgttttt taaatgatca tgaaaccaaa   1725

 aagagactga tcatccaggc ctcagcctca tcctccccag gacccctgtc caggatggag   1785

 ggtccaatcc taggacagcc ttgttcctca gcacccctag catgaacttg tgggatggtg   1845

 gggttggctt ccctggcatg atggacaaag gcctggcgtc ggccagaggg gctgctccag   1905

 tgggcagggg tagctagcgt gtgccaggca gatcctctgg acacgtaacc tatgtcagac   1965

 actacatgat gactcaaggc caataataaa gacatttcct acctgaaaaa aaaaaaaaaa   2025

 aac                                                                 2028




      <210> 245
      <211> 743
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (191)..(709)

      <400> 245
 cgtggcgaga agggccgcga gatgtgatcg gcccaaaact gctgcagcgt ctgccacagg     60

 cggctggcat ggctcgtagc cgagcactcg aaggttgcca gggcgtggac cttgtagggc    120

 acgcaggtgc tcgaagggga gcctcgggag cgctggcgac tcgtgctgcg ctcttgtctc    180

 gggagcccgg   atg tcc aga atg atg aag gcg agc cag ggg gcg ctg ctg     229
              Met Ser Arg Met Met Lys Ala Ser Gln Gly Ala Leu Leu
                1               5                  10

 gga gac aag agt ccg gaa ttt tcc aag aag tgc tct gaa agg tgg aag      277
 Gly Asp Lys Ser Pro Glu Phe Ser Lys Lys Cys Ser Glu Arg Trp Lys
      15                  20                  25

 aca atg tcc ggg aaa gag aag tct aaa ttt gat gaa atg gca aag acg      325
 Thr Met Ser Gly Lys Glu Lys Ser Lys Phe Asp Glu Met Ala Lys Thr
  30                  35                  40                  45

 gat aaa gtg cac tgt gat cgg gaa atg aag gga cca gct aag gga ggc      373
 Asp Lys Val His Cys Asp Arg Glu Met Lys Gly Pro Ala Lys Gly Gly
                  50                  55                  60

 aag aag aag aag gat cct agt gcc ccc aaa agg cca cca tct gga ttc      421
 Lys Lys Lys Lys Asp Pro Ser Ala Pro Lys Arg Pro Pro Ser Gly Phe
              65                  70                  75

 ttc ctg ttc tct tcg gaa atc cgc ccc aag atc aaa tcc aca aac cct      469
 Phe Leu Phe Ser Ser Glu Ile Arg Pro Lys Ile Lys Ser Thr Asn Pro
          80                  85                  90

 ggc atc tct att gga gat gtg gca aaa aag ctg ggt gag atg tgg aat      517
 Gly Ile Ser Ile Gly Asp Val Ala Lys Lys Leu Gly Glu Met Trp Asn
      95                 100                 105

 aac tta aat gac agt gaa aag cag cct tac atc act aag acg gca aag      565
 Asn Leu Asn Asp Ser Glu Lys Gln Pro Tyr Ile Thr Lys Thr Ala Lys
 110                 115                 120                 125

 ctg aag gag aag tac gag aag gat gtt gct gat tct aag tcg aaa ggg      613
 Leu Lys Glu Lys Tyr Glu Lys Asp Val Ala Asp Ser Lys Ser Lys Gly
                 130                 135                 140

 aag ttt gat ggc tca aag cgt cct gct aaa gtt gcc tgg aaa aag gtg      661
 Lys Phe Asp Gly Ser Lys Arg Pro Ala Lys Val Ala Trp Lys Lys Val
             145                 150                 155

 gaa gag gaa gat gaa gac gag gag gag gat gag gag gag gat gaa taa      709
 Glu Glu Glu Asp Glu Asp Glu Glu Glu Asp Glu Glu Glu Asp Glu 
         160                 165                 170

 acaaagtgtt tatctgtcaa aaaaaaaaaa gtaa                                743




      <210> 246
      <211> 6450
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (248)..(5377)

      <400> 246
 ccagtcagaa agcagtgctt taacaaatca acagccacaa aataacggag aggtgcagaa     60

 cagcaaaaac cagtcagata taaaccacag tacttcagga tcccattatg aaaattccca    120

 gcggggacct gtgtcttcta caagtgattc tagcacaaac tgtaagaatg ctgttgtaag    180

 tgacttgtcg gaaaaagaag catggccctc agcccctggc agtgatccgg agttggcttc    240

 agaatgt  atg gat gct gat tct gcc tcc agt tct gaa tca gag aga aac     289
          Met Asp Ala Asp Ser Ala Ser Ser Ser Glu Ser Glu Arg Asn
            1               5                  10

 atc act atc atg gct tca ggg aac aca ggt ggt gaa aaa gat ggc ctt      337
 Ile Thr Ile Met Ala Ser Gly Asn Thr Gly Gly Glu Lys Asp Gly Leu
  15                  20                  25                  30

 cgg aat agc act gga ctt ggt tcc caa aac aag ttt gta gtt ggt agc      385
 Arg Asn Ser Thr Gly Leu Gly Ser Gln Asn Lys Phe Val Val Gly Ser
                  35                  40                  45

 agc agc aat aat gtg ggc cat gga agt agt act ggg cca tgg ggt ttt      433
 Ser Ser Asn Asn Val Gly His Gly Ser Ser Thr Gly Pro Trp Gly Phe
              50                  55                  60

 tcc cat gga gcc ata ata agc aca tgt cag gtc tct gtg gat gct cct      481
 Ser His Gly Ala Ile Ile Ser Thr Cys Gln Val Ser Val Asp Ala Pro
          65                  70                  75

 gaa agc aaa tct gaa agt agc aac aat aga atg aat gct tgg ggc act      529
 Glu Ser Lys Ser Glu Ser Ser Asn Asn Arg Met Asn Ala Trp Gly Thr
      80                  85                  90

 gta agt tct tca tca aat gga ggg tta aat cca agc act ttg aat tca      577
 Val Ser Ser Ser Ser Asn Gly Gly Leu Asn Pro Ser Thr Leu Asn Ser
  95                 100                 105                 110

 gct agc aac cat ggt gcc tgg cca gta tta gag aac aat gga ctt gcc      625
 Ala Ser Asn His Gly Ala Trp Pro Val Leu Glu Asn Asn Gly Leu Ala
                 115                 120                 125

 cta aaa ggg cct gta ggg agt ggt agt tct ggc att aat att cag tgc      673
 Leu Lys Gly Pro Val Gly Ser Gly Ser Ser Gly Ile Asn Ile Gln Cys
             130                 135                 140

 agt act ata ggc cag atg cct aac aat cag agt att aac tct aaa gtg      721
 Ser Thr Ile Gly Gln Met Pro Asn Asn Gln Ser Ile Asn Ser Lys Val
         145                 150                 155

 agt ggt ggt tct acc cat ggt acc tgg gga agc ctt cag gaa act tgt      769
 Ser Gly Gly Ser Thr His Gly Thr Trp Gly Ser Leu Gln Glu Thr Cys
     160                 165                 170

 gaa tct gaa gta agt ggt aca cag aag gtt tca ttc agt ggt caa cct      817
 Glu Ser Glu Val Ser Gly Thr Gln Lys Val Ser Phe Ser Gly Gln Pro
 175                 180                 185                 190

 caa aat att acc act gaa atg act gga cca aat aac act act aac ttt      865
 Gln Asn Ile Thr Thr Glu Met Thr Gly Pro Asn Asn Thr Thr Asn Phe
                 195                 200                 205

 atg acc tct agt tta cca aac tcc ggt tca gtg cag aat aat gag ctg      913
 Met Thr Ser Ser Leu Pro Asn Ser Gly Ser Val Gln Asn Asn Glu Leu
             210                 215                 220

 cct agt agt aac aca ggg gcc tgg cgt gtg agc aca atg aat cat cct      961
 Pro Ser Ser Asn Thr Gly Ala Trp Arg Val Ser Thr Met Asn His Pro
         225                 230                 235

 cag atg cag gct cca tca ggt atg aat ggc act tcc ctt tct cac ctt     1009
 Gln Met Gln Ala Pro Ser Gly Met Asn Gly Thr Ser Leu Ser His Leu
     240                 245                 250

 agc aat gga gag tca aaa agt gga ggc tct tat ggt act aca tgg ggt     1057
 Ser Asn Gly Glu Ser Lys Ser Gly Gly Ser Tyr Gly Thr Thr Trp Gly
 255                 260                 265                 270

 gcc tat ggt tct aat tac tct gga gac aaa tgt tca ggc cct aat ggc     1105
 Ala Tyr Gly Ser Asn Tyr Ser Gly Asp Lys Cys Ser Gly Pro Asn Gly
                 275                 280                 285

 caa gct aat ggt gac act gtg aat gca act cta atg cag cct ggc gta     1153
 Gln Ala Asn Gly Asp Thr Val Asn Ala Thr Leu Met Gln Pro Gly Val
             290                 295                 300

 aat ggt cct atg ggc act aac ttt caa gtt aac aca aac aaa gga ggt     1201
 Asn Gly Pro Met Gly Thr Asn Phe Gln Val Asn Thr Asn Lys Gly Gly
         305                 310                 315

 ggt gtg tgg gaa tct ggt gca gca aac tcc cag agt aca tca tgg gga     1249
 Gly Val Trp Glu Ser Gly Ala Ala Asn Ser Gln Ser Thr Ser Trp Gly
     320                 325                 330

 agt gga aat ggc gca aat tct gga gga agt cga aga gga tgg gga acc     1297
 Ser Gly Asn Gly Ala Asn Ser Gly Gly Ser Arg Arg Gly Trp Gly Thr
 335                 340                 345                 350

 cct gca caa aac act ggc act aat tta ccc agc gtt gag tgg aac aaa     1345
 Pro Ala Gln Asn Thr Gly Thr Asn Leu Pro Ser Val Glu Trp Asn Lys
                 355                 360                 365

 ctg cct agc aat cag cat tcc aat gat agt gca aat ggc aat ggt aag     1393
 Leu Pro Ser Asn Gln His Ser Asn Asp Ser Ala Asn Gly Asn Gly Lys
             370                 375                 380

 acg ttt aca aat gga tgg aaa tct act gag gaa gag gat cag ggt tct     1441
 Thr Phe Thr Asn Gly Trp Lys Ser Thr Glu Glu Glu Asp Gln Gly Ser
         385                 390                 395

 gcc aca tct cag aca aat gag caa agc agt gtg tgg gcc aaa aca gga     1489
 Ala Thr Ser Gln Thr Asn Glu Gln Ser Ser Val Trp Ala Lys Thr Gly
     400                 405                 410

 ggt aca gtg gag agc gat ggt agt aca gaa agc act gga cgc ctt gag     1537
 Gly Thr Val Glu Ser Asp Gly Ser Thr Glu Ser Thr Gly Arg Leu Glu
 415                 420                 425                 430

 gaa aaa gga act ggg gaa agt cag agt aga gac aga aga aaa att gat     1585
 Glu Lys Gly Thr Gly Glu Ser Gln Ser Arg Asp Arg Arg Lys Ile Asp
                 435                 440                 445

 cag cac aca tta ctc caa agc att gta aac aga act gac tta gat cca     1633
 Gln His Thr Leu Leu Gln Ser Ile Val Asn Arg Thr Asp Leu Asp Pro
             450                 455                 460

 cgt gtc ctg tcc aac tct ggt tgg gga cag act cct att aag cag aat     1681
 Arg Val Leu Ser Asn Ser Gly Trp Gly Gln Thr Pro Ile Lys Gln Asn
         465                 470                 475

 act gcc tgg gat aca gaa aca tca cct aga ggg gaa cga aag act gac     1729
 Thr Ala Trp Asp Thr Glu Thr Ser Pro Arg Gly Glu Arg Lys Thr Asp
     480                 485                 490

 aat ggg aca gag gcc tgg gga agc tct gca aca cag act ttt aac tca     1777
 Asn Gly Thr Glu Ala Trp Gly Ser Ser Ala Thr Gln Thr Phe Asn Ser
 495                 500                 505                 510

 ggg gca tgt ata gat aag act agc cct aat ggt aat gat acc tca tct     1825
 Gly Ala Cys Ile Asp Lys Thr Ser Pro Asn Gly Asn Asp Thr Ser Ser
                 515                 520                 525

 gta tca ggg tgg ggc gat ccc aaa cct gct ctg agg tgg gga gat tcc     1873
 Val Ser Gly Trp Gly Asp Pro Lys Pro Ala Leu Arg Trp Gly Asp Ser
             530                 535                 540

 aaa ggc tca aac tgc cag ggg ggg tgg gaa gat gat tct gct gct aca     1921
 Lys Gly Ser Asn Cys Gln Gly Gly Trp Glu Asp Asp Ser Ala Ala Thr
         545                 550                 555

 gga atg gtc aag agc aat cag tgg ggg aat tgc aaa gag gag aag gct     1969
 Gly Met Val Lys Ser Asn Gln Trp Gly Asn Cys Lys Glu Glu Lys Ala
     560                 565                 570

 gca tgg aat gac tcg caa aag aat aaa cag gga tgg ggt gat gga caa     2017
 Ala Trp Asn Asp Ser Gln Lys Asn Lys Gln Gly Trp Gly Asp Gly Gln
 575                 580                 585                 590

 aaa tca agc caa ggg tgg tct gtt tct gcc agt gat aac tgg gga gaa     2065
 Lys Ser Ser Gln Gly Trp Ser Val Ser Ala Ser Asp Asn Trp Gly Glu
                 595                 600                 605

 act tca agg aat aac cat tgg ggt gag gcc aat aag aaa tcc agc tca     2113
 Thr Ser Arg Asn Asn His Trp Gly Glu Ala Asn Lys Lys Ser Ser Ser
             610                 615                 620

 gga ggt agt gac agt gac agg tcc gtt tcc ggt tgg aac gaa ctt ggt     2161
 Gly Gly Ser Asp Ser Asp Arg Ser Val Ser Gly Trp Asn Glu Leu Gly
         625                 630                 635

 aaa act agt tct ttc act tgg gga aac aac ata aat cca aat aat tca     2209
 Lys Thr Ser Ser Phe Thr Trp Gly Asn Asn Ile Asn Pro Asn Asn Ser
     640                 645                 650

 tca gga tgg gat gaa tct tct aaa cct act cct tcc cag gga tgg gga     2257
 Ser Gly Trp Asp Glu Ser Ser Lys Pro Thr Pro Ser Gln Gly Trp Gly
 655                 660                 665                 670

 gac cct cca aag tct aat cag tct cta ggt tgg gga gat tcg tca aag     2305
 Asp Pro Pro Lys Ser Asn Gln Ser Leu Gly Trp Gly Asp Ser Ser Lys
                 675                 680                 685

 cca gtc agc tct cca gac tgg aac aag caa caa gac att gtt gga tct     2353
 Pro Val Ser Ser Pro Asp Trp Asn Lys Gln Gln Asp Ile Val Gly Ser
             690                 695                 700

 tgg gga atc cca cca gct aca ggc aaa cct cct ggt aca ggc tgg ctg     2401
 Trp Gly Ile Pro Pro Ala Thr Gly Lys Pro Pro Gly Thr Gly Trp Leu
         705                 710                 715

 ggg gga cct ata cca gcc cca gca aaa gaa gaa gaa ccc aca ggc tgg     2449
 Gly Gly Pro Ile Pro Ala Pro Ala Lys Glu Glu Glu Pro Thr Gly Trp
     720                 725                 730

 gag gaa cca tcc cca gaa tct ata cgt cgc aaa atg gag att gat gat     2497
 Glu Glu Pro Ser Pro Glu Ser Ile Arg Arg Lys Met Glu Ile Asp Asp
 735                 740                 745                 750

 gga act tca gct tgg gga gat cca agc aaa tac aac tac aaa aat gtg     2545
 Gly Thr Ser Ala Trp Gly Asp Pro Ser Lys Tyr Asn Tyr Lys Asn Val
                 755                 760                 765

 aac atg tgg aac aaa aac gtc cca aat ggc aac agc cgt tca gac cag     2593
 Asn Met Trp Asn Lys Asn Val Pro Asn Gly Asn Ser Arg Ser Asp Gln
             770                 775                 780

 caa gca cag gta cat cag ctg cta acg cct gca agt gcc atc tca aac     2641
 Gln Ala Gln Val His Gln Leu Leu Thr Pro Ala Ser Ala Ile Ser Asn
         785                 790                 795

 aaa gag gca agc agt ggc tct ggc tgg ggt gag ccc tgg ggg gag cct     2689
 Lys Glu Ala Ser Ser Gly Ser Gly Trp Gly Glu Pro Trp Gly Glu Pro
     800                 805                 810

 tct act cca gcc aca act gtg gat aat ggt act tca gca tgg ggt aag     2737
 Ser Thr Pro Ala Thr Thr Val Asp Asn Gly Thr Ser Ala Trp Gly Lys
 815                 820                 825                 830

 ccc ata gac agt ggt ccc agc tgg ggg gaa ccc att gct gcg gca tcc     2785
 Pro Ile Asp Ser Gly Pro Ser Trp Gly Glu Pro Ile Ala Ala Ala Ser
                 835                 840                 845

 agc aca tcc acg tgg ggc tcc agc tct gtt ggt cca caa gca tta agc     2833
 Ser Thr Ser Thr Trp Gly Ser Ser Ser Val Gly Pro Gln Ala Leu Ser
             850                 855                 860

 aaa tct ggg cca aaa tct atg caa gat ggc tgg tgt ggt gat gat atg     2881
 Lys Ser Gly Pro Lys Ser Met Gln Asp Gly Trp Cys Gly Asp Asp Met
         865                 870                 875

 cca ttg cct gga aat cgc ccc act ggc tgg gaa gag gaa gag gat gtg     2929
 Pro Leu Pro Gly Asn Arg Pro Thr Gly Trp Glu Glu Glu Glu Asp Val
     880                 885                 890

 gag att gga atg tgg aat agt aat tca tct caa gag ctt aac tca tct     2977
 Glu Ile Gly Met Trp Asn Ser Asn Ser Ser Gln Glu Leu Asn Ser Ser
 895                 900                 905                 910

 tta aat tgg cca cca tat aca aag aaa atg tca tcg aag ggt ctg agt     3025
 Leu Asn Trp Pro Pro Tyr Thr Lys Lys Met Ser Ser Lys Gly Leu Ser
                 915                 920                 925

 ggc aaa aaa agg aga agg gaa agg gga atg atg aaa ggt gga aac aaa     3073
 Gly Lys Lys Arg Arg Arg Glu Arg Gly Met Met Lys Gly Gly Asn Lys
             930                 935                 940

 caa gaa gaa gcg tgg ata aat cca ttt gtt aaa cag ttt tca aac atc     3121
 Gln Glu Glu Ala Trp Ile Asn Pro Phe Val Lys Gln Phe Ser Asn Ile
         945                 950                 955

 agt ttt tcg aga gac tca cca gag gaa aat gta caa agc aat aag atg     3169
 Ser Phe Ser Arg Asp Ser Pro Glu Glu Asn Val Gln Ser Asn Lys Met
     960                 965                 970

 gac ctt tct gga gga atg tta caa gac aaa cga atg gag ata gat aaa     3217
 Asp Leu Ser Gly Gly Met Leu Gln Asp Lys Arg Met Glu Ile Asp Lys
 975                 980                 985                 990

 cat agc cta aat att ggt gat tac aat cga acg gtc ggg aaa ggc cct     3265
 His Ser Leu Asn Ile Gly Asp Tyr Asn Arg Thr Val Gly Lys Gly Pro
                 995                1000                1005

 ggt tct cgg cct cag att tcc aaa gag tct tcc atg gag cgc aat cct     3313
 Gly Ser Arg Pro Gln Ile Ser Lys Glu Ser Ser Met Glu Arg Asn Pro
            1010                1015                1020

 tat ttt gat aag gat ggc att gta gca gat gaa tcc caa aac atg cag     3361
 Tyr Phe Asp Lys Asp Gly Ile Val Ala Asp Glu Ser Gln Asn Met Gln
        1025                1030                1035

 ttt atg tcc agt caa agc atg aag ctt ccc cct tca aat agt gca cta     3409
 Phe Met Ser Ser Gln Ser Met Lys Leu Pro Pro Ser Asn Ser Ala Leu
    1040                1045                1050

 cct aac cag gcc ctt ggc tcc ata gca ggg ctg ggt atg caa aac ttg     3457
 Pro Asn Gln Ala Leu Gly Ser Ile Ala Gly Leu Gly Met Gln Asn Leu
1055                1060                1065                1070

 aat tct gtt aga cag aat ggc aat ccc agt atg ttt ggt gtt gga aac     3505
 Asn Ser Val Arg Gln Asn Gly Asn Pro Ser Met Phe Gly Val Gly Asn
                1075                1080                1085

 aca gca gca caa ccc cgg ggc atg cag cag cct cca gca caa cct ctt     3553
 Thr Ala Ala Gln Pro Arg Gly Met Gln Gln Pro Pro Ala Gln Pro Leu
            1090                1095                1100

 agt tca tct cag cct aat ctc cgt gct caa gtg cct cct cca tta ctc     3601
 Ser Ser Ser Gln Pro Asn Leu Arg Ala Gln Val Pro Pro Pro Leu Leu
        1105                1110                1115

 tcc cct cag gtt cca gtt tca ttg ctg aag tat gca cca aac aac ggt     3649
 Ser Pro Gln Val Pro Val Ser Leu Leu Lys Tyr Ala Pro Asn Asn Gly
    1120                1125                1130

 ggc ctg aat cca ctc ttt ggc cct caa cag gta gcc atg ctg aac cag     3697
 Gly Leu Asn Pro Leu Phe Gly Pro Gln Gln Val Ala Met Leu Asn Gln
1135                1140                1145                1150

 cta tcc cag cta aac cag ctt tct cag atc tcc cag tta cag cga ttg     3745
 Leu Ser Gln Leu Asn Gln Leu Ser Gln Ile Ser Gln Leu Gln Arg Leu
                1155                1160                1165

 tta gcg cag cag caa agg gcg cag agt cag aga agc gtg cct tct ggg     3793
 Leu Ala Gln Gln Gln Arg Ala Gln Ser Gln Arg Ser Val Pro Ser Gly
            1170                1175                1180

 aac cgg ccg cag caa gac cag cag ggt cga cct ctt agt gtg cag cag     3841
 Asn Arg Pro Gln Gln Asp Gln Gln Gly Arg Pro Leu Ser Val Gln Gln
        1185                1190                1195

 caa atg atg caa caa tct cgt caa ctt gat cca aac ctg ttg gtg aag     3889
 Gln Met Met Gln Gln Ser Arg Gln Leu Asp Pro Asn Leu Leu Val Lys
    1200                1205                1210

 cag cag act cca cca tct cag cag cag cca ctc cat cag cca gcc atg     3937
 Gln Gln Thr Pro Pro Ser Gln Gln Gln Pro Leu His Gln Pro Ala Met
1215                1220                1225                1230

 aag tct ttc ctt gac aat gtc atg ccc cac act aca cct gag ctg caa     3985
 Lys Ser Phe Leu Asp Asn Val Met Pro His Thr Thr Pro Glu Leu Gln
                1235                1240                1245

 aaa ggg cca tca cca ata aat gct ttc agc aac ttc cct ata ggc ttg     4033
 Lys Gly Pro Ser Pro Ile Asn Ala Phe Ser Asn Phe Pro Ile Gly Leu
            1250                1255                1260

 aac tca aac ttg aat gta aat atg gat atg aac agt att aaa gag cca     4081
 Asn Ser Asn Leu Asn Val Asn Met Asp Met Asn Ser Ile Lys Glu Pro
        1265                1270                1275

 cag tca aga cta agg aag tgg acg aca gtg gac agc att tct gtg aac     4129
 Gln Ser Arg Leu Arg Lys Trp Thr Thr Val Asp Ser Ile Ser Val Asn
    1280                1285                1290

 aca tct ttg gat caa aac tcc agc aaa cat ggt gct att tca agt ggt     4177
 Thr Ser Leu Asp Gln Asn Ser Ser Lys His Gly Ala Ile Ser Ser Gly
1295                1300                1305                1310

 ttc agg ctg gaa gag tct cca ttt gtt ccc tat gac ttt atg aac agc     4225
 Phe Arg Leu Glu Glu Ser Pro Phe Val Pro Tyr Asp Phe Met Asn Ser
                1315                1320                1325

 agt act tca cca gcc agt cct cca ggt tca ata gga gat ggc tgg cca     4273
 Ser Thr Ser Pro Ala Ser Pro Pro Gly Ser Ile Gly Asp Gly Trp Pro
            1330                1335                1340

 cgt gcc aaa tcg cct aac ggc tct agc agt gtt aat tgg cca cca gaa     4321
 Arg Ala Lys Ser Pro Asn Gly Ser Ser Ser Val Asn Trp Pro Pro Glu
        1345                1350                1355

 ttt cgt cct ggt gag cca tgg aaa ggt tat cca aac att gac cct gaa     4369
 Phe Arg Pro Gly Glu Pro Trp Lys Gly Tyr Pro Asn Ile Asp Pro Glu
    1360                1365                1370

 act gac cct tac gtc act cct ggc agt gtc ata aac aat ctt tca att     4417
 Thr Asp Pro Tyr Val Thr Pro Gly Ser Val Ile Asn Asn Leu Ser Ile
1375                1380                1385                1390

 aat act gtg cgg gaa gtt gac cac ctc agg gac agg aac agt ggg tca     4465
 Asn Thr Val Arg Glu Val Asp His Leu Arg Asp Arg Asn Ser Gly Ser
                1395                1400                1405

 tcc tca tcc ttg aac acc acg ctg cct tca act agt gcc tgg tca tcc     4513
 Ser Ser Ser Leu Asn Thr Thr Leu Pro Ser Thr Ser Ala Trp Ser Ser
            1410                1415                1420

 att cgt gcc tcc aac tac aac gtt ccc ctc agc agt aca gca caa agc     4561
 Ile Arg Ala Ser Asn Tyr Asn Val Pro Leu Ser Ser Thr Ala Gln Ser
        1425                1430                1435

 act tca gcc aga aat agt gat tcc aaa ttg aca tgg tct cct ggt tca     4609
 Thr Ser Ala Arg Asn Ser Asp Ser Lys Leu Thr Trp Ser Pro Gly Ser
    1440                1445                1450

 gtt aca aac acc tct ctg gct cat gag ctg tgg aag gtc cct ttg cca     4657
 Val Thr Asn Thr Ser Leu Ala His Glu Leu Trp Lys Val Pro Leu Pro
1455                1460                1465                1470

 cct aaa aac atc act gct ccg tcc cgc cca cct ccg gga ctg act ggt     4705
 Pro Lys Asn Ile Thr Ala Pro Ser Arg Pro Pro Pro Gly Leu Thr Gly
                1475                1480                1485

 cag aag cca ccc ttg tct acg tgg gat aat tct ccc ctt cgt ata ggt     4753
 Gln Lys Pro Pro Leu Ser Thr Trp Asp Asn Ser Pro Leu Arg Ile Gly
            1490                1495                1500

 gga gga tgg gga aat tct gac gcc aga tat acc cca ggt tcc agc tgg     4801
 Gly Gly Trp Gly Asn Ser Asp Ala Arg Tyr Thr Pro Gly Ser Ser Trp
        1505                1510                1515

 ggt gag agc agc tca ggg aga ata aca aat tgg ctt gtt cta aaa aac     4849
 Gly Glu Ser Ser Ser Gly Arg Ile Thr Asn Trp Leu Val Leu Lys Asn
    1520                1525                1530

 ctt aca cct cag atc gat ggc tca act ctg cgc act ctg tgc atg cag     4897
 Leu Thr Pro Gln Ile Asp Gly Ser Thr Leu Arg Thr Leu Cys Met Gln
1535                1540                1545                1550

 cac ggc ccg ctg atc aca ttc cac ctg aac ctc cct cac gga aat gct     4945
 His Gly Pro Leu Ile Thr Phe His Leu Asn Leu Pro His Gly Asn Ala
                1555                1560                1565

 ctg gtc cgc tac agt tca aaa gaa gag gta gtg aag gca caa aag tct     4993
 Leu Val Arg Tyr Ser Ser Lys Glu Glu Val Val Lys Ala Gln Lys Ser
            1570                1575                1580

 ctg cac atg tgt gta ctg ggg aac act act att ctt gct gag ttt gcc     5041
 Leu His Met Cys Val Leu Gly Asn Thr Thr Ile Leu Ala Glu Phe Ala
        1585                1590                1595

 agt gaa gag gag atc agt cgt ttc ttt gca caa agc cag tct ctg acc     5089
 Ser Glu Glu Glu Ile Ser Arg Phe Phe Ala Gln Ser Gln Ser Leu Thr
    1600                1605                1610

 cct tct ccc ggc tgg cag tct ctc ggg tcc agc cag agc cgg ctg ggc     5137
 Pro Ser Pro Gly Trp Gln Ser Leu Gly Ser Ser Gln Ser Arg Leu Gly
1615                1620                1625                1630

 tcc ctc gac tgt tcc cac tca ttc tcc agc cgg acc gat ctc aat cac     5185
 Ser Leu Asp Cys Ser His Ser Phe Ser Ser Arg Thr Asp Leu Asn His
                1635                1640                1645

 tgg aat ggt gct ggg ctg tcg gga act aac tgt gga gac ctt cac ggc     5233
 Trp Asn Gly Ala Gly Leu Ser Gly Thr Asn Cys Gly Asp Leu His Gly
            1650                1655                1660

 act tca ctc tgg ggg acc ccg cat tat tcc aca agc ctg tgg ggt ccc     5281
 Thr Ser Leu Trp Gly Thr Pro His Tyr Ser Thr Ser Leu Trp Gly Pro
        1665                1670                1675

 cca agc agc agc gac ccc cga gga att agc agc cca tct ccc att aac     5329
 Pro Ser Ser Ser Asp Pro Arg Gly Ile Ser Ser Pro Ser Pro Ile Asn
    1680                1685                1690

 gct ttt ctt tct gtt gac cac ctg ggt ggg ggt gga gag tcc atg taa     5377
 Ala Phe Leu Ser Val Asp His Leu Gly Gly Gly Gly Glu Ser Met 
1695                1700                1705

 cagtgtagat gcagactcac cgaccgggac ctcagacgcg agggaaagga gcactaagtg   5437

 gggctcgccg cctgcagcca ggggccgcct gtgggaacag ctattctctg catttgaata   5497

 ggctttccat tttgttttgg aggttctcac tttgaacctt cttgtttaca gatttttttg   5557

 tttgtttttt gagaaaaaaa aatgtttact cttccatcat ttaaaaaaaa tgtaaaagac   5617

 aaaaaaaaaa tggaggatga tttaaaagat gctttctatc tctgggaaaa aggagcagca   5677

 tttggccatg ttcttttgtt tttctattcc tgtcccaaat caaagagcat ggttctcagg   5737

 aaaaccagtt ccccagttta aaaaaaaaaa aaaaaaaaat tccttgtagt ttcttagagg   5797

 aaaaaaagaa aaaccccaac ttttagcact gatactacat attgctctgt taaagaattt   5857

 tctctgccaa aaaaaaaaga aaaaacaaaa aaacgcttaa agctggagtt tgacattctg   5917

 ctttcagatg ctgtcttttt attagtgagt gatgatggtt tgctaataat caataggtaa   5977

 taattttttg taatcccatc aagtggctcc atatgtttct gctctctcgt gactgtgtta   6037

 atgtttaact gttgtacctt aaagccgaaa tcagtaacta tgcatactgt aaccaaggta   6097

 ttgggcttac agagttgttt gttgtataaa gaaaatttta aatgttgttg caaactaacg   6157

 agttacacca ttttaaactt tctttcctcc cccctttttt tgcccacaaa tggtattata   6217

 atgcttgctt agtcaaagaa gagagactaa acaagggtaa aaattttaac agtacagaat   6277

 ttgccatcat atcattgcct tgattctaac tgtttgtgtc ctaagatgca aaagaagtca   6337

 gtggctttta actgtttaca aatagaatgt gattgtaaaa tgtacagttt ggttgtgttt   6397

 gaattatgaa atttcttcag atataataaa ccatgacttt ttggctgctc aac          6450




      <210> 247
      <211> 2930
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (31)..(2208)

      <400> 247
 atcttttttt tttttttttt tacaaaggga     atg atg aaa ggt gga aac aaa      51
                                      Met Met Lys Gly Gly Asn Lys
                                        1               5

 caa gaa gaa gcg tgg ata aat cca ttt gtt aaa cag ttt tca aac atc       99
 Gln Glu Glu Ala Trp Ile Asn Pro Phe Val Lys Gln Phe Ser Asn Ile
          10                  15                  20

 agt ttt tcg aga gac tca cca gag gaa aat gta caa agc aat aag atg      147
 Ser Phe Ser Arg Asp Ser Pro Glu Glu Asn Val Gln Ser Asn Lys Met
      25                  30                  35

 gac ctt tct gga gga atg tta caa gac aaa cga atg gag ata gat aaa      195
 Asp Leu Ser Gly Gly Met Leu Gln Asp Lys Arg Met Glu Ile Asp Lys
  40                  45                  50                  55

 cat agc cta aat att ggt gat tac aat cga acg gtc ggg aaa ggc cct      243
 His Ser Leu Asn Ile Gly Asp Tyr Asn Arg Thr Val Gly Lys Gly Pro
                  60                  65                  70

 ggt tct cgg cct cag att tcc aaa gag tct tcc atg gag cgc aat cct      291
 Gly Ser Arg Pro Gln Ile Ser Lys Glu Ser Ser Met Glu Arg Asn Pro
              75                  80                  85

 tat ttt gat aag aat ggc aat ccc agt atg ttt ggt gtt gga aac aca      339
 Tyr Phe Asp Lys Asn Gly Asn Pro Ser Met Phe Gly Val Gly Asn Thr
          90                  95                 100

 gca gca caa ccc cgg ggc atg cag cag cct cca gca caa cct ctt agt      387
 Ala Ala Gln Pro Arg Gly Met Gln Gln Pro Pro Ala Gln Pro Leu Ser
     105                 110                 115

 tca tct cag cct aat ctc cgt gct caa gtg cct cct cca tta ctc tcc      435
 Ser Ser Gln Pro Asn Leu Arg Ala Gln Val Pro Pro Pro Leu Leu Ser
 120                 125                 130                 135

 cct cag gtt cca gtt tca ttg ctg aag tat gca cca aac aac ggt ggc      483
 Pro Gln Val Pro Val Ser Leu Leu Lys Tyr Ala Pro Asn Asn Gly Gly
                 140                 145                 150

 ctg aat cca ctc ttt ggc cct caa cag gta gcc atg ctg aac cag cta      531
 Leu Asn Pro Leu Phe Gly Pro Gln Gln Val Ala Met Leu Asn Gln Leu
             155                 160                 165

 tcc cag cta aac cag ctt tct cag atc tcc cag tta cag cga ttg tta      579
 Ser Gln Leu Asn Gln Leu Ser Gln Ile Ser Gln Leu Gln Arg Leu Leu
         170                 175                 180

 gcg cag cag caa agg gcg cag agt cag aga agc gtg cct tct ggg aac      627
 Ala Gln Gln Gln Arg Ala Gln Ser Gln Arg Ser Val Pro Ser Gly Asn
     185                 190                 195

 cgg ccg cag caa gac cag cag ggt cga cct ctt agt gtg cag cag caa      675
 Arg Pro Gln Gln Asp Gln Gln Gly Arg Pro Leu Ser Val Gln Gln Gln
 200                 205                 210                 215

 atg atg caa caa tct cgt caa ctt gat cca aac ctg ttg gtg aag cag      723
 Met Met Gln Gln Ser Arg Gln Leu Asp Pro Asn Leu Leu Val Lys Gln
                 220                 225                 230

 cag act cca cca tct cag cag cag cca ctc cat cag cca gcc atg aag      771
 Gln Thr Pro Pro Ser Gln Gln Gln Pro Leu His Gln Pro Ala Met Lys
             235                 240                 245

 tct ttc ctt gac aat gtc atg ccc cac act aca cct gag ctg caa aaa      819
 Ser Phe Leu Asp Asn Val Met Pro His Thr Thr Pro Glu Leu Gln Lys
         250                 255                 260

 ggg cca tca cca ata aat gct ttc agc aac ttc cct ata ggc ttg aac      867
 Gly Pro Ser Pro Ile Asn Ala Phe Ser Asn Phe Pro Ile Gly Leu Asn
     265                 270                 275

 tca aac ttg aat gta aat atg gat atg aac agt att aaa gag cca cag      915
 Ser Asn Leu Asn Val Asn Met Asp Met Asn Ser Ile Lys Glu Pro Gln
 280                 285                 290                 295

 tca aga cta agg aag tgg acg aca gtg gac agc att tct gtg aac aca      963
 Ser Arg Leu Arg Lys Trp Thr Thr Val Asp Ser Ile Ser Val Asn Thr
                 300                 305                 310

 tct ttg gat caa aac tcc agc aaa cat ggt gct att tca agt ggt ttc     1011
 Ser Leu Asp Gln Asn Ser Ser Lys His Gly Ala Ile Ser Ser Gly Phe
             315                 320                 325

 agg ctg gaa gag tct cca ttt gtt ccc tat gac ttt atg aac agc agt     1059
 Arg Leu Glu Glu Ser Pro Phe Val Pro Tyr Asp Phe Met Asn Ser Ser
         330                 335                 340

 act tca cca gcc agt cct cca ggt tca ata gga gat ggc tgg cca cgt     1107
 Thr Ser Pro Ala Ser Pro Pro Gly Ser Ile Gly Asp Gly Trp Pro Arg
     345                 350                 355

 gcc aaa tcg cct aac ggc tct agc agt gtt aat tgg cca cca gaa ttt     1155
 Ala Lys Ser Pro Asn Gly Ser Ser Ser Val Asn Trp Pro Pro Glu Phe
 360                 365                 370                 375

 cgt cct ggt gag cca tgg aaa ggt tat cca aac att gac cct gaa act     1203
 Arg Pro Gly Glu Pro Trp Lys Gly Tyr Pro Asn Ile Asp Pro Glu Thr
                 380                 385                 390

 gac cct tac gtc act cct ggc agt gtc ata aac aat ctt tca att aat     1251
 Asp Pro Tyr Val Thr Pro Gly Ser Val Ile Asn Asn Leu Ser Ile Asn
             395                 400                 405

 act gtg cgg gaa gtt gac cac ctc agg gac agg aac agt ggg tca tcc     1299
 Thr Val Arg Glu Val Asp His Leu Arg Asp Arg Asn Ser Gly Ser Ser
         410                 415                 420

 tca tcc ttg aac acc acg ctg cct tca act agt gcc tgg tca tcc att     1347
 Ser Ser Leu Asn Thr Thr Leu Pro Ser Thr Ser Ala Trp Ser Ser Ile
     425                 430                 435

 cgt gcc tcc aac tac aac gtt ccc ctc agc agt aca gca caa agc act     1395
 Arg Ala Ser Asn Tyr Asn Val Pro Leu Ser Ser Thr Ala Gln Ser Thr
 440                 445                 450                 455

 tca gcc aga aat agt gat tcc aaa ttg aca tgg tct cct ggt tca gtt     1443
 Ser Ala Arg Asn Ser Asp Ser Lys Leu Thr Trp Ser Pro Gly Ser Val
                 460                 465                 470

 aca aac acc tct ctg gct cat gag ctg tgg aag gtc cct ttg cca cct     1491
 Thr Asn Thr Ser Leu Ala His Glu Leu Trp Lys Val Pro Leu Pro Pro
             475                 480                 485

 aaa aac atc act gct ccg tcc cgc cca cct ccg gga ctg act ggt cag     1539
 Lys Asn Ile Thr Ala Pro Ser Arg Pro Pro Pro Gly Leu Thr Gly Gln
         490                 495                 500

 aag cca ccc ttg tct acg tgg gat aat tct ccc ctt cgt ata ggt gga     1587
 Lys Pro Pro Leu Ser Thr Trp Asp Asn Ser Pro Leu Arg Ile Gly Gly
     505                 510                 515

 gga tgg gga aat tct gac gcc aga tat acc cca ggt tcc agc tgg ggt     1635
 Gly Trp Gly Asn Ser Asp Ala Arg Tyr Thr Pro Gly Ser Ser Trp Gly
 520                 525                 530                 535

 gag agc agc tca ggg aga ata aca aat tgg ctt gtt cta aaa aac ctt     1683
 Glu Ser Ser Ser Gly Arg Ile Thr Asn Trp Leu Val Leu Lys Asn Leu
                 540                 545                 550

 aca cct cag atc gat ggc tca act ctg cgc act ctg tgc atg cag cac     1731
 Thr Pro Gln Ile Asp Gly Ser Thr Leu Arg Thr Leu Cys Met Gln His
             555                 560                 565

 ggc ccg ctg atc aca ttc cac ctg aac ctc cct cac gga aat gct ctg     1779
 Gly Pro Leu Ile Thr Phe His Leu Asn Leu Pro His Gly Asn Ala Leu
         570                 575                 580

 gtc cgc tac agt tca aaa gaa gag gta gtg aag gca caa aag tct ctg     1827
 Val Arg Tyr Ser Ser Lys Glu Glu Val Val Lys Ala Gln Lys Ser Leu
     585                 590                 595

 cac atg tgt gta ctg ggg aac act act att ctt gct gag ttt gcc agt     1875
 His Met Cys Val Leu Gly Asn Thr Thr Ile Leu Ala Glu Phe Ala Ser
 600                 605                 610                 615

 gaa gag gag atc agt cgt ttc ttt gca caa agc cag tct ctg acc cct     1923
 Glu Glu Glu Ile Ser Arg Phe Phe Ala Gln Ser Gln Ser Leu Thr Pro
                 620                 625                 630

 tct ccc ggc tgg cag tct ctc ggg tcc agc cag agc cgg ctg ggc tcc     1971
 Ser Pro Gly Trp Gln Ser Leu Gly Ser Ser Gln Ser Arg Leu Gly Ser
             635                 640                 645

 ctc gac tgt tcc cac tca ttc tcc agc cgg acc gat ctc aat cac tgg     2019
 Leu Asp Cys Ser His Ser Phe Ser Ser Arg Thr Asp Leu Asn His Trp
         650                 655                 660

 aat ggt gct ggg ctg tcg gga act aac tgt gga gac ctt cac ggc act     2067
 Asn Gly Ala Gly Leu Ser Gly Thr Asn Cys Gly Asp Leu His Gly Thr
     665                 670                 675

 tca ctc tgg ggg acc ccg cat tat tcc aca agc ctg tgg ggt ccc cca     2115
 Ser Leu Trp Gly Thr Pro His Tyr Ser Thr Ser Leu Trp Gly Pro Pro
 680                 685                 690                 695

 agc agc agc gac ccc cga gga att agc agc cca tct ccc att aac gct     2163
 Ser Ser Ser Asp Pro Arg Gly Ile Ser Ser Pro Ser Pro Ile Asn Ala
                 700                 705                 710

 ttt ctt tct gtt gac cac ctg ggt ggg ggt gga gag tcc atg taa cag     2211
 Phe Leu Ser Val Asp His Leu Gly Gly Gly Gly Glu Ser Met 
             715                 720                 725

 tgtagatgca gactcaccga ccgggacctc agacgcgagg gaaaggagca ctaagtgggg   2271

 ctcgccgcct gcagccaggg gccgcctgtg ggaacagcta ttctctgcac tttgaatagg   2331

 ctttccattt tgttttggag gttctcactt tgaaccttct tgtttacaga tttttttgtt   2391

 tgttttttga gaaaaaaaaa tgtttactct tccatcattt aaaaaaaatg taaaagacaa   2451

 aaaaaaaatg gaggatgatt taaaagatgc tttctatctc tgggaaaaag gagcagcatt   2511

 tggccatgtt cttttgtttt tctattcctg tcccaaatca aagagcatgg ttctcaggaa   2571

 aaccagttcc ccagtttaaa aaaaaaaaaa aaaaaaattc cttgtagttt cttagaggaa   2631

 aaaaagaaaa accccaactt ttagcactga tactacatat tgctctgtta aagaattttc   2691

 tctgccaaaa aaaaaagaaa aaacaaaaaa acgcttaaag ctggagtttg acattctgct   2751

 ttcagatgct gtctttttat tagtgagtga tgatggtttg ctaataatca ataggtaata   2811

 attttttgta atcccatcaa gtggctccat atgtttctgc tctctcgtga ctgtgttaat   2871

 gtttaactgt tgtaccttaa agccgaaatc agtaactatg catactgtaa ccaaggtat    2930




      <210> 248
      <211> 3066
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (40)..(1992)

      <400> 248
 tttgataagg atggcattgt agcagatgaa tcccaaaac   atg cag ttt atg tcc      54
                                              Met Gln Phe Met Ser
                                                1               5

 agt caa agc atg aag ctt ccc cct tca aat agt gca cta cct aac cag      102
 Ser Gln Ser Met Lys Leu Pro Pro Ser Asn Ser Ala Leu Pro Asn Gln
                  10                  15                  20

 gcc ctt ggc tcc ata gca ggg ctg ggt atg caa aac ttg aat tct gtt      150
 Ala Leu Gly Ser Ile Ala Gly Leu Gly Met Gln Asn Leu Asn Ser Val
              25                  30                  35

 aga cag aat ggc aat ccc agt atg ttt ggt gtt gga aac aca gca gca      198
 Arg Gln Asn Gly Asn Pro Ser Met Phe Gly Val Gly Asn Thr Ala Ala
          40                  45                  50

 caa ccc cgg ggc atg cag cag cct cca gca caa cct ctt agt tca tct      246
 Gln Pro Arg Gly Met Gln Gln Pro Pro Ala Gln Pro Leu Ser Ser Ser
      55                  60                  65

 cag cct aat ctc cgt gct caa gtg cct cct cca tta ctc tcc cct cag      294
 Gln Pro Asn Leu Arg Ala Gln Val Pro Pro Pro Leu Leu Ser Pro Gln
  70                  75                  80                  85

 gta gcc atg ctg aac cag cta tcc cag cta aac cag ctt tct cag atc      342
 Val Ala Met Leu Asn Gln Leu Ser Gln Leu Asn Gln Leu Ser Gln Ile
                  90                  95                 100

 tcc cag tta cag cga ttg tta gcg cag cag caa agg gcg cag agt cag      390
 Ser Gln Leu Gln Arg Leu Leu Ala Gln Gln Gln Arg Ala Gln Ser Gln
             105                 110                 115

 aga agc gtg cct tct ggg aac cgg ccg cag caa gac cag cag ggt cga      438
 Arg Ser Val Pro Ser Gly Asn Arg Pro Gln Gln Asp Gln Gln Gly Arg
         120                 125                 130

 cct ctt agt gtg cag cag caa atg atg caa caa tct cgt caa ctt gat      486
 Pro Leu Ser Val Gln Gln Gln Met Met Gln Gln Ser Arg Gln Leu Asp
     135                 140                 145

 cca aac ctg ttg gtg aag cag cag act cca cca tct cag cag cag cca      534
 Pro Asn Leu Leu Val Lys Gln Gln Thr Pro Pro Ser Gln Gln Gln Pro
 150                 155                 160                 165

 ctc cat cag cca gcc atg aag tct ttc ctt gac aat gtc atg ccc cac      582
 Leu His Gln Pro Ala Met Lys Ser Phe Leu Asp Asn Val Met Pro His
                 170                 175                 180

 act aca cct gag ctg caa aaa ggg cca tca cca ata aat gct ttc agc      630
 Thr Thr Pro Glu Leu Gln Lys Gly Pro Ser Pro Ile Asn Ala Phe Ser
             185                 190                 195

 aac ttc cct ata ggc ttg aac tca aac ttg aat gta aat atg gat atg      678
 Asn Phe Pro Ile Gly Leu Asn Ser Asn Leu Asn Val Asn Met Asp Met
         200                 205                 210

 aac agt att aaa gag cca cag tca aga cta agg aag tgg acg aca gtg      726
 Asn Ser Ile Lys Glu Pro Gln Ser Arg Leu Arg Lys Trp Thr Thr Val
     215                 220                 225

 gac agc att tct gtg aac aca tct ttg gat caa aac tcc agc aaa cat      774
 Asp Ser Ile Ser Val Asn Thr Ser Leu Asp Gln Asn Ser Ser Lys His
 230                 235                 240                 245

 ggt gct att tca agt ggt ttc agg ctg gaa gag tct cca ttt gtt ccc      822
 Gly Ala Ile Ser Ser Gly Phe Arg Leu Glu Glu Ser Pro Phe Val Pro
                 250                 255                 260

 tat gac ttt atg aac agc agt act tca cca gcc agt cct cca ggt tca      870
 Tyr Asp Phe Met Asn Ser Ser Thr Ser Pro Ala Ser Pro Pro Gly Ser
             265                 270                 275

 ata gga gat ggc tgg cca cgt gcc aaa tcg cct aac ggc tct agc agt      918
 Ile Gly Asp Gly Trp Pro Arg Ala Lys Ser Pro Asn Gly Ser Ser Ser
         280                 285                 290

 gtt aat tgg cca cca gaa ttt cgt cct ggt gag cca tgg aaa ggt tat      966
 Val Asn Trp Pro Pro Glu Phe Arg Pro Gly Glu Pro Trp Lys Gly Tyr
     295                 300                 305

 cca aac att gac cct gaa act gac cct tac gtc act cct ggc agt gtc     1014
 Pro Asn Ile Asp Pro Glu Thr Asp Pro Tyr Val Thr Pro Gly Ser Val
 310                 315                 320                 325

 ata aac aat ctt tca att aat act gtg cgg gaa gtt gac cac ctc agg     1062
 Ile Asn Asn Leu Ser Ile Asn Thr Val Arg Glu Val Asp His Leu Arg
                 330                 335                 340

 gac agg aac agt ggg tca tcc tca tcc ttg aac acc acg ctg cct tca     1110
 Asp Arg Asn Ser Gly Ser Ser Ser Ser Leu Asn Thr Thr Leu Pro Ser
             345                 350                 355

 act agt gcc tgg tca tcc att cgt gcc tcc aac tac aac gtt ccc ctc     1158
 Thr Ser Ala Trp Ser Ser Ile Arg Ala Ser Asn Tyr Asn Val Pro Leu
         360                 365                 370

 agc agt aca gca caa agc act tca gcc aga aat agt gat tcc aaa ttg     1206
 Ser Ser Thr Ala Gln Ser Thr Ser Ala Arg Asn Ser Asp Ser Lys Leu
     375                 380                 385

 aca tgg tct cct ggt tca gtt aca aac acc tct ctg gct cat gag ctg     1254
 Thr Trp Ser Pro Gly Ser Val Thr Asn Thr Ser Leu Ala His Glu Leu
 390                 395                 400                 405

 tgg aag gtc cct ttg cca cct aaa aac atc act gct ccg tcc cgc cca     1302
 Trp Lys Val Pro Leu Pro Pro Lys Asn Ile Thr Ala Pro Ser Arg Pro
                 410                 415                 420

 cct ccg gga ctg act ggt cag aag cca ccc ttg tct acg tgg gat aat     1350
 Pro Pro Gly Leu Thr Gly Gln Lys Pro Pro Leu Ser Thr Trp Asp Asn
             425                 430                 435

 tct ccc ctt cgt ata ggt gga gga tgg gga aat tct gac gcc aga tat     1398
 Ser Pro Leu Arg Ile Gly Gly Gly Trp Gly Asn Ser Asp Ala Arg Tyr
         440                 445                 450

 acc cca ggt tcc agc tgg ggt gag agc agc tca ggg aga ata aca aat     1446
 Thr Pro Gly Ser Ser Trp Gly Glu Ser Ser Ser Gly Arg Ile Thr Asn
     455                 460                 465

 tgg ctt gtt cta aaa aac ctt aca cct cag atc gat ggc tca act ctg     1494
 Trp Leu Val Leu Lys Asn Leu Thr Pro Gln Ile Asp Gly Ser Thr Leu
 470                 475                 480                 485

 cgc act ctg tgc atg cag cac ggc ccg ctg atc aca ttc cac ctg aac     1542
 Arg Thr Leu Cys Met Gln His Gly Pro Leu Ile Thr Phe His Leu Asn
                 490                 495                 500

 ctc cct cac gga aat gct ctg gtc cgc tac agt tca aaa gaa gag gta     1590
 Leu Pro His Gly Asn Ala Leu Val Arg Tyr Ser Ser Lys Glu Glu Val
             505                 510                 515

 gtg aag gca caa aag tct ctg cac atg tgt gta ctg ggg aac act act     1638
 Val Lys Ala Gln Lys Ser Leu His Met Cys Val Leu Gly Asn Thr Thr
         520                 525                 530

 att ctt gct gag ttt gcc agt gaa gag gag atc agt cgt ttc ttt gca     1686
 Ile Leu Ala Glu Phe Ala Ser Glu Glu Glu Ile Ser Arg Phe Phe Ala
     535                 540                 545

 caa agc cag tct ctg acc cct tct ccc ggc tgg cag tct ctc ggg tcc     1734
 Gln Ser Gln Ser Leu Thr Pro Ser Pro Gly Trp Gln Ser Leu Gly Ser
 550                 555                 560                 565

 agc cag agc cgg ctg ggc tcc ctc gac tgt tcc cac tca ttc tcc agc     1782
 Ser Gln Ser Arg Leu Gly Ser Leu Asp Cys Ser His Ser Phe Ser Ser
                 570                 575                 580

 cgg acc gat ctc aat cac tgg aat ggt gct ggg ctg tcg gga act aac     1830
 Arg Thr Asp Leu Asn His Trp Asn Gly Ala Gly Leu Ser Gly Thr Asn
             585                 590                 595

 tgt gga gac ctt cac ggc act tca ctc tgg ggg acc ccg cat tat tcc     1878
 Cys Gly Asp Leu His Gly Thr Ser Leu Trp Gly Thr Pro His Tyr Ser
         600                 605                 610

 aca agc ctg tgg ggt ccc cca agc agc agc gac ccc cga gga att agc     1926
 Thr Ser Leu Trp Gly Pro Pro Ser Ser Ser Asp Pro Arg Gly Ile Ser
     615                 620                 625

 agc cca tct ccc att aac gct ttt ctt tct gtt gac cac ctg ggt ggg     1974
 Ser Pro Ser Pro Ile Asn Ala Phe Leu Ser Val Asp His Leu Gly Gly
 630                 635                 640                 645

 ggt gga gag tcc atg taa cagtgt agatgcagac tcaccgaccg ggacctcaga     2028
 Gly Gly Glu Ser Met 
                 650

 cgcgagggaa aggagcacta agtggggctc gccgcctgca gccaggggcc gcctgtggga   2088

 acagctattc tctgcacttt gaataggctt tccattttgt tttggaggtt ctcactttga   2148

 accttcttgt ttacagattt ttttgtttgt tttttgagaa aaaaaaatgt ttactcttcc   2208

 atcatttaaa aaaaatgtaa aagacaaaaa aaaaatggag gatgatttaa aagatgcttt   2268

 ctatctctgg gaaaaaggag cagcatttgg ccatgttctt ttgtttttct attcctgtcc   2328

 caaatcaaag agcatggttc tcaggaaaac cagttcccca gtttaaaaaa aaaaaaaaaa   2388

 aaaattcctt gtagtttctt agaggaaaaa aagaaaaacc ccaactttta gcactgatac   2448

 tacatattgc tctgttaaag aattttctct gccaaaaaaa aaagaaaaaa caaaaaaacg   2508

 cttaaagctg gagtttgaca ttctgctttc agatgctgtc tttttattag tgagtgatga   2568

 tggtttgcta ataatcaata ggtaataatt ttttgtaatc ccatcaagtg gctccatatg   2628

 tttctgctct ctcgtgactg tgttaatgtt taactgttgt accttaaagc cgaaatcagt   2688

 aactatgcat actgtaacca aggtattggg cttacagagt tgtttgttgt ataaagaaaa   2748

 ttttaaatgt tgttgcaaac taacgagtta caccatttta aactttcttt cctcccccct   2808

 ttttttgccc acaaatggta ttataatgct tgcttagtca aagaagagag actaaacaag   2868

 ggtaaaaatt ttaacagtac agaatttgcc atcatatcat tgccttgatt ctaactgttt   2928

 gtgtcctaag atgcaaaaga agtcagtggc ttttaactgt ttacaaatag aatgtgattg   2988

 taaaatgtac agtttggttg tgtttgaatt atgaaatttc ttcagatata ataaaccatg   3048

 actttttggc tgctcaac                                                 3066




      <210> 249
      <211> 751
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (49)..(708)

      <400> 249
 cgggtcgacg atttcgtctg cagttggttc ccggcgggag acgcaggg atg gaa gct      57
                                                      Met Glu Ala
                                                        1

 tcc tgg cgc cag gtg gcc ggt ggc cga ggc cga tcc cgg gga cgg gcc      105
 Ser Trp Arg Gln Val Ala Gly Gly Arg Gly Arg Ser Arg Gly Arg Ala
       5                  10                  15

 act gcc gcc ccc tca gga aat gga gtc cat ctc cgc ggc gcc gga gga      153
 Thr Ala Ala Pro Ser Gly Asn Gly Val His Leu Arg Gly Ala Gly Gly
  20                  25                  30                  35

 ggg cga gag aag ggg tcg gtg ggc gca gtt cct tct ggc acc agt ccc      201
 Gly Arg Glu Lys Gly Ser Val Gly Ala Val Pro Ser Gly Thr Ser Pro
                  40                  45                  50

 gga gga gtc gcg acc acg gcg gct gca ggg agc agg cac agc ccc gca      249
 Gly Gly Val Ala Thr Thr Ala Ala Ala Gly Ser Arg His Ser Pro Ala
              55                  60                  65

 gga tcc caa gcc ctg cag act acc gca gcc agc gag cta atg tct cag      297
 Gly Ser Gln Ala Leu Gln Thr Thr Ala Ala Ser Glu Leu Met Ser Gln
          70                  75                  80

 aaa aaa ttt gaa gaa atc aag aaa gct aac caa gct gca gcc aga aaa      345
 Lys Lys Phe Glu Glu Ile Lys Lys Ala Asn Gln Ala Ala Ala Arg Lys
      85                  90                  95

 ctt gtt gaa gaa cag ttt agc tct tca tct gaa gaa gga gat gaa gat      393
 Leu Val Glu Glu Gln Phe Ser Ser Ser Ser Glu Glu Gly Asp Glu Asp
 100                 105                 110                 115

 ttt gaa gga aaa cag gga aaa ata ctt gca aat acg ttt ata aca tac      441
 Phe Glu Gly Lys Gln Gly Lys Ile Leu Ala Asn Thr Phe Ile Thr Tyr
                 120                 125                 130

 act act cag aca gat gga gat aca cgt gaa tta gag cga aca aaa caa      489
 Thr Thr Gln Thr Asp Gly Asp Thr Arg Glu Leu Glu Arg Thr Lys Gln
             135                 140                 145

 tat gta aat gaa gct ttt caa gca ggg gct atg aca tgc cta att tgt      537
 Tyr Val Asn Glu Ala Phe Gln Ala Gly Ala Met Thr Cys Leu Ile Cys
         150                 155                 160

 att gct tcg gtg aag aga aac caa gca gtt tgg agc tgt tcg gga tgt      585
 Ile Ala Ser Val Lys Arg Asn Gln Ala Val Trp Ser Cys Ser Gly Cys
     165                 170                 175

 ttc tgt ata ttt cac atg ccc tgt atc cag aag tgg gct aaa gac acg      633
 Phe Cys Ile Phe His Met Pro Cys Ile Gln Lys Trp Ala Lys Asp Thr
 180                 185                 190                 195

 cag ttt ctt gta tct tct gtg act gat gat gat tct gga aag aaa gat      681
 Gln Phe Leu Val Ser Ser Val Thr Asp Asp Asp Ser Gly Lys Lys Asp
                 200                 205                 210

 tgt ccc tgg cct tgt cca aag atg tag gtttg aatccaaccg atctgaaaca      733
 Cys Pro Trp Pro Cys Pro Lys Met 
             215

 cctactacgt actatcgc                                                  751




      <210> 250
      <211> 2155
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (625)..(1680)

      <400> 250
 gtccatacac cgaaccaact gctcctccga ttgtgagtat tcagtgaacc ctgcccccgc     60

 ctttggggaa ggtcgggcag acaggccact gggaccaaaa gcagagtagg tagaacctct    120

 ctgagttcct ccctatttat ggcatccact caggtgaggc tgggggcgtc cttaccttgc    180

 gctttggctg ctcaggacaa acgccctgcc attcgtccct tctctctgtc cggacgccct    240

 cctccatccc tgcacttggg gccgtcgtgg ggctggtagg ggtccccagg ctatctccag    300

 ccgtggccga tggccgtgcc gggggcagag cccgctcccc tccgcgcgtt gctacgtgcg    360

 gggatgacat ggatccagac gccgtcaact acgggaagga ggaggcgaga gttggagcgc    420

 gtgggagcgc agaggccgga ggagggaggg ggggacaccg agcgcggaga gcgcggagag    480

 cgcggaggga ggcgcgcgcg ggagcgaaca ccctcccgga tccagagccc ggcggcggcg    540

 aagcagcagc tgcggccgcg cccttgccag agccggtgcg tccgcctagc cccgctccgc    600

 ctgaggccgt cagggctccc gagg   atg gaa gat tcc cag gag aca tcg ccg     651
                              Met Glu Asp Ser Gln Glu Thr Ser Pro
                                1               5

 tcc tcc aac aac tcc tcg gag gag ctc agc tct gct ctg cac ctg tcc      699
 Ser Ser Asn Asn Ser Ser Glu Glu Leu Ser Ser Ala Leu His Leu Ser
  10                  15                  20                  25

 aag ggc atg tcg atc ttc ctc gac ata ctg agg aga gca gac aaa aat      747
 Lys Gly Met Ser Ile Phe Leu Asp Ile Leu Arg Arg Ala Asp Lys Asn
                  30                  35                  40

 gat gat gga aaa tta tcc ttt gaa gaa ttc aaa gca tat ttt gca gat      795
 Asp Asp Gly Lys Leu Ser Phe Glu Glu Phe Lys Ala Tyr Phe Ala Asp
              45                  50                  55

 ggt gtt ctc agt gga gaa gaa tta cac gag ctt ttc cat acc att gat      843
 Gly Val Leu Ser Gly Glu Glu Leu His Glu Leu Phe His Thr Ile Asp
          60                  65                  70

 aca cat aat act aat aat ctt gac aca gaa gag cta tgt gaa tat ttt      891
 Thr His Asn Thr Asn Asn Leu Asp Thr Glu Glu Leu Cys Glu Tyr Phe
      75                  80                  85

 tct cag cac ttg ggc gag tat gag aat gta cta gca gca ctt gaa gac      939
 Ser Gln His Leu Gly Glu Tyr Glu Asn Val Leu Ala Ala Leu Glu Asp
  90                  95                 100                 105

 ctg aat ctt tcc atc ctg aag gca atg ggc aaa aca aag aaa gac tac      987
 Leu Asn Leu Ser Ile Leu Lys Ala Met Gly Lys Thr Lys Lys Asp Tyr
                 110                 115                 120

 caa gaa gcc tcc aat ttg gaa caa ttc gta act aga ttt tta ttg aag     1035
 Gln Glu Ala Ser Asn Leu Glu Gln Phe Val Thr Arg Phe Leu Leu Lys
             125                 130                 135

 gaa acc ctg aat cag ctg cag tct ctc cag aat tcc ctg gaa tgt gcc     1083
 Glu Thr Leu Asn Gln Leu Gln Ser Leu Gln Asn Ser Leu Glu Cys Ala
         140                 145                 150

 atg gaa act act gag gag caa acc cgt caa gaa agg caa ggg cca gcc     1131
 Met Glu Thr Thr Glu Glu Gln Thr Arg Gln Glu Arg Gln Gly Pro Ala
     155                 160                 165

 aag cca gaa gtc ctg tcg att caa tgg cct gga aaa cga tca agc cgc     1179
 Lys Pro Glu Val Leu Ser Ile Gln Trp Pro Gly Lys Arg Ser Ser Arg
 170                 175                 180                 185

 cga gtc cag aga cac aac agc ttc tcc cca aac agc cct cag ttt aat     1227
 Arg Val Gln Arg His Asn Ser Phe Ser Pro Asn Ser Pro Gln Phe Asn
                 190                 195                 200

 gtc agc ggt cca ggc tta tta gaa gaa gac aac cag tgg atg acc cag     1275
 Val Ser Gly Pro Gly Leu Leu Glu Glu Asp Asn Gln Trp Met Thr Gln
             205                 210                 215

 ata aat aga ctc cag aaa tta att gat aga ctg gaa aag aag gat ctc     1323
 Ile Asn Arg Leu Gln Lys Leu Ile Asp Arg Leu Glu Lys Lys Asp Leu
         220                 225                 230

 aaa ctc gaa cca cca gaa gaa gaa att att gaa ggg aat act aaa tct     1371
 Lys Leu Glu Pro Pro Glu Glu Glu Ile Ile Glu Gly Asn Thr Lys Ser
     235                 240                 245

 cac atc atg ctt gtg cag cgg cag atg tct gtg ata gaa gag gac ctg     1419
 His Ile Met Leu Val Gln Arg Gln Met Ser Val Ile Glu Glu Asp Leu
 250                 255                 260                 265

 gaa gaa ttc cag ctc gct ctg aaa cac tac gtg gag agt gct tcc tcc     1467
 Glu Glu Phe Gln Leu Ala Leu Lys His Tyr Val Glu Ser Ala Ser Ser
                 270                 275                 280

 caa agt gga tgc ttg cgt att tct ata cag aag ctt tca aat gaa tct     1515
 Gln Ser Gly Cys Leu Arg Ile Ser Ile Gln Lys Leu Ser Asn Glu Ser
             285                 290                 295

 cgc tac atg atc tat gag ttc tgg gag aat agt agt gta tgg aat agc     1563
 Arg Tyr Met Ile Tyr Glu Phe Trp Glu Asn Ser Ser Val Trp Asn Ser
         300                 305                 310

 cac ctt cag aca aat tat agc aag aca ttc caa aga agt aat gtg gat     1611
 His Leu Gln Thr Asn Tyr Ser Lys Thr Phe Gln Arg Ser Asn Val Asp
     315                 320                 325

 ttc ttg gaa act cca gaa ctc aca tct aca atg cta gtt cct gct tcg     1659
 Phe Leu Glu Thr Pro Glu Leu Thr Ser Thr Met Leu Val Pro Ala Ser
 330                 335                 340                 345

 tgg tgg atc ctg aac aac tag at gttcctagac attttcttta tggttccaag     1712
 Trp Trp Ile Leu Asn Asn 
                 350

 tgcaaaacag gtgttcttat ctaaaacgtc aattagaaaa ttatctgcgg ttgttaatct   1772

 actgtatatt tttgtttggt atatttacta agtgcactct ttcaaaactt attctataac   1832

 tttatcaatt catgtgaatt ttagctcaat tttcaaagtt cactaatatt ctcaatattt   1892

 aatgctaaat gctttgctac attgtaactc acctaaaacc ttttagtgac aaaatcctaa   1952

 tatgtggaaa aaagcatatg cataaaggaa taatattgtg aaaatgaatc tgttatgata   2012

 aagaaaaaat aaagtggaaa cttttagagt attacttcat agggcagatt ttgtaaactg   2072

 tcgtatactg taaaggcgtt aaatcagcgt tttgtgattt ttaagtactg tgagtgaagt   2132

 ttattcttca acaatctcgt gcc                                           2155




      <210> 251
      <211> 372
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(372)

      <400> 251
  atg gag ggg ctg gtt gtc gcc gcc ggc ggg gac gtc tcc ctg cac aac      48
  Met Glu Gly Leu Val Val Ala Ala Gly Gly Asp Val Ser Leu His Asn
    1               5                  10                  15

 ttc agc gcg agg ctg tgg gag cag ctg gtc cac ttc cac gtc atg cgg       96
 Phe Ser Ala Arg Leu Trp Glu Gln Leu Val His Phe His Val Met Arg
              20                  25                  30

 ctg acg gac tcg ctg ttc ctg tgg gtg ggg gcc acg ccg cac ctg cgc      144
 Leu Thr Asp Ser Leu Phe Leu Trp Val Gly Ala Thr Pro His Leu Arg
          35                  40                  45

 aac ctc gcc gtg gcc atg tgc agc cgc tac gac tcc atc ccc gtg tct      192
 Asn Leu Ala Val Ala Met Cys Ser Arg Tyr Asp Ser Ile Pro Val Ser
      50                  55                  60

 acc tcc ctc ctt gga gac act tcc gac acg acc tct act ggc ctt gcc      240
 Thr Ser Leu Leu Gly Asp Thr Ser Asp Thr Thr Ser Thr Gly Leu Ala
  65                  70                  75                  80

 cag cgc cta gcc agg aag acc aac aaa cag gtg ttt gtc agc tat aac      288
 Gln Arg Leu Ala Arg Lys Thr Asn Lys Gln Val Phe Val Ser Tyr Asn
                  85                  90                  95

 ctt cag aac aca gac agt aac ttc gca tta ctt gta gaa aac agg atc      336
 Leu Gln Asn Thr Asp Ser Asn Phe Ala Leu Leu Val Glu Asn Arg Ile
             100                 105                 110

 aag gaa gag atg gag gct ttc ccc gaa aag ttc tag                      372
 Lys Glu Glu Met Glu Ala Phe Pro Glu Lys Phe 
         115                 120





      <210> 252
      <211> 318
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(318)

      <400> 252
  atg gct ctg cgc tac cct atg gcc atg ggc ctc aac aag ggc cac aag      48
  Met Ala Leu Arg Tyr Pro Met Ala Met Gly Leu Asn Lys Gly His Lys
    1               5                  10                  15

 gtg acc aag aac gtg agc aag ccc agg cac agc cgc tgc agt ggg tgt       96
 Val Thr Lys Asn Val Ser Lys Pro Arg His Ser Arg Cys Ser Gly Cys
              20                  25                  30

 ctg acc aaa tac act gag ttt gtg cgg gac atg atc cgg gag gtg tgt      144
 Leu Thr Lys Tyr Thr Glu Phe Val Arg Asp Met Ile Arg Glu Val Cys
          35                  40                  45

 ggc ttt gcc ctg tac aag cag cat gct atg gag tta ctg aag gtc tcc      192
 Gly Phe Ala Leu Tyr Lys Gln His Ala Met Glu Leu Leu Lys Val Ser
      50                  55                  60

 aag gac aaa caa gcc ctc aag ttc atc aag aaa agg gtg ggg aca cac      240
 Lys Asp Lys Gln Ala Leu Lys Phe Ile Lys Lys Arg Val Gly Thr His
  65                  70                  75                  80

 atc cac acc aag agg aag cgg gag gag ctg agc aat gtc ctg gcc atc      288
 Ile His Thr Lys Arg Lys Arg Glu Glu Leu Ser Asn Val Leu Ala Ile
                  85                  90                  95

 acg agg aaa gtt gct gct atg aaa gac tga                              318
 Thr Arg Lys Val Ala Ala Met Lys Asp 
             100                 105





      <210> 253
      <211> 3067
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (193)..(1950)

      <400> 253
 ggggctgcag gggccagagc gagtgcgcct cctgcccgcg gaccgcggca gcccagagca     60

 gaaacggctt acaaaatata cagatcttgg tagacaacgt ggctgcaggc tgttgaattg    120

 gaattccctg tggctgtccg aaggcagggt gtccggagag cggtgggctg acctgttcct    180

 acaccttgca tc    atg cca gct ttg tca acg gga tct ggg agt gac act     228
                  Met Pro Ala Leu Ser Thr Gly Ser Gly Ser Asp Thr
                    1               5                  10

 ggt ctg tat gag ctg ttg gct gct ctg cca gcc cag ctg cag cca cat      276
 Gly Leu Tyr Glu Leu Leu Ala Ala Leu Pro Ala Gln Leu Gln Pro His
          15                  20                  25

 gtg gat agc cag gaa gac ctg acc ttc ctc tgg gat atg ttt ggt gaa      324
 Val Asp Ser Gln Glu Asp Leu Thr Phe Leu Trp Asp Met Phe Gly Glu
      30                  35                  40

 aaa agc ctg cat tca ttg gta aag att cat gaa aaa cta cac tac tat      372
 Lys Ser Leu His Ser Leu Val Lys Ile His Glu Lys Leu His Tyr Tyr
  45                  50                  55                  60

 gag aag cag agt ccg gtg ccc att ctc cat ggt gcg gcg gcc ttg gcc      420
 Glu Lys Gln Ser Pro Val Pro Ile Leu His Gly Ala Ala Ala Leu Ala
                  65                  70                  75

 gat gat ctg gcc gaa gag ctt cag aac aag cca tta aac agt gag atc      468
 Asp Asp Leu Ala Glu Glu Leu Gln Asn Lys Pro Leu Asn Ser Glu Ile
              80                  85                  90

 aga gag ctg ttg aaa cta ctg tca aaa ccc aat gtg aag gct ttg ctc      516
 Arg Glu Leu Leu Lys Leu Leu Ser Lys Pro Asn Val Lys Ala Leu Leu
          95                 100                 105

 tct gta cat gat act gtg gct cag aag aat tac gac cca gtg ttg cct      564
 Ser Val His Asp Thr Val Ala Gln Lys Asn Tyr Asp Pro Val Leu Pro
     110                 115                 120

 cct atg cct gaa gat att gac gat gag gaa gac tca gta aaa ata atc      612
 Pro Met Pro Glu Asp Ile Asp Asp Glu Glu Asp Ser Val Lys Ile Ile
 125                 130                 135                 140

 cgt ctg gtc aaa aat aga gaa cca ctg gga gct acc att aag aag gat      660
 Arg Leu Val Lys Asn Arg Glu Pro Leu Gly Ala Thr Ile Lys Lys Asp
                 145                 150                 155

 gaa cag acc ggg gcg atc att gtg gcc aga atc atg aga gga gga gct      708
 Glu Gln Thr Gly Ala Ile Ile Val Ala Arg Ile Met Arg Gly Gly Ala
             160                 165                 170

 gca gat aga agt ggt ctt att cat gtt ggt gat gaa ctt agg gaa gtc      756
 Ala Asp Arg Ser Gly Leu Ile His Val Gly Asp Glu Leu Arg Glu Val
         175                 180                 185

 aac ggg ata cca gtg gag gat aaa agg cct gag gaa ata ata cag att      804
 Asn Gly Ile Pro Val Glu Asp Lys Arg Pro Glu Glu Ile Ile Gln Ile
     190                 195                 200

 ttg gct cag tct cag gga gca att aca ttt aag att ata ccc ggc agc      852
 Leu Ala Gln Ser Gln Gly Ala Ile Thr Phe Lys Ile Ile Pro Gly Ser
 205                 210                 215                 220

 aaa gag gag aca cca tca aaa gaa ggc aag atg ttt atc aaa gcc ctc      900
 Lys Glu Glu Thr Pro Ser Lys Glu Gly Lys Met Phe Ile Lys Ala Leu
                 225                 230                 235

 ttt gac tat aat cct aat gag gat aag gca att cca tgt aag gaa gct      948
 Phe Asp Tyr Asn Pro Asn Glu Asp Lys Ala Ile Pro Cys Lys Glu Ala
             240                 245                 250

 ggg ctt tct ttc aaa aag gga gat att ctt cag att atg agc caa gat      996
 Gly Leu Ser Phe Lys Lys Gly Asp Ile Leu Gln Ile Met Ser Gln Asp
         255                 260                 265

 gat gca act tgg tgg caa gcg aaa cac gaa gct gat gcc aac ccc agg     1044
 Asp Ala Thr Trp Trp Gln Ala Lys His Glu Ala Asp Ala Asn Pro Arg
     270                 275                 280

 gca ggc ttg atc ccc tca aag cat ttc cag gaa agg aga ttg gct ttg     1092
 Ala Gly Leu Ile Pro Ser Lys His Phe Gln Glu Arg Arg Leu Ala Leu
 285                 290                 295                 300

 aga cga cca gaa ata ttg gtt cag ccc ctg aaa gtt tcc aac agg aaa     1140
 Arg Arg Pro Glu Ile Leu Val Gln Pro Leu Lys Val Ser Asn Arg Lys
                 305                 310                 315

 tca tct ggt ttt aga aaa agt ttt cgt ctt agt aga aaa gat aag aaa     1188
 Ser Ser Gly Phe Arg Lys Ser Phe Arg Leu Ser Arg Lys Asp Lys Lys
             320                 325                 330

 aca aat aaa tcc atg tat gaa tgc aag aag agt gat cag tac gac aca     1236
 Thr Asn Lys Ser Met Tyr Glu Cys Lys Lys Ser Asp Gln Tyr Asp Thr
         335                 340                 345

 gct gac gta ccc aca tac gaa gaa gtg aca ccg tat cgg cga caa act     1284
 Ala Asp Val Pro Thr Tyr Glu Glu Val Thr Pro Tyr Arg Arg Gln Thr
     350                 355                 360

 aat gaa aaa tac aga ctc gtt gtc ttg gtt ggt ccc gtg gga gta ggg     1332
 Asn Glu Lys Tyr Arg Leu Val Val Leu Val Gly Pro Val Gly Val Gly
 365                 370                 375                 380

 ctg aat gaa ctg aaa cga aag ctg ctg atc agt gac acc cag cac tat     1380
 Leu Asn Glu Leu Lys Arg Lys Leu Leu Ile Ser Asp Thr Gln His Tyr
                 385                 390                 395

 ggc gtg aca gtg ccc cat acc acc aga gca aga aga agc cag gag agt     1428
 Gly Val Thr Val Pro His Thr Thr Arg Ala Arg Arg Ser Gln Glu Ser
             400                 405                 410

 gat ggt gtt gaa tac att ttc att tcc aag cat ttg ttt gag aca gat     1476
 Asp Gly Val Glu Tyr Ile Phe Ile Ser Lys His Leu Phe Glu Thr Asp
         415                 420                 425

 gta caa aat aac aag ttt att gaa tat gga gaa tat aaa aac aac tac     1524
 Val Gln Asn Asn Lys Phe Ile Glu Tyr Gly Glu Tyr Lys Asn Asn Tyr
     430                 435                 440

 tac ggc aca agt ata gac tca gtt cgg tct gtc ctt gct aaa aac aaa     1572
 Tyr Gly Thr Ser Ile Asp Ser Val Arg Ser Val Leu Ala Lys Asn Lys
 445                 450                 455                 460

 gtt tgt ttg ttg gat gtt cag cct cat aca gtg aag cat tta agg aca     1620
 Val Cys Leu Leu Asp Val Gln Pro His Thr Val Lys His Leu Arg Thr
                 465                 470                 475

 cta gaa ttt aag ccc tat gtg ata ttt ata aag cct cca tca ata gag     1668
 Leu Glu Phe Lys Pro Tyr Val Ile Phe Ile Lys Pro Pro Ser Ile Glu
             480                 485                 490

 cgt ttg aga gaa aca aga aaa aat gca aag att att tca agc aga gat     1716
 Arg Leu Arg Glu Thr Arg Lys Asn Ala Lys Ile Ile Ser Ser Arg Asp
         495                 500                 505

 gac caa ggt gct gca aaa ccc ttc aca gta agt ata atg atg ctt ggg     1764
 Asp Gln Gly Ala Ala Lys Pro Phe Thr Val Ser Ile Met Met Leu Gly
     510                 515                 520

 ggc cag gaa gaa gat ttt caa gaa atg att aaa tct gca cag ata atg     1812
 Gly Gln Glu Glu Asp Phe Gln Glu Met Ile Lys Ser Ala Gln Ile Met
 525                 530                 535                 540

 gaa agt caa tat ggt cat ctt ttt gac aaa att ata ata aat gat gac     1860
 Glu Ser Gln Tyr Gly His Leu Phe Asp Lys Ile Ile Ile Asn Asp Asp
                 545                 550                 555

 ctc act gtg gca ttc aat gag ctc aaa aca act ttt gac aaa tta gag     1908
 Leu Thr Val Ala Phe Asn Glu Leu Lys Thr Thr Phe Asp Lys Leu Glu
             560                 565                 570

 aca gag acc cat tgg gtg cca gtg agc tgg tta cat tca taa ctaagag     1957
 Thr Glu Thr His Trp Val Pro Val Ser Trp Leu His Ser 
         575                 580                 585

 aaatttccat aattgtcttt ttctatagag tgcatgatga aatcaattac agttttggta   2017

 gtagggtttt taaatctata tcactgtcat agatgtacaa tcttggttca agttgaatgc   2077

 tggtttcgtc ttgtatcttt ttacagcctt atttcaaacg ccatgtgtta gtcataagat   2137

 ccgaaatcaa aatatgcaca gtactgtatt ctaagcaaaa cctcaaacct tctcgttgtc   2197

 ttcaataccg ctctatctcc aagatgaggc tgaaattttc agagagactt agctagaggc   2257

 ttagtatgta tgggagttca gcgcttctgc tggtctcagg tgtggctgct gctgtcgagt   2317

 ttgaatgtta gctgttgaag gtatcaattc agcagccatg agcagctcca gacagacagg   2377

 tgagctctgc tgtttctggg tggatcatca cagatttagc cgggcaggca gtaaggtgtc   2437

 ctcttactat tcaaaaagtg tagactttct tacatattcg caatacgttc acagtgtgtg   2497

 cattttaaaa taattcttaa aggagtaact gaaattttac cttgagtgaa tggccttcat   2557

 aatatagctt gaggagtcct tttgagtacc tgtcagtgac tcaacaacat ttaataaggg   2617

 aaagtagact tttaacagtt attatatatg taacgaaaag cctttccttt gggattaata   2677

 taagtaagaa tggtagcctt gtggcaagaa atgattacaa aggatatttt tatttgtaat   2737

 tcctcagaag acaatttatg acagtcaccc caacaatgtt tctttttgac ggcgtggttt   2797

 tggagttatc cccaactaac tttcgaacga caggggcttc gtaattccgt aaaacattgt   2857

 acacacctgt ttaccttctt cacttggtgc cattacagga tttcatttca tcctctgtgg   2917

 acatcgatca cccatcttta catgggctac gaattctttt cgccacactc gccggtgcgg   2977

 tcattcttgg cgcacactgc tgtaacactg cagacacata cctgcattgt aagagttggc   3037

 cggactattg gaataacagg tgcactctgg                                    3067




      <210> 254
      <211> 1350
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (190)..(1350)

      <400> 254
 ccaagatcag tcagcccacg gtgtgctcca cgccataaag ttctaagtcc aaagtgagcc     60

 cgtcctagct ctggggcgag agaaaacagg cctctttcgc ccctgcaggt gagggtcccg    120

 gaccgcccgg aggcaggttc ctcatccaga cctactggcc aggactcctc cacactattc    180

 cgtgcagcc    atg acg cac gca gac cgc agc act tcg tca gcg aag aag     228
              Met Thr His Ala Asp Arg Ser Thr Ser Ser Ala Lys Lys
                1               5                  10

 ccg ctg agc gcg agg cgc ttc ttc gcg gct tct caa gca ccg ttc aaa      276
 Pro Leu Ser Ala Arg Arg Phe Phe Ala Ala Ser Gln Ala Pro Phe Lys
      15                  20                  25

 ccg cgc gtc ggg ccc aag tgc cta gct tcg agt cgc aaa gcc tca gat      324
 Pro Arg Val Gly Pro Lys Cys Leu Ala Ser Ser Arg Lys Ala Ser Asp
  30                  35                  40                  45

 gtc cac cct att caa gga gaa tgg act gaa aag acg acg acc ccg gga      372
 Val His Pro Ile Gln Gly Glu Trp Thr Glu Lys Thr Thr Thr Pro Gly
                  50                  55                  60

 gga gga ggc gag aag atg gcg gac gac ccc agt gct gcc gac agg aac      420
 Gly Gly Gly Glu Lys Met Ala Asp Asp Pro Ser Ala Ala Asp Arg Asn
              65                  70                  75

 gtg gag atc tgg aag atc aag aag ctc att aag agc ttg gag gcg gcc      468
 Val Glu Ile Trp Lys Ile Lys Lys Leu Ile Lys Ser Leu Glu Ala Ala
          80                  85                  90

 cgc ggc aat ggc acc agc atg ata tca ttg atc att cct ccc aaa gac      516
 Arg Gly Asn Gly Thr Ser Met Ile Ser Leu Ile Ile Pro Pro Lys Asp
      95                 100                 105

 cag att tca cga gtg gca aaa atg tta gcg gat gag ttt gga act gca      564
 Gln Ile Ser Arg Val Ala Lys Met Leu Ala Asp Glu Phe Gly Thr Ala
 110                 115                 120                 125

 tct aac att aag tca cga gta aac cgc ctt tca gtc ctg gga gcc att      612
 Ser Asn Ile Lys Ser Arg Val Asn Arg Leu Ser Val Leu Gly Ala Ile
                 130                 135                 140

 aca tct gta caa caa aga ctc aaa ctt tat aac aaa gta cct cca aat      660
 Thr Ser Val Gln Gln Arg Leu Lys Leu Tyr Asn Lys Val Pro Pro Asn
             145                 150                 155

 ggt ctg gtt gta tac tgt gga aca att gta aca gaa gaa gga aag gaa      708
 Gly Leu Val Val Tyr Cys Gly Thr Ile Val Thr Glu Glu Gly Lys Glu
         160                 165                 170

 aag aaa gtc aac att gac ttt gaa cct ttc aaa cca att aat acg tca      756
 Lys Lys Val Asn Ile Asp Phe Glu Pro Phe Lys Pro Ile Asn Thr Ser
     175                 180                 185

 ttg tat ttg tgt gac aac aaa ttc cat aca gag gct ctt aca gca cta      804
 Leu Tyr Leu Cys Asp Asn Lys Phe His Thr Glu Ala Leu Thr Ala Leu
 190                 195                 200                 205

 ctt tca gat gat agc aag ttt gga ttc att gta ata gat ggt agt ggt      852
 Leu Ser Asp Asp Ser Lys Phe Gly Phe Ile Val Ile Asp Gly Ser Gly
                 210                 215                 220

 gca ctt ttt ggc aca ctc caa gga aac aca aga gaa gtc ctg cac aaa      900
 Ala Leu Phe Gly Thr Leu Gln Gly Asn Thr Arg Glu Val Leu His Lys
             225                 230                 235

 ttc act gtg gat ctc cca aag aaa cac ggt aga gga ggt cag tca gcc      948
 Phe Thr Val Asp Leu Pro Lys Lys His Gly Arg Gly Gly Gln Ser Ala
         240                 245                 250

 ttg cgt ttt gcc cgt tta aga atg gaa aag cga cat aac tat gtt cgg      996
 Leu Arg Phe Ala Arg Leu Arg Met Glu Lys Arg His Asn Tyr Val Arg
     255                 260                 265

 aaa gta gca gag act gct gtg cag ctg ttt att tct ggg gac aaa gtg     1044
 Lys Val Ala Glu Thr Ala Val Gln Leu Phe Ile Ser Gly Asp Lys Val
 270                 275                 280                 285

 aat gtg gct ggt cta gtt tta gct gga tcc gct gac ttt aaa act gaa     1092
 Asn Val Ala Gly Leu Val Leu Ala Gly Ser Ala Asp Phe Lys Thr Glu
                 290                 295                 300

 cta agt caa tct gat atg ttt gat cag acc gga cag gaa cat gag ctt     1140
 Leu Ser Gln Ser Asp Met Phe Asp Gln Thr Gly Gln Glu His Glu Leu
             305                 310                 315

 atc gag agc atg ccc ctg ttg gaa tgg ttt gct aac aac tat aaa aaa     1188
 Ile Glu Ser Met Pro Leu Leu Glu Trp Phe Ala Asn Asn Tyr Lys Lys
         320                 325                 330

 ttt gga gct acg ttg gaa att gtc aca gat aaa tca caa gaa ggg tct     1236
 Phe Gly Ala Thr Leu Glu Ile Val Thr Asp Lys Ser Gln Glu Gly Ser
     335                 340                 345

 cag ttt gtg aaa gga ttt ggt gga att gga ggt atc ttg cgg tac cga     1284
 Gln Phe Val Lys Gly Phe Gly Gly Ile Gly Gly Ile Leu Arg Tyr Arg
 350                 355                 360                 365

 gta gat ttc cag gga atg gaa tac caa gga gga gac gat gaa ttt ttt     1332
 Val Asp Phe Gln Gly Met Glu Tyr Gln Gly Gly Asp Asp Glu Phe Phe
                 370                 375                 380

 gac ctt gat gac tac tag                                             1350
 Asp Leu Asp Asp Tyr 
             385





      <210> 255
      <211> 776
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (156)..(533)

      <220>
      <221> misc_feature
      <222> (1)...(776)
      <223> n = a,t,c or g

      <400> 255
 gcctgagatt ctcgcccggc acggccgccc tgagcgcccc ggccaccccc agccccggct     60

 cgcccctcag gccccgggcc tcccctcaac ccccggccgg cggcccaggc cccggatccg    120

 cgggggggga cccggccccg gggggtgcgg gcccc   atg gag ctg atg ttt gca     173
                                          Met Glu Leu Met Phe Ala
                                            1               5

 gag tgg gag gac gga gag cgc ttc tca ttc gag gat tcg gac cgt ttt      221
 Glu Trp Glu Asp Gly Glu Arg Phe Ser Phe Glu Asp Ser Asp Arg Phe
              10                  15                  20

 gag gag gat tca ctc tgt tcc ttc atc tcc gag gcc gag agc ctc tgc      269
 Glu Glu Asp Ser Leu Cys Ser Phe Ile Ser Glu Ala Glu Ser Leu Cys
          25                  30                  35

 cag aac tgg cgg gga tgg cgc aaa cag tca gcg ggg ccc aat tcc ccc      317
 Gln Asn Trp Arg Gly Trp Arg Lys Gln Ser Ala Gly Pro Asn Ser Pro
      40                  45                  50

 act ggc ggc ggt ggc gga ggt ggc agt ggc ggt acc aga atg cga ggt      365
 Thr Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Thr Arg Met Arg Gly
  55                  60                  65                  70

 gag agt gag ctg ggg gga aga gga tcg gca ggc cct gct tgg gcc tcg      413
 Glu Ser Glu Leu Gly Gly Arg Gly Ser Ala Gly Pro Ala Trp Ala Ser
                  75                  80                  85

 ctc ggg agc tgt ccg gga cca gga gct gtc ccc gac caa gag ctc tct      461
 Leu Gly Ser Cys Pro Gly Pro Gly Ala Val Pro Asp Gln Glu Leu Ser
              90                  95                 100

 tca acc agg gga aga aag ggg agc tgt ccc cgg ccg gga gct gtc ccc      509
 Ser Thr Arg Gly Arg Lys Gly Ser Cys Pro Arg Pro Gly Ala Val Pro
         105                 110                 115

 gac tgg gag ctg tcc caa gct tag aacagacttc agaactcgct tttccggcct     563
 Asp Trp Glu Leu Ser Gln Ala 
     120                 125

 tcctggggtg ggctggcttc tccacacctg tgtgtgtgtg ggtgtgtgtg tgtgtgtgtg    623

 cgcgcgcgcg cntgcncncg ctgtgacagg gataacctgt ggacagaaag aaatctttcc    683

 ccctcctttg ccttagagag ggggataggg aaaaaaatct tggctttgac ttgggaatac    743

 ttaagggagc tcagtctgga ggataccgga caa                                 776




      <210> 256
      <211> 958
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (386)..(958)

      <400> 256
 ccggtcagga aggccctggg gacaccgagg ccagccagac agagcctggc agctcggctg     60

 tgactctgca gtgaccagcc ctccctgtcc cagaatgagt cggatgtctt cagctgggtg    120

 atccgccgcg agttccagga gctgcaccac agaaaactca acagtgtacg ttttacccag    180

 tttagtggta gtttctttag tctttgcctt tttgagcttg gcaatgtgag ccacagactt    240

 gggacccagg acattgccgt cccagtgaca gtgggtctca tcgtatctgg cattgtaatt    300

 ggtcccgata gcttccatca gcttagccaa agctcctttg tcttctgagt taacctgtgt    360

 gaagtcgaca gtggtgtagg tcttc  atg ccg aaa gga aag gag gcc aag ggg     412
                              Met Pro Lys Gly Lys Glu Ala Lys Gly
                                1               5

 aag aag ttg gct ctg gcc cct gct ttt gtg aag aag cag gag gcc aag      460
 Lys Lys Leu Ala Leu Ala Pro Ala Phe Val Lys Lys Gln Glu Ala Lys
  10                  15                  20                  25

 aaa gtg gtg aat ccc ctg ttt gag aaa agg cct aag aat ttt ggc att      508
 Lys Val Val Asn Pro Leu Phe Glu Lys Arg Pro Lys Asn Phe Gly Ile
                  30                  35                  40

 gga cag gac atc cag ccc aaa aga gac ctc acc tgc ttt gtg aaa tgg      556
 Gly Gln Asp Ile Gln Pro Lys Arg Asp Leu Thr Cys Phe Val Lys Trp
              45                  50                  55

 ccc cgc tat atc agg ttg caa tgg cag aga tcc ata ctc tat aag cag      604
 Pro Arg Tyr Ile Arg Leu Gln Trp Gln Arg Ser Ile Leu Tyr Lys Gln
          60                  65                  70

 ctg aaa gtg cct cct gcg att aac cag ttc acc cag gcc ctg gaa ggc      652
 Leu Lys Val Pro Pro Ala Ile Asn Gln Phe Thr Gln Ala Leu Glu Gly
      75                  80                  85

 caa aca gct act cag ctg ctt aag ctg gcc cac aaa tac aga cca gag      700
 Gln Thr Ala Thr Gln Leu Leu Lys Leu Ala His Lys Tyr Arg Pro Glu
  90                  95                 100                 105

 aca aag caa gag aag aag cgg agg ctg ttg gcc cag gca gag ttg aag      748
 Thr Lys Gln Glu Lys Lys Arg Arg Leu Leu Ala Gln Ala Glu Leu Lys
                 110                 115                 120

 acc tac acc act gtc gac ttc aca cag gtt aac tca gaa gac aaa gga      796
 Thr Tyr Thr Thr Val Asp Phe Thr Gln Val Asn Ser Glu Asp Lys Gly
             125                 130                 135

 gct ttg gct aag ctg atg gaa gct atc ggg acc aat tac aat gcc aga      844
 Ala Leu Ala Lys Leu Met Glu Ala Ile Gly Thr Asn Tyr Asn Ala Arg
         140                 145                 150

 tac gat gag acc cac tgt cac tgg gac ggc aat gtc ctg ggt ccc aag      892
 Tyr Asp Glu Thr His Cys His Trp Asp Gly Asn Val Leu Gly Pro Lys
     155                 160                 165

 tct gtg gct cac att gcc aag ctc gaa aag gca aag gct aaa gaa ctt      940
 Ser Val Ala His Ile Ala Lys Leu Glu Lys Ala Lys Ala Lys Glu Leu
 170                 175                 180                 185

 gcc act aaa ctg ggt taa                                              958
 Ala Thr Lys Leu Gly 
                 190





      <210> 257
      <211> 1462
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (28)..(699)

      <220>
      <221> misc_feature
      <222> (1)...(1462)
      <223> n = a,t,c or g

      <400> 257
 ggcactgctc acctctcgtc cagggac    atg acg ggc acg cca ggc gcc gtt      51
                                  Met Thr Gly Thr Pro Gly Ala Val
                                    1               5

 gcc acc cgg gat ggc gag gcc ccc gag cgc tcc ccg ccc tgc agt ccg       99
 Ala Thr Arg Asp Gly Glu Ala Pro Glu Arg Ser Pro Pro Cys Ser Pro
      10                  15                  20

 agc tac gac ctc acg ggc aag gtg atg ctt ctg gga gac aca ggc gtc      147
 Ser Tyr Asp Leu Thr Gly Lys Val Met Leu Leu Gly Asp Thr Gly Val
  25                  30                  35                  40

 ggc aaa aca tgt ttc ctg atc caa ttc aaa gac ggg gcc ttc ctg tcc      195
 Gly Lys Thr Cys Phe Leu Ile Gln Phe Lys Asp Gly Ala Phe Leu Ser
                  45                  50                  55

 gga acc ttc ata gcc acc gtc ggc ata gac ttc agg aac aag gtg gtg      243
 Gly Thr Phe Ile Ala Thr Val Gly Ile Asp Phe Arg Asn Lys Val Val
              60                  65                  70

 act gtg gat ggc gtg aga gtg aag ctg cag atc tgg gac acc gct ggg      291
 Thr Val Asp Gly Val Arg Val Lys Leu Gln Ile Trp Asp Thr Ala Gly
          75                  80                  85

 cag gaa cgg ttc cga agc gtc acc cat gct tat tac aga gat gct cag      339
 Gln Glu Arg Phe Arg Ser Val Thr His Ala Tyr Tyr Arg Asp Ala Gln
      90                  95                 100

 gcc ttg ctt ctg ctg tat gac atc acc aac aaa tct tct ttc gac aac      387
 Ala Leu Leu Leu Leu Tyr Asp Ile Thr Asn Lys Ser Ser Phe Asp Asn
 105                 110                 115                 120

 atc agg gcc tgg ctc act gag att cat gag tat gcc cag agg gac gtg      435
 Ile Arg Ala Trp Leu Thr Glu Ile His Glu Tyr Ala Gln Arg Asp Val
                 125                 130                 135

 gtg atc atg ctg cta ggc aac aag gcg gat atg agc agc gaa aga gtg      483
 Val Ile Met Leu Leu Gly Asn Lys Ala Asp Met Ser Ser Glu Arg Val
             140                 145                 150

 atc cgt tcc gaa gac gga gag acc ttg gcc agg gag tac ggt gtt ccc      531
 Ile Arg Ser Glu Asp Gly Glu Thr Leu Ala Arg Glu Tyr Gly Val Pro
         155                 160                 165

 ttc ctg gag acc agc gcc aag act ggc atg aat gtg gag tta gcc ttt      579
 Phe Leu Glu Thr Ser Ala Lys Thr Gly Met Asn Val Glu Leu Ala Phe
     170                 175                 180

 ctg gcc atc gcc aag gaa ctg aaa tac cgg gcc ggg cat cag gcg gat      627
 Leu Ala Ile Ala Lys Glu Leu Lys Tyr Arg Ala Gly His Gln Ala Asp
 185                 190                 195                 200

 gag ccc agc ttc cag atc cga gac tat gta gag tcc cag aag aag cgc      675
 Glu Pro Ser Phe Gln Ile Arg Asp Tyr Val Glu Ser Gln Lys Lys Arg
                 205                 210                 215

 tcc agc tgc tgc tcc ttc atg tga atcccagggg gcagagagga ggctctggag     729
 Ser Ser Cys Cys Ser Phe Met 
             220

 gcacacagga tgcagccttc cccctcccag gcctggctta ttccaagagg ctgagccaat    789

 ggggagaaag atggaggact cactgcacag ccgcttccta gcagggagct atactccaac    849

 tcctacttga gttcctgcgg tctccccgca tccacaggga gggtaaaaca cttagctttt    909

 attttaatag tacataattt aataccaaaa aaggcgcctg gatccccaaa aaaccgaggc    969

 tgggagctag tggccctttt gctttctagg acttgggggg ccggccctcc ctcctaagca   1029

 taacaaaggt ggtgttgctc cagctcagcc ccaggggaca cagatgcact ttgggggtga   1089

 gggcaggtaa tgactccatc gcaccctcag ttcagctgga cagaggctca ggtgacccca   1149

 gccttcactg tctcccgctc tccaggagct tatcttcgcc ccatctccca aataagtggg   1209

 cccttgtgct gtgaggaaga ccaaagcctc agggaagata agagatatgg agatgggagg   1269

 gggaggacaa ggggcagaga gtagggtcta gctggctatc tctggcctta ctaacacccc   1329

 cctggaggca tgcccctttt cttcagcaca caagcacatt ggggcacctn gaaatattgg   1389

 tccaggctcc tgtctctgga cttagatctc tgggagcccc tccccccctg atccctgctt   1449

 actaccttct gct                                                      1462




      <210> 258
      <211> 1299
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (233)..(1252)

      <400> 258
 tggcagacgg cgcccagcgg cggcgcgaac ggcagctagg agggttgctc cgggcttggt     60

 gctcactgcg acttcccgcg cagggcccgg tcggactagg acccgcggcc tgagagacgc    120

 tggaggatgc ggacgcggag gccgcctggg gtagcggcgg cgggagtcct ggcgctctgc    180

 aggtcagaag ttgagtagca ggggcctagg agggctcgaa gccttcacag cg    atg     235
                                                              Met
                                                                1

 gca gag aag cga ccc ctg aga acc ctg ggg cct gtg atg tat ggc aag      283
 Ala Glu Lys Arg Pro Leu Arg Thr Leu Gly Pro Val Met Tyr Gly Lys
               5                  10                  15

 ctg ccc cgc tta gag aca gac tcc ggg ctc gag cac agc ctg ccc cac      331
 Leu Pro Arg Leu Glu Thr Asp Ser Gly Leu Glu His Ser Leu Pro His
          20                  25                  30

 tct gtt ggt aac cag gat ccc tgc acc tac aag ggg tcc tac ttc tcc      379
 Ser Val Gly Asn Gln Asp Pro Cys Thr Tyr Lys Gly Ser Tyr Phe Ser
      35                  40                  45

 tgc ccc atg gcg ggt act cct aag gcc gag tct gag cag ttg gcg tcc      427
 Cys Pro Met Ala Gly Thr Pro Lys Ala Glu Ser Glu Gln Leu Ala Ser
  50                  55                  60                  65

 tgg acc cca tac cca ccc ttg tac tct acc ggt atg gca gga ccc cca      475
 Trp Thr Pro Tyr Pro Pro Leu Tyr Ser Thr Gly Met Ala Gly Pro Pro
                  70                  75                  80

 ctt cag gca gac aac ctg ctg acc aac tgc ctg ttc tac cgc tcg cca      523
 Leu Gln Ala Asp Asn Leu Leu Thr Asn Cys Leu Phe Tyr Arg Ser Pro
              85                  90                  95

 gca gaa ggc cct gag aag atg cag gac tcc agc cct gtt gag ctc ctg      571
 Ala Glu Gly Pro Glu Lys Met Gln Asp Ser Ser Pro Val Glu Leu Leu
         100                 105                 110

 ccc ttc agt ccc cag gct cac tcc tac cca ggc cca cca ctg gca gca      619
 Pro Phe Ser Pro Gln Ala His Ser Tyr Pro Gly Pro Pro Leu Ala Ala
     115                 120                 125

 ccc aaa cct gtc tac cgc aac cct ctg tgc tat ggg ctc tca act tgt      667
 Pro Lys Pro Val Tyr Arg Asn Pro Leu Cys Tyr Gly Leu Ser Thr Cys
 130                 135                 140                 145

 ctg ggg gaa gga gca gtg aag agg cca ctg gat gtt gac tgg acc ctg      715
 Leu Gly Glu Gly Ala Val Lys Arg Pro Leu Asp Val Asp Trp Thr Leu
                 150                 155                 160

 gcg act ggg ccc ctg ttg ccc tca gct gac cca ccc tgc tct ctg gcc      763
 Ala Thr Gly Pro Leu Leu Pro Ser Ala Asp Pro Pro Cys Ser Leu Ala
             165                 170                 175

 cca gct cct agc aag ggc cag act ctg gat ggc acc ttc ttg cgg ggg      811
 Pro Ala Pro Ser Lys Gly Gln Thr Leu Asp Gly Thr Phe Leu Arg Gly
         180                 185                 190

 gtg cca gct gag ggg tcc agt aaa gac tcc tca ggg agc ttc tcc cca      859
 Val Pro Ala Glu Gly Ser Ser Lys Asp Ser Ser Gly Ser Phe Ser Pro
     195                 200                 205

 tgc cag ccc ttc ctg gag aaa tat cag acc atc cac agc acg ggc ttc      907
 Cys Gln Pro Phe Leu Glu Lys Tyr Gln Thr Ile His Ser Thr Gly Phe
 210                 215                 220                 225

 ctg gcc tcc agg tac aca ggt cct tac cct agg aac tcc aag caa gca      955
 Leu Ala Ser Arg Tyr Thr Gly Pro Tyr Pro Arg Asn Ser Lys Gln Ala
                 230                 235                 240

 atg tct gag ggg ccc tca agt cct tgg acc cag ctg gcc cag ccc ctg     1003
 Met Ser Glu Gly Pro Ser Ser Pro Trp Thr Gln Leu Ala Gln Pro Leu
             245                 250                 255

 ggg cca ccc tgt cag gac acc ggg ccc acc cac tac cca cca ccc cca     1051
 Gly Pro Pro Cys Gln Asp Thr Gly Pro Thr His Tyr Pro Pro Pro Pro
         260                 265                 270

 cca ccc agc gac cac aca gcc tcc aca ggc cct gcc gaa aga ccc atc     1099
 Pro Pro Ser Asp His Thr Ala Ser Thr Gly Pro Ala Glu Arg Pro Ile
     275                 280                 285

 caa gcc tat gta cag cac cca gaa gca agc agg gac aag cat aca gac     1147
 Gln Ala Tyr Val Gln His Pro Glu Ala Ser Arg Asp Lys His Thr Asp
 290                 295                 300                 305

 cca agc cga ctc cca ccg agc aga ccc aac aag agc cag agg cca aga     1195
 Pro Ser Arg Leu Pro Pro Ser Arg Pro Asn Lys Ser Gln Arg Pro Arg
                 310                 315                 320

 aga ggg cag acg caa aac aca aga gct agg ata ggg gct gga gac aag     1243
 Arg Gly Gln Thr Gln Asn Thr Arg Ala Arg Ile Gly Ala Gly Asp Lys
             325                 330                 335

 acc cac taa gctcgca tgacagaaga gcaaacccaa ggagaccctc aacatccacc     1299
 Thr His 






      <210> 259
      <211> 3746
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (224)..(3703)

      <400> 259
 cccggaacca ggtccggact gtgttcataa gccctctgta agctggagaa agccgggccc     60

 gagagcccaa ggcgccgtta gagccgagag actgaggcgt tttgcgcctt cagaggagcc    120

 aggcctttgc ttggtctcct taattcctgg gaacctgttg tgttgcagac gaggctcctc    180

 ctgcccgcgt ggctgggcct gctgctggga ccctccctgc cag  atg ggg gtt tat     235
                                                  Met Gly Val Tyr
                                                    1

 ccc aca gac ctg acc ctg cag ctg ctg gct gtg cgg agg aag agc aga      283
 Pro Thr Asp Leu Thr Leu Gln Leu Leu Ala Val Arg Arg Lys Ser Arg
   5                  10                  15                  20

 ctg cgg gac ccc ggc cta cag cag acc ctc cgg ggc cag ctc cgc ctg      331
 Leu Arg Asp Pro Gly Leu Gln Gln Thr Leu Arg Gly Gln Leu Arg Leu
                  25                  30                  35

 ctg gag aat gat agc cgg gag atg gcc cgc gtg ctt ggg gaa tta tca      379
 Leu Glu Asn Asp Ser Arg Glu Met Ala Arg Val Leu Gly Glu Leu Ser
              40                  45                  50

 gcc agg ctg ctg tcc atc cac agt gac cag gac cgg atc gtg gtg acg      427
 Ala Arg Leu Leu Ser Ile His Ser Asp Gln Asp Arg Ile Val Val Thr
          55                  60                  65

 ttt aag act ttt gaa gaa atc tgg aag ttt tcc acc tac cat gct ctc      475
 Phe Lys Thr Phe Glu Glu Ile Trp Lys Phe Ser Thr Tyr His Ala Leu
      70                  75                  80

 ggc ttc act cat cac tgc ctg gca aac ctg ctc atg gac cag gcc ttc      523
 Gly Phe Thr His His Cys Leu Ala Asn Leu Leu Met Asp Gln Ala Phe
  85                  90                  95                 100

 tgg ctg ctc ttg ccc agt gag gag gag gag acg gcc atc caa gtc cat      571
 Trp Leu Leu Leu Pro Ser Glu Glu Glu Glu Thr Ala Ile Gln Val His
                 105                 110                 115

 gtg gat gag aac gcc tta agg ctg acc cac gag agc ctc ctc atc caa      619
 Val Asp Glu Asn Ala Leu Arg Leu Thr His Glu Ser Leu Leu Ile Gln
             120                 125                 130

 gaa ggg ccc ttc ttt gtc ctg tgt cct gac cac cat gtg aga gtg atg      667
 Glu Gly Pro Phe Phe Val Leu Cys Pro Asp His His Val Arg Val Met
         135                 140                 145

 acg ggt ccc cgg gat gca gga aat ggc ccc cag gcc ctc agg cag gct      715
 Thr Gly Pro Arg Asp Ala Gly Asn Gly Pro Gln Ala Leu Arg Gln Ala
     150                 155                 160

 tcg ggg gca ccc cag gga gag gcg gcc ccg gaa aca gac tct tca ccg      763
 Ser Gly Ala Pro Gln Gly Glu Ala Ala Pro Glu Thr Asp Ser Ser Pro
 165                 170                 175                 180

 ccg agc ccc agc gtg tcc tcc gag gag gtg gca gtg gcg gcc gcc ccg      811
 Pro Ser Pro Ser Val Ser Ser Glu Glu Val Ala Val Ala Ala Ala Pro
                 185                 190                 195

 gag cct ttg att cca ttt cat cag tgg gct ctt agg atc ccc cag gac      859
 Glu Pro Leu Ile Pro Phe His Gln Trp Ala Leu Arg Ile Pro Gln Asp
             200                 205                 210

 ccc atc gac gat gcc atg ggt ggc cct gtg atg ccc ggc aac ccg ctg      907
 Pro Ile Asp Asp Ala Met Gly Gly Pro Val Met Pro Gly Asn Pro Leu
         215                 220                 225

 atg gct gtg ggc ctg gcc tcg gca ttg gca gac ttc cag ggc tcg ggg      955
 Met Ala Val Gly Leu Ala Ser Ala Leu Ala Asp Phe Gln Gly Ser Gly
     230                 235                 240

 ccc gaa gag atg acc ttc cga ggt ggc gac ctc atc gag atc ctt ggg     1003
 Pro Glu Glu Met Thr Phe Arg Gly Gly Asp Leu Ile Glu Ile Leu Gly
 245                 250                 255                 260

 gcg cag gtg ccc agc ctg ccc tgg tgc gtg ggc cga cac gca gcc tcg     1051
 Ala Gln Val Pro Ser Leu Pro Trp Cys Val Gly Arg His Ala Ala Ser
                 265                 270                 275

 ggc cgg gtg ggg ttt gtg cgg agc agc ctc atc agc atg cag ggc ccc     1099
 Gly Arg Val Gly Phe Val Arg Ser Ser Leu Ile Ser Met Gln Gly Pro
             280                 285                 290

 gtg tcc gag ttg gaa agt gcg att ttt ctc aat gag gaa gaa aag tca     1147
 Val Ser Glu Leu Glu Ser Ala Ile Phe Leu Asn Glu Glu Glu Lys Ser
         295                 300                 305

 ttc ttc agc gag ggc tgc ttt tct gag gag gat gcc agg cag ttg ctg     1195
 Phe Phe Ser Glu Gly Cys Phe Ser Glu Glu Asp Ala Arg Gln Leu Leu
     310                 315                 320

 agg cgg atg tcg ggc acc gat gtc tgc agc gtg tac agc ctg gac tca     1243
 Arg Arg Met Ser Gly Thr Asp Val Cys Ser Val Tyr Ser Leu Asp Ser
 325                 330                 335                 340

 gta gag gaa gct gag acc gag cag ccg cag gaa aaa gaa ata cct cca     1291
 Val Glu Glu Ala Glu Thr Glu Gln Pro Gln Glu Lys Glu Ile Pro Pro
                 345                 350                 355

 cct tgc ctg agc ccg gag cca cag gag acc ttg cag aag gtg aag aat     1339
 Pro Cys Leu Ser Pro Glu Pro Gln Glu Thr Leu Gln Lys Val Lys Asn
             360                 365                 370

 gtt ctg gaa caa tgc aag acc tgc cca ggc tgc ccc cag gag cca gcg     1387
 Val Leu Glu Gln Cys Lys Thr Cys Pro Gly Cys Pro Gln Glu Pro Ala
         375                 380                 385

 tcc tgg ggt ctc tgt gcg gca tcc agc gac gtg agc ttg cag gac ccc     1435
 Ser Trp Gly Leu Cys Ala Ala Ser Ser Asp Val Ser Leu Gln Asp Pro
     390                 395                 400

 gag gag ccc tcc ttc tgc ttg gaa gcc gag gac gac tgg gag gac cca     1483
 Glu Glu Pro Ser Phe Cys Leu Glu Ala Glu Asp Asp Trp Glu Asp Pro
 405                 410                 415                 420

 gag gcc ctg agc tca ctg ctg ctg ttc ctg aac gcc cct ggg tac aag     1531
 Glu Ala Leu Ser Ser Leu Leu Leu Phe Leu Asn Ala Pro Gly Tyr Lys
                 425                 430                 435

 gcc agc ttc cgt ggc ctg tac gat gtg gcg ctg ccg tgg ctg agc agc     1579
 Ala Ser Phe Arg Gly Leu Tyr Asp Val Ala Leu Pro Trp Leu Ser Ser
             440                 445                 450

 gtg ttc cgc agc ttc agc gac gag gag gag ctg act ggg cgc ctg gca     1627
 Val Phe Arg Ser Phe Ser Asp Glu Glu Glu Leu Thr Gly Arg Leu Ala
         455                 460                 465

 cag gcc cgg ggg gcg gcc aag aaa gct ggc ctc ctc atg gcc ctg gcc     1675
 Gln Ala Arg Gly Ala Ala Lys Lys Ala Gly Leu Leu Met Ala Leu Ala
     470                 475                 480

 agg ctc tgc ttc ctc ctg ggg cgg ctg tgc agc agg agg ctc aag ctg     1723
 Arg Leu Cys Phe Leu Leu Gly Arg Leu Cys Ser Arg Arg Leu Lys Leu
 485                 490                 495                 500

 tcc cag gcc cgg gtg tac ttt gag gaa gcg ctg ggg gcc ctg gag ggc     1771
 Ser Gln Ala Arg Val Tyr Phe Glu Glu Ala Leu Gly Ala Leu Glu Gly
                 505                 510                 515

 agc ttc ggg gac ctg ttc ctg gtg gtg gct gtg tac gcc aac ctg gcc     1819
 Ser Phe Gly Asp Leu Phe Leu Val Val Ala Val Tyr Ala Asn Leu Ala
             520                 525                 530

 agc att tac cgg aag cag aag aac cgg gag aag tgt gca cag gtg gtg     1867
 Ser Ile Tyr Arg Lys Gln Lys Asn Arg Glu Lys Cys Ala Gln Val Val
         535                 540                 545

 ccc aaa gcc atg gcc ctg ctc ctg ggg acg ccc gac cac atc tgc agc     1915
 Pro Lys Ala Met Ala Leu Leu Leu Gly Thr Pro Asp His Ile Cys Ser
     550                 555                 560

 acc gag gcg gag ggg gag ctc ctg cag ctg gcg ctg cgg cgg gcg gtg     1963
 Thr Glu Ala Glu Gly Glu Leu Leu Gln Leu Ala Leu Arg Arg Ala Val
 565                 570                 575                 580

 ggt ggc cag agc ctg cag gcc gag gcc cgg gcc tgc ttc ctg ctg gcc     2011
 Gly Gly Gln Ser Leu Gln Ala Glu Ala Arg Ala Cys Phe Leu Leu Ala
                 585                 590                 595

 agg cac cac gtg cac ctc aag cag ccc gag gag gcc ctg ccc ttc cta     2059
 Arg His His Val His Leu Lys Gln Pro Glu Glu Ala Leu Pro Phe Leu
             600                 605                 610

 gag cgg ctg ctg ctt ttg cac agg gac tcg gga gcc cca gag gcc gcg     2107
 Glu Arg Leu Leu Leu Leu His Arg Asp Ser Gly Ala Pro Glu Ala Ala
         615                 620                 625

 tgg ctc tca gac tgc tac cta ctc ctg gct gac atc tac agc cgc aag     2155
 Trp Leu Ser Asp Cys Tyr Leu Leu Leu Ala Asp Ile Tyr Ser Arg Lys
     630                 635                 640

 tgc ctg ccc cac ctg gtg ctg agc tgt gtc aag gtg gcc tca ttg cgg     2203
 Cys Leu Pro His Leu Val Leu Ser Cys Val Lys Val Ala Ser Leu Arg
 645                 650                 655                 660

 aca cgg ggc tcg ctg gcc ggc tcg ctg agg agt gtg aac ctg gtg ctc     2251
 Thr Arg Gly Ser Leu Ala Gly Ser Leu Arg Ser Val Asn Leu Val Leu
                 665                 670                 675

 cag aac gcc ccc cag ccc cac agc ctc cct gcc caa act tcc cac tac     2299
 Gln Asn Ala Pro Gln Pro His Ser Leu Pro Ala Gln Thr Ser His Tyr
             680                 685                 690

 ctc agg caa gcg ctg gcc tcc ctg acc ccg ggc aca ggc cag gcg ctg     2347
 Leu Arg Gln Ala Leu Ala Ser Leu Thr Pro Gly Thr Gly Gln Ala Leu
         695                 700                 705

 cgc ggc ccc ctc tac acc agc ttg gcc cag ctg tac agc cac cat ggc     2395
 Arg Gly Pro Leu Tyr Thr Ser Leu Ala Gln Leu Tyr Ser His His Gly
     710                 715                 720

 tgc cac ggc ccg gcc atc acc ttc atg acg cag gca gtg gaa gcc agt     2443
 Cys His Gly Pro Ala Ile Thr Phe Met Thr Gln Ala Val Glu Ala Ser
 725                 730                 735                 740

 gct att gcc gga gtc cgt gcc atc gtg gac cac ctg gtg gcc ctg gcc     2491
 Ala Ile Ala Gly Val Arg Ala Ile Val Asp His Leu Val Ala Leu Ala
                 745                 750                 755

 tgg ctg cac gtg ctt cat ggg cag agc ccg gtg gcc ctg gac atc ctg     2539
 Trp Leu His Val Leu His Gly Gln Ser Pro Val Ala Leu Asp Ile Leu
             760                 765                 770

 cag tct gtc cgg gat gca gtg gtg gcc agc gag gac cag gag ggc gtg     2587
 Gln Ser Val Arg Asp Ala Val Val Ala Ser Glu Asp Gln Glu Gly Val
         775                 780                 785

 att gcc aac atg gtg gcc gtg gct ctg aag agg acg ggc cgg acg agg     2635
 Ile Ala Asn Met Val Ala Val Ala Leu Lys Arg Thr Gly Arg Thr Arg
     790                 795                 800

 cag gca gct gag agc tac tac cgc gcc ctg cgg gtg gct cgg gac ctg     2683
 Gln Ala Ala Glu Ser Tyr Tyr Arg Ala Leu Arg Val Ala Arg Asp Leu
 805                 810                 815                 820

 ggc cag caa agg aac cag gca gtg ggg ctg gcc aac ttc ggg gcc ctg     2731
 Gly Gln Gln Arg Asn Gln Ala Val Gly Leu Ala Asn Phe Gly Ala Leu
                 825                 830                 835

 tgc ctg cat gcg ggt gcc agc agg ctg gcc cag cac tac ctc ctg gag     2779
 Cys Leu His Ala Gly Ala Ser Arg Leu Ala Gln His Tyr Leu Leu Glu
             840                 845                 850

 gcc gtg cgg ctg ttc tcg agg ctg ccc ctt ggg gag tgt ggc cgg gac     2827
 Ala Val Arg Leu Phe Ser Arg Leu Pro Leu Gly Glu Cys Gly Arg Asp
         855                 860                 865

 ttc acc cac gtg ctc ctg cag ctg ggc cat ctc tgc acc cgc cag ggc     2875
 Phe Thr His Val Leu Leu Gln Leu Gly His Leu Cys Thr Arg Gln Gly
     870                 875                 880

 ccg gcc cag cag ggc aag ggc tac tac gag tgg gcc ctt ctg gtc gcc     2923
 Pro Ala Gln Gln Gly Lys Gly Tyr Tyr Glu Trp Ala Leu Leu Val Ala
 885                 890                 895                 900

 gtg gag atg ggc cac gtg gag agc cag ctg cgg gcc gtc cag cgg ctg     2971
 Val Glu Met Gly His Val Glu Ser Gln Leu Arg Ala Val Gln Arg Leu
                 905                 910                 915

 tgc cac ttc tac agc gcc gtc atg ccc agc gag gcc cag tgt gtc atc     3019
 Cys His Phe Tyr Ser Ala Val Met Pro Ser Glu Ala Gln Cys Val Ile
             920                 925                 930

 tac cat gag ctc cag ctc tcc ctg gcc tgc aag gtg gcc gac aag gtg     3067
 Tyr His Glu Leu Gln Leu Ser Leu Ala Cys Lys Val Ala Asp Lys Val
         935                 940                 945

 ctg gag ggg cag ctc ctg gag acc atc agc cag ctc tac ctg tcc ctg     3115
 Leu Glu Gly Gln Leu Leu Glu Thr Ile Ser Gln Leu Tyr Leu Ser Leu
     950                 955                 960

 ggc acc gag cgg gcc tac aaa tcc gca ctg gac tac acc aaa cga agt     3163
 Gly Thr Glu Arg Ala Tyr Lys Ser Ala Leu Asp Tyr Thr Lys Arg Ser
 965                 970                 975                 980

 ctg ggg att ttc att gac ctc cag aag aaa gag aag gag gcg cat gcc     3211
 Leu Gly Ile Phe Ile Asp Leu Gln Lys Lys Glu Lys Glu Ala His Ala
                 985                 990                 995

 tgg ctg cag gca ggg aag atc tat tac atc ttg cgg cag agc gag ctg     3259
 Trp Leu Gln Ala Gly Lys Ile Tyr Tyr Ile Leu Arg Gln Ser Glu Leu
            1000                1005                1010

 gtg gac ctc tac atc cag gtg gca cag aac gtg gcc ctg tac aca ggc     3307
 Val Asp Leu Tyr Ile Gln Val Ala Gln Asn Val Ala Leu Tyr Thr Gly
        1015                1020                1025

 gac ccc aac ctg ggg ctg gag ctg ttt gag gcg gct gga gac atc ttc     3355
 Asp Pro Asn Leu Gly Leu Glu Leu Phe Glu Ala Ala Gly Asp Ile Phe
    1030                1035                1040

 ttc gac ggg gcc tgg gag cgg gag aaa gct gtg tcc ttc tac cgg gac     3403
 Phe Asp Gly Ala Trp Glu Arg Glu Lys Ala Val Ser Phe Tyr Arg Asp
1045                1050                1055                1060

 cgg gcc ctg ccc ctg gca gtg act acg ggc aac cgc aag gcg gag ctg     3451
 Arg Ala Leu Pro Leu Ala Val Thr Thr Gly Asn Arg Lys Ala Glu Leu
                1065                1070                1075

 cgg ctg tgc aac aag ctg gtg gca ctg ctg gcc acg ctg gag gag ccc     3499
 Arg Leu Cys Asn Lys Leu Val Ala Leu Leu Ala Thr Leu Glu Glu Pro
            1080                1085                1090

 cag gag ggc ttg gag ttt gcc cac atg gcc cta gca ctc agc atc act     3547
 Gln Glu Gly Leu Glu Phe Ala His Met Ala Leu Ala Leu Ser Ile Thr
        1095                1100                1105

 ctg ggg gac cgg ctg aac gag cgc gtg gcc tac cac cgg ctg gcc gcc     3595
 Leu Gly Asp Arg Leu Asn Glu Arg Val Ala Tyr His Arg Leu Ala Ala
    1110                1115                1120

 ctg caa cac cga ctg ggc cat ggc gag ctg gca gag cac ttc tac ctc     3643
 Leu Gln His Arg Leu Gly His Gly Glu Leu Ala Glu His Phe Tyr Leu
1125                1130                1135                1140

 aag gcc ctg tcg ctc tgc aac tcg ccg ctg gag ttt gac gag gag acc     3691
 Lys Ala Leu Ser Leu Cys Asn Ser Pro Leu Glu Phe Asp Glu Glu Thr
                1145                1150                1155

 ctt tat acg tga agg tgtacctggt gctcggtgac atcatcttct acgacctgaa     3746
 Leu Tyr Thr 






      <210> 260
      <211> 1070
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (40)..(1020)

      <400> 260
 gacggtcgga cgccgtatca ttttcttctg tccgggcag   atg aca ccc tgc ccg      54
                                              Met Thr Pro Cys Pro
                                                1               5

 cgc gga gag atg tca tgg cgg cac ctg ctc tcc ctg ata gat gct gag      102
 Arg Gly Glu Met Ser Trp Arg His Leu Leu Ser Leu Ile Asp Ala Glu
                  10                  15                  20

 agc atc cag aaa ctt cca gac cag ccc tct cac cac acc cag aag agg      150
 Ser Ile Gln Lys Leu Pro Asp Gln Pro Ser His His Thr Gln Lys Arg
              25                  30                  35

 cct ttc cca tct gga gag aag ctt cca gac cag ccc ttc aca cac cac      198
 Pro Phe Pro Ser Gly Glu Lys Leu Pro Asp Gln Pro Phe Thr His His
          40                  45                  50

 agc cag gag gcg cct ttc cca cct gga gag aaa ctt cca gac cag ccc      246
 Ser Gln Glu Ala Pro Phe Pro Pro Gly Glu Lys Leu Pro Asp Gln Pro
      55                  60                  65

 ctc ata cca cag cca aga ggg gcc ttt ctc acc tgg aga gaa att tcc      294
 Leu Ile Pro Gln Pro Arg Gly Ala Phe Leu Thr Trp Arg Glu Ile Ser
  70                  75                  80                  85

 aga cca tcc cct ctc acc aca gcc agg aga ggc ctt tcc cac cgg aag      342
 Arg Pro Ser Pro Leu Thr Thr Ala Arg Arg Gly Leu Ser His Arg Lys
                  90                  95                 100

 aga aac ttc cag acc agc ccc tca cac cac agc caa gag aag cct ttc      390
 Arg Asn Phe Gln Thr Ser Pro Ser His His Ser Gln Glu Lys Pro Phe
             105                 110                 115

 cag cct gga gag aaa ctt cca gac cat ccc ctc tca cca cag cca gga      438
 Gln Pro Gly Glu Lys Leu Pro Asp His Pro Leu Ser Pro Gln Pro Gly
         120                 125                 130

 gag gcc ttt ccc ggc ctg gaa act tcc gga caa gcc atc tca cac acc      486
 Glu Ala Phe Pro Gly Leu Glu Thr Ser Gly Gln Ala Ile Ser His Thr
     135                 140                 145

 aca gcc agg aga ggc ctt tcc cac ctg gac aga aac ttc cag cac cag      534
 Thr Ala Arg Arg Gly Leu Ser His Leu Asp Arg Asn Phe Gln His Gln
 150                 155                 160                 165

 ccc ctc tca cca cag cca gga gag gcc ttt acc acc tgg aga gaa gct      582
 Pro Leu Ser Pro Gln Pro Gly Glu Ala Phe Thr Thr Trp Arg Glu Ala
                 170                 175                 180

 tcc aga cca gcc cct cac acc aca gcc agg aga ggc ctt tcc cac ctg      630
 Ser Arg Pro Ala Pro His Thr Thr Ala Arg Arg Gly Leu Ser His Leu
             185                 190                 195

 gag aga aac ttc cag acc agc ccc tca tac cac agc caa gag ggg cct      678
 Glu Arg Asn Phe Gln Thr Ser Pro Ser Tyr His Ser Gln Glu Gly Pro
         200                 205                 210

 ttc tca cct gga gag aaa ctt cca gac cag ccc ctc aca cca ccg aca      726
 Phe Ser Pro Gly Glu Lys Leu Pro Asp Gln Pro Leu Thr Pro Pro Thr
     215                 220                 225

 gga gag gcc ttt ccc acc ggg aga gaa act tcc aga cca gcc cct cac      774
 Gly Glu Ala Phe Pro Thr Gly Arg Glu Thr Ser Arg Pro Ala Pro His
 230                 235                 240                 245

 agc aca gcc agg aga gac cta ttc tgc ctg gag aga aac ttt cag acc      822
 Ser Thr Ala Arg Arg Asp Leu Phe Cys Leu Glu Arg Asn Phe Gln Thr
                 250                 255                 260

 agc ccc aca cac cac agc cag gag agg ccg atc ctg act gga gag aag      870
 Ser Pro Thr His His Ser Gln Glu Arg Pro Ile Leu Thr Gly Glu Lys
             265                 270                 275

 ctt cca gac agc cct tca caa cac agc cag gag agg cct ttc cca cct      918
 Leu Pro Asp Ser Pro Ser Gln His Ser Gln Glu Arg Pro Phe Pro Pro
         280                 285                 290

 gga gag aaa ctt cca gaa cag acc cta ctc acc aca gcc agg aga ggc      966
 Gly Glu Lys Leu Pro Glu Gln Thr Leu Leu Thr Thr Ala Arg Arg Gly
     295                 300                 305

 gta cca cct ggc acc gac aac ttg ctc cct ctg cat gga gca tca cga     1014
 Val Pro Pro Gly Thr Asp Asn Leu Leu Pro Leu His Gly Ala Ser Arg
 310                 315                 320                 325

 gac tga caaccacttc agtaatgaga cacatacccg tgacgaaccc acacctcaca      1070
 Asp 






      <210> 261
      <211> 255
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(255)

      <400> 261
  atg cct ttc gca aag gtt ttc ctt ctt ccc tct cca aaa aag gag aaa      48
  Met Pro Phe Ala Lys Val Phe Leu Leu Pro Ser Pro Lys Lys Glu Lys
    1               5                  10                  15

 agg aaa ccc aaa aaa aaa cgc ctg ggg cag agc ccc cat tcc tac ttc       96
 Arg Lys Pro Lys Lys Lys Arg Leu Gly Gln Ser Pro His Ser Tyr Phe
              20                  25                  30

 aag gat gtg aaa tgc ccg gga tgc tat aaa atc ccc ccg gtt ttt acc      144
 Lys Asp Val Lys Cys Pro Gly Cys Tyr Lys Ile Pro Pro Val Phe Thr
          35                  40                  45

 cat gcc caa acg gta gtt ttg ggt gtt ggg tgg tcc cct gtc ctt tgc      192
 His Ala Gln Thr Val Val Leu Gly Val Gly Trp Ser Pro Val Leu Cys
      50                  55                  60

 ccc ccc cca gga gga aaa aca agg ctt cca aaa gga tgt tcc ttc cgg      240
 Pro Pro Pro Gly Gly Lys Thr Arg Leu Pro Lys Gly Cys Ser Phe Arg
  65                  70                  75                  80

 agg aaa ccg ccc taa                                                  255
 Arg Lys Pro Pro 






      <210> 262
      <211> 447
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(447)

      <400> 262
  atg gtg gcg gcc gcc gcc ccc tcc tcg gcc cta gca tgc ctg cgg ccg      48
  Met Val Ala Ala Ala Ala Pro Ser Ser Ala Leu Ala Cys Leu Arg Pro
    1               5                  10                  15

 cct cgc ggc tac ccg gct tgc cgg tcc cga gcg gca cgc ccg ggg tgg       96
 Pro Arg Gly Tyr Pro Ala Cys Arg Ser Arg Ala Ala Arg Pro Gly Trp
              20                  25                  30

 cga tgg ggt cgc gcc gag gca gcg gag gtt ctg cgg gcg act gga ggt      144
 Arg Trp Gly Arg Ala Glu Ala Ala Glu Val Leu Arg Ala Thr Gly Gly
          35                  40                  45

 tgg cag tgg gcg gga gaa aga gga agg cag gcg cgg ctg ggc ctc tgg      192
 Trp Gln Trp Ala Gly Glu Arg Gly Arg Gln Ala Arg Leu Gly Leu Trp
      50                  55                  60

 ctc tgg cgc cgc ggt acc ctt tgt ctc ggc agc ctg acg gcc ccg ccg      240
 Leu Trp Arg Arg Gly Thr Leu Cys Leu Gly Ser Leu Thr Ala Pro Pro
  65                  70                  75                  80

 ggc tct ccg gag agg gga acg ggc ggc gag ggt ggc ggg tcc tgg gcg      288
 Gly Ser Pro Glu Arg Gly Thr Gly Gly Glu Gly Gly Gly Ser Trp Ala
                  85                  90                  95

 ccc tgt gct gcg ggg ccg aga ggc gct cgg gtc gcg gcg gga tcg gcc      336
 Pro Cys Ala Ala Gly Pro Arg Gly Ala Arg Val Ala Ala Gly Ser Ala
             100                 105                 110

 gga cca gac agg gtt aat gga aga gcc tgg cca gtc ccg cgc ggg gcc      384
 Gly Pro Asp Arg Val Asn Gly Arg Ala Trp Pro Val Pro Arg Gly Ala
         115                 120                 125

 ccc gca gcg aca gcc ttg gcc gcg ggg act gga gtc ctg agg ggg aga      432
 Pro Ala Ala Thr Ala Leu Ala Ala Gly Thr Gly Val Leu Arg Gly Arg
     130                 135                 140

 agc ctg ccg ttc tga                                                  447
 Ser Leu Pro Phe 
 145





      <210> 263
      <211> 1658
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (75)..(1658)

      <400> 263
 cacaatttga acaaatttta ttttaagctt catattttcc tcagcattta aaaaaaaaaa     60

 catgtacaga gacc  atg tcc agg gca gca gct gca gcc gga ccc cca cgc     110
                  Met Ser Arg Ala Ala Ala Ala Ala Gly Pro Pro Arg
                    1               5                  10

 cag gcc acc cct gcc tct ccc cgg tgg tcc aat gac tgt gta ctg cgc      158
 Gln Ala Thr Pro Ala Ser Pro Arg Trp Ser Asn Asp Cys Val Leu Arg
          15                  20                  25

 agg gaa tgc agc aac ccc atc ggg cac act ctt cag cac tac ccg ggg      206
 Arg Glu Cys Ser Asn Pro Ile Gly His Thr Leu Gln His Tyr Pro Gly
      30                  35                  40

 agg tac cag gat cat gta caa ctg gaa att ccc aat aga gtg ctg aac      254
 Arg Tyr Gln Asp His Val Gln Leu Glu Ile Pro Asn Arg Val Leu Asn
  45                  50                  55                  60

 tca cca gtg acc aaa aca ccc tcg agg gac ccg ccc acc act tcc ggg      302
 Ser Pro Val Thr Lys Thr Pro Ser Arg Asp Pro Pro Thr Thr Ser Gly
                  65                  70                  75

 gtc acc agc cct gcc agt gat gag ccc ccg gca gac aca cag aca gcc      350
 Val Thr Ser Pro Ala Ser Asp Glu Pro Pro Ala Asp Thr Gln Thr Ala
              80                  85                  90

 cag aac agc agg cag gtg gtg aag ggt cag agt ttg acc tgg aca tct      398
 Gln Asn Ser Arg Gln Val Val Lys Gly Gln Ser Leu Thr Trp Thr Ser
          95                 100                 105

 aaa ggc cta gcc atg aga agg aaa gga agc aga gac ctg gtg gtt gac      446
 Lys Gly Leu Ala Met Arg Arg Lys Gly Ser Arg Asp Leu Val Val Asp
     110                 115                 120

 agt gcc aag tcc ctg gaa gat ggc cca tct gca gca ctt cac tcg aaa      494
 Ser Ala Lys Ser Leu Glu Asp Gly Pro Ser Ala Ala Leu His Ser Lys
 125                 130                 135                 140

 ctc tat gaa gcc atc atg aga gaa gac tgc act acg atc gag gta ctc      542
 Leu Tyr Glu Ala Ile Met Arg Glu Asp Cys Thr Thr Ile Glu Val Leu
                 145                 150                 155

 ctg aga aat cac cct gtc aac cag ccc atc acc att ctg ccc aac tcc      590
 Leu Arg Asn His Pro Val Asn Gln Pro Ile Thr Ile Leu Pro Asn Ser
             160                 165                 170

 gcc agc aac aga tta ctt ctg acc cag ccg aca gag tct atc atc ccc      638
 Ala Ser Asn Arg Leu Leu Leu Thr Gln Pro Thr Glu Ser Ile Ile Pro
         175                 180                 185

 atc cat ctg gct gcc aag tac cac aag gcc cag agt ctg ctc tgc ctg      686
 Ile His Leu Ala Ala Lys Tyr His Lys Ala Gln Ser Leu Leu Cys Leu
     190                 195                 200

 tta cgg cac ggt gct gac cca gaa gtc agg gac acg aca ggc ctc acc      734
 Leu Arg His Gly Ala Asp Pro Glu Val Arg Asp Thr Thr Gly Leu Thr
 205                 210                 215                 220

 aca ctc aac tta atg cta ctg cac tgg cca gtc act tcc acc acg tgg      782
 Thr Leu Asn Leu Met Leu Leu His Trp Pro Val Thr Ser Thr Thr Trp
                 225                 230                 235

 gca aaa cca ggc aac aga acg cac agg atc ctg aca gac att cag aat      830
 Ala Lys Pro Gly Asn Arg Thr His Arg Ile Leu Thr Asp Ile Gln Asn
             240                 245                 250

 agc agc atc aca tgt ctc cgc atc ttg tgt gcg cac gga gct caa gtg      878
 Ser Ser Ile Thr Cys Leu Arg Ile Leu Cys Ala His Gly Ala Gln Val
         255                 260                 265

 aac act caa ggg gaa atc agc aac aaa cgt tca cca ctc cac ctg gcc      926
 Asn Thr Gln Gly Glu Ile Ser Asn Lys Arg Ser Pro Leu His Leu Ala
     270                 275                 280

 ata gca tat ggt tgc tat cca gtt ctc tcc att ttg acc caa aat ggt      974
 Ile Ala Tyr Gly Cys Tyr Pro Val Leu Ser Ile Leu Thr Gln Asn Gly
 285                 290                 295                 300

 gcc gat gtc aat gct att aat gaa gcc agc atg aca ccc ctt cac atg     1022
 Ala Asp Val Asn Ala Ile Asn Glu Ala Ser Met Thr Pro Leu His Met
                 305                 310                 315

 gcc gca aac atg ctg aat aag gag atg atg gaa acg ctc att gcc tat     1070
 Ala Ala Asn Met Leu Asn Lys Glu Met Met Glu Thr Leu Ile Ala Tyr
             320                 325                 330

 gga gca aac gtc aac tgt gct gtc tct tcc acg ggg aac acg ccc ctg     1118
 Gly Ala Asn Val Asn Cys Ala Val Ser Ser Thr Gly Asn Thr Pro Leu
         335                 340                 345

 aag ctt gca gtg tgc act gca tca agc aaa gca ggc cga ctc ctc ggg     1166
 Lys Leu Ala Val Cys Thr Ala Ser Ser Lys Ala Gly Arg Leu Leu Gly
     350                 355                 360

 gcg ggg gtc agc tgc atc cgt ctg cta ctc act cac gga gcc aaa gtc     1214
 Ala Gly Val Ser Cys Ile Arg Leu Leu Leu Thr His Gly Ala Lys Val
 365                 370                 375                 380

 aac gcc cag gac tac aag ggc caa aca gcc atc cat gag gca tgc ttt     1262
 Asn Ala Gln Asp Tyr Lys Gly Gln Thr Ala Ile His Glu Ala Cys Phe
                 385                 390                 395

 gga ggc aga gag gca atc atc aat ctc ctg ctt gaa ttt gaa gca aat     1310
 Gly Gly Arg Glu Ala Ile Ile Asn Leu Leu Leu Glu Phe Glu Ala Asn
             400                 405                 410

 gtt aac att tta aca aga aac ggg gaa tct cca att tat atg tac ctt     1358
 Val Asn Ile Leu Thr Arg Asn Gly Glu Ser Pro Ile Tyr Met Tyr Leu
         415                 420                 425

 cag cgc agt tgc aat gta aga gat acg gca ctt ctg gcc agg cta ctt     1406
 Gln Arg Ser Cys Asn Val Arg Asp Thr Ala Leu Leu Ala Arg Leu Leu
     430                 435                 440

 tat cac act tat cct ctg aga atg acc aat aac caa gga att cta cct     1454
 Tyr His Thr Tyr Pro Leu Arg Met Thr Asn Asn Gln Gly Ile Leu Pro
 445                 450                 455                 460

 gca gga atc atg cta cca gaa ttc cgc ctc tta agg gac acc cta ata     1502
 Ala Gly Ile Met Leu Pro Glu Phe Arg Leu Leu Arg Asp Thr Leu Ile
                 465                 470                 475

 aag caa tcg caa aaa cct tta tcc cta cag ggt atc tgc aaa aga aac     1550
 Lys Gln Ser Gln Lys Pro Leu Ser Leu Gln Gly Ile Cys Lys Arg Asn
             480                 485                 490

 atc agg aat att tat ggt gag aaa tac aaa cag cac ttg aag caa ttc     1598
 Ile Arg Asn Ile Tyr Gly Glu Lys Tyr Lys Gln His Leu Lys Gln Phe
         495                 500                 505

 ctc cca gtg aca ata tgg aat tct gtc tac tgc tgt tat gac ttg gca     1646
 Leu Pro Val Thr Ile Trp Asn Ser Val Tyr Cys Cys Tyr Asp Leu Ala
     510                 515                 520

 tat acc tct tga                                                     1658
 Tyr Thr Ser 
 525





      <210> 264
      <211> 803
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (66)..(629)

      <400> 264
 gcagcccgga ggccctggat ggcatcgtgg gcacgctggg tgcccaggcc ctggccctgc     60

 gcaga    atg cag gac gag cct tac cag gcg ctg gta gcc gag cta cac     107
          Met Gln Asp Glu Pro Tyr Gln Ala Leu Val Ala Glu Leu His
            1               5                  10

 cgg cgg gcg ctg gtc gag tac gtg cgg ccc ctg ctc cgt ggg cgc ctg      155
 Arg Arg Ala Leu Val Glu Tyr Val Arg Pro Leu Leu Arg Gly Arg Leu
  15                  20                  25                  30

 cgc tgc agc tcg gcg cgg acc cgc agc cgc gtg gcc ggc agg ctc cgg      203
 Arg Cys Ser Ser Ala Arg Thr Arg Ser Arg Val Ala Gly Arg Leu Arg
                  35                  40                  45

 gag gac gcg gcg cac tgc aga ggc tgt tcc ggc ggc tgg agt ccc agg      251
 Glu Asp Ala Ala His Cys Arg Gly Cys Ser Gly Gly Trp Ser Pro Arg
              50                  55                  60

 cct cgt ggc tgg atg ccg tgg tgc ccc att tgg ctg aag tca tgc agc      299
 Pro Arg Gly Trp Met Pro Trp Cys Pro Ile Trp Leu Lys Ser Cys Ser
          65                  70                  75

 tgg aag aca cgc cca gca tcc agg tgg agg tgg gag tgt tgg tgc gcg      347
 Trp Lys Thr Arg Pro Ala Ser Arg Trp Arg Trp Glu Cys Trp Cys Ala
      80                  85                  90

 act acc cag aca tca ggc aga agc acg tgg cag ccc tcc tcg aca tcc      395
 Thr Thr Gln Thr Ser Gly Arg Ser Thr Trp Gln Pro Ser Ser Thr Ser
  95                 100                 105                 110

 gtg gcc tgc gca aca cag ccg ccc gcc agg aga tcc tgg ccg tgg ccc      443
 Val Ala Cys Ala Thr Gln Pro Pro Ala Arg Arg Ser Trp Pro Trp Pro
                 115                 120                 125

 ggg acc tgg aac tct ctg agg agg gag ccc tgt cac ccc ctc ggg acc      491
 Gly Thr Trp Asn Ser Leu Arg Arg Glu Pro Cys His Pro Leu Gly Thr
             130                 135                 140

 gtg cct tct ttg cag aca tcc ctg tgc ccc gcc cat ctt tct gtc tca      539
 Val Pro Ser Leu Gln Thr Ser Leu Cys Pro Ala His Leu Ser Val Ser
         145                 150                 155

 gcc tcc ctc tct tcc tgg gcc gcc tcc ccc tct ccc ggc tgg cca ggc      587
 Ala Ser Leu Ser Ser Trp Ala Ala Ser Pro Ser Pro Gly Trp Pro Gly
     160                 165                 170

 cca gtt tgg cct gtc tgc ctc ggc ccc ggc ctc cgt ctc tag cgcgacc      636
 Pro Val Trp Pro Val Cys Leu Gly Pro Gly Leu Arg Leu 
 175                 180                 185

 tcgggcccag cgctgagggt cacccaaccg ccggccttag tgaccccatc tatgctgctg    696

 acaagccaac ctcccgtacg gcgcccctcc tgactccctg cctgggacca cacacccctg    756

 ggatagaaag acccttagat gtcttttcac ccaaccccaa actccct                  803




      <210> 265
      <211> 1082
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (346)..(1035)

      <400> 265
 ctagcagcga gtcccttggg atgcttggtt gtcgtcccca tgtttagcaa ggatctgtac     60

 tagatgcaga aacttttcta agtctagcga gagcccactt attttccctt tcagattccc    120

 acctcccttt tcctcaagaa aggtcagtag gggaattttc accaattcta ccactcccca    180

 ataactgcgc tcagccactc ttaggatttg gcgggtggac aggcgaaact gcggatccca    240

 ggatgcagtt ccccccttca tcacctgtgt agcccggtcg ctaccctcac tgcattctgg    300

 gaaatgtagt ttcttatcag taacgacaac gtctcgaggg ctccc    atg gat agc     354
                                                      Met Asp Ser
                                                        1

 ctt gac aga tcc tgc cag gac tgg tgc gac agg aag caa cac tgg ttg      402
 Leu Asp Arg Ser Cys Gln Asp Trp Cys Asp Arg Lys Gln His Trp Leu
       5                  10                  15

 gag atc gga cca ccg gac ttg gtg gag cgc aag ggc tcc ctg acc ctc      450
 Glu Ile Gly Pro Pro Asp Leu Val Glu Arg Lys Gly Ser Leu Thr Leu
  20                  25                  30                  35

 cgc tcc cat cac aag aaa tac tcg aag ccg gtg ttg gtg tat tcc tgg      498
 Arg Ser His His Lys Lys Tyr Ser Lys Pro Val Leu Val Tyr Ser Trp
                  40                  45                  50

 cac cgt gac aga gaa gct ttt ccc aaa ggt tat gat ata gag ggt cct      546
 His Arg Asp Arg Glu Ala Phe Pro Lys Gly Tyr Asp Ile Glu Gly Pro
              55                  60                  65

 gag aaa gtt aaa aaa ctg tgt aat tca aca tat cgg cga ctg gga acc      594
 Glu Lys Val Lys Lys Leu Cys Asn Ser Thr Tyr Arg Arg Leu Gly Thr
          70                  75                  80

 gat gaa tcc cca att tgg aca tca gaa aca cat gaa aag ttg tca caa      642
 Asp Glu Ser Pro Ile Trp Thr Ser Glu Thr His Glu Lys Leu Ser Gln
      85                  90                  95

 atg tgt tta aac aca gaa tgg gtt gaa atg aag agc aag gct tta ttg      690
 Met Cys Leu Asn Thr Glu Trp Val Glu Met Lys Ser Lys Ala Leu Leu
 100                 105                 110                 115

 aat gag gaa aca gtg agc tcc ggg att atc gaa agg gtc acc gga ttg      738
 Asn Glu Glu Thr Val Ser Ser Gly Ile Ile Glu Arg Val Thr Gly Leu
                 120                 125                 130

 cct gcc aca ggt ttt gga gct gtc ttt cct aga cat cca ccg gat tgg      786
 Pro Ala Thr Gly Phe Gly Ala Val Phe Pro Arg His Pro Pro Asp Trp
             135                 140                 145

 agc aaa atg tgt gca ttg aca acg tac tca gaa gat tat gtt cca cca      834
 Ser Lys Met Cys Ala Leu Thr Thr Tyr Ser Glu Asp Tyr Val Pro Pro
         150                 155                 160

 tat gat tat cag cca cat gct tat ccc tgt caa gat gat tat tcc ata      882
 Tyr Asp Tyr Gln Pro His Ala Tyr Pro Cys Gln Asp Asp Tyr Ser Ile
     165                 170                 175

 gtc cac aga aaa tgc cgt tct cag ttc acg gat cta aat ggt tct aaa      930
 Val His Arg Lys Cys Arg Ser Gln Phe Thr Asp Leu Asn Gly Ser Lys
 180                 185                 190                 195

 aga ttt ggc atc aac act tgg cat gat gag agt ggg att tat gct aat      978
 Arg Phe Gly Ile Asn Thr Trp His Asp Glu Ser Gly Ile Tyr Ala Asn
                 200                 205                 210

 tca gat gta aaa cag aaa ctc tat ccc ttg act agt ggg cct att gtg     1026
 Ser Asp Val Lys Gln Lys Leu Tyr Pro Leu Thr Ser Gly Pro Ile Val
             215                 220                 225

 cca att taa aaataat gtatagaatc agcatctctg actaatgaaa aatggatgta     1082
 Pro Ile 






      <210> 266
      <211> 888
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(888)

      <400> 266
  atg gac gac aag gag tta att gaa tac ttt aag tct cag atg aaa gaa      48
  Met Asp Asp Lys Glu Leu Ile Glu Tyr Phe Lys Ser Gln Met Lys Glu
    1               5                  10                  15

 gat cct gac atg gcc tca gca gtg gct gcc atc cgg acg ttg ctg gag       96
 Asp Pro Asp Met Ala Ser Ala Val Ala Ala Ile Arg Thr Leu Leu Glu
              20                  25                  30

 ttc ttg aag aga gat aaa ggg gag aca atc cag ggt ctg agg gcg aat      144
 Phe Leu Lys Arg Asp Lys Gly Glu Thr Ile Gln Gly Leu Arg Ala Asn
          35                  40                  45

 ctc acc agt gcc ata gaa acc ctg tgt ggt gtg gac tcc tct gtg gca      192
 Leu Thr Ser Ala Ile Glu Thr Leu Cys Gly Val Asp Ser Ser Val Ala
      50                  55                  60

 gtg tcc tct ggc ggg gag ctc ttc ctc cgc ttc atc agt ctt gcc tcc      240
 Val Ser Ser Gly Gly Glu Leu Phe Leu Arg Phe Ile Ser Leu Ala Ser
  65                  70                  75                  80

 ctg gaa tac tcc gat tac tcc aaa tgt aaa aag atc atg att gag cgg      288
 Leu Glu Tyr Ser Asp Tyr Ser Lys Cys Lys Lys Ile Met Ile Glu Arg
                  85                  90                  95

 gga gaa ctt ttt ctc agg aga ata tca ctg tca aga aac aaa att gca      336
 Gly Glu Leu Phe Leu Arg Arg Ile Ser Leu Ser Arg Asn Lys Ile Ala
             100                 105                 110

 gat ctg tgc cat act ttc atc aaa gat gga gcg aca ata ttg act cac      384
 Asp Leu Cys His Thr Phe Ile Lys Asp Gly Ala Thr Ile Leu Thr His
         115                 120                 125

 gcc tac tcc aga gtg gtc ctg aga gtc ctg gaa gca gcc gtg gcg gcc      432
 Ala Tyr Ser Arg Val Val Leu Arg Val Leu Glu Ala Ala Val Ala Ala
     130                 135                 140

 aag aag cga ttt agt gta tac gtc aca gag tca cag cct gat ttt aag      480
 Lys Lys Arg Phe Ser Val Tyr Val Thr Glu Ser Gln Pro Asp Phe Lys
 145                 150                 155                 160

 aaa atg gcc aaa gcc ctc tgc cac ctc aac gtc cct gtc act gtg gtg      528
 Lys Met Ala Lys Ala Leu Cys His Leu Asn Val Pro Val Thr Val Val
                 165                 170                 175

 cta gat gct gct gtc ggc tac atc atg gag aaa gca gat ctt gtc ata      576
 Leu Asp Ala Ala Val Gly Tyr Ile Met Glu Lys Ala Asp Leu Val Ile
             180                 185                 190

 gtt ggt gct gaa gga gtt gtt gaa aac gga gga att att aac aag aga      624
 Val Gly Ala Glu Gly Val Val Glu Asn Gly Gly Ile Ile Asn Lys Arg
         195                 200                 205

 gca gtc tca gga agt agc aca ctg atc act cac acc aag gcc cta cca      672
 Ala Val Ser Gly Ser Ser Thr Leu Ile Thr His Thr Lys Ala Leu Pro
     210                 215                 220

 ggt cag agc act aaa tat tca gtg ccg act aat gtg tac ttc tct cct      720
 Gly Gln Ser Thr Lys Tyr Ser Val Pro Thr Asn Val Tyr Phe Ser Pro
 225                 230                 235                 240

 cag tat aag gca gac act ctc aag gtc gcg cag act gga caa gac ctc      768
 Gln Tyr Lys Ala Asp Thr Leu Lys Val Ala Gln Thr Gly Gln Asp Leu
                 245                 250                 255

 aaa gag gag cat ccg tgg gtc gac tac act gcc cct tcc tta atc act      816
 Lys Glu Glu His Pro Trp Val Asp Tyr Thr Ala Pro Ser Leu Ile Thr
             260                 265                 270

 ctg ctg ttt aca gac ctg ggc gtg ctg aca ccc tca gca gtc agc gat      864
 Leu Leu Phe Thr Asp Leu Gly Val Leu Thr Pro Ser Ala Val Ser Asp
         275                 280                 285

 gag ctc atc aag ctc tat ctg taa                                      888
 Glu Leu Ile Lys Leu Tyr Leu 
     290                 295





      <210> 267
      <211> 1799
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (302)..(1729)

      <400> 267
 ccacatcacc atcctggtgg aactctcctg tgaggacagc caaggcctga actacctgcg     60

 ggtttgccca ggcaaccagc cagccctggt ccaaggcatc ctggagcgag ttgtggatgg    120

 ccccgtgccc caccagacag tgcgcctgga ggacctggac gagagcggtg agccccaggc    180

 tggggagcca gtgctgcctg gcatcctccg gccaccctac ctggctgagg ggctgggcct    240

 gggcctgccg gtccctggag ctcccggtcc ctggagctct gcacttgggg gcacaacttg    300

 c    atg agg cag cgc gac tct ggc gac tgg ctg gcc atg ccg tcc cgg     346
      Met Arg Gln Arg Asp Ser Gly Asp Trp Leu Ala Met Pro Ser Arg
        1               5                  10                  15

 gct gag aac tat gaa gtg ttg tac acc att ggc aca ggc tcc tct ggc      394
 Ala Glu Asn Tyr Glu Val Leu Tyr Thr Ile Gly Thr Gly Ser Ser Gly
                  20                  25                  30

 cgc tgc cag aag atc cag agg aag agt gac ggc aag ata cta gtt tgg      442
 Arg Cys Gln Lys Ile Gln Arg Lys Ser Asp Gly Lys Ile Leu Val Trp
              35                  40                  45

 aaa gaa ctt gat tat ggc ttc atg aca gaa gct gag aaa cag atg ctt      490
 Lys Glu Leu Asp Tyr Gly Phe Met Thr Glu Ala Glu Lys Gln Met Leu
          50                  55                  60

 att tct gaa gtg aat ttg ctt tgt aaa ctg aaa aat cca aac atc gtt      538
 Ile Ser Glu Val Asn Leu Leu Cys Lys Leu Lys Asn Pro Asn Ile Val
      65                  70                  75

 cat tac tat gat cgt att att gac cgg acc aac aca aca ctg tac att      586
 His Tyr Tyr Asp Arg Ile Ile Asp Arg Thr Asn Thr Thr Leu Tyr Ile
  80                  85                  90                  95

 gta atg gaa tat tgt gaa gaa gga gac ctg gct agt gta att aca aag      634
 Val Met Glu Tyr Cys Glu Glu Gly Asp Leu Ala Ser Val Ile Thr Lys
                 100                 105                 110

 gga acc aag gaa agg caa tac tta gat gaa gag ttt gtt ctt cga gtg      682
 Gly Thr Lys Glu Arg Gln Tyr Leu Asp Glu Glu Phe Val Leu Arg Val
             115                 120                 125

 acg act cag ttg act ctg gcc ctg aaa cga agt ggt ggt gat cat act      730
 Thr Thr Gln Leu Thr Leu Ala Leu Lys Arg Ser Gly Gly Asp His Thr
         130                 135                 140

 gta gtg cgt cgg gat ctg aaa cca gcc agt gtt ttc ctg gat ggc aag      778
 Val Val Arg Arg Asp Leu Lys Pro Ala Ser Val Phe Leu Asp Gly Lys
     145                 150                 155

 caa aac gtc aag ctt gga gat ttg ggg cta gcc aga ata tta aac cac      826
 Gln Asn Val Lys Leu Gly Asp Leu Gly Leu Ala Arg Ile Leu Asn His
 160                 165                 170                 175

 gac acg agt ttt gca aaa aca ttt gtt ggc aca cct tat tac atg tct      874
 Asp Thr Ser Phe Ala Lys Thr Phe Val Gly Thr Pro Tyr Tyr Met Ser
                 180                 185                 190

 cct gaa caa acg aat cac atg tcc tac aat gag aaa cca gat atc tgg      922
 Pro Glu Gln Thr Asn His Met Ser Tyr Asn Glu Lys Pro Asp Ile Trp
             195                 200                 205

 tca ttg ggc cgc ttg ctg tat gag tta ggt gca tta atg cct cca ttt      970
 Ser Leu Gly Arg Leu Leu Tyr Glu Leu Gly Ala Leu Met Pro Pro Phe
         210                 215                 220

 aca gct ttt agc cag aaa gaa ctt gct ggg aaa atc aga gaa ggc aaa     1018
 Thr Ala Phe Ser Gln Lys Glu Leu Ala Gly Lys Ile Arg Glu Gly Lys
     225                 230                 235

 ttc agg caa att cta tac cat tac tct gat gaa ttg aat gaa att att     1066
 Phe Arg Gln Ile Leu Tyr His Tyr Ser Asp Glu Leu Asn Glu Ile Ile
 240                 245                 250                 255

 atg agg atg tta aag gat tac cat cga cct tct gtt gaa gaa att ctc     1114
 Met Arg Met Leu Lys Asp Tyr His Arg Pro Ser Val Glu Glu Ile Leu
                 260                 265                 270

 gag aac cct tta ata gca gat ttg gtt gca gaa gag caa aga aga aat     1162
 Glu Asn Pro Leu Ile Ala Asp Leu Val Ala Glu Glu Gln Arg Arg Asn
             275                 280                 285

 ctt gag aga aga ggg cga caa tta gga gag cca gaa aaa ttg ccg gat     1210
 Leu Glu Arg Arg Gly Arg Gln Leu Gly Glu Pro Glu Lys Leu Pro Asp
         290                 295                 300

 tcc agc ctt gta ttg agt gag ctg aaa cta aag gaa att cag tta gag     1258
 Ser Ser Leu Val Leu Ser Glu Leu Lys Leu Lys Glu Ile Gln Leu Glu
     305                 310                 315

 gag caa gag cga gct ctc aaa gca gga gaa gaa agg ttg gag cag aaa     1306
 Glu Gln Glu Arg Ala Leu Lys Ala Gly Glu Glu Arg Leu Glu Gln Lys
 320                 325                 330                 335

 gaa cag gag ctt tgt gtt tgt gag aga cta gca gag gac aga ctg gct     1354
 Glu Gln Glu Leu Cys Val Cys Glu Arg Leu Ala Glu Asp Arg Leu Ala
                 340                 345                 350

 ata cca gaa aat ctg ttg aag aat tac agc ttg cta aag gaa cag aag     1402
 Ile Pro Glu Asn Leu Leu Lys Asn Tyr Ser Leu Leu Lys Glu Gln Lys
             355                 360                 365

 ttc ctg tct ctg gca agt agt cca gaa ctt ctt aat ctt cca tcc tca     1450
 Phe Leu Ser Leu Ala Ser Ser Pro Glu Leu Leu Asn Leu Pro Ser Ser
         370                 375                 380

 gta att aag aag aaa gtt cat ttc agt ggg gaa agt aaa gag aat gtc     1498
 Val Ile Lys Lys Lys Val His Phe Ser Gly Glu Ser Lys Glu Asn Val
     385                 390                 395

 atg agg agt gag aat tct gag agt cag ctc aca tct aag tcc aag tgc     1546
 Met Arg Ser Glu Asn Ser Glu Ser Gln Leu Thr Ser Lys Ser Lys Cys
 400                 405                 410                 415

 aag gac ctg aag gtc cct tgc ttc atg ctt cat gct gcc cag ctg cgg     1594
 Lys Asp Leu Lys Val Pro Cys Phe Met Leu His Ala Ala Gln Leu Arg
                 420                 425                 430

 gct caa gcc ctg tca gat ttt gag aaa aat tat caa cta att tct gag     1642
 Ala Gln Ala Leu Ser Asp Phe Glu Lys Asn Tyr Gln Leu Ile Ser Glu
             435                 440                 445

 tta caa gta tgt gaa aga cac atg tat aca tgt aat gaa atg tat agt     1690
 Leu Gln Val Cys Glu Arg His Met Tyr Thr Cys Asn Glu Met Tyr Ser
         450                 455                 460

 ttt cct ttt att tct gta aag caa gtt agc ttg tat tga tacatgatga      1739
 Phe Pro Phe Ile Ser Val Lys Gln Val Ser Leu Tyr 
     465                 470                 475

 gtttttttca gaggtttcag aaacaggtta gaaaatgctt ccatagtatt tcatagattc   1799




      <210> 268
      <211> 2828
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (6)..(1016)

      <400> 268
 aaatt    atg cta ggt acg agg ccg gcg gtg tta aat cgg ccg agg cgg      47
          Met Leu Gly Thr Arg Pro Ala Val Leu Asn Arg Pro Arg Arg
            1               5                  10

 aac cgg ctc gcg agc gca gct atg gct gct ggc gta ccc tgt gcg tta       95
 Asn Arg Leu Ala Ser Ala Ala Met Ala Ala Gly Val Pro Cys Ala Leu
  15                  20                  25                  30

 gtc acc agc tgc tcc tcc gtc ttc tca gga gac cag ctg gtc caa cat      143
 Val Thr Ser Cys Ser Ser Val Phe Ser Gly Asp Gln Leu Val Gln His
                  35                  40                  45

 atc ctt gga aca gaa gat ctt att gtg gaa gtg act tcc aat gat gct      191
 Ile Leu Gly Thr Glu Asp Leu Ile Val Glu Val Thr Ser Asn Asp Ala
              50                  55                  60

 gtg aga ttt tat ccc tgg acc att gat aat aaa tac tat tca gca gac      239
 Val Arg Phe Tyr Pro Trp Thr Ile Asp Asn Lys Tyr Tyr Ser Ala Asp
          65                  70                  75

 atc aat cta tgt gtg gtg cca aac aaa ttt ctt gtt act gca gag att      287
 Ile Asn Leu Cys Val Val Pro Asn Lys Phe Leu Val Thr Ala Glu Ile
      80                  85                  90

 gca gaa tct gtc caa gca ttt gtg gtt tac ttt gac agc aca caa aaa      335
 Ala Glu Ser Val Gln Ala Phe Val Val Tyr Phe Asp Ser Thr Gln Lys
  95                 100                 105                 110

 tcg ggc ctt gat agt gtc tcc tca tgg ctt cca ctg gca aaa gca tgg      383
 Ser Gly Leu Asp Ser Val Ser Ser Trp Leu Pro Leu Ala Lys Ala Trp
                 115                 120                 125

 tta cct gag gtg atg atc ttg gtc tgc gat aga gtg tct gaa gat ggt      431
 Leu Pro Glu Val Met Ile Leu Val Cys Asp Arg Val Ser Glu Asp Gly
             130                 135                 140

 ata aac cga caa aaa gct caa gaa tgg tgc ctc aaa cat ggc ttt gaa      479
 Ile Asn Arg Gln Lys Ala Gln Glu Trp Cys Leu Lys His Gly Phe Glu
         145                 150                 155

 ttg gta gaa ctt agt cca gag gag ttg cct gag gag gat gat gac ttc      527
 Leu Val Glu Leu Ser Pro Glu Glu Leu Pro Glu Glu Asp Asp Asp Phe
     160                 165                 170

 cca gaa tct aca gga gta aag cga att gtc caa gcc ctg aat gcc aat      575
 Pro Glu Ser Thr Gly Val Lys Arg Ile Val Gln Ala Leu Asn Ala Asn
 175                 180                 185                 190

 gtg tgg tcc aat gta gtg atg aag aat gat agg aac caa ggc ttt agc      623
 Val Trp Ser Asn Val Val Met Lys Asn Asp Arg Asn Gln Gly Phe Ser
                 195                 200                 205

 ctt ctc aac tca ttg act gga aca aac cat agc att ggg tca gca gat      671
 Leu Leu Asn Ser Leu Thr Gly Thr Asn His Ser Ile Gly Ser Ala Asp
             210                 215                 220

 ccc tgt cac cca gag caa ccc cat ttg cca gca gca gat agt act gaa      719
 Pro Cys His Pro Glu Gln Pro His Leu Pro Ala Ala Asp Ser Thr Glu
         225                 230                 235

 tcc ctc tct gat cat cgg ggt ggt gca tct aac aca aca gat gcc cag      767
 Ser Leu Ser Asp His Arg Gly Gly Ala Ser Asn Thr Thr Asp Ala Gln
     240                 245                 250

 gtt gat agc att gtg gat ccc atg tta gat ctg gat att caa gaa tta      815
 Val Asp Ser Ile Val Asp Pro Met Leu Asp Leu Asp Ile Gln Glu Leu
 255                 260                 265                 270

 gcc agt ctt acc act gga gga gga gat gtg gag aat ttt gaa aga ctc      863
 Ala Ser Leu Thr Thr Gly Gly Gly Asp Val Glu Asn Phe Glu Arg Leu
                 275                 280                 285

 ttt tca aag tta aag gaa atg aaa gac aag gct gcg acg ctt cct cat      911
 Phe Ser Lys Leu Lys Glu Met Lys Asp Lys Ala Ala Thr Leu Pro His
             290                 295                 300

 gag caa aga aaa gtg cat gca gaa aag gtg gcc aaa gca ttc tgg atg      959
 Glu Gln Arg Lys Val His Ala Glu Lys Val Ala Lys Ala Phe Trp Met
         305                 310                 315

 gca atc ggg gga gac aga gat gaa att gaa ggc ctt tca tct gat gaa     1007
 Ala Ile Gly Gly Asp Arg Asp Glu Ile Glu Gly Leu Ser Ser Asp Glu
     320                 325                 330

 gag cac tga attattc atactagggt ttgaccaaca aagatgctag ctgtctctga     1063
 Glu His 
 335

 gatacctctc tactcagccc agtcatattt tgccaaaatt gcccttatca tgttggctgc   1123

 ctgacttgtt tatagggtcc ccttaatttt agtttttagt aggaggttaa ggagaaatct   1183

 tttttttcct cagtatattg taagagagtg aggaatacag tgatagtaat gagtgaggat   1243

 ttcttaaata tacttttttt tttgttctag gaatgagggt aggataaatc tcagaggtct   1303

 gtgtgattta ctcaagttga agacaacctc caggccattc ctggtcaacc ttttaagtag   1363

 catttccagc attcacactt gatactgcac atcaggagtt gtgtcacctt tcctgggtga   1423

 tttgggtttt ctccattcaa ggagcttgta gctctgagct atgatgcttt tattgggagg   1483

 aaaggaggca gctgcagaat tgatgtgagc tatgtggggc cgaagtctca gcccgcagct   1543

 aagtctctac ctaagaaaat gcctctgggc attcttttga agtatagtgt ctgagctcat   1603

 gctagaaaga atcaaaaagc cagtgtggat ttttagactg taataaatga ggcaaaggat   1663

 ttctattcca gtgggaagga aacctctcta ctgagttgtg ggggatatgt tgtatgttag   1723

 aaagaacctt aaggagtcct tgtatgggcc atggagacag tatgtgataa cataccgtga   1783

 ttttcatgaa gaaattcttc tgtcttagag ttctcccctg ctgcttgaga tgccagagct   1843

 gtgttgttgc acacctgcaa aacaaggcac atttccccct ttctctttaa agccaaagag   1903

 agatcactgc caaagtggga gcactaaggg gtgggtgggg aagtgaaatg ttaggcgata   1963

 aattcctgag caccttgttt ttcttccaag gttcgtagct cctctctgcc cttccaagcc   2023

 tgtaacctcg gaggactatc ttttgttctt tatcctttgt cttgtttgag tgggtcagcc   2083

 ccagaggaac tgataagcaa atggcaagtt tttaaaggaa gagtggaaag tactgcaaat   2143

 aaaaatcctt atttgttttt gtagactttg taatgcatat cattagccct cactgtgatc   2203

 attactgctg tggctctgaa ctggcacata gtacagtgga tggaaggtgc ccgcacacca   2263

 gctgagaact ggttctggcc taggtgggct ctagaaccat ttacacagca tgaaagaaac   2323

 aggttgggtt aggagcagaa agaaataagg ctcacacccc tccagacact accttataag   2383

 cactgcagaa cctgaaacag atggcagaag gaatggaatg ctacaggggc cagcaggagt   2443

 gaccacaggg aggggacagc tcagtgactg gagcattcag gaagaggctt tccagggaac   2503

 actggacatt gcttagtgac cttttgttcc tttttttttt tttttctttt actgttctga   2563

 aagactttga gtctgtggtt caccaccagc ccatcagtgt ttctttgagg tgattgcatt   2623

 agggaagttg gctctgggat tgcaaaaaaa aaaaaaaggt ggaacatgtt ttccttaaaa   2683

 gatggaaggt tttagaaaat atactaggcc atctggttag aaaaaacaga ccagactaga   2743

 aaaagctgtg aatttgattt tgtagattaa acaaagccag atgattaaaa tgtgatttat   2803

 ttataaaaaa aaaaaaaaaa aaaaa                                         2828




      <210> 269
      <211> 850
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (149)..(727)

      <400> 269
 tctcctgcta ccactcactt tcttaaagcg ttttcagttt gctcctaatt cttcaggatt     60

 gatcatcatt gtaaaagaaa acactgctgt gagccagaca caaaaacatc catttctcta    120

 aggattcact tagctttgtc atggcaac   atg agt gaa gta aaa cat gct tta     172
                                  Met Ser Glu Val Lys His Ala Leu
                                    1               5

 act atg cgt ggg att cca cgg caa cgg gcc gcc ctc ctc cag ccc agg      220
 Thr Met Arg Gly Ile Pro Arg Gln Arg Ala Ala Leu Leu Gln Pro Arg
      10                  15                  20

 cat gag aac agc ctc ctt ggc aag gaa gcc gtc tca gtt tcc tat ggc      268
 His Glu Asn Ser Leu Leu Gly Lys Glu Ala Val Ser Val Ser Tyr Gly
  25                  30                  35                  40

 tgt tgt aac aaa gta cga aaa act gag tgg ctt ggg aca gca gaa att      316
 Cys Cys Asn Lys Val Arg Lys Thr Glu Trp Leu Gly Thr Ala Glu Ile
                  45                  50                  55

 tat tgt ctc agt tct gag ggc cac cat ctg aaa tca agg tgt cag tgg      364
 Tyr Cys Leu Ser Ser Glu Gly His His Leu Lys Ser Arg Cys Gln Trp
              60                  65                  70

 ggc cat gct ccc tat gaa ggc aca aag aca agg gac gac cat cgt cat      412
 Gly His Ala Pro Tyr Glu Gly Thr Lys Thr Arg Asp Asp His Arg His
          75                  80                  85

 ctg aac cag ttc ata gct cat gct gct ctc gac ctc gta gat gag aac      460
 Leu Asn Gln Phe Ile Ala His Ala Ala Leu Asp Leu Val Asp Glu Asn
      90                  95                 100

 atg tgg ctg tcg aac aac atg tac ttg aaa act gtg gac aag ttc aac      508
 Met Trp Leu Ser Asn Asn Met Tyr Leu Lys Thr Val Asp Lys Phe Asn
 105                 110                 115                 120

 gag tgg ttt gtg tca gca ttt gtc acc gcg ggg cat atg agg ttt att      556
 Glu Trp Phe Val Ser Ala Phe Val Thr Ala Gly His Met Arg Phe Ile
                 125                 130                 135

 atg ctt cat gac ata aga caa gaa gat gga ata aag aac ttc ttt act      604
 Met Leu His Asp Ile Arg Gln Glu Asp Gly Ile Lys Asn Phe Phe Thr
             140                 145                 150

 gat gtt tat gat tta tat ata aaa ttt tca atg aat cca ttt tat gaa      652
 Asp Val Tyr Asp Leu Tyr Ile Lys Phe Ser Met Asn Pro Phe Tyr Glu
         155                 160                 165

 ccc aat tct cct att cga tca agt gca ttt gac aga aaa gtt cag ttt      700
 Pro Asn Ser Pro Ile Arg Ser Ser Ala Phe Asp Arg Lys Val Gln Phe
     170                 175                 180

 ctt ggg aag aaa cac ctt tta agc tga atgga gaaaattcca aaataaatta      752
 Leu Gly Lys Lys His Leu Leu Ser 
 185                 190

 tatcaccaca atggtgtata ctcaggaatg tgtacattgt aaattacttg attaaatagc    812

 ctggaaatct ttaaaaaaaa aaaaaaaaaa aaagagct                            850




      <210> 270
      <211> 2101
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (247)..(1584)

      <400> 270
 atgagggtga aaaaaaaaaa gcaccttgaa gctggcagaa cagccccacg catctgtgcc     60

 gtgcttcctg ccccccctgc tgctgtgaag tgcctgtggt ggatgtggga tgcttccaag    120

 ccagctggtg tggcctcttc cacccacggg gataactggg gtgtgccgat cggccaccca    180

 gccagagcac ctggactcaa acttcaaaga cagagactta agatgttgac cctcaggtca    240

 gagaca   atg acc atg ttt gaa aat gtc acc cgg gcc ctg gcc aga cag     288
          Met Thr Met Phe Glu Asn Val Thr Arg Ala Leu Ala Arg Gln
            1               5                  10

 cta aac cct cga ggg gac ctg aca cca ctt gac agc ctc atc gac ttc      336
 Leu Asn Pro Arg Gly Asp Leu Thr Pro Leu Asp Ser Leu Ile Asp Phe
  15                  20                  25                  30

 aag cgc ttc cat ccc ttc tgc ctg gtg ctg agg aag agg aag agc acg      384
 Lys Arg Phe His Pro Phe Cys Leu Val Leu Arg Lys Arg Lys Ser Thr
                  35                  40                  45

 ctc ttc tgg ggg gcc cgg tac gtc cgc acc gac tac acg ctg ctg gat      432
 Leu Phe Trp Gly Ala Arg Tyr Val Arg Thr Asp Tyr Thr Leu Leu Asp
              50                  55                  60

 gtg ctt gag ccc ggc agc tca cct tca gac cca aca gac act ggg aat      480
 Val Leu Glu Pro Gly Ser Ser Pro Ser Asp Pro Thr Asp Thr Gly Asn
          65                  70                  75

 ttt ggc ttt aag aat atg ctg gac acc cga gtg gag gga gat gtg gat      528
 Phe Gly Phe Lys Asn Met Leu Asp Thr Arg Val Glu Gly Asp Val Asp
      80                  85                  90

 gta cca aag acg gtg aag gtg aag gga acg gca ggg ctc tcg cag aac      576
 Val Pro Lys Thr Val Lys Val Lys Gly Thr Ala Gly Leu Ser Gln Asn
  95                 100                 105                 110

 agc act ctg gag gtc cag aca ctc agt gtg gct ccc aag gcc ctg gag      624
 Ser Thr Leu Glu Val Gln Thr Leu Ser Val Ala Pro Lys Ala Leu Glu
                 115                 120                 125

 acc ttg cag aag agg aag ctg gca gca gac cac cca ttc ctg aag gag      672
 Thr Leu Gln Lys Arg Lys Leu Ala Ala Asp His Pro Phe Leu Lys Glu
             130                 135                 140

 atg caa gat caa ggg gag aac ctg tat gtg gtg atg gag gtg gtg gag      720
 Met Gln Asp Gln Gly Glu Asn Leu Tyr Val Val Met Glu Val Val Glu
         145                 150                 155

 acg gtg cag gag gtc aca ctg gag cga gcc ggc aag gca gag gcc tgc      768
 Thr Val Gln Glu Val Thr Leu Glu Arg Ala Gly Lys Ala Glu Ala Cys
     160                 165                 170

 ttc tcc ctc ccc ttc ttc gcc cca ttg ggg cta cag gga tcc ata aat      816
 Phe Ser Leu Pro Phe Phe Ala Pro Leu Gly Leu Gln Gly Ser Ile Asn
 175                 180                 185                 190

 cac aag gag gct gta acc atc ccc aag ggc tgc gtc ctg gcc ttt cga      864
 His Lys Glu Ala Val Thr Ile Pro Lys Gly Cys Val Leu Ala Phe Arg
                 195                 200                 205

 gtg aga cag ctg atg gtc aaa ggc aaa gat gag tgg gat att cca cat      912
 Val Arg Gln Leu Met Val Lys Gly Lys Asp Glu Trp Asp Ile Pro His
             210                 215                 220

 atc tgc aat gat aac atg caa acc ttc cct cct gga gaa aag tca gga      960
 Ile Cys Asn Asp Asn Met Gln Thr Phe Pro Pro Gly Glu Lys Ser Gly
         225                 230                 235

 gag gag aag gtc atc ctt atc cag gca tct gat gtt ggg gac gta cac     1008
 Glu Glu Lys Val Ile Leu Ile Gln Ala Ser Asp Val Gly Asp Val His
     240                 245                 250

 gaa ggc ttc agg aca cta aaa gaa gaa gtt cag aga gag acc caa caa     1056
 Glu Gly Phe Arg Thr Leu Lys Glu Glu Val Gln Arg Glu Thr Gln Gln
 255                 260                 265                 270

 gtg gag aag ctg agc cga gta ggg caa agc tcc ctg ctc agc tcc ctc     1104
 Val Glu Lys Leu Ser Arg Val Gly Gln Ser Ser Leu Leu Ser Ser Leu
                 275                 280                 285

 agc aaa ctt cta ggg aag aaa aag gag cta caa gac ctt gag ctc gca     1152
 Ser Lys Leu Leu Gly Lys Lys Lys Glu Leu Gln Asp Leu Glu Leu Ala
             290                 295                 300

 ctt gaa ggg gct cta gac aag gga cat gaa gtg acc ctg gag gca ctc     1200
 Leu Glu Gly Ala Leu Asp Lys Gly His Glu Val Thr Leu Glu Ala Leu
         305                 310                 315

 cca aaa gat gtc ctg cta tca aag gag gcc gtg ggc gcc atc ctc tat     1248
 Pro Lys Asp Val Leu Leu Ser Lys Glu Ala Val Gly Ala Ile Leu Tyr
     320                 325                 330

 ttc gtt gga gcc cta aca gag cta agt gaa gcc caa cag aag ctg ctg     1296
 Phe Val Gly Ala Leu Thr Glu Leu Ser Glu Ala Gln Gln Lys Leu Leu
 335                 340                 345                 350

 gtg aaa tcc atg gag aaa aag atc cta ccc gtg cag cta aag ctg gtg     1344
 Val Lys Ser Met Glu Lys Lys Ile Leu Pro Val Gln Leu Lys Leu Val
                 355                 360                 365

 gag agc acg atg gaa cag aac ttc ctg ctg gat aaa gag ggt gtt ttc     1392
 Glu Ser Thr Met Glu Gln Asn Phe Leu Leu Asp Lys Glu Gly Val Phe
             370                 375                 380

 ccc ctg caa cct gag ctg ctc tcc tcc ctt ggg gac gag gag ctg acc     1440
 Pro Leu Gln Pro Glu Leu Leu Ser Ser Leu Gly Asp Glu Glu Leu Thr
         385                 390                 395

 ctc acg gag gct cta gtc ggg ctg agt ggc ctg gaa gtg cag aga tcg     1488
 Leu Thr Glu Ala Leu Val Gly Leu Ser Gly Leu Glu Val Gln Arg Ser
     400                 405                 410

 ggc ccc caa tat atg tgg gac cca gac acc ctc cct cgc ctc tgt gct     1536
 Gly Pro Gln Tyr Met Trp Asp Pro Asp Thr Leu Pro Arg Leu Cys Ala
 415                 420                 425                 430

 ctt tat gca ggc ctc tct ctc ctt cag cag ctt acc aag gcc tcc taa     1584
 Leu Tyr Ala Gly Leu Ser Leu Leu Gln Gln Leu Thr Lys Ala Ser 
                 435                 440                 445

 tttgcctttt acgtctgctt catgactccc taatgccttc ccaacctcgt ggtgctgtgt   1644

 ccttaccacc taagggcatt tcagagccat cagctgaaga catctgaaat ctcagctggt   1704

 cacccatgat aaccaacttc cacctgccca accatatatc accccctacc cctccagctc   1764

 cgcaacccac taagcccatc tgctgatgct taaattttct ttacttttct tttttttttt   1824

 ttgggggaga cagtacttat tgggtgaacc ctgaaaaagc tgcacgaggg ctgcgcctta   1884

 accggcaatt atccccgggg acacaagaaa catttgttgt gggaagggcc ccggaatatt   1944

 tggggaaggg tggagttcca caccggtcgc ctctgaggtg agctccatat tgtcgttcta   2004

 tatgcgaggg gcacagttgg acccgccaag gtgatcccac ccttgatagc atgacctagc   2064

 ctttggaaca aaaatataaa agggtccata accgccg                            2101




      <210> 271
      <211> 1116
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (3)..(1046)

      <400> 271
 tc   atg gcc ggc tcc tac cct gaa ggt gca cct gca atc ctc gcc gat      47
      Met Ala Gly Ser Tyr Pro Glu Gly Ala Pro Ala Ile Leu Ala Asp
        1               5                  10                  15

 aag agg cag cag ttc gga agc cgg ttc ctg agc gat ccg gcg cgg gtc       95
 Lys Arg Gln Gln Phe Gly Ser Arg Phe Leu Ser Asp Pro Ala Arg Val
                  20                  25                  30

 ttc cac cac aat gcc ttt gat tat gag atc aat gcc cac aaa tac tgg      143
 Phe His His Asn Ala Phe Asp Tyr Glu Ile Asn Ala His Lys Tyr Trp
              35                  40                  45

 aat gac ttc tac aaa atc cac gaa aat ggg ttt ttc aag gat aga cat      191
 Asn Asp Phe Tyr Lys Ile His Glu Asn Gly Phe Phe Lys Asp Arg His
          50                  55                  60

 tgg ctt ttt acc gaa ttc cct gag ctg gca cct agc caa aat caa aat      239
 Trp Leu Phe Thr Glu Phe Pro Glu Leu Ala Pro Ser Gln Asn Gln Asn
      65                  70                  75

 cat ttg aag gat tgg ttc ttg gag aac aag agt gaa gta tgt gaa tgt      287
 His Leu Lys Asp Trp Phe Leu Glu Asn Lys Ser Glu Val Cys Glu Cys
  80                  85                  90                  95

 aga aac aat gag gat gga cct ggt tta ata atg gaa gaa cag cac aag      335
 Arg Asn Asn Glu Asp Gly Pro Gly Leu Ile Met Glu Glu Gln His Lys
                 100                 105                 110

 tgt tct tcg aag agc ctt gaa cat aaa aca cag aca cct cct gtg gag      383
 Cys Ser Ser Lys Ser Leu Glu His Lys Thr Gln Thr Pro Pro Val Glu
             115                 120                 125

 gag aat gta act cag aaa att agt gac ctg gaa att tgt gct gat gag      431
 Glu Asn Val Thr Gln Lys Ile Ser Asp Leu Glu Ile Cys Ala Asp Glu
         130                 135                 140

 ttt cct gga tcc tca gcc acc tac cga ata ctg gag gtt ggc tgt ggt      479
 Phe Pro Gly Ser Ser Ala Thr Tyr Arg Ile Leu Glu Val Gly Cys Gly
     145                 150                 155

 gtg gga aac aca gtc ttt cca att tta caa acg aac aat gac cca gga      527
 Val Gly Asn Thr Val Phe Pro Ile Leu Gln Thr Asn Asn Asp Pro Gly
 160                 165                 170                 175

 ctc ttt gtt tat tgc tgt gat ttt tct tcc aca gct ata gaa ctg gtc      575
 Leu Phe Val Tyr Cys Cys Asp Phe Ser Ser Thr Ala Ile Glu Leu Val
                 180                 185                 190

 cag aca aat tca gaa tat gat cct tct cgg tgt ttt gcc ttt gtt cac      623
 Gln Thr Asn Ser Glu Tyr Asp Pro Ser Arg Cys Phe Ala Phe Val His
             195                 200                 205

 gac ctg tgt gat gaa gag aag agt tac cca gtg ccc aag ggc agt ctt      671
 Asp Leu Cys Asp Glu Glu Lys Ser Tyr Pro Val Pro Lys Gly Ser Leu
         210                 215                 220

 gat att atc att ctc ata ttt gtt ctt tca gca att gtt cca gac aag      719
 Asp Ile Ile Ile Leu Ile Phe Val Leu Ser Ala Ile Val Pro Asp Lys
     225                 230                 235

 atg cag aag gct atc aac agg ctg agc agg ctt ctg aaa cct ggg ggg      767
 Met Gln Lys Ala Ile Asn Arg Leu Ser Arg Leu Leu Lys Pro Gly Gly
 240                 245                 250                 255

 atg gta ctt ctg cga gat tac ggc cgc tat gac atg gct cag ctt cgg      815
 Met Val Leu Leu Arg Asp Tyr Gly Arg Tyr Asp Met Ala Gln Leu Arg
                 260                 265                 270

 ttt aaa aaa ggt cag tgt cta tct gga aat ttc tat gtg aga ggt gat      863
 Phe Lys Lys Gly Gln Cys Leu Ser Gly Asn Phe Tyr Val Arg Gly Asp
             275                 280                 285

 gga acc aga gtt tac ttc ttc aca caa gag gaa ctg gac acg ctt ttc      911
 Gly Thr Arg Val Tyr Phe Phe Thr Gln Glu Glu Leu Asp Thr Leu Phe
         290                 295                 300

 acc act gct gga ctg gaa aaa gtt cag aac ctg gtg gac cgc cga ctg      959
 Thr Thr Ala Gly Leu Glu Lys Val Gln Asn Leu Val Asp Arg Arg Leu
     305                 310                 315

 cag gtg aac cga ggg aag caa ctg aca atg tac cgg gtt tgg att cag     1007
 Gln Val Asn Arg Gly Lys Gln Leu Thr Met Tyr Arg Val Trp Ile Gln
 320                 325                 330                 335

 tgc aaa tac tgc aag ccc ctt ctg tcc agc acc agc taa gaggcacctg      1056
 Cys Lys Tyr Cys Lys Pro Leu Leu Ser Ser Thr Ser 
                 340                 345

 ctgccaacac gatgcaagcc cgttgtgttt ccgagctttt ttaaaaaaaa atttgtagca   1116




      <210> 272
      <211> 589
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (35)..(535)

      <400> 272
 cggcggtcct ggtgcggacc ctccggccgc agcc    atg tgg gac ccg cgg gca      52
                                          Met Trp Asp Pro Arg Ala
                                            1               5

 gct agg atg gac ctg aca gct tac gct gag ctg ctg aaa gaa tcc ggc      100
 Ala Arg Met Asp Leu Thr Ala Tyr Ala Glu Leu Leu Lys Glu Ser Gly
              10                  15                  20

 aac cag gtt ctt aag aat ggg aac ttc tct ttg gcc atc aga aag tac      148
 Asn Gln Val Leu Lys Asn Gly Asn Phe Ser Leu Ala Ile Arg Lys Tyr
          25                  30                  35

 gat gaa gcc atc cag att ctc ctg cag tta tac cag tgg ggg gtt ccc      196
 Asp Glu Ala Ile Gln Ile Leu Leu Gln Leu Tyr Gln Trp Gly Val Pro
      40                  45                  50

 ccg agg gac ttg gct gtg ctg ctg tgc aac aaa tca aat gca ttt ttc      244
 Pro Arg Asp Leu Ala Val Leu Leu Cys Asn Lys Ser Asn Ala Phe Phe
  55                  60                  65                  70

 agc ctt ggg aag tgg aat gag gca ttt gtt gct gcc aag gaa tgt ctc      292
 Ser Leu Gly Lys Trp Asn Glu Ala Phe Val Ala Ala Lys Glu Cys Leu
                  75                  80                  85

 caa tgg gat cca acc tac gtg aag gga tac tac cga gct ggt tat tcc      340
 Gln Trp Asp Pro Thr Tyr Val Lys Gly Tyr Tyr Arg Ala Gly Tyr Ser
              90                  95                 100

 ttg ctg agg ttg cac cag cct tac gaa gcc gct cgc atg ttt ttt gag      388
 Leu Leu Arg Leu His Gln Pro Tyr Glu Ala Ala Arg Met Phe Phe Glu
         105                 110                 115

 ggt ctg cga ctt gtg cag aga agc caa gac cag gca ccg gtt gct gat      436
 Gly Leu Arg Leu Val Gln Arg Ser Gln Asp Gln Ala Pro Val Ala Asp
     120                 125                 130

 ttc ctt gtt gga gtc ttc acc act gta ctt gct tgg cag aaa agc atg      484
 Phe Leu Val Gly Val Phe Thr Thr Val Leu Ala Trp Gln Lys Ser Met
 135                 140                 145                 150

 cat gag agg act gtg cat cgt tcc aag ctt gcc att tgg ctt acc agg      532
 His Glu Arg Thr Val His Arg Ser Lys Leu Ala Ile Trp Leu Thr Arg
                 155                 160                 165

 tag cctg tgatggtagt ggatgcagtc aagcctaaag ccttccgtac tcaatggtaa      589
 






      <210> 273
      <211> 7115
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (468)..(5813)

      <400> 273
 attcctcggg tcgacgattt cgtgcgagtg tagaccgtgc ggtccctgct cagcccctcc     60

 ggcctttccg agcgcgggag ccatcccgga cgggcgcggc tcctgggggg gctgaggtgc    120

 caagtttctg tgaaagccga cacgttgtgc ccctaatgga tcctatttac caaaaacagt    180

 tcagaaagaa aagagtccat tcttccagcc attcgttgct gacagccgct ggaaaggtct    240

 gggagtaaca ttgcacgagg gctctgtgta tgaatgacaa ggataccttc agccagctca    300

 ttctggatga atgaatgatt acactaagtg tcctccacat tcctctgtgg gctcacttca    360

 tggactcact ttgcgtgctt gttaaatgtg ctgtgttgct cccaagacca tgtaaagcct    420

 actgaccact aacctccctc acagcagaaa ctagacgtca ggttaaa  atg ggc aac     476
                                                      Met Gly Asn
                                                        1

 tcc gac agt cag tac acc ctt caa gga tct aaa aat cat agc aat act      524
 Ser Asp Ser Gln Tyr Thr Leu Gln Gly Ser Lys Asn His Ser Asn Thr
       5                  10                  15

 att act ggt gct aag caa att cct tgc tcc ctg aaa ata cgt ggc att      572
 Ile Thr Gly Ala Lys Gln Ile Pro Cys Ser Leu Lys Ile Arg Gly Ile
  20                  25                  30                  35

 cat gca aaa gag gaa aag tca ttg cat gga tgg ggt cac gga agc aac      620
 His Ala Lys Glu Glu Lys Ser Leu His Gly Trp Gly His Gly Ser Asn
                  40                  45                  50

 gga gca ggt tac aag tcc agg tcc ctg gcc cga agc tgc ctt tct cac      668
 Gly Ala Gly Tyr Lys Ser Arg Ser Leu Ala Arg Ser Cys Leu Ser His
              55                  60                  65

 ttt aag agt aac cag cct tac gca tcg aga ctc ggt ggc ccc aca tgc      716
 Phe Lys Ser Asn Gln Pro Tyr Ala Ser Arg Leu Gly Gly Pro Thr Cys
          70                  75                  80

 aag gtc tcc aga ggt gtt gcc tac tcc acg cac agg aca aat gcc cca      764
 Lys Val Ser Arg Gly Val Ala Tyr Ser Thr His Arg Thr Asn Ala Pro
      85                  90                  95

 ggg aag gat ttc cag ggc atc agt gct gct ttc tca act gag aat ggc      812
 Gly Lys Asp Phe Gln Gly Ile Ser Ala Ala Phe Ser Thr Glu Asn Gly
 100                 105                 110                 115

 ttc cac tct gtt ggc cac gag ctg gca gat aac cac atc acc tcc aga      860
 Phe His Ser Val Gly His Glu Leu Ala Asp Asn His Ile Thr Ser Arg
                 120                 125                 130

 gac tgc aac gga cac ctt ctc aac tgc tac ggg agg aat gag agc att      908
 Asp Cys Asn Gly His Leu Leu Asn Cys Tyr Gly Arg Asn Glu Ser Ile
             135                 140                 145

 gcc tcc acc cca ccg ggc gaa gac cgc aag agc ccc cga gtg ctc atc      956
 Ala Ser Thr Pro Pro Gly Glu Asp Arg Lys Ser Pro Arg Val Leu Ile
         150                 155                 160

 aaa acg ctg ggg aag ctg gat ggg tgt tta agg gtc gag ttc cac aat     1004
 Lys Thr Leu Gly Lys Leu Asp Gly Cys Leu Arg Val Glu Phe His Asn
     165                 170                 175

 ggt ggc aac ccc agc aaa gtg cct gca gag gac tgc agt gag ccg gtg     1052
 Gly Gly Asn Pro Ser Lys Val Pro Ala Glu Asp Cys Ser Glu Pro Val
 180                 185                 190                 195

 cag ctg ctg agg tac tca cct acc tta gca tcg gaa acc tcc cct gtg     1100
 Gln Leu Leu Arg Tyr Ser Pro Thr Leu Ala Ser Glu Thr Ser Pro Val
                 200                 205                 210

 cct gaa gcc agg agg ggg tcc agc gcc gat tcc ctg ccc agc cat cgc     1148
 Pro Glu Ala Arg Arg Gly Ser Ser Ala Asp Ser Leu Pro Ser His Arg
             215                 220                 225

 ccc tct ccc acg gac tct cgc ctg cgg tcc agc aaa ggc agc tcc ctg     1196
 Pro Ser Pro Thr Asp Ser Arg Leu Arg Ser Ser Lys Gly Ser Ser Leu
         230                 235                 240

 agt tct gag tca tcc tgg tac gac tcc cct tgg ggc aat gct gga gag     1244
 Ser Ser Glu Ser Ser Trp Tyr Asp Ser Pro Trp Gly Asn Ala Gly Glu
     245                 250                 255

 ctg agc gag gct gag ggc tcc ttc ctg gcc ccc ggc atg cct gac ccc     1292
 Leu Ser Glu Ala Glu Gly Ser Phe Leu Ala Pro Gly Met Pro Asp Pro
 260                 265                 270                 275

 agt ctc cat gcc agc ttc cca cct ggc gat gcc aaa aag cct ttc aac     1340
 Ser Leu His Ala Ser Phe Pro Pro Gly Asp Ala Lys Lys Pro Phe Asn
                 280                 285                 290

 caa agc tct tcc ctc tcc tcc ctc cgg gaa ctg tac aaa gat gcc aac     1388
 Gln Ser Ser Ser Leu Ser Ser Leu Arg Glu Leu Tyr Lys Asp Ala Asn
             295                 300                 305

 ctg ggg agc ctc tcc ccc tca ggt atc cgc ctt tct gat gaa tac atg     1436
 Leu Gly Ser Leu Ser Pro Ser Gly Ile Arg Leu Ser Asp Glu Tyr Met
         310                 315                 320

 ggc acg cat gcc agc ctg agc aac cgt gtc tct ttt gct tcc gac att     1484
 Gly Thr His Ala Ser Leu Ser Asn Arg Val Ser Phe Ala Ser Asp Ile
     325                 330                 335

 gat gtg ccc tcc aga gtg gca cac ggg gac ccc atc cag tac agt tcc     1532
 Asp Val Pro Ser Arg Val Ala His Gly Asp Pro Ile Gln Tyr Ser Ser
 340                 345                 350                 355

 ttc act ctc ccc tgt cgg aag ccc aaa gcc ttt gtt gag gat act gcg     1580
 Phe Thr Leu Pro Cys Arg Lys Pro Lys Ala Phe Val Glu Asp Thr Ala
                 360                 365                 370

 aag aag gac tcc ctc aaa gcc agg atg cga cgg atc agt gac tgg acg     1628
 Lys Lys Asp Ser Leu Lys Ala Arg Met Arg Arg Ile Ser Asp Trp Thr
             375                 380                 385

 gga agc ctc tca agg aag aaa agg aaa ctc cag gag ccg agg tcc aag     1676
 Gly Ser Leu Ser Arg Lys Lys Arg Lys Leu Gln Glu Pro Arg Ser Lys
         390                 395                 400

 gag ggc agt gac tac ttt gac agt cgc tct gat gga ctg aat aca gat     1724
 Glu Gly Ser Asp Tyr Phe Asp Ser Arg Ser Asp Gly Leu Asn Thr Asp
     405                 410                 415

 gtg cag gga tcc tcc cag gca tct gct ttt ctg tgg tca ggg ggc tct     1772
 Val Gln Gly Ser Ser Gln Ala Ser Ala Phe Leu Trp Ser Gly Gly Ser
 420                 425                 430                 435

 act cag atc ctg tct cag aga agt gaa tcc aca cat gcg att ggc agc     1820
 Thr Gln Ile Leu Ser Gln Arg Ser Glu Ser Thr His Ala Ile Gly Ser
                 440                 445                 450

 gat ccc ctc cgg cag aac att tat gag aat ttc atg cga gag ttg gaa     1868
 Asp Pro Leu Arg Gln Asn Ile Tyr Glu Asn Phe Met Arg Glu Leu Glu
             455                 460                 465

 atg agc agg acc aac act gag aac ata gaa aca tct aca gaa acc gcc     1916
 Met Ser Arg Thr Asn Thr Glu Asn Ile Glu Thr Ser Thr Glu Thr Ala
         470                 475                 480

 gag tcc agc agc gag tca ctc agc tct ctg gaa cag ctg gat ctg ctc     1964
 Glu Ser Ser Ser Glu Ser Leu Ser Ser Leu Glu Gln Leu Asp Leu Leu
     485                 490                 495

 ttt gag aag gaa cag ggg gtg gtc cgg aag gcc ggg tgg ctc ttc ttc     2012
 Phe Glu Lys Glu Gln Gly Val Val Arg Lys Ala Gly Trp Leu Phe Phe
 500                 505                 510                 515

 aag ccc ctg gtc act gtg cag aag gaa agg aag ctt gag ctg gtg gca     2060
 Lys Pro Leu Val Thr Val Gln Lys Glu Arg Lys Leu Glu Leu Val Ala
                 520                 525                 530

 cga agg aaa tgg aaa cag tac tgg gta acg ctg aaa gga gag agc aga     2108
 Arg Arg Lys Trp Lys Gln Tyr Trp Val Thr Leu Lys Gly Glu Ser Arg
             535                 540                 545

 aac atc tgc aaa tac tac gtg tgc aat gtc cag tgc cct ctc aat tac     2156
 Asn Ile Cys Lys Tyr Tyr Val Cys Asn Val Gln Cys Pro Leu Asn Tyr
         550                 555                 560

 ccc ttt cta gct ttt ctt tgc ccc tta tcg aac agt tgg agc cct gct     2204
 Pro Phe Leu Ala Phe Leu Cys Pro Leu Ser Asn Ser Trp Ser Pro Ala
     565                 570                 575

 tcc cca acc gtg gag ggc agg cat cat gcc ttc gtt acc aca agc ccc     2252
 Ser Pro Thr Val Glu Gly Arg His His Ala Phe Val Thr Thr Ser Pro
 580                 585                 590                 595

 tct ggc acc tct gga tgc acg ctg ctg ttt tat gag acc tat ggg aag     2300
 Ser Gly Thr Ser Gly Cys Thr Leu Leu Phe Tyr Glu Thr Tyr Gly Lys
                 600                 605                 610

 aat tcc atg gat cag agc agt gcc cct cgg tgt gct ctg ttt gca gaa     2348
 Asn Ser Met Asp Gln Ser Ser Ala Pro Arg Cys Ala Leu Phe Ala Glu
             615                 620                 625

 gac agc ata gtg cag tct gtt cca gag cat ccc aag aaa gaa aat gtg     2396
 Asp Ser Ile Val Gln Ser Val Pro Glu His Pro Lys Lys Glu Asn Val
         630                 635                 640

 ttc tgc ctc agc aac tcc ttt gga gat gtc tac ctt ttc cag gcc acc     2444
 Phe Cys Leu Ser Asn Ser Phe Gly Asp Val Tyr Leu Phe Gln Ala Thr
     645                 650                 655

 agc cag aca gat cta gaa aac tgg gtc act gct gta cac tct gct tgt     2492
 Ser Gln Thr Asp Leu Glu Asn Trp Val Thr Ala Val His Ser Ala Cys
 660                 665                 670                 675

 gca tcc ctt ttt gca aag aag cat ggg aaa gag gac acg ctg cgg ctg     2540
 Ala Ser Leu Phe Ala Lys Lys His Gly Lys Glu Asp Thr Leu Arg Leu
                 680                 685                 690

 ctg aag aac cag acc aaa aac ctg ctt cag aag ata gac atg gac agc     2588
 Leu Lys Asn Gln Thr Lys Asn Leu Leu Gln Lys Ile Asp Met Asp Ser
             695                 700                 705

 aag atg aag aag atg gca gag ctg cag ctg tcc gtg gtg agc gac cca     2636
 Lys Met Lys Lys Met Ala Glu Leu Gln Leu Ser Val Val Ser Asp Pro
         710                 715                 720

 aag aac agg aaa gcc ata gag aac cag atc cag caa tgg gag cag aat     2684
 Lys Asn Arg Lys Ala Ile Glu Asn Gln Ile Gln Gln Trp Glu Gln Asn
     725                 730                 735

 ctt gag aaa ttt cac atg gat ctg ttc agg atg cgc tgc tat ctg gcc     2732
 Leu Glu Lys Phe His Met Asp Leu Phe Arg Met Arg Cys Tyr Leu Ala
 740                 745                 750                 755

 agc cta caa ggt ggg gag tta ccg aac cca aag agt ctc ctt gca gcc     2780
 Ser Leu Gln Gly Gly Glu Leu Pro Asn Pro Lys Ser Leu Leu Ala Ala
                 760                 765                 770

 gcc agc cgc ccc tcc aag ctg gcc ctc ggc agg ctg ggc atc ttg tct     2828
 Ala Ser Arg Pro Ser Lys Leu Ala Leu Gly Arg Leu Gly Ile Leu Ser
             775                 780                 785

 gtt tcc tct ttc cat gct ctg gta tgt tct aga gat gac tct gct ctc     2876
 Val Ser Ser Phe His Ala Leu Val Cys Ser Arg Asp Asp Ser Ala Leu
         790                 795                 800

 cgg aaa agg aca ctg tca ctg acc cag cga ggg aga aac aag aag gga     2924
 Arg Lys Arg Thr Leu Ser Leu Thr Gln Arg Gly Arg Asn Lys Lys Gly
     805                 810                 815

 ata ttt tct tcg tta aaa ggg ctg gac aca ctg gcc aga aaa ggc aag     2972
 Ile Phe Ser Ser Leu Lys Gly Leu Asp Thr Leu Ala Arg Lys Gly Lys
 820                 825                 830                 835

 gag aag aga cct tct ata act cag ata ttt gat tca agt ggc agc cat     3020
 Glu Lys Arg Pro Ser Ile Thr Gln Ile Phe Asp Ser Ser Gly Ser His
                 840                 845                 850

 gga ttt tct gga act cag cta cct caa aac tcc agt aac tcc agt gag     3068
 Gly Phe Ser Gly Thr Gln Leu Pro Gln Asn Ser Ser Asn Ser Ser Glu
             855                 860                 865

 gtc gat gaa ctt ctg cat ata tat ggt tca aca gta gac ggt gtt ccc     3116
 Val Asp Glu Leu Leu His Ile Tyr Gly Ser Thr Val Asp Gly Val Pro
         870                 875                 880

 cga gac aat aca tgg gaa atc cag act tat gtc cac ttt cag gac aat     3164
 Arg Asp Asn Thr Trp Glu Ile Gln Thr Tyr Val His Phe Gln Asp Asn
     885                 890                 895

 cac gga gtt act gta ggg atc aag cca gag cac aga gta gaa gat att     3212
 His Gly Val Thr Val Gly Ile Lys Pro Glu His Arg Val Glu Asp Ile
 900                 905                 910                 915

 ttg act ttg gca tgc aag atg agg cag ttg gaa ccc agc cat tat ggc     3260
 Leu Thr Leu Ala Cys Lys Met Arg Gln Leu Glu Pro Ser His Tyr Gly
                 920                 925                 930

 cta cag ctt cga aaa tta gta gat gac aat gtt gag tat tgc atc cct     3308
 Leu Gln Leu Arg Lys Leu Val Asp Asp Asn Val Glu Tyr Cys Ile Pro
             935                 940                 945

 gca cca tat gaa tat atg caa caa cag gtt tat gat gaa ata gaa gtc     3356
 Ala Pro Tyr Glu Tyr Met Gln Gln Gln Val Tyr Asp Glu Ile Glu Val
         950                 955                 960

 ttt cca cta aat gtt tat gac gtg cag ctc acg aag act ggg agt gtg     3404
 Phe Pro Leu Asn Val Tyr Asp Val Gln Leu Thr Lys Thr Gly Ser Val
     965                 970                 975

 tgt gac ttt ggg ttt gca gtt aca gcg cag gtg gat gag cgt cag cat     3452
 Cys Asp Phe Gly Phe Ala Val Thr Ala Gln Val Asp Glu Arg Gln His
 980                 985                 990                 995

 ctc agc cgg ata ttt ata agc gac gtt ctt ccc gat ggc ctg gcg tat     3500
 Leu Ser Arg Ile Phe Ile Ser Asp Val Leu Pro Asp Gly Leu Ala Tyr
                1000                1005                1010

 ggg gaa ggg ctg aga aag ggc aat gag atc atg acc tta aat ggg gaa     3548
 Gly Glu Gly Leu Arg Lys Gly Asn Glu Ile Met Thr Leu Asn Gly Glu
            1015                1020                1025

 gct gtg tct gat ctt gac ctt aag cag atg gag gcc ctg ttt tct gag     3596
 Ala Val Ser Asp Leu Asp Leu Lys Gln Met Glu Ala Leu Phe Ser Glu
        1030                1035                1040

 aag agc gtc gga ctc act ctg att gcc cgg cct ccg gac aca aaa gca     3644
 Lys Ser Val Gly Leu Thr Leu Ile Ala Arg Pro Pro Asp Thr Lys Ala
    1045                1050                1055

 acc ctg tgt aca tcc tgg tca gac agt gac ctg ttc tcc agg gac cag     3692
 Thr Leu Cys Thr Ser Trp Ser Asp Ser Asp Leu Phe Ser Arg Asp Gln
1060                1065                1070                1075

 aag agt ctg ctg ccc cct cct aac cag tcc caa ctg ctg gag gaa ttc     3740
 Lys Ser Leu Leu Pro Pro Pro Asn Gln Ser Gln Leu Leu Glu Glu Phe
                1080                1085                1090

 ctg gat aac ttt aaa aag aat aca gcc aat gat ttc agc aac gtc cct     3788
 Leu Asp Asn Phe Lys Lys Asn Thr Ala Asn Asp Phe Ser Asn Val Pro
            1095                1100                1105

 gat atc aca aca ggt ctg aaa agg agt cag aca gat ggc act ctg gat     3836
 Asp Ile Thr Thr Gly Leu Lys Arg Ser Gln Thr Asp Gly Thr Leu Asp
        1110                1115                1120

 cag gtt tcc cac agg gag aaa atg gag cag aca ttc agg agt gct gag     3884
 Gln Val Ser His Arg Glu Lys Met Glu Gln Thr Phe Arg Ser Ala Glu
    1125                1130                1135

 cag atc act gca ctg tgc agg agt ttt aac gac agt cag gcc aac ggc     3932
 Gln Ile Thr Ala Leu Cys Arg Ser Phe Asn Asp Ser Gln Ala Asn Gly
1140                1145                1150                1155

 atg gaa gga ccg cgg gag aat cag gat cct cct ccg agg cct ctg gcc     3980
 Met Glu Gly Pro Arg Glu Asn Gln Asp Pro Pro Pro Arg Pro Leu Ala
                1160                1165                1170

 cgc cac ctg tct gat gca gac cgc ctc cgc aaa gtc atc cag gag ctt     4028
 Arg His Leu Ser Asp Ala Asp Arg Leu Arg Lys Val Ile Gln Glu Leu
            1175                1180                1185

 gtg gac aca gag aag tcc tac gtg aag gat ttg agc tgc ctc ttt gaa     4076
 Val Asp Thr Glu Lys Ser Tyr Val Lys Asp Leu Ser Cys Leu Phe Glu
        1190                1195                1200

 tta tac ttg gag cca ctt cag aat gag acc ttt ctt acc caa gat gag     4124
 Leu Tyr Leu Glu Pro Leu Gln Asn Glu Thr Phe Leu Thr Gln Asp Glu
    1205                1210                1215

 atg gag tca ctt ttt gga agt ttg cca gag atg ctt gag ttt cag aag     4172
 Met Glu Ser Leu Phe Gly Ser Leu Pro Glu Met Leu Glu Phe Gln Lys
1220                1225                1230                1235

 gtg ttt ctg gag acc ctg gag gat ggg att tca gca tca tct gac ttt     4220
 Val Phe Leu Glu Thr Leu Glu Asp Gly Ile Ser Ala Ser Ser Asp Phe
                1240                1245                1250

 aac acc cta gaa acc ccc tca cag ttt aga aaa tta ctg ttt tcc ctt     4268
 Asn Thr Leu Glu Thr Pro Ser Gln Phe Arg Lys Leu Leu Phe Ser Leu
            1255                1260                1265

 gga ggc tct ttc ctt tat tac gcg gac cac ttt aaa ctg tac agt gga     4316
 Gly Gly Ser Phe Leu Tyr Tyr Ala Asp His Phe Lys Leu Tyr Ser Gly
        1270                1275                1280

 ttc tgt gct aac cat atc aaa gta cag aag gtt ctg gag cga gct aaa     4364
 Phe Cys Ala Asn His Ile Lys Val Gln Lys Val Leu Glu Arg Ala Lys
    1285                1290                1295

 act gac aaa gcc ttc aag gct ttt ctg gac gcc cgg aac ccc acc aag     4412
 Thr Asp Lys Ala Phe Lys Ala Phe Leu Asp Ala Arg Asn Pro Thr Lys
1300                1305                1310                1315

 cag cat tcc tcc acg ctg gag tcc tac ctc atc aag ccg gtt cag aga     4460
 Gln His Ser Ser Thr Leu Glu Ser Tyr Leu Ile Lys Pro Val Gln Arg
                1320                1325                1330

 gtg ctc aag tac ccg ctg ctg ctc aag gag ctg gtg tcc ctg acg gac     4508
 Val Leu Lys Tyr Pro Leu Leu Leu Lys Glu Leu Val Ser Leu Thr Asp
            1335                1340                1345

 cag gag agc gag gag cac tac cac ctg acg gaa gca cta aag gca atg     4556
 Gln Glu Ser Glu Glu His Tyr His Leu Thr Glu Ala Leu Lys Ala Met
        1350                1355                1360

 gag aaa gta gcg agc cac atc aat gag atg cag aag atc tat gag gat     4604
 Glu Lys Val Ala Ser His Ile Asn Glu Met Gln Lys Ile Tyr Glu Asp
    1365                1370                1375

 tat ggg acc gtg ttt gac cag cta gta gct gag cag agc gga aca gag     4652
 Tyr Gly Thr Val Phe Asp Gln Leu Val Ala Glu Gln Ser Gly Thr Glu
1380                1385                1390                1395

 aag gag gta aca gaa ctt tcg atg gga gag ctt ctg atg cac tct acg     4700
 Lys Glu Val Thr Glu Leu Ser Met Gly Glu Leu Leu Met His Ser Thr
                1400                1405                1410

 gtt tcc tgg ttg aat cca ttt ctg tct cta gga aaa gct aga aag gac     4748
 Val Ser Trp Leu Asn Pro Phe Leu Ser Leu Gly Lys Ala Arg Lys Asp
            1415                1420                1425

 ctt gag ctc aca gta ttt gtt ttt aag aga gcc gtc ata ctg gtt tat     4796
 Leu Glu Leu Thr Val Phe Val Phe Lys Arg Ala Val Ile Leu Val Tyr
        1430                1435                1440

 aaa gaa aac tgc aaa ctg aaa aag aaa ttg ccc tcg aat tcc cgg cct     4844
 Lys Glu Asn Cys Lys Leu Lys Lys Lys Leu Pro Ser Asn Ser Arg Pro
    1445                1450                1455

 gca cac aac tct act gac ttg gac cca ttt aaa ttc cgc tgg ttg atc     4892
 Ala His Asn Ser Thr Asp Leu Asp Pro Phe Lys Phe Arg Trp Leu Ile
1460                1465                1470                1475

 ccc atc tcc gcg ctt caa gtc aga ctg ggg aat cca gca ggg aca gaa     4940
 Pro Ile Ser Ala Leu Gln Val Arg Leu Gly Asn Pro Ala Gly Thr Glu
                1480                1485                1490

 aat aat tcc ata tgg gaa ctg atc cat acg aag tca gaa ata gaa gga     4988
 Asn Asn Ser Ile Trp Glu Leu Ile His Thr Lys Ser Glu Ile Glu Gly
            1495                1500                1505

 cgg cca gaa acc atc ttt cag ttg tgt tgc agt gac agt gaa agc aaa     5036
 Arg Pro Glu Thr Ile Phe Gln Leu Cys Cys Ser Asp Ser Glu Ser Lys
        1510                1515                1520

 acc aac att gtt aag gtg att cgt tct att ctg agg gag aac ttc agg     5084
 Thr Asn Ile Val Lys Val Ile Arg Ser Ile Leu Arg Glu Asn Phe Arg
    1525                1530                1535

 cgt cac ata aag tgt gaa tta cca ctg gag aaa acg tgt aag gat cgc     5132
 Arg His Ile Lys Cys Glu Leu Pro Leu Glu Lys Thr Cys Lys Asp Arg
1540                1545                1550                1555

 ctg gta cct ctt aag aac cga gtt cct gtt tcg gcc aaa tta gct tca     5180
 Leu Val Pro Leu Lys Asn Arg Val Pro Val Ser Ala Lys Leu Ala Ser
                1560                1565                1570

 tcc agg tct tta aaa gtc ctg aag aat tcc tcc agc aac gag tgg acc     5228
 Ser Arg Ser Leu Lys Val Leu Lys Asn Ser Ser Ser Asn Glu Trp Thr
            1575                1580                1585

 ggt gag act ggc aag gga acc ttg ctg gac tct gac gag ggc agc ttg     5276
 Gly Glu Thr Gly Lys Gly Thr Leu Leu Asp Ser Asp Glu Gly Ser Leu
        1590                1595                1600

 agc agc ggc acc cag agc agc ggc tgc ccc acg gct gag ggc agg cag     5324
 Ser Ser Gly Thr Gln Ser Ser Gly Cys Pro Thr Ala Glu Gly Arg Gln
    1605                1610                1615

 gac tcc aag agc act tct ccc ggg aaa tac cca cac ccc ggc ttg gca     5372
 Asp Ser Lys Ser Thr Ser Pro Gly Lys Tyr Pro His Pro Gly Leu Ala
1620                1625                1630                1635

 gat ttt gct gac aat ctc atc aaa gag agt gac atc ctg agc gat gaa     5420
 Asp Phe Ala Asp Asn Leu Ile Lys Glu Ser Asp Ile Leu Ser Asp Glu
                1640                1645                1650

 gat gat gac cac cgt cag act gtg aag cag ggc agc cct act aaa gac     5468
 Asp Asp Asp His Arg Gln Thr Val Lys Gln Gly Ser Pro Thr Lys Asp
            1655                1660                1665

 atc gaa att cag ttc cag aga ctg agg att tcc gag gac cca gac gtt     5516
 Ile Glu Ile Gln Phe Gln Arg Leu Arg Ile Ser Glu Asp Pro Asp Val
        1670                1675                1680

 cac ccc gag gct gag cag cag cct ggc ccg gag tcg ggt gag ggt cag     5564
 His Pro Glu Ala Glu Gln Gln Pro Gly Pro Glu Ser Gly Glu Gly Gln
    1685                1690                1695

 aaa gga gga gag cag ccc aaa ctg gtc cgg ggg cac ttc tgc ccc att     5612
 Lys Gly Gly Glu Gln Pro Lys Leu Val Arg Gly His Phe Cys Pro Ile
1700                1705                1710                1715

 aaa cga aaa gcc aac agc acc aag agg gac aga gga act ttg ctc aag     5660
 Lys Arg Lys Ala Asn Ser Thr Lys Arg Asp Arg Gly Thr Leu Leu Lys
                1720                1725                1730

 gcg cag atc cgt cac cag tcc ctt gac agt cag tct gaa aat gcc acc     5708
 Ala Gln Ile Arg His Gln Ser Leu Asp Ser Gln Ser Glu Asn Ala Thr
            1735                1740                1745

 atc gac cta aat tct gtt cta gag cga gaa ttc agt gtc cag agt tta     5756
 Ile Asp Leu Asn Ser Val Leu Glu Arg Glu Phe Ser Val Gln Ser Leu
        1750                1755                1760

 aca tct gtt gtc agt gag gag tgt ttt tat gaa aca gag agc cac gga     5804
 Thr Ser Val Val Ser Glu Glu Cys Phe Tyr Glu Thr Glu Ser His Gly
    1765                1770                1775

 aaa tca tag tatgatt caatccagat atgggttaaa ttcctcattt tacttttaaa     5860
 Lys Ser 
1780

 ctggtggtaa agtggaaatt gcaaaaaaaa aaaaaaaaaa actgttcatt cctgggtttt   5920

 gtgcagtata cattttccca caaaatggtt gtaaagattt aagttatttt aatttattgt   5980

 ggatcagaaa cctagatgaa actggtcaga atctgtaaat tacttagttt atatccactt   6040

 tgagcaggta tcaaatgatt taggatcctt aaaattacat tctaataatt aagttatgtg   6100

 gaaaaagtaa ggctgggaag tcgtgattaa tagttttcaa aggccatttt ttaaaatcct   6160

 ctgggcattt tctttcagct gtttgttagt ttttgcttta tttaaagcat atttaagtta   6220

 ttttaatgtg gtttaggggc aaaatgtgca gatacttcat ttttgtaaga tagattgtaa   6280

 tagatgctgt ttatactaaa catgtcataa ctatctatac agtatatatt aaaagaaagc   6340

 ttgtactgta tcttatttga tgatatttat tttctctgcc aagctgtata gtaaaaggaa   6400

 aataagtcac atctggtcat tggcatttgt atcgtcattc tgtaaagaca aaagagtacc   6460

 tatataagaa gctccacgta gtgcaaatcg acatctggta ggctgctcgc ccccaggcag   6520

 cagctagagt ctgtaattct ctgcgtcatc ctcttctttt tcttcatttt tgctttttct   6580

 tcgcttgagt tcttctctga aattatatgc aaagagttgt gggtcttcat cacacatttt   6640

 tctgtataca tcacagaggc tcttaaagtg tgagatggag agctggtggg gccgaagagt   6700

 agggtctatg tctgccaact ctaacagcct gcccgtgctt tccaagcgct gcgcttcagg   6760

 gaataacatt ctgagccctc gatggcagta tttccttcgg aactgaaata cattctgaac   6820

 cactttttcc accagcttga atggctgctc tatcttgggc tgtatcaagg gagtgaagtg   6880

 caccacgccc acgtccacct tcgttgtaag caaacatatt atcattctgt ggcatgatat   6940

 gtggcatagt gtgatcaatc aactcatcct tgtaaaacag gaagatgggc tgtcaacagc   7000

 ctgttttcat aaacagacct ttccacgtac ttcggtttca tctctaggca tggaagatgg   7060

 tacattctgg attcgcaaat gacatggaga aatcagccgg ctgcacctgt tctct        7115




      <210> 274
      <211> 2629
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1467)..(2414)

      <400> 274
 tgtcttcctc caaccacatg ccccagcaac ctggggaccc tatggggaaa atgtcgctct     60

 atggggctca gcctgcattc accctggggc ctggacctgc aaccggacca gccctcaggg    120

 caacccaggc gtctccacgg gctgcctgtc tctcctggca ccctgctcct cccccttgga    180

 ggtcagcgcc atctctctgc taggctggcc ctggaaggcc actctgctgt ccccagagct    240

 ctcagccccc aggtctccac tggggagggt ggggcaggtg tcctggcagc ccccggaggg    300

 tgagatgaag agaggaggtc cttcaggaca ggggctcagg ccccagggct tgggacgacc    360

 agcactcctg gcagagagct ctaatttctg cttccgaaat gggtgtggac cggggttggg    420

 gtgggggggt ctctgggcaa gaagggtccc tcaagggctg gagctgcaaa tgtgccccct    480

 cccagggagt agagctgtag cctcatgtct tctaatgggg tgttatgagc tggggatgtt    540

 aaggtagggg tgaggggcag tgccatgcta gaggtgctca ctgcatcctt gggcctccat    600

 caaccatgag ggctgctctt tgttgggtga gacagactgg agaaggggga ggagggccag    660

 tcttcctcag gtcccaagct cgagccactc tccaatgtgc cccacatgtg atggagctcc    720

 cgggcggcac agaggatcag agggtgccct ctcaatgact ctggctctga gtcacctaat    780

 gataccgata cctactgctg tgggtaggta caccgcaggg aaatgaaagg cattggggtt    840

 ccaggcgtgg ggaacagggc agaggtttcc acctgaggcc ctcctgttaa ggtgacagca    900

 ttcccctaac tgtgcacccg ctgcctggta ctttatatag cactccaatc ctgtgtttta    960

 gccccatttg ggggaagaag aaatcgtggc tcagagtggt tgtaaaccac tcattcagct   1020

 tgtaagcgtc agggcctgat tccacagtgc tccttgagga gagggcaggg tgggagaaag   1080

 aaagggcagg gtgggagagg aagcgggacc ctaccctgac agcttaggga ctccgggact   1140

 gagcctgtgc ccaggtccac ttgcccgtct gggaccaccc agcctcccaa ggggggcgcc   1200

 aggagagccc tgggctcatc ttttctctct cctctgtact gtccgctctc ccccacagga   1260

 agaaaaccgt ctaccggagt ctgtgcctgg ccctggccct gctcgtggcc gtgacggtgt   1320

 tccaacgcag tctcacccct ggtcagtttc tgcaggagcc tccgccaccc accctggagc   1380

 cacagaaggc ccagaagcca aatggacagc tggtgaaccc caacaacttc tggaagaacc   1440

 cgaaagatgt ggctgcgccc acgccc atg gcc tct cag ggg ccc cag gcc tgg    1493
                              Met Ala Ser Gln Gly Pro Gln Ala Trp
                                1               5

 gac gtg acc acc act aac tgc tca gcc aat atc aac ttg acc cac cag     1541
 Asp Val Thr Thr Thr Asn Cys Ser Ala Asn Ile Asn Leu Thr His Gln
  10                  15                  20                  25

 ccc tgg ttc cag gtc ctg gag ccg cag ttc cgg cag ttt ctc ttc tac     1589
 Pro Trp Phe Gln Val Leu Glu Pro Gln Phe Arg Gln Phe Leu Phe Tyr
                  30                  35                  40

 cgc cac tgc cgc tac ttc ccc atg ctg ctg aac cac ccg gag aag tgc     1637
 Arg His Cys Arg Tyr Phe Pro Met Leu Leu Asn His Pro Glu Lys Cys
              45                  50                  55

 agg ggc gat gtc tac ctg ctg gtg gtt gtc aag tcg gtc atc acg cag     1685
 Arg Gly Asp Val Tyr Leu Leu Val Val Val Lys Ser Val Ile Thr Gln
          60                  65                  70

 cac gac cgc cgc gag gcc atc cgc cag acc tgg ggc cgc gag cgg cag     1733
 His Asp Arg Arg Glu Ala Ile Arg Gln Thr Trp Gly Arg Glu Arg Gln
      75                  80                  85

 tcc gcg ggt ggg ggc cga ggc gcc gtg cgc acc ctc ttc ctg ctg ggc     1781
 Ser Ala Gly Gly Gly Arg Gly Ala Val Arg Thr Leu Phe Leu Leu Gly
  90                  95                 100                 105

 acg gcc tcc aag cag gag gag cgc acg cac tac cag cag ctg ctg gcc     1829
 Thr Ala Ser Lys Gln Glu Glu Arg Thr His Tyr Gln Gln Leu Leu Ala
                 110                 115                 120

 tac gaa gac cgc ctc tac ggc gac atc ctg cag tgg ggc ttt ctc gac     1877
 Tyr Glu Asp Arg Leu Tyr Gly Asp Ile Leu Gln Trp Gly Phe Leu Asp
             125                 130                 135

 acc ttc ttc aac ctg acc ctc aag gag atc cac ttc ctc aag tgg ctg     1925
 Thr Phe Phe Asn Leu Thr Leu Lys Glu Ile His Phe Leu Lys Trp Leu
         140                 145                 150

 gac atc tac tgc ccc cac gtc ccc ttc att ttc aaa ggc gac gat gac     1973
 Asp Ile Tyr Cys Pro His Val Pro Phe Ile Phe Lys Gly Asp Asp Asp
     155                 160                 165

 gtc ttc gtc aac ccc acc aac ctg ttc gtg ggc gat gtc ctg cag cac     2021
 Val Phe Val Asn Pro Thr Asn Leu Phe Val Gly Asp Val Leu Gln His
 170                 175                 180                 185

 gct cgg ccc att cgc agg aaa gac aac aaa tac tac atc ccg ggg gcc     2069
 Ala Arg Pro Ile Arg Arg Lys Asp Asn Lys Tyr Tyr Ile Pro Gly Ala
                 190                 195                 200

 ctg tac ggc aag gcc agc tat ccg ccg tat gca ggc ggc ggt ggc ttc     2117
 Leu Tyr Gly Lys Ala Ser Tyr Pro Pro Tyr Ala Gly Gly Gly Gly Phe
             205                 210                 215

 ctc atg gcc ggc agc ctg gcc cgg cgc ctg cac cat gcc tgc gac acc     2165
 Leu Met Ala Gly Ser Leu Ala Arg Arg Leu His His Ala Cys Asp Thr
         220                 225                 230

 ctg gag ctc tac ccg atc gac gac gtc ttt ctg ggc atg tgc ctg gag     2213
 Leu Glu Leu Tyr Pro Ile Asp Asp Val Phe Leu Gly Met Cys Leu Glu
     235                 240                 245

 gtg ctg ggc gtg cag ccc acg gcc cac gag ggc ttc aag act ttc ggc     2261
 Val Leu Gly Val Gln Pro Thr Ala His Glu Gly Phe Lys Thr Phe Gly
 250                 255                 260                 265

 atc tcc cgg aac cgc aac agc cgc atg aac aag gag ccg tgc ttt ttc     2309
 Ile Ser Arg Asn Arg Asn Ser Arg Met Asn Lys Glu Pro Cys Phe Phe
                 270                 275                 280

 cgc gcc atg ctc gtg gtg cac aag ctg ctg ccc cct gag ctg ctc gcc     2357
 Arg Ala Met Leu Val Val His Lys Leu Leu Pro Pro Glu Leu Leu Ala
             285                 290                 295

 atg tgg ggg ctg gtg cac agc aat ctc acc tgc tcc cgc aag ctc cag     2405
 Met Trp Gly Leu Val His Ser Asn Leu Thr Cys Ser Arg Lys Leu Gln
         300                 305                 310

 gtg ctc tga ccccagc cgggctacta ggacaggcca gggcacttgc tcctgagccc     2461
 Val Leu 
     315

 ccatggtatt ggggctggag ccacagtgcc caggcctagc ctttggtccc caaggggagg   2521

 tggagggttg aggcctacgt gccactgggt gtggtggggt gcaggtagcc agaaagggac   2581

 ctccctgtgt ggataattct aggaaactga ggcccaggaa cggttgga                2629




      <210> 275
      <211> 1188
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (85)..(1188)

      <400> 275
 atggatgagg cagctgtgac tccagcagcc atcttgggcc atgaggtgat ggagaggatg     60

 gaaaccccaa gggctgtggg gcat   atg ggg cga ggg ggc gaa gga gga tgt     111
                              Met Gly Arg Gly Gly Glu Gly Gly Cys
                                1               5

 cag aga gat gga gga cca ggt ccc cag tgc ccc cac ccc ttc tgc tcc      159
 Gln Arg Asp Gly Gly Pro Gly Pro Gln Cys Pro His Pro Phe Cys Ser
  10                  15                  20                  25

 cct gcc cac ccc ggg cca ccc agt ggc cca atc cac ccc acg ctc agc      207
 Pro Ala His Pro Gly Pro Pro Ser Gly Pro Ile His Pro Thr Leu Ser
                  30                  35                  40

 ctg tgc cag gtt cag gtt cag gaa ggg aca tgg act cag acc tct ggg      255
 Leu Cys Gln Val Gln Val Gln Glu Gly Thr Trp Thr Gln Thr Ser Gly
              45                  50                  55

 gat gct cag tca gat gga gga tac atg gac cct gac tct ggg agc tcc      303
 Asp Ala Gln Ser Asp Gly Gly Tyr Met Asp Pro Asp Ser Gly Ser Ser
          60                  65                  70

 cag tct gat gga gga gac ata gac cct gac tct ggg atc tcc cag tct      351
 Gln Ser Asp Gly Gly Asp Ile Asp Pro Asp Ser Gly Ile Ser Gln Ser
      75                  80                  85

 gat gga gga gac atg gtc cct gac tct ggg agc tcc cag tct gat gga      399
 Asp Gly Gly Asp Met Val Pro Asp Ser Gly Ser Ser Gln Ser Asp Gly
  90                  95                 100                 105

 gga gac atg ctc cct gac tct ggg agc tcc cag tct gat gga gga gac      447
 Gly Asp Met Leu Pro Asp Ser Gly Ser Ser Gln Ser Asp Gly Gly Asp
                 110                 115                 120

 atg gtc cct gac tct ggg agc tcc cag tct gat gga gga gac atg gtc      495
 Met Val Pro Asp Ser Gly Ser Ser Gln Ser Asp Gly Gly Asp Met Val
             125                 130                 135

 cct gac tct ggg agc tcc cag tct gat gga gga gac atg gtc cct gac      543
 Pro Asp Ser Gly Ser Ser Gln Ser Asp Gly Gly Asp Met Val Pro Asp
         140                 145                 150

 tct ggg agc tcc cag tct gat gga gga gac ata gac cct gac tct ggg      591
 Ser Gly Ser Ser Gln Ser Asp Gly Gly Asp Ile Asp Pro Asp Ser Gly
     155                 160                 165

 agc tcc cag tct gat gga gga gac atg gac cat gcc tct ggg agc tcc      639
 Ser Ser Gln Ser Asp Gly Gly Asp Met Asp His Ala Ser Gly Ser Ser
 170                 175                 180                 185

 cgg tct gat gga gga gac ata gac cct gac tct ggg agc tcc cgg tct      687
 Arg Ser Asp Gly Gly Asp Ile Asp Pro Asp Ser Gly Ser Ser Arg Ser
                 190                 195                 200

 gat gga gga gac atg gtc cct gac tct ggg agc tcc cag tct gat gaa      735
 Asp Gly Gly Asp Met Val Pro Asp Ser Gly Ser Ser Gln Ser Asp Glu
             205                 210                 215

 gga gac atg gtc cct gac tct ggg agc tcc cag tct gat gaa gga gac      783
 Gly Asp Met Val Pro Asp Ser Gly Ser Ser Gln Ser Asp Glu Gly Asp
         220                 225                 230

 atg gtc cct gac tct ggg agc tcc cgg tct gat gga gga gac ata gac      831
 Met Val Pro Asp Ser Gly Ser Ser Arg Ser Asp Gly Gly Asp Ile Asp
     235                 240                 245

 cct gac tct ggg agc tcc cag tct gat gga gga gac atg gtc cct gac      879
 Pro Asp Ser Gly Ser Ser Gln Ser Asp Gly Gly Asp Met Val Pro Asp
 250                 255                 260                 265

 tct ggg agc tcc cag tct gat gga gga aac atg gtc cct gac tct ggg      927
 Ser Gly Ser Ser Gln Ser Asp Gly Gly Asn Met Val Pro Asp Ser Gly
                 270                 275                 280

 agc tcc cag tct gat gga gga gac atg gac cct cac tcc tgg agt tcc      975
 Ser Ser Gln Ser Asp Gly Gly Asp Met Asp Pro His Ser Trp Ser Ser
             285                 290                 295

 cag tct gac gag gga gac ata gtc cct gac tcc ggg agc tcc cag tct     1023
 Gln Ser Asp Glu Gly Asp Ile Val Pro Asp Ser Gly Ser Ser Gln Ser
         300                 305                 310

 gat gga gga gac atg gac cat gcc tct ggg agc tcc cag tct gat gaa     1071
 Asp Gly Gly Asp Met Asp His Ala Ser Gly Ser Ser Gln Ser Asp Glu
     315                 320                 325

 gga gac gtg gtc tct gcc tct ggg agc tcc cag tct gac gga gga aac     1119
 Gly Asp Val Val Ser Ala Ser Gly Ser Ser Gln Ser Asp Gly Gly Asn
 330                 335                 340                 345

 atg gtc tat aac tct ggg agc tct cag tct gat gga gga gac ctg gat     1167
 Met Val Tyr Asn Ser Gly Ser Ser Gln Ser Asp Gly Gly Asp Leu Asp
                 350                 355                 360

 ctt gac tct ggg agc tcc tag                                         1188
 Leu Asp Ser Gly Ser Ser 
             365





      <210> 276
      <211> 1150
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (21)..(371)

      <400> 276
 tgcctgcagc ctccggagcc    atg gga aca ggg ctg cga agt cag tcc ttg      50
                          Met Gly Thr Gly Leu Arg Ser Gln Ser Leu
                            1               5                  10

 cga gag ccc cga ccc tcc tat gga aag ctg cag gag ccc tgg ggg agg       98
 Arg Glu Pro Arg Pro Ser Tyr Gly Lys Leu Gln Glu Pro Trp Gly Arg
                  15                  20                  25

 ccc cag gag ggc caa ctc cgc agg gcg cta agc ctc aga cag ggg caa      146
 Pro Gln Glu Gly Gln Leu Arg Arg Ala Leu Ser Leu Arg Gln Gly Gln
              30                  35                  40

 gag aag tcc agg tcc cag ggc ctc gag aga ggc aca gaa ggg cca gat      194
 Glu Lys Ser Arg Ser Gln Gly Leu Glu Arg Gly Thr Glu Gly Pro Asp
          45                  50                  55

 gcc act gcc cag gag cgg gtg ccg ggg agc ctg ggg gac aca gag cag      242
 Ala Thr Ala Gln Glu Arg Val Pro Gly Ser Leu Gly Asp Thr Glu Gln
      60                  65                  70

 ctg atc caa gcc cag cga aga ggc agc cgg tgg tgg ctg agg cgg tac      290
 Leu Ile Gln Ala Gln Arg Arg Gly Ser Arg Trp Trp Leu Arg Arg Tyr
  75                  80                  85                  90

 caa cag cag gta aga aga agg tgg gag agc ttt gtc gcc atc ttc ccc      338
 Gln Gln Gln Val Arg Arg Arg Trp Glu Ser Phe Val Ala Ile Phe Pro
                  95                 100                 105

 agc gtg act ctg agt cag ccg gcc tcc ccg tag cccacact gggcaccatc      389
 Ser Val Thr Leu Ser Gln Pro Ala Ser Pro 
             110                 115

 agctaaagat gctggaagcc atcgtggccc ccttgctgtg cctggaccag cccaccgtgt    449

 ctgctgacct acctcttcac agctctctgg actttggctg ggtggcccta ggaggcttct    509

 gccaccagct cactggagtc gccacgtggc tgccactctt agctctggcc cttccactcc    569

 agcactagct ctctttgaag atcccagcag ggtcaaaaag aagggggctc agctgtctgc    629

 cctctgggct tgggtagggg ccttggacta tgattctatg aaggtttaga agaagcctgc    689

 ccggaatggg ggctgtggac gctcctgccc cacacgacca gctgtcaact tccaggacgg    749

 agcttgatga agccagaccc atggccgaga ggctcacgga cgttgcctgg tcactgggcc    809

 atgacccaac tgcccttctt gtcagttgct gatggtgggc cagggcgcag gtctccctcc    869

 cagatggtga gccctctggg gcaaggacca cagctgggtg gccctcctgg ctgagcactc    929

 tgtgctgaaa acctttgaac ctcacggtgt cctgatgaag gaagcagagg aagtcttcct    989

 ccctgtgtga cagaggggga aactgaggcc cagagtgggg aagggatttc ttggttttga   1049

 catctccgac cccaccccac cccatccagt gtccagcact ggagtcgaac acagtaataa   1109

 agatgctgag aaaaagtcaa aaaaaaaaaa aaaaaaagac g                       1150




      <210> 277
      <211> 1688
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (557)..(1339)

      <400> 277
 atccatgcta aggtaaacaa actgcaactt atatctgcaa tttattttgg tatagacaag     60

 aggtatgcca gtagcacact ggtggcttca gaagaaattc tcaacaccta gctcgccaga    120

 gagtctatgt atgggattga acaatctgta aactaaagga tcctaatcat gaaaataagt    180

 atgataaatt ataagtcact attggcactg ttgtttatat tagcctcctg gatcattttt    240

 acagttttcc agaactccac aaaggtttgg tctgctctaa acttatccat ctccctccat    300

 tactggaaca actccacaaa gtccttattc cctaaaacac cactgatatc attaaagcca    360

 ctaacagaga ctgaactcag aataaaggaa atcatagaga aactagatca gcagatccca    420

 cccagacctt tcacccacgt gaacaccacc accagcgcca cacatagcac agccaccatc    480

 ctcaaccctc gagatacgta ctgcagggga gaccagctgc acatcctact ggaggtcaaa    540

 tgtgggtgta gagatt    atg gaa aaa ttc aat aca att agt gcc tcc aaa     589
                      Met Glu Lys Phe Asn Thr Ile Ser Ala Ser Lys
                        1               5                  10

 tgc aac aaa gaa aca gtt gca atg aaa gag aaa tgc aag ttt gga atg      637
 Cys Asn Lys Glu Thr Val Ala Met Lys Glu Lys Cys Lys Phe Gly Met
              15                  20                  25

 aca tcc aca atc ccc agt ggg cat gtc tgg aga aac aca tgg aat cct      685
 Thr Ser Thr Ile Pro Ser Gly His Val Trp Arg Asn Thr Trp Asn Pro
          30                  35                  40

 gtc tcc tgt agt ttg gct aca gtc aaa atg aag gaa tgc ctg aga gga      733
 Val Ser Cys Ser Leu Ala Thr Val Lys Met Lys Glu Cys Leu Arg Gly
      45                  50                  55

 aaa ctc ata tac cta atg gga gat tcc acg atc cgc cag tgg atg gaa      781
 Lys Leu Ile Tyr Leu Met Gly Asp Ser Thr Ile Arg Gln Trp Met Glu
  60                  65                  70                  75

 tac ttc aaa gcc agt atc aac aca ctg aag tca gtg gat ctg cat gaa      829
 Tyr Phe Lys Ala Ser Ile Asn Thr Leu Lys Ser Val Asp Leu His Glu
                  80                  85                  90

 tct gga aaa ttg caa cac cag ctt gct gtg gat ttg gat agg aac atc      877
 Ser Gly Lys Leu Gln His Gln Leu Ala Val Asp Leu Asp Arg Asn Ile
              95                 100                 105

 aac atc cag tgg caa aaa cat tgt tat ccc ttg ata gga tca atg acc      925
 Asn Ile Gln Trp Gln Lys His Cys Tyr Pro Leu Ile Gly Ser Met Thr
         110                 115                 120

 tat tca gtc aaa gag atg gag tac ctc acc cgg gcc att gac aga act      973
 Tyr Ser Val Lys Glu Met Glu Tyr Leu Thr Arg Ala Ile Asp Arg Thr
     125                 130                 135

 gga gga gaa aaa aat act gtc att gtt att tcc ctg ggc cag cat ttc     1021
 Gly Gly Glu Lys Asn Thr Val Ile Val Ile Ser Leu Gly Gln His Phe
 140                 145                 150                 155

 aga ccc ttt ccc att gat gtt ttt atc cga agg gtc ctc aat gtc cac     1069
 Arg Pro Phe Pro Ile Asp Val Phe Ile Arg Arg Val Leu Asn Val His
                 160                 165                 170

 aaa gcc att cag cat ctt ctt ctg aga agc cca gac act atg gtt atc     1117
 Lys Ala Ile Gln His Leu Leu Leu Arg Ser Pro Asp Thr Met Val Ile
             175                 180                 185

 atc aaa aca gaa aac atc agg gag atg tac aat gat gca gaa aga ttt     1165
 Ile Lys Thr Glu Asn Ile Arg Glu Met Tyr Asn Asp Ala Glu Arg Phe
         190                 195                 200

 agt gac ttt cat ggt tac att caa tat ctc atc ata aag gac att ttc     1213
 Ser Asp Phe His Gly Tyr Ile Gln Tyr Leu Ile Ile Lys Asp Ile Phe
     205                 210                 215

 cag gat ctc agt gtg agt atc att gat gcc tgg gat ata aca att gca     1261
 Gln Asp Leu Ser Val Ser Ile Ile Asp Ala Trp Asp Ile Thr Ile Ala
 220                 225                 230                 235

 tat ggc aca aat aat gta cac cca cct caa cat gta gtc gga aat cag     1309
 Tyr Gly Thr Asn Asn Val His Pro Pro Gln His Val Val Gly Asn Gln
                 240                 245                 250

 att aat ata tta tta aac tat att tgt taa a taacaaaaaa gtctgaaatt     1360
 Ile Asn Ile Leu Leu Asn Tyr Ile Cys 
             255                 260

 cattcactta agtaaaaaaa tttattgact gtctactagc aggccagatg ctgtgtttgg   1420

 ctctgaattc ccaactagca agagcagaga atctacatta tggctgatcc ataagccacc   1480

 aattcagcta aatgagatgt ttctaatctg ggcttccact taaaaataaa actaaaaata   1540

 ctcatgaaaa gagcctaccc ttcttgatca gagccatacc cctcttcacc aatgggaagt   1600

 caagacacct atgggtaaaa gttctctctg atgcatgaaa actcagagtg ataaagtaat   1660

 tttaaaataa aaatttggag aaagcaaa                                      1688




      <210> 278
      <211> 902
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (22)..(321)

      <220>
      <221> misc_feature
      <222> (1)...(902)
      <223> n = a,t,c or g

      <400> 278
 tcttccggtg cgtgccggac c  atg ggg ctg ggg cag cgt atg ttt ttg gct      51
                          Met Gly Leu Gly Gln Arg Met Phe Leu Ala
                            1               5                  10

 cac aca tcc gta gag agt ttt acc gcc ccg gcc tcc ttt gaa aag aat       99
 His Thr Ser Val Glu Ser Phe Thr Ala Pro Ala Ser Phe Glu Lys Asn
                  15                  20                  25

 cgg tgc cca aga atg ggc ggt cgg gat atc cat acc atg aag gcg cgc      147
 Arg Cys Pro Arg Met Gly Gly Arg Asp Ile His Thr Met Lys Ala Arg
              30                  35                  40

 gtc ccg cag cat cat aag ctt gag aag atc cta gaa gtc gga atc cgg      195
 Val Pro Gln His His Lys Leu Glu Lys Ile Leu Glu Val Gly Ile Arg
          45                  50                  55

 aag aag atc gaa cat gac gcg gtg atg aaa gcc agc agc agc ctg ccc      243
 Lys Lys Ile Glu His Asp Ala Val Met Lys Ala Ser Ser Ser Leu Pro
      60                  65                  70

 aag aag ctg gca ctg ttg aag gcc cca gcc aag aag aaa ggg gca gat      291
 Lys Lys Leu Ala Leu Leu Lys Ala Pro Ala Lys Lys Lys Gly Ala Asp
  75                  80                  85                  90

 gcc gcc acc tcc tcc aag aca cct ttc tga g gacgctggcc ccagtgcagg      342
 Ala Ala Thr Ser Ser Lys Thr Pro Phe 
                  95

 ccaacattcc accccctacc tccatatggg accttgcaag gcatcccaca ggctgcactg    402

 gcaggaagag gaccctgtcc cccagcactg ggcttcacct agaacttcag tgggggccaa    462

 gggtgctgag aacccagcaa tgaccaggaa gatacagtca ctaacttcat ctgtccccgt    522

 gccccttccc aggtcctgcc tccacaggtt taacccagaa caataaacct ggctttgtca    582

 gcaaaaaaaa aaaaaaactt gggggggggc cgggacccca tttcgcctta tggggggtcg    642

 aataacaatt catggcccgt cgtttaacaa cggcgggact gggaaaaanc atagtacgta    702

 cggatgtaat tctgtgtatc ttactgtgac tccgaaaact gtagtattgg tgtcatggga    762

 atgtacgtta tttccaaagt catttcatta aagatgaaaa ctttaaaaaa aaaaaagggg    822

 gggcccggaa cccaattagc ccttagtgag tggtattaca attccctggc cgtgggttaa    882

 aacgttggga ttggggaaaa                                                902




      <210> 279
      <211> 960
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(960)

      <400> 279
  atg cag ctc ttt gtc cgc gcc cag gag cta cac acc ttc gag gtg acc      48
  Met Gln Leu Phe Val Arg Ala Gln Glu Leu His Thr Phe Glu Val Thr
    1               5                  10                  15

 ggc cag gaa acg gtc gcc cag atc aag gct cat gta gcc tca ctg gag       96
 Gly Gln Glu Thr Val Ala Gln Ile Lys Ala His Val Ala Ser Leu Glu
              20                  25                  30

 ggc att gcc ccg gaa gat caa gtc gtg ctc ctg gca ggc gcg ccc ctg      144
 Gly Ile Ala Pro Glu Asp Gln Val Val Leu Leu Ala Gly Ala Pro Leu
          35                  40                  45

 gag gat gag gcc act ctg ggc cag tgc ggt gtg gag gcc ctg act acc      192
 Glu Asp Glu Ala Thr Leu Gly Gln Cys Gly Val Glu Ala Leu Thr Thr
      50                  55                  60

 ctg gaa gta gca ggc cgc atg ctt gga ggt aaa gtc cat ggt tcc ctg      240
 Leu Glu Val Ala Gly Arg Met Leu Gly Gly Lys Val His Gly Ser Leu
  65                  70                  75                  80

 gcc cgt gct ggg aca ggt cgg gct aag cgg cgg atg cag tac aac cgg      288
 Ala Arg Ala Gly Thr Gly Arg Ala Lys Arg Arg Met Gln Tyr Asn Arg
                  85                  90                  95

 cgc ttt gtc aac gtt gtg ccc acc ttt ggc aag aag aag ggc acc acg      336
 Arg Phe Val Asn Val Val Pro Thr Phe Gly Lys Lys Lys Gly Thr Thr
             100                 105                 110

 ttc acc aag atc ttc gtg ggc ggc ctg ccg tac cac act acc gac gcc      384
 Phe Thr Lys Ile Phe Val Gly Gly Leu Pro Tyr His Thr Thr Asp Ala
         115                 120                 125

 tcg ctc agg aag tac ttc gag ggc ttc ggc gac atc gag gag gcc gtg      432
 Ser Leu Arg Lys Tyr Phe Glu Gly Phe Gly Asp Ile Glu Glu Ala Val
     130                 135                 140

 gtc atc acc gac cgc cag acg ggc aag tcc cgc ggc tac ggc ttc gtg      480
 Val Ile Thr Asp Arg Gln Thr Gly Lys Ser Arg Gly Tyr Gly Phe Val
 145                 150                 155                 160

 acc atg gcc gac cgg gcg gca gct gag agg gct tgc aaa gac ccg aac      528
 Thr Met Ala Asp Arg Ala Ala Ala Glu Arg Ala Cys Lys Asp Pro Asn
                 165                 170                 175

 ccc atc atc gac ggc cgc aag gcc aac gtg aac ctg gca tat ctg ggc      576
 Pro Ile Ile Asp Gly Arg Lys Ala Asn Val Asn Leu Ala Tyr Leu Gly
             180                 185                 190

 gcc aag ccg cgg agc ctc cag acg ggc ttt gcc att ggg gtg cag cag      624
 Ala Lys Pro Arg Ser Leu Gln Thr Gly Phe Ala Ile Gly Val Gln Gln
         195                 200                 205

 ctg cac ccc acc ttg atc cag cgg act tac ggg ctg acc ccg cac tac      672
 Leu His Pro Thr Leu Ile Gln Arg Thr Tyr Gly Leu Thr Pro His Tyr
     210                 215                 220

 atc tac cca cca gcc atc gtg cag ccc agc gtg gtg atc cca gcc gcc      720
 Ile Tyr Pro Pro Ala Ile Val Gln Pro Ser Val Val Ile Pro Ala Ala
 225                 230                 235                 240

 cct gtc ccg tcg ctg tcc tcg ccc tac att gag tac acg ccg gcc agc      768
 Pro Val Pro Ser Leu Ser Ser Pro Tyr Ile Glu Tyr Thr Pro Ala Ser
                 245                 250                 255

 ccg gcc tac gcc cag tac cca ccg gcc acc tat gac cag tac cca tac      816
 Pro Ala Tyr Ala Gln Tyr Pro Pro Ala Thr Tyr Asp Gln Tyr Pro Tyr
             260                 265                 270

 gcc gcc tcg cct gcc acg gct gcc agc ttc gtg ggc tac agc tac cct      864
 Ala Ala Ser Pro Ala Thr Ala Ala Ser Phe Val Gly Tyr Ser Tyr Pro
         275                 280                 285

 gcc gcc gtg ccc cag gcc ctc tca gcc gca gca ccc gcg ggc acc act      912
 Ala Ala Val Pro Gln Ala Leu Ser Ala Ala Ala Pro Ala Gly Thr Thr
     290                 295                 300

 ttc gtg cag tac cag gcg ccg cag ctg cag cct gac agg atg cag tga      960
 Phe Val Gln Tyr Gln Ala Pro Gln Leu Gln Pro Asp Arg Met Gln 
 305                 310                 315





      <210> 280
      <211> 804
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(804)

      <400> 280
  atg ctt gga ggt aaa gtc cat ggt tcc ctg gcc cgt gct gga aaa gtg      48
  Met Leu Gly Gly Lys Val His Gly Ser Leu Ala Arg Ala Gly Lys Val
    1               5                  10                  15

 aga ggt cag act cct aag gtg gcc aaa cag gag aag aag aag aag aag       96
 Arg Gly Gln Thr Pro Lys Val Ala Lys Gln Glu Lys Lys Lys Lys Lys
              20                  25                  30

 aca ggt cgg gct aag cgg cgg atg cag tac aac cgg cgc ttt gtc aac      144
 Thr Gly Arg Ala Lys Arg Arg Met Gln Tyr Asn Arg Arg Phe Val Asn
          35                  40                  45

 gtt gtg ccc acc ttt ggc aag aag aag ggc acc acg ttc acc aag atc      192
 Val Val Pro Thr Phe Gly Lys Lys Lys Gly Thr Thr Phe Thr Lys Ile
      50                  55                  60

 ttc gtg ggc ggc ctg ccg tac cac act acc gac gcc tcg ctc agg aag      240
 Phe Val Gly Gly Leu Pro Tyr His Thr Thr Asp Ala Ser Leu Arg Lys
  65                  70                  75                  80

 tac ttc gag ggc ttc ggc gac atc gag gag gcc gtg gtc atc acc gac      288
 Tyr Phe Glu Gly Phe Gly Asp Ile Glu Glu Ala Val Val Ile Thr Asp
                  85                  90                  95

 cgc cag acg ggc aag tcc cgc ggc tac ggc ttc gtg acc atg gcc gac      336
 Arg Gln Thr Gly Lys Ser Arg Gly Tyr Gly Phe Val Thr Met Ala Asp
             100                 105                 110

 cgg gcg gca gct gag agg gct tgc aaa gac ccg aac ccc atc atc gac      384
 Arg Ala Ala Ala Glu Arg Ala Cys Lys Asp Pro Asn Pro Ile Ile Asp
         115                 120                 125

 ggc cgc aag gcc aac gtg aac ctg gca tat ctg ggc gcc aag ccg cgg      432
 Gly Arg Lys Ala Asn Val Asn Leu Ala Tyr Leu Gly Ala Lys Pro Arg
     130                 135                 140

 agc ctc cag acg ggc ttt gcc att ggg gtg cag cag ctg cac ccc acc      480
 Ser Leu Gln Thr Gly Phe Ala Ile Gly Val Gln Gln Leu His Pro Thr
 145                 150                 155                 160

 ttg atc cag cgg act tac ggg ctg acc ccg cac tac atc tac cca cca      528
 Leu Ile Gln Arg Thr Tyr Gly Leu Thr Pro His Tyr Ile Tyr Pro Pro
                 165                 170                 175

 gcc atc gtg cag ccc agc gtg gtg atc cca gcc gcc cct gtc ccg tcg      576
 Ala Ile Val Gln Pro Ser Val Val Ile Pro Ala Ala Pro Val Pro Ser
             180                 185                 190

 ctg tcc tcg ccc tac att gag tac acg ccg gcc agc ccg gcc tac gcc      624
 Leu Ser Ser Pro Tyr Ile Glu Tyr Thr Pro Ala Ser Pro Ala Tyr Ala
         195                 200                 205

 cag tac cca ccg gcc acc tat gac cag tac cca tac gcc gcc tcg cct      672
 Gln Tyr Pro Pro Ala Thr Tyr Asp Gln Tyr Pro Tyr Ala Ala Ser Pro
     210                 215                 220

 gcc acg gct gcc agc ttc gtg ggc tac agc tac cct gcc gcc gtg ccc      720
 Ala Thr Ala Ala Ser Phe Val Gly Tyr Ser Tyr Pro Ala Ala Val Pro
 225                 230                 235                 240

 cag gcc ctc tca gcc gca gca ccc gcg ggc acc act ttc gtg cag tac      768
 Gln Ala Leu Ser Ala Ala Ala Pro Ala Gly Thr Thr Phe Val Gln Tyr
                 245                 250                 255

 cag gcg ccg cag ctg cag cct gac agg atg cag tga                      804
 Gln Ala Pro Gln Leu Gln Pro Asp Arg Met Gln 
             260                 265





      <210> 281
      <211> 1203
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (297)..(815)

      <400> 281
 ccatctacaa ggtttgcgaa cccatgttgc cgattttttt tttctgctac agaacaactc     60

 ccttggtaca ataaaaaaga cgagtattta cttttcattg aaagtggaga acctgaaaag    120

 gaacctggaa agaagcagct ggaaaaggtg agaggaaaac ctagagtgtg tgttatcctg    180

 caagccaatt gagaatggag cttgcttgat atttcactag ataaagaatt taaggcgagt    240

 atctatcttt gttctccttg gcaactgaga gtctgccctt ggaaacatca ggcacc        296                                                                 
 atg ggg aag cgg gat aat cgg gta gcc tat atg aat cct ata gca atg      344
 Met Gly Lys Arg Asp Asn Arg Val Ala Tyr Met Asn Pro Ile Ala Met
   1               5                  10                  15

 gcc aga tgg aga ggc cca act caa tct gtg ggc cca aca atc caa gat      392
 Ala Arg Trp Arg Gly Pro Thr Gln Ser Val Gly Pro Thr Ile Gln Asp
              20                  25                  30

 tat cta aat cga cca aga ccc acc tgg gaa gaa gta aag aaa caa tta      440
 Tyr Leu Asn Arg Pro Arg Pro Thr Trp Glu Glu Val Lys Lys Gln Leu
          35                  40                  45

 gaa aat aaa aaa aaa ggc tcc aaa gca tta gct gaa ttt gaa gaa aaa      488
 Glu Asn Lys Lys Lys Gly Ser Lys Ala Leu Ala Glu Phe Glu Glu Lys
      50                  55                  60

 atg aat gaa aat tgg aag aaa gaa ctt gaa aaa agc aga gag aaa tta      536
 Met Asn Glu Asn Trp Lys Lys Glu Leu Glu Lys Ser Arg Glu Lys Leu
  65                  70                  75                  80

 tta agt gga aat gag agc tca tct aaa aaa aga gaa aga aag aaa aag      584
 Leu Ser Gly Asn Glu Ser Ser Ser Lys Lys Arg Glu Arg Lys Lys Lys
                  85                  90                  95

 aga aag aag aaa tct tgt cgg tct tca tct tct tca tca agc tct gat      632
 Arg Lys Lys Lys Ser Cys Arg Ser Ser Ser Ser Ser Ser Ser Ser Asp
             100                 105                 110

 tct tca agc agt tct tca gat tct gag gat gag gaa aag aaa caa gga      680
 Ser Ser Ser Ser Ser Ser Asp Ser Glu Asp Glu Glu Lys Lys Gln Gly
         115                 120                 125

 aaa agg aga aag aaa aag aag aac cgt tca tac aaa tca tcc caa agc      728
 Lys Arg Arg Lys Lys Lys Lys Asn Arg Ser Tyr Lys Ser Ser Gln Ser
     130                 135                 140

 tct acg cat gaa tca gaa tca gag agc aag gag tct gta aaa aga aaa      776
 Ser Thr His Glu Ser Glu Ser Glu Ser Lys Glu Ser Val Lys Arg Lys
 145                 150                 155                 160

 aga agt caa agg atg aaa cag aga aag aaa agg atg taa gaagcctcag       825
 Arg Ser Gln Arg Met Lys Gln Arg Lys Lys Arg Met 
                 165                 170

 caaaaaaaga aagaaaagtt accctgatga taaaccttta tcatctgagt cctcatctga    885

 atcagattat gaagaggatg tgcaagcaaa aaagaagaga aggtgtgaag agcgagaaca    945

 agcaaaggaa aaagtaaaga agaagaagaa gaaacagcac aagaaacata gtaagaagaa   1005

 gaaaaagaag tctggatcaa gtcacaagtc aaggtaacat caagaaaaaa agcaagaatg   1065

 agtttgccga gttccccgtg tgttagtaga attatttctg gactttgagt tgcctatcaa   1125

 atcccactgt gccagtaagg ggcatagtgg ctgctggcaa cttcaatata catttttgtt   1185

 tgtttgcttg ttccgctg                                                 1203




      <210> 282
      <211> 1430
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (147)..(1229)

      <400> 282
 aaaccactct aagtgtgacc actctaaagc attagcaatc agtcatttca ctctagggag     60

 aaatcagagc tgaaatatag aggataggta aagtccccaa tgtagatatg tatttttata    120

 tttgtttact tgcttttttt tgttag atg caa ata ata cgg cac tcc gaa cag     173
                              Met Gln Ile Ile Arg His Ser Glu Gln
                                1               5

 aca cta aaa aca gct ctc atc tca aag aac cca gtg ctt gta tca cag      221
 Thr Leu Lys Thr Ala Leu Ile Ser Lys Asn Pro Val Leu Val Ser Gln
  10                  15                  20                  25

 tat gag aaa tta gat gct ggg gaa caa cgt tta atg aat gaa gcc ttc      269
 Tyr Glu Lys Leu Asp Ala Gly Glu Gln Arg Leu Met Asn Glu Ala Phe
                  30                  35                  40

 cag cca gcc agt gat ctc ttt gga ccc att acc ttg cat tct cca tca      317
 Gln Pro Ala Ser Asp Leu Phe Gly Pro Ile Thr Leu His Ser Pro Ser
              45                  50                  55

 gat tgg atc acc tcc cac cct gag gct ccc caa gac ttt gaa cag ttc      365
 Asp Trp Ile Thr Ser His Pro Glu Ala Pro Gln Asp Phe Glu Gln Phe
          60                  65                  70

 ttc agt gat cct tac aga aag aca ccc tct cca aac aaa cgc agc att      413
 Phe Ser Asp Pro Tyr Arg Lys Thr Pro Ser Pro Asn Lys Arg Ser Ile
      75                  80                  85

 tat ata cag tcc att ggc tct cta gga aac acc aga att atc agt gaa      461
 Tyr Ile Gln Ser Ile Gly Ser Leu Gly Asn Thr Arg Ile Ile Ser Glu
  90                  95                 100                 105

 gaa tat att aaa tgg ctc acg ggc tac tgt aaa gca tat ttc tat ggc      509
 Glu Tyr Ile Lys Trp Leu Thr Gly Tyr Cys Lys Ala Tyr Phe Tyr Gly
                 110                 115                 120

 ttg aga gta aaa ctc cta gaa cca gtt cct gtt tct gta aca aga tgt      557
 Leu Arg Val Lys Leu Leu Glu Pro Val Pro Val Ser Val Thr Arg Cys
             125                 130                 135

 tcc ttt aga gtc aat gag aac aca cac aac cta caa att cat gca ggg      605
 Ser Phe Arg Val Asn Glu Asn Thr His Asn Leu Gln Ile His Ala Gly
         140                 145                 150

 gac atc ctg aag ttc ttg aaa aag aag aaa cct gaa gat gcc ttc tgt      653
 Asp Ile Leu Lys Phe Leu Lys Lys Lys Lys Pro Glu Asp Ala Phe Cys
     155                 160                 165

 gtt gtg gga ata aca atg att gat ctt tac cca aga gac tcg tgg aat      701
 Val Val Gly Ile Thr Met Ile Asp Leu Tyr Pro Arg Asp Ser Trp Asn
 170                 175                 180                 185

 ttt gtc ttt gga cag gcc tct ttg aca gat ggt gtg ggg ata ttc agc      749
 Phe Val Phe Gly Gln Ala Ser Leu Thr Asp Gly Val Gly Ile Phe Ser
                 190                 195                 200

 ttt gcc agg tat ggc agt gat ttt tat agc atg cac tat aaa ggc aaa      797
 Phe Ala Arg Tyr Gly Ser Asp Phe Tyr Ser Met His Tyr Lys Gly Lys
             205                 210                 215

 gtg aag aag ctc aag aaa aca tct tca agt gac tat tca att ttc gac      845
 Val Lys Lys Leu Lys Lys Thr Ser Ser Ser Asp Tyr Ser Ile Phe Asp
         220                 225                 230

 aac tat tat att cca gaa ata act agt gtt tta cta ctt cga tcc tgt      893
 Asn Tyr Tyr Ile Pro Glu Ile Thr Ser Val Leu Leu Leu Arg Ser Cys
     235                 240                 245

 aag act tta acc cat gag atc gga cac ata ttt gga ctg cga cac tgc      941
 Lys Thr Leu Thr His Glu Ile Gly His Ile Phe Gly Leu Arg His Cys
 250                 255                 260                 265

 cag tgg ctt gca tgc ctc atg caa ggc tcc aac cac ttg gaa gaa gct      989
 Gln Trp Leu Ala Cys Leu Met Gln Gly Ser Asn His Leu Glu Glu Ala
                 270                 275                 280

 gac cgg cgc cct cta aac ctt tgc cct atc tgt ttg cac aag ttg cag     1037
 Asp Arg Arg Pro Leu Asn Leu Cys Pro Ile Cys Leu His Lys Leu Gln
             285                 290                 295

 tgt gct gtt ggc ttc agc att gta gaa aga tac aaa gca ctg gtg agg     1085
 Cys Ala Val Gly Phe Ser Ile Val Glu Arg Tyr Lys Ala Leu Val Arg
         300                 305                 310

 tgg att gat gat gaa tct tct gac aca cct gga gca act cca gaa cac     1133
 Trp Ile Asp Asp Glu Ser Ser Asp Thr Pro Gly Ala Thr Pro Glu His
     315                 320                 325

 agt cac gag gat aat ggg aat tta ccg aaa ccc gtg gaa gcc ttt aag     1181
 Ser His Glu Asp Asn Gly Asn Leu Pro Lys Pro Val Glu Ala Phe Lys
 330                 335                 340                 345

 gaa tgg aaa gag tgg ata ata aaa tgc ctg gct gtt ctc caa aaa tga     1229
 Glu Trp Lys Glu Trp Ile Ile Lys Cys Leu Ala Val Leu Gln Lys 
                 350                 355                 360

 ggaccttcaa ataggagtga ttgaaataaa taactacttg catgttatgc tttcatttgg   1289

 gtggaatact tcattggaat aaactactga tcttgtgctg tgtcaaagta acagactaga   1349

 accttctttc aagtacctga attgaaatga aactcatttt gaataataaa aactctagaa   1409

 actcaaaaaa aaaaaaaaaa g                                             1430




      <210> 283
      <211> 4651
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (180)..(4601)

      <400> 283
 cccaggagac tggagagagg ttaaacaaat acaaagagga acaccgtcga attcttcaag     60

 aaagtattga tgttgctccc tttacaacta aaatcaaggg acttgagggt gagagagaga    120

 attattccag agtggcatca tcatcttcca gtcctaaaag ccatatcatc aaacaagat     179                                                                 
 atg gat gta gaa cgc tca gta tca gat ctt tat aaa atg aag cac tca      227
 Met Asp Val Glu Arg Ser Val Ser Asp Leu Tyr Lys Met Lys His Ser
   1               5                  10                  15

 gtg cct cag agt tta ccc caa agt aac tat ttc act aca ttg tct aat      275
 Val Pro Gln Ser Leu Pro Gln Ser Asn Tyr Phe Thr Thr Leu Ser Asn
              20                  25                  30

 agt gtg gtc aat gaa cca cca aga tca tac cca tcc aaa gaa gtt tca      323
 Ser Val Val Asn Glu Pro Pro Arg Ser Tyr Pro Ser Lys Glu Val Ser
          35                  40                  45

 aat att tac ggt gat aaa cag agt aat gcc ctt gca gcg gca gca gct      371
 Asn Ile Tyr Gly Asp Lys Gln Ser Asn Ala Leu Ala Ala Ala Ala Ala
      50                  55                  60

 aat cct caa act ctg act tca ttt ata aca tct ctt tca aag cct cca      419
 Asn Pro Gln Thr Leu Thr Ser Phe Ile Thr Ser Leu Ser Lys Pro Pro
  65                  70                  75                  80

 cct ttg att aaa cac caa cca gaa agt gaa ggt tta gta ggc aag ata      467
 Pro Leu Ile Lys His Gln Pro Glu Ser Glu Gly Leu Val Gly Lys Ile
                  85                  90                  95

 cca gaa cat ctt cca cat cag att gca tct cac tca gta aca acc ttc      515
 Pro Glu His Leu Pro His Gln Ile Ala Ser His Ser Val Thr Thr Phe
             100                 105                 110

 aga aat gat tgt agg agt cct acc cat ttg aca gtt tct tct aca aat      563
 Arg Asn Asp Cys Arg Ser Pro Thr His Leu Thr Val Ser Ser Thr Asn
         115                 120                 125

 aca ctc cgc agt atg cct gca tta cat aga gca cca gta ttt cac cca      611
 Thr Leu Arg Ser Met Pro Ala Leu His Arg Ala Pro Val Phe His Pro
     130                 135                 140

 cca atc cat cac agc ctg gaa aga aag gaa ggc agc tat agt agt ctt      659
 Pro Ile His His Ser Leu Glu Arg Lys Glu Gly Ser Tyr Ser Ser Leu
 145                 150                 155                 160

 tcc cct cca act tta act ccg gtg atg cca gta aat gct ggt ggt aaa      707
 Ser Pro Pro Thr Leu Thr Pro Val Met Pro Val Asn Ala Gly Gly Lys
                 165                 170                 175

 gtt caa gaa tca cag aag cct cca act cta ata ccc gaa cca aaa gac      755
 Val Gln Glu Ser Gln Lys Pro Pro Thr Leu Ile Pro Glu Pro Lys Asp
             180                 185                 190

 tcc cag gca aat ttt aag agt tct tca gaa cag agt ttg acg gag atg      803
 Ser Gln Ala Asn Phe Lys Ser Ser Ser Glu Gln Ser Leu Thr Glu Met
         195                 200                 205

 tgg aga cct aat aat aac ctc agc aaa gag aaa act gaa tgg cat gtg      851
 Trp Arg Pro Asn Asn Asn Leu Ser Lys Glu Lys Thr Glu Trp His Val
     210                 215                 220

 gag aaa agc agc gga aag tta cag gct gct atg gca tct gtc att gtg      899
 Glu Lys Ser Ser Gly Lys Leu Gln Ala Ala Met Ala Ser Val Ile Val
 225                 230                 235                 240

 cgt cca tct tct agt aca aaa act gat agt atg cca gca atg cag tta      947
 Arg Pro Ser Ser Ser Thr Lys Thr Asp Ser Met Pro Ala Met Gln Leu
                 245                 250                 255

 gct tct aaa gat cga gtt agt gaa aga tct tca gct ggg gca cat aaa      995
 Ala Ser Lys Asp Arg Val Ser Glu Arg Ser Ser Ala Gly Ala His Lys
             260                 265                 270

 aca gat tgc ctc aaa cta gca gaa gcc gga gaa act gga aga atc att     1043
 Thr Asp Cys Leu Lys Leu Ala Glu Ala Gly Glu Thr Gly Arg Ile Ile
         275                 280                 285

 ttg cca aat gtg aat tca gac agt gtt cac aca aaa tct gaa aaa aac     1091
 Leu Pro Asn Val Asn Ser Asp Ser Val His Thr Lys Ser Glu Lys Asn
     290                 295                 300

 ttt cag gct gtc tca cag ggc agt gtt ccc agt tca gtc atg tct gct     1139
 Phe Gln Ala Val Ser Gln Gly Ser Val Pro Ser Ser Val Met Ser Ala
 305                 310                 315                 320

 gta aat acg atg tgt aat acc aaa acg gat gta atc aca tct gct gcc     1187
 Val Asn Thr Met Cys Asn Thr Lys Thr Asp Val Ile Thr Ser Ala Ala
                 325                 330                 335

 gat act acc agt gtt tcc agc tgg ggt ggt tca gaa gta att tcc tct     1235
 Asp Thr Thr Ser Val Ser Ser Trp Gly Gly Ser Glu Val Ile Ser Ser
             340                 345                 350

 tta tca aat acc att ttg gcc tct aca tca tca gaa tgt gta tct tca     1283
 Leu Ser Asn Thr Ile Leu Ala Ser Thr Ser Ser Glu Cys Val Ser Ser
         355                 360                 365

 aaa agt gtc agt cag cca gtg gct caa aaa caa gaa tgc aag gtc agc     1331
 Lys Ser Val Ser Gln Pro Val Ala Gln Lys Gln Glu Cys Lys Val Ser
     370                 375                 380

 acc aca gca cca gtt aca tta gcc agt agt aag aca gga agt gtt gtt     1379
 Thr Thr Ala Pro Val Thr Leu Ala Ser Ser Lys Thr Gly Ser Val Val
 385                 390                 395                 400

 caa ccc agt tct ggg ttc tca ggc aca act gat ttt atc cat tta aaa     1427
 Gln Pro Ser Ser Gly Phe Ser Gly Thr Thr Asp Phe Ile His Leu Lys
                 405                 410                 415

 aag cac aag gca gca ttg gct gca gct cag tat aaa agt agt aat gcc     1475
 Lys His Lys Ala Ala Leu Ala Ala Ala Gln Tyr Lys Ser Ser Asn Ala
             420                 425                 430

 agt gag act gaa cct aat gct ata aaa aat cag aca ctt tca gcc tcc     1523
 Ser Glu Thr Glu Pro Asn Ala Ile Lys Asn Gln Thr Leu Ser Ala Ser
         435                 440                 445

 ctt cct ctg gat agc act gta atc tgt agt aca att aac aaa gca aac     1571
 Leu Pro Leu Asp Ser Thr Val Ile Cys Ser Thr Ile Asn Lys Ala Asn
     450                 455                 460

 tct gta gga aat ggg caa gct tcc cag aca agt caa cca aac tac cat     1619
 Ser Val Gly Asn Gly Gln Ala Ser Gln Thr Ser Gln Pro Asn Tyr His
 465                 470                 475                 480

 act aaa ctg aaa aag gcc tgg ctc acc aga cac tca gaa gaa gat aaa     1667
 Thr Lys Leu Lys Lys Ala Trp Leu Thr Arg His Ser Glu Glu Asp Lys
                 485                 490                 495

 aat act aat aaa atg gaa aat tca ggg aat tct gta tca gaa att att     1715
 Asn Thr Asn Lys Met Glu Asn Ser Gly Asn Ser Val Ser Glu Ile Ile
             500                 505                 510

 aag cca tgt tct gtc aac tta ata gcc tct aca tct agt gat ata caa     1763
 Lys Pro Cys Ser Val Asn Leu Ile Ala Ser Thr Ser Ser Asp Ile Gln
         515                 520                 525

 aat agt gta gat agt aag atc ata gtt gat aaa tat gta aaa gat gat     1811
 Asn Ser Val Asp Ser Lys Ile Ile Val Asp Lys Tyr Val Lys Asp Asp
     530                 535                 540

 aaa gtc aac agg aga aaa gcc aaa aga act tat gaa tct ggc tct gaa     1859
 Lys Val Asn Arg Arg Lys Ala Lys Arg Thr Tyr Glu Ser Gly Ser Glu
 545                 550                 555                 560

 agt gga gac tca gat gaa agt gaa agc aag tca gag caa agg act aaa     1907
 Ser Gly Asp Ser Asp Glu Ser Glu Ser Lys Ser Glu Gln Arg Thr Lys
                 565                 570                 575

 aga caa cct aag cca act tac aaa aag aag caa aat gat ttg caa aag     1955
 Arg Gln Pro Lys Pro Thr Tyr Lys Lys Lys Gln Asn Asp Leu Gln Lys
             580                 585                 590

 aga aaa ggt gaa ata gaa gaa gat ttg aaa ccc aat gga gtt ctc agc     2003
 Arg Lys Gly Glu Ile Glu Glu Asp Leu Lys Pro Asn Gly Val Leu Ser
         595                 600                 605

 agg agt gcc aaa gaa aga agt aaa ctg aag ttg caa agc aac agt aat     2051
 Arg Ser Ala Lys Glu Arg Ser Lys Leu Lys Leu Gln Ser Asn Ser Asn
     610                 615                 620

 act ggc att cct cgt tca gta ttg aaa gat tgg cgt aaa gtc aag aag     2099
 Thr Gly Ile Pro Arg Ser Val Leu Lys Asp Trp Arg Lys Val Lys Lys
 625                 630                 635                 640

 ctg aag caa act ggg gaa tcc ttt tta cag gat gac tcc tgc tgt gag     2147
 Leu Lys Gln Thr Gly Glu Ser Phe Leu Gln Asp Asp Ser Cys Cys Glu
                 645                 650                 655

 ata ggg cct aat tta caa aag tgt cga gaa tgt aga ctt att cgc agt     2195
 Ile Gly Pro Asn Leu Gln Lys Cys Arg Glu Cys Arg Leu Ile Arg Ser
             660                 665                 670

 aaa aaa gga gaa gaa cca gct cac tca cca gta ttt tgt aga ttt tac     2243
 Lys Lys Gly Glu Glu Pro Ala His Ser Pro Val Phe Cys Arg Phe Tyr
         675                 680                 685

 tac ttt aga cgg ttg tca ttt agt aaa aac gga gta gtt aga ata gat     2291
 Tyr Phe Arg Arg Leu Ser Phe Ser Lys Asn Gly Val Val Arg Ile Asp
     690                 695                 700

 ggt ttc tct tct cct gac caa tat gat gat gaa gct atg agt ttg tgg     2339
 Gly Phe Ser Ser Pro Asp Gln Tyr Asp Asp Glu Ala Met Ser Leu Trp
 705                 710                 715                 720

 aca cat gaa aat ttt gaa gat gat gaa cta gat ata gag act tct aaa     2387
 Thr His Glu Asn Phe Glu Asp Asp Glu Leu Asp Ile Glu Thr Ser Lys
                 725                 730                 735

 tat atc ttg gat ata ata ggt gat aag ttc tgt caa tta gta aca tct     2435
 Tyr Ile Leu Asp Ile Ile Gly Asp Lys Phe Cys Gln Leu Val Thr Ser
             740                 745                 750

 gaa aaa aca gct ttg tcc tgg gtg aaa aag gat gcc aaa att gcc tgg     2483
 Glu Lys Thr Ala Leu Ser Trp Val Lys Lys Asp Ala Lys Ile Ala Trp
         755                 760                 765

 aaa aga gca gtg aga gga gtc cgg gag atg tgt gat gca tgt gaa gca     2531
 Lys Arg Ala Val Arg Gly Val Arg Glu Met Cys Asp Ala Cys Glu Ala
     770                 775                 780

 aca ttg ttt aac att cac tgg gtc tgc caa aaa tgt gga ttt gtg gtc     2579
 Thr Leu Phe Asn Ile His Trp Val Cys Gln Lys Cys Gly Phe Val Val
 785                 790                 795                 800

 tgc tta gat tgt tac aag gca aag gaa agg aag agt tct aga gat aaa     2627
 Cys Leu Asp Cys Tyr Lys Ala Lys Glu Arg Lys Ser Ser Arg Asp Lys
                 805                 810                 815

 gaa cta tat gct tgg atg aag tgt gtg aag gga cag cct cat gat cac     2675
 Glu Leu Tyr Ala Trp Met Lys Cys Val Lys Gly Gln Pro His Asp His
             820                 825                 830

 aaa cat tta atg cca acc caa att ata cct ggt tct gtt ttg aca gat     2723
 Lys His Leu Met Pro Thr Gln Ile Ile Pro Gly Ser Val Leu Thr Asp
         835                 840                 845

 ctt cta gat gcc atg cac act ctt agg gaa aaa tat ggt att aaa tcc     2771
 Leu Leu Asp Ala Met His Thr Leu Arg Glu Lys Tyr Gly Ile Lys Ser
     850                 855                 860

 cat tgt cat tgt act aac aaa cag aat tta caa gtt gga aat ttt cct     2819
 His Cys His Cys Thr Asn Lys Gln Asn Leu Gln Val Gly Asn Phe Pro
 865                 870                 875                 880

 aca atg aat ggt gta tct caa gtt tta cag aat gtt ctt aat cac agt     2867
 Thr Met Asn Gly Val Ser Gln Val Leu Gln Asn Val Leu Asn His Ser
                 885                 890                 895

 aat aaa att tct ctg tgc atg cct gag tct cag cag caa aat act cct     2915
 Asn Lys Ile Ser Leu Cys Met Pro Glu Ser Gln Gln Gln Asn Thr Pro
             900                 905                 910

 ccg aag tct gag aaa aat ggt ggc agc agc cca gag agt gat gta ggc     2963
 Pro Lys Ser Glu Lys Asn Gly Gly Ser Ser Pro Glu Ser Asp Val Gly
         915                 920                 925

 aca gat aac aag tta act cct cca gaa tcc cag tca cca ctg cac tgg     3011
 Thr Asp Asn Lys Leu Thr Pro Pro Glu Ser Gln Ser Pro Leu His Trp
     930                 935                 940

 tta gca gat ctt gca gag caa aaa gcc aga gag gaa aaa aaa gaa aac     3059
 Leu Ala Asp Leu Ala Glu Gln Lys Ala Arg Glu Glu Lys Lys Glu Asn
 945                 950                 955                 960

 aaa gaa ctt acc ctt gaa aac caa att aaa gaa gaa aga gaa caa gac     3107
 Lys Glu Leu Thr Leu Glu Asn Gln Ile Lys Glu Glu Arg Glu Gln Asp
                 965                 970                 975

 aac tct gaa tct cca aat ggc aga aca tca cct ctt gtg tcc cag aat     3155
 Asn Ser Glu Ser Pro Asn Gly Arg Thr Ser Pro Leu Val Ser Gln Asn
             980                 985                 990

 aat gaa caa ggc tca acc tta cgg gat ttg ctg act aca aca gct gga     3203
 Asn Glu Gln Gly Ser Thr Leu Arg Asp Leu Leu Thr Thr Thr Ala Gly
         995                1000                1005

 aag cta cgt gtg ggg tct aca gat gct ggc att gcc ttt gcc cca gta     3251
 Lys Leu Arg Val Gly Ser Thr Asp Ala Gly Ile Ala Phe Ala Pro Val
    1010                1015                1020

 tat tca atg gga gcc cca agt agc aaa agt gga cgg act atg cct aac     3299
 Tyr Ser Met Gly Ala Pro Ser Ser Lys Ser Gly Arg Thr Met Pro Asn
1025                1030                1035                1040

 att ctt gat gac ata att gct tca gtt gtt gaa aac aaa att cca cca     3347
 Ile Leu Asp Asp Ile Ile Ala Ser Val Val Glu Asn Lys Ile Pro Pro
                1045                1050                1055

 agt aaa acc tcc aag ata aat gta aaa cca gag ctt aaa gaa gag cct     3395
 Ser Lys Thr Ser Lys Ile Asn Val Lys Pro Glu Leu Lys Glu Glu Pro
            1060                1065                1070

 gaa gaa agc ata ata tct gca gtg gat gaa aat aat aaa tta tac agt     3443
 Glu Glu Ser Ile Ile Ser Ala Val Asp Glu Asn Asn Lys Leu Tyr Ser
        1075                1080                1085

 gat ata cca cat tct tgg atc tgt gag aag cat att tta tgg ctt aag     3491
 Asp Ile Pro His Ser Trp Ile Cys Glu Lys His Ile Leu Trp Leu Lys
    1090                1095                1100

 gat tat aag aat agc agt aat tgg aag ctt ttc aaa gaa tgt tgg aaa     3539
 Asp Tyr Lys Asn Ser Ser Asn Trp Lys Leu Phe Lys Glu Cys Trp Lys
1105                1110                1115                1120

 caa gga cag cct gca gtg gtt tct ggt gtg cat aag aaa atg aac att     3587
 Gln Gly Gln Pro Ala Val Val Ser Gly Val His Lys Lys Met Asn Ile
                1125                1130                1135

 agc cta tgg aag gcg gaa tca att agt ctt gat ttt gga gac cac caa     3635
 Ser Leu Trp Lys Ala Glu Ser Ile Ser Leu Asp Phe Gly Asp His Gln
            1140                1145                1150

 gct gat ctc ctg aac tgc aaa gat agc atc att tca aat gcc aat gtt     3683
 Ala Asp Leu Leu Asn Cys Lys Asp Ser Ile Ile Ser Asn Ala Asn Val
        1155                1160                1165

 aag gaa ttc tgg gat ggt ttt gaa gaa gtt tca aaa cgg cag aaa aac     3731
 Lys Glu Phe Trp Asp Gly Phe Glu Glu Val Ser Lys Arg Gln Lys Asn
    1170                1175                1180

 aag agt gga gaa aca gtt gtt tta aaa ttg aaa gat tgg cct tca gga     3779
 Lys Ser Gly Glu Thr Val Val Leu Lys Leu Lys Asp Trp Pro Ser Gly
1185                1190                1195                1200

 gaa gac ttc aag act atg atg cca gca aga tac gaa gat ctt tta aaa     3827
 Glu Asp Phe Lys Thr Met Met Pro Ala Arg Tyr Glu Asp Leu Leu Lys
                1205                1210                1215

 agt ctg cca ttg cca gaa tat tgt aat cca gaa gga aaa ttc aat ttg     3875
 Ser Leu Pro Leu Pro Glu Tyr Cys Asn Pro Glu Gly Lys Phe Asn Leu
            1220                1225                1230

 gcc tct cat ttg cca gga ttt ttt gta cgt cct gat cta gga ccc agg     3923
 Ala Ser His Leu Pro Gly Phe Phe Val Arg Pro Asp Leu Gly Pro Arg
        1235                1240                1245

 ttg tgc agt gcc tat ggt gta gtt gct gct aaa gat cat gat ata gga     3971
 Leu Cys Ser Ala Tyr Gly Val Val Ala Ala Lys Asp His Asp Ile Gly
    1250                1255                1260

 aca aca aat ctc cat att gaa gtt tct gat gtt gta aat ata cta gtt     4019
 Thr Thr Asn Leu His Ile Glu Val Ser Asp Val Val Asn Ile Leu Val
1265                1270                1275                1280

 tat gtt ggc ata gca aaa gga aat ggc att ctc tca aaa gca gga att     4067
 Tyr Val Gly Ile Ala Lys Gly Asn Gly Ile Leu Ser Lys Ala Gly Ile
                1285                1290                1295

 ctc aag aaa ttt gag gaa gaa gat ttg gat gac att tta agg aaa aga     4115
 Leu Lys Lys Phe Glu Glu Glu Asp Leu Asp Asp Ile Leu Arg Lys Arg
            1300                1305                1310

 ttg aag gac tca agt gaa ata cct ggt gct ctg tgg cat att tat gct     4163
 Leu Lys Asp Ser Ser Glu Ile Pro Gly Ala Leu Trp His Ile Tyr Ala
        1315                1320                1325

 ggg aaa gat gtt gac aag ata agg gaa ttt ctt caa aag att tca aaa     4211
 Gly Lys Asp Val Asp Lys Ile Arg Glu Phe Leu Gln Lys Ile Ser Lys
    1330                1335                1340

 gaa caa ggc ctt gaa gtt cta cca gaa cat gat cca ata cgt gac caa     4259
 Glu Gln Gly Leu Glu Val Leu Pro Glu His Asp Pro Ile Arg Asp Gln
1345                1350                1355                1360

 agt tgg tat gtg aac aaa aag ctc cgt caa agg ctg ctt gaa gaa tat     4307
 Ser Trp Tyr Val Asn Lys Lys Leu Arg Gln Arg Leu Leu Glu Glu Tyr
                1365                1370                1375

 gga gtc aga acc tgt act ctt att cag ttc ctt ggt gat gct att gtt     4355
 Gly Val Arg Thr Cys Thr Leu Ile Gln Phe Leu Gly Asp Ala Ile Val
            1380                1385                1390

 ttg cca gcg gga gca ctt cat cag gtt cag aat ttt cac agc tgt att     4403
 Leu Pro Ala Gly Ala Leu His Gln Val Gln Asn Phe His Ser Cys Ile
        1395                1400                1405

 cag gta act gaa gat ttt gtg tct cca gaa cat ctt gta gag tca ttt     4451
 Gln Val Thr Glu Asp Phe Val Ser Pro Glu His Leu Val Glu Ser Phe
    1410                1415                1420

 cat tta aca cag gaa ctg aga ctt ttg aag gaa gaa atc aat tat gat     4499
 His Leu Thr Gln Glu Leu Arg Leu Leu Lys Glu Glu Ile Asn Tyr Asp
1425                1430                1435                1440

 gat aaa cta cag gtt aaa aat att ttg tat cat gca gtc aaa gaa atg     4547
 Asp Lys Leu Gln Val Lys Asn Ile Leu Tyr His Ala Val Lys Glu Met
                1445                1450                1455

 gtg aga gcc ttg aag ata cac gag gat gaa gta gag gat atg gaa gaa     4595
 Val Arg Ala Leu Lys Ile His Glu Asp Glu Val Glu Asp Met Glu Glu
            1460                1465                1470

 aat taa gtgtgatcca gtttgatatt tttaggttgt tgaactggga ttacttaacc      4651
 Asn 






      <210> 284
      <211> 1264
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (282)..(944)

      <400> 284
 catttggccc tgcttcaggt tctatgcact gatccagatg tttatgtgaa gcaaattacc     60

 aaaaccttga aaaataattt tccttcaaac atcagtccct atgtgtcatt tacatctaat    120

 tcttgggtat tttcaaggaa aagttcttgg ttggaatttg tcagattttg cattgggatt    180

 aaagctaatc agttttgcac acagccagct gtggtacaac acatgaaatt tcctcttcgg    240

 actgtcattt ccagcaaatg tccttcattt cctttgctct g    atg ccc cat ccc     293
                                                  Met Pro His Pro
                                                    1

 tct gtt agg ggc tat cgt ttg gga gca atg agt tta aaa ccc ttt acc      341
 Ser Val Arg Gly Tyr Arg Leu Gly Ala Met Ser Leu Lys Pro Phe Thr
   5                  10                  15                  20

 tac ccg ttt cca gag acg agg ttt ctt cat gca gga ccc aat gtg tat      389
 Tyr Pro Phe Pro Glu Thr Arg Phe Leu His Ala Gly Pro Asn Val Tyr
                  25                  30                  35

 aaa ttc aaa atc aga tat ggg aag agt atc aga gga gaa gag ata gaa      437
 Lys Phe Lys Ile Arg Tyr Gly Lys Ser Ile Arg Gly Glu Glu Ile Glu
              40                  45                  50

 aat aag gaa gtc atc acc cag gag ctg gag cac cat ttt cca gat aaa      485
 Asn Lys Glu Val Ile Thr Gln Glu Leu Glu His His Phe Pro Asp Lys
          55                  60                  65

 agc aaa tgg gag aga gtt tcc cac ctg aaa ttc aaa cat ggg gaa att      533
 Ser Lys Trp Glu Arg Val Ser His Leu Lys Phe Lys His Gly Glu Ile
      70                  75                  80

 atc ttg atc ccc tac cca ttt gtt ttt act cta tat gtg gag atg aaa      581
 Ile Leu Ile Pro Tyr Pro Phe Val Phe Thr Leu Tyr Val Glu Met Lys
  85                  90                  95                 100

 tgg ttc cat gaa aac ctg tca cct ggt aag tgg aat gat gtg aat gtg      629
 Trp Phe His Glu Asn Leu Ser Pro Gly Lys Trp Asn Asp Val Asn Val
                 105                 110                 115

 gat ggc aga gaa gaa aat ggt tta gct gtg cca gct agg tat cgc gaa      677
 Asp Gly Arg Glu Glu Asn Gly Leu Ala Val Pro Ala Arg Tyr Arg Glu
             120                 125                 130

 agg ggc tac cag att agg ctc cag cca tac agt gca cag aat agg gaa      725
 Arg Gly Tyr Gln Ile Arg Leu Gln Pro Tyr Ser Ala Gln Asn Arg Glu
         135                 140                 145

 aga aaa acc caa caa gga ttg cag gag act ctg gcc tct gat atc act      773
 Arg Lys Thr Gln Gln Gly Leu Gln Glu Thr Leu Ala Ser Asp Ile Thr
     150                 155                 160

 gat gtc cag aaa caa gat tct gag tgg gga cac agc ctg cca ggg cga      821
 Asp Val Gln Lys Gln Asp Ser Glu Trp Gly His Ser Leu Pro Gly Arg
 165                 170                 175                 180

 att gtc cca ccc ctg cag cac aac tca cct cca cct aag gag cga gca      869
 Ile Val Pro Pro Leu Gln His Asn Ser Pro Pro Pro Lys Glu Arg Ala
                 185                 190                 195

 gcc acc ggc ttc ttt ggg ttt cta agc tct ctc ttc ccg ttt cga tat      917
 Ala Thr Gly Phe Phe Gly Phe Leu Ser Ser Leu Phe Pro Phe Arg Tyr
             200                 205                 210

 ttc ttc agg aag agc agc cac tct tga gcctt ccaaatgcag cgctggaaag      969
 Phe Phe Arg Lys Ser Ser His Ser 
         215                 220

 aggatcatct cttgtagtga ctcctcccga gccattcttc ctccaactct atccttttct   1029

 tatgacactt cagtcgtggg gaatgaggtc cccatgctga gtcctctgtg gttttatcgt   1089

 gtcctttgcc cctttataat agattttttc ccccaattta aaacattaag aatggaactt   1149

 tctaaaatgt tcatgtcctg agggccggtt taggcctttt gtcttcggca cttaggatcc   1209

 taatgacaat aaattattta tgaagagtta aaaaaaaaaa aaaaaaaaaa aattg        1264




      <210> 285
      <211> 593
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (270)..(593)

      <400> 285
 agcgcacctt ggtaatccgt gtcccgtcca ccctgtcctc tctgccctcc tctcgtgctt     60

 gcggctgcag cattgccgag caccttgtcc cgttgctttg tgtgtgccct tcttccaggg    120

 catgatccgt agggtcacat gtgtggctgc agtccgtgtc tctttgtgca tgcccaacac    180

 gaacgccact gtgctgccaa ctcagaaagc agctcttctt ggtgactgtg ggccgcatgc    240

 ctaaggaact taaagatgtg aagaaagac  atg tat gag caa aat gga aat acc     293
                                  Met Tyr Glu Gln Asn Gly Asn Thr
                                    1               5

 aat aat gag aca gaa aat cca aaa gga aac caa aca gaa aat atg aag      341
 Asn Asn Glu Thr Glu Asn Pro Lys Gly Asn Gln Thr Glu Asn Met Lys
      10                  15                  20

 ctg aaa agt aca ata aat gaa atg aaa aat tca cta aag gga ttc aaa      389
 Leu Lys Ser Thr Ile Asn Glu Met Lys Asn Ser Leu Lys Gly Phe Lys
  25                  30                  35                  40

 ggc aga tct gca cag gcg caa gaa aga atc agt gaa tgt gaa gac agg      437
 Gly Arg Ser Ala Gln Ala Gln Glu Arg Ile Ser Glu Cys Glu Asp Arg
                  45                  50                  55

 aca atg gga aat atc aag tat cca gaa cag aaa gaa aaa aga ttg aag      485
 Thr Met Gly Asn Ile Lys Tyr Pro Glu Gln Lys Glu Lys Arg Leu Lys
              60                  65                  70

 aaa agt gaa cag agc ctc agg gac ctt gtg gac atc atc aag cag gcc      533
 Lys Ser Glu Gln Ser Leu Arg Asp Leu Val Asp Ile Ile Lys Gln Ala
          75                  80                  85

 aac ata tgc tta gtg gga ctt tta gaa gga gaa gag aga aat ggg caa      581
 Asn Ile Cys Leu Val Gly Leu Leu Glu Gly Glu Glu Arg Asn Gly Gln
      90                  95                 100

 gac att att tga                                                      593
 Asp Ile Ile 
 105





      <210> 286
      <211> 5256
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (434)..(3712)

      <400> 286
 tcgggtaaaa gttccagaaa tgtgaagtac aaagattttt ttgatccagt tgaaagtgat     60

 gaagacatag caagtgatca tgatgatgat ctgggttcaa acaagtggat gaagttgctg    120

 aagaagcagc agaagaacta agcatttatg aaatgagtca gcttaagtag agctccgcgt    180

 gttggttgca gaagtcgcct gtcttccccg caggaggctg tttgctcgct ttgacactga    240

 atgctccccc aacaaacacg tttagcttgc ttgcccttct caccgactgc ggagaggagt    300

 ctcagtgcac agtcgcagag aaggcgtgcg ggggcgtgca ggggcgcaca ggcgcctgcc    360

 tctgcgggtg ggaaaggaag gaggtgcccg ggtttccgct cccagggctc agcctgcctt    420

 gggcacctac ggt   atg gga gcc ttt aac gtg gaa agg aaa gga gat cga     469
                  Met Gly Ala Phe Asn Val Glu Arg Lys Gly Asp Arg
                    1               5                  10

 tca ctc gag cct cca ctt gcc aag cct gtg gaa gcg aga cgc ggg gat      517
 Ser Leu Glu Pro Pro Leu Ala Lys Pro Val Glu Ala Arg Arg Gly Asp
          15                  20                  25

 cgg ctg gga atg cct gga agc gcc ggc gcg cgg agc cag gaa gaa gaa      565
 Arg Leu Gly Met Pro Gly Ser Ala Gly Ala Arg Ser Gln Glu Glu Glu
      30                  35                  40

 att gtc gag acg aat aac atg agg tca tat aga atc cca ctt ttg gtg      613
 Ile Val Glu Thr Asn Asn Met Arg Ser Tyr Arg Ile Pro Leu Leu Val
  45                  50                  55                  60

 att tca agt caa gaa agt aaa aaa cat cca gtt ttt cta ata ctc atg      661
 Ile Ser Ser Gln Glu Ser Lys Lys His Pro Val Phe Leu Ile Leu Met
                  65                  70                  75

 atg tca gaa ggg aaa cct cct gac aaa aaa agg cct cgt aga agc tta      709
 Met Ser Glu Gly Lys Pro Pro Asp Lys Lys Arg Pro Arg Arg Ser Leu
              80                  85                  90

 tca atc agc aag aat aag aaa aaa gca tct aat tct att att tcg tgt      757
 Ser Ile Ser Lys Asn Lys Lys Lys Ala Ser Asn Ser Ile Ile Ser Cys
          95                 100                 105

 ttt aac aat gca cca cct gct aaa ctt gcc tgc ccc gtt tgc agt aaa      805
 Phe Asn Asn Ala Pro Pro Ala Lys Leu Ala Cys Pro Val Cys Ser Lys
     110                 115                 120

 atg gtg cct aga tat gac tta aac cgg cac ctt gat gaa atg tgt gct      853
 Met Val Pro Arg Tyr Asp Leu Asn Arg His Leu Asp Glu Met Cys Ala
 125                 130                 135                 140

 aac aat gac ttc gtt caa gtg gat cca ggg cag gtt ggc tta ata aat      901
 Asn Asn Asp Phe Val Gln Val Asp Pro Gly Gln Val Gly Leu Ile Asn
                 145                 150                 155

 tca aat gtg tct atg gta gat tta acc agt gtt acc tta gaa gat gta      949
 Ser Asn Val Ser Met Val Asp Leu Thr Ser Val Thr Leu Glu Asp Val
             160                 165                 170

 aca cct aag aag tca cca cca cca aag aca aat tta acc cct ggc caa      997
 Thr Pro Lys Lys Ser Pro Pro Pro Lys Thr Asn Leu Thr Pro Gly Gln
         175                 180                 185

 agt gat tca gca aaa agg gaa gta aag cag aag atc agt ccc tac ttt     1045
 Ser Asp Ser Ala Lys Arg Glu Val Lys Gln Lys Ile Ser Pro Tyr Phe
     190                 195                 200

 aaa agt aat gat gtg gtg tgc aaa aat caa gat gag ctg aga aat cgt     1093
 Lys Ser Asn Asp Val Val Cys Lys Asn Gln Asp Glu Leu Arg Asn Arg
 205                 210                 215                 220

 agt gtg aaa gtc att tgt ttg gga agc cta gca tct aaa ttg tcc aga     1141
 Ser Val Lys Val Ile Cys Leu Gly Ser Leu Ala Ser Lys Leu Ser Arg
                 225                 230                 235

 aaa tac gta aag gct aaa aaa tca ata gat aag gat gaa gaa ttt gcc     1189
 Lys Tyr Val Lys Ala Lys Lys Ser Ile Asp Lys Asp Glu Glu Phe Ala
             240                 245                 250

 ggt tct agt cca cag agt tcc aaa tcc aca gtt gtt aag agc ctg att     1237
 Gly Ser Ser Pro Gln Ser Ser Lys Ser Thr Val Val Lys Ser Leu Ile
         255                 260                 265

 gat aac tct tca gaa att gag gac gag gat caa att ttg gag aac agt     1285
 Asp Asn Ser Ser Glu Ile Glu Asp Glu Asp Gln Ile Leu Glu Asn Ser
     270                 275                 280

 tct caa aaa gaa aac gtg ttt aaa tgt gat tct cta aag gaa gag tgc     1333
 Ser Gln Lys Glu Asn Val Phe Lys Cys Asp Ser Leu Lys Glu Glu Cys
 285                 290                 295                 300

 att cct gaa cat atg gta aga gga agt aaa ata atg gaa gcc gaa agc     1381
 Ile Pro Glu His Met Val Arg Gly Ser Lys Ile Met Glu Ala Glu Ser
                 305                 310                 315

 caa aag gct acc cgg gaa tgt gag aaa tca gcc ctc acc cct gga ttc     1429
 Gln Lys Ala Thr Arg Glu Cys Glu Lys Ser Ala Leu Thr Pro Gly Phe
             320                 325                 330

 tca gat aat gcg atc atg tta ttc tca cca gat ttc act ctt agg aat     1477
 Ser Asp Asn Ala Ile Met Leu Phe Ser Pro Asp Phe Thr Leu Arg Asn
         335                 340                 345

 aca tta aag tct act tca gaa gac agt ctt gta aag caa gag tgt atc     1525
 Thr Leu Lys Ser Thr Ser Glu Asp Ser Leu Val Lys Gln Glu Cys Ile
     350                 355                 360

 aaa gaa gtg gtt gaa aaa cgt gag gca tgt cat tgt gaa gaa gta aaa     1573
 Lys Glu Val Val Glu Lys Arg Glu Ala Cys His Cys Glu Glu Val Lys
 365                 370                 375                 380

 atg act gtt gct tca gaa gct aaa ata cag ctg tca gat tca gag gca     1621
 Met Thr Val Ala Ser Glu Ala Lys Ile Gln Leu Ser Asp Ser Glu Ala
                 385                 390                 395

 aaa tct cat agt tct gca gat gat gct tct gca tgg agt aac atc caa     1669
 Lys Ser His Ser Ser Ala Asp Asp Ala Ser Ala Trp Ser Asn Ile Gln
             400                 405                 410

 gag gct cct ctg cag gat gac agt tgc tta aac aat gat atc cct cac     1717
 Glu Ala Pro Leu Gln Asp Asp Ser Cys Leu Asn Asn Asp Ile Pro His
         415                 420                 425

 agc att cct ttg gag cag ggg tca agc tgc aat ggt cct ggt caa aca     1765
 Ser Ile Pro Leu Glu Gln Gly Ser Ser Cys Asn Gly Pro Gly Gln Thr
     430                 435                 440

 acc ggt cat cct tac tac ctt cgg agt ttc ctt gtg gtg ctg aaa acc     1813
 Thr Gly His Pro Tyr Tyr Leu Arg Ser Phe Leu Val Val Leu Lys Thr
 445                 450                 455                 460

 gta ctt gag aat gaa gat gat atg ttg ctc ttt gat gag cag gag aag     1861
 Val Leu Glu Asn Glu Asp Asp Met Leu Leu Phe Asp Glu Gln Glu Lys
                 465                 470                 475

 gga att gta act aaa ttt tat cag tta tca gct act ggt cag aag tta     1909
 Gly Ile Val Thr Lys Phe Tyr Gln Leu Ser Ala Thr Gly Gln Lys Leu
             480                 485                 490

 tat gta agg ctc ttt caa cgt aaa tta agc tgg att aag atg acc aaa     1957
 Tyr Val Arg Leu Phe Gln Arg Lys Leu Ser Trp Ile Lys Met Thr Lys
         495                 500                 505

 tta gag tat gaa gag att gcc tta gac tta aca cct gtg att gaa gaa     2005
 Leu Glu Tyr Glu Glu Ile Ala Leu Asp Leu Thr Pro Val Ile Glu Glu
     510                 515                 520

 ttg acg aat gca ggc ttt cta cag aca gaa tct gag ttg caa gaa ctc     2053
 Leu Thr Asn Ala Gly Phe Leu Gln Thr Glu Ser Glu Leu Gln Glu Leu
 525                 530                 535                 540

 tct gaa gtg ctt gaa ctc ctt tct gct cct gaa cta aaa tcc cta gcc     2101
 Ser Glu Val Leu Glu Leu Leu Ser Ala Pro Glu Leu Lys Ser Leu Ala
                 545                 550                 555

 aag acc ttc cac ttg gtg aat ccc aat gga cag aaa cag cag ctg gtg     2149
 Lys Thr Phe His Leu Val Asn Pro Asn Gly Gln Lys Gln Gln Leu Val
             560                 565                 570

 gac gcc ttt ctc aaa ttg gcc aaa cag cgt tca gtc tgc act tgg ggc     2197
 Asp Ala Phe Leu Lys Leu Ala Lys Gln Arg Ser Val Cys Thr Trp Gly
         575                 580                 585

 aag aat aag cct gga att ggt gca gtg att tta aaa aga gcc aaa gcc     2245
 Lys Asn Lys Pro Gly Ile Gly Ala Val Ile Leu Lys Arg Ala Lys Ala
     590                 595                 600

 ttg gct gga cag tca gta cga atc tgt aaa ggc ccc agg gct gtg ttt     2293
 Leu Ala Gly Gln Ser Val Arg Ile Cys Lys Gly Pro Arg Ala Val Phe
 605                 610                 615                 620

 tcc cgc atc ttg cta ctg ttt tcg ttg acc gac tca atg gaa gat gaa     2341
 Ser Arg Ile Leu Leu Leu Phe Ser Leu Thr Asp Ser Met Glu Asp Glu
                 625                 630                 635

 gac gcc gct tgt gga ggt cag gga cag ctt tca aca gtc ctg ttg gtc     2389
 Asp Ala Ala Cys Gly Gly Gln Gly Gln Leu Ser Thr Val Leu Leu Val
             640                 645                 650

 aac ctc ggc cga atg gag ttt cct agt tac acc atc aat cgg aaa acc     2437
 Asn Leu Gly Arg Met Glu Phe Pro Ser Tyr Thr Ile Asn Arg Lys Thr
         655                 660                 665

 cac atc ttc caa gac aga gat gat ctt atc aga tat gca gca gcc acg     2485
 His Ile Phe Gln Asp Arg Asp Asp Leu Ile Arg Tyr Ala Ala Ala Thr
     670                 675                 680

 cac atg ctg agt gac att tct tcc gca atg gcc aat ggg aac tgg gaa     2533
 His Met Leu Ser Asp Ile Ser Ser Ala Met Ala Asn Gly Asn Trp Glu
 685                 690                 695                 700

 gaa gct aag gag ctc gct cag tgt gca aaa agg gat tgg aac aga ctg     2581
 Glu Ala Lys Glu Leu Ala Gln Cys Ala Lys Arg Asp Trp Asn Arg Leu
                 705                 710                 715

 aaa aac cac cct tct ctg aga tgc cac gaa gat tta cca ctc ttc ctg     2629
 Lys Asn His Pro Ser Leu Arg Cys His Glu Asp Leu Pro Leu Phe Leu
             720                 725                 730

 cgg tgt ttc act gtt ggg tgg att tat aca agg att ttg tct cgg ttt     2677
 Arg Cys Phe Thr Val Gly Trp Ile Tyr Thr Arg Ile Leu Ser Arg Phe
         735                 740                 745

 gtg gaa ata ctg cag aga ctt cac atg tat gag gaa gcc gtc aga gaa     2725
 Val Glu Ile Leu Gln Arg Leu His Met Tyr Glu Glu Ala Val Arg Glu
     750                 755                 760

 ctt gaa agc ctt ttg tct cag aga att tat tgt cct gac agc aga ggc     2773
 Leu Glu Ser Leu Leu Ser Gln Arg Ile Tyr Cys Pro Asp Ser Arg Gly
 765                 770                 775                 780

 cga tgg tgg gat cga ctg gcc ctt aat tta cac cag cac ttg aag cgc     2821
 Arg Trp Trp Asp Arg Leu Ala Leu Asn Leu His Gln His Leu Lys Arg
                 785                 790                 795

 ctg gaa ccg act atc aag tgc atc aca gag ggg ctg gcg gat ccg gaa     2869
 Leu Glu Pro Thr Ile Lys Cys Ile Thr Glu Gly Leu Ala Asp Pro Glu
             800                 805                 810

 gtc aga acg gga cac cgc ctt tca ctg tat cag cga gcc gtg cgc ctg     2917
 Val Arg Thr Gly His Arg Leu Ser Leu Tyr Gln Arg Ala Val Arg Leu
         815                 820                 825

 cga gag tct ccg agc tgt aaa aag ttc aag cac ctc ttc cag cag ctc     2965
 Arg Glu Ser Pro Ser Cys Lys Lys Phe Lys His Leu Phe Gln Gln Leu
     830                 835                 840

 cca gaa atg gct gtg caa gat gtg aaa cac gtg acc atc aca ggc agg     3013
 Pro Glu Met Ala Val Gln Asp Val Lys His Val Thr Ile Thr Gly Arg
 845                 850                 855                 860

 ctg tgc cca cag cgt ggg atg tgc aag tct gtg ttt gtg atg gag gcc     3061
 Leu Cys Pro Gln Arg Gly Met Cys Lys Ser Val Phe Val Met Glu Ala
                 865                 870                 875

 ggg gag gcc gct gac ccc acc acg gtc ctg tgc tct gtg gag gag ctg     3109
 Gly Glu Ala Ala Asp Pro Thr Thr Val Leu Cys Ser Val Glu Glu Leu
             880                 885                 890

 gca ctg gcc cat tac aga cgc agc ggt ttt gac cag ggg att cat ggc     3157
 Ala Leu Ala His Tyr Arg Arg Ser Gly Phe Asp Gln Gly Ile His Gly
         895                 900                 905

 gaa ggg tcc acc ttc agc acc ctg tat ggc ctc ctc ctg tgg gac atc     3205
 Glu Gly Ser Thr Phe Ser Thr Leu Tyr Gly Leu Leu Leu Trp Asp Ile
     910                 915                 920

 atc ttc atg gat ggg att ccg gat gtc ttc aga aac gcc tgt cag gca     3253
 Ile Phe Met Asp Gly Ile Pro Asp Val Phe Arg Asn Ala Cys Gln Ala
 925                 930                 935                 940

 ttc ccc ctg gac ttg tgc aca gac agc ttc ttc aca agc aga cgc cca     3301
 Phe Pro Leu Asp Leu Cys Thr Asp Ser Phe Phe Thr Ser Arg Arg Pro
                 945                 950                 955

 gcc ctt gag gcc agg ctg cag ctg att cat gat gcc ccc gag gag agc     3349
 Ala Leu Glu Ala Arg Leu Gln Leu Ile His Asp Ala Pro Glu Glu Ser
             960                 965                 970

 ctg cgg gcc tgg gtg gca gcc acg tgg cat gag cag gaa ggc aga gtg     3397
 Leu Arg Ala Trp Val Ala Ala Thr Trp His Glu Gln Glu Gly Arg Val
         975                 980                 985

 gct tcc ctt gtc agc tgg gat cgc ttc acg tct ctt cag caa gct cag     3445
 Ala Ser Leu Val Ser Trp Asp Arg Phe Thr Ser Leu Gln Gln Ala Gln
     990                 995                1000

 gat ctt gtc tcc tgc ctg ggg ggc cct gtg ctc agt ggt gtg tgc agg     3493
 Asp Leu Val Ser Cys Leu Gly Gly Pro Val Leu Ser Gly Val Cys Arg
1005                1010                1015                1020

 cac ctg gct gct gac ttt cga cac tgt cga ggg ggc ctc ccc gac ctg     3541
 His Leu Ala Ala Asp Phe Arg His Cys Arg Gly Gly Leu Pro Asp Leu
                1025                1030                1035

 gtg gtg tgg aac tcc cag agc cgt cac ttt aag ctg gtg gaa gtt aaa     3589
 Val Val Trp Asn Ser Gln Ser Arg His Phe Lys Leu Val Glu Val Lys
            1040                1045                1050

 ggc ccc aat gat cgt ctt tca cat aag cag atg atc tgg ctg gct gaa     3637
 Gly Pro Asn Asp Arg Leu Ser His Lys Gln Met Ile Trp Leu Ala Glu
        1055                1060                1065

 ctg cag aag ctg ggg gct gaa gta gaa gtc tgc cat gtg gtt gca gtt     3685
 Leu Gln Lys Leu Gly Ala Glu Val Glu Val Cys His Val Val Ala Val
    1070                1075                1080

 gga gct aag agc caa agc ctt agc taa aagat tccctacagg agaaaatgga     3737
 Gly Ala Lys Ser Gln Ser Leu Ser 
1085                1090

 aatgaggagg agagaaactc cggtgtcccc gaggtgtcgg tgtggtgagg gccgctggcg   3797

 ttgaagtaca tcctgctctg gcccagctcc ccatagcagg cctccagggg gccactgcgc   3857

 tgttgccgca gcatcctgct cagtacgtcg acttcatcag ccaggaggga gagcttgtga   3917

 aaggctgtga tggagccacc caggctgatc tgggcctcgg gaacccagcg gaagtagcac   3977

 agtttccaca gttttatgtg tgttccagag acacgtggca gaataacacc gtgcaggttg   4037

 gcgggtttgg aaaaccattc tctaaaatac tgctccgtat cactgttctg gctgtcggtt   4097

 tgctgagctg gatctggctt tggttttaat atcaatgaat ttctccttgg aagtaattct   4157

 tggtcactga tgattccatt ctttaaggca gacggcattc ctcttagtgt ggagctgtag   4217

 cttttctata cagaagagat tttattatgt tccggggatt ccctttttag aaagattgaa   4277

 ggatgcaatg gcaaatataa actcaatact atgaaaaatt aatggaattt cagcctcaaa   4337

 gaacattttc ctcccttcct ttgtgtcctt attctaatcc tcctcccctg gaattacact   4397

 tttttatgtg ttgactctac ctaggctgtt actatcagcc tgaatggggg cgggatgaga   4457

 gtacctccta tccactaatt tgcttaagga taagttctaa gacgggctag aaaaaacact   4517

 agacctggtc gattctatca agaacaatgg caaactgaac agaggcagtc aggaggccaa   4577

 atgtctgatt ctttgttctg tacctttcag tagtctgcaa attttctacc aaaaaaaaat   4637

 cccaagaatt tatttgggaa ttattaaaaa ggcaaacaat gaatgttatt aggacaagaa   4697

 tatagcagtc aggaggccat gactacatca cagccaggcg gcattccctg ccacagtggc   4757

 ggcttgaatc atcaagaaat ggataaatgg ggctttagta aatcaggctt gcaggctcaa   4817

 agctgcaatc tgcccactct caggtactga gactttgtgg gcctcagaca ccaggaagaa   4877

 agttgggata cagtcatttg agttaaaaag ggaatgaccc ctcagaaacc cacattagca   4937

 gtgttactct tggaactgcc tttactttta acgctctctg ttctgaaaaa gaggtgtttg   4997

 gttacgtgtg agccaacatc acgttttgtt agctgtgatt tacctttgtc cgtttaaaag   5057

 acttcacgga gccattctgt atacaaggtg tgctctttcc aatgtagaag gggttatgga   5117

 aaagggtgcg atcctttgct gtaaactgga gagaccagtc ccaaacagag gggaatttta   5177

 agcccttctc atcacccaat tggatgtttt tgcttatagc aaattcctgc aaaataaata   5237

 aataaatatt tgcaaaact                                                5256




      <210> 287
      <211> 990
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (40)..(990)

      <400> 287
 agaattcccg gaagtggccg gctgggatca gcctttaag   atg gcg tct cct cag      54
                                              Met Ala Ser Pro Gln
                                                1               5

 ggg ggc cag att gcg atc gcg atg agg ctt cgg aac cag ctc cag tca      102
 Gly Gly Gln Ile Ala Ile Ala Met Arg Leu Arg Asn Gln Leu Gln Ser
                  10                  15                  20

 gtg tac aag atg gac ccg cta cgg aac gag gag gag gtt cga gtg aag      150
 Val Tyr Lys Met Asp Pro Leu Arg Asn Glu Glu Glu Val Arg Val Lys
              25                  30                  35

 atc aaa gac ttg aat gaa cac att gtt tgc tgc cta tgc gcc ggc tac      198
 Ile Lys Asp Leu Asn Glu His Ile Val Cys Cys Leu Cys Ala Gly Tyr
          40                  45                  50

 ttc gtg gat gcc acc acc atc aca gag tgt ctt cat act ttc tgc aag      246
 Phe Val Asp Ala Thr Thr Ile Thr Glu Cys Leu His Thr Phe Cys Lys
      55                  60                  65

 agt tgt att gtg aag tac ctc caa act agc aag tac tgc ccc atg tgc      294
 Ser Cys Ile Val Lys Tyr Leu Gln Thr Ser Lys Tyr Cys Pro Met Cys
  70                  75                  80                  85

 aac att aag atc cac gag aca cag cca ctg ctc aac ctc aaa ctg gac      342
 Asn Ile Lys Ile His Glu Thr Gln Pro Leu Leu Asn Leu Lys Leu Asp
                  90                  95                 100

 cgg gtc atg cag gac atc gtg tat aag ctg gtg cct ggc ttg caa gac      390
 Arg Val Met Gln Asp Ile Val Tyr Lys Leu Val Pro Gly Leu Gln Asp
             105                 110                 115

 agt gaa gag aaa cgg att cgg gaa ttc tac cag tcc cga ggt ttg gac      438
 Ser Glu Glu Lys Arg Ile Arg Glu Phe Tyr Gln Ser Arg Gly Leu Asp
         120                 125                 130

 cgg gtc acc cag ccc act ggg gaa gag cca gca ctg agc aac ctc ggc      486
 Arg Val Thr Gln Pro Thr Gly Glu Glu Pro Ala Leu Ser Asn Leu Gly
     135                 140                 145

 ctc ccc ttc agc agc ttt gac cac tct aaa gcc cac tac tat cgc tat      534
 Leu Pro Phe Ser Ser Phe Asp His Ser Lys Ala His Tyr Tyr Arg Tyr
 150                 155                 160                 165

 gat gag cag ttg aac ctg tgc ctg gag cgg ctg agt tct ggc aaa gac      582
 Asp Glu Gln Leu Asn Leu Cys Leu Glu Arg Leu Ser Ser Gly Lys Asp
                 170                 175                 180

 aag aat aaa agc gtc ctg cag aac aag tat gtc cga tgt tct gtt aga      630
 Lys Asn Lys Ser Val Leu Gln Asn Lys Tyr Val Arg Cys Ser Val Arg
             185                 190                 195

 gct gag gta cgc cat ctc cgg agg gtc ctg tgt cac cgc ttg atg cta      678
 Ala Glu Val Arg His Leu Arg Arg Val Leu Cys His Arg Leu Met Leu
         200                 205                 210

 aac cct cag cat gtg cag ctc ctt ttt gac aat gaa gtt ctc cct gat      726
 Asn Pro Gln His Val Gln Leu Leu Phe Asp Asn Glu Val Leu Pro Asp
     215                 220                 225

 cac atg aca atg aag cag ata tgg ctc tcc cgc tgg ttc ggc aag gac      774
 His Met Thr Met Lys Gln Ile Trp Leu Ser Arg Trp Phe Gly Lys Asp
 230                 235                 240                 245

 tca cat cca aag gcg aca gca cca gga ttt gct ccc gcc ttt ggc aca      822
 Ser His Pro Lys Ala Thr Ala Pro Gly Phe Ala Pro Ala Phe Gly Thr
                 250                 255                 260

 gag gag gac ggg tcc ctc tct cag cct ggc cag tct ttc cca ggg ctt      870
 Glu Glu Asp Gly Ser Leu Ser Gln Pro Gly Gln Ser Phe Pro Gly Leu
             265                 270                 275

 gat ggg aaa aag gac ttc cct aga agg ggt tat tcc gag ggt cct cca      918
 Asp Gly Lys Lys Asp Phe Pro Arg Arg Gly Tyr Ser Glu Gly Pro Pro
         280                 285                 290

 acc ctg cta cac att cac aga att cag tgg aat gtc cgg gcc ggc aat      966
 Thr Leu Leu His Ile His Arg Ile Gln Trp Asn Val Arg Ala Gly Asn
     295                 300                 305

 ccg aga cta aag gtc gtt tat tga                                      990
 Pro Arg Leu Lys Val Val Tyr 
 310                 315





      <210> 288
      <211> 1835
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(413)

      <220>
      <221> misc_feature
      <222> (1)...(1835)
      <223> n = a,t,c or g

      <400> 288
 tgccgaattc ggcacgaggc ggagggagtc gagccagcgt cgccgcg  atg gtg ttg      56
                                                      Met Val Leu
                                                        1

 ttg gag agc gag cag ttc ctg acg gag ctg acc aga ctt ttc cag aag      104
 Leu Glu Ser Glu Gln Phe Leu Thr Glu Leu Thr Arg Leu Phe Gln Lys
       5                  10                  15

 tgc cgg acg tcg ggc agc gtc tat atc acc ttg aag aag tat gac ggt      152
 Cys Arg Thr Ser Gly Ser Val Tyr Ile Thr Leu Lys Lys Tyr Asp Gly
  20                  25                  30                  35

 cga acc aaa ccc att cca aag aag ggt act gtg gag ggc ttt gag ccc      200
 Arg Thr Lys Pro Ile Pro Lys Lys Gly Thr Val Glu Gly Phe Glu Pro
                  40                  45                  50

 gca gac aac aag tgt ctg tta aga gct acc gat ggg aag aag aag atc      248
 Ala Asp Asn Lys Cys Leu Leu Arg Ala Thr Asp Gly Lys Lys Lys Ile
              55                  60                  65

 agc act gtg gtg agc tcc aag gaa gtg aat aag ttt cag atg gct tat      296
 Ser Thr Val Val Ser Ser Lys Glu Val Asn Lys Phe Gln Met Ala Tyr
          70                  75                  80

 tca aac ctc ctt aga gct aac atg gat ggg ctg aag aag aga gac aaa      344
 Ser Asn Leu Leu Arg Ala Asn Met Asp Gly Leu Lys Lys Arg Asp Lys
      85                  90                  95

 aag aag cag caa caa cag cag caa cag cag cac agt aaa ggg cat aca      392
 Lys Lys Gln Gln Gln Gln Gln Gln Gln Gln His Ser Lys Gly His Thr
 100                 105                 110                 115

 ttt cct gct ttc acc aat taa cc actgaattgc tattttttcc ttttggccag      445
 Phe Pro Ala Phe Thr Asn 
                 120

 atagctaggt ttctggttcc cccacagtag gtgttttcac ataagattag ggtccttttg    505

 gaaagaatag ttgcagtgtt tataggatag ttgtggtaag aatctagttt attttgcatt    565

 tggctaattg gtctgtgctg catggttata tactcctgga ttatagatta aaagtctctg    625

 tagacatctc tgtgaagagc aagctatcat taaacatgtc tgtttatcag cactgtctct    685

 ttattccttt cccaacccat tttaatagtt ctggcaataa ctactaaatc tagaatgatg    745

 tgattaatga ataggcttta gctctataat atcttctagg ttattagaat tgaaacctga    805

 cagttttata aaaagtcatg ttatctcatg agctgcttcc cacctggctg tataatttta    865

 tcatcatggt tccccagttt cgatgagttc tcacagtcaa atgagagttt gtttaaccac    925

 cttaggagaa acatactaca aagtcatcaa gaataaaggt tccaaagcta aaaaacaaaa    985

 tacacacacc aacaacaaac aacaaacaaa ctaccaacaa aacaaaaaac aatataacaa   1045

 aaaaaaaaaa aaaacacaaa acaaaaaaat ggctgggccg cgcccccccc ccaaaaaaac   1105

 ttttacaaca ccaccctttg ggggcggcgc gcccccctat atgtaggaca gaccagaggc   1165

 ccaaccacag gtatcatctc cacgaaaaca cacggtccca caaacaggac ggttggagtg   1225

 atgcaccacg caaaaaaata aaaaaagcgc gcggcgggtc cngggggccg cccgtgtctt   1285

 gtgcgcgaaa aaacacaccg caccgcacga gacgagagag cagaacacaa actacaagcg   1345

 atagcacaca agagaggacg acactacata cgacagacac agcaggccag aagacaacca   1405

 ccagcagaac ggcaagcgaa acataccaac atccattaga gagatctata acaatacaaa   1465

 tagaggtaga ttcgaatcga caactcacta cagatctgac agtaaatata tgacacatct   1525

 cagtgagaac gatctgatga ttcgatcgac tgagataaca agaatacata tcacctaatg   1585

 taacgacgac aaaacagatg cgaacaggga aagagacaca tccagagaag atcaaggaga   1645

 aagaatcata atacctcaca aatctcatca tatcggcatc aaggcagaca atgctctctc   1705

 caacctctct ccggagaaaa acatctctac cagaaatcga taagttacaa tctaagttag   1765

 agttatgaat agaaaagagt gacaacggac acagtacaat caacaagcta taaaaagaga   1825

 atagatgaaa                                                          1835




      <210> 289
      <211> 681
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(681)

      <400> 289
  atg tcc atg tgg ggg ata tcc acg gcc tta gcc tcg tca aga ccc aga      48
  Met Ser Met Trp Gly Ile Ser Thr Ala Leu Ala Ser Ser Arg Pro Arg
    1               5                  10                  15

 gca gag tca gcc agc atg acc gag cgc cgc gtc ccc ttc tcg ctc ctg       96
 Ala Glu Ser Ala Ser Met Thr Glu Arg Arg Val Pro Phe Ser Leu Leu
              20                  25                  30

 cgg ggc ccc agc tgg gac ccc ttc cgc gac tgg tac ccg cat agc cgc      144
 Arg Gly Pro Ser Trp Asp Pro Phe Arg Asp Trp Tyr Pro His Ser Arg
          35                  40                  45

 ctc ttc gac cag gcc ttc ggg ctg ccc cgg ctg ccg gag gag tgg tcg      192
 Leu Phe Asp Gln Ala Phe Gly Leu Pro Arg Leu Pro Glu Glu Trp Ser
      50                  55                  60

 cag tgg tta ggc ggc agc agc tgg cca ggc tac gtg cgc ccc ctg ccc      240
 Gln Trp Leu Gly Gly Ser Ser Trp Pro Gly Tyr Val Arg Pro Leu Pro
  65                  70                  75                  80

 ccc gcc gcc atc gag agc ccc gca gtg gcc gcg ccc gcc tac agc cgc      288
 Pro Ala Ala Ile Glu Ser Pro Ala Val Ala Ala Pro Ala Tyr Ser Arg
                  85                  90                  95

 gcg ctc agc cgg caa ctc agc agc ggg gtc tcg gag atc cgg cac act      336
 Ala Leu Ser Arg Gln Leu Ser Ser Gly Val Ser Glu Ile Arg His Thr
             100                 105                 110

 gcg gac cgc tgg cgc gtg tcc ctg gat gtc aac cac ttc gcc ccg gac      384
 Ala Asp Arg Trp Arg Val Ser Leu Asp Val Asn His Phe Ala Pro Asp
         115                 120                 125

 gag ctg acg gtc aag acc aag gat ggc gtg gtg gag atc acc ggc aag      432
 Glu Leu Thr Val Lys Thr Lys Asp Gly Val Val Glu Ile Thr Gly Lys
     130                 135                 140

 cac gag gag cgg cag gac gag cat ggc tac atc tcc cgg tgc ttc acg      480
 His Glu Glu Arg Gln Asp Glu His Gly Tyr Ile Ser Arg Cys Phe Thr
 145                 150                 155                 160

 cgg aaa tac acg ctg ccc ccc ggt gtg gac ccc acc caa gtt tcc tcc      528
 Arg Lys Tyr Thr Leu Pro Pro Gly Val Asp Pro Thr Gln Val Ser Ser
                 165                 170                 175

 tcc ctg tcc cct gag ggc aca ctg acc gtg gag gcc ccc atg ccc aag      576
 Ser Leu Ser Pro Glu Gly Thr Leu Thr Val Glu Ala Pro Met Pro Lys
             180                 185                 190

 cta gcc acg cag tcc aac gag atc acc atc cca gtc acc ttc gag tcg      624
 Leu Ala Thr Gln Ser Asn Glu Ile Thr Ile Pro Val Thr Phe Glu Ser
         195                 200                 205

 cgg gcc cag ctt ggg ggc cca gaa gct gca aaa tcc gat gag act gcc      672
 Arg Ala Gln Leu Gly Gly Pro Glu Ala Ala Lys Ser Asp Glu Thr Ala
     210                 215                 220

 gcc aag taa                                                          681
 Ala Lys 
 225





      <210> 290
      <211> 929
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (79)..(462)

      <220>
      <221> misc_feature
      <222> (1)...(929)
      <223> n = a,t,c or g

      <400> 290
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnccc gccggctcaa     60

 ctgtaccact ggctggag  atg cgg acc aaa atg cgc atc atg ggt ttc aat     111
                      Met Arg Thr Lys Met Arg Ile Met Gly Phe Asn
                        1               5                  10

 gcc gct gcc atc aag ccg ctg aac gag ggt gca gcc gcc gag ctg ggc      159
 Ala Ala Ala Ile Lys Pro Leu Asn Glu Gly Ala Ala Ala Glu Leu Gly
              15                  20                  25

 gcg gag ctg ctg ggc gag ggc atc atc ttc atc acc gcc tgc agc tgc      207
 Ala Glu Leu Leu Gly Glu Gly Ile Ile Phe Ile Thr Ala Cys Ser Cys
          30                  35                  40

 ctg atg ctg gag tat tgg cgc cac cag ttg cag cag cgc cgc aag gaa      255
 Leu Met Leu Glu Tyr Trp Arg His Gln Leu Gln Gln Arg Arg Lys Glu
      45                  50                  55

 aag gag cga cgt gtt gcc agg gag gcg ctg cgg ggc gag gtg ggc cac      303
 Lys Glu Arg Arg Val Ala Arg Glu Ala Leu Arg Gly Glu Val Gly His
  60                  65                  70                  75

 ttg ggg ctg gcg ctc gag gag ttg cag gcg cag gtg cag gcg acg tcg      351
 Leu Gly Leu Ala Leu Glu Glu Leu Gln Ala Gln Val Gln Ala Thr Ser
                  80                  85                  90

 acg cag ctc gcc ctg gag gag ctg cgc gct cag ctg cag gag gtg cga      399
 Thr Gln Leu Ala Leu Glu Glu Leu Arg Ala Gln Leu Gln Glu Val Arg
              95                 100                 105

 gcc cac ctc tgc ctc cga gac ccg ccg cct gca ccc cca gtt gcg ccg      447
 Ala His Leu Cys Leu Arg Asp Pro Pro Pro Ala Pro Pro Val Ala Pro
         110                 115                 120

 gcg tcc gag aaa tag gaggtctcgg ggccctggtc ttggaggtga ctgctgtctg      502
 Ala Ser Glu Lys 
     125

 gactgcgaag tctctgtctt ggcctattct ccgcactgtc ccatcctgga ccggcccagc    562

 tgacaccacc cagtccttcg ggggcgccgg agagatcctg ggctggagct gatcgaacct    622

 ccctactaac ctgcccagtg gtaccttcca ctgggactct ccgcctcctg caggtggaac    682

 gttccaagaa ggaccccgcc ctatcccacc ccgcccctgc cagcgcattt gttgagcact    742

 ttggaaagac agcgtctttt atcagacccc acctccctac cgctaggtag gccagcagga    802

 cgtccacctc ttttggcaaa acaaaattct gcacccggat ttagccacct ctcattctgt    862

 cacccgcacc ctcactcacc tgagtggacc cttcccctag gacgctcatc ctttgcaccg    922

 aacacca                                                              929




      <210> 291
      <211> 807
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(807)

      <400> 291
  atg gag ctc ccc aac tac agc cgg cag ctg ctg cag cag ctg tac act      48
  Met Glu Leu Pro Asn Tyr Ser Arg Gln Leu Leu Gln Gln Leu Tyr Thr
    1               5                  10                  15

 ctg tgc aag gag cag cag ttc tgt gat tgc acc atc tcc att ggt acc       96
 Leu Cys Lys Glu Gln Gln Phe Cys Asp Cys Thr Ile Ser Ile Gly Thr
              20                  25                  30

 att tac ttc agg gct cac aag ctt gtc ctg gct gct gcc agc ctc ctg      144
 Ile Tyr Phe Arg Ala His Lys Leu Val Leu Ala Ala Ala Ser Leu Leu
          35                  40                  45

 ttc aaa acc ctg ctg gat aac aca gat acc atc tcc atc gat gca tct      192
 Phe Lys Thr Leu Leu Asp Asn Thr Asp Thr Ile Ser Ile Asp Ala Ser
      50                  55                  60

 gtg gtg agc ccc gag gag ttt gcg ctc ttg ttg gaa atg atg tac acg      240
 Val Val Ser Pro Glu Glu Phe Ala Leu Leu Leu Glu Met Met Tyr Thr
  65                  70                  75                  80

 ggc aaa cta cct gtg ggc aag cac aac ttc tcc aaa atc atc tcc tta      288
 Gly Lys Leu Pro Val Gly Lys His Asn Phe Ser Lys Ile Ile Ser Leu
                  85                  90                  95

 gca gac agt cta cag atg ttt gat gta gct gtt agc tgc aaa aat ctt      336
 Ala Asp Ser Leu Gln Met Phe Asp Val Ala Val Ser Cys Lys Asn Leu
             100                 105                 110

 ctg acc agc ctt gta aac tgc tcg gtt cag ggt cag gtg gta agg gat      384
 Leu Thr Ser Leu Val Asn Cys Ser Val Gln Gly Gln Val Val Arg Asp
         115                 120                 125

 gtc tct gcg cca tcc tca gag aca ttc aga aag gaa cca gag aag cct      432
 Val Ser Ala Pro Ser Ser Glu Thr Phe Arg Lys Glu Pro Glu Lys Pro
     130                 135                 140

 caa gta gaa atc ctt tca tct gaa ggt gct gga gag cct cat tct tcc      480
 Gln Val Glu Ile Leu Ser Ser Glu Gly Ala Gly Glu Pro His Ser Ser
 145                 150                 155                 160

 cca gag ctt gct gcc act cca ggg ggc cct gtg aaa gct gag act gag      528
 Pro Glu Leu Ala Ala Thr Pro Gly Gly Pro Val Lys Ala Glu Thr Glu
                 165                 170                 175

 gaa gca gcc cat tca gtt tca caa gag atg agt gtg aat tct ccc aca      576
 Glu Ala Ala His Ser Val Ser Gln Glu Met Ser Val Asn Ser Pro Thr
             180                 185                 190

 gcc cag gag agc cag agg aat gca gaa acc cca gcg gag act cct act      624
 Ala Gln Glu Ser Gln Arg Asn Ala Glu Thr Pro Ala Glu Thr Pro Thr
         195                 200                 205

 aca gct gaa gct tgt tcc ccc tcc cct gct gtg caa acc ttt agt gag      672
 Thr Ala Glu Ala Cys Ser Pro Ser Pro Ala Val Gln Thr Phe Ser Glu
     210                 215                 220

 gca aag aag aca agc aca gaa cca gga tgt gaa agg aaa cac tac cag      720
 Ala Lys Lys Thr Ser Thr Glu Pro Gly Cys Glu Arg Lys His Tyr Gln
 225                 230                 235                 240

 ctg aat ttt ctt cta gaa aat gaa ggt gtc ttc tca gat gca ctc atg      768
 Leu Asn Phe Leu Leu Glu Asn Glu Gly Val Phe Ser Asp Ala Leu Met
                 245                 250                 255

 gtt acc cag gat gtt tta aaa aaa aaa aaa aaa aaa tga                  807
 Val Thr Gln Asp Val Leu Lys Lys Lys Lys Lys Lys 
             260                 265





      <210> 292
      <211> 992
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (312)..(992)

      <400> 292
 tatctggtct ttttctgctt tcatgattgg ttcggacatc cagccttttt tataagatac     60

 atacagtggc agattttcta aacatagaaa gggagttcac atgctacatg gtcaaaaata    120

 aaactgatac atgtccattt cagtattcaa taaatatttg tcagatgagt gaatgagaga    180

 atcagagtca tgatttcctg tctctagacc tttaagtcac caaacattga agtgataatg    240

 gtgttgctaa tgtaattgaa aataaaatcg aaggagcaag ctatggaggg gaacagggat    300

 gaagctgaga a atg tgt cga cat cgt cca gga ggc tct gag tgc tgg caa     350
              Met Cys Arg His Arg Pro Gly Gly Ser Glu Cys Trp Gln
                1               5                  10

 ccg cga gaa ggc cca gcg ttt cct gca gaa ggc cga gaa gct cta ccc      398
 Pro Arg Glu Gly Pro Ala Phe Pro Ala Glu Gly Arg Glu Ala Leu Pro
      15                  20                  25

 act gcc ctt ggc ctg cgc ata aac aaa tat aaa aat tac tat gaa gta      446
 Thr Ala Leu Gly Leu Arg Ile Asn Lys Tyr Lys Asn Tyr Tyr Glu Val
  30                  35                  40                  45

 ctt gga gtt acg aaa gat agt ggt gat gaa gat ttg aaa aaa gct tat      494
 Leu Gly Val Thr Lys Asp Ser Gly Asp Glu Asp Leu Lys Lys Ala Tyr
                  50                  55                  60

 aga aag ctt gct ttg aag ttt cat cca gac aaa aac cat gca cct gga      542
 Arg Lys Leu Ala Leu Lys Phe His Pro Asp Lys Asn His Ala Pro Gly
              65                  70                  75

 gca aca gat gct ttt aaa aag gtt ggg aat gct tat gct gtt tta agt      590
 Ala Thr Asp Ala Phe Lys Lys Val Gly Asn Ala Tyr Ala Val Leu Ser
          80                  85                  90

 aat cca gaa aag cga aaa cag tat gac ctc acg ggc aat gaa gaa caa      638
 Asn Pro Glu Lys Arg Lys Gln Tyr Asp Leu Thr Gly Asn Glu Glu Gln
      95                 100                 105

 gca tgt aac cac caa aac aat ggc aga ttt aat ttc cat aga ggt ttt      686
 Ala Cys Asn His Gln Asn Asn Gly Arg Phe Asn Phe His Arg Gly Phe
 110                 115                 120                 125

 gtg aaa tct gga aca ggg caa act att aaa acg cag aca gaa aac ttg      734
 Val Lys Ser Gly Thr Gly Gln Thr Ile Lys Thr Gln Thr Glu Asn Leu
                 130                 135                 140

 ggt ggt gtt tat tat gtc agc aag gac ttt aaa aat gaa tat aaa gga      782
 Gly Gly Val Tyr Tyr Val Ser Lys Asp Phe Lys Asn Glu Tyr Lys Gly
             145                 150                 155

 atg tta tta caa aag gca gaa aag agt gtg gag gaa gat tat gtg act      830
 Met Leu Leu Gln Lys Ala Glu Lys Ser Val Glu Glu Asp Tyr Val Thr
         160                 165                 170

 aat att cga aat aac tgc tgg aaa gaa aga caa caa aaa aca gat atg      878
 Asn Ile Arg Asn Asn Cys Trp Lys Glu Arg Gln Gln Lys Thr Asp Met
     175                 180                 185

 cag tat gca gca aaa gta tac cgt ggt gat cga ctc cga agg aag tca      926
 Gln Tyr Ala Ala Lys Val Tyr Arg Gly Asp Arg Leu Arg Arg Lys Ser
 190                 195                 200                 205

 gat gcc ttg agc atg gac aac tgt aaa gaa tta gag cgg ctt acc ggt      974
 Asp Ala Leu Ser Met Asp Asn Cys Lys Glu Leu Glu Arg Leu Thr Gly
                 210                 215                 220

 ctt tat aaa gga gga tga                                              992
 Leu Tyr Lys Gly Gly 
             225





      <210> 293
      <211> 1099
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (215)..(1099)

      <400> 293
 aaggaaagct ggtgatgggg ataagaggtg tgatggtgag gtgctttgag aaaacagaat     60

 acaatgagag gacaggaaag agtaaggatt cagcgaggga aagtggcctc catgggatcc    120

 tcagacaaga ggcagggaag cagactgcca gcttccaccg ccactacgct gcacagctgg    180

 ggaatcctga ggaagctgtt tccacaaact gcct    atg gca agg atc ttg tcc     232
                                          Met Ala Arg Ile Leu Ser
                                            1               5

 agg ggg ctg cag aag aca gga gga aca agc aaa aac caa agg agc tgg      280
 Arg Gly Leu Gln Lys Thr Gly Gly Thr Ser Lys Asn Gln Arg Ser Trp
              10                  15                  20

 atg tgg agg aat gtg agg agc aca gaa gag cag caa ctt gta gaa aga      328
 Met Trp Arg Asn Val Arg Ser Thr Glu Glu Gln Gln Leu Val Glu Arg
          25                  30                  35

 gac aca gtt caa atc cca ttt cat gtt gga act ggg cat ttc cca gac      376
 Asp Thr Val Gln Ile Pro Phe His Val Gly Thr Gly His Phe Pro Asp
      40                  45                  50

 ttt ttg aga ctt ggt atc ttc aca gta aag ggt atg tta cta tat cca      424
 Phe Leu Arg Leu Gly Ile Phe Thr Val Lys Gly Met Leu Leu Tyr Pro
  55                  60                  65                  70

 aag acc tca aaa ata gtt caa agg aga tgg aag ttt gtt cct gtc act      472
 Lys Thr Ser Lys Ile Val Gln Arg Arg Trp Lys Phe Val Pro Val Thr
                  75                  80                  85

 aac aat gct gag gtc cag gtt ggt gaa tgc ttt ttc tac atg cag tca      520
 Asn Asn Ala Glu Val Gln Val Gly Glu Cys Phe Phe Tyr Met Gln Ser
              90                  95                 100

 ctg atg aac cca ggt tcc ttc cat cct gtt gct gtc acc aag ggc att      568
 Leu Met Asn Pro Gly Ser Phe His Pro Val Ala Val Thr Lys Gly Ile
         105                 110                 115

 gtc ttt gtc tgc ata gtt agt gct agg cca cag gca cat tca tat tca      616
 Val Phe Val Cys Ile Val Ser Ala Arg Pro Gln Ala His Ser Tyr Ser
     120                 125                 130

 gct caa ggg aag aag gaa gag agc tgc tcc ggg aca agg agc ttc ttt      664
 Ala Gln Gly Lys Lys Glu Glu Ser Cys Ser Gly Thr Arg Ser Phe Phe
 135                 140                 145                 150

 aca ttg aag atg act cag aag ttg cat tta gca ctt cca tgc gtc cct      712
 Thr Leu Lys Met Thr Gln Lys Leu His Leu Ala Leu Pro Cys Val Pro
                 155                 160                 165

 cac tgg cct gaa ctt agt cac atg gcc aca ctt agc cgc aag gga gac      760
 His Trp Pro Glu Leu Ser His Met Ala Thr Leu Ser Arg Lys Gly Asp
             170                 175                 180

 tgc tgg tcc tcc aag atg gta tca gtt ata cca gtg aag gag aag aaa      808
 Cys Trp Ser Ser Lys Met Val Ser Val Ile Pro Val Lys Glu Lys Lys
         185                 190                 195

 ctc ctg gat gtc aaa cta ggg gag ctg cca agc tgg ata ctg atg caa      856
 Leu Leu Asp Val Lys Leu Gly Glu Leu Pro Ser Trp Ile Leu Met Gln
     200                 205                 210

 gat ttc acc cct agt ggc att gct gga gca ttt caa aga ggt ttc tac      904
 Asp Phe Thr Pro Ser Gly Ile Ala Gly Ala Phe Gln Arg Gly Phe Tyr
 215                 220                 225                 230

 tgg tac tac aac aag tac atc gac gtg aag aaa ggg tgt ctc agg ggg      952
 Trp Tyr Tyr Asn Lys Tyr Ile Asp Val Lys Lys Gly Cys Leu Arg Gly
                 235                 240                 245

 ttc cac ggt act ggc agc tta cat gct ctt cag cta ctg cct ttc cta     1000
 Phe His Gly Thr Gly Ser Leu His Ala Leu Gln Leu Leu Pro Phe Leu
             250                 255                 260

 caa gga gct caa gca cca gca gct act caa gta tca ctg aag aag aag     1048
 Gln Gly Ala Gln Ala Pro Ala Ala Thr Gln Val Ser Leu Lys Lys Lys
         265                 270                 275

 gca cac tcc gca ctc ccc cac acg acc ttc ttg gcc cga gcc cct cca     1096
 Ala His Ser Ala Leu Pro His Thr Thr Phe Leu Ala Arg Ala Pro Pro
     280                 285                 290

 taa                                                                 1099
 






      <210> 294
      <211> 1640
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (170)..(1420)

      <400> 294
 agcggagaga ccagccagcg ggtggcggcg gcccccagca cggccggtgc aaggcctcgg     60

 gttaagctgg cggccgagcg gggctcggcc cggggtgctc ggggagctcg ccgctggcgg    120

 gcagcaggag gaacgcggct ggcggctgcg tcccgatgcg gtgcgcgcc    atg gcg     175
                                                          Met Ala
                                                            1

 ggc ggg ccc ccc aag gcc ctg ccg tcc acg ggg ccc cac tcc ctg cgc      223
 Gly Gly Pro Pro Lys Ala Leu Pro Ser Thr Gly Pro His Ser Leu Arg
           5                  10                  15

 gac atg ccg cac ccg ctg gcc ggc tcc agc agc gag gag gcc gtg ggt      271
 Asp Met Pro His Pro Leu Ala Gly Ser Ser Ser Glu Glu Ala Val Gly
      20                  25                  30

 ggt gac agc acg ccc agc ccg gac ctg ctg atg gcc cgc agc ttc ggt      319
 Gly Asp Ser Thr Pro Ser Pro Asp Leu Leu Met Ala Arg Ser Phe Gly
  35                  40                  45                  50

 gac aag gat ctc att ttg ccc aac ggt ggt act cca gca ggt act tca      367
 Asp Lys Asp Leu Ile Leu Pro Asn Gly Gly Thr Pro Ala Gly Thr Ser
                  55                  60                  65

 agt cca gct tct tca tct tcc ctt ctc aac aga ctt cag ctt gat gat      415
 Ser Pro Ala Ser Ser Ser Ser Leu Leu Asn Arg Leu Gln Leu Asp Asp
              70                  75                  80

 gat att gat ggt gag act aga gat ctc ttc gtt ata gtc gat gat ccc      463
 Asp Ile Asp Gly Glu Thr Arg Asp Leu Phe Val Ile Val Asp Asp Pro
          85                  90                  95

 aag aag cat gtg tgt aca atg gag act tac atc acc tat agg atc acc      511
 Lys Lys His Val Cys Thr Met Glu Thr Tyr Ile Thr Tyr Arg Ile Thr
     100                 105                 110

 acc aaa agt act cgg gtg gag ttt gac ctg cca gaa tat tct gtt cgt      559
 Thr Lys Ser Thr Arg Val Glu Phe Asp Leu Pro Glu Tyr Ser Val Arg
 115                 120                 125                 130

 cga aga tac cag gat ttt gac tgg ttg agg agc aaa ctg gaa gaa tcc      607
 Arg Arg Tyr Gln Asp Phe Asp Trp Leu Arg Ser Lys Leu Glu Glu Ser
                 135                 140                 145

 cag ccc act cat ctc att ccc cct ctt ccc gag aag ttt gtg gta aaa      655
 Gln Pro Thr His Leu Ile Pro Pro Leu Pro Glu Lys Phe Val Val Lys
             150                 155                 160

 ggt gtt gtg gat cgt ttt tca gaa gag ttt gtg gag acc aga aga aaa      703
 Gly Val Val Asp Arg Phe Ser Glu Glu Phe Val Glu Thr Arg Arg Lys
         165                 170                 175

 gct ttg gat aaa ttt cta aaa aga att acg gac cat cct gtg ctg tct      751
 Ala Leu Asp Lys Phe Leu Lys Arg Ile Thr Asp His Pro Val Leu Ser
     180                 185                 190

 ttc aat gaa cac ttt aat att ttc ctt act gct aag gac ctg aac gcc      799
 Phe Asn Glu His Phe Asn Ile Phe Leu Thr Ala Lys Asp Leu Asn Ala
 195                 200                 205                 210

 tac aag aag caa ggg ata gca ttg ctg acc aga atg ggc gag tca gtc      847
 Tyr Lys Lys Gln Gly Ile Ala Leu Leu Thr Arg Met Gly Glu Ser Val
                 215                 220                 225

 aag cac gtc act ggc ggc tac aag ctg agg act cgg ccg ctt gag ttt      895
 Lys His Val Thr Gly Gly Tyr Lys Leu Arg Thr Arg Pro Leu Glu Phe
             230                 235                 240

 gct gcc ata ggt gac tac tta gat aca ttt gca ctc aaa ctg gga acc      943
 Ala Ala Ile Gly Asp Tyr Leu Asp Thr Phe Ala Leu Lys Leu Gly Thr
         245                 250                 255

 att gat cga ata gcc cag cgg atc atc aaa gaa gaa ata gag tac ctt      991
 Ile Asp Arg Ile Ala Gln Arg Ile Ile Lys Glu Glu Ile Glu Tyr Leu
     260                 265                 270

 gtg gag ctg aga gaa tac ggg cct gtg tac tcc aca tgg agc gcc ttg     1039
 Val Glu Leu Arg Glu Tyr Gly Pro Val Tyr Ser Thr Trp Ser Ala Leu
 275                 280                 285                 290

 gag ggt gag ctg gct gaa ccc ctg gag ggt gtg tca gct tgc att ggg     1087
 Glu Gly Glu Leu Ala Glu Pro Leu Glu Gly Val Ser Ala Cys Ile Gly
                 295                 300                 305

 aac tgc tct aca gcc tta gaa gag ctg aca gat gac atg aca gaa gac     1135
 Asn Cys Ser Thr Ala Leu Glu Glu Leu Thr Asp Asp Met Thr Glu Asp
             310                 315                 320

 ttc cta cct gtg ctc agg gaa tat att tta tac tct gac tcc atg aag     1183
 Phe Leu Pro Val Leu Arg Glu Tyr Ile Leu Tyr Ser Asp Ser Met Lys
         325                 330                 335

 agt gta ttg aag aag agg gac caa gtt caa gca gag tat gaa gcc aaa     1231
 Ser Val Leu Lys Lys Arg Asp Gln Val Gln Ala Glu Tyr Glu Ala Lys
     340                 345                 350

 ctg gaa gct gtg gct ctg cgg aag gaa gac cgc ccc aag gta ccg gcg     1279
 Leu Glu Ala Val Ala Leu Arg Lys Glu Asp Arg Pro Lys Val Pro Ala
 355                 360                 365                 370

 gac gtc gag aaa tgt cag gat cgg atg gag tgt ttc aat gct gac ctg     1327
 Asp Val Glu Lys Cys Gln Asp Arg Met Glu Cys Phe Asn Ala Asp Leu
                 375                 380                 385

 aaa gct gac atg gag agg tgg cag aac aac aag agg cag gac ttc cgg     1375
 Lys Ala Asp Met Glu Arg Trp Gln Asn Asn Lys Arg Gln Asp Phe Arg
             390                 395                 400

 cag cta ctc atg ggg atg gct gac aag aac atc cag tat tta tga aga     1423
 Gln Leu Leu Met Gly Met Ala Asp Lys Asn Ile Gln Tyr Leu 
         405                 410                 415

 acgtgcctca tgccgacggc agtcgattat ttcccataat gcacgccaca accagaggcc   1483

 actaaagtct ttctggcgga cggaccctct tacttaaccg gcctggccct atccggaatt   1543

 tcctacatgc agagaccatg cggcaaacac ccacacacta ctctatatct atgcagccaa   1603

 atcctccact gccactcctc ccgccgctac acaccca                            1640




      <210> 295
      <211> 2753
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1248)

      <400> 295
  atg tcg tac aga cga gaa cta gag aaa tac cgt gac ctg gat gaa gat      48
  Met Ser Tyr Arg Arg Glu Leu Glu Lys Tyr Arg Asp Leu Asp Glu Asp
    1               5                  10                  15

 gaa atc ctt gga gcc cta aca gag gaa gag ctg agg acc ctg gaa aat       96
 Glu Ile Leu Gly Ala Leu Thr Glu Glu Glu Leu Arg Thr Leu Glu Asn
              20                  25                  30

 gag ctg gat gag ctg gac cct gat ttc aaa gaa aag aga aga gaa acc      144
 Glu Leu Asp Glu Leu Asp Pro Asp Phe Lys Glu Lys Arg Arg Glu Thr
          35                  40                  45

 aga gag agg ata gga gat aat gga ggc cag cat aca gtg atc ttc ata      192
 Arg Glu Arg Ile Gly Asp Asn Gly Gly Gln His Thr Val Ile Phe Ile
      50                  55                  60

 tcc ctg ata aca gtc ccc tca cag agg cag ctt tca gaa aag gat atg      240
 Ser Leu Ile Thr Val Pro Ser Gln Arg Gln Leu Ser Glu Lys Asp Met
  65                  70                  75                  80

 gag ttt gtg aca gtg act gaa gat atg cat ttt aat ggt aca aag att      288
 Glu Phe Val Thr Val Thr Glu Asp Met His Phe Asn Gly Thr Lys Ile
                  85                  90                  95

 gaa agt ggg gct ggg aac ggc ctg agg cag aag gat cag acc acc aag      336
 Glu Ser Gly Ala Gly Asn Gly Leu Arg Gln Lys Asp Gln Thr Thr Lys
             100                 105                 110

 gcg ccc acg ggc ccc ttt aaa aga gag gag ctc ttg gat cac ttg gaa      384
 Ala Pro Thr Gly Pro Phe Lys Arg Glu Glu Leu Leu Asp His Leu Glu
         115                 120                 125

 aag caa gca aag gag ttt aag gac cga gaa gat ctg gtc ccc tac aca      432
 Lys Gln Ala Lys Glu Phe Lys Asp Arg Glu Asp Leu Val Pro Tyr Thr
     130                 135                 140

 ggg gaa aaa cga gga aag gtc tgg gtt cct aag cag aag cca ctg gat      480
 Gly Glu Lys Arg Gly Lys Val Trp Val Pro Lys Gln Lys Pro Leu Asp
 145                 150                 155                 160

 cct gtg ctg gaa agt gtg acg ctg gaa ccg gag ctg gag gaa gcc ttg      528
 Pro Val Leu Glu Ser Val Thr Leu Glu Pro Glu Leu Glu Glu Ala Leu
                 165                 170                 175

 gca aat gct tca gat gca gaa ctc tgt gac att gca gcg atc ctg ggc      576
 Ala Asn Ala Ser Asp Ala Glu Leu Cys Asp Ile Ala Ala Ile Leu Gly
             180                 185                 190

 atg cac acg ctc atg agt aac cag cag tac tac cag gcc ctg agc agc      624
 Met His Thr Leu Met Ser Asn Gln Gln Tyr Tyr Gln Ala Leu Ser Ser
         195                 200                 205

 agc tcc atc atg aac aag gag ggg ctc aac agc gtg att aaa ccc aca      672
 Ser Ser Ile Met Asn Lys Glu Gly Leu Asn Ser Val Ile Lys Pro Thr
     210                 215                 220

 caa tac aag cct gtg ccc gac gaa gaa cca aat tca aca gac gta gag      720
 Gln Tyr Lys Pro Val Pro Asp Glu Glu Pro Asn Ser Thr Asp Val Glu
 225                 230                 235                 240

 gaa acg ctg gaa cgg ata aag aac aac gac cca aaa ctt gaa gaa gtt      768
 Glu Thr Leu Glu Arg Ile Lys Asn Asn Asp Pro Lys Leu Glu Glu Val
                 245                 250                 255

 aac ctc aat aat atc cgg aat atc ccc atc ccc acc ctc aag gca tat      816
 Asn Leu Asn Asn Ile Arg Asn Ile Pro Ile Pro Thr Leu Lys Ala Tyr
             260                 265                 270

 gca gaa gcc ctg aaa gaa aac tca tat gtg aag aag ttc agc atc gtg      864
 Ala Glu Ala Leu Lys Glu Asn Ser Tyr Val Lys Lys Phe Ser Ile Val
         275                 280                 285

 ggg aca cgg agt aat gac ccc gtg gcg tat gcc ctt gct gag atg ctc      912
 Gly Thr Arg Ser Asn Asp Pro Val Ala Tyr Ala Leu Ala Glu Met Leu
     290                 295                 300

 aag gag aac aag gtg ttg aag aca ctg aat gtg gaa tcc aac ttc att      960
 Lys Glu Asn Lys Val Leu Lys Thr Leu Asn Val Glu Ser Asn Phe Ile
 305                 310                 315                 320

 tct gga gct ggg att ctg cgc ctg gta gaa gcc ctc cca tac aac act     1008
 Ser Gly Ala Gly Ile Leu Arg Leu Val Glu Ala Leu Pro Tyr Asn Thr
                 325                 330                 335

 tct ctg gtg gaa atg aaa att gac aac cag agc cag ccc ctg ggc aac     1056
 Ser Leu Val Glu Met Lys Ile Asp Asn Gln Ser Gln Pro Leu Gly Asn
             340                 345                 350

 aaa gtg gaa atg gag att gtg agc atg ttg gaa aaa aac gca aca ctt     1104
 Lys Val Glu Met Glu Ile Val Ser Met Leu Glu Lys Asn Ala Thr Leu
         355                 360                 365

 ctc aaa ttc ggc tac cac ttt acc cag caa gga ccc cgg ctt cgg gca     1152
 Leu Lys Phe Gly Tyr His Phe Thr Gln Gln Gly Pro Arg Leu Arg Ala
     370                 375                 380

 tcc aac gca atg atg aac aac aat gac ctt gtg agg aag agg agg ctt     1200
 Ser Asn Ala Met Met Asn Asn Asn Asp Leu Val Arg Lys Arg Arg Leu
 385                 390                 395                 400

 gcg gac ctg act ggg ccc atc att ccc aag tgc cgg agt ggt gtc tag     1248
 Ala Asp Leu Thr Gly Pro Ile Ile Pro Lys Cys Arg Ser Gly Val 
                 405                 410                 415

 tgtgtggcgg tggagtccat gcctttgaac tggatgtgtt ctattgatga cctgtgctct   1308

 gcaggggaaa ccagaaggca aaatgctggc agcatgaaac ccttttgtgg ttcagttctt   1368

 tatgcactaa ggttttaggt tgactagtgg ttgtagttga aaattttata aaataccgtt   1428

 aatgtgaagt ttttctttag tcacagaagt tgaatctggt tattatttaa aaactagaag   1488

 cccccaaacc agcagatctt actgaagatg atgttccagc agcagcgact tagccccagg   1548

 agcccagttt caatggcctt gctgtgtggt gtttcaagtg catttaaaat gtgtgacaca   1608

 gaaacggcac actcttccac atgcttttga agtattataa aacactttat tacaaatttg   1668

 tcttagctat tagcaaataa aactgattat cattctttat taaccctcct tggaattttg   1728

 aaaacctcga ttaaagttgc caaattgatt actggatcca gaacacaatt ttcccctcag   1788

 aacagataga cagactgaag ccactgaact ctgccaggag tcaacatgag attccttttg   1848

 ctggatatgc agaaatgata ggaaaaaaac caatggtgaa atttcaagtt tcaaaaacca   1908

 acctttcatt accaatccca ggcaacaaac atgtccctga gtgttcttta agaacatttg   1968

 ggatttatgt acaatttaat actggagtta gaactttttc cttattgaat gccaacctta   2028

 tgatggatgt gaaaatctac ggccaaatac ttttgaaaac acctttctat attgcacagt   2088

 gggcaaatgg cttatgtgag gtaagacact agagggataa atttccagat caacatggct   2148

 atggtattta gtaatggccc agcttagaga cttcagctac tgatctcatc acttattaga   2208

 caaattgctg ctgaccttac gcctgtatat taagcctccg caggatgccg gacaatggtg   2268

 aagaaactcc agatatcaag gaattgggaa atcctggcca aaccacccca agatgattac   2328

 actgaaatgt agtattagta ctgctgccag atctcttttt aacatcatgt gcgtctcttg   2388

 ggatccagca aaagtgttaa gccacaatgc ccttgtgcct tttaatatac cacagtgcca   2448

 gttaaactaa tatttttgtt tgttgctttt gggagttatt ttcattagtg atttcagcaa   2508

 atctcatgat aaaggacaag gtcaagaact ccagagcact gagcagagag gctggtgatg   2568

 aaaaggtgaa ggcctgcgca ctgaactgta aggcagtggg cagtacaggg taactggagg   2628

 cggggccagg gcctcagcgc tatggaagag tgtccactga ggctgcacat ggcccaggag   2688

 tggcaccatg ttgcagggac aaccatcccc atttggcttc tccttaaaac acaattgcag   2748

 ctgca                                                               2753




      <210> 296
      <211> 948
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (262)..(948)

      <400> 296
 agaactgagt gtgagggaga tcacttaaaa ctctagtcaa ggtgacctgg gtataatctc     60

 aaagagagga ttggagtgtg gctgaaaaaa tgatacttgt tattacatgt accagacatt    120

 attcttagga ctactttcag aagtaggtat ttttattgtt ccctttttgt agatgaaaaa    180

 ataggcttaa agaggttaag tgtaacttgc ttaagatcac acacacagag taagtggcag    240

 tactatctgg ttgcagagct c  atg ctc ttt ccc att caa gct tat aca gtc     291
                          Met Leu Phe Pro Ile Gln Ala Tyr Thr Val
                            1               5                  10

 tta gag agg ttt gat gac aag atc cag att cct caa cct att aat aca      339
 Leu Glu Arg Phe Asp Asp Lys Ile Gln Ile Pro Gln Pro Ile Asn Thr
                  15                  20                  25

 aag tgg aaa aag aaa aaa gaa gag gcc tac aac ttg gat tgc tat gaa      387
 Lys Trp Lys Lys Lys Lys Glu Glu Ala Tyr Asn Leu Asp Cys Tyr Glu
              30                  35                  40

 ttc acc aag gtc aca aaa gat gtc ata aaa gaa ttt gca gat gac ggc      435
 Phe Thr Lys Val Thr Lys Asp Val Ile Lys Glu Phe Ala Asp Asp Gly
          45                  50                  55

 gtc aag tac ctg gaa cta agg agc aca ccc aga aga gaa aat gct act      483
 Val Lys Tyr Leu Glu Leu Arg Ser Thr Pro Arg Arg Glu Asn Ala Thr
      60                  65                  70

 gga atg act aaa aag act tat gtg gaa tct ata ctt gaa ggt ata aaa      531
 Gly Met Thr Lys Lys Thr Tyr Val Glu Ser Ile Leu Glu Gly Ile Lys
  75                  80                  85                  90

 cag tcc aaa caa gaa aac ttg gac att gat gtt aga atc ggg cat gga      579
 Gln Ser Lys Gln Glu Asn Leu Asp Ile Asp Val Arg Ile Gly His Gly
                  95                 100                 105

 aca ttt ctc aac tcc ggt gag gga gga tcc ctg gat ctg gtg gac ttt      627
 Thr Phe Leu Asn Ser Gly Glu Gly Gly Ser Leu Asp Leu Val Asp Phe
             110                 115                 120

 gtg agg caa cat cgg ata cca ctg gaa ctc tgt ttg acc tca aac gtc      675
 Val Arg Gln His Arg Ile Pro Leu Glu Leu Cys Leu Thr Ser Asn Val
         125                 130                 135

 aaa agt cag aca gtt cca tct tat gac cag cac cat ttc gga ttc tgg      723
 Lys Ser Gln Thr Val Pro Ser Tyr Asp Gln His His Phe Gly Phe Trp
     140                 145                 150

 tac agc att gcc cat cct tct gtg atc tgt act gat gat aag ggt gtt      771
 Tyr Ser Ile Ala His Pro Ser Val Ile Cys Thr Asp Asp Lys Gly Val
 155                 160                 165                 170

 ttt gca aca cac ctt tct caa gag tac cag ctg gca gct gaa aca ttt      819
 Phe Ala Thr His Leu Ser Gln Glu Tyr Gln Leu Ala Ala Glu Thr Phe
                 175                 180                 185

 aat ttg acc cag tct cag gtg tgg gat ctg tct tat gaa tcc atc aac      867
 Asn Leu Thr Gln Ser Gln Val Trp Asp Leu Ser Tyr Glu Ser Ile Asn
             190                 195                 200

 tac atc ttt gct tct gac agc acc aga tct gaa ctg agg aag aaa tgg      915
 Tyr Ile Phe Ala Ser Asp Ser Thr Arg Ser Glu Leu Arg Lys Lys Trp
         205                 210                 215

 aat cac ctg aag ccc aga gtg tta cat att taa                          948
 Asn His Leu Lys Pro Arg Val Leu His Ile 
     220                 225





      <210> 297
      <211> 2610
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (95)..(1108)

      <400> 297
 aaggatcctt aattaaatta atcccccccc ccccccgctt cctctttctc gactccatct     60

 tcgcggtagc tgggaccgcc gttcagtcgc caat    atg cag ctc ttt gtc cgc     112
                                          Met Gln Leu Phe Val Arg
                                            1               5

 gcc cag gag cta cac acc ttc gag gtg acc ggc cag gaa acg gtc gcc      160
 Ala Gln Glu Leu His Thr Phe Glu Val Thr Gly Gln Glu Thr Val Ala
              10                  15                  20

 cag atc aag gct cat gta gcc tca ctg gag ggc att gcc ccg gaa gat      208
 Gln Ile Lys Ala His Val Ala Ser Leu Glu Gly Ile Ala Pro Glu Asp
          25                  30                  35

 caa gtc gtg ctc ctg gca ggc gcg ccc ctg gag gat gag gcc act ctg      256
 Gln Val Val Leu Leu Ala Gly Ala Pro Leu Glu Asp Glu Ala Thr Leu
      40                  45                  50

 ggc cag tgc ggg gtg gag gcc ctg act acc ctg gaa gta gca ggc cgc      304
 Gly Gln Cys Gly Val Glu Ala Leu Thr Thr Leu Glu Val Ala Gly Arg
  55                  60                  65                  70

 atg ctt gga ggt aaa gtc cat ggt tcc ctg gcc cgt gct gga aaa gtg      352
 Met Leu Gly Gly Lys Val His Gly Ser Leu Ala Arg Ala Gly Lys Val
                  75                  80                  85

 aga ggt cag act cct aag gtg gcc aaa cag gag aag aag aag aag aag      400
 Arg Gly Gln Thr Pro Lys Val Ala Lys Gln Glu Lys Lys Lys Lys Lys
              90                  95                 100

 aca ggt cgg gct aag cgg cgg atg cag tac aac cgg cgc ttt gtc aac      448
 Thr Gly Arg Ala Lys Arg Arg Met Gln Tyr Asn Arg Arg Phe Val Asn
         105                 110                 115

 gtt gtg ccc acc ttt ggc aag aag aag ggc acc acg ttc acc aag atc      496
 Val Val Pro Thr Phe Gly Lys Lys Lys Gly Thr Thr Phe Thr Lys Ile
     120                 125                 130

 ttc gtg ggc ggc ctg ccg tac cac act acc gac gcc tcg ctc agg aag      544
 Phe Val Gly Gly Leu Pro Tyr His Thr Thr Asp Ala Ser Leu Arg Lys
 135                 140                 145                 150

 tac ttc gag ggc ttc ggc gac atc gag gag gcc gtg gtc atc acc gac      592
 Tyr Phe Glu Gly Phe Gly Asp Ile Glu Glu Ala Val Val Ile Thr Asp
                 155                 160                 165

 cgc cag acg ggc aag tcc cgc ggc tac ggc ttc gtg acc atg gcc gac      640
 Arg Gln Thr Gly Lys Ser Arg Gly Tyr Gly Phe Val Thr Met Ala Asp
             170                 175                 180

 cgg gcg gca gct gag agg gct tgc aaa gac ccg aac ccc atc atc gac      688
 Arg Ala Ala Ala Glu Arg Ala Cys Lys Asp Pro Asn Pro Ile Ile Asp
         185                 190                 195

 ggc cgc aag gcc aac gtg aac ctg gca tat ctg ggc gcc aag ccg cgg      736
 Gly Arg Lys Ala Asn Val Asn Leu Ala Tyr Leu Gly Ala Lys Pro Arg
     200                 205                 210

 agc ctc cag acg ggc ttt gcc att ggg gtg cag cag ctg cac ccc acc      784
 Ser Leu Gln Thr Gly Phe Ala Ile Gly Val Gln Gln Leu His Pro Thr
 215                 220                 225                 230

 ttg atc cag cgg act tac ggg ctg acc ccg cac tac atc tac cca cca      832
 Leu Ile Gln Arg Thr Tyr Gly Leu Thr Pro His Tyr Ile Tyr Pro Pro
                 235                 240                 245

 gcc atc gtg cag ccc agc gtg gtg atc cca gcc gcc cct gtc ccg tcg      880
 Ala Ile Val Gln Pro Ser Val Val Ile Pro Ala Ala Pro Val Pro Ser
             250                 255                 260

 ctg tcc tcg ccc tac att gag tac acg ccg gcc agc ccg gcc tac gcc      928
 Leu Ser Ser Pro Tyr Ile Glu Tyr Thr Pro Ala Ser Pro Ala Tyr Ala
         265                 270                 275

 cag tac cca ccg gcc acc tat gac cag tac cca tac gcc gcc tcg cct      976
 Gln Tyr Pro Pro Ala Thr Tyr Asp Gln Tyr Pro Tyr Ala Ala Ser Pro
     280                 285                 290

 gcc acg gct gcc agc ttc gtg ggc tac agc tac cct gcc gcc gtg ccc     1024
 Ala Thr Ala Ala Ser Phe Val Gly Tyr Ser Tyr Pro Ala Ala Val Pro
 295                 300                 305                 310

 cag gcc ctc tca gcc gca gca ccc gcg ggc acc act ttc gtg cag tac     1072
 Gln Ala Leu Ser Ala Ala Ala Pro Ala Gly Thr Thr Phe Val Gln Tyr
                 315                 320                 325

 cag gcg ccg cag ctg cag cct gac agg atg cag tga gggg cgttcctgcc     1122
 Gln Ala Pro Gln Leu Gln Pro Asp Arg Met Gln 
             330                 335

 ccgaggactg tggcattgtc accttcacag cagacagagc tgccaggcca tgatgggctg   1182

 gcgacagccc ggctgagctt cagtgaggtg ccaccagcac ccgtgcctcc gaagaccgct   1242

 cgggcattcc gcctgcgccc tgggacagcg gagagatggc ttctctttaa tctaggtccc   1302

 attgtgtctt gagggaggac tttaagaatg actgagaact atttaaagac gcaatcccag   1362

 gttccttgca caccatggca gcctctcctt gcaccttctc ctgcctctcc acactccagg   1422

 ttccctcagg cttgtgtccc cactgctgca tcgtggcggg gtgtcacaga ccctctgcag   1482

 cccctggctg ccctggactg tgcagagatg cctgactcca gggaaacctg aaagcaagaa   1542

 gttaatggac tgtttattgt aacttgatcc tcccgagctg tgagcgcagt ctgaggtgtg   1602

 aggacacggc ctcctgttgg agtcccattt tctccatcag ggcacgtggg cggcttcctc   1662

 aagcccggag gagctcccag gcgcacaggg gccgccggta acaggggccg ccggccaaag   1722

 gcccctttcc agtcatagca ctgaagttgc aacttttttc ttgtaattgt tttgctacta   1782

 agataatttc agaagttcag tctatttttt cagcggatac tgccgccacc aagaatccaa   1842

 aacctatttt tgacttggag agacttgctt ttgttggttc cgcccgtgga gacgacgata   1902

 gtgtttctgt ataataaagt gtctgccggc tcgcgggcca ggatcctctc ggtgggatgg   1962

 gcaccacaga caggaggccc ctcaggcccg tgcgggccac tgtctgctgc cgcctgccgg   2022

 ggtggcagag tgagttgtct caggaccccg tcactgcgac gttgacactc ctctcccttc   2082

 ccttcctccc caactcccca aacactgtgg aaggggagaa ggaagtgatc cacagcattc   2142

 aggccacttg gggtctagac catggtggtg ccagcctggg gggggcagtg gccctcagct   2202

 ctgcccgctg gagcggttga gtgcagaagg gtgcgcctct tccctctacc cccgcaccac   2262

 ctgctgtgtg ccagcctgag acggttcctg cctgtcttgg gggttggtgg agggtggagg   2322

 cagttctgcc agccgtggca gggctgctat ggggcatcca gggctgtggg ggtctggagg   2382

 aggggacatg aggtgagagg tatcctggcc gagggcgggg ggcagcgggg ggtctccctc   2442

 cggacctacc tcagggagct gagcgtgcag gcgctccagg gcaggcctgg gacagagtca   2502

 aggctcagag aataaaggta gctaatctca tcataatatt tttattagaa tgttctgatg   2562

 ataaaaataa aacttgtttt ctttaaagaa aaaaaaaaaa aaacctat                2610




      <210> 298
      <211> 2476
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1067)..(2422)

      <400> 298
 gaataaggag aaccctcaca caaagggtca tggtctcttt cccatggatg aggggcccag     60

 caccatggcc agggccacag ccacctcgtg ccacacagca gccaaaccag gcccccccac    120

 catcacatat ccccttccac caaggcggcc tgtgagcgcc aacaaggaga tgttctcgtt    180

 cgtggtggac gacgcccgca agccacccgt catcaagcaa gtgtggacca atgccatgaa    240

 actgtcagaa aaatcagtgg ccgaggggat tcctggggca gttccccctg cggagattta    300

 tgtggaggag gacttggccc agcaggacaa ggatgaaata attctgctgc tgggaaaaga    360

 ggtcagccgt ctctcagatt atgaaattga atccaaatac aaagacgtca taatagcaaa    420

 cctgcagaat gaagtggctg agctgagtca gaaggtgtca gagaccacca cctccaggca    480

 gaatgagaag gagatctcgc agaagtgtca ggttctggat gaagacatcg atgccaaaca    540

 gaaagagatc cagagcttga aaagccagat cagtgcccta cagaaaggct acagcaaggt    600

 gctgtgccag accctgtcag agcggaactc agaaatcaca tccctgaaga atgagggcga    660

 gaacttaaag agagacaacg ctatcacatc agggatggtg tcatctttgc aaaaagacat    720

 attagcaaag gatgagcaag ttcaacaact aaaggaagag gtcagtcacc taaaaagtca    780

 gaacaaggac aaggaccacc agctggaagc ccttggctct agactggagc acttcagaag    840

 tcaagtcatc aaggccacct atggacgggc gaagccgttc cgggacaagc ccgtcaccga    900

 ccaacagtta atagagaaaa ttacccaggt cactgaggac aacatcaatt ttcagcagaa    960

 aaagtggacc ctccagaaag agacccagct gagcaactcc aagcaggagg agaccaccga   1020

 gaacatcgag aagctgagga cgtcgctgga cagctgccag gcttgc   atg aaa ata    1075
                                                      Met Lys Ile
                                                        1

 tcc tgt tgc agc cat gac ctg aag aag gag gtc gac ctt ctt cag cac     1123
 Ser Cys Cys Ser His Asp Leu Lys Lys Glu Val Asp Leu Leu Gln His
       5                  10                  15

 ctc cag gtg agc cca cct gtc tcg ggg ctc cag aag gtg gtg ctg gac     1171
 Leu Gln Val Ser Pro Pro Val Ser Gly Leu Gln Lys Val Val Leu Asp
  20                  25                  30                  35

 gtc ctg agg cac gcg ctg tcc tgg ctg gag gag gtg gag cag ctc ctc     1219
 Val Leu Arg His Ala Leu Ser Trp Leu Glu Glu Val Glu Gln Leu Leu
                  40                  45                  50

 cgg gac ctc ggg atc ctg ccc tcc agc ccc aac aaa ggt aat aat gat     1267
 Arg Asp Leu Gly Ile Leu Pro Ser Ser Pro Asn Lys Gly Asn Asn Asp
              55                  60                  65

 gta tcc tca gca ccc aga gag cat gtg cca cac agc ggg ggc cta ata     1315
 Val Ser Ser Ala Pro Arg Glu His Val Pro His Ser Gly Gly Leu Ile
          70                  75                  80

 cat atc tgt ggg ttg gag gga tgg atg gaa gga agt gca gat gga tgg     1363
 His Ile Cys Gly Leu Glu Gly Trp Met Glu Gly Ser Ala Asp Gly Trp
      85                  90                  95

 atg gac gga cgg atg gaa gaa agg atg gat gga agc att ggt ggg tgg     1411
 Met Asp Gly Arg Met Glu Glu Arg Met Asp Gly Ser Ile Gly Gly Trp
 100                 105                 110                 115

 gtg gat gga tgg atg gac gga cgg gtg gaa gaa aga atg gat gga agg     1459
 Val Asp Gly Trp Met Asp Gly Arg Val Glu Glu Arg Met Asp Gly Arg
                 120                 125                 130

 atc aag ttc aac agt tct cag gaa act cag cag tct tta ctg cag gaa     1507
 Ile Lys Phe Asn Ser Ser Gln Glu Thr Gln Gln Ser Leu Leu Gln Glu
             135                 140                 145

 aag ctg cgg gag cat ctg gca gag aag gag aag ctg aac gag gag agg     1555
 Lys Leu Arg Glu His Leu Ala Glu Lys Glu Lys Leu Asn Glu Glu Arg
         150                 155                 160

 cta gag caa gag gag aag ctc aaa gcc aaa atc agg caa ctg acg gaa     1603
 Leu Glu Gln Glu Glu Lys Leu Lys Ala Lys Ile Arg Gln Leu Thr Glu
     165                 170                 175

 gag aag gcg gct ttg gag gag tac att act caa gag aga aac aga gcg     1651
 Glu Lys Ala Ala Leu Glu Glu Tyr Ile Thr Gln Glu Arg Asn Arg Ala
 180                 185                 190                 195

 aaa gag act tta gag gaa gaa cgg aag aga atg caa gaa ctg gag agc     1699
 Lys Glu Thr Leu Glu Glu Glu Arg Lys Arg Met Gln Glu Leu Glu Ser
                 200                 205                 210

 ctc ctg gcc cag cag aag aag gct ttg gcg aaa agc att acc cag gag     1747
 Leu Leu Ala Gln Gln Lys Lys Ala Leu Ala Lys Ser Ile Thr Gln Glu
             215                 220                 225

 aag aac aga gtg aag gaa gca tta gag gaa gag cag aca aga gtc caa     1795
 Lys Asn Arg Val Lys Glu Ala Leu Glu Glu Glu Gln Thr Arg Val Gln
         230                 235                 240

 gag ctg gag gaa cgc ttg gcc cgc cag aag gag atc tca gag agc aac     1843
 Glu Leu Glu Glu Arg Leu Ala Arg Gln Lys Glu Ile Ser Glu Ser Asn
     245                 250                 255

 att gcg tac gag aaa cgc aaa gca aag gag gcc atg gag aag gaa aag     1891
 Ile Ala Tyr Glu Lys Arg Lys Ala Lys Glu Ala Met Glu Lys Glu Lys
 260                 265                 270                 275

 aaa aag gtg caa gac ctg gag aat cgc tta acc aag cag aaa gag gaa     1939
 Lys Lys Val Gln Asp Leu Glu Asn Arg Leu Thr Lys Gln Lys Glu Glu
                 280                 285                 290

 tta gaa tta aaa gag caa aaa gag gac gtt tta aat aat aaa tta agt     1987
 Leu Glu Leu Lys Glu Gln Lys Glu Asp Val Leu Asn Asn Lys Leu Ser
             295                 300                 305

 gac gca ctg gcc atg gtt gaa gag act cag aaa aca aag gca act gaa     2035
 Asp Ala Leu Ala Met Val Glu Glu Thr Gln Lys Thr Lys Ala Thr Glu
         310                 315                 320

 agt cta aaa gca gag agc ctc gcc ttg aaa tta aat gaa aca tta gcc     2083
 Ser Leu Lys Ala Glu Ser Leu Ala Leu Lys Leu Asn Glu Thr Leu Ala
     325                 330                 335

 gaa ctg gaa act acc aag aca aaa atg atc atg gtg gaa gag cgg cta     2131
 Glu Leu Glu Thr Thr Lys Thr Lys Met Ile Met Val Glu Glu Arg Leu
 340                 345                 350                 355

 atc ctg cag cag aag atg gta aag gcc ctc cag gat gag cag gaa tca     2179
 Ile Leu Gln Gln Lys Met Val Lys Ala Leu Gln Asp Glu Gln Glu Ser
                 360                 365                 370

 cag aga cac ggg ttt gaa gaa gag atc atg gaa tat aag gag caa atc     2227
 Gln Arg His Gly Phe Glu Glu Glu Ile Met Glu Tyr Lys Glu Gln Ile
             375                 380                 385

 aaa cag cac gcc cag aca att gtg agc ctc gaa gag aaa ctc cag aaa     2275
 Lys Gln His Ala Gln Thr Ile Val Ser Leu Glu Glu Lys Leu Gln Lys
         390                 395                 400

 gtc act cag cac cat aaa aaa ata gaa ggc gag att gca aca ttg aag     2323
 Val Thr Gln His His Lys Lys Ile Glu Gly Glu Ile Ala Thr Leu Lys
     405                 410                 415

 gac aat gac cca ggc caa ggg gaa aag ggg gag gac ctc ggg tgg gtc     2371
 Asp Asn Asp Pro Gly Gln Gly Glu Lys Gly Glu Asp Leu Gly Trp Val
 420                 425                 430                 435

 cct gac gaa gag ccg ggc cag aac tgg ggt ccg agc tct gtt gtg ctc     2419
 Pro Asp Glu Glu Pro Gly Gln Asn Trp Gly Pro Ser Ser Val Val Leu
                 440                 445                 450

 tag agtt ttctccgagt gcggtttcca aacacgtttt ttggagacca aaggttctaa     2476
 






      <210> 299
      <211> 7493
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (236)..(7450)

      <400> 299
 actactacta ctaaattcgc ggccgctcga cgtccctcct tctgagccat cagcaactag     60

 gcgactacag gaaacttact ccaaattgct actagaaaag accttgcttg aagagccatc    120

 tcatcaacat gttacgcagg aaacacaggc caaaccaggg tatcagccat ctggagaatc    180

 tgacaaagaa aacaaagtac aggaacgtcc cccaagtgca tcttccagta gtgac atg     238
                                                              Met
                                                                1

 tct ctc tca gaa cct cca cag cct ctt gca aga aaa gac ttg atg gaa      286
 Ser Leu Ser Glu Pro Pro Gln Pro Leu Ala Arg Lys Asp Leu Met Glu
               5                  10                  15

 tct aca tgg atg cag cct gaa aga ttg agc cca caa gtt cac cat tct      334
 Ser Thr Trp Met Gln Pro Glu Arg Leu Ser Pro Gln Val His His Ser
          20                  25                  30

 caa cca cag cct ttt gct gga aca gct gga agt tta ctc tcc cat ctc      382
 Gln Pro Gln Pro Phe Ala Gly Thr Ala Gly Ser Leu Leu Ser His Leu
      35                  40                  45

 ttg agt tta gag cat gta gga att ttg cat aag gat ttt gaa tct att      430
 Leu Ser Leu Glu His Val Gly Ile Leu His Lys Asp Phe Glu Ser Ile
  50                  55                  60                  65

 tta cca acc agg aag aat cat aat atg gct tca agg cca tta act ttt      478
 Leu Pro Thr Arg Lys Asn His Asn Met Ala Ser Arg Pro Leu Thr Phe
                  70                  75                  80

 aca cct caa cca tat gtg acc tca cca gct gct tat aca gat gcc ttg      526
 Thr Pro Gln Pro Tyr Val Thr Ser Pro Ala Ala Tyr Thr Asp Ala Leu
              85                  90                  95

 tta aaa cct agt gcc agc caa tat aag agt aaa ctg gat cgt att gaa      574
 Leu Lys Pro Ser Ala Ser Gln Tyr Lys Ser Lys Leu Asp Arg Ile Glu
         100                 105                 110

 gcc ttg aaa gca aca gct gct tct ttg tcc agc aga att gaa agt gaa      622
 Ala Leu Lys Ala Thr Ala Ala Ser Leu Ser Ser Arg Ile Glu Ser Glu
     115                 120                 125

 gcc aag aaa tta gct ggg gcc agc att aac tat ggg tca gca tgg aac      670
 Ala Lys Lys Leu Ala Gly Ala Ser Ile Asn Tyr Gly Ser Ala Trp Asn
 130                 135                 140                 145

 act gag tat gat gtg cag cag gca cct caa gaa gat gga cct tgg acc      718
 Thr Glu Tyr Asp Val Gln Gln Ala Pro Gln Glu Asp Gly Pro Trp Thr
                 150                 155                 160

 aag gct gta act cca cct gtg aaa gat gat aat gaa gat gtt ttc tct      766
 Lys Ala Val Thr Pro Pro Val Lys Asp Asp Asn Glu Asp Val Phe Ser
             165                 170                 175

 gcc aga att cag aag atg ctg gga agc tgt gta tct cat gca act ttt      814
 Ala Arg Ile Gln Lys Met Leu Gly Ser Cys Val Ser His Ala Thr Phe
         180                 185                 190

 gat gat gat ctt cct ggt gta ggc aat ctt agt gaa ttt aaa aag ctt      862
 Asp Asp Asp Leu Pro Gly Val Gly Asn Leu Ser Glu Phe Lys Lys Leu
     195                 200                 205

 cct gag atg ata aga cca cag agt gcc ata tca agc ttt aga gtg aga      910
 Pro Glu Met Ile Arg Pro Gln Ser Ala Ile Ser Ser Phe Arg Val Arg
 210                 215                 220                 225

 tcc cct ggt ccc aaa cca gaa ggg cta ctg gca cag tta tgt aaa agg      958
 Ser Pro Gly Pro Lys Pro Glu Gly Leu Leu Ala Gln Leu Cys Lys Arg
                 230                 235                 240

 cag act gac tct tct agc tct gat atg caa gcc tgt tct caa gac aaa     1006
 Gln Thr Asp Ser Ser Ser Ser Asp Met Gln Ala Cys Ser Gln Asp Lys
             245                 250                 255

 gcc aaa ata tct ctt ggt tcc agc ata gat tca gtc agt gaa ggg cct     1054
 Ala Lys Ile Ser Leu Gly Ser Ser Ile Asp Ser Val Ser Glu Gly Pro
         260                 265                 270

 ctt ctt agt gag ggg agt ctc tct gaa gaa gag gga gac cag gat gga     1102
 Leu Leu Ser Glu Gly Ser Leu Ser Glu Glu Glu Gly Asp Gln Asp Gly
     275                 280                 285

 cag ccc ctt ttg aaa gta gca gaa att tta aaa gaa aag gaa ttt tgt     1150
 Gln Pro Leu Leu Lys Val Ala Glu Ile Leu Lys Glu Lys Glu Phe Cys
 290                 295                 300                 305

 cct gga gaa aga aat agt tat gaa ccc atc aaa gag ttt cag aaa gaa     1198
 Pro Gly Glu Arg Asn Ser Tyr Glu Pro Ile Lys Glu Phe Gln Lys Glu
                 310                 315                 320

 gct gaa aaa ttc ttg cca ctt ttt ggg cac ata ggt ggt aca caa agc     1246
 Ala Glu Lys Phe Leu Pro Leu Phe Gly His Ile Gly Gly Thr Gln Ser
             325                 330                 335

 aaa gga cca tgg gaa gaa ttg gca aag gga agt cca cat agc gtc att     1294
 Lys Gly Pro Trp Glu Glu Leu Ala Lys Gly Ser Pro His Ser Val Ile
         340                 345                 350

 aat att ttt aca aaa tcc tat cag tta tat gga aaa ggg ttt gaa gac     1342
 Asn Ile Phe Thr Lys Ser Tyr Gln Leu Tyr Gly Lys Gly Phe Glu Asp
     355                 360                 365

 aag ttg gac aga gga aca tca aca tca cgg cct ttg aat gcc acc gca     1390
 Lys Leu Asp Arg Gly Thr Ser Thr Ser Arg Pro Leu Asn Ala Thr Ala
 370                 375                 380                 385

 act cct cta agt ggt gtt tca tat gaa gat gat ttt gtc tcc tct cca     1438
 Thr Pro Leu Ser Gly Val Ser Tyr Glu Asp Asp Phe Val Ser Ser Pro
                 390                 395                 400

 ggg act ggg act tcg aca gaa aaa aaa tca act ctt gaa cct cat agc     1486
 Gly Thr Gly Thr Ser Thr Glu Lys Lys Ser Thr Leu Glu Pro His Ser
             405                 410                 415

 act tta agc cct cag gag gac cat tct aac aga aag tct gcc tat gat     1534
 Thr Leu Ser Pro Gln Glu Asp His Ser Asn Arg Lys Ser Ala Tyr Asp
         420                 425                 430

 cct tcc tct gtg gat gtt acc tcc cag cat tca tca gga gcc cag tct     1582
 Pro Ser Ser Val Asp Val Thr Ser Gln His Ser Ser Gly Ala Gln Ser
     435                 440                 445

 gct gca tcg tct cgt tca tct act tct tct aaa gga aag aaa gga aaa     1630
 Ala Ala Ser Ser Arg Ser Ser Thr Ser Ser Lys Gly Lys Lys Gly Lys
 450                 455                 460                 465

 aag gaa aag aca gaa tgg ttg gat tca ttc act gga aat gtt cag aac     1678
 Lys Glu Lys Thr Glu Trp Leu Asp Ser Phe Thr Gly Asn Val Gln Asn
                 470                 475                 480

 tca ctt ctt gat gag gaa aaa gca gaa cgt ggc tcc cat caa gga aag     1726
 Ser Leu Leu Asp Glu Glu Lys Ala Glu Arg Gly Ser His Gln Gly Lys
             485                 490                 495

 aaa tct ggg acc agc agc aaa ctt tct gtt aaa gat ttt gag cag act     1774
 Lys Ser Gly Thr Ser Ser Lys Leu Ser Val Lys Asp Phe Glu Gln Thr
         500                 505                 510

 ctt gat aca gat agc act ttg gag gat ctt tct gga cat tct gtg agt     1822
 Leu Asp Thr Asp Ser Thr Leu Glu Asp Leu Ser Gly His Ser Val Ser
     515                 520                 525

 gtc tca tca gat aag gga aga tct cag aaa act cca act tct ccc ctg     1870
 Val Ser Ser Asp Lys Gly Arg Ser Gln Lys Thr Pro Thr Ser Pro Leu
 530                 535                 540                 545

 tca cca agt tcc cag aaa tca ttg cag ttt gac gtt gca gga act tct     1918
 Ser Pro Ser Ser Gln Lys Ser Leu Gln Phe Asp Val Ala Gly Thr Ser
                 550                 555                 560

 tca gaa aga tct aag tcg tca gta atg cct cca act ata aca gga ttt     1966
 Ser Glu Arg Ser Lys Ser Ser Val Met Pro Pro Thr Ile Thr Gly Phe
             565                 570                 575

 aag cct aat gca cct ctc act gat ctg aac ccg gca gcc agc aga aca     2014
 Lys Pro Asn Ala Pro Leu Thr Asp Leu Asn Pro Ala Ala Ser Arg Thr
         580                 585                 590

 acg aca gag aac atg gct cca ata cca ggt tct aag cgc ttt tct cct     2062
 Thr Thr Glu Asn Met Ala Pro Ile Pro Gly Ser Lys Arg Phe Ser Pro
     595                 600                 605

 gct ggc ctc cat cat cgt atg gca gca gaa ctc agt tat ctg aac gcc     2110
 Ala Gly Leu His His Arg Met Ala Ala Glu Leu Ser Tyr Leu Asn Ala
 610                 615                 620                 625

 att gag gag tcg gtg cgc caa ctg tca gat gta gaa aga gtt aga ggc     2158
 Ile Glu Glu Ser Val Arg Gln Leu Ser Asp Val Glu Arg Val Arg Gly
                 630                 635                 640

 att tca ctt gct cag cag gag agt gtg tct cta gct cag ata ata aag     2206
 Ile Ser Leu Ala Gln Gln Glu Ser Val Ser Leu Ala Gln Ile Ile Lys
             645                 650                 655

 gca caa cag caa cgc cat gaa aga gac ttg gcc ctc ttg aaa cta aag     2254
 Ala Gln Gln Gln Arg His Glu Arg Asp Leu Ala Leu Leu Lys Leu Lys
         660                 665                 670

 gct gaa caa gag gct ctg gag agt cag aga caa tta gaa gaa acc cga     2302
 Ala Glu Gln Glu Ala Leu Glu Ser Gln Arg Gln Leu Glu Glu Thr Arg
     675                 680                 685

 aac aaa gca gct cag gtc cat gca gaa tca tta cag cag gtg gtt caa     2350
 Asn Lys Ala Ala Gln Val His Ala Glu Ser Leu Gln Gln Val Val Gln
 690                 695                 700                 705

 tca caa cgg gaa gta act gaa gtc ctg cag gaa gca acg tgt aaa ata     2398
 Ser Gln Arg Glu Val Thr Glu Val Leu Gln Glu Ala Thr Cys Lys Ile
                 710                 715                 720

 gca gct cag cag tca gaa act gct cgc ctc acc aca gac gca gca cgt     2446
 Ala Ala Gln Gln Ser Glu Thr Ala Arg Leu Thr Thr Asp Ala Ala Arg
             725                 730                 735

 caa atc tgt gag atg gca gag ttg act aga act cat atc tca gat gct     2494
 Gln Ile Cys Glu Met Ala Glu Leu Thr Arg Thr His Ile Ser Asp Ala
         740                 745                 750

 gtc gtg gct tca gga gct ccc ctt gca ata ctg tat gac cac caa cgg     2542
 Val Val Ala Ser Gly Ala Pro Leu Ala Ile Leu Tyr Asp His Gln Arg
     755                 760                 765

 cag cac ctt cca gac ttt gtg aaa cag ctg agg acc aga act gaa aca     2590
 Gln His Leu Pro Asp Phe Val Lys Gln Leu Arg Thr Arg Thr Glu Thr
 770                 775                 780                 785

 gat agg aaa agt cca tct gtt tca ctc tct cag agt aaa gaa ggg acc     2638
 Asp Arg Lys Ser Pro Ser Val Ser Leu Ser Gln Ser Lys Glu Gly Thr
                 790                 795                 800

 ctt gac tca aag cat cag aag tat tct gct tca tat gat agt tat tct     2686
 Leu Asp Ser Lys His Gln Lys Tyr Ser Ala Ser Tyr Asp Ser Tyr Ser
             805                 810                 815

 gag tct tca gga tac aag aat cat gat aga aga agt agc agt ggt agc     2734
 Glu Ser Ser Gly Tyr Lys Asn His Asp Arg Arg Ser Ser Ser Gly Ser
         820                 825                 830

 agc cgc caa gaa agt cct tca gtt cca tct tgt aag gaa aat gag aag     2782
 Ser Arg Gln Glu Ser Pro Ser Val Pro Ser Cys Lys Glu Asn Glu Lys
     835                 840                 845

 aaa ctt aat ggt gaa aag ata gag agt tcc att gat gaa cag gtt cag     2830
 Lys Leu Asn Gly Glu Lys Ile Glu Ser Ser Ile Asp Glu Gln Val Gln
 850                 855                 860                 865

 act gct gca gat gat tct cta cga agt gat agt gtt cca tct ctt cct     2878
 Thr Ala Ala Asp Asp Ser Leu Arg Ser Asp Ser Val Pro Ser Leu Pro
                 870                 875                 880

 gat gaa aaa gac tca acg tct att gca aca gaa tat tct ctg aaa ttt     2926
 Asp Glu Lys Asp Ser Thr Ser Ile Ala Thr Glu Tyr Ser Leu Lys Phe
             885                 890                 895

 gat gaa tcc atg aca gaa gat gaa ata gaa gaa caa tca ttt cga tca     2974
 Asp Glu Ser Met Thr Glu Asp Glu Ile Glu Glu Gln Ser Phe Arg Ser
         900                 905                 910

 tta cta cct tca gag agt cac cgc aga ttt aac atg gaa aag aga aga     3022
 Leu Leu Pro Ser Glu Ser His Arg Arg Phe Asn Met Glu Lys Arg Arg
     915                 920                 925

 ggt cat cat gat gac tct gat gaa gaa gct tct cca gaa aaa act aca     3070
 Gly His His Asp Asp Ser Asp Glu Glu Ala Ser Pro Glu Lys Thr Thr
 930                 935                 940                 945

 ctg tct act gcc aag gaa ctg aac atg cca ttc tca gga gga caa gat     3118
 Leu Ser Thr Ala Lys Glu Leu Asn Met Pro Phe Ser Gly Gly Gln Asp
                 950                 955                 960

 agc ttt tct aaa ttt act atg gag atg gtt cga cag tat atg aaa gag     3166
 Ser Phe Ser Lys Phe Thr Met Glu Met Val Arg Gln Tyr Met Lys Glu
             965                 970                 975

 gaa gaa atg agg gca gct cac cag tct tca ctc ctg cgt ctc cgt gaa     3214
 Glu Glu Met Arg Ala Ala His Gln Ser Ser Leu Leu Arg Leu Arg Glu
         980                 985                 990

 aag gcc ttg aag gag aag act aag gct gaa ttg gcc tgg tta gag cat     3262
 Lys Ala Leu Lys Glu Lys Thr Lys Ala Glu Leu Ala Trp Leu Glu His
     995                1000                1005

 caa aaa aaa cat cta cga gac aaa gga gag gat gat aaa atg ccc ccg     3310
 Gln Lys Lys His Leu Arg Asp Lys Gly Glu Asp Asp Lys Met Pro Pro
1010                1015                1020                1025

 ctc cgg aag aaa cag cgt ggt ttg ctt tta agg ttg cag caa gaa aag     3358
 Leu Arg Lys Lys Gln Arg Gly Leu Leu Leu Arg Leu Gln Gln Glu Lys
                1030                1035                1040

 gca gaa ata aaa cgt ctt caa gaa gcc aat aag gca gct cgg aag gaa     3406
 Ala Glu Ile Lys Arg Leu Gln Glu Ala Asn Lys Ala Ala Arg Lys Glu
            1045                1050                1055

 aga cag ctg att ctt aaa cag cag gag gag ata gaa aag atc cga cag     3454
 Arg Gln Leu Ile Leu Lys Gln Gln Glu Glu Ile Glu Lys Ile Arg Gln
        1060                1065                1070

 acc acc ata aaa cta cag gag aaa ttg aag tct gca ggg gag agt aaa     3502
 Thr Thr Ile Lys Leu Gln Glu Lys Leu Lys Ser Ala Gly Glu Ser Lys
    1075                1080                1085

 ttg gac tct cat agt gat gat gat aca aag gat aat aag gca acc agt     3550
 Leu Asp Ser His Ser Asp Asp Asp Thr Lys Asp Asn Lys Ala Thr Ser
1090                1095                1100                1105

 cct ggt cca act gac ttg gag acc cgc agt cct tct ccc att tca atc     3598
 Pro Gly Pro Thr Asp Leu Glu Thr Arg Ser Pro Ser Pro Ile Ser Ile
                1110                1115                1120

 tcc agc agt gaa act agc agc att atg cag aaa ctg aag aaa atg aga     3646
 Ser Ser Ser Glu Thr Ser Ser Ile Met Gln Lys Leu Lys Lys Met Arg
            1125                1130                1135

 agc cgc atg gat gaa aag ttt ctg aca aag cgg gag caa aaa tta atg     3694
 Ser Arg Met Asp Glu Lys Phe Leu Thr Lys Arg Glu Gln Lys Leu Met
        1140                1145                1150

 caa cgg cga caa cat gca gag gag ctc cta gag tgg aag cga cgt tta     3742
 Gln Arg Arg Gln His Ala Glu Glu Leu Leu Glu Trp Lys Arg Arg Leu
    1155                1160                1165

 gat gca gaa gaa gca gaa att cgt caa atg gaa aaa caa gct ttg gct     3790
 Asp Ala Glu Glu Ala Glu Ile Arg Gln Met Glu Lys Gln Ala Leu Ala
1170                1175                1180                1185

 gcc tgg gac aaa gaa tta ata aaa ccc aaa act cct aag aaa gaa ctg     3838
 Ala Trp Asp Lys Glu Leu Ile Lys Pro Lys Thr Pro Lys Lys Glu Leu
                1190                1195                1200

 gag gac cag aga aca gaa cag aaa gaa ata gca agt gaa gag gaa tct     3886
 Glu Asp Gln Arg Thr Glu Gln Lys Glu Ile Ala Ser Glu Glu Glu Ser
            1205                1210                1215

 cca gta cct ctg tac tct cat cta aac agt gaa agc tcc att cca gaa     3934
 Pro Val Pro Leu Tyr Ser His Leu Asn Ser Glu Ser Ser Ile Pro Glu
        1220                1225                1230

 gaa tta ggc agc cct gct gtt gaa tat gta cca tcc gag tct ata gga     3982
 Glu Leu Gly Ser Pro Ala Val Glu Tyr Val Pro Ser Glu Ser Ile Gly
    1235                1240                1245

 cag gag cag cca ggg agt cca gat cac agt ata ctt act gaa gaa atg     4030
 Gln Glu Gln Pro Gly Ser Pro Asp His Ser Ile Leu Thr Glu Glu Met
1250                1255                1260                1265

 att tgt tca cag gaa cta gaa tct tct acc tct cct agt aaa cat tca     4078
 Ile Cys Ser Gln Glu Leu Glu Ser Ser Thr Ser Pro Ser Lys His Ser
                1270                1275                1280

 ctt ccc aaa agc tgc aca tct gtg tca aag cag gag tct agc aaa gga     4126
 Leu Pro Lys Ser Cys Thr Ser Val Ser Lys Gln Glu Ser Ser Lys Gly
            1285                1290                1295

 agt cat agg act gga gga caa tgt cac ctg cct atc aag tcc cat cag     4174
 Ser His Arg Thr Gly Gly Gln Cys His Leu Pro Ile Lys Ser His Gln
        1300                1305                1310

 cac tgt tat agt tgg tca gat gag tca tta tct atg aca cag tca gaa     4222
 His Cys Tyr Ser Trp Ser Asp Glu Ser Leu Ser Met Thr Gln Ser Glu
    1315                1320                1325

 act aca tct gac cag agt gat att gaa ggt agg atc aga gct ctg aag     4270
 Thr Thr Ser Asp Gln Ser Asp Ile Glu Gly Arg Ile Arg Ala Leu Lys
1330                1335                1340                1345

 gat gag ttg cgg aaa aga aaa tca gtt gtg aac cag ctg aag aag gaa     4318
 Asp Glu Leu Arg Lys Arg Lys Ser Val Val Asn Gln Leu Lys Lys Glu
                1350                1355                1360

 cag aaa aaa agg caa aag gaa aga ctg aaa gcc caa gaa gcc agt ctg     4366
 Gln Lys Lys Arg Gln Lys Glu Arg Leu Lys Ala Gln Glu Ala Ser Leu
            1365                1370                1375

 atc aag cag tta gag tca tat gat gaa ttt att aag aaa act gaa gcc     4414
 Ile Lys Gln Leu Glu Ser Tyr Asp Glu Phe Ile Lys Lys Thr Glu Ala
        1380                1385                1390

 gag ctt agc caa gat ttg gaa aca tca cca aca gcc aag cct cag att     4462
 Glu Leu Ser Gln Asp Leu Glu Thr Ser Pro Thr Ala Lys Pro Gln Ile
    1395                1400                1405

 aaa acg ctc tcc tca gct tct gaa aaa ccc aag atc aaa ccc ctc aca     4510
 Lys Thr Leu Ser Ser Ala Ser Glu Lys Pro Lys Ile Lys Pro Leu Thr
1410                1415                1420                1425

 cca cta cac aga tct gaa acg gca aag aat tgg aaa tca cta aca gag     4558
 Pro Leu His Arg Ser Glu Thr Ala Lys Asn Trp Lys Ser Leu Thr Glu
                1430                1435                1440

 tca gaa cgt tcc aga gga tcc ctg gag tct att gct gaa cat gtt gat     4606
 Ser Glu Arg Ser Arg Gly Ser Leu Glu Ser Ile Ala Glu His Val Asp
            1445                1450                1455

 gct tca ctg tct ggt tct gag aga tca gta tca gaa agg tct tta tct     4654
 Ala Ser Leu Ser Gly Ser Glu Arg Ser Val Ser Glu Arg Ser Leu Ser
        1460                1465                1470

 gca tat gca aag aga gta aat gaa tgg gac agt cga aca gaa gat ttt     4702
 Ala Tyr Ala Lys Arg Val Asn Glu Trp Asp Ser Arg Thr Glu Asp Phe
    1475                1480                1485

 cag acc cca tct cca gtt ctc aga tca tca agg aaa atc aga gaa gaa     4750
 Gln Thr Pro Ser Pro Val Leu Arg Ser Ser Arg Lys Ile Arg Glu Glu
1490                1495                1500                1505

 tct gga gat tct cta gaa aat gta cct gca tta cat ctt ctc aaa gaa     4798
 Ser Gly Asp Ser Leu Glu Asn Val Pro Ala Leu His Leu Leu Lys Glu
                1510                1515                1520

 tta aat gcc act agt aga att ctt gat atg tca gat ggc aag gtt gga     4846
 Leu Asn Ala Thr Ser Arg Ile Leu Asp Met Ser Asp Gly Lys Val Gly
            1525                1530                1535

 gaa tct agt aaa aaa tca gaa ata aaa gaa ata gag tat aca aaa ttg     4894
 Glu Ser Ser Lys Lys Ser Glu Ile Lys Glu Ile Glu Tyr Thr Lys Leu
        1540                1545                1550

 aag aag agt aag att gaa gat gcc ttt tct aaa gaa ggt aaa tct gat     4942
 Lys Lys Ser Lys Ile Glu Asp Ala Phe Ser Lys Glu Gly Lys Ser Asp
    1555                1560                1565

 gtc tta ctg aaa tta gtc cta gaa cag gga gat tca tct gaa att ctt     4990
 Val Leu Leu Lys Leu Val Leu Glu Gln Gly Asp Ser Ser Glu Ile Leu
1570                1575                1580                1585

 tca aag aaa gat ctt cct tta gat tct gaa aat gtt cag aaa gac cta     5038
 Ser Lys Lys Asp Leu Pro Leu Asp Ser Glu Asn Val Gln Lys Asp Leu
                1590                1595                1600

 gtt gga tta gct att gaa aat ctc cat aaa agt gag gaa atg ttg aaa     5086
 Val Gly Leu Ala Ile Glu Asn Leu His Lys Ser Glu Glu Met Leu Lys
            1605                1610                1615

 gag aga cag tca gat caa gat atg aat cat agt cca aac atc caa tca     5134
 Glu Arg Gln Ser Asp Gln Asp Met Asn His Ser Pro Asn Ile Gln Ser
        1620                1625                1630

 gga aaa gac att cac gaa caa aag aac aca aag gaa aaa gat ttg tct     5182
 Gly Lys Asp Ile His Glu Gln Lys Asn Thr Lys Glu Lys Asp Leu Ser
    1635                1640                1645

 tgg tca gaa cat ctt ttt gct cct aaa gag ata cca tac tct gaa gat     5230
 Trp Ser Glu His Leu Phe Ala Pro Lys Glu Ile Pro Tyr Ser Glu Asp
1650                1655                1660                1665

 ttt gaa gtg tct tct ttc aag aaa gaa att tca gct gaa ttg tac aaa     5278
 Phe Glu Val Ser Ser Phe Lys Lys Glu Ile Ser Ala Glu Leu Tyr Lys
                1670                1675                1680

 gat gat ttt gag gtg tca tct ttg ctg tca ctc agg aaa gac tct cag     5326
 Asp Asp Phe Glu Val Ser Ser Leu Leu Ser Leu Arg Lys Asp Ser Gln
            1685                1690                1695

 tct tgc aga gat aag cca cag cca atg agg agc tct aca agt gga gcc     5374
 Ser Cys Arg Asp Lys Pro Gln Pro Met Arg Ser Ser Thr Ser Gly Ala
        1700                1705                1710

 act agc ttt ggt agt aat gag gaa atc agt gag tgc cta agt gag aaa     5422
 Thr Ser Phe Gly Ser Asn Glu Glu Ile Ser Glu Cys Leu Ser Glu Lys
    1715                1720                1725

 agc ctt tct atc cat agc aat gtt cat tct gac agg ctg ttg gaa ctc     5470
 Ser Leu Ser Ile His Ser Asn Val His Ser Asp Arg Leu Leu Glu Leu
1730                1735                1740                1745

 aag tcc cct act gag ctg atg aaa agt aag gag cgc agt gat gtg gag     5518
 Lys Ser Pro Thr Glu Leu Met Lys Ser Lys Glu Arg Ser Asp Val Glu
                1750                1755                1760

 cat gaa cag caa gtt act gaa tcc cct tcc ttg gct tca gtt cct act     5566
 His Glu Gln Gln Val Thr Glu Ser Pro Ser Leu Ala Ser Val Pro Thr
            1765                1770                1775

 gca gac gag tta ttt gat ttc cac att ggt gat agg gtg ttg att gga     5614
 Ala Asp Glu Leu Phe Asp Phe His Ile Gly Asp Arg Val Leu Ile Gly
        1780                1785                1790

 aat gtt cag cca gga att ctt cga ttc aaa ggt gag act agt ttt gct     5662
 Asn Val Gln Pro Gly Ile Leu Arg Phe Lys Gly Glu Thr Ser Phe Ala
    1795                1800                1805

 aaa gga ttt tgg gcc gga gtg gag tta gat aaa cct gaa gga aat aac     5710
 Lys Gly Phe Trp Ala Gly Val Glu Leu Asp Lys Pro Glu Gly Asn Asn
1810                1815                1820                1825

 aat gga aca tat gat ggt att gca tat ttt gag tgc aaa gaa aag cat     5758
 Asn Gly Thr Tyr Asp Gly Ile Ala Tyr Phe Glu Cys Lys Glu Lys His
                1830                1835                1840

 ggt att ttt gct cct cct caa aaa ata tct cac att cca gaa aac ttt     5806
 Gly Ile Phe Ala Pro Pro Gln Lys Ile Ser His Ile Pro Glu Asn Phe
            1845                1850                1855

 gat gac tat gta gac att aat gaa gat gaa gac tgt tac tca gat gaa     5854
 Asp Asp Tyr Val Asp Ile Asn Glu Asp Glu Asp Cys Tyr Ser Asp Glu
        1860                1865                1870

 cga tat cag tgc tat aat caa gag caa aat gat aca gag ggt cca aaa     5902
 Arg Tyr Gln Cys Tyr Asn Gln Glu Gln Asn Asp Thr Glu Gly Pro Lys
    1875                1880                1885

 gac aga gaa aag gat gtc agt gaa tat ttt tat gag aaa tcc cta cct     5950
 Asp Arg Glu Lys Asp Val Ser Glu Tyr Phe Tyr Glu Lys Ser Leu Pro
1890                1895                1900                1905

 agt gtg aat gat ata gaa gcc tca gtt aat aga agt aga agc ctt aaa     5998
 Ser Val Asn Asp Ile Glu Ala Ser Val Asn Arg Ser Arg Ser Leu Lys
                1910                1915                1920

 ata gaa aca gac aat gta cag gac att tct ggg gta ctt gaa gcc cat     6046
 Ile Glu Thr Asp Asn Val Gln Asp Ile Ser Gly Val Leu Glu Ala His
            1925                1930                1935

 gtt cac cag cag tct tca gtg gat tca cag att tct tca aag gaa aac     6094
 Val His Gln Gln Ser Ser Val Asp Ser Gln Ile Ser Ser Lys Glu Asn
        1940                1945                1950

 aaa gac ctc att tct gat gcc aca gaa aag gtt tcc atc gct gca gaa     6142
 Lys Asp Leu Ile Ser Asp Ala Thr Glu Lys Val Ser Ile Ala Ala Glu
    1955                1960                1965

 gat gac act tta gac aat acc ttt tcc gaa gaa ttg gag aag caa cag     6190
 Asp Asp Thr Leu Asp Asn Thr Phe Ser Glu Glu Leu Glu Lys Gln Gln
1970                1975                1980                1985

 cag ttt aca gaa gag gaa gac aac cta tat gct gaa gct tca gaa aag     6238
 Gln Phe Thr Glu Glu Glu Asp Asn Leu Tyr Ala Glu Ala Ser Glu Lys
                1990                1995                2000

 ctt tgt aca cca ctt ctg gat ctt tta aca aga gaa aaa aac caa ctg     6286
 Leu Cys Thr Pro Leu Leu Asp Leu Leu Thr Arg Glu Lys Asn Gln Leu
            2005                2010                2015

 gaa gcc cag ctg aag tca tca cta aat gag gaa aaa aag tca aaa caa     6334
 Glu Ala Gln Leu Lys Ser Ser Leu Asn Glu Glu Lys Lys Ser Lys Gln
        2020                2025                2030

 caa ctg gaa aaa atc agc tta ctg aca gac agt tta cta aaa gtc ttt     6382
 Gln Leu Glu Lys Ile Ser Leu Leu Thr Asp Ser Leu Leu Lys Val Phe
    2035                2040                2045

 gta aag gac aca gtc aat caa cta caa caa atc aaa aaa acc agg gat     6430
 Val Lys Asp Thr Val Asn Gln Leu Gln Gln Ile Lys Lys Thr Arg Asp
2050                2055                2060                2065

 gag aaa atc cag ctt agc aat cag gag ctt ctt ggt gat gac caa aag     6478
 Glu Lys Ile Gln Leu Ser Asn Gln Glu Leu Leu Gly Asp Asp Gln Lys
                2070                2075                2080

 aaa gta aca ccc caa gac cta tcc caa aat gtt gag gaa cag tcg cca     6526
 Lys Val Thr Pro Gln Asp Leu Ser Gln Asn Val Glu Glu Gln Ser Pro
            2085                2090                2095

 agt att tca ggt tgc ttc tta agt tct gaa ttg gaa gat gaa aaa gaa     6574
 Ser Ile Ser Gly Cys Phe Leu Ser Ser Glu Leu Glu Asp Glu Lys Glu
        2100                2105                2110

 gag att tcc tct cca gat atg tgt ccc aga ccg gag agc cca gta ttt     6622
 Glu Ile Ser Ser Pro Asp Met Cys Pro Arg Pro Glu Ser Pro Val Phe
    2115                2120                2125

 ggt gcc agt ggg cag gaa gaa ctt gct aag aga ctt gct gaa ctt gaa     6670
 Gly Ala Ser Gly Gln Glu Glu Leu Ala Lys Arg Leu Ala Glu Leu Glu
2130                2135                2140                2145

 ctc agc cgg gag ttc ctg agc gcg tta gga gat gat caa gac tgg ttt     6718
 Leu Ser Arg Glu Phe Leu Ser Ala Leu Gly Asp Asp Gln Asp Trp Phe
                2150                2155                2160

 gat gaa gac ttt ggt ttg agc tct tct cac aag atc caa aaa aat aag     6766
 Asp Glu Asp Phe Gly Leu Ser Ser Ser His Lys Ile Gln Lys Asn Lys
            2165                2170                2175

 gca gaa gaa acc att gta cct cta atg gca gaa cct aaa aga gta acc     6814
 Ala Glu Glu Thr Ile Val Pro Leu Met Ala Glu Pro Lys Arg Val Thr
        2180                2185                2190

 caa caa cca tgt gaa aca tta ttg gca gtc ccc cat act gca gaa gaa     6862
 Gln Gln Pro Cys Glu Thr Leu Leu Ala Val Pro His Thr Ala Glu Glu
    2195                2200                2205

 gta gag att ctt gta cat aat gca gca gaa gaa ctt tgg aaa tgg aaa     6910
 Val Glu Ile Leu Val His Asn Ala Ala Glu Glu Leu Trp Lys Trp Lys
2210                2215                2220                2225

 gaa tta ggc cac gat ctt cat agc atc agt att cct aca aaa ctg ctt     6958
 Glu Leu Gly His Asp Leu His Ser Ile Ser Ile Pro Thr Lys Leu Leu
                2230                2235                2240

 ggc tgt gcc agt aaa ggt cta gat ata gaa agc act agt aaa agg gtc     7006
 Gly Cys Ala Ser Lys Gly Leu Asp Ile Glu Ser Thr Ser Lys Arg Val
            2245                2250                2255

 tac aaa cag gcg gtt ttt gat tta aca aaa gag att ttt gag gaa ata     7054
 Tyr Lys Gln Ala Val Phe Asp Leu Thr Lys Glu Ile Phe Glu Glu Ile
        2260                2265                2270

 ttt gct gag gat ccc aac tta aat caa cct gtc tgg atg aag cca tgt     7102
 Phe Ala Glu Asp Pro Asn Leu Asn Gln Pro Val Trp Met Lys Pro Cys
    2275                2280                2285

 aga atc aac tct agt tat ttc cga cga gtg aaa aat cca aat aac ctt     7150
 Arg Ile Asn Ser Ser Tyr Phe Arg Arg Val Lys Asn Pro Asn Asn Leu
2290                2295                2300                2305

 gat gaa atc aag agc ttc ata gca agt gaa gta ctc aag ttg ttc agt     7198
 Asp Glu Ile Lys Ser Phe Ile Ala Ser Glu Val Leu Lys Leu Phe Ser
                2310                2315                2320

 ctt aaa aag gag cca aac cac aaa aca gat tgg cag aaa atg atg aaa     7246
 Leu Lys Lys Glu Pro Asn His Lys Thr Asp Trp Gln Lys Met Met Lys
            2325                2330                2335

 ttt gga aga aag aaa aga gac cga gtg gat cat atc ctg gtt cag gag     7294
 Phe Gly Arg Lys Lys Arg Asp Arg Val Asp His Ile Leu Val Gln Glu
        2340                2345                2350

 ctc cat gag gag gag gca cag tgg gtg aac tat gat gag gat gag ttg     7342
 Leu His Glu Glu Glu Ala Gln Trp Val Asn Tyr Asp Glu Asp Glu Leu
    2355                2360                2365

 tgt gtg aaa atg cag cta gcc gac ggg atc ttt gag acc ctg atc aaa     7390
 Cys Val Lys Met Gln Leu Ala Asp Gly Ile Phe Glu Thr Leu Ile Lys
2370                2375                2380                2385

 gat act att gat gtt ctg aat cag atc agt gaa aag cag ggg aga atg     7438
 Asp Thr Ile Asp Val Leu Asn Gln Ile Ser Glu Lys Gln Gly Arg Met
                2390                2395                2400

 cta ctt gtg tga cat cttgcaaata aatcgaacgc tgagtgctaa tgtgagtcct     7493
 Leu Leu Val 






      <210> 300
      <211> 6834
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (925)..(6834)

      <400> 300
 atgggtagac aaggtggcga acgattcaac caggctctgg gcttggcgca tggtgggcgg     60

 tggcgcccac acctgggcct gggaacccgc cgctcgggca tcactggctg ccgcggcgac    120

 cggcgaggac acatgaccga ggagcgaaag tgcctgaggc agctctggct cggagagcct    180

 tttgctagcc ccacggggac ctctgtgcac ggatggaccc gcccggacct ggcgggaagc    240

 ggcctggcag gcggcggccc cggcggcatc agcagagaca ggacggggcc gacgccgcgg    300

 gcccctgagg cctttggggc ctactgtcat ctggtacgca gcagcattct gagggctctc    360

 ttcaccccca tctccattcc gaaggaccat gttcacatct ttcagtaccc cctgagaaag    420

 aatgtctggg aaaatttgaa tgaatatgtt gaagcattaa ttaccttgaa acaaaaaatt    480

 atcaatacag aagagaatag taatctgcat caccaagtgg aagagatgct tcaaaaaatt    540

 tctcctctac agaaatgtca ggaagaactg ggatctttaa aagcagagct agaagagaaa    600

 aagagttctt taaagttgta tcaggatact catcaggaat atgctcgtgt aaaggaagaa    660

 tgcttgaaga gtgatgctca gaagaagaaa ctagaagcta aggtgaagaa gctgcaagga    720

 aaagtgaaac tgcttctgaa ggaactctgg ctctgtgtaa acacaacaca cagactacct    780

 ggtgaaggca gcaggtgtgt cccagaaaaa cctgccaaag caatcaccag ctccagagtg    840

 cctggggaag atggtacgct acctccaaca cagggcagcc ctctcaggac ctcaaatgtg    900

 cagacatgcc tcacaaaact gtcc   atg gag ata aag gag gac ttt tta tgt     951
                              Met Glu Ile Lys Glu Asp Phe Leu Cys
                                1               5

 caa aat gtg gaa aaa cag agc tcc agt gga aca aat tgt agt tct gac      999
 Gln Asn Val Glu Lys Gln Ser Ser Ser Gly Thr Asn Cys Ser Ser Asp
  10                  15                  20                  25

 cat gtt ttt aat gag aat gga aat ctt gag gtt tta gta caa agt cat     1047
 His Val Phe Asn Glu Asn Gly Asn Leu Glu Val Leu Val Gln Ser His
                  30                  35                  40

 cgt gac ggt ggt agt act gaa ttt gtt gat cat gat cat ttt ttt gat     1095
 Arg Asp Gly Gly Ser Thr Glu Phe Val Asp His Asp His Phe Phe Asp
              45                  50                  55

 gaa gat ctt caa gct gca att gac ttc ttc aaa ctt ccc cct cct ctt     1143
 Glu Asp Leu Gln Ala Ala Ile Asp Phe Phe Lys Leu Pro Pro Pro Leu
          60                  65                  70

 ctg tca cca gtg ccc tcg ccc cct ccg atg tca tca cct cac ccg ggt     1191
 Leu Ser Pro Val Pro Ser Pro Pro Pro Met Ser Ser Pro His Pro Gly
      75                  80                  85

 tcc tta ccg tct tca ttt gca cct gaa acc tac ttt gga gaa tat aca     1239
 Ser Leu Pro Ser Ser Phe Ala Pro Glu Thr Tyr Phe Gly Glu Tyr Thr
  90                  95                 100                 105

 gat tcc agc gat aat gac tca gtc cag ctt aga aat tct gct gag tct     1287
 Asp Ser Ser Asp Asn Asp Ser Val Gln Leu Arg Asn Ser Ala Glu Ser
                 110                 115                 120

 gtt tca gaa gat gat aca act gaa tca cag aat tat ttt ggc tca ttg     1335
 Val Ser Glu Asp Asp Thr Thr Glu Ser Gln Asn Tyr Phe Gly Ser Leu
             125                 130                 135

 aga aaa aat aaa gga agt ggc aca tgg gag gaa aag ccc aaa tca cat     1383
 Arg Lys Asn Lys Gly Ser Gly Thr Trp Glu Glu Lys Pro Lys Ser His
         140                 145                 150

 gaa gct atc caa gct ctg aat aca tgg gaa gta aat aaa gtg aca act     1431
 Glu Ala Ile Gln Ala Leu Asn Thr Trp Glu Val Asn Lys Val Thr Thr
     155                 160                 165

 tct gga ctc gag act ttc aca gca aca ctg aga gaa tct tct gcc aca     1479
 Ser Gly Leu Glu Thr Phe Thr Ala Thr Leu Arg Glu Ser Ser Ala Thr
 170                 175                 180                 185

 cac tcc tta gtt ggt gaa aaa cac tgg acc aca gca tct cga tcc atg     1527
 His Ser Leu Val Gly Glu Lys His Trp Thr Thr Ala Ser Arg Ser Met
                 190                 195                 200

 agt gat aga aaa aga gac att tta cat gag aca aaa aca caa atg gag     1575
 Ser Asp Arg Lys Arg Asp Ile Leu His Glu Thr Lys Thr Gln Met Glu
             205                 210                 215

 gtt agg gag atg gat aag tca gta caa act gag aag acc att cat aaa     1623
 Val Arg Glu Met Asp Lys Ser Val Gln Thr Glu Lys Thr Ile His Lys
         220                 225                 230

 ctc act cga ggt cta tgc att gag aga ttg tct gcc agc cct gca caa     1671
 Leu Thr Arg Gly Leu Cys Ile Glu Arg Leu Ser Ala Ser Pro Ala Gln
     235                 240                 245

 gag aag gaa gct gcc cct ggg aag tct gag ttg tgt tct tct ccc ctt     1719
 Glu Lys Glu Ala Ala Pro Gly Lys Ser Glu Leu Cys Ser Ser Pro Leu
 250                 255                 260                 265

 ggc aaa agg cca tta aat gaa ctc atg gaa tct gaa gga aaa acc gta     1767
 Gly Lys Arg Pro Leu Asn Glu Leu Met Glu Ser Glu Gly Lys Thr Val
                 270                 275                 280

 ttg tct aaa atg atg gga tcg ccc aaa tca gag ttt act aag tgg aca     1815
 Leu Ser Lys Met Met Gly Ser Pro Lys Ser Glu Phe Thr Lys Trp Thr
             285                 290                 295

 cga att aat gaa atc act tct gaa cca gac cgt atc aca gtt tct ggc     1863
 Arg Ile Asn Glu Ile Thr Ser Glu Pro Asp Arg Ile Thr Val Ser Gly
         300                 305                 310

 cat ttt cac aga cta tct aga gaa ttg gaa aag gaa aaa gaa gat act     1911
 His Phe His Arg Leu Ser Arg Glu Leu Glu Lys Glu Lys Glu Asp Thr
     315                 320                 325

 caa ggg ttc act tta gga gaa tca cct gaa tca gaa gat gat gac tca     1959
 Gln Gly Phe Thr Leu Gly Glu Ser Pro Glu Ser Glu Asp Asp Asp Ser
 330                 335                 340                 345

 ggt gat gga atg gat gta gca ggg ctt gac att gaa acc agt ttt tct     2007
 Gly Asp Gly Met Asp Val Ala Gly Leu Asp Ile Glu Thr Ser Phe Ser
                 350                 355                 360

 tcc tct tct acc ttg gta gca ttg tct gtt ggc agt aat ccc cag tct     2055
 Ser Ser Ser Thr Leu Val Ala Leu Ser Val Gly Ser Asn Pro Gln Ser
             365                 370                 375

 tct tct ggg tta gac tgt ggt aat gat aca gat att act act aaa gta     2103
 Ser Ser Gly Leu Asp Cys Gly Asn Asp Thr Asp Ile Thr Thr Lys Val
         380                 385                 390

 ttc tct act gaa ccg cat cat tca gaa cat aaa ttg caa act aaa act     2151
 Phe Ser Thr Glu Pro His His Ser Glu His Lys Leu Gln Thr Lys Thr
     395                 400                 405

 tta aac aca tta cat ctg cag tct gag cca ccg gag tgt tct ata gga     2199
 Leu Asn Thr Leu His Leu Gln Ser Glu Pro Pro Glu Cys Ser Ile Gly
 410                 415                 420                 425

 gga aac aac ttg gag aat agc ttg tgt gcc ttg agc cct gaa ttg gga     2247
 Gly Asn Asn Leu Glu Asn Ser Leu Cys Ala Leu Ser Pro Glu Leu Gly
                 430                 435                 440

 gca tct aat ttt aat gat cag aag agc agt ggg ata gaa tat aca aaa     2295
 Ala Ser Asn Phe Asn Asp Gln Lys Ser Ser Gly Ile Glu Tyr Thr Lys
             445                 450                 455

 gta gta aaa ggc ttg acc aaa ata cat tca ctt cct cgg tca gta ttt     2343
 Val Val Lys Gly Leu Thr Lys Ile His Ser Leu Pro Arg Ser Val Phe
         460                 465                 470

 atg aaa gct aca aaa gat ggg caa tgt gaa agt caa gat cca aga att     2391
 Met Lys Ala Thr Lys Asp Gly Gln Cys Glu Ser Gln Asp Pro Arg Ile
     475                 480                 485

 gag ctc aca cta aat aag cca gat ttc aca tca tta ata ggt tct cag     2439
 Glu Leu Thr Leu Asn Lys Pro Asp Phe Thr Ser Leu Ile Gly Ser Gln
 490                 495                 500                 505

 gct gcc ttg atc aag agt ggt ttg ggt ttt gtt aaa agt act tca tgg     2487
 Ala Ala Leu Ile Lys Ser Gly Leu Gly Phe Val Lys Ser Thr Ser Trp
                 510                 515                 520

 cac cat agt gat tta tta agg aaa ggt ggc gaa gaa agt ctg aga gcc     2535
 His His Ser Asp Leu Leu Arg Lys Gly Gly Glu Glu Ser Leu Arg Ala
             525                 530                 535

 aaa tca gaa cat gaa cag aag act agc cat cag tta caa aag gca atg     2583
 Lys Ser Glu His Glu Gln Lys Thr Ser His Gln Leu Gln Lys Ala Met
         540                 545                 550

 cca ttc cta caa aat aga gga cca aca ccc aag cct gat ctt ctt aga     2631
 Pro Phe Leu Gln Asn Arg Gly Pro Thr Pro Lys Pro Asp Leu Leu Arg
     555                 560                 565

 gaa aat aac aat cct gta gaa ttc aag acc act gca tcg gtg ttg cct     2679
 Glu Asn Asn Asn Pro Val Glu Phe Lys Thr Thr Ala Ser Val Leu Pro
 570                 575                 580                 585

 aat caa gta tca gtt atc aca aaa cag aca aga cct gaa aag gtt cag     2727
 Asn Gln Val Ser Val Ile Thr Lys Gln Thr Arg Pro Glu Lys Val Gln
                 590                 595                 600

 agt gcc aaa ttg gaa cac ttg agg cca cat agg gtt gag cct acc tta     2775
 Ser Ala Lys Leu Glu His Leu Arg Pro His Arg Val Glu Pro Thr Leu
             605                 610                 615

 gta aca gaa aat agt ggc aac aaa acc ggt atg tca act ata gca aaa     2823
 Val Thr Glu Asn Ser Gly Asn Lys Thr Gly Met Ser Thr Ile Ala Lys
         620                 625                 630

 tgt gat ggg gaa aga gat gat aca aca caa aac atc acg gag gtg gct     2871
 Cys Asp Gly Glu Arg Asp Asp Thr Thr Gln Asn Ile Thr Glu Val Ala
     635                 640                 645

 gct gtg aaa agc att tca cca gaa gtt tct gcc tct agg aga aaa tta     2919
 Ala Val Lys Ser Ile Ser Pro Glu Val Ser Ala Ser Arg Arg Lys Leu
 650                 655                 660                 665

 gat ttt aat tct cca ggt ggt tct tca cca gta gaa aat tct gat tgt     2967
 Asp Phe Asn Ser Pro Gly Gly Ser Ser Pro Val Glu Asn Ser Asp Cys
                 670                 675                 680

 tcc aca aat agc aga tta tct ttc tct cct gaa aat atc ctc atc caa     3015
 Ser Thr Asn Ser Arg Leu Ser Phe Ser Pro Glu Asn Ile Leu Ile Gln
             685                 690                 695

 aac caa gac att gtg aga gaa gct gca gtg cag gga gat ggg cag aag     3063
 Asn Gln Asp Ile Val Arg Glu Ala Ala Val Gln Gly Asp Gly Gln Lys
         700                 705                 710

 caa agg cag cct cag gcc aca gat ctg gac tcc agt ggg aca cat ggc     3111
 Gln Arg Gln Pro Gln Ala Thr Asp Leu Asp Ser Ser Gly Thr His Gly
     715                 720                 725

 agt gag atg ctt cca gcc aca gaa gtg act gtg tca gga ggg ttt tct     3159
 Ser Glu Met Leu Pro Ala Thr Glu Val Thr Val Ser Gly Gly Phe Ser
 730                 735                 740                 745

 gtt gaa gaa acc agc tgt gga gac aca ggg aga tct ggt ggt gag gcc     3207
 Val Glu Glu Thr Ser Cys Gly Asp Thr Gly Arg Ser Gly Gly Glu Ala
                 750                 755                 760

 ctg gct gtt gca aat gat tct acc agc aca cca caa aat gct aat gga     3255
 Leu Ala Val Ala Asn Asp Ser Thr Ser Thr Pro Gln Asn Ala Asn Gly
             765                 770                 775

 ctt tgg aaa ttg aaa tct aca act ccc ggt ggt gct ttg cct gag tgt     3303
 Leu Trp Lys Leu Lys Ser Thr Thr Pro Gly Gly Ala Leu Pro Glu Cys
         780                 785                 790

 ttt ggc acc aca gac act act ttt tct tca gca ttt tgc aga aaa cat     3351
 Phe Gly Thr Thr Asp Thr Thr Phe Ser Ser Ala Phe Cys Arg Lys His
     795                 800                 805

 gga gag aca cag gat acc tcc caa agt agc ctg cct ggt acc tta cat     3399
 Gly Glu Thr Gln Asp Thr Ser Gln Ser Ser Leu Pro Gly Thr Leu His
 810                 815                 820                 825

 tgt tac aca ggc att cga gag ggg gga gac gac act gag gta gag agt     3447
 Cys Tyr Thr Gly Ile Arg Glu Gly Gly Asp Asp Thr Glu Val Glu Ser
                 830                 835                 840

 gag gca ttt agc tgc agt gag ggg agc gaa cag caa gat gct cct gat     3495
 Glu Ala Phe Ser Cys Ser Glu Gly Ser Glu Gln Gln Asp Ala Pro Asp
             845                 850                 855

 gac tca cag aaa aat tta gga gac aca gat gct gct gta gcc gag gtg     3543
 Asp Ser Gln Lys Asn Leu Gly Asp Thr Asp Ala Ala Val Ala Glu Val
         860                 865                 870

 aga cct tcc tta gag gta ggt tat ttg acg tca gct ctg caa gat ttt     3591
 Arg Pro Ser Leu Glu Val Gly Tyr Leu Thr Ser Ala Leu Gln Asp Phe
     875                 880                 885

 aac ata agt act ttt tct gag ctg gat aga ctt tcc aca tca gag gtt     3639
 Asn Ile Ser Thr Phe Ser Glu Leu Asp Arg Leu Ser Thr Ser Glu Val
 890                 895                 900                 905

 gtg atg ttt ctt gag agc tgt cag tta ggg gat tat agt tca ggg gac     3687
 Val Met Phe Leu Glu Ser Cys Gln Leu Gly Asp Tyr Ser Ser Gly Asp
                 910                 915                 920

 tct gtt tct gaa tgt tct agt aaa gga acc cta agt aaa gaa atg aac     3735
 Ser Val Ser Glu Cys Ser Ser Lys Gly Thr Leu Ser Lys Glu Met Asn
             925                 930                 935

 aaa gaa tta aag gca agt gaa ata gga gaa aaa tac aga aag caa ccc     3783
 Lys Glu Leu Lys Ala Ser Glu Ile Gly Glu Lys Tyr Arg Lys Gln Pro
         940                 945                 950

 tgt gag gaa gaa aca ctt gga acc tgt gaa gag tgg att gaa tca gag     3831
 Cys Glu Glu Glu Thr Leu Gly Thr Cys Glu Glu Trp Ile Glu Ser Glu
     955                 960                 965

 gaa gat gat tat tcg tta aaa aat aca agt cag ctc act cag tgt tct     3879
 Glu Asp Asp Tyr Ser Leu Lys Asn Thr Ser Gln Leu Thr Gln Cys Ser
 970                 975                 980                 985

 ttg gaa act ctg tct gag gtt ctg acc aag att agg caa gaa ctt caa     3927
 Leu Glu Thr Leu Ser Glu Val Leu Thr Lys Ile Arg Gln Glu Leu Gln
                 990                 995                1000

 aca aat tct gaa gat tgc aat ggt aaa gat act ggc agt tta ttg ctc     3975
 Thr Asn Ser Glu Asp Cys Asn Gly Lys Asp Thr Gly Ser Leu Leu Leu
            1005                1010                1015

 tta aat aac caa ccc cac aag cag ctg ccc ttg gac act gag ggc agc     4023
 Leu Asn Asn Gln Pro His Lys Gln Leu Pro Leu Asp Thr Glu Gly Ser
        1020                1025                1030

 tct ccc atc agc ggt atg cct cag aat gaa aac cct cag agc aga cca     4071
 Ser Pro Ile Ser Gly Met Pro Gln Asn Glu Asn Pro Gln Ser Arg Pro
    1035                1040                1045

 gag gcc cgt tca gat gca ggc agg caa acc gat ggt ggg gaa gaa gac     4119
 Glu Ala Arg Ser Asp Ala Gly Arg Gln Thr Asp Gly Gly Glu Glu Asp
1050                1055                1060                1065

 ctg cca gaa cct gtg gag cca tca gcc ttg tgc tct gac tct gtg atg     4167
 Leu Pro Glu Pro Val Glu Pro Ser Ala Leu Cys Ser Asp Ser Val Met
                1070                1075                1080

 gag cca tcc ata gag caa agt tct aac tgc gag gcc gaa aca aca ttt     4215
 Glu Pro Ser Ile Glu Gln Ser Ser Asn Cys Glu Ala Glu Thr Thr Phe
            1085                1090                1095

 cag tgt cag ata gca aca gtg acc tca gaa gtt ata aac gta ctt ata     4263
 Gln Cys Gln Ile Ala Thr Val Thr Ser Glu Val Ile Asn Val Leu Ile
        1100                1105                1110

 aat aag gat cag aat cta gtc att gaa aag ggg gac aac tgg aca atc     4311
 Asn Lys Asp Gln Asn Leu Val Ile Glu Lys Gly Asp Asn Trp Thr Ile
    1115                1120                1125

 atc agt ggt gta gct gtc ttg cca cat gtg gac cag gtc aca ctg tgt     4359
 Ile Ser Gly Val Ala Val Leu Pro His Val Asp Gln Val Thr Leu Cys
1130                1135                1140                1145

 gac att cct gga gac atc cct att tct cag gat caa gga gag ctg gaa     4407
 Asp Ile Pro Gly Asp Ile Pro Ile Ser Gln Asp Gln Gly Glu Leu Glu
                1150                1155                1160

 gct ggt tgc atc cca gtg act tct gct gag aag tcc cca gag gcc agt     4455
 Ala Gly Cys Ile Pro Val Thr Ser Ala Glu Lys Ser Pro Glu Ala Ser
            1165                1170                1175

 cac act ggc cct gca ttt cag gag gct cca tgt ggc aat aat ctt tca     4503
 His Thr Gly Pro Ala Phe Gln Glu Ala Pro Cys Gly Asn Asn Leu Ser
        1180                1185                1190

 tgt ccc caa gag gat gtt tca agc agt ggt cag agc acc aac ttt gat     4551
 Cys Pro Gln Glu Asp Val Ser Ser Ser Gly Gln Ser Thr Asn Phe Asp
    1195                1200                1205

 aag agt cgt ttg cga aat aga ccc gtt aag cct agt ata tgg att agt     4599
 Lys Ser Arg Leu Arg Asn Arg Pro Val Lys Pro Ser Ile Trp Ile Ser
1210                1215                1220                1225

 tct caa atc tat gat caa aac ttc gag act cag att gtt gcg tct gat     4647
 Ser Gln Ile Tyr Asp Gln Asn Phe Glu Thr Gln Ile Val Ala Ser Asp
                1230                1235                1240

 cac aca tat tat aac tca aaa cta gag cca tct ggc aaa aat aag aat     4695
 His Thr Tyr Tyr Asn Ser Lys Leu Glu Pro Ser Gly Lys Asn Lys Asn
            1245                1250                1255

 cga tca aag att tca aac aaa gat cag tca aac aaa cca gta aaa act     4743
 Arg Ser Lys Ile Ser Asn Lys Asp Gln Ser Asn Lys Pro Val Lys Thr
        1260                1265                1270

 tca gcg tcg agc aga gtt gaa act cat cag agt gaa gtt gct cag tca     4791
 Ser Ala Ser Ser Arg Val Glu Thr His Gln Ser Glu Val Ala Gln Ser
    1275                1280                1285

 ttt tca ggg gaa aaa gct aat aca aaa act caa aga agc caa act cag     4839
 Phe Ser Gly Glu Lys Ala Asn Thr Lys Thr Gln Arg Ser Gln Thr Gln
1290                1295                1300                1305

 acc att tta gca aat gct gat aca tcc act cct aca gat tgt tct cct     4887
 Thr Ile Leu Ala Asn Ala Asp Thr Ser Thr Pro Thr Asp Cys Ser Pro
                1310                1315                1320

 gac aca ctg agt aaa ata cgg caa gag gtg ggg cct cct ttg ccg cct     4935
 Asp Thr Leu Ser Lys Ile Arg Gln Glu Val Gly Pro Pro Leu Pro Pro
            1325                1330                1335

 ctg ctt gct cct ctg ata gct aca cct cca agg act tca cag cca ctg     4983
 Leu Leu Ala Pro Leu Ile Ala Thr Pro Pro Arg Thr Ser Gln Pro Leu
        1340                1345                1350

 tct cca ctg ata tcg agt tct agt cct tcc tca cca gcc tct cct gtt     5031
 Ser Pro Leu Ile Ser Ser Ser Ser Pro Ser Ser Pro Ala Ser Pro Val
    1355                1360                1365

 ggc cag gtt tct ccc ttc cgt gaa acc cca gtg cct cct gcc atg tct     5079
 Gly Gln Val Ser Pro Phe Arg Glu Thr Pro Val Pro Pro Ala Met Ser
1370                1375                1380                1385

 cca tgg cca gag gac ccc aga cgt gcc tct cct cca gat cct tct cca     5127
 Pro Trp Pro Glu Asp Pro Arg Arg Ala Ser Pro Pro Asp Pro Ser Pro
                1390                1395                1400

 tct cca tct gca gct tca gcc agt gag agg gta gtg ccg tct cct ctg     5175
 Ser Pro Ser Ala Ala Ser Ala Ser Glu Arg Val Val Pro Ser Pro Leu
            1405                1410                1415

 cag ttc tgt gcg gcc acg ccg aag cac gca ctt cct gtg cct ggc cga     5223
 Gln Phe Cys Ala Ala Thr Pro Lys His Ala Leu Pro Val Pro Gly Arg
        1420                1425                1430

 ctc cca ccc tgt gca tct ggc cac gct gct gtg gga ggg cct cag gag     5271
 Leu Pro Pro Cys Ala Ser Gly His Ala Ala Val Gly Gly Pro Gln Glu
    1435                1440                1445

 aat tct gtg aaa atc ctt gac acc atg tat cca gag tta tct gcc agg     5319
 Asn Ser Val Lys Ile Leu Asp Thr Met Tyr Pro Glu Leu Ser Ala Arg
1450                1455                1460                1465

 gcc cgg acc ctc aac atc ctc aaa ggg aat att caa ctc aca cga ggt     5367
 Ala Arg Thr Leu Asn Ile Leu Lys Gly Asn Ile Gln Leu Thr Arg Gly
                1470                1475                1480

 ccg cct gct gac tgt aag aat tta ccg gga cct gcc agt gct atg ata     5415
 Pro Pro Ala Asp Cys Lys Asn Leu Pro Gly Pro Ala Ser Ala Met Ile
            1485                1490                1495

 gga ttc aaa acg atc act tca gca gca act gct ttt gtc aaa act ggg     5463
 Gly Phe Lys Thr Ile Thr Ser Ala Ala Thr Ala Phe Val Lys Thr Gly
        1500                1505                1510

 agc agc tct ggt ggt gac tgt aac caa gac aag tca aga gat ttg ggg     5511
 Ser Ser Ser Gly Gly Asp Cys Asn Gln Asp Lys Ser Arg Asp Leu Gly
    1515                1520                1525

 act cag cag gat tca agc ggg aaa aga aca ctg tca acg tct aca ctg     5559
 Thr Gln Gln Asp Ser Ser Gly Lys Arg Thr Leu Ser Thr Ser Thr Leu
1530                1535                1540                1545

 aga agt gct aaa aga ctg cgc ctg gac act ggg tcc cca gaa cca gaa     5607
 Arg Ser Ala Lys Arg Leu Arg Leu Asp Thr Gly Ser Pro Glu Pro Glu
                1550                1555                1560

 acc agg gga gtc act gca gaa gga atc cac aaa aac ctc cca ggg aac     5655
 Thr Arg Gly Val Thr Ala Glu Gly Ile His Lys Asn Leu Pro Gly Asn
            1565                1570                1575

 ctc cct cca gct gaa gtt gca aca aca aat gag gaa aga agt tgt tct     5703
 Leu Pro Pro Ala Glu Val Ala Thr Thr Asn Glu Glu Arg Ser Cys Ser
        1580                1585                1590

 agt cca gcc gtc agt gca gtt tca cag ttg cct tta agc cca aaa gaa     5751
 Ser Pro Ala Val Ser Ala Val Ser Gln Leu Pro Leu Ser Pro Lys Glu
    1595                1600                1605

 act gtg gag tcc cat gat aaa gcc ata gct aat gcc ctg aag aaa att     5799
 Thr Val Glu Ser His Asp Lys Ala Ile Ala Asn Ala Leu Lys Lys Ile
1610                1615                1620                1625

 gca gag ttt tct ttt gat ctg tta cct gtc att cgt agt cat gtg tat     5847
 Ala Glu Phe Ser Phe Asp Leu Leu Pro Val Ile Arg Ser His Val Tyr
                1630                1635                1640

 gtg gga aat atc tcc aaa aag ccc gta atg aga gat caa gag aag gaa     5895
 Val Gly Asn Ile Ser Lys Lys Pro Val Met Arg Asp Gln Glu Lys Glu
            1645                1650                1655

 gtt gtt tat gaa ttt agc aca aca aaa aag cat tta gca gag tgc ttg     5943
 Val Val Tyr Glu Phe Ser Thr Thr Lys Lys His Leu Ala Glu Cys Leu
        1660                1665                1670

 ctt cac tct att ctc tca gaa cta aaa att cag aag ata tct atg gac     5991
 Leu His Ser Ile Leu Ser Glu Leu Lys Ile Gln Lys Ile Ser Met Asp
    1675                1680                1685

 cac aat tac att cac gcc ctc tgc agg gtg tat gtg ggt att tgt cgg     6039
 His Asn Tyr Ile His Ala Leu Cys Arg Val Tyr Val Gly Ile Cys Arg
1690                1695                1700                1705

 caa ctc gga gac ttg gaa aga gct cgt ttg ttt tgc tac agc cta ctt     6087
 Gln Leu Gly Asp Leu Glu Arg Ala Arg Leu Phe Cys Tyr Ser Leu Leu
                1710                1715                1720

 aaa gaa gat ttt ccg gag tct gaa aaa tta act ttg ttt att gca aac     6135
 Lys Glu Asp Phe Pro Glu Ser Glu Lys Leu Thr Leu Phe Ile Ala Asn
            1725                1730                1735

 atg tgg cat gat ata ttt ctc tct caa tcg gtg att aat aaa gca atg     6183
 Met Trp His Asp Ile Phe Leu Ser Gln Ser Val Ile Asn Lys Ala Met
        1740                1745                1750

 cag tta gtt gcc agg caa cgt gct aaa gga gag gtt ctg aac tgc ttg     6231
 Gln Leu Val Ala Arg Gln Arg Ala Lys Gly Glu Val Leu Asn Cys Leu
    1755                1760                1765

 aga gct ttt ctt aat tgg gaa aag aat gcc ccg gta gat gtt ggc ttc     6279
 Arg Ala Phe Leu Asn Trp Glu Lys Asn Ala Pro Val Asp Val Gly Phe
1770                1775                1780                1785

 atg gtt tct aag ctg ctt ttg acc ata cag tta tgt cca aaa aca gaa     6327
 Met Val Ser Lys Leu Leu Leu Thr Ile Gln Leu Cys Pro Lys Thr Glu
                1790                1795                1800

 ttt caa cct agt gaa aaa ttt ggt gaa gac cta agt gat aac act tgg     6375
 Phe Gln Pro Ser Glu Lys Phe Gly Glu Asp Leu Ser Asp Asn Thr Trp
            1805                1810                1815

 gaa tac ata ttt gcc att gat ctg ctc tgc tgc cat cag aaa tgg atc     6423
 Glu Tyr Ile Phe Ala Ile Asp Leu Leu Cys Cys His Gln Lys Trp Ile
        1820                1825                1830

 tgg acg cat gat aac atc ata agt aag gag ctg tgg cct gtg atg gat     6471
 Trp Thr His Asp Asn Ile Ile Ser Lys Glu Leu Trp Pro Val Met Asp
    1835                1840                1845

 aaa tgg ata aaa tac aga aaa gga cat gca aac att gcg tat act cct     6519
 Lys Trp Ile Lys Tyr Arg Lys Gly His Ala Asn Ile Ala Tyr Thr Pro
1850                1855                1860                1865

 gat att att ata gcc tca ata ctg agg ctg att ggt cgt tta ggc caa     6567
 Asp Ile Ile Ile Ala Ser Ile Leu Arg Leu Ile Gly Arg Leu Gly Gln
                1870                1875                1880

 ttg ggt ttg aaa gaa gga ttt cca tct gct gtg aaa aat att agt tcg     6615
 Leu Gly Leu Lys Glu Gly Phe Pro Ser Ala Val Lys Asn Ile Ser Ser
            1885                1890                1895

 gtt att ggt atg ttt ata cag cat gct cac gat gaa gat ata cca tgg     6663
 Val Ile Gly Met Phe Ile Gln His Ala His Asp Glu Asp Ile Pro Trp
        1900                1905                1910

 ggt ata cag tta gca gcc gtg tat gct ctt tgt gac ttg agt ccc agc     6711
 Gly Ile Gln Leu Ala Ala Val Tyr Ala Leu Cys Asp Leu Ser Pro Ser
    1915                1920                1925

 aat cca gca gaa att tcc aag atc ctg gaa gct tgg cgg aga gag gcc     6759
 Asn Pro Ala Glu Ile Ser Lys Ile Leu Glu Ala Trp Arg Arg Glu Ala
1930                1935                1940                1945

 tcc aaa agc gtt ccg tct gcg att gtc agc tgc cta gag gaa gtc agt     6807
 Ser Lys Ser Val Pro Ser Ala Ile Val Ser Cys Leu Glu Glu Val Ser
                1950                1955                1960

 gcc ctg agc aca gag gag ctt ggc tga                                 6834
 Ala Leu Ser Thr Glu Glu Leu Gly 
            1965





      <210> 301
      <211> 2388
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (9)..(863)

      <400> 301
 agatcatc atg gtg gca cca aag agt cac aca gat gac tgg gct cct ggg      50
          Met Val Ala Pro Lys Ser His Thr Asp Asp Trp Ala Pro Gly
            1               5                  10

 cct ttc tcc agt aag cca cag agg agt cag ctg caa ata ttc tct tct       98
 Pro Phe Ser Ser Lys Pro Gln Arg Ser Gln Leu Gln Ile Phe Ser Ser
  15                  20                  25                  30

 gtt cta cag acc tct ctc ctc ttc ctg ctc atg gga cta aga gcc tct      146
 Val Leu Gln Thr Ser Leu Leu Phe Leu Leu Met Gly Leu Arg Ala Ser
                  35                  40                  45

 gga aag gac tca gcc cca aca gtg gtg tca ggg atc cta ggg ggt tcc      194
 Gly Lys Asp Ser Ala Pro Thr Val Val Ser Gly Ile Leu Gly Gly Ser
              50                  55                  60

 gtg act ctc ccc cta aac atc tca gta gac aca gag att gag aac gtc      242
 Val Thr Leu Pro Leu Asn Ile Ser Val Asp Thr Glu Ile Glu Asn Val
          65                  70                  75

 atc tgg att ggt ccc aaa aat gct ctt gct ttc gca cgt ccc aaa gaa      290
 Ile Trp Ile Gly Pro Lys Asn Ala Leu Ala Phe Ala Arg Pro Lys Glu
      80                  85                  90

 aat gta acc att atg gtc aaa agc tac ctg ggc cga cta gac atc acc      338
 Asn Val Thr Ile Met Val Lys Ser Tyr Leu Gly Arg Leu Asp Ile Thr
  95                 100                 105                 110

 aag tgg agt tac tcc ctg tgc atc agc aat ctg act ctg aat gat gca      386
 Lys Trp Ser Tyr Ser Leu Cys Ile Ser Asn Leu Thr Leu Asn Asp Ala
                 115                 120                 125

 gga tcc tac aaa gcc cag ata aac caa agg aat ttt gaa gtc acc act      434
 Gly Ser Tyr Lys Ala Gln Ile Asn Gln Arg Asn Phe Glu Val Thr Thr
             130                 135                 140

 gag gag gaa ttc acc ctg ttc gtc tat gag cag ctg cag gag ccc caa      482
 Glu Glu Glu Phe Thr Leu Phe Val Tyr Glu Gln Leu Gln Glu Pro Gln
         145                 150                 155

 gtc acc atg aag tct gtg aag gtg tct gag aac ttc tcc tgt aac atc      530
 Val Thr Met Lys Ser Val Lys Val Ser Glu Asn Phe Ser Cys Asn Ile
     160                 165                 170

 act cta atg tgc tcc gtg aag ggg gca gag aaa agt gtt ctg tac agc      578
 Thr Leu Met Cys Ser Val Lys Gly Ala Glu Lys Ser Val Leu Tyr Ser
 175                 180                 185                 190

 tgg acc cca agg gaa ccc cat gct tct gag tcc aat gga ggc tcc att      626
 Trp Thr Pro Arg Glu Pro His Ala Ser Glu Ser Asn Gly Gly Ser Ile
                 195                 200                 205

 ctt acc gtc tcc cga aca cca tgt gac cca gac ctg cca tac atc tgc      674
 Leu Thr Val Ser Arg Thr Pro Cys Asp Pro Asp Leu Pro Tyr Ile Cys
             210                 215                 220

 aca gcc cag aac ccc gtc agc cag aga agc tcc ctc cct gtc cat gtt      722
 Thr Ala Gln Asn Pro Val Ser Gln Arg Ser Ser Leu Pro Val His Val
         225                 230                 235

 ggg cag ttc tgt aca gat cca gga gcc tcc aga ggg agg aac aac ggg      770
 Gly Gln Phe Cys Thr Asp Pro Gly Ala Ser Arg Gly Arg Asn Asn Gly
     240                 245                 250

 gga gac tgt ggt agg ggt cct ggg aga gcc agt cac cct gcc act tgc      818
 Gly Asp Cys Gly Arg Gly Pro Gly Arg Ala Ser His Pro Ala Thr Cys
 255                 260                 265                 270

 act ccc agc ctg ccg gga cac aga gaa ggt tgt ctg gtt gtt taa cac      866
 Thr Pro Ser Leu Pro Gly His Arg Glu Gly Cys Leu Val Val 
                 275                 280

 atccatcatt agcaaagaga gggaagaagc agcaacggca gatccactca ttaaatccag    926

 ggatccttac aagaacaggg tgtgggtctc cagccaggac tgctccctga agatcagcca    986

 gctgaagata gaggacgccg gcccctacca tgcctacgtg tgctcagagg cctccagcgt   1046

 caccagcatg acacatgtca ccctgctcat ctaccgcagg ctgaggaagc ccaaaatcac   1106

 gtggagcctc aggcacagtg aggatggcat ctgcaggatc agcctgacct gctccgtgga   1166

 ggacggggga aacactgtca tgtacacatg gaccccgctg cagaaggaag ctgttgtgtc   1226

 ccaaggggaa tcacacctca atgtctcatg gagaagcagt gaaaatcacc ccaacctcac   1286

 atgcacagcc agcaaccctg tcagcaggag ttcccaccag tttctttctg agaacatctg   1346

 ttcaggacct gagagaaaca caaagctttg gattgggttg ttcctgatgg tttgccttct   1406

 gtgcgttggg atcttcagct ggtgcatttg gaagcgaaaa ggacggtgtt cagtcccagc   1466

 cttctgttcc agccaagctg aggccccagc ggatacacca ggatatgaga agctggacac   1526

 tcccctcagg cctgccaggc aacagcctac acccacctca gacagcagct ctgacagcaa   1586

 cctcacaact gaggaggatg aggacaggcc tgaggtgcac aagcccatca gtggaagata   1646

 tgaggtgttt gaccaggtca ctcaggaggg cgctggacat gacccagccc ctgagggcca   1706

 agcagactat gatcccgtca ctccatatgt cacggaagtt gagtctgtgg ttggagagaa   1766

 caccgtgtat gcacaagtgt tcaacttaca gggaaagacc ccagtttctc agaaggaaga   1826

 gagctcagcc acaatctact gctccatacg gaaacctcag gtggtgccac caccacaaca   1886

 gaatgatctt gagattcctg aaagtcctac ctatgaaaat ttcacctgaa aggaaaagca   1946

 gctgctgcct ctctcctggg accgtggggt tggaaagtca gctggacctc atggggcctg   2006

 gggctcgctg acagaagcac ctcagaattt ccttcagtgc ctcagagatg cctggatgtg   2066

 gcccctcccc ctccttctca cccttaagga ctcccaaacc cattaatagt tcagacacag   2126

 gctccttctt ggagcctatg ggcttcagat gtctttgccc catttgtcac ctcgcacact   2186

 tatagcgttt cctcctcgaa attctaccaa gactggtcaa atgttgctga ggggcctgga   2246

 ccagctgtcc tttacaccac cttctcaaca ctgctgaaaa gaaccccaag agaattgtca   2306

 cacatgacac aagatgtaca taatatcatg ctcacgcctg gagtgttatt taaaataaaa   2366

 ggcaggaaat aaaaaaaaaa aa                                            2388




      <210> 302
      <211> 1896
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1896)

      <400> 302
  atg ggg ttg ccc agg ggg ccg gag ggc cag ggt ctc ccg gag gtg gaa      48
  Met Gly Leu Pro Arg Gly Pro Glu Gly Gln Gly Leu Pro Glu Val Glu
    1               5                  10                  15

 aca aga gaa gat gaa gaa caa aat gtc aag ttg act gaa att ctg gag       96
 Thr Arg Glu Asp Glu Glu Gln Asn Val Lys Leu Thr Glu Ile Leu Glu
              20                  25                  30

 ctc ttg gtt gca gct ggg tat ttc agg gca aga att aaa ggc tta tca      144
 Leu Leu Val Ala Ala Gly Tyr Phe Arg Ala Arg Ile Lys Gly Leu Ser
          35                  40                  45

 ccc ttt gac aag gta gta gga gga atg act tgg tgt atc acc act tgc      192
 Pro Phe Asp Lys Val Val Gly Gly Met Thr Trp Cys Ile Thr Thr Cys
      50                  55                  60

 aac ttt gat gta gat gtt gat ttg ctc ttt caa gaa aac tct acg ata      240
 Asn Phe Asp Val Asp Val Asp Leu Leu Phe Gln Glu Asn Ser Thr Ile
  65                  70                  75                  80

 ggt caa aaa ata gct ctg tca gaa aaa att gtc tcg gtc ctg cca agg      288
 Gly Gln Lys Ile Ala Leu Ser Glu Lys Ile Val Ser Val Leu Pro Arg
                  85                  90                  95

 atg aaa tgc cca cac cag ctg gag ccc cac cag atc cag ggg atg gat      336
 Met Lys Cys Pro His Gln Leu Glu Pro His Gln Ile Gln Gly Met Asp
             100                 105                 110

 ttt att cac ata ttt cct gtt gtt cag tgg ctg gtg aaa cga gct ata      384
 Phe Ile His Ile Phe Pro Val Val Gln Trp Leu Val Lys Arg Ala Ile
         115                 120                 125

 gaa aca aaa gaa gag atg ggt gac tat atc cgc tcc tac tct gta tcc      432
 Glu Thr Lys Glu Glu Met Gly Asp Tyr Ile Arg Ser Tyr Ser Val Ser
     130                 135                 140

 cag ttc cag aag act tac agt ctc cct gag gat gat gac ttc ata aag      480
 Gln Phe Gln Lys Thr Tyr Ser Leu Pro Glu Asp Asp Asp Phe Ile Lys
 145                 150                 155                 160

 aga aaa gaa aag gcc atc aag aca gtt gtg gac ctc tca gaa gtg tac      528
 Arg Lys Glu Lys Ala Ile Lys Thr Val Val Asp Leu Ser Glu Val Tyr
                 165                 170                 175

 aag ccc cgt cgg aaa tac aaa cgc cac cag gga gca gag gag cta ctt      576
 Lys Pro Arg Arg Lys Tyr Lys Arg His Gln Gly Ala Glu Glu Leu Leu
             180                 185                 190

 gat gaa gaa tct cga atc cat gct aca ctt ttg gaa tat ggc agg aga      624
 Asp Glu Glu Ser Arg Ile His Ala Thr Leu Leu Glu Tyr Gly Arg Arg
         195                 200                 205

 tat gga ttt agc cgc cag agc aaa atg gag aag gct gag gac aag aaa      672
 Tyr Gly Phe Ser Arg Gln Ser Lys Met Glu Lys Ala Glu Asp Lys Lys
     210                 215                 220

 acg gca ctt cca gca ggg ctg tca gct aca gaa aaa gct gat gcc cac      720
 Thr Ala Leu Pro Ala Gly Leu Ser Ala Thr Glu Lys Ala Asp Ala His
 225                 230                 235                 240

 gag gaa gat gag ctt cga gca gct gaa gag cag cgt att cag tcg ctg      768
 Glu Glu Asp Glu Leu Arg Ala Ala Glu Glu Gln Arg Ile Gln Ser Leu
                 245                 250                 255

 atg acc aag atg acc gct atg gca aat gag gag agc cgt ctc acc gca      816
 Met Thr Lys Met Thr Ala Met Ala Asn Glu Glu Ser Arg Leu Thr Ala
             260                 265                 270

 agc tcc gtg ggc cag att gtg gga ctc tgc tct gct gag atc aag cag      864
 Ser Ser Val Gly Gln Ile Val Gly Leu Cys Ser Ala Glu Ile Lys Gln
         275                 280                 285

 att gtg tcc gag tat gca gag aag cag tct gag cta tca gct gaa gaa      912
 Ile Val Ser Glu Tyr Ala Glu Lys Gln Ser Glu Leu Ser Ala Glu Glu
     290                 295                 300

 agt cca gaa aaa tta gga acc tcc cag cta cat cgc cgg aaa gtc att      960
 Ser Pro Glu Lys Leu Gly Thr Ser Gln Leu His Arg Arg Lys Val Ile
 305                 310                 315                 320

 tcc ttg aac aaa cag att gcg caa aag acc aaa cat ctt gaa gag ctg     1008
 Ser Leu Asn Lys Gln Ile Ala Gln Lys Thr Lys His Leu Glu Glu Leu
                 325                 330                 335

 cga gca agt cac acc agc cta caa gcc aga tat aat gaa gcc aag aaa     1056
 Arg Ala Ser His Thr Ser Leu Gln Ala Arg Tyr Asn Glu Ala Lys Lys
             340                 345                 350

 acg ctg aca gag ctg aag act tac agt gag aaa ctg gac aaa gag caa     1104
 Thr Leu Thr Glu Leu Lys Thr Tyr Ser Glu Lys Leu Asp Lys Glu Gln
         355                 360                 365

 gca gcc ctc gag aag ata gaa tcc aaa gct gat cca agt atc cta cag     1152
 Ala Ala Leu Glu Lys Ile Glu Ser Lys Ala Asp Pro Ser Ile Leu Gln
     370                 375                 380

 aac ctg aga gca ctt gta gcc atg aat gaa aat ctg aaa agt caa gaa     1200
 Asn Leu Arg Ala Leu Val Ala Met Asn Glu Asn Leu Lys Ser Gln Glu
 385                 390                 395                 400

 cag gaa ttt aaa gca cat tgt cga gag gag atg aca cga cta cag caa     1248
 Gln Glu Phe Lys Ala His Cys Arg Glu Glu Met Thr Arg Leu Gln Gln
                 405                 410                 415

 gaa att gaa aac ctg aaa gct gag aga gca cca cgt gga gat gaa aag     1296
 Glu Ile Glu Asn Leu Lys Ala Glu Arg Ala Pro Arg Gly Asp Glu Lys
             420                 425                 430

 acc ctc tcc agt gga gag ccg cct ggt acc ttg acc tct gca atg act     1344
 Thr Leu Ser Ser Gly Glu Pro Pro Gly Thr Leu Thr Ser Ala Met Thr
         435                 440                 445

 cat gac gaa gac cta gac aga cgg tat aat atg gag aaa gag aaa ctt     1392
 His Asp Glu Asp Leu Asp Arg Arg Tyr Asn Met Glu Lys Glu Lys Leu
     450                 455                 460

 tac aag ata cgt tta cta cag gct cga aga aat cga gaa ata gca att     1440
 Tyr Lys Ile Arg Leu Leu Gln Ala Arg Arg Asn Arg Glu Ile Ala Ile
 465                 470                 475                 480

 ttg cac cgc aag att gat gaa gtc cct agc cgt gcc gag cta ata cag     1488
 Leu His Arg Lys Ile Asp Glu Val Pro Ser Arg Ala Glu Leu Ile Gln
                 485                 490                 495

 tat cag aag aga ttt att gaa ctc tac cgc cag att tca gca gtg cac     1536
 Tyr Gln Lys Arg Phe Ile Glu Leu Tyr Arg Gln Ile Ser Ala Val His
             500                 505                 510

 aaa gaa acc aag cag ttc ttc act tta tat aat acc ctg gat gat aaa     1584
 Lys Glu Thr Lys Gln Phe Phe Thr Leu Tyr Asn Thr Leu Asp Asp Lys
         515                 520                 525

 aag gtt tat ttg gaa aaa gag att agt ctg ctg aac tca att cat gag     1632
 Lys Val Tyr Leu Glu Lys Glu Ile Ser Leu Leu Asn Ser Ile His Glu
     530                 535                 540

 aac ttc tca cag gcc atg gcc tcc cct gct gcc cgg gac cag ttt tta     1680
 Asn Phe Ser Gln Ala Met Ala Ser Pro Ala Ala Arg Asp Gln Phe Leu
 545                 550                 555                 560

 cgt cag atg gaa cag att gtg gaa gga att aag caa agt aga atg aag     1728
 Arg Gln Met Glu Gln Ile Val Glu Gly Ile Lys Gln Ser Arg Met Lys
                 565                 570                 575

 atg gaa aag aaa aag caa gag aac aaa atg aga aga gac cag ttg aac     1776
 Met Glu Lys Lys Lys Gln Glu Asn Lys Met Arg Arg Asp Gln Leu Asn
             580                 585                 590

 gac cag tac ttg gag ctg tta gaa aag cag agg cta tac ttt aag act     1824
 Asp Gln Tyr Leu Glu Leu Leu Glu Lys Gln Arg Leu Tyr Phe Lys Thr
         595                 600                 605

 gtg aaa gag ttc aag gag gag ggc cgc aag aac gag atg ctg ctg tcc     1872
 Val Lys Glu Phe Lys Glu Glu Gly Arg Lys Asn Glu Met Leu Leu Ser
     610                 615                 620

 aag gtg aaa gcg aag gcc tcc tga                                     1896
 Lys Val Lys Ala Lys Ala Ser 
 625                 630





      <210> 303
      <211> 1872
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (843)..(1301)

      <400> 303
 aatcattgaa cgcaatcgaa tggaatcatc gagtggaatc gaatggaatc atgatcaaat     60

 ggaatcgaat gtaatcatca tcaaatggaa tccaaaatca ccatcatcaa ttggtactga    120

 atggaattgt catcaaatgg aattcaaagg aatcatcatc aaatggaacc gaatggaatc    180

 ctcattgaat ggaaatgaaa ggagtcatca tctaatggaa tcgcatggaa tcatcatcaa    240

 atggaatcga atggaatcat catcaaatgg aatctaatgg aatcattgaa cggaattgaa    300

 tggaatcgtc atcgaatgaa ttgaatgcaa tcaacgaatg gtctcgaatg gaaccacctc    360

 caaatggaat ggaatggaat catcgcatag aatcgaatgg aattatcatc gaatggacta    420

 aaatggaatc aacatcaatc ggaatcaaac ggaattatcg aatggaatcg aagagaatca    480

 tcgaatggac tcgaatggga tcatctaatg aaatagaatg gaataatcca tggactcgaa    540

 tgcaatcatc atcaaatgga atcgaatgga atcgtcgaat ggactcgaat gcaataaaca    600

 ttgaatggaa tcgaatggaa tcatcatcgg aggaaaacga atggaattat catcgaaagg    660

 aatcgaatgg aatcatcaaa ttgaatcaga tggaatcatc atcaagtgga atcaaaaata    720

 accatcatca attggaattg aatggaattg tcatcaaatg gaattcaaag gaatcatcat    780

 caaatggaac cgaatggaat cctcattgaa tggaaatgaa aggggtcatc taatggaatc    840

 gc   atg gaa tca tca tca aat gga atc gaa tgg aat cat cat caa atg     887
      Met Glu Ser Ser Ser Asn Gly Ile Glu Trp Asn His His Gln Met
        1               5                  10                  15

 gtc tcg aat gga atc att gaa cag aat tta atg gaa tcg tca ttg aat      935
 Val Ser Asn Gly Ile Ile Glu Gln Asn Leu Met Glu Ser Ser Leu Asn
                  20                  25                  30

 gaa ttg aat gca atc atc gaa tgg tct cga atg gaa tca tct tct aat      983
 Glu Leu Asn Ala Ile Ile Glu Trp Ser Arg Met Glu Ser Ser Ser Asn
              35                  40                  45

 gga aag gaa tgg aat cat cgc ata gaa tcg aat gga att atc atc gaa     1031
 Gly Lys Glu Trp Asn His Arg Ile Glu Ser Asn Gly Ile Ile Ile Glu
          50                  55                  60

 tgg aat cga atg gta tca aca cca aac gga aaa aaa cgg aat ttt cga     1079
 Trp Asn Arg Met Val Ser Thr Pro Asn Gly Lys Lys Arg Asn Phe Arg
      65                  70                  75

 atg gaa acg aag aga atc ttc gaa cgg acc cga atg gaa tta tct aat     1127
 Met Glu Thr Lys Arg Ile Phe Glu Arg Thr Arg Met Glu Leu Ser Asn
  80                  85                  90                  95

 gga atg gaa tgg aat aat cca tgg act cga atg caa tca tca tcg aat     1175
 Gly Met Glu Trp Asn Asn Pro Trp Thr Arg Met Gln Ser Ser Ser Asn
                 100                 105                 110

 gga atc gaa tgg aac cat cga atg gac tca aat gga ata atc att gaa     1223
 Gly Ile Glu Trp Asn His Arg Met Asp Ser Asn Gly Ile Ile Ile Glu
             115                 120                 125

 cgg aat cga atg gaa tca tca tcg gat gga aac gaa tgg aat cat cat     1271
 Arg Asn Arg Met Glu Ser Ser Ser Asp Gly Asn Glu Trp Asn His His
         130                 135                 140

 cga atg gaa atg aaa gga gtc atc atc taa t ggaattgcat ggaatcatca     1322
 Arg Met Glu Met Lys Gly Val Ile Ile 
     145                 150

 tcaaatggaa tcgaatggaa tcaacatcaa atggagtcaa atggaatcat gatgtagaaa   1382

 tgagagtcta ataagaaaga cagaaatata tagaatcata ttttaaaatg ttttatattt   1442

 gtattggtct tctacgcttg tttaacatcc cccgccaccc accccaagcc taaatatgtc   1502

 actattgtta ttatcatttg cttcttgtct ggtttctttg ccagagagat gaaaacaaat   1562

 catttttttg ctcaaggtaa tgagaaagaa aggaagaaaa ataggaaaac agaaagaata   1622

 ctggatactt tgaaaggaca tgatgaattt aagtgattgg gacagcttga accgggtgta   1682

 ttcagcaata taaccccttg ctgttatgcc actaaatatt taccattgtc acttgctttc   1742

 ataattgcta tgggtctttt gagagttttt aattgatttt gccacttgtg cctggttgcg   1802

 gtcctctggc taatttagat ttaaacattt atcagtgagg taaataataa attttgcttg   1862

 gattgaacat                                                          1872




      <210> 304
      <211> 522
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (142)..(522)

      <400> 304
 acaaagaggt aacgtgccta gtccaggtct atatagatag tggcaaagtc agaacacact     60

 tccagggctt cagactccta atgccctcct agcacctctg agaaactgca gcagggatcc    120

 taagacagtc ttagtgtttc a  atg gcc aag ggg act agg ctg atg gat ata     171
                          Met Ala Lys Gly Thr Arg Leu Met Asp Ile
                            1               5                  10

 att att gtc agg gca tac tgc aaa gag aag aaa gaa tcc cta aaa tgt      219
 Ile Ile Val Arg Ala Tyr Cys Lys Glu Lys Lys Glu Ser Leu Lys Cys
                  15                  20                  25

 att aca ggt gct gat acc ata tcc tgc aca agt gtt ccc tct ctt gtt      267
 Ile Thr Gly Ala Asp Thr Ile Ser Cys Thr Ser Val Pro Ser Leu Val
              30                  35                  40

 ctc atc cac acc cat caa cca ata cca aat gcc atc cta gac ctg ggg      315
 Leu Ile His Thr His Gln Pro Ile Pro Asn Ala Ile Leu Asp Leu Gly
          45                  50                  55

 cca tgg gac ctg tcc gcc tct ccc cca gtt gta ggt ccc ctg ttt aac      363
 Pro Trp Asp Leu Ser Ala Ser Pro Pro Val Val Gly Pro Leu Phe Asn
      60                  65                  70

 acc atc cca ctt aca tta gac atg gtt ctt aac aag gct aag ctg gct      411
 Thr Ile Pro Leu Thr Leu Asp Met Val Leu Asn Lys Ala Lys Leu Ala
  75                  80                  85                  90

 gaa atg aca gaa atg aaa ttc aga cta tgg ata gga atg aag atc atc      459
 Glu Met Thr Glu Met Lys Phe Arg Leu Trp Ile Gly Met Lys Ile Ile
                  95                 100                 105

 aag atc cag gag gat ggc aaa atc caa tcc aag gaa att gag gat cac      507
 Lys Ile Gln Glu Asp Gly Lys Ile Gln Ser Lys Glu Ile Glu Asp His
             110                 115                 120

 aat aaa atg ata tag                                                  522
 Asn Lys Met Ile 
         125





      <210> 305
      <211> 3462
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (17)..(3118)

      <400> 305
 caagtgcaag ccccag    atg aat tac gac aag ctg agc cgg gcc ctg cgc      49
                      Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu Arg
                        1               5                  10

 tat tac tat aac aag cgc att ctg cac aag acc aag ggg aaa cgg ttc       97
 Tyr Tyr Tyr Asn Lys Arg Ile Leu His Lys Thr Lys Gly Lys Arg Phe
              15                  20                  25

 acc tac aag ttc aat ttc aac aaa ctg gtg ctg gtc aat tac cca ttc      145
 Thr Tyr Lys Phe Asn Phe Asn Lys Leu Val Leu Val Asn Tyr Pro Phe
          30                  35                  40

 att gat gtg ggg ttg gct ggg ggt gca gtg ccc cag agt gcc ccg cca      193
 Ile Asp Val Gly Leu Ala Gly Gly Ala Val Pro Gln Ser Ala Pro Pro
      45                  50                  55

 gtg ccg tcg ggt ggt agc cac ttc cgc ttc cct ccc tca acg ccc tcc      241
 Val Pro Ser Gly Gly Ser His Phe Arg Phe Pro Pro Ser Thr Pro Ser
  60                  65                  70                  75

 gag gtg ctg tcc ccc acc gag gac ccc cgc tca cca cca gcc tgc tct      289
 Glu Val Leu Ser Pro Thr Glu Asp Pro Arg Ser Pro Pro Ala Cys Ser
                  80                  85                  90

 tca tct tca tct tcc ctc ttc tcg gct gtg gtg gcc cgc cgc ctg ggc      337
 Ser Ser Ser Ser Ser Leu Phe Ser Ala Val Val Ala Arg Arg Leu Gly
              95                 100                 105

 cga ggc tca gtc agt gac tgt agt gat ggc acg tca gag ctg gag gaa      385
 Arg Gly Ser Val Ser Asp Cys Ser Asp Gly Thr Ser Glu Leu Glu Glu
         110                 115                 120

 ccg ctg gga gag gat ccc cgc gcc cga cca ccc ggc cct ccg gat ctg      433
 Pro Leu Gly Glu Asp Pro Arg Ala Arg Pro Pro Gly Pro Pro Asp Leu
     125                 130                 135

 ggt gcc ttc cga ggg ccc ccg ctg gcc cgc ctg ccc cat gac cct ggt      481
 Gly Ala Phe Arg Gly Pro Pro Leu Ala Arg Leu Pro His Asp Pro Gly
 140                 145                 150                 155

 gtc ttc cga gtc tat ccc cgg cct cgg ggt ggc cct gaa ccc ctc agc      529
 Val Phe Arg Val Tyr Pro Arg Pro Arg Gly Gly Pro Glu Pro Leu Ser
                 160                 165                 170

 ccc ttc cct gtg tcg cct ctg gcc ggt cct gga tcc ctg ctg ccc cct      577
 Pro Phe Pro Val Ser Pro Leu Ala Gly Pro Gly Ser Leu Leu Pro Pro
             175                 180                 185

 cag ctc tcc ccg gct ctg ccc atg acg ccc acc cac ctg gcc tac act      625
 Gln Leu Ser Pro Ala Leu Pro Met Thr Pro Thr His Leu Ala Tyr Thr
         190                 195                 200

 ccc tcg ccc acg ctg agc ccg atg tac ccc agt ggt ggc ggg ggg ccc      673
 Pro Ser Pro Thr Leu Ser Pro Met Tyr Pro Ser Gly Gly Gly Gly Pro
     205                 210                 215

 agc ggc tca ggg gga ggc tcc cac ttc tcc ttc agc cct gag gac atg      721
 Ser Gly Ser Gly Gly Gly Ser His Phe Ser Phe Ser Pro Glu Asp Met
 220                 225                 230                 235

 aaa cgg tac ctg cag gcc cac acc caa agc gtc tac aac tac cac ctc      769
 Lys Arg Tyr Leu Gln Ala His Thr Gln Ser Val Tyr Asn Tyr His Leu
                 240                 245                 250

 agc ccc cgc gcc ttc ctg cac tac cct ggg ctg gtg gtg ccc cag ccc      817
 Ser Pro Arg Ala Phe Leu His Tyr Pro Gly Leu Val Val Pro Gln Pro
             255                 260                 265

 cag cgc cct gac aag tgc ccg ctg ccg ccc atg gca ccc gag acc cca      865
 Gln Arg Pro Asp Lys Cys Pro Leu Pro Pro Met Ala Pro Glu Thr Pro
         270                 275                 280

 ccg gtc ccc tcc tcg gcc tcg tca tcc tct tct tct tct tcc tcc cca      913
 Pro Val Pro Ser Ser Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Pro
     285                 290                 295

 ttc aag ttt aag ctc cag ccg ccc cca ctc gga cgc cgg cag cgg gca      961
 Phe Lys Phe Lys Leu Gln Pro Pro Pro Leu Gly Arg Arg Gln Arg Ala
 300                 305                 310                 315

 gct ggg gag aag gcc gta gcc ggt gct gac aag agc ggt ggc agt gca     1009
 Ala Gly Glu Lys Ala Val Ala Gly Ala Asp Lys Ser Gly Gly Ser Ala
                 320                 325                 330

 ggc ggg ctg gct gag ggg gca ggg gcg cta gcc cca ccg ccc ccg cca     1057
 Gly Gly Leu Ala Glu Gly Ala Gly Ala Leu Ala Pro Pro Pro Pro Pro
             335                 340                 345

 cca cag atc aag gtg gag ccc atc tcg gaa ggc gag tcg gag gag gta     1105
 Pro Gln Ile Lys Val Glu Pro Ile Ser Glu Gly Glu Ser Glu Glu Val
         350                 355                 360

 gag gtg act gac atc agt gat gag gat gag gaa gac ggg gag gtg ttc     1153
 Glu Val Thr Asp Ile Ser Asp Glu Asp Glu Glu Asp Gly Glu Val Phe
     365                 370                 375

 aag acg ccc cgt gcc cca cct gca ccc cct aag cct gag ccc ggc gag     1201
 Lys Thr Pro Arg Ala Pro Pro Ala Pro Pro Lys Pro Glu Pro Gly Glu
 380                 385                 390                 395

 gca ccc ggg gca tcc cag tgc atg ccc ctc aag cta cgc ttt aag cgg     1249
 Ala Pro Gly Ala Ser Gln Cys Met Pro Leu Lys Leu Arg Phe Lys Arg
                 400                 405                 410

 cgc tgg agt gaa gac tgt cgc ctc gaa ggg ggt ggg ggc ccc gct ggg     1297
 Arg Trp Ser Glu Asp Cys Arg Leu Glu Gly Gly Gly Gly Pro Ala Gly
             415                 420                 425

 ggc ttt gag gat gag ggt gag gac aag aag tcg gct gac aga tta ccc     1345
 Gly Phe Glu Asp Glu Gly Glu Asp Lys Lys Ser Ala Asp Arg Leu Pro
         430                 435                 440

 tgg act cca ttt ccc gac gta cag cgt gac ccg tca ttc ccg ccc atc     1393
 Trp Thr Pro Phe Pro Asp Val Gln Arg Asp Pro Ser Phe Pro Pro Ile
     445                 450                 455

 att ccc gcg gtc tac tct gag gct ttt gtg gac ttc att tcc cgg cgt     1441
 Ile Pro Ala Val Tyr Ser Glu Ala Phe Val Asp Phe Ile Ser Arg Arg
 460                 465                 470                 475

 gcc acg cgg ctc tct gtg cgg gcc gag ggc ggt gac ggc ggc gcg gac     1489
 Ala Thr Arg Leu Ser Val Arg Ala Glu Gly Gly Asp Gly Gly Ala Asp
                 480                 485                 490

 gac agc cgg act gca tct ccc ggc gtg ccc cgc ggc ggg cgc tgg gcc     1537
 Asp Ser Arg Thr Ala Ser Pro Gly Val Pro Arg Gly Gly Arg Trp Ala
             495                 500                 505

 gga gcc gga gcc caa gcc aga gcg gcg cgg cct gga aga ggc cag ggc     1585
 Gly Ala Gly Ala Gln Ala Arg Ala Ala Arg Pro Gly Arg Gly Gln Gly
         510                 515                 520

 ccg ggg gag gcg gcg gca gcg gcg gcg gct ggg gca gcc cgg gca gcc     1633
 Pro Gly Glu Ala Ala Ala Ala Ala Ala Ala Gly Ala Ala Arg Ala Ala
     525                 530                 535

 cga gcc ccg cag cct ggg cct gtg ctc ggc gcc atg agc ggc ggc ggg     1681
 Arg Ala Pro Gln Pro Gly Pro Val Leu Gly Ala Met Ser Gly Gly Gly
 540                 545                 550                 555

 cct tcg gga ggc ggc cct ggg ggc tcg ggc agg gcg cgg act agc tcg     1729
 Pro Ser Gly Gly Gly Pro Gly Gly Ser Gly Arg Ala Arg Thr Ser Ser
                 560                 565                 570

 ttc gcg gag ccc ggc ggc gga ggc gga gga ggc ggc ggc ggc ccc gga     1777
 Phe Ala Glu Pro Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Pro Gly
             575                 580                 585

 ggc tcg gcc tcc ggc cca ggc ggc acc ggc ggc gga aag gca tct gtc     1825
 Gly Ser Ala Ser Gly Pro Gly Gly Thr Gly Gly Gly Lys Ala Ser Val
         590                 595                 600

 ggg gcc atg ggt ggg ggc gtc ggg gcc tcg agc tcc ggg ggt gga ccc     1873
 Gly Ala Met Gly Gly Gly Val Gly Ala Ser Ser Ser Gly Gly Gly Pro
     605                 610                 615

 ggc ggc agc ggc gga gga ggc agc gga ggc ccc ggc gca ggc act agc     1921
 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Pro Gly Ala Gly Thr Ser
 620                 625                 630                 635

 ttc ccg ccg ccc ggg gtg aag ctg ggc cgt gac agc ggg aag gtg acc     1969
 Phe Pro Pro Pro Gly Val Lys Leu Gly Arg Asp Ser Gly Lys Val Thr
                 640                 645                 650

 aca gtc gta gcc act cta ggc caa ggc cca gag cgc tcc caa gaa gtg     2017
 Thr Val Val Ala Thr Leu Gly Gln Gly Pro Glu Arg Ser Gln Glu Val
             655                 660                 665

 gct tac acg gac atc aaa gtg att ggc aat ggc tca ttt ggg gtc gtg     2065
 Ala Tyr Thr Asp Ile Lys Val Ile Gly Asn Gly Ser Phe Gly Val Val
         670                 675                 680

 tac cag gca cgg ctg gca gag acc agg gaa cta gtc gcc atc aag aag     2113
 Tyr Gln Ala Arg Leu Ala Glu Thr Arg Glu Leu Val Ala Ile Lys Lys
     685                 690                 695

 gtt ctc cag gac aag agg ttc aag aac cga gag ctg cag atc atg cgt     2161
 Val Leu Gln Asp Lys Arg Phe Lys Asn Arg Glu Leu Gln Ile Met Arg
 700                 705                 710                 715

 aag ctg gac cac tgc aat att gtg agg ctg aga tac ttt ttc tac tcc     2209
 Lys Leu Asp His Cys Asn Ile Val Arg Leu Arg Tyr Phe Phe Tyr Ser
                 720                 725                 730

 agt ggc gag aag aaa gac gag ctt tac cta aat ctg gtg ctg gaa tat     2257
 Ser Gly Glu Lys Lys Asp Glu Leu Tyr Leu Asn Leu Val Leu Glu Tyr
             735                 740                 745

 gtg ccc gag aca gtg tac cgg gtg gcc cgc cac ttc acc aag gcc aag     2305
 Val Pro Glu Thr Val Tyr Arg Val Ala Arg His Phe Thr Lys Ala Lys
         750                 755                 760

 ttg acc atc cct atc ctc tat gtc aag gtg tac atg tac cag ctc ttc     2353
 Leu Thr Ile Pro Ile Leu Tyr Val Lys Val Tyr Met Tyr Gln Leu Phe
     765                 770                 775

 cgc agc ttg gcc tac atc cac tcc cag ggc gtg tgt cac cgc gac atc     2401
 Arg Ser Leu Ala Tyr Ile His Ser Gln Gly Val Cys His Arg Asp Ile
 780                 785                 790                 795

 aag ccc cag aac ctg ctg gtg gac cct gac act gct gtc ctc aag ctc     2449
 Lys Pro Gln Asn Leu Leu Val Asp Pro Asp Thr Ala Val Leu Lys Leu
                 800                 805                 810

 tgc gat ttt ggc ggt gca aag cag ttg gtc cga ggg gag ccc aat gtc     2497
 Cys Asp Phe Gly Gly Ala Lys Gln Leu Val Arg Gly Glu Pro Asn Val
             815                 820                 825

 tcc tac atc tgt tct cgc tac tac cgg gcc cca gag ctc atc ttt gga     2545
 Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala Pro Glu Leu Ile Phe Gly
         830                 835                 840

 gcc act gat tac acc tca tcc atc gat gtt tgg tca gct ggc tgt gta     2593
 Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val Trp Ser Ala Gly Cys Val
     845                 850                 855

 ctg gca gag ctc ctc ttg ggc cag ccc atc ttc cct ggg gac agt ggg     2641
 Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile Phe Pro Gly Asp Ser Gly
 860                 865                 870                 875

 gtg gac cag ctg gtg gag atc atc aag gtg ctg gga aca cca acc cgg     2689
 Val Asp Gln Leu Val Glu Ile Ile Lys Val Leu Gly Thr Pro Thr Arg
                 880                 885                 890

 gaa caa atc cga gag atg aac ccc aac tac acg gag ttc aag ttc cct     2737
 Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr Thr Glu Phe Lys Phe Pro
             895                 900                 905

 cag att aaa gct cac ccc tgg aca aag gtg ttc aaa tct cga acg ccg     2785
 Gln Ile Lys Ala His Pro Trp Thr Lys Val Phe Lys Ser Arg Thr Pro
         910                 915                 920

 cca gag gcc atc gcg ctc tgc tct agc ctg ctg gag tac acc cca tcc     2833
 Pro Glu Ala Ile Ala Leu Cys Ser Ser Leu Leu Glu Tyr Thr Pro Ser
     925                 930                 935

 tca agg ctc tcc cca cta gag gcc tgt gcg cac agc ttc ttt gat gaa     2881
 Ser Arg Leu Ser Pro Leu Glu Ala Cys Ala His Ser Phe Phe Asp Glu
 940                 945                 950                 955

 ctg cga tgt ctg gga acc cag ctg cct aac aac cgc cca ctt ccc cct     2929
 Leu Arg Cys Leu Gly Thr Gln Leu Pro Asn Asn Arg Pro Leu Pro Pro
                 960                 965                 970

 ctc ttc aac ttc agt gct ggt gaa ctc tcc atc caa ccg tct ctc aac     2977
 Leu Phe Asn Phe Ser Ala Gly Glu Leu Ser Ile Gln Pro Ser Leu Asn
             975                 980                 985

 gcc att ctc atc cct cct cac ttg agg tcc cca gcg ggc act acc acc     3025
 Ala Ile Leu Ile Pro Pro His Leu Arg Ser Pro Ala Gly Thr Thr Thr
         990                 995                1000

 ctc acc ccg tcc tca caa gct tta act gag act ccg acc agc tca gac     3073
 Leu Thr Pro Ser Ser Gln Ala Leu Thr Glu Thr Pro Thr Ser Ser Asp
    1005                1010                1015

 tgg cag tcg acc gat gcc aca cct acc ctc act aac tcc tcc tga ggg     3121
 Trp Gln Ser Thr Asp Ala Thr Pro Thr Leu Thr Asn Ser Ser 
1020                1025                1030

 ccccaccaag cacccttcca cttccatctg ggagccccaa gaggggctgg gaaggggggc   3181

 catagcccat caagctcctg ccctggctgg gcccctagac tagagggcag agaaaacgtc   3241

 gattcgcacc gtccaacctg gccccgcccc tcctacagct gtaactcccc tcctgtcctc   3301

 tgcccccaag gtctactccc tcctcaccgc accctggagg gccaggggag tggagagagc   3361

 tcctgatgtc ttagtttcca cagtaaggtt tgcctgtgta cagacctccg ttcaataaat   3421

 tattggcatg aaaaaaaaaa aaaaaaaaaa aaattggcgc g                       3462




      <210> 306
      <211> 3424
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(3374)

      <400> 306
 gggagccgcg gcccggaatc ggggcgcttc gccccgggcc ccccagc  atg aag acc      56
                                                      Met Lys Thr
                                                        1

 ccg gcg gac aca ggg ttt gcc ttc ccg gat tgg gcc tac aag cca gag      104
 Pro Ala Asp Thr Gly Phe Ala Phe Pro Asp Trp Ala Tyr Lys Pro Glu
       5                  10                  15

 tcg tcc cct ggc tca agg cag atc cag ctg tgg cac ttt atc ctg gag      152
 Ser Ser Pro Gly Ser Arg Gln Ile Gln Leu Trp His Phe Ile Leu Glu
  20                  25                  30                  35

 ctg ctg cgg aag gag gag tac cag ggc gtc att gcc tgg cag ggg gac      200
 Leu Leu Arg Lys Glu Glu Tyr Gln Gly Val Ile Ala Trp Gln Gly Asp
                  40                  45                  50

 tac ggg gaa ttc gtc atc aaa gac cct gat gag gtg gcc cgg ctg tgg      248
 Tyr Gly Glu Phe Val Ile Lys Asp Pro Asp Glu Val Ala Arg Leu Trp
              55                  60                  65

 ggc gtt cgc aag tgc aag ccc cag atg aat tac gac aag ctg agc cgg      296
 Gly Val Arg Lys Cys Lys Pro Gln Met Asn Tyr Asp Lys Leu Ser Arg
          70                  75                  80

 gcc ctg cgc tat tac tat aac aag cgc att ctg cac aag acc aag ggg      344
 Ala Leu Arg Tyr Tyr Tyr Asn Lys Arg Ile Leu His Lys Thr Lys Gly
      85                  90                  95

 aaa cgg ttc acc tac aag ttc aat ttc aac aaa ctg gtg ctg gtc aat      392
 Lys Arg Phe Thr Tyr Lys Phe Asn Phe Asn Lys Leu Val Leu Val Asn
 100                 105                 110                 115

 tac cca ttc att gat gtg ggg ttg gct ggg ggt gca gtg ccc cag agt      440
 Tyr Pro Phe Ile Asp Val Gly Leu Ala Gly Gly Ala Val Pro Gln Ser
                 120                 125                 130

 gcc ccg cca gtg ccg tcg ggt ggt agc cac ttc cgc ttc cct ccc tca      488
 Ala Pro Pro Val Pro Ser Gly Gly Ser His Phe Arg Phe Pro Pro Ser
             135                 140                 145

 acg ccc tcc gag gtg ctg tcc ccc acc gag gac ccc cgc tca cca cca      536
 Thr Pro Ser Glu Val Leu Ser Pro Thr Glu Asp Pro Arg Ser Pro Pro
         150                 155                 160

 gcc tgc tct tca tct tca tct tcc ctc ttc tcg gct gtg gtg gcc cgc      584
 Ala Cys Ser Ser Ser Ser Ser Ser Leu Phe Ser Ala Val Val Ala Arg
     165                 170                 175

 cgc ctg ggc cga ggc tca gtc agt gac tgt agt gat ggc acg tca gag      632
 Arg Leu Gly Arg Gly Ser Val Ser Asp Cys Ser Asp Gly Thr Ser Glu
 180                 185                 190                 195

 ctg gag gaa ccg ctg gga gag gat ccc cgc gcc cga cca ccc ggc cct      680
 Leu Glu Glu Pro Leu Gly Glu Asp Pro Arg Ala Arg Pro Pro Gly Pro
                 200                 205                 210

 ccg gat ctg ggt gcc ttc cga ggg ccc ccg ctg gcc cgc ctg ccc cat      728
 Pro Asp Leu Gly Ala Phe Arg Gly Pro Pro Leu Ala Arg Leu Pro His
             215                 220                 225

 gac cct ggt gtc ttc cga gtc tat ccc cgg cct cgg ggt ggc cct gaa      776
 Asp Pro Gly Val Phe Arg Val Tyr Pro Arg Pro Arg Gly Gly Pro Glu
         230                 235                 240

 ccc ctc agc ccc ttc cct gtg tcg cct ctg gcc ggt cct gga tcc ctg      824
 Pro Leu Ser Pro Phe Pro Val Ser Pro Leu Ala Gly Pro Gly Ser Leu
     245                 250                 255

 ctg ccc cct cag ctc tcc ccg gct ctg ccc atg acg ccc acc cac ctg      872
 Leu Pro Pro Gln Leu Ser Pro Ala Leu Pro Met Thr Pro Thr His Leu
 260                 265                 270                 275

 gcc tac act ccc tcg ccc acg ctg agc ccg atg tac ccc agt ggt ggc      920
 Ala Tyr Thr Pro Ser Pro Thr Leu Ser Pro Met Tyr Pro Ser Gly Gly
                 280                 285                 290

 ggg ggg ccc agc ggc tca ggg gga ggc tcc cac ttc tcc ttc agc cct      968
 Gly Gly Pro Ser Gly Ser Gly Gly Gly Ser His Phe Ser Phe Ser Pro
             295                 300                 305

 gag gac atg aaa cgg tac ctg cag gcc cac acc caa agc gtc tac aac     1016
 Glu Asp Met Lys Arg Tyr Leu Gln Ala His Thr Gln Ser Val Tyr Asn
         310                 315                 320

 tac cac ctc agc ccc cgc gcc ttc ctg cac tac cct ggg ctg gtg gtg     1064
 Tyr His Leu Ser Pro Arg Ala Phe Leu His Tyr Pro Gly Leu Val Val
     325                 330                 335

 ccc cag ccc cag cgc cct gac aag tgc ccg ctg ccg ccc atg gca ccc     1112
 Pro Gln Pro Gln Arg Pro Asp Lys Cys Pro Leu Pro Pro Met Ala Pro
 340                 345                 350                 355

 gag acc cca ccg gtc ccc tcc tcg gcc tcg tca tcc tct tct tct tct     1160
 Glu Thr Pro Pro Val Pro Ser Ser Ala Ser Ser Ser Ser Ser Ser Ser
                 360                 365                 370

 tcc tcc cca ttc aag ttt aag ctc cag ccg ccc cca ctc gga cgc cgg     1208
 Ser Ser Pro Phe Lys Phe Lys Leu Gln Pro Pro Pro Leu Gly Arg Arg
             375                 380                 385

 cag cgg gca gct ggg gag aag gcc gta gcc ggt gct gac aag agc ggt     1256
 Gln Arg Ala Ala Gly Glu Lys Ala Val Ala Gly Ala Asp Lys Ser Gly
         390                 395                 400

 ggc agt gca ggc ggg ctg gct gag ggg gca ggg gcg cta gcc cca ccg     1304
 Gly Ser Ala Gly Gly Leu Ala Glu Gly Ala Gly Ala Leu Ala Pro Pro
     405                 410                 415

 ccc ccg cca cca cag atc aag gtg gag ccc atc tcg gaa ggc gag tcg     1352
 Pro Pro Pro Pro Gln Ile Lys Val Glu Pro Ile Ser Glu Gly Glu Ser
 420                 425                 430                 435

 gag gag gta gag gtg act gac atc agt gat gag gat gag gaa gac ggg     1400
 Glu Glu Val Glu Val Thr Asp Ile Ser Asp Glu Asp Glu Glu Asp Gly
                 440                 445                 450

 gag gtg ttc aag acg ccc cgt gcc cca cct gca ccc cct aag cct gag     1448
 Glu Val Phe Lys Thr Pro Arg Ala Pro Pro Ala Pro Pro Lys Pro Glu
             455                 460                 465

 ccc ggc gag gca ccc ggg gca tcc cag tgc atg ccc ctc aag cta cgc     1496
 Pro Gly Glu Ala Pro Gly Ala Ser Gln Cys Met Pro Leu Lys Leu Arg
         470                 475                 480

 ttt aag cgg cgc tgg agt gaa gac tgt cgc ctc gaa ggg ggt ggg ggc     1544
 Phe Lys Arg Arg Trp Ser Glu Asp Cys Arg Leu Glu Gly Gly Gly Gly
     485                 490                 495

 ccc gct ggg ggc ttt gag gat gag ggt gag gac aag aag tcg gct gac     1592
 Pro Ala Gly Gly Phe Glu Asp Glu Gly Glu Asp Lys Lys Ser Ala Asp
 500                 505                 510                 515

 aga tta ccc tgg act cca ttt ccc gac gta cag cgt gac ccg tca ttc     1640
 Arg Leu Pro Trp Thr Pro Phe Pro Asp Val Gln Arg Asp Pro Ser Phe
                 520                 525                 530

 ccg ccc atc att ccc gcg gtc tac tct gag gct ttt gtg gac ttc att     1688
 Pro Pro Ile Ile Pro Ala Val Tyr Ser Glu Ala Phe Val Asp Phe Ile
             535                 540                 545

 tcc cgg cgt gcc acg cgg ctc tct gtg cgg gcc gag ggc ggt gac ggc     1736
 Ser Arg Arg Ala Thr Arg Leu Ser Val Arg Ala Glu Gly Gly Asp Gly
         550                 555                 560

 ggc gcg gac gac agc cgg act gca tct ccc ggc gtg ccc cgc ggc ggg     1784
 Gly Ala Asp Asp Ser Arg Thr Ala Ser Pro Gly Val Pro Arg Gly Gly
     565                 570                 575

 cgc tgg gcc gga gcc gga gcc caa gcc aga gcg gcg cgg cct gga aga     1832
 Arg Trp Ala Gly Ala Gly Ala Gln Ala Arg Ala Ala Arg Pro Gly Arg
 580                 585                 590                 595

 ggc cag ggc ccg ggg gag gcg gcg gca gcg gcg gcg gct ggg gca gcc     1880
 Gly Gln Gly Pro Gly Glu Ala Ala Ala Ala Ala Ala Ala Gly Ala Ala
                 600                 605                 610

 cgg gca gcc cga gcc ccg cag cct ggg cct gtg ctc ggc gcc atg agc     1928
 Arg Ala Ala Arg Ala Pro Gln Pro Gly Pro Val Leu Gly Ala Met Ser
             615                 620                 625

 ggc ggc ggg cct tcg gga ggc ggc cct ggg ggc tcg ggc agg gcg cgg     1976
 Gly Gly Gly Pro Ser Gly Gly Gly Pro Gly Gly Ser Gly Arg Ala Arg
         630                 635                 640

 act agc tcg ttc gcg gag ccc ggc ggc gga ggc gga gga ggc ggc ggc     2024
 Thr Ser Ser Phe Ala Glu Pro Gly Gly Gly Gly Gly Gly Gly Gly Gly
     645                 650                 655

 ggc ccc gga ggc tcg gcc tcc ggc cca ggc ggc acc ggc ggc gga aag     2072
 Gly Pro Gly Gly Ser Ala Ser Gly Pro Gly Gly Thr Gly Gly Gly Lys
 660                 665                 670                 675

 gca tct gtc ggg gcc atg ggt ggg ggc gtc ggg gcc tcg agc tcc ggg     2120
 Ala Ser Val Gly Ala Met Gly Gly Gly Val Gly Ala Ser Ser Ser Gly
                 680                 685                 690

 ggt gga ccc ggc ggc agc ggc gga gga ggc agc gga ggc ccc ggc gca     2168
 Gly Gly Pro Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Pro Gly Ala
             695                 700                 705

 ggc act agc ttc ccg ccg ccc ggg gtg aag ctg ggc cgt gac agc ggg     2216
 Gly Thr Ser Phe Pro Pro Pro Gly Val Lys Leu Gly Arg Asp Ser Gly
         710                 715                 720

 aag gtg acc aca gtc gta gcc act cta ggc caa ggc cca gag cgc tcc     2264
 Lys Val Thr Thr Val Val Ala Thr Leu Gly Gln Gly Pro Glu Arg Ser
     725                 730                 735

 caa gaa gtg gct tac acg gac atc aaa gtg att ggc aat ggc tca ttt     2312
 Gln Glu Val Ala Tyr Thr Asp Ile Lys Val Ile Gly Asn Gly Ser Phe
 740                 745                 750                 755

 ggg gtc gtg tac cag gca cgg ctg gca gag acc agg gaa cta gtc gcc     2360
 Gly Val Val Tyr Gln Ala Arg Leu Ala Glu Thr Arg Glu Leu Val Ala
                 760                 765                 770

 atc aag aag gtt ctc cag gac aag agg ttc aag aac cga gag ctg cag     2408
 Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg Glu Leu Gln
             775                 780                 785

 atc atg cgt aag ctg gac cac tgc aat att gtg agg ctg aga tac ttt     2456
 Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu Arg Tyr Phe
         790                 795                 800

 ttc tac tcc agt ggc gag aag aaa gac gag ctt tac cta aat ctg gtg     2504
 Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Leu Tyr Leu Asn Leu Val
     805                 810                 815

 ctg gaa tat gtg ccc gag aca gtg tac cgg gtg gcc cgc cac ttc acc     2552
 Leu Glu Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg His Phe Thr
 820                 825                 830                 835

 aag gcc aag ttg acc atc cct atc ctc tat gtc aag gtg tac atg tac     2600
 Lys Ala Lys Leu Thr Ile Pro Ile Leu Tyr Val Lys Val Tyr Met Tyr
                 840                 845                 850

 cag ctc ttc cgc agc ttg gcc tac atc cac tcc cag ggc gtg tgt cac     2648
 Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Gln Gly Val Cys His
             855                 860                 865

 cgc gac atc aag ccc cag aac ctg ctg gtg gac cct gac act gct gtc     2696
 Arg Asp Ile Lys Pro Gln Asn Leu Leu Val Asp Pro Asp Thr Ala Val
         870                 875                 880

 ctc aag ctc tgc gat ttt ggc ggt gca aag cag ttg gtc cga ggg gag     2744
 Leu Lys Leu Cys Asp Phe Gly Gly Ala Lys Gln Leu Val Arg Gly Glu
     885                 890                 895

 ccc aat gtc tcc tac atc tgt tct cgc tac tac cgg gcc cca gag ctc     2792
 Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala Pro Glu Leu
 900                 905                 910                 915

 atc ttt gga gcc act gat tac acc tca tcc atc gat gtt tgg tca gct     2840
 Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val Trp Ser Ala
                 920                 925                 930

 ggc tgt gta ctg gca gag ctc ctc ttg ggc cag ccc atc ttc cct ggg     2888
 Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile Phe Pro Gly
             935                 940                 945

 gac agt ggg gtg gac cag ctg gtg gag atc atc aag gtg ctg gga aca     2936
 Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val Leu Gly Thr
         950                 955                 960

 cca acc cgg gaa caa atc cga gag atg aac ccc aac tac acg gag ttc     2984
 Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr Thr Glu Phe
     965                 970                 975

 aag ttc cct cag att aaa gct cac ccc tgg aca aag gtg ttc aaa tct     3032
 Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val Phe Lys Ser
 980                 985                 990                 995

 cga acg ccg cca gag gcc atc gcg ctc tgc tct agc ctg ctg gag tac     3080
 Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Ser Leu Leu Glu Tyr
                1000                1005                1010

 acc cca tcc tca agg ctc tcc cca cta gag gcc tgt gcg cac agc ttc     3128
 Thr Pro Ser Ser Arg Leu Ser Pro Leu Glu Ala Cys Ala His Ser Phe
            1015                1020                1025

 ttt gat gaa ctg cga tgt ctg gga acc cag ctg cct aac aac cgc cca     3176
 Phe Asp Glu Leu Arg Cys Leu Gly Thr Gln Leu Pro Asn Asn Arg Pro
        1030                1035                1040

 ctt ccc cct ctc ttc aac ttc agt gct ggt gaa ctc tcc atc caa ccg     3224
 Leu Pro Pro Leu Phe Asn Phe Ser Ala Gly Glu Leu Ser Ile Gln Pro
    1045                1050                1055

 tct ctc aac gcc att ctc atc cct cct cac ttg agg tcc cca gcg ggc     3272
 Ser Leu Asn Ala Ile Leu Ile Pro Pro His Leu Arg Ser Pro Ala Gly
1060                1065                1070                1075

 act acc acc ctc acc ccg tcc tca caa gct tta act gag act ccg acc     3320
 Thr Thr Thr Leu Thr Pro Ser Ser Gln Ala Leu Thr Glu Thr Pro Thr
                1080                1085                1090

 agc tca gac tgg cag tcg acc gat gcc aca cct acc ctc act aac tcc     3368
 Ser Ser Asp Trp Gln Ser Thr Asp Ala Thr Pro Thr Leu Thr Asn Ser
            1095                1100                1105

 tcc tga gggccccacc aagcaccctt ccacttccat ctgggagccc caagaggggc      3424
 Ser 






      <210> 307
      <211> 620
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(533)

      <220>
      <221> misc_feature
      <222> (1)...(620)
      <223> n = a,t,c or g

      <400> 307
 gttctggaga gagagcactc cgccgggggt cggtgaagta tcccaag  atg gct ggg      56
                                                      Met Ala Gly
                                                        1

 cgt aaa ctt gct cta aaa acc att gat tgg gta tct ttt gtg gag gtc      104
 Arg Lys Leu Ala Leu Lys Thr Ile Asp Trp Val Ser Phe Val Glu Val
       5                  10                  15

 atg ccc caa aac cag aag gca att gga aat gcc ctg aag tcc tgg aat      152
 Met Pro Gln Asn Gln Lys Ala Ile Gly Asn Ala Leu Lys Ser Trp Asn
  20                  25                  30                  35

 gag acc ttc cac gcc agg ttg gct agt ctg tct gag aaa cca cct gcg      200
 Glu Thr Phe His Ala Arg Leu Ala Ser Leu Ser Glu Lys Pro Pro Ala
                  40                  45                  50

 att gac tgg gct tac tac agg gcc aat gtg gcc aag cct ggc ttg gtg      248
 Ile Asp Trp Ala Tyr Tyr Arg Ala Asn Val Ala Lys Pro Gly Leu Val
              55                  60                  65

 gat gat ttt gaa aag aag tat aat gcc ctg aag att cct gtg cct gag      296
 Asp Asp Phe Glu Lys Lys Tyr Asn Ala Leu Lys Ile Pro Val Pro Glu
          70                  75                  80

 gat aaa tac aca gcc ctg gtg gac cag gag gag aag gag gat gtg aag      344
 Asp Lys Tyr Thr Ala Leu Val Asp Gln Glu Glu Lys Glu Asp Val Lys
      85                  90                  95

 agc tgt gct gag ttt gtg tct gga tcc cag ctc agg atc cag gag tat      392
 Ser Cys Ala Glu Phe Val Ser Gly Ser Gln Leu Arg Ile Gln Glu Tyr
 100                 105                 110                 115

 gag aag cag ctg gag aaa atg agg aac ata att ccc ttt gac cag atg      440
 Glu Lys Gln Leu Glu Lys Met Arg Asn Ile Ile Pro Phe Asp Gln Met
                 120                 125                 130

 acc att gat gac ttg aat gag atc ttc cca gaa acc aag ctg gac aaa      488
 Thr Ile Asp Asp Leu Asn Glu Ile Phe Pro Glu Thr Lys Leu Asp Lys
             135                 140                 145

 aag aag tac ccg tac tgg ccc cac cag ccc atc gag aac ctg tga agc      536
 Lys Lys Tyr Pro Tyr Trp Pro His Gln Pro Ile Glu Asn Leu 
         150                 155                 160

 agctgggacg gagccccggc cgacatgaaa taaaacttta aaaaggaacg aaacaaaaaa    596

 aaanaaacnc gaaaaggggc ccgg                                           620




      <210> 308
      <211> 2205
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1401)..(2162)

      <400> 308
 ttaacatgct tcatctgaac tcatcatcat catcacatca acattttcaa gtggatggga     60

 cagatctatg agcctcagat agatcacact ccataatgaa tctccagcat ttggaatggt    120

 gctgggcata cagaaggcac tagaccaatt tttgttgtag gaagagatga tgaaaagttt    180

 aaaggtttcc tgcttatgag catggtcata agaattaata tgattgtcaa actcctggtg    240

 tttgtgatac tgcttgtcac ataattcaca gtaaaagttt gcctttacat cttccagggc    300

 ctttgctgtg gacttctttt ctgcaaaatc cggagaggga gatccgttct tgcacagggg    360

 tcccctgaag actcctttaa tgccccggta gtgcccattg ctgagatgtc tcgaactgat    420

 gaccaggtaa caagccatgt gggtccgggc ggaggcgcag agtctcaact cctcaccagg    480

 cgaccagccg tggaaagcgg gcgggtttct cagcggcaac agcgactacc acctcccgag    540

 aagacgcggc cagcagacgc agggggaggc ggtggcagcg cgtccctgct ccgcgccccg    600

 tgcggggctc ctgctgccga cagctgctgc tctgacagag gcggcggcgg cgacagcaca    660

 gagcacggag gggacccggc gagccagtcc acatgctgct ctgacgagtg tgaagatcca    720

 gcagcagccg ccgtcaccgc cgctgtcttt gtggggagag tggcggggag tccttgggag    780

 cgccaaagcg ctgcccccgc tgtactcggg agagggcgga cgaggagact ggcggctggg    840

 agctgtgggc tcggggctgc ccaggaggct caggtgtgct gggaggactg gggaggctgt    900

 ggtggaggag atgggcagga ggagggcgtt ttctttactc tttcgttgcc tgctggcctt    960

 cagcttttct tcagcgctct ggctgacggc ggcgttggca gaagcaacag ctccccagcc   1020

 ggttgcaaga atgagctgag tgggccctga atgcaacgaa gtgtccttgt aagagaaagg   1080

 agaagacacg cggaagaaga gccacatgaa cacggaagcg gaaatcagtg atgcagccac   1140

 aagccaagga gaatcaaaga acgcgtatgc ccgagggaag gcagaacaca ggacagctga   1200

 gaacaccaga ggactggcag ttgggagcct gatggaggac aagtagggcc tcgaggacag   1260

 gtgcgtgaca gaagcacagg aaaaaaaaga aaaatgaaga aataaaaaca cgagttcatc   1320

 agtaaagagg taccctggca gcataaatat tatgataagc taaaagctgg aatcatctgg   1380

 aaaaataaat aagactcctc    atg tcc ttt tcg gtc cat aac cag aag ggc    1430
                          Met Ser Phe Ser Val His Asn Gln Lys Gly
                            1               5                  10

 agc aaa agg cct ttg cca ctg gaa cct ctt ctt ttt ctc caa gtc cca     1478
 Ser Lys Arg Pro Leu Pro Leu Glu Pro Leu Leu Phe Leu Gln Val Pro
                  15                  20                  25

 cgt agc aat tac ctg cac ttt caa gaa gag aaa caa cga cta cac cta     1526
 Arg Ser Asn Tyr Leu His Phe Gln Glu Glu Lys Gln Arg Leu His Leu
              30                  35                  40

 aag aaa ttc ctt ctt gat agg atg ttt cta gtg gcc aag ata caa gca     1574
 Lys Lys Phe Leu Leu Asp Arg Met Phe Leu Val Ala Lys Ile Gln Ala
          45                  50                  55

 aat gta gaa aga aaa gat gtt gct gac tac tat gaa caa atg ttt cag     1622
 Asn Val Glu Arg Lys Asp Val Ala Asp Tyr Tyr Glu Gln Met Phe Gln
      60                  65                  70

 tca gtt ttg aaa cat cac cta gga gaa gca gtg aca gga ttg ctg ctc     1670
 Ser Val Leu Lys His His Leu Gly Glu Ala Val Thr Gly Leu Leu Leu
  75                  80                  85                  90

 atc tat ccc act tcc att ctg cat atc ctc gag tcc tcc agc gac act     1718
 Ile Tyr Pro Thr Ser Ile Leu His Ile Leu Glu Ser Ser Ser Asp Thr
                  95                 100                 105

 ctc tac aaa gtt ctt tta gat tat att ggc cat gtc aaa gat gaa aca     1766
 Leu Tyr Lys Val Leu Leu Asp Tyr Ile Gly His Val Lys Asp Glu Thr
             110                 115                 120

 gta ttt ttt att caa caa atg aaa att ata gtc att tct cat aac att     1814
 Val Phe Phe Ile Gln Gln Met Lys Ile Ile Val Ile Ser His Asn Ile
         125                 130                 135

 cca atg agg ctt ttt atg caa tgg cat gtt tca gtg ata aaa gtt cca     1862
 Pro Met Arg Leu Phe Met Gln Trp His Val Ser Val Ile Lys Val Pro
     140                 145                 150

 gtt atg tat ctc gac gat gtg aca cag tca cag tcc cta aag gag gtc     1910
 Val Met Tyr Leu Asp Asp Val Thr Gln Ser Gln Ser Leu Lys Glu Val
 155                 160                 165                 170

 atc aca gat ttt ctc aca caa act cat aaa ctg tca ctc tac ctt tgc     1958
 Ile Thr Asp Phe Leu Thr Gln Thr His Lys Leu Ser Leu Tyr Leu Cys
                 175                 180                 185

 cag act atg aaa gta ggc act aaa gga cca ggc gat aac tta cac caa     2006
 Gln Thr Met Lys Val Gly Thr Lys Gly Pro Gly Asp Asn Leu His Gln
             190                 195                 200

 gtt gca cct gac cta ctc ctc cca gaa caa atc ata aag tac ttg tgc     2054
 Val Ala Pro Asp Leu Leu Leu Pro Glu Gln Ile Ile Lys Tyr Leu Cys
         205                 210                 215

 aaa tcc gaa gaa ttc atg gac ccg gca aca ttt ata aac atg tat aat     2102
 Lys Ser Glu Glu Phe Met Asp Pro Ala Thr Phe Ile Asn Met Tyr Asn
     220                 225                 230

 aga ccc ata cac atc act ctg gat tct gag gtg gta tgg cct gct cct     2150
 Arg Pro Ile His Ile Thr Leu Asp Ser Glu Val Val Trp Pro Ala Pro
 235                 240                 245                 250

 tca cgt ttc tag gat tgagagggat aatgtgccca tgtctcttaa ggagtttgtg     2205
 Ser Arg Phe 






      <210> 309
      <211> 538
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (182)..(538)

      <400> 309
 gcacgagtgt tagcctagct atcggccatt actcttaagc gccatctact ggatcacggc     60

 acaaactacc acactaaaat tatcatgcta attatatatg caagatgtga aaccaggtgc    120

 aagaattcac ccacatatgc ggattctgta cagagccctg gccctctgaa agcatccaga    180

 a    atg aat cca act gac cat act caa ctt acc ccg cag tta aag gaa     226
      Met Asn Pro Thr Asp His Thr Gln Leu Thr Pro Gln Leu Lys Glu
        1               5                  10                  15

 cac caa ccc tat cag atg aga aag aat cag cac aag aac tct ggc aat      274
 His Gln Pro Tyr Gln Met Arg Lys Asn Gln His Lys Asn Ser Gly Asn
                  20                  25                  30

 tca aaa aac cac agt gtc ccc tta cct cca aat gag tcc act agc tcc      322
 Ser Lys Asn His Ser Val Pro Leu Pro Pro Asn Glu Ser Thr Ser Ser
              35                  40                  45

 cca gca atg gtt ctt aac cag tct gaa atg act gaa atg aca gac ata      370
 Pro Ala Met Val Leu Asn Gln Ser Glu Met Thr Glu Met Thr Asp Ile
          50                  55                  60

 gaa ttc aga atc tgg atg gca aag aag ctc att gag att cag aag aaa      418
 Glu Phe Arg Ile Trp Met Ala Lys Lys Leu Ile Glu Ile Gln Lys Lys
      65                  70                  75

 gtt gaa act caa tcc aag gaa tcc aag caa tcc agt aaa atg att caa      466
 Val Glu Thr Gln Ser Lys Glu Ser Lys Gln Ser Ser Lys Met Ile Gln
  80                  85                  90                  95

 ggg ctg aaa gat gaa ata gcc att gtg aga aag aac caa tct gaa ctt      514
 Gly Leu Lys Asp Glu Ile Ala Ile Val Arg Lys Asn Gln Ser Glu Leu
                 100                 105                 110

 cta aag ctg aaa aac tca cta taa                                      538
 Leu Lys Leu Lys Asn Ser Leu 
             115





      <210> 310
      <211> 336
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(249)

      <400> 310
 gtc  atg gag gga gca gga gct gga tcc ggc ttc cgg aag gag ctg gtg      48
      Met Glu Gly Ala Gly Ala Gly Ser Gly Phe Arg Lys Glu Leu Val
        1               5                  10                  15

 agc agg ctg ctg cac ctg cac ttc aag gat gac aag acc aaa gtg agc       96
 Ser Arg Leu Leu His Leu His Phe Lys Asp Asp Lys Thr Lys Val Ser
                  20                  25                  30

 ggg gac gcg ctg cag ctc atg gtg gag ttg ctg aag gtc ttc gtt gtg      144
 Gly Asp Ala Leu Gln Leu Met Val Glu Leu Leu Lys Val Phe Val Val
              35                  40                  45

 gaa gca gca gtc cgc ggc gtg cgg cag gcc cag gca gaa gac gcg ctc      192
 Glu Ala Ala Val Arg Gly Val Arg Gln Ala Gln Ala Glu Asp Ala Leu
          50                  55                  60

 cgt gtg gac gtg gac cag ctg gag aag gtg ctt ccg cag ctg ctc ctg      240
 Arg Val Asp Val Asp Gln Leu Glu Lys Val Leu Pro Gln Leu Leu Leu
      65                  70                  75

 gac ttc tag ggatctc agccgtggct gaggccaccc ccagaggagc ccctggtcca      296
 Asp Phe 
  80

 cagaagcagg ccttgtgttt ccagcggcct ctgataagag                          336




      <210> 311
      <211> 1374
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1374)

      <400> 311
  atg atg gaa agg agg atg gag tgc ggt gcc gtc atc atg aat gga tgt      48
  Met Met Glu Arg Arg Met Glu Cys Gly Ala Val Ile Met Asn Gly Cys
    1               5                  10                  15

 att tat gtc act gga gga tac tcc tac tca aag gga acg tat ctt cag       96
 Ile Tyr Val Thr Gly Gly Tyr Ser Tyr Ser Lys Gly Thr Tyr Leu Gln
              20                  25                  30

 agc att gag aaa tat gat cca gat ctt aat aag tgg gaa ata ata gcc      144
 Ser Ile Glu Lys Tyr Asp Pro Asp Leu Asn Lys Trp Glu Ile Ile Ala
          35                  40                  45

 gca atg gct gaa aat ggt gat aat gaa aag atg gct gcc ctg gag gcc      192
 Ala Met Ala Glu Asn Gly Asp Asn Glu Lys Met Ala Ala Leu Glu Ala
      50                  55                  60

 aaa atc tgt cat caa att gag tat tat ttt ggc gac ttc aat ttg cca      240
 Lys Ile Cys His Gln Ile Glu Tyr Tyr Phe Gly Asp Phe Asn Leu Pro
  65                  70                  75                  80

 cgg gac aag ttt cta aag gaa cag ata aaa ctg gat gaa ggc tgg gta      288
 Arg Asp Lys Phe Leu Lys Glu Gln Ile Lys Leu Asp Glu Gly Trp Val
                  85                  90                  95

 cct ttg gag ata atg ata aaa ttc aac agg ttg aac cgt cta aca aca      336
 Pro Leu Glu Ile Met Ile Lys Phe Asn Arg Leu Asn Arg Leu Thr Thr
             100                 105                 110

 gac ttt aat gta att gtg gaa gca ttg agc aaa tcc aag gca gaa ctc      384
 Asp Phe Asn Val Ile Val Glu Ala Leu Ser Lys Ser Lys Ala Glu Leu
         115                 120                 125

 atg gaa atc agt gaa gat aaa act aaa atc aga agg tct cca agc aaa      432
 Met Glu Ile Ser Glu Asp Lys Thr Lys Ile Arg Arg Ser Pro Ser Lys
     130                 135                 140

 ccc cta cct gaa gtg act gat gag tat aaa aat gat gta aaa aac aga      480
 Pro Leu Pro Glu Val Thr Asp Glu Tyr Lys Asn Asp Val Lys Asn Arg
 145                 150                 155                 160

 tct gtt tat att aaa ggc ttc cca act gat gca act ctt gat gac ata      528
 Ser Val Tyr Ile Lys Gly Phe Pro Thr Asp Ala Thr Leu Asp Asp Ile
                 165                 170                 175

 aaa gaa tgg tta gaa gat aaa ggt caa gta cta aat att cag atg aga      576
 Lys Glu Trp Leu Glu Asp Lys Gly Gln Val Leu Asn Ile Gln Met Arg
             180                 185                 190

 aga aca ttg cat aaa gca ttt aag gga tca att ttt gtt gtg ttt gat      624
 Arg Thr Leu His Lys Ala Phe Lys Gly Ser Ile Phe Val Val Phe Asp
         195                 200                 205

 agc att gaa tct gct aag aaa ttt gta gag acc cct ggc cag aag tac      672
 Ser Ile Glu Ser Ala Lys Lys Phe Val Glu Thr Pro Gly Gln Lys Tyr
     210                 215                 220

 aaa gaa aca gac ctg cta ata ctt ttc aag gac gat tac ttt gcc aaa      720
 Lys Glu Thr Asp Leu Leu Ile Leu Phe Lys Asp Asp Tyr Phe Ala Lys
 225                 230                 235                 240

 aaa aat gaa gaa aga aaa caa aat aaa gtg gaa gct aaa tta aga gct      768
 Lys Asn Glu Glu Arg Lys Gln Asn Lys Val Glu Ala Lys Leu Arg Ala
                 245                 250                 255

 aaa cag gag caa gaa gca aaa caa aag tta gaa gaa gat gct gaa atg      816
 Lys Gln Glu Gln Glu Ala Lys Gln Lys Leu Glu Glu Asp Ala Glu Met
             260                 265                 270

 aaa tct cta gaa gaa aag att gga tgc ttg ctg aaa ttt tcg ggt gat      864
 Lys Ser Leu Glu Glu Lys Ile Gly Cys Leu Leu Lys Phe Ser Gly Asp
         275                 280                 285

 tta gat gat cag acc tgt aga gaa gat tta cac ata ctt ttc tca aat      912
 Leu Asp Asp Gln Thr Cys Arg Glu Asp Leu His Ile Leu Phe Ser Asn
     290                 295                 300

 cat ggt gaa ata aaa tgg ata gac ttc gtc aga gga gca aaa gag ggg      960
 His Gly Glu Ile Lys Trp Ile Asp Phe Val Arg Gly Ala Lys Glu Gly
 305                 310                 315                 320

 ata att cta ttt aaa gaa aaa gcc aag gaa gca ttg ggt aaa gcc aaa     1008
 Ile Ile Leu Phe Lys Glu Lys Ala Lys Glu Ala Leu Gly Lys Ala Lys
                 325                 330                 335

 gat gca aat aat ggt aac cta caa tta agg aac aaa gaa gtg act tgg     1056
 Asp Ala Asn Asn Gly Asn Leu Gln Leu Arg Asn Lys Glu Val Thr Trp
             340                 345                 350

 gaa gta cta gaa gga gag gtg gaa aaa gaa gca ctg aag aaa ata ata     1104
 Glu Val Leu Glu Gly Glu Val Glu Lys Glu Ala Leu Lys Lys Ile Ile
         355                 360                 365

 gaa gac caa caa gaa tcc cta aac aaa tgg aag tca aaa ggt cgt aga     1152
 Glu Asp Gln Gln Glu Ser Leu Asn Lys Trp Lys Ser Lys Gly Arg Arg
     370                 375                 380

 ttt aaa gga aaa gga aag ggt aat aaa gct gcc cag cct ggg tct ggt     1200
 Phe Lys Gly Lys Gly Lys Gly Asn Lys Ala Ala Gln Pro Gly Ser Gly
 385                 390                 395                 400

 aaa gga aaa gta cag ttt cag ggc aag aaa acg aaa ttt gct agt gat     1248
 Lys Gly Lys Val Gln Phe Gln Gly Lys Lys Thr Lys Phe Ala Ser Asp
                 405                 410                 415

 gat gaa cat gat gaa cat gat gaa aat ggt gca act gga cct gtg aaa     1296
 Asp Glu His Asp Glu His Asp Glu Asn Gly Ala Thr Gly Pro Val Lys
             420                 425                 430

 aga gca aga gaa gaa aca gac aaa gaa gaa cct gca tcc aaa caa cag     1344
 Arg Ala Arg Glu Glu Thr Asp Lys Glu Glu Pro Ala Ser Lys Gln Gln
         435                 440                 445

 aaa aca gaa aat ggt gct gga gac cag tag                             1374
 Lys Thr Glu Asn Gly Ala Gly Asp Gln 
     450                 455





      <210> 312
      <211> 918
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (274)..(918)

      <400> 312
 atgagcttaa cccttgttga tttcgtcaaa caacaggagc cgcttttcat taaggcggcc     60

 actgacgagc ggatggtgtg ggcgaaggaa agtcagttcg ccatccagct atttcagaac    120

 aacgactacc tcgcgaaagt tgcattccag aaccagacca gcacacagaa cgcgatcatc    180

 aacgttgcgg ctatcggtat ttcgctaaac ccagctcaga agctggctta cctggttccg    240

 cgtaaagggg ctatttgcct cgacatcagt tac atg ggc ctg atg cac atc gcg     294
                                      Met Gly Leu Met His Ile Ala
                                        1               5

 cag cag tct ggc gcc att aag tgg tgc cag tcg gct att gtt cga aga      342
 Gln Gln Ser Gly Ala Ile Lys Trp Cys Gln Ser Ala Ile Val Arg Arg
          10                  15                  20

 aac gac cag ttc ccc cgc gag ggg ctc gat aag ccg ccg atc cac atc      390
 Asn Asp Gln Phe Pro Arg Glu Gly Leu Asp Lys Pro Pro Ile His Ile
      25                  30                  35

 tac aac gac ttt gat act gaa gag cag cgc ggg gac att gta ggg gcg      438
 Tyr Asn Asp Phe Asp Thr Glu Glu Gln Arg Gly Asp Ile Val Gly Ala
  40                  45                  50                  55

 tat gta acg gta aaa act gac gat ggt gat tac ctt acc cat acg atg      486
 Tyr Val Thr Val Lys Thr Asp Asp Gly Asp Tyr Leu Thr His Thr Met
                  60                  65                  70

 ggc atc gat gcc atc tac tcc atc cgt gac cgg tct gaa gca tgg aag      534
 Gly Ile Asp Ala Ile Tyr Ser Ile Arg Asp Arg Ser Glu Ala Trp Lys
              75                  80                  85

 aag tac aaa tct gac aac agc aag aag tgt cca tgg gtc acc gat gaa      582
 Lys Tyr Lys Ser Asp Asn Ser Lys Lys Cys Pro Trp Val Thr Asp Glu
          90                  95                 100

 gag cag atg atc cta aag acg gtc gtg aag cag gca gca aaa tac tgg      630
 Glu Gln Met Ile Leu Lys Thr Val Val Lys Gln Ala Ala Lys Tyr Trp
     105                 110                 115

 cct cga cgt gag cgc ctg gat gcc gcc atc gac cat gtt aat acc gag      678
 Pro Arg Arg Glu Arg Leu Asp Ala Ala Ile Asp His Val Asn Thr Glu
 120                 125                 130                 135

 ggt gag gaa ggt atc aac ttc tca gca gaa cgc cag cca gaa cgc gat      726
 Gly Glu Glu Gly Ile Asn Phe Ser Ala Glu Arg Gln Pro Glu Arg Asp
                 140                 145                 150

 gta acc cca gca gga gac gaa att atc aag gag att aac gac gtc ctt      774
 Val Thr Pro Ala Gly Asp Glu Ile Ile Lys Glu Ile Asn Asp Val Leu
             155                 160                 165

 atc gca atg gat aag aca tgg gaa gaa aac ctg ctc cca gtc tgt tcg      822
 Ile Ala Met Asp Lys Thr Trp Glu Glu Asn Leu Leu Pro Val Cys Ser
         170                 175                 180

 caa att ttc cgt cgt gat att cgc gat tca tcc gag ctt acc caa gcc      870
 Gln Ile Phe Arg Arg Asp Ile Arg Asp Ser Ser Glu Leu Thr Gln Ala
     185                 190                 195

 gag gca gtt aag gcc tta ggc ttc ctc aag aag aag gcg gca gca tga      918
 Glu Ala Val Lys Ala Leu Gly Phe Leu Lys Lys Lys Ala Ala Ala 
 200                 205                 210





      <210> 313
      <211> 681
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(681)

      <400> 313
  atg aac ctc gaa tca atc gct aaa tac ttt gcg cct aaa tca ccg atg      48
  Met Asn Leu Glu Ser Ile Ala Lys Tyr Phe Ala Pro Lys Ser Pro Met
    1               5                  10                  15

 ttc agt gac tct cct cgc gca acc gca tca gac agt ctc acc ggc act       96
 Phe Ser Asp Ser Pro Arg Ala Thr Ala Ser Asp Ser Leu Thr Gly Thr
              20                  25                  30

 gac gtt atg gcg gcg ctt ggc ctt gct ggc cac aag tgc ggg ttt ggt      144
 Asp Val Met Ala Ala Leu Gly Leu Ala Gly His Lys Cys Gly Phe Gly
          35                  40                  45

 ttc gat ctt tac ctc tcg aaa atc ggc att agc agc cca gat ata gca      192
 Phe Asp Leu Tyr Leu Ser Lys Ile Gly Ile Ser Ser Pro Asp Ile Ala
      50                  55                  60

 ctg gag aga ctc tat gag cag gca cgt aag tta tca ggt aaa ttc aga      240
 Leu Glu Arg Leu Tyr Glu Gln Ala Arg Lys Leu Ser Gly Lys Phe Arg
  65                  70                  75                  80

 gca ctg tct gaa ctc gat gaa tca gct cgg tca ggc gtg ctt aag gtt      288
 Ala Leu Ser Glu Leu Asp Glu Ser Ala Arg Ser Gly Val Leu Lys Val
                  85                  90                  95

 ctc tgc gct ttt gca tac cag gat tat tca aga agt gct gcc agc act      336
 Leu Cys Ala Phe Ala Tyr Gln Asp Tyr Ser Arg Ser Ala Ala Ser Thr
             100                 105                 110

 cga aaa tgt gat tgc tgt gat ggt ggc gga ttt aca gag gcg caa gtg      384
 Arg Lys Cys Asp Cys Cys Asp Gly Gly Gly Phe Thr Glu Ala Gln Val
         115                 120                 125

 ttt acc aac aag gtc tca tac cca tgg ggg aaa ccg cct tac tgg tcg      432
 Phe Thr Asn Lys Val Ser Tyr Pro Trp Gly Lys Pro Pro Tyr Trp Ser
     130                 135                 140

 aaa atg tcg cgt gcc gtt cgc cca agc gac tgg gag agc tgg aca cag      480
 Lys Met Ser Arg Ala Val Arg Pro Ser Asp Trp Glu Ser Trp Thr Gln
 145                 150                 155                 160

 gcg cgt gag gtg gtg cga gtt aag tgc aag ccg tgt aac gga aaa ggc      528
 Ala Arg Glu Val Val Arg Val Lys Cys Lys Pro Cys Asn Gly Lys Gly
                 165                 170                 175

 gtt atc agc aat tcg tgt cgc tgc cat ggc aaa ggt aag gtg ctg gac      576
 Val Ile Ser Asn Ser Cys Arg Cys His Gly Lys Gly Lys Val Leu Asp
             180                 185                 190

 aag gca gaa agc gat cgc cag ggc gtt cca gta atg aaa gcc tgc gac      624
 Lys Ala Glu Ser Asp Arg Gln Gly Val Pro Val Met Lys Ala Cys Asp
         195                 200                 205

 cgc tgc ggt ggt aga ggt tac gcc agg ctt aag ttc tca acg gta ttg      672
 Arg Cys Gly Gly Arg Gly Tyr Ala Arg Leu Lys Phe Ser Thr Val Leu
     210                 215                 220

 agg ggg tga                                                          681
 Arg Gly 
 225





      <210> 314
      <211> 4042
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (106)..(1446)

      <400> 314
 ctcatattga aaagatactc acaggtaatc tgtggaaata attcaatctt tgatcattta     60

 tttcagcaat taataaattt atgagtgcat ttgctttcta tttta    atg tca gcg     114
                                                      Met Ser Ala
                                                        1

 gaa gct ggt ggc ggc tgg tgg gcg acc ggg cgc atc ctc att gca gtg      162
 Glu Ala Gly Gly Gly Trp Trp Ala Thr Gly Arg Ile Leu Ile Ala Val
       5                  10                  15

 cgg cgg ccc tac ctc ggc cct ggc ctg acc ccg gcg gcc ctg ccc gcc      210
 Arg Arg Pro Tyr Leu Gly Pro Gly Leu Thr Pro Ala Ala Leu Pro Ala
  20                  25                  30                  35

 cct ccc tcc agc atc atg gcc agc cca aga acc agg aag gtt ctt aaa      258
 Pro Pro Ser Ser Ile Met Ala Ser Pro Arg Thr Arg Lys Val Leu Lys
                  40                  45                  50

 gaa gtc agg gtg cag gat gag aac aac gtt tgt ttt gag tgt ggc gcg      306
 Glu Val Arg Val Gln Asp Glu Asn Asn Val Cys Phe Glu Cys Gly Ala
              55                  60                  65

 ttc aat cct cag tgg gtc agt gtg acc tac ggc atc tgg atc tgc ctg      354
 Phe Asn Pro Gln Trp Val Ser Val Thr Tyr Gly Ile Trp Ile Cys Leu
          70                  75                  80

 gag tgc tcg ggg aga cac cgc ggg ctt ggg gtt cac ctc agc ttt gtg      402
 Glu Cys Ser Gly Arg His Arg Gly Leu Gly Val His Leu Ser Phe Val
      85                  90                  95

 cgc tct gtt act atg gac aag tgg aag gac att gag ctt gag aag atg      450
 Arg Ser Val Thr Met Asp Lys Trp Lys Asp Ile Glu Leu Glu Lys Met
 100                 105                 110                 115

 aaa gct ggt ggg aat gct aag ttc cga gag ttc ctg gag tct cag gag      498
 Lys Ala Gly Gly Asn Ala Lys Phe Arg Glu Phe Leu Glu Ser Gln Glu
                 120                 125                 130

 gat tac gat cct tgc tgg tcc ttg cag gag aag tac aac agc aga gcc      546
 Asp Tyr Asp Pro Cys Trp Ser Leu Gln Glu Lys Tyr Asn Ser Arg Ala
             135                 140                 145

 gcg gcc ctc ttt agg gat aag gtg gtc gct ctg gcc gaa ggc aga gag      594
 Ala Ala Leu Phe Arg Asp Lys Val Val Ala Leu Ala Glu Gly Arg Glu
         150                 155                 160

 tgg tct ctg gag tca tca cct gcc cag aac tgg acc cca cct cag ccc      642
 Trp Ser Leu Glu Ser Ser Pro Ala Gln Asn Trp Thr Pro Pro Gln Pro
     165                 170                 175

 agg acg ctg ccg tcc atg gtg cac cga gtc tct ggc cag ccg cag agt      690
 Arg Thr Leu Pro Ser Met Val His Arg Val Ser Gly Gln Pro Gln Ser
 180                 185                 190                 195

 gtg acc gcc tcc tcg gac aag gct ttt gaa gac tgg ctg aat gat gac      738
 Val Thr Ala Ser Ser Asp Lys Ala Phe Glu Asp Trp Leu Asn Asp Asp
                 200                 205                 210

 ctc ggc tcc tat caa ggg gcc cag ggg aat cgc tac gtg ggg ttt ggg      786
 Leu Gly Ser Tyr Gln Gly Ala Gln Gly Asn Arg Tyr Val Gly Phe Gly
             215                 220                 225

 aac acg cca ccg cct cag aag aaa gaa gat gac ttc ctc aac aac gcc      834
 Asn Thr Pro Pro Pro Gln Lys Lys Glu Asp Asp Phe Leu Asn Asn Ala
         230                 235                 240

 atg tcc tcc ctg tac tcg ggc tgg agc agc ttc acc act gga gcc agc      882
 Met Ser Ser Leu Tyr Ser Gly Trp Ser Ser Phe Thr Thr Gly Ala Ser
     245                 250                 255

 cgg ttt gcc tcg gca gcc aag gag ggc gct aca aag ttt gga tcc caa      930
 Arg Phe Ala Ser Ala Ala Lys Glu Gly Ala Thr Lys Phe Gly Ser Gln
 260                 265                 270                 275

 gcg agt cag aag gcg tcc gag ctg ggc cac agc ctg aac gag aac gtc      978
 Ala Ser Gln Lys Ala Ser Glu Leu Gly His Ser Leu Asn Glu Asn Val
                 280                 285                 290

 ctc aag cct gcg cag gag aag gtg aag gag gga aag att ttt gat gat     1026
 Leu Lys Pro Ala Gln Glu Lys Val Lys Glu Gly Lys Ile Phe Asp Asp
             295                 300                 305

 gtc tcc agt ggg gtc tct cag ttg gcg tcc aag gtc cag gga gtc ggt     1074
 Val Ser Ser Gly Val Ser Gln Leu Ala Ser Lys Val Gln Gly Val Gly
         310                 315                 320

 agt aag gga tgg cgg gac gtc acc acc ttt ttt tcg ggg aaa gca gag     1122
 Ser Lys Gly Trp Arg Asp Val Thr Thr Phe Phe Ser Gly Lys Ala Glu
     325                 330                 335

 ggc ccc ttg gac agc ccc tcg gag ggc cac agt tat cag aac agc ggt     1170
 Gly Pro Leu Asp Ser Pro Ser Glu Gly His Ser Tyr Gln Asn Ser Gly
 340                 345                 350                 355

 ctg gac cac ttc caa aac agc aac ata gac cag agc ttc tgg gag acc     1218
 Leu Asp His Phe Gln Asn Ser Asn Ile Asp Gln Ser Phe Trp Glu Thr
                 360                 365                 370

 ttt gga agt gct gag ccc acc aag acc cgc aag tcc ccg agc agc gac     1266
 Phe Gly Ser Ala Glu Pro Thr Lys Thr Arg Lys Ser Pro Ser Ser Asp
             375                 380                 385

 agc tgg acg tgc gcg gac acc tcc acc gag agg agg agc tcg gac agc     1314
 Ser Trp Thr Cys Ala Asp Thr Ser Thr Glu Arg Arg Ser Ser Asp Ser
         390                 395                 400

 tgg gag gtg tgg ggc tcg gcc tcc acc aac agg aac agc aac agc gac     1362
 Trp Glu Val Trp Gly Ser Ala Ser Thr Asn Arg Asn Ser Asn Ser Asp
     405                 410                 415

 ggc ggg gag ggc ggg gag ggc acc aag aag gca gtg ccg ccg gcc gtg     1410
 Gly Gly Glu Gly Gly Glu Gly Thr Lys Lys Ala Val Pro Pro Ala Val
 420                 425                 430                 435

 ccc act gat gat ggc tgg gac aac cag aac tgg tag ggcc cactgcgccc     1460
 Pro Thr Asp Asp Gly Trp Asp Asn Gln Asn Trp 
                 440                 445

 ccgtccccag cgcccccggg cgacttcgtg tttgcactct gccctcgtcg ttcctcctcc   1520

 ttccatttga cccaagaatc agcaactgca gtgtgaggac agcgtctcgg gaggcaggac   1580

 cctagggaga cccgggtgtg cgccgcctgc gcgtggggag tcttcggtgc gtgggggcgg   1640

 cttgctgtcc agcctgtgtg ggggccgtcc cgtcccacac tcccctgggc attcttggac   1700

 tcaaggccgg ggctctgcgt ggcttgctgg gaggtgggct gcagcacaga ggcctgtgac   1760

 tgcgttccag cggccagttc actacgcagt atctctgggg cctgggacca gccacgtgcc   1820

 gagctgtcag cgacgtgagg tgtcccttct cgttgagata tttaactttg gttttgctct   1880

 agttctttct ttttgaagag agtgactgga gtggtaaaga tggaaatgct ggaaatgata   1940

 ctggcgctca cgctgccatc cgaccaccct cggctcccga gtccacgcct gcctgggcct   2000

 gtgctgtcag acccgcgtcg gtcgtaaccc tctgtggctc ccctgcatca gcaccgtccc   2060

 accaccaagt tcaccaggtt caccagacac ggcctccaca atagccacac ccacacctga   2120

 gctgttctca gtgctggaac ttgaccatcc tggaacaccc tggaagaaaa aggagcgcag   2180

 ggtgggccct cggccctgat gcaggagggt gcgatagcgg acgtggccag gcaggagggg   2240

 ccgggttcag gagctgagca ggggatgcct gtgcgtggtg cctgggtcta gggaagctcc   2300

 agccccagga tggggctgcc ctgcacaccg gtgcccgcca catgccaacc ctcacctccc   2360

 cgaggactgg atgatgtgct gccacgtgtg actcgtctcc cttgtctgcc ctgtgtgacc   2420

 ctcagtcttg gccagccatg catgcgcccg aagctcgtgc agtttgtacg tgaggtgctc   2480

 tcctccctgc caccatgctc atcactctgg ccttggccat gctccctggt caccccactt   2540

 cccggtcgcc gtctgcagca ctcctggagc agcctgggcc cttcagcccc tgtgctcgtc   2600

 ccaccctagg gactcagcca cttgcagaac aggatgggac cgagatttca gcgagccctc   2660

 ctggcgcccg gtcctccctg tgggcaccag ccctcttggt agctggtgtg gagggccggt   2720

 gtccttggct gccacggagg gatttgatca ccgaagcagc cacctgctgt agttggacct   2780

 gaggtcagag gcggggcatc agaggctcaa ggtgctgaga agccaccggg aaagcagcca   2840

 gcacaaaggg cccaggaagc cagcccccga gagctgagcg tgggggtctt tgagtgtctt   2900

 tctccaagct gagacgtggg cggccgcgtg gtatctcccg agggctgctt ggaccctggt   2960

 gggctgagtg ctccgaggag gggtggactc caccttggac agtgggatgt ggtgttccac   3020

 atgtgcctgt ttccacgcca gcaccttgac ttggcagcat ggagccaagg tctgtccccg   3080

 cccaggaggg tgccttcctc gggggtaggg ggacggccca ctctgcccca gggagtccct   3140

 tttgatggga agtgcagtca gcagcgtgga ggtgtctggg ccaccttcag aaggtggatg   3200

 tggtggccga gaccccgtcc acggagggtg atggcctttc ccttctgcag gtgcgggcag   3260

 gtgggcctgg gaccggtgct ggggcctctc cttgctgtga ctgcgttcca gcggccagtt   3320

 cactacgcag tatctctggg gcctgggacc agccacgtgc cgagctgtca gcgacgtgag   3380

 gtgtcccttc tcgttgagat atttaacttt ggttttgctc tagttctttc tttttgaaga   3440

 gagtgactgg agtggtaaag atggaaatgc tggaaatgat actggcgctg acgctgccat   3500

 ccgaccaccc tcggctcccg agtccacagc ctgcctgggc ctgtgctgtc agacccgcgt   3560

 cggtagtaac ctactgtggc tcccctgcat cagcaccgtc ccaccaccaa gttcaccagg   3620

 ttcaccagac acggcctcca caatagccac acccacacct gagctgttct cagtgctgga   3680

 acttgaccat cctggaactt gacttggcag catggagcca aggtctgtcc ccgcacagga   3740

 gggtgccttc ctcgggggta gggggacggc ccactctgcc ccagggagtc ccttttgatg   3800

 ggaagtgcag tcagcagcgt ggaggtgtct gggccacctt cagaaggtgg atgtggtggc   3860

 cgagaccccg tccacggagg gtgatggcct ttcccttctg caggtgcggg caggtgggcc   3920

 tgggaccggt gctggggcct ctccttgctg tgtgtgaggg cccaggtgga aggcgcggac   3980

 ctgacagcat tccaataaag catacgggaa catgcaaaac tccgaaaaaa aaaaaaaaaa   4040

 aa                                                                  4042




      <210> 315
      <211> 2973
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (488)..(2911)

      <400> 315
 ccttccctcg gcagcagcgg ggaagaacag ccgagcagac caaacagccg gggccgcggg     60

 tgggaggctg ttcccgcagc tcgtggctgg cgttggagaa tgtggagatt ttcccattca    120

 taaaaggaac gtctccgctt gccgccttcc cgtccgccgc acaccgccac atccgcagcg    180

 gggagttggg ccggggcaga aggggggcct cggggtagcc gcccaccgga gccaggggct    240

 gaagcagcga gcgcacagca gcccggccgc tggtcctggg gtggagagga ggcgcgcgct    300

 gcagccggcg gcggcgctgg tgctgattca tcacctaaag ctcctcgcag gccaccgcga    360

 gggcagccga ccggctccgg aatctggccg caggttgaag ccgctggtgc gggaccctcg    420

 ggcaggagtc tcccgagctc cggccattca tccccagcgc agagcagcgc tggcagccgg    480

 cgccgcg  atg gag gaa gag ctg aag tgt ccc gtg tgc ggc tct ctg ttt     529
          Met Glu Glu Glu Leu Lys Cys Pro Val Cys Gly Ser Leu Phe
            1               5                  10

 cgg gag cct atc atc ctg ccc tgt tcc cac aat gtc tgc ctg cct tgc      577
 Arg Glu Pro Ile Ile Leu Pro Cys Ser His Asn Val Cys Leu Pro Cys
  15                  20                  25                  30

 gct cgc acc atc gcg gtg cag acc ccg gac ggt gag cag cac ctg ccc      625
 Ala Arg Thr Ile Ala Val Gln Thr Pro Asp Gly Glu Gln His Leu Pro
                  35                  40                  45

 cag ccg ctc ctg ctt tcc cgg gga tcg ggg ctg cag gcg ggc gcc gcc      673
 Gln Pro Leu Leu Leu Ser Arg Gly Ser Gly Leu Gln Ala Gly Ala Ala
              50                  55                  60

 gcc gct gcc tct ctg gag cac gac gct gcg gct ggc ccg gcc tgc ggc      721
 Ala Ala Ala Ser Leu Glu His Asp Ala Ala Ala Gly Pro Ala Cys Gly
          65                  70                  75

 ggt gca ggc ggg agt gca gct ggc ggc ctc ggc ggc ggt gcg gga ggt      769
 Gly Ala Gly Gly Ser Ala Ala Gly Gly Leu Gly Gly Gly Ala Gly Gly
      80                  85                  90

 ggc gga gac cac gcg gac aag ctc agc ttg tac agc gag aca gac agc      817
 Gly Gly Asp His Ala Asp Lys Leu Ser Leu Tyr Ser Glu Thr Asp Ser
  95                 100                 105                 110

 ggc tac ggg tcc tac acc ccg agc ctc aag tcc ccc aac ggg gtt cgc      865
 Gly Tyr Gly Ser Tyr Thr Pro Ser Leu Lys Ser Pro Asn Gly Val Arg
                 115                 120                 125

 gtg ctg ccc atg gtg ccc gca cca ccc ggc tcc tcg gct gcg gcg gct      913
 Val Leu Pro Met Val Pro Ala Pro Pro Gly Ser Ser Ala Ala Ala Ala
             130                 135                 140

 cgg ggt gcc gcc tgc tcc tcg ctg tcc tcg tct tcg agc tcc atc acg      961
 Arg Gly Ala Ala Cys Ser Ser Leu Ser Ser Ser Ser Ser Ser Ile Thr
         145                 150                 155

 tgc ccg cag tgc cac cgc agc gca tcc ctg gac cac cgc ggc ctg cgc     1009
 Cys Pro Gln Cys His Arg Ser Ala Ser Leu Asp His Arg Gly Leu Arg
     160                 165                 170

 ggc ttc cag cgc aac cgg ctg ctc gag gcc atc gtg cag cgg tac cag     1057
 Gly Phe Gln Arg Asn Arg Leu Leu Glu Ala Ile Val Gln Arg Tyr Gln
 175                 180                 185                 190

 cag ggc cgc ggg gcc gtg ccg ggg acg tct gca gcc gcg gcg gtg gcc     1105
 Gln Gly Arg Gly Ala Val Pro Gly Thr Ser Ala Ala Ala Ala Val Ala
                 195                 200                 205

 atc tgc cag ctg tgc gac cgc acc ccg cca gag cca gca gcc acg ctc     1153
 Ile Cys Gln Leu Cys Asp Arg Thr Pro Pro Glu Pro Ala Ala Thr Leu
             210                 215                 220

 tgc gag cag tgc gac gtc ctc tac tgc tct gcc tgc cag ctc aag tgc     1201
 Cys Glu Gln Cys Asp Val Leu Tyr Cys Ser Ala Cys Gln Leu Lys Cys
         225                 230                 235

 cat cca tcc cgg gga ccc ttc gcc aag cat cgc ctg gtg cag ccg ccg     1249
 His Pro Ser Arg Gly Pro Phe Ala Lys His Arg Leu Val Gln Pro Pro
     240                 245                 250

 ccg ccg ccg ccg ccg ccc gcc gag gca gcc tcc ggg ccc act ggc acc     1297
 Pro Pro Pro Pro Pro Pro Ala Glu Ala Ala Ser Gly Pro Thr Gly Thr
 255                 260                 265                 270

 gcc cag ggc gcc ccc agc gga ggc ggc ggc tgc aag agc ccg gga ggc     1345
 Ala Gln Gly Ala Pro Ser Gly Gly Gly Gly Cys Lys Ser Pro Gly Gly
                 275                 280                 285

 gcg ggg gcg ggg gcg act ggg ggc agc acg gcc cgc aag ttc ccc acg     1393
 Ala Gly Ala Gly Ala Thr Gly Gly Ser Thr Ala Arg Lys Phe Pro Thr
             290                 295                 300

 tgt ccc gag cat gaa atg gag aac tac agc atg tac tgc gtg agc tgt     1441
 Cys Pro Glu His Glu Met Glu Asn Tyr Ser Met Tyr Cys Val Ser Cys
         305                 310                 315

 cga acc ccg gtg tgt tat ctg tgc ctg gag gag ggc cgg cac gcc aag     1489
 Arg Thr Pro Val Cys Tyr Leu Cys Leu Glu Glu Gly Arg His Ala Lys
     320                 325                 330

 cac gag gtg aag ccg ctg ggg gcc atg tgg aag cag cac aag gca caa     1537
 His Glu Val Lys Pro Leu Gly Ala Met Trp Lys Gln His Lys Ala Gln
 335                 340                 345                 350

 cta tct cag gcc tta aat gga gtt tca gat aag gca aag gaa gca aag     1585
 Leu Ser Gln Ala Leu Asn Gly Val Ser Asp Lys Ala Lys Glu Ala Lys
                 355                 360                 365

 gag ttt ctg gtt cag cta aag aac ata ttg cag cag atc cag cac tca     1633
 Glu Phe Leu Val Gln Leu Lys Asn Ile Leu Gln Gln Ile Gln His Ser
             370                 375                 380

 cca gat ttt agc atc ttc ccc cta aaa ctc ttt gct tct tcc caa cca     1681
 Pro Asp Phe Ser Ile Phe Pro Leu Lys Leu Phe Ala Ser Ser Gln Pro
         385                 390                 395

 acc ccc aac ctc tgc cag gaa aac gga ctg gac tac gaa gcc tgc ctc     1729
 Thr Pro Asn Leu Cys Gln Glu Asn Gly Leu Asp Tyr Glu Ala Cys Leu
     400                 405                 410

 gtt gct cag tgt gat gcc ctt gtg gat gct tta act cgt cag aaa gcc     1777
 Val Ala Gln Cys Asp Ala Leu Val Asp Ala Leu Thr Arg Gln Lys Ala
 415                 420                 425                 430

 aag ctg ctc acc aag gtg act aaa gag agg gaa cac aag ttg aag atg     1825
 Lys Leu Leu Thr Lys Val Thr Lys Glu Arg Glu His Lys Leu Lys Met
                 435                 440                 445

 gtt tgg gac cag atc aat cac tgc aca ttg aag ctg cgt cag tcc acc     1873
 Val Trp Asp Gln Ile Asn His Cys Thr Leu Lys Leu Arg Gln Ser Thr
             450                 455                 460

 gga ctg atg gag tac tgc ctg gag gtg atc aag gag aac gac ccc tcc     1921
 Gly Leu Met Glu Tyr Cys Leu Glu Val Ile Lys Glu Asn Asp Pro Ser
         465                 470                 475

 ggg ttc tta cag atc tca gat gct ctg atc aag cgc gtc cag gtg tct     1969
 Gly Phe Leu Gln Ile Ser Asp Ala Leu Ile Lys Arg Val Gln Val Ser
     480                 485                 490

 cag gag cag tgg gtc aaa ggc gcc ctg gag ccg aaa gtg tct gcg gag     2017
 Gln Glu Gln Trp Val Lys Gly Ala Leu Glu Pro Lys Val Ser Ala Glu
 495                 500                 505                 510

 ttt gat ctg act ttg gac agc gag ccg ctg ctg cag gcc atc cac cag     2065
 Phe Asp Leu Thr Leu Asp Ser Glu Pro Leu Leu Gln Ala Ile His Gln
                 515                 520                 525

 ctg gac ttc att cag atg aaa tgt agg gtg cca ccc gtc ccc cta ctg     2113
 Leu Asp Phe Ile Gln Met Lys Cys Arg Val Pro Pro Val Pro Leu Leu
             530                 535                 540

 cag ctg gag aaa tgc tgc acc cgt aac aac agc gtc acg ctg gcc tgg     2161
 Gln Leu Glu Lys Cys Cys Thr Arg Asn Asn Ser Val Thr Leu Ala Trp
         545                 550                 555

 agg atg cca ccc ttc acc cac agc ccc gtg gac ggc tac atc ctg gag     2209
 Arg Met Pro Pro Phe Thr His Ser Pro Val Asp Gly Tyr Ile Leu Glu
     560                 565                 570

 ctg gac gac ggt gcc ggg gga cag ttc cgg gaa gtg tac gtc ggt aag     2257
 Leu Asp Asp Gly Ala Gly Gly Gln Phe Arg Glu Val Tyr Val Gly Lys
 575                 580                 585                 590

 gag act ttg tgt acc atc gac ggt ctt cac ttc aac agc acc tac aac     2305
 Glu Thr Leu Cys Thr Ile Asp Gly Leu His Phe Asn Ser Thr Tyr Asn
                 595                 600                 605

 gcc cga gtc aaa gct ttc aac tct tct ggt gtc ggg cct tac agt aaa     2353
 Ala Arg Val Lys Ala Phe Asn Ser Ser Gly Val Gly Pro Tyr Ser Lys
             610                 615                 620

 act gtc gtc ctg cag aca tcc gat gtg gcc tgg ttc aca ttt gac ccc     2401
 Thr Val Val Leu Gln Thr Ser Asp Val Ala Trp Phe Thr Phe Asp Pro
         625                 630                 635

 aac tct ggg cat cgg gac atc att tta tcc aat gac aac cag aca gcc     2449
 Asn Ser Gly His Arg Asp Ile Ile Leu Ser Asn Asp Asn Gln Thr Ala
     640                 645                 650

 acc tgc agc agc tat gac gac cgg gtg gtg ctg ggc aca gct gcg ttc     2497
 Thr Cys Ser Ser Tyr Asp Asp Arg Val Val Leu Gly Thr Ala Ala Phe
 655                 660                 665                 670

 tcc aag ggc gtg cac tac tgg gag ctg cac gtg gac cgg tac gac aac     2545
 Ser Lys Gly Val His Tyr Trp Glu Leu His Val Asp Arg Tyr Asp Asn
                 675                 680                 685

 cac cca gac ccc gcc ttc ggg gtg gcc agg gcc agc gtg gtc aag gac     2593
 His Pro Asp Pro Ala Phe Gly Val Ala Arg Ala Ser Val Val Lys Asp
             690                 695                 700

 atg atg ctg ggc aag gat gac aag gcc tgg gcc atg tat gtg gac aac     2641
 Met Met Leu Gly Lys Asp Asp Lys Ala Trp Ala Met Tyr Val Asp Asn
         705                 710                 715

 aac cgc agc tgg ttc atg cac tgc aac tcc cac acc aac agg acg gaa     2689
 Asn Arg Ser Trp Phe Met His Cys Asn Ser His Thr Asn Arg Thr Glu
     720                 725                 730

 ggt ggc gtg tgc aag ggg gcc acc gtg ggc gtg ctg ctg gac ctg aat     2737
 Gly Gly Val Cys Lys Gly Ala Thr Val Gly Val Leu Leu Asp Leu Asn
 735                 740                 745                 750

 aag cac act ctc acc ttc ttc atc aac ggg cag cag cag ggc ccc aca     2785
 Lys His Thr Leu Thr Phe Phe Ile Asn Gly Gln Gln Gln Gly Pro Thr
                 755                 760                 765

 gcc ttc agc cac gtg gac ggg gtc ttc atg cca gcc ctc agc ctc aac     2833
 Ala Phe Ser His Val Asp Gly Val Phe Met Pro Ala Leu Ser Leu Asn
             770                 775                 780

 cgc aac gtg cag gtc acc ctg cac aca gga ttg gaa gtg ccg act aac     2881
 Arg Asn Val Gln Val Thr Leu His Thr Gly Leu Glu Val Pro Thr Asn
         785                 790                 795

 ctg ggg cgg cca aag ctg tca ggc aat tag c cccgctccag ctcggcactg     2932
 Leu Gly Arg Pro Lys Leu Ser Gly Asn 
     800                 805

 tgcctgtgac agtgacattc acaggcaaaa cgcccaccat t                       2973




      <210> 316
      <211> 1785
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1731)

      <400> 316
  atg tcc aag agg ggc atg agc agc cgg gcc aag ggg gac aag gca gag      48
  Met Ser Lys Arg Gly Met Ser Ser Arg Ala Lys Gly Asp Lys Ala Glu
    1               5                  10                  15

 gcc ctc gcg gcg ctg cag gcg gcc aac gag gat ctt cga gcc aag ctc       96
 Ala Leu Ala Ala Leu Gln Ala Ala Asn Glu Asp Leu Arg Ala Lys Leu
              20                  25                  30

 aca gac atc cag atc gag ctg cag cag gag aag agc aag gtc agc aaa      144
 Thr Asp Ile Gln Ile Glu Leu Gln Gln Glu Lys Ser Lys Val Ser Lys
          35                  40                  45

 gtg gaa cgc gag aag aac cag gag ctg cgg cag gtg cgc gag cat gag      192
 Val Glu Arg Glu Lys Asn Gln Glu Leu Arg Gln Val Arg Glu His Glu
      50                  55                  60

 cag cat aag acc gcg gtc ttg ctc acg gag ctc aag aca aag ctg cac      240
 Gln His Lys Thr Ala Val Leu Leu Thr Glu Leu Lys Thr Lys Leu His
  65                  70                  75                  80

 gag gag aag atg aag gag cta cag gct gtg cgt gag acg ctg ctg cgg      288
 Glu Glu Lys Met Lys Glu Leu Gln Ala Val Arg Glu Thr Leu Leu Arg
                  85                  90                  95

 cag cat gag gct gag ctg ctc agg gtc atc aag atc aag gac aac gag      336
 Gln His Glu Ala Glu Leu Leu Arg Val Ile Lys Ile Lys Asp Asn Glu
             100                 105                 110

 aac cag cgg ctg cag gca ctg ctc agt gcc ctg cgt gat ggc ggc ccc      384
 Asn Gln Arg Leu Gln Ala Leu Leu Ser Ala Leu Arg Asp Gly Gly Pro
         115                 120                 125

 gaa aag gtc aag acc gtg ctg ctg tcc gag gcc aag gag gag gcc aag      432
 Glu Lys Val Lys Thr Val Leu Leu Ser Glu Ala Lys Glu Glu Ala Lys
     130                 135                 140

 aag ggg ttc gag gtg gag aag gtc aag atg cag cag gag atc tcc gag      480
 Lys Gly Phe Glu Val Glu Lys Val Lys Met Gln Gln Glu Ile Ser Glu
 145                 150                 155                 160

 ctc aag ggc gcc aaa agg cag gtg gag gag gcg ctg acg ctg gtg atc      528
 Leu Lys Gly Ala Lys Arg Gln Val Glu Glu Ala Leu Thr Leu Val Ile
                 165                 170                 175

 caa gcg gac aag atc aag gcc gca gag atc cgc agc gtg tac cac ctg      576
 Gln Ala Asp Lys Ile Lys Ala Ala Glu Ile Arg Ser Val Tyr His Leu
             180                 185                 190

 cac cag gag gag atc acc cgc atc aag aag gag tgc gag cgg gag atc      624
 His Gln Glu Glu Ile Thr Arg Ile Lys Lys Glu Cys Glu Arg Glu Ile
         195                 200                 205

 cgc agg ctg atg gag gag ata aaa ttt aaa gac aga gca gtc ttc gtg      672
 Arg Arg Leu Met Glu Glu Ile Lys Phe Lys Asp Arg Ala Val Phe Val
     210                 215                 220

 ctg gag aga gag tta ggg gtt caa gcc ggg cat gct cag aga ctg cag      720
 Leu Glu Arg Glu Leu Gly Val Gln Ala Gly His Ala Gln Arg Leu Gln
 225                 230                 235                 240

 ctc caa aaa gag gct cta gat gag cag ctg tcc cag gtc cga gag gcc      768
 Leu Gln Lys Glu Ala Leu Asp Glu Gln Leu Ser Gln Val Arg Glu Ala
                 245                 250                 255

 gac cgg cac ccg ggc agc ccc aga cgg gaa ctt cct cat gca gct ggt      816
 Asp Arg His Pro Gly Ser Pro Arg Arg Glu Leu Pro His Ala Ala Gly
             260                 265                 270

 gca gga gac gct tca gac cac tcg gga agc cct gaa cag cag ttg gat      864
 Ala Gly Asp Ala Ser Asp His Ser Gly Ser Pro Glu Gln Gln Leu Asp
         275                 280                 285

 gaa aaa gat gcc cgg cgc ttc cag ctt aaa atc gcg gag tta agt gcg      912
 Glu Lys Asp Ala Arg Arg Phe Gln Leu Lys Ile Ala Glu Leu Ser Ala
     290                 295                 300

 att atc cgc aaa ctg gag gac cgc aac gca ttg ctg tcg gaa gag agg      960
 Ile Ile Arg Lys Leu Glu Asp Arg Asn Ala Leu Leu Ser Glu Glu Arg
 305                 310                 315                 320

 aat gag ctg ttg aag cgc gta aga gaa gct gag agt cag tac aag cct     1008
 Asn Glu Leu Leu Lys Arg Val Arg Glu Ala Glu Ser Gln Tyr Lys Pro
                 325                 330                 335

 ctg ctg gat aaa aac aag cgc ctc agt cgg aag aac gag gat ttg tct     1056
 Leu Leu Asp Lys Asn Lys Arg Leu Ser Arg Lys Asn Glu Asp Leu Ser
             340                 345                 350

 cat gct tta cgc cga atg gaa aac aag tta aaa ttt gtc acc cag gag     1104
 His Ala Leu Arg Arg Met Glu Asn Lys Leu Lys Phe Val Thr Gln Glu
         355                 360                 365

 aac ata gaa atg aga cag aga gct gga atc ata cgg aga ccc agt tcc     1152
 Asn Ile Glu Met Arg Gln Arg Ala Gly Ile Ile Arg Arg Pro Ser Ser
     370                 375                 380

 ttg aat gac ctt gat caa agt cag gat gag aga gaa gtc gat ttc ttg     1200
 Leu Asn Asp Leu Asp Gln Ser Gln Asp Glu Arg Glu Val Asp Phe Leu
 385                 390                 395                 400

 aag ctt cag att gtg gag cag caa aac ctc ata gat gaa ctg tct aag     1248
 Lys Leu Gln Ile Val Glu Gln Gln Asn Leu Ile Asp Glu Leu Ser Lys
                 405                 410                 415

 acc ctt gag acc gcc ggc tac gtg aag agc gtg tta gag cgg gac aag     1296
 Thr Leu Glu Thr Ala Gly Tyr Val Lys Ser Val Leu Glu Arg Asp Lys
             420                 425                 430

 ctg tta aga ttc cgg aag caa aga aag aaa atg gca aaa ctt ccc aag     1344
 Leu Leu Arg Phe Arg Lys Gln Arg Lys Lys Met Ala Lys Leu Pro Lys
         435                 440                 445

 ccg gtg gtt gtg gag acc ttc ttt gga tac gac gaa gag gct tcc ctg     1392
 Pro Val Val Val Glu Thr Phe Phe Gly Tyr Asp Glu Glu Ala Ser Leu
     450                 455                 460

 gaa tcc gat ggc tcc tcc gtc tct tac caa aca gac agg acg gac cag     1440
 Glu Ser Asp Gly Ser Ser Val Ser Tyr Gln Thr Asp Arg Thr Asp Gln
 465                 470                 475                 480

 acc ccg tgc acc ccg gac gat gac ttg gag gag ggc atg gcc aag gag     1488
 Thr Pro Cys Thr Pro Asp Asp Asp Leu Glu Glu Gly Met Ala Lys Glu
                 485                 490                 495

 gag acg gag ctg agg ttc cgg cag ctg acc atg gag tac cag gcc ctg     1536
 Glu Thr Glu Leu Arg Phe Arg Gln Leu Thr Met Glu Tyr Gln Ala Leu
             500                 505                 510

 cag cgt gcc tac gct ttg ttg cag gag cag gtt gga ggg acg ctg gac     1584
 Gln Arg Ala Tyr Ala Leu Leu Gln Glu Gln Val Gly Gly Thr Leu Asp
         515                 520                 525

 gca gag cga gaa gtt aag gtc tac gtg act tcc acc gcg cgt tcc ggc     1632
 Ala Glu Arg Glu Val Lys Val Tyr Val Thr Ser Thr Ala Arg Ser Gly
     530                 535                 540

 ccc ccc tct cct ggt ggt gcc cat gga agc cga tca aaa cca ggg att     1680
 Pro Pro Ser Pro Gly Gly Ala His Gly Ser Arg Ser Lys Pro Gly Ile
 545                 550                 555                 560

 ggg gat ccc ggt gat ggg agt tgg ccc agg cca agc ctc tgt tgt ttc     1728
 Gly Asp Pro Gly Asp Gly Ser Trp Pro Arg Pro Ser Leu Cys Cys Phe
                 565                 570                 575

 tga aaat cttcctccag acaccagtgg cagctactgt gagaaccaag agagaggagg     1785
 






      <210> 317
      <211> 1006
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(756)

      <400> 317
  atg cct cgc ttt gca agc cct ctt tta aga aat gtc att atc aga agt      48
  Met Pro Arg Phe Ala Ser Pro Leu Leu Arg Asn Val Ile Ile Arg Ser
    1               5                  10                  15

 caa ttt gat ggc atc aag agg aag caa tgc ctc caa tat ctg aaa acc       96
 Gln Phe Asp Gly Ile Lys Arg Lys Gln Cys Leu Gln Tyr Leu Lys Thr
              20                  25                  30

 ctg aga aca ctg caa tat gat gga ttt aag acc gta tat ttt ggg gaa      144
 Leu Arg Thr Leu Gln Tyr Asp Gly Phe Lys Thr Val Tyr Phe Gly Glu
          35                  40                  45

 acc aat atc cca gaa agt ctc gta act ggg gaa gat att agt gat gga      192
 Thr Asn Ile Pro Glu Ser Leu Val Thr Gly Glu Asp Ile Ser Asp Gly
      50                  55                  60

 tat ttc ata caa acc cca act tgg tgt att gtg cat gct gcg ggt agt      240
 Tyr Phe Ile Gln Thr Pro Thr Trp Cys Ile Val His Ala Ala Gly Ser
  65                  70                  75                  80

 caa gga tgg gtg cct tgg aaa tat cgg gtg ttc cta aga gac gag ctg      288
 Gln Gly Trp Val Pro Trp Lys Tyr Arg Val Phe Leu Arg Asp Glu Leu
                  85                  90                  95

 tgt atc aaa caa gaa gac agc ctc ttc tct gag ttc tgt gat gtg gtg      336
 Cys Ile Lys Gln Glu Asp Ser Leu Phe Ser Glu Phe Cys Asp Val Val
             100                 105                 110

 agg aag gcc tat gga aag tgt gtc atc gtg gtc aaa gag aga agg cag      384
 Arg Lys Ala Tyr Gly Lys Cys Val Ile Val Val Lys Glu Arg Arg Gln
         115                 120                 125

 cag gaa gag cag agg cca aag gaa gac aga gag gct gag ggc cag ttc      432
 Gln Glu Glu Gln Arg Pro Lys Glu Asp Arg Glu Ala Glu Gly Gln Phe
     130                 135                 140

 tat atc cct aca gtc att agc tta gca agc att atg tgt tgc cca gag      480
 Tyr Ile Pro Thr Val Ile Ser Leu Ala Ser Ile Met Cys Cys Pro Glu
 145                 150                 155                 160

 gtg gcc aag tcc tgt ggc cat gaa cta ctc tct ctg cct tcc cct tgt      528
 Val Ala Lys Ser Cys Gly His Glu Leu Leu Ser Leu Pro Ser Pro Cys
                 165                 170                 175

 aat tat ctg aac cct tta gac tca gcc tgg tct tct ctg aaa tgg ttt      576
 Asn Tyr Leu Asn Pro Leu Asp Ser Ala Trp Ser Ser Leu Lys Trp Phe
             180                 185                 190

 atc atc aat aac aga aac gag ttt tgt ttg cag tcc att gac agt ggc      624
 Ile Ile Asn Asn Arg Asn Glu Phe Cys Leu Gln Ser Ile Asp Ser Gly
         195                 200                 205

 tat tct tac caa tgt ata ctt ttc agc aat tta att agc aaa gga att      672
 Tyr Ser Tyr Gln Cys Ile Leu Phe Ser Asn Leu Ile Ser Lys Gly Ile
     210                 215                 220

 gaa agg ata aac gca agc aag tgg aga aca tta act agc aaa gta cgg      720
 Glu Arg Ile Asn Ala Ser Lys Trp Arg Thr Leu Thr Ser Lys Val Arg
 225                 230                 235                 240

 aga tgg gaa aac tac tat ctt ggg aaa ttt tct taa gggt ggttcctcca      770
 Arg Trp Glu Asn Tyr Tyr Leu Gly Lys Phe Ser 
                 245                 250

 acaagcagtg aggctgctac atgtctggtc tttaccgtca actctgttga gatgaattcc    830

 acaccactgc agccaaagat acttcaacag cgacctcaca tggggtgctg cgagaactgg    890

 gttgctccta aggatgttgg caaagcgctt tgagtttact agaagtttca ttaaaatttg    950

 ttggtaagtt ggggtctcga ctcttatctt gtatgagctt ttgcctggat cctctg       1006




      <210> 318
      <211> 5152
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (55)..(5109)

      <400> 318
 cagaagtgca gcggtggcgg cggctggttg cgggccggcg gcgggctggc ggag  atg      57
                                                              Met
                                                                1

 gag gat ctt gtt caa gat ggg gtg gct tca cca gct acc cct ggg acc      105
 Glu Asp Leu Val Gln Asp Gly Val Ala Ser Pro Ala Thr Pro Gly Thr
               5                  10                  15

 ggg aaa tct aag ctg gaa aca ttg ccc aaa gaa gac ctc atc aag ttt      153
 Gly Lys Ser Lys Leu Glu Thr Leu Pro Lys Glu Asp Leu Ile Lys Phe
          20                  25                  30

 gcc aag aaa cag atg atg cta ata cag aaa gct aaa tca agg tgt aca      201
 Ala Lys Lys Gln Met Met Leu Ile Gln Lys Ala Lys Ser Arg Cys Thr
      35                  40                  45

 gaa ttg gag aaa gaa att gaa gaa ctc aga tca aaa cct gtt act gaa      249
 Glu Leu Glu Lys Glu Ile Glu Glu Leu Arg Ser Lys Pro Val Thr Glu
  50                  55                  60                  65

 gga act ggt gat att att aag gca tta act gaa cgt ctg gat gct ctt      297
 Gly Thr Gly Asp Ile Ile Lys Ala Leu Thr Glu Arg Leu Asp Ala Leu
                  70                  75                  80

 ctt ctg gaa aaa gca gag act gag caa cag tgt ctt tct ctg aaa aag      345
 Leu Leu Glu Lys Ala Glu Thr Glu Gln Gln Cys Leu Ser Leu Lys Lys
              85                  90                  95

 gaa aat ata aaa atg aag caa gag gtt gag gat tct gta aca aag atg      393
 Glu Asn Ile Lys Met Lys Gln Glu Val Glu Asp Ser Val Thr Lys Met
         100                 105                 110

 gga gat gca cat aag gag ttg gaa caa tca cat ata aac tat gtg aaa      441
 Gly Asp Ala His Lys Glu Leu Glu Gln Ser His Ile Asn Tyr Val Lys
     115                 120                 125

 gaa att gaa aat ttg aaa aat gag ttg atg gca gta cgt tcc aaa tac      489
 Glu Ile Glu Asn Leu Lys Asn Glu Leu Met Ala Val Arg Ser Lys Tyr
 130                 135                 140                 145

 agt gaa gac aaa gct aac tta caa aag cag ctg gaa gaa gca atg aat      537
 Ser Glu Asp Lys Ala Asn Leu Gln Lys Gln Leu Glu Glu Ala Met Asn
                 150                 155                 160

 acg caa tta gaa ctt tca gaa caa ctt aaa ttt cag aac aac tct gaa      585
 Thr Gln Leu Glu Leu Ser Glu Gln Leu Lys Phe Gln Asn Asn Ser Glu
             165                 170                 175

 gat aat gtt aaa aaa cta caa gaa gag att gag aaa att agg cca ggc      633
 Asp Asn Val Lys Lys Leu Gln Glu Glu Ile Glu Lys Ile Arg Pro Gly
         180                 185                 190

 ttt gag gag caa att tta tat ctg caa aag caa tta gac gct acc act      681
 Phe Glu Glu Gln Ile Leu Tyr Leu Gln Lys Gln Leu Asp Ala Thr Thr
     195                 200                 205

 gat gaa aag aag gaa aca gtt act caa ctc caa aat atc att gag gct      729
 Asp Glu Lys Lys Glu Thr Val Thr Gln Leu Gln Asn Ile Ile Glu Ala
 210                 215                 220                 225

 aat tct cag cat tac caa aaa aat att aat agt ttg cag gaa gag ctt      777
 Asn Ser Gln His Tyr Gln Lys Asn Ile Asn Ser Leu Gln Glu Glu Leu
                 230                 235                 240

 tta cag ttg aaa gct ata cac caa gaa gag gtg aaa gag ttg atg tgc      825
 Leu Gln Leu Lys Ala Ile His Gln Glu Glu Val Lys Glu Leu Met Cys
             245                 250                 255

 cag att gaa gca tca gct aag gaa cat gaa gca gag ata aat aag ttg      873
 Gln Ile Glu Ala Ser Ala Lys Glu His Glu Ala Glu Ile Asn Lys Leu
         260                 265                 270

 aac gag cta aaa gag aac tta gta aaa caa tgt gag gca agt gaa aag      921
 Asn Glu Leu Lys Glu Asn Leu Val Lys Gln Cys Glu Ala Ser Glu Lys
     275                 280                 285

 aac atc cag aag aaa tat gaa tgt gag tta gaa aat tta agg aaa gcc      969
 Asn Ile Gln Lys Lys Tyr Glu Cys Glu Leu Glu Asn Leu Arg Lys Ala
 290                 295                 300                 305

 acc tca aat gca aac caa gac aat cag ata tgt tct att ctc ttg caa     1017
 Thr Ser Asn Ala Asn Gln Asp Asn Gln Ile Cys Ser Ile Leu Leu Gln
                 310                 315                 320

 gaa aat aca ttt gta gaa caa gta gta aat gaa aaa gtc aaa cac tta     1065
 Glu Asn Thr Phe Val Glu Gln Val Val Asn Glu Lys Val Lys His Leu
             325                 330                 335

 gaa gat acc tta aaa gaa ctt gaa tct caa cac agt atc tta aaa gat     1113
 Glu Asp Thr Leu Lys Glu Leu Glu Ser Gln His Ser Ile Leu Lys Asp
         340                 345                 350

 gag gta act tat atg aat aat ctt aag tta aaa ctt gaa atg gat gct     1161
 Glu Val Thr Tyr Met Asn Asn Leu Lys Leu Lys Leu Glu Met Asp Ala
     355                 360                 365

 caa cat ata aag gat gag ttt ttt cat gaa cgg gaa gac tta gag ttt     1209
 Gln His Ile Lys Asp Glu Phe Phe His Glu Arg Glu Asp Leu Glu Phe
 370                 375                 380                 385

 aaa att aat gaa tta tta cta gct aaa gaa gaa cag ggc tgt gta att     1257
 Lys Ile Asn Glu Leu Leu Leu Ala Lys Glu Glu Gln Gly Cys Val Ile
                 390                 395                 400

 gaa aaa tta aaa tct gag cta gca ggt tta aat aaa cag ttt tgc tat     1305
 Glu Lys Leu Lys Ser Glu Leu Ala Gly Leu Asn Lys Gln Phe Cys Tyr
             405                 410                 415

 act gta gaa cag cat aac aga gaa gta cag agt ctt aag gaa caa cat     1353
 Thr Val Glu Gln His Asn Arg Glu Val Gln Ser Leu Lys Glu Gln His
         420                 425                 430

 caa aaa gaa ata tca gaa cta aat gag aca ttt ttg tca gat tca gaa     1401
 Gln Lys Glu Ile Ser Glu Leu Asn Glu Thr Phe Leu Ser Asp Ser Glu
     435                 440                 445

 aaa aaa aaa tta aca tta atg ttt gaa ata cag ggt ctt aag gaa cag     1449
 Lys Lys Lys Leu Thr Leu Met Phe Glu Ile Gln Gly Leu Lys Glu Gln
 450                 455                 460                 465

 tgt gaa aac cta cag caa gaa aag caa gaa gca att tta aat tat gag     1497
 Cys Glu Asn Leu Gln Gln Glu Lys Gln Glu Ala Ile Leu Asn Tyr Glu
                 470                 475                 480

 agt tta cga gag att atg gaa att tta caa aca gaa ctg ggg gaa tct     1545
 Ser Leu Arg Glu Ile Met Glu Ile Leu Gln Thr Glu Leu Gly Glu Ser
             485                 490                 495

 gct gga aaa ata agt caa gag ttc gaa tca atg aag caa cag caa gca     1593
 Ala Gly Lys Ile Ser Gln Glu Phe Glu Ser Met Lys Gln Gln Gln Ala
         500                 505                 510

 tct gat gtt cat gaa ctg cag cag aag ctc aga act gct ttt act gaa     1641
 Ser Asp Val His Glu Leu Gln Gln Lys Leu Arg Thr Ala Phe Thr Glu
     515                 520                 525

 aaa gat gcc ctt ctc gaa act gtg aat cgc ctc cag gga gaa aat gaa     1689
 Lys Asp Ala Leu Leu Glu Thr Val Asn Arg Leu Gln Gly Glu Asn Glu
 530                 535                 540                 545

 aag tta cta tct caa caa gaa ttg gta cca gaa ctt gaa aat acc ata     1737
 Lys Leu Leu Ser Gln Gln Glu Leu Val Pro Glu Leu Glu Asn Thr Ile
                 550                 555                 560

 aag aac ctt caa gaa aag aat gga gta tac tta ctt agt ctc agt caa     1785
 Lys Asn Leu Gln Glu Lys Asn Gly Val Tyr Leu Leu Ser Leu Ser Gln
             565                 570                 575

 aga gat acc atg tta aaa gaa tta gaa gga aag ata aat tct ctt act     1833
 Arg Asp Thr Met Leu Lys Glu Leu Glu Gly Lys Ile Asn Ser Leu Thr
         580                 585                 590

 gag gaa aaa gat gat ttt ata aat aaa ctg aaa aat tcc cat gaa gaa     1881
 Glu Glu Lys Asp Asp Phe Ile Asn Lys Leu Lys Asn Ser His Glu Glu
     595                 600                 605

 atg gat aat ttc cat aag aaa tgt gaa agg gaa gaa aga ttg att ctt     1929
 Met Asp Asn Phe His Lys Lys Cys Glu Arg Glu Glu Arg Leu Ile Leu
 610                 615                 620                 625

 gaa ctt ggg aag aaa gta gag caa aca atc cag tac aac agt gaa cta     1977
 Glu Leu Gly Lys Lys Val Glu Gln Thr Ile Gln Tyr Asn Ser Glu Leu
                 630                 635                 640

 gaa caa aag gta aat gaa tta aca gga gga cta gag gag act tta aaa     2025
 Glu Gln Lys Val Asn Glu Leu Thr Gly Gly Leu Glu Glu Thr Leu Lys
             645                 650                 655

 gaa aag gat caa aat gac caa aaa cta gaa aaa ctt atg gtt caa atg     2073
 Glu Lys Asp Gln Asn Asp Gln Lys Leu Glu Lys Leu Met Val Gln Met
         660                 665                 670

 aaa gtt ctc tct gaa gac aaa gaa gta ttg tca gct gaa gtg aag tct     2121
 Lys Val Leu Ser Glu Asp Lys Glu Val Leu Ser Ala Glu Val Lys Ser
     675                 680                 685

 ctt tat gag gaa aac aat aaa ctc agt tca gaa aaa aaa cag ttg agt     2169
 Leu Tyr Glu Glu Asn Asn Lys Leu Ser Ser Glu Lys Lys Gln Leu Ser
 690                 695                 700                 705

 agg gat ttg gag gtt ttt ttg tct caa aaa gaa gat gtt atc ctt aaa     2217
 Arg Asp Leu Glu Val Phe Leu Ser Gln Lys Glu Asp Val Ile Leu Lys
                 710                 715                 720

 gaa cat att act caa tta gaa aag aaa ctt cag tta atg gtt gaa gag     2265
 Glu His Ile Thr Gln Leu Glu Lys Lys Leu Gln Leu Met Val Glu Glu
             725                 730                 735

 caa gat aat tta aat aaa ctg ctt gaa aat gag caa gtt cag aag tta     2313
 Gln Asp Asn Leu Asn Lys Leu Leu Glu Asn Glu Gln Val Gln Lys Leu
         740                 745                 750

 ttt gtt aaa act cag ttg tat ggt ttt ctt aaa gaa atg gga tca gaa     2361
 Phe Val Lys Thr Gln Leu Tyr Gly Phe Leu Lys Glu Met Gly Ser Glu
     755                 760                 765

 gtt tca gaa gac agt gaa gag aaa gat gtt gtt aat gtc cta cag gca     2409
 Val Ser Glu Asp Ser Glu Glu Lys Asp Val Val Asn Val Leu Gln Ala
 770                 775                 780                 785

 gtc ggt gaa tcc ttg gca aaa ata aat gag gaa aaa tgc aac ctg gct     2457
 Val Gly Glu Ser Leu Ala Lys Ile Asn Glu Glu Lys Cys Asn Leu Ala
                 790                 795                 800

 ttt cag cgt gat gaa aaa gta tta gag tta gaa aaa gag att aag tgc     2505
 Phe Gln Arg Asp Glu Lys Val Leu Glu Leu Glu Lys Glu Ile Lys Cys
             805                 810                 815

 ctt caa gaa gag agt gta gtt cag tgt gaa gaa ctt aag tct tta ttg     2553
 Leu Gln Glu Glu Ser Val Val Gln Cys Glu Glu Leu Lys Ser Leu Leu
         820                 825                 830

 aga gac tat gag caa gag aaa gtt ctc tta agg aaa gag tta gaa gaa     2601
 Arg Asp Tyr Glu Gln Glu Lys Val Leu Leu Arg Lys Glu Leu Glu Glu
     835                 840                 845

 ata cag tca gaa aaa gag gcc ctg cag tct gat ctt cta gaa atg aag     2649
 Ile Gln Ser Glu Lys Glu Ala Leu Gln Ser Asp Leu Leu Glu Met Lys
 850                 855                 860                 865

 aat gct aat gaa aaa aca agg ctt gaa aat cag aat ctt tta att caa     2697
 Asn Ala Asn Glu Lys Thr Arg Leu Glu Asn Gln Asn Leu Leu Ile Gln
                 870                 875                 880

 gtt gaa gaa gta tct caa aca tgt agc aaa agt gaa atc cat aat gaa     2745
 Val Glu Glu Val Ser Gln Thr Cys Ser Lys Ser Glu Ile His Asn Glu
             885                 890                 895

 aaa gaa aaa tgt ttt ata aag gaa cat gaa aac cta aag cca cta cta     2793
 Lys Glu Lys Cys Phe Ile Lys Glu His Glu Asn Leu Lys Pro Leu Leu
         900                 905                 910

 gaa caa aaa gaa tta cga gat agg aga gca gag ttg ata cta tta aag     2841
 Glu Gln Lys Glu Leu Arg Asp Arg Arg Ala Glu Leu Ile Leu Leu Lys
     915                 920                 925

 gat tcc tta gca aaa tca cct tct gta aaa aat gat cct ctg tct tca     2889
 Asp Ser Leu Ala Lys Ser Pro Ser Val Lys Asn Asp Pro Leu Ser Ser
 930                 935                 940                 945

 gta aaa gag ttg gaa gaa aaa ata gaa aat ctg gaa aaa gaa tgc aaa     2937
 Val Lys Glu Leu Glu Glu Lys Ile Glu Asn Leu Glu Lys Glu Cys Lys
                 950                 955                 960

 gaa aag gag gag aaa ata aat aag ata aaa tta gtt gcc gta aag gca     2985
 Glu Lys Glu Glu Lys Ile Asn Lys Ile Lys Leu Val Ala Val Lys Ala
             965                 970                 975

 aag aaa gaa cta gat tcc agc aga aaa gag acc cag act gtg aag gaa     3033
 Lys Lys Glu Leu Asp Ser Ser Arg Lys Glu Thr Gln Thr Val Lys Glu
         980                 985                 990

 gaa ctt gaa tct ctt cga tca gaa aag gac cag tta tct gct tcc atg     3081
 Glu Leu Glu Ser Leu Arg Ser Glu Lys Asp Gln Leu Ser Ala Ser Met
     995                1000                1005

 aga gat ctc att caa gga gca gaa agc tat aag aat ctt tta tta gaa     3129
 Arg Asp Leu Ile Gln Gly Ala Glu Ser Tyr Lys Asn Leu Leu Leu Glu
1010                1015                1020                1025

 tat gaa aag cag tca gag caa ctg gat gtg gaa aaa gaa cgt gct aat     3177
 Tyr Glu Lys Gln Ser Glu Gln Leu Asp Val Glu Lys Glu Arg Ala Asn
                1030                1035                1040

 aat ttt gag cat cgt att gaa gac ctt aca aga caa tta aga aat tcg     3225
 Asn Phe Glu His Arg Ile Glu Asp Leu Thr Arg Gln Leu Arg Asn Ser
            1045                1050                1055

 act ttg cag tgt gaa aca ata aat tct gat aat gaa gat ctc ctg gct     3273
 Thr Leu Gln Cys Glu Thr Ile Asn Ser Asp Asn Glu Asp Leu Leu Ala
        1060                1065                1070

 cgt att gag aca tta cag tct aat gcc aaa tta tta gaa gta cag att     3321
 Arg Ile Glu Thr Leu Gln Ser Asn Ala Lys Leu Leu Glu Val Gln Ile
    1075                1080                1085

 tta gaa gtc cag aga gcc aaa gca atg gta gac aaa gaa tta gaa gct     3369
 Leu Glu Val Gln Arg Ala Lys Ala Met Val Asp Lys Glu Leu Glu Ala
1090                1095                1100                1105

 gaa aaa ctt cag aaa gaa cag aag ata aag gaa cat gcc act act gta     3417
 Glu Lys Leu Gln Lys Glu Gln Lys Ile Lys Glu His Ala Thr Thr Val
                1110                1115                1120

 aat gaa ctt gaa gaa ctt cag gta caa ctt caa aag gaa aag aaa cag     3465
 Asn Glu Leu Glu Glu Leu Gln Val Gln Leu Gln Lys Glu Lys Lys Gln
            1125                1130                1135

 ctt cag aaa acc atg caa gaa tta gag ctg gtt aaa aag gat gcc caa     3513
 Leu Gln Lys Thr Met Gln Glu Leu Glu Leu Val Lys Lys Asp Ala Gln
        1140                1145                1150

 caa acc aca ttg atg aat atg gaa ata gct gat tat gaa cgt ttg atg     3561
 Gln Thr Thr Leu Met Asn Met Glu Ile Ala Asp Tyr Glu Arg Leu Met
    1155                1160                1165

 aaa gaa cta aat caa aag tta act aat aaa aac aac aag ata gaa gat     3609
 Lys Glu Leu Asn Gln Lys Leu Thr Asn Lys Asn Asn Lys Ile Glu Asp
1170                1175                1180                1185

 ttg gag caa gaa ata aaa att caa aaa cag aaa caa gaa acc cta caa     3657
 Leu Glu Gln Glu Ile Lys Ile Gln Lys Gln Lys Gln Glu Thr Leu Gln
                1190                1195                1200

 gaa gaa ata act tca tta cag tct tca gta caa caa tat gaa gaa aaa     3705
 Glu Glu Ile Thr Ser Leu Gln Ser Ser Val Gln Gln Tyr Glu Glu Lys
            1205                1210                1215

 aac acc aaa atc aag caa ttg ctt gtg aaa acc aaa aag gaa ctg gca     3753
 Asn Thr Lys Ile Lys Gln Leu Leu Val Lys Thr Lys Lys Glu Leu Ala
        1220                1225                1230

 gat tca aag caa gca gaa act gat cac tta ata ctt caa gca tct tta     3801
 Asp Ser Lys Gln Ala Glu Thr Asp His Leu Ile Leu Gln Ala Ser Leu
    1235                1240                1245

 aaa ggt gag ctg gag gca agc cag cag caa gta gaa gtc tat aaa ata     3849
 Lys Gly Glu Leu Glu Ala Ser Gln Gln Gln Val Glu Val Tyr Lys Ile
1250                1255                1260                1265

 cag ctg gct gaa ata aca tca gag aag cac aaa atc cac gag cac ctg     3897
 Gln Leu Ala Glu Ile Thr Ser Glu Lys His Lys Ile His Glu His Leu
                1270                1275                1280

 aaa acc tct gcg gaa cag cac cag cgt acg cta agt gca tac cag cag     3945
 Lys Thr Ser Ala Glu Gln His Gln Arg Thr Leu Ser Ala Tyr Gln Gln
            1285                1290                1295

 aga gtg aca gca cta cag gaa gag tgc cgt gct gcc aag gca gaa caa     3993
 Arg Val Thr Ala Leu Gln Glu Glu Cys Arg Ala Ala Lys Ala Glu Gln
        1300                1305                1310

 gct act gta acc tct gaa ttc gag agc tac aaa gtc cga gtt cat aat     4041
 Ala Thr Val Thr Ser Glu Phe Glu Ser Tyr Lys Val Arg Val His Asn
    1315                1320                1325

 gtt cta aaa aaa aaa aaa aat aaa tct atg tct cag gct gaa act gag     4089
 Val Leu Lys Lys Lys Lys Asn Lys Ser Met Ser Gln Ala Glu Thr Glu
1330                1335                1340                1345

 ggc gct aaa caa gaa agg gaa cat ctg gaa atg ctg att gac cag cta     4137
 Gly Ala Lys Gln Glu Arg Glu His Leu Glu Met Leu Ile Asp Gln Leu
                1350                1355                1360

 aaa atc aaa tta caa gat agc caa aat aac tta cag att aat gta tct     4185
 Lys Ile Lys Leu Gln Asp Ser Gln Asn Asn Leu Gln Ile Asn Val Ser
            1365                1370                1375

 gaa ctt cag aca ttg cag tct gaa cat gat aca ctg cta gaa agg cac     4233
 Glu Leu Gln Thr Leu Gln Ser Glu His Asp Thr Leu Leu Glu Arg His
        1380                1385                1390

 aac aag atg ctg cag gaa act gtg tcc aaa gag gcg gaa ctc cgg gaa     4281
 Asn Lys Met Leu Gln Glu Thr Val Ser Lys Glu Ala Glu Leu Arg Glu
    1395                1400                1405

 aaa ttg tgt tca ata cag tca gag aac atg atg atg aaa tct gaa cat     4329
 Lys Leu Cys Ser Ile Gln Ser Glu Asn Met Met Met Lys Ser Glu His
1410                1415                1420                1425

 aca cag act gtg agt cag cta aca tcc cag aac gag gtc ctt cga aat     4377
 Thr Gln Thr Val Ser Gln Leu Thr Ser Gln Asn Glu Val Leu Arg Asn
                1430                1435                1440

 agc ttc cga gat caa gtg cga cat ttg cag gaa gaa cac aga aag aca     4425
 Ser Phe Arg Asp Gln Val Arg His Leu Gln Glu Glu His Arg Lys Thr
            1445                1450                1455

 gtg gag aca tta cag cag cag ctc tcc aag atg gaa gca cag ctc ttc     4473
 Val Glu Thr Leu Gln Gln Gln Leu Ser Lys Met Glu Ala Gln Leu Phe
        1460                1465                1470

 cag ctt aag aat gaa ccg acc aca aga agc cca gtt tcc tct caa caa     4521
 Gln Leu Lys Asn Glu Pro Thr Thr Arg Ser Pro Val Ser Ser Gln Gln
    1475                1480                1485

 tct ttg aag aac ctt cga gaa agg aga aac aca gac ctc ccg ctt cta     4569
 Ser Leu Lys Asn Leu Arg Glu Arg Arg Asn Thr Asp Leu Pro Leu Leu
1490                1495                1500                1505

 gac atg cac act gta acc cgg gaa gag gga gaa ggc atg gag aca act     4617
 Asp Met His Thr Val Thr Arg Glu Glu Gly Glu Gly Met Glu Thr Thr
                1510                1515                1520

 gat acg gag tct gtg tct tcc gcc agc aca tac aca cag tct tta gag     4665
 Asp Thr Glu Ser Val Ser Ser Ala Ser Thr Tyr Thr Gln Ser Leu Glu
            1525                1530                1535

 cag ctg ctt aac tct ccc gaa act aaa ctt gag cct cca tta tgg cat     4713
 Gln Leu Leu Asn Ser Pro Glu Thr Lys Leu Glu Pro Pro Leu Trp His
        1540                1545                1550

 gct gaa ttt acc aaa gaa gaa ttg gtt cag aag ctc agt tcc acc aca     4761
 Ala Glu Phe Thr Lys Glu Glu Leu Val Gln Lys Leu Ser Ser Thr Thr
    1555                1560                1565

 aaa agt gca gat cac tta aac ggc ctg ctt cgg gaa aca gaa gca acc     4809
 Lys Ser Ala Asp His Leu Asn Gly Leu Leu Arg Glu Thr Glu Ala Thr
1570                1575                1580                1585

 aat gca att ctt atg gag caa att aag ctt ctc aaa agt gaa ata aga     4857
 Asn Ala Ile Leu Met Glu Gln Ile Lys Leu Leu Lys Ser Glu Ile Arg
                1590                1595                1600

 aga ttg gaa agg aat caa gag cga gag aag tct gca gct aac ctg gaa     4905
 Arg Leu Glu Arg Asn Gln Glu Arg Glu Lys Ser Ala Ala Asn Leu Glu
            1605                1610                1615

 tac ttg aag aac gtc ttg ctg cag ttc att ttc ttg aaa cca ggt agt     4953
 Tyr Leu Lys Asn Val Leu Leu Gln Phe Ile Phe Leu Lys Pro Gly Ser
        1620                1625                1630

 gaa aga gag aga ctt ctt cct gtt ata aat acg atg ttg cag ctc agc     5001
 Glu Arg Glu Arg Leu Leu Pro Val Ile Asn Thr Met Leu Gln Leu Ser
    1635                1640                1645

 cct gaa gaa aag gga aaa ctt gct gcg gtt gct caa ggt gag gaa gaa     5049
 Pro Glu Glu Lys Gly Lys Leu Ala Ala Val Ala Gln Gly Glu Glu Glu
1650                1655                1660                1665

 aat gct tcc cgt tct tct gga tgg gca tcc tat ctt cat agt tgg tct     5097
 Asn Ala Ser Arg Ser Ser Gly Trp Ala Ser Tyr Leu His Ser Trp Ser
                1670                1675                1680

 gga ctt cga tag gtt gatggaagga atatttttat taaccaaata gaatctattt     5152
 Gly Leu Arg 






      <210> 319
      <211> 3087
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (537)..(1895)

      <400> 319
 ctactaaatt cgcggccgcg tcgaccgtag ctgcagcttt ggaggagtaa gcggcgtggt     60

 agcgaaggtc gccgaacccg cctggctagc cggcgagttg agtggcgact cttttgaaac    120

 agatggtcac catgtttaga tattagcagt cccgtatgtg catgtctgca tttgaaaatg    180

 gaagagggaa acaacaatga agaggtaatt cacttgaaca actttcactg ccatcgggga    240

 caagactttg taattttctt ctggaaaacc cagattatcc aaagagagaa gacagaatca    300

 ttataaatcc cagtagcagt ctgctggcca gccaagatga gacaaagttg cctaaaataa    360

 gacttttttg actattctaa attgactcct cttgaccagc actgcttcat ccaagctgct    420

 gacctcctca tggccgactt caaagtgctc agtagtcagg acatcatgtg ggccctgcac    480

 gagctcaaag gacactatgc aatcacccga aaggcctttt ctgatgccat taaaaa        536                                                                 
 atg gca gga gct atc acc aga aac cag tgg aaa agg aag aag aga aaa      584
 Met Ala Gly Ala Ile Thr Arg Asn Gln Trp Lys Arg Lys Lys Arg Lys
   1               5                  10                  15

 caa atg aac cag tat tct tac att gat ttc aag ttt gaa caa ggt gac      632
 Gln Met Asn Gln Tyr Ser Tyr Ile Asp Phe Lys Phe Glu Gln Gly Asp
              20                  25                  30

 ata aaa ata gaa aag agg atg ttc ttt ctt gaa aat aag cga cga cat      680
 Ile Lys Ile Glu Lys Arg Met Phe Phe Leu Glu Asn Lys Arg Arg His
          35                  40                  45

 tgt agg tcc tat gac cga cgt gct ctc ctt cca gct gtg caa caa gag      728
 Cys Arg Ser Tyr Asp Arg Arg Ala Leu Leu Pro Ala Val Gln Gln Glu
      50                  55                  60

 cag gag ttc tat gag cag aaa atc aaa gag atg gca gag cat gaa gac      776
 Gln Glu Phe Tyr Glu Gln Lys Ile Lys Glu Met Ala Glu His Glu Asp
  65                  70                  75                  80

 ttt ttg ctt gcc cta cag atg aat gaa gaa cag tat caa aag gat ggc      824
 Phe Leu Leu Ala Leu Gln Met Asn Glu Glu Gln Tyr Gln Lys Asp Gly
                  85                  90                  95

 cag ctg att gag tgt cgc tgc tgc tat ggg gaa ttt cca ttc gag gag      872
 Gln Leu Ile Glu Cys Arg Cys Cys Tyr Gly Glu Phe Pro Phe Glu Glu
             100                 105                 110

 ctg acg cag tgc gca gat gct cac ttg ttc tgc aaa gag tgt ctc atc      920
 Leu Thr Gln Cys Ala Asp Ala His Leu Phe Cys Lys Glu Cys Leu Ile
         115                 120                 125

 aga tat gcc caa gag gca gtc ttt gga tct gga aag ttg gag ctc agc      968
 Arg Tyr Ala Gln Glu Ala Val Phe Gly Ser Gly Lys Leu Glu Leu Ser
     130                 135                 140

 tgc atg gaa ggc agc tgc acg tgt tcg ttc cca acc agt gag ctg gag     1016
 Cys Met Glu Gly Ser Cys Thr Cys Ser Phe Pro Thr Ser Glu Leu Glu
 145                 150                 155                 160

 aag gtg ctc ccc cag acc atc ctg tat aag tac tat gag cga aaa gcc     1064
 Lys Val Leu Pro Gln Thr Ile Leu Tyr Lys Tyr Tyr Glu Arg Lys Ala
                 165                 170                 175

 gag gag gag gtt gcg gca gcc tac gcc gac gag ctt gtc agg tgc ccg     1112
 Glu Glu Glu Val Ala Ala Ala Tyr Ala Asp Glu Leu Val Arg Cys Pro
             180                 185                 190

 tcc tgt agc ttt ccg gct ctg ttg gac agt gat gtg aag agg ttc agc     1160
 Ser Cys Ser Phe Pro Ala Leu Leu Asp Ser Asp Val Lys Arg Phe Ser
         195                 200                 205

 tgt cct aat cct cac tgc cga aag gaa acc tgt agg aag tgt cag gga     1208
 Cys Pro Asn Pro His Cys Arg Lys Glu Thr Cys Arg Lys Cys Gln Gly
     210                 215                 220

 ctc tgg aaa gaa cat aat ggc ctc acc tgt gaa gag ctg gct gaa aaa     1256
 Leu Trp Lys Glu His Asn Gly Leu Thr Cys Glu Glu Leu Ala Glu Lys
 225                 230                 235                 240

 gac gac atc aag tac cgt acc tct att gaa gaa aaa atg act gct gcc     1304
 Asp Asp Ile Lys Tyr Arg Thr Ser Ile Glu Glu Lys Met Thr Ala Ala
                 245                 250                 255

 cgc att aga aaa tgc cac aag tgt ggg act ggc ctc atc aaa tct gaa     1352
 Arg Ile Arg Lys Cys His Lys Cys Gly Thr Gly Leu Ile Lys Ser Glu
             260                 265                 270

 ggc tgc aac cgc atg tct tgc cgc tgt ggt gcc cag atg tgc tac ctc     1400
 Gly Cys Asn Arg Met Ser Cys Arg Cys Gly Ala Gln Met Cys Tyr Leu
         275                 280                 285

 tgt cga gtt tct att aat gga tat gac cat ttc tgc caa cat ccc cgc     1448
 Cys Arg Val Ser Ile Asn Gly Tyr Asp His Phe Cys Gln His Pro Arg
     290                 295                 300

 tca cca gga gcc cct tgc cag gag tgt tca aga tgc tct ctc tgg acc     1496
 Ser Pro Gly Ala Pro Cys Gln Glu Cys Ser Arg Cys Ser Leu Trp Thr
 305                 310                 315                 320

 gat ccc act gaa gat gat gag aag ctt att gag gaa atc cag aag gag     1544
 Asp Pro Thr Glu Asp Asp Glu Lys Leu Ile Glu Glu Ile Gln Lys Glu
                 325                 330                 335

 gct gaa gag gaa cag aaa aga aag aat gga gag aac acc ttc aaa cgc     1592
 Ala Glu Glu Glu Gln Lys Arg Lys Asn Gly Glu Asn Thr Phe Lys Arg
             340                 345                 350

 att gga ccc ccg ctg gag aag cct gtg gag aag gtg cag agg gtg gag     1640
 Ile Gly Pro Pro Leu Glu Lys Pro Val Glu Lys Val Gln Arg Val Glu
         355                 360                 365

 gcc ctc ccg agg ccc gtt ccg cag aac ctg cca cag cca cag atg cca     1688
 Ala Leu Pro Arg Pro Val Pro Gln Asn Leu Pro Gln Pro Gln Met Pro
     370                 375                 380

 ccc tat gcc ttc gcg cac cca ccc ttc ccc ctg cct ccc gtg cgg cct     1736
 Pro Tyr Ala Phe Ala His Pro Pro Phe Pro Leu Pro Pro Val Arg Pro
 385                 390                 395                 400

 gtg ttc aac aac ttc cca ctc aac atg ggg cct atc cca gcc ccg tac     1784
 Val Phe Asn Asn Phe Pro Leu Asn Met Gly Pro Ile Pro Ala Pro Tyr
                 405                 410                 415

 gtg ccc cct ctg ccc aac gtg cgg gtc aac tat gac ttc ggt ccc atc     1832
 Val Pro Pro Leu Pro Asn Val Arg Val Asn Tyr Asp Phe Gly Pro Ile
             420                 425                 430

 cac atg ccc ctg gag cac aac ctg ccc atg cac ttt ggc ccc cag ccg     1880
 His Met Pro Leu Glu His Asn Leu Pro Met His Phe Gly Pro Gln Pro
         435                 440                 445

 cgg cat cgc ttc tga tggccccgaa tccccattga gcagcacaaa gcccgtttgg     1935
 Arg His Arg Phe 
     450

 ggtaggagtg tggatggaga accctccccc aaggctggtg tctgtaccat tgcatcctaa   1995

 gtcagcttga agggtaggct ggttttcttc ccaccccttt cctagaaggg ctactgctcc   2055

 tggaagagtg gacggatcca taataaagac gtcccaaatg gtggagttcg gagagagctg   2115

 cgatgtgaac tgcccctccc ctcgcatccc ccaggccacc aacggcagtc cttctgcctt   2175

 gtccatggca taggccatag accaggtccc tgctgctcac acctgggcct ctcctcggag   2235

 ccgacccctg ggtagcaagg cagccgagag catctccctg gaggggccca cggttgggcc   2295

 aagggcagag ggggctgcac ctgcgggcct gggaagcatt gctcagggtg gggggctggg   2355

 accatggccc gcagaggcac tgccacagct gtgagggcca agatgctgtc cccccatcca   2415

 aaacccgtgc gccactgcag tgagtgttga gggcacctct cctcccctct tacacctact   2475

 cagatgaggc agcagcagac ccatctcgcg gcgggggttt tgttctgttg ccgcctaact   2535

 ttctcatcct cggtctctgg aaagtcaggc tgagaaatcc tttcccaggc caggccgctg   2595

 cggtacactg gatggttctg aagctggccc attgaaagag cctcttaagg cagctgggac   2655

 agaggcctgg tggccctgct gggcagccca actgctgggg gagacgtttc tgccaccctg   2715

 ggtgatgagc agcttttccc ccctggcttt ctgggggagg agtgggcctc cttagggaga   2775

 caggtgaccc tgggtgccac ccctgccccg tgtgtgcccc gggtgttctc ttacttgcct   2835

 taaaactgga gagaggaatc tagtatttgc acttagcaaa atatttaaaa actgaaaaaa   2895

 atgtgcatga tctgtcactt tgtataaaaa caagaaacga ttagttcatt aaactttttc   2955

 tttaccttct ggtagtaaaa atagataaaa taattccgtt tcaactactg tgtgtaaaaa   3015

 gcctgtatca tatgtaactg ggacttttgt aaataaatgt ttgtgcgctc tgctcaaaaa   3075

 aaaaaaaaaa aa                                                       3087




      <210> 320
      <211> 603
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(603)

      <400> 320
  atg tcg agc cgc ggt ggg aag aag aag tcc acc aag acg tcc agg tct      48
  Met Ser Ser Arg Gly Gly Lys Lys Lys Ser Thr Lys Thr Ser Arg Ser
    1               5                  10                  15

 gcc aaa gca gga gtc atc ttt ccc gtg ggg cgg atg ctg cgg tac atc       96
 Ala Lys Ala Gly Val Ile Phe Pro Val Gly Arg Met Leu Arg Tyr Ile
              20                  25                  30

 aag aaa ggc cac ccc aag tac agg att gga gtg ggg gca ccc gtg tac      144
 Lys Lys Gly His Pro Lys Tyr Arg Ile Gly Val Gly Ala Pro Val Tyr
          35                  40                  45

 atg gcc gcc gtc ctg gaa tac ctg aca gga aac acg ctg gag aag aaa      192
 Met Ala Ala Val Leu Glu Tyr Leu Thr Gly Asn Thr Leu Glu Lys Lys
      50                  55                  60

 ggt ggc aag gag ttt gtg gaa gct gtc ctg gaa ctc cgg aaa aag aac      240
 Gly Gly Lys Glu Phe Val Glu Ala Val Leu Glu Leu Arg Lys Lys Asn
  65                  70                  75                  80

 ggg ccc ttg gaa gta gct gga gct gct gtc agc gca ggc cat ggc ctg      288
 Gly Pro Leu Glu Val Ala Gly Ala Ala Val Ser Ala Gly His Gly Leu
                  85                  90                  95

 cct gcc aag ttt gtg atc cac tgt aat agt cca gtt tgg ggt gca gac      336
 Pro Ala Lys Phe Val Ile His Cys Asn Ser Pro Val Trp Gly Ala Asp
             100                 105                 110

 aag tgt gaa gaa ctt ctg gaa aag aca gtg aaa aac tgc ttg gcc ctg      384
 Lys Cys Glu Glu Leu Leu Glu Lys Thr Val Lys Asn Cys Leu Ala Leu
         115                 120                 125

 gct gat gat aag aag ctg aaa tcc att gca ttt cca tcc atc ggc agc      432
 Ala Asp Asp Lys Lys Leu Lys Ser Ile Ala Phe Pro Ser Ile Gly Ser
     130                 135                 140

 ggc agg aac ggt ttt cca aag cag aca gca gct cag ctg att ctg aag      480
 Gly Arg Asn Gly Phe Pro Lys Gln Thr Ala Ala Gln Leu Ile Leu Lys
 145                 150                 155                 160

 gcc atc tcc agt tac ttc gtg tct aca atg tcc tct tcc atc aaa acg      528
 Ala Ile Ser Ser Tyr Phe Val Ser Thr Met Ser Ser Ser Ile Lys Thr
                 165                 170                 175

 gtg tac ttc gtg ctt ttt gac agc gag agt ata ggc atc tat gtg cag      576
 Val Tyr Phe Val Leu Phe Asp Ser Glu Ser Ile Gly Ile Tyr Val Gln
             180                 185                 190

 gaa atg gcc aag ctg gac gcc aac tag                                  603
 Glu Met Ala Lys Leu Asp Ala Asn 
         195                 200





      <210> 321
      <211> 1857
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1857)

      <400> 321
  atg aaa tct ggt ttt aaa gtt tgt gcc tgt aat aca gtc cgt gat ata      48
  Met Lys Ser Gly Phe Lys Val Cys Ala Cys Asn Thr Val Arg Asp Ile
    1               5                  10                  15

 ctg gaa ggc aga aca att agt gtt caa ttt aac cag cta ttt ctt aga       96
 Leu Glu Gly Arg Thr Ile Ser Val Gln Phe Asn Gln Leu Phe Leu Arg
              20                  25                  30

 cca aat aaa gag aaa ata gac ttt ctt ctt gag gta tgt tca aga tca      144
 Pro Asn Lys Glu Lys Ile Asp Phe Leu Leu Glu Val Cys Ser Arg Ser
          35                  40                  45

 gta aat tta gaa aaa gct tca gag tct ttg aaa gga aac atg gct gct      192
 Val Asn Leu Glu Lys Ala Ser Glu Ser Leu Lys Gly Asn Met Ala Ala
      50                  55                  60

 ttt cta aag aat gtg tgt ctg ggg ttg gaa gat ctg cag tat gtt ttc      240
 Phe Leu Lys Asn Val Cys Leu Gly Leu Glu Asp Leu Gln Tyr Val Phe
  65                  70                  75                  80

 atg att tct tca cat gag ctt ttc att aca ttg ttg aaa gat gaa gaa      288
 Met Ile Ser Ser His Glu Leu Phe Ile Thr Leu Leu Lys Asp Glu Glu
                  85                  90                  95

 cga aag cta ctt gtt gat cag atg agg aag aga tcc cct aga gta aat      336
 Arg Lys Leu Leu Val Asp Gln Met Arg Lys Arg Ser Pro Arg Val Asn
             100                 105                 110

 ctg tgc att aaa cct gta act tca ttt tat gat atc cca gct tca gca      384
 Leu Cys Ile Lys Pro Val Thr Ser Phe Tyr Asp Ile Pro Ala Ser Ala
         115                 120                 125

 agt gtc aac att ggt cag tta gag cat caa ctt ata ttg tca gtg gat      432
 Ser Val Asn Ile Gly Gln Leu Glu His Gln Leu Ile Leu Ser Val Asp
     130                 135                 140

 cct tgg agg att aga caa att tta att gaa tta cat ggt atg act tca      480
 Pro Trp Arg Ile Arg Gln Ile Leu Ile Glu Leu His Gly Met Thr Ser
 145                 150                 155                 160

 gag cgc cag ttc tgg aca gtg tct aat aag tgg gaa gta cct tct gtc      528
 Glu Arg Gln Phe Trp Thr Val Ser Asn Lys Trp Glu Val Pro Ser Val
                 165                 170                 175

 tat agt ggt gtt atc ctg gga att aaa gac aat tta aca aga gat ttg      576
 Tyr Ser Gly Val Ile Leu Gly Ile Lys Asp Asn Leu Thr Arg Asp Leu
             180                 185                 190

 gtt tat att ctt atg gcc aaa ggt ttg cac tgc agt act gtt aag gac      624
 Val Tyr Ile Leu Met Ala Lys Gly Leu His Cys Ser Thr Val Lys Asp
         195                 200                 205

 ttt tcc cat gct aaa cag ctc ttt gct gct tgt ttg gag ttg gta aca      672
 Phe Ser His Ala Lys Gln Leu Phe Ala Ala Cys Leu Glu Leu Val Thr
     210                 215                 220

 gag ttc tca ccg aag ctt cgt cag gtc atg ctg aat gag atg ttg ctt      720
 Glu Phe Ser Pro Lys Leu Arg Gln Val Met Leu Asn Glu Met Leu Leu
 225                 230                 235                 240

 ttg gat att cat aca cac gaa gct ggg aca ggg cag gca gga gag aga      768
 Leu Asp Ile His Thr His Glu Ala Gly Thr Gly Gln Ala Gly Glu Arg
                 245                 250                 255

 ccg cca tcc gac ctt ata agt aga gta cga ggc tat ctg gaa atg agg      816
 Pro Pro Ser Asp Leu Ile Ser Arg Val Arg Gly Tyr Leu Glu Met Arg
             260                 265                 270

 ctt cct gat att cct ctt cgt caa gtt ata gct gag gaa tgt gtt gcc      864
 Leu Pro Asp Ile Pro Leu Arg Gln Val Ile Ala Glu Glu Cys Val Ala
         275                 280                 285

 ttt atg tta aac tgg aga gaa aat gaa tac ctt aca ctc caa gtt cct      912
 Phe Met Leu Asn Trp Arg Glu Asn Glu Tyr Leu Thr Leu Gln Val Pro
     290                 295                 300

 gca ttt ttg ctt cag agt aat cca tat gta aag ctt gga cag ctt tta      960
 Ala Phe Leu Leu Gln Ser Asn Pro Tyr Val Lys Leu Gly Gln Leu Leu
 305                 310                 315                 320

 gca gct aca tgc aaa gaa ctt cca ggc cct aaa gaa agc aga cgg act     1008
 Ala Ala Thr Cys Lys Glu Leu Pro Gly Pro Lys Glu Ser Arg Arg Thr
                 325                 330                 335

 gcc aaa gac ctt tgg gaa gtt gtt gtt caa atc tgt agt gtg tcc agt     1056
 Ala Lys Asp Leu Trp Glu Val Val Val Gln Ile Cys Ser Val Ser Ser
             340                 345                 350

 cag cac aaa cga gga aat gat ggc aga gtt agt tta ata aaa cag agg     1104
 Gln His Lys Arg Gly Asn Asp Gly Arg Val Ser Leu Ile Lys Gln Arg
         355                 360                 365

 gaa tct acg tta ggt atc atg tat cgg agt gaa ctg ctt tct ttt atc     1152
 Glu Ser Thr Leu Gly Ile Met Tyr Arg Ser Glu Leu Leu Ser Phe Ile
     370                 375                 380

 aaa aaa tta cga gaa cca ctc gtt ttg act att att tta tca ctc ttt     1200
 Lys Lys Leu Arg Glu Pro Leu Val Leu Thr Ile Ile Leu Ser Leu Phe
 385                 390                 395                 400

 gtg aaa ctt cac aat gtt cgg gag gac att gtg aat gat att aca gct     1248
 Val Lys Leu His Asn Val Arg Glu Asp Ile Val Asn Asp Ile Thr Ala
                 405                 410                 415

 gaa cac att tct att tgg cca tct tcc att ccc aac ctc cag tct gtg     1296
 Glu His Ile Ser Ile Trp Pro Ser Ser Ile Pro Asn Leu Gln Ser Val
             420                 425                 430

 gac ttt gaa gct gtg gca atc aca gtg aaa gag cta gtt cga tat aca     1344
 Asp Phe Glu Ala Val Ala Ile Thr Val Lys Glu Leu Val Arg Tyr Thr
         435                 440                 445

 ctc agt ata aat cca aat aac cat tct tgg tta att atc cag gca gat     1392
 Leu Ser Ile Asn Pro Asn Asn His Ser Trp Leu Ile Ile Gln Ala Asp
     450                 455                 460

 att tac ttt gca acg aat cag tat tca gca gct ctt cac tat tac ctc     1440
 Ile Tyr Phe Ala Thr Asn Gln Tyr Ser Ala Ala Leu His Tyr Tyr Leu
 465                 470                 475                 480

 cag gca gga gct gtg tgt tct gac ttc ttt aac aag gct gtg ccc cct     1488
 Gln Ala Gly Ala Val Cys Ser Asp Phe Phe Asn Lys Ala Val Pro Pro
                 485                 490                 495

 gat gtt tat aca gac cag gta ata aaa cga atg ata aaa tgt tgt tct     1536
 Asp Val Tyr Thr Asp Gln Val Ile Lys Arg Met Ile Lys Cys Cys Ser
             500                 505                 510

 ttg ctg aat tgc cac aca cag gtg gcc att tta tgt cag ttc ctc aga     1584
 Leu Leu Asn Cys His Thr Gln Val Ala Ile Leu Cys Gln Phe Leu Arg
         515                 520                 525

 gaa att gac tac aaa aca gcg ttt aaa tct ctg caa gaa caa aac agt     1632
 Glu Ile Asp Tyr Lys Thr Ala Phe Lys Ser Leu Gln Glu Gln Asn Ser
     530                 535                 540

 cat gat gct atg gac tcc tac tac gac tac ata tgg gat gtt acc att     1680
 His Asp Ala Met Asp Ser Tyr Tyr Asp Tyr Ile Trp Asp Val Thr Ile
 545                 550                 555                 560

 ttg gaa tac ttg act tat ctt cat cat aaa aga gga gaa aca gat aaa     1728
 Leu Glu Tyr Leu Thr Tyr Leu His His Lys Arg Gly Glu Thr Asp Lys
                 565                 570                 575

 aga caa att gca atc aaa gcc atc ggc cag aca gag ttg aat gca agc     1776
 Arg Gln Ile Ala Ile Lys Ala Ile Gly Gln Thr Glu Leu Asn Ala Ser
             580                 585                 590

 aat cca gaa gaa gtg tta cag ctg gca gcg cag aga agg aaa aaa aag     1824
 Asn Pro Glu Glu Val Leu Gln Leu Ala Ala Gln Arg Arg Lys Lys Lys
         595                 600                 605

 ttt ctc caa gca atg gca aaa ctt tac ttt taa                         1857
 Phe Leu Gln Ala Met Ala Lys Leu Tyr Phe 
     610                 615





      <210> 322
      <211> 3603
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3603)

      <400> 322
  atg agg cac ccc ttc cca gtt cct cct tgt ttt cct ccc atg cca cca      48
  Met Arg His Pro Phe Pro Val Pro Pro Cys Phe Pro Pro Met Pro Pro
    1               5                  10                  15

 cca atg cct tgt cct aat aac ccc cca gtc cct ggg gca cct cct gga       96
 Pro Met Pro Cys Pro Asn Asn Pro Pro Val Pro Gly Ala Pro Pro Gly
              20                  25                  30

 caa ggc act ttc ccc ttc atg atg ccc cct ccc tcc atg cct cat ccc      144
 Gln Gly Thr Phe Pro Phe Met Met Pro Pro Pro Ser Met Pro His Pro
          35                  40                  45

 ccg ccc cct cca gtc atg ccg cag cag gtt aaa tat cag tac cct ccg      192
 Pro Pro Pro Pro Val Met Pro Gln Gln Val Lys Tyr Gln Tyr Pro Pro
      50                  55                  60

 ggc tat tct cac cac aac ttc cca cct ccc agt ttt aat agt ttc cag      240
 Gly Tyr Ser His His Asn Phe Pro Pro Pro Ser Phe Asn Ser Phe Gln
  65                  70                  75                  80

 aac aac cct agt tct ttc ctg ccc agt gct aat aac agc agt agt cct      288
 Asn Asn Pro Ser Ser Phe Leu Pro Ser Ala Asn Asn Ser Ser Ser Pro
                  85                  90                  95

 cat ttc aga cat ctc cct cca tac cca ctc cca aag gct ccc agt gag      336
 His Phe Arg His Leu Pro Pro Tyr Pro Leu Pro Lys Ala Pro Ser Glu
             100                 105                 110

 aga agg tcc cca gaa agg ctg aaa cac tat gat gac cac agg cac cga      384
 Arg Arg Ser Pro Glu Arg Leu Lys His Tyr Asp Asp His Arg His Arg
         115                 120                 125

 gat cac agt cat ggg cga ggt gag agg cat cgg tcc ctg gat cgg cgg      432
 Asp His Ser His Gly Arg Gly Glu Arg His Arg Ser Leu Asp Arg Arg
     130                 135                 140

 gag cga ggc cgc agt ccc gac agg aga aga caa gac agc cgg tac aga      480
 Glu Arg Gly Arg Ser Pro Asp Arg Arg Arg Gln Asp Ser Arg Tyr Arg
 145                 150                 155                 160

 tct gat tat gac cga ggg aga aca cca tct cgc cac cgc agc tac gaa      528
 Ser Asp Tyr Asp Arg Gly Arg Thr Pro Ser Arg His Arg Ser Tyr Glu
                 165                 170                 175

 cgg agc agt cgc tcc cca agt agg gag aag aag aga gct cgt tgg gag      576
 Arg Ser Ser Arg Ser Pro Ser Arg Glu Lys Lys Arg Ala Arg Trp Glu
             180                 185                 190

 gaa gaa aaa gac cgt tgg agt gac aac cag agt tct ggc aaa gac aag      624
 Glu Glu Lys Asp Arg Trp Ser Asp Asn Gln Ser Ser Gly Lys Asp Lys
         195                 200                 205

 aac tat acc tca atc aag gaa aaa gag ccc gag gag acc atg cct gac      672
 Asn Tyr Thr Ser Ile Lys Glu Lys Glu Pro Glu Glu Thr Met Pro Asp
     210                 215                 220

 aag aat gag gag gaa gaa gaa gaa ctt ctt aag cct gtg tgg gtt cga      720
 Lys Asn Glu Glu Glu Glu Glu Glu Leu Leu Lys Pro Val Trp Val Arg
 225                 230                 235                 240

 tgc act cat tca gaa aac tac tac tcc agt gac ccc atg gat cag gtg      768
 Cys Thr His Ser Glu Asn Tyr Tyr Ser Ser Asp Pro Met Asp Gln Val
                 245                 250                 255

 gga gat tct aca gtg gtt gga acg agt agg ctt cgt gac tta tat gac      816
 Gly Asp Ser Thr Val Val Gly Thr Ser Arg Leu Arg Asp Leu Tyr Asp
             260                 265                 270

 aaa ttt gag gag gag ttg ggg agc agg caa gaa aag gcc aaa gct gct      864
 Lys Phe Glu Glu Glu Leu Gly Ser Arg Gln Glu Lys Ala Lys Ala Ala
         275                 280                 285

 cgg cct ccg tgg gaa cct cca aag acg aag ctc gat gaa gat tta gag      912
 Arg Pro Pro Trp Glu Pro Pro Lys Thr Lys Leu Asp Glu Asp Leu Glu
     290                 295                 300

 agt tcc agt gaa tcc gag tgt gag tct gat gag gac agc acc tgt tct      960
 Ser Ser Ser Glu Ser Glu Cys Glu Ser Asp Glu Asp Ser Thr Cys Ser
 305                 310                 315                 320

 agc agc tca gac tct gaa gtt ttt gac gtt att gca gaa atc aaa cgc     1008
 Ser Ser Ser Asp Ser Glu Val Phe Asp Val Ile Ala Glu Ile Lys Arg
                 325                 330                 335

 aaa aag gcc cac cct gac cga ctt cat gat gaa ctt tgg tac aac gat     1056
 Lys Lys Ala His Pro Asp Arg Leu His Asp Glu Leu Trp Tyr Asn Asp
             340                 345                 350

 cca ggc cag atg aat gat gga cca ctc tgc aaa tgc agc gca aag gca     1104
 Pro Gly Gln Met Asn Asp Gly Pro Leu Cys Lys Cys Ser Ala Lys Ala
         355                 360                 365

 aga cgc aca gga att agg cac agc att tat cct gga gaa gag gcc atc     1152
 Arg Arg Thr Gly Ile Arg His Ser Ile Tyr Pro Gly Glu Glu Ala Ile
     370                 375                 380

 aag ccc tgt cgt cct atg acc aac aat gct ggc aga ctt ttc cac tac     1200
 Lys Pro Cys Arg Pro Met Thr Asn Asn Ala Gly Arg Leu Phe His Tyr
 385                 390                 395                 400

 cgg atc aca gtc tcc ccg cct acg aac ttt tta act gac agg cca act     1248
 Arg Ile Thr Val Ser Pro Pro Thr Asn Phe Leu Thr Asp Arg Pro Thr
                 405                 410                 415

 gtt ata gaa tac gat gat cac gag tat atc ttt gaa gga ttt tct atg     1296
 Val Ile Glu Tyr Asp Asp His Glu Tyr Ile Phe Glu Gly Phe Ser Met
             420                 425                 430

 ttt gca cat gcc ccc ctg acc aat att cca ctg tgt aaa gta att aga     1344
 Phe Ala His Ala Pro Leu Thr Asn Ile Pro Leu Cys Lys Val Ile Arg
         435                 440                 445

 ttc aac ata gac tac acg att cat ttc att gaa gag atg atg ccg gag     1392
 Phe Asn Ile Asp Tyr Thr Ile His Phe Ile Glu Glu Met Met Pro Glu
     450                 455                 460

 aat ttt tgt gtg aaa ggg ctt gaa ctc ttt tca ctg ttc cta ttc aga     1440
 Asn Phe Cys Val Lys Gly Leu Glu Leu Phe Ser Leu Phe Leu Phe Arg
 465                 470                 475                 480

 gat att ttg gaa tta tat gac tgg aat ctt aaa ggt cct ttg ttt gaa     1488
 Asp Ile Leu Glu Leu Tyr Asp Trp Asn Leu Lys Gly Pro Leu Phe Glu
                 485                 490                 495

 gac agc cct ccc tgc tgc cca aga ttt cat ttc atg cca cgt ttt gta     1536
 Asp Ser Pro Pro Cys Cys Pro Arg Phe His Phe Met Pro Arg Phe Val
             500                 505                 510

 aga ttt ctt cca gat gga gga aag gaa gtg ctg tcc atg cac cag att     1584
 Arg Phe Leu Pro Asp Gly Gly Lys Glu Val Leu Ser Met His Gln Ile
         515                 520                 525

 ctc ctg tac ttg tta agg tgc agc aaa gcc ctg gtg cct gag gag gag     1632
 Leu Leu Tyr Leu Leu Arg Cys Ser Lys Ala Leu Val Pro Glu Glu Glu
     530                 535                 540

 att gcc aat atg ctt cag tgg gag gag ctg gag tgg cag aaa tat gca     1680
 Ile Ala Asn Met Leu Gln Trp Glu Glu Leu Glu Trp Gln Lys Tyr Ala
 545                 550                 555                 560

 gaa gaa tgc aaa ggc atg att gtt acc aac cct ggg acg aaa cca agc     1728
 Glu Glu Cys Lys Gly Met Ile Val Thr Asn Pro Gly Thr Lys Pro Ser
                 565                 570                 575

 tct gtc cgt atc gat caa ctg gat cgt gaa cag ttc aac ccc gat gtg     1776
 Ser Val Arg Ile Asp Gln Leu Asp Arg Glu Gln Phe Asn Pro Asp Val
             580                 585                 590

 att act ttt ccg att atc gtc cac ttt ggg ata cgc cct gca cag ttg     1824
 Ile Thr Phe Pro Ile Ile Val His Phe Gly Ile Arg Pro Ala Gln Leu
         595                 600                 605

 agt tat gca gga gac cca cag tac caa aaa ctg tgg aag agt tat gtg     1872
 Ser Tyr Ala Gly Asp Pro Gln Tyr Gln Lys Leu Trp Lys Ser Tyr Val
     610                 615                 620

 aaa ctt cgc cac ctc cta gca aat agt ccc aaa gtc aaa caa act gac     1920
 Lys Leu Arg His Leu Leu Ala Asn Ser Pro Lys Val Lys Gln Thr Asp
 625                 630                 635                 640

 aaa cag aag ctg gca cag agg gag gaa gcc ctc caa aaa ata cgg cag     1968
 Lys Gln Lys Leu Ala Gln Arg Glu Glu Ala Leu Gln Lys Ile Arg Gln
                 645                 650                 655

 aag aat aca atg aga cga gaa gta acg gtg gag cta agt agc caa gga     2016
 Lys Asn Thr Met Arg Arg Glu Val Thr Val Glu Leu Ser Ser Gln Gly
             660                 665                 670

 ttc tgg aaa act ggc atc cgt tct gat gtc tgt cag cat gca atg atg     2064
 Phe Trp Lys Thr Gly Ile Arg Ser Asp Val Cys Gln His Ala Met Met
         675                 680                 685

 cta cct gtt ctg acc cat cat atc cgc tac cac caa tgc cta atg cat     2112
 Leu Pro Val Leu Thr His His Ile Arg Tyr His Gln Cys Leu Met His
     690                 695                 700

 ttg gac aag ttg ata gga tat act ttc caa gat cgt tgt ctg ttg cag     2160
 Leu Asp Lys Leu Ile Gly Tyr Thr Phe Gln Asp Arg Cys Leu Leu Gln
 705                 710                 715                 720

 ctg gcc atg act cat cca agt cat cat tta aat ttt gga atg aat cct     2208
 Leu Ala Met Thr His Pro Ser His His Leu Asn Phe Gly Met Asn Pro
                 725                 730                 735

 gat cat gcc agg aat tca tta tct aac tgt gga att cgg cag ccc aaa     2256
 Asp His Ala Arg Asn Ser Leu Ser Asn Cys Gly Ile Arg Gln Pro Lys
             740                 745                 750

 tac gga gac aga aaa gtt cat cac atg cac atg cgg aag aaa ggg att     2304
 Tyr Gly Asp Arg Lys Val His His Met His Met Arg Lys Lys Gly Ile
         755                 760                 765

 aac acc ttg ata aat atc atg tca cgc ctt ggc caa gat gac cca act     2352
 Asn Thr Leu Ile Asn Ile Met Ser Arg Leu Gly Gln Asp Asp Pro Thr
     770                 775                 780

 ccc tcg agg att aac cac aat gaa cgg ttg gaa ttc ctg ggt gat gct     2400
 Pro Ser Arg Ile Asn His Asn Glu Arg Leu Glu Phe Leu Gly Asp Ala
 785                 790                 795                 800

 gtt gtt gaa ttt ctg acc agc gtc cat ttg tac tat ttg ttt cct agt     2448
 Val Val Glu Phe Leu Thr Ser Val His Leu Tyr Tyr Leu Phe Pro Ser
                 805                 810                 815

 ctg gaa gaa gga gga tta gca acc tat cgg act gcc att gtt cag aat     2496
 Leu Glu Glu Gly Gly Leu Ala Thr Tyr Arg Thr Ala Ile Val Gln Asn
             820                 825                 830

 cag cac ctt gcc atg cta gca aag aaa ctt gaa ctg gat cga ttt atg     2544
 Gln His Leu Ala Met Leu Ala Lys Lys Leu Glu Leu Asp Arg Phe Met
         835                 840                 845

 ctg tat gct cac ggg cct gac ctt tgt aga gaa tcg gac ctt cga cat     2592
 Leu Tyr Ala His Gly Pro Asp Leu Cys Arg Glu Ser Asp Leu Arg His
     850                 855                 860

 gca atg gcc aat tgt ttt gaa gcg tta ata gga gct gtt tac ttg gag     2640
 Ala Met Ala Asn Cys Phe Glu Ala Leu Ile Gly Ala Val Tyr Leu Glu
 865                 870                 875                 880

 gga agc ctg gag gaa gcc aag cag tta ttt gga cgc ttg ctc ttt aat     2688
 Gly Ser Leu Glu Glu Ala Lys Gln Leu Phe Gly Arg Leu Leu Phe Asn
                 885                 890                 895

 gat ccg gac ctg cgc gaa gtc tgg ctc aat tat cct ctc cac cca ctc     2736
 Asp Pro Asp Leu Arg Glu Val Trp Leu Asn Tyr Pro Leu His Pro Leu
             900                 905                 910

 caa cta caa gag cca aat act gat cga caa ctt att gaa act tct ccg     2784
 Gln Leu Gln Glu Pro Asn Thr Asp Arg Gln Leu Ile Glu Thr Ser Pro
         915                 920                 925

 gtt cta caa aaa ctt act gag ttt gaa gaa gca att gga gta att ttt     2832
 Val Leu Gln Lys Leu Thr Glu Phe Glu Glu Ala Ile Gly Val Ile Phe
     930                 935                 940

 act cat gtt cga ctt ctg gca agg gca ttc aca ttg aga act gtg gga     2880
 Thr His Val Arg Leu Leu Ala Arg Ala Phe Thr Leu Arg Thr Val Gly
 945                 950                 955                 960

 ttt aac cat ctg acc cta ggc cac aat cag aga atg gaa ttc cta ggt     2928
 Phe Asn His Leu Thr Leu Gly His Asn Gln Arg Met Glu Phe Leu Gly
                 965                 970                 975

 gac tcc ata atg caa ctg gta gcc aca gag tac tta ttc att cat ttc     2976
 Asp Ser Ile Met Gln Leu Val Ala Thr Glu Tyr Leu Phe Ile His Phe
             980                 985                 990

 cca gat cat cat gaa gga cac tta act ttg ttg cga agc tct ttg gtg     3024
 Pro Asp His His Glu Gly His Leu Thr Leu Leu Arg Ser Ser Leu Val
         995                1000                1005

 aat aat aga act cag gcc aag gta gcg gag gag ctg ggc atg cag gag     3072
 Asn Asn Arg Thr Gln Ala Lys Val Ala Glu Glu Leu Gly Met Gln Glu
    1010                1015                1020

 tac gcc ata acc aac gac aag acc aag agg cct gtg gcg ctt cgc acc     3120
 Tyr Ala Ile Thr Asn Asp Lys Thr Lys Arg Pro Val Ala Leu Arg Thr
1025                1030                1035                1040

 aag acc ttg gcg gac ctt ttg gaa tca ttt att gca gcg ctg tac att     3168
 Lys Thr Leu Ala Asp Leu Leu Glu Ser Phe Ile Ala Ala Leu Tyr Ile
                1045                1050                1055

 gat aag gat ttg gaa tat gtt cat act ttc atg aat gtc tgc ttc ttt     3216
 Asp Lys Asp Leu Glu Tyr Val His Thr Phe Met Asn Val Cys Phe Phe
            1060                1065                1070

 cca cga ttg aaa gag ttc att ttg aac cag gat tgg aat gac ccc aaa     3264
 Pro Arg Leu Lys Glu Phe Ile Leu Asn Gln Asp Trp Asn Asp Pro Lys
        1075                1080                1085

 tcc cag ctt cag cag tgt tgc ttg aca ctt agg aca gaa gga aaa gag     3312
 Ser Gln Leu Gln Gln Cys Cys Leu Thr Leu Arg Thr Glu Gly Lys Glu
    1090                1095                1100

 cca gac att cct ctg tac aag act ctg cag aca gtg ggc cca tcc cat     3360
 Pro Asp Ile Pro Leu Tyr Lys Thr Leu Gln Thr Val Gly Pro Ser His
1105                1110                1115                1120

 gcc cga acc tac act gtg gct gtt tat ttc aag gga gaa aga ata ggc     3408
 Ala Arg Thr Tyr Thr Val Ala Val Tyr Phe Lys Gly Glu Arg Ile Gly
                1125                1130                1135

 tgt ggg aaa gga cca agt att cag caa gcg gaa atg gga gca gca atg     3456
 Cys Gly Lys Gly Pro Ser Ile Gln Gln Ala Glu Met Gly Ala Ala Met
            1140                1145                1150

 gat gcg ctt gaa aaa tat aat ttt ccc cag atg gcc cat cag aag cgg     3504
 Asp Ala Leu Glu Lys Tyr Asn Phe Pro Gln Met Ala His Gln Lys Arg
        1155                1160                1165

 ttc atc gaa cgg aag tac aga caa gag tta aaa gaa atg agg tgg gaa     3552
 Phe Ile Glu Arg Lys Tyr Arg Gln Glu Leu Lys Glu Met Arg Trp Glu
    1170                1175                1180

 aga gag cat caa gag aga gag cca gat gag act gaa gac atc aag aaa     3600
 Arg Glu His Gln Glu Arg Glu Pro Asp Glu Thr Glu Asp Ile Lys Lys
1185                1190                1195                1200

 taa                                                                 3603
 






      <210> 323
      <211> 531
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(531)

      <400> 323
  atg gag ggg gga ccc gca acc acc atg aac agc aaa ggt caa tat cca      48
  Met Glu Gly Gly Pro Ala Thr Thr Met Asn Ser Lys Gly Gln Tyr Pro
    1               5                  10                  15

 aca cag cca acc tac cct gtg cag cct cct ggg aat cca gta tac cct       96
 Thr Gln Pro Thr Tyr Pro Val Gln Pro Pro Gly Asn Pro Val Tyr Pro
              20                  25                  30

 cag acc ttg cat ctt cct cag gct cca ccc tat acc gat gct cca cct      144
 Gln Thr Leu His Leu Pro Gln Ala Pro Pro Tyr Thr Asp Ala Pro Pro
          35                  40                  45

 gcc tac tca gag ctc tat cgt ccg agc ttt gtg cac cca ggg gct gcc      192
 Ala Tyr Ser Glu Leu Tyr Arg Pro Ser Phe Val His Pro Gly Ala Ala
      50                  55                  60

 aca gtc ccc acc atg tca gcc gca ttt cct gga gcc tct ctg tat ctt      240
 Thr Val Pro Thr Met Ser Ala Ala Phe Pro Gly Ala Ser Leu Tyr Leu
  65                  70                  75                  80

 ccc atg gcc cag tct gtg gct gtt ggg cct tta ggt tcc aca atc ccc      288
 Pro Met Ala Gln Ser Val Ala Val Gly Pro Leu Gly Ser Thr Ile Pro
                  85                  90                  95

 atg gct tat tat cca gtc ggt ccc atc tat cca cct ggc tcc aca gtg      336
 Met Ala Tyr Tyr Pro Val Gly Pro Ile Tyr Pro Pro Gly Ser Thr Val
             100                 105                 110

 ctg gtg gaa gga ggg tat gat gca ggt gcc aga ttt gga gct ggg gct      384
 Leu Val Glu Gly Gly Tyr Asp Ala Gly Ala Arg Phe Gly Ala Gly Ala
         115                 120                 125

 act gct ggc aac att cct cct cca cct cct gga tgc cct ccc aat gct      432
 Thr Ala Gly Asn Ile Pro Pro Pro Pro Pro Gly Cys Pro Pro Asn Ala
     130                 135                 140

 gct cag ctt gca gtc atg cag gga gcc aac gtc ctc gta act cag cgg      480
 Ala Gln Leu Ala Val Met Gln Gly Ala Asn Val Leu Val Thr Gln Arg
 145                 150                 155                 160

 aag ggg aac ttc ttc atg ggt ggt tca gat ggt ggc tac acc atc tgg      528
 Lys Gly Asn Phe Phe Met Gly Gly Ser Asp Gly Gly Tyr Thr Ile Trp
                 165                 170                 175

 tga                                                                  531
 






      <210> 324
      <211> 764
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (87)..(350)

      <400> 324
 tcgtgccgag ccactccagg ggcagggacc atttcttcat tttctgaaag cactttaatg     60

 attccccttc ccccaaactc caggga atg gag ggg gga ccc gca acc acc atg     113
                              Met Glu Gly Gly Pro Ala Thr Thr Met
                                1               5

 aac agc aaa ggt caa tat cca aca cag cca acc tac cct gtg cag cct      161
 Asn Ser Lys Gly Gln Tyr Pro Thr Gln Pro Thr Tyr Pro Val Gln Pro
  10                  15                  20                  25

 cct ggg aat cca gta tac cct cag acc ttg cat ctt cct cag gct cca      209
 Pro Gly Asn Pro Val Tyr Pro Gln Thr Leu His Leu Pro Gln Ala Pro
                  30                  35                  40

 ccc tat acc gat gct cca cct cct gga tgc cct ccc aat gct gct cag      257
 Pro Tyr Thr Asp Ala Pro Pro Pro Gly Cys Pro Pro Asn Ala Ala Gln
              45                  50                  55

 ctt gca gtc atg cag gga gcc aac gtc ctc gta act cag cgg aag ggg      305
 Leu Ala Val Met Gln Gly Ala Asn Val Leu Val Thr Gln Arg Lys Gly
          60                  65                  70

 aac ttc ttc atg ggt ggt tca gat ggt ggc tac acc atc tgg tga gga      353
 Asn Phe Phe Met Gly Gly Ser Asp Gly Gly Tyr Thr Ile Trp 
      75                  80                  85

 accaaggcca cctttgtgcc gggaaagaca tcacatacct tcagcacttc tcacaatgta    413

 actgctttag tcatattaac ctgaagttgc agtttagaca catgttgttg gggtgtcttt    473

 ctggtgccca aactttcagg cacttttcaa atttaataag gaaccatgta atggtagcag    533

 tacctcccta aagcattttg aggtagggga ggtatccatt cataaaatga atgtgggtga    593

 agccgcccta aggattttcc tttaatttct ctggagtaat actgtaccat actggtcttt    653

 gcttttagta ataaaacatc aaattaggtt tggagggaac tttgatcttc ctaagaatta    713

 aagttgccaa attattctga ttggtaaaaa aaaaaaaaaa aaaaaaaaat c             764




      <210> 325
      <211> 816
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(816)

      <400> 325
  atg gca tgt gct cgc cta cta ata tcg gtg tac tct gaa agt ggg gag      48
  Met Ala Cys Ala Arg Leu Leu Ile Ser Val Tyr Ser Glu Ser Gly Glu
    1               5                  10                  15

 tca tct ggc aaa aat gtc act ttg cct gct gta ttc aag gct cct att       96
 Ser Ser Gly Lys Asn Val Thr Leu Pro Ala Val Phe Lys Ala Pro Ile
              20                  25                  30

 cga cca gat att gtg aac ttt gtt cac acc aac ttg cac aaa aac aac      144
 Arg Pro Asp Ile Val Asn Phe Val His Thr Asn Leu His Lys Asn Asn
          35                  40                  45

 aga cag ccc tat gct gtc agt gaa tta gca ggt cgt cag acc agt gct      192
 Arg Gln Pro Tyr Ala Val Ser Glu Leu Ala Gly Arg Gln Thr Ser Ala
      50                  55                  60

 gaa tct tgg ggt acc ggc aga gct gtg gct caa att ccc aga gtt caa      240
 Glu Ser Trp Gly Thr Gly Arg Ala Val Ala Gln Ile Pro Arg Val Gln
  65                  70                  75                  80

 gcc tta tca gca ctg gtc atg tct aaa ggt cat agt att gag gaa gtt      288
 Ala Leu Ser Ala Leu Val Met Ser Lys Gly His Ser Ile Glu Glu Val
                  85                  90                  95

 cct gaa ctt cct ttg gta gtc gaa gat aaa gtt gaa ggg tac aag aag      336
 Pro Glu Leu Pro Leu Val Val Glu Asp Lys Val Glu Gly Tyr Lys Lys
             100                 105                 110

 acc aag gag gct gtt tcg ctt ctt aag aaa ttt aaa gcc tgg aat gat      384
 Thr Lys Glu Ala Val Ser Leu Leu Lys Lys Phe Lys Ala Trp Asn Asp
         115                 120                 125

 atc aaa aag gac tat gcc tct cag cga atg aga gct ggc aag ggc aaa      432
 Ile Lys Lys Asp Tyr Ala Ser Gln Arg Met Arg Ala Gly Lys Gly Lys
     130                 135                 140

 atg aga aac cgt cat tgt atc cag tgc aca ggc ccc tac atc atc tat      480
 Met Arg Asn Arg His Cys Ile Gln Cys Thr Gly Pro Tyr Ile Ile Tyr
 145                 150                 155                 160

 aat gag gat aat ggt atc atc aag gcc ttc aga aac atc cct gga att      528
 Asn Glu Asp Asn Gly Ile Ile Lys Ala Phe Arg Asn Ile Pro Gly Ile
                 165                 170                 175

 act ctg ctt aat gcc agg aat cac aag ctc tgg gtg gat aag gca gca      576
 Thr Leu Leu Asn Ala Arg Asn His Lys Leu Trp Val Asp Lys Ala Ala
             180                 185                 190

 gca gca gct gaa gca cta gaa gcc aaa tcg gat gag aag ggg gtt gca      624
 Ala Ala Ala Glu Ala Leu Glu Ala Lys Ser Asp Glu Lys Gly Val Ala
         195                 200                 205

 ggc aag aag cct gtg gta ggt aag aaa gga aag aag att gct gtt ggt      672
 Gly Lys Lys Pro Val Val Gly Lys Lys Gly Lys Lys Ile Ala Val Gly
     210                 215                 220

 gtt aag aag cag aag aaa cct ctg gtg gga aaa aag gca gca gct acc      720
 Val Lys Lys Gln Lys Lys Pro Leu Val Gly Lys Lys Ala Ala Ala Thr
 225                 230                 235                 240

 aag aaa cca gtc cct gaa aag aag cca gca gaa aag aaa cct act aca      768
 Lys Lys Pro Val Pro Glu Lys Lys Pro Ala Glu Lys Lys Pro Thr Thr
                 245                 250                 255

 gag gaa aga agc ctg ctg cat aaa ctc tta aat ttg att att cca taa      816
 Glu Glu Arg Ser Leu Leu His Lys Leu Leu Asn Leu Ile Ile Pro 
             260                 265                 270





      <210> 326
      <211> 813
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(813)

      <400> 326
  atg gag ggg gtt ttg tac aag tgg acc aac tat ctc aca ggt tgg cag      48
  Met Glu Gly Val Leu Tyr Lys Trp Thr Asn Tyr Leu Thr Gly Trp Gln
    1               5                  10                  15

 cct cgt tgg ttt gtt tta gat aat gga atc tta tcc tat tat gat tca       96
 Pro Arg Trp Phe Val Leu Asp Asn Gly Ile Leu Ser Tyr Tyr Asp Ser
              20                  25                  30

 caa gat gat gtt tgc aaa ggg agc aaa gga agc ata aag atg gca gtt      144
 Gln Asp Asp Val Cys Lys Gly Ser Lys Gly Ser Ile Lys Met Ala Val
          35                  40                  45

 tgt gaa att aaa gca gac aac aca aga atg gaa tta atc att cct gga      192
 Cys Glu Ile Lys Ala Asp Asn Thr Arg Met Glu Leu Ile Ile Pro Gly
      50                  55                  60

 gag cag cat ttc tac atg aag gca gtg aac gca gct gaa aga cag agg      240
 Glu Gln His Phe Tyr Met Lys Ala Val Asn Ala Ala Glu Arg Gln Arg
  65                  70                  75                  80

 tgg ctg gtc gct ctg ggg agc tcc aaa gca tgt ttg act gat aca agg      288
 Trp Leu Val Ala Leu Gly Ser Ser Lys Ala Cys Leu Thr Asp Thr Arg
                  85                  90                  95

 act aaa aac gaa aaa gaa aga agt gaa acc agt gaa tcg ctg aaa acc      336
 Thr Lys Asn Glu Lys Glu Arg Ser Glu Thr Ser Glu Ser Leu Lys Thr
             100                 105                 110

 aaa atg tct gaa ctt cgc ctc tac tgt gac ctc tta atg cag caa gtt      384
 Lys Met Ser Glu Leu Arg Leu Tyr Cys Asp Leu Leu Met Gln Gln Val
         115                 120                 125

 cat acg ata cag gaa ttt gtt cac cac gat gag aat cat tca tct cct      432
 His Thr Ile Gln Glu Phe Val His His Asp Glu Asn His Ser Ser Pro
     130                 135                 140

 agt gca gag gta gag cga aga gga tct ctt cac aac atg aat gaa gcc      480
 Ser Ala Glu Val Glu Arg Arg Gly Ser Leu His Asn Met Asn Glu Ala
 145                 150                 155                 160

 tct tct ctg ctt agt gcc acg tgt aac aca ttc atc aca acg ctt gag      528
 Ser Ser Leu Leu Ser Ala Thr Cys Asn Thr Phe Ile Thr Thr Leu Glu
                 165                 170                 175

 gaa tgt gtg aag ata gcc aat gcc aag ttt aaa cct gag atg ttt caa      576
 Glu Cys Val Lys Ile Ala Asn Ala Lys Phe Lys Pro Glu Met Phe Gln
             180                 185                 190

 ctg cac cat ccg gat ccc tta gtt tct cct gtg tca cct tct cct gtt      624
 Leu His His Pro Asp Pro Leu Val Ser Pro Val Ser Pro Ser Pro Val
         195                 200                 205

 caa atg agg act gga gtt aat att gac agg atg ttt aac gtt ttt atc      672
 Gln Met Arg Thr Gly Val Asn Ile Asp Arg Met Phe Asn Val Phe Ile
     210                 215                 220

 aat gtc ttc ata gga cct gtt cac tgt tca aaa aat aca ctt aat gga      720
 Asn Val Phe Ile Gly Pro Val His Cys Ser Lys Asn Thr Leu Asn Gly
 225                 230                 235                 240

 gat ttg gca tca gca acc att cct gaa gaa agc aga ctt atg gcc aaa      768
 Asp Leu Ala Ser Ala Thr Ile Pro Glu Glu Ser Arg Leu Met Ala Lys
                 245                 250                 255

 aaa caa tct gaa tca gaa gat act ctt cca tcc ttc tct tcc tga          813
 Lys Gln Ser Glu Ser Glu Asp Thr Leu Pro Ser Phe Ser Ser 
             260                 265                 270





      <210> 327
      <211> 711
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(651)

      <400> 327
  atg gag gcc gag ggc tgc cgc tac caa ttt cgg gtc gcg ctg ctg ggg      48
  Met Glu Ala Glu Gly Cys Arg Tyr Gln Phe Arg Val Ala Leu Leu Gly
    1               5                  10                  15

 gac gcg gcg gtg ggc aag acg tcg ctg ctg cgg agc tac gtg gcg ggc       96
 Asp Ala Ala Val Gly Lys Thr Ser Leu Leu Arg Ser Tyr Val Ala Gly
              20                  25                  30

 gcg cct ggc gcc cca cag ccc aag ccc gag ccc acg gtg ggc gcc gag      144
 Ala Pro Gly Ala Pro Gln Pro Lys Pro Glu Pro Thr Val Gly Ala Glu
          35                  40                  45

 tgc tac cgc cgc gcg ctg cag ctg cgg gct ggg ccg cgg gtc aag ctg      192
 Cys Tyr Arg Arg Ala Leu Gln Leu Arg Ala Gly Pro Arg Val Lys Leu
      50                  55                  60

 cag ctc tgg gac acc gcg ggc cac gag cgc ttc agc tgc atc acc ggg      240
 Gln Leu Trp Asp Thr Ala Gly His Glu Arg Phe Ser Cys Ile Thr Gly
  65                  70                  75                  80

 tcc ttt tac cgg aat gtg gtg ggt gtc ctg ctg gtc ttt gat gtg aca      288
 Ser Phe Tyr Arg Asn Val Val Gly Val Leu Leu Val Phe Asp Val Thr
                  85                  90                  95

 aac agg aag tcc ttt gaa cac atc caa gac tgg cac cag gag gtc atg      336
 Asn Arg Lys Ser Phe Glu His Ile Gln Asp Trp His Gln Glu Val Met
             100                 105                 110

 gcc act cag ggc ccg gac aag gtc atc ttc ctg ctg gtt ggc cac aag      384
 Ala Thr Gln Gly Pro Asp Lys Val Ile Phe Leu Leu Val Gly His Lys
         115                 120                 125

 agt gac ctg cag agc acc cgc tgt gtc tca gcc cag gag gcc gag gag      432
 Ser Asp Leu Gln Ser Thr Arg Cys Val Ser Ala Gln Glu Ala Glu Glu
     130                 135                 140

 cta gct gcc tcc ctg ggc atg gcc ttc gtg gag acc tcg gtt aaa aac      480
 Leu Ala Ala Ser Leu Gly Met Ala Phe Val Glu Thr Ser Val Lys Asn
 145                 150                 155                 160

 aac tgc aat gtg gac ctg gcc ttt gac acc ctc gct gat gct atc cag      528
 Asn Cys Asn Val Asp Leu Ala Phe Asp Thr Leu Ala Asp Ala Ile Gln
                 165                 170                 175

 cag gcc ctg cag cag ggg gac atc aag cta gaa gag ggc tgg ggg ggt      576
 Gln Ala Leu Gln Gln Gly Asp Ile Lys Leu Glu Glu Gly Trp Gly Gly
             180                 185                 190

 gtc cgg ctc atc cac aag acc caa atc ccc agg tcc ccc agc agg aag      624
 Val Arg Leu Ile His Lys Thr Gln Ile Pro Arg Ser Pro Ser Arg Lys
         195                 200                 205

 cag cac tca ggc cca tgc cag tgt tga ctcta ggagagaaag ggttaagccg      676
 Gln His Ser Gly Pro Cys Gln Cys 
     210                 215

 tcccagctta gccactgggg ggggggggta atctc                               711




      <210> 328
      <211> 3234
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (299)..(3184)

      <400> 328
 cgaggacaga ggtgtacaga gggacctgac tcgagtgccc cttcctacgc agctatacaa     60

 ctgggccgca ccagaagtga tcttacagaa ggcagccaca gtgaaatcag acatctacag    120

 cttttctatg atcatgcagg agattttaac agatgacata ccctggaagg gcttagatgg    180

 ctcagttgtt aaaaaagccg tagtctcggg gaattattta gaagctgatg tcaggcttcc    240

 gaaaccttac tatgatattg ttaagtcagg catccacgtc aagcagaaag accgaact      298                                                                 
 atg aac ctt caa gat atc cgg tat att ctg aag aat gac tta aag gca      346
 Met Asn Leu Gln Asp Ile Arg Tyr Ile Leu Lys Asn Asp Leu Lys Ala
   1               5                  10                  15

 agc cct gaa gat ttt act gga gcc cag aga act caa cca acc gag agc      394
 Ser Pro Glu Asp Phe Thr Gly Ala Gln Arg Thr Gln Pro Thr Glu Ser
              20                  25                  30

 ccc aga gtg cag aga tac gga ctc cat ccc gat gtc aat gtc tat cta      442
 Pro Arg Val Gln Arg Tyr Gly Leu His Pro Asp Val Asn Val Tyr Leu
          35                  40                  45

 gga ctg act tca gaa cac ccc aga gag aca cct gac atg gaa atc ata      490
 Gly Leu Thr Ser Glu His Pro Arg Glu Thr Pro Asp Met Glu Ile Ile
      50                  55                  60

 gaa cta aag gaa atg ggc agt caa cct cat tca cca agg gtt cac tct      538
 Glu Leu Lys Glu Met Gly Ser Gln Pro His Ser Pro Arg Val His Ser
  65                  70                  75                  80

 tta ttc act gag ggg aca cta gat cct cag gcc cca gat cca tgt ctg      586
 Leu Phe Thr Glu Gly Thr Leu Asp Pro Gln Ala Pro Asp Pro Cys Leu
                  85                  90                  95

 atg gcc agg gag act cag aat caa gat gct cct tgc cct gct cca ttt      634
 Met Ala Arg Glu Thr Gln Asn Gln Asp Ala Pro Cys Pro Ala Pro Phe
             100                 105                 110

 atg gca gaa gag gcc agc agc ccc agc aca ggt cag cca agc ctc tgc      682
 Met Ala Glu Glu Ala Ser Ser Pro Ser Thr Gly Gln Pro Ser Leu Cys
         115                 120                 125

 agt ttc gaa atc aac gag atc tac tca ggc tgc ttg att ttg gaa gat      730
 Ser Phe Glu Ile Asn Glu Ile Tyr Ser Gly Cys Leu Ile Leu Glu Asp
     130                 135                 140

 gac ata gaa gag cct cca gga gct gct tca tct ttg gag gca gac gga      778
 Asp Ile Glu Glu Pro Pro Gly Ala Ala Ser Ser Leu Glu Ala Asp Gly
 145                 150                 155                 160

 cct aac cag gta gat gaa ctg aaa tcc atg gaa gaa gag ctg gat aag      826
 Pro Asn Gln Val Asp Glu Leu Lys Ser Met Glu Glu Glu Leu Asp Lys
                 165                 170                 175

 atg gag aga gag gcg tgt tgt ttt ggc agt gag gat gag agc tct tca      874
 Met Glu Arg Glu Ala Cys Cys Phe Gly Ser Glu Asp Glu Ser Ser Ser
             180                 185                 190

 aaa gct gag aca gag tac tct ttt gat gac tgg gac tgg caa aac ggt      922
 Lys Ala Glu Thr Glu Tyr Ser Phe Asp Asp Trp Asp Trp Gln Asn Gly
         195                 200                 205

 tca ctc agt tca ctc agc ctt cct gag tca acc aga gaa gcc aag agc      970
 Ser Leu Ser Ser Leu Ser Leu Pro Glu Ser Thr Arg Glu Ala Lys Ser
     210                 215                 220

 aat ttg aac aac atg tcc acg act gag gag tat ctc atc agt aag tgt     1018
 Asn Leu Asn Asn Met Ser Thr Thr Glu Glu Tyr Leu Ile Ser Lys Cys
 225                 230                 235                 240

 gtg ctg gat cta aag att atg cag aca ata atg cac gag aat gat gat     1066
 Val Leu Asp Leu Lys Ile Met Gln Thr Ile Met His Glu Asn Asp Asp
                 245                 250                 255

 agg ctg agg aat atc gag cag ata tta gat gaa gtc gag atg aaa cag     1114
 Arg Leu Arg Asn Ile Glu Gln Ile Leu Asp Glu Val Glu Met Lys Gln
             260                 265                 270

 aag gaa cag gaa gag cgc atg tct tta tgg gcc act tca aga gag ttt     1162
 Lys Glu Gln Glu Glu Arg Met Ser Leu Trp Ala Thr Ser Arg Glu Phe
         275                 280                 285

 aca aat gcc tac aag tta cct ctg gcc gtg ggc cct cca tct tta aac     1210
 Thr Asn Ala Tyr Lys Leu Pro Leu Ala Val Gly Pro Pro Ser Leu Asn
     290                 295                 300

 tat att cct cct gtc cta cag ctt tca ggg ggt cag aag cca gac acc     1258
 Tyr Ile Pro Pro Val Leu Gln Leu Ser Gly Gly Gln Lys Pro Asp Thr
 305                 310                 315                 320

 agt ggc aac tac cca acc cta cca aga ttt cca aga atg ctg ccg act     1306
 Ser Gly Asn Tyr Pro Thr Leu Pro Arg Phe Pro Arg Met Leu Pro Thr
                 325                 330                 335

 ctt tgt gac cct gga aaa cag aac aca gat gaa caa ttt cag tgc act     1354
 Leu Cys Asp Pro Gly Lys Gln Asn Thr Asp Glu Gln Phe Gln Cys Thr
             340                 345                 350

 caa gga gcc aag gac agt ttg gaa aca agc agg atc caa aat acc agt     1402
 Gln Gly Ala Lys Asp Ser Leu Glu Thr Ser Arg Ile Gln Asn Thr Ser
         355                 360                 365

 agc cag gga aga cct aga gag tcc act gcc caa gcc aaa gcc aca cag     1450
 Ser Gln Gly Arg Pro Arg Glu Ser Thr Ala Gln Ala Lys Ala Thr Gln
     370                 375                 380

 ttt aat agt gca ctc ttc act ctg tca agc cac cgg cag gga cct tct     1498
 Phe Asn Ser Ala Leu Phe Thr Leu Ser Ser His Arg Gln Gly Pro Ser
 385                 390                 395                 400

 gca tca ccc agc tgt cac tgg gac tct acc agg atg agt gtg gaa cct     1546
 Ala Ser Pro Ser Cys His Trp Asp Ser Thr Arg Met Ser Val Glu Pro
                 405                 410                 415

 gtt tct tct gaa atc tat aat gca gag tcc aga aat aaa gat gat gga     1594
 Val Ser Ser Glu Ile Tyr Asn Ala Glu Ser Arg Asn Lys Asp Asp Gly
             420                 425                 430

 aag gta cac tta aaa tgg aaa atg gag gtg aaa gaa atg gca aag aaa     1642
 Lys Val His Leu Lys Trp Lys Met Glu Val Lys Glu Met Ala Lys Lys
         435                 440                 445

 gca gct act gga cag ctc aca gta cct cct tgg cat cct cag agt agt     1690
 Ala Ala Thr Gly Gln Leu Thr Val Pro Pro Trp His Pro Gln Ser Ser
     450                 455                 460

 ctg act tta gag agc gag gct gaa aat gag ccc gac gcc ctg ctg cag     1738
 Leu Thr Leu Glu Ser Glu Ala Glu Asn Glu Pro Asp Ala Leu Leu Gln
 465                 470                 475                 480

 ccc ccc att agg agc cca gaa aac acg gat tgg cag cga gtt att gag     1786
 Pro Pro Ile Arg Ser Pro Glu Asn Thr Asp Trp Gln Arg Val Ile Glu
                 485                 490                 495

 tat cat agg gaa aat gat gag ccc aga gga aat ggc aag ttt gac aag     1834
 Tyr His Arg Glu Asn Asp Glu Pro Arg Gly Asn Gly Lys Phe Asp Lys
             500                 505                 510

 acg ggc aac aat gac tgt gac agt gac cag cat ggc aga cag ccc agg     1882
 Thr Gly Asn Asn Asp Cys Asp Ser Asp Gln His Gly Arg Gln Pro Arg
         515                 520                 525

 ctt gga agc ttc acc agt atc agg cac cca tct ccc aga caa aag gag     1930
 Leu Gly Ser Phe Thr Ser Ile Arg His Pro Ser Pro Arg Gln Lys Glu
     530                 535                 540

 caa cca gag cat agt gaa gcc ttc caa gca agt tct gac aca ttg gtg     1978
 Gln Pro Glu His Ser Glu Ala Phe Gln Ala Ser Ser Asp Thr Leu Val
 545                 550                 555                 560

 gct gta gag aaa tct tac agt acc tcg agt ccc ata gaa gag gac ttt     2026
 Ala Val Glu Lys Ser Tyr Ser Thr Ser Ser Pro Ile Glu Glu Asp Phe
                 565                 570                 575

 gaa gga ata caa ggt gca ttt gcc caa cct caa gtc tct ggt gag gaa     2074
 Glu Gly Ile Gln Gly Ala Phe Ala Gln Pro Gln Val Ser Gly Glu Glu
             580                 585                 590

 aag ttc caa atg aga aaa att ctt gga aag aat gct gag att ttg ccc     2122
 Lys Phe Gln Met Arg Lys Ile Leu Gly Lys Asn Ala Glu Ile Leu Pro
         595                 600                 605

 agg tct caa ttt caa cct gta cga agt act gaa gat gaa caa gaa gag     2170
 Arg Ser Gln Phe Gln Pro Val Arg Ser Thr Glu Asp Glu Gln Glu Glu
     610                 615                 620

 aca tca aag gag tca cca aag gaa ctg aaa gag aaa gac ata tca ttg     2218
 Thr Ser Lys Glu Ser Pro Lys Glu Leu Lys Glu Lys Asp Ile Ser Leu
 625                 630                 635                 640

 acg gat att caa gac ctg tct agt atc tcc tat gaa cca gac agc tct     2266
 Thr Asp Ile Gln Asp Leu Ser Ser Ile Ser Tyr Glu Pro Asp Ser Ser
                 645                 650                 655

 ttt aag gaa gct tca tgc aaa aca ccc aaa ata aac cat gca cct acc     2314
 Phe Lys Glu Ala Ser Cys Lys Thr Pro Lys Ile Asn His Ala Pro Thr
             660                 665                 670

 agt gtc agc act cca ctc agc cca ggg tcc gtt tct tca gct gcc agt     2362
 Ser Val Ser Thr Pro Leu Ser Pro Gly Ser Val Ser Ser Ala Ala Ser
         675                 680                 685

 cag tat aaa gac tgc ctt gaa agt atc aca ttt cag gtt aag aca gag     2410
 Gln Tyr Lys Asp Cys Leu Glu Ser Ile Thr Phe Gln Val Lys Thr Glu
     690                 695                 700

 ttt gcc tct tgc tgg aac agt caa gaa ttt att caa act ttg tct gat     2458
 Phe Ala Ser Cys Trp Asn Ser Gln Glu Phe Ile Gln Thr Leu Ser Asp
 705                 710                 715                 720

 gac ttt ata agt gtc cga gag aga gca aag aaa ctg gat tct ctc ctt     2506
 Asp Phe Ile Ser Val Arg Glu Arg Ala Lys Lys Leu Asp Ser Leu Leu
                 725                 730                 735

 act tcc tct gaa act ccc cct tca aga ctg act ggt ctt aaa aga ttg     2554
 Thr Ser Ser Glu Thr Pro Pro Ser Arg Leu Thr Gly Leu Lys Arg Leu
             740                 745                 750

 tct tca ttt att ggg gct gga tcc ccc agc ctt gtt aag gca tgt gac     2602
 Ser Ser Phe Ile Gly Ala Gly Ser Pro Ser Leu Val Lys Ala Cys Asp
         755                 760                 765

 tca tca cca ccc cat gcc acc cag aga agg agc ctg cct aaa gta gaa     2650
 Ser Ser Pro Pro His Ala Thr Gln Arg Arg Ser Leu Pro Lys Val Glu
     770                 775                 780

 gcc ttc tct cag cat cgc att gat gag ctg cca cca cca tct cag gag     2698
 Ala Phe Ser Gln His Arg Ile Asp Glu Leu Pro Pro Pro Ser Gln Glu
 785                 790                 795                 800

 cta ctt gat gac att gag ctc ttg aaa cag cag cag ggc tca tcc acg     2746
 Leu Leu Asp Asp Ile Glu Leu Leu Lys Gln Gln Gln Gly Ser Ser Thr
                 805                 810                 815

 gtg ttg cat gag aac aca gca agt gat gga gga ggc act gca aac gat     2794
 Val Leu His Glu Asn Thr Ala Ser Asp Gly Gly Gly Thr Ala Asn Asp
             820                 825                 830

 caa agg cac tta gaa gaa caa gaa act gac agt aaa aaa gaa gat agt     2842
 Gln Arg His Leu Glu Glu Gln Glu Thr Asp Ser Lys Lys Glu Asp Ser
         835                 840                 845

 agt atg ctt ttg tcc aaa gaa act gaa gat ctt gga gag gac aca gag     2890
 Ser Met Leu Leu Ser Lys Glu Thr Glu Asp Leu Gly Glu Asp Thr Glu
     850                 855                 860

 aga gct cac tct act ctg gat gag gac ctg gaa aga tgg ctg cag cca     2938
 Arg Ala His Ser Thr Leu Asp Glu Asp Leu Glu Arg Trp Leu Gln Pro
 865                 870                 875                 880

 cct gag gag agc gtg gag cta caa gac ctt ccc aag ggc tct gaa agg     2986
 Pro Glu Glu Ser Val Glu Leu Gln Asp Leu Pro Lys Gly Ser Glu Arg
                 885                 890                 895

 gag aca aat atc aaa gat caa aaa gtt ggt gaa gag aaa aga aaa agg     3034
 Glu Thr Asn Ile Lys Asp Gln Lys Val Gly Glu Glu Lys Arg Lys Arg
             900                 905                 910

 gaa gat agc att aca cca gag aga agg aaa tca gag ggt gtt cta ggg     3082
 Glu Asp Ser Ile Thr Pro Glu Arg Arg Lys Ser Glu Gly Val Leu Gly
         915                 920                 925

 act tct gaa gaa gat gaa cta aaa tcc tgt ttt tgg aag cga cta ggt     3130
 Thr Ser Glu Glu Asp Glu Leu Lys Ser Cys Phe Trp Lys Arg Leu Gly
     930                 935                 940

 tgg tcc gaa tca tcc agg ata atc gtg ctg gat cag agt gac ttg tca     3178
 Trp Ser Glu Ser Ser Arg Ile Ile Val Leu Asp Gln Ser Asp Leu Ser
 945                 950                 955                 960

 gac tga ttggaattgg atcatagacg gactcctggc ctgagtttga gtgtcctggt      3234
 Asp 






      <210> 329
      <211> 2487
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2487)

      <400> 329
  atg gcc agt cta gat ttt aca cta gat cag tcc tgc ttc aca tgt ctc      48
  Met Ala Ser Leu Asp Phe Thr Leu Asp Gln Ser Cys Phe Thr Cys Leu
    1               5                  10                  15

 ccg gct ggc cag ccc cgg atg tcc ggc cac tgt gag ccg ata gct ttt       96
 Pro Ala Gly Gln Pro Arg Met Ser Gly His Cys Glu Pro Ile Ala Phe
              20                  25                  30

 ctg ctg ttt gtt ttc tac ctg tgt gca gac ctg gtc cag aac act act      144
 Leu Leu Phe Val Phe Tyr Leu Cys Ala Asp Leu Val Gln Asn Thr Thr
          35                  40                  45

 tca gga cag gga ata gtg aca ggc cag cag agc ccc aga ggc gag gtg      192
 Ser Gly Gln Gly Ile Val Thr Gly Gln Gln Ser Pro Arg Gly Glu Val
      50                  55                  60

 gca ggg gct atg gtc ctg cca gga cag gtg aaa ggt gat gtc aac tgg      240
 Ala Gly Ala Met Val Leu Pro Gly Gln Val Lys Gly Asp Val Asn Trp
  65                  70                  75                  80

 cat ctg gca ttc agc tgg tct ctg gag ggg ctc ttt ggc aca cag aag      288
 His Leu Ala Phe Ser Trp Ser Leu Glu Gly Leu Phe Gly Thr Gln Lys
                  85                  90                  95

 atg ggg tcc cgt tta atg gat tct gac atg gat tat gaa agg cca aac      336
 Met Gly Ser Arg Leu Met Asp Ser Asp Met Asp Tyr Glu Arg Pro Asn
             100                 105                 110

 gta gag acc atc aag tgc gtt gtg gtg ggg gac aac gcc gtg ggt aag      384
 Val Glu Thr Ile Lys Cys Val Val Val Gly Asp Asn Ala Val Gly Lys
         115                 120                 125

 acc agg ctc atc tgt gcc cgc gct tgc aat gcc acc ctc acc cag tac      432
 Thr Arg Leu Ile Cys Ala Arg Ala Cys Asn Ala Thr Leu Thr Gln Tyr
     130                 135                 140

 cag ctg ctg gcc acg cat gtg ccc aca gta tgg gcc atc gac caa tat      480
 Gln Leu Leu Ala Thr His Val Pro Thr Val Trp Ala Ile Asp Gln Tyr
 145                 150                 155                 160

 cgt gtg tgc cag gag gtg ctg gaa cgc tcc cga gac gtg gta gat gat      528
 Arg Val Cys Gln Glu Val Leu Glu Arg Ser Arg Asp Val Val Asp Asp
                 165                 170                 175

 gtc agc gtc tct ctg cgc ctc tgg gac acc ttt gga gac cac cac aaa      576
 Val Ser Val Ser Leu Arg Leu Trp Asp Thr Phe Gly Asp His His Lys
             180                 185                 190

 gac cgt cgc ttt gct tat ggg aga tct gat gtg gtg gtt ctg tgc ttc      624
 Asp Arg Arg Phe Ala Tyr Gly Arg Ser Asp Val Val Val Leu Cys Phe
         195                 200                 205

 tcc att gcc aac ccc aat tcc ctc cac cat gtc aag acc atg tgg tac      672
 Ser Ile Ala Asn Pro Asn Ser Leu His His Val Lys Thr Met Trp Tyr
     210                 215                 220

 cca gaa atc aag cac ttc tgc ccc cga gca cct gtc atc ttg gtg ggc      720
 Pro Glu Ile Lys His Phe Cys Pro Arg Ala Pro Val Ile Leu Val Gly
 225                 230                 235                 240

 tgc cag ttg gac ctg cgc tac gct gac ctg gag gct gtc aac agg gct      768
 Cys Gln Leu Asp Leu Arg Tyr Ala Asp Leu Glu Ala Val Asn Arg Ala
                 245                 250                 255

 agg cga ccc ttg gct agg ccc atc aaa cct aat gaa atc ctg ccc cca      816
 Arg Arg Pro Leu Ala Arg Pro Ile Lys Pro Asn Glu Ile Leu Pro Pro
             260                 265                 270

 gag aag ggt cgg gag gtg gcc aag gag ctg ggc atc ccc tac tat gag      864
 Glu Lys Gly Arg Glu Val Ala Lys Glu Leu Gly Ile Pro Tyr Tyr Glu
         275                 280                 285

 acc agc gtg gtg gcc cag ttc ggc atc aag gac gtc ttt gac aac gcc      912
 Thr Ser Val Val Ala Gln Phe Gly Ile Lys Asp Val Phe Asp Asn Ala
     290                 295                 300

 atc cga gct gca ctc atc tcc cgc cgc cac ctg cag ttc tgg aag tcc      960
 Ile Arg Ala Ala Leu Ile Ser Arg Arg His Leu Gln Phe Trp Lys Ser
 305                 310                 315                 320

 cac ctc cgc aat gtg cag cgg cct ctg ctg cag gca ccc ttc cta ccc     1008
 His Leu Arg Asn Val Gln Arg Pro Leu Leu Gln Ala Pro Phe Leu Pro
                 325                 330                 335

 ccc aag cca ccg ccc ccg atc atc gtg gtg ccc gac cct ccc tcc agc     1056
 Pro Lys Pro Pro Pro Pro Ile Ile Val Val Pro Asp Pro Pro Ser Ser
             340                 345                 350

 agc gag gag tgc ccc gcc cac ctc ctg gag gac ccg ctc tgc gcg gac     1104
 Ser Glu Glu Cys Pro Ala His Leu Leu Glu Asp Pro Leu Cys Ala Asp
         355                 360                 365

 gtc atc ctg gtg ctg cag gag cgg gtg cgc atc ttt gcc cac aag atc     1152
 Val Ile Leu Val Leu Gln Glu Arg Val Arg Ile Phe Ala His Lys Ile
     370                 375                 380

 tac ctc tcc acc tcc tcc tcc aag ttc tat gac ctg ttc ctc atg gac     1200
 Tyr Leu Ser Thr Ser Ser Ser Lys Phe Tyr Asp Leu Phe Leu Met Asp
 385                 390                 395                 400

 ctg agt gag ggg gag ctg ggg ggc ccc tcg gag cca ggg ggc acc cac     1248
 Leu Ser Glu Gly Glu Leu Gly Gly Pro Ser Glu Pro Gly Gly Thr His
                 405                 410                 415

 cca gag gac cac cag ggc cac tct gat caa cac cac cac cat cac cac     1296
 Pro Glu Asp His Gln Gly His Ser Asp Gln His His His His His His
             420                 425                 430

 cac cac cat ggg cga gac ttc ctg ctc cga gca gcc agc ttt gac gtg     1344
 His His His Gly Arg Asp Phe Leu Leu Arg Ala Ala Ser Phe Asp Val
         435                 440                 445

 tgc gag agc gtg gat gag gct ggg ggc tcc ggt cct gct ggc ctc cgt     1392
 Cys Glu Ser Val Asp Glu Ala Gly Gly Ser Gly Pro Ala Gly Leu Arg
     450                 455                 460

 gct tcc acc agc gac ggg atc tta cgg ggc aac gga aca ggg tac cta     1440
 Ala Ser Thr Ser Asp Gly Ile Leu Arg Gly Asn Gly Thr Gly Tyr Leu
 465                 470                 475                 480

 ccg ggc agg ggt cgt gtg ctg tct tcc tgg agc cga gct ttt gtg agc     1488
 Pro Gly Arg Gly Arg Val Leu Ser Ser Trp Ser Arg Ala Phe Val Ser
                 485                 490                 495

 atc cag gaa gag atg gca gaa gat cct ctc acc tac aaa tcc cgg ctg     1536
 Ile Gln Glu Glu Met Ala Glu Asp Pro Leu Thr Tyr Lys Ser Arg Leu
             500                 505                 510

 atg gtg gtg gtg aag atg gac agt tcc atc cag ccg ggg ccc ttc cgg     1584
 Met Val Val Val Lys Met Asp Ser Ser Ile Gln Pro Gly Pro Phe Arg
         515                 520                 525

 gct gtc ctc aag tac ctg tac acg ggg gag cta gat gag aac gag cgt     1632
 Ala Val Leu Lys Tyr Leu Tyr Thr Gly Glu Leu Asp Glu Asn Glu Arg
     530                 535                 540

 gac ctc atg cac att gcc cac att gct gag ctg ctc gag gtc ttt gat     1680
 Asp Leu Met His Ile Ala His Ile Ala Glu Leu Leu Glu Val Phe Asp
 545                 550                 555                 560

 ctg cgc atg atg gtg gcc aac att ctc aac aat gag gcc ttc atg aac     1728
 Leu Arg Met Met Val Ala Asn Ile Leu Asn Asn Glu Ala Phe Met Asn
                 565                 570                 575

 cag gag atc acc aag gcc ttc cac gtc cgc cgg acc aac cgg gtt aag     1776
 Gln Glu Ile Thr Lys Ala Phe His Val Arg Arg Thr Asn Arg Val Lys
             580                 585                 590

 gag tgc ttg gca aaa ggc acc ttc tca gat gtg acc ttc atc ctg gat     1824
 Glu Cys Leu Ala Lys Gly Thr Phe Ser Asp Val Thr Phe Ile Leu Asp
         595                 600                 605

 gat ggc acc atc agc gcc cac aag ccc ctg ttg att tcc agc tgt gac     1872
 Asp Gly Thr Ile Ser Ala His Lys Pro Leu Leu Ile Ser Ser Cys Asp
     610                 615                 620

 tgg atg gct gcc atg ttt ggg ggg cca ttt gtg gag agc tcc acc cgg     1920
 Trp Met Ala Ala Met Phe Gly Gly Pro Phe Val Glu Ser Ser Thr Arg
 625                 630                 635                 640

 gag gtg gtg ttt ccc tac aca agc aag agc tgc atg cgg gcc gtg ctg     1968
 Glu Val Val Phe Pro Tyr Thr Ser Lys Ser Cys Met Arg Ala Val Leu
                 645                 650                 655

 gaa tac ctc tac acc ggc atg ttc acc tcc agc ccc gac ctg gat gac     2016
 Glu Tyr Leu Tyr Thr Gly Met Phe Thr Ser Ser Pro Asp Leu Asp Asp
             660                 665                 670

 atg aag ctc atc att cta gcc aac cgc ctc tgc ctg cca cac ctg gtt     2064
 Met Lys Leu Ile Ile Leu Ala Asn Arg Leu Cys Leu Pro His Leu Val
         675                 680                 685

 gcc ctc aca gag cag tac aca gtg acc ggg ctg atg gaa gcg acc cag     2112
 Ala Leu Thr Glu Gln Tyr Thr Val Thr Gly Leu Met Glu Ala Thr Gln
     690                 695                 700

 atg atg gtg gac atc gat ggg gac gtc ctt gtg ttc ctg gaa ctg gct     2160
 Met Met Val Asp Ile Asp Gly Asp Val Leu Val Phe Leu Glu Leu Ala
 705                 710                 715                 720

 cag ttc cac tgt gcg tac cag ctg gcc gac tgg tgt ctc cac cac atc     2208
 Gln Phe His Cys Ala Tyr Gln Leu Ala Asp Trp Cys Leu His His Ile
                 725                 730                 735

 tgc acc aac tac aac aac gtg tgc cgc aag ttc ccc cga gac atg aag     2256
 Cys Thr Asn Tyr Asn Asn Val Cys Arg Lys Phe Pro Arg Asp Met Lys
             740                 745                 750

 gcc atg tcc cca gaa aac cag gag tat ttc gag aag cat cgg tgg cca     2304
 Ala Met Ser Pro Glu Asn Gln Glu Tyr Phe Glu Lys His Arg Trp Pro
         755                 760                 765

 cct gtg tgg tac ctg aag gag gaa gat cat tac cag cgg gca cgg aag     2352
 Pro Val Trp Tyr Leu Lys Glu Glu Asp His Tyr Gln Arg Ala Arg Lys
     770                 775                 780

 gag cgt gag aag gag gac tac ctc cac ctc aag cgg cag ccc aaa cgg     2400
 Glu Arg Glu Lys Glu Asp Tyr Leu His Leu Lys Arg Gln Pro Lys Arg
 785                 790                 795                 800

 cgt tgg ctc ttc tgg aac agt cca tcc tcc ccg tct tcc tcg gca gcc     2448
 Arg Trp Leu Phe Trp Asn Ser Pro Ser Ser Pro Ser Ser Ser Ala Ala
                 805                 810                 815

 tcc tcc tca tcc cca tct tcc tcc tcg gct gtg gtc tga                 2487
 Ser Ser Ser Ser Pro Ser Ser Ser Ser Ala Val Val 
             820                 825





      <210> 330
      <211> 2005
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (254)..(2005)

      <400> 330
 ctgctctgcc gcctgccacc gctgcccgag cccggtgggc ggcggcactg cgtgctgggg     60

 aagcacagat tcttgtgccc tctgtgacct tgagcctgcc actgacctct ctgagccctg    120

 ctggctgcct ccccaatagg aatgacaact cctacttcat gaggttgtag tgggggctca    180

 ggggcacagg gagatcccgc tgaggctccc agggccctgc ctggtgcttg gcaaggagca    240

 gttctgatgg ggg   atg tgt cag ctg cca gag gct cag agc caa ggc ccc     289
                  Met Cys Gln Leu Pro Glu Ala Gln Ser Gln Gly Pro
                    1               5                  10

 tcc cac atc tcc tgc ctg cgt gca ttc ctc aca tcc tgg cct tgg gcc      337
 Ser His Ile Ser Cys Leu Arg Ala Phe Leu Thr Ser Trp Pro Trp Ala
          15                  20                  25

 aaa ctg ctc agc ctc agc cgc ctt ccc tcg atg ctg gag gat cag gtc      385
 Lys Leu Leu Ser Leu Ser Arg Leu Pro Ser Met Leu Glu Asp Gln Val
      30                  35                  40

 caa gag atg cct ctc ccc gac cag cct agg act gca gtc agc att ccc      433
 Gln Glu Met Pro Leu Pro Asp Gln Pro Arg Thr Ala Val Ser Ile Pro
  45                  50                  55                  60

 agg ccc cag tgt ggt ctg tgg ggc tgt gtg cag agt gtg cga gac gct      481
 Arg Pro Gln Cys Gly Leu Trp Gly Cys Val Gln Ser Val Arg Asp Ala
                  65                  70                  75

 atg tcc agc aaa ggc tcc gtg gtt ctg gcc tac agt ggc ggc ctg gac      529
 Met Ser Ser Lys Gly Ser Val Val Leu Ala Tyr Ser Gly Gly Leu Asp
              80                  85                  90

 acc tcg tgc atc ctc gtg tgg ctg aag gaa caa ggc tat gac gtc att      577
 Thr Ser Cys Ile Leu Val Trp Leu Lys Glu Gln Gly Tyr Asp Val Ile
          95                 100                 105

 gcc tat ctg gcc aac att ggc cag aag gaa gac ttc gag gaa gcc agg      625
 Ala Tyr Leu Ala Asn Ile Gly Gln Lys Glu Asp Phe Glu Glu Ala Arg
     110                 115                 120

 aag aag gca ctg aag ctt ggg gcc aaa aag gtg ttc att gag gat gtc      673
 Lys Lys Ala Leu Lys Leu Gly Ala Lys Lys Val Phe Ile Glu Asp Val
 125                 130                 135                 140

 agc agg gag ttt gtg gag gag ttc atc tgg ccg gcc atc cag tcc agc      721
 Ser Arg Glu Phe Val Glu Glu Phe Ile Trp Pro Ala Ile Gln Ser Ser
                 145                 150                 155

 gca ctg tat gag gac cgc tac ctc ctg ggc acc tct ctt gcc agg ccc      769
 Ala Leu Tyr Glu Asp Arg Tyr Leu Leu Gly Thr Ser Leu Ala Arg Pro
             160                 165                 170

 tgc atc gcc cgc aaa caa gtg gaa atc gcc cag cgg gag ggg gcc aag      817
 Cys Ile Ala Arg Lys Gln Val Glu Ile Ala Gln Arg Glu Gly Ala Lys
         175                 180                 185

 tat gtg tcc cac ggc gcc aca gga aag ggg aac gat cag gtc cgg ttt      865
 Tyr Val Ser His Gly Ala Thr Gly Lys Gly Asn Asp Gln Val Arg Phe
     190                 195                 200

 gag ctc agc tgc tac tca ctg gcc ccc cag ata aag gtc att gct ccc      913
 Glu Leu Ser Cys Tyr Ser Leu Ala Pro Gln Ile Lys Val Ile Ala Pro
 205                 210                 215                 220

 tgg agg atg cct gaa ttc tac aac cgg ttc aag ggc cgc aat gac ctg      961
 Trp Arg Met Pro Glu Phe Tyr Asn Arg Phe Lys Gly Arg Asn Asp Leu
                 225                 230                 235

 atg gag tac gca aag caa cac ggg att ccc atc ccg gtc act ccc aag     1009
 Met Glu Tyr Ala Lys Gln His Gly Ile Pro Ile Pro Val Thr Pro Lys
             240                 245                 250

 aac ccg tgg agc atg gat gag aac ctc atg cac atc agc tac gag gct     1057
 Asn Pro Trp Ser Met Asp Glu Asn Leu Met His Ile Ser Tyr Glu Ala
         255                 260                 265

 gga atc ctg gag aac ccc aag aac caa gcg cct cca ggt ctc tac acg     1105
 Gly Ile Leu Glu Asn Pro Lys Asn Gln Ala Pro Pro Gly Leu Tyr Thr
     270                 275                 280

 aag acc cag gac cca gcc aaa gcc ccc aac acc cct gac att ctc gag     1153
 Lys Thr Gln Asp Pro Ala Lys Ala Pro Asn Thr Pro Asp Ile Leu Glu
 285                 290                 295                 300

 atc gag ttc aaa aaa ggg gtc cct gtg aag gtg acc aac gtc aag gat     1201
 Ile Glu Phe Lys Lys Gly Val Pro Val Lys Val Thr Asn Val Lys Asp
                 305                 310                 315

 ggc acc acc cac cag acc tcc ttg gag ctc ttc atg tac ctg aac gaa     1249
 Gly Thr Thr His Gln Thr Ser Leu Glu Leu Phe Met Tyr Leu Asn Glu
             320                 325                 330

 gtc gcg ggc aag cat ggc gtg ggc cgt att gac atc gtg gag aac cgc     1297
 Val Ala Gly Lys His Gly Val Gly Arg Ile Asp Ile Val Glu Asn Arg
         335                 340                 345

 ttc att gga atg aag tcc cga ggt atc tac gag acc cca gca ggc acc     1345
 Phe Ile Gly Met Lys Ser Arg Gly Ile Tyr Glu Thr Pro Ala Gly Thr
     350                 355                 360

 atc ctt tac cat gct cat tta gac atc gag gcc ttc acc atg gac cgg     1393
 Ile Leu Tyr His Ala His Leu Asp Ile Glu Ala Phe Thr Met Asp Arg
 365                 370                 375                 380

 gaa gtg cgc aaa atc aaa caa ggc ctg ggc ttg aaa ttt gct gag ctg     1441
 Glu Val Arg Lys Ile Lys Gln Gly Leu Gly Leu Lys Phe Ala Glu Leu
                 385                 390                 395

 gtg tat acc ggt ttc tgg cac agc cct gag tgt gaa ttt gtc cgc cac     1489
 Val Tyr Thr Gly Phe Trp His Ser Pro Glu Cys Glu Phe Val Arg His
             400                 405                 410

 tgc atc gcc aag tcc cag gag cga gtg gaa ggg aaa gtg cag gtg tcc     1537
 Cys Ile Ala Lys Ser Gln Glu Arg Val Glu Gly Lys Val Gln Val Ser
         415                 420                 425

 gtc ctc aag ggc cag gtg tac atc ctc ggc cgg gag tcc cca ctg tct     1585
 Val Leu Lys Gly Gln Val Tyr Ile Leu Gly Arg Glu Ser Pro Leu Ser
     430                 435                 440

 ctc tac aat gag gag ctg gtg agc atg aac gtg cag ggt gat tat gag     1633
 Leu Tyr Asn Glu Glu Leu Val Ser Met Asn Val Gln Gly Asp Tyr Glu
 445                 450                 455                 460

 cca act gat gcc acc ggg ttc atc aac atc aaa ttc ctc agc cca cat     1681
 Pro Thr Asp Ala Thr Gly Phe Ile Asn Ile Lys Phe Leu Ser Pro His
                 465                 470                 475

 ccg gtg acc tat caa att gag gca agt tta aag cca gag cag cct ggt     1729
 Pro Val Thr Tyr Gln Ile Glu Ala Ser Leu Lys Pro Glu Gln Pro Gly
             480                 485                 490

 gtc acg ctg gtg tcc atc cca gtc ttc ctg gca cct tcc tgg cac aaa     1777
 Val Thr Leu Val Ser Ile Pro Val Phe Leu Ala Pro Ser Trp His Lys
         495                 500                 505

 gcc tca gag ctg atc ccg acc cag tcc ttc cga gca cag gcc tgg ggc     1825
 Ala Ser Glu Leu Ile Pro Thr Gln Ser Phe Arg Ala Gln Ala Trp Gly
     510                 515                 520

 tca gtg agg ttc atg gcc ccg ctc ctg gga gca gct gac cct gtg cac     1873
 Ser Val Arg Phe Met Ala Pro Leu Leu Gly Ala Ala Asp Pro Val His
 525                 530                 535                 540

 cct gct tgg ctg ggt cca ccc atc tgc caa tgc tgt gtc cag aag ccc     1921
 Pro Ala Trp Leu Gly Pro Pro Ile Cys Gln Cys Cys Val Gln Lys Pro
                 545                 550                 555

 cac gtc agc tct gtc ctg gct gtg gac atc ctg gat gta aga cgt ggg     1969
 His Val Ser Ser Val Leu Ala Val Asp Ile Leu Asp Val Arg Arg Gly
             560                 565                 570

 agg aac ccc agc cat cac ctc tac aag aaa act taa                     2005
 Arg Asn Pro Ser His His Leu Tyr Lys Lys Thr 
         575                 580





      <210> 331
      <211> 915
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (6)..(758)

      <400> 331
 ctact    atg ctg cga gaa gac gac aga atg ggg cag ttc ggc ggt ccc      47
          Met Leu Arg Glu Asp Asp Arg Met Gly Gln Phe Gly Gly Pro
            1               5                  10

 gcg ggt ctg tct ctt gct tca aca gtg ttt gga cgg aac aga tcc ggg       95
 Ala Gly Leu Ser Leu Ala Ser Thr Val Phe Gly Arg Asn Arg Ser Gly
  15                  20                  25                  30

 gac tct ctt cca gcc tcc gac cgc cct ccg att tcc tct ccg ctt gca      143
 Asp Ser Leu Pro Ala Ser Asp Arg Pro Pro Ile Ser Ser Pro Leu Ala
                  35                  40                  45

 acc tcc ggg acc atc ttc tcg gcc atc tcc tgc ttc tgg gac ctg cca      191
 Thr Ser Gly Thr Ile Phe Ser Ala Ile Ser Cys Phe Trp Asp Leu Pro
              50                  55                  60

 gca ccg ttt ttg tgg tta gct cct tct tgc caa cca acc atg agc tcc      239
 Ala Pro Phe Leu Trp Leu Ala Pro Ser Cys Gln Pro Thr Met Ser Ser
          65                  70                  75

 cag att cgt cag aat tat tcc acc gac gtg gag gca gcc gtc aac agc      287
 Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala Val Asn Ser
      80                  85                  90

 ctg gtc aat ttg tac ctg cag gcc tcc tac acc tac ctc tct ctg ggc      335
 Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly
  95                 100                 105                 110

 ttc tat ttc gac cgc gat gat gtg gct ctg gaa ggc gtg agc cac ttc      383
 Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val Ser His Phe
                 115                 120                 125

 ttc cgc gaa ctg gcc gag gag aag cgc gag ggc tac gag cgt ctc ctg      431
 Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu
             130                 135                 140

 aag atg caa aac cag cgt ggc ggc cgc gct ctc ttc cag gac atc aag      479
 Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys
         145                 150                 155

 aag cca gct gaa gat gag tgg ggt aaa acc cca gac gcc atg aaa gct      527
 Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met Lys Ala
     160                 165                 170

 gcc atg gcc ctg gag aaa aag ctg aac cag gcc ctt ttg gat ctt cat      575
 Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp Leu His
 175                 180                 185                 190

 gcc ctg ggt tct gcc cgc acg gac ccc cat ctc tgt gac ttc ctg gag      623
 Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe Leu Glu
                 195                 200                 205

 act cac ttc cta gat gag gaa gtg aag ctt atc aag aag atg ggt gac      671
 Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp
             210                 215                 220

 cac ctg acc aac ctc cac agg ctg ggt ggc ccg gag gct ggg ctg ggc      719
 His Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly
         225                 230                 235

 gag tat ctc ttc gaa agg ctc act ctt aag cac gac taa gagccttctg       768
 Glu Tyr Leu Phe Glu Arg Leu Thr Leu Lys His Asp 
     240                 245                 250

 agcccagcga cttctgaagg gccccttgca aagtaatagg gcttctgcta agcctctccc    828

 tccagccaat aggagctttc ttaactatcc taacaagcct tggaccaaat ggaaataaag    888

 ctttttgatg caaaaaaaaa aaaaaac                                        915




      <210> 332
      <211> 1827
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (277)..(1827)

      <400> 332
 atggcaatac tgagggccag agcggccgaa atcctgtttc aggagacagc ggcttcccct     60

 caggctctgc cacgtctcca ggccagacag ggccgggcta aggtccgccg gcgctcccgc    120

 cagtctcccc taaagtcagc gccctggaag ctgagcctgg accacgggac tagggggctc    180

 gcaaacgaca tcggcgtcca gtggcgccgg ccggcccgcc caccttccag ggacaccgtc    240

 cctcggggtc tggctctggc gcctgcaagc catgcc  atg cca tgc cac ccc cct     294
                                          Met Pro Cys His Pro Pro
                                            1               5

 cat aca cgc gcc tcg gag cca cct ggc gct cac ctg ggg acc ggg aaa      342
 His Thr Arg Ala Ser Glu Pro Pro Gly Ala His Leu Gly Thr Gly Lys
              10                  15                  20

 gtg cct gcg tgg tcg ctg aag agt gtg gtg aga tgt gag cag aga cgt      390
 Val Pro Ala Trp Ser Leu Lys Ser Val Val Arg Cys Glu Gln Arg Arg
          25                  30                  35

 gta atg cag cag gcc tgt gct tat ccg gac aga aag aag ggc atg caa      438
 Val Met Gln Gln Ala Cys Ala Tyr Pro Asp Arg Lys Lys Gly Met Gln
      40                  45                  50

 aga ctt aag gat gga gtg tgc tcg gca tgt gcg cag aca aca ggg aag      486
 Arg Leu Lys Asp Gly Val Cys Ser Ala Cys Ala Gln Thr Thr Gly Lys
  55                  60                  65                  70

 cag gac tgt gag aat gct tgg tgt gtc cct tta ata caa gtg gaa act      534
 Gln Asp Cys Glu Asn Ala Trp Cys Val Pro Leu Ile Gln Val Glu Thr
                  75                  80                  85

 gaa cag cca gaa gaa agc ttc cct aac act gaa acc aat ggt gaa ttt      582
 Glu Gln Pro Glu Glu Ser Phe Pro Asn Thr Glu Thr Asn Gly Glu Phe
              90                  95                 100

 ggt aaa tgc cct gca gaa gat atg gaa gag gaa caa gca ttg aaa aga      630
 Gly Lys Cys Pro Ala Glu Asp Met Glu Glu Glu Gln Ala Leu Lys Arg
         105                 110                 115

 tct aga aac act gat gag atg gtt gag tta cac att ctg ctt cag aac      678
 Ser Arg Asn Thr Asp Glu Met Val Glu Leu His Ile Leu Leu Gln Asn
     120                 125                 130

 aag aat tct ggg gca gtt att gga gaa gga ggt aag aat att aag gct      726
 Lys Asn Ser Gly Ala Val Ile Gly Glu Gly Gly Lys Asn Ile Lys Ala
 135                 140                 145                 150

 ccc tgt ata gac tac agt gcc agt gtt tca gtc cca gac agc agt ggc      774
 Pro Cys Ile Asp Tyr Ser Ala Ser Val Ser Val Pro Asp Ser Ser Gly
                 155                 160                 165

 ccc aag tgc ata ctg agt atc agt gct ggt att gaa aca att gga gaa      822
 Pro Lys Cys Ile Leu Ser Ile Ser Ala Gly Ile Glu Thr Ile Gly Glu
             170                 175                 180

 att cta aag aaa atc atc cct acc ttg gaa gag ggc ctc cag ttg cca      870
 Ile Leu Lys Lys Ile Ile Pro Thr Leu Glu Glu Gly Leu Gln Leu Pro
         185                 190                 195

 tta ctc act cca acc agc cag ctc ctg ctg gaa tct gat gct gtg gaa      918
 Leu Leu Thr Pro Thr Ser Gln Leu Leu Leu Glu Ser Asp Ala Val Glu
     200                 205                 210

 tgc tta aat tac caa cac tat aaa gga aga gac ttt gag tgc gag ttg      966
 Cys Leu Asn Tyr Gln His Tyr Lys Gly Arg Asp Phe Glu Cys Glu Leu
 215                 220                 225                 230

 aag ctg ttg att tat cag agt cta gca gga gga ata ttg ggg tca aag     1014
 Lys Leu Leu Ile Tyr Gln Ser Leu Ala Gly Gly Ile Leu Gly Ser Lys
                 235                 240                 245

 gaa tgc tgt tct cat ccc act gac aga gtt gtt ctt att gga gga aaa     1062
 Glu Cys Cys Ser His Pro Thr Asp Arg Val Val Leu Ile Gly Gly Lys
             250                 255                 260

 ccc aat agg gtt gta gag tgc ata aag atc atc ctt gat ctt ata tct     1110
 Pro Asn Arg Val Val Glu Cys Ile Lys Ile Ile Leu Asp Leu Ile Ser
         265                 270                 275

 gag tct ccc atc aaa gga cct gca cag cct tat gat ccc agt ttt tac     1158
 Glu Ser Pro Ile Lys Gly Pro Ala Gln Pro Tyr Asp Pro Ser Phe Tyr
     280                 285                 290

 aat gaa acc tat gat tat ggt ggt ttt aca atg atg ttt gat gac cgc     1206
 Asn Glu Thr Tyr Asp Tyr Gly Gly Phe Thr Met Met Phe Asp Asp Arg
 295                 300                 305                 310

 cct gga tgc cca gtg gga ttt cca atg tgg gga aga ggt ggt ttt gac     1254
 Pro Gly Cys Pro Val Gly Phe Pro Met Trp Gly Arg Gly Gly Phe Asp
                 315                 320                 325

 aga atg cct cct ggt tgg ggt ggg cgt ccc atg cct cca tct aga aga     1302
 Arg Met Pro Pro Gly Trp Gly Gly Arg Pro Met Pro Pro Ser Arg Arg
             330                 335                 340

 gat atg agc cct cat cga gga cca cct cct cct ctt act gga cga ggt     1350
 Asp Met Ser Pro His Arg Gly Pro Pro Pro Pro Leu Thr Gly Arg Gly
         345                 350                 355

 ggc cgg ggt ggt agc aga gct cgg aat ctt cct ctt cct cca cca cca     1398
 Gly Arg Gly Gly Ser Arg Ala Arg Asn Leu Pro Leu Pro Pro Pro Pro
     360                 365                 370

 cca cct aga ggg gaa gac cta atg gcc tat gac aga aga ggg aga cct     1446
 Pro Pro Arg Gly Glu Asp Leu Met Ala Tyr Asp Arg Arg Gly Arg Pro
 375                 380                 385                 390

 gga gac tgt tac gat ggc atg gtt ggt ttc agt cct gat gaa act tgg     1494
 Gly Asp Cys Tyr Asp Gly Met Val Gly Phe Ser Pro Asp Glu Thr Trp
                 395                 400                 405

 aac tct gca ata gat aca tgg agc cca tcg gaa tgg cag atg gct tat     1542
 Asn Ser Ala Ile Asp Thr Trp Ser Pro Ser Glu Trp Gln Met Ala Tyr
             410                 415                 420

 gaa cca cag ggt ggc tcc gga tat gat tat tcc tat gca ggg att ggt     1590
 Glu Pro Gln Gly Gly Ser Gly Tyr Asp Tyr Ser Tyr Ala Gly Ile Gly
         425                 430                 435

 ggc tca tat ggt gat ctt ggt gga cct att act act gca caa gta act     1638
 Gly Ser Tyr Gly Asp Leu Gly Gly Pro Ile Thr Thr Ala Gln Val Thr
     440                 445                 450

 att ccc aaa gat ttg act gga tct att att ggc aaa ggt ggt cag cgg     1686
 Ile Pro Lys Asp Leu Thr Gly Ser Ile Ile Gly Lys Gly Gly Gln Arg
 455                 460                 465                 470

 att aaa caa atc ggt cat gag ttg gga gct tca atc aaa att gat gag     1734
 Ile Lys Gln Ile Gly His Glu Leu Gly Ala Ser Ile Lys Ile Asp Glu
                 475                 480                 485

 cct tta gaa gga tcc gaa gat cag atc act atc att aca gga aca cag     1782
 Pro Leu Glu Gly Ser Glu Asp Gln Ile Thr Ile Ile Thr Gly Thr Gln
             490                 495                 500

 gac cag ata cag aat gca caa tat ttg ctg cag aac aat gtg tag         1827
 Asp Gln Ile Gln Asn Ala Gln Tyr Leu Leu Gln Asn Asn Val 
         505                 510                 515





      <210> 333
      <211> 783
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(783)

      <400> 333
  atg acc cag acc ccg cgc ggg gcg tca agc gca ggc gca cta ccg ccc      48
  Met Thr Gln Thr Pro Arg Gly Ala Ser Ser Ala Gly Ala Leu Pro Pro
    1               5                  10                  15

 aca agc tgg agc ccg gct tcg ggg cgg ggc gag ggt cag tca cgt ggg       96
 Thr Ser Trp Ser Pro Ala Ser Gly Arg Gly Glu Gly Gln Ser Arg Gly
              20                  25                  30

 ccc gca gcc ctc tcc tcg att tcc cta caa gga ctt ggg ccg acg ggc      144
 Pro Ala Ala Leu Ser Ser Ile Ser Leu Gln Gly Leu Gly Pro Thr Gly
          35                  40                  45

 ccc gcc ctt cgc cgt gcc ctg gaa tgt gcg gcc agg caa agc cac agg      192
 Pro Ala Leu Arg Arg Ala Leu Glu Cys Ala Ala Arg Gln Ser His Arg
      50                  55                  60

 acg gac gca acc atc tgc gga aag gat agg ggg gag gaa gac tta aca      240
 Thr Asp Ala Thr Ile Cys Gly Lys Asp Arg Gly Glu Glu Asp Leu Thr
  65                  70                  75                  80

 ctg caa caa cag gac tta acc acc acc atg tcg agc aaa aga aca aag      288
 Leu Gln Gln Gln Asp Leu Thr Thr Thr Met Ser Ser Lys Arg Thr Lys
                  85                  90                  95

 acc aag acc aag aag cgc cct cag cgt gca aca tcc aat gtg ttt gct      336
 Thr Lys Thr Lys Lys Arg Pro Gln Arg Ala Thr Ser Asn Val Phe Ala
             100                 105                 110

 atg ttt gac cag tca cag att cag gag ttc aaa gag gcc ttc aac atg      384
 Met Phe Asp Gln Ser Gln Ile Gln Glu Phe Lys Glu Ala Phe Asn Met
         115                 120                 125

 att gat cag aac aga gat ggc ttc atc gac aag gaa gat ttg cat gat      432
 Ile Asp Gln Asn Arg Asp Gly Phe Ile Asp Lys Glu Asp Leu His Asp
     130                 135                 140

 atg ctt gct tct cta ggg aag aat ccc act gat gca tac ctt gat gcc      480
 Met Leu Ala Ser Leu Gly Lys Asn Pro Thr Asp Ala Tyr Leu Asp Ala
 145                 150                 155                 160

 atg atg aat gag gcc cca ggg ccc atc aat ttc acc atg ttc ctg acc      528
 Met Met Asn Glu Ala Pro Gly Pro Ile Asn Phe Thr Met Phe Leu Thr
                 165                 170                 175

 atg ttt ggt gag aag tta aat ggc aca gat cct gaa gat gtc atc aga      576
 Met Phe Gly Glu Lys Leu Asn Gly Thr Asp Pro Glu Asp Val Ile Arg
             180                 185                 190

 aac gcc ttt gct tgc ttt gat gaa gaa gca aca ggc acc att cag gaa      624
 Asn Ala Phe Ala Cys Phe Asp Glu Glu Ala Thr Gly Thr Ile Gln Glu
         195                 200                 205

 gat tac cta aga gag ctg ctg aca acc atg ggg gat cgg ttt aca gat      672
 Asp Tyr Leu Arg Glu Leu Leu Thr Thr Met Gly Asp Arg Phe Thr Asp
     210                 215                 220

 gag gaa gtg gat gag ctg tac aga gaa gca cct att gac aaa aag ggg      720
 Glu Glu Val Asp Glu Leu Tyr Arg Glu Ala Pro Ile Asp Lys Lys Gly
 225                 230                 235                 240

 aat ttc aat tac atc gag ttc aca cgc atc ctg aaa cat gga gcc aaa      768
 Asn Phe Asn Tyr Ile Glu Phe Thr Arg Ile Leu Lys His Gly Ala Lys
                 245                 250                 255

 gac aaa gat gac tga                                                  783
 Asp Lys Asp Asp 
             260





      <210> 334
      <211> 1098
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (43)..(846)

      <400> 334
 ggcgcctcac gtcggactcc gtctccgcgg cagggaagca gc   atg gaa gct gag      54
                                                  Met Glu Ala Glu
                                                    1

 gac atc cag gag gag ttg acc tgc ccc atc tgc ctg gac tat ttc cag      102
 Asp Ile Gln Glu Glu Leu Thr Cys Pro Ile Cys Leu Asp Tyr Phe Gln
   5                  10                  15                  20

 gac ccg gtg tcc atc gag tgc ggc cac aac ttc tgc cgc ggc tgc ctg      150
 Asp Pro Val Ser Ile Glu Cys Gly His Asn Phe Cys Arg Gly Cys Leu
                  25                  30                  35

 cac cgc aac tgg gcg ccg ggc ggc ggc ccg ttc ccc tgc ccc gaa tgt      198
 His Arg Asn Trp Ala Pro Gly Gly Gly Pro Phe Pro Cys Pro Glu Cys
              40                  45                  50

 cgg cac cca tcg gcg ccc gcc gcg ctg cga ccc aac tgg gcc ctg gcc      246
 Arg His Pro Ser Ala Pro Ala Ala Leu Arg Pro Asn Trp Ala Leu Ala
          55                  60                  65

 agg ctg act gag aag acg cag cgc cgg cgc ctg ggc ccc gtg ccc ccg      294
 Arg Leu Thr Glu Lys Thr Gln Arg Arg Arg Leu Gly Pro Val Pro Pro
      70                  75                  80

 ggc ctg tgc ggc cgc cac tgg gag ccg ctg cgg ctc ttc tgc gag gac      342
 Gly Leu Cys Gly Arg His Trp Glu Pro Leu Arg Leu Phe Cys Glu Asp
  85                  90                  95                 100

 gac cag cgg cca gtg tgc ctg gtg tgc agg gag tcc cag gag cac cag      390
 Asp Gln Arg Pro Val Cys Leu Val Cys Arg Glu Ser Gln Glu His Gln
                 105                 110                 115

 act cac gcc atg gca ccc atc gac gag gcc ttc gag agc tac cgg gag      438
 Thr His Ala Met Ala Pro Ile Asp Glu Ala Phe Glu Ser Tyr Arg Glu
             120                 125                 130

 aaa ctt ctt aag tct cag cgt aat ctc gtg gcc aag atg aag aaa gtc      486
 Lys Leu Leu Lys Ser Gln Arg Asn Leu Val Ala Lys Met Lys Lys Val
         135                 140                 145

 atg cat tta cag gat gta gaa gtg aag aac gcc aca cag tgg aag gat      534
 Met His Leu Gln Asp Val Glu Val Lys Asn Ala Thr Gln Trp Lys Asp
     150                 155                 160

 aag ata aag agt cag cga atg aga atc agc acg gag ttt tca aag ctg      582
 Lys Ile Lys Ser Gln Arg Met Arg Ile Ser Thr Glu Phe Ser Lys Leu
 165                 170                 175                 180

 cac aac ttc ctg gtt gaa gaa gag gac ctg ttt ctt cag aga ttg aac      630
 His Asn Phe Leu Val Glu Glu Glu Asp Leu Phe Leu Gln Arg Leu Asn
                 185                 190                 195

 aaa gaa gaa gaa gag acg aag aag aag ctg aat gag aac acg tta aaa      678
 Lys Glu Glu Glu Glu Thr Lys Lys Lys Leu Asn Glu Asn Thr Leu Lys
             200                 205                 210

 ctc aat caa act atc gct tca ttg aag aag ctc atc tta gag gtg ggg      726
 Leu Asn Gln Thr Ile Ala Ser Leu Lys Lys Leu Ile Leu Glu Val Gly
         215                 220                 225

 gag aag agc cag gct ccc acc ctg gag ctg ctt cag gtg aga cag tta      774
 Glu Lys Ser Gln Ala Pro Thr Leu Glu Leu Leu Gln Val Arg Gln Leu
     230                 235                 240

 cga gtg ggg gtg atc tca tct tca cta act gaa ctc tct ctt gtc ttt      822
 Arg Val Gly Val Ile Ser Ser Ser Leu Thr Glu Leu Ser Leu Val Phe
 245                 250                 255                 260

 aga gct gaa tgt cct tcc tgg tga gtgggtttca tagacatgtc ttatctcttg     876
 Arg Ala Glu Cys Pro Ser Trp 
                 265

 ctagttctgt gctgtcacat aactaaaaag ccaaagattc accattcaaa ggaaattaat    936

 gtgaaatgta ggtatgctga gctcagctca taggagataa gttgattcac acagtctcat    996

 agttcatcta ggatctgaga cttagcacat ataagatttt tttcattcat cttatgtgta   1056

 catttataat tattaaacaa taaaacaaag caagcataaa ac                      1098




      <210> 335
      <211> 1249
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (215)..(1195)

      <400> 335
 ccgtgcccag ctcatcggag gtcactgcag tcagctctgc agcatgccag acccttgtgc     60

 ctcggtcttc ccggccaggt gtgggagccc cacctgtgtg gccacccagc ctccacagca    120

 gctgcccact ccgggtctcc cagccataca cgcagccatc ttctgagcct gtgagcagca    180

 tctggccatc aggggagaag gcagaagagt tgac    atg aac agc ggg gtc ccg     232
                                          Met Asn Ser Gly Val Pro
                                            1               5

 gcc acg ctg gcc gtg cgg aga gtg aaa ttc ttc ggc cag cac ggc ggg      280
 Ala Thr Leu Ala Val Arg Arg Val Lys Phe Phe Gly Gln His Gly Gly
              10                  15                  20

 gag gtc aac tct tct gcc ttc tcc cct gat ggc cag atg ctg ctc aca      328
 Glu Val Asn Ser Ser Ala Phe Ser Pro Asp Gly Gln Met Leu Leu Thr
          25                  30                  35

 ggc tca gaa gat ggc tgc gtg tat ggc tgg gag acc cgg agt ggg cag      376
 Gly Ser Glu Asp Gly Cys Val Tyr Gly Trp Glu Thr Arg Ser Gly Gln
      40                  45                  50

 ctg ctg tgg agg ctg ggt ggc cac aca ggc ccc gtg aag ttc tgc cgc      424
 Leu Leu Trp Arg Leu Gly Gly His Thr Gly Pro Val Lys Phe Cys Arg
  55                  60                  65                  70

 ttc tcc cct gat ggc cac ctc ttc gcc agc gcc tcc tgt gac tgc act      472
 Phe Ser Pro Asp Gly His Leu Phe Ala Ser Ala Ser Cys Asp Cys Thr
                  75                  80                  85

 gtc cgc ctg tgg gat gtg gca aga gcg aag tgt ctg cgg gtc ctg aag      520
 Val Arg Leu Trp Asp Val Ala Arg Ala Lys Cys Leu Arg Val Leu Lys
              90                  95                 100

 ggt cac caa cgg agt gtg gag acg gtc agc ttc agc cct gac tcg aga      568
 Gly His Gln Arg Ser Val Glu Thr Val Ser Phe Ser Pro Asp Ser Arg
         105                 110                 115

 cag ctg gca tca ggt ggc tgg gac aag cgg gtg atg ctc tgg gat gtg      616
 Gln Leu Ala Ser Gly Gly Trp Asp Lys Arg Val Met Leu Trp Asp Val
     120                 125                 130

 cag tgg ccc cat acc cac ttg gag ctg agt ggt ggg aag ggg atg gac      664
 Gln Trp Pro His Thr His Leu Glu Leu Ser Gly Gly Lys Gly Met Asp
 135                 140                 145                 150

 tct ggg tcc cgc cta gat gca gag tgg gtg gag agc tgg ctg ggc cag      712
 Ser Gly Ser Arg Leu Asp Ala Glu Trp Val Glu Ser Trp Leu Gly Gln
                 155                 160                 165

 act cac aga agc tgc ctg cag gcc acc ggc tcc tgg gac tcc acc gta      760
 Thr His Arg Ser Cys Leu Gln Ala Thr Gly Ser Trp Asp Ser Thr Val
             170                 175                 180

 cgc atc tgg gac ctg cgg atg gtg acc cca gca gtc tcc cac cag gcg      808
 Arg Ile Trp Asp Leu Arg Met Val Thr Pro Ala Val Ser His Gln Ala
         185                 190                 195

 cta gag gga cac agt ggc aac atc agc tgc ctg tgc tat tca gca tcc      856
 Leu Glu Gly His Ser Gly Asn Ile Ser Cys Leu Cys Tyr Ser Ala Ser
     200                 205                 210

 ggc ctc ctg gca tcc ggc tcc tgg gac aag acc atc cac atc tgg aag      904
 Gly Leu Leu Ala Ser Gly Ser Trp Asp Lys Thr Ile His Ile Trp Lys
 215                 220                 225                 230

 ccc aca acc agc agc ctg ctt atc caa ctg aag ggc cat gtc acc tgg      952
 Pro Thr Thr Ser Ser Leu Leu Ile Gln Leu Lys Gly His Val Thr Trp
                 235                 240                 245

 gtg aag agc ata gcc ttc tct ccc gac gag ctg tgg ctg gcc agc gcc     1000
 Val Lys Ser Ile Ala Phe Ser Pro Asp Glu Leu Trp Leu Ala Ser Ala
             250                 255                 260

 ggc tat tcc cgc atg gtc aaa gtc tgg gac tgc aac aca gga aag tgc     1048
 Gly Tyr Ser Arg Met Val Lys Val Trp Asp Cys Asn Thr Gly Lys Cys
         265                 270                 275

 ctt gag acc ctg aag cag gga gtc ctg gat gtg gcc cac acc tgt gcc     1096
 Leu Glu Thr Leu Lys Gln Gly Val Leu Asp Val Ala His Thr Cys Ala
     280                 285                 290

 ttc acc cca gat ggg aaa atc tta gtg tct gga gct gcc gat cag act     1144
 Phe Thr Pro Asp Gly Lys Ile Leu Val Ser Gly Ala Ala Asp Gln Thr
 295                 300                 305                 310

 aga cgt caa ata tcc cgc acg tcc aaa tca ccc agg gac cct caa acc     1192
 Arg Arg Gln Ile Ser Arg Thr Ser Lys Ser Pro Arg Asp Pro Gln Thr
                 315                 320                 325

 taa cacc aaccacctca gatggtgccg acctcacccg ctcccctcag tggcgcacag     1249
 






      <210> 336
      <211> 1218
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (55)..(1218)

      <400> 336
 atgacgggtc ggcaaagcct gagtcctgtc ctctcactct cctccctgga tagc  atg      57
                                                              Met
                                                                1

 agc ttc acc act cgc tcc atc ttc tcc acc aac tac ctg ttc ctg ggc      105
 Ser Phe Thr Thr Arg Ser Ile Phe Ser Thr Asn Tyr Leu Phe Leu Gly
               5                  10                  15

 tct gtc cag gtg tcc aac tac ggc gcc cgg ccg gcc agc tgc atg gcc      153
 Ser Val Gln Val Ser Asn Tyr Gly Ala Arg Pro Ala Ser Cys Met Ala
          20                  25                  30

 agc gtc tat gca ggc gcc ggg ggc tct ggt tcc cgg ata tcc gtg tcc      201
 Ser Val Tyr Ala Gly Ala Gly Gly Ser Gly Ser Arg Ile Ser Val Ser
      35                  40                  45

 cgc tcc acc agc ttc cgg ggt ggc atg ggg tcc ggg gac ctg gcc gcg      249
 Arg Ser Thr Ser Phe Arg Gly Gly Met Gly Ser Gly Asp Leu Ala Ala
  50                  55                  60                  65

 ggg atg gcc ggg ggt ctg gca gga atg gga ggc atc cag aat aag aag      297
 Gly Met Ala Gly Gly Leu Ala Gly Met Gly Gly Ile Gln Asn Lys Lys
                  70                  75                  80

 gag aca atg caa agc ctg aat gac cgt ctg gcc tcc tac ctg gac aga      345
 Glu Thr Met Gln Ser Leu Asn Asp Arg Leu Ala Ser Tyr Leu Asp Arg
              85                  90                  95

 gtg agg agc ctg gag acc aag aac cgg aag ctg gag agc aaa atc cgg      393
 Val Arg Ser Leu Glu Thr Lys Asn Arg Lys Leu Glu Ser Lys Ile Arg
         100                 105                 110

 gag cac ctg gag aag aag gga ctc cag gtc aga gac tgg agt cat tac      441
 Glu His Leu Glu Lys Lys Gly Leu Gln Val Arg Asp Trp Ser His Tyr
     115                 120                 125

 ctc aag acc atc gag gac ctg agg gtt cag atc ttc gca aat act gtg      489
 Leu Lys Thr Ile Glu Asp Leu Arg Val Gln Ile Phe Ala Asn Thr Val
 130                 135                 140                 145

 gac aat gcc ggc atc gtt ttg cag att gac aat gcc tgt ctt gca gcc      537
 Asp Asn Ala Gly Ile Val Leu Gln Ile Asp Asn Ala Cys Leu Ala Ala
                 150                 155                 160

 gat gac ttt aga gtc aag tca ctg atg acc aat gtc act tgg ctg cca      585
 Asp Asp Phe Arg Val Lys Ser Leu Met Thr Asn Val Thr Trp Leu Pro
             165                 170                 175

 ctg gag aca gag atg gag gct ctc aag gag gag ctg ctc ttc atg aag      633
 Leu Glu Thr Glu Met Glu Ala Leu Lys Glu Glu Leu Leu Phe Met Lys
         180                 185                 190

 aag aac cac gaa gag gaa gta aaa gac cta caa gcc cag att acc agc      681
 Lys Asn His Glu Glu Glu Val Lys Asp Leu Gln Ala Gln Ile Thr Ser
     195                 200                 205

 tct ggg ttg acc atg gag ctg cct cag aag agc cga gag gag cca gac      729
 Ser Gly Leu Thr Met Glu Leu Pro Gln Lys Ser Arg Glu Glu Pro Asp
 210                 215                 220                 225

 aag tac tgc tct cag cag atg gag gag agc acc aca gtg gtc acc atg      777
 Lys Tyr Cys Ser Gln Gln Met Glu Glu Ser Thr Thr Val Val Thr Met
                 230                 235                 240

 cag tct gcc aag gtt gga gct gct gag atg atg ctc atg aaa ctg aga      825
 Gln Ser Ala Lys Val Gly Ala Ala Glu Met Met Leu Met Lys Leu Arg
             245                 250                 255

 cgt aca gtc cag tcc ttg gag att gac ctg gac tcc atg aga aat ctg      873
 Arg Thr Val Gln Ser Leu Glu Ile Asp Leu Asp Ser Met Arg Asn Leu
         260                 265                 270

 aag gtc agc ttg gga aac agc ctg agg gag gtg gag gcc cac tac acc      921
 Lys Val Ser Leu Gly Asn Ser Leu Arg Glu Val Glu Ala His Tyr Thr
     275                 280                 285

 ctg cag atg gag cag ctc aat ggg atc ctg ctg cac ctg gaa tca gag      969
 Leu Gln Met Glu Gln Leu Asn Gly Ile Leu Leu His Leu Glu Ser Glu
 290                 295                 300                 305

 ctg gca cag acc cag gca gag gga cag tgc cag gcc cag gag tac aag     1017
 Leu Ala Gln Thr Gln Ala Glu Gly Gln Cys Gln Ala Gln Glu Tyr Lys
                 310                 315                 320

 gcc ctg ctg aac atc aag ctc aag ctg gag gct gag atc acc acc tac     1065
 Ala Leu Leu Asn Ile Lys Leu Lys Leu Glu Ala Glu Ile Thr Thr Tyr
             325                 330                 335

 cac tgc ctg ctg gaa gat ggc aag gac ttc aat ctt ggt gat gcc ctg     1113
 His Cys Leu Leu Glu Asp Gly Lys Asp Phe Asn Leu Gly Asp Ala Leu
         340                 345                 350

 gac agc agc aac tcc atg caa atc atc caa aag aac act acc cac tgg     1161
 Asp Ser Ser Asn Ser Met Gln Ile Ile Gln Lys Asn Thr Thr His Trp
     355                 360                 365

 ata gtg gat ggc aaa gtg gtg tct gag aat aat gac acc aaa gtt ctg     1209
 Ile Val Asp Gly Lys Val Val Ser Glu Asn Asn Asp Thr Lys Val Leu
 370                 375                 380                 385

 aga cat taa                                                         1218
 Arg His 






      <210> 337
      <211> 2817
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (448)..(2175)

      <220>
      <221> misc_feature
      <222> (1)...(2817)
      <223> n = a,t,c or g

      <400> 337
 acaccgagcc gggcgcttag cagcaacgnc ctcttntcgg ctncaggtct tccccttcac     60

 aactgatccc tgttggggat ttntntttta ctaattggga acggtgggga gagccaggga    120

 ggggggacct ggagaagggg agagattagg cagccatcaa tttcctccag tatctcccag    180

 aacaggtgat gcttctaaat tgtgatcact ttcaggaggc agcactgcag ctggaaggat    240

 gcgagcgacc tagggtggag tggctgaggc ggcagatctg aacttgcgga ggataagaac    300

 ccaaactttt ctaagactca aatttgggca cttgatccct tttcttggat tgctttggag    360

 gagacgattt gctggcaacg ttgggaacag tcaggactgt gttgtaactc ttacttttaa    420

 agcgacagta gggatcagac tttttaa    atg ttt gga att caa gat act tta     471
                                  Met Phe Gly Ile Gln Asp Thr Leu
                                    1               5

 gga aga gga cca act ctg aaa gag aaa tcg ctg ggc gcg gag atg gat      519
 Gly Arg Gly Pro Thr Leu Lys Glu Lys Ser Leu Gly Ala Glu Met Asp
      10                  15                  20

 tcg gtc agg tcc tgg gtc cgg aat gtc gga gtg gtg gac gct aat gtc      567
 Ser Val Arg Ser Trp Val Arg Asn Val Gly Val Val Asp Ala Asn Val
  25                  30                  35                  40

 gcc gcg cag agc ggg gtc gcc ctg tcc cgg gcc cac ttt gag aaa cag      615
 Ala Ala Gln Ser Gly Val Ala Leu Ser Arg Ala His Phe Glu Lys Gln
                  45                  50                  55

 cct cct tcc aac ttg agg aaa tcc aac ttc ttt cac ttc gtc ctg gcg      663
 Pro Pro Ser Asn Leu Arg Lys Ser Asn Phe Phe His Phe Val Leu Ala
              60                  65                  70

 ctc tat gac agg cag ggc cag ccg gtg gag atc gag cgg acg gcc ttc      711
 Leu Tyr Asp Arg Gln Gly Gln Pro Val Glu Ile Glu Arg Thr Ala Phe
          75                  80                  85

 gtg gac ttt gtg gag aat gac aaa gaa caa ggc aac gag aag acc aac      759
 Val Asp Phe Val Glu Asn Asp Lys Glu Gln Gly Asn Glu Lys Thr Asn
      90                  95                 100

 aac ggc act cac tac aag tta cag ctc ctc tac agc aac ggt gtc cgc      807
 Asn Gly Thr His Tyr Lys Leu Gln Leu Leu Tyr Ser Asn Gly Val Arg
 105                 110                 115                 120

 acg gaa cag gac ctc tat gtc agg ctc atc gac tcg gtc acc aag cag      855
 Thr Glu Gln Asp Leu Tyr Val Arg Leu Ile Asp Ser Val Thr Lys Gln
                 125                 130                 135

 ccc atc gct tac ggg gga cag aat aag aat ccg gaa atg tgc cga gtt      903
 Pro Ile Ala Tyr Gly Gly Gln Asn Lys Asn Pro Glu Met Cys Arg Val
             140                 145                 150

 ctc ctg acg cac gaa gtg atg tgt agt cga tgc tgc gaa aag aaa agc      951
 Leu Leu Thr His Glu Val Met Cys Ser Arg Cys Cys Glu Lys Lys Ser
         155                 160                 165

 tgt gga aac cga aat gag act cca tcg gac cca gtc ata att gac aga      999
 Cys Gly Asn Arg Asn Glu Thr Pro Ser Asp Pro Val Ile Ile Asp Arg
     170                 175                 180

 ttc ttt tta aaa ttt ttc ctc aag tgc aat cag aat tgt ttg aaa aca     1047
 Phe Phe Leu Lys Phe Phe Leu Lys Cys Asn Gln Asn Cys Leu Lys Thr
 185                 190                 195                 200

 gca gga aac cca agg gac atg aga cgg ttt cag gtt gtg ttg tca aca     1095
 Ala Gly Asn Pro Arg Asp Met Arg Arg Phe Gln Val Val Leu Ser Thr
                 205                 210                 215

 acg gtg aat gtg gat gga cac gtc ctg gct gtt tct gac aac atg ttt     1143
 Thr Val Asn Val Asp Gly His Val Leu Ala Val Ser Asp Asn Met Phe
             220                 225                 230

 gtt cat aac aac tcc aag cat gga cgg aga gca aga aga ctc gat cca     1191
 Val His Asn Asn Ser Lys His Gly Arg Arg Ala Arg Arg Leu Asp Pro
         235                 240                 245

 tcg gaa gct acc ccc tgc atc aaa gcc att agc ccg agt gaa ggc tgg     1239
 Ser Glu Ala Thr Pro Cys Ile Lys Ala Ile Ser Pro Ser Glu Gly Trp
     250                 255                 260

 acc aca gga gga gcc atg gtc atc atc atc ggg gac aac ttc ttt gat     1287
 Thr Thr Gly Gly Ala Met Val Ile Ile Ile Gly Asp Asn Phe Phe Asp
 265                 270                 275                 280

 ggt ctc caa gtg gtg ttt ggg act atg ctt gta tgg agc gag cta ata     1335
 Gly Leu Gln Val Val Phe Gly Thr Met Leu Val Trp Ser Glu Leu Ile
                 285                 290                 295

 acc cct cat gcc atc aga gta cag act cct ccc cgg cac atc cca ggc     1383
 Thr Pro His Ala Ile Arg Val Gln Thr Pro Pro Arg His Ile Pro Gly
             300                 305                 310

 gtg gta gag gtg aca tta tct tat aaa tct aaa cag ttc tgc aaa gga     1431
 Val Val Glu Val Thr Leu Ser Tyr Lys Ser Lys Gln Phe Cys Lys Gly
         315                 320                 325

 gcc cca gga agg ttc att tac aca gca tta aat gaa ccc acc ata gac     1479
 Ala Pro Gly Arg Phe Ile Tyr Thr Ala Leu Asn Glu Pro Thr Ile Asp
     330                 335                 340

 tat ggc ttc cag aga ctg cag aag gtc atc cct agg cat cct gga gat     1527
 Tyr Gly Phe Gln Arg Leu Gln Lys Val Ile Pro Arg His Pro Gly Asp
 345                 350                 355                 360

 cct gag aga tta gct aag gag atg ctg ttg aaa aga gct gca gat cta     1575
 Pro Glu Arg Leu Ala Lys Glu Met Leu Leu Lys Arg Ala Ala Asp Leu
                 365                 370                 375

 gtg gaa gct ctt tat ggc aca cca cac aat aac cag gac atc att ttg     1623
 Val Glu Ala Leu Tyr Gly Thr Pro His Asn Asn Gln Asp Ile Ile Leu
             380                 385                 390

 aag cga gcc gca gac att gct gaa gct ctc tac agc gtc ccc agg aat     1671
 Lys Arg Ala Ala Asp Ile Ala Glu Ala Leu Tyr Ser Val Pro Arg Asn
         395                 400                 405

 ccc agc cag ctt cca gcc ctc tct agc tcc cca gcg cac agt ggc atg     1719
 Pro Ser Gln Leu Pro Ala Leu Ser Ser Ser Pro Ala His Ser Gly Met
     410                 415                 420

 atg gga atc aac tcc tat ggc agc cag ctt ggg gtc agc atc tca gag     1767
 Met Gly Ile Asn Ser Tyr Gly Ser Gln Leu Gly Val Ser Ile Ser Glu
 425                 430                 435                 440

 tca aca caa gga aat aat caa ggg tac atc cgc aac aca agc agc atc     1815
 Ser Thr Gln Gly Asn Asn Gln Gly Tyr Ile Arg Asn Thr Ser Ser Ile
                 445                 450                 455

 tct ccg cgg gga tac tct tcc agc tcc acg cct caa cag tct aat tac     1863
 Ser Pro Arg Gly Tyr Ser Ser Ser Ser Thr Pro Gln Gln Ser Asn Tyr
             460                 465                 470

 agt acc tcc agc aac agt atg aat ggc tac agc aat gtc ccc atg gcc     1911
 Ser Thr Ser Ser Asn Ser Met Asn Gly Tyr Ser Asn Val Pro Met Ala
         475                 480                 485

 aac ttg ggt gtt cca ggt tca cca gga ttt cta aat ggc tca ccc acc     1959
 Asn Leu Gly Val Pro Gly Ser Pro Gly Phe Leu Asn Gly Ser Pro Thr
     490                 495                 500

 ggc tct cct tat gga atc atg tca tcg agt ccc acc gtt ggg tct tcc     2007
 Gly Ser Pro Tyr Gly Ile Met Ser Ser Ser Pro Thr Val Gly Ser Ser
 505                 510                 515                 520

 agc aca tcc tcc atc ctc cca ttt tcc tct tca gtt ttt cct gct gtc     2055
 Ser Thr Ser Ser Ile Leu Pro Phe Ser Ser Ser Val Phe Pro Ala Val
                 525                 530                 535

 aaa cag aag agt gcc ttt gcc cct gtc atc agg ccc caa ggc tcc cct     2103
 Lys Gln Lys Ser Ala Phe Ala Pro Val Ile Arg Pro Gln Gly Ser Pro
             540                 545                 550

 tca cct gcc tgc tcc agc ggc aat gga aat gga ttc aga gcc atg acc     2151
 Ser Pro Ala Cys Ser Ser Gly Asn Gly Asn Gly Phe Arg Ala Met Thr
         555                 560                 565

 gga ctt gtt gta ccc ccg atg taa agaagaactg ctttcttata gcacaaaact    2205
 Gly Leu Val Val Pro Pro Met 
     570                 575

 acttactctg atggaccaat aatgaagaaa gcactaggag ctcttttggg ggtgtagtgg   2265

 tgcccccaca tgaacatgat ggacaccctt gggtctgcaa ggagccagca tcttacttgg   2325

 tcccacgtcc tcctatagct ctgatggtgg ctacacaaac tgaccctctt gggacaagga   2385

 caaaagatgt cattgacgta gtcagtgcta agagcagaaa tgcaattctt tgttatgaac   2445

 attatgaaaa ccaccttcct atgtttgtaa aatatttaag aaaaaattgg caaacaatta   2505

 atgcttaata ttttggatac tatttgtttt tctttgtagg aaaaaaaagt tgaaagtttc   2565

 tattttctat gaagcctttc agataccaat ttagtttatg cagaaaaaaa ttgaacaaaa   2625

 cagggtacca gcacggaaga ctttcttaaa acgcaacctg aattgaatga tgaaatgttg   2685

 tatgtgtgtt tgcttatagc ttaatctctt taaaaaatga acaaaaaaag ggaaaaattt   2745

 taaaatgttt tacaattatt taaataaata aatgtgtaac ttattgtaaa aaaaaaaaaa   2805

 aaaaaaaaat tg                                                       2817




      <210> 338
      <211> 615
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(615)

      <400> 338
  atg gcc acc agg gtc cgg aca gct tct att tgg gtc cca cct ctc caa      48
  Met Ala Thr Arg Val Arg Thr Ala Ser Ile Trp Val Pro Pro Leu Gln
    1               5                  10                  15

 gaa cga aac agt tca tgg gat agg atc aga aag ctc caa ggt cag gaa       96
 Glu Arg Asn Ser Ser Trp Asp Arg Ile Arg Lys Leu Gln Gly Gln Glu
              20                  25                  30

 tcc atc ttg ggc caa ggg act cct ggt ctg caa cct ctc cct gga aca      144
 Ser Ile Leu Gly Gln Gly Thr Pro Gly Leu Gln Pro Leu Pro Gly Thr
          35                  40                  45

 ccc agg cag aag cag aag agt cgc aga ata gag aaa gtc cta gag tgg      192
 Pro Arg Gln Lys Gln Lys Ser Arg Arg Ile Glu Lys Val Leu Glu Trp
      50                  55                  60

 ctg ttt att tcc caa gag cag cca aaa atc acc aag tcc tgg gga cct      240
 Leu Phe Ile Ser Gln Glu Gln Pro Lys Ile Thr Lys Ser Trp Gly Pro
  65                  70                  75                  80

 ttg tca ttc atg gat gtg ttt gtg gat ttt acc tgg gag gag tgg cag      288
 Leu Ser Phe Met Asp Val Phe Val Asp Phe Thr Trp Glu Glu Trp Gln
                  85                  90                  95

 ctg cta gac cca gca cag aag tgc ctg tac agg agt gtg atg ttg gag      336
 Leu Leu Asp Pro Ala Gln Lys Cys Leu Tyr Arg Ser Val Met Leu Glu
             100                 105                 110

 aac tat agc aac ctg gtg tcc cta ggg tac caa cac acc aaa cct gat      384
 Asn Tyr Ser Asn Leu Val Ser Leu Gly Tyr Gln His Thr Lys Pro Asp
         115                 120                 125

 atc atc ttc aag ttg gaa caa gga gaa gag ctg tgt ttg gtg cag gcc      432
 Ile Ile Phe Lys Leu Glu Gln Gly Glu Glu Leu Cys Leu Val Gln Ala
     130                 135                 140

 caa gtt cca aat cag acc tgt cca att ttg aag gct gga aag tcc aaa      480
 Gln Val Pro Asn Gln Thr Cys Pro Ile Leu Lys Ala Gly Lys Ser Lys
 145                 150                 155                 160

 gcc aag gtg ctg gca ggt ttg gtg tct ggt gag ggc ctg ctc tgt gct      528
 Ala Lys Val Leu Ala Gly Leu Val Ser Gly Glu Gly Leu Leu Cys Ala
                 165                 170                 175

 tcc aag atg acg cct tgc ttg ctg cat cct ctg gag aca cag tct gga      576
 Ser Lys Met Thr Pro Cys Leu Leu His Pro Leu Glu Thr Gln Ser Gly
             180                 185                 190

 aaa ttg atg act ctt atg gat tgg cat cag gac aaa taa                  615
 Lys Leu Met Thr Leu Met Asp Trp His Gln Asp Lys 
         195                 200





      <210> 339
      <211> 1159
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (463)..(993)

      <400> 339
 atgaataggt ggccaccaga ctgtgggaag agaaaagcat tcggagtaga aagaacagct     60

 aagcggagga gtagagatga aatcgggtcc agtgtgtcga gaattcgaca ggggtgggac    120

 agagatggag agctgggagc tggcacagtg gaaagggtaa gccaagagga gcaactgagc    180

 tacggcagcg tcacctggga tggaggccca caggtctatg atggagcctt cgccacccat    240

 tttgcagatt gggaaacgca ggttcagaga gctgaaatga catgttccag ttcacaaacc    300

 catgggatca aacccctaac ccatgtgttt cttccatatc gcctttccac agtgggtggt    360

 ctggccctaa ccgctcccgc atccctcgcc tgcacagtgg gcagtctggc gcctgtggcg    420

 tcgtgtttgc tgagggcccg gctgccgttg actgaggctg cg   atg gcg gcg gca     474
                                                  Met Ala Ala Ala
                                                    1

 ggc cgg ggt cgg gag cag gac tcg gcg cgc ttc gtc tat gtg acg cgc      522
 Gly Arg Gly Arg Glu Gln Asp Ser Ala Arg Phe Val Tyr Val Thr Arg
   5                  10                  15                  20

 ttc ggc tcg cat cag tgc agt ggc gtc ctg caa ctg ggc ggc cgt gga      570
 Phe Gly Ser His Gln Cys Ser Gly Val Leu Gln Leu Gly Gly Arg Gly
                  25                  30                  35

 gct caa ggc ctt tgg ggt cag ggg cct ggg gca ggc tgt cgc cag gag      618
 Ala Gln Gly Leu Trp Gly Gln Gly Pro Gly Ala Gly Cys Arg Gln Glu
              40                  45                  50

 aag ccg agg gaa gca atg gcg gtg gcg ggc gtt cag ggt ggc agc gag      666
 Lys Pro Arg Glu Ala Met Ala Val Ala Gly Val Gln Gly Gly Ser Glu
          55                  60                  65

 ctg ccc ctc ggt tcc cag ctc agg gtc ccc acg acc cct ggt gtg gag      714
 Leu Pro Leu Gly Ser Gln Leu Arg Val Pro Thr Thr Pro Gly Val Glu
      70                  75                  80

 gct gcg gcc tct gcc tcc tcc cag ctg cgg gca tcg aga gtt cag agc      762
 Ala Ala Ala Ser Ala Ser Ser Gln Leu Arg Ala Ser Arg Val Gln Ser
  85                  90                  95                 100

 ggc acc aga cag tcg gcg cgt gca ggt tta atc cag aag gat gca gct      810
 Gly Thr Arg Gln Ser Ala Arg Ala Gly Leu Ile Gln Lys Asp Ala Ala
                 105                 110                 115

 aaa aag tat gat ttt ccc ata cca ttg aat gaa gct tcc aaa ata atg      858
 Lys Lys Tyr Asp Phe Pro Ile Pro Leu Asn Glu Ala Ser Lys Ile Met
             120                 125                 130

 aag aaa aag aaa aag gtt tta gta tgg aat aga gta tac aaa gtc att      906
 Lys Lys Lys Lys Lys Val Leu Val Trp Asn Arg Val Tyr Lys Val Ile
         135                 140                 145

 tca aga atg ctt gaa gaa aat gaa aaa tat aga cac agg ctg aaa tgc      954
 Ser Arg Met Leu Glu Glu Asn Glu Lys Tyr Arg His Arg Leu Lys Cys
     150                 155                 160

 caa agg tta tct agt gaa agc tca aat tac aca aga tga atcttcttat      1003
 Gln Arg Leu Ser Ser Glu Ser Ser Asn Tyr Thr Arg 
 165                 170                 175

 cttctggaat aacctatctt tgggatgttt cccaaagaag agtatgaaga actctaaaga   1063

 tgaaacatta aatgaatcat aattactttg ttcacctctg catgtgttcc acttagacat   1123

 ggggacttac gttagctcga acagacccaa ttaccg                             1159




      <210> 340
      <211> 702
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (122)..(652)

      <400> 340
 agcggggtct ggacgttggg gagggggctg tgccgggcgg agagaactca gcgaggattc     60

 tgagaatggt agataacgca gatcatctct ggaaaggata ttgatccgcc tcatgtaaag    120

 t    atg ctt agt tcc ttt cca gtg gtt ttg ctg gaa acc atg tct cat     166
      Met Leu Ser Ser Phe Pro Val Val Leu Leu Glu Thr Met Ser His
        1               5                  10                  15

 tat aca gat gaa ccc aga ttt acc ata gag cag ata gat ctg ctt cag      214
 Tyr Thr Asp Glu Pro Arg Phe Thr Ile Glu Gln Ile Asp Leu Leu Gln
                  20                  25                  30

 cga ctt cgg cgt act gga atg act aaa cat gaa att ctc cat gcc ttg      262
 Arg Leu Arg Arg Thr Gly Met Thr Lys His Glu Ile Leu His Ala Leu
              35                  40                  45

 gaa act ttg gac cgt ctt gat caa gag cat agt gac aag ttt gga aga      310
 Glu Thr Leu Asp Arg Leu Asp Gln Glu His Ser Asp Lys Phe Gly Arg
          50                  55                  60

 agg tcc agc tat gga gga agt tca tat ggg aat agt act aac aat gtc      358
 Arg Ser Ser Tyr Gly Gly Ser Ser Tyr Gly Asn Ser Thr Asn Asn Val
      65                  70                  75

 cca gca tct tcc tct aca gct aca gct tcc aca cag acg cag cat tcg      406
 Pro Ala Ser Ser Ser Thr Ala Thr Ala Ser Thr Gln Thr Gln His Ser
  80                  85                  90                  95

 gga atg tcc ccg tca cct agc aac agt tat gat act tcc cca cag cct      454
 Gly Met Ser Pro Ser Pro Ser Asn Ser Tyr Asp Thr Ser Pro Gln Pro
                 100                 105                 110

 tgc act acc aat caa aat ggg agg gag aat aat gag cga tta tct aca      502
 Cys Thr Thr Asn Gln Asn Gly Arg Glu Asn Asn Glu Arg Leu Ser Thr
             115                 120                 125

 tcc aat gga aag atg tca cca act cgc tac cat gca aac agc atg ggt      550
 Ser Asn Gly Lys Met Ser Pro Thr Arg Tyr His Ala Asn Ser Met Gly
         130                 135                 140

 cag agg tca tac agt ttt gaa gcc tca gaa gag gac cta gat gta gat      598
 Gln Arg Ser Tyr Ser Phe Glu Ala Ser Glu Glu Asp Leu Asp Val Asp
     145                 150                 155

 gat aaa gtg gaa gaa tta atg agg tta gtg act ttg ctt att cag agt      646
 Asp Lys Val Glu Glu Leu Met Arg Leu Val Thr Leu Leu Ile Gln Ser
 160                 165                 170                 175

 ccc taa aaatgtctgt attcttagat tgtttttaag tagtatgctg cgtttcagct       702
 Pro 






      <210> 341
      <211> 1006
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (32)..(850)

      <400> 341
 gcttcctttt ttcttttttc cggcgttcaa g   atg tcg aag cga gga cgt ggt      52
                                      Met Ser Lys Arg Gly Arg Gly
                                        1               5

 ggg tcc tct ggt gcg aaa ttc cgg att tcc ttg ggt ctt ccg gta gga      100
 Gly Ser Ser Gly Ala Lys Phe Arg Ile Ser Leu Gly Leu Pro Val Gly
          10                  15                  20

 gct gta atc aat tgt gct gac aac aca gga gcc aaa aac ctg tat atc      148
 Ala Val Ile Asn Cys Ala Asp Asn Thr Gly Ala Lys Asn Leu Tyr Ile
      25                  30                  35

 atc tcc gtg aag ggg atc aag gga cgg ctg aac aga ctt ccc gct gct      196
 Ile Ser Val Lys Gly Ile Lys Gly Arg Leu Asn Arg Leu Pro Ala Ala
  40                  45                  50                  55

 ggt gtg ggt gac atg gtg atg gcc aca gtc aag aaa ggc aaa cca gag      244
 Gly Val Gly Asp Met Val Met Ala Thr Val Lys Lys Gly Lys Pro Glu
                  60                  65                  70

 ctc aga aaa aag gta cat cca gca gtg gtc att cga caa cga aag tca      292
 Leu Arg Lys Lys Val His Pro Ala Val Val Ile Arg Gln Arg Lys Ser
              75                  80                  85

 tac cgt aga aaa gat ggc gtg ttt ctt tat ttt gaa gat aat gca gga      340
 Tyr Arg Arg Lys Asp Gly Val Phe Leu Tyr Phe Glu Asp Asn Ala Gly
          90                  95                 100

 gtc ata gtg aac aat aaa ggc gag atg aaa ggt ttt gcc att aca gga      388
 Val Ile Val Asn Asn Lys Gly Glu Met Lys Gly Phe Ala Ile Thr Gly
     105                 110                 115

 cca gta gca aag gag tgt gca gac ttg tgg ccc cgg att gca tcc aat      436
 Pro Val Ala Lys Glu Cys Ala Asp Leu Trp Pro Arg Ile Ala Ser Asn
 120                 125                 130                 135

 gct ggc agc att gca ttg att ctc cag tat att ggt aca cac ata aac      484
 Ala Gly Ser Ile Ala Leu Ile Leu Gln Tyr Ile Gly Thr His Ile Asn
                 140                 145                 150

 aaa aaa cta aac cct ata aac cca aca aca aca aac aac aca cac acc      532
 Lys Lys Leu Asn Pro Ile Asn Pro Thr Thr Thr Asn Asn Thr His Thr
             155                 160                 165

 acc gtt ggc ggc ccc gaa cat cgg gcc cca gga aag agg ttc tca aaa      580
 Thr Val Gly Gly Pro Glu His Arg Ala Pro Gly Lys Arg Phe Ser Lys
         170                 175                 180

 acc cat ctg gtg agg ccc cgc gga ccc cac acg cta cac cgc aac cgt      628
 Thr His Leu Val Arg Pro Arg Gly Pro His Thr Leu His Arg Asn Arg
     185                 190                 195

 ggg cca caa cca ggt ccc aga gaa gac cgg ggc aca acc aag ggc cgg      676
 Gly Pro Gln Pro Gly Pro Arg Glu Asp Arg Gly Thr Thr Lys Gly Arg
 200                 205                 210                 215

 ggg atc cac acc caa aat aaa aaa acg ccc ggg ggg aca aca gag gcg      724
 Gly Ile His Thr Gln Asn Lys Lys Thr Pro Gly Gly Thr Thr Glu Ala
                 220                 225                 230

 gtc ttg gga caa caa ccc ccc aaa ggc gcc cca gcg agg acc aac ggg      772
 Val Leu Gly Gln Gln Pro Pro Lys Gly Ala Pro Ala Arg Thr Asn Gly
             235                 240                 245

 ccc cac cac agg ggc cca cag cga ccc gaa ata aaa cgg agc agt cgg      820
 Pro His His Arg Gly Pro Gln Arg Pro Glu Ile Lys Arg Ser Ser Arg
         250                 255                 260

 ggg aga caa aac cac cac ata aat aaa taa a caaaacaaat atataagaaa      871
 Gly Arg Gln Asn His His Ile Asn Lys 
     265                 270

 aaaaaaaaca aacttaaaca acaatcaaaa acaataaaca aaacaacaaa aacaaaaaca    931

 acaatacaca acacaaaaca acacatcaga ccccatacac ccatctctat ctactacaac    991

 aaaaacaact acact                                                    1006




      <210> 342
      <211> 806
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (403)..(756)

      <400> 342
 ctttggtcgc tcagcactgc cacgatcaga cacattttgg cgcagcggtg ttggagctgg     60

 tttggcaggc tcaggcaagg gcagagagtg cgacactgaa actttgtctc aggatgacga    120

 aacttacctg gcattttctc cttattcggt ggcaaaaaat gaaaaaatga gttcatggaa    180

 aaatgaaaga gaacacggtt ttacacttgg ggttccagtt caatgaacac ttattaagga    240

 ctttctgaca ttcagaattt tttttctatt atttggctac aaaatattca cgtgagaggc    300

 attaattagg tgcgttgcca tcatttcagg taaagtgaac agagttatct gtgacattcc    360

 atcaggcacc tatgtaacga aatcataccg taataactca cc   atg gcg tat gga     414
                                                  Met Ala Tyr Gly
                                                    1

 gtg cca aga aag aac aca gtg aaa acc att ttg cgg ggc agt tgt tat      462
 Val Pro Arg Lys Asn Thr Val Lys Thr Ile Leu Arg Gly Ser Cys Tyr
   5                  10                  15                  20

 aat gta cag gaa cct tgg gat att gca ttg ctt gca aag acc tgg tac      510
 Asn Val Gln Glu Pro Trp Asp Ile Ala Leu Leu Ala Lys Thr Trp Tyr
                  25                  30                  35

 aca aac cta gcc aat atc aag ttg cct ttc ttg gaa gaa att tca ttt      558
 Thr Asn Leu Ala Asn Ile Lys Leu Pro Phe Leu Glu Glu Ile Ser Phe
              40                  45                  50

 ggt ggt tct gtg cag ctc aca aaa tgt acc acc att aaa gat gga ctg      606
 Gly Gly Ser Val Gln Leu Thr Lys Cys Thr Thr Ile Lys Asp Gly Leu
          55                  60                  65

 ctc cct tct gca gaa tct atc aaa ctc gaa agg gag tat gaa gtg aag      654
 Leu Pro Ser Ala Glu Ser Ile Lys Leu Glu Arg Glu Tyr Glu Val Lys
      70                  75                  80

 cgt ctt tgt aaa ctg aag tgt caa gaa aat aca tct aag gaa att cag      702
 Arg Leu Cys Lys Leu Lys Cys Gln Glu Asn Thr Ser Lys Glu Ile Gln
  85                  90                  95                 100

 ctt ctc ctg agg gaa agg cca gcc ggt ttg aga aga cct ctt cca tct      750
 Leu Leu Leu Arg Glu Arg Pro Ala Gly Leu Arg Arg Pro Leu Pro Ser
                 105                 110                 115

 aaa tga cagtcagttc atgattgaat ctgtactctg tgtcttgcat ccaaagggca       806
 Lys 






      <210> 343
      <211> 1815
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1815)

      <400> 343
  atg ttg gat acg atc gcc cgt gcc ctg cag gac ctg ggc agg cag gtg      48
  Met Leu Asp Thr Ile Ala Arg Ala Leu Gln Asp Leu Gly Arg Gln Val
    1               5                  10                  15

 ctg ccc act ctg ccc tcg ctg agc cag gag gaa gtc tct att atc tgg       96
 Leu Pro Thr Leu Pro Ser Leu Ser Gln Glu Glu Val Ser Ile Ile Trp
              20                  25                  30

 ggg aat gta tca gaa ttt gtg aga cgg cag tta acc ctg cac aag ggg      144
 Gly Asn Val Ser Glu Phe Val Arg Arg Gln Leu Thr Leu His Lys Gly
          35                  40                  45

 gtt cag att cca gca ttt gga act ttc act ttc ata aga caa aag ctt      192
 Val Gln Ile Pro Ala Phe Gly Thr Phe Thr Phe Ile Arg Gln Lys Leu
      50                  55                  60

 gag gtg gga aac aac aaa ttt atc tta atc cag agg cct gtg ttt atc      240
 Glu Val Gly Asn Asn Lys Phe Ile Leu Ile Gln Arg Pro Val Phe Ile
  65                  70                  75                  80

 atg gtg gag aag cta gtg cag atc cat gga ctc aaa caa aac aaa gta      288
 Met Val Glu Lys Leu Val Gln Ile His Gly Leu Lys Gln Asn Lys Val
                  85                  90                  95

 tat act cct ggt gaa atc cca att gtt cca ctt aat ttt gtc atg ata      336
 Tyr Thr Pro Gly Glu Ile Pro Ile Val Pro Leu Asn Phe Val Met Ile
             100                 105                 110

 tcc ctg gag ggt cca ttt aac aga gat gta gtg gaa gga tgt gtg aag      384
 Ser Leu Glu Gly Pro Phe Asn Arg Asp Val Val Glu Gly Cys Val Lys
         115                 120                 125

 gag acg ttg ctt ttt tta tcg cgt tcc att tcc atg aaa caa aat gtg      432
 Glu Thr Leu Leu Phe Leu Ser Arg Ser Ile Ser Met Lys Gln Asn Val
     130                 135                 140

 gag ttt aca ttc aaa gga att ggg gtc ctc atg atc aga gac agc aaa      480
 Glu Phe Thr Phe Lys Gly Ile Gly Val Leu Met Ile Arg Asp Ser Lys
 145                 150                 155                 160

 gtg aag atg agg ttt tat aaa gac ttc ctt tgt acc atg gat gga agt      528
 Val Lys Met Arg Phe Tyr Lys Asp Phe Leu Cys Thr Met Asp Gly Ser
                 165                 170                 175

 ggg gct ttg gca aag gcc cta gca aat agg cct ggc act gtg gac tcg      576
 Gly Ala Leu Ala Lys Ala Leu Ala Asn Arg Pro Gly Thr Val Asp Ser
             180                 185                 190

 gtg ttg tct agc aga gag gcc ttg agg aag tgg ccc agc agt gtg ctt      624
 Val Leu Ser Ser Arg Glu Ala Leu Arg Lys Trp Pro Ser Ser Val Leu
         195                 200                 205

 gcg ttt cca agg att gag ctc aag gag atg gaa aac aaa ctg cct atg      672
 Ala Phe Pro Arg Ile Glu Leu Lys Glu Met Glu Asn Lys Leu Pro Met
     210                 215                 220

 gag acc ctt gta gaa gaa tgt gga gag aat aga gaa agg aag tgc aag      720
 Glu Thr Leu Val Glu Glu Cys Gly Glu Asn Arg Glu Arg Lys Cys Lys
 225                 230                 235                 240

 tta aaa gac cag tca gac aaa gaa gaa ggc acc aga gat atc tca tca      768
 Leu Lys Asp Gln Ser Asp Lys Glu Glu Gly Thr Arg Asp Ile Ser Ser
                 245                 250                 255

 ccc aaa aga ctt cga gat aga caa gct ttg ttc cct gcc aaa gtg aca      816
 Pro Lys Arg Leu Arg Asp Arg Gln Ala Leu Phe Pro Ala Lys Val Thr
             260                 265                 270

 aat gtc agc ttg ctg gaa aag ttt gaa cga agt gag agt ggt ggg aag      864
 Asn Val Ser Leu Leu Glu Lys Phe Glu Arg Ser Glu Ser Gly Gly Lys
         275                 280                 285

 att atg acc cct gaa agt gag gaa agg agg aga gag ata gaa gat gag      912
 Ile Met Thr Pro Glu Ser Glu Glu Arg Arg Arg Glu Ile Glu Asp Glu
     290                 295                 300

 aga ctc ata cag cag tat cag atg tta aag gat cag gag gct ctc ttc      960
 Arg Leu Ile Gln Gln Tyr Gln Met Leu Lys Asp Gln Glu Ala Leu Phe
 305                 310                 315                 320

 aga cac cag atg aaa agt ctg gct act aga gaa cag aat cag aaa aat     1008
 Arg His Gln Met Lys Ser Leu Ala Thr Arg Glu Gln Asn Gln Lys Asn
                 325                 330                 335

 gct gcc tat aat ctt gga gtt gct gaa gct ata aga aac cac aag aat     1056
 Ala Ala Tyr Asn Leu Gly Val Ala Glu Ala Ile Arg Asn His Lys Asn
             340                 345                 350

 gag aaa ccg gaa ttt tat aaa tcc ttc cta ttt gac aaa cgg cca ctc     1104
 Glu Lys Pro Glu Phe Tyr Lys Ser Phe Leu Phe Asp Lys Arg Pro Leu
         355                 360                 365

 agt cct gcg ctt aat gct ctt aag caa gag gaa tat tcc cgg agt ctc     1152
 Ser Pro Ala Leu Asn Ala Leu Lys Gln Glu Glu Tyr Ser Arg Ser Leu
     370                 375                 380

 ctg aaa caa atg gat aac aga cag gaa aac gaa ata aag caa aga caa     1200
 Leu Lys Gln Met Asp Asn Arg Gln Glu Asn Glu Ile Lys Gln Arg Gln
 385                 390                 395                 400

 tac aga gag ttg atg gac cgc ctg gaa caa gtg caa ctc aca gag gaa     1248
 Tyr Arg Glu Leu Met Asp Arg Leu Glu Gln Val Gln Leu Thr Glu Glu
                 405                 410                 415

 ctt gct gcg caa aga gcg aaa ttt tta aaa gat aag atg gaa gaa aca     1296
 Leu Ala Ala Gln Arg Ala Lys Phe Leu Lys Asp Lys Met Glu Glu Thr
             420                 425                 430

 cag tgt tac aag aga gct ttg gat gca cag ata aag aac aaa ccc tct     1344
 Gln Cys Tyr Lys Arg Ala Leu Asp Ala Gln Ile Lys Asn Lys Pro Ser
         435                 440                 445

 cgg ctg ccc ccc ttt gag cca gac tcc tct gag ccc atc ttt ggt aag     1392
 Arg Leu Pro Pro Phe Glu Pro Asp Ser Ser Glu Pro Ile Phe Gly Lys
     450                 455                 460

 aat gag ggt gaa ctg atg gtg gaa aag caa aag cga gaa caa aat tac     1440
 Asn Glu Gly Glu Leu Met Val Glu Lys Gln Lys Arg Glu Gln Asn Tyr
 465                 470                 475                 480

 atg aaa cac cag ctg gag gca gct gct aac cac aag agg aaa gcc atc     1488
 Met Lys His Gln Leu Glu Ala Ala Ala Asn His Lys Arg Lys Ala Ile
                 485                 490                 495

 ctg cat caa cta gtg gac cag agg cgg gat ttg caa atg ctt cag agg     1536
 Leu His Gln Leu Val Asp Gln Arg Arg Asp Leu Gln Met Leu Gln Arg
             500                 505                 510

 aca caa aga gag cac ttg gca gac aga acc gct gag ctg gag cga gta     1584
 Thr Gln Arg Glu His Leu Ala Asp Arg Thr Ala Glu Leu Glu Arg Val
         515                 520                 525

 aat aga gtc aac caa tgc tta cag gag gac tgg gaa agg agt gct gcg     1632
 Asn Arg Val Asn Gln Cys Leu Gln Glu Asp Trp Glu Arg Ser Ala Ala
     530                 535                 540

 atg aag aag cag cga gac ctg gag gac aag gct ttt gaa cgg gct tca     1680
 Met Lys Lys Gln Arg Asp Leu Glu Asp Lys Ala Phe Glu Arg Ala Ser
 545                 550                 555                 560

 gac aag ctg ttt ctc cta gac cag tgt gag aag tat cgg cgc tgc aag     1728
 Asp Lys Leu Phe Leu Leu Asp Gln Cys Glu Lys Tyr Arg Arg Cys Lys
                 565                 570                 575

 caa tgc cag agg cgc acc tcc aat gtg ggc gag agc aac ctg tgg ccc     1776
 Gln Cys Gln Arg Arg Thr Ser Asn Val Gly Glu Ser Asn Leu Trp Pro
             580                 585                 590

 ctg aac aag ttc ctg cct ggc tcc cgg ttg ctt gtg taa                 1815
 Leu Asn Lys Phe Leu Pro Gly Ser Arg Leu Leu Val 
         595                 600





      <210> 344
      <211> 300
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(300)

      <400> 344
  atg tgg ccc caa ccc cgc ctc cct ccc cgc ccc gcg atg tcg gaa gaa      48
  Met Trp Pro Gln Pro Arg Leu Pro Pro Arg Pro Ala Met Ser Glu Glu
    1               5                  10                  15

 acc cga cag agc aaa ttg gcc gca gcg aag aaa aag ttg aga gaa tat       96
 Thr Arg Gln Ser Lys Leu Ala Ala Ala Lys Lys Lys Leu Arg Glu Tyr
              20                  25                  30

 cag cag agg aat agc cct ggt gtt cct aca gga gcg aaa aag aag aag      144
 Gln Gln Arg Asn Ser Pro Gly Val Pro Thr Gly Ala Lys Lys Lys Lys
          35                  40                  45

 aaa ata aaa aat ggc agt aac cct gag aca acc act tct ggt ggt tgc      192
 Lys Ile Lys Asn Gly Ser Asn Pro Glu Thr Thr Thr Ser Gly Gly Cys
      50                  55                  60

 cac tca cct gag gat gtg agt ctt gga tgg cca ggc tcc tgg gga cag      240
 His Ser Pro Glu Asp Val Ser Leu Gly Trp Pro Gly Ser Trp Gly Gln
  65                  70                  75                  80

 ggg gcc caa ggg gca gta gag ggt aat tgt tat gat tgt gga aga act      288
 Gly Ala Gln Gly Ala Val Glu Gly Asn Cys Tyr Asp Cys Gly Arg Thr
                  85                  90                  95

 gtt ggg tac tga                                                      300
 Val Gly Tyr 






      <210> 345
      <211> 418
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (46)..(384)

      <400> 345
 atttaagtca atactataaa aagaaacaaa gaagtttgtt atata    atg ata aag      54
                                                      Met Ile Lys
                                                        1

 gga tta att cac caa gaa gac ata aca att gta aaa gta tat gca ccc      102
 Gly Leu Ile His Gln Glu Asp Ile Thr Ile Val Lys Val Tyr Ala Pro
       5                  10                  15

 aac att gac cca cct aaa tac ata aag caa ttt tta aat gat gtg aag      150
 Asn Ile Asp Pro Pro Lys Tyr Ile Lys Gln Phe Leu Asn Asp Val Lys
  20                  25                  30                  35

 agg gag ata ggc tgc aat act ata ata cgg gac ctc aat act cta ctt      198
 Arg Glu Ile Gly Cys Asn Thr Ile Ile Arg Asp Leu Asn Thr Leu Leu
                  40                  45                  50

 ttc acc atg ggc aga ttg ata cct aga cag aaa agc aat aaa gaa aca      246
 Phe Thr Met Gly Arg Leu Ile Pro Arg Gln Lys Ser Asn Lys Glu Thr
              55                  60                  65

 atg gat ttc aat tac act tta gac caa acg gac tta aca ggc ata tat      294
 Met Asp Phe Asn Tyr Thr Leu Asp Gln Thr Asp Leu Thr Gly Ile Tyr
          70                  75                  80

 gaa aca ttc cat cca gaa gca gca aaa tac att ttg ttc tca aat gcc      342
 Glu Thr Phe His Pro Glu Ala Ala Lys Tyr Ile Leu Phe Ser Asn Ala
      85                  90                  95

 cat gga aca ttc tcc agg ata tat gtt agt cca caa aac taa tcttaag      391
 His Gly Thr Phe Ser Arg Ile Tyr Val Ser Pro Gln Asn 
 100                 105                 110

 tttaagtgga cagaaatcat atcaaat                                        418




      <210> 346
      <211> 593
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (100)..(480)

      <400> 346
 aagtgcatgg cctccctggg cgtccacccg cactgcaggg ctgagctgag caaatgttag     60

 tgggtggcca gagctgcacg tgcacacaca cactcaagc   atg ggt tcc ccc cca     114
                                              Met Gly Ser Pro Pro
                                                1               5

 caa gtt cac aca cac act cac gtg tgg att cac ctg cac tca cat gcg      162
 Gln Val His Thr His Thr His Val Trp Ile His Leu His Ser His Ala
                  10                  15                  20

 tgg gtt cac ccg cac gca ttc aca cac aca tgt gtg ggt tca cct aca      210
 Trp Val His Pro His Ala Phe Thr His Thr Cys Val Gly Ser Pro Thr
              25                  30                  35

 ctc aca ctc atg ctt ggg ttc acc cac acg cac tca cac aca cac gcg      258
 Leu Thr Leu Met Leu Gly Phe Thr His Thr His Ser His Thr His Ala
          40                  45                  50

 tgg gtt cac ccg cac tca cac act ccc aca cgt ggg ttc act cgt atg      306
 Trp Val His Pro His Ser His Thr Pro Thr Arg Gly Phe Thr Arg Met
      55                  60                  65

 tat tca cac gca cac tca cgt gtg ggt tca cct gca cac act cac atg      354
 Tyr Ser His Ala His Ser Arg Val Gly Ser Pro Ala His Thr His Met
  70                  75                  80                  85

 cac act cac acg tgg gtt cac cca cac gcg cac aca cac aga gca cac      402
 His Thr His Thr Trp Val His Pro His Ala His Thr His Arg Ala His
                  90                  95                 100

 tct ggc gca tgc atg gac aca gtc agg ccc gtg ctc tct gag gtc cga      450
 Ser Gly Ala Cys Met Asp Thr Val Arg Pro Val Leu Ser Glu Val Arg
             105                 110                 115

 tgg agg gca tcg ttc tgg gag ctt ccc tga c ccctgggtgt cccgcgcctg      501
 Trp Arg Ala Ser Phe Trp Glu Leu Pro 
         120                 125

 ccctcttcag tggtggtgga ggccgggcag gccgcggtac cagtgggagg agaggctggc    561

 tatggagttg gtgcctggca ttctttcata aa                                  593




      <210> 347
      <211> 1365
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (916)..(1356)

      <400> 347
 cagcgggcgg aggggggggc gcgcgggaag ggggagcggg gtgaggacgg gggaggcggt     60

 ggtggtgcag ggcgcggggc agggcccccg ggatgccgaa ggaagggacc catagagcgt    120

 gtgcgcaagc cgaaagaggc gcgaaggggc caggagggcc gagaggagcc tcgtggagcg    180

 aacccagccg tgctggcctg gctggccctg gtcaacaggc tcggaagagg ccgatttgga    240

 ggacagaacg gaagaaaaga cctaaaggtt tcgaatctca tgacgcagag atgttaagaa    300

 tcgtccaatc ctaaggtccg actgtgcggg ggagtcgagg gggtctcaag ctggattgac    360

 cccgagcctt catcgtggag agtcctctgc acaagctcag agcaggacaa cgcgcatcag    420

 tggttctcaa gagggggcaa cttcgccctt acacgcctct cccatccccg ctgggacact    480

 aggtcacgaa tgggggaagc ggggagggag aatgctaacc ccctggcatg tatctagtca    540

 gcggaggcga cggctgctgc taaacacctt acaatccacg ggagggcccc tcccgtaccc    600

 cgaagtagcc attccgcaga ggtggagaga ctcgcgtgta gctcaatgcc cacgcactta    660

 gccgatggga aatcacgaac ttgatgacca gttggctctt ggatctgagg aaaaatctcc    720

 agcgatcaga tgggaactca tcgaagtttt gcccggagca atacggaagg gtggcgttgc    780

 catcgcctaa aatgggaaaa aggcaggcgt cacaggttgc aggggaaggt tggagaccag    840

 ttgagtgccc cggagccttc ctggaaagag tttcctatcc agcccgtctc ggtttccgca    900

 tccgtctgat tcctt atg atg ttg agg gtg ccg ggg tct ggg tcc ttt atg     951
                  Met Met Leu Arg Val Pro Gly Ser Gly Ser Phe Met
                    1               5                  10

 atg cag agg gtg ccc ctg tct cac ctc ggg cgc ctc ccc gct ccc gcc      999
 Met Gln Arg Val Pro Leu Ser His Leu Gly Arg Leu Pro Ala Pro Ala
          15                  20                  25

 tcc tcc tgg caa cct ggt ggg cgg ctc cgg acc cgg cga ccc gcg acc     1047
 Ser Ser Trp Gln Pro Gly Gly Arg Leu Arg Thr Arg Arg Pro Ala Thr
      30                  35                  40

 atc ttg tca gtt gct gcc gcc tgg caa agg gca tct cta ggc cag ttg     1095
 Ile Leu Ser Val Ala Ala Ala Trp Gln Arg Ala Ser Leu Gly Gln Leu
  45                  50                  55                  60

 gtg agc tgc ggc cgc gtg gcc gca act cgc tcc agt act cag gac tcc     1143
 Val Ser Cys Gly Arg Val Ala Ala Thr Arg Ser Ser Thr Gln Asp Ser
                  65                  70                  75

 ctc gtg gag ccc ttg gtg tgt cgc ctg cag gtt ctt ttt ttg aag aaa     1191
 Leu Val Glu Pro Leu Val Cys Arg Leu Gln Val Leu Phe Leu Lys Lys
              80                  85                  90

 gca ggg agt gaa cgg cct tgt gag acg act cca gga gca aag gga gac     1239
 Ala Gly Ser Glu Arg Pro Cys Glu Thr Thr Pro Gly Ala Lys Gly Asp
          95                 100                 105

 tct cac aag acc caa gtc ctc cta gag cac agg aaa gtg tcg ctt cag     1287
 Ser His Lys Thr Gln Val Leu Leu Glu His Arg Lys Val Ser Leu Gln
     110                 115                 120

 gtc gaa gaa ggg aga gaa agc agc ttt ccg cat ctg cat ggt tgt cta     1335
 Val Glu Glu Gly Arg Glu Ser Ser Phe Pro His Leu His Gly Cys Leu
 125                 130                 135                 140

 gtg gct agg att cgg tgc tga aagcgccac                               1365
 Val Ala Arg Ile Arg Cys 
                 145





      <210> 348
      <211> 804
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(804)

      <400> 348
  atg tgt ata cat gaa ggt ttg caa agc aga caa att acg ctt cac ttc      48
  Met Cys Ile His Glu Gly Leu Gln Ser Arg Gln Ile Thr Leu His Phe
    1               5                  10                  15

 aac gat cac agt aaa acc agt aaa ata aga acc aaa aaa aat aaa gac       96
 Asn Asp His Ser Lys Thr Ser Lys Ile Arg Thr Lys Lys Asn Lys Asp
              20                  25                  30

 cca act caa tgg att gct act ttt ggt gca act ata aca cca ccc gca      144
 Pro Thr Gln Trp Ile Ala Thr Phe Gly Ala Thr Ile Thr Pro Pro Ala
          35                  40                  45

 gtg aaa cga aat gtg agg aaa att att ctt cat gag aat tac cat aga      192
 Val Lys Arg Asn Val Arg Lys Ile Ile Leu His Glu Asn Tyr His Arg
      50                  55                  60

 gaa aca aat gaa aat gac att gct ttg gtt cag ctc tct act gga gtt      240
 Glu Thr Asn Glu Asn Asp Ile Ala Leu Val Gln Leu Ser Thr Gly Val
  65                  70                  75                  80

 gag ttt tca aat ata gtc cag aga gtt tgc ctc cca gac tca tct ata      288
 Glu Phe Ser Asn Ile Val Gln Arg Val Cys Leu Pro Asp Ser Ser Ile
                  85                  90                  95

 aag ttg cca cct aaa aca agt gtg ttc gtc aca gga ttt gga tcc att      336
 Lys Leu Pro Pro Lys Thr Ser Val Phe Val Thr Gly Phe Gly Ser Ile
             100                 105                 110

 gta gat gat gga cct ata caa aat aca ctt cgg caa gcc aga gtg gaa      384
 Val Asp Asp Gly Pro Ile Gln Asn Thr Leu Arg Gln Ala Arg Val Glu
         115                 120                 125

 acc ata agc act gat gtg tgt aac aga aag gat gtg tat gat ggc ctg      432
 Thr Ile Ser Thr Asp Val Cys Asn Arg Lys Asp Val Tyr Asp Gly Leu
     130                 135                 140

 ata act cca gga atg tta tgt gct gga ttc atg gaa gga aaa ata gat      480
 Ile Thr Pro Gly Met Leu Cys Ala Gly Phe Met Glu Gly Lys Ile Asp
 145                 150                 155                 160

 gca tgt aag gga gat tct ggt gga cct ctg gtt tat gat aat cat gac      528
 Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Tyr Asp Asn His Asp
                 165                 170                 175

 atc tgg tac att gta ggt ata gta agt tgg gga caa tca tgt gca ctt      576
 Ile Trp Tyr Ile Val Gly Ile Val Ser Trp Gly Gln Ser Cys Ala Leu
             180                 185                 190

 ccc aaa aaa cct gga gtc tac acc aga gta act aag tat cga gat tgg      624
 Pro Lys Lys Pro Gly Val Tyr Thr Arg Val Thr Lys Tyr Arg Asp Trp
         195                 200                 205

 att gcc tca aag act ggc agc tcc tcc tta aga aca gac aca aat gaa      672
 Ile Ala Ser Lys Thr Gly Ser Ser Ser Leu Arg Thr Asp Thr Asn Glu
     210                 215                 220

 ttg cca ggc cag ata tca tca gca caa gta tca ttg cct gaa gaa aag      720
 Leu Pro Gly Gln Ile Ser Ser Ala Gln Val Ser Leu Pro Glu Glu Lys
 225                 230                 235                 240

 caa atc aag ggc cat aga atg ttt tat gaa aac ctc tgg tgt gtt aaa      768
 Gln Ile Lys Gly His Arg Met Phe Tyr Glu Asn Leu Trp Cys Val Lys
                 245                 250                 255

 agc ttg cct ctg aaa gag atg aat atc agg gcc tga                      804
 Ser Leu Pro Leu Lys Glu Met Asn Ile Arg Ala 
             260                 265





      <210> 349
      <211> 1196
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (270)..(1196)

      <400> 349
 gccaaaatgg cggacacaat gagccggcga cgcgccggtt gtccgtgagg tggctgtgag     60

 gacgaacggt cggcgaggct ccacagtcca ggcagaagac cctcgaccaa gcaggaagaa    120

 gaggaggagg cggcccaact gttggccgac ttcccgctag ccgccggcgc ggcgcccgcc    180

 ccgcctgggt tggcccctcg gcagcccgcc cgctcgccgc cgggccccgc cccggccctg    240

 cgccgccgct gccttcccca gccgccgcc  atg aag ctg acc gac agc gtg ttg     293
                                  Met Lys Leu Thr Asp Ser Val Leu
                                    1               5

 cgg agc ttc cgc gtc gct aag gtg ttc cgc gaa aac tcg gac aag att      341
 Arg Ser Phe Arg Val Ala Lys Val Phe Arg Glu Asn Ser Asp Lys Ile
      10                  15                  20

 aac tgc ttc gat ttc agc ccc aac ggc gag acg gtc atc tcg agt agc      389
 Asn Cys Phe Asp Phe Ser Pro Asn Gly Glu Thr Val Ile Ser Ser Ser
  25                  30                  35                  40

 gac gac gac tcc atc gtg ctc tat gac tgc cag gag ggc aaa cca aag      437
 Asp Asp Asp Ser Ile Val Leu Tyr Asp Cys Gln Glu Gly Lys Pro Lys
                  45                  50                  55

 aga acc ctg tac agt aag aaa tat ggt gtg gac ctc atc aga tac act      485
 Arg Thr Leu Tyr Ser Lys Lys Tyr Gly Val Asp Leu Ile Arg Tyr Thr
              60                  65                  70

 cat gca gca aac aca gtt gtt tac agc tct aac aaa ata gac gat act      533
 His Ala Ala Asn Thr Val Val Tyr Ser Ser Asn Lys Ile Asp Asp Thr
          75                  80                  85

 att cgt tac ttg tcc ttg cat gac aac aaa tac atc aga tac ttt cct      581
 Ile Arg Tyr Leu Ser Leu His Asp Asn Lys Tyr Ile Arg Tyr Phe Pro
      90                  95                 100

 gga cat agc aaa agg gtg gtg gcc ttg tcc atg tca cct gtg gat gac      629
 Gly His Ser Lys Arg Val Val Ala Leu Ser Met Ser Pro Val Asp Asp
 105                 110                 115                 120

 act ttc att tct ggg tct ctt gat aag acc att cga ctc tgg gat ctc      677
 Thr Phe Ile Ser Gly Ser Leu Asp Lys Thr Ile Arg Leu Trp Asp Leu
                 125                 130                 135

 cgg tct cct aac tgc cag ggc ctc atg cat ctg cag ggg aag cca gtt      725
 Arg Ser Pro Asn Cys Gln Gly Leu Met His Leu Gln Gly Lys Pro Val
             140                 145                 150

 tgt tct ttt gat cca gaa ggg tta att ttc gct gca ggt gtc aac tct      773
 Cys Ser Phe Asp Pro Glu Gly Leu Ile Phe Ala Ala Gly Val Asn Ser
         155                 160                 165

 gaa atg gtc aag ctt tat gac ctt cgt tct ttt gat aag ggg cca ttt      821
 Glu Met Val Lys Leu Tyr Asp Leu Arg Ser Phe Asp Lys Gly Pro Phe
     170                 175                 180

 gct acc ttt aag atg cag tat gat cga act tgt gag tgg aca gga ctt      869
 Ala Thr Phe Lys Met Gln Tyr Asp Arg Thr Cys Glu Trp Thr Gly Leu
 185                 190                 195                 200

 aag ttc agc aat gat ggc aag ctc atc ctc att tcc acc aac ggc agc      917
 Lys Phe Ser Asn Asp Gly Lys Leu Ile Leu Ile Ser Thr Asn Gly Ser
                 205                 210                 215

 ttc att cgt ctg att gat gca ttc aaa gga gtg gtg atg cac aca ttt      965
 Phe Ile Arg Leu Ile Asp Ala Phe Lys Gly Val Val Met His Thr Phe
             220                 225                 230

 ggg ggt tat gcc aac agc aaa gct gtc aca ctg gag gct tca ttt act     1013
 Gly Gly Tyr Ala Asn Ser Lys Ala Val Thr Leu Glu Ala Ser Phe Thr
         235                 240                 245

 cca gac tct cag ttt att atg att ggt tca gag gat ggc aag atc cat     1061
 Pro Asp Ser Gln Phe Ile Met Ile Gly Ser Glu Asp Gly Lys Ile His
     250                 255                 260

 gtc tgg aat gga gag agc ggt ata aaa gta gct gtg ttg gat ggt aaa     1109
 Val Trp Asn Gly Glu Ser Gly Ile Lys Val Ala Val Leu Asp Gly Lys
 265                 270                 275                 280

 cac aca ggc ccg att acc tgt ttg caa ttc aac ccc aag ttc atg act     1157
 His Thr Gly Pro Ile Thr Cys Leu Gln Phe Asn Pro Lys Phe Met Thr
                 285                 290                 295

 ttt gcc agt gcg tgt tcc aac atg gta tgt gaa cag taa                 1196
 Phe Ala Ser Ala Cys Ser Asn Met Val Cys Glu Gln 
             300                 305





      <210> 350
      <211> 1120
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (192)..(842)

      <220>
      <221> misc_feature
      <222> (1)...(1120)
      <223> n = a,t,c or g

      <400> 350
 acggcggcga gcaggctgca ggccgcgggg atncggggcg cggggggcgc cgggcctgat     60

 cgccgcctct cgcggtgccc gcaggncccc gggcgcgcag ctctcgcccc gccgccgcct    120

 gccccgggcc ccggagcgcg gtggagaagc ccccggagga gcggggggcc cgcgccccgc    180

 gccccccaga c atg gtg ggc cac ctg cat ctg cag ggc atg gag gac agc     230
              Met Val Gly His Leu His Leu Gln Gly Met Glu Asp Ser
                1               5                  10

 ctg aag gag cag ggc cgg gag ggc ttg ctg gac agc ccc gac tcc ggg      278
 Leu Lys Glu Gln Gly Arg Glu Gly Leu Leu Asp Ser Pro Asp Ser Gly
      15                  20                  25

 ctg ccc ccc agc ccc agc ccc agc ccg ccc ttc tac tcc ctg gcg ccc      326
 Leu Pro Pro Ser Pro Ser Pro Ser Pro Pro Phe Tyr Ser Leu Ala Pro
  30                  35                  40                  45

 ggc atc ctc gac gcg cgc gcg ggg ggc gcc ggc gcc tcc tcg gag ccc      374
 Gly Ile Leu Asp Ala Arg Ala Gly Gly Ala Gly Ala Ser Ser Glu Pro
                  50                  55                  60

 ccg gga ccc agc gag gcc aga aga gcc ccc tcc caa ctc cca aat ccc      422
 Pro Gly Pro Ser Glu Ala Arg Arg Ala Pro Ser Gln Leu Pro Asn Pro
              65                  70                  75

 ccg gcg tcg gag atg agg ccc cgg atg ctg cca gtg ttc ttt ggg gag      470
 Pro Ala Ser Glu Met Arg Pro Arg Met Leu Pro Val Phe Phe Gly Glu
          80                  85                  90

 agc atc aag gtg aac ccg gaa ccc acg cat gag atc cgc tgc aac tct      518
 Ser Ile Lys Val Asn Pro Glu Pro Thr His Glu Ile Arg Cys Asn Ser
      95                 100                 105

 gag gtc aag tac gcc tcg gag aag cat ttc cag gac aag gtc ttc tat      566
 Glu Val Lys Tyr Ala Ser Glu Lys His Phe Gln Asp Lys Val Phe Tyr
 110                 115                 120                 125

 gcg ccc gta ccc acc gtc acg gcc tac agc gag acc atc gtg gca gca      614
 Ala Pro Val Pro Thr Val Thr Ala Tyr Ser Glu Thr Ile Val Ala Ala
                 130                 135                 140

 ccc aac tgc acg tgg cgc aac tac cgc agc cag ctg acc ctg gag cca      662
 Pro Asn Cys Thr Trp Arg Asn Tyr Arg Ser Gln Leu Thr Leu Glu Pro
             145                 150                 155

 cgc ccg cgc gcc ctg cgc ttc cgc agc acc acc atc atc ttc ccc aag      710
 Arg Pro Arg Ala Leu Arg Phe Arg Ser Thr Thr Ile Ile Phe Pro Lys
         160                 165                 170

 cat gcc agg agc act ttc cgg acc acc ctg cac tgc agc ctg ggc cgg      758
 His Ala Arg Ser Thr Phe Arg Thr Thr Leu His Cys Ser Leu Gly Arg
     175                 180                 185

 ccc agc cgc tgg ttc acc gcc agc gtg cag ctg cag ctt tgc cag gac      806
 Pro Ser Arg Trp Phe Thr Ala Ser Val Gln Leu Gln Leu Cys Gln Asp
 190                 195                 200                 205

 cct gcc ccc agc ctc ctg ggc cct gcc acg ctc tga cggg gctggggccg      856
 Pro Ala Pro Ser Leu Leu Gly Pro Ala Thr Leu 
                 210                 215

 gcccggggtg ctggaggagc cgggagccct ggggagaagc cgggaggatg gacacgatga    916

 gctcggcctg gcactcgggc aggaggcggg aagggaggct gtccagacca aggacccgtg    976

 tggaaggagg cggctccccg ctgcctgccc tgtacctaca ggctaggtgg tggtctcctt   1036

 gtttcggtgt caaggactca gtaaaagcat ctattttttt agcacttaag ctggcaaggc   1096

 ggtaggggca tgcactgtaa ggtg                                          1120




      <210> 351
      <211> 4338
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1906)..(4338)

      <400> 351
 ttacagtttt cgaaacaagc ccccaaaata taaaatcaca tttacagttt ctagatcttc     60

 atatttctgc aagcaacatt cacaatatcc ttttttcttc ttctctttca actggagttg    120

 aattgaggtt ccaccatact tatcgccatc tgtttggatt cttagtttaa cctgagtttg    180

 cttttgcata ctagatggct tgtctacatc aaatggactg cagggcttct gaatagaata    240

 atttataaaa ggcatattgg tcagctgaag ataaaatggc ctataaagtt ggctcatatc    300

 ttccaccttt acaaaaggct ttttgagtct tcttcttgtt ttttgtgcac cactaccaac    360

 tcttttgcca tggtccttga tagctttttc aactaataat tttcctctgc ttaaacacac    420

 tgtgtctggt gacttaaatg aacttccatc atggctggga tgaggtgaag tggtttctgc    480

 agtatatgca gattctggac ttggtacagg agaaattcga cccaaggttt gtgcaaattt    540

 agcttccttc ttatttgaaa taagataact gatatctttg ctgagaaatt cttcaactcg    600

 ccctcccaga tccttaatgt ccttttgaag tttttcagat atggtgacag aaggtaagtc    660

 aaggtaaaat acttttcccc aaagtggctt acatttggat ttttctggcc tgttatcagt    720

 tttcagagat ttcagagatg gtctgttttt ttcatttttg acttggattc cacaatcact    780

 caatctaatc ctgaagcgaa aagccacgag cgcgtctgac tttaaattga ggatgcagtc    840

 cgtcgcctcc aagggcccgg gcggaggctt agcatatgcg agagcccggg agcagacagc    900

 gccgcagtcc cggcgaggtc ccggatctgc acattgtttg ctagttttca accgaaggca    960

 cgaccgggaa tcaatctggg accgccgatg ctgggtccgg agaaagtgtc gcaccgggca   1020

 gccgcgaaag cacggcttcc cccggcctgt tgacaggacg gccgcctctc tccttccgcc   1080

 agctacggcc tctacgcagt agaggtaccg cgtctgcagg tcgggtttcc ggggccggat   1140

 ccggctccaa ggcgcggagg aggaaggcgc aaagcacaaa cgagtgggct gcggcggttg   1200

 aagatttgaa aacgcgtcac gcggccgcgc gccgatacgc gcgccccgcc ccgtctcacg   1260

 ccacgcgccg tgccccgcct cgcgctcgcc cctcgtgcct gccttctcgc gctgcgcgcc   1320

 ccgccccctc acgccgccgt ccttctcgcg cctcgctctg gccctgcagg ttgtgtttcc   1380

 gcctctaccc cgcctccatt ccgttgctct ctcagtctca gacccgggct ctcggtccgc   1440

 cgcttcaggt cttggcgcag cctcagagag ttggcgcggc tctgtgttga ccaaaccagg   1500

 gttattcccg ccttctaggt ttgccaggac tgccggccct gcagctgcct tctgccccag   1560

 gtatgctaat tttccactgg tcggacgtct gggaagctga aggcgagggg ctttggctga   1620

 gtccggactc agctctggcc gggccggggg cccggggccg gaaccggagc cggacagcgg   1680

 cggcagccgc agcccctgct cagcgcgccc tgggtcgcac agcaagcggg gttttcccgc   1740

 ggtcactgcc gaccccaccg gctgaggaca gctgagttct tgtcgggcat ccaggaggaa   1800

 tgaggtcaca cgaacaactt caatatggta aatgcaggga gttttattgc tgatgaaagt   1860

 ggctctcagc aagaagggga gctgaaaagg ggacggggca acatc    atg aca aca    1914
                                                      Met Thr Thr
                                                        1

 gag aag agt tta gtg act gag gcc gaa aat tca cag cac caa cag aag     1962
 Glu Lys Ser Leu Val Thr Glu Ala Glu Asn Ser Gln His Gln Gln Lys
       5                  10                  15

 gaa gag ggt gag gaa gcc ata aac tca ggc caa caa gaa cct cag cag     2010
 Glu Glu Gly Glu Glu Ala Ile Asn Ser Gly Gln Gln Glu Pro Gln Gln
  20                  25                  30                  35

 gag gaa tct tgt caa aca gca gct gaa gga gat aat tgg tgt gaa cag     2058
 Glu Glu Ser Cys Gln Thr Ala Ala Glu Gly Asp Asn Trp Cys Glu Gln
                  40                  45                  50

 aag ctg aaa gct tct aat gga gac act cct aca cat gaa gac ttg acc     2106
 Lys Leu Lys Ala Ser Asn Gly Asp Thr Pro Thr His Glu Asp Leu Thr
              55                  60                  65

 aag aac aag gag cgg aca tca gaa agc aga gga ctt tca cga cta ttc     2154
 Lys Asn Lys Glu Arg Thr Ser Glu Ser Arg Gly Leu Ser Arg Leu Phe
          70                  75                  80

 tcc tcg ttt ctc aaa agg ccc aaa tct cag gtg tcc gag gaa gaa ggc     2202
 Ser Ser Phe Leu Lys Arg Pro Lys Ser Gln Val Ser Glu Glu Glu Gly
      85                  90                  95

 aaa gaa gta gag tca gat aaa gaa aaa ggt gaa gga ggt cag aaa gag     2250
 Lys Glu Val Glu Ser Asp Lys Glu Lys Gly Glu Gly Gly Gln Lys Glu
 100                 105                 110                 115

 ata gaa ttt gga acc agt ctt gat gaa gag atc att tta aag gcc cca     2298
 Ile Glu Phe Gly Thr Ser Leu Asp Glu Glu Ile Ile Leu Lys Ala Pro
                 120                 125                 130

 att gca gct cct gaa ccg gaa ctc aaa aca gac cca tct ttg gat ctt     2346
 Ile Ala Ala Pro Glu Pro Glu Leu Lys Thr Asp Pro Ser Leu Asp Leu
             135                 140                 145

 cat tca tta agc agt gca gaa aca cag cct gct cag gaa gaa ctc aga     2394
 His Ser Leu Ser Ser Ala Glu Thr Gln Pro Ala Gln Glu Glu Leu Arg
         150                 155                 160

 gaa gat cca gat ttt gaa att aag gaa gga gaa gga ctt gaa gag tgc     2442
 Glu Asp Pro Asp Phe Glu Ile Lys Glu Gly Glu Gly Leu Glu Glu Cys
     165                 170                 175

 tcc aaa ata gaa gta aaa gaa gaa agc cct caa tca aaa gca gaa aca     2490
 Ser Lys Ile Glu Val Lys Glu Glu Ser Pro Gln Ser Lys Ala Glu Thr
 180                 185                 190                 195

 gaa tta aaa gct tcc caa aaa cca atc aga aaa cac agg aac atg cac     2538
 Glu Leu Lys Ala Ser Gln Lys Pro Ile Arg Lys His Arg Asn Met His
                 200                 205                 210

 tgc aag gtt tct ttg ttg gat gac aca gtt tat gaa tgt gtt gtg gag     2586
 Cys Lys Val Ser Leu Leu Asp Asp Thr Val Tyr Glu Cys Val Val Glu
             215                 220                 225

 aaa cat gct aag gga caa gat ttg ctt aaa cga gta tgt gag cat ctc     2634
 Lys His Ala Lys Gly Gln Asp Leu Leu Lys Arg Val Cys Glu His Leu
         230                 235                 240

 aat ctt ttg gaa gaa gac tat ttt ggt cta gcc att tgg gat aac gca     2682
 Asn Leu Leu Glu Glu Asp Tyr Phe Gly Leu Ala Ile Trp Asp Asn Ala
     245                 250                 255

 acc tct aag aca tgg ctg gat tcc gcc aaa gaa ata aaa aag cag gtt     2730
 Thr Ser Lys Thr Trp Leu Asp Ser Ala Lys Glu Ile Lys Lys Gln Val
 260                 265                 270                 275

 cgt ggt gtc cct tgg aat ttt aca ttt aat gta aag ttt tat cca cct     2778
 Arg Gly Val Pro Trp Asn Phe Thr Phe Asn Val Lys Phe Tyr Pro Pro
                 280                 285                 290

 gac cca gca cag tta aca gaa gac ata aca aga tat tat tta tgt ctt     2826
 Asp Pro Ala Gln Leu Thr Glu Asp Ile Thr Arg Tyr Tyr Leu Cys Leu
             295                 300                 305

 cag ctt cgg cag gac ata gtt gca gga cgt ctg ccc tgt tcc ttt gca     2874
 Gln Leu Arg Gln Asp Ile Val Ala Gly Arg Leu Pro Cys Ser Phe Ala
         310                 315                 320

 acc tta gca tta tta ggt tct tac acc atc cag tct gaa ctg gga gac     2922
 Thr Leu Ala Leu Leu Gly Ser Tyr Thr Ile Gln Ser Glu Leu Gly Asp
     325                 330                 335

 tac gac cca gaa ctc cat ggc gtg gat tat gtt agt gat ttt aaa ctg     2970
 Tyr Asp Pro Glu Leu His Gly Val Asp Tyr Val Ser Asp Phe Lys Leu
 340                 345                 350                 355

 gcc ccg aat cag acc aag gaa ctt gaa gag aag gtc atg gaa ctg cat     3018
 Ala Pro Asn Gln Thr Lys Glu Leu Glu Glu Lys Val Met Glu Leu His
                 360                 365                 370

 aag tca tac agg tcc atg act cca gct cag gct gac ttg gag ttt ctt     3066
 Lys Ser Tyr Arg Ser Met Thr Pro Ala Gln Ala Asp Leu Glu Phe Leu
             375                 380                 385

 gag aat gcc aaa aag ttg tct atg tat gga gtt gat ctt cat aaa gca     3114
 Glu Asn Ala Lys Lys Leu Ser Met Tyr Gly Val Asp Leu His Lys Ala
         390                 395                 400

 aag gac ttg gaa gga gta gat atc atc cta ggt gtc tgc tct agt ggc     3162
 Lys Asp Leu Glu Gly Val Asp Ile Ile Leu Gly Val Cys Ser Ser Gly
     405                 410                 415

 ctt ctg gtt tac aaa gat aag ctg aga att aac cgc ttc cct tgg ccc     3210
 Leu Leu Val Tyr Lys Asp Lys Leu Arg Ile Asn Arg Phe Pro Trp Pro
 420                 425                 430                 435

 aaa gtg ctg aag att tct tat aaa cgt agt agc ttt ttc atc aag att     3258
 Lys Val Leu Lys Ile Ser Tyr Lys Arg Ser Ser Phe Phe Ile Lys Ile
                 440                 445                 450

 cgg cct gga gag caa gag cag tat gaa agt acc atc gga ttc aaa ctt     3306
 Arg Pro Gly Glu Gln Glu Gln Tyr Glu Ser Thr Ile Gly Phe Lys Leu
             455                 460                 465

 ccc agt tac cga gca gct aag aaa tta tgg aaa gtc tgt gta gaa cat     3354
 Pro Ser Tyr Arg Ala Ala Lys Lys Leu Trp Lys Val Cys Val Glu His
         470                 475                 480

 cac acg ttt ttc aga ttg aca tct aca gac acc att ccc aaa agc aaa     3402
 His Thr Phe Phe Arg Leu Thr Ser Thr Asp Thr Ile Pro Lys Ser Lys
     485                 490                 495

 ttt ctt gcg cta gga tcc aaa ttt cga tac agt ggc cgg act caa gct     3450
 Phe Leu Ala Leu Gly Ser Lys Phe Arg Tyr Ser Gly Arg Thr Gln Ala
 500                 505                 510                 515

 cag acc agg caa gct agt gct cta att gac agg cct gcc cca cac ttc     3498
 Gln Thr Arg Gln Ala Ser Ala Leu Ile Asp Arg Pro Ala Pro His Phe
                 520                 525                 530

 gag cgt aca gca agt aaa cgg gcg tcc cgg agc ctc gat gga gca gca     3546
 Glu Arg Thr Ala Ser Lys Arg Ala Ser Arg Ser Leu Asp Gly Ala Ala
             535                 540                 545

 gct gtc gat tcg gca gac cga agt cct cgg ccc act tct gca cct gcc     3594
 Ala Val Asp Ser Ala Asp Arg Ser Pro Arg Pro Thr Ser Ala Pro Ala
         550                 555                 560

 att act cag ggt cag gtt gca gaa ggt ggc gtc cta gat gcc tct gct     3642
 Ile Thr Gln Gly Gln Val Ala Glu Gly Gly Val Leu Asp Ala Ser Ala
     565                 570                 575

 aaa aaa aca gtg gtc cct aaa gca cag aag gaa aca gtg aag gct gaa     3690
 Lys Lys Thr Val Val Pro Lys Ala Gln Lys Glu Thr Val Lys Ala Glu
 580                 585                 590                 595

 gtg aaa aag gaa gac gag cca cct gag caa gct gag cca gag ccc aca     3738
 Val Lys Lys Glu Asp Glu Pro Pro Glu Gln Ala Glu Pro Glu Pro Thr
                 600                 605                 610

 gaa gca tgg aag gat tta gac aag agt caa gag gag atc aaa aaa cat     3786
 Glu Ala Trp Lys Asp Leu Asp Lys Ser Gln Glu Glu Ile Lys Lys His
             615                 620                 625

 cat gcc agc atc agt gag ctg aaa aag aac ttc atg gag tct gta cca     3834
 His Ala Ser Ile Ser Glu Leu Lys Lys Asn Phe Met Glu Ser Val Pro
         630                 635                 640

 gaa cca cgg cct agt gaa tgg gat aaa cgc tta tcc act cac tca ccc     3882
 Glu Pro Arg Pro Ser Glu Trp Asp Lys Arg Leu Ser Thr His Ser Pro
     645                 650                 655

 ttc cga act ctt aac atc aat ggg caa atc ccc aca gga gaa gga cct     3930
 Phe Arg Thr Leu Asn Ile Asn Gly Gln Ile Pro Thr Gly Glu Gly Pro
 660                 665                 670                 675

 ccc ctg gtg aag aca caa act gtc acc atc tca gat aat gcc aat gct     3978
 Pro Leu Val Lys Thr Gln Thr Val Thr Ile Ser Asp Asn Ala Asn Ala
                 680                 685                 690

 gtg aaa agt gaa atc cca acc aaa gac gtc cct att gtc cac act gag     4026
 Val Lys Ser Glu Ile Pro Thr Lys Asp Val Pro Ile Val His Thr Glu
             695                 700                 705

 acc aag acc atc act tat gag gct gcc cag act gac gac aac agt gga     4074
 Thr Lys Thr Ile Thr Tyr Glu Ala Ala Gln Thr Asp Asp Asn Ser Gly
         710                 715                 720

 gac ttg gac cca gga gtc ttg ctg aca gct caa act atc aca tct gag     4122
 Asp Leu Asp Pro Gly Val Leu Leu Thr Ala Gln Thr Ile Thr Ser Glu
     725                 730                 735

 acc cca agc agc acc acc aca act aaa att acc aag act gta aaa ggt     4170
 Thr Pro Ser Ser Thr Thr Thr Thr Lys Ile Thr Lys Thr Val Lys Gly
 740                 745                 750                 755

 ggg att tca gag aca cgt att gaa aag aga att gtg atc aca gga gat     4218
 Gly Ile Ser Glu Thr Arg Ile Glu Lys Arg Ile Val Ile Thr Gly Asp
                 760                 765                 770

 gct gat att gac cat gat cag gtc ctt gta caa gcc atc aag gag gca     4266
 Ala Asp Ile Asp His Asp Gln Val Leu Val Gln Ala Ile Lys Glu Ala
             775                 780                 785

 aag gag cag cac cca gac atg tca gtg acc aag gtg gtc gtc cac cag     4314
 Lys Glu Gln His Pro Asp Met Ser Val Thr Lys Val Val Val His Gln
         790                 795                 800

 gag acc gag att gct gat gag tga                                     4338
 Glu Thr Glu Ile Ala Asp Glu 
     805                 810





      <210> 352
      <211> 2591
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2289)

      <400> 352
  atg aca aca gag aag agt tta gtg act gag gcc gaa aat tca cag cac      48
  Met Thr Thr Glu Lys Ser Leu Val Thr Glu Ala Glu Asn Ser Gln His
    1               5                  10                  15

 caa cag aag gaa gag ggt gag gaa gcc ata aac tca ggc caa caa gaa       96
 Gln Gln Lys Glu Glu Gly Glu Glu Ala Ile Asn Ser Gly Gln Gln Glu
              20                  25                  30

 cct cag cag gag gaa tct tgt caa aca gca gct gaa gga gat aat tgg      144
 Pro Gln Gln Glu Glu Ser Cys Gln Thr Ala Ala Glu Gly Asp Asn Trp
          35                  40                  45

 tgt gaa cag aag ctg aaa gct tct aat gga gac act cct aca cat gaa      192
 Cys Glu Gln Lys Leu Lys Ala Ser Asn Gly Asp Thr Pro Thr His Glu
      50                  55                  60

 gac ttg acc aag aac aag gag cgg aca tca gaa agc aga gga ctt tca      240
 Asp Leu Thr Lys Asn Lys Glu Arg Thr Ser Glu Ser Arg Gly Leu Ser
  65                  70                  75                  80

 cga cta ttc tcc tcg ttt ctc aaa agg ccc aaa tct cag gtg tcc gag      288
 Arg Leu Phe Ser Ser Phe Leu Lys Arg Pro Lys Ser Gln Val Ser Glu
                  85                  90                  95

 gaa gaa ggc aaa gaa gta gag tca gat aaa gaa aaa ggt gaa gga ggt      336
 Glu Glu Gly Lys Glu Val Glu Ser Asp Lys Glu Lys Gly Glu Gly Gly
             100                 105                 110

 cag aaa gag ata gaa ttt gga acc agt ctt gat gaa gag atc att tta      384
 Gln Lys Glu Ile Glu Phe Gly Thr Ser Leu Asp Glu Glu Ile Ile Leu
         115                 120                 125

 aag gcc cca att gca gct cct gaa ccg gaa ctc aaa aca gac cca tct      432
 Lys Ala Pro Ile Ala Ala Pro Glu Pro Glu Leu Lys Thr Asp Pro Ser
     130                 135                 140

 ttg gat ctt cat tca tta agc agt gca gaa aca cag cct gct cag gaa      480
 Leu Asp Leu His Ser Leu Ser Ser Ala Glu Thr Gln Pro Ala Gln Glu
 145                 150                 155                 160

 gaa ctc aga gaa gat cca gat ttt gaa att aag gaa gga gaa gga ctt      528
 Glu Leu Arg Glu Asp Pro Asp Phe Glu Ile Lys Glu Gly Glu Gly Leu
                 165                 170                 175

 gaa gag tgc tcc aaa ata gaa gta aaa gaa gaa agc cct caa tca aaa      576
 Glu Glu Cys Ser Lys Ile Glu Val Lys Glu Glu Ser Pro Gln Ser Lys
             180                 185                 190

 gca gaa aca gaa tta aaa gct tcc caa aaa cca atc aga aaa cac agg      624
 Ala Glu Thr Glu Leu Lys Ala Ser Gln Lys Pro Ile Arg Lys His Arg
         195                 200                 205

 aac atg cac tgc aag gtt tct ttg ttg gat gac aca gtt tat gaa tgt      672
 Asn Met His Cys Lys Val Ser Leu Leu Asp Asp Thr Val Tyr Glu Cys
     210                 215                 220

 gtt gtg gag aca tgg ctg gat tcc gcc aaa gaa ata aaa aag cag gtt      720
 Val Val Glu Thr Trp Leu Asp Ser Ala Lys Glu Ile Lys Lys Gln Val
 225                 230                 235                 240

 cgt ggt gtc cct tgg aat ttt aca ttt aat gta aag ttt tat cca cct      768
 Arg Gly Val Pro Trp Asn Phe Thr Phe Asn Val Lys Phe Tyr Pro Pro
                 245                 250                 255

 gac cca gca cag tta aca gaa gac ata aca aga tat tat tta tgt ctt      816
 Asp Pro Ala Gln Leu Thr Glu Asp Ile Thr Arg Tyr Tyr Leu Cys Leu
             260                 265                 270

 cag ctt cgg cag gac ata gtt gca gga cgt ctg ccc tgt tcc ttt gca      864
 Gln Leu Arg Gln Asp Ile Val Ala Gly Arg Leu Pro Cys Ser Phe Ala
         275                 280                 285

 acc tta gca tta tta ggt tct tac acc atc cag tct gaa ctg gga gac      912
 Thr Leu Ala Leu Leu Gly Ser Tyr Thr Ile Gln Ser Glu Leu Gly Asp
     290                 295                 300

 tac gac cca gaa ctc cat ggc gtg gat tat gtt agt gat ttt aaa ctg      960
 Tyr Asp Pro Glu Leu His Gly Val Asp Tyr Val Ser Asp Phe Lys Leu
 305                 310                 315                 320

 gcc ccg aat cag acc aag gaa ctt gaa gag aag gtc atg gaa ctg cat     1008
 Ala Pro Asn Gln Thr Lys Glu Leu Glu Glu Lys Val Met Glu Leu His
                 325                 330                 335

 aag tca tac agg tcc atg act cca gct cag gct gac ttg gag ttt ctt     1056
 Lys Ser Tyr Arg Ser Met Thr Pro Ala Gln Ala Asp Leu Glu Phe Leu
             340                 345                 350

 gag aat gcc aaa aag ttg tct atg tat gga gtt gat ctt cat aaa gca     1104
 Glu Asn Ala Lys Lys Leu Ser Met Tyr Gly Val Asp Leu His Lys Ala
         355                 360                 365

 aag gac ttg gaa gga gta gat atc atc cta ggt gtc tgc tct agt ggc     1152
 Lys Asp Leu Glu Gly Val Asp Ile Ile Leu Gly Val Cys Ser Ser Gly
     370                 375                 380

 ctt ctg gtt tac aaa gat aag ctg aga att aac cgc ttc cct tgg ccc     1200
 Leu Leu Val Tyr Lys Asp Lys Leu Arg Ile Asn Arg Phe Pro Trp Pro
 385                 390                 395                 400

 aaa gtg ctg aag att tct tat aaa cgt agt agc ttt ttc atc aag att     1248
 Lys Val Leu Lys Ile Ser Tyr Lys Arg Ser Ser Phe Phe Ile Lys Ile
                 405                 410                 415

 cgg cct gga gag caa gag cag tat gaa agt acc atc gga ttc aaa ctt     1296
 Arg Pro Gly Glu Gln Glu Gln Tyr Glu Ser Thr Ile Gly Phe Lys Leu
             420                 425                 430

 ccc agt tac cga gca gct aag aaa tta tgg aaa gtc tgt gta gaa cat     1344
 Pro Ser Tyr Arg Ala Ala Lys Lys Leu Trp Lys Val Cys Val Glu His
         435                 440                 445

 cac acg ttt ttc aga ttg aca tct aca gac acc att ccc aaa agc aaa     1392
 His Thr Phe Phe Arg Leu Thr Ser Thr Asp Thr Ile Pro Lys Ser Lys
     450                 455                 460

 ttt ctt gcg cta gga tcc aaa ttt cga tac agt ggc cgg act caa gct     1440
 Phe Leu Ala Leu Gly Ser Lys Phe Arg Tyr Ser Gly Arg Thr Gln Ala
 465                 470                 475                 480

 cag acc agg caa gct agt gct cta att gac agg cct gcc cca cac ttc     1488
 Gln Thr Arg Gln Ala Ser Ala Leu Ile Asp Arg Pro Ala Pro His Phe
                 485                 490                 495

 gag cgt aca gca agt aaa cgg gcg tcc cgg agc ctc gat gga gca gca     1536
 Glu Arg Thr Ala Ser Lys Arg Ala Ser Arg Ser Leu Asp Gly Ala Ala
             500                 505                 510

 gct gtc gat tcg gca gac cga agt cct cgg ccc act tct gca cct gcc     1584
 Ala Val Asp Ser Ala Asp Arg Ser Pro Arg Pro Thr Ser Ala Pro Ala
         515                 520                 525

 att act cag ggt cag gtt gca gaa ggt ggc gtc cta gat gcc tct gct     1632
 Ile Thr Gln Gly Gln Val Ala Glu Gly Gly Val Leu Asp Ala Ser Ala
     530                 535                 540

 aaa aaa aca gtg gtc cct aaa gca cag aag gaa aca gtg aag gct gaa     1680
 Lys Lys Thr Val Val Pro Lys Ala Gln Lys Glu Thr Val Lys Ala Glu
 545                 550                 555                 560

 gtg aaa aag gaa gac gag cca cct gag caa gct gag cca gag ccc aca     1728
 Val Lys Lys Glu Asp Glu Pro Pro Glu Gln Ala Glu Pro Glu Pro Thr
                 565                 570                 575

 gaa gca tgg aag aaa aag aga gaa aga cta gat ggt gaa aac att tat     1776
 Glu Ala Trp Lys Lys Lys Arg Glu Arg Leu Asp Gly Glu Asn Ile Tyr
             580                 585                 590

 atc aga cat agc aat tta atg ttg gag gat tta gac aag agt caa gag     1824
 Ile Arg His Ser Asn Leu Met Leu Glu Asp Leu Asp Lys Ser Gln Glu
         595                 600                 605

 gag atc aaa aaa cat cat gcc agc atc agt gag ctg aaa aag aac ttc     1872
 Glu Ile Lys Lys His His Ala Ser Ile Ser Glu Leu Lys Lys Asn Phe
     610                 615                 620

 atg gag tct gta cca gaa cca cgg cct agt gaa tgg gat aaa cgc tta     1920
 Met Glu Ser Val Pro Glu Pro Arg Pro Ser Glu Trp Asp Lys Arg Leu
 625                 630                 635                 640

 tcc act cac tca ccc ttc cga act ctt aac atc aat ggg caa atc ccc     1968
 Ser Thr His Ser Pro Phe Arg Thr Leu Asn Ile Asn Gly Gln Ile Pro
                 645                 650                 655

 aca gga gaa gga cct ccc ctg gtg aag aca caa act gtc acc atc tca     2016
 Thr Gly Glu Gly Pro Pro Leu Val Lys Thr Gln Thr Val Thr Ile Ser
             660                 665                 670

 gat aat gcc aat gct gtg aaa agt gaa atc cca acc aaa gac gtc cct     2064
 Asp Asn Ala Asn Ala Val Lys Ser Glu Ile Pro Thr Lys Asp Val Pro
         675                 680                 685

 att gtc cac act gag acc aag acc atc act tat gag gct gcc cag act     2112
 Ile Val His Thr Glu Thr Lys Thr Ile Thr Tyr Glu Ala Ala Gln Thr
     690                 695                 700

 gta aaa ggt ggg att tca gag aca cgt att gaa aag aga att gtg atc     2160
 Val Lys Gly Gly Ile Ser Glu Thr Arg Ile Glu Lys Arg Ile Val Ile
 705                 710                 715                 720

 aca gga gat gct gat att gac cat gat cag gtc ctt gta caa gcc atc     2208
 Thr Gly Asp Ala Asp Ile Asp His Asp Gln Val Leu Val Gln Ala Ile
                 725                 730                 735

 aag gag gca aag gag cag cac cca gac atg tca gtg acc aag gtg gtc     2256
 Lys Glu Ala Lys Glu Gln His Pro Asp Met Ser Val Thr Lys Val Val
             740                 745                 750

 gtc cac cag gag acc gag att gct gat gag tga gctcagga actaacctac     2307
 Val His Gln Glu Thr Glu Ile Ala Asp Glu 
         755                 760

 cccaactctg cccttctccc atccaagaga aaccacgaaa atgataaaga agctaacctg   2367

 ccatagtcag acttcagact ttcaagatta ttctaaatca ccagaaaatt aatttcagtt   2427

 tctattggga gtttatacca agagattctt ctagatctca ttgatccttt tgaagagctt   2487

 tttctatatt aggatatcag aattgttcaa cttttcactc tatagactgt tttaagagtt   2547

 ttggggggtt tttaattggg tggtttgtaa ccccttcagc ctag                    2591




      <210> 353
      <211> 2696
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2394)

      <400> 353
  atg aca aca gag aag agt tta gtg act gag gcc gaa aat tca cag cac      48
  Met Thr Thr Glu Lys Ser Leu Val Thr Glu Ala Glu Asn Ser Gln His
    1               5                  10                  15

 caa cag aag gaa gag ggt gag gaa gcc ata aac tca ggc caa caa gaa       96
 Gln Gln Lys Glu Glu Gly Glu Glu Ala Ile Asn Ser Gly Gln Gln Glu
              20                  25                  30

 cct cag cag gag gaa tct tgt caa aca gca gct gaa gga gat aat tgg      144
 Pro Gln Gln Glu Glu Ser Cys Gln Thr Ala Ala Glu Gly Asp Asn Trp
          35                  40                  45

 tgt gaa cag aag ctg aaa gct tct aat gga gac act cct aca cat gaa      192
 Cys Glu Gln Lys Leu Lys Ala Ser Asn Gly Asp Thr Pro Thr His Glu
      50                  55                  60

 gac ttg acc aag aac aag gag cgg aca tca gaa agc aga gga ctt tca      240
 Asp Leu Thr Lys Asn Lys Glu Arg Thr Ser Glu Ser Arg Gly Leu Ser
  65                  70                  75                  80

 cga cta ttc tcc tcg ttt ctc aaa agg ccc aaa tct cag gtg tcc gag      288
 Arg Leu Phe Ser Ser Phe Leu Lys Arg Pro Lys Ser Gln Val Ser Glu
                  85                  90                  95

 gaa gaa ggc aaa gaa gta gag tca gat aaa gaa aaa ggt gaa gga ggt      336
 Glu Glu Gly Lys Glu Val Glu Ser Asp Lys Glu Lys Gly Glu Gly Gly
             100                 105                 110

 cag aaa gag ata gaa ttt gga acc agt ctt gat gaa gag atc att tta      384
 Gln Lys Glu Ile Glu Phe Gly Thr Ser Leu Asp Glu Glu Ile Ile Leu
         115                 120                 125

 aag gcc cca att gca gct cct gaa ccg gaa ctc aaa aca gac cca tct      432
 Lys Ala Pro Ile Ala Ala Pro Glu Pro Glu Leu Lys Thr Asp Pro Ser
     130                 135                 140

 ttg gat ctt cat tca tta agc agt gca gaa aca cag cct gct cag gaa      480
 Leu Asp Leu His Ser Leu Ser Ser Ala Glu Thr Gln Pro Ala Gln Glu
 145                 150                 155                 160

 gaa ctc aga gaa gat cca gat ttt gaa att aag gaa gga gaa gga ctt      528
 Glu Leu Arg Glu Asp Pro Asp Phe Glu Ile Lys Glu Gly Glu Gly Leu
                 165                 170                 175

 gaa gag tgc tcc aaa ata gaa gta aaa gaa gaa agc cct caa tca aaa      576
 Glu Glu Cys Ser Lys Ile Glu Val Lys Glu Glu Ser Pro Gln Ser Lys
             180                 185                 190

 gca gaa aca gaa tta aaa gct tcc caa aaa cca atc aga aaa cac agg      624
 Ala Glu Thr Glu Leu Lys Ala Ser Gln Lys Pro Ile Arg Lys His Arg
         195                 200                 205

 aac atg cac tgc aag gtt tct ttg ttg gat gac aca gtt tat gaa tgt      672
 Asn Met His Cys Lys Val Ser Leu Leu Asp Asp Thr Val Tyr Glu Cys
     210                 215                 220

 gtt gtg gag aaa cat gct aag gga caa gat ttg ctt aaa cga gta tgt      720
 Val Val Glu Lys His Ala Lys Gly Gln Asp Leu Leu Lys Arg Val Cys
 225                 230                 235                 240

 gag cat ctc aat ctt ttg gaa gaa gac tat ttt ggt cta gcc att tgg      768
 Glu His Leu Asn Leu Leu Glu Glu Asp Tyr Phe Gly Leu Ala Ile Trp
                 245                 250                 255

 gat aac gca acc tct aag aca tgg ctg gat tcc gcc aaa gaa ata aaa      816
 Asp Asn Ala Thr Ser Lys Thr Trp Leu Asp Ser Ala Lys Glu Ile Lys
             260                 265                 270

 aag cag gtt cgt ggt gtc cct tgg aat ttt aca ttt aat gta aag ttt      864
 Lys Gln Val Arg Gly Val Pro Trp Asn Phe Thr Phe Asn Val Lys Phe
         275                 280                 285

 tat cca cct gac cca gca cag tta aca gaa gac ata aca aga tat tat      912
 Tyr Pro Pro Asp Pro Ala Gln Leu Thr Glu Asp Ile Thr Arg Tyr Tyr
     290                 295                 300

 tta tgt ctt cag ctt cgg cag gac ata gtt gca gga cgt ctg ccc tgt      960
 Leu Cys Leu Gln Leu Arg Gln Asp Ile Val Ala Gly Arg Leu Pro Cys
 305                 310                 315                 320

 tcc ttt gca acc tta gca tta tta ggt tct tac acc atc cag tct gaa     1008
 Ser Phe Ala Thr Leu Ala Leu Leu Gly Ser Tyr Thr Ile Gln Ser Glu
                 325                 330                 335

 ctg gga gac tac gac cca gaa ctc cat ggc gtg gat tat gtt agt gat     1056
 Leu Gly Asp Tyr Asp Pro Glu Leu His Gly Val Asp Tyr Val Ser Asp
             340                 345                 350

 ttt aaa ctg gcc ccg aat cag acc aag gaa ctt gaa gag aag gtc atg     1104
 Phe Lys Leu Ala Pro Asn Gln Thr Lys Glu Leu Glu Glu Lys Val Met
         355                 360                 365

 gaa ctg cat aag tca tac agg tcc atg act cca gct cag gct gac ttg     1152
 Glu Leu His Lys Ser Tyr Arg Ser Met Thr Pro Ala Gln Ala Asp Leu
     370                 375                 380

 gag ttt ctt gag aat gcc aaa aag ttg tct atg tat gga gtt gat ctt     1200
 Glu Phe Leu Glu Asn Ala Lys Lys Leu Ser Met Tyr Gly Val Asp Leu
 385                 390                 395                 400

 cat aaa gca aag gac ttg gaa gga gta gat atc atc cta ggt gtc tgc     1248
 His Lys Ala Lys Asp Leu Glu Gly Val Asp Ile Ile Leu Gly Val Cys
                 405                 410                 415

 tct agt ggc ctt ctg gtt tac aaa gat aag ctg aga att aac cgc ttc     1296
 Ser Ser Gly Leu Leu Val Tyr Lys Asp Lys Leu Arg Ile Asn Arg Phe
             420                 425                 430

 cct tgg ccc aaa gtg ctg aag att tct tat aaa cgt agt agc ttt ttc     1344
 Pro Trp Pro Lys Val Leu Lys Ile Ser Tyr Lys Arg Ser Ser Phe Phe
         435                 440                 445

 atc aag att cgg cct gga gag caa gag cag tat gaa agt acc atc gga     1392
 Ile Lys Ile Arg Pro Gly Glu Gln Glu Gln Tyr Glu Ser Thr Ile Gly
     450                 455                 460

 ttc aaa ctt ccc agt tac cga gca gct aag aaa tta tgg aaa gtc tgt     1440
 Phe Lys Leu Pro Ser Tyr Arg Ala Ala Lys Lys Leu Trp Lys Val Cys
 465                 470                 475                 480

 gta gaa cat cac acg ttt ttc aga ttg aca tct aca gac acc att ccc     1488
 Val Glu His His Thr Phe Phe Arg Leu Thr Ser Thr Asp Thr Ile Pro
                 485                 490                 495

 aaa agc aaa ttt ctt gcg cta gga tcc aaa ttt cga tac agt ggc cgg     1536
 Lys Ser Lys Phe Leu Ala Leu Gly Ser Lys Phe Arg Tyr Ser Gly Arg
             500                 505                 510

 act caa gct cag acc agg caa gct agt gct cta att gac agg cct gcc     1584
 Thr Gln Ala Gln Thr Arg Gln Ala Ser Ala Leu Ile Asp Arg Pro Ala
         515                 520                 525

 cca cac ttc gag cgt aca gca agt aaa cgg gcg tcc cgg agc ctc gat     1632
 Pro His Phe Glu Arg Thr Ala Ser Lys Arg Ala Ser Arg Ser Leu Asp
     530                 535                 540

 gga gca gca gct gtc gat tcg gca gac cga agt cct cgg ccc act tct     1680
 Gly Ala Ala Ala Val Asp Ser Ala Asp Arg Ser Pro Arg Pro Thr Ser
 545                 550                 555                 560

 gca cct gcc att act cag ggt cag gtt gca gaa ggt ggc gtc cta gat     1728
 Ala Pro Ala Ile Thr Gln Gly Gln Val Ala Glu Gly Gly Val Leu Asp
                 565                 570                 575

 gcc tct gct aaa aaa aca gtg gtc cct aaa gca cag aag gaa aca gtg     1776
 Ala Ser Ala Lys Lys Thr Val Val Pro Lys Ala Gln Lys Glu Thr Val
             580                 585                 590

 aag gct gaa gtg aaa aag gaa gac gag cca cct gag caa gct gag cca     1824
 Lys Ala Glu Val Lys Lys Glu Asp Glu Pro Pro Glu Gln Ala Glu Pro
         595                 600                 605

 gag ccc aca gaa gca tgg aag aaa aag aga gaa aga cta gat ggt gaa     1872
 Glu Pro Thr Glu Ala Trp Lys Lys Lys Arg Glu Arg Leu Asp Gly Glu
     610                 615                 620

 aac att tat atc aga cat agc aat tta atg ttg gag gat tta gac aag     1920
 Asn Ile Tyr Ile Arg His Ser Asn Leu Met Leu Glu Asp Leu Asp Lys
 625                 630                 635                 640

 agt caa gag gag atc aaa aaa cat cat gcc agc atc agt gag ctg aaa     1968
 Ser Gln Glu Glu Ile Lys Lys His His Ala Ser Ile Ser Glu Leu Lys
                 645                 650                 655

 aag aac ttc atg gag tct gta cca gaa cca cgg cct agt gaa tgg gat     2016
 Lys Asn Phe Met Glu Ser Val Pro Glu Pro Arg Pro Ser Glu Trp Asp
             660                 665                 670

 aaa cgc tta tcc act cac tca ccc ttc cga act ctt aac atc aat ggg     2064
 Lys Arg Leu Ser Thr His Ser Pro Phe Arg Thr Leu Asn Ile Asn Gly
         675                 680                 685

 caa atc ccc aca gga gaa gga cct ccc ctg gtg aag aca caa act gtc     2112
 Gln Ile Pro Thr Gly Glu Gly Pro Pro Leu Val Lys Thr Gln Thr Val
     690                 695                 700

 acc atc tca gat aat gcc aat gct gtg aaa agt gaa atc cca acc aaa     2160
 Thr Ile Ser Asp Asn Ala Asn Ala Val Lys Ser Glu Ile Pro Thr Lys
 705                 710                 715                 720

 gac gtc cct att gtc cac act gag acc aag acc atc act tat gag gct     2208
 Asp Val Pro Ile Val His Thr Glu Thr Lys Thr Ile Thr Tyr Glu Ala
                 725                 730                 735

 gcc cag act gta aaa ggt ggg att tca gag aca cgt att gaa aag aga     2256
 Ala Gln Thr Val Lys Gly Gly Ile Ser Glu Thr Arg Ile Glu Lys Arg
             740                 745                 750

 att gtg atc aca gga gat gct gat att gac cat gat cag gtc ctt gta     2304
 Ile Val Ile Thr Gly Asp Ala Asp Ile Asp His Asp Gln Val Leu Val
         755                 760                 765

 caa gcc atc aag gag gca aag gag cag cac cca gac atg tca gtg acc     2352
 Gln Ala Ile Lys Glu Ala Lys Glu Gln His Pro Asp Met Ser Val Thr
     770                 775                 780

 aag gtg gtc gtc cac cag gag acc gag att gct gat gag tga gctcagg     2401
 Lys Val Val Val His Gln Glu Thr Glu Ile Ala Asp Glu 
 785                 790                 795

 aactaaccta ccccaactct gcccttctcc catccaagag aaaccacgaa aatgataaag   2461

 aagctaacct gccatagtca gacttcagac tttcaagatt attctaaatc accagaaaat   2521

 taatttcagt ttctattggg agtttatacc aagagattct tctagatctc attgatcctt   2581

 ttgaagagct ttttctatat taggatatca gaattgttca acttttcact ctatagactg   2641

 ttttaagagt tttggggggt ttttaattgg gtggtttgta accccttcag cctag        2696




      <210> 354
      <211> 2115
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (658)..(2115)

      <400> 354
 atgacagaca actgtatcat gtgcaaaatg acctcacaaa acaagggagg tgaactgagc     60

 tttcagcgca aactctttcc cccagcacca ccggcctctt atccaggcag tccacgccgg    120

 cccaggaacg ttcccagaac tacggctccc agcaggacaa gcgccagaca agcctggact    180

 caagaggata gactgggcaa aagcgcttct gggaatcgta gtttagggcg ccgacctcaa    240

 gatccaggct gggcacgcta cccgaccaac tccttacttg agctcttcag ccgaatacat    300

 cccgaaggaa atgccctgca gccgccgcca gggcatgttc ttggagatca acatcctcca    360

 gagaaatcaa agatggcggt tgtatctgct gttcgctggc tgggcctccg cagcaggctt    420

 ggccagccgc tgacgggtcg gcgggcgggt ttgtgtgaac aggcacgcag ctgcagattt    480

 tattctggta gtgcaaccct ctcaaaggtt gaaggaactg atgtaacagg gattgaagaa    540

 gtagtaattc caaaaaagaa aacttgggat aaagtagccg ttcttcaggc acttgcatcc    600

 acagtaaaca gggataccac agctgtgcct tatgtgtttc aagatgatcc ttacctt       657                                                                 
 atg cca gca tca tct ttg gaa tct tgt tta atg cct gag tac ttt gaa      705
 Met Pro Ala Ser Ser Leu Glu Ser Cys Leu Met Pro Glu Tyr Phe Glu
   1               5                  10                  15

 cct cag atc aaa gac ata agt gaa gcc gcc ctg aag gaa cga att gag      753
 Pro Gln Ile Lys Asp Ile Ser Glu Ala Ala Leu Lys Glu Arg Ile Glu
              20                  25                  30

 ctc aga aaa gtc aaa gcc tct gtg gac atg ttt gat cag ctt ttg caa      801
 Leu Arg Lys Val Lys Ala Ser Val Asp Met Phe Asp Gln Leu Leu Gln
          35                  40                  45

 gca gcc cca gct ctt gag gca gca ggc tac aga gcc aac act gac ctc      849
 Ala Ala Pro Ala Leu Glu Ala Ala Gly Tyr Arg Ala Asn Thr Asp Leu
      50                  55                  60

 tgc aat gcc aac caa gcc tgt att gct cta cgt cag cct cat ccc aga      897
 Cys Asn Ala Asn Gln Ala Cys Ile Ala Leu Arg Gln Pro His Pro Arg
  65                  70                  75                  80

 cct tgg ttt ata aat aaa gac aag att tat tct tgt aag aag tct tgc      945
 Pro Trp Phe Ile Asn Lys Asp Lys Ile Tyr Ser Cys Lys Lys Ser Cys
                  85                  90                  95

 cag gaa gag gaa aat gat gag aca tct agg agg aaa gct ggt cat cag      993
 Gln Glu Glu Glu Asn Asp Glu Thr Ser Arg Arg Lys Ala Gly His Gln
             100                 105                 110

 ttt gga gtt aca tgg cga gca aaa aac aac gct gag aga atc ttt tct     1041
 Phe Gly Val Thr Trp Arg Ala Lys Asn Asn Ala Glu Arg Ile Phe Ser
         115                 120                 125

 cta atg cca gag aaa aat gaa cat tcc tat tgc aca atg atc cga gga     1089
 Leu Met Pro Glu Lys Asn Glu His Ser Tyr Cys Thr Met Ile Arg Gly
     130                 135                 140

 atg gtg aag cac cga gct tat gag cag gca tta aac ttg tac act gag     1137
 Met Val Lys His Arg Ala Tyr Glu Gln Ala Leu Asn Leu Tyr Thr Glu
 145                 150                 155                 160

 tta cta aac aac aga ctc cat gct gat gta tac aca ttt aat gca ttg     1185
 Leu Leu Asn Asn Arg Leu His Ala Asp Val Tyr Thr Phe Asn Ala Leu
                 165                 170                 175

 att gaa gca aca gta tgt gcg ata aat gag aaa ttt gag gaa aaa tgg     1233
 Ile Glu Ala Thr Val Cys Ala Ile Asn Glu Lys Phe Glu Glu Lys Trp
             180                 185                 190

 agt aaa ata ctg gag ctg cta aga cac atg gtt gca cag aag gtg aaa     1281
 Ser Lys Ile Leu Glu Leu Leu Arg His Met Val Ala Gln Lys Val Lys
         195                 200                 205

 cca aat ctt cag act ttt aat acc att ctg aaa tgt ctc cga aga ttt     1329
 Pro Asn Leu Gln Thr Phe Asn Thr Ile Leu Lys Cys Leu Arg Arg Phe
     210                 215                 220

 cat gtg ttt gca aga tcg cca gcc tta cag gtt tta cgt gaa atg aaa     1377
 His Val Phe Ala Arg Ser Pro Ala Leu Gln Val Leu Arg Glu Met Lys
 225                 230                 235                 240

 gcc att gga ata gcc atg tgt cta gtg gct acc atg tgt cgt gat gca     1425
 Ala Ile Gly Ile Ala Met Cys Leu Val Ala Thr Met Cys Arg Asp Ala
                 245                 250                 255

 gat tca gaa cat ttc cat ctt tgc caa aag ttt gtg gac gtt tct gct     1473
 Asp Ser Glu His Phe His Leu Cys Gln Lys Phe Val Asp Val Ser Ala
             260                 265                 270

 cca gag gaa agt tcc aag ttc ttc gat ttg att tgt cta atg gaa caa     1521
 Pro Glu Glu Ser Ser Lys Phe Phe Asp Leu Ile Cys Leu Met Glu Gln
         275                 280                 285

 att gat gtt acc ttg aag tgg tat gag gac ctg ata cct tca gcc tac     1569
 Ile Asp Val Thr Leu Lys Trp Tyr Glu Asp Leu Ile Pro Ser Ala Tyr
     290                 295                 300

 ttt ccc cac tcc caa aca atg ata cat ctt ctc caa gca ttg gat gtg     1617
 Phe Pro His Ser Gln Thr Met Ile His Leu Leu Gln Ala Leu Asp Val
 305                 310                 315                 320

 gcc aat cgg cta gaa gtg att cct aaa att tgg aaa gat agt aaa gaa     1665
 Ala Asn Arg Leu Glu Val Ile Pro Lys Ile Trp Lys Asp Ser Lys Glu
                 325                 330                 335

 tat ggt cat act ttc cgc agt gac ctg aga gaa gag atc ctg atg ctc     1713
 Tyr Gly His Thr Phe Arg Ser Asp Leu Arg Glu Glu Ile Leu Met Leu
             340                 345                 350

 atg gca agg gac aag cac cca cca gag ggc tgg gag aac tca gga agc     1761
 Met Ala Arg Asp Lys His Pro Pro Glu Gly Trp Glu Asn Ser Gly Ser
         355                 360                 365

 ctg gtg agt aca gta cca caa gta tac act tta gaa gct ttt gta ttt     1809
 Leu Val Ser Thr Val Pro Gln Val Tyr Thr Leu Glu Ala Phe Val Phe
     370                 375                 380

 gaa tct aaa aca ttg gcc cac gct ggt aga ggt tct ttc att tgg cca     1857
 Glu Ser Lys Thr Leu Ala His Ala Gly Arg Gly Ser Phe Ile Trp Pro
 385                 390                 395                 400

 cat aac aca agt gag ttg ctg aat gag ctt atg gac agt gca aaa gtg     1905
 His Asn Thr Ser Glu Leu Leu Asn Glu Leu Met Asp Ser Ala Lys Val
                 405                 410                 415

 tct aac agc cct tcc cag gcc att gaa gta gta gag ctg gca agt gcc     1953
 Ser Asn Ser Pro Ser Gln Ala Ile Glu Val Val Glu Leu Ala Ser Ala
             420                 425                 430

 ttc agc tta cct att tgt gag ggc ctc acc cag aga gta atg agt gat     2001
 Phe Ser Leu Pro Ile Cys Glu Gly Leu Thr Gln Arg Val Met Ser Asp
         435                 440                 445

 ttt gca atc aac cag gaa caa aag gaa gcc cta agt aat cta act gca     2049
 Phe Ala Ile Asn Gln Glu Gln Lys Glu Ala Leu Ser Asn Leu Thr Ala
     450                 455                 460

 ttg acc agt gac agt gat act gac agc agc agt gac agc gac agt gac     2097
 Leu Thr Ser Asp Ser Asp Thr Asp Ser Ser Ser Asp Ser Asp Ser Asp
 465                 470                 475                 480

 acc agt gaa ggc aaa tga                                             2115
 Thr Ser Glu Gly Lys 
                 485





      <210> 355
      <211> 1102
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(900)

      <400> 355
  atg cgg cag ggg gac gtg gcc ggg tca ccg gct tcc agc agc agg tca      48
  Met Arg Gln Gly Asp Val Ala Gly Ser Pro Ala Ser Ser Ser Arg Ser
    1               5                  10                  15

 ggg ctg tcg aag cgg ctg cag tcg gcc acc atc acc gtg cgg acg ccc       96
 Gly Leu Ser Lys Arg Leu Gln Ser Ala Thr Ile Thr Val Arg Thr Pro
              20                  25                  30

 cgc acg cac ctg gaa ggc att gtt gag cca cag cac cga gca gga ggt      144
 Arg Thr His Leu Glu Gly Ile Val Glu Pro Gln His Arg Ala Gly Gly
          35                  40                  45

 gat atc tcc gat gcg gtg cag gtt ccc cga gat gag gct ggt ctc gtg      192
 Asp Ile Ser Asp Ala Val Gln Val Pro Arg Asp Glu Ala Gly Leu Val
      50                  55                  60

 cag tcc ttg gag cag gac gcg aac tgg tac ccg gaa tgg gag aag ctg      240
 Gln Ser Leu Glu Gln Asp Ala Asn Trp Tyr Pro Glu Trp Glu Lys Leu
  65                  70                  75                  80

 agg tgc agg acc tgg tct gtg tgt tcc cgc agc gtc tgc acc tcc acg      288
 Arg Cys Arg Thr Trp Ser Val Cys Ser Arg Ser Val Cys Thr Ser Thr
                  85                  90                  95

 cag ggc acc gtg tca tac agc cgc tgg aac tcc tcg tac cag gac atg      336
 Gln Gly Thr Val Ser Tyr Ser Arg Trp Asn Ser Ser Tyr Gln Asp Met
             100                 105                 110

 gcc gct gcg gct ggc tcg ctg ggc cag aag cct cag agg cca cgc cgg      384
 Ala Ala Ala Ala Gly Ser Leu Gly Gln Lys Pro Gln Arg Pro Arg Arg
         115                 120                 125

 ccc gca tcc ccc atc agc acc atc cag ccc aag gcc aat ttt gat gct      432
 Pro Ala Ser Pro Ile Ser Thr Ile Gln Pro Lys Ala Asn Phe Asp Ala
     130                 135                 140

 cag cag ttt gca ggg acc tgg ctc ctt gtg gct gtg ggc tcc gct tgc      480
 Gln Gln Phe Ala Gly Thr Trp Leu Leu Val Ala Val Gly Ser Ala Cys
 145                 150                 155                 160

 cgt ttc ctg cag gag cag ggc cac cgg gcc gag gcc acc aca ctg cat      528
 Arg Phe Leu Gln Glu Gln Gly His Arg Ala Glu Ala Thr Thr Leu His
                 165                 170                 175

 gtg gct ccc cag ggc aca gcc atg gct gtc agt acc ttc cga aag ctg      576
 Val Ala Pro Gln Gly Thr Ala Met Ala Val Ser Thr Phe Arg Lys Leu
             180                 185                 190

 gat ggg atc tgc tgg cag gtg cgc cag ctc tat gga gac aca ggg gtc      624
 Asp Gly Ile Cys Trp Gln Val Arg Gln Leu Tyr Gly Asp Thr Gly Val
         195                 200                 205

 ctc ggc cgc ttc ctg ctt caa gcc cga gac gcc cga ggg gct gtg cac      672
 Leu Gly Arg Phe Leu Leu Gln Ala Arg Asp Ala Arg Gly Ala Val His
     210                 215                 220

 gtg gtt gtc gct gag acc gac tac cag agt ttc gct gtc ctg tac ctg      720
 Val Val Val Ala Glu Thr Asp Tyr Gln Ser Phe Ala Val Leu Tyr Leu
 225                 230                 235                 240

 gag cgg gcg ggg cag ctg tca gtg aag ctc tac gcc cgc tcg ctc cct      768
 Glu Arg Ala Gly Gln Leu Ser Val Lys Leu Tyr Ala Arg Ser Leu Pro
                 245                 250                 255

 gtg agc gac tcg gtc ctg agt ggg ttt gag cag cgg gtc cag gag gcc      816
 Val Ser Asp Ser Val Leu Ser Gly Phe Glu Gln Arg Val Gln Glu Ala
             260                 265                 270

 cac ctg act gag gac cag atc ttc tac ttc ccc aag tac ggc ttc tgc      864
 His Leu Thr Glu Asp Gln Ile Phe Tyr Phe Pro Lys Tyr Gly Phe Cys
         275                 280                 285

 gag gct gca gac cag ttc cac gtc ctg gac aag tga ggag gtgaggccgg      914
 Glu Ala Ala Asp Gln Phe His Val Leu Asp Lys 
     290                 295

 cacacagctc cagtgctgag aagtcagtgc cccgagagac gaccccacca gtggggtgcc    974

 cgctgcctgt cctccgtgaa accagcctca gatcagggcc ctgccaccca gggcagggga   1034

 tcttctgccg gctgccccag aggacagtgg gtggagtggt acctacttat taaatgtctc   1094

 agacccct                                                            1102




      <210> 356
      <211> 1632
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1632)

      <400> 356
  atg agt cgg caa ctg aac atc aag tcc agt ggt gac aag ggc aac ttc      48
  Met Ser Arg Gln Leu Asn Ile Lys Ser Ser Gly Asp Lys Gly Asn Phe
    1               5                  10                  15

 agt gtg cat tcg gca gtg gtg cca agg aag gct gtg ggt agc ctg gct       96
 Ser Val His Ser Ala Val Val Pro Arg Lys Ala Val Gly Ser Leu Ala
              20                  25                  30

 tct tac tgt gca gct ggc aga ggg gct ggc gct ggc ttt ggc agt cgg      144
 Ser Tyr Cys Ala Ala Gly Arg Gly Ala Gly Ala Gly Phe Gly Ser Arg
          35                  40                  45

 agc ctc tat agc ctt gga ggg aat cgg cgt att tct ttc aat gtg gct      192
 Ser Leu Tyr Ser Leu Gly Gly Asn Arg Arg Ile Ser Phe Asn Val Ala
      50                  55                  60

 ggt ggc ggc gtt cgg gct gga ggt tac ggc ttc agg cct ggc tct ggg      240
 Gly Gly Gly Val Arg Ala Gly Gly Tyr Gly Phe Arg Pro Gly Ser Gly
  65                  70                  75                  80

 tat gga ggg ggc cgg gcc agt ggc ttt gct ggc agt atg ttt ggc agt      288
 Tyr Gly Gly Gly Arg Ala Ser Gly Phe Ala Gly Ser Met Phe Gly Ser
                  85                  90                  95

 gtg gcc ctg ggg cct gca tgt ttg tct gtg tgc cca cct ggg ggc atc      336
 Val Ala Leu Gly Pro Ala Cys Leu Ser Val Cys Pro Pro Gly Gly Ile
             100                 105                 110

 cac cag gtc act gtc aac aag agc ctc ttg gcc ccc ctc aac gtg gag      384
 His Gln Val Thr Val Asn Lys Ser Leu Leu Ala Pro Leu Asn Val Glu
         115                 120                 125

 ctg gac cct gag atc cag aag gtg cgc gcc cag gag cgg gaa cag atc      432
 Leu Asp Pro Glu Ile Gln Lys Val Arg Ala Gln Glu Arg Glu Gln Ile
     130                 135                 140

 aag gtg ctg aac gac aag ttc gcc tcc ttc att gac aag gta cgc ttc      480
 Lys Val Leu Asn Asp Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe
 145                 150                 155                 160

 cta gag cag cag aac cag gtt cta gaa acc aag tgg gag ctg ctg cag      528
 Leu Glu Gln Gln Asn Gln Val Leu Glu Thr Lys Trp Glu Leu Leu Gln
                 165                 170                 175

 cag ctg gac ctg aac aac tgc aag aag aac ctg gag ccc atc ctt gag      576
 Gln Leu Asp Leu Asn Asn Cys Lys Lys Asn Leu Glu Pro Ile Leu Glu
             180                 185                 190

 ggc tac atc agc aac ctg cgg aag cag ctg gag aca ctg tct ggg gac      624
 Gly Tyr Ile Ser Asn Leu Arg Lys Gln Leu Glu Thr Leu Ser Gly Asp
         195                 200                 205

 agg gtg agg ctg gac tcg gag ctg aga agc atg agg gat ctg gtg gag      672
 Arg Val Arg Leu Asp Ser Glu Leu Arg Ser Met Arg Asp Leu Val Glu
     210                 215                 220

 gac tat aag aag aga tat gag gtg gag att aac cgg cgc acg aca gca      720
 Asp Tyr Lys Lys Arg Tyr Glu Val Glu Ile Asn Arg Arg Thr Thr Ala
 225                 230                 235                 240

 gag aat gag ttt gtg gtg ctt aag aag gat gca gat gca gcc tac gca      768
 Glu Asn Glu Phe Val Val Leu Lys Lys Asp Ala Asp Ala Ala Tyr Ala
                 245                 250                 255

 gtc aag gtg gag ctt cag gcc aaa gtg gac tca ctg gac aaa gac atc      816
 Val Lys Val Glu Leu Gln Ala Lys Val Asp Ser Leu Asp Lys Asp Ile
             260                 265                 270

 aag ttc ctc aag tgt ctg tat gat gca gag atc gct cag atc cag act      864
 Lys Phe Leu Lys Cys Leu Tyr Asp Ala Glu Ile Ala Gln Ile Gln Thr
         275                 280                 285

 cac gcc agt gag acc tct gtc atc ctg tcc atg gac aac aac cgg gac      912
 His Ala Ser Glu Thr Ser Val Ile Leu Ser Met Asp Asn Asn Arg Asp
     290                 295                 300

 ctg gac ctt gac agc atc atc gct gag gtc cgc atg cat tat gag gag      960
 Leu Asp Leu Asp Ser Ile Ile Ala Glu Val Arg Met His Tyr Glu Glu
 305                 310                 315                 320

 atc gcc ctg aag agc aag gcc gag gcc gag gcc ctg tac cag acc aag     1008
 Ile Ala Leu Lys Ser Lys Ala Glu Ala Glu Ala Leu Tyr Gln Thr Lys
                 325                 330                 335

 tgc cct tgt ctc atc acc aac ttc cta tct ctg gga aac cag atc cag     1056
 Cys Pro Cys Leu Ile Thr Asn Phe Leu Ser Leu Gly Asn Gln Ile Gln
             340                 345                 350

 gag ctg cag ctg gca gcc agt cgg cat ggt gac gac ctg aaa cac acc     1104
 Glu Leu Gln Leu Ala Ala Ser Arg His Gly Asp Asp Leu Lys His Thr
         355                 360                 365

 agg agc gag atg gtg gag ctg aac cgg ctc atc cag agg atc cgg tgt     1152
 Arg Ser Glu Met Val Glu Leu Asn Arg Leu Ile Gln Arg Ile Arg Cys
     370                 375                 380

 gag atc ggg aat gtg aag aag cag cgt gcc agc ctg gag acg gcc atc     1200
 Glu Ile Gly Asn Val Lys Lys Gln Arg Ala Ser Leu Glu Thr Ala Ile
 385                 390                 395                 400

 gct gac gct gag cag cgg gga gac aat gcc ctg aag gat gcc cag gcc     1248
 Ala Asp Ala Glu Gln Arg Gly Asp Asn Ala Leu Lys Asp Ala Gln Ala
                 405                 410                 415

 aag ctg gat gag ctg gag ggc gcc ctg cac cag gcc aag gag gag ctg     1296
 Lys Leu Asp Glu Leu Glu Gly Ala Leu His Gln Ala Lys Glu Glu Leu
             420                 425                 430

 gcg cgg atg ctg cgc gag tac cag gag ctc atg agc ctg aaa ctg gcc     1344
 Ala Arg Met Leu Arg Glu Tyr Gln Glu Leu Met Ser Leu Lys Leu Ala
         435                 440                 445

 ctg gac atg gag att gcc acc tac cgc aag ctg ctg gag ggc gag gag     1392
 Leu Asp Met Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu
     450                 455                 460

 tgc agg atg tct ggt gag aat cca tcc tct gtg agc atc tct gtc atc     1440
 Cys Arg Met Ser Gly Glu Asn Pro Ser Ser Val Ser Ile Ser Val Ile
 465                 470                 475                 480

 agc agt agc agc tac agc tac cac cac ccc agc tct gcg ggt gtt gac     1488
 Ser Ser Ser Ser Tyr Ser Tyr His His Pro Ser Ser Ala Gly Val Asp
                 485                 490                 495

 ctt ggg gcc agc gct gtg gca ggc agc tct ggc agc acc cag agc ggg     1536
 Leu Gly Ala Ser Ala Val Ala Gly Ser Ser Gly Ser Thr Gln Ser Gly
             500                 505                 510

 cag acc aag acc aca gag gcg cga ggg gga gac ctc aag gac acc cag     1584
 Gln Thr Lys Thr Thr Glu Ala Arg Gly Gly Asp Leu Lys Asp Thr Gln
         515                 520                 525

 ggc aag agc acc cca gcc agc atc cca gca agg aaa gcc acc cgc tag     1632
 Gly Lys Ser Thr Pro Ala Ser Ile Pro Ala Arg Lys Ala Thr Arg 
     530                 535                 540





      <210> 357
      <211> 987
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (101)..(940)

      <400> 357
 gttcactttt gaagaaccaa atgacctcac tggtaaggtt ccctttggaa aacccccaac     60

 tatagcctcc gccgccgccg ccgcctcaaa attcaataaa  atg agc tct tat ttc     115
                                              Met Ser Ser Tyr Phe
                                                1               5

 gtc aac tca ctg ttc tcc aaa tac aaa acc ggg gag tcc ctg cgc ccc      163
 Val Asn Ser Leu Phe Ser Lys Tyr Lys Thr Gly Glu Ser Leu Arg Pro
                  10                  15                  20

 aat tat tat gac tgc ggc ttc gcc cag gac ctg ggc ggc cga ccc acc      211
 Asn Tyr Tyr Asp Cys Gly Phe Ala Gln Asp Leu Gly Gly Arg Pro Thr
              25                  30                  35

 gtg gtg tac ggt ccc agc agc ggc ggc agc ttc cag cac ccg tcg caa      259
 Val Val Tyr Gly Pro Ser Ser Gly Gly Ser Phe Gln His Pro Ser Gln
          40                  45                  50

 atc cag gag ttc tac cac ggg ccg tcg tcg ctg tcc acg gct ccc tac      307
 Ile Gln Glu Phe Tyr His Gly Pro Ser Ser Leu Ser Thr Ala Pro Tyr
      55                  60                  65

 cag cag aac ccg tgc gcc gtg gcg tgc cac ggg gac ccc ggc aat ttc      355
 Gln Gln Asn Pro Cys Ala Val Ala Cys His Gly Asp Pro Gly Asn Phe
  70                  75                  80                  85

 tac ggc tac gac ccg ctg caa cgc cag agc cta ttc ggt gcg cag gat      403
 Tyr Gly Tyr Asp Pro Leu Gln Arg Gln Ser Leu Phe Gly Ala Gln Asp
                  90                  95                 100

 cca gac ctg gtg cag tac gca gac tgc aag ctt gcc gcc gcc agc ggc      451
 Pro Asp Leu Val Gln Tyr Ala Asp Cys Lys Leu Ala Ala Ala Ser Gly
             105                 110                 115

 ctg ggc gag gag gcc gag ggc tcc gag cag agc ccg tcg ccc aca cag      499
 Leu Gly Glu Glu Ala Glu Gly Ser Glu Gln Ser Pro Ser Pro Thr Gln
         120                 125                 130

 ctc ttc ccc tgg atg cgc ccg caa gca gcc gcc gga cgc agg cga ggc      547
 Leu Phe Pro Trp Met Arg Pro Gln Ala Ala Ala Gly Arg Arg Arg Gly
     135                 140                 145

 cga cag acc tac agc cgc tac cag acc ctg gag ctg gag aag gag ttc      595
 Arg Gln Thr Tyr Ser Arg Tyr Gln Thr Leu Glu Leu Glu Lys Glu Phe
 150                 155                 160                 165

 cta ttt aat ccc tat ctg act cgt aag cgg cga atc gag gta tcg cac      643
 Leu Phe Asn Pro Tyr Leu Thr Arg Lys Arg Arg Ile Glu Val Ser His
                 170                 175                 180

 gcc ctg gga ctg aca gag aga cag gtc aaa atc tgg ttc cag aac cgg      691
 Ala Leu Gly Leu Thr Glu Arg Gln Val Lys Ile Trp Phe Gln Asn Arg
             185                 190                 195

 agg atg aag tgg aaa aaa gag aac aac aaa gac aag ttc ccc agc agc      739
 Arg Met Lys Trp Lys Lys Glu Asn Asn Lys Asp Lys Phe Pro Ser Ser
         200                 205                 210

 aaa tgc gag cag gag gag ctg gag aaa cag aag ctg gag cgg gcc cca      787
 Lys Cys Glu Gln Glu Glu Leu Glu Lys Gln Lys Leu Glu Arg Ala Pro
     215                 220                 225

 gag gcg gcg gac gag ggc gac gcg cag aag ggc gac aag aaa aac ggc      835
 Glu Ala Ala Asp Glu Gly Asp Ala Gln Lys Gly Asp Lys Lys Asn Gly
 230                 235                 240                 245

 agc gtc caa ggc ccg tgg gct gga tcc tgt gcc cta gga gca cct agg      883
 Ser Val Gln Gly Pro Trp Ala Gly Ser Cys Ala Leu Gly Ala Pro Arg
                 250                 255                 260

 aag act tgc tcc atc tcc gcc cgc ata tct ggg gca cca aga gag aca      931
 Lys Thr Cys Ser Ile Ser Ala Arg Ile Ser Gly Ala Pro Arg Glu Thr
             265                 270                 275

 gag tcg tga gccaggc tcgcctcatt cctcgtcttg ggagaaccgg accaacttcc      987
 Glu Ser 






      <210> 358
      <211> 1032
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1032)

      <400> 358
  atg ctt gtg ctt cat aac tct cag aag ctg cag att ctg tat aaa tcc      48
  Met Leu Val Leu His Asn Ser Gln Lys Leu Gln Ile Leu Tyr Lys Ser
    1               5                  10                  15

 tta gaa aag agc atc cct gaa tcc ata aag gta tat ggc gcc att ttc       96
 Leu Glu Lys Ser Ile Pro Glu Ser Ile Lys Val Tyr Gly Ala Ile Phe
              20                  25                  30

 aac ata aaa gat aaa aac cct ttc aac atg gag gtg ctg gta gat gcc      144
 Asn Ile Lys Asp Lys Asn Pro Phe Asn Met Glu Val Leu Val Asp Ala
          35                  40                  45

 tgg cca gat tac cag atc gtc att acc cgg cct cag aaa cag gta gga      192
 Trp Pro Asp Tyr Gln Ile Val Ile Thr Arg Pro Gln Lys Gln Val Gly
      50                  55                  60

 gca ata gtt act gaa tat gag ggt agt cac tct cca gac gtt ctc tgc      240
 Ala Ile Val Thr Glu Tyr Glu Gly Ser His Ser Pro Asp Val Leu Cys
  65                  70                  75                  80

 atg gca atg agg gaa ctg aaa ctg agg agt ggt gag aag aac att gac      288
 Met Ala Met Arg Glu Leu Lys Leu Arg Ser Gly Glu Lys Asn Ile Asp
                  85                  90                  95

 act gtt gat gta tgc agg ttt tgg aag ggc tgt ttg gga gac agg gag      336
 Thr Val Asp Val Cys Arg Phe Trp Lys Gly Cys Leu Gly Asp Arg Glu
             100                 105                 110

 atg aaa gat gac cag gat cat tat acc aac act tac cac atc ttc acc      384
 Met Lys Asp Asp Gln Asp His Tyr Thr Asn Thr Tyr His Ile Phe Thr
         115                 120                 125

 aaa gct cct gac aaa tta gag gaa gtc ctg tca tac tcc aat gta atc      432
 Lys Ala Pro Asp Lys Leu Glu Glu Val Leu Ser Tyr Ser Asn Val Ile
     130                 135                 140

 agc tgg gag caa act ttg cag atc caa ggt tgc caa gag ggc ttg gat      480
 Ser Trp Glu Gln Thr Leu Gln Ile Gln Gly Cys Gln Glu Gly Leu Asp
 145                 150                 155                 160

 gaa gca ata aga aag gtt gca act tca aaa tca gtg cag gta gat tac      528
 Glu Ala Ile Arg Lys Val Ala Thr Ser Lys Ser Val Gln Val Asp Tyr
                 165                 170                 175

 atg aaa acc atc ctc ttt ata ccg gaa tta cca aag aaa cac aag acc      576
 Met Lys Thr Ile Leu Phe Ile Pro Glu Leu Pro Lys Lys His Lys Thr
             180                 185                 190

 tca agt aat gac aag atg gag tta ttt gaa gtg gat gat gat aac aag      624
 Ser Ser Asn Asp Lys Met Glu Leu Phe Glu Val Asp Asp Asp Asn Lys
         195                 200                 205

 gaa gga aac ttt tca aac atg ttc tta gat gct tca cat gca ggt ctt      672
 Glu Gly Asn Phe Ser Asn Met Phe Leu Asp Ala Ser His Ala Gly Leu
     210                 215                 220

 gtg aat gaa cac tgg gcc ttt ggg aaa aat gag agg agc ttg aaa tat      720
 Val Asn Glu His Trp Ala Phe Gly Lys Asn Glu Arg Ser Leu Lys Tyr
 225                 230                 235                 240

 att gaa cgc tgc ctc cag gat ttt cta gga ttt ggt gtg ctg ggt cca      768
 Ile Glu Arg Cys Leu Gln Asp Phe Leu Gly Phe Gly Val Leu Gly Pro
                 245                 250                 255

 gag ggc cag ctt gtc tct tgg att gtg atg gaa cag tcc tgt gag ttg      816
 Glu Gly Gln Leu Val Ser Trp Ile Val Met Glu Gln Ser Cys Glu Leu
             260                 265                 270

 aga atg ggt tat act gtc ccc aaa tac aga cac caa ggc aac atg ttg      864
 Arg Met Gly Tyr Thr Val Pro Lys Tyr Arg His Gln Gly Asn Met Leu
         275                 280                 285

 caa att ggt tat cat ctt gaa aag tat ctt tct cag aaa gaa atc cca      912
 Gln Ile Gly Tyr His Leu Glu Lys Tyr Leu Ser Gln Lys Glu Ile Pro
     290                 295                 300

 ttt tat ttc cat gtg gca gat aat aat gag aaa agc cta cag gca ctg      960
 Phe Tyr Phe His Val Ala Asp Asn Asn Glu Lys Ser Leu Gln Ala Leu
 305                 310                 315                 320

 aac aat ttg ggg ttt aag att tgt cct tgt ggc tgg cat cag tgg aaa     1008
 Asn Asn Leu Gly Phe Lys Ile Cys Pro Cys Gly Trp His Gln Trp Lys
                 325                 330                 335

 tgc acc ccc aag aaa tat tgt tga                                     1032
 Cys Thr Pro Lys Lys Tyr Cys 
             340





      <210> 359
      <211> 1533
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (235)..(1533)

      <400> 359
 acgtatttta gaaacttgaa aaagaaactg acccagaaca agctcatctt gaagggggag     60

 ttgataacct tactacattt gtgtgagtct cgggaccatg tggaactggc taaaaatgtc    120

 atttacaggt accatgcaga gaacaaaaat ttcactttgg gggagtataa atttggaccg    180

 ctttttgtga ggttgtgtta cgagttggat ctcgaggaat ctgcagtgga gctc  atg     237
                                                              Met
                                                                1

 aaa gac cag cat tta cga ggt ttc ttc tca gac tcc aca tca ttc aat      285
 Lys Asp Gln His Leu Arg Gly Phe Phe Ser Asp Ser Thr Ser Phe Asn
               5                  10                  15

 att ttg atg gat atg tta ttt atc aaa ggc aaa tat aaa agt gct ttg      333
 Ile Leu Met Asp Met Leu Phe Ile Lys Gly Lys Tyr Lys Ser Ala Leu
          20                  25                  30

 caa gta ttg ata gag atg aaa aac cta gat gtg aag ttc acc aaa gat      381
 Gln Val Leu Ile Glu Met Lys Asn Leu Asp Val Lys Phe Thr Lys Asp
      35                  40                  45

 acc tat gtt ctt gct ttt gca att tgc tac aaa ctg aat agc cct gag      429
 Thr Tyr Val Leu Ala Phe Ala Ile Cys Tyr Lys Leu Asn Ser Pro Glu
  50                  55                  60                  65

 tct ttc aaa atc tgt act aca tta aga gaa gaa gct cta ctc aaa gga      477
 Ser Phe Lys Ile Cys Thr Thr Leu Arg Glu Glu Ala Leu Leu Lys Gly
                  70                  75                  80

 gaa att ctc tcc agg aga gca tcc tgt ttc gct gtg gca tta gct ctg      525
 Glu Ile Leu Ser Arg Arg Ala Ser Cys Phe Ala Val Ala Leu Ala Leu
              85                  90                  95

 aat cag aat gag atg gca aaa gct gtg tcc att ttt tct caa atc atg      573
 Asn Gln Asn Glu Met Ala Lys Ala Val Ser Ile Phe Ser Gln Ile Met
         100                 105                 110

 aat cca gaa agc ata gcc tgc att aat tta aat att ata atc cat atc      621
 Asn Pro Glu Ser Ile Ala Cys Ile Asn Leu Asn Ile Ile Ile His Ile
     115                 120                 125

 cag tca aat atg ttg gaa aac ctg ata aag act cta aaa aat gct gca      669
 Gln Ser Asn Met Leu Glu Asn Leu Ile Lys Thr Leu Lys Asn Ala Ala
 130                 135                 140                 145

 gaa gga aat tta tca aaa ttt gtg aaa aga cat gtg ttc tcg gag gaa      717
 Glu Gly Asn Leu Ser Lys Phe Val Lys Arg His Val Phe Ser Glu Glu
                 150                 155                 160

 gtg ctg gcc aaa gtg agg gaa aaa gtg aag gat gtg cct gcc ctt gtg      765
 Val Leu Ala Lys Val Arg Glu Lys Val Lys Asp Val Pro Ala Leu Val
             165                 170                 175

 gcc aaa ttt gat gag atc tat ggg aca ctg cac atc act ggc cag gtc      813
 Ala Lys Phe Asp Glu Ile Tyr Gly Thr Leu His Ile Thr Gly Gln Val
         180                 185                 190

 acc act gat tct ttg gat gct gtg ctc tgc cac acc ccc agg gac agg      861
 Thr Thr Asp Ser Leu Asp Ala Val Leu Cys His Thr Pro Arg Asp Arg
     195                 200                 205

 aaa tct cac acg ttg cta tta aac aag agg atg tcc acc tat gga tct      909
 Lys Ser His Thr Leu Leu Leu Asn Lys Arg Met Ser Thr Tyr Gly Ser
 210                 215                 220                 225

 gag ggg cct gct tct agt gag tta tta cct ttc cta aga agc cag gta      957
 Glu Gly Pro Ala Ser Ser Glu Leu Leu Pro Phe Leu Arg Ser Gln Val
                 230                 235                 240

 tcg cac ttc agc aga cag tgt gct gac act tgg tct tct cct gaa att     1005
 Ser His Phe Ser Arg Gln Cys Ala Asp Thr Trp Ser Ser Pro Glu Ile
             245                 250                 255

 ccc aaa ttc act gaa tgg tta agg aaa cga tcc atg caa gag agg ccc     1053
 Pro Lys Phe Thr Glu Trp Leu Arg Lys Arg Ser Met Gln Glu Arg Pro
         260                 265                 270

 aat ctc aac tgt aga ctg tgt ccc aag acc aga gct cag gag gaa gaa     1101
 Asn Leu Asn Cys Arg Leu Cys Pro Lys Thr Arg Ala Gln Glu Glu Glu
     275                 280                 285

 agg aca gat gcc ctt gtt caa gat gac ttc ttc atg ggc atc gat aga     1149
 Arg Thr Asp Ala Leu Val Gln Asp Asp Phe Phe Met Gly Ile Asp Arg
 290                 295                 300                 305

 tac att ctt gaa aac cac cca aag tac cta gag gag acc cta gtg caa     1197
 Tyr Ile Leu Glu Asn His Pro Lys Tyr Leu Glu Glu Thr Leu Val Gln
                 310                 315                 320

 ctg tgc att gta caa caa ctg atg aga aag gtg aca agg aca ctt gga     1245
 Leu Cys Ile Val Gln Gln Leu Met Arg Lys Val Thr Arg Thr Leu Gly
             325                 330                 335

 gct gtc cat ttg ctc ccc aaa tgt gtc tcc caa tgc cca gca tct tat     1293
 Ala Val His Leu Leu Pro Lys Cys Val Ser Gln Cys Pro Ala Ser Tyr
         340                 345                 350

 gca gcc ttt gac atg agt aaa gtc cct caa ggt gtc tca cct tct ctg     1341
 Ala Ala Phe Asp Met Ser Lys Val Pro Gln Gly Val Ser Pro Ser Leu
     355                 360                 365

 aac atc agg ttc ctc atc tat aca cca aat tct cta tac aca tca ggt     1389
 Asn Ile Arg Phe Leu Ile Tyr Thr Pro Asn Ser Leu Tyr Thr Ser Gly
 370                 375                 380                 385

 tca tgc ccc agc ctg aat aaa gct ggc aaa ttc cct tcc ctg ttc atg     1437
 Ser Cys Pro Ser Leu Asn Lys Ala Gly Lys Phe Pro Ser Leu Phe Met
                 390                 395                 400

 cac aat gaa aac atc gtg gcc aga gtt gat gag gtg aag tcc aca atc     1485
 His Asn Glu Asn Ile Val Ala Arg Val Asp Glu Val Lys Ser Thr Ile
             405                 410                 415

 aac ttc ctg acg gag gtg ctg tgt ctg gcc atg acc aat gcc atg tga     1533
 Asn Phe Leu Thr Glu Val Leu Cys Leu Ala Met Thr Asn Ala Met 
         420                 425                 430





      <210> 360
      <211> 1382
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (672)..(1382)

      <400> 360
 atggataaat gtcagaaaca tgacgttgag tgtgagaagc cagatgcaaa cgaggactca     60

 ctgtgcaatt ctgtgcatgt acagtggcca gagaagggag cactggcttt gctttcatca    120

 ggccaaagat gcctttcttt gggaatacgt tcagtccgaa gaagacacct cctcggaagt    180

 cggcatctct ctccaacctg cattctttgg atcgatcaac ccgggaggtg gagctgggct    240

 tggaatacgg atccccgact atgaacctgg cagggcaaag cctgaagttt gaaaatggcc    300

 agtggatagc agagacaggg gttagtggcg gtgtggaccg gagggaggtt cagcgccttc    360

 gcaggcggaa ccagcagttg gaggaagaga acaatctctt gcggctgaaa gtggacatct    420

 tattagacat ggagagaatg tttaatacag aagaaattgg aaaaggatcc acatatatgc    480

 aaggtgtaaa tcttcaggtg cagataatag gagcagtgga gtttgcttat gcctcggccg    540

 ggaagattta cctgatgttt tcccaaaaga cctgcaagac actaatttat tcctaccaag    600

 taaaacatgg ctcaggaaaa cgaaactgga tcagtgtctc tctaaaacag cccaagaagc    660

 aggccaagga g atg gac aag gaa gat aaa tct ttg gcc ctg gtc aca ggc     710
              Met Asp Lys Glu Asp Lys Ser Leu Ala Leu Val Thr Gly
                1               5                  10

 cga att aag aaa tcc ggc aag aat gac tgc ggt ggc gcc cca gaa cct      758
 Arg Ile Lys Lys Ser Gly Lys Asn Asp Cys Gly Gly Ala Pro Glu Pro
      15                  20                  25

 ctc aca ggc ctc tca gct gct gct aat gcc cgc cga agc ccc gac gcc      806
 Leu Thr Gly Leu Ser Ala Ala Ala Asn Ala Arg Arg Ser Pro Asp Ala
  30                  35                  40                  45

 cgg ata agg cca ggg ctg ccg gac ccg ctg cgg gca ctg gag gac ccg      854
 Arg Ile Arg Pro Gly Leu Pro Asp Pro Leu Arg Ala Leu Glu Asp Pro
                  50                  55                  60

 ggg cta gag ggc gcc gct ctc gcc cgg ctc gcg cct cgg ctc ccg gaa      902
 Gly Leu Glu Gly Ala Ala Leu Ala Arg Leu Ala Pro Arg Leu Pro Glu
              65                  70                  75

 aag cag ctc tgt ccg ccg ttc ggc tgc gct cac ctc ctt tcc gct tcc      950
 Lys Gln Leu Cys Pro Pro Phe Gly Cys Ala His Leu Leu Ser Ala Ser
          80                  85                  90

 gtc atg gct gcc gcc gtc gct gct gcc ggt gca ggg gaa ccc cag tcc      998
 Val Met Ala Ala Ala Val Ala Ala Ala Gly Ala Gly Glu Pro Gln Ser
      95                 100                 105

 ccg gac gaa ttg ctc ccg aaa ggc gac gcg gag aag cct gag gag gag     1046
 Pro Asp Glu Leu Leu Pro Lys Gly Asp Ala Glu Lys Pro Glu Glu Glu
 110                 115                 120                 125

 ctg gag gag gac gac gat gag gag cta gat gag acc ctg tcg gag aga     1094
 Leu Glu Glu Asp Asp Asp Glu Glu Leu Asp Glu Thr Leu Ser Glu Arg
                 130                 135                 140

 cta tgg ggc ctg acg gag atg ttt ccg gag agg gtc cgg tcc gcg gcc     1142
 Leu Trp Gly Leu Thr Glu Met Phe Pro Glu Arg Val Arg Ser Ala Ala
             145                 150                 155

 gga gcc act ttt gat ctt tcc ctc ttt gtg gct cag aaa atg tac agg     1190
 Gly Ala Thr Phe Asp Leu Ser Leu Phe Val Ala Gln Lys Met Tyr Arg
         160                 165                 170

 ttt tcc agg gca gcc ttg tgg att ggg acc act tcc ttt atg atc ctg     1238
 Phe Ser Arg Ala Ala Leu Trp Ile Gly Thr Thr Ser Phe Met Ile Leu
     175                 180                 185

 gtt ctt ccc gtt gtc ttt gag acg gag aag ttg caa atg gag caa cag     1286
 Val Leu Pro Val Val Phe Glu Thr Glu Lys Leu Gln Met Glu Gln Gln
 190                 195                 200                 205

 cag caa ctg cag cag cgg cag ata ctt cta gga cct aac aca ggg ctc     1334
 Gln Gln Leu Gln Gln Arg Gln Ile Leu Leu Gly Pro Asn Thr Gly Leu
                 210                 215                 220

 tca gga gga atg cca ggg gct cta ccc tca ctt cct gga aag atc tag     1382
 Ser Gly Gly Met Pro Gly Ala Leu Pro Ser Leu Pro Gly Lys Ile 
             225                 230                 235





      <210> 361
      <211> 1754
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (426)..(1712)

      <220>
      <221> misc_feature
      <222> (1)...(1754)
      <223> n = a,t,c or g

      <400> 361
 tgcaaagtga gggaagggca ctgcacgatc ttgggctctg ctagctgaag aggtggtggc     60

 tccaggaagg agggctttgc ttgccccacc gcacctacac acactcttca ccaagggtct    120

 gtgaagtgtt cgtctcccac attggtggct tgtttcttta gccataggag gtctgtgaaa    180

 gcacccaggc accccctctc gccccgtgga accgcatcgc aaaggtagct cactggcccc    240

 ggggcgggtc cctggccgac aaacccgtaa ctcacagcag tgacgcttcc cgacgccccc    300

 cggccacatc cccacaggaa cgctacggcg cacagggcat tactgtgccc ccaccacaac    360

 cacataaaga aaatagctcc ccggattatg gtgcactgag aaggcatctg gaagcctggg    420

 ccctc    atg gca tcc aac gat aaa ggc atg gca ccc tcg ctg ggc tct     467
          Met Ala Ser Asn Asp Lys Gly Met Ala Pro Ser Leu Gly Ser
            1               5                  10

 ccc tgg gcc tcc cag atg ggg ccc tgg gat gcc atc ctc aag gct gtc      515
 Pro Trp Ala Ser Gln Met Gly Pro Trp Asp Ala Ile Leu Lys Ala Val
  15                  20                  25                  30

 aaa gac cag ctc ccg tct ctg gac tca gac tcc cct ttg gac agg gcc      563
 Lys Asp Gln Leu Pro Ser Leu Asp Ser Asp Ser Pro Leu Asp Arg Ala
                  35                  40                  45

 aga aca ccc act gag aat gca caa ttc cag tgc att gtg ata agc ctt      611
 Arg Thr Pro Thr Glu Asn Ala Gln Phe Gln Cys Ile Val Ile Ser Leu
              50                  55                  60

 cga ggg att ctg cat ttg tgg ttt ggg gtc cct gaa atg gct ctc aaa      659
 Arg Gly Ile Leu His Leu Trp Phe Gly Val Pro Glu Met Ala Leu Lys
          65                  70                  75

 gac gct cag acc aat agc cct agc cct ctc att tgt cca cag tcg gac      707
 Asp Ala Gln Thr Asn Ser Pro Ser Pro Leu Ile Cys Pro Gln Ser Asp
      80                  85                  90

 tat ggg gaa gag gag ctg ttc atc ttc cag cga aac caa acc tcc ctg      755
 Tyr Gly Glu Glu Glu Leu Phe Ile Phe Gln Arg Asn Gln Thr Ser Leu
  95                 100                 105                 110

 att cca gac ctg tcg gag gag ctg gct gaa gat cct gcc gat ggc gac      803
 Ile Pro Asp Leu Ser Glu Glu Leu Ala Glu Asp Pro Ala Asp Gly Asp
                 115                 120                 125

 aag tcc agg gcc tgg gtc gct gca gct gaa gag tcc ctt ccc gag cca      851
 Lys Ser Arg Ala Trp Val Ala Ala Ala Glu Glu Ser Leu Pro Glu Pro
             130                 135                 140

 gtt ctg gtg cct gca gaa ttg gcc aca gaa cct ggg tgc aga cag aac      899
 Val Leu Val Pro Ala Glu Leu Ala Thr Glu Pro Gly Cys Arg Gln Asn
         145                 150                 155

 aca agg aca aag gat gca tcc tct cag gaa gga aga gac cct ggc agg      947
 Thr Arg Thr Lys Asp Ala Ser Ser Gln Glu Gly Arg Asp Pro Gly Arg
     160                 165                 170

 cct ttt gaa agc tct ggt gaa gtc agc gct ctt ctt ggg atg gcc gag      995
 Pro Phe Glu Ser Ser Gly Glu Val Ser Ala Leu Leu Gly Met Ala Glu
 175                 180                 185                 190

 gag ccc ccc agg tgg ctg gaa ggc gac ctt gga agc ctg tct ttc aac     1043
 Glu Pro Pro Arg Trp Leu Glu Gly Asp Leu Gly Ser Leu Ser Phe Asn
                 195                 200                 205

 acc aaa gga tcc cag ggt cct ccc tgg gac cca cag gcc gaa gcc act     1091
 Thr Lys Gly Ser Gln Gly Pro Pro Trp Asp Pro Gln Ala Glu Ala Thr
             210                 215                 220

 ctc tcc tgc cat gaa gga gac cca aag gca gag ccc ctc agc act gcc     1139
 Leu Ser Cys His Glu Gly Asp Pro Lys Ala Glu Pro Leu Ser Thr Ala
         225                 230                 235

 tca caa gaa tct gtg aac cgc cgg gcc ctc cga cag gag aga agg aag     1187
 Ser Gln Glu Ser Val Asn Arg Arg Ala Leu Arg Gln Glu Arg Arg Lys
     240                 245                 250

 atg ata gag acg gac atc ctc cag aaa gtc acc cgg gat gcc tgc ggc     1235
 Met Ile Glu Thr Asp Ile Leu Gln Lys Val Thr Arg Asp Ala Cys Gly
 255                 260                 265                 270

 ccg acc agc agt gac aaa ggt ggg gtg aag gag gcg ccc tgc cac gct     1283
 Pro Thr Ser Ser Asp Lys Gly Gly Val Lys Glu Ala Pro Cys His Ala
                 275                 280                 285

 gcg gag tca gct ccc aga tcc aaa atg ccc ctc gtg gag cct ccg gag     1331
 Ala Glu Ser Ala Pro Arg Ser Lys Met Pro Leu Val Glu Pro Pro Glu
             290                 295                 300

 gga cca cca gtg ctc tcg ctc cag caa ctt gaa gcg tgg gat ttg gat     1379
 Gly Pro Pro Val Leu Ser Leu Gln Gln Leu Glu Ala Trp Asp Leu Asp
         305                 310                 315

 gac atc ctt cag agt ctg gcg gga caa gaa gac aac cag gga aat cgt     1427
 Asp Ile Leu Gln Ser Leu Ala Gly Gln Glu Asp Asn Gln Gly Asn Arg
     320                 325                 330

 gca cct gga act gtg tgg tgg gca gct gac cac cgc caa gtt caa gac     1475
 Ala Pro Gly Thr Val Trp Trp Ala Ala Asp His Arg Gln Val Gln Asp
 335                 340                 345                 350

 tgc atg gtg ccg agc gcc cac aac agg ctc atg gaa cag ctg gcc ctc     1523
 Cys Met Val Pro Ser Ala His Asn Arg Leu Met Glu Gln Leu Ala Leu
                 355                 360                 365

 ctg tgc acc acg cag tcc aag gcc tct gct tgt gcc cgg aag gtg cct     1571
 Leu Cys Thr Thr Gln Ser Lys Ala Ser Ala Cys Ala Arg Lys Val Pro
             370                 375                 380

 gcc gac act ccc cag gac acc aaa gag gca gat tca gga agc aga tgt     1619
 Ala Asp Thr Pro Gln Asp Thr Lys Glu Ala Asp Ser Gly Ser Arg Cys
         385                 390                 395

 gcc tca agg aag cgg ggc tcc cag gct ggg cca ggc cca cag ctg gcc     1667
 Ala Ser Arg Lys Arg Gly Ser Gln Ala Gly Pro Gly Pro Gln Leu Ala
     400                 405                 410

 cag ggc atg agg ctt aac gca gga gtc ccc cac cat ctt tat tga cct     1715
 Gln Gly Met Arg Leu Asn Ala Gly Val Pro His His Leu Tyr 
 415                 420                 425

 gcngcagatg gagctaccag accacctgtc cccagaaag                          1754




      <210> 362
      <211> 2301
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2301)

      <400> 362
  atg gct gcc gac ccc acc gag ctg cgg ctg ggc agc ctc ccc gtc ttc      48
  Met Ala Ala Asp Pro Thr Glu Leu Arg Leu Gly Ser Leu Pro Val Phe
    1               5                  10                  15

 acc cgc gac gac ttc gag ggc gac tgg cgc cta gtg gcc agc ggc ggc       96
 Thr Arg Asp Asp Phe Glu Gly Asp Trp Arg Leu Val Ala Ser Gly Gly
              20                  25                  30

 ttc agc cag gtg ttc cag gcg cgg cac agg cgc tgg cgg acg gag tac      144
 Phe Ser Gln Val Phe Gln Ala Arg His Arg Arg Trp Arg Thr Glu Tyr
          35                  40                  45

 gcc atc aag tgc gcc ccc tgc ctt cca ccc gac gcc gcc agc tct gat      192
 Ala Ile Lys Cys Ala Pro Cys Leu Pro Pro Asp Ala Ala Ser Ser Asp
      50                  55                  60

 gtg aat tac ctc att gaa gaa gct gcc aaa atg aag aag atc aag ttt      240
 Val Asn Tyr Leu Ile Glu Glu Ala Ala Lys Met Lys Lys Ile Lys Phe
  65                  70                  75                  80

 cag cac atc gtg tct atc tac ggg gtg tgc aag cag ccc ctg ggt att      288
 Gln His Ile Val Ser Ile Tyr Gly Val Cys Lys Gln Pro Leu Gly Ile
                  85                  90                  95

 gtg atg gag ttt atg gcc aac ggc tcc ctg gag aag gtg ctg tcc acc      336
 Val Met Glu Phe Met Ala Asn Gly Ser Leu Glu Lys Val Leu Ser Thr
             100                 105                 110

 cac agc ctc tgc tgg aag ctc agg ttc cgc atc atc cat gag acc agc      384
 His Ser Leu Cys Trp Lys Leu Arg Phe Arg Ile Ile His Glu Thr Ser
         115                 120                 125

 ttg gcc atg aac ttc ctg cac agc att aag ccg cct ctg ctc cac ctg      432
 Leu Ala Met Asn Phe Leu His Ser Ile Lys Pro Pro Leu Leu His Leu
     130                 135                 140

 gac ctc aag ccg ggc aac ata ctc ctg gac agc aac atg cat gtc aaa      480
 Asp Leu Lys Pro Gly Asn Ile Leu Leu Asp Ser Asn Met His Val Lys
 145                 150                 155                 160

 att tca gac ttc ggc ctg tcc aag tgg atg gaa cag tcc acc cgg atg      528
 Ile Ser Asp Phe Gly Leu Ser Lys Trp Met Glu Gln Ser Thr Arg Met
                 165                 170                 175

 cag tac atc gag agg tcg gct ctg cgg ggc atg ctc agc tac atc ccc      576
 Gln Tyr Ile Glu Arg Ser Ala Leu Arg Gly Met Leu Ser Tyr Ile Pro
             180                 185                 190

 cct gag atg ttc ctg gag agt aac aag gcc cca gga cct aaa tat gat      624
 Pro Glu Met Phe Leu Glu Ser Asn Lys Ala Pro Gly Pro Lys Tyr Asp
         195                 200                 205

 gtg tac agc ttt gca att gtc atc tgg gag cta ctc act cag aag aaa      672
 Val Tyr Ser Phe Ala Ile Val Ile Trp Glu Leu Leu Thr Gln Lys Lys
     210                 215                 220

 cca tac tca ggg ttc aac atg atg atg att att atc cga gtg gcg gca      720
 Pro Tyr Ser Gly Phe Asn Met Met Met Ile Ile Ile Arg Val Ala Ala
 225                 230                 235                 240

 ggc atg cgg ccc tcc cta cag cct gtc tct gac caa tgg cca agc gag      768
 Gly Met Arg Pro Ser Leu Gln Pro Val Ser Asp Gln Trp Pro Ser Glu
                 245                 250                 255

 gcc cag cag atg gtg gac ctg atg aaa cgc tgc tgg gac cag gac ccc      816
 Ala Gln Gln Met Val Asp Leu Met Lys Arg Cys Trp Asp Gln Asp Pro
             260                 265                 270

 aag aag agg cca tgc ttt cta gac att acc atc gag aca gac ata ctg      864
 Lys Lys Arg Pro Cys Phe Leu Asp Ile Thr Ile Glu Thr Asp Ile Leu
         275                 280                 285

 ctg tca ctg ctg cag agt cgt gtg gca gtc cca gag agc aag gcc ctg      912
 Leu Ser Leu Leu Gln Ser Arg Val Ala Val Pro Glu Ser Lys Ala Leu
     290                 295                 300

 gcc agg aag gtg tcc tgc aag ctg tcg ctg cgc cag ccc ggg gag gtt      960
 Ala Arg Lys Val Ser Cys Lys Leu Ser Leu Arg Gln Pro Gly Glu Val
 305                 310                 315                 320

 aat gag gac atc agc cag gaa ctg atg gac agt gca gac tca gga aac     1008
 Asn Glu Asp Ile Ser Gln Glu Leu Met Asp Ser Ala Asp Ser Gly Asn
                 325                 330                 335

 tac ctg aag cgg gcc ctt cag ctc tcc gac cgt aag aat ttg gtc ccg     1056
 Tyr Leu Lys Arg Ala Leu Gln Leu Ser Asp Arg Lys Asn Leu Val Pro
             340                 345                 350

 aga gat gag gaa ctg tgt atc tat gag aac aag gtc acc ccc ctc cac     1104
 Arg Asp Glu Glu Leu Cys Ile Tyr Glu Asn Lys Val Thr Pro Leu His
         355                 360                 365

 ttc ctg gtg gcc cag ggc agt gtg gag cag gtg agg ttg ctg ctg gcc     1152
 Phe Leu Val Ala Gln Gly Ser Val Glu Gln Val Arg Leu Leu Leu Ala
     370                 375                 380

 cac gag gta gac gtg gac tgc cag acg gcc tct gga tac acg ccc ctc     1200
 His Glu Val Asp Val Asp Cys Gln Thr Ala Ser Gly Tyr Thr Pro Leu
 385                 390                 395                 400

 ctg atc gcc gcc cag gac cag caa ccc gac ctc tgt gcc ctg ctt ttg     1248
 Leu Ile Ala Ala Gln Asp Gln Gln Pro Asp Leu Cys Ala Leu Leu Leu
                 405                 410                 415

 gca cat ggt gct gat gcc aac cga gtg gat gag gat ggc tgg gcc cca     1296
 Ala His Gly Ala Asp Ala Asn Arg Val Asp Glu Asp Gly Trp Ala Pro
             420                 425                 430

 ctg cac ttt gca gcc cag aat ggg gat gac ggc act gcg cgc ctg ctc     1344
 Leu His Phe Ala Ala Gln Asn Gly Asp Asp Gly Thr Ala Arg Leu Leu
         435                 440                 445

 ctg gac cac ggg gcc tgt gtg gat gcc cag gaa cgt gaa ggg tgg acc     1392
 Leu Asp His Gly Ala Cys Val Asp Ala Gln Glu Arg Glu Gly Trp Thr
     450                 455                 460

 cct ctt cac ctg gct gca cag aat aac ttt gag aat gtg gca cgg ctt     1440
 Pro Leu His Leu Ala Ala Gln Asn Asn Phe Glu Asn Val Ala Arg Leu
 465                 470                 475                 480

 ctg gtc tcc cgt cag gct gac ccc aac ctg cat gag gct gag ggc aag     1488
 Leu Val Ser Arg Gln Ala Asp Pro Asn Leu His Glu Ala Glu Gly Lys
                 485                 490                 495

 acc ccc ctc cat gtg gcc gcc tac ttt ggc cat gtt agc ctg gtc aag     1536
 Thr Pro Leu His Val Ala Ala Tyr Phe Gly His Val Ser Leu Val Lys
             500                 505                 510

 ctg ctg acc agc cag ggg gct gag ttg gat gct cag cag aga aac ctg     1584
 Leu Leu Thr Ser Gln Gly Ala Glu Leu Asp Ala Gln Gln Arg Asn Leu
         515                 520                 525

 aga aca cca ctg cac ctg gca gta gag cgg ggc aaa gtg agg gcc atc     1632
 Arg Thr Pro Leu His Leu Ala Val Glu Arg Gly Lys Val Arg Ala Ile
     530                 535                 540

 caa cac ctg ctg aag agt gga gcg gtc cct gat gcc ctt gac cag agc     1680
 Gln His Leu Leu Lys Ser Gly Ala Val Pro Asp Ala Leu Asp Gln Ser
 545                 550                 555                 560

 ggc tat ggc cca ctg cac act gca gct gcc agg ggc aaa tac ctg atc     1728
 Gly Tyr Gly Pro Leu His Thr Ala Ala Ala Arg Gly Lys Tyr Leu Ile
                 565                 570                 575

 tgc aag atg ctg ctc agg tac gga gcc agc ctt gag ctg ccc acc cac     1776
 Cys Lys Met Leu Leu Arg Tyr Gly Ala Ser Leu Glu Leu Pro Thr His
             580                 585                 590

 cag ggc tgg aca ccc ctg cat cta gca gcc tac aag ggc cac ctg gag     1824
 Gln Gly Trp Thr Pro Leu His Leu Ala Ala Tyr Lys Gly His Leu Glu
         595                 600                 605

 atc atc cat ctg ctg gca gag agc cac gca aac atg ggt gct ctt gga     1872
 Ile Ile His Leu Leu Ala Glu Ser His Ala Asn Met Gly Ala Leu Gly
     610                 615                 620

 gct gtg aac tgg act ccc ctg cac cta gct gca cgc cac ggg gag gag     1920
 Ala Val Asn Trp Thr Pro Leu His Leu Ala Ala Arg His Gly Glu Glu
 625                 630                 635                 640

 gcg gtg gtg tca gca ctg ctg cag tgt ggg gct gac ccc aat gct gca     1968
 Ala Val Val Ser Ala Leu Leu Gln Cys Gly Ala Asp Pro Asn Ala Ala
                 645                 650                 655

 gag cag tca ggc tgg aca ccc ctc cac ctg gcg gtc cag agg agc acc     2016
 Glu Gln Ser Gly Trp Thr Pro Leu His Leu Ala Val Gln Arg Ser Thr
             660                 665                 670

 ttc ctg agt gtc atc aac ctc cta gaa cat cac gca aat gtc cac gcc     2064
 Phe Leu Ser Val Ile Asn Leu Leu Glu His His Ala Asn Val His Ala
         675                 680                 685

 cgc aac aag gtg ggc tgg aca ccc gcc cac ctg gcc gcc ctc aag ggc     2112
 Arg Asn Lys Val Gly Trp Thr Pro Ala His Leu Ala Ala Leu Lys Gly
     690                 695                 700

 aac aca gcc atc ctc aaa gtg ctg gtc gag gca ggc gcc cag ctg gac     2160
 Asn Thr Ala Ile Leu Lys Val Leu Val Glu Ala Gly Ala Gln Leu Asp
 705                 710                 715                 720

 gtc cag gat gga gtg agc tgc aca ccc ctg caa ctg gcc ctc cgc agc     2208
 Val Gln Asp Gly Val Ser Cys Thr Pro Leu Gln Leu Ala Leu Arg Ser
                 725                 730                 735

 cga aag cag ggc atc atg tcc ttc cta gag ggc aag gag ccg tca gtg     2256
 Arg Lys Gln Gly Ile Met Ser Phe Leu Glu Gly Lys Glu Pro Ser Val
             740                 745                 750

 gcc act ctg ggt ggt tct aag cca gga gcc gag atg gaa att tag         2301
 Ala Thr Leu Gly Gly Ser Lys Pro Gly Ala Glu Met Glu Ile 
         755                 760                 765





      <210> 363
      <211> 734
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (309)..(734)

      <220>
      <221> misc_feature
      <222> (1)...(734)
      <223> n = a,t,c or g

      <400> 363
 atgcccgagt ttgcagccaa gattgggcta cagtcctctg aagacttggt tggggctaaa     60

 ggatctgctt ctgttctggc ctgtaagctg cagaacgaag atgtgaattt acacagtctg    120

 gctccaaagt cagtgtctnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    180

 nnnnnnnnnn nnnnnnnnnn aactgccctg atcttaggct cattttcaac agcttcaaca    240

 acttgcattt caacgacaag tccctagtgg tatatcggaa agcagtgcct ggacaatcgg    300

 atctccta atg cct ctg tta ccc cat ccc caa cat gta gaa tca aga act     350
          Met Pro Leu Leu Pro His Pro Gln His Val Glu Ser Arg Thr
            1               5                  10

 ggc cac cgg cgg tat cat ggc aac ctg aac ccg gct ccc caa gaa tat      398
 Gly His Arg Arg Tyr His Gly Asn Leu Asn Pro Ala Pro Gln Glu Tyr
  15                  20                  25                  30

 gaa agt gag gac gac tct tac gaa gtg ttg gat tta act gag tat gcg      446
 Glu Ser Glu Asp Asp Ser Tyr Glu Val Leu Asp Leu Thr Glu Tyr Ala
                  35                  40                  45

 cga aga cac cag tgg tgg aat cca gtg ttt ggc cac agt tcg gga tct      494
 Arg Arg His Gln Trp Trp Asn Pro Val Phe Gly His Ser Ser Gly Ser
              50                  55                  60

 atg gtg gaa aaa tac gca gta gct acc cag att att gct agt cat agt      542
 Met Val Glu Lys Tyr Ala Val Ala Thr Gln Ile Ile Ala Ser His Ser
          65                  70                  75

 ggc tac gtg cag att aac tgg aag aga gtt gaa aaa gat tca aac aaa      590
 Gly Tyr Val Gln Ile Asn Trp Lys Arg Val Glu Lys Asp Ser Asn Lys
      80                  85                  90

 gca aaa agg cag atg aag aaa cga gcg aac aaa gca gca ccg gaa atc      638
 Ala Lys Arg Gln Met Lys Lys Arg Ala Asn Lys Ala Ala Pro Glu Ile
  95                 100                 105                 110

 aac aat tta att gaa gaa gca ata gaa ttt atc aag cag cac att gtg      686
 Asn Asn Leu Ile Glu Glu Ala Ile Glu Phe Ile Lys Gln His Ile Val
                 115                 120                 125

 ata ccc ggt aga ttt gtg gga ggc ttt ttg ctc gga ctt gca tct taa      734
 Ile Pro Gly Arg Phe Val Gly Gly Phe Leu Leu Gly Leu Ala Ser 
             130                 135                 140





      <210> 364
      <211> 659
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (152)..(616)

      <400> 364
 ctggctatgt cagggtaccc atcgctgcag gcaatgtgca ggggtgtcca gcccgcctca     60

 tctcgctggt gaatgtcagc cccgtatttg accagcagct tcacgcattc caggtttcca    120

 gagagcacgg cttcatgcaa ggcggccagg c   atg cct agc aga act gcc cgc     172
                                      Met Pro Ser Arg Thr Ala Arg
                                        1               5

 tat gcc cgc tac agc cca cgg cag cgg cgg cgg cgg atg ctg gct gat      220
 Tyr Ala Arg Tyr Ser Pro Arg Gln Arg Arg Arg Arg Met Leu Ala Asp
          10                  15                  20

 cgc agc gtg cgt ttc cct aat gat gtc ctg ttc ttg gac cac atc cgg      268
 Arg Ser Val Arg Phe Pro Asn Asp Val Leu Phe Leu Asp His Ile Arg
      25                  30                  35

 cag ggt gac ctg gag cag gtg ggg cgc ttc atc cgg act cgg aaa gtc      316
 Gln Gly Asp Leu Glu Gln Val Gly Arg Phe Ile Arg Thr Arg Lys Val
  40                  45                  50                  55

 tcc ctg gcc acc atc cac ccc tca ggc ctg gcc gcc ttg cat gaa gcc      364
 Ser Leu Ala Thr Ile His Pro Ser Gly Leu Ala Ala Leu His Glu Ala
                  60                  65                  70

 gtg ctc tct gga aac ctg gaa tgc gtg aag ctg ctg gtc aaa tac ggg      412
 Val Leu Ser Gly Asn Leu Glu Cys Val Lys Leu Leu Val Lys Tyr Gly
              75                  80                  85

 gct gac att cac cag cga gat gag gcg ggc tgg aca ccc ctg cac att      460
 Ala Asp Ile His Gln Arg Asp Glu Ala Gly Trp Thr Pro Leu His Ile
          90                  95                 100

 gcc tgc agc gat ggg tac cct gac ata gcc agg tac ctt atc tcc ctg      508
 Ala Cys Ser Asp Gly Tyr Pro Asp Ile Ala Arg Tyr Leu Ile Ser Leu
     105                 110                 115

 gga gcg gac agg gat gca acc aac gac gat ggc gac ctg ccc tcc gac      556
 Gly Ala Asp Arg Asp Ala Thr Asn Asp Asp Gly Asp Leu Pro Ser Asp
 120                 125                 130                 135

 ctc atc gac ccg gac tac aag gag ctg gtg gag ctc ttc aaa ggg acc      604
 Leu Ile Asp Pro Asp Tyr Lys Glu Leu Val Glu Leu Phe Lys Gly Thr
                 140                 145                 150

 acg atg gac tga gcc agctttgccc gcccgccccc gcgcccaggg ccgcctccct      659
 Thr Met Asp 






      <210> 365
      <211> 616
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(366)

      <220>
      <221> misc_feature
      <222> (1)...(616)
      <223> n = a,t,c or g

      <400> 365
  atg gct tcc gca aag aag ggt ggc caa aag aaa aag ggc cgt tct gct      48
  Met Ala Ser Ala Lys Lys Gly Gly Gln Lys Lys Lys Gly Arg Ser Ala
    1               5                  10                  15

 atc aac gag gtg gtg acc caa gaa tac acc atc aac att cac aag cgc       96
 Ile Asn Glu Val Val Thr Gln Glu Tyr Thr Ile Asn Ile His Lys Arg
              20                  25                  30

 acc cat gga gtg cgc ttc aag aag tgt gcc cct tgg gca ctc aaa gag      144
 Thr His Gly Val Arg Phe Lys Lys Cys Ala Pro Trp Ala Leu Lys Glu
          35                  40                  45

 att cgg aaa ttt gcc atg aag gag atg gta gct cca gac atg tgc gtt      192
 Ile Arg Lys Phe Ala Met Lys Glu Met Val Ala Pro Asp Met Cys Val
      50                  55                  60

 gct acc agg ctc aac aaa gct gtc tgg gcc aaa gga ata agg aat gtg      240
 Ala Thr Arg Leu Asn Lys Ala Val Trp Ala Lys Gly Ile Arg Asn Val
  65                  70                  75                  80

 cca tac cga atc cgt gtg cgg ctg tcc aga aaa cgt aat gag gat gaa      288
 Pro Tyr Arg Ile Arg Val Arg Leu Ser Arg Lys Arg Asn Glu Asp Glu
                  85                  90                  95

 gat tca cca aat aag cta tat act ttg gtt acc tat gta cct gtt acc      336
 Asp Ser Pro Asn Lys Leu Tyr Thr Leu Val Thr Tyr Val Pro Val Thr
             100                 105                 110

 act ttc aaa agt aag ttc tcc atc cca taa a gccatttaaa ttcattagaa      387
 Thr Phe Lys Ser Lys Phe Ser Ile Pro 
         115                 120

 aaatgtcctt acctcttaaa atgtgaattc atctgttaag ctaggggtga cacacgtcat    447

 tgtacccttt ntaaattgtt ggtgtgggaa gatgctaaag aatgcanaac tgatccatat    507

 ctgggatgta aaaaggttgt ggtagaatgc ccagacccgt ctacttactt nctttacaga    567

 tctacagaca gtcaatgtgg atgagaacta atcgctgaac gtcagtctt                616




      <210> 366
      <211> 545
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (226)..(471)

      <400> 366
 ctcgccgtcc accactgctg ttttgctgcc gtcgcagacc cgccgctgac ttccatccct     60

 ccaatccagc agggcgcccg ctgtgctcct gatccaggga agcacccgtt gccactcctg    120

 atcgcgctaa aggcttgcca ttgttcctgc atggctaagt gcctggtttc gtcctaatca    180

 agctgaacac tagtcactgg gttccacggt tctcttctgt gaccc    atg gtt tct     234
                                                      Met Val Ser
                                                        1

 aat aga gct ata aca ctc act gca tgg ccc aag att cca ttc ctt gga      282
 Asn Arg Ala Ile Thr Leu Thr Ala Trp Pro Lys Ile Pro Phe Leu Gly
       5                  10                  15

 atc cgt gag gcc aag aac ccc agg tca gag aac atg agg ctt gcc acc      330
 Ile Arg Glu Ala Lys Asn Pro Arg Ser Glu Asn Met Arg Leu Ala Thr
  20                  25                  30                  35

 atc ttg gaa gtg gct tct gcc atc ttg gaa gcg gcc cac cac cgt ctt      378
 Ile Leu Glu Val Ala Ser Ala Ile Leu Glu Ala Ala His His Arg Leu
                  40                  45                  50

 gga agt ggc cca cca ccg tct tgg gag ctc tgg gag caa gga ccc ctt      426
 Gly Ser Gly Pro Pro Pro Ser Trp Glu Leu Trp Glu Gln Gly Pro Leu
              55                  60                  65

 ggt aac aag aac act gtt ttg aga aaa tcc ata gaa aaa gaa tga att      474
 Gly Asn Lys Asn Thr Val Leu Arg Lys Ser Ile Glu Lys Glu 
          70                  75                  80

 ccaaatagtt tgggtctaaa acttctagtt ctctctgtct ttctaagagg ccttattcct    534

 agggggctgg g                                                         545




      <210> 367
      <211> 1671
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1671)

      <400> 367
  atg gag agg gac agc cac ggg aat gca tct cca gca aga aca cct tca      48
  Met Glu Arg Asp Ser His Gly Asn Ala Ser Pro Ala Arg Thr Pro Ser
    1               5                  10                  15

 gct gga gca tct cca gcc cag gca tct cca gct ggg aca cct cca ggc       96
 Ala Gly Ala Ser Pro Ala Gln Ala Ser Pro Ala Gly Thr Pro Pro Gly
              20                  25                  30

 cgg gca tct cca gcc cag gca tct cca gcc cag gca tct cca gct ggg      144
 Arg Ala Ser Pro Ala Gln Ala Ser Pro Ala Gln Ala Ser Pro Ala Gly
          35                  40                  45

 aca cct ccg ggc cgg gca tct cca gcc cag gca tct cca gct ggt aca      192
 Thr Pro Pro Gly Arg Ala Ser Pro Ala Gln Ala Ser Pro Ala Gly Thr
      50                  55                  60

 cct cca ggc cgg gca tct cca ggc cgg gca tct cca gcc cag gca tct      240
 Pro Pro Gly Arg Ala Ser Pro Gly Arg Ala Ser Pro Ala Gln Ala Ser
  65                  70                  75                  80

 cca gcc cag gca tct cca gcc cag gca tct cca gcc cgg gca tct ccg      288
 Pro Ala Gln Ala Ser Pro Ala Gln Ala Ser Pro Ala Arg Ala Ser Pro
                  85                  90                  95

 gct ctg gca tca ctt tcc agg tcc tca tcc ggc agg tca tca tcc gcc      336
 Ala Leu Ala Ser Leu Ser Arg Ser Ser Ser Gly Arg Ser Ser Ser Ala
             100                 105                 110

 agg tca gcc tcg gtg aca acc tcc cca acc aga gtg tac ctt gtt aga      384
 Arg Ser Ala Ser Val Thr Thr Ser Pro Thr Arg Val Tyr Leu Val Arg
         115                 120                 125

 gca aca cca gtg ggg gct gta ccc atc cga tca tct cct gcc agg tca      432
 Ala Thr Pro Val Gly Ala Val Pro Ile Arg Ser Ser Pro Ala Arg Ser
     130                 135                 140

 gca cca gca acc agg gcc acc agg gag agc cca gtc cag ttc tgg cag      480
 Ala Pro Ala Thr Arg Ala Thr Arg Glu Ser Pro Val Gln Phe Trp Gln
 145                 150                 155                 160

 ggc cac aca ggg atc agg tac aag gag cag agg gag agc tgt ccc aag      528
 Gly His Thr Gly Ile Arg Tyr Lys Glu Gln Arg Glu Ser Cys Pro Lys
                 165                 170                 175

 cac gct gtt cgc tgt gac ggg gtg gtg gac tgc aag ctg aag agt gac      576
 His Ala Val Arg Cys Asp Gly Val Val Asp Cys Lys Leu Lys Ser Asp
             180                 185                 190

 gag ctg ggc tgc gtg agg ttt gac tgg gac aag tct ctg ctt aaa atc      624
 Glu Leu Gly Cys Val Arg Phe Asp Trp Asp Lys Ser Leu Leu Lys Ile
         195                 200                 205

 tac tct ggg tcc tcc cat cag tgg ctt ccc atc tgt agc agc aac tgg      672
 Tyr Ser Gly Ser Ser His Gln Trp Leu Pro Ile Cys Ser Ser Asn Trp
     210                 215                 220

 aat gac tcc tac tca gag aag acc tgc cag cag ctg ggt ttc gag agt      720
 Asn Asp Ser Tyr Ser Glu Lys Thr Cys Gln Gln Leu Gly Phe Glu Ser
 225                 230                 235                 240

 gct cac cgg aca acc gag gtt gcc cac agg gat ttt gcc aac agc ttc      768
 Ala His Arg Thr Thr Glu Val Ala His Arg Asp Phe Ala Asn Ser Phe
                 245                 250                 255

 tca atc ttg aga tac aac tcc acc atc cag gaa agc ctc cac agg tct      816
 Ser Ile Leu Arg Tyr Asn Ser Thr Ile Gln Glu Ser Leu His Arg Ser
             260                 265                 270

 gaa tgc cct tcc cag cgg tat atc tcc ctc cag tgt tcc cac tgc gga      864
 Glu Cys Pro Ser Gln Arg Tyr Ile Ser Leu Gln Cys Ser His Cys Gly
         275                 280                 285

 ctg agg gcc atg acc ggg cgg atc gtg gga ggg gcg ctg gcc tcg gat      912
 Leu Arg Ala Met Thr Gly Arg Ile Val Gly Gly Ala Leu Ala Ser Asp
     290                 295                 300

 agc aag tgg cct tgg caa gtg agt ctg cac ttc ggc acc acc cac atc      960
 Ser Lys Trp Pro Trp Gln Val Ser Leu His Phe Gly Thr Thr His Ile
 305                 310                 315                 320

 tgt gga ggc acg ctc att gac gcc cag tgg gtg ctc act gcc gcc cac     1008
 Cys Gly Gly Thr Leu Ile Asp Ala Gln Trp Val Leu Thr Ala Ala His
                 325                 330                 335

 tgc ttc ttc gtg acc cgg gag aag gtc ctg gag ggc tgg aag gtg tac     1056
 Cys Phe Phe Val Thr Arg Glu Lys Val Leu Glu Gly Trp Lys Val Tyr
             340                 345                 350

 gcg ggc acc agc aac ctg cac cag ttg cct gag gca gcc tcc att gcc     1104
 Ala Gly Thr Ser Asn Leu His Gln Leu Pro Glu Ala Ala Ser Ile Ala
         355                 360                 365

 gag atc atc atc aac agc aat tac acc gat gag gag gac gac tat gac     1152
 Glu Ile Ile Ile Asn Ser Asn Tyr Thr Asp Glu Glu Asp Asp Tyr Asp
     370                 375                 380

 atc gcc ctc atg cgg ctg tcc aag ccc ctg acc ctg tcc gct cac atc     1200
 Ile Ala Leu Met Arg Leu Ser Lys Pro Leu Thr Leu Ser Ala His Ile
 385                 390                 395                 400

 cac cct gct tgc ctc ccc atg cat gga cag acc ttt agc ctc aat gag     1248
 His Pro Ala Cys Leu Pro Met His Gly Gln Thr Phe Ser Leu Asn Glu
                 405                 410                 415

 acc tgc tgg atc aca ggc ttt ggc aag acc agg gag aca gat gac aag     1296
 Thr Cys Trp Ile Thr Gly Phe Gly Lys Thr Arg Glu Thr Asp Asp Lys
             420                 425                 430

 aca tcc ccc ttc ctc cgg gag gtg cag gtc aat ctc atc gac ttc aag     1344
 Thr Ser Pro Phe Leu Arg Glu Val Gln Val Asn Leu Ile Asp Phe Lys
         435                 440                 445

 aaa tgc aat gac tac ttg gtc tat gac agt tac ctt acc cca agg atg     1392
 Lys Cys Asn Asp Tyr Leu Val Tyr Asp Ser Tyr Leu Thr Pro Arg Met
     450                 455                 460

 atg tgt gct ggg gac ctt cgt ggg ggc aga gac tcc tgc cag gga gac     1440
 Met Cys Ala Gly Asp Leu Arg Gly Gly Arg Asp Ser Cys Gln Gly Asp
 465                 470                 475                 480

 agc ggg ggg cct ctt gtc tgt gag cag aac aac cgc tgg tac ctg gca     1488
 Ser Gly Gly Pro Leu Val Cys Glu Gln Asn Asn Arg Trp Tyr Leu Ala
                 485                 490                 495

 ggt gtc acc agc tgg ggc aca ggc tgt ggc cag aga aac aaa cct ggt     1536
 Gly Val Thr Ser Trp Gly Thr Gly Cys Gly Gln Arg Asn Lys Pro Gly
             500                 505                 510

 gtg tac acc aaa gtg aca gaa gtt ctt ccc tgg att tac agc aag atg     1584
 Val Tyr Thr Lys Val Thr Glu Val Leu Pro Trp Ile Tyr Ser Lys Met
         515                 520                 525

 gag gta aga tcc ctg cag cag gac act gca ccc agc agg ctg gga act     1632
 Glu Val Arg Ser Leu Gln Gln Asp Thr Ala Pro Ser Arg Leu Gly Thr
     530                 535                 540

 tcc tca ggt ggg gac cct gga gga gca ccc agg gtg tag                 1671
 Ser Ser Gly Gly Asp Pro Gly Gly Ala Pro Arg Val 
 545                 550                 555





      <210> 368
      <211> 930
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(930)

      <400> 368
  atg gca ggc atc tcc cgg ccc gat ccc cct gtc cgc gcc tgg ggc gcc      48
  Met Ala Gly Ile Ser Arg Pro Asp Pro Pro Val Arg Ala Trp Gly Ala
    1               5                  10                  15

 aga aaa ggg acc aac ttc cta gca cat gag aag atc tgg ttc gac aag       96
 Arg Lys Gly Thr Asn Phe Leu Ala His Glu Lys Ile Trp Phe Asp Lys
              20                  25                  30

 ttc aaa tat gac gac gca gaa agg aga ttc tac gag cag atg aac ggg      144
 Phe Lys Tyr Asp Asp Ala Glu Arg Arg Phe Tyr Glu Gln Met Asn Gly
          35                  40                  45

 cct gtg cga ggt gcc tcc cgc cag gag aac ggc gcc agc gtg atc ctc      192
 Pro Val Arg Gly Ala Ser Arg Gln Glu Asn Gly Ala Ser Val Ile Leu
      50                  55                  60

 cgt gac att gcg aga gcc aga gag aac atc cag aaa tcc ctg gct gga      240
 Arg Asp Ile Ala Arg Ala Arg Glu Asn Ile Gln Lys Ser Leu Ala Gly
  65                  70                  75                  80

 agc tca ggc ccc ggg gcc tcc agc ggc acc agc gga gac cac ggt gag      288
 Ser Ser Gly Pro Gly Ala Ser Ser Gly Thr Ser Gly Asp His Gly Glu
                  85                  90                  95

 ctc gtc gtc cgg att gcc agt ctg gaa gtg gag aac cag agt ctg cgt      336
 Leu Val Val Arg Ile Ala Ser Leu Glu Val Glu Asn Gln Ser Leu Arg
             100                 105                 110

 ggc gtg gta cag gag ctg cag cag gcc atc tcc aag ctg gag gcc cgg      384
 Gly Val Val Gln Glu Leu Gln Gln Ala Ile Ser Lys Leu Glu Ala Arg
         115                 120                 125

 ctg aac gtg ctg gag aag agc tcg cct ggc cac cgg gcc acg gcc cca      432
 Leu Asn Val Leu Glu Lys Ser Ser Pro Gly His Arg Ala Thr Ala Pro
     130                 135                 140

 cag acc cag cac gta tct ccc atg cgc caa gtg gag ccc cca gcc aag      480
 Gln Thr Gln His Val Ser Pro Met Arg Gln Val Glu Pro Pro Ala Lys
 145                 150                 155                 160

 aag cca gcc aca cca gca gag gat gac gag gat gat gac att gac ctg      528
 Lys Pro Ala Thr Pro Ala Glu Asp Asp Glu Asp Asp Asp Ile Asp Leu
                 165                 170                 175

 ttt ggc agt gac aat gag gag gag gac aag gag gcg gca cag ctg cgg      576
 Phe Gly Ser Asp Asn Glu Glu Glu Asp Lys Glu Ala Ala Gln Leu Arg
             180                 185                 190

 gag gag cgg cta cgg cag tac gcg gaa aaa aag gcc aaa aag cct gca      624
 Glu Glu Arg Leu Arg Gln Tyr Ala Glu Lys Lys Ala Lys Lys Pro Ala
         195                 200                 205

 ctg gtg gcc aag tcc tcc atc ctg ctg gat gtc aac cct tgg gat gat      672
 Leu Val Ala Lys Ser Ser Ile Leu Leu Asp Val Asn Pro Trp Asp Asp
     210                 215                 220

 gag acg gac atg gcc cag ctg gag gcc tgt gtg cgc tct atc cag ctg      720
 Glu Thr Asp Met Ala Gln Leu Glu Ala Cys Val Arg Ser Ile Gln Leu
 225                 230                 235                 240

 gac ggg ctg gtt tgg ggg gct tcc aag ctg gtg ccc gtg ggc tac ggt      768
 Asp Gly Leu Val Trp Gly Ala Ser Lys Leu Val Pro Val Gly Tyr Gly
                 245                 250                 255

 atc cgg aag cta caa att cag tgt ctg gtg gag gac gcc aag gtg ggg      816
 Ile Arg Lys Leu Gln Ile Gln Cys Leu Val Glu Asp Ala Lys Val Gly
             260                 265                 270

 aca aac ttg gtg gag gag gag atc ccc aag ttt gag gag cgc gtg caa      864
 Thr Asn Leu Val Glu Glu Glu Ile Pro Lys Phe Glu Glu Arg Val Gln
         275                 280                 285

 agt gtc gat atc cca gct ttc aac aaa att tta agc ctg agt gtg tgt      912
 Ser Val Asp Ile Pro Ala Phe Asn Lys Ile Leu Ser Leu Ser Val Cys
     290                 295                 300

 acg agg ggg cgt gcg tga                                              930
 Thr Arg Gly Arg Ala 
 305





      <210> 369
      <211> 612
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (169)..(534)

      <400> 369
 atggaggagg ctggggcatc aatggggatg gcacagggga ctctgacttg caggaaagac     60

 aatgagctca ccttttggtg ctttgtgttg gcggagctgt tgacacatcc tagagaacat    120

 gcccagcaga cagaggagcg gctgtgggat gaggagataa actcagag atg cag cat     177
                                                      Met Gln His
                                                        1

 cac aca ggt gct gga gtc tcc cag tcc ctg aga cac aag gta gca aag      225
 His Thr Gly Ala Gly Val Ser Gln Ser Leu Arg His Lys Val Ala Lys
       5                  10                  15

 aag gga aag gat gta gct ctc aga tat gat cca att tca ggt cat aat      273
 Lys Gly Lys Asp Val Ala Leu Arg Tyr Asp Pro Ile Ser Gly His Asn
  20                  25                  30                  35

 gcc ctt tat tgg tac cga cag agc ctg ggg cag ggc ctg gag ttt cca      321
 Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu Phe Pro
                  40                  45                  50

 att tac ttc caa ggc aag gat gca gca gac aaa tcg ggg ctt ccc cgt      369
 Ile Tyr Phe Gln Gly Lys Asp Ala Ala Asp Lys Ser Gly Leu Pro Arg
              55                  60                  65

 gat cgg ttc tct gca cag agg tct gag gga tcc atc tcc act ctg aag      417
 Asp Arg Phe Ser Ala Gln Arg Ser Glu Gly Ser Ile Ser Thr Leu Lys
          70                  75                  80

 ttc cag cgc aca cag cag ggg gac ttg gct gtg tat ctc tgt gcc agc      465
 Phe Gln Arg Thr Gln Gln Gly Asp Leu Ala Val Tyr Leu Cys Ala Ser
      85                  90                  95

 agc tca gcc aca gca cta ctg ctc cag tgt cag ctt ggt tcc cta gga      513
 Ser Ser Ala Thr Ala Leu Leu Leu Gln Cys Gln Leu Gly Ser Leu Gly
 100                 105                 110                 115

 aat ggg gtt tct aga acc tga at gctgacaaat aagagttgta tatgtgtata      566
 Asn Gly Val Ser Arg Thr 
                 120

 ccatgcaacc tgcgtttaaa aatgtatgta catggtgaag tgacta                   612




      <210> 370
      <211> 2110
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (71)..(2110)

      <400> 370
 gagcgtgaag ctgtccctgg atattgagat cgccacctac cgcaagctgc tggagggcga     60

 ggagtgcagg   atg tcc gga gaa tat acc aac tcc gtg agc att tcg gtc     109
              Met Ser Gly Glu Tyr Thr Asn Ser Val Ser Ile Ser Val
                1               5                  10

 atc aac agc tcc atg gcc ggg atg gca ggc aca ggg gct ggc ttt gga      157
 Ile Asn Ser Ser Met Ala Gly Met Ala Gly Thr Gly Ala Gly Phe Gly
      15                  20                  25

 ttc agc aat gct ggc acc tac ggc tac tgg ccc agc tct gtc agc ggg      205
 Phe Ser Asn Ala Gly Thr Tyr Gly Tyr Trp Pro Ser Ser Val Ser Gly
  30                  35                  40                  45

 ggc tac agc atg ctg cct ggg ggc tgt gtc act ggc agt ggg aac tgt      253
 Gly Tyr Ser Met Leu Pro Gly Gly Cys Val Thr Gly Ser Gly Asn Cys
                  50                  55                  60

 agc ccc cac aca cac cca gag ggt cag ccc cac tgg aag ttt cca ggg      301
 Ser Pro His Thr His Pro Glu Gly Gln Pro His Trp Lys Phe Pro Gly
              65                  70                  75

 gtg atc ttg gga gtg ata acc cca gta att gga ggc cag cag gtg gag      349
 Val Ile Leu Gly Val Ile Thr Pro Val Ile Gly Gly Gln Gln Val Glu
          80                  85                  90

 ata agg tcg cta agc cat gat aat gca gga ggg att cat ggg gag ttc      397
 Ile Arg Ser Leu Ser His Asp Asn Ala Gly Gly Ile His Gly Glu Phe
      95                 100                 105

 acg gtg gaa cag aca aaa atc tcg cac cgg tac ttg cga gcc atg agc      445
 Thr Val Glu Gln Thr Lys Ile Ser His Arg Tyr Leu Arg Ala Met Ser
 110                 115                 120                 125

 cgc caa ctg acc cat ttc ccc cgc ggg gag cgc ctg ggc ttc agc ggt      493
 Arg Gln Leu Thr His Phe Pro Arg Gly Glu Arg Leu Gly Phe Ser Gly
                 130                 135                 140

 tgc tcc gcg gtc ctc tct ggc ggg atc ggc agc agc tcc gcc tca ttc      541
 Cys Ser Ala Val Leu Ser Gly Gly Ile Gly Ser Ser Ser Ala Ser Phe
             145                 150                 155

 cgg gcc cgg gtc aag ggc tcg gcc tcc ttt ggc agc aag agc ctc tcc      589
 Arg Ala Arg Val Lys Gly Ser Ala Ser Phe Gly Ser Lys Ser Leu Ser
         160                 165                 170

 tgc ctt ggg ggc agc cga agc ctg gcg ctc agc gct gct gca cgg cgg      637
 Cys Leu Gly Gly Ser Arg Ser Leu Ala Leu Ser Ala Ala Ala Arg Arg
     175                 180                 185

 ggc ggc ggc cgc ctg ggc ggc ttc gtg ggc acc gcc ttc ggc agc gcc      685
 Gly Gly Gly Arg Leu Gly Gly Phe Val Gly Thr Ala Phe Gly Ser Ala
 190                 195                 200                 205

 ggg ctg ggg ccc aag tgt ccc tcc gtg tgc cca ccc ggg ggc atc cct      733
 Gly Leu Gly Pro Lys Cys Pro Ser Val Cys Pro Pro Gly Gly Ile Pro
                 210                 215                 220

 cag gtc acc gtc aac aag agc ctc ctg gcc ccg ctc aac gtg gag atg      781
 Gln Val Thr Val Asn Lys Ser Leu Leu Ala Pro Leu Asn Val Glu Met
             225                 230                 235

 gac ccc gag atc cag agg gtg cgc gcc cag gag cgg gag cag atc aag      829
 Asp Pro Glu Ile Gln Arg Val Arg Ala Gln Glu Arg Glu Gln Ile Lys
         240                 245                 250

 gcg cta aac aac aag ttc gcc tcc ttc atc gac aag gtg cgg ttc ctg      877
 Ala Leu Asn Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu
     255                 260                 265

 gag cag cag aat cag gtg cta gag acc aag tgg aac ctc cta cag cag      925
 Glu Gln Gln Asn Gln Val Leu Glu Thr Lys Trp Asn Leu Leu Gln Gln
 270                 275                 280                 285

 ctg gac ttg aac aac tgc agg aag aac ctg gag ccc att tat gag ggc      973
 Leu Asp Leu Asn Asn Cys Arg Lys Asn Leu Glu Pro Ile Tyr Glu Gly
                 290                 295                 300

 tac atc agc aac ctg cag aag cag ctg gag atg ctg tct ggg gac ggg     1021
 Tyr Ile Ser Asn Leu Gln Lys Gln Leu Glu Met Leu Ser Gly Asp Gly
             305                 310                 315

 gtg agg ctg gat tcg gag ctg agg aac atg cag gat ttg gtg gag gac     1069
 Val Arg Leu Asp Ser Glu Leu Arg Asn Met Gln Asp Leu Val Glu Asp
         320                 325                 330

 tac aag aag aga acc ctg gcc caa gcc ctg cat gga gaa cct aag gaa     1117
 Tyr Lys Lys Arg Thr Leu Ala Gln Ala Leu His Gly Glu Pro Lys Glu
     335                 340                 345

 gga gga gac acg gtc cct gac ctc aga gag cac aca gat tgt gag gac     1165
 Gly Gly Asp Thr Val Pro Asp Leu Arg Glu His Thr Asp Cys Glu Asp
 350                 355                 360                 365

 agg ctt aaa gaa cag ttt cag ata gcc acc aac aag aag aaa caa ata     1213
 Arg Leu Lys Glu Gln Phe Gln Ile Ala Thr Asn Lys Lys Lys Gln Ile
                 370                 375                 380

 tgg tat gag gtg gag att aac aga cgc aca gct gct gag aat gag ttt     1261
 Trp Tyr Glu Val Glu Ile Asn Arg Arg Thr Ala Ala Glu Asn Glu Phe
             385                 390                 395

 gtg gtg ctc aag aag gac gtg gat gct gct tac atg aat aag gtt gag     1309
 Val Val Leu Lys Lys Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu
         400                 405                 410

 ctc cag gcc aag gtg gac tcc ttg aca gat gag att aaa ttc ttc aag     1357
 Leu Gln Ala Lys Val Asp Ser Leu Thr Asp Glu Ile Lys Phe Phe Lys
     415                 420                 425

 tgc ctt tat gaa ggg gag atc act cag atc cag tcc cac atc agc gac     1405
 Cys Leu Tyr Glu Gly Glu Ile Thr Gln Ile Gln Ser His Ile Ser Asp
 430                 435                 440                 445

 acg tcc atc gtc ctg tca atg gac aac aac cgg gat ctg gac ctg gac     1453
 Thr Ser Ile Val Leu Ser Met Asp Asn Asn Arg Asp Leu Asp Leu Asp
                 450                 455                 460

 agc atc att gcc gag gtc cgt gcc cag tac gag gag att gcc cta aag     1501
 Ser Ile Ile Ala Glu Val Arg Ala Gln Tyr Glu Glu Ile Ala Leu Lys
             465                 470                 475

 agc aag gcc gag gct gag acc ctg tac cag acc aag atc cag gag ctg     1549
 Ser Lys Ala Glu Ala Glu Thr Leu Tyr Gln Thr Lys Ile Gln Glu Leu
         480                 485                 490

 cag gtc aca gca ggc cag cat ggg gat gac ctc aag ctc acc aag gct     1597
 Gln Val Thr Ala Gly Gln His Gly Asp Asp Leu Lys Leu Thr Lys Ala
     495                 500                 505

 gaa atc tct gag ctc aac cgc ctg atc cag agg atc cgc tca gag ata     1645
 Glu Ile Ser Glu Leu Asn Arg Leu Ile Gln Arg Ile Arg Ser Glu Ile
 510                 515                 520                 525

 ggg aat gtg aag aag cag tgt gcc gat ctg gag acg gcc atc gcc gac     1693
 Gly Asn Val Lys Lys Gln Cys Ala Asp Leu Glu Thr Ala Ile Ala Asp
                 530                 535                 540

 gct gaa cag cgg ggg gac tgc gcc ctg aaa gat gcc cgg gcc aag ctg     1741
 Ala Glu Gln Arg Gly Asp Cys Ala Leu Lys Asp Ala Arg Ala Lys Leu
             545                 550                 555

 gat gag ctg gag ggc gcc ctg cac cag gcc aag gag gag ctg gca cgg     1789
 Asp Glu Leu Glu Gly Ala Leu His Gln Ala Lys Glu Glu Leu Ala Arg
         560                 565                 570

 atg ctg cgt gag tac cag gag ctc gtg agc ctg aag ctg gcc ctg gat     1837
 Met Leu Arg Glu Tyr Gln Glu Leu Val Ser Leu Lys Leu Ala Leu Asp
     575                 580                 585

 atg gag atc gcc acc tac cgc aag ctg ctg gag agc gag gag tgc agg     1885
 Met Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Ser Glu Glu Cys Arg
 590                 595                 600                 605

 atg tct ggc gaa tat cca aat tct gtg agc atc tcc gtc atc agc agc     1933
 Met Ser Gly Glu Tyr Pro Asn Ser Val Ser Ile Ser Val Ile Ser Ser
                 610                 615                 620

 acc aat gct ggg gca gga ggg gct ggc ttc agc atg ggc ttt ggc gcc     1981
 Thr Asn Ala Gly Ala Gly Gly Ala Gly Phe Ser Met Gly Phe Gly Ala
             625                 630                 635

 tca agc agt tat agc tac aaa act gca gct gca gac gtc aag acc aaa     2029
 Ser Ser Ser Tyr Ser Tyr Lys Thr Ala Ala Ala Asp Val Lys Thr Lys
         640                 645                 650

 ggc agc tgt ggc agt gag ctc aag gat ccc ctt gcc aaa acc tcg ggg     2077
 Gly Ser Cys Gly Ser Glu Leu Lys Asp Pro Leu Ala Lys Thr Ser Gly
     655                 660                 665

 agc agc tgt gcc acc aaa aag gcc tcc aga tga                         2110
 Ser Ser Cys Ala Thr Lys Lys Ala Ser Arg 
 670                 675





      <210> 371
      <211> 3202
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (132)..(2579)

      <400> 371
 tctcaatctc tgatgtggag acaatacgta atggccatga ttccgagttg ctgcgtagcc     60

 tggcagagga gctccccctg gagcagggct tcaccattgt cttccatggc cgccgctcca    120

 acctggacct g atg gcc aac agt gtt gag gag gcc cag ata tgg atg cga     170
              Met Ala Asn Ser Val Glu Glu Ala Gln Ile Trp Met Arg
                1               5                  10

 ggg ctc cag ctg ttg gtg gat ctt gtc acc agc atg gac cat cag gag      218
 Gly Leu Gln Leu Leu Val Asp Leu Val Thr Ser Met Asp His Gln Glu
      15                  20                  25

 cgc ctg gac cag tat cgg cag gat gga gtc agg gtg ggg gtg atc tgg      266
 Arg Leu Asp Gln Tyr Arg Gln Asp Gly Val Arg Val Gly Val Ile Trp
  30                  35                  40                  45

 tgc cag ctg gtg gaa cag tgg gtg atg gcg tcc ctg ctg caa gac cag      314
 Cys Gln Leu Val Glu Gln Trp Val Met Ala Ser Leu Leu Gln Asp Gln
                  50                  55                  60

 ctg acc act gat cag gac ttg ctg ctg atg cag gaa ggc atg ccg atg      362
 Leu Thr Thr Asp Gln Asp Leu Leu Leu Met Gln Glu Gly Met Pro Met
              65                  70                  75

 cgc aag gtg agg tcc aaa agc tgg aag aag cta aga tac ttc aga ctt      410
 Arg Lys Val Arg Ser Lys Ser Trp Lys Lys Leu Arg Tyr Phe Arg Leu
          80                  85                  90

 cag aat gac ggc atg aca gtc tgg cat gca cgg cag gcc agg ggc agt      458
 Gln Asn Asp Gly Met Thr Val Trp His Ala Arg Gln Ala Arg Gly Ser
      95                 100                 105

 gcc aag ccc agc ttc tca atc tct gat gtg gag aca ata cgt aat ggc      506
 Ala Lys Pro Ser Phe Ser Ile Ser Asp Val Glu Thr Ile Arg Asn Gly
 110                 115                 120                 125

 cat gat tcc gag ttg ctg cgt agc ctg gca gag gag ctc ccc ctg gag      554
 His Asp Ser Glu Leu Leu Arg Ser Leu Ala Glu Glu Leu Pro Leu Glu
                 130                 135                 140

 cag ggc ttc acc att gtc ttc cat ggc cgc cgc tcc aac ctg gac ctg      602
 Gln Gly Phe Thr Ile Val Phe His Gly Arg Arg Ser Asn Leu Asp Leu
             145                 150                 155

 atg gcc aac agt gtt gag gag gcc cag ata tgg atg cga ggg ctc cag      650
 Met Ala Asn Ser Val Glu Glu Ala Gln Ile Trp Met Arg Gly Leu Gln
         160                 165                 170

 ctg ttg gtg gat ctt gtc acc agc atg gac cat cag gag cgc ctg gac      698
 Leu Leu Val Asp Leu Val Thr Ser Met Asp His Gln Glu Arg Leu Asp
     175                 180                 185

 caa tgg ctg agc gat tgg ttt caa cgt gga gac aaa aat cag gat ggt      746
 Gln Trp Leu Ser Asp Trp Phe Gln Arg Gly Asp Lys Asn Gln Asp Gly
 190                 195                 200                 205

 aag atg agt ttc caa gaa gtt cag cgg tta ttg cac cta atg aat gtg      794
 Lys Met Ser Phe Gln Glu Val Gln Arg Leu Leu His Leu Met Asn Val
                 210                 215                 220

 gaa atg gac caa gaa tat gcc ttc agt ctt ttt cag gca gca gac acg      842
 Glu Met Asp Gln Glu Tyr Ala Phe Ser Leu Phe Gln Ala Ala Asp Thr
             225                 230                 235

 tcc cag tct gga acc ctg gaa gga gaa gaa ttc gta cag ttc tat aag      890
 Ser Gln Ser Gly Thr Leu Glu Gly Glu Glu Phe Val Gln Phe Tyr Lys
         240                 245                 250

 gca ttg act aaa cgt gct gag gtg cag gaa ctg ttt gaa agt ttt tca      938
 Ala Leu Thr Lys Arg Ala Glu Val Gln Glu Leu Phe Glu Ser Phe Ser
     255                 260                 265

 gct gat ggg cag aag ctg act ctg ctg gaa ttt ttg gat ttc ctc caa      986
 Ala Asp Gly Gln Lys Leu Thr Leu Leu Glu Phe Leu Asp Phe Leu Gln
 270                 275                 280                 285

 gag gag cag aag gag aga gac tgc acc tct gag ctt gct ctg gaa ctc     1034
 Glu Glu Gln Lys Glu Arg Asp Cys Thr Ser Glu Leu Ala Leu Glu Leu
                 290                 295                 300

 att gac cgc tat gaa cct tca gac agt ggc aaa ctg cgg cat gtg ctg     1082
 Ile Asp Arg Tyr Glu Pro Ser Asp Ser Gly Lys Leu Arg His Val Leu
             305                 310                 315

 agt atg gat ggc ttc ctc agc tac ctc tgc tct aag gat gga gac atc     1130
 Ser Met Asp Gly Phe Leu Ser Tyr Leu Cys Ser Lys Asp Gly Asp Ile
         320                 325                 330

 ttc aac cca gcc tgc ctc ccc atc tat cag gat atg act caa ccc ctg     1178
 Phe Asn Pro Ala Cys Leu Pro Ile Tyr Gln Asp Met Thr Gln Pro Leu
     335                 340                 345

 aac cac tac ttc atc tgc tct tct cat aac acc tac cta gtg ggg gac     1226
 Asn His Tyr Phe Ile Cys Ser Ser His Asn Thr Tyr Leu Val Gly Asp
 350                 355                 360                 365

 cag ctt tgc ggc cag agc agc gtc gag gga tat ata cgg gcc ctg aag     1274
 Gln Leu Cys Gly Gln Ser Ser Val Glu Gly Tyr Ile Arg Ala Leu Lys
                 370                 375                 380

 cgg ggg tgc cgc tgc gtg gag gtg gat gta tgg gat gga cct agc ggg     1322
 Arg Gly Cys Arg Cys Val Glu Val Asp Val Trp Asp Gly Pro Ser Gly
             385                 390                 395

 gaa cct gtc gtt tac cac gga cac acc ctg acc tcc cgc atc ctg ttc     1370
 Glu Pro Val Val Tyr His Gly His Thr Leu Thr Ser Arg Ile Leu Phe
         400                 405                 410

 aaa gat gtc gtg gcc aca gta gca cag tat gcc ttc cag aca tca gac     1418
 Lys Asp Val Val Ala Thr Val Ala Gln Tyr Ala Phe Gln Thr Ser Asp
     415                 420                 425

 tac cca gtc atc ttg tcc ctg gag acc cac tgc agc tgg gag cag cag     1466
 Tyr Pro Val Ile Leu Ser Leu Glu Thr His Cys Ser Trp Glu Gln Gln
 430                 435                 440                 445

 cag acc atg gcc cgt cat ctg act gag atc ctg ggg gag cag ctg ctg     1514
 Gln Thr Met Ala Arg His Leu Thr Glu Ile Leu Gly Glu Gln Leu Leu
                 450                 455                 460

 agc acc acc ttg gat ggg gtg ctg ccc act cag ctg ccc tcg cct gag     1562
 Ser Thr Thr Leu Asp Gly Val Leu Pro Thr Gln Leu Pro Ser Pro Glu
             465                 470                 475

 gag ctt cgg agg aag atc ctg gtg aag ggg aag aag tta aca ctt gag     1610
 Glu Leu Arg Arg Lys Ile Leu Val Lys Gly Lys Lys Leu Thr Leu Glu
         480                 485                 490

 gaa gac ctg gaa tat gag gaa gag gaa gca gaa cct gag ttg gaa gag     1658
 Glu Asp Leu Glu Tyr Glu Glu Glu Glu Ala Glu Pro Glu Leu Glu Glu
     495                 500                 505

 tca gaa ttg gcg ctg gag tcc cag ttt gag act gag cct gag ccc cag     1706
 Ser Glu Leu Ala Leu Glu Ser Gln Phe Glu Thr Glu Pro Glu Pro Gln
 510                 515                 520                 525

 gag cag aac ctt cag aat aag gac aaa aag aag aaa tcc aag ccc atc     1754
 Glu Gln Asn Leu Gln Asn Lys Asp Lys Lys Lys Lys Ser Lys Pro Ile
                 530                 535                 540

 ttg tgt cca gcc ctc tct tcc ctg gtt atc tac ttg aag tct gtc tca     1802
 Leu Cys Pro Ala Leu Ser Ser Leu Val Ile Tyr Leu Lys Ser Val Ser
             545                 550                 555

 ttc cgc agc ttc aca cat tca aag gag cac tac cac ttc tac gag ata     1850
 Phe Arg Ser Phe Thr His Ser Lys Glu His Tyr His Phe Tyr Glu Ile
         560                 565                 570

 tca tct ttc tct gaa acc aag gcc aag cgc ctc atc aag gag gct ggc     1898
 Ser Ser Phe Ser Glu Thr Lys Ala Lys Arg Leu Ile Lys Glu Ala Gly
     575                 580                 585

 aat gag ttt gtg cag cac aat act tgg cag tta agc cgt gtg tat ccc     1946
 Asn Glu Phe Val Gln His Asn Thr Trp Gln Leu Ser Arg Val Tyr Pro
 590                 595                 600                 605

 agc ggc ctg agg aca gac tct tcc aac tac aac ccc cag gaa ctc tgg     1994
 Ser Gly Leu Arg Thr Asp Ser Ser Asn Tyr Asn Pro Gln Glu Leu Trp
                 610                 615                 620

 aat gca ggc tgc cag atg gtg gcc atg aat atg cag act gca ggg ctt     2042
 Asn Ala Gly Cys Gln Met Val Ala Met Asn Met Gln Thr Ala Gly Leu
             625                 630                 635

 gaa atg gac atc tgt gat ggg cat ttc cgc cag aat ggc ggc tgt ggc     2090
 Glu Met Asp Ile Cys Asp Gly His Phe Arg Gln Asn Gly Gly Cys Gly
         640                 645                 650

 tat gtg ctg aag cca gac ttc ctg cgt gat atc cag agt tct ttc cac     2138
 Tyr Val Leu Lys Pro Asp Phe Leu Arg Asp Ile Gln Ser Ser Phe His
     655                 660                 665

 cct gag aag ccc atc agc cct ttc aaa gcc cag act ctc tta atc cag     2186
 Pro Glu Lys Pro Ile Ser Pro Phe Lys Ala Gln Thr Leu Leu Ile Gln
 670                 675                 680                 685

 gtg atc agc ggt cag caa ctc ccc aaa gtg gac aag acc aaa gag ggg     2234
 Val Ile Ser Gly Gln Gln Leu Pro Lys Val Asp Lys Thr Lys Glu Gly
                 690                 695                 700

 tcc att gtg gat cca ctg gtg aaa gtg cag atc ttt ggc gtt cgt cta     2282
 Ser Ile Val Asp Pro Leu Val Lys Val Gln Ile Phe Gly Val Arg Leu
             705                 710                 715

 gac aca gca cgg cag gag acc aac tat gtg gag aac aat ggt ttt aat     2330
 Asp Thr Ala Arg Gln Glu Thr Asn Tyr Val Glu Asn Asn Gly Phe Asn
         720                 725                 730

 cca tac tgg ggg cag aca cta tgt ttc cgg gtg ctg gtg cct gaa ctt     2378
 Pro Tyr Trp Gly Gln Thr Leu Cys Phe Arg Val Leu Val Pro Glu Leu
     735                 740                 745

 gcc atg ctg cgt ttt gtg gta atg gat tat gac tgg aaa tcc cga aat     2426
 Ala Met Leu Arg Phe Val Val Met Asp Tyr Asp Trp Lys Ser Arg Asn
 750                 755                 760                 765

 gac ttt att ggt cag tac acc ctg cct tgg acc tgc atg caa caa ggt     2474
 Asp Phe Ile Gly Gln Tyr Thr Leu Pro Trp Thr Cys Met Gln Gln Gly
                 770                 775                 780

 tac cgc cac att cac ctg ctg tcc aaa gat ggc atc agc ctc cgc cca     2522
 Tyr Arg His Ile His Leu Leu Ser Lys Asp Gly Ile Ser Leu Arg Pro
             785                 790                 795

 gct tcc atc ttt gtg tat atc tgc atc cag gaa ggc ctg gag ggg gat     2570
 Ala Ser Ile Phe Val Tyr Ile Cys Ile Gln Glu Gly Leu Glu Gly Asp
         800                 805                 810

 gag tcc tga ggtgggc atttcacggg aagggttggt atgctggctt tagacgggga     2626
 Glu Ser 
     815

 gaaacatctg gaaggatgct cgagagaaca aatggaggtg gtgaaaatca agctttggat   2686

 tgtgcattcc taggcacaaa attacctcat tcttcctaac aagcaatctg ggacctgatt   2746

 ttccaccttt tttctctttt cttcccttcc tttgttttca taagcctttg gtatctttcc   2806

 tgcccttttc ctttgtgtac tctatactgg agttcccttc ttcctcttgc tgtaggctca   2866

 atcccatacc gacatctaca actaatcttt cccatcaact ctgtgtgaag gcaggttgca   2926

 actagaaatt cagaggggct tggaatagag aaacctaaag aagcatcatc ccctccatcc   2986

 ccaacttcct caaagcccaa agccaaggga aggataaatc aaggctcaag gcttccccag   3046

 caaagattag ggaaagagac ttgaccccag gactgtacta cgactcttaa gagaacactg   3106

 cacagcactc aaagtccccc actggactgc ttcctcctta gccccactgg tataaataca   3166

 tctctctcca atttggcaaa aaaaaaaaaa aaaaaa                             3202




      <210> 372
      <211> 635
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (62)..(409)

      <400> 372
 tactactact aaattcgcgg ccgcgtcgac ggaaaaggtc ccggagagct gagcagtcaa     60

 g    atg tgt gac ttc acc gaa gac cag acc gca gag ttc aag gag gcc     106
      Met Cys Asp Phe Thr Glu Asp Gln Thr Ala Glu Phe Lys Glu Ala
        1               5                  10                  15

 ttc cag ctg ttt gac cga aca gag atg aat gtg aag gtg ctg gac ttt      154
 Phe Gln Leu Phe Asp Arg Thr Glu Met Asn Val Lys Val Leu Asp Phe
                  20                  25                  30

 gag cac ttt ctg ccc atg ctg cag aca gtg gcc aag aac aag gac cag      202
 Glu His Phe Leu Pro Met Leu Gln Thr Val Ala Lys Asn Lys Asp Gln
              35                  40                  45

 ggc acc tat gag gat tat gtc gaa gga ctt cgg gtg ttt gac aag gaa      250
 Gly Thr Tyr Glu Asp Tyr Val Glu Gly Leu Arg Val Phe Asp Lys Glu
          50                  55                  60

 gga aat ggc acc gtc atg ggt gct gaa atc cgg cat gtt ctt gtc aca      298
 Gly Asn Gly Thr Val Met Gly Ala Glu Ile Arg His Val Leu Val Thr
      65                  70                  75

 ctg ggt gag aag atg aca gag gaa gaa gta gag atg ctg gtg gca ggg      346
 Leu Gly Glu Lys Met Thr Glu Glu Glu Val Glu Met Leu Val Ala Gly
  80                  85                  90                  95

 cat gag gac agc aat ggt tgt atc aac tat gaa gcg ttt gtg agg cat      394
 His Glu Asp Ser Asn Gly Cys Ile Asn Tyr Glu Ala Phe Val Arg His
                 100                 105                 110

 atc ctg tcg ggg tga cgggcccatg gggcggagct cgtccgcatg gtgctgaatg      449
 Ile Leu Ser Gly 
             115

 gctgaggacc ttcccagtct ccccagagtc cgtgcctttc cctgtgtgaa ttttgtatct    509

 agcctaaagt ttccctaggc tttcttgtct cagcaacttt cccatcttgt ctctcttgga    569

 tgacgtttgc cgtcagcatt caccaaataa acttgctctc tgggccctcg gaaaaaaaaa    629

 aaaaaa                                                               635




      <210> 373
      <211> 666
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (211)..(543)

      <400> 373
 tgcagcgtct aggggtttgg cctcgaggca ggaattcggc agaggagcag agtcccatct     60

 atgcgctcct ggcctctcag caaatgctct gtcccctact cccctatctg tgcaggctga    120

 agctatgtgc atagttggga tgagggctgt gttgtctcaa caccaccctg ccctgtggtg    180

 ggtgggtgca ggtggtcgtg ggtggctgtg     atg ctc cgg ctc cca ccc aca     231
                                      Met Leu Arg Leu Pro Pro Thr
                                        1               5

 ggc acc atg cct cct gtg agg atg cag cac tcc ctg gca ggt cag acc      279
 Gly Thr Met Pro Pro Val Arg Met Gln His Ser Leu Ala Gly Gln Thr
          10                  15                  20

 tat gcc gtg ccc ctc atc cag cca gac ctg cgg cga gag gag gcc gtc      327
 Tyr Ala Val Pro Leu Ile Gln Pro Asp Leu Arg Arg Glu Glu Ala Val
      25                  30                  35

 cag cag atg gcg gat gcc ctg cag tac ctg cag aag gtc tct gga gac      375
 Gln Gln Met Ala Asp Ala Leu Gln Tyr Leu Gln Lys Val Ser Gly Asp
  40                  45                  50                  55

 atc ttc agc agg tgt tct cca gtg cca agt acc ctg ctc cag agc gcc      423
 Ile Phe Ser Arg Cys Ser Pro Val Pro Ser Thr Leu Leu Gln Ser Ala
                  60                  65                  70

 tgc agg aat atg gct cca tct tca cca gcg ccc agg acc ctg gcc tgc      471
 Cys Arg Asn Met Ala Pro Ser Ser Pro Ala Pro Arg Thr Leu Ala Cys
              75                  80                  85

 aga gac gcc ccc gcc aca gga tcc aga gca agc acc gcc ccc tgg acg      519
 Arg Asp Ala Pro Ala Thr Gly Ser Arg Ala Ser Thr Ala Pro Trp Thr
          90                  95                 100

 agc ggg ccc tgc agg aga agc tga aggactttcc tgtgtgcgtg agcaccaagc     573
 Ser Gly Pro Cys Arg Arg Ser 
     105                 110

 cggagcccga ggacgatgca gaagagggac ttgggggtct tcccagcaac atcagctctc    633

 tcagctccct gcagctcctc aacaccacct cag                                 666




      <210> 374
      <211> 1290
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (426)..(1250)

      <400> 374
 gcaggcctac tgactgctgc ctgaaggttg ctgtaaaggg actaagtaaa tcaattaact     60

 ccacagtttt cacaaaggtc tcttgatatc aaaacttctt tccttgcatg cttctctgat    120

 cctgtggaga tgaaaattga catccatagt catattctac caaaagaatg gccagatcta    180

 aaaaagcaga ccctgagaca aggattcaga tgcaagtagt ttgctttgga ggtgatccca    240

 ggaaacacca gtagagtgag gaagtgagac agggaaaaca gggcagccag tgaaagaggt    300

 ttggctacgg aggctgggtg cagctccaac accacagcaa gggagaagca aagttgttga    360

 aagatgggaa agtcttcaga gtggtgcgag agaattgctg ggatccagaa gttcgtatta    420

 gagaa    atg gac caa aaa gga gta aca gtg caa gcc ctt tcc aca gtt     467
          Met Asp Gln Lys Gly Val Thr Val Gln Ala Leu Ser Thr Val
            1               5                  10

 cct gtc atg ttt agc tac tgg gcc aaa cct gag gac act tta aac ctg      515
 Pro Val Met Phe Ser Tyr Trp Ala Lys Pro Glu Asp Thr Leu Asn Leu
  15                  20                  25                  30

 tgc cag ctt tta aac aac gac ctt gcc agc acc gtt gtg agc tac ccc      563
 Cys Gln Leu Leu Asn Asn Asp Leu Ala Ser Thr Val Val Ser Tyr Pro
                  35                  40                  45

 agg agg ttc gtg ggt ctg ggg acg ttg ccc atg cag gcc cct gag ctg      611
 Arg Arg Phe Val Gly Leu Gly Thr Leu Pro Met Gln Ala Pro Glu Leu
              50                  55                  60

 gcg gtc aag gag atg gag cgc tgt gtg aaa gag ctg ggc ttt ccc ggg      659
 Ala Val Lys Glu Met Glu Arg Cys Val Lys Glu Leu Gly Phe Pro Gly
          65                  70                  75

 gtc caa att ggc acc cac gtc aac gag tgg gac ctg aac gcg cag gag      707
 Val Gln Ile Gly Thr His Val Asn Glu Trp Asp Leu Asn Ala Gln Glu
      80                  85                  90

 ctc ttt cct gtc tat gcg gca gcc gaa agg ctg aag tgt tcc ctg ttc      755
 Leu Phe Pro Val Tyr Ala Ala Ala Glu Arg Leu Lys Cys Ser Leu Phe
  95                 100                 105                 110

 gtg cat ccc tgg gac atg cag atg gat gga cga atg gcc aaa tac tgg      803
 Val His Pro Trp Asp Met Gln Met Asp Gly Arg Met Ala Lys Tyr Trp
                 115                 120                 125

 ctc cct tgg ctt gta gga atg cca gca gag acc acc ata gcc att tgc      851
 Leu Pro Trp Leu Val Gly Met Pro Ala Glu Thr Thr Ile Ala Ile Cys
             130                 135                 140

 tcc atg atc atg ggt gga gta ttt gag aag ttt ccc aaa ctg aaa gtg      899
 Ser Met Ile Met Gly Gly Val Phe Glu Lys Phe Pro Lys Leu Lys Val
         145                 150                 155

 tgt ttc gca cat ggt ggt ggt gcc ttc ccc ttc aca gtg gga aga atc      947
 Cys Phe Ala His Gly Gly Gly Ala Phe Pro Phe Thr Val Gly Arg Ile
     160                 165                 170

 tcc cat gga ttc agc atg cgc cca gat ctg tgt gcc cag gac aac ccc      995
 Ser His Gly Phe Ser Met Arg Pro Asp Leu Cys Ala Gln Asp Asn Pro
 175                 180                 185                 190

 atg aac ccg aag aaa tac ctt ggt tcc ttt tac aca gat gct ttg gtt     1043
 Met Asn Pro Lys Lys Tyr Leu Gly Ser Phe Tyr Thr Asp Ala Leu Val
                 195                 200                 205

 cat gat cct ctg tcc ctc aag ctg tta aca gat gtc ata gga aag gat     1091
 His Asp Pro Leu Ser Leu Lys Leu Leu Thr Asp Val Ile Gly Lys Asp
             210                 215                 220

 aaa gtc att ttg gga acc gat tac ccc ttt cca cta ggt gag ctg gaa     1139
 Lys Val Ile Leu Gly Thr Asp Tyr Pro Phe Pro Leu Gly Glu Leu Glu
         225                 230                 235

 cct ggg aaa cta ata gag tcc atg gaa gaa ttt gat gaa gaa aca aag     1187
 Pro Gly Lys Leu Ile Glu Ser Met Glu Glu Phe Asp Glu Glu Thr Lys
     240                 245                 250

 aat aaa ctc aaa gcc ggc aat gcc ctg gca ttt ttg ggt ctt gag aga     1235
 Asn Lys Leu Lys Ala Gly Asn Ala Leu Ala Phe Leu Gly Leu Glu Arg
 255                 260                 265                 270

 aaa caa ttt gaa tga ctgaatttac tacaaaggca aactttcaaa aggatatctc     1290
 Lys Gln Phe Glu 






      <210> 375
      <211> 944
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (133)..(897)

      <400> 375
 gcctgatgta tataactatc tattcgatga tgaagatacc ccaccaaacc caaataaaga     60

 gatctctcga ggatccgaat tcgcggccgc gtcgacgcgg gtgctgcttg ctgcaggctc    120

 tggggagtcg cc    atg cct aca aca cag cag tcc cct cag gat gag cag     168
                  Met Pro Thr Thr Gln Gln Ser Pro Gln Asp Glu Gln
                    1               5                  10

 gaa aag ctc ttg gat gaa gcc ata cag gct gtg aag gtc cag tca ttc      216
 Glu Lys Leu Leu Asp Glu Ala Ile Gln Ala Val Lys Val Gln Ser Phe
          15                  20                  25

 caa atg aag aga tgc ctg gac aaa aac aag ctt atg gat gct cta aaa      264
 Gln Met Lys Arg Cys Leu Asp Lys Asn Lys Leu Met Asp Ala Leu Lys
      30                  35                  40

 cat gct tct aat atg ctt ggt gaa ctc cgg act tct atg tta tca cca      312
 His Ala Ser Asn Met Leu Gly Glu Leu Arg Thr Ser Met Leu Ser Pro
  45                  50                  55                  60

 aag agt tac tat gaa ctt tat atg gcc att tct gat gaa ctg cac tac      360
 Lys Ser Tyr Tyr Glu Leu Tyr Met Ala Ile Ser Asp Glu Leu His Tyr
                  65                  70                  75

 ttg gag gtc tac ctg aca gat gag ttt gct aaa gga agg aaa gtg gca      408
 Leu Glu Val Tyr Leu Thr Asp Glu Phe Ala Lys Gly Arg Lys Val Ala
              80                  85                  90

 gat ctc tac gaa ctt gta cag tat gct gga aac att atc cca agg ctt      456
 Asp Leu Tyr Glu Leu Val Gln Tyr Ala Gly Asn Ile Ile Pro Arg Leu
          95                 100                 105

 tac ctt ttg atc aca gtt gga gtt gta tat gtc aag tca ttt cct cag      504
 Tyr Leu Leu Ile Thr Val Gly Val Val Tyr Val Lys Ser Phe Pro Gln
     110                 115                 120

 tcc agg aag gat att ttg aaa gat ttg gta gaa atg tgc cgt ggt gtg      552
 Ser Arg Lys Asp Ile Leu Lys Asp Leu Val Glu Met Cys Arg Gly Val
 125                 130                 135                 140

 caa cat ccc ttg agg ggt ctg ttt ctt cga aat tac ctt ctt cag tgt      600
 Gln His Pro Leu Arg Gly Leu Phe Leu Arg Asn Tyr Leu Leu Gln Cys
                 145                 150                 155

 acc aga aat atc tta cct gat gaa gga gag cca aca gat gaa gaa aca      648
 Thr Arg Asn Ile Leu Pro Asp Glu Gly Glu Pro Thr Asp Glu Glu Thr
             160                 165                 170

 act ggt gac atc agt gat tcc atg gat ttt gta ctg ctc aac ttt gca      696
 Thr Gly Asp Ile Ser Asp Ser Met Asp Phe Val Leu Leu Asn Phe Ala
         175                 180                 185

 gaa atg aac aag ctc tgg gtg cga atg cag cat cag gga cat agc cga      744
 Glu Met Asn Lys Leu Trp Val Arg Met Gln His Gln Gly His Ser Arg
     190                 195                 200

 gat aga gaa aaa aga gaa cga gaa aga caa gaa ctg aga att tta gtg      792
 Asp Arg Glu Lys Arg Glu Arg Glu Arg Gln Glu Leu Arg Ile Leu Val
 205                 210                 215                 220

 gga aca aat ttg gtg cgc cta acc tta gtc agt tgg agg tgt aaa tgt      840
 Gly Thr Asn Leu Val Arg Leu Thr Leu Val Ser Trp Arg Cys Lys Cys
                 225                 230                 235

 gga acg tta caa aca gat tgt ttt gac tgg cat att gga gca agt tgt      888
 Gly Thr Leu Gln Thr Asp Cys Phe Asp Trp His Ile Gly Ala Ser Cys
             240                 245                 250

 aaa ctg tag ggatgct ttggctcaag aatatctcat ggagtgtatt attcaggttt      944
 Lys Leu 






      <210> 376
      <211> 1005
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (127)..(816)

      <400> 376
 gtcatttcgg agcgactcag cgcctgcccg ccctctcgcc gcgtcgccgg tgcctgcgcc     60

 tcccgctcca cctcgcttct tctctcccgg ccgaggcccg ggggaccaga gcgagaagcg    120

 gggacc   atg ttc cga cgc aag ttg acg gct ctc gac tac cac aac ccc     168
          Met Phe Arg Arg Lys Leu Thr Ala Leu Asp Tyr His Asn Pro
            1               5                  10

 gcc ggc ttc aac tgc aaa gat gaa aca gaa ttt aga aac ttc atc gtt      216
 Ala Gly Phe Asn Cys Lys Asp Glu Thr Glu Phe Arg Asn Phe Ile Val
  15                  20                  25                  30

 tgg ctt gaa gac cag aaa atc agg cac tac aag att gaa gac aga ggg      264
 Trp Leu Glu Asp Gln Lys Ile Arg His Tyr Lys Ile Glu Asp Arg Gly
                  35                  40                  45

 aat tta aga aac atc cac agc agc gac tgg ccc aag ttc ttt gaa aag      312
 Asn Leu Arg Asn Ile His Ser Ser Asp Trp Pro Lys Phe Phe Glu Lys
              50                  55                  60

 tat ctc aga gat gtt aac tgt cct ttc aag att caa gat cga caa gaa      360
 Tyr Leu Arg Asp Val Asn Cys Pro Phe Lys Ile Gln Asp Arg Gln Glu
          65                  70                  75

 gct att gac tgg ctt ctt ggt tta gct gtt aga ctt gaa tat gga gat      408
 Ala Ile Asp Trp Leu Leu Gly Leu Ala Val Arg Leu Glu Tyr Gly Asp
      80                  85                  90

 aat gct gaa aaa tac aag gat tta gta cct gat aat tca aaa act gct      456
 Asn Ala Glu Lys Tyr Lys Asp Leu Val Pro Asp Asn Ser Lys Thr Ala
  95                 100                 105                 110

 gac aat gca act aaa aat gca gaa cca ttg atc aat ttg gat gta aat      504
 Asp Asn Ala Thr Lys Asn Ala Glu Pro Leu Ile Asn Leu Asp Val Asn
                 115                 120                 125

 aat cct gat ttt aag gct ggt gtg atg gct ttg gct aac ctg ctt cag      552
 Asn Pro Asp Phe Lys Ala Gly Val Met Ala Leu Ala Asn Leu Leu Gln
             130                 135                 140

 att cag cgt cat gat gat tac ctg gta atg ctt aag gca att cgg att      600
 Ile Gln Arg His Asp Asp Tyr Leu Val Met Leu Lys Ala Ile Arg Ile
         145                 150                 155

 ttg gtt cag gag cgc ctg aca cag gat gca gtt gct aag gca aat caa      648
 Leu Val Gln Glu Arg Leu Thr Gln Asp Ala Val Ala Lys Ala Asn Gln
     160                 165                 170

 aca aaa gag gga gat gca gtt ctt aat gaa gct gct caa att ctg cga      696
 Thr Lys Glu Gly Asp Ala Val Leu Asn Glu Ala Ala Gln Ile Leu Arg
 175                 180                 185                 190

 ttg ctg cac ata gag gag ctc aga gag cta cag aca aaa atc aac gaa      744
 Leu Leu His Ile Glu Glu Leu Arg Glu Leu Gln Thr Lys Ile Asn Glu
                 195                 200                 205

 gcc ata gta gct gtt cag gca att att gct gat cca aag aca gac cac      792
 Ala Ile Val Ala Val Gln Ala Ile Ile Ala Asp Pro Lys Thr Asp His
             210                 215                 220

 aga ctg gga aaa gtt gga aga tga acacttgagg acttcagctt ctcacctact     846
 Arg Leu Gly Lys Val Gly Arg 
         225

 ttagtacagt tgggaaccat acacttctgg catgtttgga aatcaaaatg tcacattctc    906

 gggggaggaa gcccagaaaa ttgggtatgt tctagagatt taccaccatt gcttattgct    966

 tttttcttta ataaagttta ggaaagtaga aaaaaaaaa                          1005




      <210> 377
      <211> 2807
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (164)..(1390)

      <400> 377
 cttgaagagg atgatgtata taactatcta ttcgatgatg aagatacccc accaaaccca     60

 aaaaaagaga tctctcgagg atccgaattc gcggccgcgt cgacggtgag tccgggctcc    120

 cgtggccgcg tgctgggagg agactggagc ccggttagga aga  atg gag ttg gcg     175
                                                  Met Glu Leu Ala
                                                    1

 act cgc tac cag atc cct aaa gaa gtg gct gac atc ttt aac gcc ccc      223
 Thr Arg Tyr Gln Ile Pro Lys Glu Val Ala Asp Ile Phe Asn Ala Pro
   5                  10                  15                  20

 agt gat gat gaa gag ttt gtt ggc ttc cga gat gat gtt ccc atg gaa      271
 Ser Asp Asp Glu Glu Phe Val Gly Phe Arg Asp Asp Val Pro Met Glu
                  25                  30                  35

 acc ctc tcg tca gag gag agc tgc gat agt ttt gac tca cta gag tca      319
 Thr Leu Ser Ser Glu Glu Ser Cys Asp Ser Phe Asp Ser Leu Glu Ser
              40                  45                  50

 ggg aaa cag gtc gtg gag tca gat ttg agt gat gat ggc aaa gca tct      367
 Gly Lys Gln Val Val Glu Ser Asp Leu Ser Asp Asp Gly Lys Ala Ser
          55                  60                  65

 ttg gtg agc gag gaa gag gaa gat gaa gaa gaa gat aag gct acc cct      415
 Leu Val Ser Glu Glu Glu Glu Asp Glu Glu Glu Asp Lys Ala Thr Pro
      70                  75                  80

 aga aga agc agg tct aga aga agt agt att ggt ctt cga gta gcc ttt      463
 Arg Arg Ser Arg Ser Arg Arg Ser Ser Ile Gly Leu Arg Val Ala Phe
  85                  90                  95                 100

 cag ttc ccc acc aag aag ctg gcc aac aaa cca gat aaa aac agt tct      511
 Gln Phe Pro Thr Lys Lys Leu Ala Asn Lys Pro Asp Lys Asn Ser Ser
                 105                 110                 115

 tcc gag cag ttg ttt tct agc gca cgc tta cag aat gag aaa aaa aca      559
 Ser Glu Gln Leu Phe Ser Ser Ala Arg Leu Gln Asn Glu Lys Lys Thr
             120                 125                 130

 att ctt gaa aga aag aaa gac tgt aga cag gtg ata caa agg gaa gat      607
 Ile Leu Glu Arg Lys Lys Asp Cys Arg Gln Val Ile Gln Arg Glu Asp
         135                 140                 145

 tct acc tct gag tct gag gat gac tct cgg gat gag agc cag gag agt      655
 Ser Thr Ser Glu Ser Glu Asp Asp Ser Arg Asp Glu Ser Gln Glu Ser
     150                 155                 160

 tca gat gct ttg ctg aaa agg acc atg aac atc aag gag aac aaa gcc      703
 Ser Asp Ala Leu Leu Lys Arg Thr Met Asn Ile Lys Glu Asn Lys Ala
 165                 170                 175                 180

 atg ctt gcc cag tta ttg gcg gaa ttg aac tcg atg cca gat ttc ttc      751
 Met Leu Ala Gln Leu Leu Ala Glu Leu Asn Ser Met Pro Asp Phe Phe
                 185                 190                 195

 cca gta cga acc cca acc tca gct tct agg aag aag aca gtg agg cgg      799
 Pro Val Arg Thr Pro Thr Ser Ala Ser Arg Lys Lys Thr Val Arg Arg
             200                 205                 210

 gcc ttc tcg gag gga cag atc acg cgg cgt atg aac cca acc cgg agt      847
 Ala Phe Ser Glu Gly Gln Ile Thr Arg Arg Met Asn Pro Thr Arg Ser
         215                 220                 225

 gcg cgg cct cct gag aag ttt gct cta gag aac ttc act gtc tca gcc      895
 Ala Arg Pro Pro Glu Lys Phe Ala Leu Glu Asn Phe Thr Val Ser Ala
     230                 235                 240

 gct aaa ttt gcg gaa gag ttt tac agc ttc cga aga agg aag aca att      943
 Ala Lys Phe Ala Glu Glu Phe Tyr Ser Phe Arg Arg Arg Lys Thr Ile
 245                 250                 255                 260

 ggg ggg aaa tgc cgg gag tac aga cga cgt cac cgt ata tct tct ttt      991
 Gly Gly Lys Cys Arg Glu Tyr Arg Arg Arg His Arg Ile Ser Ser Phe
                 265                 270                 275

 cgg cca gtg gag gat atc acc gaa gag gac tta gaa aat gtt gcc ata     1039
 Arg Pro Val Glu Asp Ile Thr Glu Glu Asp Leu Glu Asn Val Ala Ile
             280                 285                 290

 act gtt cga gat aaa atc tat gat aaa gtt ctg ggt aac acg tgc cat     1087
 Thr Val Arg Asp Lys Ile Tyr Asp Lys Val Leu Gly Asn Thr Cys His
         295                 300                 305

 cag tgt cga caa aag acc atc gac acc aag aca gtg tgt cgg aac cag     1135
 Gln Cys Arg Gln Lys Thr Ile Asp Thr Lys Thr Val Cys Arg Asn Gln
     310                 315                 320

 ggt tgc tgt ggt gtg cga gga cag ttc tgt gga cca tgc ctg cgg aac     1183
 Gly Cys Cys Gly Val Arg Gly Gln Phe Cys Gly Pro Cys Leu Arg Asn
 325                 330                 335                 340

 cgc tat ggg gag gat gtc aga tcg gca ttg ctg gac ccg gat tgg gtg     1231
 Arg Tyr Gly Glu Asp Val Arg Ser Ala Leu Leu Asp Pro Asp Trp Val
                 345                 350                 355

 tgt ccc ccc tgt cgt ggg atc tgc aat tgc agc tac tgt cgg aag cgt     1279
 Cys Pro Pro Cys Arg Gly Ile Cys Asn Cys Ser Tyr Cys Arg Lys Arg
             360                 365                 370

 gac ggc cgc tgt gcc aca gga atc ctc att cat ctg gcc aag ttt tat     1327
 Asp Gly Arg Cys Ala Thr Gly Ile Leu Ile His Leu Ala Lys Phe Tyr
         375                 380                 385

 ggt tat gac aat gtt aag gaa tat ctg gag agc tta caa aag gag ctg     1375
 Gly Tyr Asp Asn Val Lys Glu Tyr Leu Glu Ser Leu Gln Lys Glu Leu
     390                 395                 400

 gta gaa gac aat taa gaggaaaaca aacagaacca gccacctcac catagagtac     1430
 Val Glu Asp Asn 
 405

 tccaacaaga catgcatacc attggtgcct aagatttttt tacagttgtg tttttataca   1490

 gaaattcttt gtagaaatta ctattttttg ttaaagattg tttatatgct tacaaagatt   1550

 tctcaggaag acagcagagc agaggaatct atatagatgt atgcacagac ctgtctgtat   1610

 gctgaacttt gttaaaaata tctgccagtt attaaaaagc acagtttaaa tggggtgggg   1670

 ttaaagttca ggtaagtaag ttagagagaa aacattgtat gatcagctcc tgcacttgat   1730

 ctatctttgg cttcccaaac agtaactcac tccaggccaa gtgtgcctta gcacgagtga   1790

 ccacagttta atagaccaca cacatcgttt aacctgctct tggtcattgg aaatttacac   1850

 tgaacaaagt gcaattaact gtagaacagt tttattttta ttaaaacttg actgaacaaa   1910

 aggggaccat caacattgta gacactggag gccttacaga gtgctagcct cttccttcag   1970

 gactcacctg gggcctgctg cttttatatt ttgaaagagt ttaagggcta ataatttaat   2030

 ttgttgtttg ttaaaaatta aaatctccgt tctttccggc tgcattgctt ttgcatgttc   2090

 acatatgatg tacttttatg atgtactttt ttttttttga gatggagtct tgttctgttg   2150

 cccaggaggg agtgcagtgg tgcaacctcg gctcactgca acctttgcct cctaggttca   2210

 agtgatctcc tacctcttga gtactgggat tacagtcgtg tcccacacgc tcagccctga   2270

 gttagtttct agtatttttt tctgactttc actctaagga tagcgttgaa aaaagaatgc   2330

 acgtgtgagt tactaaaaag ttagaataat gtgcatggga acagtgcagc aacatgctag   2390

 aaaatcctca ctgcactcca gcagaggcta gaggaatgcc agtgttacct tacgcttcta   2450

 gaagcagagc cactccagcc agaacccatt ttgcagtctt ctcttcgctc ttcagcctga   2510

 aggtccagat gtagctgggg cctctcagtt tggttctata cacagggcac tcgtaggtct   2570

 gtttggtttc ttgtctgtcc acgggggtgg cttttgcaaa aatgaccggc atagggcatg   2630

 ccagctcctt gagacgggct tcaacaatgg ttcctgcttg ggtgtcccag cgggcgccta   2690

 tggcaaaaac acagcggttg caattgtgtg gcagcttgct actaatgata atgatcaagt   2750

 tgtttgatgc aataaacatt caacattctg gttttgtcat aaaaaaaaaa aaaaaaa      2807




      <210> 378
      <211> 620
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (126)..(620)

      <400> 378
 atgcacgtct tggttcgggc cgggcataaa aggcttcgcg gcccagggct cacttggcgc     60

 tgagaacgcg ggtccacgcg tgtgatcgtc cgtgcgtcta gcctttgccc acgcagcttt    120

 cagtc    atg gcc tcc ggt aac gcg cgc atc gga aag cca gcc cct gac     167
          Met Ala Ser Gly Asn Ala Arg Ile Gly Lys Pro Ala Pro Asp
            1               5                  10

 ttc aag gcc aca gcg gtg gtt gat ggc gcc ttc aaa gag gtg aag ctg      215
 Phe Lys Ala Thr Ala Val Val Asp Gly Ala Phe Lys Glu Val Lys Leu
  15                  20                  25                  30

 tcg gac tac aaa ggg aag tac gtg gtc ctc ttt ttc tac cct ctg gac      263
 Ser Asp Tyr Lys Gly Lys Tyr Val Val Leu Phe Phe Tyr Pro Leu Asp
                  35                  40                  45

 ttc act ttt gtg tgc ccc acg gag atc act gca gtc agc agc cat gcc      311
 Phe Thr Phe Val Cys Pro Thr Glu Ile Thr Ala Val Ser Ser His Ala
              50                  55                  60

 gag gac ttc cgc aag ctg ggc tgc gaa gtg ctg ggc atc ttg gtg gac      359
 Glu Asp Phe Arg Lys Leu Gly Cys Glu Val Leu Gly Ile Leu Val Asp
          65                  70                  75

 tct cag ttc acc cac ctg gct tgg att aac atc ccc cgg aag gag gga      407
 Ser Gln Phe Thr His Leu Ala Trp Ile Asn Ile Pro Arg Lys Glu Gly
      80                  85                  90

 ggc ttg ggc ccc ctg aac atc ccc ctg ctt gct aat atc act gtt aat      455
 Gly Leu Gly Pro Leu Asn Ile Pro Leu Leu Ala Asn Ile Thr Val Asn
  95                 100                 105                 110

 gat ttg cct gtg gga cgc tca ttg gat gag gct ctg cag ctg gtc cag      503
 Asp Leu Pro Val Gly Arg Ser Leu Asp Glu Ala Leu Gln Leu Val Gln
                 115                 120                 125

 acc atc cag tac acg gac gag cac agg gaa gtt tgt cct gct ggc tgg      551
 Thr Ile Gln Tyr Thr Asp Glu His Arg Glu Val Cys Pro Ala Gly Trp
             130                 135                 140

 aag ctt ggc agt gac aca att aag ctc aac gtg gat gac ggc gag gaa      599
 Lys Leu Gly Ser Asp Thr Ile Lys Leu Asn Val Asp Asp Gly Glu Glu
         145                 150                 155

 tat ttc tcc aaa caa aat tag                                          620
 Tyr Phe Ser Lys Gln Asn 
     160





      <210> 379
      <211> 1521
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (236)..(1099)

      <400> 379
 cagggaagtg cctgtttatc agctgataca agatcatctc actgttttac ccaccagcat     60

 agctaaaatt gtgtatctgg atgaatgtca aacacacctt tgtcaagaga cttggagaga    120

 gggatgggcg aggtgttggg ggacacaggg gtgctctaga ccctgtgagc actgactctg    180

 cccctctctc ctcttagctg gctccagtgc ccagacccaa gccccccact gctca atg     238
                                                              Met
                                                                1

 gac acc ccc agc cca gac ccg ttg cct tcg cct ttg ccc ggg gag gaa      286
 Asp Thr Pro Ser Pro Asp Pro Leu Pro Ser Pro Leu Pro Gly Glu Glu
               5                  10                  15

 gag aaa cct ctg gcc tta tct cct cct gtt ccc cgg ggc cgc cga ggc      334
 Glu Lys Pro Leu Ala Leu Ser Pro Pro Val Pro Arg Gly Arg Arg Gly
          20                  25                  30

 cgt cgt cct ggg gga gcc acc tcc tca aat cgg aca ctc aag gcc tcc      382
 Arg Arg Pro Gly Gly Ala Thr Ser Ser Asn Arg Thr Leu Lys Ala Ser
      35                  40                  45

 ctc cct cgc aag cgg ggc cgc ccc ccc aag tca ggg cag gag ccc cca      430
 Leu Pro Arg Lys Arg Gly Arg Pro Pro Lys Ser Gly Gln Glu Pro Pro
  50                  55                  60                  65

 ctg gtg cag gtg cag ggg gtg aca gcc cca gta ggc agc agt ggc ggg      478
 Leu Val Gln Val Gln Gly Val Thr Ala Pro Val Gly Ser Ser Gly Gly
                  70                  75                  80

 agc gac ctc ctc ctg atc gat gat cag ggt gtg ccc tat acg gtc tct      526
 Ser Asp Leu Leu Leu Ile Asp Asp Gln Gly Val Pro Tyr Thr Val Ser
              85                  90                  95

 gaa ggt tca gcg gct ggg cct gag ggc tct ggc ccc agg aag gcc cca      574
 Glu Gly Ser Ala Ala Gly Pro Glu Gly Ser Gly Pro Arg Lys Ala Pro
         100                 105                 110

 cac ttc tgc ccg gtg tgc ctg cgg gcc ttc ccc tac ctc tcc gac ctg      622
 His Phe Cys Pro Val Cys Leu Arg Ala Phe Pro Tyr Leu Ser Asp Leu
     115                 120                 125

 gag cgc cac agc atc tcg cac tca gag ctg aag ccg cac cag tgc aag      670
 Glu Arg His Ser Ile Ser His Ser Glu Leu Lys Pro His Gln Cys Lys
 130                 135                 140                 145

 gtt tgc ggc aag acc ttc aag cgc tcc agc cac ctg cgg cgg cac tgc      718
 Val Cys Gly Lys Thr Phe Lys Arg Ser Ser His Leu Arg Arg His Cys
                 150                 155                 160

 aac atc cat gcc ggc ctg cgg ccc ttc cgc tgc ccg ctg tgc ccc cgc      766
 Asn Ile His Ala Gly Leu Arg Pro Phe Arg Cys Pro Leu Cys Pro Arg
             165                 170                 175

 cgc ttc cgc gag gcg ggc gag ctg gcg cac cac cat cgc gtg cac tcg      814
 Arg Phe Arg Glu Ala Gly Glu Leu Ala His His His Arg Val His Ser
         180                 185                 190

 ggg gag cgc ccg tac cag tgc ccc atc tgc cgg ctg cgc ttt aca gag      862
 Gly Glu Arg Pro Tyr Gln Cys Pro Ile Cys Arg Leu Arg Phe Thr Glu
     195                 200                 205

 gcc aac acg ctc cgg cgc cat gcg aag cgc aag cac ccg gag gcc atg      910
 Ala Asn Thr Leu Arg Arg His Ala Lys Arg Lys His Pro Glu Ala Met
 210                 215                 220                 225

 ggg gta ccc ctg tgt gca cca gat cca ggg tct gaa ccg ccg tgg gac      958
 Gly Val Pro Leu Cys Ala Pro Asp Pro Gly Ser Glu Pro Pro Trp Asp
                 230                 235                 240

 gag gag ggc att ccg gcc aca gca ggg gcc gag gag ccg gtt gac aca     1006
 Glu Glu Gly Ile Pro Ala Thr Ala Gly Ala Glu Glu Pro Val Asp Thr
             245                 250                 255

 ctt tgg aaa ggg gag ccc gct ccg gcg cca tgc caa gcg caa gca ccc     1054
 Leu Trp Lys Gly Glu Pro Ala Pro Ala Pro Cys Gln Ala Gln Ala Pro
         260                 265                 270

 gga ggc cat ggg ggt acc cct gtg tgc acc aga tcc agg gtc tga acc     1102
 Gly Gly His Gly Gly Thr Pro Val Cys Thr Arg Ser Arg Val 
     275                 280                 285

 gccgtgggac gaggagggca tcccggccac agcaggggcc gaggaagagg aggagacaga   1162

 ggggaaaggg gagccggcct gacccacacc cccggccatc gctccctggg ccaggtttag   1222

 agcagggagt ttggctggtg ctgggcctga gccagggggc cgggacaccc ttgtttccgg   1282

 tggtcttccc gttgtgggag caggtggagg gtggagacct aaactttggg gtccagctgc   1342

 cttcagcccc cctcccccag actaacagac ccttggaggc aggggctgtg gaaataaatc   1402

 tctgcctgct ggctgcctgt gtgtgttccg tgccgggatg ccatcctctc ctgccttcaa   1462

 atgttcttcc tcggctacac cgtcctgtcg ggagtgcggg gaattgggga ggaccccac    1521




      <210> 380
      <211> 2013
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (478)..(1800)

      <400> 380
 aaaacagtgg ctttattggg atgtaactcc atcattagtc aaggagcatc tgtgtatatc     60

 ttttgatacc acactatggt atttgatcct caccacgacc agttaagtgg gtagtataat    120

 cttcatttta tagggaaagg tagcaaggcc cagggaagtt ggttttgtga catgttctta    180

 agtggcagag ctgggtcttg agcccagatc ttctggtttc gttagtcatg ccctttaagc    240

 tccttgagaa cagagagaac agtttttcac agagtgtttt ctcaattatg tggctcacat    300

 tgaacatatc tcaaatcagg aagatatatc ttcacataga aatatatggg atcatttgtt    360

 tttctttcag aaaagctgtc attgaatcag ttgtagtgcc tctgaaatca ctgttgtaga    420

 atcaaggaaa tatatagatc tctctccagt gcctaataga gcctttatac ataatat       477                                                                 
 atg cct ggt aaa tgt ttg tat gcg cgg ctg cga gag gcg gcg gca cga      525
 Met Pro Gly Lys Cys Leu Tyr Ala Arg Leu Arg Glu Ala Ala Ala Arg
   1               5                  10                  15

 cga cgg tcc ctc agc cca gcc acc atg agc acc aag cag atc act tgc      573
 Arg Arg Ser Leu Ser Pro Ala Thr Met Ser Thr Lys Gln Ile Thr Cys
              20                  25                  30

 agg tat ttt atg cat ggt gtg tgt cgg gaa gga agt cag tgc cta ttc      621
 Arg Tyr Phe Met His Gly Val Cys Arg Glu Gly Ser Gln Cys Leu Phe
          35                  40                  45

 tca cat gac ttg gca aac agc aaa ccg tcc acc atc tgc aag tac tac      669
 Ser His Asp Leu Ala Asn Ser Lys Pro Ser Thr Ile Cys Lys Tyr Tyr
      50                  55                  60

 cag aag ggc tac tgt gcc tat gga act cgg tgc aga tat gac cac acg      717
 Gln Lys Gly Tyr Cys Ala Tyr Gly Thr Arg Cys Arg Tyr Asp His Thr
  65                  70                  75                  80

 agg ccc tct gct gca gct gga ggt gct gtg ggc acc atg gcc cac agt      765
 Arg Pro Ser Ala Ala Ala Gly Gly Ala Val Gly Thr Met Ala His Ser
                  85                  90                  95

 gtg ccc tcc cca gct ttc cac agt cct cac cct cct tcc gag gtc act      813
 Val Pro Ser Pro Ala Phe His Ser Pro His Pro Pro Ser Glu Val Thr
             100                 105                 110

 gca tcc att gtg aaa act aac tca cat gaa ccc gga aag cgt gaa aag      861
 Ala Ser Ile Val Lys Thr Asn Ser His Glu Pro Gly Lys Arg Glu Lys
         115                 120                 125

 aga aca ttg gtt ctt aga gac cga aat ctc tct ggc atg gct gaa agg      909
 Arg Thr Leu Val Leu Arg Asp Arg Asn Leu Ser Gly Met Ala Glu Arg
     130                 135                 140

 aag acc cag ccg agc atg gtg agt aat cca ggc agc tgc agc gac ccc      957
 Lys Thr Gln Pro Ser Met Val Ser Asn Pro Gly Ser Cys Ser Asp Pro
 145                 150                 155                 160

 cag ccc agc ccc gag atg aag ccg cat tcc tac ctg gat gcc atc agg     1005
 Gln Pro Ser Pro Glu Met Lys Pro His Ser Tyr Leu Asp Ala Ile Arg
                 165                 170                 175

 agt ggc ctt gat gac gtg gag gcc agc agc tcc tac agc aac gag cag     1053
 Ser Gly Leu Asp Asp Val Glu Ala Ser Ser Ser Tyr Ser Asn Glu Gln
             180                 185                 190

 cag ctg tgc ccc tac gca gct gct ggg gag tgc cgg ttt ggg gat gcc     1101
 Gln Leu Cys Pro Tyr Ala Ala Ala Gly Glu Cys Arg Phe Gly Asp Ala
         195                 200                 205

 tgt gtc tac ctg cac ggg gag gtg tgt gaa atc tgt agg ctg caa gtc     1149
 Cys Val Tyr Leu His Gly Glu Val Cys Glu Ile Cys Arg Leu Gln Val
     210                 215                 220

 ttg cac cca ttc gac cca gag cag agg aag gct cac gaa aag atc tgc     1197
 Leu His Pro Phe Asp Pro Glu Gln Arg Lys Ala His Glu Lys Ile Cys
 225                 230                 235                 240

 atg ttg acg ttc gaa cac gag atg gaa aag gcc ttt gcc ttc cag gca     1245
 Met Leu Thr Phe Glu His Glu Met Glu Lys Ala Phe Ala Phe Gln Ala
                 245                 250                 255

 agc cag gac aaa gtg tgc agt atc tgc atg gaa gtg atc ctg gag aag     1293
 Ser Gln Asp Lys Val Cys Ser Ile Cys Met Glu Val Ile Leu Glu Lys
             260                 265                 270

 gcc tct gct tct gag agg aga ttt ggg att ctc tcc aat tgc aat cac     1341
 Ala Ser Ala Ser Glu Arg Arg Phe Gly Ile Leu Ser Asn Cys Asn His
         275                 280                 285

 acg tac tgt ttg tcc tgc atc cgg cag tgg cgg tgt gcc aaa cag ttt     1389
 Thr Tyr Cys Leu Ser Cys Ile Arg Gln Trp Arg Cys Ala Lys Gln Phe
     290                 295                 300

 gaa aac cca atc att aag tct tgt cca gaa tgc cgt gtg ata tca gag     1437
 Glu Asn Pro Ile Ile Lys Ser Cys Pro Glu Cys Arg Val Ile Ser Glu
 305                 310                 315                 320

 ttt gta att cca agt gtg tat tgg gtg gaa gat cag aat aaa aag aac     1485
 Phe Val Ile Pro Ser Val Tyr Trp Val Glu Asp Gln Asn Lys Lys Asn
                 325                 330                 335

 gag ttg att gaa gct ttc aaa cag ggg atg ggg aaa aaa gcc tgt aaa     1533
 Glu Leu Ile Glu Ala Phe Lys Gln Gly Met Gly Lys Lys Ala Cys Lys
             340                 345                 350

 tac ttt gag caa ggc aag ggg acc tgc cca ttt gga agc aaa tgt ctt     1581
 Tyr Phe Glu Gln Gly Lys Gly Thr Cys Pro Phe Gly Ser Lys Cys Leu
         355                 360                 365

 tat cgc cat gct tac ccc gat ggg cgg cta gca gag cct gag aaa cct     1629
 Tyr Arg His Ala Tyr Pro Asp Gly Arg Leu Ala Glu Pro Glu Lys Pro
     370                 375                 380

 cgg aaa cag ctc agt tct caa ggc act gtg agg ttc ttt aat tca gtg     1677
 Arg Lys Gln Leu Ser Ser Gln Gly Thr Val Arg Phe Phe Asn Ser Val
 385                 390                 395                 400

 cgg ctc tgg gat ttc atc gag aac cga gaa agc cgg cat gtc ccc aac     1725
 Arg Leu Trp Asp Phe Ile Glu Asn Arg Glu Ser Arg His Val Pro Asn
                 405                 410                 415

 aat gaa gat gtc gac atg aca gag ctc ggg gac ctc ttc atg cac ctt     1773
 Asn Glu Asp Val Asp Met Thr Glu Leu Gly Asp Leu Phe Met His Leu
             420                 425                 430

 tct gga gtg gaa tca tca gaa ccc taa agagt agatggttgc cctgcatctt     1825
 Ser Gly Val Glu Ser Ser Glu Pro 
         435                 440

 gggctccatc ggccgaaact ttcccaagcc agggtgtgcg gagcttccct gtactgcagc   1885

 caaggtgacg tgtgacttgg atttgagtgg agttgggctt agccttagtc tcattcaatc   1945

 tccattatta cagccatggg gaagagtgaa agatataaag taacctaatt aaatgtaaaa   2005

 aaaaaaaa                                                            2013




      <210> 381
      <211> 5468
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (221)..(4690)

      <400> 381
 agccgacacc ctttacagtc aaattaaaga agatgtcaaa aagcgtgctg tggcactgga     60

 tgaagccatt tctcaatcaa ctcagttcca tgacaagata gatcagatcc ttgagagcct    120

 ggaacgcatc gtggaacgtc tgaggcagcc accctctatc tctgcagagg ttgagaagat    180

 caaggaacag atcagtgaaa ataagaatgt gtcagtagac  atg gaa aag cta cag     235
                                              Met Glu Lys Leu Gln
                                                1               5

 ccg ttg tat gaa act ctt aaa cag agg gga gag gaa atg att gct aga      283
 Pro Leu Tyr Glu Thr Leu Lys Gln Arg Gly Glu Glu Met Ile Ala Arg
                  10                  15                  20

 tct ggg ggg act gat aaa gac ata tct gcc aaa gct gtt cag gat aag      331
 Ser Gly Gly Thr Asp Lys Asp Ile Ser Ala Lys Ala Val Gln Asp Lys
              25                  30                  35

 ctt gac caa atg gtt ttc att tgg gag aac ata cac aca ctg gtg gaa      379
 Leu Asp Gln Met Val Phe Ile Trp Glu Asn Ile His Thr Leu Val Glu
          40                  45                  50

 gag agg gaa gcc aaa cta ctg gat gtg atg gag cta gca gaa aag ttc      427
 Glu Arg Glu Ala Lys Leu Leu Asp Val Met Glu Leu Ala Glu Lys Phe
      55                  60                  65

 tgg tgt gat cac atg tca ttg ata gtt acc att aaa gat act caa gat      475
 Trp Cys Asp His Met Ser Leu Ile Val Thr Ile Lys Asp Thr Gln Asp
  70                  75                  80                  85

 ttc atc cgg gac ctg gaa gat cct gga att gat cct tca gta gta aaa      523
 Phe Ile Arg Asp Leu Glu Asp Pro Gly Ile Asp Pro Ser Val Val Lys
                  90                  95                 100

 caa cag caa gaa gca gca gag acc ata agg gaa gaa ata gat gga cta      571
 Gln Gln Gln Glu Ala Ala Glu Thr Ile Arg Glu Glu Ile Asp Gly Leu
             105                 110                 115

 cag gag gag ctg gat ata gtt att aac cta ggt tct gaa ctc att gcg      619
 Gln Glu Glu Leu Asp Ile Val Ile Asn Leu Gly Ser Glu Leu Ile Ala
         120                 125                 130

 gca tgt ggg gag cct gat aaa ccc att gtc aag aag agt ata gat gag      667
 Ala Cys Gly Glu Pro Asp Lys Pro Ile Val Lys Lys Ser Ile Asp Glu
     135                 140                 145

 tta aat tca gca tgg gat tct cta aat aaa gct tgg aaa gac cgg att      715
 Leu Asn Ser Ala Trp Asp Ser Leu Asn Lys Ala Trp Lys Asp Arg Ile
 150                 155                 160                 165

 gac aaa ctt gag gag gca atg cag gct gcc gtt cag tac cag gat gga      763
 Asp Lys Leu Glu Glu Ala Met Gln Ala Ala Val Gln Tyr Gln Asp Gly
                 170                 175                 180

 ctg cag gcg gta ttt gac tgg gta gat att gca ggt ggt aaa tta gct      811
 Leu Gln Ala Val Phe Asp Trp Val Asp Ile Ala Gly Gly Lys Leu Ala
             185                 190                 195

 tca atg tct cca att gga aca gat ctc gaa act gtc aag cag cag att      859
 Ser Met Ser Pro Ile Gly Thr Asp Leu Glu Thr Val Lys Gln Gln Ile
         200                 205                 210

 gaa gag cta aag caa ttt aag tct gag gcc tat caa cag cag ata gaa      907
 Glu Glu Leu Lys Gln Phe Lys Ser Glu Ala Tyr Gln Gln Gln Ile Glu
     215                 220                 225

 atg gaa aga ctg aat cat caa gca gag ctt ttg cta aag aaa gta aca      955
 Met Glu Arg Leu Asn His Gln Ala Glu Leu Leu Leu Lys Lys Val Thr
 230                 235                 240                 245

 gaa gag agt gac aaa cac act gtt caa gac cca tta atg gaa ctg aaa     1003
 Glu Glu Ser Asp Lys His Thr Val Gln Asp Pro Leu Met Glu Leu Lys
                 250                 255                 260

 ttg ata tgg gat agc ctg gag gag aga atc atc aac aga cag cat aaa     1051
 Leu Ile Trp Asp Ser Leu Glu Glu Arg Ile Ile Asn Arg Gln His Lys
             265                 270                 275

 ctg gag ggt gct cta tta gcc ttg ggt cag ttc caa cat gcc ctg gat     1099
 Leu Glu Gly Ala Leu Leu Ala Leu Gly Gln Phe Gln His Ala Leu Asp
         280                 285                 290

 gag ctc ctg gca tgg ctg aca cac acc gag ggc ttg cta agt gag cag     1147
 Glu Leu Leu Ala Trp Leu Thr His Thr Glu Gly Leu Leu Ser Glu Gln
     295                 300                 305

 aaa cct gtt gga gga gac cct aaa gcc att gaa att gaa ctt gcc aag     1195
 Lys Pro Val Gly Gly Asp Pro Lys Ala Ile Glu Ile Glu Leu Ala Lys
 310                 315                 320                 325

 cat cat gtg ctc caa aat gat gta tta gcc cat cag tcc aca gtg gaa     1243
 His His Val Leu Gln Asn Asp Val Leu Ala His Gln Ser Thr Val Glu
                 330                 335                 340

 gcc gtt aat aaa gca gga aat gat cta att gaa tca agt gca gga gaa     1291
 Ala Val Asn Lys Ala Gly Asn Asp Leu Ile Glu Ser Ser Ala Gly Glu
             345                 350                 355

 gaa gca agc aac ctt cag aac aag cta gag gtt tta aat caa cgc tgg     1339
 Glu Ala Ser Asn Leu Gln Asn Lys Leu Glu Val Leu Asn Gln Arg Trp
         360                 365                 370

 caa aat gtt ttg gaa aaa aca gaa caa agg aag cag cag ctg gat ggt     1387
 Gln Asn Val Leu Glu Lys Thr Glu Gln Arg Lys Gln Gln Leu Asp Gly
     375                 380                 385

 gcc ttg cgc cag gcc aaa ggg ttc cat ggc gaa att gag gat ttg cag     1435
 Ala Leu Arg Gln Ala Lys Gly Phe His Gly Glu Ile Glu Asp Leu Gln
 390                 395                 400                 405

 cag tgg ctg act gac acg gag cgt cat ctg ttg gca tct aaa ccg ctg     1483
 Gln Trp Leu Thr Asp Thr Glu Arg His Leu Leu Ala Ser Lys Pro Leu
                 410                 415                 420

 gga ggt tta ccg gaa aca gcc aag gag cag ctt aat gtc cat atg gaa     1531
 Gly Gly Leu Pro Glu Thr Ala Lys Glu Gln Leu Asn Val His Met Glu
             425                 430                 435

 gtc tgt gct gcc ttt gaa gct aaa gaa gaa aca tat aag agt ctg atg     1579
 Val Cys Ala Ala Phe Glu Ala Lys Glu Glu Thr Tyr Lys Ser Leu Met
         440                 445                 450

 cag aaa ggc cag cag atg ctt gca aga tgc cca aaa tct gca gag aca     1627
 Gln Lys Gly Gln Gln Met Leu Ala Arg Cys Pro Lys Ser Ala Glu Thr
     455                 460                 465

 aat att gac caa gac ata aat aac ttg aaa aaa aaa tgg gaa tcg gtg     1675
 Asn Ile Asp Gln Asp Ile Asn Asn Leu Lys Lys Lys Trp Glu Ser Val
 470                 475                 480                 485

 gaa acc aaa ctc aat gaa agg aaa act aaa ctg gaa gag gct ctc aac     1723
 Glu Thr Lys Leu Asn Glu Arg Lys Thr Lys Leu Glu Glu Ala Leu Asn
                 490                 495                 500

 ttg gca atg gag ttc cac aat tct ctc caa gac ttc atc aac tgg ctt     1771
 Leu Ala Met Glu Phe His Asn Ser Leu Gln Asp Phe Ile Asn Trp Leu
             505                 510                 515

 act cag gct gaa cag acc cta aat gta gct tct cgg cca agt ctc atc     1819
 Thr Gln Ala Glu Gln Thr Leu Asn Val Ala Ser Arg Pro Ser Leu Ile
         520                 525                 530

 ttg gac aca gtc tta ttt caa att gac gaa cac aag gtt ttt gcc aat     1867
 Leu Asp Thr Val Leu Phe Gln Ile Asp Glu His Lys Val Phe Ala Asn
     535                 540                 545

 gaa gta aat tct cat cgt gag cag ata ata gag ctg gac aaa act gga     1915
 Glu Val Asn Ser His Arg Glu Gln Ile Ile Glu Leu Asp Lys Thr Gly
 550                 555                 560                 565

 acc cac cta aaa tat ttt agt cag aaa caa gat gtt gtt cta atc aag     1963
 Thr His Leu Lys Tyr Phe Ser Gln Lys Gln Asp Val Val Leu Ile Lys
                 570                 575                 580

 aat cta ctt atc agt gta caa agt cga tgg gaa aaa gtg gtt caa cgg     2011
 Asn Leu Leu Ile Ser Val Gln Ser Arg Trp Glu Lys Val Val Gln Arg
             585                 590                 595

 ttg gta gag aga gga aga tct ttg gat gat gca agg aag aga gcc aag     2059
 Leu Val Glu Arg Gly Arg Ser Leu Asp Asp Ala Arg Lys Arg Ala Lys
         600                 605                 610

 cag ttc cat gaa gct tgg agt aaa ctt atg gag tgg cta gaa gag tca     2107
 Gln Phe His Glu Ala Trp Ser Lys Leu Met Glu Trp Leu Glu Glu Ser
     615                 620                 625

 gaa aag tct ttg gat tct gaa ctg gaa atc gca aat gat cca gac aaa     2155
 Glu Lys Ser Leu Asp Ser Glu Leu Glu Ile Ala Asn Asp Pro Asp Lys
 630                 635                 640                 645

 ata aaa aca caa ctt gca caa cat aag gag ttt cag aaa tca ctc gga     2203
 Ile Lys Thr Gln Leu Ala Gln His Lys Glu Phe Gln Lys Ser Leu Gly
                 650                 655                 660

 gcc aag cat tct gtc tac gac acc acc aac agg act gga cgt tct ctg     2251
 Ala Lys His Ser Val Tyr Asp Thr Thr Asn Arg Thr Gly Arg Ser Leu
             665                 670                 675

 aag gag aaa acc tcc ctg gct gat gac aac ctg aaa ctg gat gac atg     2299
 Lys Glu Lys Thr Ser Leu Ala Asp Asp Asn Leu Lys Leu Asp Asp Met
         680                 685                 690

 ctg agt gaa ctc aga gac aaa tgg gat acc ata tgt gga aaa tct gtg     2347
 Leu Ser Glu Leu Arg Asp Lys Trp Asp Thr Ile Cys Gly Lys Ser Val
     695                 700                 705

 gaa aga caa aac aaa ttg gag gaa gcc ctg tta ttt tct gga caa ttc     2395
 Glu Arg Gln Asn Lys Leu Glu Glu Ala Leu Leu Phe Ser Gly Gln Phe
 710                 715                 720                 725

 aca gat gcc cta cag gct ctc att gat tgg tta tat aga gtt gaa ccc     2443
 Thr Asp Ala Leu Gln Ala Leu Ile Asp Trp Leu Tyr Arg Val Glu Pro
                 730                 735                 740

 cag ctg gca gaa gac cag cct gtt cat gga gac att gat ttg gtg atg     2491
 Gln Leu Ala Glu Asp Gln Pro Val His Gly Asp Ile Asp Leu Val Met
             745                 750                 755

 aat ctg atc gat aat cac aag gcc ttc caa aaa gag ttg ggg aag agg     2539
 Asn Leu Ile Asp Asn His Lys Ala Phe Gln Lys Glu Leu Gly Lys Arg
         760                 765                 770

 acc agc agt gtg cag gcc ctg aag cgc tca gcc cga gaa ctc ata gaa     2587
 Thr Ser Ser Val Gln Ala Leu Lys Arg Ser Ala Arg Glu Leu Ile Glu
     775                 780                 785

 ggc agt cgg gat gac tcc tcc tgg gtc aag gtc cag atg cag gaa tta     2635
 Gly Ser Arg Asp Asp Ser Ser Trp Val Lys Val Gln Met Gln Glu Leu
 790                 795                 800                 805

 agc aca cgc tgg gag acc gtg tgt gca ctt tct ata tca aag caa aca     2683
 Ser Thr Arg Trp Glu Thr Val Cys Ala Leu Ser Ile Ser Lys Gln Thr
                 810                 815                 820

 cgg tta gaa gca gcc ctg cgt cag gca gag gaa ttc cac tcg gtg gta     2731
 Arg Leu Glu Ala Ala Leu Arg Gln Ala Glu Glu Phe His Ser Val Val
             825                 830                 835

 cat gcc ctc ttg gag tgg ctg gct gag gcg gag caa acc ctg cgt ttc     2779
 His Ala Leu Leu Glu Trp Leu Ala Glu Ala Glu Gln Thr Leu Arg Phe
         840                 845                 850

 cat ggt gtc ctc cca gat gat gag gat gct ctc cgg act ctc att gat     2827
 His Gly Val Leu Pro Asp Asp Glu Asp Ala Leu Arg Thr Leu Ile Asp
     855                 860                 865

 cag cat aaa gaa ttc atg aag aaa ctg gaa gaa aag aga gct gaa cta     2875
 Gln His Lys Glu Phe Met Lys Lys Leu Glu Glu Lys Arg Ala Glu Leu
 870                 875                 880                 885

 aat aaa gcc acc act atg ggc gac acc gtt ttg gct atc tgc cac ccc     2923
 Asn Lys Ala Thr Thr Met Gly Asp Thr Val Leu Ala Ile Cys His Pro
                 890                 895                 900

 gac tcc atc act acc att aag cac tgg ata aca atc atc cgg gcg agg     2971
 Asp Ser Ile Thr Thr Ile Lys His Trp Ile Thr Ile Ile Arg Ala Arg
             905                 910                 915

 ttt gag gag gtg ctg gcc tgg gca aag caa cat cag cag aga tta gca     3019
 Phe Glu Glu Val Leu Ala Trp Ala Lys Gln His Gln Gln Arg Leu Ala
         920                 925                 930

 agt gct ctg gct ggg ctt att gcc aaa cag gaa ttg ttg gaa gct ttg     3067
 Ser Ala Leu Ala Gly Leu Ile Ala Lys Gln Glu Leu Leu Glu Ala Leu
     935                 940                 945

 ctg gct tgg ttg caa tgg gct gaa act aca ctt act gat aag gat aaa     3115
 Leu Ala Trp Leu Gln Trp Ala Glu Thr Thr Leu Thr Asp Lys Asp Lys
 950                 955                 960                 965

 gaa gtc atc ccc cag gag atc gaa gag gtg aaa gca ctc att gca gaa     3163
 Glu Val Ile Pro Gln Glu Ile Glu Glu Val Lys Ala Leu Ile Ala Glu
                 970                 975                 980

 cac cag acc ttc atg gag gaa atg acc aga aaa cag cct gat gtt gat     3211
 His Gln Thr Phe Met Glu Glu Met Thr Arg Lys Gln Pro Asp Val Asp
             985                 990                 995

 aaa gta acg aag acc tat aag agg aga gct gct gat cct tcc tca tta     3259
 Lys Val Thr Lys Thr Tyr Lys Arg Arg Ala Ala Asp Pro Ser Ser Leu
        1000                1005                1010

 caa tcc cat att cca gtc ttg gat aag gga cga gca gga aga aaa cgc     3307
 Gln Ser His Ile Pro Val Leu Asp Lys Gly Arg Ala Gly Arg Lys Arg
    1015                1020                1025

 ttt cca gca tca agc ttg tat ccc tct ggg tca cag aca caa att gaa     3355
 Phe Pro Ala Ser Ser Leu Tyr Pro Ser Gly Ser Gln Thr Gln Ile Glu
1030                1035                1040                1045

 acc aaa aat cct agg gta aac tta ctg gtg agc aaa tgg cag caa gtc     3403
 Thr Lys Asn Pro Arg Val Asn Leu Leu Val Ser Lys Trp Gln Gln Val
                1050                1055                1060

 tgg ctc ctg gcg ttg gaa aga agg agg aaa ctc aat gat gcc ttg gac     3451
 Trp Leu Leu Ala Leu Glu Arg Arg Arg Lys Leu Asn Asp Ala Leu Asp
            1065                1070                1075

 aga cta gag gag ctg agg gaa ttt gct aac ttt gat ttt gat atc tgg     3499
 Arg Leu Glu Glu Leu Arg Glu Phe Ala Asn Phe Asp Phe Asp Ile Trp
        1080                1085                1090

 cgc aaa aaa tac atg cga tgg atg aat cac aag aaa tct cga gtg atg     3547
 Arg Lys Lys Tyr Met Arg Trp Met Asn His Lys Lys Ser Arg Val Met
    1095                1100                1105

 gac ttc ttc agg aga att gat aaa gac cag gat ggg aaa ata acg cgg     3595
 Asp Phe Phe Arg Arg Ile Asp Lys Asp Gln Asp Gly Lys Ile Thr Arg
1110                1115                1120                1125

 cag gaa ttt att gat gga att ctt tcc tca aag ttt cca acc agt cgc     3643
 Gln Glu Phe Ile Asp Gly Ile Leu Ser Ser Lys Phe Pro Thr Ser Arg
                1130                1135                1140

 ttg gag atg agc gca gtt gca gac atc ttt gac aga gat ggc gat gga     3691
 Leu Glu Met Ser Ala Val Ala Asp Ile Phe Asp Arg Asp Gly Asp Gly
            1145                1150                1155

 tat att gac tac tat gaa ttt gta gca gcc ctt cac cca aat aaa gat     3739
 Tyr Ile Asp Tyr Tyr Glu Phe Val Ala Ala Leu His Pro Asn Lys Asp
        1160                1165                1170

 gca tat aaa cct atc aca gat gcc gac aaa atc gaa gat gag gtg aca     3787
 Ala Tyr Lys Pro Ile Thr Asp Ala Asp Lys Ile Glu Asp Glu Val Thr
    1175                1180                1185

 agg cag gta gct aag tgt aaa tgt gca aag cga ttt caa gtt gag cag     3835
 Arg Gln Val Ala Lys Cys Lys Cys Ala Lys Arg Phe Gln Val Glu Gln
1190                1195                1200                1205

 att ggt gat aat aaa tac agg ttc ttc ctg gga aat cag ttt gga gac     3883
 Ile Gly Asp Asn Lys Tyr Arg Phe Phe Leu Gly Asn Gln Phe Gly Asp
                1210                1215                1220

 tcc cag caa ctg cga ctg gtc cgg atc ctg cgg agt act gtg atg gtt     3931
 Ser Gln Gln Leu Arg Leu Val Arg Ile Leu Arg Ser Thr Val Met Val
            1225                1230                1235

 cgt gtt gga ggt gga tgg atg gca ctt gat gag ttc tta gtg aaa aat     3979
 Arg Val Gly Gly Gly Trp Met Ala Leu Asp Glu Phe Leu Val Lys Asn
        1240                1245                1250

 gat cct tgc agg gcc aaa gga agg aca aac atg gaa ctg cgt gag aag     4027
 Asp Pro Cys Arg Ala Lys Gly Arg Thr Asn Met Glu Leu Arg Glu Lys
    1255                1260                1265

 ttc att tta gca gat ggt gcc agc cag ggt atg gct gct ttc cga ccc     4075
 Phe Ile Leu Ala Asp Gly Ala Ser Gln Gly Met Ala Ala Phe Arg Pro
1270                1275                1280                1285

 cga ggc cga aga tcc cgg cca tca tca cga ggc gct tca ccc aac aga     4123
 Arg Gly Arg Arg Ser Arg Pro Ser Ser Arg Gly Ala Ser Pro Asn Arg
                1290                1295                1300

 tcc act tct gtg tcc agt cag gct gcg cag gcg gcc tcc cca cag gtc     4171
 Ser Thr Ser Val Ser Ser Gln Ala Ala Gln Ala Ala Ser Pro Gln Val
            1305                1310                1315

 cct gcc acc acc aca ccc aag att ctc cat cct tta aca cgc aat tat     4219
 Pro Ala Thr Thr Thr Pro Lys Ile Leu His Pro Leu Thr Arg Asn Tyr
        1320                1325                1330

 ggt aaa cca tgg ttg aca aac agc aaa atg tca act cct tgt aaa gca     4267
 Gly Lys Pro Trp Leu Thr Asn Ser Lys Met Ser Thr Pro Cys Lys Ala
    1335                1340                1345

 gca gag tgc tca gac ttt ccc gtg cca tct gca gag gga acg cca ata     4315
 Ala Glu Cys Ser Asp Phe Pro Val Pro Ser Ala Glu Gly Thr Pro Ile
1350                1355                1360                1365

 caa gga agc aag ctt cga ctt cca gga tat tta tca ggg aaa ggc ttc     4363
 Gln Gly Ser Lys Leu Arg Leu Pro Gly Tyr Leu Ser Gly Lys Gly Phe
                1370                1375                1380

 cac tct ggg gag gac agt ggc ttg ata aca act gca gct gcc aga gtc     4411
 His Ser Gly Glu Asp Ser Gly Leu Ile Thr Thr Ala Ala Ala Arg Val
            1385                1390                1395

 cga aca cag ttt gct gat tcc aag aag act ccc agc cga cca gga agt     4459
 Arg Thr Gln Phe Ala Asp Ser Lys Lys Thr Pro Ser Arg Pro Gly Ser
        1400                1405                1410

 cga gct gga agc aaa gct ggc agc agg gcc agc agc cgc cga ggc agt     4507
 Arg Ala Gly Ser Lys Ala Gly Ser Arg Ala Ser Ser Arg Arg Gly Ser
    1415                1420                1425

 gat gca tca gac ttt gac att tca gaa atc cag tcc gtg tgc tca gat     4555
 Asp Ala Ser Asp Phe Asp Ile Ser Glu Ile Gln Ser Val Cys Ser Asp
1430                1435                1440                1445

 gtg gaa act gtc ccc cag aca cac aga cct aca ccc cga gca ggt tct     4603
 Val Glu Thr Val Pro Gln Thr His Arg Pro Thr Pro Arg Ala Gly Ser
                1450                1455                1460

 cgg cca tcc aca gcg aag cct tca aaa atc ccc acg ccc cag agg aaa     4651
 Arg Pro Ser Thr Ala Lys Pro Ser Lys Ile Pro Thr Pro Gln Arg Lys
            1465                1470                1475

 tca cct gcc agc aaa ttg gac aag tcc tca aag aga tag tgcaattggt      4700
 Ser Pro Ala Ser Lys Leu Asp Lys Ser Ser Lys Arg 
        1480                1485

 tctaccaagg cccttccttg agcatttatt atttaagttt gaacgatgta aaatatggtg   4760

 tagaaattct tgtgaaatat tgcaagaggc gagtttaaaa ttctgcagat ggccttattt   4820

 gtgtatttgt ctttttattt tatctgtata attttttttg tcagatattc tggggttaaa   4880

 gtcacatcat atgtgaggag gaaaagttta acatgaacta acatttctgc actgtaacgt   4940

 gccgggcaca cactaaactc agttactgta cctacaggta agtctacatc ctctctgaca   5000

 gccacagcac tacatcaatc cctgacgtta gggatacctc atgacatttt cctgttttta   5060

 tggaaactct gagaagctga atgatacatg caggggatat tttttgagat gatttaaatg   5120

 taaaccaaaa gatggaagac aaaaagacaa acacacccac acgcagtctt tgcagtatct   5180

 gacagagaac tcacaggaag ttacttcaag cacttgccag tactatgata ttcaagtacc   5240

 ttgcagcatt tctctgccat tgctttcaat gaggccagag gcatcctgga tattagacct   5300

 attatactgt aagaatataa gtataaagtg cgttcatata catgtgaggt tttcttttgc   5360

 ttgagtggac agtagcacct gtatcattga actcattttg tatcagagca attttgcttg   5420

 cagaaagcta tgaaataaaa cacgtccctt aactgcaaaa aaaaaaaa                5468




      <210> 382
      <211> 3000
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (86)..(2008)

      <400> 382
 tatagctgtc gcgcacgacg taccgggccg gaaatttcgt agcagagccc tgtccacagc     60

 aaacgaaaat gatggctacg tggtc  atg agc agc ttc aac gcc ttt gag agc     112
                              Met Ser Ser Phe Asn Ala Phe Glu Ser
                                1               5

 aaa cag cag agt gca gac cag gac gca gaa agc gcc tac aca gag ccc      160
 Lys Gln Gln Ser Ala Asp Gln Asp Ala Glu Ser Ala Tyr Thr Glu Pro
  10                  15                  20                  25

 tac aaa gtc tgt ccc atc tcg tcg gca gcc ccc aaa gag gac ctt acg      208
 Tyr Lys Val Cys Pro Ile Ser Ser Ala Ala Pro Lys Glu Asp Leu Thr
                  30                  35                  40

 tcg gat gaa gag cag aga agc tcg gag gag gag gac agt gct tca aga      256
 Ser Asp Glu Glu Gln Arg Ser Ser Glu Glu Glu Asp Ser Ala Ser Arg
              45                  50                  55

 gac ccc agt gtc acc cac aag gtg gaa gga cag tcc aga gcc ctt gtc      304
 Asp Pro Ser Val Thr His Lys Val Glu Gly Gln Ser Arg Ala Leu Val
          60                  65                  70

 atc gca cag gaa ctg cta tct tca gag aaa gca tac gtg gag atg ctc      352
 Ile Ala Gln Glu Leu Leu Ser Ser Glu Lys Ala Tyr Val Glu Met Leu
      75                  80                  85

 cag cac tta aat ctg gat ttc cat gga gct gtc atg agg gcc ttg gat      400
 Gln His Leu Asn Leu Asp Phe His Gly Ala Val Met Arg Ala Leu Asp
  90                  95                 100                 105

 gac atg gac cat gaa ggc aga gac aca ttg gcc cgg gag gag ctg agg      448
 Asp Met Asp His Glu Gly Arg Asp Thr Leu Ala Arg Glu Glu Leu Arg
                 110                 115                 120

 cag ggc ctg agt gaa ctc cca gcc atc cac gac ctt cat caa ggc atc      496
 Gln Gly Leu Ser Glu Leu Pro Ala Ile His Asp Leu His Gln Gly Ile
             125                 130                 135

 ctg gag gag ctg gag gaa agg ctg tca aat tgg gag agc cag cag aag      544
 Leu Glu Glu Leu Glu Glu Arg Leu Ser Asn Trp Glu Ser Gln Gln Lys
         140                 145                 150

 gta gct gac gtc ttc ctt gcc cgg gag cag ggg ttt gat cac cac gcc      592
 Val Ala Asp Val Phe Leu Ala Arg Glu Gln Gly Phe Asp His His Ala
     155                 160                 165

 act cac atc ctg cag ttc gac agg tac cta ggt ctg ctc agt gag aat      640
 Thr His Ile Leu Gln Phe Asp Arg Tyr Leu Gly Leu Leu Ser Glu Asn
 170                 175                 180                 185

 tgc ctc cac tct ccc cgg ctg gca gct gct gtc cgt gaa ttt gag cag      688
 Cys Leu His Ser Pro Arg Leu Ala Ala Ala Val Arg Glu Phe Glu Gln
                 190                 195                 200

 agt gta caa gga ggc agc cag act gcg aag cat cgg ctg ctg cgg gtg      736
 Ser Val Gln Gly Gly Ser Gln Thr Ala Lys His Arg Leu Leu Arg Val
             205                 210                 215

 gtt caa cgc ctc ttc cag tac caa gtg ctc ctc aca gac tat tta aac      784
 Val Gln Arg Leu Phe Gln Tyr Gln Val Leu Leu Thr Asp Tyr Leu Asn
         220                 225                 230

 aac ctt tgt ccg gac tcc gcc gag tac gac aac aca cag ggt gca ctg      832
 Asn Leu Cys Pro Asp Ser Ala Glu Tyr Asp Asn Thr Gln Gly Ala Leu
     235                 240                 245

 agc ctc atc tcc aaa gtc aca gac cgt gcc aac gac agc atg gag caa      880
 Ser Leu Ile Ser Lys Val Thr Asp Arg Ala Asn Asp Ser Met Glu Gln
 250                 255                 260                 265

 ggg gaa aac ctg cag aag ctg gtc cac att gag cac agc gtc cgg ggc      928
 Gly Glu Asn Leu Gln Lys Leu Val His Ile Glu His Ser Val Arg Gly
                 270                 275                 280

 caa ggg gat ctc ctc cag cca gga agg gag ttt ctg aag gaa ggg acg      976
 Gln Gly Asp Leu Leu Gln Pro Gly Arg Glu Phe Leu Lys Glu Gly Thr
             285                 290                 295

 ctg atg aaa gta aca ggg aaa aac aga cgg ccc cgg cac cta ttt ctg     1024
 Leu Met Lys Val Thr Gly Lys Asn Arg Arg Pro Arg His Leu Phe Leu
         300                 305                 310

 atg aac gat gtg ctc ctg tac acc tat ccc cag aag gat ggg aag tac     1072
 Met Asn Asp Val Leu Leu Tyr Thr Tyr Pro Gln Lys Asp Gly Lys Tyr
     315                 320                 325

 cgg ctg aag aac aca ttg gct gtg gcc aac atg aag gtc agc cgc cct     1120
 Arg Leu Lys Asn Thr Leu Ala Val Ala Asn Met Lys Val Ser Arg Pro
 330                 335                 340                 345

 gtg atg gag aaa gtg ccc tac gct cta aag att gag act tcc gag tcc     1168
 Val Met Glu Lys Val Pro Tyr Ala Leu Lys Ile Glu Thr Ser Glu Ser
                 350                 355                 360

 tgc ctg atg ctg tct gcg agc tcc tgt gca gag agg gac gag tgg tat     1216
 Cys Leu Met Leu Ser Ala Ser Ser Cys Ala Glu Arg Asp Glu Trp Tyr
             365                 370                 375

 ggc tgt ctg agc aga gcc ctc cct gag gac tac aag gcc cag gcg ctg     1264
 Gly Cys Leu Ser Arg Ala Leu Pro Glu Asp Tyr Lys Ala Gln Ala Leu
         380                 385                 390

 gct gca ttc cac cat agc gtg gag ata cga gag agg ctg ggg gtt agc     1312
 Ala Ala Phe His His Ser Val Glu Ile Arg Glu Arg Leu Gly Val Ser
     395                 400                 405

 ctt ggg gag agg ccc ccc acc ctg gtg cct gtc aca cac gtc atg atg     1360
 Leu Gly Glu Arg Pro Pro Thr Leu Val Pro Val Thr His Val Met Met
 410                 415                 420                 425

 tgc atg aac tgc ggc tgc gac ttc tcc ctc acc ctg cgg cgt cat cac     1408
 Cys Met Asn Cys Gly Cys Asp Phe Ser Leu Thr Leu Arg Arg His His
                 430                 435                 440

 tgt cac gcc tgt ggc aag atc gtg tgc cgg aac tgt tcg cgg aac aag     1456
 Cys His Ala Cys Gly Lys Ile Val Cys Arg Asn Cys Ser Arg Asn Lys
             445                 450                 455

 tac ccg ctg aag tac ctg aag gac agg atg gcc aag gtc tgc gac ggc     1504
 Tyr Pro Leu Lys Tyr Leu Lys Asp Arg Met Ala Lys Val Cys Asp Gly
         460                 465                 470

 tgc ttc ggg gag ctg aag aag cgg ggc agg gct gtc ccg ggc ctg atg     1552
 Cys Phe Gly Glu Leu Lys Lys Arg Gly Arg Ala Val Pro Gly Leu Met
     475                 480                 485

 aga gag cgg cct gtg agc atg agc ttc ccg ctg tct tca ccc cgc ttc     1600
 Arg Glu Arg Pro Val Ser Met Ser Phe Pro Leu Ser Ser Pro Arg Phe
 490                 495                 500                 505

 tcg ggc agt gcc ttt tca tcc gtc ttc cag agc att aac ccc tcg acc     1648
 Ser Gly Ser Ala Phe Ser Ser Val Phe Gln Ser Ile Asn Pro Ser Thr
                 510                 515                 520

 ttc aag aag cag aag aaa gtc cct tca gcc ctg aca gag gtg gct gcc     1696
 Phe Lys Lys Gln Lys Lys Val Pro Ser Ala Leu Thr Glu Val Ala Ala
             525                 530                 535

 tct gga gag ggc tct gcc atc agt ggc tat ctc agc cgg tgt aag agg     1744
 Ser Gly Glu Gly Ser Ala Ile Ser Gly Tyr Leu Ser Arg Cys Lys Arg
         540                 545                 550

 ggc aag cgg cac tgg aag aag ctc tgg ttt gtc atc aaa ggc aaa gtt     1792
 Gly Lys Arg His Trp Lys Lys Leu Trp Phe Val Ile Lys Gly Lys Val
     555                 560                 565

 ctc tac acc tac atg gcc agt gag gac aaa gtg gcc ttg gag agt atg     1840
 Leu Tyr Thr Tyr Met Ala Ser Glu Asp Lys Val Ala Leu Glu Ser Met
 570                 575                 580                 585

 cct ctg cta ggc ttc acc att gct cca gaa aag gga gag ggc agc agt     1888
 Pro Leu Leu Gly Phe Thr Ile Ala Pro Glu Lys Gly Glu Gly Ser Ser
                 590                 595                 600

 gaa gta gga cct att ttt cac ctt tac cac aag aaa acc cta ttt tat     1936
 Glu Val Gly Pro Ile Phe His Leu Tyr His Lys Lys Thr Leu Phe Tyr
             605                 610                 615

 agc ttc aaa gca gaa gat acc aat tca gct cag agg tgg atc gag gcc     1984
 Ser Phe Lys Ala Glu Asp Thr Asn Ser Ala Gln Arg Trp Ile Glu Ala
         620                 625                 630

 atg gaa gat gcg agt gtg tta tag cagttatcaa gcatgtggac ttgtaacaaa    2038
 Met Glu Asp Ala Ser Val Leu 
     635                 640

 ttcttaggtc aatatgtgaa tgcttttaga agctaagctg tggctcaact catccggaca   2098

 cacacctgga ttcagcaatg aggcctgacc ttttttgcta taaccgcccc accactcccc   2158

 tgcccttgcc aacatcttca tgaatggaat ccttaaggga tatttatgga cctctccttt   2218

 tctgtgtttt ccacccctac ccccacccgc cacccagtaa taaactattt ccttaccccg   2278

 cagtgagtta aaatttagta agatgaagat gtggaaacca atgaaaagta catttagaaa   2338

 tgcaggcttt ttagtagaaa gaagctctta cagtttttac tcatgataaa tcttatcacc   2398

 tttcaaaaat tgattgtggt gcctcaggtg aaatgagaag ctatcagtaa cagctactct   2458

 catcgaaagc actttattat tttacggagc tgcaacctcc aattttgtgt tttctaagtg   2518

 atttacttaa gtcaataaca gatggaatcc tgtggactaa tgtgccacca gttttctaac   2578

 aagggtgtac ataaaatgga tttgtgcaga cctggctgtg gcttgctggt gtgcaagcac   2638

 acatcacttt agaggggctg cgccccacca gataggaagg ggaggatttt ctcctccagt   2698

 cgaccttgtg acctgtatac taacataact tattaaagga ggggtccctc ctcccccaga   2758

 gcagtcctca acactatgtc agtgctggaa atgcagccac tggcagatct ggccccccag   2818

 acgtcaccgc agggcctctg aagagtcaag gtctgcttta atttattgtg tgcctttctg   2878

 tgtttacctc actcaagctg acaacattgt ttatgggaat ctatccttct tttagacaca   2938

 cggtaatcct tgggctgtat tactgaaggc tttttatttt ttgagaggtg aaaaaaaaaa   2998

 aa                                                                  3000




      <210> 383
      <211> 3637
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (111)..(3413)

      <400> 383
 gtccaagatg gtggcgctag gagccgcgac ccagtgatag cggccgtgga ggggcccccg     60

 accgagcggg aggttggggg tagcctggag attctgaaga caggaataag   atg aag     116
                                                          Met Lys
                                                            1

 gaa tgg aaa tca aag atg gaa att tct gaa gaa aag aag tca gca agg      164
 Glu Trp Lys Ser Lys Met Glu Ile Ser Glu Glu Lys Lys Ser Ala Arg
           5                  10                  15

 gct gca tcc gaa aaa ctc caa aga caa atc acc cag gaa tgt gag tta      212
 Ala Ala Ser Glu Lys Leu Gln Arg Gln Ile Thr Gln Glu Cys Glu Leu
      20                  25                  30

 gtt gaa acc agt aat tct gag gac aga tta ttg aag cac tgg gta agc      260
 Val Glu Thr Ser Asn Ser Glu Asp Arg Leu Leu Lys His Trp Val Ser
  35                  40                  45                  50

 cct tta aag gat gca atg aga cat ctc cct tcc caa gag agc ggt atc      308
 Pro Leu Lys Asp Ala Met Arg His Leu Pro Ser Gln Glu Ser Gly Ile
                  55                  60                  65

 agg gaa atg cat att atc ccc cag aaa gcc att gtg gga gag att ggc      356
 Arg Glu Met His Ile Ile Pro Gln Lys Ala Ile Val Gly Glu Ile Gly
              70                  75                  80

 cat gga tgt aat gaa gga gaa aaa ata ctt tct gca gga gaa agc tcc      404
 His Gly Cys Asn Glu Gly Glu Lys Ile Leu Ser Ala Gly Glu Ser Ser
          85                  90                  95

 cat aga tat gag gtt agt ggc caa aac ttc aaa cag aag tca gga tta      452
 His Arg Tyr Glu Val Ser Gly Gln Asn Phe Lys Gln Lys Ser Gly Leu
     100                 105                 110

 act gaa cat cag aaa att cat aat ata aat aag acc tat gaa tgt aag      500
 Thr Glu His Gln Lys Ile His Asn Ile Asn Lys Thr Tyr Glu Cys Lys
 115                 120                 125                 130

 gaa tgt gaa aaa acc ttc aac agg agt tca aac ctg atc ata cat cag      548
 Glu Cys Glu Lys Thr Phe Asn Arg Ser Ser Asn Leu Ile Ile His Gln
                 135                 140                 145

 aga att cat aca gga aat aag cca tat gtg tgt aat gaa tgt ggg aaa      596
 Arg Ile His Thr Gly Asn Lys Pro Tyr Val Cys Asn Glu Cys Gly Lys
             150                 155                 160

 gac tct aat caa agt tca aat ctt att ata cat cag aga att cat aca      644
 Asp Ser Asn Gln Ser Ser Asn Leu Ile Ile His Gln Arg Ile His Thr
         165                 170                 175

 gga aag aaa cct tat ata tgt cat gaa tgt gga aaa gac ttc aat cag      692
 Gly Lys Lys Pro Tyr Ile Cys His Glu Cys Gly Lys Asp Phe Asn Gln
     180                 185                 190

 agc tcc aat ctg gtg aga cat aag caa att cac agt ggt ggg aat ccc      740
 Ser Ser Asn Leu Val Arg His Lys Gln Ile His Ser Gly Gly Asn Pro
 195                 200                 205                 210

 tat gag tgc aaa gag tgt ggg aag gct ttt aag gga agc tca aac ctt      788
 Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Lys Gly Ser Ser Asn Leu
                 215                 220                 225

 gtc ctg cac cag aga atc cac agt agg ggg aag cca tat tta tgc aat      836
 Val Leu His Gln Arg Ile His Ser Arg Gly Lys Pro Tyr Leu Cys Asn
             230                 235                 240

 aaa tgt ggg aag gct ttc agt caa agc aca gat ctt att ata cat cac      884
 Lys Cys Gly Lys Ala Phe Ser Gln Ser Thr Asp Leu Ile Ile His His
         245                 250                 255

 aga att cac act gga gag aaa ccc tat gaa tgt tat gac tgt gga cag      932
 Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Tyr Asp Cys Gly Gln
     260                 265                 270

 atg ttc agt caa agt tca cac ctt gtc cca cat cag aga att cac act      980
 Met Phe Ser Gln Ser Ser His Leu Val Pro His Gln Arg Ile His Thr
 275                 280                 285                 290

 gga gag aaa ccc ctc aaa tgt aat gaa tgt gaa aaa gcc ttc agg cag     1028
 Gly Glu Lys Pro Leu Lys Cys Asn Glu Cys Glu Lys Ala Phe Arg Gln
                 295                 300                 305

 cat tct cac ctt act gaa cac cag aga ctc cac agt gga gag aaa ccc     1076
 His Ser His Leu Thr Glu His Gln Arg Leu His Ser Gly Glu Lys Pro
             310                 315                 320

 tat gaa tgt cac aga tgt ggg aag acc ttc agt ggg cgc aca gct ttt     1124
 Tyr Glu Cys His Arg Cys Gly Lys Thr Phe Ser Gly Arg Thr Ala Phe
         325                 330                 335

 ctt aaa cat cag aga ttg cat gct gga gag aaa att gaa gaa tgt gag     1172
 Leu Lys His Gln Arg Leu His Ala Gly Glu Lys Ile Glu Glu Cys Glu
     340                 345                 350

 aaa acc ttc agc aag gat gag gag ctt agg gaa gag cag aga att cac     1220
 Lys Thr Phe Ser Lys Asp Glu Glu Leu Arg Glu Glu Gln Arg Ile His
 355                 360                 365                 370

 cag gaa gag aaa gct tat tgg tgt aat cag tgt ggt agg aat ttc cag     1268
 Gln Glu Glu Lys Ala Tyr Trp Cys Asn Gln Cys Gly Arg Asn Phe Gln
                 375                 380                 385

 ggc acc tca gac ctc atc aga cat cag gta act cat aca gga gag aaa     1316
 Gly Thr Ser Asp Leu Ile Arg His Gln Val Thr His Thr Gly Glu Lys
             390                 395                 400

 cca tat gaa tgt aaa gaa tgt ggg aaa act ttc aat cag agc tca gac     1364
 Pro Tyr Glu Cys Lys Glu Cys Gly Lys Thr Phe Asn Gln Ser Ser Asp
         405                 410                 415

 ctt ctg aga cat cat aga att cac agt gga gaa aaa cct tgt gta tgt     1412
 Leu Leu Arg His His Arg Ile His Ser Gly Glu Lys Pro Cys Val Cys
     420                 425                 430

 agc aaa tgt ggg aaa tct ttt agg ggc agc tca gat ctt att aga cac     1460
 Ser Lys Cys Gly Lys Ser Phe Arg Gly Ser Ser Asp Leu Ile Arg His
 435                 440                 445                 450

 cat cgt gtt cat act gga gag aaa ccc tat gaa tgt agt gaa tgt ggg     1508
 His Arg Val His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Glu Cys Gly
                 455                 460                 465

 aaa gcc ttt agc cag agg tca cac ctt gtt aca cac cag aaa atc cat     1556
 Lys Ala Phe Ser Gln Arg Ser His Leu Val Thr His Gln Lys Ile His
             470                 475                 480

 act gga gag aag ccc tat cag tgc act gaa tgt ggg aaa gcc ttc agg     1604
 Thr Gly Glu Lys Pro Tyr Gln Cys Thr Glu Cys Gly Lys Ala Phe Arg
         485                 490                 495

 cgg cgt tca ctc ctt att caa cat cgg aga att cat agt ggt gag aaa     1652
 Arg Arg Ser Leu Leu Ile Gln His Arg Arg Ile His Ser Gly Glu Lys
     500                 505                 510

 ccc tat gaa tgt aag gaa tgt ggg aag ctc ttc att tgg cgc aca gct     1700
 Pro Tyr Glu Cys Lys Glu Cys Gly Lys Leu Phe Ile Trp Arg Thr Ala
 515                 520                 525                 530

 ttc ctc aaa cat cag agc ctg cat act gga gag aaa ctt gaa tgt gag     1748
 Phe Leu Lys His Gln Ser Leu His Thr Gly Glu Lys Leu Glu Cys Glu
                 535                 540                 545

 aaa acc ttc agc cag gat gag gag ctt agg gga gag cag aaa att cac     1796
 Lys Thr Phe Ser Gln Asp Glu Glu Leu Arg Gly Glu Gln Lys Ile His
             550                 555                 560

 cag gaa gcg aaa gct tat tgg tgt aat cag tgt ggt agg gct ttc cag     1844
 Gln Glu Ala Lys Ala Tyr Trp Cys Asn Gln Cys Gly Arg Ala Phe Gln
         565                 570                 575

 ggc agc tca gac ctc atc aga cat cag gta act cat aca aga gag aaa     1892
 Gly Ser Ser Asp Leu Ile Arg His Gln Val Thr His Thr Arg Glu Lys
     580                 585                 590

 cca tat gaa tgc aaa gaa tgt ggg aaa act ttc aat cag agc tca gac     1940
 Pro Tyr Glu Cys Lys Glu Cys Gly Lys Thr Phe Asn Gln Ser Ser Asp
 595                 600                 605                 610

 ctt ctg aga cat cat aga att cac agt gga gaa aaa cct tat gta tgc     1988
 Leu Leu Arg His His Arg Ile His Ser Gly Glu Lys Pro Tyr Val Cys
                 615                 620                 625

 aac aaa tgt ggg aaa tct ttt agg ggt agc tca gat ctt att aaa cac     2036
 Asn Lys Cys Gly Lys Ser Phe Arg Gly Ser Ser Asp Leu Ile Lys His
             630                 635                 640

 cat cgt att cat act gga gag aaa ccc tat gaa tgt agt gaa tgt ggg     2084
 His Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Glu Cys Gly
         645                 650                 655

 aaa gcc ttc agc cag agg tca cac ctt gct aca cac cag aaa atc cat     2132
 Lys Ala Phe Ser Gln Arg Ser His Leu Ala Thr His Gln Lys Ile His
     660                 665                 670

 act gga gag aaa ccc tat cag tgc agt gaa tgt ggg aat gcc ttc agg     2180
 Thr Gly Glu Lys Pro Tyr Gln Cys Ser Glu Cys Gly Asn Ala Phe Arg
 675                 680                 685                 690

 cgg cgt tcc ctc ctt att caa cat cgg aga ctt cat agt ggt gag aaa     2228
 Arg Arg Ser Leu Leu Ile Gln His Arg Arg Leu His Ser Gly Glu Lys
                 695                 700                 705

 ccc tat gaa tgt aag gaa tgt ggg aaa ctc ttc atg tgg cac acg gct     2276
 Pro Tyr Glu Cys Lys Glu Cys Gly Lys Leu Phe Met Trp His Thr Ala
             710                 715                 720

 ttc ctc aaa cat cag aga ctg cat gct gga gag aaa ctt gaa gaa tgt     2324
 Phe Leu Lys His Gln Arg Leu His Ala Gly Glu Lys Leu Glu Glu Cys
         725                 730                 735

 gag aaa acc ttc agc aag gat gag gag ctt aga aaa gag cag aga act     2372
 Glu Lys Thr Phe Ser Lys Asp Glu Glu Leu Arg Lys Glu Gln Arg Thr
     740                 745                 750

 cac cag gaa aag aaa gtt tat tgg tgt aat cag tgt agt agg acc ttc     2420
 His Gln Glu Lys Lys Val Tyr Trp Cys Asn Gln Cys Ser Arg Thr Phe
 755                 760                 765                 770

 cag ggc agc tca gat ctc atc aga cat cag agc tca gac ctt ctg aga     2468
 Gln Gly Ser Ser Asp Leu Ile Arg His Gln Ser Ser Asp Leu Leu Arg
                 775                 780                 785

 cat cat aga att cac agt gga gaa aaa cct tac gta tgc aat aaa tgt     2516
 His His Arg Ile His Ser Gly Glu Lys Pro Tyr Val Cys Asn Lys Cys
             790                 795                 800

 ggg gaa tct ttt agg agc agc tca gat ctt att aaa cac cat cgt gtt     2564
 Gly Glu Ser Phe Arg Ser Ser Ser Asp Leu Ile Lys His His Arg Val
         805                 810                 815

 cat act gga gag aaa cct cat gaa tgt agt gaa tgt ggg aaa gtc ttt     2612
 His Thr Gly Glu Lys Pro His Glu Cys Ser Glu Cys Gly Lys Val Phe
     820                 825                 830

 agc cag agg tcc cac ctt gtc aca cac cag aaa atc cac act gga gag     2660
 Ser Gln Arg Ser His Leu Val Thr His Gln Lys Ile His Thr Gly Glu
 835                 840                 845                 850

 aag ccc tat cag tgc act gaa tgt gaa aaa gcc ttc agg cgg cgt tca     2708
 Lys Pro Tyr Gln Cys Thr Glu Cys Glu Lys Ala Phe Arg Arg Arg Ser
                 855                 860                 865

 ctc ctt att caa cgt cgg aga att cat agt ggt gag aaa ccc tat gaa     2756
 Leu Leu Ile Gln Arg Arg Arg Ile His Ser Gly Glu Lys Pro Tyr Glu
             870                 875                 880

 tgt aag gaa tgt ggg aaa ctc ttc atg tgg cac aca gct ttc ctc aaa     2804
 Cys Lys Glu Cys Gly Lys Leu Phe Met Trp His Thr Ala Phe Leu Lys
         885                 890                 895

 cat cag aga ctg cat gct gga gag aaa ctt gaa gaa tgt gag aaa acc     2852
 His Gln Arg Leu His Ala Gly Glu Lys Leu Glu Glu Cys Glu Lys Thr
     900                 905                 910

 ttc agc aag gat gag gag ctt agg gga gag cag aaa att cac caa gaa     2900
 Phe Ser Lys Asp Glu Glu Leu Arg Gly Glu Gln Lys Ile His Gln Glu
 915                 920                 925                 930

 gag aaa gct tat tgg tgt aat cag tgt ggt agg gct ttc cag ggc agc     2948
 Glu Lys Ala Tyr Trp Cys Asn Gln Cys Gly Arg Ala Phe Gln Gly Ser
                 935                 940                 945

 tca gac ctc atc gga cat cag gta act cat aca gga gag aaa cca tat     2996
 Ser Asp Leu Ile Gly His Gln Val Thr His Thr Gly Glu Lys Pro Tyr
             950                 955                 960

 gaa tgt aaa gaa tgt ggg aaa act ttc aat cag agc tca gac ctt ctg     3044
 Glu Cys Lys Glu Cys Gly Lys Thr Phe Asn Gln Ser Ser Asp Leu Leu
         965                 970                 975

 aga cat cat aga att cac agt gga gaa aaa cct tat gta tgc aac aaa     3092
 Arg His His Arg Ile His Ser Gly Glu Lys Pro Tyr Val Cys Asn Lys
     980                 985                 990

 tgt ggg aaa tct ttt agg ggc agc tca gat ctt att aga cac cat cgt     3140
 Cys Gly Lys Ser Phe Arg Gly Ser Ser Asp Leu Ile Arg His His Arg
 995                1000                1005                1010

 gtt cat act gga gag aaa ccc tat gaa tgc cct gaa tgt tgg aag gcc     3188
 Val His Thr Gly Glu Lys Pro Tyr Glu Cys Pro Glu Cys Trp Lys Ala
                1015                1020                1025

 ttc agt cag aac tca cac ctt gtc agt cat caa aga att cat acc aga     3236
 Phe Ser Gln Asn Ser His Leu Val Ser His Gln Arg Ile His Thr Arg
            1030                1035                1040

 gag aaa ccc ttt gaa tgt agc aac tgt ggt aag gcc ttc agt ggg tgg     3284
 Glu Lys Pro Phe Glu Cys Ser Asn Cys Gly Lys Ala Phe Ser Gly Trp
        1045                1050                1055

 aca gct ttt ctt aag cac cag aaa ctt cac att gga aag gaa ttt gaa     3332
 Thr Ala Phe Leu Lys His Gln Lys Leu His Ile Gly Lys Glu Phe Glu
    1060                1065                1070

 gac tgt aag agt cta caa aca gga cct att cta ata ggt agc aga aac     3380
 Asp Cys Lys Ser Leu Gln Thr Gly Pro Ile Leu Ile Gly Ser Arg Asn
1075                1080                1085                1090

 cta atg aat gca gta aaa cta gga aaa gtc tga tggagacc acatcttatt     3431
 Leu Met Asn Ala Val Lys Leu Gly Lys Val 
                1095                1100

 gcactacaaa tgagttttat tagaaaaaaa ccatgggaag gtgggaaagc agagaaaata   3491

 cctactggat ttttcaaacg taagtataat caagtggaaa agccaaaagc tcttggacat   3551

 aatcaccttt tttttttctg tctcagaact gacactagaa tatggtccca acgatacaat   3611

 tttttaaatt atttattttt taacat                                        3637




      <210> 384
      <211> 2459
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (249)..(2405)

      <400> 384
 tgcggtaccg gtccggaatt cccgggtcga cccacgcgtc cgcggacgcg tggggctgta     60

 agcttcggcg cctccgcttc acctatggga ctcagactcg ggtcagcctg gcgctccctg    120

 gacagtatga actagtgcac acgctggttg ctcatcaggg caactgggag accatccctg    180

 aggaggatct ggaggtccaa gagaacaatg aggatgctgc tcatgtttta acggaactgg    240

 aggtaacg atg cac cat gct ctc tta cag gaa gtg gac gtt gtg gta gca     290
          Met His His Ala Leu Leu Gln Glu Val Asp Val Val Val Ala
            1               5                  10

 cca tgc caa ggc ctc cgg ccc aca gtg gat gtt ctg ggt gac ttg gtg      338
 Pro Cys Gln Gly Leu Arg Pro Thr Val Asp Val Leu Gly Asp Leu Val
  15                  20                  25                  30

 aat gat ttc ttg cct gtg ata acc tat gca ctc cac aaa gat gaa ctc      386
 Asn Asp Phe Leu Pro Val Ile Thr Tyr Ala Leu His Lys Asp Glu Leu
                  35                  40                  45

 tct gag agg gat gag caa gag ctt cag gaa atc cga aag tat ttc tcc      434
 Ser Glu Arg Asp Glu Gln Glu Leu Gln Glu Ile Arg Lys Tyr Phe Ser
              50                  55                  60

 ttt cct gta ttc ttt ttc aaa gtg ccg aaa ctg ggc tcg gag ata ata      482
 Phe Pro Val Phe Phe Phe Lys Val Pro Lys Leu Gly Ser Glu Ile Ile
          65                  70                  75

 gac tcc tca acc agg aga atg gag agc gaa aga tca ccg ctt tat cgc      530
 Asp Ser Ser Thr Arg Arg Met Glu Ser Glu Arg Ser Pro Leu Tyr Arg
      80                  85                  90

 cag cta att gac ctg ggc tat ctg agc agc agt cac tgg aac tgt ggg      578
 Gln Leu Ile Asp Leu Gly Tyr Leu Ser Ser Ser His Trp Asn Cys Gly
  95                 100                 105                 110

 gct cct ggc cag gat act aaa gct cag agc atg ttg gtg gaa cag agt      626
 Ala Pro Gly Gln Asp Thr Lys Ala Gln Ser Met Leu Val Glu Gln Ser
                 115                 120                 125

 gaa aag ctg aga cac ttg agc aca ttt tct cac cag gtg tta cag act      674
 Glu Lys Leu Arg His Leu Ser Thr Phe Ser His Gln Val Leu Gln Thr
             130                 135                 140

 cgc ctg gtg gat gca gcc aag gcc ctg aac ctg gtg cac tgc cac tgc      722
 Arg Leu Val Asp Ala Ala Lys Ala Leu Asn Leu Val His Cys His Cys
         145                 150                 155

 ctt gac atc ttt att aac cag gca ttt gac atg cag cgg gac ctg cag      770
 Leu Asp Ile Phe Ile Asn Gln Ala Phe Asp Met Gln Arg Asp Leu Gln
     160                 165                 170

 atc act ccc aaa cgt ctg gaa tat act cga aaa aag gag aat gag ttg      818
 Ile Thr Pro Lys Arg Leu Glu Tyr Thr Arg Lys Lys Glu Asn Glu Leu
 175                 180                 185                 190

 tat gaa tca ttg atg aat att gcc aac cga aag cag gag gaa atg aag      866
 Tyr Glu Ser Leu Met Asn Ile Ala Asn Arg Lys Gln Glu Glu Met Lys
                 195                 200                 205

 gat atg att gtt gag aca ctt aat acc atg aag gag gaa ctt ctg gat      914
 Asp Met Ile Val Glu Thr Leu Asn Thr Met Lys Glu Glu Leu Leu Asp
             210                 215                 220

 gat gct act aac atg gag ttt aaa gac gtc att gtc cct gag agt gga      962
 Asp Ala Thr Asn Met Glu Phe Lys Asp Val Ile Val Pro Glu Ser Gly
         225                 230                 235

 gaa cca gta ggc acc aga gag atc aaa tgc tgc atc cga cag atc cag     1010
 Glu Pro Val Gly Thr Arg Glu Ile Lys Cys Cys Ile Arg Gln Ile Gln
     240                 245                 250

 gaa ctc atc atc tcc cga ctt aat cag gca gtg gct aat aag ctg atc     1058
 Glu Leu Ile Ile Ser Arg Leu Asn Gln Ala Val Ala Asn Lys Leu Ile
 255                 260                 265                 270

 agc tca gtg gat tac ctg agg gaa agc ttc gtc gga acc ctg gaa cga     1106
 Ser Ser Val Asp Tyr Leu Arg Glu Ser Phe Val Gly Thr Leu Glu Arg
                 275                 280                 285

 tgt ctg cag agc ctg gag aag tct cag gat gtc tca gtt cac atc acc     1154
 Cys Leu Gln Ser Leu Glu Lys Ser Gln Asp Val Ser Val His Ile Thr
             290                 295                 300

 agt aat tat ctc aaa cag atc tta aat gct gcc tat cat gtt gaa gtc     1202
 Ser Asn Tyr Leu Lys Gln Ile Leu Asn Ala Ala Tyr His Val Glu Val
         305                 310                 315

 acg ttt cac tca ggg tcg tca gtt aca agg atg cta tgg gag caa atc     1250
 Thr Phe His Ser Gly Ser Ser Val Thr Arg Met Leu Trp Glu Gln Ile
     320                 325                 330

 aaa cag atc atc cag cgc atc aca tgg gtg agc cca cct gcc atc act     1298
 Lys Gln Ile Ile Gln Arg Ile Thr Trp Val Ser Pro Pro Ala Ile Thr
 335                 340                 345                 350

 ctg gaa tgg aag agg aag gtg gcc cag gaa gcc att gag agc ctc agc     1346
 Leu Glu Trp Lys Arg Lys Val Ala Gln Glu Ala Ile Glu Ser Leu Ser
                 355                 360                 365

 gcc tcc aaa ttg gct aag agc att tgc agc caa ttc cgg act cgg ctc     1394
 Ala Ser Lys Leu Ala Lys Ser Ile Cys Ser Gln Phe Arg Thr Arg Leu
             370                 375                 380

 aat agt tcc cac gag gct ttt gca gcc tcc ttg cgg cag ctg gaa gct     1442
 Asn Ser Ser His Glu Ala Phe Ala Ala Ser Leu Arg Gln Leu Glu Ala
         385                 390                 395

 ggc cac tca ggc cgg tta gag aaa acg gaa gat cta tgg ctg agg gtt     1490
 Gly His Ser Gly Arg Leu Glu Lys Thr Glu Asp Leu Trp Leu Arg Val
     400                 405                 410

 cgg aaa gat cat gct ccc cgc ctg gcc cgc ctt tct ctg gaa agc cgt     1538
 Arg Lys Asp His Ala Pro Arg Leu Ala Arg Leu Ser Leu Glu Ser Arg
 415                 420                 425                 430

 tct tta cag gat gtc ttg ctt cat cgt aaa cct aaa ctg gga cag gaa     1586
 Ser Leu Gln Asp Val Leu Leu His Arg Lys Pro Lys Leu Gly Gln Glu
                 435                 440                 445

 ctg ggc cgg ggc cag tat ggt gtg gta tac ctg tgt gac aac tgg gga     1634
 Leu Gly Arg Gly Gln Tyr Gly Val Val Tyr Leu Cys Asp Asn Trp Gly
             450                 455                 460

 gga cac ttc cct tgt gcc ctc aaa tca gtt gtc cct cca gat gag aag     1682
 Gly His Phe Pro Cys Ala Leu Lys Ser Val Val Pro Pro Asp Glu Lys
         465                 470                 475

 cac tgg aat gat ctg gct ttg gaa ttt cac tat atg agg tct ctg ccg     1730
 His Trp Asn Asp Leu Ala Leu Glu Phe His Tyr Met Arg Ser Leu Pro
     480                 485                 490

 aag cat gag cga ttg gtg gat ctc cat ggt tca gtc att gac tac aac     1778
 Lys His Glu Arg Leu Val Asp Leu His Gly Ser Val Ile Asp Tyr Asn
 495                 500                 505                 510

 tat ggt ggt ggc tcc agc att gct gtg ctc ctc att atg gag cgg cta     1826
 Tyr Gly Gly Gly Ser Ser Ile Ala Val Leu Leu Ile Met Glu Arg Leu
                 515                 520                 525

 cac cgg gat ctc tac aca ggg ctg aag gct ggg ctg acc ctg gag aca     1874
 His Arg Asp Leu Tyr Thr Gly Leu Lys Ala Gly Leu Thr Leu Glu Thr
             530                 535                 540

 cgt ttg cag ata gca cta gat gtg gtg gag gga atc cgc ttc ctg cac     1922
 Arg Leu Gln Ile Ala Leu Asp Val Val Glu Gly Ile Arg Phe Leu His
         545                 550                 555

 agc cag gga ctt gtc cat cgt gat atc aaa ctg aaa aat gtg ctg ctg     1970
 Ser Gln Gly Leu Val His Arg Asp Ile Lys Leu Lys Asn Val Leu Leu
     560                 565                 570

 gat aag cag aac cgt gcc aag atc act gac tta gga ttc tgc aag cca     2018
 Asp Lys Gln Asn Arg Ala Lys Ile Thr Asp Leu Gly Phe Cys Lys Pro
 575                 580                 585                 590

 gag gcc atg atg tca ggc agc att gtg ggg aca cca atc cat atg gcc     2066
 Glu Ala Met Met Ser Gly Ser Ile Val Gly Thr Pro Ile His Met Ala
                 595                 600                 605

 cct gaa ctt ttc aca ggg aag tac gat aat tcc gtg gat gtc tac gct     2114
 Pro Glu Leu Phe Thr Gly Lys Tyr Asp Asn Ser Val Asp Val Tyr Ala
             610                 615                 620

 ttt gga att ctt ttc tgg tat atc tgc tca ggc tct gtc aag ctc cct     2162
 Phe Gly Ile Leu Phe Trp Tyr Ile Cys Ser Gly Ser Val Lys Leu Pro
         625                 630                 635

 gag gca ttt gag agg tgt gct agc aaa gac cat ctc tgg aac aat gtg     2210
 Glu Ala Phe Glu Arg Cys Ala Ser Lys Asp His Leu Trp Asn Asn Val
     640                 645                 650

 cgg agg ggg gct cgc cca gaa cgt ctt cct gtg ttt gat gag gag tgc     2258
 Arg Arg Gly Ala Arg Pro Glu Arg Leu Pro Val Phe Asp Glu Glu Cys
 655                 660                 665                 670

 tgg cag ttg atg gaa gcc tgt tgg gat ggc gac ccc ttg aag agg cct     2306
 Trp Gln Leu Met Glu Ala Cys Trp Asp Gly Asp Pro Leu Lys Arg Pro
                 675                 680                 685

 ctc ttg ggc att gtc cag ccc atg ctc cag ggc atc atg aat cgg ctc     2354
 Leu Leu Gly Ile Val Gln Pro Met Leu Gln Gly Ile Met Asn Arg Leu
             690                 695                 700

 tgc aag tcc aat tct gag cag cca aac aga gga cta gat gat tct act     2402
 Cys Lys Ser Asn Ser Glu Gln Pro Asn Arg Gly Leu Asp Asp Ser Thr
         705                 710                 715

 tga aagc aaagaccttt ctctttcact ctctagttat ttccttcccc ctcacctttt     2459
 






      <210> 385
      <211> 638
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (37)..(588)

      <400> 385
 atttggccct cgaggccaag aattcggcac gaggcc  atg gac aac tgt ttg gcg      54
                                          Met Asp Asn Cys Leu Ala
                                            1               5

 gcc gca gcg ctg aat ggg gtg gac cga cgt tcc ctg cag cgt tca gca      102
 Ala Ala Ala Leu Asn Gly Val Asp Arg Arg Ser Leu Gln Arg Ser Ala
              10                  15                  20

 agg ctg gct cta gaa gtg ctg gag agg gcc aag agg agg gcg gtg gac      150
 Arg Leu Ala Leu Glu Val Leu Glu Arg Ala Lys Arg Arg Ala Val Asp
          25                  30                  35

 tgg cat gcc ctg gag cgt ccc aaa ggc tgc atg ggg gtc ctt gcc cgg      198
 Trp His Ala Leu Glu Arg Pro Lys Gly Cys Met Gly Val Leu Ala Arg
      40                  45                  50

 gag gcg ccc cac cta gag aaa cag ccg gca gcc ggc ccg cag cgc gtt      246
 Glu Ala Pro His Leu Glu Lys Gln Pro Ala Ala Gly Pro Gln Arg Val
  55                  60                  65                  70

 ctc ccg gga gag aaa tat tat tca tct gtg cca gag gaa gga ggg gca      294
 Leu Pro Gly Glu Lys Tyr Tyr Ser Ser Val Pro Glu Glu Gly Gly Ala
                  75                  80                  85

 acc cat gtc tat cgt tat cac aga ggc gag tcg aag ctg cac atg tgc      342
 Thr His Val Tyr Arg Tyr His Arg Gly Glu Ser Lys Leu His Met Cys
              90                  95                 100

 ttg gac ata ggg aat ggt cag aga aaa gac aga aaa aag aca tcc ctt      390
 Leu Asp Ile Gly Asn Gly Gln Arg Lys Asp Arg Lys Lys Thr Ser Leu
         105                 110                 115

 ggt cct gga ggc agc tat caa ata tca gag cat gct cca gag gca tcc      438
 Gly Pro Gly Gly Ser Tyr Gln Ile Ser Glu His Ala Pro Glu Ala Ser
     120                 125                 130

 cag cct gct gag aac atc tct aag gac ctc tac ata gaa gta tat cca      486
 Gln Pro Ala Glu Asn Ile Ser Lys Asp Leu Tyr Ile Glu Val Tyr Pro
 135                 140                 145                 150

 ggg acc tat tct gtc act gtg ggc tca aat gac tta acc aag aag act      534
 Gly Thr Tyr Ser Val Thr Val Gly Ser Asn Asp Leu Thr Lys Lys Thr
                 155                 160                 165

 cat gtg gta gca gtt gat tct gga caa agc gtg gac ctg gtc ttc cct      582
 His Val Val Ala Val Asp Ser Gly Gln Ser Val Asp Leu Val Phe Pro
             170                 175                 180

 gtg tga tgttgaccat cactgccatc acatcacctt tttttaagta gtaagaataa       638
 Val 






      <210> 386
      <211> 1344
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (514)..(1344)

      <400> 386
 ttaggcaaag tattggcctc caccaccata ggggccagag cttctgcctc caaagttttc     60

 tcccttcttg ggtccaaaat ctgaagactg attgctgtaa ttgccaaaat cactgtagct    120

 tccaccactt ccaaaattgc ttccatcatt accaaatcca ttatagccat ccccactgcc    180

 atcatatcca ccaccaccct ggctgccacc aaagccacta tgaccactaa agtctcctcc    240

 atgaccaaag ttgtcattcc caccaaaacc acctctacaa ccaccaccaa aatttccaga    300

 acctgttcga cctctttggc tggatgaagc actagccatc tcttgctttg acagggcttt    360

 cctaacttca cagttgtggc cattcacaat atggtatttc tgaatgacag tcttatccac    420

 ggagtcatgg tcatcaaagg ttacaaaggc aaagtccctt ttcttgccac tgccatggtc    480

 agtcatgatt tcaatcactt ccatttttcc aaa atg tct aag tca gaa tct ctt     534
                                      Met Ser Lys Ser Glu Ser Leu
                                        1               5

 aaa gag ccc gaa cag ctg cag aaa ctc ctc act gga ggg ttg agc att      582
 Lys Glu Pro Glu Gln Leu Gln Lys Leu Leu Thr Gly Gly Leu Ser Ile
          10                  15                  20

 gaa gca acc aat gag agc ctg agg agc cat ttt gag caa tgg gga acg      630
 Glu Ala Thr Asn Glu Ser Leu Arg Ser His Phe Glu Gln Trp Gly Thr
      25                  30                  35

 ctc acg gac tgt gtg gtc ctg aga gat cca aac act aag tgc tcc agg      678
 Leu Thr Asp Cys Val Val Leu Arg Asp Pro Asn Thr Lys Cys Ser Arg
  40                  45                  50                  55

 ggc ttt ggg ttt gtc aca tat gcc act gtg gag gag gtg gat gca gcc      726
 Gly Phe Gly Phe Val Thr Tyr Ala Thr Val Glu Glu Val Asp Ala Ala
                  60                  65                  70

 aca aat gca agg cca cac aag gtg gat gga aga gtt gtg gaa aca aag      774
 Thr Asn Ala Arg Pro His Lys Val Asp Gly Arg Val Val Glu Thr Lys
              75                  80                  85

 aga gct gtc tca aga gaa gat tcc caa aga cca ggt gct cac tta act      822
 Arg Ala Val Ser Arg Glu Asp Ser Gln Arg Pro Gly Ala His Leu Thr
          90                  95                 100

 gtg aaa aag ttt gga aaa atg gaa gtg att gaa atc atg act gac cat      870
 Val Lys Lys Phe Gly Lys Met Glu Val Ile Glu Ile Met Thr Asp His
     105                 110                 115

 ggc agt ggc aag aaa agg gac ttt gcc ttt gta acc ttt gat gac cat      918
 Gly Ser Gly Lys Lys Arg Asp Phe Ala Phe Val Thr Phe Asp Asp His
 120                 125                 130                 135

 gac tcc gtg gat aag act gtc att cag aaa tac cat att gtg aat ggc      966
 Asp Ser Val Asp Lys Thr Val Ile Gln Lys Tyr His Ile Val Asn Gly
                 140                 145                 150

 cac aac tgt gaa gtt agg aaa gcc ctg tca aag caa gag atg gct agt     1014
 His Asn Cys Glu Val Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser
             155                 160                 165

 gct tca tcc agc caa aga ggt cga aca ggt tct gga aat ttt ggt ggt     1062
 Ala Ser Ser Ser Gln Arg Gly Arg Thr Gly Ser Gly Asn Phe Gly Gly
         170                 175                 180

 ggt tgt aga ggt ggt ttt ggt ggg aat gac aac ttt ggt cat gga gga     1110
 Gly Cys Arg Gly Gly Phe Gly Gly Asn Asp Asn Phe Gly His Gly Gly
     185                 190                 195

 gac ttt agt ggt cat agt ggc ttt ggt ggc agc cag ggt ggt ggt gga     1158
 Asp Phe Ser Gly His Ser Gly Phe Gly Gly Ser Gln Gly Gly Gly Gly
 200                 205                 210                 215

 tat gat ggc agt ggg gat ggc tat aat gga ttt ggt aat gat gga agc     1206
 Tyr Asp Gly Ser Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser
                 220                 225                 230

 aat ttt gga agt ggt gga agc tac agt gat ttt ggc aat tac agc aat     1254
 Asn Phe Gly Ser Gly Gly Ser Tyr Ser Asp Phe Gly Asn Tyr Ser Asn
             235                 240                 245

 cag tct tca gat ttt gga ccc aag aag gga gaa aac ttt gga ggc aga     1302
 Gln Ser Ser Asp Phe Gly Pro Lys Lys Gly Glu Asn Phe Gly Gly Arg
         250                 255                 260

 agc tct ggc ccc tat ggt ggt gga ggc caa tac ttt gcc taa             1344
 Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala 
     265                 270                 275





      <210> 387
      <211> 177
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(177)

      <400> 387
  atg gca ggt cca gaa agt gat gcg caa tac cag ttc act ggt att aaa      48
  Met Ala Gly Pro Glu Ser Asp Ala Gln Tyr Gln Phe Thr Gly Ile Lys
    1               5                  10                  15

 aaa tat ttc aac tct tat act ctc aca ggt aga atg aat tgt gta ctg       96
 Lys Tyr Phe Asn Ser Tyr Thr Leu Thr Gly Arg Met Asn Cys Val Leu
              20                  25                  30

 gtc aca tac aga agc att gct ttg att gtc tta tat ttc aag tta agg      144
 Val Thr Tyr Arg Ser Ile Ala Leu Ile Val Leu Tyr Phe Lys Leu Arg
          35                  40                  45

 tcc aaa aaa act cca gct atg aaa gca aca taa                          177
 Ser Lys Lys Thr Pro Ala Met Lys Ala Thr 
      50                  55





      <210> 388
      <211> 2935
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (240)..(2885)

      <400> 388
 gcgggggccg aagcaccgcc tacgtcgggc tgcgtgacaa tggggccggc ggcagaacgc     60

 agctgcggcg actgcgggtc tcgtgggggc ggagcggtcg ccgctgccgc cgcagctcgg    120

 gtcgggattt gaaagattag aaacttcggg tggagagggc ggcggcgttg aatgtgtggc    180

 ggaagcgctg ggggtcacgg ctccgcgcgc cgccggacag ccggcggcgt ctccacagc     239                                                                 
 atg aat tac ccg ggc cgc ggg tcc cca cgg agc ccc gag cat aac ggc      287
 Met Asn Tyr Pro Gly Arg Gly Ser Pro Arg Ser Pro Glu His Asn Gly
   1               5                  10                  15

 cga ggc ggc ggc ggc ggc gcc tgg gag ctg ggc tca gac gcg agg cca      335
 Arg Gly Gly Gly Gly Gly Ala Trp Glu Leu Gly Ser Asp Ala Arg Pro
              20                  25                  30

 gcg ttc ggc ggc ggc gtc tgc cgc ctc gag cac ctg ccc ggc ggg gac      383
 Ala Phe Gly Gly Gly Val Cys Arg Leu Glu His Leu Pro Gly Gly Asp
          35                  40                  45

 ccg gac gac ggc gac gtg ccc ctg gcc ctg ctg cgc ggg gaa ccc ggg      431
 Pro Asp Asp Gly Asp Val Pro Leu Ala Leu Leu Arg Gly Glu Pro Gly
      50                  55                  60

 ctg cat ttg gcg ccg ggc acc gac gac cac aac cac cac ctc gcg ctg      479
 Leu His Leu Ala Pro Gly Thr Asp Asp His Asn His His Leu Ala Leu
  65                  70                  75                  80

 gac ccc tgc ctc agt gac gag aac tat gac ttt agc tcc gcc gag tcg      527
 Asp Pro Cys Leu Ser Asp Glu Asn Tyr Asp Phe Ser Ser Ala Glu Ser
                  85                  90                  95

 ggc tcc tcg ctg cgc tac tac agc gag ggt gag agc ggc ggc ggc ggc      575
 Gly Ser Ser Leu Arg Tyr Tyr Ser Glu Gly Glu Ser Gly Gly Gly Gly
             100                 105                 110

 ggc ggc agc tcc ttg tcg ctg cat ccg ccg cag cag cct ccg ctg gtc      623
 Gly Gly Ser Ser Leu Ser Leu His Pro Pro Gln Gln Pro Pro Leu Val
         115                 120                 125

 ccg acg aac tcg ggg ggc ggc ggc gcg aca gga ggg tcc ccc ggg gaa      671
 Pro Thr Asn Ser Gly Gly Gly Gly Ala Thr Gly Gly Ser Pro Gly Glu
     130                 135                 140

 agg aaa cgt acc cgg ctt ggc ggc ccg gcg gcc cgg cac cgc tat gag      719
 Arg Lys Arg Thr Arg Leu Gly Gly Pro Ala Ala Arg His Arg Tyr Glu
 145                 150                 155                 160

 gta gtg acg gag ctg ggc ccg gag gag gta cgc tgg ttc tac aag gag      767
 Val Val Thr Glu Leu Gly Pro Glu Glu Val Arg Trp Phe Tyr Lys Glu
                 165                 170                 175

 gac aag aag acc tgg aag ccc ttc atc ggc tac gac tcg ctc cgc atc      815
 Asp Lys Lys Thr Trp Lys Pro Phe Ile Gly Tyr Asp Ser Leu Arg Ile
             180                 185                 190

 gag ctc gcc ttc cgg acc ctg ctg cag acc acg ggt gcc cgg ccc cag      863
 Glu Leu Ala Phe Arg Thr Leu Leu Gln Thr Thr Gly Ala Arg Pro Gln
         195                 200                 205

 ggc ggg gac cgg gac ggc gac cat gtg tgc tcc ccc acg ggc cca gcc      911
 Gly Gly Asp Arg Asp Gly Asp His Val Cys Ser Pro Thr Gly Pro Ala
     210                 215                 220

 tcc agt tcc gga gaa gat gac gat gag gac cgc gcc tgc ggc ttc tgc      959
 Ser Ser Ser Gly Glu Asp Asp Asp Glu Asp Arg Ala Cys Gly Phe Cys
 225                 230                 235                 240

 cag agt acg acg ggg cac gag ccg gag atg gtg gag ctt gtg aac atc     1007
 Gln Ser Thr Thr Gly His Glu Pro Glu Met Val Glu Leu Val Asn Ile
                 245                 250                 255

 gag cct gtg tgc gtg cgg ggc ggc ctc tac gag gtg gat gtg acc caa     1055
 Glu Pro Val Cys Val Arg Gly Gly Leu Tyr Glu Val Asp Val Thr Gln
             260                 265                 270

 gga gag tgc tac ccg gtg tac tgg aac cag gct gat aaa ata cca gta     1103
 Gly Glu Cys Tyr Pro Val Tyr Trp Asn Gln Ala Asp Lys Ile Pro Val
         275                 280                 285

 atg cgt gga cag tgg ttt att gac ggc act tgg cag cct cta gaa gag     1151
 Met Arg Gly Gln Trp Phe Ile Asp Gly Thr Trp Gln Pro Leu Glu Glu
     290                 295                 300

 gaa gaa agt aat tta att gag caa gaa cat ctc aat tgt ttt agg ggc     1199
 Glu Glu Ser Asn Leu Ile Glu Gln Glu His Leu Asn Cys Phe Arg Gly
 305                 310                 315                 320

 cag cag atg cag gaa aat ttc gat att gaa gtg tca aaa tcc ata gat     1247
 Gln Gln Met Gln Glu Asn Phe Asp Ile Glu Val Ser Lys Ser Ile Asp
                 325                 330                 335

 gga aaa gat ggt agt ggt atc aac tat tct gct gtt cat agt ttc aag     1295
 Gly Lys Asp Gly Ser Gly Ile Asn Tyr Ser Ala Val His Ser Phe Lys
             340                 345                 350

 ttg agt cga aac cat gtg gac tgg cac agt gtg gat gaa gta tat ctt     1343
 Leu Ser Arg Asn His Val Asp Trp His Ser Val Asp Glu Val Tyr Leu
         355                 360                 365

 tat agt gat gca aca aca tct aaa att gca aga aca gtt acc caa aaa     1391
 Tyr Ser Asp Ala Thr Thr Ser Lys Ile Ala Arg Thr Val Thr Gln Lys
     370                 375                 380

 ctg gga ttt tct aaa gca tca agt agt ggt acc aga ctt cat aga ggt     1439
 Leu Gly Phe Ser Lys Ala Ser Ser Ser Gly Thr Arg Leu His Arg Gly
 385                 390                 395                 400

 tat gta gaa gaa gcc aca tta gaa gac aag cca tca cag act acc cat     1487
 Tyr Val Glu Glu Ala Thr Leu Glu Asp Lys Pro Ser Gln Thr Thr His
                 405                 410                 415

 att gta ttt gtt gtg cat ggc att ggg cag aaa atg gac caa gga aga     1535
 Ile Val Phe Val Val His Gly Ile Gly Gln Lys Met Asp Gln Gly Arg
             420                 425                 430

 att atc aaa aat aca gct atg atg aga gaa gct gca aga aaa ata gaa     1583
 Ile Ile Lys Asn Thr Ala Met Met Arg Glu Ala Ala Arg Lys Ile Glu
         435                 440                 445

 gaa agg cat ttt tcc aac cat gca aca cat gtt gaa ttt ctg cct gtt     1631
 Glu Arg His Phe Ser Asn His Ala Thr His Val Glu Phe Leu Pro Val
     450                 455                 460

 gag tgg cgg tca aaa ctt act ctt gat gga gac act gtt gat tcc att     1679
 Glu Trp Arg Ser Lys Leu Thr Leu Asp Gly Asp Thr Val Asp Ser Ile
 465                 470                 475                 480

 act cct gac aaa gta cga ggt tta agg gat atg ctg aac agc agt gca     1727
 Thr Pro Asp Lys Val Arg Gly Leu Arg Asp Met Leu Asn Ser Ser Ala
                 485                 490                 495

 atg gac ata atg tat tat act agt cca ctt tat aga gat gaa cta gtt     1775
 Met Asp Ile Met Tyr Tyr Thr Ser Pro Leu Tyr Arg Asp Glu Leu Val
             500                 505                 510

 aaa ggc ctt cag caa gag ctg aat cga ttg tat tcc ctt ttc tgt tct     1823
 Lys Gly Leu Gln Gln Glu Leu Asn Arg Leu Tyr Ser Leu Phe Cys Ser
         515                 520                 525

 cgg aat cca gac ttt gaa gaa aaa ggg ggt aaa gtc tca ata gta tca     1871
 Arg Asn Pro Asp Phe Glu Glu Lys Gly Gly Lys Val Ser Ile Val Ser
     530                 535                 540

 cat tcc ttg gga tgt gta att act tat gac ata atg act ggc tgg aat     1919
 His Ser Leu Gly Cys Val Ile Thr Tyr Asp Ile Met Thr Gly Trp Asn
 545                 550                 555                 560

 cca gtt cgg ctg tat gaa cag ttg ctg caa aag gaa gaa gag ttg cct     1967
 Pro Val Arg Leu Tyr Glu Gln Leu Leu Gln Lys Glu Glu Glu Leu Pro
                 565                 570                 575

 gat gaa cga tgg atg agc tat gaa gaa cga cat ctt ctt gat gaa ctc     2015
 Asp Glu Arg Trp Met Ser Tyr Glu Glu Arg His Leu Leu Asp Glu Leu
             580                 585                 590

 tat ata aca aaa cga cgg ctg aag gaa ata gaa gaa cgg ctt cac gga     2063
 Tyr Ile Thr Lys Arg Arg Leu Lys Glu Ile Glu Glu Arg Leu His Gly
         595                 600                 605

 ttg aaa gca tca tct atg aca caa aca cct gcc tta aaa ttt aag gtt     2111
 Leu Lys Ala Ser Ser Met Thr Gln Thr Pro Ala Leu Lys Phe Lys Val
     610                 615                 620

 gag aat ttc ttc tgt atg gga tcc cca tta gca gtt ttc ttg gcg ttg     2159
 Glu Asn Phe Phe Cys Met Gly Ser Pro Leu Ala Val Phe Leu Ala Leu
 625                 630                 635                 640

 cgt ggc atc cgc cca gga aat act gga agt caa gac cat att ttg cct     2207
 Arg Gly Ile Arg Pro Gly Asn Thr Gly Ser Gln Asp His Ile Leu Pro
                 645                 650                 655

 aga gag att tgt aac cgg tta cta aat att ttt cat cct aca gat cca     2255
 Arg Glu Ile Cys Asn Arg Leu Leu Asn Ile Phe His Pro Thr Asp Pro
             660                 665                 670

 gtg gct tat aga tta gaa cca tta ata ctg aaa cac tac agc aac att     2303
 Val Ala Tyr Arg Leu Glu Pro Leu Ile Leu Lys His Tyr Ser Asn Ile
         675                 680                 685

 tca cct gtc cag atc cac tgg tac aat act tca aat cct tta cct tat     2351
 Ser Pro Val Gln Ile His Trp Tyr Asn Thr Ser Asn Pro Leu Pro Tyr
     690                 695                 700

 gaa cat atg aag cca agc ttt ctc aac cca gct aaa gaa cct acc tca     2399
 Glu His Met Lys Pro Ser Phe Leu Asn Pro Ala Lys Glu Pro Thr Ser
 705                 710                 715                 720

 gtt tca gag aat gaa ggc att tca acc ata cca agc cct gtg acc tca     2447
 Val Ser Glu Asn Glu Gly Ile Ser Thr Ile Pro Ser Pro Val Thr Ser
                 725                 730                 735

 cca gtt ttg tcc cgc cga cac tat gga gaa tct ata aca aat ata ggc     2495
 Pro Val Leu Ser Arg Arg His Tyr Gly Glu Ser Ile Thr Asn Ile Gly
             740                 745                 750

 aaa gca agc ata tta ggg gct gct agc att gga aag gga ctt gga gga     2543
 Lys Ala Ser Ile Leu Gly Ala Ala Ser Ile Gly Lys Gly Leu Gly Gly
         755                 760                 765

 atg ttg ttc tca aga ttt gga cgt tca tct aca aca cag tca tct gaa     2591
 Met Leu Phe Ser Arg Phe Gly Arg Ser Ser Thr Thr Gln Ser Ser Glu
     770                 775                 780

 aca tca aaa gac tca atg gaa gat gag aag aag cca gtt gcc tca cct     2639
 Thr Ser Lys Asp Ser Met Glu Asp Glu Lys Lys Pro Val Ala Ser Pro
 785                 790                 795                 800

 tct gct acc acc gta ggg aca cag acc ctt cca cat agc agt tct ggc     2687
 Ser Ala Thr Thr Val Gly Thr Gln Thr Leu Pro His Ser Ser Ser Gly
                 805                 810                 815

 ttc ctc gat tct gca ttg gag ttg gat cac agg att gat ttt gaa ctc     2735
 Phe Leu Asp Ser Ala Leu Glu Leu Asp His Arg Ile Asp Phe Glu Leu
             820                 825                 830

 aga gaa ggc ctt gtg gag agc cgc tat tgg tca gct gtc acg tcg cat     2783
 Arg Glu Gly Leu Val Glu Ser Arg Tyr Trp Ser Ala Val Thr Ser His
         835                 840                 845

 act gcc tat tgg tca tcc ttg gat gtt gcc ctt ttt ctt tta acc ttc     2831
 Thr Ala Tyr Trp Ser Ser Leu Asp Val Ala Leu Phe Leu Leu Thr Phe
     850                 855                 860

 atg tat aaa cat gag cac gat gat gat gca aaa ccc aat tta gat cca     2879
 Met Tyr Lys His Glu His Asp Asp Asp Ala Lys Pro Asn Leu Asp Pro
 865                 870                 875                 880

 atc tga actcttgaag gacatgaatg gcctaaaact gatttttttt tttttccgtt      2935
 Ile 






      <210> 389
      <211> 3763
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (30)..(2339)

      <400> 389
 ctcccgaaaa gcccgtgaaa caagaggaa  atg gct gcc ttg gac gtg gat agc      53
                                  Met Ala Ala Leu Asp Val Asp Ser
                                    1               5

 ggc ggc ggc ggt ggc ggc ggc ggc ggc cac ggc gag tat ctg cag cag      101
 Gly Gly Gly Gly Gly Gly Gly Gly Gly His Gly Glu Tyr Leu Gln Gln
      10                  15                  20

 cag caa cag cac gga aac ggt gcg gtg gcg gcg gca gcg gcg gcc cag      149
 Gln Gln Gln His Gly Asn Gly Ala Val Ala Ala Ala Ala Ala Ala Gln
  25                  30                  35                  40

 gac act cag ccg tca ccg ctc gct ctg ctg gcc gct acc tgc agc aag      197
 Asp Thr Gln Pro Ser Pro Leu Ala Leu Leu Ala Ala Thr Cys Ser Lys
                  45                  50                  55

 ata ggg ccg cca tcg ccg ggc gac gac gag gag gag gcg gcc gcc gca      245
 Ile Gly Pro Pro Ser Pro Gly Asp Asp Glu Glu Glu Ala Ala Ala Ala
              60                  65                  70

 gcc ggg gcc ccc gcc gcc gcc gga gcg aca ggt gat ttg gct tct gca      293
 Ala Gly Ala Pro Ala Ala Ala Gly Ala Thr Gly Asp Leu Ala Ser Ala
          75                  80                  85

 cag tta gga gga gca cca aac cga tgg gag gtt ttg tca gcc aca cct      341
 Gln Leu Gly Gly Ala Pro Asn Arg Trp Glu Val Leu Ser Ala Thr Pro
      90                  95                 100

 aca act ata aaa gat gaa gct ggt aat cta gtc cag att cca agt gct      389
 Thr Thr Ile Lys Asp Glu Ala Gly Asn Leu Val Gln Ile Pro Ser Ala
 105                 110                 115                 120

 gct act tca agt ggg cag tat gtt ctt ccc ctt cag aat ttg cag aat      437
 Ala Thr Ser Ser Gly Gln Tyr Val Leu Pro Leu Gln Asn Leu Gln Asn
                 125                 130                 135

 caa caa ata ttt tcc gtt gca cca gga tca gat tca tca aat ggt aca      485
 Gln Gln Ile Phe Ser Val Ala Pro Gly Ser Asp Ser Ser Asn Gly Thr
             140                 145                 150

 gtg tcc agt gtt caa tat caa gtg ata cca cag atc cag tca gca gat      533
 Val Ser Ser Val Gln Tyr Gln Val Ile Pro Gln Ile Gln Ser Ala Asp
         155                 160                 165

 ggt cag cag gtt caa att ggt ttc aca ggc tct tca gat aat ggg ggt      581
 Gly Gln Gln Val Gln Ile Gly Phe Thr Gly Ser Ser Asp Asn Gly Gly
     170                 175                 180

 ata aat caa gaa agc agt caa att cag atc att cct ggc tct aat caa      629
 Ile Asn Gln Glu Ser Ser Gln Ile Gln Ile Ile Pro Gly Ser Asn Gln
 185                 190                 195                 200

 acc tta ctt gcc tct gga aca cct tct gct aac atc cag aat ctc ata      677
 Thr Leu Leu Ala Ser Gly Thr Pro Ser Ala Asn Ile Gln Asn Leu Ile
                 205                 210                 215

 cca cag act ggt caa gtc cag gtt cag gga gtt gca att ggt ggt tca      725
 Pro Gln Thr Gly Gln Val Gln Val Gln Gly Val Ala Ile Gly Gly Ser
             220                 225                 230

 tct ttt cct ggt caa acc caa gta gtt gct aat gtg cct ctt ggt ctg      773
 Ser Phe Pro Gly Gln Thr Gln Val Val Ala Asn Val Pro Leu Gly Leu
         235                 240                 245

 cca gga aat att acg ttt gta cca atc aat agt gtc gat cta gat tct      821
 Pro Gly Asn Ile Thr Phe Val Pro Ile Asn Ser Val Asp Leu Asp Ser
     250                 255                 260

 ttg gga ctc tcg ggc agt tct cag aca atg act gca ggc att aat gcc      869
 Leu Gly Leu Ser Gly Ser Ser Gln Thr Met Thr Ala Gly Ile Asn Ala
 265                 270                 275                 280

 gac gga cat ttg ata aac aca gga caa gct atg gat agt tca gac aat      917
 Asp Gly His Leu Ile Asn Thr Gly Gln Ala Met Asp Ser Ser Asp Asn
                 285                 290                 295

 tca gaa agg act ggt gag cgg gtt tct cct gat att aat gaa act aat      965
 Ser Glu Arg Thr Gly Glu Arg Val Ser Pro Asp Ile Asn Glu Thr Asn
             300                 305                 310

 act gat aca gat tta ttt gtg cca aca tcc tct tca tca cag ttg cct     1013
 Thr Asp Thr Asp Leu Phe Val Pro Thr Ser Ser Ser Ser Gln Leu Pro
         315                 320                 325

 gtt acg ata gat agt aca ggt ata tta caa caa aac aca aat agc ttg     1061
 Val Thr Ile Asp Ser Thr Gly Ile Leu Gln Gln Asn Thr Asn Ser Leu
     330                 335                 340

 act aca tct agt ggg cag gtt cat tct tca gat ctt cag gga aat tat     1109
 Thr Thr Ser Ser Gly Gln Val His Ser Ser Asp Leu Gln Gly Asn Tyr
 345                 350                 355                 360

 atc cag tcg cct gtt tct gaa gag aca cag gca cag aat att cag gtt     1157
 Ile Gln Ser Pro Val Ser Glu Glu Thr Gln Ala Gln Asn Ile Gln Val
                 365                 370                 375

 tct aca gca cag cct gtt gta cag cat cta caa ctt caa gag tct cag     1205
 Ser Thr Ala Gln Pro Val Val Gln His Leu Gln Leu Gln Glu Ser Gln
             380                 385                 390

 cag cca acc agt caa gcc caa att gtg caa ggt att aca cca cag aca     1253
 Gln Pro Thr Ser Gln Ala Gln Ile Val Gln Gly Ile Thr Pro Gln Thr
         395                 400                 405

 atc cat ggt gtg caa gcc agt ggt caa aat ata tca caa cag gct ttg     1301
 Ile His Gly Val Gln Ala Ser Gly Gln Asn Ile Ser Gln Gln Ala Leu
     410                 415                 420

 caa aat ctt cag ttg cag ctg aat cct gga acc ttt tta att cag gca     1349
 Gln Asn Leu Gln Leu Gln Leu Asn Pro Gly Thr Phe Leu Ile Gln Ala
 425                 430                 435                 440

 cag aca gtg acc cct tct gga cag gta act tgg caa acg ttt caa gta     1397
 Gln Thr Val Thr Pro Ser Gly Gln Val Thr Trp Gln Thr Phe Gln Val
                 445                 450                 455

 caa ggg gtc cag aac ttg cag aat ttg caa ata cag aat act gct gcc     1445
 Gln Gly Val Gln Asn Leu Gln Asn Leu Gln Ile Gln Asn Thr Ala Ala
             460                 465                 470

 caa caa ata act ttg acg cct gtt caa acc ctc aca ctt ggt caa gtt     1493
 Gln Gln Ile Thr Leu Thr Pro Val Gln Thr Leu Thr Leu Gly Gln Val
         475                 480                 485

 gcg gca ggt gga gcc ttc act tca act cca gtt agt cta agc act ggt     1541
 Ala Ala Gly Gly Ala Phe Thr Ser Thr Pro Val Ser Leu Ser Thr Gly
     490                 495                 500

 cag ttg cca aat cta caa aca gtt aca gtg aac tct ata gat tct gct     1589
 Gln Leu Pro Asn Leu Gln Thr Val Thr Val Asn Ser Ile Asp Ser Ala
 505                 510                 515                 520

 ggt ata cag cta cat cca gga gag aat gct gac agt cct gca gat att     1637
 Gly Ile Gln Leu His Pro Gly Glu Asn Ala Asp Ser Pro Ala Asp Ile
                 525                 530                 535

 agg atc aag gaa gaa gaa cct gat cct gaa gag tgg cag ctc agt ggt     1685
 Arg Ile Lys Glu Glu Glu Pro Asp Pro Glu Glu Trp Gln Leu Ser Gly
             540                 545                 550

 gat tct acc ttg aat acc aat gac cta aca cac tta aga gta cag gtg     1733
 Asp Ser Thr Leu Asn Thr Asn Asp Leu Thr His Leu Arg Val Gln Val
         555                 560                 565

 gta gat gaa gaa ggg gac caa caa cat caa gaa gga aaa aga ctt cgg     1781
 Val Asp Glu Glu Gly Asp Gln Gln His Gln Glu Gly Lys Arg Leu Arg
     570                 575                 580

 agg gta gct tgc acc tgt ccc aac tgt aaa gaa ggt ggt gga aga ggt     1829
 Arg Val Ala Cys Thr Cys Pro Asn Cys Lys Glu Gly Gly Gly Arg Gly
 585                 590                 595                 600

 acc aat ctt ggg aaa aag aag caa cac att tgt cat ata cca gga tgt     1877
 Thr Asn Leu Gly Lys Lys Lys Gln His Ile Cys His Ile Pro Gly Cys
                 605                 610                 615

 ggt aaa gtc tat ggg aag acc tca cat ctg aga gct cat ctg cgt tgg     1925
 Gly Lys Val Tyr Gly Lys Thr Ser His Leu Arg Ala His Leu Arg Trp
             620                 625                 630

 cat tct gga gaa cgc cct ttt gtt tgt aac tgg atg tac tgt ggt aaa     1973
 His Ser Gly Glu Arg Pro Phe Val Cys Asn Trp Met Tyr Cys Gly Lys
         635                 640                 645

 aga ttt act cga agt gat gaa tta cag agg cac aga aga aca cat aca     2021
 Arg Phe Thr Arg Ser Asp Glu Leu Gln Arg His Arg Arg Thr His Thr
     650                 655                 660

 ggt gag aag aaa ttt gtt tgt cca gaa tgt tca aaa cgc ttt atg aga     2069
 Gly Glu Lys Lys Phe Val Cys Pro Glu Cys Ser Lys Arg Phe Met Arg
 665                 670                 675                 680

 agt gac cac ctt gcc aaa cat att aaa aca cac cag aat aaa aaa ggt     2117
 Ser Asp His Leu Ala Lys His Ile Lys Thr His Gln Asn Lys Lys Gly
                 685                 690                 695

 att cac tct agc agt aca gtg ctg gca tct gtg gaa gct gcg cga gat     2165
 Ile His Ser Ser Ser Thr Val Leu Ala Ser Val Glu Ala Ala Arg Asp
             700                 705                 710

 gat act ttg att act gca gga gga aca acg ctt atc ctt gca aat att     2213
 Asp Thr Leu Ile Thr Ala Gly Gly Thr Thr Leu Ile Leu Ala Asn Ile
         715                 720                 725

 caa caa ggt tct gtt tca ggg ata gga act gtt aat act tcc gcc acc     2261
 Gln Gln Gly Ser Val Ser Gly Ile Gly Thr Val Asn Thr Ser Ala Thr
     730                 735                 740

 agc aat caa gat atc ctt acc aac act gaa ata cct tta cag ctt gtc     2309
 Ser Asn Gln Asp Ile Leu Thr Asn Thr Glu Ile Pro Leu Gln Leu Val
 745                 750                 755                 760

 aca gtt tct gga aat gag aca atg gag taa a tattacacaa atacttattc     2360
 Thr Val Ser Gly Asn Glu Thr Met Glu 
                 765

 attgtggtta tttttataca gtagtgagaa gaatattgtt cctaagttct tagatatctt   2420

 tttattgatg tgcaaaaatt tttggattga cagtaacttg gttatacatg acactgaaat   2480

 gccttacttt gtatgatatt ccatagtata ttaaaaatgg taaaattgca tgggttttgt   2540

 aggtactttt ggaatctaga agaaatgaaa ttttaccaag ttatataaag agaaaattga   2600

 atttaacaat gcgaatggta gtctaaccaa atgcatcaat cctgtgtggt ttagtgtaaa   2660

 aatgagaaca tgttggtatt tatctattgt aagataaaaa agctggtggg tgaaagaaat   2720

 catgttatga taaaaaattt tgtaattttc ttgatgactg gaatttttat tatgcataac   2780

 tgacaaatca agtttccaag caaatgttac atagtgtagg ctttacttag cttatcaatt   2840

 tgtcattttg aagctaatta ttttaattag gttaactatg tacaatattt taagcattac   2900

 tcttgtaaga ttttgaaaac tacattttaa catggaactc tagggatagt caccttttaa   2960

 atcctgttga aaagccatgt ttaagattta atttgccaaa ataatgtctt gttaatattc   3020

 tttcaataac gaagttgggc aatataacca atgtttaaaa aagtttaaaa tgtataagtt   3080

 gaggcatttg ggtggtaaga gaatgttata gtgaattatc ccttttcttg actattggag   3140

 gaccaaaaaa ataaggtgta ttgcgtctta gcagtgattt ttatccaatc ttgtttccaa   3200

 aaaccatgtc tcccagggcc ttaaaagcca tcatgtaaat taccagtaaa gtgtaacata   3260

 tgcaaacata acaaaatcac ttccatagtg acgatactcc aaccatatgg atattagtca   3320

 tagaagaact agaggtttta tgatattttt ttaagtcttt tttttttttt ctaggaagcc   3380

 agccggcctt aaaaaaaaaa caatttcctt ttttggcttt ttcccttaaa attaatatgt   3440

 atccagtaca ttaaattgaa aagcgtatgt tttttattat gctgtatttt ctttttattt   3500

 tttaattatt gtttatattt tcaattcaaa aatgtacaaa ataaagttac attgctggtc   3560

 tgtgtaagag ctatacagtt ttcctaaatg tatacctgta actgcagcag ttcacctatt   3620

 tgcaaaaatt tggaattctg ttcatttgtt attcttaaga ccacctcaaa tttaaaggct   3680

 accttattgt acgtttaaag tgtattataa cagtgtggta gttaataaaa cactattttt   3740

 ttttcttttg aaaaaaaaaa aaa                                           3763




      <210> 390
      <211> 1626
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1131)

      <400> 390
  atg cca aaa aga cca tct tat gcc cca tct ccc acc cca gct tct gca      48
  Met Pro Lys Arg Pro Ser Tyr Ala Pro Ser Pro Thr Pro Ala Ser Ala
    1               5                  10                  15

 aca cag atg ccc agc aca cca gcg ttt gca gga tac aat cca tac tgt       96
 Thr Gln Met Pro Ser Thr Pro Ala Phe Ala Gly Tyr Asn Pro Tyr Cys
              20                  25                  30

 cat ctt gcc tac agc aac tac agg ctg gga ggg aac cca gcc acc aac      144
 His Leu Ala Tyr Ser Asn Tyr Arg Leu Gly Gly Asn Pro Ala Thr Asn
          35                  40                  45

 agc cgg gtc agg ggg tcc tcc agt att acg att cca aaa ccc cca aag      192
 Ser Arg Val Arg Gly Ser Ser Ser Ile Thr Ile Pro Lys Pro Pro Lys
      50                  55                  60

 cca cca gat aag ccg ctg atg ccc tac atg agg tac agc aga aag gtc      240
 Pro Pro Asp Lys Pro Leu Met Pro Tyr Met Arg Tyr Ser Arg Lys Val
  65                  70                  75                  80

 tgg gac caa gta aag gct tcc aac cct gac gta aag ttg tgg gaa att      288
 Trp Asp Gln Val Lys Ala Ser Asn Pro Asp Val Lys Leu Trp Glu Ile
                  85                  90                  95

 ggc aag att att gct ggc atg tgg caa gat ctt gct gat gaa gag aaa      336
 Gly Lys Ile Ile Ala Gly Met Trp Gln Asp Leu Ala Asp Glu Glu Lys
             100                 105                 110

 caa tat tta aac gaa tat gaa gta gaa aag ata gag tac aat gaa tct      384
 Gln Tyr Leu Asn Glu Tyr Glu Val Glu Lys Ile Glu Tyr Asn Glu Ser
         115                 120                 125

 atg aac gcc cat cat aat tcc ccc gtg tac ctc gct tac ata aat gca      432
 Met Asn Ala His His Asn Ser Pro Val Tyr Leu Ala Tyr Ile Asn Ala
     130                 135                 140

 aaa agt ctt gca gaa gct gct tta gag gaa gac aat aca gcc acc gtc      480
 Lys Ser Leu Ala Glu Ala Ala Leu Glu Glu Asp Asn Thr Ala Thr Val
 145                 150                 155                 160

 cgt ttc cag aga aac cgc cgc ctc atc agt gaa atc ctt agt gag agt      528
 Arg Phe Gln Arg Asn Arg Arg Leu Ile Ser Glu Ile Leu Ser Glu Ser
                 165                 170                 175

 gtg gta cca gag gtt cag tca gtt gtc aca aca act aga atg cag gtc      576
 Val Val Pro Glu Val Gln Ser Val Val Thr Thr Thr Arg Met Gln Val
             180                 185                 190

 ccc aaa caa cag gtc cag tcc tta atg gtt cat cag cga aaa cta gaa      624
 Pro Lys Gln Gln Val Gln Ser Leu Met Val His Gln Arg Lys Leu Glu
         195                 200                 205

 gct gaa ctt ctt cca aaa gag gat cga cac cag gag aag gcg aaa ttc      672
 Ala Glu Leu Leu Pro Lys Glu Asp Arg His Gln Glu Lys Ala Lys Phe
     210                 215                 220

 ctg gaa agc aca gat tca ttt aac aat gaa ctt aaa agg ttg tgc ggt      720
 Leu Glu Ser Thr Asp Ser Phe Asn Asn Glu Leu Lys Arg Leu Cys Gly
 225                 230                 235                 240

 ctg aaa gta gaa gtg gat atg gag aaa att gca gct gag atg gca cag      768
 Leu Lys Val Glu Val Asp Met Glu Lys Ile Ala Ala Glu Met Ala Gln
                 245                 250                 255

 gca gag gaa cag gcc cgc aaa agg cag gag gaa agg gag aag gag gcc      816
 Ala Glu Glu Gln Ala Arg Lys Arg Gln Glu Glu Arg Glu Lys Glu Ala
             260                 265                 270

 gca gag caa gct gag cgc agt cag agc agc atc gtt cct gag gaa gaa      864
 Ala Glu Gln Ala Glu Arg Ser Gln Ser Ser Ile Val Pro Glu Glu Glu
         275                 280                 285

 caa gca gct aac aaa ggc gag gag aag aaa gac gac gag aac att ccg      912
 Gln Ala Ala Asn Lys Gly Glu Glu Lys Lys Asp Asp Glu Asn Ile Pro
     290                 295                 300

 atg gag aca gag gag aca cac ctt gaa gaa aca aca gag agc caa cag      960
 Met Glu Thr Glu Glu Thr His Leu Glu Glu Thr Thr Glu Ser Gln Gln
 305                 310                 315                 320

 aat ggt gaa gaa ggc acg tct act cct gag gac aag gag agt ggg cag     1008
 Asn Gly Glu Glu Gly Thr Ser Thr Pro Glu Asp Lys Glu Ser Gly Gln
                 325                 330                 335

 gag ggg gtc gac agt atg gca gag gaa gga acc agt gat agt aac act     1056
 Glu Gly Val Asp Ser Met Ala Glu Glu Gly Thr Ser Asp Ser Asn Thr
             340                 345                 350

 ggc tcg gag agc aac agt gca aca gtg gag gag cca cca aca gat ccc     1104
 Gly Ser Glu Ser Asn Ser Ala Thr Val Glu Glu Pro Pro Thr Asp Pro
         355                 360                 365

 ata cca gaa gat gag aaa aaa gaa taa gtgtt gccttgtttt gtgtgttcta     1156
 Ile Pro Glu Asp Glu Lys Lys Glu 
     370                 375

 aatacttttt ttaatgaaaa aatgtttttt ggttttaaaa aaacaaaaca aacacaacac   1216

 acacacacaa caaaaaaaac acaaaaaaac aaaaacaaac agcaacaaca gaacatcact   1276

 ccacacaaaa accatcaaaa caaacaaaaa acataacaaa aacagcgccc cccaacaact   1336

 caaggtgagg cgcgcggcaa agctccgacg acgactggga cagaacaagt gaaagaaaag   1396

 gaaccaaagc aaaaagacgc gcacgcgcaa aacagaagaa tagataccaa gcagcgcacg   1456

 cggcagccca caaccacggc gcgtcacgaa atgagacacg ggaccactgt agaaccgcag   1516

 acccccggat gcgtcaagta agagcaagcc aacaagaaac gcacgcggac cacgatagcg   1576

 tggccaagaa aagaacaagc agagcggaac acgcctgacg ggaagaaagc              1626




      <210> 391
      <211> 2811
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (340)..(2757)

      <400> 391
 gccacaagtg atgaggaaag attctttttc gaatataacc agagaaaaaa aggatggaga     60

 aatatctagg acagtgtctt ctcagaaacc accagccttg aaggctacaa gtgtcaagga    120

 agattctgtt ttgaatatag ccagagaaaa aaaggatgga gaaaaatcta ggacagtgtc    180

 ttttgagcaa ccaccaggct tgaaggctac aagagacgag aaagattctc tttgaatata    240

 gccagaggaa aaaaagatgg agaaaaaact aggagagtgt cttctcataa acaaccagcc    300

 ttgaaggcta caagtgacaa ggaaaattct gttccgaat   atg gcc aca gaa aca     354
                                              Met Ala Thr Glu Thr
                                                1               5

 aag gat gaa caa ata tct ggg aca gtg tct tct cag aaa caa cca gcc      402
 Lys Asp Glu Gln Ile Ser Gly Thr Val Ser Ser Gln Lys Gln Pro Ala
                  10                  15                  20

 ttg aag gct aca agt gac aag aaa gat tct gtt tcg aat ata ccc aca      450
 Leu Lys Ala Thr Ser Asp Lys Lys Asp Ser Val Ser Asn Ile Pro Thr
              25                  30                  35

 gaa ata aag gat gga caa caa tct gga aca gtg tct tct cag aaa caa      498
 Glu Ile Lys Asp Gly Gln Gln Ser Gly Thr Val Ser Ser Gln Lys Gln
          40                  45                  50

 ccg gcc tgg aag gct aca agt gtc aag aaa gat tct gtt tcg aat ata      546
 Pro Ala Trp Lys Ala Thr Ser Val Lys Lys Asp Ser Val Ser Asn Ile
      55                  60                  65

 gcc aca gaa ata aag gat gga caa ata cgt ggg aca gtg tct tct cag      594
 Ala Thr Glu Ile Lys Asp Gly Gln Ile Arg Gly Thr Val Ser Ser Gln
  70                  75                  80                  85

 aga cga cca gcc ttg aag act aca ggt gat gag aaa gat tct gtt tcg      642
 Arg Arg Pro Ala Leu Lys Thr Thr Gly Asp Glu Lys Asp Ser Val Ser
                  90                  95                 100

 aat ata gcc aga gaa ata aag gat gga gaa aaa tct ggg aca gtg tct      690
 Asn Ile Ala Arg Glu Ile Lys Asp Gly Glu Lys Ser Gly Thr Val Ser
             105                 110                 115

 cct cag aaa caa tcg gcc cag aag gtt ata ttt aaa aag aaa gtt tct      738
 Pro Gln Lys Gln Ser Ala Gln Lys Val Ile Phe Lys Lys Lys Val Ser
         120                 125                 130

 ctt ttg aat att gcc aca aga ata acg ggc ggt ggg aaa tct gga aca      786
 Leu Leu Asn Ile Ala Thr Arg Ile Thr Gly Gly Gly Lys Ser Gly Thr
     135                 140                 145

 gag tat cct gag aat ctg cgc acc ttg aag gct aca att gaa aat aaa      834
 Glu Tyr Pro Glu Asn Leu Arg Thr Leu Lys Ala Thr Ile Glu Asn Lys
 150                 155                 160                 165

 gat tct gtt ctg aat aca gcc acc aaa atg aaa gat gta caa aca tcc      882
 Asp Ser Val Leu Asn Thr Ala Thr Lys Met Lys Asp Val Gln Thr Ser
                 170                 175                 180

 aca cca gaa caa gac tta gaa atg gca tca gag gga gag caa aag agg      930
 Thr Pro Glu Gln Asp Leu Glu Met Ala Ser Glu Gly Glu Gln Lys Arg
             185                 190                 195

 ctt gaa gaa tat gaa aat aac cag cca cag gtg aaa aac caa ata cat      978
 Leu Glu Glu Tyr Glu Asn Asn Gln Pro Gln Val Lys Asn Gln Ile His
         200                 205                 210

 tct agg gat gac ctt gat gac ata att cag tca tct caa aca gtc tca     1026
 Ser Arg Asp Asp Leu Asp Asp Ile Ile Gln Ser Ser Gln Thr Val Ser
     215                 220                 225

 gag gac ggt gac tcg ctt tgc tgt aat tgt aag aat gtc ata tta ctc     1074
 Glu Asp Gly Asp Ser Leu Cys Cys Asn Cys Lys Asn Val Ile Leu Leu
 230                 235                 240                 245

 att gat caa cat gaa atg aag tgt aaa gat tgt gtt cac cta ttg aaa     1122
 Ile Asp Gln His Glu Met Lys Cys Lys Asp Cys Val His Leu Leu Lys
                 250                 255                 260

 att aaa aag aca ttt tgt tta tgt aaa aga tta aca gaa ctt aaa gat     1170
 Ile Lys Lys Thr Phe Cys Leu Cys Lys Arg Leu Thr Glu Leu Lys Asp
             265                 270                 275

 aat cac tgt gag caa ctt aga gta aaa att cga aaa ctg aaa aat aag     1218
 Asn His Cys Glu Gln Leu Arg Val Lys Ile Arg Lys Leu Lys Asn Lys
         280                 285                 290

 gct agt gta cta caa aag aga cta tct gaa aaa gaa gaa ata aaa tcg     1266
 Ala Ser Val Leu Gln Lys Arg Leu Ser Glu Lys Glu Glu Ile Lys Ser
     295                 300                 305

 cag tta aag cat gaa aca ctt gaa ttg gaa aaa gaa ctc tgt agt ttg     1314
 Gln Leu Lys His Glu Thr Leu Glu Leu Glu Lys Glu Leu Cys Ser Leu
 310                 315                 320                 325

 aga ttt gcc ata cag caa gaa aaa aag aaa aga aga aat gtt gaa gag     1362
 Arg Phe Ala Ile Gln Gln Glu Lys Lys Lys Arg Arg Asn Val Glu Glu
                 330                 335                 340

 gtg cac caa aaa gtt agg gaa aag tta aga atc aca gaa gag caa tat     1410
 Val His Gln Lys Val Arg Glu Lys Leu Arg Ile Thr Glu Glu Gln Tyr
             345                 350                 355

 agg ata gaa gct gat gtg aca aaa cca att aaa ccg gct ctc aaa tca     1458
 Arg Ile Glu Ala Asp Val Thr Lys Pro Ile Lys Pro Ala Leu Lys Ser
         360                 365                 370

 gca gag gtg gaa ttg aag aca gga gga aat aat tca aat cag gtt tct     1506
 Ala Glu Val Glu Leu Lys Thr Gly Gly Asn Asn Ser Asn Gln Val Ser
     375                 380                 385

 gaa act gat gaa aaa gaa gac ctg ctg cat gaa aac cgc ttg atg caa     1554
 Glu Thr Asp Glu Lys Glu Asp Leu Leu His Glu Asn Arg Leu Met Gln
 390                 395                 400                 405

 gat gaa att gcc agg ctc agg ctg gaa aaa gac aca ata aaa aac caa     1602
 Asp Glu Ile Ala Arg Leu Arg Leu Glu Lys Asp Thr Ile Lys Asn Gln
                 410                 415                 420

 aac ctg gaa aag aaa tac tta aaa gac ttt gaa att gtg aaa aga aag     1650
 Asn Leu Glu Lys Lys Tyr Leu Lys Asp Phe Glu Ile Val Lys Arg Lys
             425                 430                 435

 cat gaa gac ctt caa aag gct cta aaa cgg aat ggg gaa aca tta gca     1698
 His Glu Asp Leu Gln Lys Ala Leu Lys Arg Asn Gly Glu Thr Leu Ala
         440                 445                 450

 aaa acg ata gcc tgt tat agt gga cag ctt gct gct ctg aca gat gaa     1746
 Lys Thr Ile Ala Cys Tyr Ser Gly Gln Leu Ala Ala Leu Thr Asp Glu
     455                 460                 465

 aac aca acg ctc cgt tcc aaa ctg gag aag caa aga gag agc agg caa     1794
 Asn Thr Thr Leu Arg Ser Lys Leu Glu Lys Gln Arg Glu Ser Arg Gln
 470                 475                 480                 485

 aga ctg gaa aca gaa atg caa tca tac cat tgt aga ctg aat gct gct     1842
 Arg Leu Glu Thr Glu Met Gln Ser Tyr His Cys Arg Leu Asn Ala Ala
                 490                 495                 500

 cga tgt gat cat gat caa agt cac tca tca aaa aga gac caa gag ctt     1890
 Arg Cys Asp His Asp Gln Ser His Ser Ser Lys Arg Asp Gln Glu Leu
             505                 510                 515

 gct ttc cag ggc aca gta gat aaa tgt cgt cac tta cag gaa aat ttg     1938
 Ala Phe Gln Gly Thr Val Asp Lys Cys Arg His Leu Gln Glu Asn Leu
         520                 525                 530

 aat tct cat gtt ctg att ctt tct ctg caa ctt tct aaa gct gag agt     1986
 Asn Ser His Val Leu Ile Leu Ser Leu Gln Leu Ser Lys Ala Glu Ser
     535                 540                 545

 aag tcc aga gtc ctc aaa act gag ctc cat tac aca gga gag gct ctg     2034
 Lys Ser Arg Val Leu Lys Thr Glu Leu His Tyr Thr Gly Glu Ala Leu
 550                 555                 560                 565

 aaa gaa aag gct ttg gtt ttt gaa cac gtg caa agt gag cta aag caa     2082
 Lys Glu Lys Ala Leu Val Phe Glu His Val Gln Ser Glu Leu Lys Gln
                 570                 575                 580

 aaa cag agt caa atg aag gac att gaa aaa atg tac aaa agt gga tac     2130
 Lys Gln Ser Gln Met Lys Asp Ile Glu Lys Met Tyr Lys Ser Gly Tyr
             585                 590                 595

 aat aca atg gaa aaa tgc ata gaa aaa cag gaa aga ttt tgt caa cta     2178
 Asn Thr Met Glu Lys Cys Ile Glu Lys Gln Glu Arg Phe Cys Gln Leu
         600                 605                 610

 aaa aaa caa aat atg ttg ctt caa cag caa ctg gat gat gct cgc aac     2226
 Lys Lys Gln Asn Met Leu Leu Gln Gln Gln Leu Asp Asp Ala Arg Asn
     615                 620                 625

 aaa gct gac aat caa gaa aaa gca ata ctt aat att caa gcc aga tgt     2274
 Lys Ala Asp Asn Gln Glu Lys Ala Ile Leu Asn Ile Gln Ala Arg Cys
 630                 635                 640                 645

 gat gct aga gta caa aac ctt caa gct gag tgc aga aag cac cgt ctt     2322
 Asp Ala Arg Val Gln Asn Leu Gln Ala Glu Cys Arg Lys His Arg Leu
                 650                 655                 660

 tta cta gaa gaa gac aat aaa atg ttg gtc aat gaa ctg aat cat tcg     2370
 Leu Leu Glu Glu Asp Asn Lys Met Leu Val Asn Glu Leu Asn His Ser
             665                 670                 675

 aaa gaa aaa gaa tgc caa tat gaa aaa gag aaa gca gaa aga gaa gta     2418
 Lys Glu Lys Glu Cys Gln Tyr Glu Lys Glu Lys Ala Glu Arg Glu Val
         680                 685                 690

 gct gtg aga cag ctt caa caa aaa cga gat gat gtc tta aac aaa gga     2466
 Ala Val Arg Gln Leu Gln Gln Lys Arg Asp Asp Val Leu Asn Lys Gly
     695                 700                 705

 tca gca aca aaa gct ctg ctg gat gct tca tcg cgt cac tgc acc tat     2514
 Ser Ala Thr Lys Ala Leu Leu Asp Ala Ser Ser Arg His Cys Thr Tyr
 710                 715                 720                 725

 tta gaa aat ggg atg cag gat tca agg aag aaa tta gac cag atg aga     2562
 Leu Glu Asn Gly Met Gln Asp Ser Arg Lys Lys Leu Asp Gln Met Arg
                 730                 735                 740

 agt caa ttt caa gaa ata cag gat caa ctt aca gct act ata aga tgt     2610
 Ser Gln Phe Gln Glu Ile Gln Asp Gln Leu Thr Ala Thr Ile Arg Cys
             745                 750                 755

 act aag gag atg gaa ggc gac aca caa aag ctt gaa gta gaa cat gtg     2658
 Thr Lys Glu Met Glu Gly Asp Thr Gln Lys Leu Glu Val Glu His Val
         760                 765                 770

 atg atg aga aaa att att aaa aaa cag gat gac caa att gag cgg ctt     2706
 Met Met Arg Lys Ile Ile Lys Lys Gln Asp Asp Gln Ile Glu Arg Leu
     775                 780                 785

 gag aaa atc ctg cag cat tca agt ttg atg ctg cag gtg ttt gag agc     2754
 Glu Lys Ile Leu Gln His Ser Ser Leu Met Leu Gln Val Phe Glu Ser
 790                 795                 800                 805

 tag atga agatatggac atttctggaa ttaagagccc cctctacatt gagcacaagc     2811
 






      <210> 392
      <211> 2710
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (340)..(2610)

      <400> 392
 gccacaagtg atgaggaaag attctttttc gaatataacc agagaaaaaa aggatggaga     60

 aatatctagg acagtgtctt ctcagaaacc accagccttg aaggctacaa gtgtcaagga    120

 agattctgtt ttgaatatag ccagagaaaa aaaggatgga gaaaaatcta ggacagtgtc    180

 ttttgagcaa ccaccaggct tgaaggctac aagagacgag aaagattctc tttgaatata    240

 gccagaggaa aaaaagatgg agaaaaaact aggagagtgt cttctcataa acaaccagcc    300

 ttgaaggcta caagtgacaa ggaaaattct gttccgaat   atg gcc aca gaa aca     354
                                              Met Ala Thr Glu Thr
                                                1               5

 aag gat gaa caa ata tct ggg aca gtg tct tct cag aaa caa cca gcc      402
 Lys Asp Glu Gln Ile Ser Gly Thr Val Ser Ser Gln Lys Gln Pro Ala
                  10                  15                  20

 ttg aag gct aca agt gac aag aaa gat tct gtt tcg aat ata ccc aca      450
 Leu Lys Ala Thr Ser Asp Lys Lys Asp Ser Val Ser Asn Ile Pro Thr
              25                  30                  35

 gaa ata aag gat gga caa caa tct gga aca gtg tct tct cag aaa caa      498
 Glu Ile Lys Asp Gly Gln Gln Ser Gly Thr Val Ser Ser Gln Lys Gln
          40                  45                  50

 ccg gcc tgg aag gct aca agt gtc aag aaa gat tct gtt tcg aat ata      546
 Pro Ala Trp Lys Ala Thr Ser Val Lys Lys Asp Ser Val Ser Asn Ile
      55                  60                  65

 gcc aca gaa ata aag gat gga caa ata cgt ggg aca gtg tct tct cag      594
 Ala Thr Glu Ile Lys Asp Gly Gln Ile Arg Gly Thr Val Ser Ser Gln
  70                  75                  80                  85

 aga cga cca gcc ttg aag act aca ggt gat gag aaa gat tct gtt tcg      642
 Arg Arg Pro Ala Leu Lys Thr Thr Gly Asp Glu Lys Asp Ser Val Ser
                  90                  95                 100

 aat ata gcc aga gaa ata aag gat gga gaa aaa tct ggg aca gtg tct      690
 Asn Ile Ala Arg Glu Ile Lys Asp Gly Glu Lys Ser Gly Thr Val Ser
             105                 110                 115

 cct cag aaa caa tcg gcc cag aag gtt ata ttt aaa aag aaa gtt tct      738
 Pro Gln Lys Gln Ser Ala Gln Lys Val Ile Phe Lys Lys Lys Val Ser
         120                 125                 130

 ctt ttg aat att gcc aca aga ata acg ggc ggt ggg aaa tct gga aca      786
 Leu Leu Asn Ile Ala Thr Arg Ile Thr Gly Gly Gly Lys Ser Gly Thr
     135                 140                 145

 gag tat cct gag aat ctg cgc acc ttg aag gct aca att gaa aat aaa      834
 Glu Tyr Pro Glu Asn Leu Arg Thr Leu Lys Ala Thr Ile Glu Asn Lys
 150                 155                 160                 165

 gat tct gtt ctg aat aca gcc acc aaa atg aaa gat gta caa aca tcc      882
 Asp Ser Val Leu Asn Thr Ala Thr Lys Met Lys Asp Val Gln Thr Ser
                 170                 175                 180

 aca cca gaa caa gac tta gaa atg gca tca gag gga gag caa aag agg      930
 Thr Pro Glu Gln Asp Leu Glu Met Ala Ser Glu Gly Glu Gln Lys Arg
             185                 190                 195

 ctt gaa gaa tat gaa aat aac cag cca cag gtg aaa aac caa ata cat      978
 Leu Glu Glu Tyr Glu Asn Asn Gln Pro Gln Val Lys Asn Gln Ile His
         200                 205                 210

 tct agg gat gac ctt gat gac ata att cag tca tct caa aca gtc tca     1026
 Ser Arg Asp Asp Leu Asp Asp Ile Ile Gln Ser Ser Gln Thr Val Ser
     215                 220                 225

 gag gac ggt gac tcg ctt tgc tgt aat tgt aag aat gtc ata tta ctc     1074
 Glu Asp Gly Asp Ser Leu Cys Cys Asn Cys Lys Asn Val Ile Leu Leu
 230                 235                 240                 245

 att gat caa cat gaa atg aag tgt aaa gat tgt gtt cac cta ttg aaa     1122
 Ile Asp Gln His Glu Met Lys Cys Lys Asp Cys Val His Leu Leu Lys
                 250                 255                 260

 att aaa aag aca ttt tgt tta tgt aaa aga tta aca gaa ctt aaa gat     1170
 Ile Lys Lys Thr Phe Cys Leu Cys Lys Arg Leu Thr Glu Leu Lys Asp
             265                 270                 275

 aat cac tgt gag caa ctt aga gta aaa att cga aaa ctg aaa aat aag     1218
 Asn His Cys Glu Gln Leu Arg Val Lys Ile Arg Lys Leu Lys Asn Lys
         280                 285                 290

 gct agt gta cta caa aag aga cta tct gaa aaa gaa gaa ata aaa tcg     1266
 Ala Ser Val Leu Gln Lys Arg Leu Ser Glu Lys Glu Glu Ile Lys Ser
     295                 300                 305

 cag tta aag cat gaa aca ctt gaa ttg gaa aaa gaa ctc tgt agt ttg     1314
 Gln Leu Lys His Glu Thr Leu Glu Leu Glu Lys Glu Leu Cys Ser Leu
 310                 315                 320                 325

 aga ttt gcc ata cag caa gaa aaa aag aaa aga aga aat gtt gaa gag     1362
 Arg Phe Ala Ile Gln Gln Glu Lys Lys Lys Arg Arg Asn Val Glu Glu
                 330                 335                 340

 gtg cac caa aaa gtt agg gaa aag tta aga atc aca gaa gag caa tat     1410
 Val His Gln Lys Val Arg Glu Lys Leu Arg Ile Thr Glu Glu Gln Tyr
             345                 350                 355

 agg ata gaa gct gat gtg aca aaa cca att aaa ccg gct ctc aaa tca     1458
 Arg Ile Glu Ala Asp Val Thr Lys Pro Ile Lys Pro Ala Leu Lys Ser
         360                 365                 370

 gca gag gtg gaa ttg aag aca gga gga aat aat tca aat cag gtt tct     1506
 Ala Glu Val Glu Leu Lys Thr Gly Gly Asn Asn Ser Asn Gln Val Ser
     375                 380                 385

 gaa act gat gaa aaa gaa gac ctg ctg cat gaa aac cgc ttg atg caa     1554
 Glu Thr Asp Glu Lys Glu Asp Leu Leu His Glu Asn Arg Leu Met Gln
 390                 395                 400                 405

 gat gaa att gcc agg ctc agg ctg gaa aaa gac aca ata aaa aac caa     1602
 Asp Glu Ile Ala Arg Leu Arg Leu Glu Lys Asp Thr Ile Lys Asn Gln
                 410                 415                 420

 aac ctg gaa aag aaa tac tta aaa gac ttt gaa att gtg aaa aga aag     1650
 Asn Leu Glu Lys Lys Tyr Leu Lys Asp Phe Glu Ile Val Lys Arg Lys
             425                 430                 435

 cat gaa gac ctt caa aag gct cta aaa cgg aat ggg gaa aca tta gca     1698
 His Glu Asp Leu Gln Lys Ala Leu Lys Arg Asn Gly Glu Thr Leu Ala
         440                 445                 450

 aaa acg ata gcc tgt tat agt gga cag ctt gct gct ctg aca gat gaa     1746
 Lys Thr Ile Ala Cys Tyr Ser Gly Gln Leu Ala Ala Leu Thr Asp Glu
     455                 460                 465

 aac aca acg ctc cgt tcc aaa ctg gag aag caa aga gag agc agg caa     1794
 Asn Thr Thr Leu Arg Ser Lys Leu Glu Lys Gln Arg Glu Ser Arg Gln
 470                 475                 480                 485

 aga ctg gaa aca gaa atg caa tca tac cat tgt aga ctg aat gct gct     1842
 Arg Leu Glu Thr Glu Met Gln Ser Tyr His Cys Arg Leu Asn Ala Ala
                 490                 495                 500

 cga tgt gat cat gat caa agt cac tca tca aaa aga gac caa gag ctt     1890
 Arg Cys Asp His Asp Gln Ser His Ser Ser Lys Arg Asp Gln Glu Leu
             505                 510                 515

 gct ttc cag ggc aca gta gat aaa tgt cgt cac tta cag gaa aat ttg     1938
 Ala Phe Gln Gly Thr Val Asp Lys Cys Arg His Leu Gln Glu Asn Leu
         520                 525                 530

 aat tct cat gtt ctg att ctt tct ctg caa ctt tct aaa gct gag agt     1986
 Asn Ser His Val Leu Ile Leu Ser Leu Gln Leu Ser Lys Ala Glu Ser
     535                 540                 545

 aag tcc aga gtc ctc aaa act gag ctc cat tac aca gga gag gct ctg     2034
 Lys Ser Arg Val Leu Lys Thr Glu Leu His Tyr Thr Gly Glu Ala Leu
 550                 555                 560                 565

 aaa gaa aag gct ttg gtt ttt gaa cac gtg caa agt gag cta aag caa     2082
 Lys Glu Lys Ala Leu Val Phe Glu His Val Gln Ser Glu Leu Lys Gln
                 570                 575                 580

 aaa cag agt caa atg aag gac att gaa aaa atg tac aaa agt gga tac     2130
 Lys Gln Ser Gln Met Lys Asp Ile Glu Lys Met Tyr Lys Ser Gly Tyr
             585                 590                 595

 aat aca atg gaa aaa tgc ata gaa aaa cag gaa aga ttt tgt caa cta     2178
 Asn Thr Met Glu Lys Cys Ile Glu Lys Gln Glu Arg Phe Cys Gln Leu
         600                 605                 610

 aaa aaa caa aat atg ttg ctt caa cag caa ctg gat gat gct cgc aac     2226
 Lys Lys Gln Asn Met Leu Leu Gln Gln Gln Leu Asp Asp Ala Arg Asn
     615                 620                 625

 aaa gct gac aat caa gaa aaa gca ata ctt aat att caa gcc aga tgt     2274
 Lys Ala Asp Asn Gln Glu Lys Ala Ile Leu Asn Ile Gln Ala Arg Cys
 630                 635                 640                 645

 gat gct aga gta caa aac ctt caa gct gag tgc aga aag cac cgt ctt     2322
 Asp Ala Arg Val Gln Asn Leu Gln Ala Glu Cys Arg Lys His Arg Leu
                 650                 655                 660

 tta cta gaa gaa gac aat aaa atg ttg gtc aat gaa ctg aat cat tcg     2370
 Leu Leu Glu Glu Asp Asn Lys Met Leu Val Asn Glu Leu Asn His Ser
             665                 670                 675

 aaa gaa aaa gaa tgc caa tat gaa aaa gag aaa gca gaa aga gaa gta     2418
 Lys Glu Lys Glu Cys Gln Tyr Glu Lys Glu Lys Ala Glu Arg Glu Val
         680                 685                 690

 gct gtg aga cag ctt caa caa aaa cga gat gat gtc tta aac aaa gga     2466
 Ala Val Arg Gln Leu Gln Gln Lys Arg Asp Asp Val Leu Asn Lys Gly
     695                 700                 705

 tca gca aca aaa gct ctg ctg gat gct tca tcg cgt cac tgc acc tat     2514
 Ser Ala Thr Lys Ala Leu Leu Asp Ala Ser Ser Arg His Cys Thr Tyr
 710                 715                 720                 725

 tta gaa aat ggg atg cag gat tca agg aag aaa tta gac cag atg aga     2562
 Leu Glu Asn Gly Met Gln Asp Ser Arg Lys Lys Leu Asp Gln Met Arg
                 730                 735                 740

 agt caa gta tgt atg caa ctt tgc aca cca aca act gtt aat ctg tag     2610
 Ser Gln Val Cys Met Gln Leu Cys Thr Pro Thr Thr Val Asn Leu 
             745                 750                 755

 ctagttaact aatataaagt gttttggggt actaatttta gtggatggct ttcttttgta   2670

 tttttatgat aattaatgtt attaaaattt tatagtggaa                         2710




      <210> 393
      <211> 2383
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (138)..(1526)

      <400> 393
 tttcgtgcgg gacctggggc ggagagcggt tcgcgcgctt cgggcctagt ccggactcgc     60

 cgccgccgcc gccatattcc cgtggcatct tccttacttt gtccatcctc cggactcgcg    120

 atcttccttc cggagcc   atg tca gaa gga gtg gac ttg att gat ata tat     170
                      Met Ser Glu Gly Val Asp Leu Ile Asp Ile Tyr
                        1               5                  10

 gct gac gag gag ttc aac cag gac cca gag ttc aac aat aca gat cag      218
 Ala Asp Glu Glu Phe Asn Gln Asp Pro Glu Phe Asn Asn Thr Asp Gln
              15                  20                  25

 att gac ctg tat gat gat gtg ctg aca gcc acc tca cag ccc tca gat      266
 Ile Asp Leu Tyr Asp Asp Val Leu Thr Ala Thr Ser Gln Pro Ser Asp
          30                  35                  40

 gac aga agc agc agc act gaa cca cct cct cct gtt cgc cag gag cca      314
 Asp Arg Ser Ser Ser Thr Glu Pro Pro Pro Pro Val Arg Gln Glu Pro
      45                  50                  55

 tct ccc aag ccc aac aac aag acc cct gca att ctg tat acc tac agt      362
 Ser Pro Lys Pro Asn Asn Lys Thr Pro Ala Ile Leu Tyr Thr Tyr Ser
  60                  65                  70                  75

 ggc ctg cgt aat aga cga gct gcc gtt tat gtg ggc agc ttc tcc tgg      410
 Gly Leu Arg Asn Arg Arg Ala Ala Val Tyr Val Gly Ser Phe Ser Trp
                  80                  85                  90

 tgg acc aca gac cag cag ctg atc cag gtt att cgc tct ata gga gtc      458
 Trp Thr Thr Asp Gln Gln Leu Ile Gln Val Ile Arg Ser Ile Gly Val
              95                 100                 105

 tat gat gtg gtg gag ttg aaa ttt gca gag aat cga gca aat ggc cag      506
 Tyr Asp Val Val Glu Leu Lys Phe Ala Glu Asn Arg Ala Asn Gly Gln
         110                 115                 120

 tcc aaa ggg tat gct gag gtg gtg gta gcc tct gaa aac tct gtc cac      554
 Ser Lys Gly Tyr Ala Glu Val Val Val Ala Ser Glu Asn Ser Val His
     125                 130                 135

 aaa ttg ttg gaa ctc cta cca ggg aaa gtt ctt aat gga gaa aaa gtg      602
 Lys Leu Leu Glu Leu Leu Pro Gly Lys Val Leu Asn Gly Glu Lys Val
 140                 145                 150                 155

 gac gtg agg ccg gcc acc cgg cag aac ctg tca cag ttt gag gca cag      650
 Asp Val Arg Pro Ala Thr Arg Gln Asn Leu Ser Gln Phe Glu Ala Gln
                 160                 165                 170

 gct cgg aaa cga ata cct cca cgg gcc cat tcc cga gat tct agt gat      698
 Ala Arg Lys Arg Ile Pro Pro Arg Ala His Ser Arg Asp Ser Ser Asp
             175                 180                 185

 tct gct gat gga cgg gcc aca ccc tct gag aac ctt gta ccc tca tct      746
 Ser Ala Asp Gly Arg Ala Thr Pro Ser Glu Asn Leu Val Pro Ser Ser
         190                 195                 200

 gct cgt gtg gat aag ccc ccc agt gtg ctg ccc tac ttc aat cgt cct      794
 Ala Arg Val Asp Lys Pro Pro Ser Val Leu Pro Tyr Phe Asn Arg Pro
     205                 210                 215

 cct tcg gcc ctt ccc ctg atg ggt ctg ccc cca cca cca att cca ccc      842
 Pro Ser Ala Leu Pro Leu Met Gly Leu Pro Pro Pro Pro Ile Pro Pro
 220                 225                 230                 235

 cca cca cct ctc tcc tca agc ttt ggg gtc cct cct cct cct cct ggt      890
 Pro Pro Pro Leu Ser Ser Ser Phe Gly Val Pro Pro Pro Pro Pro Gly
                 240                 245                 250

 atc cac tac cag cat ctc atg ccc cca cct cct cga tta cct cct cat      938
 Ile His Tyr Gln His Leu Met Pro Pro Pro Pro Arg Leu Pro Pro His
             255                 260                 265

 ctt gct gta cct ccc cct ggg gcc atc cca cct gcc ctt cac ctc aat      986
 Leu Ala Val Pro Pro Pro Gly Ala Ile Pro Pro Ala Leu His Leu Asn
         270                 275                 280

 cca gcc ttc ttc ccc cca gca aac gct aca gtg ggg cct cca cca gat     1034
 Pro Ala Phe Phe Pro Pro Ala Asn Ala Thr Val Gly Pro Pro Pro Asp
     285                 290                 295

 act tac atg aag gcc tct gcc ccc tat aac cac cat ggc agc cga gat     1082
 Thr Tyr Met Lys Ala Ser Ala Pro Tyr Asn His His Gly Ser Arg Asp
 300                 305                 310                 315

 tcg ggc cct cca ccc tct aca gtg agt gaa gcc gaa ttt gaa gat atc     1130
 Ser Gly Pro Pro Pro Ser Thr Val Ser Glu Ala Glu Phe Glu Asp Ile
                 320                 325                 330

 atg aag cga aac aga gca att tcc agc agt gcc att tcc aaa gca gta     1178
 Met Lys Arg Asn Arg Ala Ile Ser Ser Ser Ala Ile Ser Lys Ala Val
             335                 340                 345

 tct gga gcc agt gca ggg gat tac agt gac gca att gag acg ctg ctc     1226
 Ser Gly Ala Ser Ala Gly Asp Tyr Ser Asp Ala Ile Glu Thr Leu Leu
         350                 355                 360

 aca gcc att gcg gtt atc aaa cag tcc cgg gtt gcc aat gat gag cgt     1274
 Thr Ala Ile Ala Val Ile Lys Gln Ser Arg Val Ala Asn Asp Glu Arg
     365                 370                 375

 tgc cgt gtc ctc atc tcc tct ctt aag gac tgt ctt cat ggc att gaa     1322
 Cys Arg Val Leu Ile Ser Ser Leu Lys Asp Cys Leu His Gly Ile Glu
 380                 385                 390                 395

 gcc aag tcc tac agt gtg ggt gcc agt ggg agc tct tcc agg aaa aga     1370
 Ala Lys Ser Tyr Ser Val Gly Ala Ser Gly Ser Ser Ser Arg Lys Arg
                 400                 405                 410

 cat cgc tcc cgg gaa agg tca cct agc cgg tcc cgg gag agc agc agg     1418
 His Arg Ser Arg Glu Arg Ser Pro Ser Arg Ser Arg Glu Ser Ser Arg
             415                 420                 425

 agg cac cgg gat ctg ctt cat aat gaa gat cgg cat gat gat tat ttc     1466
 Arg His Arg Asp Leu Leu His Asn Glu Asp Arg His Asp Asp Tyr Phe
         430                 435                 440

 caa gaa agg aac cgg gag cat gag aga cac cgg gat aga gaa cgg gac     1514
 Gln Glu Arg Asn Arg Glu His Glu Arg His Arg Asp Arg Glu Arg Asp
     445                 450                 455

 cgg cac cac tga gaa aggagtctgg ttggaagcaa atgttttttt aatggacttg     1569
 Arg His His 
 460

 catctcctca ccttgatcag gactaaagga cggaggccgc cccaccccct tccctttcct   1629

 ccaaacccct aactccctcc agacacccag ggaataccct ctgccccaca ggattgaaga   1689

 ctgcttggca gtcctcccaa tcccacacct cctgtttgcc aggggaaaga acctaaagac   1749

 ttcgtgtgat tgggaggggt ggcagacagg aagaaaacat gtccaggccc ctggtctcca   1809

 tagagaatgg tgctttgtcc aagaaaacgt atgagtttct gattctccgg gagccgttca   1869

 atggtgaggt tgatgggaag acttccttcc caaagaaaat agatcctcca tgcaggatct   1929

 aggagagtga ctgggtgtgc caaaatatgc ccagggtcct gccctcagca ctagatttaa   1989

 tggggccaag agggtccaaa ccccttgcta acataccact tctttgttta actcctttac   2049

 ctttccagcc ctttgaggag ggaccatgag aacagaaatt accttatgaa aagctacttc   2109

 tgttcctgct ttccctctca cgtattgacg gtttatttct ttgacctccc agagggctga   2169

 actctttcaa ctctgcgctg cccagccttt tcaggggact tgcccctcct aagcagagaa   2229

 ggcctaggtg ctgtgtggga gctggcacgc atacaccctc tgcgtgtggt ggcctgagac   2289

 gacgctagtg gctccggggc ataagagggc cccagatctt gaaagagccg gggggcggca   2349

 caaaatgaag gggaggggca cacttgggac cacc                               2383




      <210> 394
      <211> 1635
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (378)..(1178)

      <400> 394
 cagcaaacag tttctttaac actttgttgg gcaaccattc tttgaatttg aggaaacgga     60

 cctattattc ttttctttga attggggggg gggctggggt ggaaatcagg ttccgggatt    120

 gcagaggtct tcagttttta cttacaaccc aaagggaaga gctaaataaa tgccaaaacc    180

 tagtaaaaga ggctgtaaaa aacctggagg gacctccatc tcgtaatgtt attgagtctg    240

 caacagtctg tcacctccga ccagccagac ttcctctcaa ctgctgtgtc ttttgtaaag    300

 ctgatgaatt gttcacagag tatgaatcaa agctattttc caacacagtc aaaggccaga    360

 ctgcaatatt tgaggag   atg ata gaa gat gaa gaa gga ctg gtg gat gat     410
                      Met Ile Glu Asp Glu Glu Gly Leu Val Asp Asp
                        1               5                  10

 cga gca cct acc acc acc cgg ggt ctc tgg gca ata agt gag aca gag      458
 Arg Ala Pro Thr Thr Thr Arg Gly Leu Trp Ala Ile Ser Glu Thr Glu
              15                  20                  25

 cga tct atg aaa gca ata cta tca ttt gca aaa tca cat agg ttt gat      506
 Arg Ser Met Lys Ala Ile Leu Ser Phe Ala Lys Ser His Arg Phe Asp
          30                  35                  40

 gtt gaa ttt gtt gat gaa gga agc act tca atg gat ctc ttt gaa gca      554
 Val Glu Phe Val Asp Glu Gly Ser Thr Ser Met Asp Leu Phe Glu Ala
      45                  50                  55

 tgg aag aag gaa tat aag ttg ctt cat gaa tat tgg atg gct ctg agg      602
 Trp Lys Lys Glu Tyr Lys Leu Leu His Glu Tyr Trp Met Ala Leu Arg
  60                  65                  70                  75

 aat cgt gtg tct gct gtt gat gaa ctt gca atg gct aca gaa cga cta      650
 Asn Arg Val Ser Ala Val Asp Glu Leu Ala Met Ala Thr Glu Arg Leu
                  80                  85                  90

 aga gtg cgt gat cct agg gag cca aag cct aat ccg cct gtt ctt cat      698
 Arg Val Arg Asp Pro Arg Glu Pro Lys Pro Asn Pro Pro Val Leu His
              95                 100                 105

 atc att gaa cca cat gag gta gaa caa aac cga ata aaa cta cta aat      746
 Ile Ile Glu Pro His Glu Val Glu Gln Asn Arg Ile Lys Leu Leu Asn
         110                 115                 120

 gat aaa gct gtt gct aca tca cag ctt cag aaa aaa ctt ggg cag ctt      794
 Asp Lys Ala Val Ala Thr Ser Gln Leu Gln Lys Lys Leu Gly Gln Leu
     125                 130                 135

 ctt tac cta act aat ttg gag aag tct caa gat aaa aca tcg gga ggt      842
 Leu Tyr Leu Thr Asn Leu Glu Lys Ser Gln Asp Lys Thr Ser Gly Gly
 140                 145                 150                 155

 gtt aat cca gaa cct tgt cca atc tgt gct cga cag cta gga aaa cag      890
 Val Asn Pro Glu Pro Cys Pro Ile Cys Ala Arg Gln Leu Gly Lys Gln
                 160                 165                 170

 tgg gcg gta ctg acc tgt ggt cac tgt ttc tgt aat gaa tgc att tct      938
 Trp Ala Val Leu Thr Cys Gly His Cys Phe Cys Asn Glu Cys Ile Ser
             175                 180                 185

 ata att att gaa caa tac agc gtg gga tct cac aga agc tcc att aag      986
 Ile Ile Ile Glu Gln Tyr Ser Val Gly Ser His Arg Ser Ser Ile Lys
         190                 195                 200

 tgt gca atc tgc cgc cag acc aca tct cac aaa gaa atc tcg tat gtc     1034
 Cys Ala Ile Cys Arg Gln Thr Thr Ser His Lys Glu Ile Ser Tyr Val
     205                 210                 215

 ttt acc tca gag aaa gca aac cag gag gag gac atc cct gtg aag ggc     1082
 Phe Thr Ser Glu Lys Ala Asn Gln Glu Glu Asp Ile Pro Val Lys Gly
 220                 225                 230                 235

 agc cat tct aca aaa gtg gaa gct gtg gtc aga act ctg atg aaa ata     1130
 Ser His Ser Thr Lys Val Glu Ala Val Val Arg Thr Leu Met Lys Ile
                 240                 245                 250

 cag ctt aga gat cca ggg gcc aaa gca ctc gtt ttc tca acg gta taa     1178
 Gln Leu Arg Asp Pro Gly Ala Lys Ala Leu Val Phe Ser Thr Val 
             255                 260                 265

 tcaacatttt catcctcaat attaattcga actgattttc cctctctaat cagtttacag   1238

 ctgagaacta atttttgatg tttactctta gatttttttt cccaaatcca taagatagaa   1298

 ttatttttag agaagataga attattttta gagaaatgtg atgatgtttc acaaggcaat   1358

 ttgtatagct atatttcatg actttttatt agtttcattt aaggattttc ttagtttaat   1418

 atttttaaaa ttggaatttc tgactttgaa agtctcattt cacaaaaatt tgggttgaaa   1478

 aagacaatct actttataaa gtgttgagta aaacccttag ttttcatttt cgaaaactaa   1538

 gtaactatat tccagtatgc actccattat gtattttcta ctgtttgttt atcttaatta   1598

 cattttcaaa accagcattt gatgcaaaaa aaaaaaa                            1635




      <210> 395
      <211> 4058
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (72)..(3062)

      <400> 395
 aaattgtaaa ccagttgaat gctctgagca gcttagatga agatcaagat gactgcataa     60

 agcaagcaaa t atg cgt tca gct aaa tca gcc agt tcc tct gaa gag ctt     110
              Met Arg Ser Ala Lys Ser Ala Ser Ser Ser Glu Glu Leu
                1               5                  10

 atc aac aaa ctt aac ttt ttg gat gaa gca gaa aag gac ttg gcc acc      158
 Ile Asn Lys Leu Asn Phe Leu Asp Glu Ala Glu Lys Asp Leu Ala Thr
      15                  20                  25

 gtg aat tca aat cca ttt gat gat cct gat gct gca gaa tta aat cca      206
 Val Asn Ser Asn Pro Phe Asp Asp Pro Asp Ala Ala Glu Leu Asn Pro
  30                  35                  40                  45

 ttt gga gat cct gac tca gaa gaa cct atc act gaa aca gct tca cct      254
 Phe Gly Asp Pro Asp Ser Glu Glu Pro Ile Thr Glu Thr Ala Ser Pro
                  50                  55                  60

 aga aaa aca gaa gac tct ttt tat aat aac agc tat aat ccc ttt aaa      302
 Arg Lys Thr Glu Asp Ser Phe Tyr Asn Asn Ser Tyr Asn Pro Phe Lys
              65                  70                  75

 gag gtg cag act cca cag tat ttg aac cca ttc gat gag cca gaa gca      350
 Glu Val Gln Thr Pro Gln Tyr Leu Asn Pro Phe Asp Glu Pro Glu Ala
          80                  85                  90

 ttt gtg acc ata aag gat tct cct ccc cag tct aca aaa aga aaa aat      398
 Phe Val Thr Ile Lys Asp Ser Pro Pro Gln Ser Thr Lys Arg Lys Asn
      95                 100                 105

 ata aga cct gtg gat atg agc aag tac ctc tat gct gat agt tct aaa      446
 Ile Arg Pro Val Asp Met Ser Lys Tyr Leu Tyr Ala Asp Ser Ser Lys
 110                 115                 120                 125

 act gaa gaa gaa gaa ttg gat gaa tca aat cct ttt tat gaa cct aaa      494
 Thr Glu Glu Glu Glu Leu Asp Glu Ser Asn Pro Phe Tyr Glu Pro Lys
                 130                 135                 140

 tca act cct cct cca aat aat ttg gta aat cct gtt caa gaa cta gaa      542
 Ser Thr Pro Pro Pro Asn Asn Leu Val Asn Pro Val Gln Glu Leu Glu
             145                 150                 155

 act gaa agg cga gtg aaa aga aag gcc ccg gct cca cca gtc ctc tca      590
 Thr Glu Arg Arg Val Lys Arg Lys Ala Pro Ala Pro Pro Val Leu Ser
         160                 165                 170

 cca aaa aca gga gta tta aat gaa aac aca gtt tct gca gga aaa gat      638
 Pro Lys Thr Gly Val Leu Asn Glu Asn Thr Val Ser Ala Gly Lys Asp
     175                 180                 185

 ctc tct act tct cct aag cca agc cct ata cca agt cct gtt ttg ggg      686
 Leu Ser Thr Ser Pro Lys Pro Ser Pro Ile Pro Ser Pro Val Leu Gly
 190                 195                 200                 205

 cga aag cca aat gct agt cag tct ttg ctt gta tgg tgt aaa gaa gtt      734
 Arg Lys Pro Asn Ala Ser Gln Ser Leu Leu Val Trp Cys Lys Glu Val
                 210                 215                 220

 aca aag aac tac cga gga gta aaa atc acc aat ttt act aca tcg tgg      782
 Thr Lys Asn Tyr Arg Gly Val Lys Ile Thr Asn Phe Thr Thr Ser Trp
             225                 230                 235

 aga aat ggt tta tct ttt tgt gca ata tta cac cac ttt aga cca gat      830
 Arg Asn Gly Leu Ser Phe Cys Ala Ile Leu His His Phe Arg Pro Asp
         240                 245                 250

 tta att gac tac aag tct ctg aat cct caa gat att aaa gag aac aac      878
 Leu Ile Asp Tyr Lys Ser Leu Asn Pro Gln Asp Ile Lys Glu Asn Asn
     255                 260                 265

 aaa aag gca tac gat gga ttt gcc agc ata gga att tcc cga tta ttg      926
 Lys Lys Ala Tyr Asp Gly Phe Ala Ser Ile Gly Ile Ser Arg Leu Leu
 270                 275                 280                 285

 gaa cct tct gat atg gta tta tta gca att cct gat aaa ctg act gtt      974
 Glu Pro Ser Asp Met Val Leu Leu Ala Ile Pro Asp Lys Leu Thr Val
                 290                 295                 300

 atg act tat ctc tat caa ata agg gca cat ttc agt ggc caa gaa cta     1022
 Met Thr Tyr Leu Tyr Gln Ile Arg Ala His Phe Ser Gly Gln Glu Leu
             305                 310                 315

 aat gtc gtt cag ata gag gaa aac agc agt aaa agc aca tat aaa gtt     1070
 Asn Val Val Gln Ile Glu Glu Asn Ser Ser Lys Ser Thr Tyr Lys Val
         320                 325                 330

 gga aac tat gaa aca gat aca aac agt tct gtt gat caa gaa aaa ttc     1118
 Gly Asn Tyr Glu Thr Asp Thr Asn Ser Ser Val Asp Gln Glu Lys Phe
     335                 340                 345

 tat gca gag ctt agt gat ctg aag cgg gag cct gaa cta caa cag cct     1166
 Tyr Ala Glu Leu Ser Asp Leu Lys Arg Glu Pro Glu Leu Gln Gln Pro
 350                 355                 360                 365

 atc agc gga gca gta gac ttc tta tca cag gat gac tct gta ttt gta     1214
 Ile Ser Gly Ala Val Asp Phe Leu Ser Gln Asp Asp Ser Val Phe Val
                 370                 375                 380

 aat gat agc ggg gtt gga gag tca gaa agt gag cat caa act cct gat     1262
 Asn Asp Ser Gly Val Gly Glu Ser Glu Ser Glu His Gln Thr Pro Asp
             385                 390                 395

 gat cac ctt agt cca agc aca gcc tcc cct tac tgt cgc agg act aaa     1310
 Asp His Leu Ser Pro Ser Thr Ala Ser Pro Tyr Cys Arg Arg Thr Lys
         400                 405                 410

 agt gac aca gaa ccc cag aag tct cag cag agc tct gga agg act tca     1358
 Ser Asp Thr Glu Pro Gln Lys Ser Gln Gln Ser Ser Gly Arg Thr Ser
     415                 420                 425

 gga tct gat gac cct gga ata tgt tcc aat aca gat tca acc caa gca     1406
 Gly Ser Asp Asp Pro Gly Ile Cys Ser Asn Thr Asp Ser Thr Gln Ala
 430                 435                 440                 445

 cag gtt ttg tta ggc aaa aag aga cta ttg aaa gct gag act tta gaa     1454
 Gln Val Leu Leu Gly Lys Lys Arg Leu Leu Lys Ala Glu Thr Leu Glu
                 450                 455                 460

 ttg agt gac tta tat gtt agt gat aag aag aag gat atg tct cca ccc     1502
 Leu Ser Asp Leu Tyr Val Ser Asp Lys Lys Lys Asp Met Ser Pro Pro
             465                 470                 475

 ttt att tgt gag gag aca gat gaa caa aag ctt caa act cta gac atc     1550
 Phe Ile Cys Glu Glu Thr Asp Glu Gln Lys Leu Gln Thr Leu Asp Ile
         480                 485                 490

 ggt agt aac ttg gag aaa gaa aaa tta gag aat tcc aga tcc tta gaa     1598
 Gly Ser Asn Leu Glu Lys Glu Lys Leu Glu Asn Ser Arg Ser Leu Glu
     495                 500                 505

 tgc aga tca gat cca gaa tct cct atc aaa aaa aca agt tta tct cct     1646
 Cys Arg Ser Asp Pro Glu Ser Pro Ile Lys Lys Thr Ser Leu Ser Pro
 510                 515                 520                 525

 act tct aaa ctt gga tac tca tat agt aga gat cta gac ctt gct aag     1694
 Thr Ser Lys Leu Gly Tyr Ser Tyr Ser Arg Asp Leu Asp Leu Ala Lys
                 530                 535                 540

 aaa aaa cat gct tcc ctg agg cag acg gag tct gat cca gat gct gat     1742
 Lys Lys His Ala Ser Leu Arg Gln Thr Glu Ser Asp Pro Asp Ala Asp
             545                 550                 555

 aga acc act tta aat cat gca gat cat tca tca aaa ata gtc cag cat     1790
 Arg Thr Thr Leu Asn His Ala Asp His Ser Ser Lys Ile Val Gln His
         560                 565                 570

 cga ttg tta tct aga caa gaa gaa ctt aag gaa aga gca aga gtt ctg     1838
 Arg Leu Leu Ser Arg Gln Glu Glu Leu Lys Glu Arg Ala Arg Val Leu
     575                 580                 585

 ctt gag caa gca aga aga gat gca gcc tta aag gcg ggg aat aag cac     1886
 Leu Glu Gln Ala Arg Arg Asp Ala Ala Leu Lys Ala Gly Asn Lys His
 590                 595                 600                 605

 aat acc aac aca gcc acc cca ttc tgc aac agg cag cta agt gat cag     1934
 Asn Thr Asn Thr Ala Thr Pro Phe Cys Asn Arg Gln Leu Ser Asp Gln
                 610                 615                 620

 caa gat gaa gag cga cgt cgg cag ctg aga gag aga gct cgt cag cta     1982
 Gln Asp Glu Glu Arg Arg Arg Gln Leu Arg Glu Arg Ala Arg Gln Leu
             625                 630                 635

 ata gca gaa gct cga tct gga gtg aag atg tca gaa ctt ccc agc tat     2030
 Ile Ala Glu Ala Arg Ser Gly Val Lys Met Ser Glu Leu Pro Ser Tyr
         640                 645                 650

 ggt gaa atg gct gca gaa aag ttg aaa gaa agg tca aag gca tct gga     2078
 Gly Glu Met Ala Ala Glu Lys Leu Lys Glu Arg Ser Lys Ala Ser Gly
     655                 660                 665

 gat gaa aat gat aat att gag ata gat act aac gag gag atc cct gaa     2126
 Asp Glu Asn Asp Asn Ile Glu Ile Asp Thr Asn Glu Glu Ile Pro Glu
 670                 675                 680                 685

 ggc ttt gtt gta gga ggt gga gat gaa ctt act aac tta gaa aat gac     2174
 Gly Phe Val Val Gly Gly Gly Asp Glu Leu Thr Asn Leu Glu Asn Asp
                 690                 695                 700

 ctt gat act ccc gaa caa aac agt aag ttg gtg gac ttg aag ctg aag     2222
 Leu Asp Thr Pro Glu Gln Asn Ser Lys Leu Val Asp Leu Lys Leu Lys
             705                 710                 715

 aag ctc cta gaa gtt cag cca cag gtg gca aat tca ccc tcc agt gct     2270
 Lys Leu Leu Glu Val Gln Pro Gln Val Ala Asn Ser Pro Ser Ser Ala
         720                 725                 730

 gcc cag aaa gct gta act gag agc tca gag cag gac atg aaa agt ggc     2318
 Ala Gln Lys Ala Val Thr Glu Ser Ser Glu Gln Asp Met Lys Ser Gly
     735                 740                 745

 aca gaa gat ctc cgg act gaa cga tta caa aaa aca aca gaa cgt ttt     2366
 Thr Glu Asp Leu Arg Thr Glu Arg Leu Gln Lys Thr Thr Glu Arg Phe
 750                 755                 760                 765

 aga aat cct gtt gtg ttc agc aaa gat tct aca gtc aga aaa act caa     2414
 Arg Asn Pro Val Val Phe Ser Lys Asp Ser Thr Val Arg Lys Thr Gln
                 770                 775                 780

 ctt cag tct ttc agc caa tat att gag aat aga cca gag atg aaa agg     2462
 Leu Gln Ser Phe Ser Gln Tyr Ile Glu Asn Arg Pro Glu Met Lys Arg
             785                 790                 795

 cag aga tca ata cag gaa gat aca aag aaa gga aat gag gag aag gca     2510
 Gln Arg Ser Ile Gln Glu Asp Thr Lys Lys Gly Asn Glu Glu Lys Ala
         800                 805                 810

 gcg ata act gaa act cag agg aag cca tca gaa gat gaa gtg ctt aat     2558
 Ala Ile Thr Glu Thr Gln Arg Lys Pro Ser Glu Asp Glu Val Leu Asn
     815                 820                 825

 aaa ggg ttc aaa gac acc agt cag tat gta gta gga gaa ttg gca gca     2606
 Lys Gly Phe Lys Asp Thr Ser Gln Tyr Val Val Gly Glu Leu Ala Ala
 830                 835                 840                 845

 cta gag aat gag caa aag caa att gac acc cgt gcc gcg ctg gtg gag     2654
 Leu Glu Asn Glu Gln Lys Gln Ile Asp Thr Arg Ala Ala Leu Val Glu
                 850                 855                 860

 aag cgc ctt cgc tat ctc atg gac aca gga agg aac aca gaa gaa gaa     2702
 Lys Arg Leu Arg Tyr Leu Met Asp Thr Gly Arg Asn Thr Glu Glu Glu
             865                 870                 875

 gaa gct atg atg cag gaa tgg ttt atg tta gtt aat aag aaa aat gcc     2750
 Glu Ala Met Met Gln Glu Trp Phe Met Leu Val Asn Lys Lys Asn Ala
         880                 885                 890

 tta ata agg aga atg aat cag ctc tct ctt ctg gaa aaa gaa cat gat     2798
 Leu Ile Arg Arg Met Asn Gln Leu Ser Leu Leu Glu Lys Glu His Asp
     895                 900                 905

 tta gaa cga cgg tat gag ctg ctg aac cgg gaa ttg agg gca atg cta     2846
 Leu Glu Arg Arg Tyr Glu Leu Leu Asn Arg Glu Leu Arg Ala Met Leu
 910                 915                 920                 925

 gcc att gaa gac tgg cag aag acc gag gcc cag aag cga cgc gaa cag     2894
 Ala Ile Glu Asp Trp Gln Lys Thr Glu Ala Gln Lys Arg Arg Glu Gln
                 930                 935                 940

 ctt ctg cta gat gag ctg gtg gcc ctg gtg aac aag cgc gat gcg ctc     2942
 Leu Leu Leu Asp Glu Leu Val Ala Leu Val Asn Lys Arg Asp Ala Leu
             945                 950                 955

 gtc agg gac ctg gac gcg cag gag aag cag gcc gaa gaa gaa gat gag     2990
 Val Arg Asp Leu Asp Ala Gln Glu Lys Gln Ala Glu Glu Glu Asp Glu
         960                 965                 970

 cat ttg gag cga act ctg gag caa aac aaa ggc aag atg gcc aag aaa     3038
 His Leu Glu Arg Thr Leu Glu Gln Asn Lys Gly Lys Met Ala Lys Lys
     975                 980                 985

 gag gag aaa tgt gtt ctt cag tag ccatcagatc agaaagaatc tctcccaaca    3092
 Glu Glu Lys Cys Val Leu Gln 
 990                 995

 ttttagagtc ttgcttccca aaccagaaaa agtcagactc attgttgatt taaaactttt   3152

 aacattttgt ttggctggat tgtactactt tacctctact ttaccaccac cacccttttc   3212

 ctccctcctt tccaaataat atacagaact ccaaaatagc ttcatttaag gatttttttg   3272

 tgagttaaca atttccttga aatcctgtga aatagatttg cacagacacc ttgtgagtga   3332

 ttggtattgg aggtgttcaa gaaactgttc gaaaaagaac aaaaacactt ccctcgttat   3392

 tttctctcat tttttgatga gaggaaaatt tgaaacatta ttcttgttgt tgttggtaat   3452

 agcataatga cagtgggagg ggtacaaggg gataagaaaa atgtcatgat ttttttccgg   3512

 tcctgccaca tgtaacactt actctgttac ctaaatttta tagttagatc atatccaatc   3572

 tacttattaa actgtgttct atttaccagt ggagtttttc tgcagtggtt gcgtttcact   3632

 gtaaggataa tggagttcct ctcctctgct ttcctcagag gatggtcctt taacatagcc   3692

 agaaacaagc cctgtggttt gaaggtgagc tgtgaggatg ggactaattg atatgcacca   3752

 gtttacaaag acagtcttat catccgagaa tacaccatct ttttctctgg ataattattt   3812

 cttacatcat gcttgattcc tacattttgt tgggtctcaa cattggctca cgaatgctgt   3872

 taatatttat tctgtattga taaaaagtct gtcttgccac tacaagtaaa tcccccattt   3932

 aatattttct tctttagcat agcactgtca ttttttgtga aaatggttat gtttatttat   3992

 tacaatactg agtcatatat aaattttcaa taaaagcaga aactttctta ccttaaaaaa   4052

 aaaaaa                                                              4058




      <210> 396
      <211> 3950
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (72)..(2954)

      <400> 396
 aaattgtaaa ccagttgaat gctctgagca gcttagatga agatcaagat gactgcataa     60

 agcaagcaaa t atg cgt tca gct aaa tca gcc agt tcc tct gaa gag ctt     110
              Met Arg Ser Ala Lys Ser Ala Ser Ser Ser Glu Glu Leu
                1               5                  10

 atc aac aaa ctt aac ttt ttg gat gaa gca gaa aag gac ttg gcc acc      158
 Ile Asn Lys Leu Asn Phe Leu Asp Glu Ala Glu Lys Asp Leu Ala Thr
      15                  20                  25

 gtg aat tca aat cca ttt gat gat cct gat gct gca gaa tta aat cca      206
 Val Asn Ser Asn Pro Phe Asp Asp Pro Asp Ala Ala Glu Leu Asn Pro
  30                  35                  40                  45

 ttt gga gat cct gac tca gaa gaa cct atc act gaa aca gct tca cct      254
 Phe Gly Asp Pro Asp Ser Glu Glu Pro Ile Thr Glu Thr Ala Ser Pro
                  50                  55                  60

 aga aaa aca gaa gac tct ttt tat aat aac agc tat aat ccc ttt aaa      302
 Arg Lys Thr Glu Asp Ser Phe Tyr Asn Asn Ser Tyr Asn Pro Phe Lys
              65                  70                  75

 gag gtg cag act cca cag tat ttg aac cca ttc gat gag cca gaa gca      350
 Glu Val Gln Thr Pro Gln Tyr Leu Asn Pro Phe Asp Glu Pro Glu Ala
          80                  85                  90

 ttt gtg acc ata aag gat tct cct ccc cag tct aca aaa aga aaa aat      398
 Phe Val Thr Ile Lys Asp Ser Pro Pro Gln Ser Thr Lys Arg Lys Asn
      95                 100                 105

 ata aga cct gtg gat atg agc aag tac ctc tat gct gat agt tct aaa      446
 Ile Arg Pro Val Asp Met Ser Lys Tyr Leu Tyr Ala Asp Ser Ser Lys
 110                 115                 120                 125

 act gaa gaa gaa gaa ttg gat gaa tca aat cct ttt tat gaa cct aaa      494
 Thr Glu Glu Glu Glu Leu Asp Glu Ser Asn Pro Phe Tyr Glu Pro Lys
                 130                 135                 140

 tca act cct cct cca aat aat ttg gta aat cct gtt caa gaa cta gaa      542
 Ser Thr Pro Pro Pro Asn Asn Leu Val Asn Pro Val Gln Glu Leu Glu
             145                 150                 155

 act gaa agg cga gtg aaa aga aag gcc ccg gct cca cca gtc ctc tca      590
 Thr Glu Arg Arg Val Lys Arg Lys Ala Pro Ala Pro Pro Val Leu Ser
         160                 165                 170

 cca aaa aca gga gta tta aat gaa aac aca gtt tct gca gga aaa gat      638
 Pro Lys Thr Gly Val Leu Asn Glu Asn Thr Val Ser Ala Gly Lys Asp
     175                 180                 185

 ctc tct act tct cct aag cca agc cct ata cca agt cct gtt ttg ggg      686
 Leu Ser Thr Ser Pro Lys Pro Ser Pro Ile Pro Ser Pro Val Leu Gly
 190                 195                 200                 205

 cga aag cca aat gct agt cag tct ttg ctt gta tgg tgt aaa gaa gtt      734
 Arg Lys Pro Asn Ala Ser Gln Ser Leu Leu Val Trp Cys Lys Glu Val
                 210                 215                 220

 aca aag aac tac cga gga gta aaa atc acc aat ttt act aca tcg tgg      782
 Thr Lys Asn Tyr Arg Gly Val Lys Ile Thr Asn Phe Thr Thr Ser Trp
             225                 230                 235

 aga aat ggt tta tct ttt tgt gca ata tta cac cac ttt aga cca gat      830
 Arg Asn Gly Leu Ser Phe Cys Ala Ile Leu His His Phe Arg Pro Asp
         240                 245                 250

 tta att gac tac aag tct ctg aat cct caa gat att aaa gag aac aac      878
 Leu Ile Asp Tyr Lys Ser Leu Asn Pro Gln Asp Ile Lys Glu Asn Asn
     255                 260                 265

 aaa aag gca tac gat gga ttt gcc agc ata gga att tcc cga tta ttg      926
 Lys Lys Ala Tyr Asp Gly Phe Ala Ser Ile Gly Ile Ser Arg Leu Leu
 270                 275                 280                 285

 gaa cct tct gat atg gta tta tta gca att cct gat aaa ctg act gtt      974
 Glu Pro Ser Asp Met Val Leu Leu Ala Ile Pro Asp Lys Leu Thr Val
                 290                 295                 300

 atg act tat ctc tat caa ata agg gca cat ttc agt ggc caa gaa cta     1022
 Met Thr Tyr Leu Tyr Gln Ile Arg Ala His Phe Ser Gly Gln Glu Leu
             305                 310                 315

 aat gtc gtt cag ata gag gaa aac agc agt aaa agc aca tat aaa gtt     1070
 Asn Val Val Gln Ile Glu Glu Asn Ser Ser Lys Ser Thr Tyr Lys Val
         320                 325                 330

 gga aac tat gaa aca gat aca aac agt tct gtt gat caa gaa aaa ttc     1118
 Gly Asn Tyr Glu Thr Asp Thr Asn Ser Ser Val Asp Gln Glu Lys Phe
     335                 340                 345

 tat gca gag ctt agt gat ctg aag cgg gag cct gaa cta caa cag cct     1166
 Tyr Ala Glu Leu Ser Asp Leu Lys Arg Glu Pro Glu Leu Gln Gln Pro
 350                 355                 360                 365

 atc agc gga gca gta gac ttc tta tca cag gat gac tct gta ttt gta     1214
 Ile Ser Gly Ala Val Asp Phe Leu Ser Gln Asp Asp Ser Val Phe Val
                 370                 375                 380

 aat gat agc ggg gtt gga gag tca gaa agt gag cat caa act cct gat     1262
 Asn Asp Ser Gly Val Gly Glu Ser Glu Ser Glu His Gln Thr Pro Asp
             385                 390                 395

 gat cac ctt agt cca agc aca gcc tcc cct tac tgt cgc agg act aaa     1310
 Asp His Leu Ser Pro Ser Thr Ala Ser Pro Tyr Cys Arg Arg Thr Lys
         400                 405                 410

 agt gac aca gaa ccc cag aag tct cag cag agc tct gga agg act tca     1358
 Ser Asp Thr Glu Pro Gln Lys Ser Gln Gln Ser Ser Gly Arg Thr Ser
     415                 420                 425

 gga tct gat gac cct gga ata tgt tcc aat aca gat tca acc caa gca     1406
 Gly Ser Asp Asp Pro Gly Ile Cys Ser Asn Thr Asp Ser Thr Gln Ala
 430                 435                 440                 445

 cag gtt ttg tta ggc aaa aag aga cta ttg aaa gct gag act tta gaa     1454
 Gln Val Leu Leu Gly Lys Lys Arg Leu Leu Lys Ala Glu Thr Leu Glu
                 450                 455                 460

 ttg agt gac tta tat gtt agt gat aag aag aag gat atg tct cca ccc     1502
 Leu Ser Asp Leu Tyr Val Ser Asp Lys Lys Lys Asp Met Ser Pro Pro
             465                 470                 475

 ttt att tgt gag gag aca gat gaa caa aag ctt caa act cta gac atc     1550
 Phe Ile Cys Glu Glu Thr Asp Glu Gln Lys Leu Gln Thr Leu Asp Ile
         480                 485                 490

 ggt agt aac ttg gag aaa gaa aaa tta gag aat tcc aga tcc tta gaa     1598
 Gly Ser Asn Leu Glu Lys Glu Lys Leu Glu Asn Ser Arg Ser Leu Glu
     495                 500                 505

 tgc aga tca gat cca gaa tct cct atc aaa aaa aca agt tta tct cct     1646
 Cys Arg Ser Asp Pro Glu Ser Pro Ile Lys Lys Thr Ser Leu Ser Pro
 510                 515                 520                 525

 act tct aaa ctt gga tac tca tat agt aga gat cta gac ctt gct aag     1694
 Thr Ser Lys Leu Gly Tyr Ser Tyr Ser Arg Asp Leu Asp Leu Ala Lys
                 530                 535                 540

 aaa aaa cat gct tcc ctg agg cag acg gag tct gat cca gat gct gat     1742
 Lys Lys His Ala Ser Leu Arg Gln Thr Glu Ser Asp Pro Asp Ala Asp
             545                 550                 555

 aga acc act tta aat cat gca gat cat tca tca aaa ata gtc cag cat     1790
 Arg Thr Thr Leu Asn His Ala Asp His Ser Ser Lys Ile Val Gln His
         560                 565                 570

 cga ttg tta tct aga caa gaa gaa ctt aag gaa aga gca aga gtt ctg     1838
 Arg Leu Leu Ser Arg Gln Glu Glu Leu Lys Glu Arg Ala Arg Val Leu
     575                 580                 585

 ctt gag caa gca aga aga gat gca gcc tta aag gcg ggg aat aag cac     1886
 Leu Glu Gln Ala Arg Arg Asp Ala Ala Leu Lys Ala Gly Asn Lys His
 590                 595                 600                 605

 aat acc aac aca gcc acc cca ttc tgc aac agg cag cta agt gat cag     1934
 Asn Thr Asn Thr Ala Thr Pro Phe Cys Asn Arg Gln Leu Ser Asp Gln
                 610                 615                 620

 caa gat gaa gag cga cgt cgg cag ctg aga gag aga gct cgt cag cta     1982
 Gln Asp Glu Glu Arg Arg Arg Gln Leu Arg Glu Arg Ala Arg Gln Leu
             625                 630                 635

 ata gca gaa gct cga tct gga gtg aag atg tca gaa ctt ccc agc tat     2030
 Ile Ala Glu Ala Arg Ser Gly Val Lys Met Ser Glu Leu Pro Ser Tyr
         640                 645                 650

 ggt gaa atg gct gca gaa aag ttg aaa gaa agg tca aag gca tct gga     2078
 Gly Glu Met Ala Ala Glu Lys Leu Lys Glu Arg Ser Lys Ala Ser Gly
     655                 660                 665

 gaa caa aac agt aag ttg gtg gac ttg aag ctg aag aag ctc cta gaa     2126
 Glu Gln Asn Ser Lys Leu Val Asp Leu Lys Leu Lys Lys Leu Leu Glu
 670                 675                 680                 685

 gtt cag cca cag gtg gca aat tca ccc tcc agt gct gcc cag aaa gct     2174
 Val Gln Pro Gln Val Ala Asn Ser Pro Ser Ser Ala Ala Gln Lys Ala
                 690                 695                 700

 gta act gag agc tca gag cag gac atg aaa agt ggc aca gaa gat ctc     2222
 Val Thr Glu Ser Ser Glu Gln Asp Met Lys Ser Gly Thr Glu Asp Leu
             705                 710                 715

 cgg act gaa cga tta caa aaa aca aca gaa cgt ttt aga aat cct gtt     2270
 Arg Thr Glu Arg Leu Gln Lys Thr Thr Glu Arg Phe Arg Asn Pro Val
         720                 725                 730

 gtg ttc agc aaa gat tct aca gtc aga aaa act caa ctt cag tct ttc     2318
 Val Phe Ser Lys Asp Ser Thr Val Arg Lys Thr Gln Leu Gln Ser Phe
     735                 740                 745

 agc caa tat att gag aat aga cca gag atg aaa agg cag aga tca ata     2366
 Ser Gln Tyr Ile Glu Asn Arg Pro Glu Met Lys Arg Gln Arg Ser Ile
 750                 755                 760                 765

 cag gaa gat aca aag aaa gga aat gag gag aag gca gcg ata act gaa     2414
 Gln Glu Asp Thr Lys Lys Gly Asn Glu Glu Lys Ala Ala Ile Thr Glu
                 770                 775                 780

 act cag agg aag cca tca gaa gat gaa gtg ctt aat aaa ggg ttc aaa     2462
 Thr Gln Arg Lys Pro Ser Glu Asp Glu Val Leu Asn Lys Gly Phe Lys
             785                 790                 795

 gac acc agt cag tat gta gta gga gaa ttg gca gca cta gag aat gag     2510
 Asp Thr Ser Gln Tyr Val Val Gly Glu Leu Ala Ala Leu Glu Asn Glu
         800                 805                 810

 caa aag caa att gac acc cgt gcc gcg ctg gtg gag aag cgc ctt cgc     2558
 Gln Lys Gln Ile Asp Thr Arg Ala Ala Leu Val Glu Lys Arg Leu Arg
     815                 820                 825

 tat ctc atg gac aca gga agg aac aca gaa gaa gaa gaa gct atg atg     2606
 Tyr Leu Met Asp Thr Gly Arg Asn Thr Glu Glu Glu Glu Ala Met Met
 830                 835                 840                 845

 cag gaa tgg ttt atg tta gtt aat aag aaa aat gcc tta ata agg aga     2654
 Gln Glu Trp Phe Met Leu Val Asn Lys Lys Asn Ala Leu Ile Arg Arg
                 850                 855                 860

 atg aat cag ctc tct ctt ctg gaa aaa gaa cat gat tta gaa cga cgg     2702
 Met Asn Gln Leu Ser Leu Leu Glu Lys Glu His Asp Leu Glu Arg Arg
             865                 870                 875

 tat gag ctg ctg aac cgg gaa ttg agg gca atg cta gcc att gaa gac     2750
 Tyr Glu Leu Leu Asn Arg Glu Leu Arg Ala Met Leu Ala Ile Glu Asp
         880                 885                 890

 tgg cag aag acc gag gcc cag aag cga cgc gaa cag ctt ctg cta gat     2798
 Trp Gln Lys Thr Glu Ala Gln Lys Arg Arg Glu Gln Leu Leu Leu Asp
     895                 900                 905

 gag ctg gtg gcc ctg gtg aac aag cgc gat gcg ctc gtc agg gac ctg     2846
 Glu Leu Val Ala Leu Val Asn Lys Arg Asp Ala Leu Val Arg Asp Leu
 910                 915                 920                 925

 gac gcg cag gag aag cag gcc gaa gaa gaa gat gag cat ttg gag cga     2894
 Asp Ala Gln Glu Lys Gln Ala Glu Glu Glu Asp Glu His Leu Glu Arg
                 930                 935                 940

 act ctg gag caa aac aaa ggc aag atg gcc aag aaa gag gag aaa tgt     2942
 Thr Leu Glu Gln Asn Lys Gly Lys Met Ala Lys Lys Glu Glu Lys Cys
             945                 950                 955

 gtt ctt cag tag cca tcagatcaga aagaatctct cccaacattt tagagtcttg     2997
 Val Leu Gln 
         960

 cttcccaaac cagaaaaagt cagactcatt gttgatttaa aacttttaac attttgtttg   3057

 gctggattgt actactttac ctctacttta ccaccaccac ccttttcctc cctcctttcc   3117

 aaataatata cagaactcca aaatagcttc atttaaggat ttttttgtga gttaacaatt   3177

 tccttgaaat cctgtgaaat agatttgcac agacaccttg tgagtgattg gtattggagg   3237

 tgttcaagaa actgttcgaa aaagaacaaa aacacttccc tcgttatttt ctctcatttt   3297

 ttgatgagag gaaaatttga aacattattc ttgttgttgt tggtaatagc ataatgacag   3357

 tgggaggggt acaaggggat aagaaaaatg tcatgatttt tttccggtcc tgccacatgt   3417

 aacacttact ctgttaccta aattttatag ttagatcata tccaatctac ttattaaact   3477

 gtgttctatt taccagtgga gtttttctgc agtggttgcg tttcactgta aggataatgg   3537

 agttcctctc ctctgctttc ctcagaggat ggtcctttaa catagccaga aacaagccct   3597

 gtggtttgaa ggtgagctgt gaggatggga ctaattgata tgcaccagtt tacaaagaca   3657

 gtcttatcat ccgagaatac accatctttt tctctggata attatttctt acatcatgct   3717

 tgattcctac attttgttgg gtctcaacat tggctcacga atgctgttaa tatttattct   3777

 gtattgataa aaagtctgtc ttgccactac aagtaaatcc cccatttaat attttcttct   3837

 ttagcatagc actgtcattt tttgtgaaaa tggttatgtt tatttattac aatactgagt   3897

 catatataaa ttttcaataa aagcagaaac tttcttacct taaaaaaaaa aaa          3950




      <210> 397
      <211> 1867
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (111)..(1583)

      <400> 397
 ggtcacttta aggagggctg tccaactgca aggagccgca agcaggaagt gaaaccacag     60

 cacttcaaaa aaagagggag actgggacaa gcgtatctaa gaggctgaac   atg aat     116
                                                          Met Asn
                                                            1

 cca cag atc aga aat ccg atg gag cgg atg tat cga gac aca ttc tac      164
 Pro Gln Ile Arg Asn Pro Met Glu Arg Met Tyr Arg Asp Thr Phe Tyr
           5                  10                  15

 gac aac ttt gaa aac gaa ccc atc ctc tat ggt cgg agc tac act tgg      212
 Asp Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr Thr Trp
      20                  25                  30

 ctg tgc tat gaa gtg aaa ata aag agg ggc cgc tca aat ctc ctt tgg      260
 Leu Cys Tyr Glu Val Lys Ile Lys Arg Gly Arg Ser Asn Leu Leu Trp
  35                  40                  45                  50

 gac aca ggg gtc ttt cga ggc cag gtg tat ttc gag cct cag tac cac      308
 Asp Thr Gly Val Phe Arg Gly Gln Val Tyr Phe Glu Pro Gln Tyr His
                  55                  60                  65

 gca gaa atg tgc ttc ctc tct tgg ttc tgt ggc aac cag ctg cct gct      356
 Ala Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu Pro Ala
              70                  75                  80

 tac aag tgt ttc cag atc acc tgg ttt gta tcc tgg acc ccc tgc ctg      404
 Tyr Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr Pro Cys Leu
          85                  90                  95

 gac tgt gtg gcg aag ctg gcc gaa ttc ctg tct gag cac ccc aat gtc      452
 Asp Cys Val Ala Lys Leu Ala Glu Phe Leu Ser Glu His Pro Asn Val
     100                 105                 110

 acc ctg acc atc tct gcc gcc cgc ctc tac tac tac tgg gaa aga gat      500
 Thr Leu Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu Arg Asp
 115                 120                 125                 130

 tac cga agg gcg ctc tgc agg ctg agt cag gca gga gcc cgc gtg acg      548
 Tyr Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg Val Thr
                 135                 140                 145

 atc atg gac tat gaa gaa ttt gca tac tgc tgg gaa aac ttt gtg tac      596
 Ile Met Asp Tyr Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe Val Tyr
             150                 155                 160

 aat gaa ggt cag caa ttc atg cct tgg tac aaa ttc gat gaa aat tat      644
 Asn Glu Gly Gln Gln Phe Met Pro Trp Tyr Lys Phe Asp Glu Asn Tyr
         165                 170                 175

 gca ttc ctg cac cgc acg cta aag gag att ctc aga tac ctg atg gat      692
 Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu Arg Tyr Leu Met Asp
     180                 185                 190

 cca gac aca ttc act ttc aac ttt aat aat gac cct ttg gtc ctt cga      740
 Pro Asp Thr Phe Thr Phe Asn Phe Asn Asn Asp Pro Leu Val Leu Arg
 195                 200                 205                 210

 cgg cgc cag acc tac ttg tgc tat gag gtg gag cgc ctg gac aat ggc      788
 Arg Arg Gln Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly
                 215                 220                 225

 acc tgg gtc ctg atg gac cag cac atg ggc ttt cta tgc aac gag gct      836
 Thr Trp Val Leu Met Asp Gln His Met Gly Phe Leu Cys Asn Glu Ala
             230                 235                 240

 aag aat ctt ctc tgt ggc ttt tac ggc cgc cat gcg gag ctg cgc ttc      884
 Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe
         245                 250                 255

 ttg gac ctg gtt cct tct ttg cag ttg gac ccg gcc cag atc tac agg      932
 Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg
     260                 265                 270

 gtc act tgg ttc atc tcc tgg agc ccc tgc ttc tcc tgg ggc tgt gcc      980
 Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala
 275                 280                 285                 290

 ggg gaa gtg cgt gcg ttc ctt cag gag aac aca cac gtg aga ctg cgc     1028
 Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg
                 295                 300                 305

 atc ttc gct gcc cgc atc tat gat tac gac ccc cta tat aag gag gcg     1076
 Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala
             310                 315                 320

 ctg caa atg ctg cgg gat gct ggg gcc caa gtc tcc atc atg acc tac     1124
 Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr
         325                 330                 335

 gat gag ttt gag tac tgc tgg gac acc ttt gtg tac cgc cag gga tgt     1172
 Asp Glu Phe Glu Tyr Cys Trp Asp Thr Phe Val Tyr Arg Gln Gly Cys
     340                 345                 350

 ccc ttc cag ccc tgg gat gga cta gag gag cac agc caa gcc ctg agt     1220
 Pro Phe Gln Pro Trp Asp Gly Leu Glu Glu His Ser Gln Ala Leu Ser
 355                 360                 365                 370

 ggg agg ctg cgg gcc att ctc cag gtg agg gct tcc tcc ctc tgc ctg     1268
 Gly Arg Leu Arg Ala Ile Leu Gln Val Arg Ala Ser Ser Leu Cys Leu
                 375                 380                 385

 gtg ccc cat cgg cct ccc cct cct ccc cgc tcc cct gtg cct tgc ctt     1316
 Val Pro His Arg Pro Pro Pro Pro Pro Arg Ser Pro Val Pro Cys Leu
             390                 395                 400

 ccc ctc tgc tca gag cct cct ctg ggt tcc ctg ctc ccc aca ggg cgc     1364
 Pro Leu Cys Ser Glu Pro Pro Leu Gly Ser Leu Leu Pro Thr Gly Arg
         405                 410                 415

 cca gct ccg tcc ctc cct ttc ctt ctc aca gcc tcc ttc tct ttc cca     1412
 Pro Ala Pro Ser Leu Pro Phe Leu Leu Thr Ala Ser Phe Ser Phe Pro
     420                 425                 430

 cct ccc gca tcc ctc cct cct ctc ccg tca ttg tca ctg tcc cca ggc     1460
 Pro Pro Ala Ser Leu Pro Pro Leu Pro Ser Leu Ser Leu Ser Pro Gly
 435                 440                 445                 450

 cac ctc cct gtg ccc tct ttc cac tct ctc acc tcc tgc tcc att caa     1508
 His Leu Pro Val Pro Ser Phe His Ser Leu Thr Ser Cys Ser Ile Gln
                 455                 460                 465

 ccc ccc tgc tct tcc aga atc agg gaa act gaa gga tgg gcc tca gtc     1556
 Pro Pro Cys Ser Ser Arg Ile Arg Glu Thr Glu Gly Trp Ala Ser Val
             470                 475                 480

 tct aag gaa ggc aga gac ctg ggt tga gcagc agaataaaag atcttcttcc     1608
 Ser Lys Glu Gly Arg Asp Leu Gly 
         485                 490

 aagaaatgca aacagaccgt tcaccaccat ctccagctgc tcacagacac cagcaaagca   1668

 atgtgctcct gatcaagtag atttttttaa aaatcagagt caattaattt taattgaaaa   1728

 tttctcttat gttccaagtg tacaagagta agattatgct caatattccc agaatagttt   1788

 tcaatgtatt aatgaagtga ttaattggct ccatatttag actaataaaa cattaagaat   1848

 cttccaaaaa aaaaaaaaa                                                1867




      <210> 398
      <211> 1719
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (397)..(1665)

      <400> 398
 ggggaccagg gaccggggag ggcgagaacg gagagtcagg ccgggcgagg catggaccga     60

 aggcggctcc gggagtgtgg gcccccctgg gacgtgtgcg tgtttccggg ggctcctgca    120

 aatgctcgtg cgtgtgcatt tgcacgtgga ctcggtcagg cgtgtgcaga cagcgcctgc    180

 aggtctgggt gggtgctgat ctgagtgtct gcgcctgggc catgtttttg agcctggcac    240

 aggggtgctt agtgaacaca tgaccgccta gcgttgtgtg ccggatccaa cggggaatga    300

 aactagagta ggacatgctc ccaacccttt tagaagcggg cccaggatgc tgtgatcatc    360

 ctggggggag gaggacttct cttcgcctcc tacctg  atg gcc acg gga gat gag     414
                                          Met Ala Thr Gly Asp Glu
                                            1               5

 cgt ttc tat gct gaa cac ctg atg ccg act ctg cag ggg ctg ctg gac      462
 Arg Phe Tyr Ala Glu His Leu Met Pro Thr Leu Gln Gly Leu Leu Asp
              10                  15                  20

 ccg gag tca gcc cac aga ctg gct gtt cgc ttc acc tcc ctg ggg ctc      510
 Pro Glu Ser Ala His Arg Leu Ala Val Arg Phe Thr Ser Leu Gly Leu
          25                  30                  35

 ctt cca cgg gcc aga ttt caa gac tct gac atg ctg gta gtg ctc cca      558
 Leu Pro Arg Ala Arg Phe Gln Asp Ser Asp Met Leu Val Val Leu Pro
      40                  45                  50

 gac acc cta tac att aaa tac aaa ggc gaa ggc tgc agt ccc cta aac      606
 Asp Thr Leu Tyr Ile Lys Tyr Lys Gly Glu Gly Cys Ser Pro Leu Asn
  55                  60                  65                  70

 ttc tca gct ggg act gat ctt ttt gaa aac cag aac ccc aag atc cga      654
 Phe Ser Ala Gly Thr Asp Leu Phe Glu Asn Gln Asn Pro Lys Ile Arg
                  75                  80                  85

 ccg tgt tca ccc cgg gag gcc ttt gct agt ctc ctg aaa ggt cgc tgg      702
 Pro Cys Ser Pro Arg Glu Ala Phe Ala Ser Leu Leu Lys Gly Arg Trp
              90                  95                 100

 agc cca tca gaa gtg aga gtt ctg ggc cat aaa ttc cga aat cca gta      750
 Ser Pro Ser Glu Val Arg Val Leu Gly His Lys Phe Arg Asn Pro Val
         105                 110                 115

 gga att gct gca gga ttt gac aag cat ggg gaa gcc gtg gac gga ctt      798
 Gly Ile Ala Ala Gly Phe Asp Lys His Gly Glu Ala Val Asp Gly Leu
     120                 125                 130

 tat aag atg ggc ttt ggt ttt gtt gag ata gga agt gtg act cca aaa      846
 Tyr Lys Met Gly Phe Gly Phe Val Glu Ile Gly Ser Val Thr Pro Lys
 135                 140                 145                 150

 cct cag gaa gga aac cct aga ccc aga gtc ttc cgc ctc cct gag gac      894
 Pro Gln Glu Gly Asn Pro Arg Pro Arg Val Phe Arg Leu Pro Glu Asp
                 155                 160                 165

 caa gct gtc att aac agg tat gga ttt aac agt cac ggg ctt tca gtg      942
 Gln Ala Val Ile Asn Arg Tyr Gly Phe Asn Ser His Gly Leu Ser Val
             170                 175                 180

 gtg gaa cac agg tta cgg gcc aga cag cag aag cag gcc aag ctc aca      990
 Val Glu His Arg Leu Arg Ala Arg Gln Gln Lys Gln Ala Lys Leu Thr
         185                 190                 195

 gaa gat gga ctg cct ctg ggg gtc aac ttg ggg aag aac aag acc tca     1038
 Glu Asp Gly Leu Pro Leu Gly Val Asn Leu Gly Lys Asn Lys Thr Ser
     200                 205                 210

 gtg gac gcc gcg gag gac tac gca gaa ggg gtg cgc gta ctg ggc ccc     1086
 Val Asp Ala Ala Glu Asp Tyr Ala Glu Gly Val Arg Val Leu Gly Pro
 215                 220                 225                 230

 ctg gcc gac tac ctg gtg gtg aat gtg tcc agc ccc aac act gcc ggg     1134
 Leu Ala Asp Tyr Leu Val Val Asn Val Ser Ser Pro Asn Thr Ala Gly
                 235                 240                 245

 ctg cgg agc ctt cag gga aag gcc gag ctg cgc cgc ctg ctg acc aag     1182
 Leu Arg Ser Leu Gln Gly Lys Ala Glu Leu Arg Arg Leu Leu Thr Lys
             250                 255                 260

 gtg ctg cag gag agg gat ggc ttg cgg aga gtg cac agg ccg gca gtc     1230
 Val Leu Gln Glu Arg Asp Gly Leu Arg Arg Val His Arg Pro Ala Val
         265                 270                 275

 ctg gtg aag atc gct cct gac ctc acc agc cag gat aag gag gac att     1278
 Leu Val Lys Ile Ala Pro Asp Leu Thr Ser Gln Asp Lys Glu Asp Ile
     280                 285                 290

 gcc agt gtg gtc aaa gag ttg ggc atc gat ggg ctg att gtt acg aac     1326
 Ala Ser Val Val Lys Glu Leu Gly Ile Asp Gly Leu Ile Val Thr Asn
 295                 300                 305                 310

 acc acc gtg agt cgc cct gcg ggc ctc cag ggt gcc ctg cgc tct gaa     1374
 Thr Thr Val Ser Arg Pro Ala Gly Leu Gln Gly Ala Leu Arg Ser Glu
                 315                 320                 325

 aca gga ggg ctg agt ggg aag ccc ctc cgg gat tta tca act caa acc     1422
 Thr Gly Gly Leu Ser Gly Lys Pro Leu Arg Asp Leu Ser Thr Gln Thr
             330                 335                 340

 att cgg gag atg tat gca ctc acc caa ggc cga gtt ccc ata att ggg     1470
 Ile Arg Glu Met Tyr Ala Leu Thr Gln Gly Arg Val Pro Ile Ile Gly
         345                 350                 355

 gtt ggt ggt gtg agc agc ggg cag gac gcg ctg gag aag atc cgg gca     1518
 Val Gly Gly Val Ser Ser Gly Gln Asp Ala Leu Glu Lys Ile Arg Ala
     360                 365                 370

 ggg gcc tcc ctg gtg cag ctg tac acg gcc ctc acc ttc tgg ggg cca     1566
 Gly Ala Ser Leu Val Gln Leu Tyr Thr Ala Leu Thr Phe Trp Gly Pro
 375                 380                 385                 390

 ccc gtt gtg ggc aaa gtc aag cgg gaa ctg gag gcc ctt ctg aaa gag     1614
 Pro Val Val Gly Lys Val Lys Arg Glu Leu Glu Ala Leu Leu Lys Glu
                 395                 400                 405

 cag ggc ttt ggc gga gtc aca gat gcc att gga gca gat cat cgg agg     1662
 Gln Gly Phe Gly Gly Val Thr Asp Ala Ile Gly Ala Asp His Arg Arg
             410                 415                 420

 tga ggac agcgtctgac gggaagcctg atctggaacc ttcccaagga ctcaggcaag     1719
 






      <210> 399
      <211> 1717
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (220)..(1692)

      <400> 399
 acaagatggc ggcgctgcgg gacggctagc ggccctgcgt gggagttcct gacagctgga     60

 ttctagaagt agaactatga gctcaccttt ggcctccctt agcaagaccc gaaaagtgcc    120

 cctgccctcg gagcctatga atcctgggag gcgaggaatc cgcatctatg gagatgagcg    180

 gtgacctagg catccctgtc tgcagaagat gaggtggac   atg ttg agt gat ggg     234
                                              Met Leu Ser Asp Gly
                                                1               5

 tgt ggc tcg gaa gaa aag atc tca gtc cct tcc tgc tat ggc ggc ata      282
 Cys Gly Ser Glu Glu Lys Ile Ser Val Pro Ser Cys Tyr Gly Gly Ile
                  10                  15                  20

 ggt gcc cct gtg agt cgg caa gtc cct gca tcc cat gac tcg gag ctg      330
 Gly Ala Pro Val Ser Arg Gln Val Pro Ala Ser His Asp Ser Glu Leu
              25                  30                  35

 atg gcc ttc atg acg agg aag ttg tgg gac ctg gag cag cag gtg aag      378
 Met Ala Phe Met Thr Arg Lys Leu Trp Asp Leu Glu Gln Gln Val Lys
          40                  45                  50

 gcc cag act gat gag ata ctg tcc aag gat cag aag ata gcg gcc cta      426
 Ala Gln Thr Asp Glu Ile Leu Ser Lys Asp Gln Lys Ile Ala Ala Leu
      55                  60                  65

 gag gac ctg gtg cag acc ctc cgg cca cac cca gcc gag gca acc ctg      474
 Glu Asp Leu Val Gln Thr Leu Arg Pro His Pro Ala Glu Ala Thr Leu
  70                  75                  80                  85

 cag cgg cag gag gaa ctg gag acg atg tgt gtg cag ctg cag cgg cag      522
 Gln Arg Gln Glu Glu Leu Glu Thr Met Cys Val Gln Leu Gln Arg Gln
                  90                  95                 100

 gtc agg gag atg gag cgg ttc ctc agt gac tat ggc ctg cag tgg gtg      570
 Val Arg Glu Met Glu Arg Phe Leu Ser Asp Tyr Gly Leu Gln Trp Val
             105                 110                 115

 ggc gag ccc atg gac cag gag gac tca gag agc aag aca gtc tca gag      618
 Gly Glu Pro Met Asp Gln Glu Asp Ser Glu Ser Lys Thr Val Ser Glu
         120                 125                 130

 cat ggc gag agg gac tgg atg aca gcc aag aag ttc tgg aag cca ggg      666
 His Gly Glu Arg Asp Trp Met Thr Ala Lys Lys Phe Trp Lys Pro Gly
     135                 140                 145

 gac tca ttg gcg ccc cct gag gtg gac ttt gac agg ctg ctg gcc agc      714
 Asp Ser Leu Ala Pro Pro Glu Val Asp Phe Asp Arg Leu Leu Ala Ser
 150                 155                 160                 165

 ctg cag gat ctt agt gag ctg gtg gta gag ggt gac acc caa gtg aca      762
 Leu Gln Asp Leu Ser Glu Leu Val Val Glu Gly Asp Thr Gln Val Thr
                 170                 175                 180

 cca gtg ccc ggc ggg gca cgg ctg cgt acc ctc gag ccc atc ccg ctg      810
 Pro Val Pro Gly Gly Ala Arg Leu Arg Thr Leu Glu Pro Ile Pro Leu
             185                 190                 195

 aag ctc tac cgg aat ggc atc atg atg ttc gac ggg ccc ttc cag ccc      858
 Lys Leu Tyr Arg Asn Gly Ile Met Met Phe Asp Gly Pro Phe Gln Pro
         200                 205                 210

 ttc tac gat ccc tcc aca cag cgc tgc ctc cga gac ata ttg gat ggc      906
 Phe Tyr Asp Pro Ser Thr Gln Arg Cys Leu Arg Asp Ile Leu Asp Gly
     215                 220                 225

 ttc ttt ccc tca gag ctc cag cga ctg tac ccc aat ggg gtc ccc ttt      954
 Phe Phe Pro Ser Glu Leu Gln Arg Leu Tyr Pro Asn Gly Val Pro Phe
 230                 235                 240                 245

 aag gtg agt gac ttg cgc aat cag gtc tac ctg gag gat gga ctg gac     1002
 Lys Val Ser Asp Leu Arg Asn Gln Val Tyr Leu Glu Asp Gly Leu Asp
                 250                 255                 260

 ccc ttc cca ggc gag ggc cgt gtg gtg ggc agg cag ctg atg cac aag     1050
 Pro Phe Pro Gly Glu Gly Arg Val Val Gly Arg Gln Leu Met His Lys
             265                 270                 275

 gcc ttg gac agg gtg gag gag cac cca ggc tcc agg atg act gct gag     1098
 Ala Leu Asp Arg Val Glu Glu His Pro Gly Ser Arg Met Thr Ala Glu
         280                 285                 290

 aaa ttt ctg aac agg ctc ccc aag ttt gtg atc cgg caa ggc gag gtg     1146
 Lys Phe Leu Asn Arg Leu Pro Lys Phe Val Ile Arg Gln Gly Glu Val
     295                 300                 305

 att gac atc cgg ggc ccc atc agg gac acc ttg cag aac tgc tgc cca     1194
 Ile Asp Ile Arg Gly Pro Ile Arg Asp Thr Leu Gln Asn Cys Cys Pro
 310                 315                 320                 325

 ttg cct gcc cgg atc cag gag att gtg gtg gag acg ccc acc ttg gcc     1242
 Leu Pro Ala Arg Ile Gln Glu Ile Val Val Glu Thr Pro Thr Leu Ala
                 330                 335                 340

 gct gag cga gag agg agc cag gag tca ccc aac acg ccg gca ccc ccg     1290
 Ala Glu Arg Glu Arg Ser Gln Glu Ser Pro Asn Thr Pro Ala Pro Pro
             345                 350                 355

 ctc tcc atg ctg cgc atc aag tct gag aat ggg gaa cag gcc ttc cta     1338
 Leu Ser Met Leu Arg Ile Lys Ser Glu Asn Gly Glu Gln Ala Phe Leu
         360                 365                 370

 ctg atg atg cag cct gac aac acc att ggg gac gtg cga gct ctg cta     1386
 Leu Met Met Gln Pro Asp Asn Thr Ile Gly Asp Val Arg Ala Leu Leu
     375                 380                 385

 gcg cag gcc agg gtc atg gat gcc tct gcc ttt gag atc ttc agc aca     1434
 Ala Gln Ala Arg Val Met Asp Ala Ser Ala Phe Glu Ile Phe Ser Thr
 390                 395                 400                 405

 ttc ccg ccc acc ctc tac cag gac gat aca ctc acg ctg cag gct gca     1482
 Phe Pro Pro Thr Leu Tyr Gln Asp Asp Thr Leu Thr Leu Gln Ala Ala
                 410                 415                 420

 ggc ctt gtg ccc aaa gca gca ctg ctg ctg cgg gca cgc cga gcc ccg     1530
 Gly Leu Val Pro Lys Ala Ala Leu Leu Leu Arg Ala Arg Arg Ala Pro
             425                 430                 435

 aag tcc agc ctg aaa ttc agt cct ggt ccc tgt ccc ggt ccc ggt ccc     1578
 Lys Ser Ser Leu Lys Phe Ser Pro Gly Pro Cys Pro Gly Pro Gly Pro
         440                 445                 450

 ggc ccc agt ccc ggt ccc ggt ccc ggc ccc agt ccc ggt ccc ggt ccc     1626
 Gly Pro Ser Pro Gly Pro Gly Pro Gly Pro Ser Pro Gly Pro Gly Pro
     455                 460                 465

 ggc ccc agt ccc ggt ccc ggt ccc ggc ccc agt ccc tgt cct gga ccc     1674
 Gly Pro Ser Pro Gly Pro Gly Pro Gly Pro Ser Pro Cys Pro Gly Pro
 470                 475                 480                 485

 agt ccc agc ccc caa taa agcacccgcc ccctcaaaaa aaaaa                 1717
 Ser Pro Ser Pro Gln 
                 490





      <210> 400
      <211> 821
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (108)..(275)

      <400> 400
 ggagggaaag ggctccccca cttcaggctg gtcactgtat gttgacttcc ctctgggaag     60

 caaaattcca cttgtaaaaa tcagcttcca agacaaaaga tgatccg  atg tca ctt     116
                                                      Met Ser Leu
                                                        1

 ctg ggt cac cag gaa ggg aca cag gat ctc tct gaa ctt tgg aac aga      164
 Leu Gly His Gln Glu Gly Thr Gln Asp Leu Ser Glu Leu Trp Asn Arg
       5                  10                  15

 ccc tca tat tct ggg gcc aga agt ttg ccc aga aag cag cag gtg gct      212
 Pro Ser Tyr Ser Gly Ala Arg Ser Leu Pro Arg Lys Gln Gln Val Ala
  20                  25                  30                  35

 ctg cct ggc tgt aga gcc cag ctc att ggc tgt ccc tgg gct tcg tct      260
 Leu Pro Gly Cys Arg Ala Gln Leu Ile Gly Cys Pro Trp Ala Ser Ser
                  40                  45                  50

 ccc tct tcc gag tag ttgctgcctt tcttcagatc aggttaccac aatgcctccc      315
 Pro Ser Ser Glu 
              55

 cgctgctgac gcttcatccc ccacacctcc agccccagtt acctggagct tctcagaacc    375

 cactttgccg gtgctaaaac acaagagggg gtgaaagtgg ctgccagtaa tggccagaaa    435

 ccaaccacca gaggccaggc tgaaagacaa gctccgggtg tccaggggct gacgggccaa    495

 ccatgtggca ggtcccaggc cccacccact gcgccatccg cctctgagct ccacagtggt    555

 cccactaatg ggaacctcct ctagggagag tgatactgca ccttcacccg taggactcat    615

 atttataaca atgtgtaatg gctgtagcaa aaagcccttg tttctagatg taaatggtca    675

 aagaaacaag cgctctattg ttttgaataa aatagttcaa atgagtcctg tatcattgta    735

 tctcctattc tggattagtg ccttttggac agtagactgt tctgtaatta aaatgtagta    795

 tactgctttt ttgtacagtt ttgttt                                         821




      <210> 401
      <211> 3832
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (110)..(3109)

      <400> 401
 gtggaaaatg gcgctgacgt gagcgcgaac tcgcactgcc cagagggtgg ccgccgccta     60

 agctgcagcc gccggagccg cagaaacaag aggccgagcc gtgtcgaag    atg gag     115
                                                          Met Glu
                                                            1

 gag aaa ccc tca ggg ccc atc cca gac atg ctg gcc act gca gag ccc      163
 Glu Lys Pro Ser Gly Pro Ile Pro Asp Met Leu Ala Thr Ala Glu Pro
           5                  10                  15

 agc tcc agt gag acc gac aag gag gtg ttg tcc ccg gct gtg cca gct      211
 Ser Ser Ser Glu Thr Asp Lys Glu Val Leu Ser Pro Ala Val Pro Ala
      20                  25                  30

 gca gcc cct tcc tcc tcc atg tcg gag gag cca ggc cct gag cag gca      259
 Ala Ala Pro Ser Ser Ser Met Ser Glu Glu Pro Gly Pro Glu Gln Ala
  35                  40                  45                  50

 gcc aca ccg cca gtg tgg gaa cgt gga ggg gct gga ggg atg cag cag      307
 Ala Thr Pro Pro Val Trp Glu Arg Gly Gly Ala Gly Gly Met Gln Gln
                  55                  60                  65

 ggc tcc tcc cca gcc cca gac agc tgc cag cct ggc ccc gga ccc agc      355
 Gly Ser Ser Pro Ala Pro Asp Ser Cys Gln Pro Gly Pro Gly Pro Ser
              70                  75                  80

 cct ggc ctg acc agc ata gtc tcc ggg acc agc gag gac ctg cgg cct      403
 Pro Gly Leu Thr Ser Ile Val Ser Gly Thr Ser Glu Asp Leu Arg Pro
          85                  90                  95

 ccc aga cga cgc cca cct cca ggg aag caa atc cct tgc tcc agc cct      451
 Pro Arg Arg Arg Pro Pro Pro Gly Lys Gln Ile Pro Cys Ser Ser Pro
     100                 105                 110

 ggc tgc tgc ctc agt ttt ccc agc gtc cgt gac ctg gca cag cat ctg      499
 Gly Cys Cys Leu Ser Phe Pro Ser Val Arg Asp Leu Ala Gln His Leu
 115                 120                 125                 130

 cga acc cac tgc ccg ccc aca cag tcc ctg gaa ggc aag ctc ttc cgc      547
 Arg Thr His Cys Pro Pro Thr Gln Ser Leu Glu Gly Lys Leu Phe Arg
                 135                 140                 145

 tgc tca gcc ctg agc tgc acc gag acc ttc ccc agc atg cag gag ctg      595
 Cys Ser Ala Leu Ser Cys Thr Glu Thr Phe Pro Ser Met Gln Glu Leu
             150                 155                 160

 gtg gct cac agc aaa ctg cac tac aaa ccc aat cgc tac ttc aag tgt      643
 Val Ala His Ser Lys Leu His Tyr Lys Pro Asn Arg Tyr Phe Lys Cys
         165                 170                 175

 gag aac tgc ctc ctg cgc ttc cgc acg cac cgc tcg ctc ttc aag cac      691
 Glu Asn Cys Leu Leu Arg Phe Arg Thr His Arg Ser Leu Phe Lys His
     180                 185                 190

 ctg cat gtt tgc gcg gag cat gcg cag agc cca gcc ccg ccg cca ccc      739
 Leu His Val Cys Ala Glu His Ala Gln Ser Pro Ala Pro Pro Pro Pro
 195                 200                 205                 210

 ccg gcc ctg gac cga gag ccg ccc gcg ccg gag cgc ccc ccg gag gtt      787
 Pro Ala Leu Asp Arg Glu Pro Pro Ala Pro Glu Arg Pro Pro Glu Val
                 215                 220                 225

 gac ccc gca tca gcg ccg ggc ctg cca ttc ccg ctg ctg gaa ccc ttc      835
 Asp Pro Ala Ser Ala Pro Gly Leu Pro Phe Pro Leu Leu Glu Pro Phe
             230                 235                 240

 acg acc ccc gcc cct gcc ccc acc gga ccg ttc ctg ccc tac ttg aac      883
 Thr Thr Pro Ala Pro Ala Pro Thr Gly Pro Phe Leu Pro Tyr Leu Asn
         245                 250                 255

 cct gcg ccc ttt ggc cta agc ccc ccg cgc ctg cgc ccc ttc ctg gcc      931
 Pro Ala Pro Phe Gly Leu Ser Pro Pro Arg Leu Arg Pro Phe Leu Ala
     260                 265                 270

 gct gca ccc ggg ccg ccg gct tcc agc gcc gcc gtc tgg aaa aag agc      979
 Ala Ala Pro Gly Pro Pro Ala Ser Ser Ala Ala Val Trp Lys Lys Ser
 275                 280                 285                 290

 caa ggt gct ggc agc agc ccc cga aga ccc cag ggc ggc tcc gac gcg     1027
 Gln Gly Ala Gly Ser Ser Pro Arg Arg Pro Gln Gly Gly Ser Asp Ala
                 295                 300                 305

 ccc tca ggg cac gcg gcc ccg agc cgc atc gtg tgg gag cac aca cgc     1075
 Pro Ser Gly His Ala Ala Pro Ser Arg Ile Val Trp Glu His Thr Arg
             310                 315                 320

 ggc cgc tac tcg tgc atg cag tgc gcc ttc tcc acg gcc tcg cgg ccc     1123
 Gly Arg Tyr Ser Cys Met Gln Cys Ala Phe Ser Thr Ala Ser Arg Pro
         325                 330                 335

 gcc atg acc ctg cac ctg gag gac cac cgc ccc ggc gcc ccc gcg gcc     1171
 Ala Met Thr Leu His Leu Glu Asp His Arg Pro Gly Ala Pro Ala Ala
     340                 345                 350

 ccc gcg ccc ggg ccg ccg cgc ccc gac gcc ccc gcg ggg tcc cgg ggg     1219
 Pro Ala Pro Gly Pro Pro Arg Pro Asp Ala Pro Ala Gly Ser Arg Gly
 355                 360                 365                 370

 ccc cca gga gtc ttt gtc ccc atc agt ttc ttc att cgg cca ccc cca     1267
 Pro Pro Gly Val Phe Val Pro Ile Ser Phe Phe Ile Arg Pro Pro Pro
                 375                 380                 385

 gat cta ggc cac gcc tct tcc cag tct gtc agt atc ttt cca gag aaa     1315
 Asp Leu Gly His Ala Ser Ser Gln Ser Val Ser Ile Phe Pro Glu Lys
             390                 395                 400

 cct aga gcc aac acg tcc gtc cag gga cct ctc ccc tac ccc atc acc     1363
 Pro Arg Ala Asn Thr Ser Val Gln Gly Pro Leu Pro Tyr Pro Ile Thr
         405                 410                 415

 cac gga gat ggg aca gcc ctt cct aaa cga cct cct acc ctc aag ccg     1411
 His Gly Asp Gly Thr Ala Leu Pro Lys Arg Pro Pro Thr Leu Lys Pro
     420                 425                 430

 gcc ccc aac ccc cat gca cag gag ccc agc cct ctt ggg ccc cgg ctc     1459
 Ala Pro Asn Pro His Ala Gln Glu Pro Ser Pro Leu Gly Pro Arg Leu
 435                 440                 445                 450

 cgc cca gca ggg ggc gcc ctg gaa tct cag act cgg ggg aat gaa agc     1507
 Arg Pro Ala Gly Gly Ala Leu Glu Ser Gln Thr Arg Gly Asn Glu Ser
                 455                 460                 465

 cgg gag agc agt ggg gat agc ggg cag cag ccc cca ccc tgc gtg ctg     1555
 Arg Glu Ser Ser Gly Asp Ser Gly Gln Gln Pro Pro Pro Cys Val Leu
             470                 475                 480

 acc gtg gag cag aag cca cag tca ctt cct gaa ggc agc ggt ccc agc     1603
 Thr Val Glu Gln Lys Pro Gln Ser Leu Pro Glu Gly Ser Gly Pro Ser
         485                 490                 495

 tcg ggt ccc act cat ccc atg gcc cat cac ctg cct gca gcc atg gag     1651
 Ser Gly Pro Thr His Pro Met Ala His His Leu Pro Ala Ala Met Glu
     500                 505                 510

 agc cat cag gac ttc cgg agc atc aaa gca aag ttc cag gcc tct cag     1699
 Ser His Gln Asp Phe Arg Ser Ile Lys Ala Lys Phe Gln Ala Ser Gln
 515                 520                 525                 530

 ccg gag ccc agc gac ctg ccc aaa aaa cct ccg aag cct gag ttt ggt     1747
 Pro Glu Pro Ser Asp Leu Pro Lys Lys Pro Pro Lys Pro Glu Phe Gly
                 535                 540                 545

 aaa ctg aag aag ttc tcc cag cct gag cta agc gag cac ccc aag aag     1795
 Lys Leu Lys Lys Phe Ser Gln Pro Glu Leu Ser Glu His Pro Lys Lys
             550                 555                 560

 gcc ccg ctg cct gag ttt ggt gca gtg tcc ttg aag ccc ccg ccg cct     1843
 Ala Pro Leu Pro Glu Phe Gly Ala Val Ser Leu Lys Pro Pro Pro Pro
         565                 570                 575

 gag gtc act gac ctc ccc aag aag ccc ccg ccg cct gag gtc act gac     1891
 Glu Val Thr Asp Leu Pro Lys Lys Pro Pro Pro Pro Glu Val Thr Asp
     580                 585                 590

 ctc ccc aag aag ccc ccg ccg cct gag gtc act gac ctc ccc aag aag     1939
 Leu Pro Lys Lys Pro Pro Pro Pro Glu Val Thr Asp Leu Pro Lys Lys
 595                 600                 605                 610

 ccc ccg ccg cct gag gtc act gac ctc ccc aag aag ccg tcc aaa ctg     1987
 Pro Pro Pro Pro Glu Val Thr Asp Leu Pro Lys Lys Pro Ser Lys Leu
                 615                 620                 625

 gag ttg agt gac ctc tcc aag aag ttc cca cag ctg ggg gcc act ccg     2035
 Glu Leu Ser Asp Leu Ser Lys Lys Phe Pro Gln Leu Gly Ala Thr Pro
             630                 635                 640

 ttt cca agg aag ccc ctg cag cct gag gtc ggt gag gcc cct ttg aag     2083
 Phe Pro Arg Lys Pro Leu Gln Pro Glu Val Gly Glu Ala Pro Leu Lys
         645                 650                 655

 gcc tcg ctg ccg gag cct ggt gcg ccg gcc cgg aaa ccc ctg cag ccc     2131
 Ala Ser Leu Pro Glu Pro Gly Ala Pro Ala Arg Lys Pro Leu Gln Pro
     660                 665                 670

 gac gaa ctc agt cac ccc gcc aga ccc ccc tcc gaa ccc aaa tcc ggc     2179
 Asp Glu Leu Ser His Pro Ala Arg Pro Pro Ser Glu Pro Lys Ser Gly
 675                 680                 685                 690

 gca ttc ccc agg aag ctc tgg caa ccc gag gcc ggt gag gct acc ccg     2227
 Ala Phe Pro Arg Lys Leu Trp Gln Pro Glu Ala Gly Glu Ala Thr Pro
                 695                 700                 705

 agg tcc ccg cag cct gag ttg agt acc ttt ccc aag aag cct gcg cag     2275
 Arg Ser Pro Gln Pro Glu Leu Ser Thr Phe Pro Lys Lys Pro Ala Gln
             710                 715                 720

 cct gag ttc aac gtg tac ccc aaa aag cct ccg cag cct cag gtc ggt     2323
 Pro Glu Phe Asn Val Tyr Pro Lys Lys Pro Pro Gln Pro Gln Val Gly
         725                 730                 735

 ggc ctc cct aag aag tcc gtg ccg cag cct gag ttc agc gag gcc gct     2371
 Gly Leu Pro Lys Lys Ser Val Pro Gln Pro Glu Phe Ser Glu Ala Ala
     740                 745                 750

 cag act ccc ctc tgg aag cct cag tcc agc gag ccg aag cgc gac tcc     2419
 Gln Thr Pro Leu Trp Lys Pro Gln Ser Ser Glu Pro Lys Arg Asp Ser
 755                 760                 765                 770

 agc gcc ttt ccc aaa aag gcc tcc cag cct ccg ctg agt gac ttt ccc     2467
 Ser Ala Phe Pro Lys Lys Ala Ser Gln Pro Pro Leu Ser Asp Phe Pro
                 775                 780                 785

 aag aag cct ccg cag cct gag ctt ggg gac ctc acc agg acc tcc tca     2515
 Lys Lys Pro Pro Gln Pro Glu Leu Gly Asp Leu Thr Arg Thr Ser Ser
             790                 795                 800

 gag ccc gaa gtc agc gtg ctt ccc aag agg ccg cgg ccg gcc gaa ttc     2563
 Glu Pro Glu Val Ser Val Leu Pro Lys Arg Pro Arg Pro Ala Glu Phe
         805                 810                 815

 aaa gcg ctc tcc aag aag ccc ccg cag ccc gag ctg ggc ggc ctc ccc     2611
 Lys Ala Leu Ser Lys Lys Pro Pro Gln Pro Glu Leu Gly Gly Leu Pro
     820                 825                 830

 agg acc tcc tca gag ccc gag ttc aac tca ctc ccc agg aag ctg ctg     2659
 Arg Thr Ser Ser Glu Pro Glu Phe Asn Ser Leu Pro Arg Lys Leu Leu
 835                 840                 845                 850

 cag ccg gag cgc cgg ggg cca ccc cgc aag ttc tca cag cct gag ccc     2707
 Gln Pro Glu Arg Arg Gly Pro Pro Arg Lys Phe Ser Gln Pro Glu Pro
                 855                 860                 865

 agc gct gtc ctc aag aga cac ccg cag cct gag ttc ttc ggt gat ctc     2755
 Ser Ala Val Leu Lys Arg His Pro Gln Pro Glu Phe Phe Gly Asp Leu
             870                 875                 880

 cct cga aag cct cca ctc ccc agc tcc gct tcc gag agc tca ctg cct     2803
 Pro Arg Lys Pro Pro Leu Pro Ser Ser Ala Ser Glu Ser Ser Leu Pro
         885                 890                 895

 gcg gcc gtg gcc ggc ttc agc tcc cgg cac ccg ctc agc cct ggg ttt     2851
 Ala Ala Val Ala Gly Phe Ser Ser Arg His Pro Leu Ser Pro Gly Phe
     900                 905                 910

 gga gcc gct ggg aca ccc cgc tgg agg tca gga ggc ctg gtt cac agt     2899
 Gly Ala Ala Gly Thr Pro Arg Trp Arg Ser Gly Gly Leu Val His Ser
 915                 920                 925                 930

 gga ggg gcc agg cca ggc ctc aga ccc agc cat cca ccc cgg cgg agg     2947
 Gly Gly Ala Arg Pro Gly Leu Arg Pro Ser His Pro Pro Arg Arg Arg
                 935                 940                 945

 cct ctg ccc cct gcc agc agc ctg gga cac cct cca gcc aag ccc ccg     2995
 Pro Leu Pro Pro Ala Ser Ser Leu Gly His Pro Pro Ala Lys Pro Pro
             950                 955                 960

 ctg ccc ccg ggg ccc gtg gat atg cag agc ttt cgg aga ccc tct gca     3043
 Leu Pro Pro Gly Pro Val Asp Met Gln Ser Phe Arg Arg Pro Ser Ala
         965                 970                 975

 gca tcc ata gat cta cgg agg acc cgc tcg gcc gct ggg ctc cac tat     3091
 Ala Ser Ile Asp Leu Arg Arg Thr Arg Ser Ala Ala Gly Leu His Tyr
     980                 985                 990

 cca gga ccg aca gcc tga agacat cccgcaggtc ccagatgaga tctacgagct     3145
 Pro Gly Pro Thr Ala 
 995

 gtatgacgat gtggaaccca gagatgactc cagccccaga cccaagggca gagatgaagc   3205

 gcctcagttc agcaagccgc caggaggcca ccacaagacc cagcgctcag gaaggagaca   3265

 ggatccccag cccacagcag ttgccaccat ggacccaaag tagcctggaa gcagctgaag   3325

 gaaggcagac caaggccgag acgggaagtt ccaggaaaga agttcacagt ttgaaccggg   3385

 cagatcagtg gcaccacacg caacgcatga ctgaatcgga gccccaagcc taagcacacc   3445

 gtcccgaggg atggcaagca cactcgggat ccggcgcggc gagaacctgg cagcgaccag   3505

 tacccgggca agacggaaac atgctggtcc cgggaacccc aaaggaaata ttgatacctg   3565

 accccagaaa caagactttg tccccctgta cagcccatga atatacactc aatcaacatt   3625

 ctagcacccc ctgatcaaac acacctccct gtacatcact acactaacgg gacagaaaca   3685

 accaaccaaa cccacaccaa acccacactc caacagacaa tacgataatc tcactcaacc   3745

 cctcacacac accacacaac caccaacaca acagcaccct actcccgcca tatctcacat   3805

 aaataatacc cataccaact aacatcg                                       3832




      <210> 402
      <211> 569
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (107)..(514)

      <400> 402
 tttcgtgagg agagagagag aggagaaacc gaaactactg gggaaaggga gggctcactg     60

 agaaccatcc cagtaacccg accgccgctg gtcttcgctg gacacc   atg aat cac     115
                                                      Met Asn His
                                                        1

 act gtc caa acc ttc ttc tct cct gtc aac agc ggc cag ccc ccc aac      163
 Thr Val Gln Thr Phe Phe Ser Pro Val Asn Ser Gly Gln Pro Pro Asn
       5                  10                  15

 tat gag atg ctc aag gag gag cac gag gtg gct gtg ctg ggg gcg ccc      211
 Tyr Glu Met Leu Lys Glu Glu His Glu Val Ala Val Leu Gly Ala Pro
  20                  25                  30                  35

 cac aac cct gct ccc ccg acg tcc acc gtg atc cac atc cgc agc gag      259
 His Asn Pro Ala Pro Pro Thr Ser Thr Val Ile His Ile Arg Ser Glu
                  40                  45                  50

 acc tcc gtg ccc gac cat gtc gtc tgg tcc ctg ttc aac acc ctc ttc      307
 Thr Ser Val Pro Asp His Val Val Trp Ser Leu Phe Asn Thr Leu Phe
              55                  60                  65

 atg aac ccc tgc tgc ctg ggc ttc ata gca ttc gcc tac tcc gtg aag      355
 Met Asn Pro Cys Cys Leu Gly Phe Ile Ala Phe Ala Tyr Ser Val Lys
          70                  75                  80

 gtg cgt atg gcc cca ggg aat gct cag agg gtg ccg ctg agc ctg gag      403
 Val Arg Met Ala Pro Gly Asn Ala Gln Arg Val Pro Leu Ser Leu Glu
      85                  90                  95

 ctc cac ctg ccc aca tgc tgc ctg ggg tgg gga ctt gtg tgt ccc tgt      451
 Leu His Leu Pro Thr Cys Cys Leu Gly Trp Gly Leu Val Cys Pro Cys
 100                 105                 110                 115

 gac tgt gag ttt gtg tgc acc tct gtc ccg tgt gtg ccc acg tca gtg      499
 Asp Cys Glu Phe Val Cys Thr Ser Val Pro Cys Val Pro Thr Ser Val
                 120                 125                 130

 gct ttg tct gtg tga tctgtgtgtg tgtgtggctt ggggaatctg cccagtgcag      554
 Ala Leu Ser Val 
             135

 gtttacgagg aggct                                                     569




      <210> 403
      <211> 1029
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (77)..(1021)

      <400> 403
 ccgggtcgag ccacgcgtcc ggctggaggc agttgcttcc ctgtagaggg tccggctgcg     60

 gccagtattt tgtgtc    atg act tct caa gag aag aca gaa gag tat cct     109
                      Met Thr Ser Gln Glu Lys Thr Glu Glu Tyr Pro
                        1               5                  10

 ttt gca gat ata ttt gat gaa gat gaa act gaa agg aat ttt ttg ttg      157
 Phe Ala Asp Ile Phe Asp Glu Asp Glu Thr Glu Arg Asn Phe Leu Leu
              15                  20                  25

 tcc aaa cct gtt tgc ttt gtt gta ttt ggg aaa cca ggt gtt ggg aaa      205
 Ser Lys Pro Val Cys Phe Val Val Phe Gly Lys Pro Gly Val Gly Lys
          30                  35                  40

 aca aca tta gcc cgt tac ata aca cag gca tgg aaa tgt att cgt gtt      253
 Thr Thr Leu Ala Arg Tyr Ile Thr Gln Ala Trp Lys Cys Ile Arg Val
      45                  50                  55

 gaa gct ttg cca att tta gaa gaa cag att gct gct gaa acc gaa tca      301
 Glu Ala Leu Pro Ile Leu Glu Glu Gln Ile Ala Ala Glu Thr Glu Ser
  60                  65                  70                  75

 gga gtt atg ttg caa tca atg ttg atc agc ggt caa agc att cca gat      349
 Gly Val Met Leu Gln Ser Met Leu Ile Ser Gly Gln Ser Ile Pro Asp
                  80                  85                  90

 gaa ctt gtc ata aag cta atg ttg gag aag ctc aac tcc cca gaa gtc      397
 Glu Leu Val Ile Lys Leu Met Leu Glu Lys Leu Asn Ser Pro Glu Val
              95                 100                 105

 tgt cac ttt ggt tat att atc act gaa ata cca tca ctt tca cag gat      445
 Cys His Phe Gly Tyr Ile Ile Thr Glu Ile Pro Ser Leu Ser Gln Asp
         110                 115                 120

 gcc atg act acc tta cag caa ata gaa tta att aaa aac tta aac ctg      493
 Ala Met Thr Thr Leu Gln Gln Ile Glu Leu Ile Lys Asn Leu Asn Leu
     125                 130                 135

 aaa cct gat gtt ata atc aat ata aag tgt cct gac tat gat ttg tgc      541
 Lys Pro Asp Val Ile Ile Asn Ile Lys Cys Pro Asp Tyr Asp Leu Cys
 140                 145                 150                 155

 cag aga att tct ggg caa aga cag cac aat aat acg gga tac ata tac      589
 Gln Arg Ile Ser Gly Gln Arg Gln His Asn Asn Thr Gly Tyr Ile Tyr
                 160                 165                 170

 agt aga gac cag tgg gat cct gaa gtc att gag aat cat agg aaa aag      637
 Ser Arg Asp Gln Trp Asp Pro Glu Val Ile Glu Asn His Arg Lys Lys
             175                 180                 185

 aag aaa gaa gcc caa aag gac gga aaa gga gaa gag gaa gaa gag gaa      685
 Lys Lys Glu Ala Gln Lys Asp Gly Lys Gly Glu Glu Glu Glu Glu Glu
         190                 195                 200

 gaa gag caa gaa gaa gaa gag gca ttt att gcc gaa atg cag atg gtg      733
 Glu Glu Gln Glu Glu Glu Glu Ala Phe Ile Ala Glu Met Gln Met Val
     205                 210                 215

 gct gaa att ctt cat cat cta gtt cag agg cct gaa gat tat ttg gaa      781
 Ala Glu Ile Leu His His Leu Val Gln Arg Pro Glu Asp Tyr Leu Glu
 220                 225                 230                 235

 aat gtt gaa aac att gtt aag ctt tat aag gaa aca att ctc caa act      829
 Asn Val Glu Asn Ile Val Lys Leu Tyr Lys Glu Thr Ile Leu Gln Thr
                 240                 245                 250

 tta gaa gaa gta atg gct gaa cac aat ccc cag tat ctc att gag cta      877
 Leu Glu Glu Val Met Ala Glu His Asn Pro Gln Tyr Leu Ile Glu Leu
             255                 260                 265

 aat gga aat aaa cca gca gag gag ctc ttt atg gtg agt gca gtg tta      925
 Asn Gly Asn Lys Pro Ala Glu Glu Leu Phe Met Val Ser Ala Val Leu
         270                 275                 280

 agc agg aat act tca cag cat gga aaa ttt aaa tct att gac agt att      973
 Ser Arg Asn Thr Ser Gln His Gly Lys Phe Lys Ser Ile Asp Ser Ile
     285                 290                 295

 gta ctt ctt tta ata aac aga agc ata ttt ata ttt gaa cac cat taa     1021
 Val Leu Leu Leu Ile Asn Arg Ser Ile Phe Ile Phe Glu His His 
 300                 305                 310

 aaaaaaaa                                                            1029




      <210> 404
      <211> 2744
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2694)

      <400> 404
  atg tgg aaa aag gat aat aaa aca caa agg aat aag agt tgt ata act      48
  Met Trp Lys Lys Asp Asn Lys Thr Gln Arg Asn Lys Ser Cys Ile Thr
    1               5                  10                  15

 ctg agg gac gta aaa gaa gaa tgt aga ttt atg ggg gta tgt ttt atc       96
 Leu Arg Asp Val Lys Glu Glu Cys Arg Phe Met Gly Val Cys Phe Ile
              20                  25                  30

 cct tat ggt atc ccc act acc ttg agc tgt gct tgg cac gta gga agc      144
 Pro Tyr Gly Ile Pro Thr Thr Leu Ser Cys Ala Trp His Val Gly Ser
          35                  40                  45

 aat gac tgg ggt tta gtg gtt act ctc ctg ttt gga aaa aca aac tca      192
 Asn Asp Trp Gly Leu Val Val Thr Leu Leu Phe Gly Lys Thr Asn Ser
      50                  55                  60

 gag aag tac cta gaa cag tgt gaa cac tca ttt ctt cct cca aca tca      240
 Glu Lys Tyr Leu Glu Gln Cys Glu His Ser Phe Leu Pro Pro Thr Ser
  65                  70                  75                  80

 cct ggg gtt cct aag tgc tta gaa gaa atg aaa cgg gaa gcc agg act      288
 Pro Gly Val Pro Lys Cys Leu Glu Glu Met Lys Arg Glu Ala Arg Thr
                  85                  90                  95

 att aag att gat aga aga ttg acg ggt gcc aat ata att gat gaa cct      336
 Ile Lys Ile Asp Arg Arg Leu Thr Gly Ala Asn Ile Ile Asp Glu Pro
             100                 105                 110

 ctc cag caa gtt atc cag ttt tcc ttg agg gat tat gtc cag tat tgg      384
 Leu Gln Gln Val Ile Gln Phe Ser Leu Arg Asp Tyr Val Gln Tyr Trp
         115                 120                 125

 tat tat aca cta agc gat gat gaa tct ttt ctt ctt gaa att agg cag      432
 Tyr Tyr Thr Leu Ser Asp Asp Glu Ser Phe Leu Leu Glu Ile Arg Gln
     130                 135                 140

 act ctt caa aac gca ctc att cag ttt gct act agg tca aaa gaa ata      480
 Thr Leu Gln Asn Ala Leu Ile Gln Phe Ala Thr Arg Ser Lys Glu Ile
 145                 150                 155                 160

 gac tgg caa cct tat ttt act aca cgc att gta gat gac ttt ggc aca      528
 Asp Trp Gln Pro Tyr Phe Thr Thr Arg Ile Val Asp Asp Phe Gly Thr
                 165                 170                 175

 cac tta cga gta ttc aga aag gct caa cag aaa ata aca gag aaa gat      576
 His Leu Arg Val Phe Arg Lys Ala Gln Gln Lys Ile Thr Glu Lys Asp
             180                 185                 190

 gat caa gtg aaa ggt aca gca gaa gat ctt gta gat acc ttc ttt gaa      624
 Asp Gln Val Lys Gly Thr Ala Glu Asp Leu Val Asp Thr Phe Phe Glu
         195                 200                 205

 gtt gaa gtt gaa atg gag aag gag gtt tgc cgt gat cta gtg tgc act      672
 Val Glu Val Glu Met Glu Lys Glu Val Cys Arg Asp Leu Val Cys Thr
     210                 215                 220

 tcc ccc aaa gat gaa gaa gga ttc cta agg gat ttg tgt gag gtc tta      720
 Ser Pro Lys Asp Glu Glu Gly Phe Leu Arg Asp Leu Cys Glu Val Leu
 225                 230                 235                 240

 cta tat tta ttg cta cct cct gga gat ttc cag aac aag atc atg cga      768
 Leu Tyr Leu Leu Leu Pro Pro Gly Asp Phe Gln Asn Lys Ile Met Arg
                 245                 250                 255

 tac ttt gtc agg gaa atc ctt gca cga gga att ctt ctt cca tta ata      816
 Tyr Phe Val Arg Glu Ile Leu Ala Arg Gly Ile Leu Leu Pro Leu Ile
             260                 265                 270

 aat caa ctc agt gat cct gat tat att aat cag tat gtc ata tgg atg      864
 Asn Gln Leu Ser Asp Pro Asp Tyr Ile Asn Gln Tyr Val Ile Trp Met
         275                 280                 285

 atc cgt gat tct aac tgc aac tat gag gcc ttt atg aac att att aaa      912
 Ile Arg Asp Ser Asn Cys Asn Tyr Glu Ala Phe Met Asn Ile Ile Lys
     290                 295                 300

 ttg agt gac aat att gga gag cta gaa gca gtc aga gat aag gca gca      960
 Leu Ser Asp Asn Ile Gly Glu Leu Glu Ala Val Arg Asp Lys Ala Ala
 305                 310                 315                 320

 gaa gaa tta cag tat ctt aga tct cta gat aca gct ggt gat gat atc     1008
 Glu Glu Leu Gln Tyr Leu Arg Ser Leu Asp Thr Ala Gly Asp Asp Ile
                 325                 330                 335

 aac act atc aaa aat caa ata aat agc tta cta ttc gta aag aag gta     1056
 Asn Thr Ile Lys Asn Gln Ile Asn Ser Leu Leu Phe Val Lys Lys Val
             340                 345                 350

 tgt gac tca aga ata cag cga ttg cag tca ggc aaa gaa ata aat act     1104
 Cys Asp Ser Arg Ile Gln Arg Leu Gln Ser Gly Lys Glu Ile Asn Thr
         355                 360                 365

 gtg aaa ctt gca gca aac ttt ggg aaa ctt tgc aca gtc ccc ctg gac     1152
 Val Lys Leu Ala Ala Asn Phe Gly Lys Leu Cys Thr Val Pro Leu Asp
     370                 375                 380

 agc att ctt gta gac aat gtt gca cta caa ttt ttt atg gat tac atg     1200
 Ser Ile Leu Val Asp Asn Val Ala Leu Gln Phe Phe Met Asp Tyr Met
 385                 390                 395                 400

 cag caa act gga ggt caa gca cat cta ttc ttt tgg atg aca gtg gaa     1248
 Gln Gln Thr Gly Gly Gln Ala His Leu Phe Phe Trp Met Thr Val Glu
                 405                 410                 415

 gga tac cgg gtt acc gcc caa cag cag cta gaa gtt tta tta agt cgt     1296
 Gly Tyr Arg Val Thr Ala Gln Gln Gln Leu Glu Val Leu Leu Ser Arg
             420                 425                 430

 cag aga gat gga aaa cat caa acc aac caa acc aaa ggt ctt tta aga     1344
 Gln Arg Asp Gly Lys His Gln Thr Asn Gln Thr Lys Gly Leu Leu Arg
         435                 440                 445

 gca gct gct gtt gga att tat gaa cag tat tta tca gaa aag gca tct     1392
 Ala Ala Ala Val Gly Ile Tyr Glu Gln Tyr Leu Ser Glu Lys Ala Ser
     450                 455                 460

 cca aga gtt act gtt gat gac tat tta gta gca aaa tta gca gat act     1440
 Pro Arg Val Thr Val Asp Asp Tyr Leu Val Ala Lys Leu Ala Asp Thr
 465                 470                 475                 480

 ttg aat cat gaa gat cca acc cct gaa atc ttt gat gac att caa aga     1488
 Leu Asn His Glu Asp Pro Thr Pro Glu Ile Phe Asp Asp Ile Gln Arg
                 485                 490                 495

 aag gta tat gaa ttg atg cta cga gat gaa aga ttt tat cct tcc ttc     1536
 Lys Val Tyr Glu Leu Met Leu Arg Asp Glu Arg Phe Tyr Pro Ser Phe
             500                 505                 510

 aga cag aat gca ctt tat gtg cgc atg tta gct gag ctt gac atg tta     1584
 Arg Gln Asn Ala Leu Tyr Val Arg Met Leu Ala Glu Leu Asp Met Leu
         515                 520                 525

 aaa gat cct agt ttc aga gga tcc gat gat ggg gat gga gaa tct ttt     1632
 Lys Asp Pro Ser Phe Arg Gly Ser Asp Asp Gly Asp Gly Glu Ser Phe
     530                 535                 540

 aat ggg tct cct aca gga agc ata aat ttg tct tta gat gac ctt tca     1680
 Asn Gly Ser Pro Thr Gly Ser Ile Asn Leu Ser Leu Asp Asp Leu Ser
 545                 550                 555                 560

 aat gtt tct tct gat gac tca gta caa ctt cat gcc tac att tca gac     1728
 Asn Val Ser Ser Asp Asp Ser Val Gln Leu His Ala Tyr Ile Ser Asp
                 565                 570                 575

 aca gta tat gct gac tat gac cca tat gct gtg gca ggc gtt tgt aat     1776
 Thr Val Tyr Ala Asp Tyr Asp Pro Tyr Ala Val Ala Gly Val Cys Asn
             580                 585                 590

 gat cat ggc aag aca tat gca tta tat gcc atc act gta cac cgg cgc     1824
 Asp His Gly Lys Thr Tyr Ala Leu Tyr Ala Ile Thr Val His Arg Arg
         595                 600                 605

 aac cta aac agt gag gag atg tgg aaa acc tat cgt cgt tat agt gac     1872
 Asn Leu Asn Ser Glu Glu Met Trp Lys Thr Tyr Arg Arg Tyr Ser Asp
     610                 615                 620

 ttc cat gac ttc cac atg aga atc act gaa cag ttt gaa agt ctc tca     1920
 Phe His Asp Phe His Met Arg Ile Thr Glu Gln Phe Glu Ser Leu Ser
 625                 630                 635                 640

 agc ata ttg aaa ctt cct gga aaa aag act ttt aat aat atg gat aga     1968
 Ser Ile Leu Lys Leu Pro Gly Lys Lys Thr Phe Asn Asn Met Asp Arg
                 645                 650                 655

 gat ttt tta gaa aag aga aaa aag gat cta aat gca tat ttg cag tta     2016
 Asp Phe Leu Glu Lys Arg Lys Lys Asp Leu Asn Ala Tyr Leu Gln Leu
             660                 665                 670

 ctg tta gct cct gaa atg atg aag gca tcc cca gct tta gct cac tat     2064
 Leu Leu Ala Pro Glu Met Met Lys Ala Ser Pro Ala Leu Ala His Tyr
         675                 680                 685

 gtg tat gat ttc ctt gag aac aaa gcc tac agt aaa gga aaa ggg gat     2112
 Val Tyr Asp Phe Leu Glu Asn Lys Ala Tyr Ser Lys Gly Lys Gly Asp
     690                 695                 700

 ttt gct cgc aag atg gac act ttt gta aat cca ctt cgc aat tca atg     2160
 Phe Ala Arg Lys Met Asp Thr Phe Val Asn Pro Leu Arg Asn Ser Met
 705                 710                 715                 720

 agg aat gtt tca aat gca gtt aaa tcc ctt cct gat agc ttg gca gag     2208
 Arg Asn Val Ser Asn Ala Val Lys Ser Leu Pro Asp Ser Leu Ala Glu
                 725                 730                 735

 gga atg act aaa atg tca gac aac atg ggc aaa atg tca gaa aga tta     2256
 Gly Met Thr Lys Met Ser Asp Asn Met Gly Lys Met Ser Glu Arg Leu
             740                 745                 750

 ggt caa gac ata aag caa tca ttt ttt aag gtg cct cct tta att cct     2304
 Gly Gln Asp Ile Lys Gln Ser Phe Phe Lys Val Pro Pro Leu Ile Pro
         755                 760                 765

 aag act gat tca gac cct gaa cat cgc cga gtt tcg gct caa ctt gac     2352
 Lys Thr Asp Ser Asp Pro Glu His Arg Arg Val Ser Ala Gln Leu Asp
     770                 775                 780

 gat aat gtg gat gac aat att cca ctt agg gta atg ctg ctt ctc atg     2400
 Asp Asn Val Asp Asp Asn Ile Pro Leu Arg Val Met Leu Leu Leu Met
 785                 790                 795                 800

 gat gaa gta ttc gac tta aaa gaa aga aat cag tgg ttg cga agg aat     2448
 Asp Glu Val Phe Asp Leu Lys Glu Arg Asn Gln Trp Leu Arg Arg Asn
                 805                 810                 815

 atc aaa aac cta ctt caa cag ctt att aga gct aca tat ggc gat act     2496
 Ile Lys Asn Leu Leu Gln Gln Leu Ile Arg Ala Thr Tyr Gly Asp Thr
             820                 825                 830

 att aat aga aaa ata gtt gac cat gtt gac tgg atg act tca cct gaa     2544
 Ile Asn Arg Lys Ile Val Asp His Val Asp Trp Met Thr Ser Pro Glu
         835                 840                 845

 caa gta gcc gac tca gtg aaa cgt ttc aga gat gca ttt tgg cca aat     2592
 Gln Val Ala Asp Ser Val Lys Arg Phe Arg Asp Ala Phe Trp Pro Asn
     850                 855                 860

 ggc att tta gca gag gct gtt cca tgc aga gat aaa agt att cga atg     2640
 Gly Ile Leu Ala Glu Ala Val Pro Cys Arg Asp Lys Ser Ile Arg Met
 865                 870                 875                 880

 aga aca aga gta gca gga aaa acg aaa tta ctt gca att atg cca ggt     2688
 Arg Thr Arg Val Ala Gly Lys Thr Lys Leu Leu Ala Ile Met Pro Gly
                 885                 890                 895

 gag tga gcatgtatag ttaaaaatct ttataatttg tcattcttct gagtttttag      2744
 Glu 






      <210> 405
      <211> 7233
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2661)

      <400> 405
  atg tgg aaa aag gat aat aaa aca caa agg aat aag agt tgt ata act      48
  Met Trp Lys Lys Asp Asn Lys Thr Gln Arg Asn Lys Ser Cys Ile Thr
    1               5                  10                  15

 ctg agg gac gta aaa gaa gaa tgt aga ttt atg ggg gta tgt ttt atc       96
 Leu Arg Asp Val Lys Glu Glu Cys Arg Phe Met Gly Val Cys Phe Ile
              20                  25                  30

 cct tat ggt atc ccc act acc ttg agc tgt gct tgg cac gta gga agc      144
 Pro Tyr Gly Ile Pro Thr Thr Leu Ser Cys Ala Trp His Val Gly Ser
          35                  40                  45

 aat gac tgg ggt tta gtg gtt act ctc ctg ttt gga aaa aca aac tca      192
 Asn Asp Trp Gly Leu Val Val Thr Leu Leu Phe Gly Lys Thr Asn Ser
      50                  55                  60

 gag aag tac cta gaa cag tgt gaa cac tca ttt ctt cct cca aca tca      240
 Glu Lys Tyr Leu Glu Gln Cys Glu His Ser Phe Leu Pro Pro Thr Ser
  65                  70                  75                  80

 cct ggg gtt cct aag tgc tta gaa gaa atg aaa cgg gaa gcc agg act      288
 Pro Gly Val Pro Lys Cys Leu Glu Glu Met Lys Arg Glu Ala Arg Thr
                  85                  90                  95

 att aag att gat aga aga ttg acg ggt gcc aat ata att gat gaa cct      336
 Ile Lys Ile Asp Arg Arg Leu Thr Gly Ala Asn Ile Ile Asp Glu Pro
             100                 105                 110

 ctc cag caa gtt atc cag ttt tcc ttg agg gat tat gtc cag tat tgg      384
 Leu Gln Gln Val Ile Gln Phe Ser Leu Arg Asp Tyr Val Gln Tyr Trp
         115                 120                 125

 tat tat aca cta agc gat gat gaa tct ttt ctt ctt gaa att agg cag      432
 Tyr Tyr Thr Leu Ser Asp Asp Glu Ser Phe Leu Leu Glu Ile Arg Gln
     130                 135                 140

 act ctt caa aac gca ctc att cag ttt gct act agg tca aaa gaa ata      480
 Thr Leu Gln Asn Ala Leu Ile Gln Phe Ala Thr Arg Ser Lys Glu Ile
 145                 150                 155                 160

 gac tgg caa cct tat ttt act aca cgc att gta gat gac ttt ggc aca      528
 Asp Trp Gln Pro Tyr Phe Thr Thr Arg Ile Val Asp Asp Phe Gly Thr
                 165                 170                 175

 cac tta cga gta ttc aga aag gct caa cag aaa ata aca gag aaa gat      576
 His Leu Arg Val Phe Arg Lys Ala Gln Gln Lys Ile Thr Glu Lys Asp
             180                 185                 190

 gat caa gtg aaa ggt aca gca gaa gat ctt gta gat acc ttc ttt gaa      624
 Asp Gln Val Lys Gly Thr Ala Glu Asp Leu Val Asp Thr Phe Phe Glu
         195                 200                 205

 gtt gaa gtt gaa atg gag aag gag gtt tgc cgt gat cta gtg tgc act      672
 Val Glu Val Glu Met Glu Lys Glu Val Cys Arg Asp Leu Val Cys Thr
     210                 215                 220

 tcc ccc aaa gat gaa gaa gga ttc cta agg gat ttg tgt gag gtc tta      720
 Ser Pro Lys Asp Glu Glu Gly Phe Leu Arg Asp Leu Cys Glu Val Leu
 225                 230                 235                 240

 cta tat tta ttg cta cct cct gga gat ttc cag aac aag atc atg cga      768
 Leu Tyr Leu Leu Leu Pro Pro Gly Asp Phe Gln Asn Lys Ile Met Arg
                 245                 250                 255

 tac ttt gtc agg gaa atc ctt gca cga gga att ctt ctt cca tta ata      816
 Tyr Phe Val Arg Glu Ile Leu Ala Arg Gly Ile Leu Leu Pro Leu Ile
             260                 265                 270

 aat caa ctc agt gat cct gat tat att aat cag tat gtc ata tgg atg      864
 Asn Gln Leu Ser Asp Pro Asp Tyr Ile Asn Gln Tyr Val Ile Trp Met
         275                 280                 285

 atc cgt gat tct aac tgc aac tat gag gcc ttt atg aac att att aaa      912
 Ile Arg Asp Ser Asn Cys Asn Tyr Glu Ala Phe Met Asn Ile Ile Lys
     290                 295                 300

 ttg agt gac aat att gga gag cta gaa gca gtc aga gat aag gca gca      960
 Leu Ser Asp Asn Ile Gly Glu Leu Glu Ala Val Arg Asp Lys Ala Ala
 305                 310                 315                 320

 gaa gaa tta cag tat ctt aga tct cta gat aca gct ggt gat gat atc     1008
 Glu Glu Leu Gln Tyr Leu Arg Ser Leu Asp Thr Ala Gly Asp Asp Ile
                 325                 330                 335

 aac act atc aaa aat caa ata aat agc tta cta ttc gta aag aag gta     1056
 Asn Thr Ile Lys Asn Gln Ile Asn Ser Leu Leu Phe Val Lys Lys Val
             340                 345                 350

 tgt gac tca aga ata cag cga ttg cag tca ggc aaa gaa ata aat act     1104
 Cys Asp Ser Arg Ile Gln Arg Leu Gln Ser Gly Lys Glu Ile Asn Thr
         355                 360                 365

 gtg aaa ctt gca gca aac ttt ggg aaa ctt tgc aca gtc ccc ctg gac     1152
 Val Lys Leu Ala Ala Asn Phe Gly Lys Leu Cys Thr Val Pro Leu Asp
     370                 375                 380

 agc att ctt gta gac aat gtt gca cta caa ttt ttt atg gat tac atg     1200
 Ser Ile Leu Val Asp Asn Val Ala Leu Gln Phe Phe Met Asp Tyr Met
 385                 390                 395                 400

 cag caa act gga ggt caa gca cat cta ttc ttt tgg atg aca gtg gaa     1248
 Gln Gln Thr Gly Gly Gln Ala His Leu Phe Phe Trp Met Thr Val Glu
                 405                 410                 415

 gga tac cgg gtt acc gcc caa cag cag cta gaa gtt tta tta agt cgt     1296
 Gly Tyr Arg Val Thr Ala Gln Gln Gln Leu Glu Val Leu Leu Ser Arg
             420                 425                 430

 cag aga gat gga aaa cat caa acc aac caa acc aaa ggt ctt tta aga     1344
 Gln Arg Asp Gly Lys His Gln Thr Asn Gln Thr Lys Gly Leu Leu Arg
         435                 440                 445

 gca gct gct gtt gga att tat gaa cag tat tta tca gaa aag gca tct     1392
 Ala Ala Ala Val Gly Ile Tyr Glu Gln Tyr Leu Ser Glu Lys Ala Ser
     450                 455                 460

 cca aga gtt act gtt gat gac tat tta gta gca aaa tta gca gat act     1440
 Pro Arg Val Thr Val Asp Asp Tyr Leu Val Ala Lys Leu Ala Asp Thr
 465                 470                 475                 480

 ttg aat cat gaa gat cca acc cct gaa atc ttt gat gac att caa aga     1488
 Leu Asn His Glu Asp Pro Thr Pro Glu Ile Phe Asp Asp Ile Gln Arg
                 485                 490                 495

 aag gta tat gaa ttg atg cta cga gat gaa aga ttt tat cct tcc ttc     1536
 Lys Val Tyr Glu Leu Met Leu Arg Asp Glu Arg Phe Tyr Pro Ser Phe
             500                 505                 510

 aga cag aat gca ctt tat gtg cgc atg tta gct gag ctt gac atg tta     1584
 Arg Gln Asn Ala Leu Tyr Val Arg Met Leu Ala Glu Leu Asp Met Leu
         515                 520                 525

 aaa gat cct agt ttc aga gga tcc gat gat ggg gat gga gaa tct ttt     1632
 Lys Asp Pro Ser Phe Arg Gly Ser Asp Asp Gly Asp Gly Glu Ser Phe
     530                 535                 540

 aat ggg tct cct aca gga agc ata aat ttg tct tta gat gac ctt tca     1680
 Asn Gly Ser Pro Thr Gly Ser Ile Asn Leu Ser Leu Asp Asp Leu Ser
 545                 550                 555                 560

 aat gtt tct tct gat gac tca gta caa ctt cat gcc tac att tca gac     1728
 Asn Val Ser Ser Asp Asp Ser Val Gln Leu His Ala Tyr Ile Ser Asp
                 565                 570                 575

 aca ggc gtt tgt aat gat cat ggc aag aca tat gca tta tat gcc atc     1776
 Thr Gly Val Cys Asn Asp His Gly Lys Thr Tyr Ala Leu Tyr Ala Ile
             580                 585                 590

 act gta cac cgg cgc aac cta aac agt gag gag atg tgg aaa acc tat     1824
 Thr Val His Arg Arg Asn Leu Asn Ser Glu Glu Met Trp Lys Thr Tyr
         595                 600                 605

 cgt cgt tat agt gac ttc cat gac ttc cac atg aga atc act gaa cag     1872
 Arg Arg Tyr Ser Asp Phe His Asp Phe His Met Arg Ile Thr Glu Gln
     610                 615                 620

 ttt gaa agt ctc tca agc ata ttg aaa ctt cct gga aaa aag act ttt     1920
 Phe Glu Ser Leu Ser Ser Ile Leu Lys Leu Pro Gly Lys Lys Thr Phe
 625                 630                 635                 640

 aat aat atg gat aga gat ttt tta gaa aag aga aaa aag gat cta aat     1968
 Asn Asn Met Asp Arg Asp Phe Leu Glu Lys Arg Lys Lys Asp Leu Asn
                 645                 650                 655

 gca tat ttg cag tta ctg tta gct cct gaa atg atg aag gca tcc cca     2016
 Ala Tyr Leu Gln Leu Leu Leu Ala Pro Glu Met Met Lys Ala Ser Pro
             660                 665                 670

 gct tta gct cac tat gtg tat gat ttc ctt gag aac aaa gcc tac agt     2064
 Ala Leu Ala His Tyr Val Tyr Asp Phe Leu Glu Asn Lys Ala Tyr Ser
         675                 680                 685

 aaa gga aaa ggg gat ttt gct cgc aag atg gac act ttt gta aat cca     2112
 Lys Gly Lys Gly Asp Phe Ala Arg Lys Met Asp Thr Phe Val Asn Pro
     690                 695                 700

 ctt cgc aat tca atg agg aat gtt tca aat gca gtt aaa tcc ctt cct     2160
 Leu Arg Asn Ser Met Arg Asn Val Ser Asn Ala Val Lys Ser Leu Pro
 705                 710                 715                 720

 gat agc ttg gca gag gga atg act aaa atg tca gac aac atg ggc aaa     2208
 Asp Ser Leu Ala Glu Gly Met Thr Lys Met Ser Asp Asn Met Gly Lys
                 725                 730                 735

 atg tca gaa aga tta ggt caa gac ata aag caa tca ttt ttt aag gtg     2256
 Met Ser Glu Arg Leu Gly Gln Asp Ile Lys Gln Ser Phe Phe Lys Val
             740                 745                 750

 cct cct tta att cct aag act gat tca gac cct gaa cat cgc cga gtt     2304
 Pro Pro Leu Ile Pro Lys Thr Asp Ser Asp Pro Glu His Arg Arg Val
         755                 760                 765

 tcg gct caa ctt gac gat aat gtg gat gac aat att cca ctt agg gta     2352
 Ser Ala Gln Leu Asp Asp Asn Val Asp Asp Asn Ile Pro Leu Arg Val
     770                 775                 780

 atg ctg ctt ctc atg gat gaa gta ttc gac tta aaa gaa aga aat cag     2400
 Met Leu Leu Leu Met Asp Glu Val Phe Asp Leu Lys Glu Arg Asn Gln
 785                 790                 795                 800

 tgg ttg cga agg aat atc aaa aac cta ctt caa cag ctt att aga gct     2448
 Trp Leu Arg Arg Asn Ile Lys Asn Leu Leu Gln Gln Leu Ile Arg Ala
                 805                 810                 815

 aca tat ggc gat act att aat aga aaa ata gtt gac cat gtt gac tgg     2496
 Thr Tyr Gly Asp Thr Ile Asn Arg Lys Ile Val Asp His Val Asp Trp
             820                 825                 830

 atg act tca cct gaa caa gta gcc gac tca gtg aaa cgt ttc aga gat     2544
 Met Thr Ser Pro Glu Gln Val Ala Asp Ser Val Lys Arg Phe Arg Asp
         835                 840                 845

 gca ttt tgg cca aat ggc att tta gca gag gct gtt cca tgc aga gat     2592
 Ala Phe Trp Pro Asn Gly Ile Leu Ala Glu Ala Val Pro Cys Arg Asp
     850                 855                 860

 aaa agt att cga atg aga aca aga gta gca gga aaa acg aaa tta ctt     2640
 Lys Ser Ile Arg Met Arg Thr Arg Val Ala Gly Lys Thr Lys Leu Leu
 865                 870                 875                 880

 gca att atg cca ggt gag tga gc atgtatagtt aaaaatcttt ataatttgtc     2693
 Ala Ile Met Pro Gly Glu 
                 885

 attcttctga gtttttagca ttcatcatgc cagtgtaact gccttttgat tataacaact   2753

 accttttgat ggcttaatac atatcaggca ctgtactagg catttctcat atgttcttaa   2813

 tcagtcctca tgacagtact gtaaagctaa ggactgttaa catcaccgct ttatatgtga   2873

 ggaaacggaa gctcagagag gttaaataac ctatccaagg tttatagcta ctaagcaaca   2933

 gttggtattc tgacttggct ttaagtgatg tgaaagctta tgcttttagc cacttcgctc   2993

 tgctgccttg aaacatattg ggagttaagt taaataaata aaatacatga caggtgaaag   3053

 ggctaataaa atataaagta tgaatttttc aggaagaata tttgttgtac ttaggaaaac   3113

 aagttatttc aaaaactcca tttacataga aagaactgat tggctgatta ttaatcttta   3173

 ttacttaaaa tacaatccca aacaaagtat acttagtagc attttgttgg tctgattttg   3233

 gttgcttcat tagggtatag ctatctcact accttagatt tactttttct cgtttttctt   3293

 ctttcaatca gagaagttat ataatgtaaa aagcaattta atgcggctgg gaggtggtga   3353

 tggttgtttt gccccttgtt aatgagtatc tttgaaaatg cctgcatgtc ttttctctgt   3413

 attttaattc tggatgtaga gaatgaacag acatatttgt acattcttta atatcacaca   3473

 ataccaattt ttttctctaa ttttgttttc ttacctgtat tttctctata aattttaatg   3533

 accagccttc tcttctgtca attaaattaa aaatttgcca caattttaat tcttacctat   3593

 ataccgtttc atttgctgat aaaaaagcaa attatagaaa tgacatttta gaaaaataag   3653

 aaacaattgc ttaggatatt atttaatata ctattatagt aaacctgatt gtgctatatg   3713

 gactgactca gttatctagc tggaagaaat ctttattcac taaatattta ttgaaagtta   3773

 ttatgtgcca ggtgctgttc tttgcactta tgtttgcctt cttggagctt actttccagt   3833

 agaaatagag agactcaaaa acacacagaa caaataaatg gaacgtagtt tgttagataa   3893

 gtggtaagta ctaaagagaa agatactgca ggaaaatgga atagatagtg tcagatgagt   3953

 tgcagtttta gatggggtgg ccagggcagg cctcactgag atgatgatgg tggtgtgaag   4013

 atctgaagga agtgagggta aatatgaaag catataaatt tatatataca taatccttgc   4073

 ctatttttta gtaaattctc aaaatttttg ctttaaatta tatcgtaccc ctagttagat   4133

 aaagactttt tggaaattgc atgtttcttt ccaaagcagc aaaataatat ctatattatc   4193

 agtattatga ataattattt gtaattatga ataagaatat gaataattaa taatcataca   4253

 tgttggtctc ataacttggt gttatttatg attaaacacc aaatttgctc actcttagtc   4313

 acagcaccat cggttttcta ttttctttgc tttcttcact ttgaatttaa ataaaattca   4373

 acccaacttg tactatccct atttcttgag catgctttgt ttttctagtt actgcttatt   4433

 tgctcattca tgttcttttc accaaggcta atccttcatc tcattgcacc tatcaaaatc   4493

 ctgcccaagt agaaagtctc ctttacctgc cacttcctta aagggaactt ttctttgtta   4553

 tcgcatctga aagtctcccc actaccaata ttcttatact tttagcattt ttatggtata   4613

 gttactatgc caggggtttt tgtagatcag ggattaattt ttttttttcc tgtgttccaa   4673

 tgaaacttta ttcaccatca tggattagtt tgtttcctta cagcatttgt cactattcat   4733

 taggcctact aagaatattt gtataatatt acaaagttta cagatcactt tttacattat   4793

 ttcattaaag acttataaat ccttataagg atgttattat aaatcctcct tttcagatga   4853

 gaaaagagag tcagggtggt gggtaagtat cacatgggta ttaagggaca tgtttgtaat   4913

 catagtttgg gatctttgag actgtttttt attttttatc tcttacacct gtgctatatt   4973

 gtctcccagt agcttttgca ttaagtgcgt aaatagatgc atgcatgcaa agatgcatat   5033

 taagtttcag ctatagtaca tagctgaaat gcattaactg gttacctact gttcatcagt   5093

 tactctgctg tgtaccttaa tttaagaaca tttaagagtt taggccttgt gtttcctttg   5153

 aataattatg tgtgttttcc tccacttcat ttagatgagc tgaagcacat tattggggct   5213

 gagacaacac ggaaaggtat tcttcgtgtt tttgaaatgt ttcagcacaa ccaattaaat   5273

 aggagaatgg tttatgtctt cttggaaggc tttttagaaa ccttatttcc acagtataaa   5333

 ttccgtgaac ttttcaacaa actgcattca cggtcaaagc agatgcagaa atataaacag   5393

 aaacttcaaa ctactcaagc gccttctttg cagaaaaggt gacactccac tctatgaagc   5453

 tggtgttcat tttgtccagg actaatggta tggacagatc ttctggggct taactcaaat   5513

 actgttgtgt ctgcaccagt cttttagtgt ctcaaaatag attattaata catccataag   5573

 tctgtggttc ttctcattct catctataat ccaccactac caagagagat ttctgtgtct   5633

 taaatgattt ggtgcatatt ttgcaacatt gagagaaaac tgcccccatc tcaagcaaga   5693

 atggcgttgg tttcttccat ttcaaactaa tcagcattct ccagcaatga caaagtgcca   5753

 gagtgtatat atgaaagcta aggaaagcac aaaacaatgg ttcagagata aattggctaa   5813

 tttgtttaac agttggagac tgtgcaatgt acgacttgga ggagtttgtt tggcataatg   5873

 attttgtagg tctgtcagca ttttgatata ttgtggatta gccaggtgaa tgatccttga   5933

 aacatctctt tcaggtctgg agaaagagac agaatgccct taaagtgtga aataacctta   5993

 tacctgaatt acagttttgt gatataaaat aaagctgagt ataaaataaa accaatcaaa   6053

 cacagaattt gattggattt gttattcatt ggtatacaac aatttttatt cttatgtgtg   6113

 ctttaagggc tgtgttttgc tcttagggta ctcaatttta tgtttccttt tggcattctt   6173

 tgtgcaaaaa gaagcatgtg gtggctctca tttaaatttc aaaattatta gttttatctt   6233

 taacagatta ctgattatac agaagatata atttattgga agaactgcca aatacatttt   6293

 gtccttctaa aaatatggaa atttaaatag tagtctggaa agttaccata tgataatttt   6353

 taattgtgtg atctagacat gccttaggta actgcagaaa tagcaaatta aatgattaat   6413

 gagcttatta gtcatagtaa acatacagat tcctaattct atgacagtgt acatatatga   6473

 aaataaatga tgaaaaaaga actataatat ttttaaaaat atgcttttat ttatatttca   6533

 cataatgtaa agttctacaa aataaagcta gtaggcaaga cccctcagtg tataccttta   6593

 aacccataaa ttaattttat atcaataaaa taaaatactt tctctagttt tggagcttct   6653

 gtatttccta tagttttctg actgtccatt ttatccatct tagaagtatt cacatccctt   6713

 ctatgcagga tttctgcata gttttaaata ctttcattgc ctaagggttt gggtgtgtca   6773

 gctttttttg ttttaaaaat atttaacact aaaaccttaa aataatgaag ctacttatca   6833

 gaccactgag ccaagatcct ggtattaaaa gaaagtctgg gtgcttaaga taaagggaca   6893

 gagtattggt atcccagtta tttgggagct ttaagattgg aacaagatat cactgtcttg   6953

 ttttcactta gatcctactt acaaagtgag ggttattaac agaataaagc cttcctttaa   7013

 agctttataa taatcatatt tattaataat gctgttgtgc atacttatag tatgcatata   7073

 ttcagcatat gttgcatgtc ttcagaatta cataaaatga aatccctttc attgcaactt   7133

 gcaagagaga aaagatcctt agtggctctg gtggaagaaa tagtatttct tcttctcagg   7193

 gtgtctccct gccttggccc ctccctgagc cccaggcttt                         7233




      <210> 406
      <211> 3300
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (254)..(2527)

      <400> 406
 gcaaggcctg gctgaccgac tctggcgagt cgctgccctc tcggagcgcc gtagttctga     60

 gatgcagttc acaccgcggc ccttcttggg gcccactcca aggctactgg atcaggaccc    120

 ccagtctggg gccgggcatt ttcaaattaa tcagcaggct ctagcacccc gcctccatga    180

 cgtcaacgcg ccgcgccacc gggctgcgtc atctcggcgc gccgctgcca gggctgtaca    240

 cctgctggct gcc   atg gct gag gtg ggc cgt acc ggg atc agc tac cca     289
                  Met Ala Glu Val Gly Arg Thr Gly Ile Ser Tyr Pro
                    1               5                  10

 ggc gcg ctt ctc cca cag ggc ttc tgg gct gcg gtc gaa gtg tgg ctg      337
 Gly Ala Leu Leu Pro Gln Gly Phe Trp Ala Ala Val Glu Val Trp Leu
          15                  20                  25

 gag agg ccg cag gtg gca aac aaa cgg ctt tgc ggc gcc cgc ctg gag      385
 Glu Arg Pro Gln Val Ala Asn Lys Arg Leu Cys Gly Ala Arg Leu Glu
      30                  35                  40

 gcc cgc tgg agc gcc gcc ctg ccc tgc gcg gag gcc cgc ggc ccc ggg      433
 Ala Arg Trp Ser Ala Ala Leu Pro Cys Ala Glu Ala Arg Gly Pro Gly
  45                  50                  55                  60

 act agc gca ggc tcg gag cag aag gag cgg ggt ccg gga ccc ggc cag      481
 Thr Ser Ala Gly Ser Glu Gln Lys Glu Arg Gly Pro Gly Pro Gly Gln
                  65                  70                  75

 ggt tcc ccc gga ggg ggc ccg ggt ccc agg tcg cta tca gga ccc gag      529
 Gly Ser Pro Gly Gly Gly Pro Gly Pro Arg Ser Leu Ser Gly Pro Glu
              80                  85                  90

 cag ggc acg gca tgt tgc gaa ctt gag gag gcc cag ggc cag tgc cag      577
 Gln Gly Thr Ala Cys Cys Glu Leu Glu Glu Ala Gln Gly Gln Cys Gln
          95                 100                 105

 caa gag gag gca cag agg gaa gcc gcc tca gtg ccc ctg agg gac tcc      625
 Gln Glu Glu Ala Gln Arg Glu Ala Ala Ser Val Pro Leu Arg Asp Ser
     110                 115                 120

 ggg cac ccc ggc cat gct gaa gga agg gag ggc gac ttc ccc gcc gca      673
 Gly His Pro Gly His Ala Glu Gly Arg Glu Gly Asp Phe Pro Ala Ala
 125                 130                 135                 140

 gat ctg gat tcg ctt tgg gag gat ttc tcc caa agt ctc gcc cgt ggc      721
 Asp Leu Asp Ser Leu Trp Glu Asp Phe Ser Gln Ser Leu Ala Arg Gly
                 145                 150                 155

 aat tcg gag ttg ctg gcc ttc ctc acc agc tcc ggg gcg gga tcg cag      769
 Asn Ser Glu Leu Leu Ala Phe Leu Thr Ser Ser Gly Ala Gly Ser Gln
             160                 165                 170

 cca gag gcg cag cgt gag ctc gac gtg gtt ctc aga acc gtc atc ccg      817
 Pro Glu Ala Gln Arg Glu Leu Asp Val Val Leu Arg Thr Val Ile Pro
         175                 180                 185

 aaa act agc cca cat tgc ccc ctt aca act ccc agg agg gaa ata gtc      865
 Lys Thr Ser Pro His Cys Pro Leu Thr Thr Pro Arg Arg Glu Ile Val
     190                 195                 200

 gtg caa gat gtc ctc aat gga acc ata acg ttt ttg cct ttg gaa gaa      913
 Val Gln Asp Val Leu Asn Gly Thr Ile Thr Phe Leu Pro Leu Glu Glu
 205                 210                 215                 220

 gat gat gag ggg aac cta aag gtt aag atg agc aat gtg tat caa att      961
 Asp Asp Glu Gly Asn Leu Lys Val Lys Met Ser Asn Val Tyr Gln Ile
                 225                 230                 235

 cag ctc agt cat agc aaa gaa gaa tgg ttc ata tct gtt tta att ttc     1009
 Gln Leu Ser His Ser Lys Glu Glu Trp Phe Ile Ser Val Leu Ile Phe
             240                 245                 250

 tgt cca gaa aga tgg cat tca gat gga atc gtg tat ccc aaa ccc acg     1057
 Cys Pro Glu Arg Trp His Ser Asp Gly Ile Val Tyr Pro Lys Pro Thr
         255                 260                 265

 tgg ctt gga gaa gag ttg ctg gcc aag ttg gcc aag tgg tct gta gag     1105
 Trp Leu Gly Glu Glu Leu Leu Ala Lys Leu Ala Lys Trp Ser Val Glu
     270                 275                 280

 aac aag aag agt gac ttt aaa agc acc ctt tcc ctc atc tcc att atg     1153
 Asn Lys Lys Ser Asp Phe Lys Ser Thr Leu Ser Leu Ile Ser Ile Met
 285                 290                 295                 300

 aag tat agc aag gct tac cag gat ctt aaa gag aag tat aag gaa atg     1201
 Lys Tyr Ser Lys Ala Tyr Gln Asp Leu Lys Glu Lys Tyr Lys Glu Met
                 305                 310                 315

 gtt aag gtg tgg cct gaa gtc act gat cct gag aag ttc gtg tat gaa     1249
 Val Lys Val Trp Pro Glu Val Thr Asp Pro Glu Lys Phe Val Tyr Glu
             320                 325                 330

 gat gtg gct atc gca gca tac ctg ctg att cta tgg gaa gaa gaa agg     1297
 Asp Val Ala Ile Ala Ala Tyr Leu Leu Ile Leu Trp Glu Glu Glu Arg
         335                 340                 345

 gct gag agg gga cta act gcc agg cag tcc ttt gtg gac ctg gga tgt     1345
 Ala Glu Arg Gly Leu Thr Ala Arg Gln Ser Phe Val Asp Leu Gly Cys
     350                 355                 360

 gga aat ggc ctc ctg gtc cac atc ctg agc agt gag ggg cat cca ggc     1393
 Gly Asn Gly Leu Leu Val His Ile Leu Ser Ser Glu Gly His Pro Gly
 365                 370                 375                 380

 aga ggg att gat gtc cga aga aga aaa atc tgg gac atg tat gga cca     1441
 Arg Gly Ile Asp Val Arg Arg Arg Lys Ile Trp Asp Met Tyr Gly Pro
                 385                 390                 395

 caa act cag tta gag gaa gat gca atc aca ccc aat gat aag acc ctt     1489
 Gln Thr Gln Leu Glu Glu Asp Ala Ile Thr Pro Asn Asp Lys Thr Leu
             400                 405                 410

 ttc cct gat gtt gat tgg tta atc ggt aac cat tct gat gaa ctc aca     1537
 Phe Pro Asp Val Asp Trp Leu Ile Gly Asn His Ser Asp Glu Leu Thr
         415                 420                 425

 cca tgg ata cct gtc att gca gcc agg tct tcc tac aat tgc cgc ttc     1585
 Pro Trp Ile Pro Val Ile Ala Ala Arg Ser Ser Tyr Asn Cys Arg Phe
     430                 435                 440

 ttt gtc ctc ccc tgc tgc ttc ttt gac ttc att gga aga tac tcc cgg     1633
 Phe Val Leu Pro Cys Cys Phe Phe Asp Phe Ile Gly Arg Tyr Ser Arg
 445                 450                 455                 460

 agg cag agt aag aag act cag tac cgg gaa tac ctt gac ttc att aaa     1681
 Arg Gln Ser Lys Lys Thr Gln Tyr Arg Glu Tyr Leu Asp Phe Ile Lys
                 465                 470                 475

 gaa gtg ggc ttc acc tgt ggg ttt cac gtg gac gaa gac tgc ctc agg     1729
 Glu Val Gly Phe Thr Cys Gly Phe His Val Asp Glu Asp Cys Leu Arg
             480                 485                 490

 att cct tca acc aaa aga gtc tgt ctc gtt gga aaa tcc aga aca tac     1777
 Ile Pro Ser Thr Lys Arg Val Cys Leu Val Gly Lys Ser Arg Thr Tyr
         495                 500                 505

 cct tcc tcc aga gaa gct tcc gtg gat gaa aag agg act cag tac att     1825
 Pro Ser Ser Arg Glu Ala Ser Val Asp Glu Lys Arg Thr Gln Tyr Ile
     510                 515                 520

 aag agc agg cgg ggc tgc cct gta agc cca cct ggc tgg gag ctt tcc     1873
 Lys Ser Arg Arg Gly Cys Pro Val Ser Pro Pro Gly Trp Glu Leu Ser
 525                 530                 535                 540

 cct tct cca cgc tgg gtt gct gct ggc agt gct ggt cac tgt gac ggt     1921
 Pro Ser Pro Arg Trp Val Ala Ala Gly Ser Ala Gly His Cys Asp Gly
                 545                 550                 555

 cag caa gct ctg gac gcc agg gtc ggg tgt gta acc agg gcc tgg gcc     1969
 Gln Gln Ala Leu Asp Ala Arg Val Gly Cys Val Thr Arg Ala Trp Ala
             560                 565                 570

 gct gag cat gga gca ggg ccc cag gct gaa gga ccc tgg cta cct gga     2017
 Ala Glu His Gly Ala Gly Pro Gln Ala Glu Gly Pro Trp Leu Pro Gly
         575                 580                 585

 ttt cat ccc aga gaa aag gct gag cgt gtg agg aac tgt gcc gcc ctg     2065
 Phe His Pro Arg Glu Lys Ala Glu Arg Val Arg Asn Cys Ala Ala Leu
     590                 595                 600

 cca cga gat ttt att gac caa gtg gtt ttg caa gta gcg aat tta ctg     2113
 Pro Arg Asp Phe Ile Asp Gln Val Val Leu Gln Val Ala Asn Leu Leu
 605                 610                 615                 620

 tta ggt gga aag caa tta aac aca aga agt tct cga aat ggg agt ttg     2161
 Leu Gly Gly Lys Gln Leu Asn Thr Arg Ser Ser Arg Asn Gly Ser Leu
                 625                 630                 635

 aag acc tgg aat ggg gga gag agc cta tct ctg gca gaa gta gcc aac     2209
 Lys Thr Trp Asn Gly Gly Glu Ser Leu Ser Leu Ala Glu Val Ala Asn
             640                 645                 650

 gag ctg gac acg gag acc ctg cgg agg ctg aag cgg gag tgt ggg ggc     2257
 Glu Leu Asp Thr Glu Thr Leu Arg Arg Leu Lys Arg Glu Cys Gly Gly
         655                 660                 665

 ctg cag acg ctg ctc cgg aac agc cac cag gtg ttc caa gtt gtg aat     2305
 Leu Gln Thr Leu Leu Arg Asn Ser His Gln Val Phe Gln Val Val Asn
     670                 675                 680

 ggg aga gtt cac atc cgc gac tgg cga gag gag aca ctg tgg aag aca     2353
 Gly Arg Val His Ile Arg Asp Trp Arg Glu Glu Thr Leu Trp Lys Thr
 685                 690                 695                 700

 aag caa ccg gaa gcg aaa cag aga ctg ctc tct gaa gcc tgc aaa acc     2401
 Lys Gln Pro Glu Ala Lys Gln Arg Leu Leu Ser Glu Ala Cys Lys Thr
                 705                 710                 715

 cgc ctc tgc tgg ttc ttc atg cat cac cct gat ggc tgc gct ctg tcc     2449
 Arg Leu Cys Trp Phe Phe Met His His Pro Asp Gly Cys Ala Leu Ser
             720                 725                 730

 acg gac tgc tgc ccg ttt gcc cat ggg cct gcg gag ctg cgg cca ccc     2497
 Thr Asp Cys Cys Pro Phe Ala His Gly Pro Ala Glu Leu Arg Pro Pro
         735                 740                 745

 cgg acc acc ccg agg aag aag att tca tga g ctgcatcctt gccagccgag     2548
 Arg Thr Thr Pro Arg Lys Lys Ile Ser 
     750                 755

 gcctggttgg ggaggccaaa ccaaggagag cttccccagc agtcgtcagt gctgtggtct   2608

 ctgctctggc tgtgtttcag cccacctcct cccagctttc tccacatcct cacagtgatg   2668

 aaccgtattt cataaacatc acacgccaga gaagccacag ttactcggaa gcccccagct   2728

 gactgcctgg cttgtttcag atgcagccgc ttgaaacgtg cgcagcatct tcatatcata   2788

 aagattgtgc acggatcctt acaatgtctc ctgggggaga gcggctgagg ctgccttgca   2848

 caggcccttc ccagggcgct gtccgacgcc tgccccacca tgtccacatc tgtgaagagg   2908

 atggggctcc tcgagaagta agaccgtatc tgccagcgtt tctcaccaca ctggagagca   2968

 gctgctctgg agcagggatc caccagattg gtatttttaa aaaaggtgtc aggcttgcta   3028

 tgttgaggtt gtttttagag ttacagagaa taaaaacact cataatttcc tgacatgggc   3088

 cactctaagt ggcatgaaaa aaaaatccta agtgaattgt tgacagggct ttaaaaatgt   3148

 aaatatcaca gatgacaaag gtaagaccta caccctcctc cctcctccat gagaccctct   3208

 ccccagaaat actgcagcag tcctttttag tccttccaga aaaaaaaatc ctgattgttt   3268

 ctctttattt ttatgaacga ttaggtttag tt                                 3300




      <210> 407
      <211> 1106
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (396)..(773)

      <400> 407
 aaacttaagc ttggtaccga gctcggatcc actagtccag tgtggtggaa ttcctccacc     60

 agaagcctgg ccagacgtga aagaacaaag agcatcatct ctctgacaga gagtttgtgt    120

 tcaaagaacc tcagcaggta gtacgtagag ctcctgagcc acgagtgatt gacagagagg    180

 gtgtgtatga aatcagcctg tcacccacag gtgtatctag ggtctgtttg tatcctggct    240

 ttgttgacgt gaaagaagct gactggatat tggaacagct ttgtcaagat gttccctgga    300

 aacagaggac cggcatcaga gaggatataa cttatcagca accaagactt acagcatggt    360

 atggagaact tccttacact tattcaagaa tcact   atg gaa cca aat cct cac     413
                                          Met Glu Pro Asn Pro His
                                            1               5

 tgg cac cct gtg ctg cgc aca cta aag aac cgc att gaa gag aac act      461
 Trp His Pro Val Leu Arg Thr Leu Lys Asn Arg Ile Glu Glu Asn Thr
              10                  15                  20

 ggc cac acc ttc aac tcc tta ctc tgc aat ctt tat cgc aat gag aag      509
 Gly His Thr Phe Asn Ser Leu Leu Cys Asn Leu Tyr Arg Asn Glu Lys
          25                  30                  35

 gac agc gtg gac tgg cac agt gat gat gaa ccc tca cta ggg agg tgc      557
 Asp Ser Val Asp Trp His Ser Asp Asp Glu Pro Ser Leu Gly Arg Cys
      40                  45                  50

 ccc att att gct tca cta agt ttt ggt gcc aca cgc aca ttt gag atg      605
 Pro Ile Ile Ala Ser Leu Ser Phe Gly Ala Thr Arg Thr Phe Glu Met
  55                  60                  65                  70

 aga aag aag cca cca cca gaa gag aat gga gac tac aca tat gtg gaa      653
 Arg Lys Lys Pro Pro Pro Glu Glu Asn Gly Asp Tyr Thr Tyr Val Glu
                  75                  80                  85

 aga gtg aag ata ccc ttg gat cat ggt acc ttg tta atc atg gaa gga      701
 Arg Val Lys Ile Pro Leu Asp His Gly Thr Leu Leu Ile Met Glu Gly
              90                  95                 100

 gcg aca caa gct gac tgg cag agt tat gtg tat ttc cat tta gca tcg      749
 Ala Thr Gln Ala Asp Trp Gln Ser Tyr Val Tyr Phe His Leu Ala Ser
         105                 110                 115

 agt gcc caa aga ata cca ctc tag agaaccgaga gtgaacctga cctttcggac     803
 Ser Ala Gln Arg Ile Pro Leu 
     120                 125

 agtctatcca gaccctcgag gggcaccctg gtgacgtcag agctttgaga gagaagcttc    863

 actgaaacgg agcaaacctt ccactgagaa gccacttcaa gaggctggtg ctgctagatc    923

 tcatgatgtg gctgttggga agatggtggg gtttgtttgc cagcttggag tcctattaaa    983

 tgaaagccag caactcatgt tggtaatagg tctactgtgg gaacagttat ccctaaccac   1043

 agctcaaaat cgctatcatc tttaggcaaa ttaaaatcta tgtggcagtg aaaaaaaaaa   1103

 aaa                                                                 1106




      <210> 408
      <211> 2091
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (287)..(1513)

      <400> 408
 catttttttt ttttctcctg ttcaggttga ggctactaag gccagaaagc agattttcac     60

 ttgggaagag acgacccgta gtatgggatg tggtatgata ccagcaactg gtctattata    120

 tcatttaaac cacatggcta tctaaagagg tatttggcta ttataaataa aatagtgatg    180

 aacacgtgta caggtgtttg tacggacata agttgtcatt tctcttgagt aaatacctaa    240

 aagtgggctt gctggagttt tactaccctt ggatgctgct gttgac   atg gaa aag     295
                                                      Met Glu Lys
                                                        1

 att gag gaa caa ttt gct aat ctg cac att gtt aaa tgt tcc tta gga      343
 Ile Glu Glu Gln Phe Ala Asn Leu His Ile Val Lys Cys Ser Leu Gly
       5                  10                  15

 acc aaa gag ccc act tac ctt ctt ggt ata gac aca tca aag act gtc      391
 Thr Lys Glu Pro Thr Tyr Leu Leu Gly Ile Asp Thr Ser Lys Thr Val
  20                  25                  30                  35

 caa gca gga aag gaa aac ttg gtt gct gtt tta tgt tct aat gga tca      439
 Gln Ala Gly Lys Glu Asn Leu Val Ala Val Leu Cys Ser Asn Gly Ser
                  40                  45                  50

 atc aga ata tat gat aaa gaa agg tta aat gta cta cga gaa ttt agt      487
 Ile Arg Ile Tyr Asp Lys Glu Arg Leu Asn Val Leu Arg Glu Phe Ser
              55                  60                  65

 gga tat cct gga ctt ctt aat gga gtc aga ttt gca aat tcc tgt gac      535
 Gly Tyr Pro Gly Leu Leu Asn Gly Val Arg Phe Ala Asn Ser Cys Asp
          70                  75                  80

 agt gta tat tca gca tgt act gat ggc act gtg aaa tgc tgg gat gct      583
 Ser Val Tyr Ser Ala Cys Thr Asp Gly Thr Val Lys Cys Trp Asp Ala
      85                  90                  95

 cga gta gcc aga gaa aaa cct gtt cag ctc ttc aag ggt tac cct tcc      631
 Arg Val Ala Arg Glu Lys Pro Val Gln Leu Phe Lys Gly Tyr Pro Ser
 100                 105                 110                 115

 aat att ttt atc agt ttt gat att aat tgt aat gat cat att att tgt      679
 Asn Ile Phe Ile Ser Phe Asp Ile Asn Cys Asn Asp His Ile Ile Cys
                 120                 125                 130

 gct ggt aca gaa aaa gtt gat gat gat gca ttg ttg gtg ttt tgg gat      727
 Ala Gly Thr Glu Lys Val Asp Asp Asp Ala Leu Leu Val Phe Trp Asp
             135                 140                 145

 gca agg atg aat tct cag aat tta tct aca act aaa gac tca ctt ggt      775
 Ala Arg Met Asn Ser Gln Asn Leu Ser Thr Thr Lys Asp Ser Leu Gly
         150                 155                 160

 gca tat tca gag aca cat agt gat gat gtc act caa gta cgt ttc cat      823
 Ala Tyr Ser Glu Thr His Ser Asp Asp Val Thr Gln Val Arg Phe His
     165                 170                 175

 ccc agc aat ccc aac atg gta gtc tca ggt tca tct gat ggc ctg gta      871
 Pro Ser Asn Pro Asn Met Val Val Ser Gly Ser Ser Asp Gly Leu Val
 180                 185                 190                 195

 aat gta ttt gat att aat att gat aat gag gag gat gca ctg gtt aca      919
 Asn Val Phe Asp Ile Asn Ile Asp Asn Glu Glu Asp Ala Leu Val Thr
                 200                 205                 210

 acc tgt aac tca att tca tca gta agc tgt att ggt tgg tct ggg aaa      967
 Thr Cys Asn Ser Ile Ser Ser Val Ser Cys Ile Gly Trp Ser Gly Lys
             215                 220                 225

 ggt tat aaa cag att tac tgc atg aca cat gat gaa gga ttt tat tgg     1015
 Gly Tyr Lys Gln Ile Tyr Cys Met Thr His Asp Glu Gly Phe Tyr Trp
         230                 235                 240

 tgg gat ctt aat cat ctg gac act gat gaa cca gtt aca cgt ttg aac     1063
 Trp Asp Leu Asn His Leu Asp Thr Asp Glu Pro Val Thr Arg Leu Asn
     245                 250                 255

 atc cag gat gtc aga gaa gta gtt aac atg aaa gaa gat gct ttg gac     1111
 Ile Gln Asp Val Arg Glu Val Val Asn Met Lys Glu Asp Ala Leu Asp
 260                 265                 270                 275

 tat ttg att ggt ggc cta tat cat gaa aag aca gac aca ttg cat gtt     1159
 Tyr Leu Ile Gly Gly Leu Tyr His Glu Lys Thr Asp Thr Leu His Val
                 280                 285                 290

 att gga gga aca aac aaa gga agg att cat ttg atg aac tgc agc atg     1207
 Ile Gly Gly Thr Asn Lys Gly Arg Ile His Leu Met Asn Cys Ser Met
             295                 300                 305

 tca gga ctg acc cat gtg act agc ctt cag gga ggg cat gct gct aca     1255
 Ser Gly Leu Thr His Val Thr Ser Leu Gln Gly Gly His Ala Ala Thr
         310                 315                 320

 gtc cgt tct ttc tgt tgg aat gtg caa gat gat tct ttg ttg act gga     1303
 Val Arg Ser Phe Cys Trp Asn Val Gln Asp Asp Ser Leu Leu Thr Gly
     325                 330                 335

 gga gaa gat gca cag ttg tta ctt tgg aaa cct gga gct ata gag aag     1351
 Gly Glu Asp Ala Gln Leu Leu Leu Trp Lys Pro Gly Ala Ile Glu Lys
 340                 345                 350                 355

 acc ttt aca aag aaa gag agt atg aaa ata gca tcc tct gtg cac caa     1399
 Thr Phe Thr Lys Lys Glu Ser Met Lys Ile Ala Ser Ser Val His Gln
                 360                 365                 370

 cga gta cga gtt cat agt aat gat tct tat aaa gaa gga aaa agc agc     1447
 Arg Val Arg Val His Ser Asn Asp Ser Tyr Lys Glu Gly Lys Ser Ser
             375                 380                 385

 tct ttg gag ctg gcc tta gct cgg tcc gct tca tcc gtg gaa ccc aaa     1495
 Ser Leu Glu Leu Ala Leu Ala Arg Ser Ala Ser Ser Val Glu Pro Lys
         390                 395                 400

 gca tcc aca aga atc tag aagcaa aaatagcccg cttccaccag cgggaggatg     1549
 Ala Ser Thr Arg Ile 
     405

 ccatcctcta tcccagctgt tgtgacgcca acgccggcct ctttgaggtc ctgctgagac   1609

 ccgaggacgc agtcctgtcg gacgagctga actgtgcctc catcatccac ggcatctgcc   1669

 tgtgcaaggc ccacaagtac cactattgcc acctggacgt ggcctaccta gaaaccaagc   1729

 ttcaggaggc ccagaagcat cggctgttcc tggtggccac cgatggggcc ttttccatgg   1789

 atggcgacat cgtgcccctg cagaagatct gccgcctcgc ctctagatat ggcgccctgg   1849

 tctttgtgga tgaatgccat gccactggtt tcctgggact cacaggacag ggcacagatg   1909

 agctgctggg tgtgatgggc caggtcacca tcatcaactc caccctgggg aaggccctgg   1969

 gtggtgcatc agggggctac acgacagggc ctgggcccct ggtgtcactg ctgctgccca   2029

 gccctatctc ttctccaaca gtctgccacc tgctgttgtt ggctgcacct ctaaggccct   2089

 ag                                                                  2091




      <210> 409
      <211> 3572
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (582)..(3572)

      <400> 409
 agattatgag gaacaggcct cattatttta atacattttt tttctaatta taaaaactgc     60

 catcagagca agaagatcca tgaggacaca tttctcttag tttgtttagc ttacttgatg    120

 tttgctctgc aataacacca gctagcatga ggtaattcac tgtaattaga gctgccagtg    180

 acagttgggc aattcagaga gaggcatttg tcaacaggtt ctactttaga caaggagagg    240

 gagaaaaacg ggcatctcct gcagggatgg cttgcctgct cccaaatgga gtaggcaaag    300

 ttcgtcttca tcctcccatt accacattgg gagctgcttt ccttgccttg gctttagatc    360

 ctttctgcgt tctgcctcct ggttacccca gaatgttcca tgtggcctca tatcttcttc    420

 tacgtttccc agtacaggcc cagactttga gtctctcttt aaatagaagg cagcataggc    480

 ttcttctcta ggccataaat ctacgagtga gatccaaatc tgtctcttct tctgttgttt    540

 ttaacaatca ttttcaagct gtgaaaaagg gctcctatga c    atg gtg tcg act     593
                                                  Met Val Ser Thr
                                                    1

 ctg atc aaa cat aac act agc cta gac cag ccc tgt gtc aag cga tgg      641
 Leu Ile Lys His Asn Thr Ser Leu Asp Gln Pro Cys Val Lys Arg Trp
   5                  10                  15                  20

 tca gca atg cat gaa gca gcc aag caa ggc cga aaa gat atc gta gct      689
 Ser Ala Met His Glu Ala Ala Lys Gln Gly Arg Lys Asp Ile Val Ala
                  25                  30                  35

 ctg ctg ctg aaa cat gga ggc aat gtc cac ctg aga gat gga ttt gga      737
 Leu Leu Leu Lys His Gly Gly Asn Val His Leu Arg Asp Gly Phe Gly
              40                  45                  50

 gtc aca cca cta ggc gtc gct gcc gag tat ggt cac tgt gac gtg tta      785
 Val Thr Pro Leu Gly Val Ala Ala Glu Tyr Gly His Cys Asp Val Leu
          55                  60                  65

 gaa cat cta atc cac aaa ggt ggt gat gtg ctt gct ttg gcg gat gat      833
 Glu His Leu Ile His Lys Gly Gly Asp Val Leu Ala Leu Ala Asp Asp
      70                  75                  80

 ggg gcg tcg gtg ctg ttt gag gca gca gga ggt ggc aat ccc gac tgc      881
 Gly Ala Ser Val Leu Phe Glu Ala Ala Gly Gly Gly Asn Pro Asp Cys
  85                  90                  95                 100

 att tcc ctc ctg ctg gaa tat gga gga agc gga aat gta cct aac cga      929
 Ile Ser Leu Leu Leu Glu Tyr Gly Gly Ser Gly Asn Val Pro Asn Arg
                 105                 110                 115

 gca gga cat ctt cct ata cac cga gct gcc tat gag ggg cat tat ctt      977
 Ala Gly His Leu Pro Ile His Arg Ala Ala Tyr Glu Gly His Tyr Leu
             120                 125                 130

 gca ctg aaa tat ctt atc cca gta aca tct aaa aat gca att cgg aaa     1025
 Ala Leu Lys Tyr Leu Ile Pro Val Thr Ser Lys Asn Ala Ile Arg Lys
         135                 140                 145

 agt ggg cta aca cca att cac tca gca gca gat gga caa aat gca cag     1073
 Ser Gly Leu Thr Pro Ile His Ser Ala Ala Asp Gly Gln Asn Ala Gln
     150                 155                 160

 tgt cta gaa ctg ctc att gaa aat ggt ttt gat gtc aac act cta ctt     1121
 Cys Leu Glu Leu Leu Ile Glu Asn Gly Phe Asp Val Asn Thr Leu Leu
 165                 170                 175                 180

 gct gac cac att tcc cag agc tat gac gat gag agg aag act gcg ctg     1169
 Ala Asp His Ile Ser Gln Ser Tyr Asp Asp Glu Arg Lys Thr Ala Leu
                 185                 190                 195

 tat ttt ggc gtt tct aat aat gac gtt cat tgc aca gaa gtc ctt ctg     1217
 Tyr Phe Gly Val Ser Asn Asn Asp Val His Cys Thr Glu Val Leu Leu
             200                 205                 210

 gct gca ggt gca gac cca aac tta gat ccc ctc aac tgt cta ctt gtt     1265
 Ala Ala Gly Ala Asp Pro Asn Leu Asp Pro Leu Asn Cys Leu Leu Val
         215                 220                 225

 gca gtg agg gcc aat aat tat gaa att gtc agg ctg ctt ctc tcc cat     1313
 Ala Val Arg Ala Asn Asn Tyr Glu Ile Val Arg Leu Leu Leu Ser His
     230                 235                 240

 gga gct aat gtc aat tgt tat ttt atg cat gtg aat gac act cgt ttc     1361
 Gly Ala Asn Val Asn Cys Tyr Phe Met His Val Asn Asp Thr Arg Phe
 245                 250                 255                 260

 ccc agt gtc att caa tat gct cta aac gac gag gta atg ctg agg cta     1409
 Pro Ser Val Ile Gln Tyr Ala Leu Asn Asp Glu Val Met Leu Arg Leu
                 265                 270                 275

 ttg ctg aat aat ggc tat caa gtg gag atg tgc ttt gac tgc atg cat     1457
 Leu Leu Asn Asn Gly Tyr Gln Val Glu Met Cys Phe Asp Cys Met His
             280                 285                 290

 ggt gac atc ttt gga aat tca ttt gtg tgg tca gag ata cag gaa gag     1505
 Gly Asp Ile Phe Gly Asn Ser Phe Val Trp Ser Glu Ile Gln Glu Glu
         295                 300                 305

 gtg ctg cca gga tgg aca tct tgt gta ata aaa gat aac ccg gac ctg     1553
 Val Leu Pro Gly Trp Thr Ser Cys Val Ile Lys Asp Asn Pro Asp Leu
     310                 315                 320

 gag tct tct aaa gtg aca gtt gtc atg acc ctg agg agg gaa cca tac     1601
 Glu Ser Ser Lys Val Thr Val Val Met Thr Leu Arg Arg Glu Pro Tyr
 325                 330                 335                 340

 caa gga gat cgc tgt ctt ggg tgc tca cct tcc aca tca ttc ttc tta     1649
 Gln Gly Asp Arg Cys Leu Gly Cys Ser Pro Ser Thr Ser Phe Phe Leu
                 345                 350                 355

 ata cta cag cga aca act ctg tcc aaa ctt gtc aga cca aca ctc ggg     1697
 Ile Leu Gln Arg Thr Thr Leu Ser Lys Leu Val Arg Pro Thr Leu Gly
             360                 365                 370

 gtt tca gga cag aga aaa ggc ctt tcc agc gaa gac cta ttt gaa aca     1745
 Val Ser Gly Gln Arg Lys Gly Leu Ser Ser Glu Asp Leu Phe Glu Thr
         375                 380                 385

 gct cct tct ggg tct gac aaa gca ggg acc atg tct acc ttt ggc tac     1793
 Ala Pro Ser Gly Ser Asp Lys Ala Gly Thr Met Ser Thr Phe Gly Tyr
     390                 395                 400

 cga aga gga ctc agt aaa tac gaa tcc atc gac gag gat gaa ctc ctc     1841
 Arg Arg Gly Leu Ser Lys Tyr Glu Ser Ile Asp Glu Asp Glu Leu Leu
 405                 410                 415                 420

 gcc tcc ctg tca gcc gag gag ctg aag gag cta gag aga gag ttg gaa     1889
 Ala Ser Leu Ser Ala Glu Glu Leu Lys Glu Leu Glu Arg Glu Leu Glu
                 425                 430                 435

 gac att gaa cct gac cgc aac ctt ccc gtg ggg cta agg caa aag agc     1937
 Asp Ile Glu Pro Asp Arg Asn Leu Pro Val Gly Leu Arg Gln Lys Ser
             440                 445                 450

 ctg aca gag aaa acc ccc aca ggg aca ttc agc aga gag gca ctg atg     1985
 Leu Thr Glu Lys Thr Pro Thr Gly Thr Phe Ser Arg Glu Ala Leu Met
         455                 460                 465

 gcc tat tgg gaa aag gag tcc caa aaa ctc ttg gag aag gag agg ctg     2033
 Ala Tyr Trp Glu Lys Glu Ser Gln Lys Leu Leu Glu Lys Glu Arg Leu
     470                 475                 480

 ggg gaa tgt gga aag gtt gca gaa gac aaa gag gaa agt gaa gaa gag     2081
 Gly Glu Cys Gly Lys Val Ala Glu Asp Lys Glu Glu Ser Glu Glu Glu
 485                 490                 495                 500

 ctt atc ttt act gaa agt aac agt gag gtt tct gag gaa gtg tat aca     2129
 Leu Ile Phe Thr Glu Ser Asn Ser Glu Val Ser Glu Glu Val Tyr Thr
                 505                 510                 515

 gag gag gag gag gag gag tcc cag gag gaa gag gag gaa gaa gac agt     2177
 Glu Glu Glu Glu Glu Glu Ser Gln Glu Glu Glu Glu Glu Glu Asp Ser
             520                 525                 530

 gac gaa gag gaa aga aca att gaa act gca aaa ggg att aat gga act     2225
 Asp Glu Glu Glu Arg Thr Ile Glu Thr Ala Lys Gly Ile Asn Gly Thr
         535                 540                 545

 gta aat tat gat agt gtc aat tct gac aac tct aag cca aag ata ttt     2273
 Val Asn Tyr Asp Ser Val Asn Ser Asp Asn Ser Lys Pro Lys Ile Phe
     550                 555                 560

 aaa agt caa ata gag aac ata aat ttg acc aat ggc agc aat ggg agg     2321
 Lys Ser Gln Ile Glu Asn Ile Asn Leu Thr Asn Gly Ser Asn Gly Arg
 565                 570                 575                 580

 aac aca gag tcc cca gct gcc att cac cct tgt gga aat cct aca gtg     2369
 Asn Thr Glu Ser Pro Ala Ala Ile His Pro Cys Gly Asn Pro Thr Val
                 585                 590                 595

 att gag gac gct ttg gac aag att aaa agc aat gac cct gac acc aca     2417
 Ile Glu Asp Ala Leu Asp Lys Ile Lys Ser Asn Asp Pro Asp Thr Thr
             600                 605                 610

 gaa gtc aat ttg aac aac att gag aac atc aca aca cag acc ctt acc     2465
 Glu Val Asn Leu Asn Asn Ile Glu Asn Ile Thr Thr Gln Thr Leu Thr
         615                 620                 625

 cgc ttt gct gaa gcc ctc aag gac aac act gtg gtg aag acg ttc agt     2513
 Arg Phe Ala Glu Ala Leu Lys Asp Asn Thr Val Val Lys Thr Phe Ser
     630                 635                 640

 ctg gcc aac acg cat gcc gac gac agt gca gcc atg gcc att gca gag     2561
 Leu Ala Asn Thr His Ala Asp Asp Ser Ala Ala Met Ala Ile Ala Glu
 645                 650                 655                 660

 atg ctc aaa gtc aat gag cac atc acc aac gta aac gtc gag tcc aac     2609
 Met Leu Lys Val Asn Glu His Ile Thr Asn Val Asn Val Glu Ser Asn
                 665                 670                 675

 ttc ata acg gga aag ggg atc ctg gcc atc atg aga gct ctc cag cac     2657
 Phe Ile Thr Gly Lys Gly Ile Leu Ala Ile Met Arg Ala Leu Gln His
             680                 685                 690

 aac acg gtg ctc acg gag ctg cgt ttc cat aac cag agg cac atc atg     2705
 Asn Thr Val Leu Thr Glu Leu Arg Phe His Asn Gln Arg His Ile Met
         695                 700                 705

 ggc agc cag gtg gaa atg gag att gtc aag ctg ctg aag gag aac acg     2753
 Gly Ser Gln Val Glu Met Glu Ile Val Lys Leu Leu Lys Glu Asn Thr
     710                 715                 720

 acg ctg ctg agg ctg gga tac cat ttt gaa ctc cca gga cca aga atg     2801
 Thr Leu Leu Arg Leu Gly Tyr His Phe Glu Leu Pro Gly Pro Arg Met
 725                 730                 735                 740

 agc atg acg agc att ttg aca aga aat atg gat aaa cag agg caa aaa     2849
 Ser Met Thr Ser Ile Leu Thr Arg Asn Met Asp Lys Gln Arg Gln Lys
                 745                 750                 755

 cgt ttg cag gag caa aaa cag cag gag gga tac gat gga gga ccc aat     2897
 Arg Leu Gln Glu Gln Lys Gln Gln Glu Gly Tyr Asp Gly Gly Pro Asn
             760                 765                 770

 ctt agg acc aaa gtc tgg caa aga gga aca cct agc tct tca cct tat     2945
 Leu Arg Thr Lys Val Trp Gln Arg Gly Thr Pro Ser Ser Ser Pro Tyr
         775                 780                 785

 gta tct ccc agg cac tca ccc tgg tca tcc cca aaa ctc ccc aaa aaa     2993
 Val Ser Pro Arg His Ser Pro Trp Ser Ser Pro Lys Leu Pro Lys Lys
     790                 795                 800

 gtc cag act gtg agg agc cgt cct ctg tct cct gtg gcc aca cct cct     3041
 Val Gln Thr Val Arg Ser Arg Pro Leu Ser Pro Val Ala Thr Pro Pro
 805                 810                 815                 820

 cct cct ccc cct cct cct cct cct ccc cct cct tct tcc caa agg ctg     3089
 Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ser Ser Gln Arg Leu
                 825                 830                 835

 cca cca cct cct cct cct ccc cct cct cca ctc cca gag aaa aag ctc     3137
 Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Glu Lys Lys Leu
             840                 845                 850

 att acc aga aac att gca gaa gtc atc aaa caa cag gag agt gcc caa     3185
 Ile Thr Arg Asn Ile Ala Glu Val Ile Lys Gln Gln Glu Ser Ala Gln
         855                 860                 865

 cgg gca tta caa aat gga caa aaa aag aaa aaa ggg aaa aag gtc aag     3233
 Arg Ala Leu Gln Asn Gly Gln Lys Lys Lys Lys Gly Lys Lys Val Lys
     870                 875                 880

 aaa cag cca aac agt att cta aag gaa ata aaa aat tct ctg agg tca     3281
 Lys Gln Pro Asn Ser Ile Leu Lys Glu Ile Lys Asn Ser Leu Arg Ser
 885                 890                 895                 900

 gtg caa gag aag aaa atg gaa gac agt tcc cga cct tct acc cca cag     3329
 Val Gln Glu Lys Lys Met Glu Asp Ser Ser Arg Pro Ser Thr Pro Gln
                 905                 910                 915

 aga tca gct cat gag aat ctc atg gaa gca att cgg gga agc agc ata     3377
 Arg Ser Ala His Glu Asn Leu Met Glu Ala Ile Arg Gly Ser Ser Ile
             920                 925                 930

 aaa cag cta aag cgg atg aca gaa gtg ccc tgt gat gac caa atg ctc     3425
 Lys Gln Leu Lys Arg Met Thr Glu Val Pro Cys Asp Asp Gln Met Leu
         935                 940                 945

 ggg caa tgt agg gtg act gcc gcc aat gag cca aaa tac aat cac atg     3473
 Gly Gln Cys Arg Val Thr Ala Ala Asn Glu Pro Lys Tyr Asn His Met
     950                 955                 960

 cat cag agt cag agg ctg gct cct caa aac aag cca gct ttt ctg gtt     3521
 His Gln Ser Gln Arg Leu Ala Pro Gln Asn Lys Pro Ala Phe Leu Val
 965                 970                 975                 980

 aga gat gga cat agg atg ttg gcg gca tct atc aac acc cag atg ata     3569
 Arg Asp Gly His Arg Met Leu Ala Ala Ser Ile Asn Thr Gln Met Ile
                 985                 990                 995

 tga                                                                 3572
 






      <210> 410
      <211> 1293
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (503)..(817)

      <400> 410
 tcagctcagg tatctcctca tggaaaccct tcttcacatc cagaggtggt cggcttcctt     60

 ctctattcta accctgggct ttgtacacag gtctgcatcc cctcctagca tctgtgagct    120

 tctctcaggg aaaagctcat tgatctgcat ccccaagacc tgctggggaa gaatctatcc    180

 atctaaactc gctttaattt gacaaatgaa tcagttaaga gtaggaaagc tgcctatggg    240

 cactgctcaa tgcaacgtga gcaacaaagg gagacagaac tgaggccaga aaggtgaggg    300

 gggacagagg ctggcaggga ggggagcttg tcagtgcaga ctccaggaag aatctataca    360

 gaaagttact gagcggcctg agtcccccaa gtgagggctc gggacaatct cccgcctggg    420

 tgagagaata gggagaccct gaaacgtctc tgcagcctcg ggctgctcca gaagcgccca    480

 cagctgcagg gttttggtgt gg atg gga cct gct gac agg gat gcg gtg gga     532
                          Met Gly Pro Ala Asp Arg Asp Ala Val Gly
                            1               5                  10

 aga gcc cct cgg cgc ccg ttc tcc cag gct tcc cct tgg cca agg gtg      580
 Arg Ala Pro Arg Arg Pro Phe Ser Gln Ala Ser Pro Trp Pro Arg Val
                  15                  20                  25

 ctc cta gca cag ggc cat gaa agt aag atg aag agg ctt gtt ttt ctc      628
 Leu Leu Ala Gln Gly His Glu Ser Lys Met Lys Arg Leu Val Phe Leu
              30                  35                  40

 cta gat acc agc ggg caa gca gaa aac aag agg ctc aag agg ggc agc      676
 Leu Asp Thr Ser Gly Gln Ala Glu Asn Lys Arg Leu Lys Arg Gly Ser
          45                  50                  55

 ccc cgc ata gag gag atg cga gct ctg cgc tct gcc agg ctg cca agg      724
 Pro Arg Ile Glu Glu Met Arg Ala Leu Arg Ser Ala Arg Leu Pro Arg
      60                  65                  70

 cag ctg aca cac aag agt tca gga cca aac tgc aca aag tat ttc gtg      772
 Gln Leu Thr His Lys Ser Ser Gly Pro Asn Cys Thr Lys Tyr Phe Val
  75                  80                  85                  90

 aga tca ccc aac acc aat ttc ttc acc act gct cat gtg agg tga agc      820
 Arg Ser Pro Asn Thr Asn Phe Phe Thr Thr Ala His Val Arg 
                  95                 100

 agcagctaac cctagaaaaa aaggactcag cccagggcac tgaggacgca cctgataaca    880

 gcagcctgga gctcctagca gataccagcg ggcaagcaga aaacaagagg ctcaagaggg    940

 gcagcccccg catagaggag atgcgagctc tgcgctctgc cagggccccg agcccgtcag   1000

 aggccgcccc gcgccgcccg gaagccaccg cggcccccct cactcctaga ggaagggagc   1060

 accgcgaggc tcacggcagg gccctggcgc cgggcagggc gagcctcgga agccgcctgg   1120

 aggacgtgct gtggctgcag gaggtctcca acctgtcaga gtggctgagt cccagccctg   1180

 ggccctgagc cgggtcccct tccgcaagcg cccaccgatc cggaggctgc gggcagccgt   1240

 tatcccgtgg tttaataaag ctgccgcgcg ctcaccaaaa aaaaaaaaaa aaa          1293




      <210> 411
      <211> 852
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (111)..(500)

      <220>
      <221> misc_feature
      <222> (1)...(852)
      <223> n = a,t,c or g

      <400> 411
 agtngtttaa taactgtatt tgagtattat cgttttcctt tgtattttat acatttggaa     60

 acattattct gaggattgtc cacaggctta accagacagc caaaggcacc   atg gcc     116
                                                          Met Ala
                                                            1

 cca aaa tgg tta caa gcc atg gtc caa aga gac cac tgg agg gag ccc      164
 Pro Lys Trp Leu Gln Ala Met Val Gln Arg Asp His Trp Arg Glu Pro
           5                  10                  15

 tgg agg ctg ctt tct ctg cat gtt cca gct cac ctt ggg gcc gac ctt      212
 Trp Arg Leu Leu Ser Leu His Val Pro Ala His Leu Gly Ala Asp Leu
      20                  25                  30

 ccc act tta gtt acc cgt gtt tac att tct ctt tat gcc agt cac cag      260
 Pro Thr Leu Val Thr Arg Val Tyr Ile Ser Leu Tyr Ala Ser His Gln
  35                  40                  45                  50

 ctg acc ctc cta cgt ggc cct ctt ctt aac tca tgg ttt ctc tac cca      308
 Leu Thr Leu Leu Arg Gly Pro Leu Leu Asn Ser Trp Phe Leu Tyr Pro
                  55                  60                  65

 tca ggc aat gtt tac aag ttt cag act ggt tcc cga ttt cat gca ata      356
 Ser Gly Asn Val Tyr Lys Phe Gln Thr Gly Ser Arg Phe His Ala Ile
              70                  75                  80

 ctg tgg cac aag cat ttg gat gat gca tgt aaa agc aac agg cct cag      404
 Leu Trp His Lys His Leu Asp Asp Ala Cys Lys Ser Asn Arg Pro Gln
          85                  90                  95

 gaa gcc gga gca gct cca ggt cca aca gga act gac agc cac gag gtg      452
 Glu Ala Gly Ala Ala Pro Gly Pro Thr Gly Thr Asp Ser His Glu Val
     100                 105                 110

 gac cac ctg gag ggc ggt gcg ggg aag gag gca ggg ccc tgt gcc tga      500
 Asp His Leu Glu Gly Gly Ala Gly Lys Glu Ala Gly Pro Cys Ala 
 115                 120                 125

 agcctgggca ccatggtggc cccagtcagg agcaacagtg gtagccctga gtaaaaccca    560

 ttgtccctct ttggaggagc ggccagagga tgacagcagc cccagcaggc agcagtgcct    620

 gggcaggctg atccagcaga gcactaatgg gtcagtttca tgtattggca gatgtggtgt    680

 agcatggcaa ggctacaagt tttaaggatt tttgtctgat tttcagacct ggaggagggg    740

 atttttcttc ctactttccc ccttttttat ttctaattta ctttcaacca aatattccca    800

 ctatgtgcta tatgtaataa taaaaagttg acaacaactg aaaaaaaaaa aa            852




      <210> 412
      <211> 974
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (398)..(964)

      <400> 412
 gtcttgaata cgttaagaaa gtcttgtttg tgtagaagag tttcaaatca tgtgagtgat     60

 gaagggaccc ttctgttgaa ccttggtgtg cattttaggt ccattttggg tttactcctt    120

 tgtgctgctt catgatgcct taggacaagg acaaggccta ggcctccttg tctcagttcc    180

 ctcctgctct ctctgttgcc ctcctccttc cacctggagc atggcccagc atcaggttgg    240

 cgcatgctgt gatcagctac ctccatgcac cacaccaagc aaagctctct gggtgacaca    300

 gttgccacca ccagggcact gacccttact ctgtgttctc ctagctcctc ctgagggtgc    360

 tgtaggagac atctgcaaaa aagaagatgc tggcaat atg cca tca acc tca gag     415
                                          Met Pro Ser Thr Ser Glu
                                            1               5

 ggg agt att tac cct gaa atg gct cac ttc ctg agg aac aaa ctt gct      463
 Gly Ser Ile Tyr Pro Glu Met Ala His Phe Leu Arg Asn Lys Leu Ala
              10                  15                  20

 gga tct agt gta cgg aaa cct gat tct ggg ttc ctt tgg gaa gga gca      511
 Gly Ser Ser Val Arg Lys Pro Asp Ser Gly Phe Leu Trp Glu Gly Ala
          25                  30                  35

 tta cgg gcc tgg tcc agt atg gtg gca ccc agt ggc agt gtg aac tgt      559
 Leu Arg Ala Trp Ser Ser Met Val Ala Pro Ser Gly Ser Val Asn Cys
      40                  45                  50

 gag gag ttc gcc gag ttc cag gaa tta ctc aag gtg atg agg cct atc      607
 Glu Glu Phe Ala Glu Phe Gln Glu Leu Leu Lys Val Met Arg Pro Ile
  55                  60                  65                  70

 gat gac aga ata gta cat gaa tta aac act aca gtt cca acg cct tcc      655
 Asp Asp Arg Ile Val His Glu Leu Asn Thr Thr Val Pro Thr Pro Ser
                  75                  80                  85

 ttt gca ggg aaa att gat gcc agc caa acc tgt aaa caa ctt tat gag      703
 Phe Ala Gly Lys Ile Asp Ala Ser Gln Thr Cys Lys Gln Leu Tyr Glu
              90                  95                 100

 tct ttg atg gca gct cat gcc agt aga gac aga gtc ata aaa aac tgt      751
 Ser Leu Met Ala Ala His Ala Ser Arg Asp Arg Val Ile Lys Asn Cys
         105                 110                 115

 ata gcc cag act tca gca gta gta aaa aac ctc cga gaa gag aga gaa      799
 Ile Ala Gln Thr Ser Ala Val Val Lys Asn Leu Arg Glu Glu Arg Glu
     120                 125                 130

 aag aat ttg gac gat tta acg tta tta aaa caa ctt aga aaa gag cag      847
 Lys Asn Leu Asp Asp Leu Thr Leu Leu Lys Gln Leu Arg Lys Glu Gln
 135                 140                 145                 150

 aca aag ttg aaa tgg atg cag tca gaa ctg aat gtt gaa gaa gtg gta      895
 Thr Lys Leu Lys Trp Met Gln Ser Glu Leu Asn Val Glu Glu Val Val
                 155                 160                 165

 aat gac agg agc tgg aag gtg ttt aat gaa cgc tgc cga att cac ttc      943
 Asn Asp Arg Ser Trp Lys Val Phe Asn Glu Arg Cys Arg Ile His Phe
             170                 175                 180

 aag cct cca aag aat gaa taa agagagattc                               974
 Lys Pro Pro Lys Asn Glu 
         185





      <210> 413
      <211> 1564
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (24)..(1145)

      <400> 413
 aaaagcggcg cggctcgttc aag    atg gcg gag ctc gac cag ttg cct gac      50
                              Met Ala Glu Leu Asp Gln Leu Pro Asp
                                1               5

 gag agc tct tca gca aaa gcc ctt gtc agt tta aaa gaa gga agc tta       98
 Glu Ser Ser Ser Ala Lys Ala Leu Val Ser Leu Lys Glu Gly Ser Leu
  10                  15                  20                  25

 tct aac acg tgg aat gaa aag tac agt tct tta cag aaa aca cct gtt      146
 Ser Asn Thr Trp Asn Glu Lys Tyr Ser Ser Leu Gln Lys Thr Pro Val
                  30                  35                  40

 tgg aaa ggc agg aat aca agc tct gct gtg gaa atg cct ttc aga aat      194
 Trp Lys Gly Arg Asn Thr Ser Ser Ala Val Glu Met Pro Phe Arg Asn
              45                  50                  55

 tca aaa cga agt cga ctt ttt tct gat gaa gat gat agg caa ata aat      242
 Ser Lys Arg Ser Arg Leu Phe Ser Asp Glu Asp Asp Arg Gln Ile Asn
          60                  65                  70

 aca agg tca cct aaa aga aac cag agg gtt gca atg gtt cca cag aaa      290
 Thr Arg Ser Pro Lys Arg Asn Gln Arg Val Ala Met Val Pro Gln Lys
      75                  80                  85

 ttt aca gca aca atg tca aca cca gat aag aaa gct tca cag aag att      338
 Phe Thr Ala Thr Met Ser Thr Pro Asp Lys Lys Ala Ser Gln Lys Ile
  90                  95                 100                 105

 ggt ttt cga tta cgt aat ctg ctc aag ctt cct aaa gca cat aaa tgg      386
 Gly Phe Arg Leu Arg Asn Leu Leu Lys Leu Pro Lys Ala His Lys Trp
                 110                 115                 120

 tgt ata tac gag tgg ttc tat tca aat ata gat aaa cca ctt ttt gaa      434
 Cys Ile Tyr Glu Trp Phe Tyr Ser Asn Ile Asp Lys Pro Leu Phe Glu
             125                 130                 135

 ggt gat aat gac ttt tgt gta tgt cta aag gaa tct ttt cct aat ttg      482
 Gly Asp Asn Asp Phe Cys Val Cys Leu Lys Glu Ser Phe Pro Asn Leu
         140                 145                 150

 aaa aca aga aag tta aca aga gta gaa tgg gga aaa att cgg cgg ctt      530
 Lys Thr Arg Lys Leu Thr Arg Val Glu Trp Gly Lys Ile Arg Arg Leu
     155                 160                 165

 atg gga aaa cca cgg aga tgt tct tct gca ttt ttt gag gaa gag aga      578
 Met Gly Lys Pro Arg Arg Cys Ser Ser Ala Phe Phe Glu Glu Glu Arg
 170                 175                 180                 185

 tca gca tta aaa cag aaa cgg cag aaa ata agg ctc tta caa caa agg      626
 Ser Ala Leu Lys Gln Lys Arg Gln Lys Ile Arg Leu Leu Gln Gln Arg
                 190                 195                 200

 aaa gtt gca gat gtt tca caa ttc aaa gat ctc cca gat gaa att cct      674
 Lys Val Ala Asp Val Ser Gln Phe Lys Asp Leu Pro Asp Glu Ile Pro
             205                 210                 215

 ttg cct ctg gtt att gga acg aaa gtt aca gca cga tta cgt ggt gtt      722
 Leu Pro Leu Val Ile Gly Thr Lys Val Thr Ala Arg Leu Arg Gly Val
         220                 225                 230

 cat gat ggt ttg ttc act gga caa ata gat gct gtg gat act ctt aat      770
 His Asp Gly Leu Phe Thr Gly Gln Ile Asp Ala Val Asp Thr Leu Asn
     235                 240                 245

 gct act tat aga gta act ttt gat agg aca ggg ctt gga acc cat acc      818
 Ala Thr Tyr Arg Val Thr Phe Asp Arg Thr Gly Leu Gly Thr His Thr
 250                 255                 260                 265

 atc cct gac tat gaa gtt ctc agt aat gaa cct cat gag aca atg cca      866
 Ile Pro Asp Tyr Glu Val Leu Ser Asn Glu Pro His Glu Thr Met Pro
                 270                 275                 280

 att gct gcc ttt gga caa aaa cag cgg cct tct cga ttt ttt atg acc      914
 Ile Ala Ala Phe Gly Gln Lys Gln Arg Pro Ser Arg Phe Phe Met Thr
             285                 290                 295

 cca cca cgg tta cat tat act cct cct ctc cag tca cca att ata gat      962
 Pro Pro Arg Leu His Tyr Thr Pro Pro Leu Gln Ser Pro Ile Ile Asp
         300                 305                 310

 aat gat cct tta tta gga cag tcg ccg tgg aga agt aaa att tct ggc     1010
 Asn Asp Pro Leu Leu Gly Gln Ser Pro Trp Arg Ser Lys Ile Ser Gly
     315                 320                 325

 tct gac act gaa aca tta ggt ggt ttt cca gta gaa ttt ctt atc caa     1058
 Ser Asp Thr Glu Thr Leu Gly Gly Phe Pro Val Glu Phe Leu Ile Gln
 330                 335                 340                 345

 gtg acc aga tta tca aaa att ctc atg att aaa aag gaa cat atc aag     1106
 Val Thr Arg Leu Ser Lys Ile Leu Met Ile Lys Lys Glu His Ile Lys
                 350                 355                 360

 aaa tta agg gaa atg aac aca gaa gca gaa aaa ttg tga cagaactcaa      1155
 Lys Leu Arg Glu Met Asn Thr Glu Ala Glu Lys Leu 
             365                 370

 acgtggcatt tactcaagtt aaatggagag aaagaagcac ttctctaaag aatttgaatg   1215

 tactatttgg ggaaagttaa ggtttttttc tgctttttca ccggattgct atgagattgt   1275

 cccaacacgg gggtccagct gagagatcag cgaaggtatt aacccgtgtg tagcggcgaa   1335

 acacccggca cagtgtccgc gcgacatcct cagcggagaa cccgtcttta caggggcact   1395

 gggcgacagc aattcagatc gcgactggtg accaattgtg ccagcggacg cccctgagca   1455

 accaactcag agtaacgaaa catgatcacg agcactaaca aacgataagt gaagcgaacg   1515

 gcccacggct gcaacgactg cttcctcatc atacatcttt cattatgag               1564




      <210> 414
      <211> 3297
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (367)..(1941)

      <400> 414
 agcgggcggg cgcccccgcc gcccgcgccg cagtccgcat ccacccggcg cggtcagccc     60

 cggctgcggc tccagctccg cgctccgctc ttctctcccg agccggatcg cgggagcgag    120

 caggggaggg gaccgcagcc ggcgcccgag ggcaggagga gtccgcaggc gggcccctgg    180

 ctgcggtagc agctgccggt ggcagggagg tgccagcccg cgcggggtgg cccagccgcg    240

 ggagcggtgg ggcgggggcc gcggccgccg gccccaggga gagatcgcgg gcagcatggc    300

 ggggctgcgg gccagggggg cccggggccg gggctgctgg cgctctccgc gctcggcttc    360

 tgcctc   atg ctg caa gtc agc gct aag agg ccc ccc aag acg ccc ccc     408
          Met Leu Gln Val Ser Ala Lys Arg Pro Pro Lys Thr Pro Pro
            1               5                  10

 tgc ccg ccc agc tgc tct tgc acc agg gac acc tgc ttc tgc gtg gac      456
 Cys Pro Pro Ser Cys Ser Cys Thr Arg Asp Thr Cys Phe Cys Val Asp
  15                  20                  25                  30

 tca aag gcg gtg ccc agg aac ctg ccc tcg gag gtc atc tcc ctg acc      504
 Ser Lys Ala Val Pro Arg Asn Leu Pro Ser Glu Val Ile Ser Leu Thr
                  35                  40                  45

 ctg gtg aat gcc gcc ttc tca gag atc cag gat gga gcg ttc tcc cac      552
 Leu Val Asn Ala Ala Phe Ser Glu Ile Gln Asp Gly Ala Phe Ser His
              50                  55                  60

 ctc ccg ctg ctg cag ttc ttg tta ctc aac tcc aac aag ttt aca ctg      600
 Leu Pro Leu Leu Gln Phe Leu Leu Leu Asn Ser Asn Lys Phe Thr Leu
          65                  70                  75

 att gga gac aac gcc ttc aca gga ctg tcg cac ctg cag tat ctc ttc      648
 Ile Gly Asp Asn Ala Phe Thr Gly Leu Ser His Leu Gln Tyr Leu Phe
      80                  85                  90

 att gag aac aat gac atc tgg gca cta tcc aag ttc acc ttc cga gga      696
 Ile Glu Asn Asn Asp Ile Trp Ala Leu Ser Lys Phe Thr Phe Arg Gly
  95                 100                 105                 110

 ctc aag tcc ttg act cac ctc tcg ctg gcc aac aat aac ctg cag aca      744
 Leu Lys Ser Leu Thr His Leu Ser Leu Ala Asn Asn Asn Leu Gln Thr
                 115                 120                 125

 ctg ccc aga gac atc ttc cgg ccc ctg gac atc ctg aat gac ttg gac      792
 Leu Pro Arg Asp Ile Phe Arg Pro Leu Asp Ile Leu Asn Asp Leu Asp
             130                 135                 140

 ctg cgg ggc aac tca ctc aac tgt gac tgc aag gtg aag tgg ttg gtg      840
 Leu Arg Gly Asn Ser Leu Asn Cys Asp Cys Lys Val Lys Trp Leu Val
         145                 150                 155

 gag tgg ctg gca cac acc aac acc acg gtg gca ccc atc tac tgc gcc      888
 Glu Trp Leu Ala His Thr Asn Thr Thr Val Ala Pro Ile Tyr Cys Ala
     160                 165                 170

 agc ccg ccc cgc ttc cag gag cac aag gtg cag gac ctg ccg ctg cgg      936
 Ser Pro Pro Arg Phe Gln Glu His Lys Val Gln Asp Leu Pro Leu Arg
 175                 180                 185                 190

 gag ttc gat tgc atc acc aca gat ttt gtg ttg tac cag acc ctg gcc      984
 Glu Phe Asp Cys Ile Thr Thr Asp Phe Val Leu Tyr Gln Thr Leu Ala
                 195                 200                 205

 ttc cca gca gtg tcg gct gag ccc ttc ctc tac tcc agt gac ctc tat     1032
 Phe Pro Ala Val Ser Ala Glu Pro Phe Leu Tyr Ser Ser Asp Leu Tyr
             210                 215                 220

 ttg gct ctg gcc cag cca gga gtc agt gcc tgc acc atc ctg aag tgg     1080
 Leu Ala Leu Ala Gln Pro Gly Val Ser Ala Cys Thr Ile Leu Lys Trp
         225                 230                 235

 gac tat gtt gag cgg cag ctt cga gac tat gat aga atc cca gcc ccc     1128
 Asp Tyr Val Glu Arg Gln Leu Arg Asp Tyr Asp Arg Ile Pro Ala Pro
     240                 245                 250

 tct gca gtg cac tgc aag ccg atg gtg gtg gac agc cag ctg tac gtg     1176
 Ser Ala Val His Cys Lys Pro Met Val Val Asp Ser Gln Leu Tyr Val
 255                 260                 265                 270

 gtc gtg gcc cag ctg ttt ggc ggc tct tac att tac cac tgg gat ccc     1224
 Val Val Ala Gln Leu Phe Gly Gly Ser Tyr Ile Tyr His Trp Asp Pro
                 275                 280                 285

 aac acc acg cgc ttc acc agg ctg caa gac att gac ccg cag cgc gtg     1272
 Asn Thr Thr Arg Phe Thr Arg Leu Gln Asp Ile Asp Pro Gln Arg Val
             290                 295                 300

 cgc aag cct aac gac cta gaa gcc ttc cgc atc gac ggt gac tgg tac     1320
 Arg Lys Pro Asn Asp Leu Glu Ala Phe Arg Ile Asp Gly Asp Trp Tyr
         305                 310                 315

 ttt gcc gtg gct gac agc tcc aag gca ggc gcc acc agc ctc tac cgc     1368
 Phe Ala Val Ala Asp Ser Ser Lys Ala Gly Ala Thr Ser Leu Tyr Arg
     320                 325                 330

 tgg cac cag aat ggc ttc tac tcc cac cag gca ctg cac ccc tgg cac     1416
 Trp His Gln Asn Gly Phe Tyr Ser His Gln Ala Leu His Pro Trp His
 335                 340                 345                 350

 cgt gac acc gac ctg gag ttt gtg gac ggc gag ggc aag cca cgg ctg     1464
 Arg Asp Thr Asp Leu Glu Phe Val Asp Gly Glu Gly Lys Pro Arg Leu
                 355                 360                 365

 att gtg tcc agc agc tcc cag gca ccc gtc atc tat cag tgg agt cgc     1512
 Ile Val Ser Ser Ser Ser Gln Ala Pro Val Ile Tyr Gln Trp Ser Arg
             370                 375                 380

 acc cag aag cag ttt gtg gcc cag ggt gag gtg acc cag gtg cct gat     1560
 Thr Gln Lys Gln Phe Val Ala Gln Gly Glu Val Thr Gln Val Pro Asp
         385                 390                 395

 gcc caa gct gtg aaa cac ttt cgt gcc ggc cgc gac agc tac ctg tgc     1608
 Ala Gln Ala Val Lys His Phe Arg Ala Gly Arg Asp Ser Tyr Leu Cys
     400                 405                 410

 ctc agc cgc tac att ggc gac tcc aag atc ctg cgc tgg gag ggt acc     1656
 Leu Ser Arg Tyr Ile Gly Asp Ser Lys Ile Leu Arg Trp Glu Gly Thr
 415                 420                 425                 430

 cgc ttc tcg gag gtg cag gcc ctg ccc tcc cgg ggc tcg ctg gcc ctg     1704
 Arg Phe Ser Glu Val Gln Ala Leu Pro Ser Arg Gly Ser Leu Ala Leu
                 435                 440                 445

 cag ccc ttc ctt gtg ggt ggc cgc cgc tac ctg gca ctg ggc agt gat     1752
 Gln Pro Phe Leu Val Gly Gly Arg Arg Tyr Leu Ala Leu Gly Ser Asp
             450                 455                 460

 ttc tcc ttc acc cag atc tac cag tgg gat gag gga cga cag aag ttt     1800
 Phe Ser Phe Thr Gln Ile Tyr Gln Trp Asp Glu Gly Arg Gln Lys Phe
         465                 470                 475

 gta cgg ttc cag gag ctg gct gtg cag gct cct cgg gcc ttc tgc tac     1848
 Val Arg Phe Gln Glu Leu Ala Val Gln Ala Pro Arg Ala Phe Cys Tyr
     480                 485                 490

 atg cct gct ggg gac gcc cag cta ctc ctg gcc ccc agc ttc aag gga     1896
 Met Pro Ala Gly Asp Ala Gln Leu Leu Leu Ala Pro Ser Phe Lys Gly
 495                 500                 505                 510

 cag acg ctg gtg tat aga cac att gtg gtg gat ctc agt gcc tag ggg     1944
 Gln Thr Leu Val Tyr Arg His Ile Val Val Asp Leu Ser Ala 
                 515                 520

 gtgccgaggc ctctggtctc ctcagggtgg ccactggagg atgggtgggg gcctctgtga   2004

 gcaccacgta tgcctgtgtg aagacaagcg accaacctgc attcatgccc ttgtatccgc   2064

 acacgcccag tgtgtacagg cgcaccccgt ggactggccc aggaggacgt gcatcatcac   2124

 tgcaatcagc atgaacacca ggcacccctg ggacacctaa cgcccagttc ccgtgacccc   2184

 aactgcaggc cccccctact ctgcagcctt tcccatgctc tgtcccctgt ctcatgcacg   2244

 agtggtgtgg ggtgctggga gcgagggggg ccgcatcctc ctgtccttgt gcttctcctt   2304

 ctgcccctct ggtctttcct gttggtgctc caggcattgt ttacctgctc ttgctccccg   2364

 ctgtagccca cagccatatc tgtcatgctt ccccggggcc actcacccct gccccacccc   2424

 gtctgcatgc tcacatggac gcggacggac acactcatta cacactcaca cgccccgact   2484

 gcacccggtg tccatctata aacatgtcag ggcacgtgtg catacaagca gattcagcac   2544

 tgcctaccag gctctcctgt taccttgcct ctctgcttgg agggggcccc ctctgctcac   2604

 ccccagcgtg ccccccccgg aactgataag gatgagaatg gtggtgccag cttctgaggg   2664

 cctgcttggc ctcctggggg caaagcccct ctgcccgaag caataacaac agcagcagaa   2724

 gcaatcccgg ggagctgcca ggggtgtctg tctctgttct ccttggcgtt tccttcatgg   2784

 ccgtgaatcc cagctcaccc atggacagaa gacctcccct catctgaaag cctttctgcc   2844

 ttccttcctg tagctgtcgc tttctcaggc ttggactgtc ccctggttca ccctgtcttt   2904

 gggatgtggc ccttgagctg ggcgggctcc ttgggtggat tagagagctg gccgagctgc   2964

 aagcacctga gttacctgcg agggtgccca gagtggagct tggcctgagg gcgtgttgca   3024

 gccctggccc caccagtcca cagaggcccc caggagcact gcctttcagt ggaccgggtg   3084

 ggggctggtg ggaggggccc cactagctga gcttctgctg ccctctgctg tctgctgaga   3144

 tgccaggcta gtggagaggg cacaccatgt gcccaaatgg tgtgatgctc cttgtagcag   3204

 gataccaggg tactgggggg caatgctatg attaacttgc ttcaaataaa aagttcccgc   3264

 cccataaaaa aaaaaaaaaa aaaaaaaaca ctt                                3297




      <210> 415
      <211> 2349
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2349)

      <400> 415
  atg aca tgt ctc cgc acc ggc acc gag ggg gcg cag ggc ggc gtg ggg      48
  Met Thr Cys Leu Arg Thr Gly Thr Glu Gly Ala Gln Gly Gly Val Gly
    1               5                  10                  15

 agg ggg acc cag gcc ggg ggt ccg ggt ggc gcg ccc tct ctc acc ccc       96
 Arg Gly Thr Gln Ala Gly Gly Pro Gly Gly Ala Pro Ser Leu Thr Pro
              20                  25                  30

 gag gcg gca gga gca gcg cgg cgc gag gac acc tcc ggg ccg tcg gtg      144
 Glu Ala Ala Gly Ala Ala Arg Arg Glu Asp Thr Ser Gly Pro Ser Val
          35                  40                  45

 ccc ctg agc ttc ccg gcg gcg cgc tgc ccc agg aaa gtt ccc ggc ctg      192
 Pro Leu Ser Phe Pro Ala Ala Arg Cys Pro Arg Lys Val Pro Gly Leu
      50                  55                  60

 ccg ccc ctc ggg ctg ttg gaa agt ttc ggc ggc tgc agg gcc ctg gca      240
 Pro Pro Leu Gly Leu Leu Glu Ser Phe Gly Gly Cys Arg Ala Leu Ala
  65                  70                  75                  80

 gct agg cgc caa gcg tcg cgc ggg gcg ggc acg gct gcg ggg tcg ggc      288
 Ala Arg Arg Gln Ala Ser Arg Gly Ala Gly Thr Ala Ala Gly Ser Gly
                  85                  90                  95

 cgc gct cgg ctg gag tgc tca gtg caa gac gcc cgg acg ggc cca gcg      336
 Arg Ala Arg Leu Glu Cys Ser Val Gln Asp Ala Arg Thr Gly Pro Ala
             100                 105                 110

 cgc aac ccg aga ccc cgg gcc agc cct ccc gcc ctc acg cgg ccc gtg      384
 Arg Asn Pro Arg Pro Arg Ala Ser Pro Pro Ala Leu Thr Arg Pro Val
         115                 120                 125

 cgc aaa gcg gac cgg gcc ggc gac gcg aat ctc cgc ccc gcc cca tct      432
 Arg Lys Ala Asp Arg Ala Gly Asp Ala Asn Leu Arg Pro Ala Pro Ser
     130                 135                 140

 gac agc aaa ttt tcc cat tgg tcg aga gac ccg gcg cgg cac ggc aac      480
 Asp Ser Lys Phe Ser His Trp Ser Arg Asp Pro Ala Arg His Gly Asn
 145                 150                 155                 160

 cgg cgc cga ttg ggc gga tgc gcg gag atg acg gct tgc cat tgg gcc      528
 Arg Arg Arg Leu Gly Gly Cys Ala Glu Met Thr Ala Cys His Trp Ala
                 165                 170                 175

 tcc ggg atg tca gtc ccg gcg gat gac cgg ccc cct cgc gga ggg gcc      576
 Ser Gly Met Ser Val Pro Ala Asp Asp Arg Pro Pro Arg Gly Gly Ala
             180                 185                 190

 gcg gcc ccg cac ctg ccc gaa cct ctg cgg cgg cgg tgg cag ggt acg      624
 Ala Ala Pro His Leu Pro Glu Pro Leu Arg Arg Arg Trp Gln Gly Thr
         195                 200                 205

 cgg gac cgc tcc ctc cca gcc gac tta cga gaa cat ccc ccg acc atc      672
 Arg Asp Arg Ser Leu Pro Ala Asp Leu Arg Glu His Pro Pro Thr Ile
     210                 215                 220

 cag ccc cga gca ggg act ggc aga gcc ggc gcc cct tcc ccg gac tct      720
 Gln Pro Arg Ala Gly Thr Gly Arg Ala Gly Ala Pro Ser Pro Asp Ser
 225                 230                 235                 240

 ggc cgc gta gcc tcc gcc acc act ccc agt tca cag gta tcc ttc ttc      768
 Gly Arg Val Ala Ser Ala Thr Thr Pro Ser Ser Gln Val Ser Phe Phe
                 245                 250                 255

 agc gcc tgc tac tcg ctg cgc gct gcg cgc cgc tcc ctc ctg tcg aca      816
 Ser Ala Cys Tyr Ser Leu Arg Ala Ala Arg Arg Ser Leu Leu Ser Thr
             260                 265                 270

 tcg aat tgt att ctt cac gca agc cgc gag aga gag ttc tgc tgc tat      864
 Ser Asn Cys Ile Leu His Ala Ser Arg Glu Arg Glu Phe Cys Cys Tyr
         275                 280                 285

 ccc cat ttt aca gtt ggg aaa cag cct cag aga ggt tct cac ttg ctt      912
 Pro His Phe Thr Val Gly Lys Gln Pro Gln Arg Gly Ser His Leu Leu
     290                 295                 300

 gaa cac agt cgt ctg acc ctg ggg cct ggg ggc tct ctc atc ctc acg      960
 Glu His Ser Arg Leu Thr Leu Gly Pro Gly Gly Ser Leu Ile Leu Thr
 305                 310                 315                 320

 ccc ctg ggt ccc cgc agc ggg gag acg atg gag gga gcc gcg gag tcc     1008
 Pro Leu Gly Pro Arg Ser Gly Glu Thr Met Glu Gly Ala Ala Glu Ser
                 325                 330                 335

 ccg aag gcc gct gga tca gga agc gct cag acg ccc gcg cag ccc gaa     1056
 Pro Lys Ala Ala Gly Ser Gly Ser Ala Gln Thr Pro Ala Gln Pro Glu
             340                 345                 350

 gct ttg gcg cag ccc cgg ggg cgg ggc gcc agg agg tgg cag cct ccg     1104
 Ala Leu Ala Gln Pro Arg Gly Arg Gly Ala Arg Arg Trp Gln Pro Pro
         355                 360                 365

 agc gac agc gcg ccc agc caa cgg gac gcc ggc atg cgg cgc gcc gcc     1152
 Ser Asp Ser Ala Pro Ser Gln Arg Asp Ala Gly Met Arg Arg Ala Ala
     370                 375                 380

 ccg ccc ctc gct gcg cgg ccc aat ggt gaa cgc gcc ggc ttc ggg ctg     1200
 Pro Pro Leu Ala Ala Arg Pro Asn Gly Glu Arg Ala Gly Phe Gly Leu
 385                 390                 395                 400

 ggc ggt act ggg ctg gct gcg gtg gcg cgc ggg cgc ggc acc cgg aag     1248
 Gly Gly Thr Gly Leu Ala Ala Val Ala Arg Gly Arg Gly Thr Arg Lys
                 405                 410                 415

 tcg gcg gcg gtg gcg gag gcg acc tcg cga cct gtg tca gca gag ccg     1296
 Ser Ala Ala Val Ala Glu Ala Thr Ser Arg Pro Val Ser Ala Glu Pro
             420                 425                 430

 ccc tgc acc acc atg tgc atc atc ttc ttt aag ttt gat cct cgc cct     1344
 Pro Cys Thr Thr Met Cys Ile Ile Phe Phe Lys Phe Asp Pro Arg Pro
         435                 440                 445

 gtt tcc aaa aac gcg tac agg gtc ctg ggt gcc cag cca gtt ctc atg     1392
 Val Ser Lys Asn Ala Tyr Arg Val Leu Gly Ala Gln Pro Val Leu Met
     450                 455                 460

 cca ccc aag ctg ctg tgt gca gga agg ctc atc ttg gca gcc aac agg     1440
 Pro Pro Lys Leu Leu Cys Ala Gly Arg Leu Ile Leu Ala Ala Asn Arg
 465                 470                 475                 480

 gat gaa ttc tac agc cga ccc tcc aag tta gct gac ttc tgg ggg aac     1488
 Asp Glu Phe Tyr Ser Arg Pro Ser Lys Leu Ala Asp Phe Trp Gly Asn
                 485                 490                 495

 aac aac gag atc ctc agt ggg ctg gac atg gag gaa ggc aag gaa gga     1536
 Asn Asn Glu Ile Leu Ser Gly Leu Asp Met Glu Glu Gly Lys Glu Gly
             500                 505                 510

 ggc aca tgg ctg ggc atc agc aca cgt ggc aag ctg gca gca ctc acc     1584
 Gly Thr Trp Leu Gly Ile Ser Thr Arg Gly Lys Leu Ala Ala Leu Thr
         515                 520                 525

 aac tac ctg cag ccg cag ctg gac tgg cag gca cga ggg cga ggt gaa     1632
 Asn Tyr Leu Gln Pro Gln Leu Asp Trp Gln Ala Arg Gly Arg Gly Glu
     530                 535                 540

 ctt gtc acc cac ttt ctg acc act gac gtg gac agc ttg tcc tac ctg     1680
 Leu Val Thr His Phe Leu Thr Thr Asp Val Asp Ser Leu Ser Tyr Leu
 545                 550                 555                 560

 aag aag gtc tct atg gag ggc cat ctg tac aat ggc ttc aac ctc ata     1728
 Lys Lys Val Ser Met Glu Gly His Leu Tyr Asn Gly Phe Asn Leu Ile
                 565                 570                 575

 gca gcc gac ctg agc aca gca aag gga gac gtc att tgc tac tat ggg     1776
 Ala Ala Asp Leu Ser Thr Ala Lys Gly Asp Val Ile Cys Tyr Tyr Gly
             580                 585                 590

 aac cga ggg gag cct gat cct atc gtt ttg acg cca ggc acc tac ggg     1824
 Asn Arg Gly Glu Pro Asp Pro Ile Val Leu Thr Pro Gly Thr Tyr Gly
         595                 600                 605

 ctg agc aac gcg ctg ctg gag act ccc tgg agg aag ctg tgc ttt ggg     1872
 Leu Ser Asn Ala Leu Leu Glu Thr Pro Trp Arg Lys Leu Cys Phe Gly
     610                 615                 620

 aag cag ctc ttc ctg gag gct gtg gaa cgg agc cag gcg ctg ccc aag     1920
 Lys Gln Leu Phe Leu Glu Ala Val Glu Arg Ser Gln Ala Leu Pro Lys
 625                 630                 635                 640

 gat gtg ctc atc gcc agc ctc ctg gat gtg ctc aac aat gaa gag gcg     1968
 Asp Val Leu Ile Ala Ser Leu Leu Asp Val Leu Asn Asn Glu Glu Ala
                 645                 650                 655

 cag ctg cca gac ccg gcc atc gag gac cag ggt ggg gag tac gtg cag     2016
 Gln Leu Pro Asp Pro Ala Ile Glu Asp Gln Gly Gly Glu Tyr Val Gln
             660                 665                 670

 ccc atg ctg agc aag tac gcg gct gtg tgc gtg cgc tgc cct ggc tac     2064
 Pro Met Leu Ser Lys Tyr Ala Ala Val Cys Val Arg Cys Pro Gly Tyr
         675                 680                 685

 ggc acc agg tat tgc agc acc gtg ggt gcg cca cct cct atc cca tgt     2112
 Gly Thr Arg Tyr Cys Ser Thr Val Gly Ala Pro Pro Pro Ile Pro Cys
     690                 695                 700

 ccc acc tcc cac gct aga ggg ccg gca aag aag cca agt gcc cat agc     2160
 Pro Thr Ser His Ala Arg Gly Pro Ala Lys Lys Pro Ser Ala His Ser
 705                 710                 715                 720

 cag agc cag gct tct tcc tcg cct gag tgg att cca gag ctt ctg ccc     2208
 Gln Ser Gln Ala Ser Ser Ser Pro Glu Trp Ile Pro Glu Leu Leu Pro
                 725                 730                 735

 tgt cca gac gca gct gca gga acc aac act atc atc ctg gta gat gcg     2256
 Cys Pro Asp Ala Ala Ala Gly Thr Asn Thr Ile Ile Leu Val Asp Ala
             740                 745                 750

 gac ggc cac gtg acc ttc act gag cgt agc atg atg gac aag gac ctc     2304
 Asp Gly His Val Thr Phe Thr Glu Arg Ser Met Met Asp Lys Asp Leu
         755                 760                 765

 tcc cac tgg gag acc aga acc tat gag ttc aca ctg cag agc taa         2349
 Ser His Trp Glu Thr Arg Thr Tyr Glu Phe Thr Leu Gln Ser 
     770                 775                 780





      <210> 416
      <211> 1561
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (271)..(1561)

      <400> 416
 tttgcagaat gaatattcca gtacagatac accgtatccc ggtagcctgc ctccagaact     60

 ccgggtgaag tcagatgagc ctccagggcc ctctgagcaa gttggacctt ctcaattcca    120

 tctagagccc gaaactcaaa atccagagac ccttgaagac atccagtcct cttcactcca    180

 acaagaagcc ccagcacagc ttccacagct ccttgaggaa gaaccttctt caatgcagca    240

 ggaggcccag ctttgcctcc agagtcctct     atg ggg agt cta act cta ccg     291
                                      Met Gly Ser Leu Thr Leu Pro
                                        1               5

 gat cat gag gtg tca gtt caa cct cca ggt gag gat caa gct tat tat      339
 Asp His Glu Val Ser Val Gln Pro Pro Gly Glu Asp Gln Ala Tyr Tyr
          10                  15                  20

 caa ttg gcc aac att aca gtt aaa cct gca gat gtg gaa gtt acc ata      387
 Gln Leu Ala Asn Ile Thr Val Lys Pro Ala Asp Val Glu Val Thr Ile
      25                  30                  35

 act tca gag ccc aaa aat gag aca gaa tct tcc caa gcc cag cag gag      435
 Thr Ser Glu Pro Lys Asn Glu Thr Glu Ser Ser Gln Ala Gln Gln Glu
  40                  45                  50                  55

 gcc cca att cag cct cca gag gag gtg gca cct tct gca acc caa cag      483
 Ala Pro Ile Gln Pro Pro Glu Glu Val Ala Pro Ser Ala Thr Gln Gln
                  60                  65                  70

 gag gcc cca act gag cct cca ggt cct cct atg gag cct gaa ctt tcc      531
 Glu Ala Pro Thr Glu Pro Pro Gly Pro Pro Met Glu Pro Glu Leu Ser
              75                  80                  85

 ccc agt gaa cag gag cag cca gct cag cct tct gag tct tct gga gag      579
 Pro Ser Glu Gln Glu Gln Pro Ala Gln Pro Ser Glu Ser Ser Gly Glu
          90                  95                 100

 gtt gaa tct tct cca gcc cag cac gag acc cca gct cag cct cca gaa      627
 Val Glu Ser Ser Pro Ala Gln His Glu Thr Pro Ala Gln Pro Pro Glu
     105                 110                 115

 gag atg gaa cca tct gca ttc caa gag gag gcc cca act gag cct cca      675
 Glu Met Glu Pro Ser Ala Phe Gln Glu Glu Ala Pro Thr Glu Pro Pro
 120                 125                 130                 135

 cgt cct cct ata gag cct gaa ctt tcc ccc aag tca tca gaa gag gct      723
 Arg Pro Pro Ile Glu Pro Glu Leu Ser Pro Lys Ser Ser Glu Glu Ala
                 140                 145                 150

 gga cat tta caa att caa cag gaa act tca gtt caa tct cca gaa cct      771
 Gly His Leu Gln Ile Gln Gln Glu Thr Ser Val Gln Ser Pro Glu Pro
             155                 160                 165

 att aat aaa gag aac acc act cca acc cag cag gag gct gca gct gag      819
 Ile Asn Lys Glu Asn Thr Thr Pro Thr Gln Gln Glu Ala Ala Ala Glu
         170                 175                 180

 cat cca cag acc gct gag gag gac aag ggt cag gct cag ctt tca cac      867
 His Pro Gln Thr Ala Glu Glu Asp Lys Gly Gln Ala Gln Leu Ser His
     185                 190                 195

 ctg acc gaa gcc aca gtt caa cct ctg gac ctg gag ctt agc ata act      915
 Leu Thr Glu Ala Thr Val Gln Pro Leu Asp Leu Glu Leu Ser Ile Thr
 200                 205                 210                 215

 aca gag cct act aca gag gtt aaa cca tct cca acc acg gag gaa acc      963
 Thr Glu Pro Thr Thr Glu Val Lys Pro Ser Pro Thr Thr Glu Glu Thr
                 220                 225                 230

 tca gct cag cct cta gac ccg ggg ctt gcc ata act cca gaa cct act     1011
 Ser Ala Gln Pro Leu Asp Pro Gly Leu Ala Ile Thr Pro Glu Pro Thr
             235                 240                 245

 aca gag att gga cat tcc aca gcc ctg gag aag act aga gct cct cat     1059
 Thr Glu Ile Gly His Ser Thr Ala Leu Glu Lys Thr Arg Ala Pro His
         250                 255                 260

 cca gac cag gtt cag act ctg cat cga agc ctg act gaa gtc aca ggt     1107
 Pro Asp Gln Val Gln Thr Leu His Arg Ser Leu Thr Glu Val Thr Gly
     265                 270                 275

 cca cct aca aag tta gaa tct tcg cag gat tca ttg gtg cag tct gaa     1155
 Pro Pro Thr Lys Leu Glu Ser Ser Gln Asp Ser Leu Val Gln Ser Glu
 280                 285                 290                 295

 act gca cca gag gaa cag aag gcc tcc aca ggc acc aac ata tgt gag     1203
 Thr Ala Pro Glu Glu Gln Lys Ala Ser Thr Gly Thr Asn Ile Cys Glu
                 300                 305                 310

 ctc tgc acc tgc gga gat gag act ctg tca tgt gtt ggt ctc agc cca     1251
 Leu Cys Thr Cys Gly Asp Glu Thr Leu Ser Cys Val Gly Leu Ser Pro
             315                 320                 325

 aag cag agg ctc cgc caa gtg cct gtg cca gag ccc tac acc tac aat     1299
 Lys Gln Arg Leu Arg Gln Val Pro Val Pro Glu Pro Tyr Thr Tyr Asn
         330                 335                 340

 ggc atc ttc acc acc tta aat ttc caa gga aac tat att tca tac att     1347
 Gly Ile Phe Thr Thr Leu Asn Phe Gln Gly Asn Tyr Ile Ser Tyr Ile
     345                 350                 355

 gat gga aat gta tgg aaa gca tac agt tgg acc gag aaa cta att ctc     1395
 Asp Gly Asn Val Trp Lys Ala Tyr Ser Trp Thr Glu Lys Leu Ile Leu
 360                 365                 370                 375

 agt gaa aat tat ttg act gaa tta cct aag gat tca ttt gaa ggc ctg     1443
 Ser Glu Asn Tyr Leu Thr Glu Leu Pro Lys Asp Ser Phe Glu Gly Leu
                 380                 385                 390

 cta tcc ctc cag tat tta cag att ctt tca aat gtg aaa ggc tta agg     1491
 Leu Ser Leu Gln Tyr Leu Gln Ile Leu Ser Asn Val Lys Gly Leu Arg
             395                 400                 405

 aaa gtg ggt gta aag gcc ctc aag tgg atg cca aag tgc tgc cgg ggc     1539
 Lys Val Gly Val Lys Ala Leu Lys Trp Met Pro Lys Cys Cys Arg Gly
         410                 415                 420

 cat gaa gta att aaa ctt cat t                                       1561
 His Glu Val Ile Lys Leu His 
     425                 430





      <210> 417
      <211> 1597
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (317)..(1249)

      <400> 417
 ctggaccttg gctaggaatg tgggagagga tgagctaagt agagagtcca gccctgatat     60

 tgaggagatc agtttaaggt ctttgttttg ggctgagagt gagaacagta atacgttcag    120

 atctaagagt gggaaagatg ccagttttga gtctggagct ggggataaca ccagcatcaa    180

 ggataagttt gaggctgctg gtggagttga tatagggtct tggttctgtg ctggtaatga    240

 aaacacaagt gaggacaaat ctgcacctaa ggctaaagcc aaaaagtcat ctgagtcaag    300

 aggcatatat ccgtac    atg gtc cct ggg gca gga atg ggg tca tgg gat     349
                      Met Val Pro Gly Ala Gly Met Gly Ser Trp Asp
                        1               5                  10

 gga gcc atg atc tgg tcg gaa act aag ttt gca cac caa agt gag gcc      397
 Gly Ala Met Ile Trp Ser Glu Thr Lys Phe Ala His Gln Ser Glu Ala
              15                  20                  25

 agc ttc cca gtt gaa gat gag tcc aga aaa caa acc agg act ggg gaa      445
 Ser Phe Pro Val Glu Asp Glu Ser Arg Lys Gln Thr Arg Thr Gly Glu
          30                  35                  40

 aaa act cgg ccc tgg tct tgc cgc tgt aaa cac gaa gct aat atg gat      493
 Lys Thr Arg Pro Trp Ser Cys Arg Cys Lys His Glu Ala Asn Met Asp
      45                  50                  55

 cca cga gat ctt gaa aaa ctc att tgc atg att gag atg act gaa gat      541
 Pro Arg Asp Leu Glu Lys Leu Ile Cys Met Ile Glu Met Thr Glu Asp
  60                  65                  70                  75

 cct tct gtt cat gaa ata gcc aat aat gct tta tat aac agt gct gat      589
 Pro Ser Val His Glu Ile Ala Asn Asn Ala Leu Tyr Asn Ser Ala Asp
                  80                  85                  90

 tat tct tat tct cat gaa gtt gtt cgt aat gta ggt gga att tca gtt      637
 Tyr Ser Tyr Ser His Glu Val Val Arg Asn Val Gly Gly Ile Ser Val
              95                 100                 105

 att gaa agc ttg ctc aat aat ccc tac ccc agt gtt agg cag aag gct      685
 Ile Glu Ser Leu Leu Asn Asn Pro Tyr Pro Ser Val Arg Gln Lys Ala
         110                 115                 120

 tta aat gca ctg aat aat atc tca gtg gct gct gaa aac cat agg aag      733
 Leu Asn Ala Leu Asn Asn Ile Ser Val Ala Ala Glu Asn His Arg Lys
     125                 130                 135

 gtt aaa act tac tta aac caa gta tgt gaa gac act gtc acc tat ccc      781
 Val Lys Thr Tyr Leu Asn Gln Val Cys Glu Asp Thr Val Thr Tyr Pro
 140                 145                 150                 155

 ttg aat tca aat gtg cag ttg gct gga cta agg ttg ata agg cat ctg      829
 Leu Asn Ser Asn Val Gln Leu Ala Gly Leu Arg Leu Ile Arg His Leu
                 160                 165                 170

 act att acc agt gaa tat cag cat atg gtt aca aat tat att tca gaa      877
 Thr Ile Thr Ser Glu Tyr Gln His Met Val Thr Asn Tyr Ile Ser Glu
             175                 180                 185

 ttt ctt cgt ttg tta acg gtg gga agt gga gaa act aaa gac cat gtt      925
 Phe Leu Arg Leu Leu Thr Val Gly Ser Gly Glu Thr Lys Asp His Val
         190                 195                 200

 ttg gga atg ctt ttg aat ttc tct aaa aat cca tct atg aca aaa gac      973
 Leu Gly Met Leu Leu Asn Phe Ser Lys Asn Pro Ser Met Thr Lys Asp
     205                 210                 215

 ttg ctc att gcc aat gca cca aca tca ctg att aac att ttt agc aag     1021
 Leu Leu Ile Ala Asn Ala Pro Thr Ser Leu Ile Asn Ile Phe Ser Lys
 220                 225                 230                 235

 aaa gag aca aag gag aat att ctt aat gct ctt tca cta ttt gaa aat     1069
 Lys Glu Thr Lys Glu Asn Ile Leu Asn Ala Leu Ser Leu Phe Glu Asn
                 240                 245                 250

 ata aat tac cat ttt aaa aga aga gca aaa gca ttt acc cag gac aaa     1117
 Ile Asn Tyr His Phe Lys Arg Arg Ala Lys Ala Phe Thr Gln Asp Lys
             255                 260                 265

 ttc agt aaa aat tcc ctt tat ttc cta ttc caa cga cct aaa gca tgt     1165
 Phe Ser Lys Asn Ser Leu Tyr Phe Leu Phe Gln Arg Pro Lys Ala Cys
         270                 275                 280

 gcc aag aaa ctt cga gcc tta gca gca gaa tgc aat gac cct gag gtg     1213
 Ala Lys Lys Leu Arg Ala Leu Ala Ala Glu Cys Asn Asp Pro Glu Val
     285                 290                 295

 aaa gag aga gtt gag cta tta ata agt aaa ctc tga ttgg ctgtatgttc     1263
 Lys Glu Arg Val Glu Leu Leu Ile Ser Lys Leu 
 300                 305                 310

 ccaaacaaat ttgagtaata ttttggtttt gcactctgga agtaatgcac attgtaaatt   1323

 gcattataac tttgaaactg atgttaccta tgatggtcta tagctggacc attttatgaa   1383

 caccaaatga attcaagctt gtactaaaaa tacatgtgtt gatttttatc ttgtctggat   1443

 tgagatattt ttagtatgct tcatgagcag aaactgaatg gattcttcat aagtaaggta   1503

 atctttggtc ctttgtgtgg acttatgttt atacatttaa gactattttt atgtcatcaa   1563

 taaagttgtg tgttttaagc agcaaaaaaa aaaa                               1597




      <210> 418
      <211> 6315
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(5058)

      <400> 418
  atg ctg cct cca aag cac ttg tct gcc acc aaa cct aag aag tcc tgg      48
  Met Leu Pro Pro Lys His Leu Ser Ala Thr Lys Pro Lys Lys Ser Trp
    1               5                  10                  15

 gcc cca aat ctg tat gag cta gac agt gac ttg act aag gag ccg gat       96
 Ala Pro Asn Leu Tyr Glu Leu Asp Ser Asp Leu Thr Lys Glu Pro Asp
              20                  25                  30

 gtc atc ata gga gaa ggt cca act gac tct gag ttt ttt cat cag agg      144
 Val Ile Ile Gly Glu Gly Pro Thr Asp Ser Glu Phe Phe His Gln Arg
          35                  40                  45

 ttt cgg aac cta atc tat gtg gaa ttt gtt ggg cct cgg aag acc ctg      192
 Phe Arg Asn Leu Ile Tyr Val Glu Phe Val Gly Pro Arg Lys Thr Leu
      50                  55                  60

 atc aaa ctc cga aac ctc tgc ctc gat tgg ttg cag ccg gag acc cgc      240
 Ile Lys Leu Arg Asn Leu Cys Leu Asp Trp Leu Gln Pro Glu Thr Arg
  65                  70                  75                  80

 acc aag gag gag atc atc gag ctc ttg gtc ctt gag cag tac ctg acc      288
 Thr Lys Glu Glu Ile Ile Glu Leu Leu Val Leu Glu Gln Tyr Leu Thr
                  85                  90                  95

 atc atc cct gaa aag ctc aag cct tgg gtg cga gca aaa aag ccg gag      336
 Ile Ile Pro Glu Lys Leu Lys Pro Trp Val Arg Ala Lys Lys Pro Glu
             100                 105                 110

 aac tgt gag aag ctc gtc act ctg ctg gag aat tac aag gag atg tac      384
 Asn Cys Glu Lys Leu Val Thr Leu Leu Glu Asn Tyr Lys Glu Met Tyr
         115                 120                 125

 caa cca gaa ggt gag agt ctc cac ggg gtg ttg gtg gtc agt gca ggc      432
 Gln Pro Glu Gly Glu Ser Leu His Gly Val Leu Val Val Ser Ala Gly
     130                 135                 140

 ctc agg tgt ccc ctg ggg ctc tca gcc tcc aca ctt ctg aca tgg tct      480
 Leu Arg Cys Pro Leu Gly Leu Ser Ala Ser Thr Leu Leu Thr Trp Ser
 145                 150                 155                 160

 gga ctg gat aac tct ctg tcc tgg gca gcg gtg ggg atg tcc tgt gta      528
 Gly Leu Asp Asn Ser Leu Ser Trp Ala Ala Val Gly Met Ser Cys Val
                 165                 170                 175

 ctg tgg gat att gag ctg cat cat gat ttt ctg ggt gtg gcc acc aaa      576
 Leu Trp Asp Ile Glu Leu His His Asp Phe Leu Gly Val Ala Thr Lys
             180                 185                 190

 agt gtc tcc aca cat gcc cag gga gat gcg gct cag gga ttg ggg gga      624
 Ser Val Ser Thr His Ala Gln Gly Asp Ala Ala Gln Gly Leu Gly Gly
         195                 200                 205

 act att gtg aga atg tgg gcc aga gat agt aac ttg gcg acc ggt gtc      672
 Thr Ile Val Arg Met Trp Ala Arg Asp Ser Asn Leu Ala Thr Gly Val
     210                 215                 220

 ctc tta gac gac aac aac agt gac gtg acc agc gac gac gac atg acc      720
 Leu Leu Asp Asp Asn Asn Ser Asp Val Thr Ser Asp Asp Asp Met Thr
 225                 230                 235                 240

 cgg aac aga aga gag tcc tca cca cct cac tca gtc cat tct ttc agt      768
 Arg Asn Arg Arg Glu Ser Ser Pro Pro His Ser Val His Ser Phe Ser
                 245                 250                 255

 ggt gac cgg gac tgg gac cgg agg ggc aga agc aga gac atg gag cca      816
 Gly Asp Arg Asp Trp Asp Arg Arg Gly Arg Ser Arg Asp Met Glu Pro
             260                 265                 270

 cga gac cgc tgg tcc cac acc agg aac cca aga agc agg atg cct ccg      864
 Arg Asp Arg Trp Ser His Thr Arg Asn Pro Arg Ser Arg Met Pro Pro
         275                 280                 285

 cgg gat ctt tcc ctt cct gtg gtg gcg aaa aca agc ttt gaa atg gac      912
 Arg Asp Leu Ser Leu Pro Val Val Ala Lys Thr Ser Phe Glu Met Asp
     290                 295                 300

 aga gag gac gac agg gac tcc agg gct tat gag tcc cga tct cag gat      960
 Arg Glu Asp Asp Arg Asp Ser Arg Ala Tyr Glu Ser Arg Ser Gln Asp
 305                 310                 315                 320

 gct gaa tca tac caa aat gtg gtg gac ctc gct gag gac agg aaa cct     1008
 Ala Glu Ser Tyr Gln Asn Val Val Asp Leu Ala Glu Asp Arg Lys Pro
                 325                 330                 335

 cac aac aca atc cag gac aac atg gaa aac tac agg aag ctg ctc tcc     1056
 His Asn Thr Ile Gln Asp Asn Met Glu Asn Tyr Arg Lys Leu Leu Ser
             340                 345                 350

 ctc gga gtg cag ctt gct gaa gac gat ggc cac tcc cac atg acg cag     1104
 Leu Gly Val Gln Leu Ala Glu Asp Asp Gly His Ser His Met Thr Gln
         355                 360                 365

 ggc cac tca tca aga tcc aag aga agt gcc tac cca agc acc agt cga     1152
 Gly His Ser Ser Arg Ser Lys Arg Ser Ala Tyr Pro Ser Thr Ser Arg
     370                 375                 380

 ggt cta aaa act atg cct gaa gcc aaa aaa tca acc cac cgg cgg ggg     1200
 Gly Leu Lys Thr Met Pro Glu Ala Lys Lys Ser Thr His Arg Arg Gly
 385                 390                 395                 400

 att tgt gaa gat gaa tct tcc cac gga gtg ata atg gaa aaa ttc atc     1248
 Ile Cys Glu Asp Glu Ser Ser His Gly Val Ile Met Glu Lys Phe Ile
                 405                 410                 415

 aag gat gtg tca cgc agt tcc aaa tcg gga aga gca agg gag tca agc     1296
 Lys Asp Val Ser Arg Ser Ser Lys Ser Gly Arg Ala Arg Glu Ser Ser
             420                 425                 430

 gac cgg tca cag aga ttc ccc aga atg tca gat gat aac tgg aag gac     1344
 Asp Arg Ser Gln Arg Phe Pro Arg Met Ser Asp Asp Asn Trp Lys Asp
         435                 440                 445

 att tca ttg aac aag agg gag tca gtg atc cag cag cgg gtt tat gaa     1392
 Ile Ser Leu Asn Lys Arg Glu Ser Val Ile Gln Gln Arg Val Tyr Glu
     450                 455                 460

 ggg aat gca ttt agg gga ggc ttt agg ttt aat tca acc ctt gtt tcc     1440
 Gly Asn Ala Phe Arg Gly Gly Phe Arg Phe Asn Ser Thr Leu Val Ser
 465                 470                 475                 480

 aga aag aga gtt ctt gaa aga aag agg cgc tat cat ttt gac aca gat     1488
 Arg Lys Arg Val Leu Glu Arg Lys Arg Arg Tyr His Phe Asp Thr Asp
                 485                 490                 495

 ggg aag ggc tcg att cac gat caa aaa ggc tgt ccc agg aag aag ccc     1536
 Gly Lys Gly Ser Ile His Asp Gln Lys Gly Cys Pro Arg Lys Lys Pro
             500                 505                 510

 ttt gaa tgt ggt agt gag atg aga aaa gcc atg agc gtg agc agc ctg     1584
 Phe Glu Cys Gly Ser Glu Met Arg Lys Ala Met Ser Val Ser Ser Leu
         515                 520                 525

 agc agc ctc agc tcc ccc tcc ttt acc gag tca cag cca att gat ttt     1632
 Ser Ser Leu Ser Ser Pro Ser Phe Thr Glu Ser Gln Pro Ile Asp Phe
     530                 535                 540

 ggg gca atg cca tat gta tgt gat gag tgt ggg agg tcg ttc agt gtc     1680
 Gly Ala Met Pro Tyr Val Cys Asp Glu Cys Gly Arg Ser Phe Ser Val
 545                 550                 555                 560

 atc tca gaa ttt gtt gag cac cag atc atg cat act aga gag aac ctc     1728
 Ile Ser Glu Phe Val Glu His Gln Ile Met His Thr Arg Glu Asn Leu
                 565                 570                 575

 tat gag tat ggt gag tcc ttt atc cac agt gtg gct gtc agt gaa gtt     1776
 Tyr Glu Tyr Gly Glu Ser Phe Ile His Ser Val Ala Val Ser Glu Val
             580                 585                 590

 cag aaa agt cag gtt gga ggg aaa cgt ttt gaa tgt aag gac tgt gga     1824
 Gln Lys Ser Gln Val Gly Gly Lys Arg Phe Glu Cys Lys Asp Cys Gly
         595                 600                 605

 gag acc ttc aat aag agt gcc gcc ttg gct gaa cat cgg aag att cat     1872
 Glu Thr Phe Asn Lys Ser Ala Ala Leu Ala Glu His Arg Lys Ile His
     610                 615                 620

 gct aga ggt tat ctt gtg gaa tgt aag aat cag gaa tgt gag gaa gcc     1920
 Ala Arg Gly Tyr Leu Val Glu Cys Lys Asn Gln Glu Cys Glu Glu Ala
 625                 630                 635                 640

 ttc atg cct agc ccc acc ttt agt gag ctt cag aaa ata tat ggc aaa     1968
 Phe Met Pro Ser Pro Thr Phe Ser Glu Leu Gln Lys Ile Tyr Gly Lys
                 645                 650                 655

 gac aaa ttc tac gag tgc agg gtg tgt aag gaa acc ttc ctt cat agt     2016
 Asp Lys Phe Tyr Glu Cys Arg Val Cys Lys Glu Thr Phe Leu His Ser
             660                 665                 670

 tct gcc ctg att gag cac cag aaa atc cac ttt ggg gat gac aaa gat     2064
 Ser Ala Leu Ile Glu His Gln Lys Ile His Phe Gly Asp Asp Lys Asp
         675                 680                 685

 aat gag cgt gaa cat gaa cgt gaa cgt gaa cgt gag cgc ggg gaa acc     2112
 Asn Glu Arg Glu His Glu Arg Glu Arg Glu Arg Glu Arg Gly Glu Thr
     690                 695                 700

 ttt agg ccc agc cca gcc ctt aat gag ttt cag aaa atg tat ggt aaa     2160
 Phe Arg Pro Ser Pro Ala Leu Asn Glu Phe Gln Lys Met Tyr Gly Lys
 705                 710                 715                 720

 gag aaa atg tac gaa tgt aag gtg tgt ggg gag act ttc ctt cat agc     2208
 Glu Lys Met Tyr Glu Cys Lys Val Cys Gly Glu Thr Phe Leu His Ser
                 725                 730                 735

 tca tcc ctg aaa gaa cat cag aaa atc cat act aga ggg aac cca ttt     2256
 Ser Ser Leu Lys Glu His Gln Lys Ile His Thr Arg Gly Asn Pro Phe
             740                 745                 750

 gaa aac aag ggt aaa gtg tgt gag gaa acc ttt att cct ggt cag tcc     2304
 Glu Asn Lys Gly Lys Val Cys Glu Glu Thr Phe Ile Pro Gly Gln Ser
         755                 760                 765

 ctt aaa agg cgt cag aaa act tac aat aag gag aag ctc tgt gac ttt     2352
 Leu Lys Arg Arg Gln Lys Thr Tyr Asn Lys Glu Lys Leu Cys Asp Phe
     770                 775                 780

 aca gat ggc cgg gat gcc ttc atg caa agc tca gag ctc agt gag cat     2400
 Thr Asp Gly Arg Asp Ala Phe Met Gln Ser Ser Glu Leu Ser Glu His
 785                 790                 795                 800

 cag aaa att cat tct cga aag aac ctc ttt gaa ggc aga ggg tat gag     2448
 Gln Lys Ile His Ser Arg Lys Asn Leu Phe Glu Gly Arg Gly Tyr Glu
                 805                 810                 815

 aaa tct gtc att cat agt ggg cca ttc act gaa tct cag aag agt cat     2496
 Lys Ser Val Ile His Ser Gly Pro Phe Thr Glu Ser Gln Lys Ser His
             820                 825                 830

 act ata aca aga cct ctt gaa agt gat gag gac gaa aag gcg ttc ccc     2544
 Thr Ile Thr Arg Pro Leu Glu Ser Asp Glu Asp Glu Lys Ala Phe Pro
         835                 840                 845

 att agc tct aac ccc tat gaa aac cag aag att ccc act aag gaa aat     2592
 Ile Ser Ser Asn Pro Tyr Glu Asn Gln Lys Ile Pro Thr Lys Glu Asn
     850                 855                 860

 gtc tat gag gca aaa tca tat gag agg tct gtt att cat agc tta gcc     2640
 Val Tyr Glu Ala Lys Ser Tyr Glu Arg Ser Val Ile His Ser Leu Ala
 865                 870                 875                 880

 tct gtg gaa gct cag aaa agt cac agt gta gca ggg ccc agt aaa cca     2688
 Ser Val Glu Ala Gln Lys Ser His Ser Val Ala Gly Pro Ser Lys Pro
                 885                 890                 895

 aaa gta atg gca gag tct acc att cag agc ttc gat gct atc aac cat     2736
 Lys Val Met Ala Glu Ser Thr Ile Gln Ser Phe Asp Ala Ile Asn His
             900                 905                 910

 cag aga gtt cgt gct gga ggg aac acc tct gaa gga agg gaa tac agt     2784
 Gln Arg Val Arg Ala Gly Gly Asn Thr Ser Glu Gly Arg Glu Tyr Ser
         915                 920                 925

 agg tct gtt atc cat agc tta gtg gct tcc aaa cct cca aga agt cac     2832
 Arg Ser Val Ile His Ser Leu Val Ala Ser Lys Pro Pro Arg Ser His
     930                 935                 940

 aat gga aat gaa ttg gtg gaa tct aat gag aag gga gaa tcc tcc att     2880
 Asn Gly Asn Glu Leu Val Glu Ser Asn Glu Lys Gly Glu Ser Ser Ile
 945                 950                 955                 960

 tat atc tca gac ctt aat gat aag cga cag aag att cct gcc aga gag     2928
 Tyr Ile Ser Asp Leu Asn Asp Lys Arg Gln Lys Ile Pro Ala Arg Glu
                 965                 970                 975

 aac cct tgt gaa ggg ggc agt aag aat cgc aac tat gaa gac tct gtc     2976
 Asn Pro Cys Glu Gly Gly Ser Lys Asn Arg Asn Tyr Glu Asp Ser Val
             980                 985                 990

 ata cag agt gta ttc cgt gcc aaa cct cag aaa agt gtt cct gga gag     3024
 Ile Gln Ser Val Phe Arg Ala Lys Pro Gln Lys Ser Val Pro Gly Glu
         995                1000                1005

 gga tct ggt gag ttt aag aag gat ggc gaa ttc tct gtt ccc agc tca     3072
 Gly Ser Gly Glu Phe Lys Lys Asp Gly Glu Phe Ser Val Pro Ser Ser
    1010                1015                1020

 aat gtc cgt gaa tac cag aag gct cgt gct aaa aag aaa tac att gag     3120
 Asn Val Arg Glu Tyr Gln Lys Ala Arg Ala Lys Lys Lys Tyr Ile Glu
1025                1030                1035                1040

 cat agg agc aat gag acc tct gta att cac tct ctg cct ttt ggt gaa     3168
 His Arg Ser Asn Glu Thr Ser Val Ile His Ser Leu Pro Phe Gly Glu
                1045                1050                1055

 caa aca ttt cgc cct cga ggg atg ctc tat gaa tgt cag gag tgt ggg     3216
 Gln Thr Phe Arg Pro Arg Gly Met Leu Tyr Glu Cys Gln Glu Cys Gly
            1060                1065                1070

 gag tgc ttt gct cat agc tct gac ctc act gag cac cag aag att cat     3264
 Glu Cys Phe Ala His Ser Ser Asp Leu Thr Glu His Gln Lys Ile His
        1075                1080                1085

 gat agg gag aag ccc tct gga agc aga aac tat gaa tgg tct gtc att     3312
 Asp Arg Glu Lys Pro Ser Gly Ser Arg Asn Tyr Glu Trp Ser Val Ile
    1090                1095                1100

 cgc agc ttg gcc cct act gac cct caa aca agt tac gcc caa gag cag     3360
 Arg Ser Leu Ala Pro Thr Asp Pro Gln Thr Ser Tyr Ala Gln Glu Gln
1105                1110                1115                1120

 tat gct aaa gag caa gcg cgg aac aaa tgt aag gac ttc aga caa ttt     3408
 Tyr Ala Lys Glu Gln Ala Arg Asn Lys Cys Lys Asp Phe Arg Gln Phe
                1125                1130                1135

 ttt gct acc agc gaa gac ctc aac aca aac cag aaa atc tat gac caa     3456
 Phe Ala Thr Ser Glu Asp Leu Asn Thr Asn Gln Lys Ile Tyr Asp Gln
            1140                1145                1150

 gag aag tct cat ggc gag gag tct caa ggc gag aat act gat ggg gag     3504
 Glu Lys Ser His Gly Glu Glu Ser Gln Gly Glu Asn Thr Asp Gly Glu
        1155                1160                1165

 gag acc cac agc gag gag acc cat ggt cag gag aca att gaa gac cct     3552
 Glu Thr His Ser Glu Glu Thr His Gly Gln Glu Thr Ile Glu Asp Pro
    1170                1175                1180

 gtc att caa ggc tca gac atg gaa gac cct cag aag gat gac cct gat     3600
 Val Ile Gln Gly Ser Asp Met Glu Asp Pro Gln Lys Asp Asp Pro Asp
1185                1190                1195                1200

 gac aaa atc tat gaa tgt gag gac tgt ggc ctg ggc ttt gtg gat ctc     3648
 Asp Lys Ile Tyr Glu Cys Glu Asp Cys Gly Leu Gly Phe Val Asp Leu
                1205                1210                1215

 aca gac ctc aca gac cat cag aaa gtc cac agc agg aag tgc ctg gtt     3696
 Thr Asp Leu Thr Asp His Gln Lys Val His Ser Arg Lys Cys Leu Val
            1220                1225                1230

 gac agt cgg gag tac aca cat tct gta att cac acc cat tcc atc agc     3744
 Asp Ser Arg Glu Tyr Thr His Ser Val Ile His Thr His Ser Ile Ser
        1235                1240                1245

 gag tat cag aga gat tac act gga gag cag ctg tat gaa tgt cca aag     3792
 Glu Tyr Gln Arg Asp Tyr Thr Gly Glu Gln Leu Tyr Glu Cys Pro Lys
    1250                1255                1260

 tgt ggg gaa tct ttt att cat agc tca ttc ctt ttc gag cat cag aga     3840
 Cys Gly Glu Ser Phe Ile His Ser Ser Phe Leu Phe Glu His Gln Arg
1265                1270                1275                1280

 atc cat gaa caa gac cag ttg tat tcc atg aag ggg tgt gat gat ggt     3888
 Ile His Glu Gln Asp Gln Leu Tyr Ser Met Lys Gly Cys Asp Asp Gly
                1285                1290                1295

 ttt att gcc ctc ttg ccc atg aag cca cgg agg aat cgt gct gca gag     3936
 Phe Ile Ala Leu Leu Pro Met Lys Pro Arg Arg Asn Arg Ala Ala Glu
            1300                1305                1310

 agg aat cct gct ctt gct ggg tcg gcc att cga tgc ctt ttg tgt gga     3984
 Arg Asn Pro Ala Leu Ala Gly Ser Ala Ile Arg Cys Leu Leu Cys Gly
        1315                1320                1325

 caa ggc ttc att cat agc tct gcc ctt aat gag cat atg aga ctt cat     4032
 Gln Gly Phe Ile His Ser Ser Ala Leu Asn Glu His Met Arg Leu His
    1330                1335                1340

 agg gaa gat gat tta ctg gag cag agc cag atg gct gag gaa gct atc     4080
 Arg Glu Asp Asp Leu Leu Glu Gln Ser Gln Met Ala Glu Glu Ala Ile
1345                1350                1355                1360

 att cca ggc tta gcc ctc act gag ttt cag aga agt cag acc gaa gag     4128
 Ile Pro Gly Leu Ala Leu Thr Glu Phe Gln Arg Ser Gln Thr Glu Glu
                1365                1370                1375

 aga ctc ttt gaa tgt gca gtc tgt gga gaa tct ttc gtc aac cca gca     4176
 Arg Leu Phe Glu Cys Ala Val Cys Gly Glu Ser Phe Val Asn Pro Ala
            1380                1385                1390

 gaa ctt gca gat cac gta act gtt cat aag aat gag ccc tat gag tac     4224
 Glu Leu Ala Asp His Val Thr Val His Lys Asn Glu Pro Tyr Glu Tyr
        1395                1400                1405

 ggg tcc tcc tat act cac acc tca ttt ctt act gag ccc ctc aaa gga     4272
 Gly Ser Ser Tyr Thr His Thr Ser Phe Leu Thr Glu Pro Leu Lys Gly
    1410                1415                1420

 gct ata cca ttc tat gaa tgc aag gat tgt ggt aag tcc ttt att cat     4320
 Ala Ile Pro Phe Tyr Glu Cys Lys Asp Cys Gly Lys Ser Phe Ile His
1425                1430                1435                1440

 agc aca gtc ctc act aaa cat aag gag ctt cat ctg gaa gaa gaa gaa     4368
 Ser Thr Val Leu Thr Lys His Lys Glu Leu His Leu Glu Glu Glu Glu
                1445                1450                1455

 gaa gat gaa gca gca gca gct gca gga gca gca gcc cag gaa gtt gaa     4416
 Glu Asp Glu Ala Ala Ala Ala Ala Gly Ala Ala Ala Gln Glu Val Glu
            1460                1465                1470

 gcc aat gtc cat gtt cca caa gta gtt ctg agg att cag ggc tta aac     4464
 Ala Asn Val His Val Pro Gln Val Val Leu Arg Ile Gln Gly Leu Asn
        1475                1480                1485

 gta gag gct gct gag cca gaa gtg gag gct gcc gag cca gaa gtg gag     4512
 Val Glu Ala Ala Glu Pro Glu Val Glu Ala Ala Glu Pro Glu Val Glu
    1490                1495                1500

 gct gct gag cca gaa gtg gag gct gct gag cca aac gga gag gct gaa     4560
 Ala Ala Glu Pro Glu Val Glu Ala Ala Glu Pro Asn Gly Glu Ala Glu
1505                1510                1515                1520

 ggg cca gat gga gag gct gca gag ccc att gga gag gct gga cag cca     4608
 Gly Pro Asp Gly Glu Ala Ala Glu Pro Ile Gly Glu Ala Gly Gln Pro
                1525                1530                1535

 aat gga gag gcc gag cag cca aat ggg gat gct gat gag cca gat ggt     4656
 Asn Gly Glu Ala Glu Gln Pro Asn Gly Asp Ala Asp Glu Pro Asp Gly
            1540                1545                1550

 gca ggt att gaa gac cca gaa gaa aga gct gaa gag cca gag gga aaa     4704
 Ala Gly Ile Glu Asp Pro Glu Glu Arg Ala Glu Glu Pro Glu Gly Lys
        1555                1560                1565

 gct gaa gag cca gag gga gat gcc gac gag cct gac ggt gtg gga att     4752
 Ala Glu Glu Pro Glu Gly Asp Ala Asp Glu Pro Asp Gly Val Gly Ile
    1570                1575                1580

 gaa gac cca gaa gaa ggt gaa gat caa gag att cag gta gaa gaa cca     4800
 Glu Asp Pro Glu Glu Gly Glu Asp Gln Glu Ile Gln Val Glu Glu Pro
1585                1590                1595                1600

 tac tat gac tgc cat gaa tgc aca gaa acc ttc act tcc agc aca gca     4848
 Tyr Tyr Asp Cys His Glu Cys Thr Glu Thr Phe Thr Ser Ser Thr Ala
                1605                1610                1615

 ttc agt gaa cac ctg aaa act cat gcc agc atg atc ata ttt gag cct     4896
 Phe Ser Glu His Leu Lys Thr His Ala Ser Met Ile Ile Phe Glu Pro
            1620                1625                1630

 gca aat gcc ttt ggg gag tgc tca ggc tac atc gaa cgt gcc agc acc     4944
 Ala Asn Ala Phe Gly Glu Cys Ser Gly Tyr Ile Glu Arg Ala Ser Thr
        1635                1640                1645

 agc aca ggt ggt gcc aat caa gct gat gag aag tac ttc aaa tgt gac     4992
 Ser Thr Gly Gly Ala Asn Gln Ala Asp Glu Lys Tyr Phe Lys Cys Asp
    1650                1655                1660

 gtc tgt ggg cag ctc ttc aat gac cgc ctg tcc ctc gcc aga cac cag     5040
 Val Cys Gly Gln Leu Phe Asn Asp Arg Leu Ser Leu Ala Arg His Gln
1665                1670                1675                1680

 aat acc cac act ggc tga gggcat ggggtaaagg ttagaaaacc ttcacctagg     5094
 Asn Thr His Thr Gly 
                1685

 acttgaccct taccaaacca cagagaatcc aaaccaatcc atgataatgt cagtaggaga   5154

 cttaacctta gtgtgttaca cacctgactt aacatctcta aactcagatt gaaaagagac   5214

 cgaatgtgca gattccacag tcttaagctt tccccttcag atgtcagtgt ctgcatgtgg   5274

 gaaagccata gcacacatct tacctttcca agtaatcaga ttgagaaaac cctatgagta   5334

 ttccagacta cagagtttgc ccaaatcaac tgtaaatgac acttgtgtaa cgtatatata   5394

 gtgtttcatg aggtgtatat aaaatagcaa attatgacag aacagtgatc acatatattt   5454

 ggatttatat gatatacagt tacagtttac tctgcagagg taccttacct ggtattcttt   5514

 gaattttttt tttttttgga ggaggaagag agcaacaaat ttgattatat ttttaagtgt   5574

 cttagatcct gagaaagatt tattgtgcat tatttgaacc ctgtcaatat ctttttgagt   5634

 aattgttttg tttcttaccc ttaaatagtc ttgtgaagct gtaggcatga tagataacat   5694

 ggcttttact ccttactgtt tgaaaagata agtactttag cttctttctg cagccatttc   5754

 atctgcgcca acactttgga acctaatact gtgtaaggct ttacaatata cggattggct   5814

 ttttgtgacc cagattgatt ggttgccaca tgttatgttt gttgaagtgg ttctcatgca   5874

 aaaatattac acatttgtgt tctgggtttt tttttttttt taaccaactc aatatgtgtt   5934

 tgatgatagt gaattgataa aacccgaagc ttttccctgt aaatcttaca tctttgcctt   5994

 taaagaatgg gttacaacca tcactagatc acagtagtgc ctaatgaagg ttgagaaccg   6054

 taggagaggc tctcatgctg taaataatgt tgcaggctaa taacctttca tcacttcctt   6114

 tgtgcgcttc ctgccttaag tgacaagtag caacatggct tgggtcccct gtgcagcatc   6174

 agcttatgct gccacaagtc agtttgcacc ctaggtgccc aggagctagt atccttagat   6234

 ctttctatcg ctaacttaat tctcttcgtt atttatctga ccctctaact ccatgtctaa   6294

 cttgcattaa aaaaaaaaaa a                                             6315




      <210> 419
      <211> 1367
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (476)..(1367)

      <400> 419
 tttttcttat tcgtggtttt ttgtttcatt ggtgtttatc tgcagaactt tgtttccttc     60

 tgctcaattc ataatcagag tgcttttcct cttggctgaa tccataagtg tttatgcaaa    120

 aagaggttgg gcatagagcc aggcgactga tgacacccgg ctcatctggc aagtggatat    180

 caaattgttg tgtctcgttc tgccattccc ggctcctgct gtggggctgg gccatctgcc    240

 aactctgcaa ggagctggcg ggaaaccgct gccagcagag tgaacccacg gcccgggtca    300

 gtccgcctcg gcatagcact ccagctggcc cccagtgcct tttggggaca catctgtatt    360

 gccaggcagg gctgtgggag ggccgcctgc ctcctgtcca tcacaaggaa aacctaacct    420

 tgtcctgctt cccttccagg cagcctgtgt ggagattgct gcattcacct ttaat atg     478
                                                              Met
                                                                1

 gct aaa atg ttt tcc ttc aat gac agt aat gct gcc aga atc cat caa      526
 Ala Lys Met Phe Ser Phe Asn Asp Ser Asn Ala Ala Arg Ile His Gln
               5                  10                  15

 gac acc cag gaa ctg atg tgc ttt ggc aga tgg tgc tgg aaa gat ggg      574
 Asp Thr Gln Glu Leu Met Cys Phe Gly Arg Trp Cys Trp Lys Asp Gly
          20                  25                  30

 att ccc ggc agc ctt tgc atc cct tgc tca cag ccc atg agc atc tcc      622
 Ile Pro Gly Ser Leu Cys Ile Pro Cys Ser Gln Pro Met Ser Ile Ser
      35                  40                  45

 act gtc cag cag ggg aag aaa gca gca tca tcc cac tat tcc agg gga      670
 Thr Val Gln Gln Gly Lys Lys Ala Ala Ser Ser His Tyr Ser Arg Gly
  50                  55                  60                  65

 ggt gct aaa tac gag ggt gag gct gtc aag cgg tcc ctg gtg gag tcc      718
 Gly Ala Lys Tyr Glu Gly Glu Ala Val Lys Arg Ser Leu Val Glu Ser
                  70                  75                  80

 tac act cac cca aac agc aac gag aca gag cgg agg gag aac atc gat      766
 Tyr Thr His Pro Asn Ser Asn Glu Thr Glu Arg Arg Glu Asn Ile Asp
              85                  90                  95

 acc gtc atg aac tgc ttc agc aca gaa gac ttt gac ttt gtg act ctg      814
 Thr Val Met Asn Cys Phe Ser Thr Glu Asp Phe Asp Phe Val Thr Leu
         100                 105                 110

 tac tac aga gag cca gat aac gtg gga cat cga ttc ggg cca gag gca      862
 Tyr Tyr Arg Glu Pro Asp Asn Val Gly His Arg Phe Gly Pro Glu Ala
     115                 120                 125

 gag aag agg aag ttg atg att cag caa atc ggc agg acc atc gtg tat      910
 Glu Lys Arg Lys Leu Met Ile Gln Gln Ile Gly Arg Thr Ile Val Tyr
 130                 135                 140                 145

 ctg gtg gga gcc act gag aag cac agc ctg cag agc acc tca gca cca      958
 Leu Val Gly Ala Thr Glu Lys His Ser Leu Gln Ser Thr Ser Ala Pro
                 150                 155                 160

 tgg ggt gac cac cgt gaa gaa gag acc caa cgt caa caa gat ccc ttg     1006
 Trp Gly Asp His Arg Glu Glu Glu Thr Gln Arg Gln Gln Asp Pro Leu
             165                 170                 175

 acc aac tac atc aag ttc agg gtc tgg gtc aag ttt gat att gcg ggc     1054
 Thr Asn Tyr Ile Lys Phe Arg Val Trp Val Lys Phe Asp Ile Ala Gly
         180                 185                 190

 tac ggt ggc ttt ggg ctg ccc cta ccc aaa ttg ggg caa gag gaa gcc     1102
 Tyr Gly Gly Phe Gly Leu Pro Leu Pro Lys Leu Gly Gln Glu Glu Ala
     195                 200                 205

 ctt tac cag gca ctg aag aat gcg cac cct cac ctc cag gtc tac aag     1150
 Leu Tyr Gln Ala Leu Lys Asn Ala His Pro His Leu Gln Val Tyr Lys
 210                 215                 220                 225

 aag gag gag ttt cca gaa cac ttc cat ctc gct aaa cat gac cgg gtt     1198
 Lys Glu Glu Phe Pro Glu His Phe His Leu Ala Lys His Asp Arg Val
                 230                 235                 240

 ctg cca atc gtg att ttt cag aga att ata atg tgt ttc aac aaa ggc     1246
 Leu Pro Ile Val Ile Phe Gln Arg Ile Ile Met Cys Phe Asn Lys Gly
             245                 250                 255

 agc cat ggc ttt gat aat gtc ctc atg gac atg aac atc ata ttc aga     1294
 Ser His Gly Phe Asp Asn Val Leu Met Asp Met Asn Ile Ile Phe Arg
         260                 265                 270

 gct ttc ggg cca gat ttc aag agg aat cgc ctg gcc gag cct ttt aac     1342
 Ala Phe Gly Pro Asp Phe Lys Arg Asn Arg Leu Ala Glu Pro Phe Asn
     275                 280                 285

 agc atc cac atc tac cca ttc gtg t                                   1367
 Ser Ile His Ile Tyr Pro Phe Val 
 290                 295





      <210> 420
      <211> 1385
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (652)..(1338)

      <400> 420
 atggcttctt caaagctccg agaacccgtg gatgaagttt ttgacctgga cttggctgtg     60

 ccagagacgg ccagactgga cagcagttta cacaaggccc gggcccaact gttggccaag    120

 ggccggagac accggccatc ccgctccagg cttcgggaca gtgccagctc cgcggaggat    180

 ggtgaaggct cggatgggcc cggaggcaag gtgaccgatg gctgcgggag ccccctgcac    240

 cggctgcgct cgcctttgca ctcaggcccg gggtccccgg ccgggggctc tttctgcctg    300

 gatcctccgg ggttgcggcg cagcctggac gaggacgagc cgccgccctc gccgctcaca    360

 cgctaccggc ccctgcacaa cgctgcgtcg cacgagggcc tggccgccgc ctcctgctct    420

 ccgccgcgct ccgcgccctc ctccgacagc tcccccagct tcgtgcgccg ccacccgcgc    480

 gcagagccgc acagcgaaga tgacagccgt gacgccagtc ctcctgagcc cgccagcccc    540

 accatcggcc tcgataagaa gactcgccga aagttcctgg acctgggggt caccctgcgc    600

 cgagcatcca cgggcaagag ccggaaggag aaaggcagca accgactgtc c atg ggc     657
                                                          Met Gly
                                                            1

 agc agg gag tca gtg gag ggg tcc ggc agg tca ggg ggc tcc ccg ttc      705
 Ser Arg Glu Ser Val Glu Gly Ser Gly Arg Ser Gly Gly Ser Pro Phe
           5                  10                  15

 ctg cct ttt tcc tgg ttc acg gac agc ggc aag ggc tca gca tcc tcg      753
 Leu Pro Phe Ser Trp Phe Thr Asp Ser Gly Lys Gly Ser Ala Ser Ser
      20                  25                  30

 ggt agc acc acc tcc ccc acc tgc tcc cct aaa cac gag ggc ttc agc      801
 Gly Ser Thr Thr Ser Pro Thr Cys Ser Pro Lys His Glu Gly Phe Ser
  35                  40                  45                  50

 cct aag aag tca gct tcc cag gcc cag ctc ctg gct cat gca cag gag      849
 Pro Lys Lys Ser Ala Ser Gln Ala Gln Leu Leu Ala His Ala Gln Glu
                  55                  60                  65

 gca ctg agc aac tcc tgg tgc cta gtc cag gac ttc ggc tcc acc cag      897
 Ala Leu Ser Asn Ser Trp Cys Leu Val Gln Asp Phe Gly Ser Thr Gln
              70                  75                  80

 ata ggg atg gaa tcc act ctg agt gat gac tcc acg ccc ccc agc agt      945
 Ile Gly Met Glu Ser Thr Leu Ser Asp Asp Ser Thr Pro Pro Ser Ser
          85                  90                  95

 agc ccc aag atc ccc agt ggg ccc tgg cag gag gcc aaa tgt tct tac      993
 Ser Pro Lys Ile Pro Ser Gly Pro Trp Gln Glu Ala Lys Cys Ser Tyr
     100                 105                 110

 ccc tac cac acg ctg tct cag tct tca gat gag ttc ctg gat gaa ccc     1041
 Pro Tyr His Thr Leu Ser Gln Ser Ser Asp Glu Phe Leu Asp Glu Pro
 115                 120                 125                 130

 ctc ccc cct gtc cac cac tgg acc agc cag cag gtg ggc cag tgg ctg     1089
 Leu Pro Pro Val His His Trp Thr Ser Gln Gln Val Gly Gln Trp Leu
                 135                 140                 145

 cag agc ctc aac ctg gaa cag tat gct gct gag ttt gct gca cgg cag     1137
 Gln Ser Leu Asn Leu Glu Gln Tyr Ala Ala Glu Phe Ala Ala Arg Gln
             150                 155                 160

 gta gac ggg ccg cag ctg ctg cag ctg gac gga agc aaa cta aag agc     1185
 Val Asp Gly Pro Gln Leu Leu Gln Leu Asp Gly Ser Lys Leu Lys Ser
         165                 170                 175

 ctg ggg ctc agc aac tct cat gac cgg gca ctg gtg aag cgc aag ttg     1233
 Leu Gly Leu Ser Asn Ser His Asp Arg Ala Leu Val Lys Arg Lys Leu
     180                 185                 190

 aag gag atg gca gca gct gcc gag aag gag cgc aag gcc cag gag aag     1281
 Lys Glu Met Ala Ala Ala Ala Glu Lys Glu Arg Lys Ala Gln Glu Lys
 195                 200                 205                 210

 gct gcg cgg cag cgg gag aag ctc cgg cgc cga gag cag gag gcc aag     1329
 Ala Ala Arg Gln Arg Glu Lys Leu Arg Arg Arg Glu Gln Glu Ala Lys
                 215                 220                 225

 aag agc tag gggaggg tgcacaggcg ctggcacccg gcaggggcag ccactggctc     1385
 Lys Ser 






      <210> 421
      <211> 417
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (144)..(359)

      <400> 421
 atttggccct cgaggccaag aattcggcac gaggaagtta ttgacagttt cagtttggga     60

 agatggaagc attctggaga tgggtggaga tgtttgctca acagtgtgaa ggtgcttgat    120

 acccctgagc tgtaccctta aca    atg gtt aag ata cag cca tta tgg aaa     170
                              Met Val Lys Ile Gln Pro Leu Trp Lys
                                1               5

 aga gta tgg agg ttc cac aac aaa tca aaa cta gaa cta ccg tgt gat      218
 Arg Val Trp Arg Phe His Asn Lys Ser Lys Leu Glu Leu Pro Cys Asp
  10                  15                  20                  25

 cca gca atc tca ttg ctg agt atg tat cca aag gaa atg aaa tca gtg      266
 Pro Ala Ile Ser Leu Leu Ser Met Tyr Pro Lys Glu Met Lys Ser Val
                  30                  35                  40

 tgt caa aga gac gtc tgc act ccc agg ctc agc acg gca cca ctc aca      314
 Cys Gln Arg Asp Val Cys Thr Pro Arg Leu Ser Thr Ala Pro Leu Thr
              45                  50                  55

 ata gcc ggg atg tgg aac cca cct aag cgc tcg tcg atg gat tag gtg      362
 Ile Ala Gly Met Trp Asn Pro Pro Lys Arg Ser Ser Met Asp 
          60                  65                  70

 gataaagaaa acatcgcgaa ttactgaata ctctggagcc ttaaaaagaa ggaag         417




      <210> 422
      <211> 1923
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (357)..(1388)

      <400> 422
 cgtcagggga tgcaagtgag gaattgggct ggcggccaag gggttggggg cccaaggcct     60

 gtacccaggg gttcttccgc aagttgctgg gctccaccca tcctgggcct cctggggcgg    120

 agccctggac ccccaaagac gcccattctg gcatctggga ctcctggtgg ccttttctgg    180

 ggttctcagg gcccggtgct cttggctttc tcggcagcgg ctccctgtct ggtgccctct    240

 cctgctgcga ggactcggcc cggggctcgg gcccgcccaa ggcccctacg gtggccgagg    300

 gtcccagctc ctgccttcgg cggaacgtga tcagcgagag ggagcgcagg aagcgg        356                                                                 
 atg tcg ttg agc tgt gag cgt ctg cgg gcc ctg ctg ccc cag ttc gat      404
 Met Ser Leu Ser Cys Glu Arg Leu Arg Ala Leu Leu Pro Gln Phe Asp
   1               5                  10                  15

 ggc cgg cgg gag gac atg gcc tcg gtc ctg gag atg tct gtg cag ttc      452
 Gly Arg Arg Glu Asp Met Ala Ser Val Leu Glu Met Ser Val Gln Phe
              20                  25                  30

 ctg cgg ctt gcc agc gcc ctg ggg ccc agt cag gag cag cac gct gtg      500
 Leu Arg Leu Ala Ser Ala Leu Gly Pro Ser Gln Glu Gln His Ala Val
          35                  40                  45

 agt tgt aag ggt aga cgc cgt cag tcc tcc ggc atc acg gtg atg gga      548
 Ser Cys Lys Gly Arg Arg Arg Gln Ser Ser Gly Ile Thr Val Met Gly
      50                  55                  60

 cat ctc acc acc ttg cag gca att ctt gct tcc tcc aag gaa atg tgg      596
 His Leu Thr Thr Leu Gln Ala Ile Leu Ala Ser Ser Lys Glu Met Trp
  65                  70                  75                  80

 cac tcg ttg cag gag gat gtt tta cag ttg acg ttg tcg agt cag att      644
 His Ser Leu Gln Glu Asp Val Leu Gln Leu Thr Leu Ser Ser Gln Ile
                  85                  90                  95

 caa gca ggt gtg cca gac cct ggg acg gga gcg tcc agc ggg act cga      692
 Gln Ala Gly Val Pro Asp Pro Gly Thr Gly Ala Ser Ser Gly Thr Arg
             100                 105                 110

 acc cca gat gtg aag gcg ttt ctg gaa agt cct tgg tcc ctg gat cca      740
 Thr Pro Asp Val Lys Ala Phe Leu Glu Ser Pro Trp Ser Leu Asp Pro
         115                 120                 125

 gcg tcg gcc agc cca gag ccc gtg ccg cac atc ctt gcg tcc tcc agg      788
 Ala Ser Ala Ser Pro Glu Pro Val Pro His Ile Leu Ala Ser Ser Arg
     130                 135                 140

 cag tgg gac ccc gcg agc tgc acg tcc ctg ggc acg gac aag tgt gag      836
 Gln Trp Asp Pro Ala Ser Cys Thr Ser Leu Gly Thr Asp Lys Cys Glu
 145                 150                 155                 160

 gca ctg ttg ggg ctg tgc cag gtg cgg ggt ggg ctg ccc cct ttc tca      884
 Ala Leu Leu Gly Leu Cys Gln Val Arg Gly Gly Leu Pro Pro Phe Ser
                 165                 170                 175

 gaa cct tcc agc ctg gtg ccg tgg ccc cca ggc cgg agt ctt cct aag      932
 Glu Pro Ser Ser Leu Val Pro Trp Pro Pro Gly Arg Ser Leu Pro Lys
             180                 185                 190

 gct gtg agg cca ccc ctg tcc tgg cct ccg ttc tcg cag cag cag acc      980
 Ala Val Arg Pro Pro Leu Ser Trp Pro Pro Phe Ser Gln Gln Gln Thr
         195                 200                 205

 ttg ccc gtg atg agc ggg gag gcc ctt ggc tgg ctg ggc cag gct ggg     1028
 Leu Pro Val Met Ser Gly Glu Ala Leu Gly Trp Leu Gly Gln Ala Gly
     210                 215                 220

 ccc ctg gcc atg ggg gct gca cct ctg ggg gag cca gcc aag gag gac     1076
 Pro Leu Ala Met Gly Ala Ala Pro Leu Gly Glu Pro Ala Lys Glu Asp
 225                 230                 235                 240

 ccc atg ctg gcg cag gag gcc ggg tct gcg ttg ggg tct gat gtg gac     1124
 Pro Met Leu Ala Gln Glu Ala Gly Ser Ala Leu Gly Ser Asp Val Asp
                 245                 250                 255

 gat ggg acg tcc ttc ctg ctg act gct ggt ccc agc tcg tgg ccg ggg     1172
 Asp Gly Thr Ser Phe Leu Leu Thr Ala Gly Pro Ser Ser Trp Pro Gly
             260                 265                 270

 tct ctg gag ggt cga gga ggc agt ggc cct gca tgg gcc cca gct gag     1220
 Ser Leu Glu Gly Arg Gly Gly Ser Gly Pro Ala Trp Ala Pro Ala Glu
         275                 280                 285

 agc agt cca ctg gat gtt gga gag cca ggc ttc cta ggg gac cct gag     1268
 Ser Ser Pro Leu Asp Val Gly Glu Pro Gly Phe Leu Gly Asp Pro Glu
     290                 295                 300

 ctt ggc tcc cag gag ctc cag gac agc cct ctg gag ccg tgg ggc ctg     1316
 Leu Gly Ser Gln Glu Leu Gln Asp Ser Pro Leu Glu Pro Trp Gly Leu
 305                 310                 315                 320

 gat gtg gac tgt gca ggc ctg gcc ctg aag gac gag gtg gag agc atc     1364
 Asp Val Asp Cys Ala Gly Leu Ala Leu Lys Asp Glu Val Glu Ser Ile
                 325                 330                 335

 ttc cct gac ttc ttt gcc tgc tag cagccaggct gtggagagga ggcgggcggg    1418
 Phe Pro Asp Phe Phe Ala Cys 
             340

 gccggtggat ctggagccgt gtgtgtccct gtcgcgtgct tgggcatttt attttgggtt   1478

 tgggttgcag ctgcacccta atttgagcga ggcttacagg ctgtgagaag aggatagtga   1538

 atattaaaga gggaaagcag ttttcctgga ggaagcaaaa cctgtgtggc ttctgtgtaa   1598

 ttagcctgat tcatcaggcg gatcgcgcca cctccgttca gcgttcaggc agctgccggg   1658

 gattttgttc tccaaagttc tcagcactgc gaaatcccgg aataacccag tcctggtgcc   1718

 ctggggtagg ggtgctgtgg gacctgctcc ctggaggcga tgtggcctca cggtcttggt   1778

 gcctggaggc tgctctgtga gctgcttttc ctgctcgttg ccactcagag ctgttcttta   1838

 gccacagcac aggtggtgct ggtctccgaa cccggatgct cagggtctca ccctgctatc   1898

 cccatctgga tagcacgccc accag                                         1923




      <210> 423
      <211> 1010
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (382)..(681)

      <400> 423
 agcacgcagc ttgagatccg agaacgggca gactgcctcc tcaagtgggt ccctgacccc     60

 cgagtagcct aactgggagg caccccccag taggggcgca ctgacacttc acacggctgg    120

 gtactcctct gagacaaaac ctccagaaga acgattagac agcagcattt gcggttcacc    180

 aatatccgct gttctgcagc cactactgcc tgatacccag acaaacaggg tctggagtgg    240

 acccccagca aactccaaca cacctgcagc tgagggtcct gactgtcgga aggaaaacta    300

 acaaacagaa aggacaacca caccaaaacc ccatctgtac atcaccatca tcaaaaacca    360

 aaggtagata aaaccacaag g  atg ggg aga att cag agc aca aaa gct gaa     411
                          Met Gly Arg Ile Gln Ser Thr Lys Ala Glu
                            1               5                  10

 aat tct aaa aat gag agc acc tct tct cct cca aag gaa cac agc acc      459
 Asn Ser Lys Asn Glu Ser Thr Ser Ser Pro Pro Lys Glu His Ser Thr
                  15                  20                  25

 tca cca gca acg gaa caa agc cgg atg gag aat gac ttt gac gag ttg      507
 Ser Pro Ala Thr Glu Gln Ser Arg Met Glu Asn Asp Phe Asp Glu Leu
              30                  35                  40

 aga gaa gac ttc aga aga tca gta ata aca aac ttc tct gag tta aag      555
 Arg Glu Asp Phe Arg Arg Ser Val Ile Thr Asn Phe Ser Glu Leu Lys
          45                  50                  55

 gag gat gtt cga acc ctt tgt aaa gaa gct aaa aac ctt gaa aaa aga      603
 Glu Asp Val Arg Thr Leu Cys Lys Glu Ala Lys Asn Leu Glu Lys Arg
      60                  65                  70

 tta gat gaa tgg cta act aga ata aac agc ata gag aag acc tta aat      651
 Leu Asp Glu Trp Leu Thr Arg Ile Asn Ser Ile Glu Lys Thr Leu Asn
  75                  80                  85                  90

 gac ctg atg gag ctg aaa acc atg gca tga g aactacatga cacatgcaca      702
 Asp Leu Met Glu Leu Lys Thr Met Ala 
                  95

 agcttcagta gccgagttga tcaagtggaa gaaaggttat cagtgattta agatcaaatg    762

 aatgaaatga agtgagaaga gaagtttaga gaaaaaaaga gtaaaaataa atgaataaag    822

 ctgccaagaa atatgggact aggtgaaaag accaaatata catctgatta ctgtacctga    882

 aagtgatggg gagaaaggaa ccaagttgga aaacactctg caggatatta tccaggagaa    942

 cttccacaac atagcaaggc aggctaacat tcaaattcag gaaatacaga gaatgccaca   1002

 cagatact                                                            1010




      <210> 424
      <211> 953
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (129)..(728)

      <400> 424
 atttcatacg actcactata gggaatttgg ccctcgagca gtaattcggc acgagcaatc     60

 tgctgaaaac gcacaagttt attgttggac aagatgaaga ttcccttcat agtgttccag    120

 ttgcacaa atg ggt aac tat cag gaa tat ctg aag aca ttg gct tct cca     170
          Met Gly Asn Tyr Gln Glu Tyr Leu Lys Thr Leu Ala Ser Pro
            1               5                  10

 ctg cga gag att gat cca gac caa ccc aaa aga ctg cat act ttt ggc      218
 Leu Arg Glu Ile Asp Pro Asp Gln Pro Lys Arg Leu His Thr Phe Gly
  15                  20                  25                  30

 aat ccg ttt aaa caa gat aag aag gga atg atg att gat gaa gca gat      266
 Asn Pro Phe Lys Gln Asp Lys Lys Gly Met Met Ile Asp Glu Ala Asp
                  35                  40                  45

 gag ttt gta gca ggg cca caa aac aaa gtg aaa cgt cca ggg gaa ccc      314
 Glu Phe Val Ala Gly Pro Gln Asn Lys Val Lys Arg Pro Gly Glu Pro
              50                  55                  60

 aac agt cct atg tca tct aag aga agg cgg aat gct act atc att cac      362
 Asn Ser Pro Met Ser Ser Lys Arg Arg Arg Asn Ala Thr Ile Ile His
          65                  70                  75

 gat ggc cat gag gag aag atg gaa aat ggt cag atc aca cct gat ggc      410
 Asp Gly His Glu Glu Lys Met Glu Asn Gly Gln Ile Thr Pro Asp Gly
      80                  85                  90

 ttc ctg tca aaa tct gct cca tca gag ctt ata aat atg aca gga gat      458
 Phe Leu Ser Lys Ser Ala Pro Ser Glu Leu Ile Asn Met Thr Gly Asp
  95                 100                 105                 110

 ctt atg cca ccc aac caa gtg gat tct ctg tct gac gac ttc aca agt      506
 Leu Met Pro Pro Asn Gln Val Asp Ser Leu Ser Asp Asp Phe Thr Ser
                 115                 120                 125

 ctc agc aaa gat ggg ctg att caa aaa cct ggt agt aac gca ttt gta      554
 Leu Ser Lys Asp Gly Leu Ile Gln Lys Pro Gly Ser Asn Ala Phe Val
             130                 135                 140

 gga gga gcc aaa aac tgc agt ctc tcc gta gat gac caa aaa gac cca      602
 Gly Gly Ala Lys Asn Cys Ser Leu Ser Val Asp Asp Gln Lys Asp Pro
         145                 150                 155

 gta gca tct act ttg gga gct atg cca aat aca tta caa atc act cct      650
 Val Ala Ser Thr Leu Gly Ala Met Pro Asn Thr Leu Gln Ile Thr Pro
     160                 165                 170

 gct atg gca caa gga atc aat gct gat ata aaa cat caa tta atg aag      698
 Ala Met Ala Gln Gly Ile Asn Ala Asp Ile Lys His Gln Leu Met Lys
 175                 180                 185                 190

 gaa gtt cga aag ttt ggt cga agt aag tag g gaaagaacat ctatcaataa      749
 Glu Val Arg Lys Phe Gly Arg Ser Lys 
                 195

 tgcaccagga gggttctctc attctgtgat tcactataga ttcaagctat cccttgaggt    809

 acactggggg caatattggg ctttcacata atttaaggca gttcctcttg ttttaactaa    869

 aaaggtacag cctatatttt cctgtttttt ccccttattt cttggaatgt ttccttttgc    929

 tgccgcaaca agttatcaaa agat                                           953




      <210> 425
      <211> 1818
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (417)..(1058)

      <220>
      <221> misc_feature
      <222> (1)...(1818)
      <223> n = a,t,c or g

      <400> 425
 tttcgtccgg aacggcggca cggggttgtt gtgggggtca gtcccccggg gactggaggg     60

 agacgcggca cgcggcctct gcgaccctat gaactctgac cccagctccc acactgtcgc    120

 ctatcaccgg cccactctcc gtgccgcgtg tcccttaaaa gctggggcct gggacaggaa    180

 cgacagacaa tgcagccaat ggcgtcacgc gcggtgcccc gctacccaat cgaaaggcgt    240

 ggctgaggga aacgcggtgg gaaccgcccc cgactccagg cgactccttg gccgggcggg    300

 ggagagcgtc cccgtcagct gagagcatcc tcactcggtc agttcctcgg gcgagttacg    360

 gggacgacct gcgggagcac gcgggcagtg gccggacgct gaagcccagg agagcg        416                                                                 
 atg gag acg tat gcg gag gtt ggg aag gag ggc aag cct tcc tgt gca      464
 Met Glu Thr Tyr Ala Glu Val Gly Lys Glu Gly Lys Pro Ser Cys Ala
   1               5                  10                  15

 tcg gtg gat ctg cag gga gac agc tcc tta cag gtg gag att tct gac      512
 Ser Val Asp Leu Gln Gly Asp Ser Ser Leu Gln Val Glu Ile Ser Asp
              20                  25                  30

 gca gtg agt gag cgg gac aag gtg aaa ttc act gtt caa aca aag agc      560
 Ala Val Ser Glu Arg Asp Lys Val Lys Phe Thr Val Gln Thr Lys Ser
          35                  40                  45

 tgc ctc cct cac ttc gcc cag acc gag ttc tca gtc gtg cgg cag cac      608
 Cys Leu Pro His Phe Ala Gln Thr Glu Phe Ser Val Val Arg Gln His
      50                  55                  60

 gag gag ttc atc tgg ctg cat gat gcc tac gtg gag aat gag gag tac      656
 Glu Glu Phe Ile Trp Leu His Asp Ala Tyr Val Glu Asn Glu Glu Tyr
  65                  70                  75                  80

 gcc ggc ctc atc atc ccc cca gcc cct ccg agg cca gac ttt gag gct      704
 Ala Gly Leu Ile Ile Pro Pro Ala Pro Pro Arg Pro Asp Phe Glu Ala
                  85                  90                  95

 tcg agg gaa aag cta cag aaa ttg ggc gag ggg gac agc tct gtc act      752
 Ser Arg Glu Lys Leu Gln Lys Leu Gly Glu Gly Asp Ser Ser Val Thr
             100                 105                 110

 cgg gaa gag ttt gcc aag atg aag cag gag ctg gaa gcg gag tac ctg      800
 Arg Glu Glu Phe Ala Lys Met Lys Gln Glu Leu Glu Ala Glu Tyr Leu
         115                 120                 125

 gcc atc ttt aag aag aca gtt gcg atg cac gaa gtc ttt ctg cag cgc      848
 Ala Ile Phe Lys Lys Thr Val Ala Met His Glu Val Phe Leu Gln Arg
     130                 135                 140

 ctg gcg gcc cac ccc acc ctg cgt cga gac cac aac ttc ttt gtg ttt      896
 Leu Ala Ala His Pro Thr Leu Arg Arg Asp His Asn Phe Phe Val Phe
 145                 150                 155                 160

 ttg gaa tat gga cag gat ctg agt gtc cgg ggg aag aac agg aag gag      944
 Leu Glu Tyr Gly Gln Asp Leu Ser Val Arg Gly Lys Asn Arg Lys Glu
                 165                 170                 175

 ctc ctc gga ggg ttt ctg agg aat att gtg aag tcc gcg gat gaa gcc      992
 Leu Leu Gly Gly Phe Leu Arg Asn Ile Val Lys Ser Ala Asp Glu Ala
             180                 185                 190

 ctc atc acg ggc atg tca ggg ctc aag gcc tgg cag acg att ata tcc     1040
 Leu Ile Thr Gly Met Ser Gly Leu Lys Ala Trp Gln Thr Ile Ile Ser
         195                 200                 205

 cta tct cag ctg cgc tga gcagtc tgggaacaca ggaagtcaac cagctaagga     1094
 Leu Ser Gln Leu Arg 
     210

 cgagcttcct caaattggca gagctctttg aacggctgag gaagctggag ggccgggtgg   1154

 cttccgatga ggacctgaag ctgtcagaca tgctgaggta ctacatgcgt gactcacagg   1214

 cagccaagga cctgctgtac cggcggctgc gggcactggc cgactacgag aatgccaaca   1274

 aggcgctgga caaggcgcgc accaggaacc gggaggtgcg gcccgccgag agccaccagc   1334

 agctgtgctg ccaacgcttc gagcgcctct ccgactccgc caagcaagag ctcatggact   1394

 tcaagtcccg ccgggtctcc tcttttcgaa agaatctcat tgagctggca gagctggagc   1454

 tcaaacacgc caaggccagc accctgattc tccggaacac ccttgttgcc ctaaaggggg   1514

 agccttagag tagccagagc tcagccagac cctaatctgg gatctccagt gaccagggta   1574

 tcccagaccc ctctctccgg caagatgtct ccttccctag cagtgccact agccacaccc   1634

 tcactctgcc ccacatcctc tcagggaaag cccaaacccc ctatcaccac caccacaggt   1694

 gccaggccct gcaagacaca gggcagcatg ggcatcataa ctggccacan tcagcagagc   1754

 cccagggacc ctgacaacct tccccaggaa gctgaggaac agcctctacc ctcacccata   1814

 gcct                                                                1818




      <210> 426
      <211> 445
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (30)..(395)

      <400> 426
 ccgggctgtt cctgtaaggc ggggagaca  atg agt aaa ctc tcc ttc cga gcg      53
                                  Met Ser Lys Leu Ser Phe Arg Ala
                                    1               5

 cgg gcg ctg gac gcc gcc aag ccg ctg cct atc tac cgc ggc aag gac      101
 Arg Ala Leu Asp Ala Ala Lys Pro Leu Pro Ile Tyr Arg Gly Lys Asp
      10                  15                  20

 atg cct gat ctc aac gac tgc gtc tcc atc aac cgg gcc gtg ccc cag      149
 Met Pro Asp Leu Asn Asp Cys Val Ser Ile Asn Arg Ala Val Pro Gln
  25                  30                  35                  40

 atg ccc acc ggg atg gag aag gag gag gaa tcg gaa cat cat tta cag      197
 Met Pro Thr Gly Met Glu Lys Glu Glu Glu Ser Glu His His Leu Gln
                  45                  50                  55

 cga gca att tca gca cag caa gtg ttt aga gaa aaa aaa gag agt atg      245
 Arg Ala Ile Ser Ala Gln Gln Val Phe Arg Glu Lys Lys Glu Ser Met
              60                  65                  70

 gtc att cct gtt cct gag gca gag agc aac gtc aac tat tac aat cgc      293
 Val Ile Pro Val Pro Glu Ala Glu Ser Asn Val Asn Tyr Tyr Asn Arg
          75                  80                  85

 ttg tac aaa gga gag ttt aaa cag cca aaa cag ttc att cat att cag      341
 Leu Tyr Lys Gly Glu Phe Lys Gln Pro Lys Gln Phe Ile His Ile Gln
      90                  95                 100

 ctg aaa ttg cat ctt aaa ttg ctg ttg ttc agg att gaa gtc ttg ttc      389
 Leu Lys Leu His Leu Lys Leu Leu Leu Phe Arg Ile Glu Val Leu Phe
 105                 110                 115                 120

 ttc taa agagaatttt catttgtttc tgccaggcat ttggggacac taccaaccgg       445
 Phe 






      <210> 427
      <211> 1225
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (174)..(716)

      <400> 427
 cggacgcgtg ggatggcccc aaggggcttg cagggcccat gggagagaaa ggcctccgag     60

 gagagactgg gcctcagggg cagaagggga ataagggtga cgtgggtccc actggtcctg    120

 aggggccaag gggcaacatt gggcctttgg gcccaactgg tttaccgggc ccc   atg     176
                                                              Met
                                                                1

 ggc cct att gga aag cct ggt ccc aag gga gaa gct gga ccc acg ggg      224
 Gly Pro Ile Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly
               5                  10                  15

 ccc cag ggt gag cca gga gtc cgg gga ata aga ggc tgg aaa gga gat      272
 Pro Gln Gly Glu Pro Gly Val Arg Gly Ile Arg Gly Trp Lys Gly Asp
          20                  25                  30

 cga gga gag aaa ggg aaa atc ggt gag act cta gtc ttg cca aaa agt      320
 Arg Gly Glu Lys Gly Lys Ile Gly Glu Thr Leu Val Leu Pro Lys Ser
      35                  40                  45

 gct ttc act gtg ggg ctc acg gtg ctg agc aag ttt cct tct tca gat      368
 Ala Phe Thr Val Gly Leu Thr Val Leu Ser Lys Phe Pro Ser Ser Asp
  50                  55                  60                  65

 atg ccc att aaa ttt gat aag atc ctg tat aac gaa ttc aac cat tat      416
 Met Pro Ile Lys Phe Asp Lys Ile Leu Tyr Asn Glu Phe Asn His Tyr
                  70                  75                  80

 gat aca gca gcg ggg aaa ttc acg tgc cac att gct ggg gtc tat tac      464
 Asp Thr Ala Ala Gly Lys Phe Thr Cys His Ile Ala Gly Val Tyr Tyr
              85                  90                  95

 ttc acc tac cac atc act gtt ttc tcc agg aat gtt cag gtg tct ttg      512
 Phe Thr Tyr His Ile Thr Val Phe Ser Arg Asn Val Gln Val Ser Leu
         100                 105                 110

 gtc aaa aat gga gta aaa ata ctg cac acc aaa gat gct tac atg agc      560
 Val Lys Asn Gly Val Lys Ile Leu His Thr Lys Asp Ala Tyr Met Ser
     115                 120                 125

 tct gag gac cag gcc tct ggc ggc att gtc ctg cag ctg aag ctc ggg      608
 Ser Glu Asp Gln Ala Ser Gly Gly Ile Val Leu Gln Leu Lys Leu Gly
 130                 135                 140                 145

 gat gag gtg tgg ctg cag gtg aca gga gga gag agg ttc aat ggc ttg      656
 Asp Glu Val Trp Leu Gln Val Thr Gly Gly Glu Arg Phe Asn Gly Leu
                 150                 155                 160

 ttt gct gat gag gac gat gac aca act ttc aca ggg ttc ctt ctg ttc      704
 Phe Ala Asp Glu Asp Asp Asp Thr Thr Phe Thr Gly Phe Leu Leu Phe
             165                 170                 175

 agc agc ccg tga cag aggagagttt aaaaatccgc cacaccatcc atcagaatca      759
 Ser Ser Pro 
         180

 gcttgggatg aacttattca gatggtttta ctttattaat tcctccaatt attacaataa    819

 tcataaaaag gtgaaaatgg aaaagttatt cccaaaactg attctgtgta acttactatt    879

 tttccaggag taaatattta aaatagctgc atggtttatt ctaatttatt tcacatttct    939

 tattcctatt atctgaagaa tccctcgtct gtgcgtttct tgtgggaaga gtgttttaat    999

 atcattttag tgctctgagg agtcatatga agatgtatcc ctcatctgtg tttctgagga   1059

 cattaagggg aaattagagg gaaatgttta ttcaatttag tactagcaac agctttaagc   1119

 tggtgatgct gtcatactcc agaaagctgt agacactgct cattttgtct tttaaaaaaa   1179

 ttttatttta ttttaagttg tgggatacat atgcaaaaca tgcatg                  1225




      <210> 428
      <211> 3998
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (255)..(2948)

      <400> 428
 gcataagttt ttttttctta aaaaaacggc atctgcttaa agggatttat gactaaaatt     60

 gcttattttt ctacagagtt gtctgctggt tctcagcttg aagaagattc tgaagtcctt    120

 attgatcctt tttcttggcg ttaccatttt ttgaagcaaa gttaacctag ctttctagtt    180

 tgagctttct ttttggccgt ctttaaaaaa aatttttttt ttaatctata aaatagacaa    240

 gagctagttc taca  atg tcc aag tca ttc cag cag tca tct ctc agt agg     290
                  Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser Arg
                    1               5                  10

 gac tca cag ggt cat ggg cgt gac ctg tct gcg gca gga ata ggc ctt      338
 Asp Ser Gln Gly His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu
          15                  20                  25

 ctt gct gct gct acc cag tct tta agt atg cca gca tct ctt gga agg      386
 Leu Ala Ala Ala Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly Arg
      30                  35                  40

 atg aac cag ggt act gca cgc ctt gct agt tta atg aat ctt gga atg      434
 Met Asn Gln Gly Thr Ala Arg Leu Ala Ser Leu Met Asn Leu Gly Met
  45                  50                  55                  60

 agt tct tca ttg aat caa caa gga gct cat agt gca ctg tct tct gct      482
 Ser Ser Ser Leu Asn Gln Gln Gly Ala His Ser Ala Leu Ser Ser Ala
                  65                  70                  75

 agt act tct tcc cat aat ttg cag tct ata ttt aac att gga agt aga      530
 Ser Thr Ser Ser His Asn Leu Gln Ser Ile Phe Asn Ile Gly Ser Arg
              80                  85                  90

 ggt cca ctc cct tta tct tct caa cac cgt gga gat gca gac cag gcc      578
 Gly Pro Leu Pro Leu Ser Ser Gln His Arg Gly Asp Ala Asp Gln Ala
          95                 100                 105

 agt aac att ttg gcc agc ttt ggt ctg tct gct aga gac tta gat gaa      626
 Ser Asn Ile Leu Ala Ser Phe Gly Leu Ser Ala Arg Asp Leu Asp Glu
     110                 115                 120

 ctg agt cgt tat cca gag gac aag att act cct gag aat ttg ccc caa      674
 Leu Ser Arg Tyr Pro Glu Asp Lys Ile Thr Pro Glu Asn Leu Pro Gln
 125                 130                 135                 140

 atc ctt cta cag ctt aaa agg agg aga act gaa gaa ggc cct acc ttg      722
 Ile Leu Leu Gln Leu Lys Arg Arg Arg Thr Glu Glu Gly Pro Thr Leu
                 145                 150                 155

 agt tat ggt aga gat ggc aga tct gct aca cgg gag cca cca tac aga      770
 Ser Tyr Gly Arg Asp Gly Arg Ser Ala Thr Arg Glu Pro Pro Tyr Arg
             160                 165                 170

 gta cct agg gat gat tgg gaa gaa aaa agg cac ttt aga aga gat agt      818
 Val Pro Arg Asp Asp Trp Glu Glu Lys Arg His Phe Arg Arg Asp Ser
         175                 180                 185

 ttt gat gat cgt ggt cct agt ctc aac cca gtg ctt gat tat gac cat      866
 Phe Asp Asp Arg Gly Pro Ser Leu Asn Pro Val Leu Asp Tyr Asp His
     190                 195                 200

 gga agt cgt tct caa gaa tct ggt tat tat gac aga atg gat tat gaa      914
 Gly Ser Arg Ser Gln Glu Ser Gly Tyr Tyr Asp Arg Met Asp Tyr Glu
 205                 210                 215                 220

 gat gac aga tta aga gat gga gaa agg tgt agg gat gat tct ttt ttt      962
 Asp Asp Arg Leu Arg Asp Gly Glu Arg Cys Arg Asp Asp Ser Phe Phe
                 225                 230                 235

 ggt gag acc tcg cat aac tat cat aaa ttt gac agt gag tat gag aga     1010
 Gly Glu Thr Ser His Asn Tyr His Lys Phe Asp Ser Glu Tyr Glu Arg
             240                 245                 250

 atg gga cgt ggt tct ggc ccc tta caa gag aga tct ctc ttt gag aaa     1058
 Met Gly Arg Gly Ser Gly Pro Leu Gln Glu Arg Ser Leu Phe Glu Lys
         255                 260                 265

 aag aga ggc gct cct tca agt agc aat att gta gac gtt cat tgg act     1106
 Lys Arg Gly Ala Pro Ser Ser Ser Asn Ile Val Asp Val His Trp Thr
     270                 275                 280

 ctt acc gaa agg gtt atc ccc atc tgt gct cta tat gtg att ggc cag     1154
 Leu Thr Glu Arg Val Ile Pro Ile Cys Ala Leu Tyr Val Ile Gly Gln
 285                 290                 295                 300

 gtc att cta ata agg agt gga gtc aac ata tca atg gag caa gtc aca     1202
 Val Ile Leu Ile Arg Ser Gly Val Asn Ile Ser Met Glu Gln Val Thr
                 305                 310                 315

 gtc gtc gat gcc agc ttc ttc ttg aaa tct acc cag aat gga atc ctg     1250
 Val Val Asp Ala Ser Phe Phe Leu Lys Ser Thr Gln Asn Gly Ile Leu
             320                 325                 330

 aca atg ata cag gac aca caa tgg gtg atc cat tca tgt tgc agc agt     1298
 Thr Met Ile Gln Asp Thr Gln Trp Val Ile His Ser Cys Cys Ser Ser
         335                 340                 345

 cta caa atc cag cac cag gaa ttc tgg gac ctc cac ctc cct cat ttc     1346
 Leu Gln Ile Gln His Gln Glu Phe Trp Asp Leu His Leu Pro His Phe
     350                 355                 360

 atc ttg ggg gac cag cag ttg gac caa gag gaa atc tgg gtg ctg gaa     1394
 Ile Leu Gly Asp Gln Gln Leu Asp Gln Glu Glu Ile Trp Val Leu Glu
 365                 370                 375                 380

 atg gaa acc tgc aag gac cta gac aca tgc aga aag gca gag tgg aaa     1442
 Met Glu Thr Cys Lys Asp Leu Asp Thr Cys Arg Lys Ala Glu Trp Lys
                 385                 390                 395

 ctt agc aga gtt gtt cac atc atg ggt ttt tca acg gag gaa aaa act     1490
 Leu Ser Arg Val Val His Ile Met Gly Phe Ser Thr Glu Glu Lys Thr
             400                 405                 410

 ttg aga tac cag cta tta cag ctg gta gaa cca ttt gga gtc att tca     1538
 Leu Arg Tyr Gln Leu Leu Gln Leu Val Glu Pro Phe Gly Val Ile Ser
         415                 420                 425

 aat cat ctg att cta aat aaa att aat gag gca ttt att gaa atg gca     1586
 Asn His Leu Ile Leu Asn Lys Ile Asn Glu Ala Phe Ile Glu Met Ala
     430                 435                 440

 acc aca gag gat gct cag gcc gca gtg gat tat tac aca acc aca cca     1634
 Thr Thr Glu Asp Ala Gln Ala Ala Val Asp Tyr Tyr Thr Thr Thr Pro
 445                 450                 455                 460

 gcg tta gta ttt ggc aag cca gtg aga gtt cat tta tcc cag aag tat     1682
 Ala Leu Val Phe Gly Lys Pro Val Arg Val His Leu Ser Gln Lys Tyr
                 465                 470                 475

 aaa aga ata aag aaa cct gaa gga aag cca gat cag aag ttt gat caa     1730
 Lys Arg Ile Lys Lys Pro Glu Gly Lys Pro Asp Gln Lys Phe Asp Gln
             480                 485                 490

 aag caa gag ctt gga cgt gtg ata cat ctc agc aat ttg ccg cat tct     1778
 Lys Gln Glu Leu Gly Arg Val Ile His Leu Ser Asn Leu Pro His Ser
         495                 500                 505

 ggc tat tct gat agt gct gtt ctc aag ctt gct gag cct tat ggg aaa     1826
 Gly Tyr Ser Asp Ser Ala Val Leu Lys Leu Ala Glu Pro Tyr Gly Lys
     510                 515                 520

 ata aag aat tac ata ttg atg agg atg aaa agt cag gct ttt att gag     1874
 Ile Lys Asn Tyr Ile Leu Met Arg Met Lys Ser Gln Ala Phe Ile Glu
 525                 530                 535                 540

 atg gag aca aga gaa gat gca atg gca atg gtt gac cat tgt ttg aaa     1922
 Met Glu Thr Arg Glu Asp Ala Met Ala Met Val Asp His Cys Leu Lys
                 545                 550                 555

 aaa gcc ctt tgg ttt cag ggg aga tgt gtg aag gtt gac ctg tct gag     1970
 Lys Ala Leu Trp Phe Gln Gly Arg Cys Val Lys Val Asp Leu Ser Glu
             560                 565                 570

 aaa tgt aaa aaa ctg gtt ctg agg att cca aac aga ggc att gat tta     2018
 Lys Cys Lys Lys Leu Val Leu Arg Ile Pro Asn Arg Gly Ile Asp Leu
         575                 580                 585

 ctg aaa aaa gat aaa tcc cga aaa aga tct tac tct cca gat ggc aaa     2066
 Leu Lys Lys Asp Lys Ser Arg Lys Arg Ser Tyr Ser Pro Asp Gly Lys
     590                 595                 600

 gaa tct cca agt gat aag aaa tcc aaa act gat ggt tcc cag aag act     2114
 Glu Ser Pro Ser Asp Lys Lys Ser Lys Thr Asp Gly Ser Gln Lys Thr
 605                 610                 615                 620

 gag agt tca acc gaa ggt aaa gaa caa gaa gag aag tcc ggt gaa gat     2162
 Glu Ser Ser Thr Glu Gly Lys Glu Gln Glu Glu Lys Ser Gly Glu Asp
                 625                 630                 635

 ggt gag aaa gac aca aag gat gac cag aca gag cag gaa cct aat atg     2210
 Gly Glu Lys Asp Thr Lys Asp Asp Gln Thr Glu Gln Glu Pro Asn Met
             640                 645                 650

 ctt ctt gaa tct gaa gat gag cta ctt gta gat gaa gaa gaa gca gca     2258
 Leu Leu Glu Ser Glu Asp Glu Leu Leu Val Asp Glu Glu Glu Ala Ala
         655                 660                 665

 gca ctg cta gaa agt ggc agt tca gtg gga gac gag acc gat ctt gct     2306
 Ala Leu Leu Glu Ser Gly Ser Ser Val Gly Asp Glu Thr Asp Leu Ala
     670                 675                 680

 aat tta ggt gat gtg gct tct gat ggg aaa aag gaa cca tca gat aaa     2354
 Asn Leu Gly Asp Val Ala Ser Asp Gly Lys Lys Glu Pro Ser Asp Lys
 685                 690                 695                 700

 gct gtg aaa aaa gat gga agt gct tca gca gca gca aag aaa aag ctt     2402
 Ala Val Lys Lys Asp Gly Ser Ala Ser Ala Ala Ala Lys Lys Lys Leu
                 705                 710                 715

 aaa aag cgt cgt ttt cca ggg agt atg gaa ggt ttt gtc act cta gat     2450
 Lys Lys Arg Arg Phe Pro Gly Ser Met Glu Gly Phe Val Thr Leu Asp
             720                 725                 730

 gag gtt ggt gat gag gaa gat tcg gaa ctt cag aaa ctt cgt aaa tcg     2498
 Glu Val Gly Asp Glu Glu Asp Ser Glu Leu Gln Lys Leu Arg Lys Ser
         735                 740                 745

 ggc atg gca ttt aaa tct ggt gac aaa aat gat gat ggt ttg gtt gaa     2546
 Gly Met Ala Phe Lys Ser Gly Asp Lys Asn Asp Asp Gly Leu Val Glu
     750                 755                 760

 att aag gtg gac aag atc gag gaa ctt gat caa gaa aac gaa gca gcg     2594
 Ile Lys Val Asp Lys Ile Glu Glu Leu Asp Gln Glu Asn Glu Ala Ala
 765                 770                 775                 780

 ttg gaa aat gga att aaa aat gag gaa aac aca gaa cca ggt gct gaa     2642
 Leu Glu Asn Gly Ile Lys Asn Glu Glu Asn Thr Glu Pro Gly Ala Glu
                 785                 790                 795

 tct tct gag aac gct gat gat ccc aac aaa gat aca agt gaa aac gca     2690
 Ser Ser Glu Asn Ala Asp Asp Pro Asn Lys Asp Thr Ser Glu Asn Ala
             800                 805                 810

 gat ggt caa agt gat gag aac aag gac gac tat aca atc cca gat gag     2738
 Asp Gly Gln Ser Asp Glu Asn Lys Asp Asp Tyr Thr Ile Pro Asp Glu
         815                 820                 825

 tat aga att gga cca tat cag ccc aat gtt cct gtt ggt ata gac tat     2786
 Tyr Arg Ile Gly Pro Tyr Gln Pro Asn Val Pro Val Gly Ile Asp Tyr
     830                 835                 840

 gtg ata cct aaa aca ggg ttt tac tgt aag ctg tgt tca ctc ttt tat     2834
 Val Ile Pro Lys Thr Gly Phe Tyr Cys Lys Leu Cys Ser Leu Phe Tyr
 845                 850                 855                 860

 aca aat gaa gaa gtt gca aag aat act cat tgc agc agc ctt cct cat     2882
 Thr Asn Glu Glu Val Ala Lys Asn Thr His Cys Ser Ser Leu Pro His
                 865                 870                 875

 tat cag aaa tta aag aaa ttt ctg aat aaa ttg gca gaa gaa cgc aga     2930
 Tyr Gln Lys Leu Lys Lys Phe Leu Asn Lys Leu Ala Glu Glu Arg Arg
             880                 885                 890

 cag aag aag gaa act taa gatgtg caaggagatt taatgatttc aaagaaaata     2984
 Gln Lys Lys Glu Thr 
         895

 atggttcttt gtttttaatg ttaacctttt ttaaatacaa tactgatagt tagaagaaaa   3044

 ctattgtact cttttgtttt agtggagaaa taatagatgt ctgttcatgt gttaagtgtt   3104

 atagcaaaaa aaatacacat atggttaagt taatgaatag tttttgtttt atcagaatgg   3164

 caacagacag aagtactttg tagagattga cttcctaagc tacttaagac aacttgcacc   3224

 actaagaaaa aaatgtagaa ccatttggaa aaatgaaatt tagtagttcc aagtttcaaa   3284

 gaaatgtcaa cattttattc cattcaataa agaacaaaac caatagtgtt tttattactt   3344

 tcatctgaaa cattccatgt tttaatctga gccttgcaga ctttcatttg gagtttgaac   3404

 ccgttttggt tgcatttcat ttttggagaa cttaattaac gtgagattgg caattgaaat   3464

 gcaggtgcca gttttctgtt aatgtcatgc tgttgtttag gtaataagaa atattaagta   3524

 attggcttta gattttgtaa tttttttccc tgagttcctg ctagatttcg tattctagta   3584

 gtcaatgtat tttcagtgaa atgcaaaaat attcccatta tctttgacca gtattaattt   3644

 ttgagatctt actgcttgtc acttgaatcc cgtgattgtc atacatctct ggtataagca   3704

 acatttgatt tttgaagtgt gtagaccatc tcttcatatt ttcaagatgt aattttacat   3764

 ttctgcattt ttaaaacagt ttggccataa tcctagatgc acgcttctaa ttcatgtacc   3824

 tgcacatgtg acctttgtga acagaaattt gcatgtataa tttgtgttta cttgtaactt   3884

 tctggttata tactgcttat atctgtggat tcaagttact gaagtgaata ccaataaaaa   3944

 gaaaacccta ggccatgtta attggttata catgtttgga atgttaacca acgt         3998




      <210> 429
      <211> 1634
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1217)..(1516)

      <400> 429
 ccttgaccct ctgtctggtt tcgtctcctg aaattcattt gtggttttaa ataagacaat     60

 attatcacat tacccaccaa aaaataacta gtataacaat tcacctggat gatttgcaga    120

 ctatcatttc tgtgttctcc ccatcaaata caatgaaaag ctgatctaaa gatatttaca    180

 actggggtgg aatacacatt tttttgaggc tagttatatc atggagaatc acacttaatg    240

 agatctgact ccatcactgt accaaagaag tcaaggagtc agacgtaaac agctgagcac    300

 caaaaggcca ttggctccac atatacatgt ggcaatgaga ctgcaaaacc caagctaatc    360

 agaggtccat gaaccaccaa gggtgactta tagagctggt aatttccacc aacaaaagct    420

 acttattaat ctaatctttt tgttatgaac aaatgcagag gcagtatttt gcccaaaatt    480

 gaatgaagaa gaaagctttc aaactctatc gaagactgtt aaataatcta gatctattct    540

 tcctacgtcc ctttcgttcc cacccttaaa aaagagagtt gctacctggg agtcactttt    600

 aacaagacaa taccaaaaaa agcaaaaaag gaactaggtt agtcaataca cactgtgagc    660

 tccaacacat actgtaccca tctgcattct tcaagacctc agctgcagaa ttttatgccc    720

 gctgttgaaa agtgttaaag gaaaagtttt cttgcccaca cctgcagtaa ggaagtcggg    780

 ggaatgatac ataaaagtaa aggtaaagtg gtatgtgaca aattttaaag ctagtctgtg    840

 tatacaacac agagctgtgc aacgctagag gaggaatata ttttaggatt tgcaagcatc    900

 caggattaat gtagtgtctt tttattgaaa atgttttctt tttaaactac acttttaaag    960

 ttacttgtga aaaaaagcaa acactttttt gttataacag cttagaaatt ggttgtgact   1020

 cacggctcga tgaacatgag gctttctgca actcccttgc agatttgatg taggcaggca   1080

 aagatacact ggacctaacg actgtcaagc gctggctaca cagaggctct cctgtgtgct   1140

 ggggggaagg gggcagctgg aaaagtactt ggcagaaacc cacgttagaa aagctcagtt   1200

 tacggttccc cttgca    atg gta cag aac cag agc ggg cca ggt ttt cga    1249
                      Met Val Gln Asn Gln Ser Gly Pro Gly Phe Arg
                        1               5                  10

 ggc cca tcc ggc tcc ctc ggg tgt agc ttc ttc cca agg agc ctc gga     1297
 Gly Pro Ser Gly Ser Leu Gly Cys Ser Phe Phe Pro Arg Ser Leu Gly
              15                  20                  25

 aga gtt ctg cca ccc ggc tgc cag cga cct gga gcc cac gct gat tcc     1345
 Arg Val Leu Pro Pro Gly Cys Gln Arg Pro Gly Ala His Ala Asp Ser
          30                  35                  40

 agc cct ccg ccg act cca cag ttc gcg gag ggg cac gga gcc gcg gcg     1393
 Ser Pro Pro Pro Thr Pro Gln Phe Ala Glu Gly His Gly Ala Ala Ala
      45                  50                  55

 ccc gcc ggg gag gaa gta gca gga cgg tac ata gga agg agg ctg aag     1441
 Pro Ala Gly Glu Glu Val Ala Gly Arg Tyr Ile Gly Arg Arg Leu Lys
  60                  65                  70                  75

 ccc cat cca tgg cgc aga ctc cga gag agg agc ccg acc tgg acc cac     1489
 Pro His Pro Trp Arg Arg Leu Arg Glu Arg Ser Pro Thr Trp Thr His
                  80                  85                  90

 ggc cgc ctc aga gac gca ccg gct tag acaaa ggcccggcgc ctgcggtcgg     1541
 Gly Arg Leu Arg Asp Ala Pro Ala 
              95

 agcgcggggg aggaggagcg atgccccgcg caggcgcagg cgcagacgat cgcgacgaga   1601

 tcgtcgaccc ggaaattccg gagcggtacc gca                                1634




      <210> 430
      <211> 1365
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (563)..(754)

      <400> 430
 ggctaggtag cgaggctggg tgtccccacc gcgcgggatt gacttctaaa gactcttggt     60

 atgtgaggaa gaaacctgga agaggaagag gaaagcaaag gagtcaggat ggctcttcct    120

 cagggtctat tgacattcag ggatgtggcc atagaattct ctcaggagga gtggaaatgc    180

 ctggaccctg ctcagaggac tctatacagg gacgtgatgc tggagaatta taggaacctg    240

 gtctccctgg agttgtcagg ggagtgtcca ttggcagcac ctgcctcctg agtgtctccc    300

 aggccatcac catcagcccc aggagctcag gtgggcagag cttaaaggga acgcccccaa    360

 gcacgctggc tcctgtgtgt tcctcagctg gctcctccct ggtcaatatc attgttctca    420

 tgcacgtgac cggcaagtgg agcaacaaaa ataccacaaa gacaaaagat ctgggatact    480

 gttctgctgc tgatcacgag ggcaccagag agtcgctgac gcggcactgc tgtccttccc    540

 tgatgtgatc tgcctggggc tc atg ctc tgg ggc agc agc tcc atc gtt tgc     592
                          Met Leu Trp Gly Ser Ser Ser Ile Val Cys
                            1               5                  10

 atc ctg cac agg cac aag cgg cgg gtc cag cac att cat agg acc agc      640
 Ile Leu His Arg His Lys Arg Arg Val Gln His Ile His Arg Thr Ser
                  15                  20                  25

 gtc tcc ccc aca tcc tcc cct gag tcc gga gct acc aaa acc atc ctc      688
 Val Ser Pro Thr Ser Ser Pro Glu Ser Gly Ala Thr Lys Thr Ile Leu
              30                  35                  40

 ctg gtg agc acg ttt gtg tcc ttt tac act ctc tct tca cct ttc aag      736
 Leu Val Ser Thr Phe Val Ser Phe Tyr Thr Leu Ser Ser Pro Phe Lys
          45                  50                  55

 ttt gtt tgg ctc ttt tga ataatc ccagtcagct ggtggtgaac atctctgcaa      790
 Phe Val Trp Leu Phe 
      60

 tgatcagtgc aggtttccca actgtcagcc cctttcttct catgagtgga gactccagtg    850

 tatccaagct tggctttgct gtggtgaata acacaaaaac ccctgatctt ttcagaaata    910

 tgtgaaattg gatatgtctg tacaatgttt atgtttcttc attgatctct atagacccca    970

 taaacacggt tatgaaacga ggctgttagt gctgtgcttg ccagcaaggg gccaatgttt   1030

 tattctgtaa cctcctgatg ccccctttca cccaacgact gggggcagtc tgtggacaag   1090

 tggaatcagg ttagacgggt tgggaggaag atatggaacg taaacgattt agaaagtccg   1150

 gtggccaata tcctactcat ttctgggttc ctgggcgatg gggatgtgcg agatgcaagt   1210

 ctgtggattt tgtggactaa aaattttgtg gtggccgatt tggttgcaat ctaaagggca   1270

 ctgtgtgaga ggaaccaagg cgggggcgcc tcacgggggg gggggtaggc gcagggtctt   1330

 taaaaaaagg gggcttgggg ggtttttcgg cggtc                              1365




      <210> 431
      <211> 1627
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (161)..(1498)

      <400> 431
 ggccaaggag ggcactggga gctccgttcc gggagagctg tctaaggacg cggaaccggg     60

 tggggaggcc agggaggact gtttcttttt ccaaaagagg agctcaaaag agaaagttca    120

 tctagaaatc tcaaagccat gtctcaggat gaactagagt  atg ccc tta cag gga     175
                                              Met Pro Leu Gln Gly
                                                1               5

 tca gtg tca ttc aag gat gtg act gtg gac ttc acc cag gag gag tgg      223
 Ser Val Ser Phe Lys Asp Val Thr Val Asp Phe Thr Gln Glu Glu Trp
                  10                  15                  20

 cag caa cta gac cct gct cag aag gcg ctt tac agg gat gtg atg ttg      271
 Gln Gln Leu Asp Pro Ala Gln Lys Ala Leu Tyr Arg Asp Val Met Leu
              25                  30                  35

 gaa aac tat tgc cac ttc gta tct gtg ggg ttt cac atg gct aag cct      319
 Glu Asn Tyr Cys His Phe Val Ser Val Gly Phe His Met Ala Lys Pro
          40                  45                  50

 gat atg atc cgc aag ttg gaa caa gga gaa gag cta tgg aca cag aga      367
 Asp Met Ile Arg Lys Leu Glu Gln Gly Glu Glu Leu Trp Thr Gln Arg
      55                  60                  65

 att ttt cca agt tac agc tac cta gtg aat ctc cat aaa caa aca gaa      415
 Ile Phe Pro Ser Tyr Ser Tyr Leu Val Asn Leu His Lys Gln Thr Glu
  70                  75                  80                  85

 aga gtt ctc agt ggt aaa cag gag ctt att cag cat cag aag gtt caa      463
 Arg Val Leu Ser Gly Lys Gln Glu Leu Ile Gln His Gln Lys Val Gln
                  90                  95                 100

 gct cca gag caa cca ttt gac cat aat gaa tgt gaa aaa tcc ttc ctg      511
 Ala Pro Glu Gln Pro Phe Asp His Asn Glu Cys Glu Lys Ser Phe Leu
             105                 110                 115

 atg aaa gga atg cta ttt aca cat act aga gct cac aga gga gaa aga      559
 Met Lys Gly Met Leu Phe Thr His Thr Arg Ala His Arg Gly Glu Arg
         120                 125                 130

 acc ttt gaa tac aat aaa gat gga att gcc ttc ata gaa aag tca agc      607
 Thr Phe Glu Tyr Asn Lys Asp Gly Ile Ala Phe Ile Glu Lys Ser Ser
     135                 140                 145

 ctc agt gtc cat cca agt aat ctt atg gaa aag aag ccc tct gcc tac      655
 Leu Ser Val His Pro Ser Asn Leu Met Glu Lys Lys Pro Ser Ala Tyr
 150                 155                 160                 165

 aac aaa tat ggg aaa ttc ctc tgc aga aag cct gtt ttt att atg cct      703
 Asn Lys Tyr Gly Lys Phe Leu Cys Arg Lys Pro Val Phe Ile Met Pro
                 170                 175                 180

 cag aga cct caa aca gaa gag aaa ccc ttt cac tgt cct tac tgt ggg      751
 Gln Arg Pro Gln Thr Glu Glu Lys Pro Phe His Cys Pro Tyr Cys Gly
             185                 190                 195

 aat aac ttt aga agg aag tca tac ctc att gaa cat cag cga att cac      799
 Asn Asn Phe Arg Arg Lys Ser Tyr Leu Ile Glu His Gln Arg Ile His
         200                 205                 210

 aca ggt gaa aaa cct tat gtt tgc aat caa tgt gga aag gcc ttc cgt      847
 Thr Gly Glu Lys Pro Tyr Val Cys Asn Gln Cys Gly Lys Ala Phe Arg
     215                 220                 225

 cag aag aca gcc ctc acc ctt cat gag aaa aca cat ata gag ggg aaa      895
 Gln Lys Thr Ala Leu Thr Leu His Glu Lys Thr His Ile Glu Gly Lys
 230                 235                 240                 245

 ccc ttt att tgt atc gat tgt ggg aag tcc ttc cgc cag aag gcc acc      943
 Pro Phe Ile Cys Ile Asp Cys Gly Lys Ser Phe Arg Gln Lys Ala Thr
                 250                 255                 260

 ctc act aga cat cac aaa aca cat acg ggg gag aaa gcc tat gaa tgt      991
 Leu Thr Arg His His Lys Thr His Thr Gly Glu Lys Ala Tyr Glu Cys
             265                 270                 275

 cct cag tgt gga agt gcc ttt agg aag aag tca tac ctc att gat cac     1039
 Pro Gln Cys Gly Ser Ala Phe Arg Lys Lys Ser Tyr Leu Ile Asp His
         280                 285                 290

 cag aga act cac aca gga gag aaa ccg tat cag tgt aat gag tgt ggg     1087
 Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Gln Cys Asn Glu Cys Gly
     295                 300                 305

 aag gca ttt atc cag aag aca acc ctc act gtt cat cag aga act cac     1135
 Lys Ala Phe Ile Gln Lys Thr Thr Leu Thr Val His Gln Arg Thr His
 310                 315                 320                 325

 aca gga gag aaa ccc tat att tgc aat gaa tgt ggg aag tcc ttc tgc     1183
 Thr Gly Glu Lys Pro Tyr Ile Cys Asn Glu Cys Gly Lys Ser Phe Cys
                 330                 335                 340

 caa aag aca acc ctc act ctc cac cag aga att cac acg ggg gaa aaa     1231
 Gln Lys Thr Thr Leu Thr Leu His Gln Arg Ile His Thr Gly Glu Lys
             345                 350                 355

 ccc tat att tgt aat gaa tgt ggg aag tcc ttc cgc cag aag gca atc     1279
 Pro Tyr Ile Cys Asn Glu Cys Gly Lys Ser Phe Arg Gln Lys Ala Ile
         360                 365                 370

 ctc act gtt cat cac aga ata cat aca gga gaa aaa tcc aat ggg tgt     1327
 Leu Thr Val His His Arg Ile His Thr Gly Glu Lys Ser Asn Gly Cys
     375                 380                 385

 cct cag tgt ggg aaa gcc ttc agt agg aaa tca aac ctc att cgc cat     1375
 Pro Gln Cys Gly Lys Ala Phe Ser Arg Lys Ser Asn Leu Ile Arg His
 390                 395                 400                 405

 cag aaa act cac aca ggc gag aaa cca tat gaa tgt aaa cag tgt ggg     1423
 Gln Lys Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly
                 410                 415                 420

 aag ttc ttc agt tgt aag tca aac ctc att gtc cat cag aaa act cac     1471
 Lys Phe Phe Ser Cys Lys Ser Asn Leu Ile Val His Gln Lys Thr His
             425                 430                 435

 aag gta gaa acc acg gga att cag taa gtaat gtggcttttt ttgtaaaaaa     1523
 Lys Val Glu Thr Thr Gly Ile Gln 
         440                 445

 atgttaagtc atagtaaacc ctgtagatga tgttgcttgc aagcgtaata tccaacagtt   1583

 taaggtacta taccacatgg tgacctactg tttgccagcc tgta                    1627




      <210> 432
      <211> 4324
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2127)..(2318)

      <220>
      <221> misc_feature
      <222> (1)...(4324)
      <223> n = a,t,c or g

      <400> 432
 tttcccagtt ccctttgctc atgcttactt agaggaagaa agaaaggggg gtacctcttc     60

 caagtacctt ctaaatgaaa cactcaagag agtgctactc aggaaacttt gcttggatcc    120

 taaaatggac tggtcttggg tgtgtaaccc cggtgaagtt atagcctccc caaattgagg    180

 tgacagaagg aagacaagag gtgtaagctg gagagggaag ggaagaaatc agtggctttg    240

 gccagcctct gtgccaccca gtacgacaga ggagtgggaa ctggccctct ggggctctgc    300

 ttggccatag gcactgcaca ttgtgccacc tgctcatcac ctcctctagt ctcacactga    360

 gcatcggagt acctgttgtg cagacaggaa aactgaggag ctctgagagg ctgagcatgg    420

 agctcacccc atgccatagg gtgtgggaag agggcacagg aggcctcatc catgggggaa    480

 agggttgagg atggacatgg gtggggagag ggcatagaca tcccttccta atctctgttc    540

 ccaccacatt tcataggaga tgagttagga gatgacagct aactctctta aggacatttt    600

 gaccccagtt tatgttgggg atggaccaga aaggaaaatg tctagagata ggaaggtaaa    660

 tcaactctgc cagcccctac catcaggtct gggccacccc aaacttgggc tgcctccctt    720

 agacataggt tagagtgaga gacccagctg tttctcccga agcctcgtct tcatgcccca    780

 gacacctgat tgccccaatc aggtgtcaga cttgcttgct cttcaaggtc cccctgagct    840

 gccaagtgtt ttcattgtaa acagacacat cgccatgttt cagggcttca acggcgttgt    900

 attttggact ttgaccgtat tttttttctc ttaacctact gagactcttc cttaagaaca    960

 ggatctatag ctttaaaatg tcttcttcta tgggaaattt cctgccaagc cagggcacta   1020

 aattctttca tcattagagc tttcctgaag tccggccata tactgagtac ctgctctgag   1080

 ttctgggcag cttacaatat cttaaacaga ttttcagaaa aataatgcaa ctatattttc   1140

 tagtgtcaac tgtatgcaaa cagtgtggta aatacctttt aattagtcct ccacccacct   1200

 ggagtacagg gggtgcgttt attattctga tttcactgat gaggaaatgg gctcagaaag   1260

 gttaagtccc ttcctgaaat ctcacagcca ggagaagcta ggatgattta aaacaaagtt   1320

 tggagaggca ctgggcatag accctggctg tacagcctct aacatgcggc actgcatctt   1380

 ggcagtctct atgcctgtct gtgatgtgtg tgtgcacgtg taactnnnnn nnnnnnnnnn   1440

 nnnnnnnnnn nnnnnnnnnn ncacacatct cagagcctaa gaaataggac taagcccaga   1500

 actcctagaa tcacctataa atgctaggca tagatggaaa ttattgtgtt ccaccagaag   1560

 cacagctcca aactatacct aaaaaatatt tctgcacttc ccagagacct ggacttcaaa   1620

 ctttcccagt ggagcctgat tatagaactt gagggtccta tctcaggatg aaggggagag   1680

 gccctggctt cacgggaagg tattccagca ttgttctgct tcacccttga ctgcgttgtc   1740

 tggcagtttc tgtgtgctgc caggatatta tatggaactg gagaagttgg agtcaggtct   1800

 ctgaagctag agtttcacta attagatgcc tctgtacatg agaactatta ctgtctgcag   1860

 gtccatatag ctaagctgcc aggaaaaaca cattatcttc caaaactttc agagcatgtg   1920

 cagaaccctt tcttagcgtt ttcttctcag cattttctct gcctcccaga ggctggcagc   1980

 cagtgacact gcagagttca gcatgttcta accatgcacg cagggcaggg gctgccttgg   2040

 ccctcctcag gctttcgttg ggagagcagg cagtggtgga gcccttctgg gtgcagtcct   2100

 ctggggttgc tctttggaac tcatgt atg agt ttg act cca caa ggc ttg gca    2153
                              Met Ser Leu Thr Pro Gln Gly Leu Ala
                                1               5

 tgg ata cca aaa cag ttg caa caa att agt tct gaa cct gga aca gag     2201
 Trp Ile Pro Lys Gln Leu Gln Gln Ile Ser Ser Glu Pro Gly Thr Glu
  10                  15                  20                  25

 aat tca gtg ctt ctg tta ctc agg aag gag gtg ttc aga atg ccc cgt     2249
 Asn Ser Val Leu Leu Leu Leu Arg Lys Glu Val Phe Arg Met Pro Arg
                  30                  35                  40

 gca gag cag cca gtc att act ctg ttt gtt ctc acc tgg gtg cgc acc     2297
 Ala Glu Gln Pro Val Ile Thr Leu Phe Val Leu Thr Trp Val Arg Thr
              45                  50                  55

 ctc atg atg cag tgg ctg tag ca ccttcatgcc aggtgctgag agaatgggaa     2350
 Leu Met Met Gln Trp Leu 
          60

 attcttcctc cccattgacc tgagtcccag agacttaggg acacagactt caggtgaggc   2410

 tgcggacctc agaagcagtg gataatagat tggggcatta aaagcttttg aggcaggggg   2470

 ctcatgtttt gactgcaggg agttatgctg agcaaagaga tgtgtttttc aaaaccaggg   2530

 ttcaaaacca gtgtccacgc tggagtaagt ggagcatgct tctctgtgtt ctctgaatga   2590

 tcttgcactc ctcttaagca aaggagtacc atgaccatag tcagtgggat cccacaaatg   2650

 ttcttaaatg ggtaaggctt taagtagcca gagagtatcc agcctaccat tggcttctcc   2710

 acatcctaaa acctgagaca gccttggtat atgctttata aatgtttctt ttcttgttgt   2770

 ttaagtaatt aaagtgttta aaatgtcttc attagatgtg acgattgttt aatgagtttg   2830

 cctctgacgt gtggctccat gggagatagg caaagtaatt aagaagttac cagaaattgg   2890

 tcggctgggg aaatgcaaaa gttagcattt cagtagtgaa tttctcctgg aacaaatgag   2950

 caatttttcc tctttctctt aagtagtata cccttttctc acttagtaat ttaatggtat   3010

 ataaagacat gtgtataagt gagtgcatac atatgaggta tgactatagg gttgtttgtg   3070

 ggaatttctt ttcctaacat acagaagatc aaagtgttca tctcaccccg ccctccttaa   3130

 aaggtgtctt ttgggagact atgtgctcat tgactatagt gctgccaagt aaaaatatct   3190

 tgggaactct tctactagaa tggccttcag ggcttggcat gttcctttgg tttaccctta   3250

 gagatgagaa atcctcctcc tttgaggatg gatttaagtt ctggaaataa tctcaagtgc   3310

 ttgatagcac agttggatga aaaaagatgg caattaaggt aagttacacc atttttgttt   3370

 ctaaaaaaat ccctaagaaa tttcttggaa tgagtctttg gcctcagagc ctctcaaagt   3430

 gtccacttca aggggggatc atcctcatta gcacacagat ttttaaaaat caattctctt   3490

 gccatgcctc ctatgtgttc acatctctgc atacactaca gatataagtg cataatcatt   3550

 catataaaca tctggtaggt attctgtaaa actgtgttta ctttagtgca tgttattgtc   3610

 atgttatgat gtgactgggg tgtttctttg tcatgaaact ttgcttcttc acagaattag   3670

 aatactgctc tctctatatt gaactacata tacagcgttt tcttgtatca gcccccaaag   3730

 tctggatgcc cggtgttgtg tttacatgtg attgtgccta ggagtctgtt cacatagaga   3790

 cacctgtaag tatttattac aaaacggaat gtaagcaaat atatccacat tggttttatt   3850

 tgaatcaagg tgtttttttg ttttttgttt tttttccttt tgaggaggaa cagggagcct   3910

 cctcctccat gagcacttac agaattgtgt aaaattctgt gaaacagtgg taagcatggg   3970

 cacccgattt cagctgtcct gctgccgctg ccctccaacc tgctctgtgt gtgtgtgtcg   4030

 ctgtgcttgg tggcagtgtg ccgtgctcgt gccggctctt cccagcagac tggtatctgg   4090

 ctgtaacgtt tgacgtcttc atattgccag tctgtattga ggggtgatgt acatggccat   4150

 acagccaaat gggtctgtgt accagtgtgg ggattccaag aacactgcct gtcccccaca   4210

 gcaaatattg atgctgttgg tcagccaaag attttcctct cctttgctgc ttaaacttgt   4270

 gccttaatat tgtacataat aaatggataa aatggcaaaa tgaaaaaaaa aaaa         4324




      <210> 433
      <211> 2263
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (5)..(1714)

      <400> 433
 ggcg atg gca cct cca cag cct ctt tcc agg atc tgc ctc tgt gac cac      49
      Met Ala Pro Pro Gln Pro Leu Ser Arg Ile Cys Leu Cys Asp His
        1               5                  10                  15

 acg ggg ttg tcc tgg gcc cga gcc ttt tcc cac agc gcc gcc ttg tgg       97
 Thr Gly Leu Ser Trp Ala Arg Ala Phe Ser His Ser Ala Ala Leu Trp
                  20                  25                  30

 aca cct gtg cag gag cca gca gcc cgc gga ggc tac ctg ctc cgg gtg      145
 Thr Pro Val Gln Glu Pro Ala Ala Arg Gly Gly Tyr Leu Leu Arg Val
              35                  40                  45

 cac atc ctg cta ggt gtc ccc aac tcc tgc cca gcc agt cca cgc ggt      193
 His Ile Leu Leu Gly Val Pro Asn Ser Cys Pro Ala Ser Pro Arg Gly
          50                  55                  60

 gcc ggc tcc tcc agt tac cgc ttt gtg cag aac gtg acc tcg gac ctg      241
 Ala Gly Ser Ser Ser Tyr Arg Phe Val Gln Asn Val Thr Ser Asp Leu
      65                  70                  75

 cag ctg gca gca gag ttt gca gca aag gcc gcg tcg gag cag cag gca      289
 Gln Leu Ala Ala Glu Phe Ala Ala Lys Ala Ala Ser Glu Gln Gln Ala
  80                  85                  90                  95

 gac acg tct gga gga gac agc ccc aag gat gag tca aag ccg ccg ttc      337
 Asp Thr Ser Gly Gly Asp Ser Pro Lys Asp Glu Ser Lys Pro Pro Phe
                 100                 105                 110

 tcc tac gcg cag ctg atc gtg cag gcc atc tcc tcc gcc cag gac cgg      385
 Ser Tyr Ala Gln Leu Ile Val Gln Ala Ile Ser Ser Ala Gln Asp Arg
             115                 120                 125

 cag ctg acc ctg agc ggg atc tac gcc cac atc acc aag cat tac ccc      433
 Gln Leu Thr Leu Ser Gly Ile Tyr Ala His Ile Thr Lys His Tyr Pro
         130                 135                 140

 tac tac cgg acg gcc gac aaa ggc tgg cag aat tct atc cgg cac aac      481
 Tyr Tyr Arg Thr Ala Asp Lys Gly Trp Gln Asn Ser Ile Arg His Asn
     145                 150                 155

 ctc tct ttg aac cgt tac ttt atc aaa gtc cca cgt tcc cag gag gag      529
 Leu Ser Leu Asn Arg Tyr Phe Ile Lys Val Pro Arg Ser Gln Glu Glu
 160                 165                 170                 175

 cct ggg aag ggg tcc ttt tgg cga ata gac cct gcc tct gaa gcc aag      577
 Pro Gly Lys Gly Ser Phe Trp Arg Ile Asp Pro Ala Ser Glu Ala Lys
                 180                 185                 190

 ctc gtg gaa cag gca ttc cgg aaa cgg agg cag agg ggt gtc tcc tgc      625
 Leu Val Glu Gln Ala Phe Arg Lys Arg Arg Gln Arg Gly Val Ser Cys
             195                 200                 205

 ttc cgc acc ccc ttc ggg cct ctg tcc tca agg agc gct cca gct tcg      673
 Phe Arg Thr Pro Phe Gly Pro Leu Ser Ser Arg Ser Ala Pro Ala Ser
         210                 215                 220

 ccc aca cac ccc ggg ctg atg tcc cct cgc tcc ggc ggc ctg cag acc      721
 Pro Thr His Pro Gly Leu Met Ser Pro Arg Ser Gly Gly Leu Gln Thr
     225                 230                 235

 cca gag tgc ctg tct cgg gag ggc tcc ccc att cca cac gac cct gag      769
 Pro Glu Cys Leu Ser Arg Glu Gly Ser Pro Ile Pro His Asp Pro Glu
 240                 245                 250                 255

 ttt ggg tcc aag tta gct tct gtc cca gag tac cgg tat tcc caa agc      817
 Phe Gly Ser Lys Leu Ala Ser Val Pro Glu Tyr Arg Tyr Ser Gln Ser
                 260                 265                 270

 gca ccc ggc tcc ccc gtc agc gcc cag cca gtg atc atg gcc gtg cct      865
 Ala Pro Gly Ser Pro Val Ser Ala Gln Pro Val Ile Met Ala Val Pro
             275                 280                 285

 ccc cga ccg tcc agc ctc gtg gcc aag ccc gtg gcc tac atg ccc gcc      913
 Pro Arg Pro Ser Ser Leu Val Ala Lys Pro Val Ala Tyr Met Pro Ala
         290                 295                 300

 tcc atc gta acc tca cag cag ccc gcg ggc cac gcc atc cac gtc gtg      961
 Ser Ile Val Thr Ser Gln Gln Pro Ala Gly His Ala Ile His Val Val
     305                 310                 315

 cag cag gcc ccc acc gtc acc atg gtc agg gtg gtc acc aca tct gcc     1009
 Gln Gln Ala Pro Thr Val Thr Met Val Arg Val Val Thr Thr Ser Ala
 320                 325                 330                 335

 aac tcg gcc aac gga tac atc ctc acc agc cag ggc gcg gcg ggg ggc     1057
 Asn Ser Ala Asn Gly Tyr Ile Leu Thr Ser Gln Gly Ala Ala Gly Gly
                 340                 345                 350

 tcc cat gat gcg gcg ggc gca gcc gtg ctg gac ctg ggc agc gag gcc     1105
 Ser His Asp Ala Ala Gly Ala Ala Val Leu Asp Leu Gly Ser Glu Ala
             355                 360                 365

 aga ggc ctg gag gag aaa ccc acc att gcg ttt gcc aca atc ccc gcg     1153
 Arg Gly Leu Glu Glu Lys Pro Thr Ile Ala Phe Ala Thr Ile Pro Ala
         370                 375                 380

 gct ggt gga gtc atc cag acg gtg gcc agc cag atg gcc ccc ggg gtc     1201
 Ala Gly Gly Val Ile Gln Thr Val Ala Ser Gln Met Ala Pro Gly Val
     385                 390                 395

 ccc gga cac acg gtc acc atc ctg cag ccc gcc aca ccc gtg acc ctc     1249
 Pro Gly His Thr Val Thr Ile Leu Gln Pro Ala Thr Pro Val Thr Leu
 400                 405                 410                 415

 ggg cag cac cac ctt cca gtc cgg gcc gtg acc cag aac gga aag cat     1297
 Gly Gln His His Leu Pro Val Arg Ala Val Thr Gln Asn Gly Lys His
                 420                 425                 430

 gcg gtt ccc acg aac agt tta gcc ggc aac gct tac gcc ctc acc agc     1345
 Ala Val Pro Thr Asn Ser Leu Ala Gly Asn Ala Tyr Ala Leu Thr Ser
             435                 440                 445

 cct ttg cag ctc ctt gcg acc caa gcg agt tca tcc gcg ccg gtg gtg     1393
 Pro Leu Gln Leu Leu Ala Thr Gln Ala Ser Ser Ser Ala Pro Val Val
         450                 455                 460

 gtc acc cgg gtg tgc gag gtg ggg ccc aag gag cca gca gca gcc gtc     1441
 Val Thr Arg Val Cys Glu Val Gly Pro Lys Glu Pro Ala Ala Ala Val
     465                 470                 475

 gcg gcc acg gcc acc acc acc cca gcc act gcc acc acc gcc tct gcc     1489
 Ala Ala Thr Ala Thr Thr Thr Pro Ala Thr Ala Thr Thr Ala Ser Ala
 480                 485                 490                 495

 tcc gcc tct tcc act gga gag ccc gag gtc aaa agg tcc cgg gtg gag     1537
 Ser Ala Ser Ser Thr Gly Glu Pro Glu Val Lys Arg Ser Arg Val Glu
                 500                 505                 510

 gag ccc agt ggg gct gtg acc aca ccg gct gga gtg atc gca gct gcc     1585
 Glu Pro Ser Gly Ala Val Thr Thr Pro Ala Gly Val Ile Ala Ala Ala
             515                 520                 525

 ggc ccc cag ggg cca ggc acc ggg gag tca gct gtc agt ttt gct ggc     1633
 Gly Pro Gln Gly Pro Gly Thr Gly Glu Ser Ala Val Ser Phe Ala Gly
         530                 535                 540

 cgc tcc ggc gct ggc tct cct ggt ccg gga cca caa cga gaa aca gcg     1681
 Arg Ser Gly Ala Gly Ser Pro Gly Pro Gly Pro Gln Arg Glu Thr Ala
     545                 550                 555

 aca gat tcg acg cag agc tcc gga agt gcc tga ggagcagt ggttcttgga     1732
 Thr Asp Ser Thr Gln Ser Ser Gly Ser Ala 
 560                 565

 aatcgcccgt cctccgcatc acagcctctt caccagcaaa gcagcactat gcccaggccc   1792

 tgtcgagaga gctgcagagg gacccaggtg cctggaggca atttgaggga ggtggctgga   1852

 caggtgtctc cctgaagaag aagggagaac acgtggcaaa gtgattccga ggcagtgcgg   1912

 gaggacacac gtgctgtgca gtggagtggg gtcgcccgtg gcccccatca gagtccccgt   1972

 cccccaggac aagtgcagaa cctctgtggg ccccctcctt ccacctagat agagaaaacc   2032

 ccttgttcgg tttccttccc gtgtcccgtt gtttttctaa gccccccgaa ttgagtcgtt   2092

 tctatggcac taacctttcc atgggaaata agctctttgt ggaagtccgt acctgttgcc   2152

 ctgggtgagg tttcagagaa acgggggcag gatgaacaca gccggctgtc ctgggtgcag   2212

 ttacgtccgt ggagggtgag agattgcgcc ccgttccaca cttgtgtcgc t            2263




      <210> 434
      <211> 775
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(735)

      <400> 434
  atg gaa tac tac aaa cgc aga ata aat att tca tta gga aca aat tat      48
  Met Glu Tyr Tyr Lys Arg Arg Ile Asn Ile Ser Leu Gly Thr Asn Tyr
    1               5                  10                  15

 caa ggg aca tat gcc cac ctc tca ggg gat gac gcc aag gca ctg gca       96
 Gln Gly Thr Tyr Ala His Leu Ser Gly Asp Asp Ala Lys Ala Leu Ala
              20                  25                  30

 ttc cag agt ttc gta caa agt cag aaa gat gtg cgg cca agg agg gct      144
 Phe Gln Ser Phe Val Gln Ser Gln Lys Asp Val Arg Pro Arg Arg Ala
          35                  40                  45

 aat gcg agt tta ttt gga ttg tcc agt tta atc gtc aaa aca ccc ctg      192
 Asn Ala Ser Leu Phe Gly Leu Ser Ser Leu Ile Val Lys Thr Pro Leu
      50                  55                  60

 aca tac ggg tcc ttc ctg gca ggt gag gaa act gag gtt cga gta ggg      240
 Thr Tyr Gly Ser Phe Leu Ala Gly Glu Glu Thr Glu Val Arg Val Gly
  65                  70                  75                  80

 cat cca gag ctg ggg cgg gca gtt ggc agc ctg cag ccc ctg agg tcc      288
 His Pro Glu Leu Gly Arg Ala Val Gly Ser Leu Gln Pro Leu Arg Ser
                  85                  90                  95

 cgg cag atc ttc cct ggc ccc cag cca ggc acg ctg cac act cca gct      336
 Arg Gln Ile Phe Pro Gly Pro Gln Pro Gly Thr Leu His Thr Pro Ala
             100                 105                 110

 cat tca cct gcc aat cac ctg tcc agg act cag gcc ggc ggg gcc tcc      384
 His Ser Pro Ala Asn His Leu Ser Arg Thr Gln Ala Gly Gly Ala Ser
         115                 120                 125

 cgt cct ccc gcc agc ccc ctt gct cat cgc tgg ggc ctc cct gcg agg      432
 Arg Pro Pro Ala Ser Pro Leu Ala His Arg Trp Gly Leu Pro Ala Arg
     130                 135                 140

 ctg tca gcg gcc gag gtg ggg gcc ctt gcc ggg gtg agg agc cga tcg      480
 Leu Ser Ala Ala Glu Val Gly Ala Leu Ala Gly Val Arg Ser Arg Ser
 145                 150                 155                 160

 tcc acc gga tca ggc ccc ctg cag cag ccc gcc tgg agc ccg agc atg      528
 Ser Thr Gly Ser Gly Pro Leu Gln Gln Pro Ala Trp Ser Pro Ser Met
                 165                 170                 175

 gcc ggg cgg gga agg ggc ggc ggc acc gga att gct ccg ccc agc tta      576
 Ala Gly Arg Gly Arg Gly Gly Gly Thr Gly Ile Ala Pro Pro Ser Leu
             180                 185                 190

 ggc cgg ggc cgt ggc tcc tgt gca aga tgg gcc tgt gca ccc tcc agc      624
 Gly Arg Gly Arg Gly Ser Cys Ala Arg Trp Ala Cys Ala Pro Ser Ser
         195                 200                 205

 ccc tgg gcc ctc ctc gaa aat cct cca cat cct gcg gga cct gga ccg      672
 Pro Trp Ala Leu Leu Glu Asn Pro Pro His Pro Ala Gly Pro Gly Pro
     210                 215                 220

 cca gcg gcc tcc caa gcc tgg gcc att tgc ccc gtc gcc tcc gcc tgg      720
 Pro Ala Ala Ser Gln Ala Trp Ala Ile Cys Pro Val Ala Ser Ala Trp
 225                 230                 235                 240

 cat tcg act tct tag aaccgcgggc acgagggcag cgtgggggca gtggtggctg      775
 His Ser Thr Ser 






      <210> 435
      <211> 1765
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (29)..(1765)

      <400> 435
 cggaagcaga ttacgtggag tgacggtc   atg ctg cgg cgt gga cac ttg gca      52
                                  Met Leu Arg Arg Gly His Leu Ala
                                    1               5

 ttc agg gac atg gcc ata gaa ttc cct cag gag gag tgg aaa tgt ctg      100
 Phe Arg Asp Met Ala Ile Glu Phe Pro Gln Glu Glu Trp Lys Cys Leu
      10                  15                  20

 gac cct gct cag agg act tta tac agg gaa gtg atg gtg gag aac tac      148
 Asp Pro Ala Gln Arg Thr Leu Tyr Arg Glu Val Met Val Glu Asn Tyr
  25                  30                  35                  40

 agg aac ctg gtc ttt ctg gga atc tgt ctt cct gac ctg agt gtt atc      196
 Arg Asn Leu Val Phe Leu Gly Ile Cys Leu Pro Asp Leu Ser Val Ile
                  45                  50                  55

 tcc atg ttg gag caa agg aga gat ccc cgg aat ctg cag agt gaa gtg      244
 Ser Met Leu Glu Gln Arg Arg Asp Pro Arg Asn Leu Gln Ser Glu Val
              60                  65                  70

 aaa ata gca aac aat cca ggt ggc agg gag tgc atc aaa ggt gtg aac      292
 Lys Ile Ala Asn Asn Pro Gly Gly Arg Glu Cys Ile Lys Gly Val Asn
          75                  80                  85

 gca gag agc agc tct aaa ttg gga agc aat gcc gga aac aag tct ctt      340
 Ala Glu Ser Ser Ser Lys Leu Gly Ser Asn Ala Gly Asn Lys Ser Leu
      90                  95                 100

 aaa aat caa ctt gga tta acc ttt cag tta cat ctg agt gaa ctg cag      388
 Lys Asn Gln Leu Gly Leu Thr Phe Gln Leu His Leu Ser Glu Leu Gln
 105                 110                 115                 120

 cta ttt caa gct gaa agg aat att tct gga tgt aaa cat gtc gaa aaa      436
 Leu Phe Gln Ala Glu Arg Asn Ile Ser Gly Cys Lys His Val Glu Lys
                 125                 130                 135

 cct atc aac aac aat tcc tta gtt tca cca ctt caa aaa att tat tct      484
 Pro Ile Asn Asn Asn Ser Leu Val Ser Pro Leu Gln Lys Ile Tyr Ser
             140                 145                 150

 agt gtc aaa tcc cac att tta aat aaa tac aga aat gat ttt gat gat      532
 Ser Val Lys Ser His Ile Leu Asn Lys Tyr Arg Asn Asp Phe Asp Asp
         155                 160                 165

 tct cca ttt ctc cca caa gaa caa aaa gca caa ata agg gaa aaa ccg      580
 Ser Pro Phe Leu Pro Gln Glu Gln Lys Ala Gln Ile Arg Glu Lys Pro
     170                 175                 180

 tgt gaa tgt aat gag cat ggc aaa gcc ttt aga gtg tct tca agc ctt      628
 Cys Glu Cys Asn Glu His Gly Lys Ala Phe Arg Val Ser Ser Ser Leu
 185                 190                 195                 200

 gct aac cat caa gta atc cac act gca gat aac cct tac aaa tgt aat      676
 Ala Asn His Gln Val Ile His Thr Ala Asp Asn Pro Tyr Lys Cys Asn
                 205                 210                 215

 gaa tgt gac aag gtc ttc agt aac agt tca aac ctt gta caa cat caa      724
 Glu Cys Asp Lys Val Phe Ser Asn Ser Ser Asn Leu Val Gln His Gln
             220                 225                 230

 aga att cat act gga gag aag cct tac aag tgt cat gaa tgt ggc aag      772
 Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys His Glu Cys Gly Lys
         235                 240                 245

 ctc ttc aat cga att tca ctc ctt gca cga cat cag aga ata cat act      820
 Leu Phe Asn Arg Ile Ser Leu Leu Ala Arg His Gln Arg Ile His Thr
     250                 255                 260

 gga gag aaa cct tac aaa tgt cat gag tgt ggc aaa gtc ttc act caa      868
 Gly Glu Lys Pro Tyr Lys Cys His Glu Cys Gly Lys Val Phe Thr Gln
 265                 270                 275                 280

 aat tct cac ctt gca aat cat cac aga atc cac act gga gag aaa cct      916
 Asn Ser His Leu Ala Asn His His Arg Ile His Thr Gly Glu Lys Pro
                 285                 290                 295

 tac aaa tgt aat gag tgt ggc aag gtc ttc aac aga aat gca cac ctt      964
 Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe Asn Arg Asn Ala His Leu
             300                 305                 310

 gca cga cat cag aaa att cat agt gga gag aaa cct tac aaa tgt aag     1012
 Ala Arg His Gln Lys Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Lys
         315                 320                 325

 gaa tgt ggc aaa gca ttt tca ggg ggt tca ggc ctt act gct cat ctt     1060
 Glu Cys Gly Lys Ala Phe Ser Gly Gly Ser Gly Leu Thr Ala His Leu
     330                 335                 340

 gta att cac act gga gag aaa ctt tac aaa tgt aat aaa tgt ggc aag     1108
 Val Ile His Thr Gly Glu Lys Leu Tyr Lys Cys Asn Lys Cys Gly Lys
 345                 350                 355                 360

 gtc ttc aat cga aat gca cac ctt acc aga cat caa aga atc cat act     1156
 Val Phe Asn Arg Asn Ala His Leu Thr Arg His Gln Arg Ile His Thr
                 365                 370                 375

 gga gag aaa cct tat gaa tgt aaa gaa tgt ggc aag gtc ttc agg cac     1204
 Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Val Phe Arg His
             380                 385                 390

 aag ttt tgt cta acc aat cat cat aga atg cac acg gga gag caa cct     1252
 Lys Phe Cys Leu Thr Asn His His Arg Met His Thr Gly Glu Gln Pro
         395                 400                 405

 tac aaa tgt aat gaa tgt ggc aaa gca ttt aga gac tgt tca ggc ctt     1300
 Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Arg Asp Cys Ser Gly Leu
     410                 415                 420

 act gcc cat cta cta att cac act gga gag aaa cct tac aaa tgt aaa     1348
 Thr Ala His Leu Leu Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Lys
 425                 430                 435                 440

 gaa tgt gcc aag gtc ttc agg cat aga tta tcc cta agc aat cat cag     1396
 Glu Cys Ala Lys Val Phe Arg His Arg Leu Ser Leu Ser Asn His Gln
                 445                 450                 455

 aga ttt cat act gga gag aaa cct tac aga tgt gat gaa tgt ggc aag     1444
 Arg Phe His Thr Gly Glu Lys Pro Tyr Arg Cys Asp Glu Cys Gly Lys
             460                 465                 470

 gac ttc act cga aat tca aac ctt gca aat cat cac aga atc cat act     1492
 Asp Phe Thr Arg Asn Ser Asn Leu Ala Asn His His Arg Ile His Thr
         475                 480                 485

 gga gag aaa cct tac aaa tgc agt gaa tgt cac aaa gtc ttt agt cac     1540
 Gly Glu Lys Pro Tyr Lys Cys Ser Glu Cys His Lys Val Phe Ser His
     490                 495                 500

 aat tca cac ctt gca cga cat agg caa att cat act gga gag aag tct     1588
 Asn Ser His Leu Ala Arg His Arg Gln Ile His Thr Gly Glu Lys Ser
 505                 510                 515                 520

 tac aaa tgc aat gaa tgt ggc aag gtc ttc agc cac aag tta tac cta     1636
 Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe Ser His Lys Leu Tyr Leu
                 525                 530                 535

 aaa aaa cat gag aga att cat act ggg gag aaa ccg tac aga tgt cat     1684
 Lys Lys His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Arg Cys His
             540                 545                 550

 gaa tgt ggt aag gac ttc act cga aat tca aac ctg gca aat cat cac     1732
 Glu Cys Gly Lys Asp Phe Thr Arg Asn Ser Asn Leu Ala Asn His His
         555                 560                 565

 aga atc cat act gga gag aaa ccg tac aga tga                         1765
 Arg Ile His Thr Gly Glu Lys Pro Tyr Arg 
     570                 575





      <210> 436
      <211> 2038
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1896)

      <400> 436
  atg tcc cac caa gaa ggc agc aca gac ggc tta cca gac tta ggg act      48
  Met Ser His Gln Glu Gly Ser Thr Asp Gly Leu Pro Asp Leu Gly Thr
    1               5                  10                  15

 gaa agc ctg ttc agc agc cca gag gag cag tct gga gcc gtg gcg gcg       96
 Glu Ser Leu Phe Ser Ser Pro Glu Glu Gln Ser Gly Ala Val Ala Ala
              20                  25                  30

 aca gag gcc tcc tca gac att gac ata gcg acc tca gag ctg agt gtg      144
 Thr Glu Ala Ser Ser Asp Ile Asp Ile Ala Thr Ser Glu Leu Ser Val
          35                  40                  45

 aca gtg acc gga gat ggc agt gat agc agg gat ggt gga ttc ccc aac      192
 Thr Val Thr Gly Asp Gly Ser Asp Ser Arg Asp Gly Gly Phe Pro Asn
      50                  55                  60

 gat gcc agc aca gaa aat cga agc tca gac caa gaa agc gca agt gaa      240
 Asp Ala Ser Thr Glu Asn Arg Ser Ser Asp Gln Glu Ser Ala Ser Glu
  65                  70                  75                  80

 gac atc gaa ctt gag agc ttg gag gac ttt gag cat ttc ctc atg agt      288
 Asp Ile Glu Leu Glu Ser Leu Glu Asp Phe Glu His Phe Leu Met Ser
                  85                  90                  95

 ggt gaa agt tta ttc cat tac cct tta gtg gga gag gag gag aca gaa      336
 Gly Glu Ser Leu Phe His Tyr Pro Leu Val Gly Glu Glu Glu Thr Glu
             100                 105                 110

 agg gag gag gaa gac gaa gag ata caa gag gag gga ggg gag gag gag      384
 Arg Glu Glu Glu Asp Glu Glu Ile Gln Glu Glu Gly Gly Glu Glu Glu
         115                 120                 125

 gaa gag gag gag gag gag gag gag gag gag gag gag gag gag gag gag      432
 Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
     130                 135                 140

 gaa gaa gaa cag cct cgg gcg ggt cca caa ggc agt ggc ggc aac cat      480
 Glu Glu Glu Gln Pro Arg Ala Gly Pro Gln Gly Ser Gly Gly Asn His
 145                 150                 155                 160

 gag cag tat tcg tta gag gag gat cag gcg ctg gag gag tgg gtt tcc      528
 Glu Gln Tyr Ser Leu Glu Glu Asp Gln Ala Leu Glu Glu Trp Val Ser
                 165                 170                 175

 tca gag aca tct gcc ctg ccc cga cct cgc tgg cag gtc gtt act gct      576
 Ser Glu Thr Ser Ala Leu Pro Arg Pro Arg Trp Gln Val Val Thr Ala
             180                 185                 190

 ctt cac cag cgg cag ctg ggt tca cgt ccc cgc ttt gta tat gag gcc      624
 Leu His Gln Arg Gln Leu Gly Ser Arg Pro Arg Phe Val Tyr Glu Ala
         195                 200                 205

 tgt ggg gca aga gcc ttt gtg cag cgt ttc cgc ctg caa tat cgt ctt      672
 Cys Gly Ala Arg Ala Phe Val Gln Arg Phe Arg Leu Gln Tyr Arg Leu
     210                 215                 220

 gca gac cat gtc ggc tgt gtc aat act gta cac ttt aac cag cgt ggc      720
 Ala Asp His Val Gly Cys Val Asn Thr Val His Phe Asn Gln Arg Gly
 225                 230                 235                 240

 acc cgg ctg gcc agt agc ggt gat gac cta aag gtg ata gtg tgg gac      768
 Thr Arg Leu Ala Ser Ser Gly Asp Asp Leu Lys Val Ile Val Trp Asp
                 245                 250                 255

 tgg gtg cgg cag agg cca gta ctg aac ttt gaa agt ggt cac aca aat      816
 Trp Val Arg Gln Arg Pro Val Leu Asn Phe Glu Ser Gly His Thr Asn
             260                 265                 270

 aat gtc ttc cag gcc aag ttc ctt cct aac tgt ggt gat tcc act ctg      864
 Asn Val Phe Gln Ala Lys Phe Leu Pro Asn Cys Gly Asp Ser Thr Leu
         275                 280                 285

 gcc atg tgt gcc cgt gat ggg cag gta cgg gta gca gag tta att aat      912
 Ala Met Cys Ala Arg Asp Gly Gln Val Arg Val Ala Glu Leu Ile Asn
     290                 295                 300

 gca tca tat ttc aac aat act aag tgt gtg gcc cag cac agg gga cct      960
 Ala Ser Tyr Phe Asn Asn Thr Lys Cys Val Ala Gln His Arg Gly Pro
 305                 310                 315                 320

 gcc cac aag ttg gct ctg gag cct gac tct cct tat aag ttc ctc act     1008
 Ala His Lys Leu Ala Leu Glu Pro Asp Ser Pro Tyr Lys Phe Leu Thr
                 325                 330                 335

 tca ggt gaa gat gct gtt gtc ttc acc att gac ctc aga caa gac cgg     1056
 Ser Gly Glu Asp Ala Val Val Phe Thr Ile Asp Leu Arg Gln Asp Arg
             340                 345                 350

 cca gct tca aaa gtt gtg gta aca aga gaa aat gat aag aaa gtg gga     1104
 Pro Ala Ser Lys Val Val Val Thr Arg Glu Asn Asp Lys Lys Val Gly
         355                 360                 365

 ctg tat aca att act gtg aat ccc gcc aat acc tac caa ttt gca gtg     1152
 Leu Tyr Thr Ile Thr Val Asn Pro Ala Asn Thr Tyr Gln Phe Ala Val
     370                 375                 380

 ggt gga caa gat cag ttt gta agg att tat gac cag agg aaa att gat     1200
 Gly Gly Gln Asp Gln Phe Val Arg Ile Tyr Asp Gln Arg Lys Ile Asp
 385                 390                 395                 400

 aag aaa gaa aac aat ggc gtg ctc aag aaa ttc act cct cat cat ctg     1248
 Lys Lys Glu Asn Asn Gly Val Leu Lys Lys Phe Thr Pro His His Leu
                 405                 410                 415

 gtt aat tgt gat ttc cca aca aac atc acc tgc gtt gtg tac agc cac     1296
 Val Asn Cys Asp Phe Pro Thr Asn Ile Thr Cys Val Val Tyr Ser His
             420                 425                 430

 gat ggc aca gag ctg cta gcc agc tac aat gat gac gat att tac ctc     1344
 Asp Gly Thr Glu Leu Leu Ala Ser Tyr Asn Asp Asp Asp Ile Tyr Leu
         435                 440                 445

 ttc aac tcc tct cac agt gat ggt gct caa tac agt aag aga ttt aag     1392
 Phe Asn Ser Ser His Ser Asp Gly Ala Gln Tyr Ser Lys Arg Phe Lys
     450                 455                 460

 gga cac aga aat aat acc aca gtc aaa ggt gtt aat ttc tat ggc ccc     1440
 Gly His Arg Asn Asn Thr Thr Val Lys Gly Val Asn Phe Tyr Gly Pro
 465                 470                 475                 480

 agg agt gag ttt gta gtg agc ggt agt gat tgc ggg cac atc ttc ttc     1488
 Arg Ser Glu Phe Val Val Ser Gly Ser Asp Cys Gly His Ile Phe Phe
                 485                 490                 495

 tgg gag aaa tca tcc tgc caa atc atc cag ttc cta aag ggg agc aga     1536
 Trp Glu Lys Ser Ser Cys Gln Ile Ile Gln Phe Leu Lys Gly Ser Arg
             500                 505                 510

 gaa ggt aca ata aac tgt ctt gaa ccc cac cct tac cta cct gtg ttg     1584
 Glu Gly Thr Ile Asn Cys Leu Glu Pro His Pro Tyr Leu Pro Val Leu
         515                 520                 525

 gcg tgc agt ggc cta gat cat gat gtc aag atc tgg aca ccc aca gct     1632
 Ala Cys Ser Gly Leu Asp His Asp Val Lys Ile Trp Thr Pro Thr Ala
     530                 535                 540

 aaa gct gcc act gag ctt act ggg tta aag aag gtg att aag aag aac     1680
 Lys Ala Ala Thr Glu Leu Thr Gly Leu Lys Lys Val Ile Lys Lys Asn
 545                 550                 555                 560

 aag tgg gaa cga gat gaa gac agc ttg cac cat ggc agc ctg ttt gac     1728
 Lys Trp Glu Arg Asp Glu Asp Ser Leu His His Gly Ser Leu Phe Asp
                 565                 570                 575

 cag tac atg ctt tgg ttc ctc ctg cgt cac gtg acg cag aga ggt cgt     1776
 Gln Tyr Met Leu Trp Phe Leu Leu Arg His Val Thr Gln Arg Gly Arg
             580                 585                 590

 cac cag gac tgg aga agt ggt gaa gct gaa ttt cca gat gaa gaa tcg     1824
 His Gln Asp Trp Arg Ser Gly Glu Ala Glu Phe Pro Asp Glu Glu Ser
         595                 600                 605

 gat gag tct tcc agc act tca gag aca tct gag gag gag gtc caa gac     1872
 Asp Glu Ser Ser Ser Thr Ser Glu Thr Ser Glu Glu Glu Val Gln Asp
     610                 615                 620

 cga gtg cag tgc atg cca tcc tga aggcctcata tccagtccag ctacatgcca    1926
 Arg Val Gln Cys Met Pro Ser 
 625                 630

 cctaagtaca ctggacttta aaattcagtt tgactaattt agaattgtca atagattaat   1986

 agatttgctt tttgtcttct attttccata atatatgctg aaaaccgtct ct           2038




      <210> 437
      <211> 6288
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (740)..(5020)

      <400> 437
 cttccatgtg tgaaagctac ttggcatgaa tgcctgggcc gtaccaagtg tcaccgcagc     60

 aagaggggga gtcagaagaa aaacagatca gaccaagcag acaataggcc cctaaagtgt    120

 tccccctaag ttgctttgat gttgtcctgg tgtcttgata ccaggaggcc agggattgcg    180

 ggaaaagggt cttttttgtc ttcattcact ttcccccctc agtttctgaa atgattctcc    240

 agaatttctc ctcataaaaa aggactgaat gtgggcccag ttggcgtcat tctgctttga    300

 cctaaacatt cccatctgat tgggtggcag agatcatttt tggaaagttc ttccgtgtcc    360

 cgatgtagaa gaaatagcaa attggacata ttgaaagaca agggtcatct ttgagaaggg    420

 ggttcctgga ctcctcacct ccaggatgag cactgcagtg tcgtgaccct tggggttttg    480

 tatgccctgg agatgcgaga ttttcctctg gcagcaggag gcacgcaccc agagaatgct    540

 ggagctgcaa ggggaaagga cccacttcca cagcagagaa aaacaaagag gaaaaaggca    600

 tacaggcagc gagcgctaag ggacgcaccc agcaagcagt gggccagtgc cactgccccc    660

 agcagctgtt tctgctgcaa cccgagagga actcggtgag cctgtcccgt ttgtgactgc    720

 aagctcagga tttcaatca atg cat tcc agt aac cct aaa gtg agg agc tct     772
                      Met His Ser Ser Asn Pro Lys Val Arg Ser Ser
                        1               5                  10

 cca tca gga aac aca cag agt agc cct aag tca aag cag gag gtg atg      820
 Pro Ser Gly Asn Thr Gln Ser Ser Pro Lys Ser Lys Gln Glu Val Met
              15                  20                  25

 gtc cgt ccc cct aca gtg atg tcc cca tct gga aac ccc cag ctg gat      868
 Val Arg Pro Pro Thr Val Met Ser Pro Ser Gly Asn Pro Gln Leu Asp
          30                  35                  40

 tcc aaa ttc tcc aat cag ggt aaa cag ggg ggc tca gcc agc caa tcc      916
 Ser Lys Phe Ser Asn Gln Gly Lys Gln Gly Gly Ser Ala Ser Gln Ser
      45                  50                  55

 cag cca tcc ccc tgt gac tcc aag agt ggg ggc cat acc cct aaa gca      964
 Gln Pro Ser Pro Cys Asp Ser Lys Ser Gly Gly His Thr Pro Lys Ala
  60                  65                  70                  75

 ctc cct ggc cca ggt ggg agc atg ggg ctg aag aat ggg gct gga aat     1012
 Leu Pro Gly Pro Gly Gly Ser Met Gly Leu Lys Asn Gly Ala Gly Asn
                  80                  85                  90

 ggt gcc aag ggc aag ggg aaa agg gag cga agt att tcc gcc gac tcc     1060
 Gly Ala Lys Gly Lys Gly Lys Arg Glu Arg Ser Ile Ser Ala Asp Ser
              95                 100                 105

 ttt gat cag aga gat cct ggg act cca aac gat gac tct gac att aaa     1108
 Phe Asp Gln Arg Asp Pro Gly Thr Pro Asn Asp Asp Ser Asp Ile Lys
         110                 115                 120

 gaa tgt aat tct gct gac cac ata aag tcc cag gat tcc cag cac aca     1156
 Glu Cys Asn Ser Ala Asp His Ile Lys Ser Gln Asp Ser Gln His Thr
     125                 130                 135

 cca cac tcg atg acc cca tca aat gct aca gcc ccc agg tct tct acc     1204
 Pro His Ser Met Thr Pro Ser Asn Ala Thr Ala Pro Arg Ser Ser Thr
 140                 145                 150                 155

 ccc tcc cat ggc caa act act gcc aca gag ccc aca cct gct cag aag     1252
 Pro Ser His Gly Gln Thr Thr Ala Thr Glu Pro Thr Pro Ala Gln Lys
                 160                 165                 170

 act cca gcc aaa gtg gtg tac gtg ttt tct act gag atg gcc aat aaa     1300
 Thr Pro Ala Lys Val Val Tyr Val Phe Ser Thr Glu Met Ala Asn Lys
             175                 180                 185

 gct gca gaa gct gtt ttg aag ggc cag gtt gaa act atc gtc tct ttc     1348
 Ala Ala Glu Ala Val Leu Lys Gly Gln Val Glu Thr Ile Val Ser Phe
         190                 195                 200

 cac atc cag aac att tct aac aac aag aca gag aga agc aca gcg cct     1396
 His Ile Gln Asn Ile Ser Asn Asn Lys Thr Glu Arg Ser Thr Ala Pro
     205                 210                 215

 ctg aac aca cag ata tct gcc ctt cgg aat gat ccg aaa cct ctc cca     1444
 Leu Asn Thr Gln Ile Ser Ala Leu Arg Asn Asp Pro Lys Pro Leu Pro
 220                 225                 230                 235

 caa cag ccc cca gct ccg gcc aac cag gac cag aat tct tcc cag aat     1492
 Gln Gln Pro Pro Ala Pro Ala Asn Gln Asp Gln Asn Ser Ser Gln Asn
                 240                 245                 250

 acc aga ctg cag cca act cca ccc att ccg gca cca gca ccc aag cct     1540
 Thr Arg Leu Gln Pro Thr Pro Pro Ile Pro Ala Pro Ala Pro Lys Pro
             255                 260                 265

 gcc gca ccc cca cgt ccc ctg gac cgg gag agt cct ggg gta gaa aac     1588
 Ala Ala Pro Pro Arg Pro Leu Asp Arg Glu Ser Pro Gly Val Glu Asn
         270                 275                 280

 aaa ctg att cct tct gta gga agt cct gcc agc tcc act cca ctg ccc     1636
 Lys Leu Ile Pro Ser Val Gly Ser Pro Ala Ser Ser Thr Pro Leu Pro
     285                 290                 295

 cca gat ggt act ggg ccc aac tca act ccc aac aat agg gca gtg acc     1684
 Pro Asp Gly Thr Gly Pro Asn Ser Thr Pro Asn Asn Arg Ala Val Thr
 300                 305                 310                 315

 cct gtc tcc cag ggg agc aat agc tct tca gca gat ccc aaa gcc cct     1732
 Pro Val Ser Gln Gly Ser Asn Ser Ser Ser Ala Asp Pro Lys Ala Pro
                 320                 325                 330

 ccg cct cca cca gtg tcc agt ggc gag ccc ccc aca ctg gga gag aat     1780
 Pro Pro Pro Pro Val Ser Ser Gly Glu Pro Pro Thr Leu Gly Glu Asn
             335                 340                 345

 ccc gat ggc cta tct cag gag cag ctg gag cac cgg gag cgc tcc tta     1828
 Pro Asp Gly Leu Ser Gln Glu Gln Leu Glu His Arg Glu Arg Ser Leu
         350                 355                 360

 caa act ctc aga gat atc cag cgc atg ctt ttt cct gat gag aaa gaa     1876
 Gln Thr Leu Arg Asp Ile Gln Arg Met Leu Phe Pro Asp Glu Lys Glu
     365                 370                 375

 ttc aca gga gca caa agt ggg gga ccg cag cag aat cct ggg gta tta     1924
 Phe Thr Gly Ala Gln Ser Gly Gly Pro Gln Gln Asn Pro Gly Val Leu
 380                 385                 390                 395

 gat ggg cct cag aaa aaa cca gaa ggg cca ata cag gcc atg atg gcc     1972
 Asp Gly Pro Gln Lys Lys Pro Glu Gly Pro Ile Gln Ala Met Met Ala
                 400                 405                 410

 caa tcc caa agc cta ggt aag gga cct ggg ccc cgg aca gac gtg gga     2020
 Gln Ser Gln Ser Leu Gly Lys Gly Pro Gly Pro Arg Thr Asp Val Gly
             415                 420                 425

 gct cca ttt ggc cct caa gga cat aga gat gta ccc ttt tct cca gat     2068
 Ala Pro Phe Gly Pro Gln Gly His Arg Asp Val Pro Phe Ser Pro Asp
         430                 435                 440

 gaa atg gtt cca cct tct atg aac tcc cag tct ggg acc ata gga ccc     2116
 Glu Met Val Pro Pro Ser Met Asn Ser Gln Ser Gly Thr Ile Gly Pro
     445                 450                 455

 gac cac ctt gac cat atg act ccc gag cag ata gcg tgg ctg aaa ctg     2164
 Asp His Leu Asp His Met Thr Pro Glu Gln Ile Ala Trp Leu Lys Leu
 460                 465                 470                 475

 cag cag gag ttt tat gaa gag aag agg agg aag ccg gaa caa gtg gtt     2212
 Gln Gln Glu Phe Tyr Glu Glu Lys Arg Arg Lys Pro Glu Gln Val Val
                 480                 485                 490

 gtc cag cag tgt tcc ctc cag gac atg atg gtc cat cag cac ggg cct     2260
 Val Gln Gln Cys Ser Leu Gln Asp Met Met Val His Gln His Gly Pro
             495                 500                 505

 cgg gga gtg gtc cga gga ccc ccc cct cca tac cag atg acc cct agt     2308
 Arg Gly Val Val Arg Gly Pro Pro Pro Pro Tyr Gln Met Thr Pro Ser
         510                 515                 520

 gaa ggc tgg gca cct ggg ggt aca gag cca ttt tct gat ggt atc aac     2356
 Glu Gly Trp Ala Pro Gly Gly Thr Glu Pro Phe Ser Asp Gly Ile Asn
     525                 530                 535

 atg cca cat tct ctg ccc ccg agg ggc atg gct ccc cac ccc aac atg     2404
 Met Pro His Ser Leu Pro Pro Arg Gly Met Ala Pro His Pro Asn Met
 540                 545                 550                 555

 cca ggg agc cag atg cgc ctc cct gga ttt gca ggc atg ata aac tct     2452
 Pro Gly Ser Gln Met Arg Leu Pro Gly Phe Ala Gly Met Ile Asn Ser
                 560                 565                 570

 gaa atg gaa ggg ccg aat gtc ccc aac cct gca tct aga cca ggt ctt     2500
 Glu Met Glu Gly Pro Asn Val Pro Asn Pro Ala Ser Arg Pro Gly Leu
             575                 580                 585

 tct gga gtc agt tgg cca gat gat gtg cca aaa atc cca gat ggt cga     2548
 Ser Gly Val Ser Trp Pro Asp Asp Val Pro Lys Ile Pro Asp Gly Arg
         590                 595                 600

 aat ttt cct cct ggc cag ggc att ttc agc ggt cct ggc cga ggg gaa     2596
 Asn Phe Pro Pro Gly Gln Gly Ile Phe Ser Gly Pro Gly Arg Gly Glu
     605                 610                 615

 cgc ttc cca aac ccc caa gga ttg tct gaa gag atg ttt cag cag cag     2644
 Arg Phe Pro Asn Pro Gln Gly Leu Ser Glu Glu Met Phe Gln Gln Gln
 620                 625                 630                 635

 ctg gca gag aaa cag ctg ggt ctc ccc cca ggg atg gcc atg gaa ggc     2692
 Leu Ala Glu Lys Gln Leu Gly Leu Pro Pro Gly Met Ala Met Glu Gly
                 640                 645                 650

 atc agg ccc agc atg gag atg aac agg atg att cca ggc tcc cag cgc     2740
 Ile Arg Pro Ser Met Glu Met Asn Arg Met Ile Pro Gly Ser Gln Arg
             655                 660                 665

 cac atg gag cct ggg aat aac ccc att ttc cct cga ata cca gtt gag     2788
 His Met Glu Pro Gly Asn Asn Pro Ile Phe Pro Arg Ile Pro Val Glu
         670                 675                 680

 ggc cct ctg agt cct tct agg ggt gac ttt cca aaa gga att ccc cca     2836
 Gly Pro Leu Ser Pro Ser Arg Gly Asp Phe Pro Lys Gly Ile Pro Pro
     685                 690                 695

 cag atg ggc cct ggt cgg gaa ctt gag ttt ggg atg gtt cct agt ggg     2884
 Gln Met Gly Pro Gly Arg Glu Leu Glu Phe Gly Met Val Pro Ser Gly
 700                 705                 710                 715

 atg aag gga gat gtc aat cta aat gtc aac atg gga tcc aac tct cag     2932
 Met Lys Gly Asp Val Asn Leu Asn Val Asn Met Gly Ser Asn Ser Gln
                 720                 725                 730

 atg ata cct cag aag atg aga gag gct ggg gcg ggc cct gag gag atg     2980
 Met Ile Pro Gln Lys Met Arg Glu Ala Gly Ala Gly Pro Glu Glu Met
             735                 740                 745

 ctg aaa tta cgc cca ggt ggc tca gac atg ctg cct gct cag cag aag     3028
 Leu Lys Leu Arg Pro Gly Gly Ser Asp Met Leu Pro Ala Gln Gln Lys
         750                 755                 760

 atg gtg cca ctg cca ttt ggt gag cac ccc cag cag gag tat ggc atg     3076
 Met Val Pro Leu Pro Phe Gly Glu His Pro Gln Gln Glu Tyr Gly Met
     765                 770                 775

 ggc ccc aga cca ttc ctt ccc atg tct cag ggt cca ggc agc aac agt     3124
 Gly Pro Arg Pro Phe Leu Pro Met Ser Gln Gly Pro Gly Ser Asn Ser
 780                 785                 790                 795

 ggc ttg cgg aat ctc aga gaa cca att ggg ccc gac cag agg act aac     3172
 Gly Leu Arg Asn Leu Arg Glu Pro Ile Gly Pro Asp Gln Arg Thr Asn
                 800                 805                 810

 agc cgg ctc agt cat atg cca cca cta cct ctc aac cct tcc agt aac     3220
 Ser Arg Leu Ser His Met Pro Pro Leu Pro Leu Asn Pro Ser Ser Asn
             815                 820                 825

 ccc acc agc ctc aac aca gct cct cca gtt cag cgc ggc ctg ggg cgg     3268
 Pro Thr Ser Leu Asn Thr Ala Pro Pro Val Gln Arg Gly Leu Gly Arg
         830                 835                 840

 aag ccc ttg gat ata tct gtg gca ggc agc cag gtg cat tcc cca ggc     3316
 Lys Pro Leu Asp Ile Ser Val Ala Gly Ser Gln Val His Ser Pro Gly
     845                 850                 855

 att aac cct ctg aag tct ccc acg atg cac caa gtc cag tca cca atg     3364
 Ile Asn Pro Leu Lys Ser Pro Thr Met His Gln Val Gln Ser Pro Met
 860                 865                 870                 875

 ctg ggc tcg ccc tcg ggg aac ctc aag tcc ccc cag act cca tcg cag     3412
 Leu Gly Ser Pro Ser Gly Asn Leu Lys Ser Pro Gln Thr Pro Ser Gln
                 880                 885                 890

 ctg gca ggc atg ctg gcg ggc cca gct gct gct gct tcc att aag tcc     3460
 Leu Ala Gly Met Leu Ala Gly Pro Ala Ala Ala Ala Ser Ile Lys Ser
             895                 900                 905

 ccc cct gtt ttg ggg tct gct gct gct tca cct gtc cac ctc aag tct     3508
 Pro Pro Val Leu Gly Ser Ala Ala Ala Ser Pro Val His Leu Lys Ser
         910                 915                 920

 cca tca ctt cct gcc ccg tca cct gga tgg acc tct tct cca aaa cct     3556
 Pro Ser Leu Pro Ala Pro Ser Pro Gly Trp Thr Ser Ser Pro Lys Pro
     925                 930                 935

 ccc ctt cag agt cct ggg atc cct cca aac cat aaa gca ccc ctc acc     3604
 Pro Leu Gln Ser Pro Gly Ile Pro Pro Asn His Lys Ala Pro Leu Thr
 940                 945                 950                 955

 atg gcc tcc cca gcc atg ctg gga aat gta gag tca ggt ggc ccc cca     3652
 Met Ala Ser Pro Ala Met Leu Gly Asn Val Glu Ser Gly Gly Pro Pro
                 960                 965                 970

 cct cct aca gcc agc cag cct gcc tct gtg aat atc cct gga agt ctt     3700
 Pro Pro Thr Ala Ser Gln Pro Ala Ser Val Asn Ile Pro Gly Ser Leu
             975                 980                 985

 ccc tct agt aca cct tat acc atg cct cca gag cca acc ctt tcc cag     3748
 Pro Ser Ser Thr Pro Tyr Thr Met Pro Pro Glu Pro Thr Leu Ser Gln
         990                 995                1000

 aac cca ctc tct att atg atg tct cga atg tcc aag ttt gca atg ccc     3796
 Asn Pro Leu Ser Ile Met Met Ser Arg Met Ser Lys Phe Ala Met Pro
    1005                1010                1015

 agt tcc acc ccg tta tac cat gat gct atc aag act gtg gcc agc tca     3844
 Ser Ser Thr Pro Leu Tyr His Asp Ala Ile Lys Thr Val Ala Ser Ser
1020                1025                1030                1035

 gat gac gac tcc cct cca gct cgt tct ccc aac ttg cca tca atg aat     3892
 Asp Asp Asp Ser Pro Pro Ala Arg Ser Pro Asn Leu Pro Ser Met Asn
                1040                1045                1050

 aat atg cca gga atg ggc att aat aca cag aat cct cga att tca ggt     3940
 Asn Met Pro Gly Met Gly Ile Asn Thr Gln Asn Pro Arg Ile Ser Gly
            1055                1060                1065

 cca aac ccc gtg gtt ccg atg cca acc ctc agc cca atg gaa atg acc     3988
 Pro Asn Pro Val Val Pro Met Pro Thr Leu Ser Pro Met Glu Met Thr
        1070                1075                1080

 cag cca ctt tct cac tcc aat cag atg ccc tct cca aat gcc gtg gga     4036
 Gln Pro Leu Ser His Ser Asn Gln Met Pro Ser Pro Asn Ala Val Gly
    1085                1090                1095

 ccc aac ata cct cct cat ggg gtc cca atg ggg cct ggc ttg atg tca     4084
 Pro Asn Ile Pro Pro His Gly Val Pro Met Gly Pro Gly Leu Met Ser
1100                1105                1110                1115

 cac aat cct atc atg ggg cat ggg tcc caa gag cca ccg atg gta cct     4132
 His Asn Pro Ile Met Gly His Gly Ser Gln Glu Pro Pro Met Val Pro
                1120                1125                1130

 caa gga cgg atg ggc ttc ccc cag ggc ttc cct cca gta cag tct ccc     4180
 Gln Gly Arg Met Gly Phe Pro Gln Gly Phe Pro Pro Val Gln Ser Pro
            1135                1140                1145

 cca cag cag gtt cca ttc cct cac aat ggc ccc agt ggg ggg cag ggc     4228
 Pro Gln Gln Val Pro Phe Pro His Asn Gly Pro Ser Gly Gly Gln Gly
        1150                1155                1160

 agc ttc cca gga ggg atg ggt ttc cca gga gaa ggc ccc ctt ggc cgc     4276
 Ser Phe Pro Gly Gly Met Gly Phe Pro Gly Glu Gly Pro Leu Gly Arg
    1165                1170                1175

 ccc agc aac ctg ccc caa agt tca gca gat gca gca ctt tgc aag cct     4324
 Pro Ser Asn Leu Pro Gln Ser Ser Ala Asp Ala Ala Leu Cys Lys Pro
1180                1185                1190                1195

 gga ggc ccc ggg ggt cct gac tcc ttc act gtc ctg ggg aac agc atg     4372
 Gly Gly Pro Gly Gly Pro Asp Ser Phe Thr Val Leu Gly Asn Ser Met
                1200                1205                1210

 cct tcg gtg ttt aca gac cca gat ctg cag gag gtc atc cga cct gga     4420
 Pro Ser Val Phe Thr Asp Pro Asp Leu Gln Glu Val Ile Arg Pro Gly
            1215                1220                1225

 gcc acc gga ata cct gag ttt gat cta tcc cgc att att cca tct gag     4468
 Ala Thr Gly Ile Pro Glu Phe Asp Leu Ser Arg Ile Ile Pro Ser Glu
        1230                1235                1240

 aag ccc agc cag acg ctg caa tat ttc cct cga ggg gaa gtt cca ggc     4516
 Lys Pro Ser Gln Thr Leu Gln Tyr Phe Pro Arg Gly Glu Val Pro Gly
    1245                1250                1255

 cgt aaa cag ccc cag ggt cct gga cct ggg ttt tca cac atg cag ggg     4564
 Arg Lys Gln Pro Gln Gly Pro Gly Pro Gly Phe Ser His Met Gln Gly
1260                1265                1270                1275

 atg atg ggc gaa caa gcc ccc aga atg gga cta gca tta cct ggc atg     4612
 Met Met Gly Glu Gln Ala Pro Arg Met Gly Leu Ala Leu Pro Gly Met
                1280                1285                1290

 gga ggt cca ggg cca gtg gga act ccg gac atc cct ctt ggt aca gct     4660
 Gly Gly Pro Gly Pro Val Gly Thr Pro Asp Ile Pro Leu Gly Thr Ala
            1295                1300                1305

 cca tcc atg cca ggc cac aac ccc atg aga cca cca gcc ttt ctc caa     4708
 Pro Ser Met Pro Gly His Asn Pro Met Arg Pro Pro Ala Phe Leu Gln
        1310                1315                1320

 caa ggc atg atg gga cct cac cat cgg atg atg tca cca gca caa tct     4756
 Gln Gly Met Met Gly Pro His His Arg Met Met Ser Pro Ala Gln Ser
    1325                1330                1335

 aca atg ccc ggc cag ccc acc ctg atg agc aat cca gct gct gcc gtg     4804
 Thr Met Pro Gly Gln Pro Thr Leu Met Ser Asn Pro Ala Ala Ala Val
1340                1345                1350                1355

 ggc atg att cct ggc aag gat cgg ggg cct gcc ggg ctc tac acc cac     4852
 Gly Met Ile Pro Gly Lys Asp Arg Gly Pro Ala Gly Leu Tyr Thr His
                1360                1365                1370

 cct ggg cct gtg ggc tct cca ggc atg atg atg tcc atg cag ggc atg     4900
 Pro Gly Pro Val Gly Ser Pro Gly Met Met Met Ser Met Gln Gly Met
            1375                1380                1385

 atg gga ccc caa cag aac atc atg atc ccc cca cag atg agg ccc cgg     4948
 Met Gly Pro Gln Gln Asn Ile Met Ile Pro Pro Gln Met Arg Pro Arg
        1390                1395                1400

 ggc atg gct gct gac gtg ggc atg ggt gga ttt agc caa gga cct ggc     4996
 Gly Met Ala Ala Asp Val Gly Met Gly Gly Phe Ser Gln Gly Pro Gly
    1405                1410                1415

 aac cca gga aac atg atg ttt taa gctgctaaga tgggatgtgc cgatccttgt    5050
 Asn Pro Gly Asn Met Met Phe 
1420                1425

 caagatgaga ttccaggtcc tgagagctgc tttgagggag ttccaggagt acttactatt   5110

 ggtcatgcaa taggagaaca gagacccgag ggctgctttg ggggaggggg gaactcgaga   5170

 atgtatggat ttacctgaaa acaaattatt catttaatca acaggtgtgt tttttttaag   5230

 atttattttt taaaaattat ttttgtggac ttgggtatca atgatggcac ctacttttgg   5290

 gaatctgtag ctgtgctttg agaattgcca tcggtcatgt gttgcaccgt tctctgtatg   5350

 tttacgtcct ttggactggc ttctcccagg attcttttct gtttttgttt ttttgatttg   5410

 ggctttattt ttttctgtgt actgtactat attgtaaaag ggattttagc agagacttta   5470

 gtctttgggg caagaggaga acaggaatgc tgggctgttt actttaggtg gagaatccat   5530

 cttcagacct ttggactatt ttctttcaac tgcagtgtat agaaaaacca aactacgacc   5590

 tcagagcaga gtattaatga aaaacacaaa aaaaggaact aagttcagcg aggggtgggg   5650

 ggagggggga gatttttctt ttgaaaaata atgactctta ggacatttgt ttttaagttc   5710

 aagtgctctt cagcactgtc ttgtctccca atataccaac ccactggcac atttttctct   5770

 tgttttctct ctccgatttt gctctgtctc ctcagttaag tgtttccttc ctttgtgccc   5830

 cccgctggtg accctctgct tccctctctc tttccctttg gcagctgcaa tacacagtgt   5890

 tattttgggg aaataaatct agcaaagcct cgccttccat gccgagcgtc ctcttggctc   5950

 tgagagggaa aggtctgtcc ttgggatgct ctctggtctt ttttccccct aagtctttct   6010

 ctttcccatc atacccttcc ctgcccacct tgttttctgt tctcctttta ttaggaattc   6070

 ccaagtgaat tttattaatg tgggagtgga acagatgcta aaagctatcc aggattttgt   6130

 ttctgtttgt tttaaatttt gtggttcctt ccctttcctc cccctcccat gcgtaagacg   6190

 ttctgtgtaa cctccattaa atttggtaca aaaccactcg ccagagctgt ggtgtcagaa   6250

 aaataaaata tattgtttct tacaaaaaaa aaaaaaaa                           6288




      <210> 438
      <211> 1319
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(609)

      <400> 438
  atg aat ggc cag aat ttc aga gct gcc ttt aca gag ctg gtt atg ttt      48
  Met Asn Gly Gln Asn Phe Arg Ala Ala Phe Thr Glu Leu Val Met Phe
    1               5                  10                  15

 gag ctg ggt att agg ttg aaa agg aat ttg caa tgc agg agc agg aag       96
 Glu Leu Gly Ile Arg Leu Lys Arg Asn Leu Gln Cys Arg Ser Arg Lys
              20                  25                  30

 gaa gaa ctg gat att cag gca aga gta gcc gca ggt gca agg aca cag      144
 Glu Glu Leu Asp Ile Gln Ala Arg Val Ala Ala Gly Ala Arg Thr Gln
          35                  40                  45

 aac agg gag tca gtg acc ttc gag gat gtg gcc gtc tac ttc tct gag      192
 Asn Arg Glu Ser Val Thr Phe Glu Asp Val Ala Val Tyr Phe Ser Glu
      50                  55                  60

 aac gaa tgg atc ggc ctg ggc cct gct cag aga gcc ctg tac agg gat      240
 Asn Glu Trp Ile Gly Leu Gly Pro Ala Gln Arg Ala Leu Tyr Arg Asp
  65                  70                  75                  80

 gtg atg ctg gag aat tat ggg gct gtg gct tcc ctg gca gca ttc cca      288
 Val Met Leu Glu Asn Tyr Gly Ala Val Ala Ser Leu Ala Ala Phe Pro
                  85                  90                  95

 ttt ccg aaa ccg gct ctg att tcc cag ctg gag cga ggg gaa aca ccc      336
 Phe Pro Lys Pro Ala Leu Ile Ser Gln Leu Glu Arg Gly Glu Thr Pro
             100                 105                 110

 tgg tgc tcg gtt cct cgg gga gct ctg gat gga gag gcc cca agg ggc      384
 Trp Cys Ser Val Pro Arg Gly Ala Leu Asp Gly Glu Ala Pro Arg Gly
         115                 120                 125

 atc tcc tca gta gaa aag agc tgg gct ccc tca ctg ttt cct ggc aca      432
 Ile Ser Ser Val Glu Lys Ser Trp Ala Pro Ser Leu Phe Pro Gly Thr
     130                 135                 140

 cgg tat gat att gag ttc cat gat tat gca tgt acc ttg ggt tac aac      480
 Arg Tyr Asp Ile Glu Phe His Asp Tyr Ala Cys Thr Leu Gly Tyr Asn
 145                 150                 155                 160

 ccc cct ggc ggc aga acc tct att gtg tcc ttc ttt gta ttg ccc aca      528
 Pro Pro Gly Gly Arg Thr Ser Ile Val Ser Phe Phe Val Leu Pro Thr
                 165                 170                 175

 gag cct gtt ggt gac ctg cac aca gga gcc ctc cag tca gta ctg att      576
 Glu Pro Val Gly Asp Leu His Thr Gly Ala Leu Gln Ser Val Leu Ile
             180                 185                 190

 gaa tta ctc aag gct gcc tct ctg caa agt tga gcagcatt tccatttccc      627
 Glu Leu Leu Lys Ala Ala Ser Leu Gln Ser 
         195                 200

 aaaccggctc tgatttccca gctggagcga ggggaaacac cctggtgctc ggttcctcgg    687

 ggagctctgg atggagaggc cccaaggggc atctcctcag cacctgagac ttttaccttt    747

 acccagaaag gaataaaaga ggtcagatga tgacagctgt gtccttaaca accaggcccc    807

 aggaatcagt ggcttttgag gacgtggctg tgtacttcac tacgaaggaa tgggccatca    867

 tggtgcctgc cgagagggcc ttgtacaggg atgtgatgct ggagaactat gaggctgtgg    927

 cctttgtagt gccacccact tccaaaccag ctttggtctc tcatctggag caagggaaag    987

 agtcctgttt cacccagcca cagggagtcc taagcaggaa tgactggaga gcaggctgga   1047

 taggatactt ggaactaaga agatatactt acttagctaa agcagtgtta cgtagcaatc   1107

 agtatcaaaa aattttcgaa atcgtcaatg ctgggaagac aggagaaaag cttaattctt   1167

 gacatttaaa taccagtttt ccaagtaagg agttgatgta agagccacct taaacgatgt   1227

 caaatacaca ttttcttttt ctgtagactg gtagatttaa tgtttttcat tcattaaaat   1287

 aactcatttt gatgtacaaa aaaaaaaaaa aa                                 1319




      <210> 439
      <211> 1248
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (78)..(440)

      <400> 439
 cctcaggtgc cagtgcggag gacgctgctg tccaggagat gggtctggca cagggctagg     60

 gtccccccac cccgccc   atg ggt ctc cac tca cct tgc gcc ttc ctc cca     110
                      Met Gly Leu His Ser Pro Cys Ala Phe Leu Pro
                        1               5                  10

 cag gag cgg gat gcc ggg gtt ctg tcc agg gtc tgc ggc ctt ctc cgg      158
 Gln Glu Arg Asp Ala Gly Val Leu Ser Arg Val Cys Gly Leu Leu Arg
              15                  20                  25

 cag ctg cac acg gcc tac agt ggc ctg gtc tcc agc ctc cag ggc ctg      206
 Gln Leu His Thr Ala Tyr Ser Gly Leu Val Ser Ser Leu Gln Gly Leu
          30                  35                  40

 ccc gcc gag ctc cag cag cca gtg ggg cgg gcg cgg cac agc ctc tgt      254
 Pro Ala Glu Leu Gln Gln Pro Val Gly Arg Ala Arg His Ser Leu Cys
      45                  50                  55

 gag ctc tat ggc atc gtg gcc tca gct ggc tct gta gag gag ctg ccc      302
 Glu Leu Tyr Gly Ile Val Ala Ser Ala Gly Ser Val Glu Glu Leu Pro
  60                  65                  70                  75

 gca gag cgg ctg gtg cag agc cgc gag ggt gtg cac cag gct tgg cag      350
 Ala Glu Arg Leu Val Gln Ser Arg Glu Gly Val His Gln Ala Trp Gln
                  80                  85                  90

 ggg tta gag cag ctg ctg gag ggc cta cag cac aat ccc ccg ctc agc      398
 Gly Leu Glu Gln Leu Leu Glu Gly Leu Gln His Asn Pro Pro Leu Ser
              95                 100                 105

 tgg ctg gta ggg ccc ttc gcc ttg ccc gct ggc ggg cag tag ctgtagg      447
 Trp Leu Val Gly Pro Phe Ala Leu Pro Ala Gly Gly Gln 
         110                 115                 120

 agcctgcagg cccggcgcgg ggtcgccctg ctctgtccag ggaggagctg cctcagaact    507

 ttctccccgc ccccaaacct ggatcggttc cctaaagccc tagacctttg gggctgcagc    567

 tggctgagcg ccgaggggct gcggaggcag tgcccttctt aactgagcca ccccacgccc    627

 tgctccgggc ctgcctgcat ctcccacctc ctccccagcg ctgcctgccc ctctcggagc    687

 ctggggtcac tcagaccacc agccaagagc cttcccttga agtccccaag caagcactgc    747

 aattaggaaa gagaaaaagc agcgtgccca gcctggaagg gcatctgttt gccccgctag    807

 caaccctttt atatctagca gggctcttcc agtcctgcag cacgggcccc cagctatcag    867

 cggtgcaggc agtgctgtgg catcccaggc tccgggcagc tccgttctca tgctgaaagt    927

 gggtctccgg ccttagcaca cacaccttga gggtcttaag aaccacattc cctcatagta    987

 gaaagtacta gaaaaagcga cactgccatc atcatcccaa ggcaggctgc tactgccttt   1047

 gctgaccccc ggggtggcct cacggtgggg acaaagctgc caggagccac agcagccaca   1107

 gctggggctt tgcaccagcc tggcttgaga ctgagcagtt tgcagggggt ggggggtgca   1167

 aaaaacaagc aaacaggctg ctgctgcctc cagctgccca ccacaggcct gccccaggca   1227

 cctggggctc tgaggcccct g                                             1248




      <210> 440
      <211> 527
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (12)..(275)

      <400> 440
 agatcctcac c atg gag aag gaa gtg gcc cag agc ctt ctc aat gcg aag      50
              Met Glu Lys Glu Val Ala Gln Ser Leu Leu Asn Ala Lys
                1               5                  10

 gag cag ctc acc aga gag ctg gaa gag ctc aag gag att gag gcg gat       98
 Glu Gln Leu Thr Arg Glu Leu Glu Glu Leu Lys Glu Ile Glu Ala Asp
      15                  20                  25

 ctg gag cga cag gag aag gag gtc gac gag gac acg aca gtc aca atc      146
 Leu Glu Arg Gln Glu Lys Glu Val Asp Glu Asp Thr Thr Val Thr Ile
  30                  35                  40                  45

 ccc tcg gcc gtg tac gtg gct caa ctt tac cac caa gtt agt aaa att      194
 Pro Ser Ala Val Tyr Val Ala Gln Leu Tyr His Gln Val Ser Lys Ile
                  50                  55                  60

 gag tgg gat tat gag tgt gag cca ggg atg gtc aaa ggc agg ggt atg      242
 Glu Trp Asp Tyr Glu Cys Glu Pro Gly Met Val Lys Gly Arg Gly Met
              65                  70                  75

 ttt gag tgc cac ggt gtg ccc aga ctc tgc tag gcaccaga gagacaagat      293
 Phe Glu Cys His Gly Val Pro Arg Leu Cys 
          80                  85

 acgagtgacg tggttctcct cccactgctg acggaggaat taacacaaaa agcagacaac    353

 actctagaac tggagagagg tccagattgc gacaggagcc acacaagagt gttgcaggct    413

 tcatggacgg acagaagcga cttttggtgc cgggacttta aaagataagg gcggccgcgt    473

 gtgctggttc atggcctgca gttcacagaa ctggttacaa cggagaggcc aggg          527




      <210> 441
      <211> 1776
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1776)

      <400> 441
  atg gga gaa tca ggc agc gcc cag aat tac agg aga ttt aga gag act      48
  Met Gly Glu Ser Gly Ser Ala Gln Asn Tyr Arg Arg Phe Arg Glu Thr
    1               5                  10                  15

 gta gcg cag cca cgt ggt gga aga aga ttt atg gac agc aaa agg aaa       96
 Val Ala Gln Pro Arg Gly Gly Arg Arg Phe Met Asp Ser Lys Arg Lys
              20                  25                  30

 gca agg gaa tct aaa tct cag gga agt tca tta cct gtt cca gtg tta      144
 Ala Arg Glu Ser Lys Ser Gln Gly Ser Ser Leu Pro Val Pro Val Leu
          35                  40                  45

 cag agg aga aag gtg atg gaa ctg gga tgt gtt ggt gga aat aac cca      192
 Gln Arg Arg Lys Val Met Glu Leu Gly Cys Val Gly Gly Asn Asn Pro
      50                  55                  60

 gat gaa gaa aag aat agc aca gcc aat tct ggg gtc tcc tct aca gac      240
 Asp Glu Glu Lys Asn Ser Thr Ala Asn Ser Gly Val Ser Ser Thr Asp
  65                  70                  75                  80

 atc ctg agc ttc ggg tac cag gga agt ttg ttg tca cac aca caa gac      288
 Ile Leu Ser Phe Gly Tyr Gln Gly Ser Leu Leu Ser His Thr Gln Asp
                  85                  90                  95

 cag gac aga aat act gaa gaa cta gac atg gct ggg gtg cag agc tta      336
 Gln Asp Arg Asn Thr Glu Glu Leu Asp Met Ala Gly Val Gln Ser Leu
             100                 105                 110

 gtg ccc agg ctg aga cat cag ctt tcc ttt ctg ccg tta aag ggt gct      384
 Val Pro Arg Leu Arg His Gln Leu Ser Phe Leu Pro Leu Lys Gly Ala
         115                 120                 125

 ggt tct tct tgt cct cca tca cct cca gaa atc agt gct ggt gaa atc      432
 Gly Ser Ser Cys Pro Pro Ser Pro Pro Glu Ile Ser Ala Gly Glu Ile
     130                 135                 140

 tac ttt gtg gaa ctg gtt aaa gaa gat ggg aca ctt gga ttc agc gta      480
 Tyr Phe Val Glu Leu Val Lys Glu Asp Gly Thr Leu Gly Phe Ser Val
 145                 150                 155                 160

 act gga tgc aat ctg gca aca tct att ata atg aaa aat gca cat atc      528
 Thr Gly Cys Asn Leu Ala Thr Ser Ile Ile Met Lys Asn Ala His Ile
                 165                 170                 175

 ctt tgg ccc atc aaa gca cac aag acg tgc cag gca caa gcc ttc agg      576
 Leu Trp Pro Ile Lys Ala His Lys Thr Cys Gln Ala Gln Ala Phe Arg
             180                 185                 190

 ccc ata gcc ata tcc acc tac gct ggt cac tac cta tat aga gat agt      624
 Pro Ile Ala Ile Ser Thr Tyr Ala Gly His Tyr Leu Tyr Arg Asp Ser
         195                 200                 205

 ggt gca tcc cac ggt ggc att aac acc agt gtg cca tat ggt ggt atc      672
 Gly Ala Ser His Gly Gly Ile Asn Thr Ser Val Pro Tyr Gly Gly Ile
     210                 215                 220

 tat gtg aaa tcc att gtt cct gga aga cca gct gcc aag gaa ggg cag      720
 Tyr Val Lys Ser Ile Val Pro Gly Arg Pro Ala Ala Lys Glu Gly Gln
 225                 230                 235                 240

 atc cta cag ggt gac cga ctc ctg cag gtg gat gga gtg att ctg tgc      768
 Ile Leu Gln Gly Asp Arg Leu Leu Gln Val Asp Gly Val Ile Leu Cys
                 245                 250                 255

 ggc ctc acc cac aag cag gct gtg cag tgc ctg aag ggt cct ggg cag      816
 Gly Leu Thr His Lys Gln Ala Val Gln Cys Leu Lys Gly Pro Gly Gln
             260                 265                 270

 gtt gca aga ctg gtc tta gag aga aga gtc ccc agg agt aca cag cag      864
 Val Ala Arg Leu Val Leu Glu Arg Arg Val Pro Arg Ser Thr Gln Gln
         275                 280                 285

 tgt cct tct gct aat gac agc atg gga gat gaa cgc acg gct gtt tcc      912
 Cys Pro Ser Ala Asn Asp Ser Met Gly Asp Glu Arg Thr Ala Val Ser
     290                 295                 300

 ttg gta aca gcc ttg cct ggc agg cct tcg agc tgt gtc tcg gtg aca      960
 Leu Val Thr Ala Leu Pro Gly Arg Pro Ser Ser Cys Val Ser Val Thr
 305                 310                 315                 320

 gat ggt cct aag ttt gaa gtc aaa cta aaa aag aat gcc aat ggt ttg     1008
 Asp Gly Pro Lys Phe Glu Val Lys Leu Lys Lys Asn Ala Asn Gly Leu
                 325                 330                 335

 gga ttc agt ttc gtg cag atg gag aaa gag agc tgc agc cat ctc aaa     1056
 Gly Phe Ser Phe Val Gln Met Glu Lys Glu Ser Cys Ser His Leu Lys
             340                 345                 350

 agt gat ctt gtg agg att aag agg ctc ttt ccg ggg cag cca gct gag     1104
 Ser Asp Leu Val Arg Ile Lys Arg Leu Phe Pro Gly Gln Pro Ala Glu
         355                 360                 365

 gag aat ggg gcc att gca gct ggt gac att atc ctg gcc gtg aat gga     1152
 Glu Asn Gly Ala Ile Ala Ala Gly Asp Ile Ile Leu Ala Val Asn Gly
     370                 375                 380

 agg tcc acg gaa ggc ctc atc ttc cag gag gtg ctg cat tta ctg aga     1200
 Arg Ser Thr Glu Gly Leu Ile Phe Gln Glu Val Leu His Leu Leu Arg
 385                 390                 395                 400

 ggg gcc cca cag gaa gtc acg ctc ctc ctt tgc cga ccc cct cca ggt     1248
 Gly Ala Pro Gln Glu Val Thr Leu Leu Leu Cys Arg Pro Pro Pro Gly
                 405                 410                 415

 gcg ctg cct gag atg gag cag gaa tgg cag aca cct gaa ctc tca gct     1296
 Ala Leu Pro Glu Met Glu Gln Glu Trp Gln Thr Pro Glu Leu Ser Ala
             420                 425                 430

 gac aaa gaa ttc acc agg gca aca tgt act gac tca tgt acc agc ccc     1344
 Asp Lys Glu Phe Thr Arg Ala Thr Cys Thr Asp Ser Cys Thr Ser Pro
         435                 440                 445

 atc ctg gat caa gag gac agc tgg agg gac agt gcc tcc cca gat gca     1392
 Ile Leu Asp Gln Glu Asp Ser Trp Arg Asp Ser Ala Ser Pro Asp Ala
     450                 455                 460

 ggg gaa ggc ctg ggt ctc agg cca gag tct tcc caa aag gcc atc aga     1440
 Gly Glu Gly Leu Gly Leu Arg Pro Glu Ser Ser Gln Lys Ala Ile Arg
 465                 470                 475                 480

 gag gca caa tgg ggc caa aac aga gag aga cct tgg gcc agt tcc ttg     1488
 Glu Ala Gln Trp Gly Gln Asn Arg Glu Arg Pro Trp Ala Ser Ser Leu
                 485                 490                 495

 aca cat tct cct gag tcc cac cct cat tta tgc aaa ctt cac caa gaa     1536
 Thr His Ser Pro Glu Ser His Pro His Leu Cys Lys Leu His Gln Glu
             500                 505                 510

 agg gat gaa tca aca ttg gcg acc tct ttg gaa aag gat gtg agg caa     1584
 Arg Asp Glu Ser Thr Leu Ala Thr Ser Leu Glu Lys Asp Val Arg Gln
         515                 520                 525

 aac tgc tat tca gtt tgt gat atc atg aga ctt gga agt gaa gct cag     1632
 Asn Cys Tyr Ser Val Cys Asp Ile Met Arg Leu Gly Ser Glu Ala Gln
     530                 535                 540

 ttt ggg aca gat gct tcc ggc tct act ggg gag gag gac gtg ctc tct     1680
 Phe Gly Thr Asp Ala Ser Gly Ser Thr Gly Glu Glu Asp Val Leu Ser
 545                 550                 555                 560

 ggg tat cta agg gtt tgt agc tat tgg ggt gca cca gag cca att tta     1728
 Gly Tyr Leu Arg Val Cys Ser Tyr Trp Gly Ala Pro Glu Pro Ile Leu
                 565                 570                 575

 aga gaa aga ggc aat gca gga aag gag aag gag agc agc agc aca taa     1776
 Arg Glu Arg Gly Asn Ala Gly Lys Glu Lys Glu Ser Ser Ser Thr 
             580                 585                 590





      <210> 442
      <211> 441
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(441)

      <400> 442
  atg acc ctg aca aaa ggt tcc ttc acc tac tcc agt ggg gag gaa tat      48
  Met Thr Leu Thr Lys Gly Ser Phe Thr Tyr Ser Ser Gly Glu Glu Tyr
    1               5                  10                  15

 cgt ggc gag tgg aag gag ggc cgc agg cat ggt ttt ggt caa ctg atg       96
 Arg Gly Glu Trp Lys Glu Gly Arg Arg His Gly Phe Gly Gln Leu Met
              20                  25                  30

 ttt gca gat ggt ggc acc tac ctg ggt cat ttt gag aat ggg ctc ttt      144
 Phe Ala Asp Gly Gly Thr Tyr Leu Gly His Phe Glu Asn Gly Leu Phe
          35                  40                  45

 aat ggc ttt ggg gta ttg acc ttc tca gat ggt tca agg tat gag ggg      192
 Asn Gly Phe Gly Val Leu Thr Phe Ser Asp Gly Ser Arg Tyr Glu Gly
      50                  55                  60

 gag ttt gcc cag ggc aag ttt aat ggc gtc gga gtc ttc att cga tat      240
 Glu Phe Ala Gln Gly Lys Phe Asn Gly Val Gly Val Phe Ile Arg Tyr
  65                  70                  75                  80

 gac aac atg acc ttt gag ggg gaa ttt aaa aat ggc aga gta gat ggt      288
 Asp Asn Met Thr Phe Glu Gly Glu Phe Lys Asn Gly Arg Val Asp Gly
                  85                  90                  95

 ttt ggc ctg ctg act ttc ccc gat ggt tct cat gga atc ccc cgc aat      336
 Phe Gly Leu Leu Thr Phe Pro Asp Gly Ser His Gly Ile Pro Arg Asn
             100                 105                 110

 gaa ggt ctc ttt gag aac aac aag ctg ctg cga cgt gag aag tgt tct      384
 Glu Gly Leu Phe Glu Asn Asn Lys Leu Leu Arg Arg Glu Lys Cys Ser
         115                 120                 125

 gcc att gtt cag cgg gcc cag agc gcc tcc aag tca gcc aga aat ctc      432
 Ala Ile Val Gln Arg Ala Gln Ser Ala Ser Lys Ser Ala Arg Asn Leu
     130                 135                 140

 act gcc tga                                                          441
 Thr Ala 
 145





      <210> 443
      <211> 735
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(735)

      <400> 443
  atg cat gcg gct aga cat ggg tgg gat gtg gaa aaa gat gca cca ctc      48
  Met His Ala Ala Arg His Gly Trp Asp Val Glu Lys Asp Ala Pro Leu
    1               5                  10                  15

 ttt aga aac tgg gca atc cat aca gga aag cat caa cca gga gta gat       96
 Phe Arg Asn Trp Ala Ile His Thr Gly Lys His Gln Pro Gly Val Asp
              20                  25                  30

 aaa cct gat ccc aaa aca tgg aag gcg aat ttc aga tgc gcc atg aat      144
 Lys Pro Asp Pro Lys Thr Trp Lys Ala Asn Phe Arg Cys Ala Met Asn
          35                  40                  45

 tcc ttg cct gat att gaa gaa gtc aag gat aaa agc ata aag aaa gga      192
 Ser Leu Pro Asp Ile Glu Glu Val Lys Asp Lys Ser Ile Lys Lys Gly
      50                  55                  60

 aat aat gcc ttc agg gtc tac cga atg ctg ccc cta tca gaa cgg cct      240
 Asn Asn Ala Phe Arg Val Tyr Arg Met Leu Pro Leu Ser Glu Arg Pro
  65                  70                  75                  80

 tct aag aaa gga aag aaa cca aag aca gaa aaa gaa gac aaa gtt aag      288
 Ser Lys Lys Gly Lys Lys Pro Lys Thr Glu Lys Glu Asp Lys Val Lys
                  85                  90                  95

 cac atc aag caa gaa cca gtt gag tca tct ctg ggg ctt agt aat gga      336
 His Ile Lys Gln Glu Pro Val Glu Ser Ser Leu Gly Leu Ser Asn Gly
             100                 105                 110

 gta agt gat ctt tct cct gag tat gcg gtc ctg act tca act ata aaa      384
 Val Ser Asp Leu Ser Pro Glu Tyr Ala Val Leu Thr Ser Thr Ile Lys
         115                 120                 125

 aat gaa gtg gat agt acg gtg aac atc ata gtt gta gga cag tcc cat      432
 Asn Glu Val Asp Ser Thr Val Asn Ile Ile Val Val Gly Gln Ser His
     130                 135                 140

 ctg gac agc aac att gag aat caa gag att gtc acc aat ccg cca gac      480
 Leu Asp Ser Asn Ile Glu Asn Gln Glu Ile Val Thr Asn Pro Pro Asp
 145                 150                 155                 160

 att tgc caa gtt gta gag gtg acc act gag agc gac gag cag ccg gtc      528
 Ile Cys Gln Val Val Glu Val Thr Thr Glu Ser Asp Glu Gln Pro Val
                 165                 170                 175

 act tcc aac aaa ccg gac ctc cag gtc acc atc aaa gag gag agc aat      576
 Thr Ser Asn Lys Pro Asp Leu Gln Val Thr Ile Lys Glu Glu Ser Asn
             180                 185                 190

 ccg gtg cct tac aac agc tcc tgg ccc cct ttt caa gac ctc ccc ctt      624
 Pro Val Pro Tyr Asn Ser Ser Trp Pro Pro Phe Gln Asp Leu Pro Leu
         195                 200                 205

 tct tcc tcc atg acc cca gca tcc agc agc agt cgg cca gac cgg gag      672
 Ser Ser Ser Met Thr Pro Ala Ser Ser Ser Ser Arg Pro Asp Arg Glu
     210                 215                 220

 acc cgg gcc agc gtc atc aag aaa aca tcg gat atc acc cag gcc cgc      720
 Thr Arg Ala Ser Val Ile Lys Lys Thr Ser Asp Ile Thr Gln Ala Arg
 225                 230                 235                 240

 gtc aag agc tgt taa                                                  735
 Val Lys Ser Cys 






      <210> 444
      <211> 501
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(501)

      <400> 444
  atg gga aga tgc cac ctg ggg ctg ctg ctc tcc agg tac atg gat gct      48
  Met Gly Arg Cys His Leu Gly Leu Leu Leu Ser Arg Tyr Met Asp Ala
    1               5                  10                  15

 act gtt tct ggg agt cac aga agg ctc acg ttt gac agg aaa aga atg       96
 Thr Val Ser Gly Ser His Arg Arg Leu Thr Phe Asp Arg Lys Arg Met
              20                  25                  30

 gta tgt aag ttc cag gag cac agg gtt ggg ttc cag ggt cag gac aag      144
 Val Cys Lys Phe Gln Glu His Arg Val Gly Phe Gln Gly Gln Asp Lys
          35                  40                  45

 aag cag ggc act cag aag agc aaa agg gac cga acg ctg cag ccc cgt      192
 Lys Gln Gly Thr Gln Lys Ser Lys Arg Asp Arg Thr Leu Gln Pro Arg
      50                  55                  60

 tat gtt ccc gac cct cag agg gat aga ccc ttc cct gct gcg gct ttt      240
 Tyr Val Pro Asp Pro Gln Arg Asp Arg Pro Phe Pro Ala Ala Ala Phe
  65                  70                  75                  80

 agc tcc cac cag cct tcc agc aat aca cct atc aaa atg tta cct gtt      288
 Ser Ser His Gln Pro Ser Ser Asn Thr Pro Ile Lys Met Leu Pro Val
                  85                  90                  95

 agg tcc aaa agc ctg gcc cat ggc tgc tca gaa tca aga gcg ttt gtg      336
 Arg Ser Lys Ser Leu Ala His Gly Cys Ser Glu Ser Arg Ala Phe Val
             100                 105                 110

 gga gct cta tta aaa act tcc tgc aag cag cag gaa ttc tac tgc atg      384
 Gly Ala Leu Leu Lys Thr Ser Cys Lys Gln Gln Glu Phe Tyr Cys Met
         115                 120                 125

 gat gtt cac agc acg aat ccc cac aaa cag ggc aga act tct cag ggt      432
 Asp Val His Ser Thr Asn Pro His Lys Gln Gly Arg Thr Ser Gln Gly
     130                 135                 140

 tgt aaa atg aag ctg aag ctg ctg cca gca ctg ctc tta tca caa gtg      480
 Cys Lys Met Lys Leu Lys Leu Leu Pro Ala Leu Leu Leu Ser Gln Val
 145                 150                 155                 160

 gca ggc cct atg ctg gac tga                                          501
 Ala Gly Pro Met Leu Asp 
                 165





      <210> 445
      <211> 2559
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2559)

      <400> 445
  atg tat gtg ata ttt atg tct ctt aca ggg aca gga cca gat ggt aga      48
  Met Tyr Val Ile Phe Met Ser Leu Thr Gly Thr Gly Pro Asp Gly Arg
    1               5                  10                  15

 atc acc aag aag gat atc gac tct ttt gtg cct agt aaa gtt gct cct       96
 Ile Thr Lys Lys Asp Ile Asp Ser Phe Val Pro Ser Lys Val Ala Pro
              20                  25                  30

 gct ccg gca gct gtt gtg cct ccc aca ggt cct gga atg gca cca gtt      144
 Ala Pro Ala Ala Val Val Pro Pro Thr Gly Pro Gly Met Ala Pro Val
          35                  40                  45

 cct aca ggt gtc ttc aca gat atc cca atc agc aac att cgt cgg gtt      192
 Pro Thr Gly Val Phe Thr Asp Ile Pro Ile Ser Asn Ile Arg Arg Val
      50                  55                  60

 att gca cag cga tta atg caa tca aag caa acc ata cct cat tat tac      240
 Ile Ala Gln Arg Leu Met Gln Ser Lys Gln Thr Ile Pro His Tyr Tyr
  65                  70                  75                  80

 ctt tct atc gat gta aat atg gga gaa gtt ttg ttg gta cgg aaa gaa      288
 Leu Ser Ile Asp Val Asn Met Gly Glu Val Leu Leu Val Arg Lys Glu
                  85                  90                  95

 ctt aat aag gat gcc ttg cag cag aga ttg act cag cag gac aca tct      336
 Leu Asn Lys Asp Ala Leu Gln Gln Arg Leu Thr Gln Gln Asp Thr Ser
             100                 105                 110

 gtt ctt cag ctc aaa caa gag cta ctg agg gca aat atg gac aaa gat      384
 Val Leu Gln Leu Lys Gln Glu Leu Leu Arg Ala Asn Met Asp Lys Asp
         115                 120                 125

 gag ctg cac aac cag aat gtg gat ctg cag agg aag cta gat gag agg      432
 Glu Leu His Asn Gln Asn Val Asp Leu Gln Arg Lys Leu Asp Glu Arg
     130                 135                 140

 aac cgg ctc ttg gga gaa tat aaa aaa gag ctg ggg cag aag gat cgc      480
 Asn Arg Leu Leu Gly Glu Tyr Lys Lys Glu Leu Gly Gln Lys Asp Arg
 145                 150                 155                 160

 ctt ctt cag cag cac cag gcc aag tta gaa gaa gca ctc cgg aaa ctc      528
 Leu Leu Gln Gln His Gln Ala Lys Leu Glu Glu Ala Leu Arg Lys Leu
                 165                 170                 175

 tct gat gtc agt tac cac cag aat cgt cat cat cta ccc agt cac ata      576
 Ser Asp Val Ser Tyr His Gln Asn Arg His His Leu Pro Ser His Ile
             180                 185                 190

 ggt ggt tac aca gtt gac ctt gaa caa cag gaa tct caa ctg tgc agg      624
 Gly Gly Tyr Thr Val Asp Leu Glu Gln Gln Glu Ser Gln Leu Cys Arg
         195                 200                 205

 tcc act tat cct cag att ttc ttc cac ctc tgc cac ctc cca gac cga      672
 Ser Thr Tyr Pro Gln Ile Phe Phe His Leu Cys His Leu Pro Asp Arg
     210                 215                 220

 cag gca gat ctc tct ccc gga ctg agg ccg gag gct gag ccg ggg cgg      720
 Gln Ala Asp Leu Ser Pro Gly Leu Arg Pro Glu Ala Glu Pro Gly Arg
 225                 230                 235                 240

 aat tcg gac agc ccg gtt gac ctg ggc att ccc cgc tca cgc tcc tct      768
 Asn Ser Asp Ser Pro Val Asp Leu Gly Ile Pro Arg Ser Arg Ser Ser
                 245                 250                 255

 agg acg aac ccc ggg gtt ccc cgg acc caa tta gat gtt gta ccc agg      816
 Arg Thr Asn Pro Gly Val Pro Arg Thr Gln Leu Asp Val Val Pro Arg
             260                 265                 270

 ctg gtt acc ctg gta aca ggc gtc gcg gtt tgt caa gga act gag aga      864
 Leu Val Thr Leu Val Thr Gly Val Ala Val Cys Gln Gly Thr Glu Arg
         275                 280                 285

 aga gat gat cta gct cag agt gac cct gag ggc tat gag aag ttt att      912
 Arg Asp Asp Leu Ala Gln Ser Asp Pro Glu Gly Tyr Glu Lys Phe Ile
     290                 295                 300

 cag cag cag ctg aaa gaa ggg aaa cag ctc tgt gct gcc cca gaa cca      960
 Gln Gln Gln Leu Lys Glu Gly Lys Gln Leu Cys Ala Ala Pro Glu Pro
 305                 310                 315                 320

 cag ctt tgt cta cag acc agg att ctg aaa cca aaa gaa aaa ata ctt     1008
 Gln Leu Cys Leu Gln Thr Arg Ile Leu Lys Pro Lys Glu Lys Ile Leu
                 325                 330                 335

 ttt atc aac ctg tgt cag tgg aca agg atc cca gct ccc caa tca acc     1056
 Phe Ile Asn Leu Cys Gln Trp Thr Arg Ile Pro Ala Pro Gln Ser Thr
             340                 345                 350

 act cat cca gta cct cta act gtt ggc aaa cca gaa gat aca act gag     1104
 Thr His Pro Val Pro Leu Thr Val Gly Lys Pro Glu Asp Thr Thr Glu
         355                 360                 365

 ata tca gat gct tac aca gtc att gat gtt gcc tac aat cct gat gtt     1152
 Ile Ser Asp Ala Tyr Thr Val Ile Asp Val Ala Tyr Asn Pro Asp Val
     370                 375                 380

 ctt cat gca gca gaa aag gac caa gtg aaa aaa aat cag tta att cag     1200
 Leu His Ala Ala Glu Lys Asp Gln Val Lys Lys Asn Gln Leu Ile Gln
 385                 390                 395                 400

 atg gcc atg aaa tgc att gag gag aaa ttc cag ttc acc ctc tca cac     1248
 Met Ala Met Lys Cys Ile Glu Glu Lys Phe Gln Phe Thr Leu Ser His
                 405                 410                 415

 tct tac cat att acc aaa ttt aga ata aaa gga agc att caa aga atg     1296
 Ser Tyr His Ile Thr Lys Phe Arg Ile Lys Gly Ser Ile Gln Arg Met
             420                 425                 430

 aaa caa aat ctg atg gga atc caa act gat tcc ata cat tta aga gaa     1344
 Lys Gln Asn Leu Met Gly Ile Gln Thr Asp Ser Ile His Leu Arg Glu
         435                 440                 445

 aaa atg aga agg gaa cta act ctt gga cag ata cga agc agt act atg     1392
 Lys Met Arg Arg Glu Leu Thr Leu Gly Gln Ile Arg Ser Ser Thr Met
     450                 455                 460

 agc aat cca gat cac ttt cct caa ctg tta ctg cca aaa gac caa gtt     1440
 Ser Asn Pro Asp His Phe Pro Gln Leu Leu Leu Pro Lys Asp Gln Val
 465                 470                 475                 480

 tca ggc aaa gca gtg tgt ctg ata gaa gag att tcc agt act gaa atc     1488
 Ser Gly Lys Ala Val Cys Leu Ile Glu Glu Ile Ser Ser Thr Glu Ile
                 485                 490                 495

 cag gtg gag atg aag atg cca gcc tat gaa cta aaa att gtg cat gat     1536
 Gln Val Glu Met Lys Met Pro Ala Tyr Glu Leu Lys Ile Val His Asp
             500                 505                 510

 cac agt gag aaa cct ctg aaa att gag ttg aaa gtt gaa tta cct ggt     1584
 His Ser Glu Lys Pro Leu Lys Ile Glu Leu Lys Val Glu Leu Pro Gly
         515                 520                 525

 att aat tct gtc tct ctc tgt gac ctt agt gtt tct gag tct cca gtg     1632
 Ile Asn Ser Val Ser Leu Cys Asp Leu Ser Val Ser Glu Ser Pro Val
     530                 535                 540

 cca gat agt cca cag ctg tcc tct ctt gga aaa tca gat tca tct ttc     1680
 Pro Asp Ser Pro Gln Leu Ser Ser Leu Gly Lys Ser Asp Ser Ser Phe
 545                 550                 555                 560

 tct gaa att tcc gga cta ttt tat aaa gat gaa gcc ttg gag aaa gat     1728
 Ser Glu Ile Ser Gly Leu Phe Tyr Lys Asp Glu Ala Leu Glu Lys Asp
                 565                 570                 575

 tta aat ggc ccc tct gga aca ctc ctg ccc cgt agt gcc cct cgt ccc     1776
 Leu Asn Gly Pro Ser Gly Thr Leu Leu Pro Arg Ser Ala Pro Arg Pro
             580                 585                 590

 cgc tcc gta gag aaa gag cgt gcg tgc cgc gca ttt ctg gcc tgg gga     1824
 Arg Ser Val Glu Lys Glu Arg Ala Cys Arg Ala Phe Leu Ala Trp Gly
         595                 600                 605

 gcg ggt gga gta aac ctg cgg gaa cca ttt tac gac aac gtg cgg ctg     1872
 Ala Gly Gly Val Asn Leu Arg Glu Pro Phe Tyr Asp Asn Val Arg Leu
     610                 615                 620

 tgc ggt gtg gct gac ggc aac gcc gct gct ctt gga gag gtt cca ttg     1920
 Cys Gly Val Ala Asp Gly Asn Ala Ala Ala Leu Gly Glu Val Pro Leu
 625                 630                 635                 640

 cct tct ctt tcc ccc aca atg cag gca ggc acc ata gcc cgt tgg gaa     1968
 Pro Ser Leu Ser Pro Thr Met Gln Ala Gly Thr Ile Ala Arg Trp Glu
                 645                 650                 655

 aaa aaa gag ggg gac aaa atc aat gaa ggt gac cta att gca gag gtt     2016
 Lys Lys Glu Gly Asp Lys Ile Asn Glu Gly Asp Leu Ile Ala Glu Val
             660                 665                 670

 gaa act gat aaa gcc act gtt gga ttt gag agc ctg gag gag tgt tat     2064
 Glu Thr Asp Lys Ala Thr Val Gly Phe Glu Ser Leu Glu Glu Cys Tyr
         675                 680                 685

 atg gca aag ata ctt gtt gct gaa ggt acc agg gat gtt ccc atc gga     2112
 Met Ala Lys Ile Leu Val Ala Glu Gly Thr Arg Asp Val Pro Ile Gly
     690                 695                 700

 gcg atc atc tgt atc aca gtt ggc aag cct gag gat att gag gcc ttt     2160
 Ala Ile Ile Cys Ile Thr Val Gly Lys Pro Glu Asp Ile Glu Ala Phe
 705                 710                 715                 720

 aaa aat tat aca ctg gat tcc tca gca gca cct acc cca caa gcg gcc     2208
 Lys Asn Tyr Thr Leu Asp Ser Ser Ala Ala Pro Thr Pro Gln Ala Ala
                 725                 730                 735

 cca gca cca acc cct gct gcc act gct tcg cca cct aca cct tct gct     2256
 Pro Ala Pro Thr Pro Ala Ala Thr Ala Ser Pro Pro Thr Pro Ser Ala
             740                 745                 750

 cag gct cct ggt agc tca tat ccc cct cac atg cag ctt gct gag ccc     2304
 Gln Ala Pro Gly Ser Ser Tyr Pro Pro His Met Gln Leu Ala Glu Pro
         755                 760                 765

 ttt gct ccc ctg gcg act gcc tgg aca gtc agc aag gaa ttg tct ccc     2352
 Phe Ala Pro Leu Ala Thr Ala Trp Thr Val Ser Lys Glu Leu Ser Pro
     770                 775                 780

 agt gca ttt tgc cct cct ggc tgc caa cgc tgg ctg cta aag tgg ctg     2400
 Ser Ala Phe Cys Pro Pro Gly Cys Gln Arg Trp Leu Leu Lys Trp Leu
 785                 790                 795                 800

 cca cct gct gca gtc tac aca gct tcg gga aga gga aag gaa cct cag     2448
 Pro Pro Ala Ala Val Tyr Thr Ala Ser Gly Arg Gly Lys Glu Pro Gln
                 805                 810                 815

 acc ttc cag atc gct tcc tct cgc aac aaa cta ttt gtc gca gat atg     2496
 Thr Phe Gln Ile Ala Ser Ser Arg Asn Lys Leu Phe Val Ala Asp Met
             820                 825                 830

 gga gag tat cac ttt aga gga gag gtt ctc aaa ctt ttt gct ctc atg     2544
 Gly Glu Tyr His Phe Arg Gly Glu Val Leu Lys Leu Phe Ala Leu Met
         835                 840                 845

 ttc cct tta cac taa                                                 2559
 Phe Pro Leu His 
     850





      <210> 446
      <211> 4948
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (63)..(4715)

      <400> 446
 agcaggctgc cagcgactcc tgctcttgct tctggatctg cagggcagtc ccagcaggac     60

 cc   atg gag tgt cct tcg tgc cag cat gtc tcc aag gag gaa acc ccc     107
      Met Glu Cys Pro Ser Cys Gln His Val Ser Lys Glu Glu Thr Pro
        1               5                  10                  15

 aag ttc tgc agc cag tgc gga gag agg ctg cct cct gca gcc ccc ata      155
 Lys Phe Cys Ser Gln Cys Gly Glu Arg Leu Pro Pro Ala Ala Pro Ile
                  20                  25                  30

 gca gat tct gag aac aat aac tcc aca atg gcg tcg gcc tcg gag ggt      203
 Ala Asp Ser Glu Asn Asn Asn Ser Thr Met Ala Ser Ala Ser Glu Gly
              35                  40                  45

 gaa atg gag tgt ggg cag gag ctg aag gag gaa ggg ggc ccg tgc ttg      251
 Glu Met Glu Cys Gly Gln Glu Leu Lys Glu Glu Gly Gly Pro Cys Leu
          50                  55                  60

 ttc ccg ggc tca gac agt tgg caa gaa aac ccc gag gag ccc tgt tcc      299
 Phe Pro Gly Ser Asp Ser Trp Gln Glu Asn Pro Glu Glu Pro Cys Ser
      65                  70                  75

 aaa gcc tcc tgg acc gtc caa gaa agc aaa aag aag aaa agg aag aag      347
 Lys Ala Ser Trp Thr Val Gln Glu Ser Lys Lys Lys Lys Arg Lys Lys
  80                  85                  90                  95

 aaa aag aag ggg aac aag tcc gct tcc tca gag ctg gct tcc ttg ccc      395
 Lys Lys Lys Gly Asn Lys Ser Ala Ser Ser Glu Leu Ala Ser Leu Pro
                 100                 105                 110

 ctt tct cct gcc agc ccc tgt cac ctg act ttg ctt tca aac ccg tgg      443
 Leu Ser Pro Ala Ser Pro Cys His Leu Thr Leu Leu Ser Asn Pro Trp
             115                 120                 125

 cct cag gac aca gcc ctg ccc cac agc caa gcc cag cag agt ggc ccc      491
 Pro Gln Asp Thr Ala Leu Pro His Ser Gln Ala Gln Gln Ser Gly Pro
         130                 135                 140

 act ggc cag ccg agc cag ccc cca ggc aca gcc acc acg cca ctg gag      539
 Thr Gly Gln Pro Ser Gln Pro Pro Gly Thr Ala Thr Thr Pro Leu Glu
     145                 150                 155

 ggt gac ggc ctc tcc gcg ccc acc gag gtt ggc gac agc ccc ctg cag      587
 Gly Asp Gly Leu Ser Ala Pro Thr Glu Val Gly Asp Ser Pro Leu Gln
 160                 165                 170                 175

 gcc cag gct ttg gga gag gca gga gtg gcc aca gga agt gag gct cag      635
 Ala Gln Ala Leu Gly Glu Ala Gly Val Ala Thr Gly Ser Glu Ala Gln
                 180                 185                 190

 agc agc ccg caa ttc cag gac cac acg gaa ggg gag gac cag gac gct      683
 Ser Ser Pro Gln Phe Gln Asp His Thr Glu Gly Glu Asp Gln Asp Ala
             195                 200                 205

 tcc atc ccc tct ggg ggc aga ggc ctg tcc cag gag ggg acc ggt ccc      731
 Ser Ile Pro Ser Gly Gly Arg Gly Leu Ser Gln Glu Gly Thr Gly Pro
         210                 215                 220

 ccc acc tct gct ggt gaa ggc cat tct agg act gaa gat gct gcc cag      779
 Pro Thr Ser Ala Gly Glu Gly His Ser Arg Thr Glu Asp Ala Ala Gln
     225                 230                 235

 gag ctc ctg ttg cct gag tca aaa gga ggc agc tct gag ccc ggg aca      827
 Glu Leu Leu Leu Pro Glu Ser Lys Gly Gly Ser Ser Glu Pro Gly Thr
 240                 245                 250                 255

 gaa ctg cag acc acc gag caa cag gca ggg gcc tca gcc tct atg gca      875
 Glu Leu Gln Thr Thr Glu Gln Gln Ala Gly Ala Ser Ala Ser Met Ala
                 260                 265                 270

 gtt gat gct gta gct gag cca gcc aat gca gtt aaa ggg gcc ggg aag      923
 Val Asp Ala Val Ala Glu Pro Ala Asn Ala Val Lys Gly Ala Gly Lys
             275                 280                 285

 gaa atg aaa gag aag acc cag aga atg aaa cag cca cca gca acc act      971
 Glu Met Lys Glu Lys Thr Gln Arg Met Lys Gln Pro Pro Ala Thr Thr
         290                 295                 300

 cct cct ttc aaa aca cac tgc cag gaa gct gag acc aag acc aag gac     1019
 Pro Pro Phe Lys Thr His Cys Gln Glu Ala Glu Thr Lys Thr Lys Asp
     305                 310                 315

 gag atg gct gct gct gaa gaa aaa gtc ggt aag aat gaa caa ggg gag     1067
 Glu Met Ala Ala Ala Glu Glu Lys Val Gly Lys Asn Glu Gln Gly Glu
 320                 325                 330                 335

 cct gaa gac ctc aag aag cca gag ggg aag aac aga agt gca gct gct     1115
 Pro Glu Asp Leu Lys Lys Pro Glu Gly Lys Asn Arg Ser Ala Ala Ala
                 340                 345                 350

 gtg aaa aac gag aag gag caa aaa aac cag gaa gca gat gtc cag gaa     1163
 Val Lys Asn Glu Lys Glu Gln Lys Asn Gln Glu Ala Asp Val Gln Glu
             355                 360                 365

 gtg aag gca agc acg ctg agc ccg ggt gga gga gtc acc gtg ttc ttc     1211
 Val Lys Ala Ser Thr Leu Ser Pro Gly Gly Gly Val Thr Val Phe Phe
         370                 375                 380

 cac gcc atc atc tct ctt cat ttc cca ttc aat cct gac ctc cat aaa     1259
 His Ala Ile Ile Ser Leu His Phe Pro Phe Asn Pro Asp Leu His Lys
     385                 390                 395

 gtc ttc atc aga gga gga gaa gaa ttt ggg gag tca aaa tgg gac agc     1307
 Val Phe Ile Arg Gly Gly Glu Glu Phe Gly Glu Ser Lys Trp Asp Ser
 400                 405                 410                 415

 aat atc tgt gag ctg cac tac acc aga gac ttg ggt cat gac cgc gtt     1355
 Asn Ile Cys Glu Leu His Tyr Thr Arg Asp Leu Gly His Asp Arg Val
                 420                 425                 430

 ctt gtt gaa ggc att gtc tgc att tcc aag aag cac cta gat aaa tac     1403
 Leu Val Glu Gly Ile Val Cys Ile Ser Lys Lys His Leu Asp Lys Tyr
             435                 440                 445

 att cct tac aag tac gtc att tat aat ggg gaa tct ttt gag tat gag     1451
 Ile Pro Tyr Lys Tyr Val Ile Tyr Asn Gly Glu Ser Phe Glu Tyr Glu
         450                 455                 460

 ttc att tac aag cac cag cag aag aag ggc gag tac gtc aac cgc tgt     1499
 Phe Ile Tyr Lys His Gln Gln Lys Lys Gly Glu Tyr Val Asn Arg Cys
     465                 470                 475

 ctg ttc ata aaa tct tca ctt ctg ggc tca gga gac tgg cat cag tac     1547
 Leu Phe Ile Lys Ser Ser Leu Leu Gly Ser Gly Asp Trp His Gln Tyr
 480                 485                 490                 495

 tat gac ata gtt tat atg aag cct cat ggg aga ctc cag aaa gtc atg     1595
 Tyr Asp Ile Val Tyr Met Lys Pro His Gly Arg Leu Gln Lys Val Met
                 500                 505                 510

 aac cac atc aca gac ggg ccg agg aag gac ctg gtg aag ggg aag cag     1643
 Asn His Ile Thr Asp Gly Pro Arg Lys Asp Leu Val Lys Gly Lys Gln
             515                 520                 525

 att gcc gct gcg ctc atg ctg gac agc acc ttc agc atc ctg cag acc     1691
 Ile Ala Ala Ala Leu Met Leu Asp Ser Thr Phe Ser Ile Leu Gln Thr
         530                 535                 540

 tgg gac acc atc aac ctg aac agc ttc ttc acc cag ttc gag cag ttt     1739
 Trp Asp Thr Ile Asn Leu Asn Ser Phe Phe Thr Gln Phe Glu Gln Phe
     545                 550                 555

 tgc ttt gtc ctg caa cag cct atg att tat gaa gga cag gca cag ctg     1787
 Cys Phe Val Leu Gln Gln Pro Met Ile Tyr Glu Gly Gln Ala Gln Leu
 560                 565                 570                 575

 tgg acc gat ttg cag tac agg gag aaa gag gtg aag aga tac ctg tgg     1835
 Trp Thr Asp Leu Gln Tyr Arg Glu Lys Glu Val Lys Arg Tyr Leu Trp
                 580                 585                 590

 caa cat ctg aaa aaa cac gtg gta cca ttg ccg gac gga aaa agc acg     1883
 Gln His Leu Lys Lys His Val Val Pro Leu Pro Asp Gly Lys Ser Thr
             595                 600                 605

 gac ttt ttg cct gtg gac tgc cca gtg agg agt aaa ctg aaa aca ggc     1931
 Asp Phe Leu Pro Val Asp Cys Pro Val Arg Ser Lys Leu Lys Thr Gly
         610                 615                 620

 ctg att gtc ctt ttt gta gtg gaa aaa att gag ctt tta tta gaa ggc     1979
 Leu Ile Val Leu Phe Val Val Glu Lys Ile Glu Leu Leu Leu Glu Gly
     625                 630                 635

 agc ctg gac tgg ttg tgt cac ctc cta acc tca gat gcc agc tca cca     2027
 Ser Leu Asp Trp Leu Cys His Leu Leu Thr Ser Asp Ala Ser Ser Pro
 640                 645                 650                 655

 gat gag ttt cac cgt gac cta agc cac atc ctt ggg ata cct cag agc     2075
 Asp Glu Phe His Arg Asp Leu Ser His Ile Leu Gly Ile Pro Gln Ser
                 660                 665                 670

 tgg cgg ctg tac ctg gtg aac ctg tgc caa aga tgc atg gac aca agg     2123
 Trp Arg Leu Tyr Leu Val Asn Leu Cys Gln Arg Cys Met Asp Thr Arg
             675                 680                 685

 acg tac acc tgg ctg ggc gcc ctg cct gtc ctg cac tgc tgt atg gag     2171
 Thr Tyr Thr Trp Leu Gly Ala Leu Pro Val Leu His Cys Cys Met Glu
         690                 695                 700

 ctg gcc ccg cgg cac aag gat gcc tgg aga cag cct gag gac acc tgg     2219
 Leu Ala Pro Arg His Lys Asp Ala Trp Arg Gln Pro Glu Asp Thr Trp
     705                 710                 715

 gcc gct ctg gag gga ctc tcc ttc tca ccg ttc cgg gaa caa atg cta     2267
 Ala Ala Leu Glu Gly Leu Ser Phe Ser Pro Phe Arg Glu Gln Met Leu
 720                 725                 730                 735

 gat acg agt tcc cta ctt cag ttt atg aga gag aag cag cat ttg ctg     2315
 Asp Thr Ser Ser Leu Leu Gln Phe Met Arg Glu Lys Gln His Leu Leu
                 740                 745                 750

 agc ata gac gag cct ctc ttc cgg tcc tgg ttt agt ctg cta cct ctg     2363
 Ser Ile Asp Glu Pro Leu Phe Arg Ser Trp Phe Ser Leu Leu Pro Leu
             755                 760                 765

 agt cac ctg gtt atg tat atg gaa aac ttc att gag cac ctg ggt cgt     2411
 Ser His Leu Val Met Tyr Met Glu Asn Phe Ile Glu His Leu Gly Arg
         770                 775                 780

 ttt cct gct cat atc ctg gac tgt ctt tca ggg att tac tac cgg ctt     2459
 Phe Pro Ala His Ile Leu Asp Cys Leu Ser Gly Ile Tyr Tyr Arg Leu
     785                 790                 795

 ccg gga ctt gag caa gtc ttg aat acg cag gat gtt cag gat gtt cag     2507
 Pro Gly Leu Glu Gln Val Leu Asn Thr Gln Asp Val Gln Asp Val Gln
 800                 805                 810                 815

 aac gtt cag aac att tta gaa atg ctg ttg cga ctc ctg gac act tac     2555
 Asn Val Gln Asn Ile Leu Glu Met Leu Leu Arg Leu Leu Asp Thr Tyr
                 820                 825                 830

 cgg gac aag att ccc gag gag gcc ttg tca cca tcc tac ctg act gtg     2603
 Arg Asp Lys Ile Pro Glu Glu Ala Leu Ser Pro Ser Tyr Leu Thr Val
             835                 840                 845

 tgt ctg aaa ctg cat gaa gcc atc tgc agc agc aca aag cta ctt aag     2651
 Cys Leu Lys Leu His Glu Ala Ile Cys Ser Ser Thr Lys Leu Leu Lys
         850                 855                 860

 ttt tac gag ctg cca gcc tta tct gcc gag att gtc tgc aga atg att     2699
 Phe Tyr Glu Leu Pro Ala Leu Ser Ala Glu Ile Val Cys Arg Met Ile
     865                 870                 875

 aga ctt cta tct ctg gtg gat tct gca gga cag aga gat gaa act gga     2747
 Arg Leu Leu Ser Leu Val Asp Ser Ala Gly Gln Arg Asp Glu Thr Gly
 880                 885                 890                 895

 aat aat tca gtc caa aca gtc ttc caa ggg acc ctt gct gct acg aaa     2795
 Asn Asn Ser Val Gln Thr Val Phe Gln Gly Thr Leu Ala Ala Thr Lys
                 900                 905                 910

 agg tgg ctc cga gaa gtt ttt aca aag aac atg ctc aca tct tca ggt     2843
 Arg Trp Leu Arg Glu Val Phe Thr Lys Asn Met Leu Thr Ser Ser Gly
             915                 920                 925

 gcc tca ttc aca tac gtc aag gaa att gag gtc tgg agg cgg ctg gtg     2891
 Ala Ser Phe Thr Tyr Val Lys Glu Ile Glu Val Trp Arg Arg Leu Val
         930                 935                 940

 gaa atc caa ttc ccc gcg gag cat ggc tgg aag gag tcg ttg ctg gga     2939
 Glu Ile Gln Phe Pro Ala Glu His Gly Trp Lys Glu Ser Leu Leu Gly
     945                 950                 955

 gac atg gaa tgg agg ctc aca aag gag gaa ccc ctc tcc cag atc act     2987
 Asp Met Glu Trp Arg Leu Thr Lys Glu Glu Pro Leu Ser Gln Ile Thr
 960                 965                 970                 975

 gcc tac tgc aat agt tgc tgg gac acc aaa ggc tta gag gac agt gtg     3035
 Ala Tyr Cys Asn Ser Cys Trp Asp Thr Lys Gly Leu Glu Asp Ser Val
                 980                 985                 990

 gcc aag acc ttc gag aaa tgc atc att gaa gcc gtg agc tca gcc tgc     3083
 Ala Lys Thr Phe Glu Lys Cys Ile Ile Glu Ala Val Ser Ser Ala Cys
             995                1000                1005

 cag tct cag acc agt atc ctt cag ggg ttc tct tac tct gat ttg cgg     3131
 Gln Ser Gln Thr Ser Ile Leu Gln Gly Phe Ser Tyr Ser Asp Leu Arg
        1010                1015                1020

 aaa ttt ggc atc gtc ttg tct gct gtg atc act aag tcc tgg cct agg     3179
 Lys Phe Gly Ile Val Leu Ser Ala Val Ile Thr Lys Ser Trp Pro Arg
    1025                1030                1035

 acc gcg gac aac ttc gat gac att tta aag cat ctg ctc acg ttg gca     3227
 Thr Ala Asp Asn Phe Asp Asp Ile Leu Lys His Leu Leu Thr Leu Ala
1040                1045                1050                1055

 gat gtc aag cac gtc ttc aga ttg tgt gga acc gac gag aaa ata cta     3275
 Asp Val Lys His Val Phe Arg Leu Cys Gly Thr Asp Glu Lys Ile Leu
                1060                1065                1070

 gca aat gtc aca gag gat gcc aag agg ctg ata gct gtt gcc gac tct     3323
 Ala Asn Val Thr Glu Asp Ala Lys Arg Leu Ile Ala Val Ala Asp Ser
            1075                1080                1085

 gtg ttg acg aaa gtt gtt ggt gac ctc cta agt ggc acg att tta gtt     3371
 Val Leu Thr Lys Val Val Gly Asp Leu Leu Ser Gly Thr Ile Leu Val
        1090                1095                1100

 gga caa ctg gag ctg att ata aag cac aag aat cag ttt ctt gac atc     3419
 Gly Gln Leu Glu Leu Ile Ile Lys His Lys Asn Gln Phe Leu Asp Ile
    1105                1110                1115

 tgg caa ctg agg gaa aaa agt ctt tca ccc cag gat gaa aaa tgt gct     3467
 Trp Gln Leu Arg Glu Lys Ser Leu Ser Pro Gln Asp Glu Lys Cys Ala
1120                1125                1130                1135

 gtg gag gaa gca ctg gat tgg aga agg gag gaa ctg tta ctt cta aag     3515
 Val Glu Glu Ala Leu Asp Trp Arg Arg Glu Glu Leu Leu Leu Leu Lys
                1140                1145                1150

 aaa gag aaa aga tgt gtt gat agt ctc ctg aag atg tgt ggg aac gtg     3563
 Lys Glu Lys Arg Cys Val Asp Ser Leu Leu Lys Met Cys Gly Asn Val
            1155                1160                1165

 aaa cat ctg ata caa gtg gac ttt gga gtg ctt gca gta aga cac tca     3611
 Lys His Leu Ile Gln Val Asp Phe Gly Val Leu Ala Val Arg His Ser
        1170                1175                1180

 caa gac ctc agc agt aaa aga tta aat gac acc atg aca gtg aga ctg     3659
 Gln Asp Leu Ser Ser Lys Arg Leu Asn Asp Thr Met Thr Val Arg Leu
    1185                1190                1195

 tcc acc tcc tcg aac tcg cag agg gca acg cat tac cac ctg agc tcc     3707
 Ser Thr Ser Ser Asn Ser Gln Arg Ala Thr His Tyr His Leu Ser Ser
1200                1205                1210                1215

 cag gtc caa gaa atg gct ggg aag ata gac ttg ctc aga gac agc cac     3755
 Gln Val Gln Glu Met Ala Gly Lys Ile Asp Leu Leu Arg Asp Ser His
                1220                1225                1230

 atc ttc cag ctc ttc tgg cgg gaa gcc gca gag ccg ctg agt gag cct     3803
 Ile Phe Gln Leu Phe Trp Arg Glu Ala Ala Glu Pro Leu Ser Glu Pro
            1235                1240                1245

 aag gag gac cag gaa gcc gca gag ttg ctg agt gag ccc gaa gaa gaa     3851
 Lys Glu Asp Gln Glu Ala Ala Glu Leu Leu Ser Glu Pro Glu Glu Glu
        1250                1255                1260

 tca gaa agg cac atc ctt gag ctt caa gag gtg tat gac tat ttg tat     3899
 Ser Glu Arg His Ile Leu Glu Leu Gln Glu Val Tyr Asp Tyr Leu Tyr
    1265                1270                1275

 cag cct tct tac aga aag ttc att aag ttg cac cag gat cta aag tca     3947
 Gln Pro Ser Tyr Arg Lys Phe Ile Lys Leu His Gln Asp Leu Lys Ser
1280                1285                1290                1295

 gga gag gtc acc ctt gca gag att gat gtc atc ttc aag gac ttt gtg     3995
 Gly Glu Val Thr Leu Ala Glu Ile Asp Val Ile Phe Lys Asp Phe Val
                1300                1305                1310

 aat aaa tac acg gac ctg gat tca gaa ctt aag atc atg tgc acc gtg     4043
 Asn Lys Tyr Thr Asp Leu Asp Ser Glu Leu Lys Ile Met Cys Thr Val
            1315                1320                1325

 gac cac cag ggc caa aga gat tgg atc aag gac cga gtg gaa cag atc     4091
 Asp His Gln Gly Gln Arg Asp Trp Ile Lys Asp Arg Val Glu Gln Ile
        1330                1335                1340

 aag gaa tac cat cac ctg cac cag gct gtc cac gca gcc aag gtc atc     4139
 Lys Glu Tyr His His Leu His Gln Ala Val His Ala Ala Lys Val Ile
    1345                1350                1355

 ttg cag gtc aaa gag agc ctg gga ctg aac ggt gac ttc agt gtt ctc     4187
 Leu Gln Val Lys Glu Ser Leu Gly Leu Asn Gly Asp Phe Ser Val Leu
1360                1365                1370                1375

 aac act tta cta aat ttt act gat aac ttc gac gac ttt cgc cgt gaa     4235
 Asn Thr Leu Leu Asn Phe Thr Asp Asn Phe Asp Asp Phe Arg Arg Glu
                1380                1385                1390

 aca ctg gac cag atc aac cag gag ctc atc cag gcc aaa aag ctg ctc     4283
 Thr Leu Asp Gln Ile Asn Gln Glu Leu Ile Gln Ala Lys Lys Leu Leu
            1395                1400                1405

 cag gac atc agc gag gcc cgg tgc aag ggg ctg cag gct ctg tcc ctg     4331
 Gln Asp Ile Ser Glu Ala Arg Cys Lys Gly Leu Gln Ala Leu Ser Leu
        1410                1415                1420

 aga aag gag ttc atc tgc tgg gtc cgg gag gct ctt gga ggc atc aat     4379
 Arg Lys Glu Phe Ile Cys Trp Val Arg Glu Ala Leu Gly Gly Ile Asn
    1425                1430                1435

 gag ctg aag gtg ttt gtg gac ctg gcc tcc atc tca gcg ggg gag aat     4427
 Glu Leu Lys Val Phe Val Asp Leu Ala Ser Ile Ser Ala Gly Glu Asn
1440                1445                1450                1455

 gac att gat gtg gac cgg gtg gcc tgc ttc cat gac gct gtg cag ggc     4475
 Asp Ile Asp Val Asp Arg Val Ala Cys Phe His Asp Ala Val Gln Gly
                1460                1465                1470

 tac gca tcc ctg cta ttt aag ctg gac ccc agc gtg gac ttc agt gca     4523
 Tyr Ala Ser Leu Leu Phe Lys Leu Asp Pro Ser Val Asp Phe Ser Ala
            1475                1480                1485

 ttc atg aag cat ctg aaa aag ctg tgg aag gct ctg gat aag gac cag     4571
 Phe Met Lys His Leu Lys Lys Leu Trp Lys Ala Leu Asp Lys Asp Gln
        1490                1495                1500

 tac ctg ccc agg aaa ctg gtg agt ctt att ctg tct cta atg cag att     4619
 Tyr Leu Pro Arg Lys Leu Val Ser Leu Ile Leu Ser Leu Met Gln Ile
    1505                1510                1515

 ttg ttg aat aga gca ttg ctt agc aac gtt agg gca gtg act gtg gaa     4667
 Leu Leu Asn Arg Ala Leu Leu Ser Asn Val Arg Ala Val Thr Val Glu
1520                1525                1530                1535

 atg gtg gca cac ctg tgt ggt agg ttt gta cac agc cgt ttt caa tga     4715
 Met Val Ala His Leu Cys Gly Arg Phe Val His Ser Arg Phe Gln 
                1540                1545                1550

 tatttaaaaa gcttttcttc ataaatggaa attcaccatc ttgttaccta gaaagcagga   4775

 tacaaaatta catgacacat agtaatctct aaggtgcaaa acacacgtgg aaaaaagaca   4835

 gaagggaaat atgctgaaac gttgccagga gttttctctg aatggttgta attgtcattt   4895

 tattctgtta ctttttgtta ttttctataa ttgatagaat tttttatcag aaa          4948




      <210> 447
      <211> 3862
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1509)..(3203)

      <400> 447
 gctacagtgt tctattagag cagcacaaac cgaagacagg agccttgctg tcattctcca     60

 accacctgca gacttgtatg tttaccccag tgtaccacat cgatgccttc actttccagg    120

 agtgccttca catggaaaca gctgcaaaga ctgacaccga gtctgcaata aggcacccag    180

 gagctcaact gaccgctgat ggcaagctga ttatacagga ccccttctgt cctgaaaagg    240

 acaattcata cttactgaaa tggacacaca ttctgtatgt ggattacctt tccggcttcc    300

 tgcacctcag caagcacgac aatccaacga cttacacaat gtctaatcta catatgactg    360

 tgcataacag caacttagaa accctgcggc tctcttcaag tggggggtat ccacgtgtga    420

 cccatcgagc aatggttttc catctttttc aaactctttt tgagaatctg attaaagcta    480

 tagacctgag ctctctgcct caggggaacc agcttcctgc caccactcct gggactcgtc    540

 tgcctccccc tggctgcatc ttctgtcctg aaactccagg tctggaagag gtgctccgcc    600

 tgcaggtcct ggagccctgc cagaggtttc tggagatgct ggttgaccca gcctcttggg    660

 gaagaggggc agggcgccag tgccagcaga cgacaggggc accggtgcta gcagggaaca    720

 gggcgggtct gctcatttcc ctcttcctgt caaagaggga ctttggcatg aaggatgtga    780

 agctgttttc tggggaggcc tctacctgct ggcagctcac agtgagggtc ctggaggcgc    840

 ggaacctgcg ctgggctgac ctgttgagtg aggccgaccc ttacgtgatc ctacagctgt    900

 cgaccgcacc tggaatgaag tttaagacca agacgctcac cgacaccagt catcctgtgt    960

 ggaatgaggc cttccgtttc cttatccaaa gtcaggtcaa gaatgttctg gagcttagca   1020

 tctatgatga ggactcagtc acggaggatg acatctgctt caaggttctc tatgacatct   1080

 cagaagtcct ccctggcaag ctgctccgga aaaccttctc ccagagtccc cagggagagg   1140

 aggagctgga tgtggagttc ctgatggaag aaacgtcaga tcgcccagaa aacctcatca   1200

 ccaacaaagt cattgtggcc cgagagctgt catgcctgga tgtgcatctg gacagcacag   1260

 ggagcaccgc tgtggttgca gatcaggaca agctggagct ggagctggtg ctgaaggggt   1320

 cctatgagga cacacagaca tccttcctgg gcacagcctc tgccttccgc ttccactaca   1380

 tggcagccct agagacagag ctgagcgggc gcctgaggag ctccagaagc aatggctgga   1440

 atggggacaa ctcagctggg tacctcactg tgcccctgag gcccttgacc attgggaagg   1500

 aggtgact atg gat gtt cct gct cca aat gcc cca gga gtg agg ctg cag    1550
          Met Asp Val Pro Ala Pro Asn Ala Pro Gly Val Arg Leu Gln
            1               5                  10

 ctc aag gca gag ggc tgc cct gag gag ctg gcc gtg cac ctg ggc ttc     1598
 Leu Lys Ala Glu Gly Cys Pro Glu Glu Leu Ala Val His Leu Gly Phe
  15                  20                  25                  30

 aat ctc tgt gca gag gag cag gcc ttc ctg agc agg agg aag cag gtg     1646
 Asn Leu Cys Ala Glu Glu Gln Ala Phe Leu Ser Arg Arg Lys Gln Val
                  35                  40                  45

 gtg gcc aag gcc ctg aag cag gcc ctg cag ctg gac aga gac ctg cag     1694
 Val Ala Lys Ala Leu Lys Gln Ala Leu Gln Leu Asp Arg Asp Leu Gln
              50                  55                  60

 gag gat gag gta ccc gtt gtg ggc atc atg gcc aca gga gga ggt gcc     1742
 Glu Asp Glu Val Pro Val Val Gly Ile Met Ala Thr Gly Gly Gly Ala
          65                  70                  75

 cgg gcc atg acc tca ctc tac ggc cac cta ttg gcc ttg cag aag ctg     1790
 Arg Ala Met Thr Ser Leu Tyr Gly His Leu Leu Ala Leu Gln Lys Leu
      80                  85                  90

 ggc ctc cta gac tgt gtg acc tac ttc agt ggc atc tct ggc tct acg     1838
 Gly Leu Leu Asp Cys Val Thr Tyr Phe Ser Gly Ile Ser Gly Ser Thr
  95                 100                 105                 110

 tgg aca atg gcc cac ctg tac ggg gac cct gag tgg tcg cag agg gac     1886
 Trp Thr Met Ala His Leu Tyr Gly Asp Pro Glu Trp Ser Gln Arg Asp
                 115                 120                 125

 ctg gag gga cct atc aga tac gcc cgg gag cac ctg gcc aag agc aag     1934
 Leu Glu Gly Pro Ile Arg Tyr Ala Arg Glu His Leu Ala Lys Ser Lys
             130                 135                 140

 ctg gag gtc ttt tcc cca gag cgc ctg gcg agc tac cgc cgg gag ctg     1982
 Leu Glu Val Phe Ser Pro Glu Arg Leu Ala Ser Tyr Arg Arg Glu Leu
         145                 150                 155

 gag ctg cgg gct gag cag ggc cac ccc acg acc ttt gtg gac ctg tgg     2030
 Glu Leu Arg Ala Glu Gln Gly His Pro Thr Thr Phe Val Asp Leu Trp
     160                 165                 170

 gcg cta gtg ctg gag tcc atg ctg cac ggc cag gtg atg gat cag aag     2078
 Ala Leu Val Leu Glu Ser Met Leu His Gly Gln Val Met Asp Gln Lys
 175                 180                 185                 190

 ctg tca gga cag aga gcc gcc ctg gaa cgg ggt cag aac cct ctg ccc     2126
 Leu Ser Gly Gln Arg Ala Ala Leu Glu Arg Gly Gln Asn Pro Leu Pro
                 195                 200                 205

 ctc tac ttg agc ctc aat gtc aaa gag agc aat ctg gag aca ctg gac     2174
 Leu Tyr Leu Ser Leu Asn Val Lys Glu Ser Asn Leu Glu Thr Leu Asp
             210                 215                 220

 ttc aag gag tgg gtt gag ttc tcc ccc tat gag gtc ggt ttc ctg aag     2222
 Phe Lys Glu Trp Val Glu Phe Ser Pro Tyr Glu Val Gly Phe Leu Lys
         225                 230                 235

 tac ggg gcc ttc gtc cct cct gag ctc ttc ggc tcc gag ttc ttc atg     2270
 Tyr Gly Ala Phe Val Pro Pro Glu Leu Phe Gly Ser Glu Phe Phe Met
     240                 245                 250

 gga cgg ctg atg agg agg atc ccg gag ccc cgg atc tgc ttt ctg gaa     2318
 Gly Arg Leu Met Arg Arg Ile Pro Glu Pro Arg Ile Cys Phe Leu Glu
 255                 260                 265                 270

 gcc atc tgg agc aac att ttc tcc ctg aac ctg ctg gat gcc tgg tat     2366
 Ala Ile Trp Ser Asn Ile Phe Ser Leu Asn Leu Leu Asp Ala Trp Tyr
                 275                 280                 285

 gac ctc acc agt tct ggg gag tcc tgg aaa cag cac atc aag gac aag     2414
 Asp Leu Thr Ser Ser Gly Glu Ser Trp Lys Gln His Ile Lys Asp Lys
             290                 295                 300

 acc agg agc tta gag aag gag ccc ctg acc acc tcg ggg acc tcc tcg     2462
 Thr Arg Ser Leu Glu Lys Glu Pro Leu Thr Thr Ser Gly Thr Ser Ser
         305                 310                 315

 cgg ctg gag gcc tcg tgg ctg cag cca ggc acg gcg ctg gcc cag gca     2510
 Arg Leu Glu Ala Ser Trp Leu Gln Pro Gly Thr Ala Leu Ala Gln Ala
     320                 325                 330

 ttt aaa ggc ttc ctg aca ggc agg ccc ctc cac cag cgc agc ccc aac     2558
 Phe Lys Gly Phe Leu Thr Gly Arg Pro Leu His Gln Arg Ser Pro Asn
 335                 340                 345                 350

 ttc ctc cag ggc ctc cag ctg cac cag gac tac tgt agc cac aaa gac     2606
 Phe Leu Gln Gly Leu Gln Leu His Gln Asp Tyr Cys Ser His Lys Asp
                 355                 360                 365

 ttc tcc acc tgg gca gac tac cag ctt gac tcc atg ccc agc cag ctg     2654
 Phe Ser Thr Trp Ala Asp Tyr Gln Leu Asp Ser Met Pro Ser Gln Leu
             370                 375                 380

 acc ccc aag gag ccc cgg ctc tgc ctg gtg gac gcc gcc tac ttc atc     2702
 Thr Pro Lys Glu Pro Arg Leu Cys Leu Val Asp Ala Ala Tyr Phe Ile
         385                 390                 395

 aac acc agc tct ccc tcc atg ttc cgg cca ggc cgc agg ctg gac ctc     2750
 Asn Thr Ser Ser Pro Ser Met Phe Arg Pro Gly Arg Arg Leu Asp Leu
     400                 405                 410

 atc ctc tcc ttc gac tac tcc cta tct gcg ccc ttc gag gca ctg cag     2798
 Ile Leu Ser Phe Asp Tyr Ser Leu Ser Ala Pro Phe Glu Ala Leu Gln
 415                 420                 425                 430

 cag acg gag ctg tac tgc cgg gcc cgg ggg ctg ccc ttc ccc cgg gtg     2846
 Gln Thr Glu Leu Tyr Cys Arg Ala Arg Gly Leu Pro Phe Pro Arg Val
                 435                 440                 445

 gaa ccc agc cct cag gac cag cac cag cca agg gaa tgc cac ctc ttc     2894
 Glu Pro Ser Pro Gln Asp Gln His Gln Pro Arg Glu Cys His Leu Phe
             450                 455                 460

 tca gac ccc gcc tgc ccc gag gcc ccg atc ctg ctg cac ttc ccg ctg     2942
 Ser Asp Pro Ala Cys Pro Glu Ala Pro Ile Leu Leu His Phe Pro Leu
         465                 470                 475

 gtc aat gcc tcc ttc aag gac cac tca gcc ccc ggt gtc cag cgc agc     2990
 Val Asn Ala Ser Phe Lys Asp His Ser Ala Pro Gly Val Gln Arg Ser
     480                 485                 490

 ccc gca gag ctc cag ggt ggc caa gtg gat ctc acc ggg gcc acc tgc     3038
 Pro Ala Glu Leu Gln Gly Gly Gln Val Asp Leu Thr Gly Ala Thr Cys
 495                 500                 505                 510

 ccc tac acc ctg tcc aac atg acc tac aag gag gaa gac ttc gag cgc     3086
 Pro Tyr Thr Leu Ser Asn Met Thr Tyr Lys Glu Glu Asp Phe Glu Arg
                 515                 520                 525

 ctg ctg cgg ctc agt gac tac aac gtg cag acc agc cag ggt gcc atc     3134
 Leu Leu Arg Leu Ser Asp Tyr Asn Val Gln Thr Ser Gln Gly Ala Ile
             530                 535                 540

 ctg cag gcc ctg agg acc gcg ctg aag cac cgg act cta gag gcg agg     3182
 Leu Gln Ala Leu Arg Thr Ala Leu Lys His Arg Thr Leu Glu Ala Arg
         545                 550                 555

 cct cca agg gca cag acc tga gg ttgctcagag gctgcaggac cctccagggc     3235
 Pro Pro Arg Ala Gln Thr 
     560

 ctgcgggcat aacctgatct gtagctgggc tcagccacag gccttcctgg ttggagttct   3295

 gggctctccc aggcctgggt ggcctctgta gctggtctca ctgcccagag ggaactgcac   3355

 acacagactt ctctcttacg ttcatggctg gcttgagatg agttgaaaat aacttcgcca   3415

 ggccagtgtg tagaacagct ggtccaacca gacagacttt cacaccacaa ttacttccat   3475

 gcctgagcag gatagatttg aagtgcaagc cggaggcagc agatcaggag tagggacagg   3535

 aaggacaggg gatgcctgac ctgacaggtg gcttcaggcc tcgggaatca caagacatcc   3595

 tgaacacatt gcctcctcat cttcttcctg ctcctccacc tcctcctctc cttgcccttc   3655

 tcctctttgc cctcctgctt tccgtatcca agtcttgtac ttgggtacat ttattcctgc   3715

 atgctgtagt cctgtagtga cgcatccgca ggttcccgag gacttgtggg cgcccgttga   3775

 gccccggcgc catgagaaga catgtgattg cctcctgcag cctcaacccg gagggcagcg   3835

 agggcctacc accatgatta ctggtgg                                       3862




      <210> 448
      <211> 666
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (205)..(489)

      <400> 448
 ccagccaata aaggtgtctg ttagtactgg cagaaacttt tatcctttgc aagctggcat     60

 atcagtgagg tctaattgcc agtcttcccc tttaacttta gccaatatat tcacacacag    120

 aatcccttct acaattaatt tttcataaac cttctacagc ttgtctttta accctccaaa    180

 ctttggcaag aaatccatat tctc   atg cct ttt acc aaa agt aca ttc tac     231
                              Met Pro Phe Thr Lys Ser Thr Phe Tyr
                                1               5

 ttt ttt tac atg aat cct ttt cac gac tta cac aga cct tct atg aca      279
 Phe Phe Tyr Met Asn Pro Phe His Asp Leu His Arg Pro Ser Met Thr
  10                  15                  20                  25

 tgc ctg gac ttt ctg act tgt cct aaa cat ccc tct tta aac aac cat      327
 Cys Leu Asp Phe Leu Thr Cys Pro Lys His Pro Ser Leu Asn Asn His
                  30                  35                  40

 tca ttt aac ttt agg gca aga att tac cat aca gga tcc tgt ctc ata      375
 Ser Phe Asn Phe Arg Ala Arg Ile Tyr His Thr Gly Ser Cys Leu Ile
              45                  50                  55

 caa aat tat tat tgc tac atc ctt ccc tac caa gaa tac atc ttc ata      423
 Gln Asn Tyr Tyr Cys Tyr Ile Leu Pro Tyr Gln Glu Tyr Ile Phe Ile
          60                  65                  70

 tac ata act ttc ttc acc tct ctc tcc cgt act tac tgg ttt ctt act      471
 Tyr Ile Thr Phe Phe Thr Ser Leu Ser Arg Thr Tyr Trp Phe Leu Thr
      75                  80                  85

 acc ttg ttt cat aaa taa cccttt tttttaagtc aacaacctga atcaaccttt      525
 Thr Leu Phe His Lys 
  90

 agacaacctc tgaactacac aaaatcattt ctttcttacc aatagcacat cttttttggc    585

 accttttgta tacagaatca tttgttaact aaaattctta tccttagtaa ccttaaattt    645

 tagtgaaacc ctaaaaagca g                                              666




      <210> 449
      <211> 2337
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2337)

      <400> 449
  atg cag caa gaa tca gag aga tgc aga gtt aga gcc aga agg cct gac      48
  Met Gln Gln Glu Ser Glu Arg Cys Arg Val Arg Ala Arg Arg Pro Asp
    1               5                  10                  15

 atg gca ctt tat gta cct aaa gct cgt agg ggt gca gta ctc ctt aag       96
 Met Ala Leu Tyr Val Pro Lys Ala Arg Arg Gly Ala Val Leu Leu Lys
              20                  25                  30

 aca ggt gat gaa gaa gaa agc tgt ggt tca cct aac tct gtg gtg aaa      144
 Thr Gly Asp Glu Glu Glu Ser Cys Gly Ser Pro Asn Ser Val Val Lys
          35                  40                  45

 gaa aag caa aaa gaa agt tct ctc tcc caa aaa gaa gtc ttt aaa gac      192
 Glu Lys Gln Lys Glu Ser Ser Leu Ser Gln Lys Glu Val Phe Lys Asp
      50                  55                  60

 aaa ccg gag gct cga aga cta aat atc aat cct gat aga aag gag cat      240
 Lys Pro Glu Ala Arg Arg Leu Asn Ile Asn Pro Asp Arg Lys Glu His
  65                  70                  75                  80

 aat tgt aga gaa gaa aag aaa tct tca aca aaa tta aga atg gac aca      288
 Asn Cys Arg Glu Glu Lys Lys Ser Ser Thr Lys Leu Arg Met Asp Thr
                  85                  90                  95

 tgc ctt caa aaa aca aat aga gtt tgt tct aag aga gga acc act gaa      336
 Cys Leu Gln Lys Thr Asn Arg Val Cys Ser Lys Arg Gly Thr Thr Glu
             100                 105                 110

 tcc aaa gaa gta tta tcc caa gga caa cag cag gga gcc cca aat gct      384
 Ser Lys Glu Val Leu Ser Gln Gly Gln Gln Gln Gly Ala Pro Asn Ala
         115                 120                 125

 ggg gtt ata act aat gca cct ttg cag aga cat ttt aaa cca aag aag      432
 Gly Val Ile Thr Asn Ala Pro Leu Gln Arg His Phe Lys Pro Lys Lys
     130                 135                 140

 gtg gag tgt ttg gaa gtt gaa act acg gat gtg aca gga cat gag agg      480
 Val Glu Cys Leu Glu Val Glu Thr Thr Asp Val Thr Gly His Glu Arg
 145                 150                 155                 160

 ata ctt ctt tca cag gcc tgt tta gaa atc agc gag gct caa gtt cca      528
 Ile Leu Leu Ser Gln Ala Cys Leu Glu Ile Ser Glu Ala Gln Val Pro
                 165                 170                 175

 agc aaa cca ttc caa aat gtg gaa ttc tgt gac ttc agt agg cat gaa      576
 Ser Lys Pro Phe Gln Asn Val Glu Phe Cys Asp Phe Ser Arg His Glu
             180                 185                 190

 cct gat ggg gaa gca ttt gaa gac aaa gat ttg gaa ggc aga att gaa      624
 Pro Asp Gly Glu Ala Phe Glu Asp Lys Asp Leu Glu Gly Arg Ile Glu
         195                 200                 205

 act gat acc aag gtt ttg gag ata cta tat gag ttt cct aga gtt ttt      672
 Thr Asp Thr Lys Val Leu Glu Ile Leu Tyr Glu Phe Pro Arg Val Phe
     210                 215                 220

 agt tct gtc atg aaa cct gag aat atg att gta cca ata aaa cta agc      720
 Ser Ser Val Met Lys Pro Glu Asn Met Ile Val Pro Ile Lys Leu Ser
 225                 230                 235                 240

 tct gat tct gaa att gta caa caa agc atg caa aca tca gat gga ata      768
 Ser Asp Ser Glu Ile Val Gln Gln Ser Met Gln Thr Ser Asp Gly Ile
                 245                 250                 255

 ttg aat ccc agc agc gga ggc atc acc act act tct gtt cct gga agt      816
 Leu Asn Pro Ser Ser Gly Gly Ile Thr Thr Thr Ser Val Pro Gly Ser
             260                 265                 270

 cca gat ggt gtc ttt gat caa act tgc gta gat ttt gaa gtt gag agt      864
 Pro Asp Gly Val Phe Asp Gln Thr Cys Val Asp Phe Glu Val Glu Ser
         275                 280                 285

 gta ggt ggt ata gcc aat agt aca ggt ttc atc tta gat caa aaa gat      912
 Val Gly Gly Ile Ala Asn Ser Thr Gly Phe Ile Leu Asp Gln Lys Asp
     290                 295                 300

 aca gat tcc att cct gca act atg ggt cac atc tct ctg tca gag agc      960
 Thr Asp Ser Ile Pro Ala Thr Met Gly His Ile Ser Leu Ser Glu Ser
 305                 310                 315                 320

 aca aat gac act gtt agt cca gta atg att aga gaa tgt gag aag aat     1008
 Thr Asn Asp Thr Val Ser Pro Val Met Ile Arg Glu Cys Glu Lys Asn
                 325                 330                 335

 gac agc act gct gat gag tta cat gta aag cac gaa cct cct gat aca     1056
 Asp Ser Thr Ala Asp Glu Leu His Val Lys His Glu Pro Pro Asp Thr
             340                 345                 350

 gct gtc ctt gct cat gaa aca cat aga gat agt gga ttt aag aat gta     1104
 Ala Val Leu Ala His Glu Thr His Arg Asp Ser Gly Phe Lys Asn Val
         355                 360                 365

 ggt gac att acc aat aaa gca tgt atg atg gac act aca ggt atg tcc     1152
 Gly Asp Ile Thr Asn Lys Ala Cys Met Met Asp Thr Thr Gly Met Ser
     370                 375                 380

 tgt agt gat cat gta act gtt gat agc cct tat gta gtt gca gtt aga     1200
 Cys Ser Asp His Val Thr Val Asp Ser Pro Tyr Val Val Ala Val Arg
 385                 390                 395                 400

 ata gct gat gag acc tct att aat aca cga agt ttc tca aag ttt gta     1248
 Ile Ala Asp Glu Thr Ser Ile Asn Thr Arg Ser Phe Ser Lys Phe Val
                 405                 410                 415

 gga atg agt gca gat gca acc cct ctt cat gta gct aga agt ggg aat     1296
 Gly Met Ser Ala Asp Ala Thr Pro Leu His Val Ala Arg Ser Gly Asn
             420                 425                 430

 gac act gaa gat ttc agc aac cct tct gct tgc tca gat att tat ggt     1344
 Asp Thr Glu Asp Phe Ser Asn Pro Ser Ala Cys Ser Asp Ile Tyr Gly
         435                 440                 445

 gag agt att tca tct cat ttt aca gag tca aca gga aag ttg ata gag     1392
 Glu Ser Ile Ser Ser His Phe Thr Glu Ser Thr Gly Lys Leu Ile Glu
     450                 455                 460

 agc ttg tca gat tgt gct tcc tcc tta cct ata aaa aag att gct ggt     1440
 Ser Leu Ser Asp Cys Ala Ser Ser Leu Pro Ile Lys Lys Ile Ala Gly
 465                 470                 475                 480

 agt aat tat aac act ttt ttg gac tct gaa ctc agt atg tta aat ggg     1488
 Ser Asn Tyr Asn Thr Phe Leu Asp Ser Glu Leu Ser Met Leu Asn Gly
                 485                 490                 495

 aca aaa gtt ctt tca gac agt gcc gtg ggc att gac ctg ggt agt act     1536
 Thr Lys Val Leu Ser Asp Ser Ala Val Gly Ile Asp Leu Gly Ser Thr
             500                 505                 510

 ggt gat aca aca gaa gca ttg cac gaa cta aga act gcc gaa gag ttc     1584
 Gly Asp Thr Thr Glu Ala Leu His Glu Leu Arg Thr Ala Glu Glu Phe
         515                 520                 525

 aaa aca gaa gag caa gat gac tca ggg agt ata gaa ttt ggt gta tct     1632
 Lys Thr Glu Glu Gln Asp Asp Ser Gly Ser Ile Glu Phe Gly Val Ser
     530                 535                 540

 ttt cct gat agg gaa tca tca tct atg gaa aca tcc atc gaa cca aaa     1680
 Phe Pro Asp Arg Glu Ser Ser Ser Met Glu Thr Ser Ile Glu Pro Lys
 545                 550                 555                 560

 gca act gaa act tct cgc aca gag gga att act gcc att gag gag agc     1728
 Ala Thr Glu Thr Ser Arg Thr Glu Gly Ile Thr Ala Ile Glu Glu Ser
                 565                 570                 575

 tgg gag tct atg ttt aac gat gat ggt gac tgc ctg gat cca cgt ctt     1776
 Trp Glu Ser Met Phe Asn Asp Asp Gly Asp Cys Leu Asp Pro Arg Leu
             580                 585                 590

 cta caa gag tta tca ggg aat acc aag agc aga gag agc atc cag gaa     1824
 Leu Gln Glu Leu Ser Gly Asn Thr Lys Ser Arg Glu Ser Ile Gln Glu
         595                 600                 605

 cct aga tct gat tac tac aat cat gaa gtt cct gat att gac ctc agt     1872
 Pro Arg Ser Asp Tyr Tyr Asn His Glu Val Pro Asp Ile Asp Leu Ser
     610                 615                 620

 gat tgt gaa ttc cca cat gtc att gaa att tat gac ttt ccc caa gaa     1920
 Asp Cys Glu Phe Pro His Val Ile Glu Ile Tyr Asp Phe Pro Gln Glu
 625                 630                 635                 640

 ttt cgt act gaa gac ctt cta cgg gtt ttc tgc agt tat caa aag aaa     1968
 Phe Arg Thr Glu Asp Leu Leu Arg Val Phe Cys Ser Tyr Gln Lys Lys
                 645                 650                 655

 gga ttt gat att aaa tgg gtg gat gat aca cat gcc cta gga gta ttc     2016
 Gly Phe Asp Ile Lys Trp Val Asp Asp Thr His Ala Leu Gly Val Phe
             660                 665                 670

 tcc agt cca att aca gct cgt gat gcg ttg ggt att aaa cac acc atg     2064
 Ser Ser Pro Ile Thr Ala Arg Asp Ala Leu Gly Ile Lys His Thr Met
         675                 680                 685

 gtg aag att cgt ccc ttg tca cag gcc aca aga gca gcc aag gcc aaa     2112
 Val Lys Ile Arg Pro Leu Ser Gln Ala Thr Arg Ala Ala Lys Ala Lys
     690                 695                 700

 gct aga gct tat gct gag ttc ctc cag cca gca aag gag cgt cct gag     2160
 Ala Arg Ala Tyr Ala Glu Phe Leu Gln Pro Ala Lys Glu Arg Pro Glu
 705                 710                 715                 720

 act tca gca gcc cta gcc aga agg tta gtc atc agt gcc ctt ggg gtt     2208
 Thr Ser Ala Ala Leu Ala Arg Arg Leu Val Ile Ser Ala Leu Gly Val
                 725                 730                 735

 cga agt aag cag agc aaa acc gaa cga gaa gca gag ctc aag aaa ctg     2256
 Arg Ser Lys Gln Ser Lys Thr Glu Arg Glu Ala Glu Leu Lys Lys Leu
             740                 745                 750

 caa gaa gcc aga gag aga aag cgg ttg gaa gcc aag caa cgg gaa gac     2304
 Gln Glu Ala Arg Glu Arg Lys Arg Leu Glu Ala Lys Gln Arg Glu Asp
         755                 760                 765

 atc tgg gaa ggc aga gac cag tct aca gtt tga                         2337
 Ile Trp Glu Gly Arg Asp Gln Ser Thr Val 
     770                 775





      <210> 450
      <211> 1367
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (20)..(925)

      <400> 450
 ctcggccgag attgcggcg atg tcg cag ggg acg act ccc tgg ggg ccg acc      52
                      Met Ser Gln Gly Thr Thr Pro Trp Gly Pro Thr
                        1               5                  10

 ccg gca ggg ccg acc ccg gcg gga acc acg ccc gaa tcg gag aga gac      100
 Pro Ala Gly Pro Thr Pro Ala Gly Thr Thr Pro Glu Ser Glu Arg Asp
              15                  20                  25

 act gaa ttc cag gag cat gaa aag att ctg tct ccg gat ttt ctt tca      148
 Thr Glu Phe Gln Glu His Glu Lys Ile Leu Ser Pro Asp Phe Leu Ser
          30                  35                  40

 gtt gcc caa atc act gat ttg tta atg gag gac atc gat gga gtt caa      196
 Val Ala Gln Ile Thr Asp Leu Leu Met Glu Asp Ile Asp Gly Val Gln
      45                  50                  55

 gaa aaa ctg aga ata ttt ttg aat ttc aaa aac ctt gaa act tgt tta      244
 Glu Lys Leu Arg Ile Phe Leu Asn Phe Lys Asn Leu Glu Thr Cys Leu
  60                  65                  70                  75

 aag gat gcc att cta cta gat tat tat gta tct gga ttt ttg tgg gct      292
 Lys Asp Ala Ile Leu Leu Asp Tyr Tyr Val Ser Gly Phe Leu Trp Ala
                  80                  85                  90

 aga gga atg gat ttc tct att att cag tat tca aaa ttt atg act tta      340
 Arg Gly Met Asp Phe Ser Ile Ile Gln Tyr Ser Lys Phe Met Thr Leu
              95                 100                 105

 cta gct atg tca ctt caa aat ctt aaa aca cta cat atg tcc tta gag      388
 Leu Ala Met Ser Leu Gln Asn Leu Lys Thr Leu His Met Ser Leu Glu
         110                 115                 120

 gaa agc ata aaa tgg ctt gga gaa gtt atg gct gaa ata gga cca aca      436
 Glu Ser Ile Lys Trp Leu Gly Glu Val Met Ala Glu Ile Gly Pro Thr
     125                 130                 135

 cat tcg caa aag agt gag gac tgg aat atc ttt gat gta aaa caa gcc      484
 His Ser Gln Lys Ser Glu Asp Trp Asn Ile Phe Asp Val Lys Gln Ala
 140                 145                 150                 155

 aat gct atc att gat tac tta aaa atc agc tta ttt caa cac tac aag      532
 Asn Ala Ile Ile Asp Tyr Leu Lys Ile Ser Leu Phe Gln His Tyr Lys
                 160                 165                 170

 cta tac gag ttt atg ttc tac tct gcc agg gaa gaa att gtg ata gga      580
 Leu Tyr Glu Phe Met Phe Tyr Ser Ala Arg Glu Glu Ile Val Ile Gly
             175                 180                 185

 act gag caa gtg ata gag gtt gtc aag tct gca tgt ggc cct ttc cca      628
 Thr Glu Gln Val Ile Glu Val Val Lys Ser Ala Cys Gly Pro Phe Pro
         190                 195                 200

 aat cct ctg gaa gaa gga atc tca ttt gat att tat tca aca ttc ata      676
 Asn Pro Leu Glu Glu Gly Ile Ser Phe Asp Ile Tyr Ser Thr Phe Ile
     205                 210                 215

 gag ccc ccc aca ata ttg gat acg gaa atg aag agg ttg gat caa gaa      724
 Glu Pro Pro Thr Ile Leu Asp Thr Glu Met Lys Arg Leu Asp Gln Glu
 220                 225                 230                 235

 caa ggc cct gag gag tct cag cca gaa act gac acc tca gac atg gat      772
 Gln Gly Pro Glu Glu Ser Gln Pro Glu Thr Asp Thr Ser Asp Met Asp
                 240                 245                 250

 cct tta gtt ggt ttc acc att gaa gat gta aaa tca gtg ctg gat caa      820
 Pro Leu Val Gly Phe Thr Ile Glu Asp Val Lys Ser Val Leu Asp Gln
             255                 260                 265

 gtc aca gat gac att tta atc ggc att cag acc gag ata aac gaa aaa      868
 Val Thr Asp Asp Ile Leu Ile Gly Ile Gln Thr Glu Ile Asn Glu Lys
         270                 275                 280

 ctg caa ata cag gaa gag gcc ttt aat gca cga ata gaa aaa ttg aaa      916
 Leu Gln Ile Gln Glu Glu Ala Phe Asn Ala Arg Ile Glu Lys Leu Lys
     285                 290                 295

 aag gcc taa ggacttg gtacaaggag agtgatgcta aacttcacag aaacaaacaa      972
 Lys Ala 
 300

 aaccagccag aataacagac tctctggagc gtcgtgtctc catcacttag ttgtgaaagg   1032

 aaaaccaagc cccacttttt attttcctaa gtaattagaa aagtattggt cccaattttg   1092

 ctatctccca tcccataaca gcctctgaat ttattgcacc aagtgtaatg agaacatttt   1152

 gtatacaaga gtttgaaaaa ttatatataa aaatacaatt acttttatga tagtcctttg   1212

 acgttttgac taataaatcc tattcatctt caatcaaaaa aacaaaatat ggcactagat   1272

 ggcctcagcg ggggaacatt tgcagcagtc tacctccccg gaggggatag tacaggaatc   1332

 cgcgttcact gccctttgtc ttcgttgctc cggtt                              1367




      <210> 451
      <211> 434
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (134)..(310)

      <220>
      <221> misc_feature
      <222> (1)...(434)
      <223> n = a,t,c or g

      <400> 451
 tttcgtgccg cgggacgccg gcagggttgt ggcgcagcag tctccttcct gcgcgcgcgc     60

 ctgaagtcgg cgtgggcgtt tgaggaagct gggatacagc atttaatgaa aaatttatgc    120

 ttaagaagta aaa   atg gca ggc ttc cta gat aat ttt cgt tgg cca gaa     169
                  Met Ala Gly Phe Leu Asp Asn Phe Arg Trp Pro Glu
                    1               5                  10

 tgt gaa tgt att gac tgg agt gag aga aga aat gtt gtg gca tct gtt      217
 Cys Glu Cys Ile Asp Trp Ser Glu Arg Arg Asn Val Val Ala Ser Val
          15                  20                  25

 gtc gca ggt ata ttg gta agt gag aaa gac tgg ttg gtg aca tgt atc      265
 Val Ala Gly Ile Leu Val Ser Glu Lys Asp Trp Leu Val Thr Cys Ile
      30                  35                  40

 cct tac ctt ttg ccc tgg aaa tta atg ccg gtt cct ttg aac tga gaa      313
 Pro Tyr Leu Leu Pro Trp Lys Leu Met Pro Val Pro Leu Asn 
  45                  50                  55

 tggctttcca gaactattta tttcactgct gttttgtata gatgattatc agagttctag    373

 atactattgc caagcagaat atggtaggcc ctggattcat tntgactttg taaatgtgta    433

 c                                                                    434




      <210> 452
      <211> 633
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (44)..(367)

      <400> 452
 cgacgatttc gttgcttcca agacccaggg ggctgtcgcc cga  atg cag gaa gac      55
                                                  Met Gln Glu Asp
                                                    1

 cgt gat ggg agc tgc agc aca gtc ggg ggt gta ggt tat ggg ggt gag      103
 Arg Asp Gly Ser Cys Ser Thr Val Gly Gly Val Gly Tyr Gly Gly Glu
   5                  10                  15                  20

 tac ggt gcc ccg gag gcg cgg ctg atg tgt ctt cct ttc tct atg acc      151
 Tyr Gly Ala Pro Glu Ala Arg Leu Met Cys Leu Pro Phe Ser Met Thr
                  25                  30                  35

 ggg tgt gca acg gac ctc tgg tct gac cct agg agc cct tca gct ctg      199
 Gly Cys Ala Thr Asp Leu Trp Ser Asp Pro Arg Ser Pro Ser Ala Leu
              40                  45                  50

 ggg cca cct ggg ttc gac tgg gcc cca cgg gtg gtg gcc cag cgg gat      247
 Gly Pro Pro Gly Phe Asp Trp Ala Pro Arg Val Val Ala Gln Arg Asp
          55                  60                  65

 ggg ttg gag ccg gtg gcg gct act tgg ttg ggg ctg ccc ggg gat ggc      295
 Gly Leu Glu Pro Val Ala Ala Thr Trp Leu Gly Leu Pro Gly Asp Gly
      70                  75                  80

 gga gaa aat gcc atg gga tgg cgg aga aaa tgc cat gga atg gcc ttc      343
 Gly Glu Asn Ala Met Gly Trp Arg Arg Lys Cys His Gly Met Ala Phe
  85                  90                  95                 100

 ccc tcc gcc ggg gaa gct ccc tga gcgtttgtct tctggtttgg agctcccagc     397
 Pro Ser Ala Gly Glu Ala Pro 
                 105

 tttgagctag ctgctgagtg ggtttggttc atatctggtt cgcgcgcgtg tgtttataat    457

 tttgggatta gcagctcttt ctcctcacca gtacactgcc ttggtttgct tggtttgacc    517

 tcgcaggtgt gttttattta gcttccggag tatttccagt cgcagactgg tggtcactgc    577

 tctccactct acagatttgc ccagtttgtg gctgaggtga cctgctctct ttgaaa        633




      <210> 453
      <211> 2475
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (76)..(2472)

      <400> 453
 ctgtatttct aagaactctc ttttcccctg ctttctctgg attttggagc ccaccaaggt     60

 ctgggatctg ccgat atg ggg gat atg aag acc cct gat ttt gat gac ctc     111
                  Met Gly Asp Met Lys Thr Pro Asp Phe Asp Asp Leu
                    1               5                  10

 ctt gct gcc ttt gac atc cct gac att gat gcg aat gaa gcc atc cat      159
 Leu Ala Ala Phe Asp Ile Pro Asp Ile Asp Ala Asn Glu Ala Ile His
          15                  20                  25

 tct ggg cca gaa gaa aat gag ggg cct gga ggc cca ggg aag cca gaa      207
 Ser Gly Pro Glu Glu Asn Glu Gly Pro Gly Gly Pro Gly Lys Pro Glu
      30                  35                  40

 cca ggt gta gga agt gaa tct gaa gac aca gca gca gcc tct gct ggg      255
 Pro Gly Val Gly Ser Glu Ser Glu Asp Thr Ala Ala Ala Ser Ala Gly
  45                  50                  55                  60

 gat ggc cct gga gtt cca gcc cag gcc tct gac cat ggc ctg cca ccg      303
 Asp Gly Pro Gly Val Pro Ala Gln Ala Ser Asp His Gly Leu Pro Pro
                  65                  70                  75

 cca gac att tct gta gtc agt gtc att gtc aag aac act gtg tgt ccc      351
 Pro Asp Ile Ser Val Val Ser Val Ile Val Lys Asn Thr Val Cys Pro
              80                  85                  90

 gag cag tct gag gcc ctg gct gga ggc tca gca gga gac ggg gcc cag      399
 Glu Gln Ser Glu Ala Leu Ala Gly Gly Ser Ala Gly Asp Gly Ala Gln
          95                 100                 105

 gct gct ggg gta act aaa gaa ggg cct gtg ggg cct cat cga atg cag      447
 Ala Ala Gly Val Thr Lys Glu Gly Pro Val Gly Pro His Arg Met Gln
     110                 115                 120

 aat ggt ttt ggg agc cct gaa cct tcc ctc cca gga act ccc cac tct      495
 Asn Gly Phe Gly Ser Pro Glu Pro Ser Leu Pro Gly Thr Pro His Ser
 125                 130                 135                 140

 cct gct cct ccc agt ggg ggc acc tgg aaa gaa aaa ggc atg gaa ggc      543
 Pro Ala Pro Pro Ser Gly Gly Thr Trp Lys Glu Lys Gly Met Glu Gly
                 145                 150                 155

 aaa act ccc ttg gac ctg ttt gct cat ttt ggc cct gag cca ggg gac      591
 Lys Thr Pro Leu Asp Leu Phe Ala His Phe Gly Pro Glu Pro Gly Asp
             160                 165                 170

 cac tca gat ccg ctg cct ccc tct gca ccc tct ccc act cgg gag ggg      639
 His Ser Asp Pro Leu Pro Pro Ser Ala Pro Ser Pro Thr Arg Glu Gly
         175                 180                 185

 gct ctg acc ccg cct cct ttc ccc tct tcc ttt gag ctg gcc cag gag      687
 Ala Leu Thr Pro Pro Pro Phe Pro Ser Ser Phe Glu Leu Ala Gln Glu
     190                 195                 200

 aat ggc cca ggc atg cag cca cct gtt tct tcc cca cca ttg ggg gcc      735
 Asn Gly Pro Gly Met Gln Pro Pro Val Ser Ser Pro Pro Leu Gly Ala
 205                 210                 215                 220

 ttg aag cag gag agc tgc agc ccc cat cat ccc cag gtc cta gcc caa      783
 Leu Lys Gln Glu Ser Cys Ser Pro His His Pro Gln Val Leu Ala Gln
                 225                 230                 235

 caa ggc tca ggc tcc agc cct aag gcc acg gac atc cct gcc agt gcc      831
 Gln Gly Ser Gly Ser Ser Pro Lys Ala Thr Asp Ile Pro Ala Ser Ala
             240                 245                 250

 tcg cct ccc cca gtt gct ggg gtg ccc ttc ttc aag cag tct cca ggg      879
 Ser Pro Pro Pro Val Ala Gly Val Pro Phe Phe Lys Gln Ser Pro Gly
         255                 260                 265

 cac cag agc cct ctt gcc tcc ccc aaa gtg ccc gtc tgt cag ccc ttg      927
 His Gln Ser Pro Leu Ala Ser Pro Lys Val Pro Val Cys Gln Pro Leu
     270                 275                 280

 aag gaa gaa gat gat gat gag ggg cca gtg gac aag tct tcc cca gga      975
 Lys Glu Glu Asp Asp Asp Glu Gly Pro Val Asp Lys Ser Ser Pro Gly
 285                 290                 295                 300

 agt ccc cag agt ccc tct agt ggg gcc gag gct gca gat gag gac agc     1023
 Ser Pro Gln Ser Pro Ser Ser Gly Ala Glu Ala Ala Asp Glu Asp Ser
                 305                 310                 315

 aat gac tcc cct gcc tcc agc tcc tct agg cct ctt aag gtg cgg atc     1071
 Asn Asp Ser Pro Ala Ser Ser Ser Ser Arg Pro Leu Lys Val Arg Ile
             320                 325                 330

 aag acc att aaa aca tcc tgc ggg aat atc aca agg act gta act cag     1119
 Lys Thr Ile Lys Thr Ser Cys Gly Asn Ile Thr Arg Thr Val Thr Gln
         335                 340                 345

 gtc ccc tca gat cct gat cca cct gcc ccc ttg gct gag ggg gcc ttc     1167
 Val Pro Ser Asp Pro Asp Pro Pro Ala Pro Leu Ala Glu Gly Ala Phe
     350                 355                 360

 ttg gct gag gct agc ctc ttg aag ctg tcc cct gca aca cct act tct     1215
 Leu Ala Glu Ala Ser Leu Leu Lys Leu Ser Pro Ala Thr Pro Thr Ser
 365                 370                 375                 380

 gag ggt cca aag gtg gtg agc gta cag ttg ggt gat ggt aca agg ctg     1263
 Glu Gly Pro Lys Val Val Ser Val Gln Leu Gly Asp Gly Thr Arg Leu
                 385                 390                 395

 aaa ggc act gtg ctg cct gtg gcc acc atc cag aac gcc agt act gcc     1311
 Lys Gly Thr Val Leu Pro Val Ala Thr Ile Gln Asn Ala Ser Thr Ala
             400                 405                 410

 atg ctg atg gca gcc agt gtg gct cgc aag gct gtg gtg ctg cct ggg     1359
 Met Leu Met Ala Ala Ser Val Ala Arg Lys Ala Val Val Leu Pro Gly
         415                 420                 425

 ggg act gcc acc agc cct aag atg att gct aag aac gtg cta ggc ctg     1407
 Gly Thr Ala Thr Ser Pro Lys Met Ile Ala Lys Asn Val Leu Gly Leu
     430                 435                 440

 gtg ccc caa gcc ctg cct aag gct gac ggg cgg gca ggg ctg ggg act     1455
 Val Pro Gln Ala Leu Pro Lys Ala Asp Gly Arg Ala Gly Leu Gly Thr
 445                 450                 455                 460

 ggg gga cag aag gtg aat ggt gcc tcg gtg gtg atg gtg caa cct tca     1503
 Gly Gly Gln Lys Val Asn Gly Ala Ser Val Val Met Val Gln Pro Ser
                 465                 470                 475

 aag aca gct act ggg cca agt aca ggg ggc ggc aca gtg ata tca cgg     1551
 Lys Thr Ala Thr Gly Pro Ser Thr Gly Gly Gly Thr Val Ile Ser Arg
             480                 485                 490

 acc cag tcc agc ctg gtg gag gcc ttc aac aag atc ctc aac agc aag     1599
 Thr Gln Ser Ser Leu Val Glu Ala Phe Asn Lys Ile Leu Asn Ser Lys
         495                 500                 505

 aac ctg ctc cct gcc tat agg cca aac ctg agc cca cca gct gag gct     1647
 Asn Leu Leu Pro Ala Tyr Arg Pro Asn Leu Ser Pro Pro Ala Glu Ala
     510                 515                 520

 ggg ctg gcc ctg cct ccc acc ggc tac cgc tgc ctg gag tgt ggg gat     1695
 Gly Leu Ala Leu Pro Pro Thr Gly Tyr Arg Cys Leu Glu Cys Gly Asp
 525                 530                 535                 540

 gcc ttc tca ttg gag aag agc ctg gca cgg cac tat gac cgt cgg agc     1743
 Ala Phe Ser Leu Glu Lys Ser Leu Ala Arg His Tyr Asp Arg Arg Ser
                 545                 550                 555

 atg cgc atc gag gtc acc tgc aac cac tgc gcc cgc cgc ctg gtc ttc     1791
 Met Arg Ile Glu Val Thr Cys Asn His Cys Ala Arg Arg Leu Val Phe
             560                 565                 570

 ttc aac aag tgc agc ctg ctc ctg cat gca cgt gaa cac aag gac aag     1839
 Phe Asn Lys Cys Ser Leu Leu Leu His Ala Arg Glu His Lys Asp Lys
         575                 580                 585

 ggg ctc gtc atg cag tgc tca cat ttg gtc atg agg cct gta gcc ctt     1887
 Gly Leu Val Met Gln Cys Ser His Leu Val Met Arg Pro Val Ala Leu
     590                 595                 600

 gac cag atg gtg ggg cag ccg gac atc aca ccg ctg ctg cct gta gct     1935
 Asp Gln Met Val Gly Gln Pro Asp Ile Thr Pro Leu Leu Pro Val Ala
 605                 610                 615                 620

 gtc cca cct gtc tct gga cct ctg gcc ttg cct gcc ttg ggc aag agt     1983
 Val Pro Pro Val Ser Gly Pro Leu Ala Leu Pro Ala Leu Gly Lys Ser
                 625                 630                 635

 gag ggg gcc atc acc tcc tct gcc att act aca gtt gct gct gag gcc     2031
 Glu Gly Ala Ile Thr Ser Ser Ala Ile Thr Thr Val Ala Ala Glu Ala
             640                 645                 650

 cct gtc ctg ccg ctc tcc aca gag ccg cct gct gcc ccg gcc acc tct     2079
 Pro Val Leu Pro Leu Ser Thr Glu Pro Pro Ala Ala Pro Ala Thr Ser
         655                 660                 665

 gct tac aca tgc ttt cgc tgc ctg gag tgc aag gaa cag tgc cgg gac     2127
 Ala Tyr Thr Cys Phe Arg Cys Leu Glu Cys Lys Glu Gln Cys Arg Asp
     670                 675                 680

 aag gct ggc atg gca gct cac ttc cag cag ctc ggc ccc cct gcc cct     2175
 Lys Ala Gly Met Ala Ala His Phe Gln Gln Leu Gly Pro Pro Ala Pro
 685                 690                 695                 700

 ggg gcc acc agc aat gtg tgc cca acc tgc ccc atg atg ctc ccc aat     2223
 Gly Ala Thr Ser Asn Val Cys Pro Thr Cys Pro Met Met Leu Pro Asn
                 705                 710                 715

 cgc tgc agc ttc agc gcc cac cag cgc atg cat aag aat cga ccc ccc     2271
 Arg Cys Ser Phe Ser Ala His Gln Arg Met His Lys Asn Arg Pro Pro
             720                 725                 730

 cat gtc tgt cct gag tgt ggg ggc aac ttc ctg caa gcc aat ttt cag     2319
 His Val Cys Pro Glu Cys Gly Gly Asn Phe Leu Gln Ala Asn Phe Gln
         735                 740                 745

 acc cat ctc cgg gag gcc tgt ctg cac gtc tct cgc cgt gta gga tac     2367
 Thr His Leu Arg Glu Ala Cys Leu His Val Ser Arg Arg Val Gly Tyr
     750                 755                 760

 agg tgc ccc agc tgt tca gtg gtg ttt ggg ggt gtg aac tcc atc aag     2415
 Arg Cys Pro Ser Cys Ser Val Val Phe Gly Gly Val Asn Ser Ile Lys
 765                 770                 775                 780

 tcc cac atc cag acg tcg cac tgc gag gtt ttc cag tcg acg cgg ccg     2463
 Ser His Ile Gln Thr Ser His Cys Glu Val Phe Gln Ser Thr Arg Pro
                 785                 790                 795

 cga att tag tag                                                     2475
 Arg Ile 






      <210> 454
      <211> 729
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(669)

      <400> 454
  atg gcg gcg ccc gtt gtc acg gcc ccg ggc aga gct ctg ctg cgg gcg      48
  Met Ala Ala Pro Val Val Thr Ala Pro Gly Arg Ala Leu Leu Arg Ala
    1               5                  10                  15

 ggc gct gga cgg ctg ctt cgg gga ggc gtc cag gag cta ctg cgg ccg       96
 Gly Ala Gly Arg Leu Leu Arg Gly Gly Val Gln Glu Leu Leu Arg Pro
              20                  25                  30

 cga cat gaa ggg aac gcc cct gac ctg gcc tgc aac ttc agc ctt tct      144
 Arg His Glu Gly Asn Ala Pro Asp Leu Ala Cys Asn Phe Ser Leu Ser
          35                  40                  45

 caa aat cgg ggc acg gtc atc gtg gag cgc tgg tgg aag gta ccg ctg      192
 Gln Asn Arg Gly Thr Val Ile Val Glu Arg Trp Trp Lys Val Pro Leu
      50                  55                  60

 gcc ggg gag ggc cgg aag ccg cgc ctg cac cgg cga cat cgc gtc tat      240
 Ala Gly Glu Gly Arg Lys Pro Arg Leu His Arg Arg His Arg Val Tyr
  65                  70                  75                  80

 aag ctg gtg gag gac acg aag cat cgg ccc aaa gaa aac ctg gag ctc      288
 Lys Leu Val Glu Asp Thr Lys His Arg Pro Lys Glu Asn Leu Glu Leu
                  85                  90                  95

 atc ctg acg cag tcg gtg gag aat gtt gga gtc cgg ggt gac ctg gtc      336
 Ile Leu Thr Gln Ser Val Glu Asn Val Gly Val Arg Gly Asp Leu Val
             100                 105                 110

 tca gtg aag aaa tct tta ggc cgg aat cga ctc ctt cct cag gga ctg      384
 Ser Val Lys Lys Ser Leu Gly Arg Asn Arg Leu Leu Pro Gln Gly Leu
         115                 120                 125

 gct gta tat gca tcc cct gaa aac aag aag ctg ttt gaa gag gag aaa      432
 Ala Val Tyr Ala Ser Pro Glu Asn Lys Lys Leu Phe Glu Glu Glu Lys
     130                 135                 140

 ttg ctg aga caa gaa gga aaa tta gag aag atc cag acc aag gca ggt      480
 Leu Leu Arg Gln Glu Gly Lys Leu Glu Lys Ile Gln Thr Lys Ala Gly
 145                 150                 155                 160

 gag gcg aca gtg aaa ttt cta aaa agc tgt cgc ctg gag gta ggg atg      528
 Glu Ala Thr Val Lys Phe Leu Lys Ser Cys Arg Leu Glu Val Gly Met
                 165                 170                 175

 aag aac aat gtc aaa tgg gag ctg aac cct gaa ata gtt gcc cgc cac      576
 Lys Asn Asn Val Lys Trp Glu Leu Asn Pro Glu Ile Val Ala Arg His
             180                 185                 190

 ttc ttt aag aat gta aat ggg ctt gat act gtg aga gtg cct atg tct      624
 Phe Phe Lys Asn Val Asn Gly Leu Asp Thr Val Arg Val Pro Met Ser
         195                 200                 205

 gtc gtg aac ttt gag aag ccc aag acc aaa aga tat aag tac tga tac      672
 Val Val Asn Phe Glu Lys Pro Lys Thr Lys Arg Tyr Lys Tyr 
     210                 215                 220

 attgatgtag tcatcaatgt gaataagcac aatggattct gcttctctaa gacctga       729




      <210> 455
      <211> 840
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (25)..(840)

      <400> 455
 cgtcccgccg cccgcccgcc agcc   atg agc tcc acg cag ttc aac aag ggc      51
                              Met Ser Ser Thr Gln Phe Asn Lys Gly
                                1               5

 ccc tcg tac ggg ctg tcg gcc gag gtc aag aac cgg ctc ctg tcc aaa       99
 Pro Ser Tyr Gly Leu Ser Ala Glu Val Lys Asn Arg Leu Leu Ser Lys
  10                  15                  20                  25

 tat gac ccc cag aag gag gca gag ctc cgc acc tgg atc gag gga ctc      147
 Tyr Asp Pro Gln Lys Glu Ala Glu Leu Arg Thr Trp Ile Glu Gly Leu
                  30                  35                  40

 acc ggc ctc tcc atc ggc ccc gac ttc cag aag ggc ctg aag gat gga      195
 Thr Gly Leu Ser Ile Gly Pro Asp Phe Gln Lys Gly Leu Lys Asp Gly
              45                  50                  55

 act atc tta tgc aca ctc atg aac aag cta cag ccg ggc tcc gtc ccc      243
 Thr Ile Leu Cys Thr Leu Met Asn Lys Leu Gln Pro Gly Ser Val Pro
          60                  65                  70

 aag atc aac cgc tcc atg cag aac tgg cac cag cta gaa aac ctg tcc      291
 Lys Ile Asn Arg Ser Met Gln Asn Trp His Gln Leu Glu Asn Leu Ser
      75                  80                  85

 aac ttc atc aag gcc atg gtc agc tac ggc atg aac cct gtg gac ctg      339
 Asn Phe Ile Lys Ala Met Val Ser Tyr Gly Met Asn Pro Val Asp Leu
  90                  95                 100                 105

 ttc gag gcc aac gac ctg ttt gag agt ggg aac aat atg cag gtg cgg      387
 Phe Glu Ala Asn Asp Leu Phe Glu Ser Gly Asn Asn Met Gln Val Arg
                 110                 115                 120

 gtg tct ctt ctt gcc ctg gca ggg aag gcc aag act aag ggg ctg cgg      435
 Val Ser Leu Leu Ala Leu Ala Gly Lys Ala Lys Thr Lys Gly Leu Arg
             125                 130                 135

 agc ggg gtg gac atc cgt gac aag tac tca aag aag cag aac ttc gac      483
 Ser Gly Val Asp Ile Arg Asp Lys Tyr Ser Lys Lys Gln Asn Phe Asp
         140                 145                 150

 gac acc acc atg aag gcc agc cag tgc gtc atc cgg ctg cag atg ggc      531
 Asp Thr Thr Met Lys Ala Ser Gln Cys Val Ile Arg Leu Gln Met Gly
     155                 160                 165

 acc aac aaa tgt gcc agc cag tca ggc atg acc gca tat ggc acg agg      579
 Thr Asn Lys Cys Ala Ser Gln Ser Gly Met Thr Ala Tyr Gly Thr Arg
 170                 175                 180                 185

 agg cat ctc tac gac ccc aag aac cgc atc ctg ccc ccc atg gac aat      627
 Arg His Leu Tyr Asp Pro Lys Asn Arg Ile Leu Pro Pro Met Asp Asn
                 190                 195                 200

 tcg acc atc agc ctc cag atg ggt aca aac aag tac gcc agc cag gtg      675
 Ser Thr Ile Ser Leu Gln Met Gly Thr Asn Lys Tyr Ala Ser Gln Val
             205                 210                 215

 ggc atg acg gct ccc ggg acc cag cgg cac atc tat gac acc aat ttg      723
 Gly Met Thr Ala Pro Gly Thr Gln Arg His Ile Tyr Asp Thr Asn Leu
         220                 225                 230

 gga atc gac aag tgt gag aac tcc tcc atg tcc ctg aag atg ggc tac      771
 Gly Ile Asp Lys Cys Glu Asn Ser Ser Met Ser Leu Lys Met Gly Tyr
     235                 240                 245

 acg cag gtt gcc aat cac agc ggc cag gtc ttt ggc cta ggc cgg caa      819
 Thr Gln Val Ala Asn His Ser Gly Gln Val Phe Gly Leu Gly Arg Gln
 250                 255                 260                 265

 ata tac gaa ccc aag tac tag                                          840
 Ile Tyr Glu Pro Lys Tyr 
                 270





      <210> 456
      <211> 1923
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (40)..(1923)

      <400> 456
 gggttgcaga cgctcctgtc cgggtcgcag tgggacgcc   atg gag cgc tcc ctg      54
                                              Met Glu Arg Ser Leu
                                                1               5

 cac cgc gtc tcc ctc ggg agc cgg cgt gcc cac ccg gac ttg tcc ttc      102
 His Arg Val Ser Leu Gly Ser Arg Arg Ala His Pro Asp Leu Ser Phe
                  10                  15                  20

 tac ctc acc acc ttt ggt cag ctg agg ctg tcc att gat gcc cag gac      150
 Tyr Leu Thr Thr Phe Gly Gln Leu Arg Leu Ser Ile Asp Ala Gln Asp
              25                  30                  35

 cgg gtt ctg ctg ctt cac att ata gaa ggt aaa ggc ctg atc agc aaa      198
 Arg Val Leu Leu Leu His Ile Ile Glu Gly Lys Gly Leu Ile Ser Lys
          40                  45                  50

 cag cct ggc acc tgt gat ccg tat gtg aag tgc ctg cca acc gtg gac      246
 Gln Pro Gly Thr Cys Asp Pro Tyr Val Lys Cys Leu Pro Thr Val Asp
      55                  60                  65

 gtg atg gat tca tcc att tgt caa gcc ttc act aag tgc acc aag cct      294
 Val Met Asp Ser Ser Ile Cys Gln Ala Phe Thr Lys Cys Thr Lys Pro
  70                  75                  80                  85

 gga gct cag gga ctg gta gtc aga att aac caa ggc ttg gtt ccg gag      342
 Gly Ala Gln Gly Leu Val Val Arg Ile Asn Gln Gly Leu Val Pro Glu
                  90                  95                 100

 act ttg cat cta gtg aga gtt cag gca ctc ccg agg gag atc agt ggt      390
 Thr Leu His Leu Val Arg Val Gln Ala Leu Pro Arg Glu Ile Ser Gly
             105                 110                 115

 tgg tac tac ctc cta ggg gag cac ctg ggc cgg acc aag cac ttg aag      438
 Trp Tyr Tyr Leu Leu Gly Glu His Leu Gly Arg Thr Lys His Leu Lys
         120                 125                 130

 gtg gcc agg cgg cga ctg cgg ccg ctg aga gac ccg ctg ctg aga atg      486
 Val Ala Arg Arg Arg Leu Arg Pro Leu Arg Asp Pro Leu Leu Arg Met
     135                 140                 145

 cca gga ggt ggg gac act gag aat ggg aag aaa cta aag ggt gct cat      534
 Pro Gly Gly Gly Asp Thr Glu Asn Gly Lys Lys Leu Lys Gly Ala His
 150                 155                 160                 165

 gcc agg ctg acg ggt cca gtg cgg gct ccc gct gct ggg gga gag ctg      582
 Ala Arg Leu Thr Gly Pro Val Arg Ala Pro Ala Ala Gly Gly Glu Leu
                 170                 175                 180

 ggt ttt cat ggg gcg gca gcc gag gca gga ccc gca gcc atg aac cgc      630
 Gly Phe His Gly Ala Ala Ala Glu Ala Gly Pro Ala Ala Met Asn Arg
             185                 190                 195

 ttc aat ggg ctc tgc aag gtg tgc tcg gag cgc cgc tac cgc cag atc      678
 Phe Asn Gly Leu Cys Lys Val Cys Ser Glu Arg Arg Tyr Arg Gln Ile
         200                 205                 210

 acc atc ccg agg gga aag gac ggc ttt ggc ttc acc atc tgc tgc gac      726
 Thr Ile Pro Arg Gly Lys Asp Gly Phe Gly Phe Thr Ile Cys Cys Asp
     215                 220                 225

 tct cca gtt cga gtc cag gcc gtg gat tcc ggg ggt ccg gcg gaa cgg      774
 Ser Pro Val Arg Val Gln Ala Val Asp Ser Gly Gly Pro Ala Glu Arg
 230                 235                 240                 245

 gca ggg ctg cag cag ctg gac acg gtg ctg cag ctg aat gag agg cct      822
 Ala Gly Leu Gln Gln Leu Asp Thr Val Leu Gln Leu Asn Glu Arg Pro
                 250                 255                 260

 gtg gag cac tgg aaa tgt gtg gag ctg gcc cac gag atc cgg agc tgc      870
 Val Glu His Trp Lys Cys Val Glu Leu Ala His Glu Ile Arg Ser Cys
             265                 270                 275

 ccc agt gag atc atc cta ctc gtg tgg cgc atg gtc ccc cag gtc aag      918
 Pro Ser Glu Ile Ile Leu Leu Val Trp Arg Met Val Pro Gln Val Lys
         280                 285                 290

 cca gga cca gat ggc ggg gtc ctg cgg cgg gcc tcc tgc aag tcg aca      966
 Pro Gly Pro Asp Gly Gly Val Leu Arg Arg Ala Ser Cys Lys Ser Thr
     295                 300                 305

 cat gac ctc cag tca ccc ccc aac aaa cgg gag aag aac tgc acc cat     1014
 His Asp Leu Gln Ser Pro Pro Asn Lys Arg Glu Lys Asn Cys Thr His
 310                 315                 320                 325

 ggg gtc cag gca cgg cct gag cag cgc cac agc tgc cac ctg gta tgt     1062
 Gly Val Gln Ala Arg Pro Glu Gln Arg His Ser Cys His Leu Val Cys
                 330                 335                 340

 gac agc tct gat ggg ctg ctg ctc ggc ggc tgg gag cgc tac acc gag     1110
 Asp Ser Ser Asp Gly Leu Leu Leu Gly Gly Trp Glu Arg Tyr Thr Glu
             345                 350                 355

 gtg gcc aag cgc ggg ggc cag cac acc ctg cct gca ctg tcc cgt gcc     1158
 Val Ala Lys Arg Gly Gly Gln His Thr Leu Pro Ala Leu Ser Arg Ala
         360                 365                 370

 act gcc ccc acc gac ccc aac tac atc atc ctg gcc ccg ctg aat cct     1206
 Thr Ala Pro Thr Asp Pro Asn Tyr Ile Ile Leu Ala Pro Leu Asn Pro
     375                 380                 385

 ggg agc cag ctg ctc cgg cct gtg tac cag gag gat acc atc ccc gaa     1254
 Gly Ser Gln Leu Leu Arg Pro Val Tyr Gln Glu Asp Thr Ile Pro Glu
 390                 395                 400                 405

 gaa tca ggg agt ccc agt aaa ggg aag tcc tac aca ggc ctg ggg aag     1302
 Glu Ser Gly Ser Pro Ser Lys Gly Lys Ser Tyr Thr Gly Leu Gly Lys
                 410                 415                 420

 aag tcc cgg ctg atg aag aca gtg cag acc atg aag ggc cac ggg aac     1350
 Lys Ser Arg Leu Met Lys Thr Val Gln Thr Met Lys Gly His Gly Asn
             425                 430                 435

 tac caa aac tgc ccg gtt gtg agg ccg cat gcc acg cac tca agc tat     1398
 Tyr Gln Asn Cys Pro Val Val Arg Pro His Ala Thr His Ser Ser Tyr
         440                 445                 450

 ggc acc tac gtc acc ctg gcc ccc aaa gtc ctg gtg ttc cct gtc ttt     1446
 Gly Thr Tyr Val Thr Leu Ala Pro Lys Val Leu Val Phe Pro Val Phe
     455                 460                 465

 gtt cag cct cta gat ctc tgt aat cct gcc cgg acc ctc ctg ctg tca     1494
 Val Gln Pro Leu Asp Leu Cys Asn Pro Ala Arg Thr Leu Leu Leu Ser
 470                 475                 480                 485

 gag gag ctg ctg ctg tat gaa ggg agg aac aag gct gcc gag gtg aca     1542
 Glu Glu Leu Leu Leu Tyr Glu Gly Arg Asn Lys Ala Ala Glu Val Thr
                 490                 495                 500

 ctg ttt gcc tat tcg gac ctg ctg ctc ttc acc aag gag gac gag cct     1590
 Leu Phe Ala Tyr Ser Asp Leu Leu Leu Phe Thr Lys Glu Asp Glu Pro
             505                 510                 515

 ggc cgc tgc gac gtc ctg agg aac ccc ctc tac ctc cag agt gtg aag     1638
 Gly Arg Cys Asp Val Leu Arg Asn Pro Leu Tyr Leu Gln Ser Val Lys
         520                 525                 530

 ctg cag gaa ggt tct tca gaa gac ctg aaa ttc tgc gtg ctc tat cta     1686
 Leu Gln Glu Gly Ser Ser Glu Asp Leu Lys Phe Cys Val Leu Tyr Leu
     535                 540                 545

 gca gag aag gca gag tgc tta ttc act ttg gaa gcg cac tcg cag gag     1734
 Ala Glu Lys Ala Glu Cys Leu Phe Thr Leu Glu Ala His Ser Gln Glu
 550                 555                 560                 565

 cag aag aag aga gtg tgc tgg tgc ctg tcg gag aac atc gcc aag cag     1782
 Gln Lys Lys Arg Val Cys Trp Cys Leu Ser Glu Asn Ile Ala Lys Gln
                 570                 575                 580

 caa cag ctg gca gca tca ccc ccg gac agc aag aaa ctc cac cct ttc     1830
 Gln Gln Leu Ala Ala Ser Pro Pro Asp Ser Lys Lys Leu His Pro Phe
             585                 590                 595

 ggc tct ctc cag cag gag atg ggg ccg gtc aac tca acc aat gcc acc     1878
 Gly Ser Leu Gln Gln Glu Met Gly Pro Val Asn Ser Thr Asn Ala Thr
         600                 605                 610

 cag gat aga agc ttt acc tca cca gga cag act ctg att ggc tga         1923
 Gln Asp Arg Ser Phe Thr Ser Pro Gly Gln Thr Leu Ile Gly 
     615                 620                 625





      <210> 457
      <211> 1251
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (715)..(1251)

      <400> 457
 ccgggaacgg gcggtgggga gcgggcggag ctggccctgc ctctgcctgg ccggcgccgc     60

 agtcggcgcg ggccgcgccc gccgccgcca actgccctga gcgcttgctg aggccgaggg    120

 agacgtcggg gcctgcacct ggagggagcc tgccgcgctg gccccgagga gggggcgttg    180

 ccatggcgac agcctctccc gctgctgacg gggggcgggg gcggccctgg gaaggagggc    240

 tggtctcctg gccccccgcc cctcccctta ctctcccctg gacttggatg ggcccgagtt    300

 gggggcaaca ccccgggcat tggggctttc cagctctcac agaaccttca gcatccccag    360

 ctgccggtct tggcatcttc gaagtaagga gagttttaga tgcttctgga tgttcaatgc    420

 tagcaccttt acagactgga gcagctcgat tttcttcgta tttactttca agagcaagaa    480

 aagtgctggg ctcccactta ttttctccct gtggtgttcc ggagttctgc tccatatcca    540

 ccagaaagct ggcggcccac ggctttggcg catccatggc ggcaatggtg tccttccctc    600

 cccagaggta tcactacttt ttagtgctgg actttgaggc cacgtgcgca caagccacag    660

 attcatcctc aggaaatcat cgagttcccc atcctaaagc taaatggccg gacc  atg     717
                                                              Met
                                                                1

 gag att gag tct acc ttt cac atg tat gtc cag cct gta gtc cat cca      765
 Glu Ile Glu Ser Thr Phe His Met Tyr Val Gln Pro Val Val His Pro
               5                  10                  15

 cag ctt acc cca ttc tgt aca gag ctc acc ggg att att caa gcc atg      813
 Gln Leu Thr Pro Phe Cys Thr Glu Leu Thr Gly Ile Ile Gln Ala Met
          20                  25                  30

 gtg gat ggt cag cca agc ctg cag caa gtg ctg gag agg gtc gat gaa      861
 Val Asp Gly Gln Pro Ser Leu Gln Gln Val Leu Glu Arg Val Asp Glu
      35                  40                  45

 tgg atg gcg aag gaa ggc ctc tta gat cca aac gtc aag tca att ttt      909
 Trp Met Ala Lys Glu Gly Leu Leu Asp Pro Asn Val Lys Ser Ile Phe
  50                  55                  60                  65

 gtc acc tgt gga gac tgg gac tta aaa gtc atg ctc cca ggc cag tgc      957
 Val Thr Cys Gly Asp Trp Asp Leu Lys Val Met Leu Pro Gly Gln Cys
                  70                  75                  80

 cag tac ttg ggc ttg cca gtg gcg gat tac ttc aag cag tgg att aat     1005
 Gln Tyr Leu Gly Leu Pro Val Ala Asp Tyr Phe Lys Gln Trp Ile Asn
              85                  90                  95

 ctg aaa aag gct tac agc ttc gcc atg ggc tgc tgg ccc aag aat gga     1053
 Leu Lys Lys Ala Tyr Ser Phe Ala Met Gly Cys Trp Pro Lys Asn Gly
         100                 105                 110

 ctt cta gac atg aac aag ggc ctc agc ctg caa cac ata ggc cgg ccc     1101
 Leu Leu Asp Met Asn Lys Gly Leu Ser Leu Gln His Ile Gly Arg Pro
     115                 120                 125

 cac agc ggc att gtg tcc tca ttt tgc aaa gaa tct gtc ctg gta gtt     1149
 His Ser Gly Ile Val Ser Ser Phe Cys Lys Glu Ser Val Leu Val Val
 130                 135                 140                 145

 cag gcc att ctg gaa gag gac gac tgc aag aac att gcc aac atc atg     1197
 Gln Ala Ile Leu Glu Glu Asp Asp Cys Lys Asn Ile Ala Asn Ile Met
                 150                 155                 160

 aag aca ctc gcc tat cga ggc ttc atc ttc aag cag aca tcg aag ccg     1245
 Lys Thr Leu Ala Tyr Arg Gly Phe Ile Phe Lys Gln Thr Ser Lys Pro
             165                 170                 175

 ttc tga                                                             1251
 Phe 






      <210> 458
      <211> 1004
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (243)..(1004)

      <400> 458
 agcggggtcg cagcctccga cgcttccggg cagataggtg ccttttcttg ctccttgctc     60

 ttggagttct tctcttagtc cctgttccct ggatgaaagc atcgctccga gcctcatggg    120

 aggaatgaag gaaggatcga gactagatat ccaactaagg cttcgggaca tgttttgagc    180

 gaagatgggt gtttctgccc ggatagtata aatcgaggat ccaggtctgg gcagattcaa    240

 cc   atg gga gcc aac act tca aga aaa cca cca gtg ttt gat gaa aat     287
      Met Gly Ala Asn Thr Ser Arg Lys Pro Pro Val Phe Asp Glu Asn
        1               5                  10                  15

 gaa gat gtc aac ttt gac cac ttt gaa att ttg cga gcc att ggg aaa      335
 Glu Asp Val Asn Phe Asp His Phe Glu Ile Leu Arg Ala Ile Gly Lys
                  20                  25                  30

 ggc agt ttt ggg aag gtc tgc att gta cag aag aat gat acc aag aag      383
 Gly Ser Phe Gly Lys Val Cys Ile Val Gln Lys Asn Asp Thr Lys Lys
              35                  40                  45

 atg tac gca atg aag tac atg aat aaa caa aag tgc gtg gag cgc aat      431
 Met Tyr Ala Met Lys Tyr Met Asn Lys Gln Lys Cys Val Glu Arg Asn
          50                  55                  60

 gaa gtg aga aat gtc ttc aag gaa ctc cag atc atg cag ggt ctg gag      479
 Glu Val Arg Asn Val Phe Lys Glu Leu Gln Ile Met Gln Gly Leu Glu
      65                  70                  75

 cac cct ttc ctg gtt aat ttg tgg tat tcc ttc caa gat gag gaa gac      527
 His Pro Phe Leu Val Asn Leu Trp Tyr Ser Phe Gln Asp Glu Glu Asp
  80                  85                  90                  95

 atg ttc atg gtg gtg gac ctc ctg ctg ggt gga gac ctg cgt tat cac      575
 Met Phe Met Val Val Asp Leu Leu Leu Gly Gly Asp Leu Arg Tyr His
                 100                 105                 110

 ctg caa cag aac gtc cac ttc aag gaa gaa aca gtg aag ctc ttc atc      623
 Leu Gln Gln Asn Val His Phe Lys Glu Glu Thr Val Lys Leu Phe Ile
             115                 120                 125

 tgt gag ctg gtc atg gcc ctg gac tac ctg cag aac cag cgc atc att      671
 Cys Glu Leu Val Met Ala Leu Asp Tyr Leu Gln Asn Gln Arg Ile Ile
         130                 135                 140

 cac agg tca gtc aag tcc aag gag atg gcc atg aac tta tta ctt agt      719
 His Arg Ser Val Lys Ser Lys Glu Met Ala Met Asn Leu Leu Leu Ser
     145                 150                 155

 gcc cgt tct cag aag ggc ctt ttt gta ctg aaa tgt ctc ctc acc atg      767
 Ala Arg Ser Gln Lys Gly Leu Phe Val Leu Lys Cys Leu Leu Thr Met
 160                 165                 170                 175

 gta aag atg ctc agc atg gct gca gct ctg agg gga gca cgg gac acc      815
 Val Lys Met Leu Ser Met Ala Ala Ala Leu Arg Gly Ala Arg Asp Thr
                 180                 185                 190

 tat gca tgg cca cct gcc tca ggc acc cac aga cga aag tgg tac atg      863
 Tyr Ala Trp Pro Pro Ala Ser Gly Thr His Arg Arg Lys Trp Tyr Met
             195                 200                 205

 tgg aac gga cag aca gag aac agc cta aaa ttg gaa gct aaa ttg tgt      911
 Trp Asn Gly Gln Thr Glu Asn Ser Leu Lys Leu Glu Ala Lys Leu Cys
         210                 215                 220

 gag aaa gac aag tac ttc aga gaa gat agt gtg gag tcg caa aat aag      959
 Glu Lys Asp Lys Tyr Phe Arg Glu Asp Ser Val Glu Ser Gln Asn Lys
     225                 230                 235

 ttt cat gag agc tca tac aga aaa cag cct aaa act aga agc taa         1004
 Phe His Glu Ser Ser Tyr Arg Lys Gln Pro Lys Thr Arg Ser 
 240                 245                 250





      <210> 459
      <211> 1607
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (717)..(1508)

      <400> 459
 ggtggacttt aaaaaataaa aataaagtag gtgatcaata agatggcaga tgagaaaact     60

 gggccagatg acacaaagag agggcaggtt aaggtgggtg ggcccagctc tgggtgacaa    120

 ggcgggcgtc cctgtttcta gacaaaaccc actggccagt ggatgagcag aatctgggct    180

 ccctgtacac cattgaggcc acagcctatg ggctcatgca gaagctggag ctgggccggt    240

 acaatgagac acacgccata gccaagtggc tactagagaa gcaggagctg ggaggaggct    300

 tcaggtccac ccaggtgatg gggacccccc gggagaccac ggtggtggcc cttgaagctc    360

 tgacccgctt ccgcgaagct gtccccttca agggcatcca ggatctccac gtccagatca    420

 gagcccccaa gacagccctg aatgtgaatt ggtacattga tcacagcaat gcctaccaac    480

 agcggtcagc aaagttcctt gcccaggacg acctagagat caaagccagt ggcaacggga    540

 gaggcaccat ctcgatcctg acaatgtatc acaagtcccc agagtcccgg gaggacaact    600

 gcaacctgta ccacctgaat gcgactctcc acagtgccct agaagaaaat aaaaagggag    660

 gtgagacttt tcggctccgg atggaaacaa ggttccagaa caattgagag gccaca        716                                                                 
 atg act atc atg gag gtc tcc ctg ctc acg ggc ttc tac ccc aac cag      764
 Met Thr Ile Met Glu Val Ser Leu Leu Thr Gly Phe Tyr Pro Asn Gln
   1               5                  10                  15

 gat gac ctc aaa cag ctc acg agt gat gtg gag agg tac gcc ttt cag      812
 Asp Asp Leu Lys Gln Leu Thr Ser Asp Val Glu Arg Tyr Ala Phe Gln
              20                  25                  30

 tac aaa acc aag aca agt acc agc gac agc act gtt gtc ctc tac ctg      860
 Tyr Lys Thr Lys Thr Ser Thr Ser Asp Ser Thr Val Val Leu Tyr Leu
          35                  40                  45

 gaa aag ctc tcc cat gag aag aac acg gtg ctg ggc ttt cgg gtt cac      908
 Glu Lys Leu Ser His Glu Lys Asn Thr Val Leu Gly Phe Arg Val His
      50                  55                  60

 agg atg ctg cag gcg gag ttc ctg cag gcc gcc ctg gtc acc atc tac      956
 Arg Met Leu Gln Ala Glu Phe Leu Gln Ala Ala Leu Val Thr Ile Tyr
  65                  70                  75                  80

 gac tac tac gag cct tcc cgg agg tgc agc act ttc tac aac ctg ccc     1004
 Asp Tyr Tyr Glu Pro Ser Arg Arg Cys Ser Thr Phe Tyr Asn Leu Pro
                  85                  90                  95

 aca gag caa tct tcc ctg aga aag atc tgc cac aaa gac atc tgc aga     1052
 Thr Glu Gln Ser Ser Leu Arg Lys Ile Cys His Lys Asp Ile Cys Arg
             100                 105                 110

 tgt gca gag gga cag tgc cca tcc ctg cag aag ccc agt ggc caa ttg     1100
 Cys Ala Glu Gly Gln Cys Pro Ser Leu Gln Lys Pro Ser Gly Gln Leu
         115                 120                 125

 agg cag gag gag ctc cag aca aca gca tgt gag gca ggc gtg gat ttt     1148
 Arg Gln Glu Glu Leu Gln Thr Thr Ala Cys Glu Ala Gly Val Asp Phe
     130                 135                 140

 gtg tac aag aca aag ctg gaa tct gtg gag gtc tct gcc tcc aac cct     1196
 Val Tyr Lys Thr Lys Leu Glu Ser Val Glu Val Ser Ala Ser Asn Pro
 145                 150                 155                 160

 tac gtc tat tac aac acg cag ctc gaa gac atc att aag agt ggt acg     1244
 Tyr Val Tyr Tyr Asn Thr Gln Leu Glu Asp Ile Ile Lys Ser Gly Thr
                 165                 170                 175

 gac cct gcc aca ccc ctg gcc atg aag aaa ttc gtc tcc cat gcc act     1292
 Asp Pro Ala Thr Pro Leu Ala Met Lys Lys Phe Val Ser His Ala Thr
             180                 185                 190

 tgc cat gac tcc ctg ggg ttg caa gaa cag gaa tcg tac ctc atc atg     1340
 Cys His Asp Ser Leu Gly Leu Gln Glu Gln Glu Ser Tyr Leu Ile Met
         195                 200                 205

 ggc cag acg tca gac ctg tgg aga atc aaa tct gat tac agc tat gtt     1388
 Gly Gln Thr Ser Asp Leu Trp Arg Ile Lys Ser Asp Tyr Ser Tyr Val
     210                 215                 220

 ctg ggc aag gag acg ttc ctc atc ctt tgg cca gca gat gga gat gcc     1436
 Leu Gly Lys Glu Thr Phe Leu Ile Leu Trp Pro Ala Asp Gly Asp Ala
 225                 230                 235                 240

 agc aag aaa gaa ttg cgg gac caa ctg gag gaa ttt ttg gaa tat atg     1484
 Ser Lys Lys Glu Leu Arg Asp Gln Leu Glu Glu Phe Leu Glu Tyr Met
                 245                 250                 255

 cgc acc cac ggc tgc cag tcc tga gcctcttctg ctttcaggga ggtgtcatca    1538
 Arg Thr His Gly Cys Gln Ser 
             260

 ggcagctctg ggccactggg tttaacccca aataaagagc acaggatatg acacccaaaa   1598

 aaaaaaaaa                                                           1607




      <210> 460
      <211> 2501
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (232)..(2451)

      <400> 460
 atgactttgg gaaattgctg ctggctgagg ccctcctgga gcagtgtttg aaggagaacc     60

 atgccaaaat aaaagactcc atgcctttgc tggagaagaa tgagccgaag atgagcgaag    120

 ccaaaaatta tctaagcagt atccttaacc atgggaggct ctcgccacag tacatgtgtg    180

 aggccatgct gatcctgggc aaactgcatt acgtggaggg ctcataccga g atg cca     237
                                                          Met Pro
                                                            1

 tca gca tgt acg cac ggg ccg gga ttg atg aca tgt cca tgg aga aca      285
 Ser Ala Cys Thr His Gly Pro Gly Leu Met Thr Cys Pro Trp Arg Thr
           5                  10                  15

 agc ccc tgt atc aga tgc ggc tgc tgt cgg agg ctt ttg tca tca aag      333
 Ser Pro Cys Ile Arg Cys Gly Cys Cys Arg Arg Leu Leu Ser Ser Lys
      20                  25                  30

 cat gcc tcc ggc ttc ttg ggg gaa cac agt ccc ggt ggt cag agg tcc      381
 His Ala Ser Gly Phe Leu Gly Glu His Ser Pro Gly Gly Gln Arg Ser
  35                  40                  45                  50

 tgc agg gga ggc ctc tct ctg gaa cgc cta ccc aac tcc atc gcc tcc      429
 Cys Arg Gly Gly Leu Ser Leu Glu Arg Leu Pro Asn Ser Ile Ala Ser
                  55                  60                  65

 cgc ttc cgc ctg aca gag agg gag gag gaa gtg atc acc tgt ttt gag      477
 Arg Phe Arg Leu Thr Glu Arg Glu Glu Glu Val Ile Thr Cys Phe Glu
              70                  75                  80

 agg gcc tcc tgg atc gct cag gtg ttc ctg cag gaa ttg gag aag acc      525
 Arg Ala Ser Trp Ile Ala Gln Val Phe Leu Gln Glu Leu Glu Lys Thr
          85                  90                  95

 aca aat aac agc acg tcg agg cat ctg aaa ggc tgt cac ccg ctt gac      573
 Thr Asn Asn Ser Thr Ser Arg His Leu Lys Gly Cys His Pro Leu Asp
     100                 105                 110

 tat gag ctc acc tac ttc ctg gaa gct gcc ctc cag agc gcc tat gtg      621
 Tyr Glu Leu Thr Tyr Phe Leu Glu Ala Ala Leu Gln Ser Ala Tyr Val
 115                 120                 125                 130

 aaa aac ctg aag aag ggg aac atc gtg aag ggc atg aga gag ctc cgg      669
 Lys Asn Leu Lys Lys Gly Asn Ile Val Lys Gly Met Arg Glu Leu Arg
                 135                 140                 145

 gaa gtg ctg cgg act gtg gag acc aaa gca act cag aac ttc aaa gtg      717
 Glu Val Leu Arg Thr Val Glu Thr Lys Ala Thr Gln Asn Phe Lys Val
             150                 155                 160

 atg gcg gcc aag cac ctg gcg ggg gtc ctg ctg cac tcc ctg agt gag      765
 Met Ala Ala Lys His Leu Ala Gly Val Leu Leu His Ser Leu Ser Glu
         165                 170                 175

 gag tgc tac tgg agc ccc ctg tcc cac cct ctg cct gag ttc atg ggc      813
 Glu Cys Tyr Trp Ser Pro Leu Ser His Pro Leu Pro Glu Phe Met Gly
     180                 185                 190

 aag gag gag agt tct ttc gcc act cag gcc ctg cgg aaa cct cac ctc      861
 Lys Glu Glu Ser Ser Phe Ala Thr Gln Ala Leu Arg Lys Pro His Leu
 195                 200                 205                 210

 tat gaa gga gac aac ctc tac tgc ccc aag gac aac atc gag gaa gcc      909
 Tyr Glu Gly Asp Asn Leu Tyr Cys Pro Lys Asp Asn Ile Glu Glu Ala
                 215                 220                 225

 ctc ctg ctc ctc ctc atc agc gaa tcc atg gca act cga gat gtg gtg      957
 Leu Leu Leu Leu Leu Ile Ser Glu Ser Met Ala Thr Arg Asp Val Val
             230                 235                 240

 ctg agc cgg gtg ccg gag cag gag gag gac cgg aca gtg agc ttg cag     1005
 Leu Ser Arg Val Pro Glu Gln Glu Glu Asp Arg Thr Val Ser Leu Gln
         245                 250                 255

 aat gcc gca gcc atc tat gac ctc ctg agc atc acg ttg ggc aga agg     1053
 Asn Ala Ala Ala Ile Tyr Asp Leu Leu Ser Ile Thr Leu Gly Arg Arg
     260                 265                 270

 gga cag tac gtc atg ctc tcg gag tgc ctg gag cga gcc atg aag ttt     1101
 Gly Gln Tyr Val Met Leu Ser Glu Cys Leu Glu Arg Ala Met Lys Phe
 275                 280                 285                 290

 gcg ttt gga gaa ttt cac ctt tgg tac cag gtg gcc ctc tcc atg gtg     1149
 Ala Phe Gly Glu Phe His Leu Trp Tyr Gln Val Ala Leu Ser Met Val
                 295                 300                 305

 gct tgt ggg aag tca gcc tac gct gtg tcc ctg ctg cgg gag tgt gtg     1197
 Ala Cys Gly Lys Ser Ala Tyr Ala Val Ser Leu Leu Arg Glu Cys Val
             310                 315                 320

 aag ttg cgg ccc tcg gac ccc acc gtg ccc ctg atg gcc gcg aag gtc     1245
 Lys Leu Arg Pro Ser Asp Pro Thr Val Pro Leu Met Ala Ala Lys Val
         325                 330                 335

 tgc atc ggg tcc ctt cgc tgg cta gag gaa gca gag cac ttt gcc atg     1293
 Cys Ile Gly Ser Leu Arg Trp Leu Glu Glu Ala Glu His Phe Ala Met
     340                 345                 350

 atg gtg atc agc ctc gga gag gaa gcc ggg gag ttc ctc ccc aag ggc     1341
 Met Val Ile Ser Leu Gly Glu Glu Ala Gly Glu Phe Leu Pro Lys Gly
 355                 360                 365                 370

 tac ctg gct ctg ggt ctc acc tat agc ctg cag gcc acc gac gcc acc     1389
 Tyr Leu Ala Leu Gly Leu Thr Tyr Ser Leu Gln Ala Thr Asp Ala Thr
                 375                 380                 385

 ctg aag tcc aag caa gat gaa ttg cac cgg aag gca ctg cag acg ctg     1437
 Leu Lys Ser Lys Gln Asp Glu Leu His Arg Lys Ala Leu Gln Thr Leu
             390                 395                 400

 gag agg gct cag cag ctg gcg ccc agt gac ccc cag gtc atc ctc tat     1485
 Glu Arg Ala Gln Gln Leu Ala Pro Ser Asp Pro Gln Val Ile Leu Tyr
         405                 410                 415

 gtc tcg ctg cag ctg gcc ctc gtc cga cag atc tcc agt gcc atg gag     1533
 Val Ser Leu Gln Leu Ala Leu Val Arg Gln Ile Ser Ser Ala Met Glu
     420                 425                 430

 cag ctg cag gag gcc ctg aag gta cgc aag gat gat gcc cac gcc ctc     1581
 Gln Leu Gln Glu Ala Leu Lys Val Arg Lys Asp Asp Ala His Ala Leu
 435                 440                 445                 450

 cac ctg ctg gca ctg ctc ttc tct gcc cag aag cac cac cag cat gcc     1629
 His Leu Leu Ala Leu Leu Phe Ser Ala Gln Lys His His Gln His Ala
                 455                 460                 465

 ctg gat gtt gtc aac atg gcc atc acc gag cac cct gag aac ttc aac     1677
 Leu Asp Val Val Asn Met Ala Ile Thr Glu His Pro Glu Asn Phe Asn
             470                 475                 480

 ctg atg ttc acc aag gtg aag ctg gag cag gtg ctg aaa ggc cca gag     1725
 Leu Met Phe Thr Lys Val Lys Leu Glu Gln Val Leu Lys Gly Pro Glu
         485                 490                 495

 gaa gcc ctc gtg acc tgc aga caa gtg ctg agg ctg tgg cag acc ctg     1773
 Glu Ala Leu Val Thr Cys Arg Gln Val Leu Arg Leu Trp Gln Thr Leu
     500                 505                 510

 tac agc ttc tcc cag ctg gga ggc cta gaa aag gat ggc agc ttc ggt     1821
 Tyr Ser Phe Ser Gln Leu Gly Gly Leu Glu Lys Asp Gly Ser Phe Gly
 515                 520                 525                 530

 gag ggc ctc acc atg aag aag cag agt ggc atg cac ctg act ttg cct     1869
 Glu Gly Leu Thr Met Lys Lys Gln Ser Gly Met His Leu Thr Leu Pro
                 535                 540                 545

 gat gcc cat gat gca gac tct ggc tcc cgg cgg gct tcg tcc atc gcc     1917
 Asp Ala His Asp Ala Asp Ser Gly Ser Arg Arg Ala Ser Ser Ile Ala
             550                 555                 560

 gcc tcc cgg ctg gag gag gcc atg tca gag ctg act atg ccc tct tcg     1965
 Ala Ser Arg Leu Glu Glu Ala Met Ser Glu Leu Thr Met Pro Ser Ser
         565                 570                 575

 gtc ctg aag cag ggc ccc atg cag ctg tgg acc acg ctg gaa cag atc     2013
 Val Leu Lys Gln Gly Pro Met Gln Leu Trp Thr Thr Leu Glu Gln Ile
     580                 585                 590

 tgg ctg cag gct gct gag ctg ttc atg gag cag cag cac ctc aag gaa     2061
 Trp Leu Gln Ala Ala Glu Leu Phe Met Glu Gln Gln His Leu Lys Glu
 595                 600                 605                 610

 gca ggt ttc tgc atc cag gag gcg gcg ggc ctc ttc ccc act tct cac     2109
 Ala Gly Phe Cys Ile Gln Glu Ala Ala Gly Leu Phe Pro Thr Ser His
                 615                 620                 625

 tca gta ctc tat atg cgg ggc cgg ctg gct gag gtg aag ggc aac ctg     2157
 Ser Val Leu Tyr Met Arg Gly Arg Leu Ala Glu Val Lys Gly Asn Leu
             630                 635                 640

 gag gag gcc aag cag ctg tac aag gag gcg ctc acg gtg aac cca gat     2205
 Glu Glu Ala Lys Gln Leu Tyr Lys Glu Ala Leu Thr Val Asn Pro Asp
         645                 650                 655

 ggc gtg cgc atc atg cat agc ctg ggt ctg atg ctg agt cgg ctg ggc     2253
 Gly Val Arg Ile Met His Ser Leu Gly Leu Met Leu Ser Arg Leu Gly
     660                 665                 670

 cac aag agc ttg gcc cag aag gtg ctt cgt gat gcc gtg gag agg cag     2301
 His Lys Ser Leu Ala Gln Lys Val Leu Arg Asp Ala Val Glu Arg Gln
 675                 680                 685                 690

 agt acg tgc cac gag gcg tgg cag ggc ctg ggc gag gtg ctg cag gcc     2349
 Ser Thr Cys His Glu Ala Trp Gln Gly Leu Gly Glu Val Leu Gln Ala
                 695                 700                 705

 cag ggc cag aac gag gct gcc gtt gac tgc ttc ctc acc gcc ctt gag     2397
 Gln Gly Gln Asn Glu Ala Ala Val Asp Cys Phe Leu Thr Ala Leu Glu
             710                 715                 720

 ctg gag gcc agc agc cct gta ctg ccc ttc tcc atc atc ccc aga gag     2445
 Leu Glu Ala Ser Ser Pro Val Leu Pro Phe Ser Ile Ile Pro Arg Glu
         725                 730                 735

 ctc tga cgacgctgca gccgcaggga gggaggggct ggccagaggg agaggcagca      2501
 Leu 






      <210> 461
      <211> 371
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (122)..(301)

      <400> 461
 gagctatgac gtcgcatgca cgcgtacgta agcttggatc ctctagagcg gccgctacta     60

 ctacgaaatt cgcggcccgt cgaccgcgcg gtgtggtggc agcaggcgca ccagcctcga    120

 a    atg cag aac gac gcc ggc gag ttc gtg gac ctg tac gtg ccg cgg     166
      Met Gln Asn Asp Ala Gly Glu Phe Val Asp Leu Tyr Val Pro Arg
        1               5                  10                  15

 aaa tgc tcc gct agc aat cgc atc atc ggt gcc aag gac cac gca tcc      214
 Lys Cys Ser Ala Ser Asn Arg Ile Ile Gly Ala Lys Asp His Ala Ser
                  20                  25                  30

 atc cag atg aac gtg gcc gag ggt gag tca gat gat tcc att ctc cga      262
 Ile Gln Met Asn Val Ala Glu Gly Glu Ser Asp Asp Ser Ile Leu Arg
              35                  40                  45

 ttg gcc aag gcc gat ggc atc gtc tca aag aac ttt tga ctggagagaa       311
 Leu Ala Lys Ala Asp Gly Ile Val Ser Lys Asn Phe 
          50                  55

 tcacagatgt ggaatatttg tcataaataa ataatgaaaa cctaaaaaga aaaaaaaaaa    371




      <210> 462
      <211> 6684
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (35)..(6634)

      <400> 462
 accgcgtccg gatttcccgg gtcgacgatt tcgt    atg gtt atc agg tgc ctt      52
                                          Met Val Ile Arg Cys Leu
                                            1               5

 cca cag agg gaa ctg gac tgc gac aga ggg aac tgg act gcg acg tct      100
 Pro Gln Arg Glu Leu Asp Cys Asp Arg Gly Asn Trp Thr Ala Thr Ser
              10                  15                  20

 gct gaa ctc acg gga atc aaa tgg cgt agg tac aat ttt gga ggg cat      148
 Ala Glu Leu Thr Gly Ile Lys Trp Arg Arg Tyr Asn Phe Gly Gly His
          25                  30                  35

 ggg gac tgt gga ccc ata att tca gcc cca gcc caa gat gat cca att      196
 Gly Asp Cys Gly Pro Ile Ile Ser Ala Pro Ala Gln Asp Asp Pro Ile
      40                  45                  50

 ctg tta agt ttc atc cgc tgt ctg caa gct aac ctg ctt tgt gta tgg      244
 Leu Leu Ser Phe Ile Arg Cys Leu Gln Ala Asn Leu Leu Cys Val Trp
  55                  60                  65                  70

 cgt cgt gat gtc aaa cca gat tgc aaa gag tta tgg ata ttc tgg tgg      292
 Arg Arg Asp Val Lys Pro Asp Cys Lys Glu Leu Trp Ile Phe Trp Trp
                  75                  80                  85

 gga gat gaa ccc aac cta gtg ggt gta ata cat cat gaa ctg cag gtt      340
 Gly Asp Glu Pro Asn Leu Val Gly Val Ile His His Glu Leu Gln Val
              90                  95                 100

 gtg gaa gaa gga ctc tgg gaa aat ggc ctt tcc tat gaa tgt agg acg      388
 Val Glu Glu Gly Leu Trp Glu Asn Gly Leu Ser Tyr Glu Cys Arg Thr
         105                 110                 115

 ctg ctc ttc aaa gcg atc cac aat ctg tta gaa agg tgc cta atg gat      436
 Leu Leu Phe Lys Ala Ile His Asn Leu Leu Glu Arg Cys Leu Met Asp
     120                 125                 130

 aag aac ttc gtt agg att ggg aaa tgg ttt gtc cga ccc tac gaa aag      484
 Lys Asn Phe Val Arg Ile Gly Lys Trp Phe Val Arg Pro Tyr Glu Lys
 135                 140                 145                 150

 gat gaa aag cca gtc aac aaa agt gag cat ttg tcc tgt gct ttc aca      532
 Asp Glu Lys Pro Val Asn Lys Ser Glu His Leu Ser Cys Ala Phe Thr
                 155                 160                 165

 ttc ttt ctg cat gga gaa agt aat gta tgc aca agt gtg gag att gcc      580
 Phe Phe Leu His Gly Glu Ser Asn Val Cys Thr Ser Val Glu Ile Ala
             170                 175                 180

 cag cac cag cca att tat ttg atc aat gag gag cat ata cac atg gct      628
 Gln His Gln Pro Ile Tyr Leu Ile Asn Glu Glu His Ile His Met Ala
         185                 190                 195

 cag tct tca cct gca cca ttt caa gta ctg gta agt cct tat ggc tta      676
 Gln Ser Ser Pro Ala Pro Phe Gln Val Leu Val Ser Pro Tyr Gly Leu
     200                 205                 210

 aat ggg acg cta aca ggc caa gca tac aag atg tca gac cca gcc act      724
 Asn Gly Thr Leu Thr Gly Gln Ala Tyr Lys Met Ser Asp Pro Ala Thr
 215                 220                 225                 230

 cgt aag ttg att gag gaa tgg cag tat ttc tac ccg atg gtg cta aaa      772
 Arg Lys Leu Ile Glu Glu Trp Gln Tyr Phe Tyr Pro Met Val Leu Lys
                 235                 240                 245

 aaa aaa gaa gaa tcg aaa gag gaa gac gag ttg gga tat gat gat gat      820
 Lys Lys Glu Glu Ser Lys Glu Glu Asp Glu Leu Gly Tyr Asp Asp Asp
             250                 255                 260

 ttc cct gtg gca gtt gaa gta att gtt gca ttt gtt ttg atc tct cag      868
 Phe Pro Val Ala Val Glu Val Ile Val Ala Phe Val Leu Ile Ser Gln
         265                 270                 275

 aat gac atc ccg gtt cct cag agt gtt gcc agt gct gga ggc cac att      916
 Asn Asp Ile Pro Val Pro Gln Ser Val Ala Ser Ala Gly Gly His Ile
     280                 285                 290

 gca gtt ggg cag caa ggg ctt ggt agt gtg aag gac cca agt aac tgt      964
 Ala Val Gly Gln Gln Gly Leu Gly Ser Val Lys Asp Pro Ser Asn Cys
 295                 300                 305                 310

 ggg atg cct ctg acc cct ccc acc tct cca gaa cag gct atc cta ggt     1012
 Gly Met Pro Leu Thr Pro Pro Thr Ser Pro Glu Gln Ala Ile Leu Gly
                 315                 320                 325

 gag agt gga ggt atg cag agt gct gcc agt cac ctg gtt tcc caa gat     1060
 Glu Ser Gly Gly Met Gln Ser Ala Ala Ser His Leu Val Ser Gln Asp
             330                 335                 340

 gga ggg atg ata acg atg cac agt cca aag aga tcg ggg aag att cct     1108
 Gly Gly Met Ile Thr Met His Ser Pro Lys Arg Ser Gly Lys Ile Pro
         345                 350                 355

 cca aaa ctc cac aat cat atg gtc cat cga gtc tgg aag gaa tgc atc     1156
 Pro Lys Leu His Asn His Met Val His Arg Val Trp Lys Glu Cys Ile
     360                 365                 370

 ctc aac aga acc cag tcc aag agg agc caa atg tca act cca act ctt     1204
 Leu Asn Arg Thr Gln Ser Lys Arg Ser Gln Met Ser Thr Pro Thr Leu
 375                 380                 385                 390

 gaa gaa gag cct gct agc aat cct gct act tgg gat ttt gtg gat cca     1252
 Glu Glu Glu Pro Ala Ser Asn Pro Ala Thr Trp Asp Phe Val Asp Pro
                 395                 400                 405

 acc caa aga gtc agc tgt tct tgt tcc agg cat aag ctt tta aaa cgt     1300
 Thr Gln Arg Val Ser Cys Ser Cys Ser Arg His Lys Leu Leu Lys Arg
             410                 415                 420

 tgt gca gtc ggg ccc aat cga cct ccc aca gta tct caa cca ggg ttc     1348
 Cys Ala Val Gly Pro Asn Arg Pro Pro Thr Val Ser Gln Pro Gly Phe
         425                 430                 435

 agt gca gga cca tca tca tct tca tct tta cca cct cct gct tct tct     1396
 Ser Ala Gly Pro Ser Ser Ser Ser Ser Leu Pro Pro Pro Ala Ser Ser
     440                 445                 450

 aag cac aaa aca gca gaa aga cag gaa aaa gga gac aag ctg caa aag     1444
 Lys His Lys Thr Ala Glu Arg Gln Glu Lys Gly Asp Lys Leu Gln Lys
 455                 460                 465                 470

 aga ccc tta ata cca ttt cac cat agg ccc tct gtg gcc gaa gaa tta     1492
 Arg Pro Leu Ile Pro Phe His His Arg Pro Ser Val Ala Glu Glu Leu
                 475                 480                 485

 tgc atg gag caa gat aca cca gga cag aaa cta ggg ttg gca ggg ata     1540
 Cys Met Glu Gln Asp Thr Pro Gly Gln Lys Leu Gly Leu Ala Gly Ile
             490                 495                 500

 gac tcc tcc tta gag gtg tct agc agt agg aaa tat gat aag caa atg     1588
 Asp Ser Ser Leu Glu Val Ser Ser Ser Arg Lys Tyr Asp Lys Gln Met
         505                 510                 515

 gcc gtg cct tcc aga aat aca agc aag caa atg aat ctg aat cct atg     1636
 Ala Val Pro Ser Arg Asn Thr Ser Lys Gln Met Asn Leu Asn Pro Met
     520                 525                 530

 gat tca cct cat tcc cct ata tcc cct ctg cca cca aca ctc agc cct     1684
 Asp Ser Pro His Ser Pro Ile Ser Pro Leu Pro Pro Thr Leu Ser Pro
 535                 540                 545                 550

 cag cca cga ggt cag gaa aca gag agt ttg gac cca cca tcg gtc cct     1732
 Gln Pro Arg Gly Gln Glu Thr Glu Ser Leu Asp Pro Pro Ser Val Pro
                 555                 560                 565

 gtg aat cca gcc ctt tat gga aat gga cta gaa ctc cag cag ttg tct     1780
 Val Asn Pro Ala Leu Tyr Gly Asn Gly Leu Glu Leu Gln Gln Leu Ser
             570                 575                 580

 act ctg gat gac aga act gtc ctc gta ggc caa aga ctg cct ctc atg     1828
 Thr Leu Asp Asp Arg Thr Val Leu Val Gly Gln Arg Leu Pro Leu Met
         585                 590                 595

 gca gag gtc agc gag aca gcc tta tat tgt ggg att agg ccc tcg aac     1876
 Ala Glu Val Ser Glu Thr Ala Leu Tyr Cys Gly Ile Arg Pro Ser Asn
     600                 605                 610

 ccg gag tca tca gaa aag tgg tgg cat agt tat cgt ctc cca ccc agt     1924
 Pro Glu Ser Ser Glu Lys Trp Trp His Ser Tyr Arg Leu Pro Pro Ser
 615                 620                 625                 630

 gat gat gct gag ttc agg cct cca gag ctc cag ggt gag aga tgt gat     1972
 Asp Asp Ala Glu Phe Arg Pro Pro Glu Leu Gln Gly Glu Arg Cys Asp
                 635                 640                 645

 gcc aaa atg gag gta aac tca gag agc act gca ttg caa aga ctc tta     2020
 Ala Lys Met Glu Val Asn Ser Glu Ser Thr Ala Leu Gln Arg Leu Leu
             650                 655                 660

 gca caa cct aac aaa cgg ttt aaa atc tgg caa gac aaa cag ccc cag     2068
 Ala Gln Pro Asn Lys Arg Phe Lys Ile Trp Gln Asp Lys Gln Pro Gln
         665                 670                 675

 ttg cag cca ctc cac ttc ctt gac cca ttg cct cta tca caa caa cct     2116
 Leu Gln Pro Leu His Phe Leu Asp Pro Leu Pro Leu Ser Gln Gln Pro
     680                 685                 690

 gga gac agt ttg gga gaa gtg aat gac cca tat acc ttt gaa gat ggt     2164
 Gly Asp Ser Leu Gly Glu Val Asn Asp Pro Tyr Thr Phe Glu Asp Gly
 695                 700                 705                 710

 gac ata aaa tac atc ttt aca gcc aac aag aaa tgc aaa caa ggg acg     2212
 Asp Ile Lys Tyr Ile Phe Thr Ala Asn Lys Lys Cys Lys Gln Gly Thr
                 715                 720                 725

 gag aaa gat tcc ctg aaa aag aat aag tca gag gat gga ttt ggt acc     2260
 Glu Lys Asp Ser Leu Lys Lys Asn Lys Ser Glu Asp Gly Phe Gly Thr
             730                 735                 740

 aag gat gtc act aca cca ggt cat tcc acg ccg gtg cct gat ggg aaa     2308
 Lys Asp Val Thr Thr Pro Gly His Ser Thr Pro Val Pro Asp Gly Lys
         745                 750                 755

 aat gcc atg tct att ttc agt tct gct act aaa aca gat gtc cgg cag     2356
 Asn Ala Met Ser Ile Phe Ser Ser Ala Thr Lys Thr Asp Val Arg Gln
     760                 765                 770

 gat aat gct gct ggc aga gct ggc tcc agt agc ctt aca cag gta aca     2404
 Asp Asn Ala Ala Gly Arg Ala Gly Ser Ser Ser Leu Thr Gln Val Thr
 775                 780                 785                 790

 gat ttg gca cct tcc ctg cat gac tta gac aac atc ttt gat aat tct     2452
 Asp Leu Ala Pro Ser Leu His Asp Leu Asp Asn Ile Phe Asp Asn Ser
                 795                 800                 805

 gat gac gac gaa ctt ggg gct gta tca cct gct ctg cgc tca tca aaa     2500
 Asp Asp Asp Glu Leu Gly Ala Val Ser Pro Ala Leu Arg Ser Ser Lys
             810                 815                 820

 atg cct gca gtt ggg aca gaa gac cga cct ctt ggg aag gat gga aga     2548
 Met Pro Ala Val Gly Thr Glu Asp Arg Pro Leu Gly Lys Asp Gly Arg
         825                 830                 835

 gct gct gtt cct tat cca cca aca gtt gca gac ttg caa agg atg ttt     2596
 Ala Ala Val Pro Tyr Pro Pro Thr Val Ala Asp Leu Gln Arg Met Phe
     840                 845                 850

 ccc act cca cca tct ttg gaa cag cat cct gca ttt tct cct gtg atg     2644
 Pro Thr Pro Pro Ser Leu Glu Gln His Pro Ala Phe Ser Pro Val Met
 855                 860                 865                 870

 aat tat aaa gat ggg atc agc tca gag aca gtg aca gca tta ggc atg     2692
 Asn Tyr Lys Asp Gly Ile Ser Ser Glu Thr Val Thr Ala Leu Gly Met
                 875                 880                 885

 atg gag agc cct atg gtc agt atg gtt tca aca caa ctc aca gaa ttc     2740
 Met Glu Ser Pro Met Val Ser Met Val Ser Thr Gln Leu Thr Glu Phe
             890                 895                 900

 aaa atg gaa gtg gaa gat gga tta gga agt ccc aag ccc gag gaa att     2788
 Lys Met Glu Val Glu Asp Gly Leu Gly Ser Pro Lys Pro Glu Glu Ile
         905                 910                 915

 aag gac ttt tca tat gtg cac aaa gtt cca tcc ttt caa cct ttt gtg     2836
 Lys Asp Phe Ser Tyr Val His Lys Val Pro Ser Phe Gln Pro Phe Val
     920                 925                 930

 gga tcc tcc atg ttt gct cca ctg aag atg ttg ccg agc cat tgt ttg     2884
 Gly Ser Ser Met Phe Ala Pro Leu Lys Met Leu Pro Ser His Cys Leu
 935                 940                 945                 950

 cta cct ctg aag ata cct gat gcc tgt ctg ttt cgg cct tca tgg gca     2932
 Leu Pro Leu Lys Ile Pro Asp Ala Cys Leu Phe Arg Pro Ser Trp Ala
                 955                 960                 965

 att cct cct aaa att gaa caa ctg ccc atg ccc cct gca gcc act ttc     2980
 Ile Pro Pro Lys Ile Glu Gln Leu Pro Met Pro Pro Ala Ala Thr Phe
             970                 975                 980

 att aga gat ggc tac aat aac gtg cct agt gtt ggg agc cta gca gat     3028
 Ile Arg Asp Gly Tyr Asn Asn Val Pro Ser Val Gly Ser Leu Ala Asp
         985                 990                 995

 cca gac tat ctg aac aca cca cag atg aac aca ccc gtg acg ttg aac     3076
 Pro Asp Tyr Leu Asn Thr Pro Gln Met Asn Thr Pro Val Thr Leu Asn
    1000                1005                1010

 agc gct gcc cca gcc agc aat agt ggg gca gga gtc cta cca tct cca     3124
 Ser Ala Ala Pro Ala Ser Asn Ser Gly Ala Gly Val Leu Pro Ser Pro
1015                1020                1025                1030

 gca acc cct cgc ttc tct gtc ccc aca cca cga acc ccc agg acc cca     3172
 Ala Thr Pro Arg Phe Ser Val Pro Thr Pro Arg Thr Pro Arg Thr Pro
                1035                1040                1045

 aga act ccc aga ggt ggg ggc act gcc agt ggt caa ggg tct gtt aag     3220
 Arg Thr Pro Arg Gly Gly Gly Thr Ala Ser Gly Gln Gly Ser Val Lys
            1050                1055                1060

 tat gat agc acc gat caa gga tca cca gcc tcc acc ccc tct act aca     3268
 Tyr Asp Ser Thr Asp Gln Gly Ser Pro Ala Ser Thr Pro Ser Thr Thr
        1065                1070                1075

 cgg ccc ctc aac tct gtg gag ccc gcc acc atg cag cca att ccc gaa     3316
 Arg Pro Leu Asn Ser Val Glu Pro Ala Thr Met Gln Pro Ile Pro Glu
    1080                1085                1090

 gcc cac agc ctc tat gtt acc ctg att ctc tcc gat tcc gtg atg aat     3364
 Ala His Ser Leu Tyr Val Thr Leu Ile Leu Ser Asp Ser Val Met Asn
1095                1100                1105                1110

 atc ttt aaa gac aga aac ttt gac agc tgt tgc atc tgt gcc tgc aac     3412
 Ile Phe Lys Asp Arg Asn Phe Asp Ser Cys Cys Ile Cys Ala Cys Asn
                1115                1120                1125

 atg aac atc aaa ggg gcg gat gtc ggg ctt tac atc ccc gat tct tcc     3460
 Met Asn Ile Lys Gly Ala Asp Val Gly Leu Tyr Ile Pro Asp Ser Ser
            1130                1135                1140

 aat gag gac cag tac cgc tgt acc tgt ggg ttt agt gcg att atg aac     3508
 Asn Glu Asp Gln Tyr Arg Cys Thr Cys Gly Phe Ser Ala Ile Met Asn
        1145                1150                1155

 cgc aaa ctt ggc tac aat tca gga ctc ttc ctt gaa gat gag ttg gat     3556
 Arg Lys Leu Gly Tyr Asn Ser Gly Leu Phe Leu Glu Asp Glu Leu Asp
    1160                1165                1170

 att ttt ggg aag aat tct gat att ggt cag gct gca gag agg cgc tta     3604
 Ile Phe Gly Lys Asn Ser Asp Ile Gly Gln Ala Ala Glu Arg Arg Leu
1175                1180                1185                1190

 atg atg tgt cag tcc acc ttc ctt cct cag gtg gaa gga acc aaa aaa     3652
 Met Met Cys Gln Ser Thr Phe Leu Pro Gln Val Glu Gly Thr Lys Lys
                1195                1200                1205

 ccc cag gag cca ccc ata agc ctt ctc ctc ctc ctc cag aat caa cac     3700
 Pro Gln Glu Pro Pro Ile Ser Leu Leu Leu Leu Leu Gln Asn Gln His
            1210                1215                1220

 aca caa cct ttt gct tca ctg aat ttc ctg gac tac att tcc tct aac     3748
 Thr Gln Pro Phe Ala Ser Leu Asn Phe Leu Asp Tyr Ile Ser Ser Asn
        1225                1230                1235

 aat cgc caa act ctt ccc tgt gta agc tgg agt tat gac cgg gtg caa     3796
 Asn Arg Gln Thr Leu Pro Cys Val Ser Trp Ser Tyr Asp Arg Val Gln
    1240                1245                1250

 gca gat aat aat gat tac tgg acg gaa tgc ttt aat gcg ttg gag cag     3844
 Ala Asp Asn Asn Asp Tyr Trp Thr Glu Cys Phe Asn Ala Leu Glu Gln
1255                1260                1265                1270

 ggg cgg cag tat gtg gat aac ccc act ggt gga aaa gtg gac gaa gct     3892
 Gly Arg Gln Tyr Val Asp Asn Pro Thr Gly Gly Lys Val Asp Glu Ala
                1275                1280                1285

 ctg gtg aga agt gcc act gtg cac tct tgg cct cac agc aat gtg ctg     3940
 Leu Val Arg Ser Ala Thr Val His Ser Trp Pro His Ser Asn Val Leu
            1290                1295                1300

 gac atc agc atg ctc tcc tcc cag gat gtg gtt cgt atg ctg ttg tcc     3988
 Asp Ile Ser Met Leu Ser Ser Gln Asp Val Val Arg Met Leu Leu Ser
        1305                1310                1315

 ctg cag ccc ttt ctc caa gat gcc atc caa aag aag cgc acg ggc agg     4036
 Leu Gln Pro Phe Leu Gln Asp Ala Ile Gln Lys Lys Arg Thr Gly Arg
    1320                1325                1330

 acc tgg gag aac atc cag cat gtg cag gga cca ctc act tgg cag cag     4084
 Thr Trp Glu Asn Ile Gln His Val Gln Gly Pro Leu Thr Trp Gln Gln
1335                1340                1345                1350

 ttc cat aaa atg gca gga cgg gga acc tac ggt tcg gaa gaa tct cct     4132
 Phe His Lys Met Ala Gly Arg Gly Thr Tyr Gly Ser Glu Glu Ser Pro
                1355                1360                1365

 gag ccg ttg ccc atc ccc act ctg ctg gta ggc tat gac aag gat ttc     4180
 Glu Pro Leu Pro Ile Pro Thr Leu Leu Val Gly Tyr Asp Lys Asp Phe
            1370                1375                1380

 ctc acc atc tcg cca ttc tcc ttg ccg ttt tgg gag agg ctc ttg ttg     4228
 Leu Thr Ile Ser Pro Phe Ser Leu Pro Phe Trp Glu Arg Leu Leu Leu
        1385                1390                1395

 gac cca tat ggg ggc cac cgt gat gtt gcc tat att gtg gtg tgt cca     4276
 Asp Pro Tyr Gly Gly His Arg Asp Val Ala Tyr Ile Val Val Cys Pro
    1400                1405                1410

 gaa aat gag gcc ttg ctc gaa gga gcc aaa act ttc ttc agg gac ttg     4324
 Glu Asn Glu Ala Leu Leu Glu Gly Ala Lys Thr Phe Phe Arg Asp Leu
1415                1420                1425                1430

 agt gct gta tac gag atg tgt agg ctt ggg cag cac aag ccc atc tgc     4372
 Ser Ala Val Tyr Glu Met Cys Arg Leu Gly Gln His Lys Pro Ile Cys
                1435                1440                1445

 aaa gtg cta cgt gac ggg atc atg cgc gtg gga aaa act gtg gca cag     4420
 Lys Val Leu Arg Asp Gly Ile Met Arg Val Gly Lys Thr Val Ala Gln
            1450                1455                1460

 aag ctg aca gat gag ctt gtg agt gag tgg ttt aac cag cct tgg agc     4468
 Lys Leu Thr Asp Glu Leu Val Ser Glu Trp Phe Asn Gln Pro Trp Ser
        1465                1470                1475

 ggc gag gag aat gac aat cat tcc aga ctc aaa ctt tat gcg caa gtt     4516
 Gly Glu Glu Asn Asp Asn His Ser Arg Leu Lys Leu Tyr Ala Gln Val
    1480                1485                1490

 tgc cgc cat cac cta gca cct tat tta gcc act ctg cag ctt gat agc     4564
 Cys Arg His His Leu Ala Pro Tyr Leu Ala Thr Leu Gln Leu Asp Ser
1495                1500                1505                1510

 agc cta ttg ata cca cct aaa tac cag acc cca cca gca gca gca cag     4612
 Ser Leu Leu Ile Pro Pro Lys Tyr Gln Thr Pro Pro Ala Ala Ala Gln
                1515                1520                1525

 gga caa gct acg cca ggg aat gct ggg ccc tta gct cca aat gga tca     4660
 Gly Gln Ala Thr Pro Gly Asn Ala Gly Pro Leu Ala Pro Asn Gly Ser
            1530                1535                1540

 gca gct ccc cca gct ggc agt gca ttt aat ccc acc tcg aat agt agt     4708
 Ala Ala Pro Pro Ala Gly Ser Ala Phe Asn Pro Thr Ser Asn Ser Ser
        1545                1550                1555

 tct aca aat cct gca gca agt agt tct gca tct ggt tcc tct gtg cca     4756
 Ser Thr Asn Pro Ala Ala Ser Ser Ser Ala Ser Gly Ser Ser Val Pro
    1560                1565                1570

 ccg gtc tca tcg tct gcc tct gct cct ggt att agc cag ata agc act     4804
 Pro Val Ser Ser Ser Ala Ser Ala Pro Gly Ile Ser Gln Ile Ser Thr
1575                1580                1585                1590

 acc tct tct tca gga ttc agt ggt agt gtt gga ggg cag aac ccc agc     4852
 Thr Ser Ser Ser Gly Phe Ser Gly Ser Val Gly Gly Gln Asn Pro Ser
                1595                1600                1605

 act ggg ggc att tct gcg gat aga acg caa ggg aac ata ggc tgt ggt     4900
 Thr Gly Gly Ile Ser Ala Asp Arg Thr Gln Gly Asn Ile Gly Cys Gly
            1610                1615                1620

 gga gac act gac cct ggg cag agc tct tct cag ccc tca cag gat gga     4948
 Gly Asp Thr Asp Pro Gly Gln Ser Ser Ser Gln Pro Ser Gln Asp Gly
        1625                1630                1635

 caa gag agt gtt aca gaa agg gag aga ata gga att ccc acg gag cct     4996
 Gln Glu Ser Val Thr Glu Arg Glu Arg Ile Gly Ile Pro Thr Glu Pro
    1640                1645                1650

 gac tct gca gac agc cat gcc cac cct cca gct gtt gtc att tac atg     5044
 Asp Ser Ala Asp Ser His Ala His Pro Pro Ala Val Val Ile Tyr Met
1655                1660                1665                1670

 gtg gac ccg ttc acg tat gct gca gag gag gac tcc act tct ggg aac     5092
 Val Asp Pro Phe Thr Tyr Ala Ala Glu Glu Asp Ser Thr Ser Gly Asn
                1675                1680                1685

 ttt tgg ctg ttg agc ttg atg cgc tgc tac aca gaa atg ctg gat aat     5140
 Phe Trp Leu Leu Ser Leu Met Arg Cys Tyr Thr Glu Met Leu Asp Asn
            1690                1695                1700

 tta cct gag cat atg aga aat tct ttc att ctc cag att gtg cct tgc     5188
 Leu Pro Glu His Met Arg Asn Ser Phe Ile Leu Gln Ile Val Pro Cys
        1705                1710                1715

 cag tac atg ctg cag aca atg aag gat gag caa gtt ttc tac att caa     5236
 Gln Tyr Met Leu Gln Thr Met Lys Asp Glu Gln Val Phe Tyr Ile Gln
    1720                1725                1730

 tac ttg aag tcc atg gca ttt tca gtg tac tgc cag tgc agg cga cca     5284
 Tyr Leu Lys Ser Met Ala Phe Ser Val Tyr Cys Gln Cys Arg Arg Pro
1735                1740                1745                1750

 ctg cct aca cag atc cac att aaa tcc ctc acg gga ttt ggg cct gca     5332
 Leu Pro Thr Gln Ile His Ile Lys Ser Leu Thr Gly Phe Gly Pro Ala
                1755                1760                1765

 gcc agc att gag atg acc ctc aag aac cct gag cgg ccc agc cca atc     5380
 Ala Ser Ile Glu Met Thr Leu Lys Asn Pro Glu Arg Pro Ser Pro Ile
            1770                1775                1780

 cag ctt tac tcc cct ccc ttt ata ttg gcc cca atc aaa gac aag cag     5428
 Gln Leu Tyr Ser Pro Pro Phe Ile Leu Ala Pro Ile Lys Asp Lys Gln
        1785                1790                1795

 aca gag ctg gga gag acg ttt ggt gag gcg agc cag aaa tac aat gtg     5476
 Thr Glu Leu Gly Glu Thr Phe Gly Glu Ala Ser Gln Lys Tyr Asn Val
    1800                1805                1810

 ctc ttc gtg ggc tat tgt ctg tct cac gac cag cgc tgg ctt ttg gct     5524
 Leu Phe Val Gly Tyr Cys Leu Ser His Asp Gln Arg Trp Leu Leu Ala
1815                1820                1825                1830

 tcc tgc act gac ctc cat ggg gaa tta tta gag acc tgc gtt gta aat     5572
 Ser Cys Thr Asp Leu His Gly Glu Leu Leu Glu Thr Cys Val Val Asn
                1835                1840                1845

 att gct tta cca aac agg tca cgg agg agt aaa gta tct gca cgt aaa     5620
 Ile Ala Leu Pro Asn Arg Ser Arg Arg Ser Lys Val Ser Ala Arg Lys
            1850                1855                1860

 att gga cta cag aag tta tgg gag tgg tgc ata ggg att gtc caa atg     5668
 Ile Gly Leu Gln Lys Leu Trp Glu Trp Cys Ile Gly Ile Val Gln Met
        1865                1870                1875

 aca tct cta ccc tgg aga gtt gta atc ggg cga ctt ggg cgt ctt ggc     5716
 Thr Ser Leu Pro Trp Arg Val Val Ile Gly Arg Leu Gly Arg Leu Gly
    1880                1885                1890

 cat ggg gag ctt aaa gat tgg agt atc ctc ctt gga gaa tgt tca cta     5764
 His Gly Glu Leu Lys Asp Trp Ser Ile Leu Leu Gly Glu Cys Ser Leu
1895                1900                1905                1910

 cag aca atc agc aaa aag ctc aag gat gtg tgc cgg atg tgt gga atc     5812
 Gln Thr Ile Ser Lys Lys Leu Lys Asp Val Cys Arg Met Cys Gly Ile
                1915                1920                1925

 tct gcc gca gac tct cct tct atc ctt agt gcc tgc ctg gtt gcc atg     5860
 Ser Ala Ala Asp Ser Pro Ser Ile Leu Ser Ala Cys Leu Val Ala Met
            1930                1935                1940

 gag ccc cag ggg tcc ttt gta gtg atg cca gat gct gtc aca atg ggc     5908
 Glu Pro Gln Gly Ser Phe Val Val Met Pro Asp Ala Val Thr Met Gly
        1945                1950                1955

 tct gtt ttt ggc cga agt act gca ctg aac atg cag tca tct cag ctc     5956
 Ser Val Phe Gly Arg Ser Thr Ala Leu Asn Met Gln Ser Ser Gln Leu
    1960                1965                1970

 aac acc cct caa gat gct tct tgt aca cac atc ttg gtg ttc cca aca     6004
 Asn Thr Pro Gln Asp Ala Ser Cys Thr His Ile Leu Val Phe Pro Thr
1975                1980                1985                1990

 tca tca acc atc cag gtg gct cca gcc aac tac ccc aat gaa gat ggg     6052
 Ser Ser Thr Ile Gln Val Ala Pro Ala Asn Tyr Pro Asn Glu Asp Gly
                1995                2000                2005

 ttt agc ccc aac aat gat gat atg ttt gtt gac ctt cca ttc cca gat     6100
 Phe Ser Pro Asn Asn Asp Asp Met Phe Val Asp Leu Pro Phe Pro Asp
            2010                2015                2020

 gat atg gac aat gat att ggc ata tta atg act ggg aac ctc cat tcc     6148
 Asp Met Asp Asn Asp Ile Gly Ile Leu Met Thr Gly Asn Leu His Ser
        2025                2030                2035

 tct ccc aac tct tcc cca gta ccc tcc cca ggc tct cct tct gga att     6196
 Ser Pro Asn Ser Ser Pro Val Pro Ser Pro Gly Ser Pro Ser Gly Ile
    2040                2045                2050

 ggt gtg ggc tct cac ttc cag cat agt cgg agc cag ggt gag cgt ctt     6244
 Gly Val Gly Ser His Phe Gln His Ser Arg Ser Gln Gly Glu Arg Leu
2055                2060                2065                2070

 ctt tct aga gaa gca cca gag gag cta aag cag cag ccc ctg gcc ctt     6292
 Leu Ser Arg Glu Ala Pro Glu Glu Leu Lys Gln Gln Pro Leu Ala Leu
                2075                2080                2085

 ggg tat ttt gta tca act gcc aaa gct gag aat ctt ccc cag tgg ttt     6340
 Gly Tyr Phe Val Ser Thr Ala Lys Ala Glu Asn Leu Pro Gln Trp Phe
            2090                2095                2100

 tgg tca tcg tgt ccc cag gct caa aac cag tgc cct ctc ttc tta aag     6388
 Trp Ser Ser Cys Pro Gln Ala Gln Asn Gln Cys Pro Leu Phe Leu Lys
        2105                2110                2115

 gct tcg ctg cat cac cac att tca gta gca cag aca gac gaa ctt ctg     6436
 Ala Ser Leu His His His Ile Ser Val Ala Gln Thr Asp Glu Leu Leu
    2120                2125                2130

 cct gcc agg aat tct cag cgg gtt cca cac cct ctt gac tcc aaa acc     6484
 Pro Ala Arg Asn Ser Gln Arg Val Pro His Pro Leu Asp Ser Lys Thr
2135                2140                2145                2150

 acg tcg gat gtt tta agg ttt gtt ttg gag cag tac aac gct ctg tcc     6532
 Thr Ser Asp Val Leu Arg Phe Val Leu Glu Gln Tyr Asn Ala Leu Ser
                2155                2160                2165

 tgg ctc acg tgc aat ccg gcc acc cag gac cgt act tcc tgc ctt ccc     6580
 Trp Leu Thr Cys Asn Pro Ala Thr Gln Asp Arg Thr Ser Cys Leu Pro
            2170                2175                2180

 gtc cac ttt gtg gtg ctc act cag ttg tac aat gcc atc atg aat ata     6628
 Val His Phe Val Val Leu Thr Gln Leu Tyr Asn Ala Ile Met Asn Ile
        2185                2190                2195

 ctt taa ttggaaaagc acttgttctc tctggctcag ttccttctcc ctgcaacctc      6684
 Leu 






      <210> 463
      <211> 451
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(267)

      <400> 463
  atg att acc tgt ctc ctc acg ggc atg ggc aaa aat gcc cat aag gca      48
  Met Ile Thr Cys Leu Leu Thr Gly Met Gly Lys Asn Ala His Lys Ala
    1               5                  10                  15

 gtt aat tct gag aaa ctt aga gaa att aca cag gag ccc cag aag aat       96
 Val Asn Ser Glu Lys Leu Arg Glu Ile Thr Gln Glu Pro Gln Lys Asn
              20                  25                  30

 cct gcc ctt ttc tta tca tgc atc act gaa gct atg cta aaa tat acc      144
 Pro Ala Leu Phe Leu Ser Cys Ile Thr Glu Ala Met Leu Lys Tyr Thr
          35                  40                  45

 aat ctg gac cca gaa tct aga gaa ggg caa act ttt ctc cac ctc caa      192
 Asn Leu Asp Pro Glu Ser Arg Glu Gly Gln Thr Phe Leu His Leu Gln
      50                  55                  60

 ttt att tcc caa tcc tcc cca gat atc cgg aaa ata att aca aaa ctt      240
 Phe Ile Ser Gln Ser Ser Pro Asp Ile Arg Lys Ile Ile Thr Lys Leu
  65                  70                  75                  80

 aga gga agg acc aat ttt aga cac tga ccaac actcatgctt gaatttaatt      292
 Arg Gly Arg Thr Asn Phe Arg His 
                  85

 gaaagttctc tcaccatgtt ctaccccctt acttccactc acataaagca agccccagat    352

 tggtttatag atggcagtgc atcagaaaac ccttccctcc aagcagggta tgctatcatt    412

 gagggatatc atgatgatac ccacctagaa gagtcgtag                           451




      <210> 464
      <211> 2316
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (236)..(2074)

      <400> 464
 gctcgcatgc ctgcccgccc gccagcctgc cgggtacggc cttttccgcc ggggcttcca     60

 ggtcaaagaa ttcgcctttg ccgctaccgc tttcttaccc tccgcacccg ttaagttctc    120

 cggtcgggcg gcagtctctg aacacttagc cgcgccatcc ggggtcacac cgcctggaag    180

 gaggtgacgg gggcggcgcg gggcgcggac actccccgct gagagtccgc ctgcc atg     238
                                                              Met
                                                                1

 gac tcg gaa tat tac agc ggc gac cag tca gat gat ggt ggt gct acc      286
 Asp Ser Glu Tyr Tyr Ser Gly Asp Gln Ser Asp Asp Gly Gly Ala Thr
               5                  10                  15

 cca gta cag gat gaa cgg gat tca ggg tca gac ggt gag gat gat gta      334
 Pro Val Gln Asp Glu Arg Asp Ser Gly Ser Asp Gly Glu Asp Asp Val
          20                  25                  30

 aat gag caa cac tcc gga tca gac act gga agt gta gaa cgt cat tca      382
 Asn Glu Gln His Ser Gly Ser Asp Thr Gly Ser Val Glu Arg His Ser
      35                  40                  45

 gag aat gaa act agt gac tca gaa aat gaa gag ctt ccc aaa ccc cga      430
 Glu Asn Glu Thr Ser Asp Ser Glu Asn Glu Glu Leu Pro Lys Pro Arg
  50                  55                  60                  65

 atc agt gat tcg gaa agt gag gat ccc cca agg aac cag gcc agt gat      478
 Ile Ser Asp Ser Glu Ser Glu Asp Pro Pro Arg Asn Gln Ala Ser Asp
                  70                  75                  80

 tcg gaa aat gag gag cta ccc aaa ccc cga gtc agt gac tct gag agt      526
 Ser Glu Asn Glu Glu Leu Pro Lys Pro Arg Val Ser Asp Ser Glu Ser
              85                  90                  95

 gag ggg cct cag aag ggg cct gcc agt gac tca gaa act gag gat gcg      574
 Glu Gly Pro Gln Lys Gly Pro Ala Ser Asp Ser Glu Thr Glu Asp Ala
         100                 105                 110

 tcc aga cac aaa cag aag cca gag tca gat gat gac agc gac agg gag      622
 Ser Arg His Lys Gln Lys Pro Glu Ser Asp Asp Asp Ser Asp Arg Glu
     115                 120                 125

 aat aag gga gag gat aca gaa atg cag aat gac tcc ttc cat tca gac      670
 Asn Lys Gly Glu Asp Thr Glu Met Gln Asn Asp Ser Phe His Ser Asp
 130                 135                 140                 145

 agc cat atg gac aga aaa aag ttt cac agt tct gat agt gag gag gaa      718
 Ser His Met Asp Arg Lys Lys Phe His Ser Ser Asp Ser Glu Glu Glu
                 150                 155                 160

 gaa cac aaa aag caa aaa atg gac agt gat gaa gat gaa aaa gag ggt      766
 Glu His Lys Lys Gln Lys Met Asp Ser Asp Glu Asp Glu Lys Glu Gly
             165                 170                 175

 gag gag gag aaa gta gcg aag aga aaa gct gct gtg ctt tct gat agt      814
 Glu Glu Glu Lys Val Ala Lys Arg Lys Ala Ala Val Leu Ser Asp Ser
         180                 185                 190

 gaa gat gaa gag aaa gca tca gca aag aag agt cgt gtt gtc tct gat      862
 Glu Asp Glu Glu Lys Ala Ser Ala Lys Lys Ser Arg Val Val Ser Asp
     195                 200                 205

 gca gat gac tct gac agt gat gct gta tca gac aag tca ggc aaa aga      910
 Ala Asp Asp Ser Asp Ser Asp Ala Val Ser Asp Lys Ser Gly Lys Arg
 210                 215                 220                 225

 gag aag acc ata gca tct gac agt gag gaa gaa gct ggg aaa gaa ttg      958
 Glu Lys Thr Ile Ala Ser Asp Ser Glu Glu Glu Ala Gly Lys Glu Leu
                 230                 235                 240

 tct gat aag aaa aat gaa gag aag gat ctg ttt ggg agt gac agt gag     1006
 Ser Asp Lys Lys Asn Glu Glu Lys Asp Leu Phe Gly Ser Asp Ser Glu
             245                 250                 255

 tca ggc aat gaa gaa gaa aat ctt att gca gac ata ttt gga gaa tct     1054
 Ser Gly Asn Glu Glu Glu Asn Leu Ile Ala Asp Ile Phe Gly Glu Ser
         260                 265                 270

 ggt gat gaa gag gaa gaa gaa ttt aca ggt ttt aac caa gaa gat ctg     1102
 Gly Asp Glu Glu Glu Glu Glu Phe Thr Gly Phe Asn Gln Glu Asp Leu
     275                 280                 285

 gaa gaa gaa aaa ggt gaa aca cag gta aaa gaa gca gaa gat tca gat     1150
 Glu Glu Glu Lys Gly Glu Thr Gln Val Lys Glu Ala Glu Asp Ser Asp
 290                 295                 300                 305

 tct gat gat aac ata aag aga gga aaa cat atg gac ttt ctg tca gat     1198
 Ser Asp Asp Asn Ile Lys Arg Gly Lys His Met Asp Phe Leu Ser Asp
                 310                 315                 320

 ttt gag atg atg ttg cag cga aaa aag agc atg agt ggc aag cgc aga     1246
 Phe Glu Met Met Leu Gln Arg Lys Lys Ser Met Ser Gly Lys Arg Arg
             325                 330                 335

 cgg aac cgc gat ggt ggc acc ttt att agt gat gca gac gac gtc gtg     1294
 Arg Asn Arg Asp Gly Gly Thr Phe Ile Ser Asp Ala Asp Asp Val Val
         340                 345                 350

 agt gcc atg atc gtc aag atg aat gaa gct gct gag gaa gac aga cag     1342
 Ser Ala Met Ile Val Lys Met Asn Glu Ala Ala Glu Glu Asp Arg Gln
     355                 360                 365

 ttg aac aat caa aaa aag cca gca ctg aaa aaa tta act tta ctg cct     1390
 Leu Asn Asn Gln Lys Lys Pro Ala Leu Lys Lys Leu Thr Leu Leu Pro
 370                 375                 380                 385

 gct gta gtt atg cac ctt aag aag cag gac ctt aaa gaa aca ttc att     1438
 Ala Val Val Met His Leu Lys Lys Gln Asp Leu Lys Glu Thr Phe Ile
                 390                 395                 400

 gac agt ggt gtg atg tct gcc atc aaa gaa tgg ctc tca cct cta cca     1486
 Asp Ser Gly Val Met Ser Ala Ile Lys Glu Trp Leu Ser Pro Leu Pro
             405                 410                 415

 gat agg agt ttg cct gca ctc aag atc cgg gag gag ctg ctg aag atc     1534
 Asp Arg Ser Leu Pro Ala Leu Lys Ile Arg Glu Glu Leu Leu Lys Ile
         420                 425                 430

 ctg caa gag ctg cct agt gtg agc cag gag acc ctg aag cat agt ggg     1582
 Leu Gln Glu Leu Pro Ser Val Ser Gln Glu Thr Leu Lys His Ser Gly
     435                 440                 445

 att gga cga gca gtg atg tat ctc tat aaa cac ccc aag gag tca agg     1630
 Ile Gly Arg Ala Val Met Tyr Leu Tyr Lys His Pro Lys Glu Ser Arg
 450                 455                 460                 465

 tct aac aag gac atg gca ggg aaa tta atc aat gag tgg tct agg cct     1678
 Ser Asn Lys Asp Met Ala Gly Lys Leu Ile Asn Glu Trp Ser Arg Pro
                 470                 475                 480

 ata ttt ggt ctt acc tca aac tac aaa gga atg aca aga gaa gaa agg     1726
 Ile Phe Gly Leu Thr Ser Asn Tyr Lys Gly Met Thr Arg Glu Glu Arg
             485                 490                 495

 gag cag aga gat cta gaa cag atg cct caa cga cga aga atg aac agc     1774
 Glu Gln Arg Asp Leu Glu Gln Met Pro Gln Arg Arg Arg Met Asn Ser
         500                 505                 510

 act ggt ggt cag aca ccc aga aga gac ctg gaa aag gtg ctg aca gga     1822
 Thr Gly Gly Gln Thr Pro Arg Arg Asp Leu Glu Lys Val Leu Thr Gly
     515                 520                 525

 gag gag aag gct ctt aga cct gga gat cct gga ttc tgt gcc cgt gca     1870
 Glu Glu Lys Ala Leu Arg Pro Gly Asp Pro Gly Phe Cys Ala Arg Ala
 530                 535                 540                 545

 agg gtc cca atg cct tca aac aag gac tat gtt gtc agg ccc aaa tgg     1918
 Arg Val Pro Met Pro Ser Asn Lys Asp Tyr Val Val Arg Pro Lys Trp
                 550                 555                 560

 aat gtg gaa atg gag tca tcc agg ttt cag gcg acc tcc aag aag ggt     1966
 Asn Val Glu Met Glu Ser Ser Arg Phe Gln Ala Thr Ser Lys Lys Gly
             565                 570                 575

 atc agt cga ctg gat aaa cag atg aga aag ttc aca gat ata agg aaa     2014
 Ile Ser Arg Leu Asp Lys Gln Met Arg Lys Phe Thr Asp Ile Arg Lys
         580                 585                 590

 aaa agc aga tct gca cac gca gtg aaa atc agc att gag ggc aac aaa     2062
 Lys Ser Arg Ser Ala His Ala Val Lys Ile Ser Ile Glu Gly Asn Lys
     595                 600                 605

 atg cca ttg tga cct tgcctggaat gtgtccccat ctctactcta agaaatgcgc     2117
 Met Pro Leu 
 610

 aatggactct ttggagaaag aagatatttt aaaacatttt tagtgtgtct gtaaatggtt   2177

 cagcgtgtat cagatgttgt cataggactc acatttctct cagttatatt taaaaccgtt   2237

 gtgtactttg tacaaaggaa tactagtcat acttctataa actttacaca ataaaatttc   2297

 attctggaaa aaaaaaaaa                                                2316




      <210> 465
      <211> 722
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (39)..(293)

      <400> 465
 acgggtctca cagtgacgtg acagtaaaca ctacacac    atg gca gcc cac agg      53
                                              Met Ala Ala His Arg
                                                1               5

 aca cac atg agc cag ccg atc aca gtg aca agc ccc tca gac cca aca      101
 Thr His Met Ser Gln Pro Ile Thr Val Thr Ser Pro Ser Asp Pro Thr
                  10                  15                  20

 cac gaa tac tca cac act cac att cat ata cac act cat aca cac aca      149
 His Glu Tyr Ser His Thr His Ile His Ile His Thr His Thr His Thr
              25                  30                  35

 ctc tcg cac tcc ctc tca tac ttt tac act cat tct aac aca cac aca      197
 Leu Ser His Ser Leu Ser Tyr Phe Tyr Thr His Ser Asn Thr His Thr
          40                  45                  50

 tgc tgt ccc aga gct aag gcc ctg aca cct gcc cca gtg aca ctc ccc      245
 Cys Cys Pro Arg Ala Lys Ala Leu Thr Pro Ala Pro Val Thr Leu Pro
      55                  60                  65

 cac cac cag cct ggg tcc ctg gct gct ggg cac cct cac tgt gtc tag      293
 His His Gln Pro Gly Ser Leu Ala Ala Gly His Pro His Cys Val 
  70                  75                  80

 agctggaagc tcccttcccc tctcccgctc ccacatgccc atagctgtcc actgcctgca    353

 gatcagggca gacccgtctg cttgcatcag aggcccacct ctctggaaga ttccggcatg    413

 tcccaccatg tcacatgtgg cccacctctc tggaagattc cggcatgtcc caccatgtca    473

 catgtggttc tctttgcctg tctcctctct gcacctttgc tcaagctgtt cctccccctg    533

 gcacaccgtt cctggctgcc cccaccatgt ctcaaaacaa atgcctggcc tcccatgaac    593

 ctgctccccc atgctgtcct ctgcctcggg gacagcacca gtgtcctacc cactgcacat    653

 gccagggccc aaggagcctc cccagcccct ccttcgcctc cttcaccctc acaccatgcc    713

 ctgtcccct                                                            722




      <210> 466
      <211> 516
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(516)

      <400> 466
  atg tta agc aag aaa cag gag ttc ctg gag aag aaa atc gag cag agg      48
  Met Leu Ser Lys Lys Gln Glu Phe Leu Glu Lys Lys Ile Glu Gln Arg
    1               5                  10                  15

 cac ggc acc aaa aac aag ccc gcg gcc ctc cag gca ctg aag cgt aag       96
 His Gly Thr Lys Asn Lys Pro Ala Ala Leu Gln Ala Leu Lys Arg Lys
              20                  25                  30

 aag agg tat gag aag cag ctg gcg cag atc gac ggc aca tta tca acc      144
 Lys Arg Tyr Glu Lys Gln Leu Ala Gln Ile Asp Gly Thr Leu Ser Thr
          35                  40                  45

 atc gag ttc cag cgg gag gcc ctg gag aat gcc aac acc aac acc gag      192
 Ile Glu Phe Gln Arg Glu Ala Leu Glu Asn Ala Asn Thr Asn Thr Glu
      50                  55                  60

 gtg ctc aag aac atg ggc tat gcc gcc aag gcc atg aag gcg gcc cat      240
 Val Leu Lys Asn Met Gly Tyr Ala Ala Lys Ala Met Lys Ala Ala His
  65                  70                  75                  80

 gac aac atg gac atc gat aaa gtt gat gag tta atg cag gac att gct      288
 Asp Asn Met Asp Ile Asp Lys Val Asp Glu Leu Met Gln Asp Ile Ala
                  85                  90                  95

 gac cag caa gaa ctt gca gag gag att tca aca gca att tcg aaa cct      336
 Asp Gln Gln Glu Leu Ala Glu Glu Ile Ser Thr Ala Ile Ser Lys Pro
             100                 105                 110

 gta ggg ttt gga gaa gag ttt gac gag gat gag ctc atg gcg gaa tta      384
 Val Gly Phe Gly Glu Glu Phe Asp Glu Asp Glu Leu Met Ala Glu Leu
         115                 120                 125

 gaa gaa cta gaa cag gag gaa cta gac aag aat ttg ctg gaa atc agt      432
 Glu Glu Leu Glu Gln Glu Glu Leu Asp Lys Asn Leu Leu Glu Ile Ser
     130                 135                 140

 gga ccc gaa aca gtc cct cta cca aat gtt ccc tct ata gcc cta cca      480
 Gly Pro Glu Thr Val Pro Leu Pro Asn Val Pro Ser Ile Ala Leu Pro
 145                 150                 155                 160

 tca aaa cct gcc aag aag agg aag acg acg aca tga                      516
 Ser Lys Pro Ala Lys Lys Arg Lys Thr Thr Thr 
                 165                 170





      <210> 467
      <211> 1662
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (373)..(1662)

      <400> 467
 cgcggcccat ggagctcgag aacatcgtag cggacacggt gctcctcaag gcccgggaag     60

 gtagcggtgg aaatcgcaaa ggcaaaagca agaaatggcg gcagatgctc cagttccccc    120

 acatcagcca gccggagctg agccgttgca tcgccttcca ggatgggatg gccgagtatg    180

 aagcgacccc ggatgagaag cggaaggcat gtgggcggcg gctaatgcag aattttcttg    240

 agccacaggt tcctgacctc atccctgagg tccccccggc agctggtgac gaactgcacc    300

 cagcggctgg agcaggggcc ctgcaaagaa ctctcccagg aactcacccg ggtgacccac    360

 gggtacctga gc    atg gcc cct ttt gcc gac tac ctc aac agc atc tac     408
                  Met Ala Pro Phe Ala Asp Tyr Leu Asn Ser Ile Tyr
                    1               5                  10

 ttc aac cgt ttc ctg cag tgg aag tgg ctg gaa agg cag cca gtg acc      456
 Phe Asn Arg Phe Leu Gln Trp Lys Trp Leu Glu Arg Gln Pro Val Thr
          15                  20                  25

 aaa aat acc ttc agg cag tac cga gtc ctg ggc aaa ggt ggc ttt ggg      504
 Lys Asn Thr Phe Arg Gln Tyr Arg Val Leu Gly Lys Gly Gly Phe Gly
      30                  35                  40

 gag gtg tgc gcc tgc cag gtg cgg gcc aca ggc aag atg tac gcc ttc      552
 Glu Val Cys Ala Cys Gln Val Arg Ala Thr Gly Lys Met Tyr Ala Phe
  45                  50                  55                  60

 aag aag cta gaa aaa aag cgg atc aag aag cag aaa ggg gag gcc atg      600
 Lys Lys Leu Glu Lys Lys Arg Ile Lys Lys Gln Lys Gly Glu Ala Met
                  65                  70                  75

 gcg ctg aac gag aag cag atc ctg gag aga gtg aac acg cag gcc gtc      648
 Ala Leu Asn Glu Lys Gln Ile Leu Glu Arg Val Asn Thr Gln Ala Val
              80                  85                  90

 ttc tac gtc ccg aga tct gct tgc ggt ctg gag gac ctg cac cgg gag      696
 Phe Tyr Val Pro Arg Ser Ala Cys Gly Leu Glu Asp Leu His Arg Glu
          95                 100                 105

 cgc ata gtg tac agg gac ctg aag ctc agg aac atc ttg ctg gat gac      744
 Arg Ile Val Tyr Arg Asp Leu Lys Leu Arg Asn Ile Leu Leu Asp Asp
     110                 115                 120

 cac ggc cac atc ctc gtc tcc gac ctg gga ctg gct gtg cac gtg ccc      792
 His Gly His Ile Leu Val Ser Asp Leu Gly Leu Ala Val His Val Pro
 125                 130                 135                 140

 gag ggc cag acc atc aaa ggc cgt gtg ggc acc gtg agc tac atg gct      840
 Glu Gly Gln Thr Ile Lys Gly Arg Val Gly Thr Val Ser Tyr Met Ala
                 145                 150                 155

 cca gag gtg gtg aag aat gaa ccg tac act ttc agc tct gac tgt tgg      888
 Pro Glu Val Val Lys Asn Glu Pro Tyr Thr Phe Ser Ser Asp Cys Trp
             160                 165                 170

 gcg cta ggc tgc ctc ccg cag gag atg att gca ggc cag tcg ctc ttc      936
 Ala Leu Gly Cys Leu Pro Gln Glu Met Ile Ala Gly Gln Ser Leu Phe
         175                 180                 185

 cag cag agg aag aag aag atc aag cgg gag gag gtg gag cgg ctg gtg      984
 Gln Gln Arg Lys Lys Lys Ile Lys Arg Glu Glu Val Glu Arg Leu Val
     190                 195                 200

 aag gag gac ccc gag gag tat tcc gag cgc ttt tcc ccg cag gcc tgc     1032
 Lys Glu Asp Pro Glu Glu Tyr Ser Glu Arg Phe Ser Pro Gln Ala Cys
 205                 210                 215                 220

 tca cag ctc ctc tgc aag gac ccc gct gaa cgc ctg ggg tgt cgt ggg     1080
 Ser Gln Leu Leu Cys Lys Asp Pro Ala Glu Arg Leu Gly Cys Arg Gly
                 225                 230                 235

 ggc agt gcc cgc gaa gtg aag gag cac ccc ctg ttg aag aag ctg aac     1128
 Gly Ser Ala Arg Glu Val Lys Glu His Pro Leu Leu Lys Lys Leu Asn
             240                 245                 250

 ttc aag cgg gtg gga gcc ggc atg ctg gag ccg ccc ttc aag cct gac     1176
 Phe Lys Arg Val Gly Ala Gly Met Leu Glu Pro Pro Phe Lys Pro Asp
         255                 260                 265

 cct cgg gcc att tac tgc aag gat att ctg gac att aaa cag ttc tct     1224
 Pro Arg Ala Ile Tyr Cys Lys Asp Ile Leu Asp Ile Lys Gln Phe Ser
     270                 275                 280

 agg gtc aag ggt gtg gag ctg gag gct acc gac caa gac ttc tac cag     1272
 Arg Val Lys Gly Val Glu Leu Glu Ala Thr Asp Gln Asp Phe Tyr Gln
 285                 290                 295                 300

 aag ttt gcc aca ggc agc gtg ccc atc ccc tgg cag aac ggg atg gtg     1320
 Lys Phe Ala Thr Gly Ser Val Pro Ile Pro Trp Gln Asn Gly Met Val
                 305                 310                 315

 gag act gag tgc ttc cag gag ctg aat gtc ttt ggg ctg gat ggc tca     1368
 Glu Thr Glu Cys Phe Gln Glu Leu Asn Val Phe Gly Leu Asp Gly Ser
             320                 325                 330

 gtt ccc cca gac ctg gac tgg aag ggc cag cca cct gca agg gac tgc     1416
 Val Pro Pro Asp Leu Asp Trp Lys Gly Gln Pro Pro Ala Arg Asp Cys
         335                 340                 345

 tgc aga gac tct tca gtt gcc aaa gga ttg ctg tgg aaa ctg cgg gga     1464
 Cys Arg Asp Ser Ser Val Ala Lys Gly Leu Leu Trp Lys Leu Arg Gly
     350                 355                 360

 cag cga gga aga gct ccc tac ccg cct cta gcc ccc agc cag agg ccc     1512
 Gln Arg Gly Arg Ala Pro Tyr Pro Pro Leu Ala Pro Ser Gln Arg Pro
 365                 370                 375                 380

 cca cgg gca gtg ggc ggt agt agc tac tcc gag tgc ctt tta cag ttt     1560
 Pro Arg Ala Val Gly Gly Ser Ser Tyr Ser Glu Cys Leu Leu Gln Phe
                 385                 390                 395

 tgc aca gtg gac ttc ccc att gtc cac tca agt tgt ggc ctg ggg aac     1608
 Cys Thr Val Asp Phe Pro Ile Val His Ser Ser Cys Gly Leu Gly Asn
             400                 405                 410

 aca gac gga act gtc ccc agt gtc ctc tgc ccc ctc agc ccc tgg cct     1656
 Thr Asp Gly Thr Val Pro Ser Val Leu Cys Pro Leu Ser Pro Trp Pro
         415                 420                 425

 gcc tga                                                             1662
 Ala 






      <210> 468
      <211> 480
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(480)

      <400> 468
  atg gaa acg gga ccc agc gaa gaa cct agc ggc cga aaa gag tcc cag      48
  Met Glu Thr Gly Pro Ser Glu Glu Pro Ser Gly Arg Lys Glu Ser Gln
    1               5                  10                  15

 gaa atg tgc ccc ccg gga tta ctg gta ttt gct ggc tcc tcg gaa caa       96
 Glu Met Cys Pro Pro Gly Leu Leu Val Phe Ala Gly Ser Ser Glu Gln
              20                  25                  30

 gat gcc aac ttg gct aag cag ttc tgg atc tcg gcg tcg atg tat ccc      144
 Asp Ala Asn Leu Ala Lys Gln Phe Trp Ile Ser Ala Ser Met Tyr Pro
          35                  40                  45

 cct agc gaa tct cag ctg gtg ctg cgc aga gac agc agt cag cgt ctg      192
 Pro Ser Glu Ser Gln Leu Val Leu Arg Arg Asp Ser Ser Gln Arg Leu
      50                  55                  60

 ccg gtg gcg cgg ccc agg agg agc aga ggg tct gaa aac agc cac tcc      240
 Pro Val Ala Arg Pro Arg Arg Ser Arg Gly Ser Glu Asn Ser His Ser
  65                  70                  75                  80

 tcg cag tct ttt cac ctt gcg agt aac aaa aat aga gac atc ttt gcc      288
 Ser Gln Ser Phe His Leu Ala Ser Asn Lys Asn Arg Asp Ile Phe Ala
                  85                  90                  95

 gaa gcc cta aag ata cag gaa tct gag gag aaa gta aag tat ctc caa      336
 Glu Ala Leu Lys Ile Gln Glu Ser Glu Glu Lys Val Lys Tyr Leu Gln
             100                 105                 110

 aag aag gaa gtc aca gta gat gag cag agc att gca tgt tct cca aag      384
 Lys Lys Glu Val Thr Val Asp Glu Gln Ser Ile Ala Cys Ser Pro Lys
         115                 120                 125

 gaa gtg att cca gaa aaa ttt gat aga cgt tca aaa aca tta tgc caa      432
 Glu Val Ile Pro Glu Lys Phe Asp Arg Arg Ser Lys Thr Leu Cys Gln
     130                 135                 140

 ggt tta aca gca tgt aag aga aac cct gcc atg ggc att gga atg tag      480
 Gly Leu Thr Ala Cys Lys Arg Asn Pro Ala Met Gly Ile Gly Met 
 145                 150                 155





      <210> 469
      <211> 6538
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (10)..(1962)

      <400> 469
 cgcgcgcca    atg atg act aag gct gtg ccg gag gaa ccc cga aag cca      48
              Met Met Thr Lys Ala Val Pro Glu Glu Pro Arg Lys Pro
                1               5                  10

 gga agg ctg acc cag gcc ctg aac tca ccc ctc acc tgg gag cat gtt       96
 Gly Arg Leu Thr Gln Ala Leu Asn Ser Pro Leu Thr Trp Glu His Val
      15                  20                  25

 tgg att tgc gtc ccc ggc ggc act cct gac tgt ctg aca gac acc ttc      144
 Trp Ile Cys Val Pro Gly Gly Thr Pro Asp Cys Leu Thr Asp Thr Phe
  30                  35                  40                  45

 aga gtg aag agg cca cat ctc agg cgc tct gcc agc aac ggt cat gtc      192
 Arg Val Lys Arg Pro His Leu Arg Arg Ser Ala Ser Asn Gly His Val
                  50                  55                  60

 cct ggg act cct gtc tac aga gaa aaa gaa gat atg tat gac gag att      240
 Pro Gly Thr Pro Val Tyr Arg Glu Lys Glu Asp Met Tyr Asp Glu Ile
              65                  70                  75

 att gag tta aag aag tca ttg cac gtg cag aag agc gac gtg gac ctg      288
 Ile Glu Leu Lys Lys Ser Leu His Val Gln Lys Ser Asp Val Asp Leu
          80                  85                  90

 atg aga acg aag ctc cgg cgc ctg gag gag gaa aac agc agg aag gac      336
 Met Arg Thr Lys Leu Arg Arg Leu Glu Glu Glu Asn Ser Arg Lys Asp
      95                 100                 105

 cgg cag ata gag cag ctc ctg gat ccc agc cgc ggc acg gat ttt gtt      384
 Arg Gln Ile Glu Gln Leu Leu Asp Pro Ser Arg Gly Thr Asp Phe Val
 110                 115                 120                 125

 cgg act ctg gca gag aaa agg ccc gat gcc agt tgg gtc att aac ggg      432
 Arg Thr Leu Ala Glu Lys Arg Pro Asp Ala Ser Trp Val Ile Asn Gly
                 130                 135                 140

 ctg aag cag agg atc ctg aag ctg gaa cag cag tgc aag gag aag gac      480
 Leu Lys Gln Arg Ile Leu Lys Leu Glu Gln Gln Cys Lys Glu Lys Asp
             145                 150                 155

 ggc acc atc agc aaa ctc cag acc gat atg aag act acc aac ctg gaa      528
 Gly Thr Ile Ser Lys Leu Gln Thr Asp Met Lys Thr Thr Asn Leu Glu
         160                 165                 170

 gag atg cgg atc gcc atg gag aca tac tac gag gag gtg cat cgt ctc      576
 Glu Met Arg Ile Ala Met Glu Thr Tyr Tyr Glu Glu Val His Arg Leu
     175                 180                 185

 cag acc ctc ttg gca agt tct gaa acc acc gga aag aag tat gat ggc      624
 Gln Thr Leu Leu Ala Ser Ser Glu Thr Thr Gly Lys Lys Tyr Asp Gly
 190                 195                 200                 205

 cgc ttg caa gct gtg ttt tgt gtg ttg cct tca cgt tgt gga agc tcc      672
 Arg Leu Gln Ala Val Phe Cys Val Leu Pro Ser Arg Cys Gly Ser Ser
                 210                 215                 220

 tct gag aat gtg tgg ctg tca cgt ggg ccc ctg ggg gag aag aag acg      720
 Ser Glu Asn Val Trp Leu Ser Arg Gly Pro Leu Gly Glu Lys Lys Thr
             225                 230                 235

 ggc gcc aaa agg cag aag aag atg ggc agt gcc ctc ctg agc ttg tcc      768
 Gly Ala Lys Arg Gln Lys Lys Met Gly Ser Ala Leu Leu Ser Leu Ser
         240                 245                 250

 cgg agt gtc cag gag ctc acg gaa gag aac cag agc ctg aag gag gac      816
 Arg Ser Val Gln Glu Leu Thr Glu Glu Asn Gln Ser Leu Lys Glu Asp
     255                 260                 265

 ctg gac cgc gtg ctg agc acc tcc cca acc atc tcc aag aca cag ggt      864
 Leu Asp Arg Val Leu Ser Thr Ser Pro Thr Ile Ser Lys Thr Gln Gly
 270                 275                 280                 285

 tat gtg gag tgg agc aag ccc cgg ctg ctg agg cgc att gtg gag ctg      912
 Tyr Val Glu Trp Ser Lys Pro Arg Leu Leu Arg Arg Ile Val Glu Leu
                 290                 295                 300

 gag aag aaa cta agt gtg atg gag agc tca aaa tca cac gcc gca gag      960
 Glu Lys Lys Leu Ser Val Met Glu Ser Ser Lys Ser His Ala Ala Glu
             305                 310                 315

 cca gtc aga tca cac ccg cca gcc tgc ctt gca tcc agc tct gcg ctg     1008
 Pro Val Arg Ser His Pro Pro Ala Cys Leu Ala Ser Ser Ser Ala Leu
         320                 325                 330

 cac aga cag cca cga ggg gac cgc aac aag gac cac gag cgt ctc cga     1056
 His Arg Gln Pro Arg Gly Asp Arg Asn Lys Asp His Glu Arg Leu Arg
     335                 340                 345

 ggg gct gtg aga gac ctg aag gaa gag cgg acc gcg ctg cag gag cag     1104
 Gly Ala Val Arg Asp Leu Lys Glu Glu Arg Thr Ala Leu Gln Glu Gln
 350                 355                 360                 365

 ctg ctg cag aga gat ttg gag gtg aag cag ctc ctg cag gcg aag gcc     1152
 Leu Leu Gln Arg Asp Leu Glu Val Lys Gln Leu Leu Gln Ala Lys Ala
                 370                 375                 380

 gac ctg gag aag gag ctg gag tgc gcg agg gag ggc gag gag gag agg     1200
 Asp Leu Glu Lys Glu Leu Glu Cys Ala Arg Glu Gly Glu Glu Glu Arg
             385                 390                 395

 aga gag cga gag gag gtt ttg aga gag gag att cag aca ctt acc agc     1248
 Arg Glu Arg Glu Glu Val Leu Arg Glu Glu Ile Gln Thr Leu Thr Ser
         400                 405                 410

 aag ctc caa gaa ttg caa gaa atg aag aaa gaa gag aaa gag gat tgc     1296
 Lys Leu Gln Glu Leu Gln Glu Met Lys Lys Glu Glu Lys Glu Asp Cys
     415                 420                 425

 ccg gaa gtt cct cat aag gcc caa gag ctc cca gct ccc act ccc agc     1344
 Pro Glu Val Pro His Lys Ala Gln Glu Leu Pro Ala Pro Thr Pro Ser
 430                 435                 440                 445

 agc agg cac tgc gag caa gac tgg ccg ccg gat tcc agc gag gag ggg     1392
 Ser Arg His Cys Glu Gln Asp Trp Pro Pro Asp Ser Ser Glu Glu Gly
                 450                 455                 460

 ctc ccg cgg ccc cgc tcc ccc tgc tct gat ggg aga aga gac gcc gcg     1440
 Leu Pro Arg Pro Arg Ser Pro Cys Ser Asp Gly Arg Arg Asp Ala Ala
             465                 470                 475

 gcc aga gtc ctg cag gcc cag tgg aag gtg tac aag cac aag aaa aaa     1488
 Ala Arg Val Leu Gln Ala Gln Trp Lys Val Tyr Lys His Lys Lys Lys
         480                 485                 490

 aag gct gtt ctg gat gag gcg gct gtg gtg ctt cag gca gct ttc agg     1536
 Lys Ala Val Leu Asp Glu Ala Ala Val Val Leu Gln Ala Ala Phe Arg
     495                 500                 505

 gga cat ctc acg cgg aca aag ctc tta gca agc aaa gca cat ggc tca     1584
 Gly His Leu Thr Arg Thr Lys Leu Leu Ala Ser Lys Ala His Gly Ser
 510                 515                 520                 525

 gag cca ccc agc gtg cca ggc ctc cca gac cag agc tct cct gtg ccc     1632
 Glu Pro Pro Ser Val Pro Gly Leu Pro Asp Gln Ser Ser Pro Val Pro
                 530                 535                 540

 cgc gtt ccg agc ccc atc gcc cag gcc acg ggc agc cct gtg cag gag     1680
 Arg Val Pro Ser Pro Ile Ala Gln Ala Thr Gly Ser Pro Val Gln Glu
             545                 550                 555

 gag gcc atc gtc atc atc cag tcc gct ctg cgg gca cac ctg gcc cgg     1728
 Glu Ala Ile Val Ile Ile Gln Ser Ala Leu Arg Ala His Leu Ala Arg
         560                 565                 570

 gcc agg cac agt gct acc ggt aaa aga acc acc acc gca gct tct acc     1776
 Ala Arg His Ser Ala Thr Gly Lys Arg Thr Thr Thr Ala Ala Ser Thr
     575                 580                 585

 agg agg aga tcg gct tca gcc aca cac ggg gac gcc tcc tcc cca ccc     1824
 Arg Arg Arg Ser Ala Ser Ala Thr His Gly Asp Ala Ser Ser Pro Pro
 590                 595                 600                 605

 ttc ctc gca gct ctt cct gac ccc tct ccc tca ggg cca cag gcc ttg     1872
 Phe Leu Ala Ala Leu Pro Asp Pro Ser Pro Ser Gly Pro Gln Ala Leu
                 610                 615                 620

 gca cct cta cct ggg gat gac gtc aac tcc gat gat tcc gac gat att     1920
 Ala Pro Leu Pro Gly Asp Asp Val Asn Ser Asp Asp Ser Asp Asp Ile
             625                 630                 635

 gtc att gca ccg tct ctg ccc acg aag aac ttt cca gtt tag gtccccg     1969
 Val Ile Ala Pro Ser Leu Pro Thr Lys Asn Phe Pro Val 
         640                 645                 650

 tcactgtctc cacgccgtga tggcagcgct gccgaggaca taggaaccac gactggaaag   2029

 ataatttatc gtgttaggag aagaacgatg atacctactt aacacctcag catctgcgtc   2089

 gtgtctcttt gtgcttttgt ttgtggaagg agacccaaat gcctttactt tattctctgg   2149

 ggagggccag cggctcgcat ccccctcatc tccagctgca gctcggatgg tggattttca   2209

 gtgccaacag acacatctgc cgtgaactcg cagatgccag ggagccctgt agtgacacgt   2269

 tctctgacag caccttgccg cctgcccacg accttgaccg tgaggagctg ctatccgcaa   2329

 ccagcgccga caccatgccc cctcttcctg gtgacaccct caacaaccag gatttgctcg   2389

 atctcagccc agcaggccag gcagacacac cccgctgtgc cttaggaagg tgtgagaccg   2449

 gcttccccca tccccacagc aaaacacggc ctgtcccaag ccagtgagga gctaaagaca   2509

 cccaggtccc caaatgatct tactccatgc cccacccgct cacaccgtcc tttcccgtca   2569

 cccttgctat cccctggagc actgccctcc agagctgccc ttcccaggaa ggaatttggt   2629

 tggattctgt cactgtggag accaagattt tttaaaattc ccaattacaa aagcagcatc   2689

 acacttgctt ctgagaacag cagggtgatg tctgttccca agctggtggc gggagcctta   2749

 gcctgtgtgg ggccacccgg ggaagaggag gagaggaggg tgaggaggca ggctcgccgt   2809

 tccaagggac agcataggct cgtggtgggg cgtgttgcat ctggtgtctg ggacagtccc   2869

 cgtcacccca tgtgtgcggc ctctgcactc ccaagctcca tggctgggct gggctgggct   2929

 gggctgggct gggccgggcg tgcggagcct gtggagccag cagctgcaga ggcctaggag   2989

 ggagttcctg ggggaagcgc acagtgtcca gtgcccatct cttgcttgtg tgtgagatta   3049

 gcccttgctg gggcgtcaag aggaagagcc ttagacctgg gcgggccttc aggggcatct   3109

 agacccctgc acagcccagg cctggtgtct gcatttccac agcacccctg tggggactcc   3169

 tgccggggct ggccgctgtc tcaggagaga cccaatggtt agaaagcccc tttttacaca   3229

 gctgacagct tctcccaagg cttccgtcca cggggacagg cttaacccct gggcgccttt   3289

 tctgcagcat ggcggccttc tgagtcacct aagctgagcc tgggtcattc tctgtggcgg   3349

 tcagaaggcc gatggcccca acacagtggc ttgtgaaagg gagagaggag gctctgcatg   3409

 tccacctgct ctatgggagg aggacacagg tgtccccagc ccagcctgtt ctctcccagt   3469

 cactcaggga tggggccacc caaagtgcag gacccgcccc accctgcggt tcgaagcctg   3529

 gcccctgtct ccacttagct tctgtttctg cagtgggtgg aagcgagtca gcggggggcc   3589

 tggcttgtgt acgtgttttc cttatttggt ctgtgggttg ccaagtccat ttttttttcc   3649

 actgaactgg ctggtaactt gatggactgt gtaactgaca caggccctct ttagacccct   3709

 gccttcaccc cacccgcccg ggtccactcc ctggggcgct gtcccaagcc atccctgctt   3769

 gccagctcaa agcttcaggt cctaggagcc agtccacctc gaaagccctg agaaagtgag   3829

 acacctgcac attcgctggg ggagaccctc cgttctcttg tggcagctgc tcccacttgt   3889

 taaaccaagc tgtttctgcg ggacgtgctc actcttggga accagtggcc tagagctttg   3949

 ggttacaggc atggagaggg ctttcctgcc tcaggcttgg aggccaatgt tccatacata   4009

 aaccgccatg tcctctggtg cagctgggct gctcttttaa aagccagcat ccatcttgaa   4069

 gctcgctggg taaatggcaa tgcattctca agccagtgtc ttcagctgat gcccagtgtc   4129

 cagtgctggt caccagtccc ctttgctggg tacagcctgc ctggctgttc tgtggtcctg   4189

 gaacgctgca gtgtggtttt gttccatgga gacagtacca agcggagagg cctccttgcc   4249

 cacggcccca gggcctgggg gccaggggtt ctggccctgc ggggacttag gcaggagggg   4309

 aagagaagcc catggagcca tgggaggggt gagctgtggg cggggcctag tcatgggagg   4369

 ggtgagctgt gggcggggcg agctgtgggt ggggcctagc catgggagag gtgagctgtg   4429

 aatggggcta gctatgggtg gggtgagctg tggacagggc ctagccatgg gaaaggtgag   4489

 ctgtgggcgg ggcctagtca cgggagaggt gagctgtggg cggggcctag tcatgggagg   4549

 ggtgagctgt ggatggggcc tagccatggg aggggtgagc tgtgagtggg gctgagccat   4609

 gggagcagca agctggtgga gtgggctggg cggagctgtg ggggctgctg gcagggccta   4669

 ggaaagtaga caactcccgg gggagacgaa gtagagagtg agtccccaag aaagggactc   4729

 ctgccccagc gtcaagtgcc aaagcaggcc ccatctacca cttcagggtc gacgttggtg   4789

 gcaggtgttg ttcacggtgt actgattgtc actgcaacac ctccacatca ccttgaactt   4849

 caagaacagc agcaaagctg tatctgctat cagaggctgt taggtagtcc agctttaaaa   4909

 taacacactc tttctctatc ccatgccctt taaacaagca gccacaggag atgtcagtct   4969

 ccagggcctg gccccactgt gttgacagca gtcacgtctg ttgagctgac actgctgagg   5029

 ctgaagctgg ccccgtgcag gtggctggtg agccacaggt gcagtacccg gaggtgtgct   5089

 ctcccctaga ggcctgtccc caactcctcc cctagaggcc tattcccgct gctcacagac   5149

 ctcagcagag gcaccagctg gagggctcca gggacatcct tggaaataca ggaggctttc   5209

 ctggcacagg gcacagctct taggaggcct ttgtaggacg ctgtctcccc agcgtgtcct   5269

 gctcatccag gatggggaga aagaggagga ggccccaggc tcagaagcca gggacagact   5329

 gccgacgatt accaaactga atccaggcag tgccatgacc ctgggtgtcc cttggttcac   5389

 atcacccacc agacagctgc ggagagagtg cagggagggg ctgggaccaa acaggccaga   5449

 aaccagcaga aaagaggcag aagtgaggtg ggtgtgcctg gggcacgaag ccagcgccgg   5509

 ggggatttca gtggagcctt acagccaggc tccgtgcgga ctgtgatgcc agagaggcgt   5569

 gcagcctctg ggcaagtcgg gagagggctt gggtggtccc cacaaggcag aagaggtgga   5629

 agggccagag aagaccacca agaccaccgt tcccgcaggc ctggggtgag tgacctgact   5689

 gagactagcg ggcagagcca agcagggcta aactccaacc cagggcccgg tgttggacaa   5749

 agtagctttt tctttgctcg tttgtctgtg tattaagaag agactaaaat agccaaacga   5809

 cgctggtcgc atgcgctggc tgtggtctgt ctgctgaatg tctatttttg tctcctgacg   5869

 agacgtgagg accatgccct tgatccctcc gatggaccag aaaccccctt ccttgcaaaa   5929

 aaaaggcaat tgaattagga aaagatagcc caacctagct cagatccacc aagataagca   5989

 cagcaaagct tggctgcatt tttgaggaat aaaaacctgc agaaagcacc gataaccttc   6049

 aagatctgaa tgagattcta ttataacccg tctaaacgat tgcaaaattc ctcctttggt   6109

 tttggaagca gcgtttgctc tcccgtggct cggattctct gaggaccagg gagttgacac   6169

 acaaaccccg ccatgggtcc gagccagcta tttctcaagg ctcccacctc gccaagctcc   6229

 caagggcctg ctggcagtgc ctacgctgtg ccaactaccc tgtctggtac agaccacggc   6289

 tgggtaagca cccttaaaag caacagaaat gacgtctgga agctgaaatg tgaaactgtc   6349

 aagatggctt aggagaggaa ggagtggacc cgctggtctt tggcattttg tatttagaat   6409

 tattctaact ttatacataa tgtataggcc gatcttttgg aagggataag gttttcattc   6469

 ttgtgcaact cattattctc attattggcc ttttaaataa aaagttgttt tgcagtgtga   6529

 aaaaaaaaa                                                           6538




      <210> 470
      <211> 1008
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1008)

      <400> 470
  atg gtc aaa gag cag gag agt cat ctc ttg ctc aga ttt cag gta tct      48
  Met Val Lys Glu Gln Glu Ser His Leu Leu Leu Arg Phe Gln Val Ser
    1               5                  10                  15

 tat cca gaa acg cag ggc att ttc cct gtt ctg tcc tcc atg ccc ctc       96
 Tyr Pro Glu Thr Gln Gly Ile Phe Pro Val Leu Ser Ser Met Pro Leu
              20                  25                  30

 ttc ccc atg cac tgc gct cat gcc act aat aat gca gcg tca aca cag      144
 Phe Pro Met His Cys Ala His Ala Thr Asn Asn Ala Ala Ser Thr Gln
          35                  40                  45

 ttc cac agt acg ggg att tcc ttg aca gcg gaa gcc act gac tgc acc      192
 Phe His Ser Thr Gly Ile Ser Leu Thr Ala Glu Ala Thr Asp Cys Thr
      50                  55                  60

 cca acg tat act gat gtc atc agc gag acc ctg tgc agc atg aag aag      240
 Pro Thr Tyr Thr Asp Val Ile Ser Glu Thr Leu Cys Ser Met Lys Lys
  65                  70                  75                  80

 cgg aaa gac aac ctc aat cag ttg tac cag cat cat tgg act gaa tgg      288
 Arg Lys Asp Asn Leu Asn Gln Leu Tyr Gln His His Trp Thr Glu Trp
                  85                  90                  95

 aat tat ttt gac aag cat cta aag gag ctg caa gac aac ttc tcc agg      336
 Asn Tyr Phe Asp Lys His Leu Lys Glu Leu Gln Asp Asn Phe Ser Arg
             100                 105                 110

 gaa atg aag aat att gat cca aaa gca gca gat aca aaa aag gca aac      384
 Glu Met Lys Asn Ile Asp Pro Lys Ala Ala Asp Thr Lys Lys Ala Asn
         115                 120                 125

 cac atg ttc atc cca cct tca gcc gtc aat gag gaa tca cct gac aag      432
 His Met Phe Ile Pro Pro Ser Ala Val Asn Glu Glu Ser Pro Asp Lys
     130                 135                 140

 aaa act aag gga agt ctc caa aga gaa att gag ttt aag ggt tgt tcg      480
 Lys Thr Lys Gly Ser Leu Gln Arg Glu Ile Glu Phe Lys Gly Cys Ser
 145                 150                 155                 160

 aac aaa aac cat ggg aaa ggt aga agt gtg aac atg agg gga aag gag      528
 Asn Lys Asn His Gly Lys Gly Arg Ser Val Asn Met Arg Gly Lys Glu
                 165                 170                 175

 gag agg gaa aga gaa gag aaa cag aag ttg aac att tct ttc cac tca      576
 Glu Arg Glu Arg Glu Glu Lys Gln Lys Leu Asn Ile Ser Phe His Ser
             180                 185                 190

 ctt cca agc cct gag gag ctc cac aac cta gaa cca gga agc gcc tac      624
 Leu Pro Ser Pro Glu Glu Leu His Asn Leu Glu Pro Gly Ser Ala Tyr
         195                 200                 205

 aga atc cgt gat att tct gct acg agg acc ccg ctt aga cgt ccc tca      672
 Arg Ile Arg Asp Ile Ser Ala Thr Arg Thr Pro Leu Arg Arg Pro Ser
     210                 215                 220

 tct tgg gag cct tcc cta ata tac cag gag caa ggg gtg ata att gtt      720
 Ser Trp Glu Pro Ser Leu Ile Tyr Gln Glu Gln Gly Val Ile Ile Val
 225                 230                 235                 240

 gtg cct cat ggt gtc tgt gtg agg agt gga tgc atg aat ctg tgg gag      768
 Val Pro His Gly Val Cys Val Arg Ser Gly Cys Met Asn Leu Trp Glu
                 245                 250                 255

 gca ctt aga aca gtg cct gac aca tgt ttt tat cat tat ttt atg gtg      816
 Ala Leu Arg Thr Val Pro Asp Thr Cys Phe Tyr His Tyr Phe Met Val
             260                 265                 270

 tac tcc tat tta tta aaa aaa atg tta act gta aaa cag cct cag gta      864
 Tyr Ser Tyr Leu Leu Lys Lys Met Leu Thr Val Lys Gln Pro Gln Val
         275                 280                 285

 ggt cct tca gga ggt att cca gaa gaa ggc att gtt atc ata ggt gat      912
 Gly Pro Ser Gly Gly Ile Pro Glu Glu Gly Ile Val Ile Ile Gly Asp
     290                 295                 300

 gac tgc tgc atg cat gta att gcc gca gag acc ttc cag tgg gac aaa      960
 Asp Cys Cys Met His Val Ile Ala Ala Glu Thr Phe Gln Trp Asp Lys
 305                 310                 315                 320

 gat gtg gaa gtg gaa gac agt gat att aat gat cct gac cct gtg tag     1008
 Asp Val Glu Val Glu Asp Ser Asp Ile Asn Asp Pro Asp Pro Val 
                 325                 330                 335





      <210> 471
      <211> 2247
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (436)..(822)

      <400> 471
 accggatact ttttaataca tctagtctaa aacttacagg aaggcatcct agcaccttct     60

 tttattattg tacagcagtg acagtgacga cagtgatgat ggcatctctc tatttttatg    120

 gaaacatctc caggaaatcc caagctgcac agtggagaat tacaggaaca gaagaagtgg    180

 tgtgaagtct gtcggtctct tccctggttc aatgaggagc tgaactgaat catactagag    240

 gcatgagtgt ctgcgctatt tttaaagagc tctggggaag tgtggttgtc ccaccttagg    300

 ctcctaatat aacactcatt tctatttgtg ggatggttaa caccatcttc catttggtct    360

 ttcctccact aatatattat ccttcactga agtcttattt ctacagttta attcttttta    420

 agctccagat gtgtt atg tat gcc ctc aaa gac cct atc atg ggt cag ggg     471
                  Met Tyr Ala Leu Lys Asp Pro Ile Met Gly Gln Gly
                    1               5                  10

 gca agg tct ggg ccc ctc atg cgt tcc tct ctt tcc cca ggc caa gta      519
 Ala Arg Ser Gly Pro Leu Met Arg Ser Ser Leu Ser Pro Gly Gln Val
          15                  20                  25

 aac acc ttg gca gga atc cag aaa acg atc cac gca gaa cat tgc aat      567
 Asn Thr Leu Ala Gly Ile Gln Lys Thr Ile His Ala Glu His Cys Asn
      30                  35                  40

 gtc aca gaa atg gcc gcc cac tgg cca cga agc cct ggc ccc acc ctg      615
 Val Thr Glu Met Ala Ala His Trp Pro Arg Ser Pro Gly Pro Thr Leu
  45                  50                  55                  60

 cga ggt cac ttc cta ccc tac caa cag cag cac ccc acc tca ctc ccc      663
 Arg Gly His Phe Leu Pro Tyr Gln Gln Gln His Pro Thr Ser Leu Pro
                  65                  70                  75

 tac gtg ctg gcc ttt cct gga gca cca aac cca ggg ctg gct gac cgc      711
 Tyr Val Leu Ala Phe Pro Gly Ala Pro Asn Pro Gly Leu Ala Asp Arg
              80                  85                  90

 aga gcc tta cct cca ggc agc ccc ttc ccc tgc acg cct cct gcc cca      759
 Arg Ala Leu Pro Pro Gly Ser Pro Phe Pro Cys Thr Pro Pro Ala Pro
          95                 100                 105

 ccg ctg gga cag aca ccc acc ctc cca cat gtt ggc tgg gcc tgc ttg      807
 Pro Leu Gly Gln Thr Pro Thr Leu Pro His Val Gly Trp Ala Cys Leu
     110                 115                 120

 gct act gca cag tga acttgtcgca tttccttcct gtctctgtcc tcctcagcag      862
 Ala Thr Ala Gln 
 125

 agacgggtgt ggtgatgaga tgacagtctt aggggtgtct tactctttat ttatggctct    922

 gtgacacttt taaagtgctg aatgttccta aaggctggta aattctttcc aagatcctcc    982

 agagaccggg cggcggtggt ggcaggaaga cgggtggggg caggagttgg aatctactta   1042

 gactataatt gcctcaagtt tgtgaactgt tagtataaaa atactcttgg agattttaat   1102

 ggttgaatga agattcacac tcattaaaca ccatggttga gggggaaaat tcagcctgtg   1162

 ttacaagaat gacttcacag cttgaagtac agaagcaaaa caataagagc tatcatcata   1222

 ctgattacat tatatatttt gaattttatt ttccttggag gtgggttggc tactctactg   1282

 tatagtacaa caagtagaac gaaagggaaa aaagctaccc tacagaaata cccagttttt   1342

 ggcgtcacct gctggcttta tcttccttta aaagctcttt cctaagcccc gatgatgggt   1402

 tcactacctt tggggacttc ctgtgcagct ctgaaccctg ttgcagcact tatcactgtc   1462

 ttggtggtat ccattctctg gtcttcttcc tctacagagt gagccctggg tcaacgcctt   1522

 gttcatccac agtgtctcag caggtagtgt gtgcctggca caaagttggc attccccatt   1582

 tagaagctgg tggagaagcc ctaagaacga agggacccca acggcctgac ctgcttcaac   1642

 agcatccagc acagacacgt attctcccaa acacttcctg atgacttcag tggtgctgga   1702

 gttttgctaa aggttttcat attttgcaac aattattcaa aaattactac tctaagaggg   1762

 tgtgatctgt cactgagaaa agagcctcct ggttactctg agctgcctgt ttatagccat   1822

 gtatttatgt acaacatttg catgacaata aaatgaggaa acggtcccta tgatctgtag   1882

 gtggagagat gaacgtggag ggcaggtgtg acccaggcgc ggctacctga taccggccca   1942

 aggccaggtg ccttggacgg cacgggcagg cgggcagcag cccgtgatga ctggacggac   2002

 tagggaatcc ctcgaatgca gactccacga gcccgtccag ctggagtggc atctcatctc   2062

 tgtatgaaag agcaagcctt catccactac aattagttct cggcacgcat tttagaatgt   2122

 agagtttcat gatctcgtca gaaagaaatt tacctaaata tgttctgatc aaagatgact   2182

 gacaggattt tataaattat cagcagagga gtaagagcaa ttataaacct tttaggggtc   2242

 tttcc                                                               2247




      <210> 472
      <211> 1522
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1326)

      <400> 472
  atg gag gcg ccg gcg gcc gag ccc ccg gtc cgg ggc tgc ggt ccc cag      48
  Met Glu Ala Pro Ala Ala Glu Pro Pro Val Arg Gly Cys Gly Pro Gln
    1               5                  10                  15

 ccc gcg cct gca ccc gcg cct gcc ccg gag agg aaa aag agc cac cgc       96
 Pro Ala Pro Ala Pro Ala Pro Ala Pro Glu Arg Lys Lys Ser His Arg
              20                  25                  30

 gcg ccg tcg ccg gcc cgg ccc aaa gac gtg gcc ggc tgg tcg ctg gct      144
 Ala Pro Ser Pro Ala Arg Pro Lys Asp Val Ala Gly Trp Ser Leu Ala
          35                  40                  45

 aag ggc cgc cgc ggc cca ggc ccg ggc tca gca gtc gcc tgc agc gcc      192
 Lys Gly Arg Arg Gly Pro Gly Pro Gly Ser Ala Val Ala Cys Ser Ala
      50                  55                  60

 gcg ttc tcc tca cgg ccg gac aag aag ggg cgc gca gtg gct ccc ggg      240
 Ala Phe Ser Ser Arg Pro Asp Lys Lys Gly Arg Ala Val Ala Pro Gly
  65                  70                  75                  80

 gcg cgc ggt gcg ggt gtg cgg gtg gcc ggg gtc cgc acc ggg gtc cgt      288
 Ala Arg Gly Ala Gly Val Arg Val Ala Gly Val Arg Thr Gly Val Arg
                  85                  90                  95

 gcc aag ggc cgt ccg cgc tcg ggt gcg ggg ccg cga ccg cca ccg ccg      336
 Ala Lys Gly Arg Pro Arg Ser Gly Ala Gly Pro Arg Pro Pro Pro Pro
             100                 105                 110

 ccc ccc agc ctc acg gat agc agc tcg gag gtg tcg gac tgc gcg tcg      384
 Pro Pro Ser Leu Thr Asp Ser Ser Ser Glu Val Ser Asp Cys Ala Ser
         115                 120                 125

 gag gag gcg cgc ctg ctg ggc ctg gag ctg gcg ctg agc agc gac gcc      432
 Glu Glu Ala Arg Leu Leu Gly Leu Glu Leu Ala Leu Ser Ser Asp Ala
     130                 135                 140

 gag tcc gcg gcc ggg ggc ccg gcg ggg gtc cgt acg ggg cag ccg gcc      480
 Glu Ser Ala Ala Gly Gly Pro Ala Gly Val Arg Thr Gly Gln Pro Ala
 145                 150                 155                 160

 cag ccc gcg ccc tcc gcg cag cag ccc ccg cgg ccg ccc gcc tcc ccg      528
 Gln Pro Ala Pro Ser Ala Gln Gln Pro Pro Arg Pro Pro Ala Ser Pro
                 165                 170                 175

 gac gag ccg tcg gtg gcc gcg tcg tcg gtg ggc agc agc cgc ttg ccg      576
 Asp Glu Pro Ser Val Ala Ala Ser Ser Val Gly Ser Ser Arg Leu Pro
             180                 185                 190

 ctc agc gcc tcg ctt gcc ttc tcc gac ctc acc gag gag atg ctg gac      624
 Leu Ser Ala Ser Leu Ala Phe Ser Asp Leu Thr Glu Glu Met Leu Asp
         195                 200                 205

 tgc ggg ccc agc ggc ttg gtg cgg gag ctg gag gag ctg cgc tcg gag      672
 Cys Gly Pro Ser Gly Leu Val Arg Glu Leu Glu Glu Leu Arg Ser Glu
     210                 215                 220

 aac gac tat ctc aag gac gag att gag gag ctg cgg gcc gag atg ctg      720
 Asn Asp Tyr Leu Lys Asp Glu Ile Glu Glu Leu Arg Ala Glu Met Leu
 225                 230                 235                 240

 gag atg cgg gac gtc tat atg gag gag gac gtg tat cag ctg cag gag      768
 Glu Met Arg Asp Val Tyr Met Glu Glu Asp Val Tyr Gln Leu Gln Glu
                 245                 250                 255

 ctg cga cag cag ctg gac cag gcc agc aag acc tgc cgc atc ctg cag      816
 Leu Arg Gln Gln Leu Asp Gln Ala Ser Lys Thr Cys Arg Ile Leu Gln
             260                 265                 270

 tac cgg ctg cgc aaa gcc gag cgc cgc agt ctc cgt gcc gcc cag acc      864
 Tyr Arg Leu Arg Lys Ala Glu Arg Arg Ser Leu Arg Ala Ala Gln Thr
         275                 280                 285

 ggc cag gtg gac ggc gag ctt atc cgt ggt ctg gag cag gat gtc aag      912
 Gly Gln Val Asp Gly Glu Leu Ile Arg Gly Leu Glu Gln Asp Val Lys
     290                 295                 300

 gtc tct aag gac atc tcc atg cgg ctg cat aag gag ctc gag gtg gtg      960
 Val Ser Lys Asp Ile Ser Met Arg Leu His Lys Glu Leu Glu Val Val
 305                 310                 315                 320

 gag aag aaa cgg gcg cgg ctg gag gag gag aac gaa gag ctt cgt cag     1008
 Glu Lys Lys Arg Ala Arg Leu Glu Glu Glu Asn Glu Glu Leu Arg Gln
                 325                 330                 335

 cgg ctc atc gag act gag ctg gct aag cag gtg ctg cag acg gag ctg     1056
 Arg Leu Ile Glu Thr Glu Leu Ala Lys Gln Val Leu Gln Thr Glu Leu
             340                 345                 350

 gag cga ccg aga gag gtg agg acc tca tgc atc cag cag ggc cag cct     1104
 Glu Arg Pro Arg Glu Val Arg Thr Ser Cys Ile Gln Gln Gly Gln Pro
         355                 360                 365

 agg gca ggt ggg cac atg caa gcc ccc cca agc cag tgt ctc tgt gag     1152
 Arg Ala Gly Gly His Met Gln Ala Pro Pro Ser Gln Cys Leu Cys Glu
     370                 375                 380

 ccc ccg ctt gtg gga aat ggg cag ctt atg cct ccc tgg caa ggt tgt     1200
 Pro Pro Leu Val Gly Asn Gly Gln Leu Met Pro Pro Trp Gln Gly Cys
 385                 390                 395                 400

 tta ttc att cat tcc tcc aac atg cat ttc ctg agc acc tac tgt gta     1248
 Leu Phe Ile His Ser Ser Asn Met His Phe Leu Ser Thr Tyr Cys Val
                 405                 410                 415

 aat tgt gtg ctg gac act aag gtt aca atg gtg aac aaa aca cac cca     1296
 Asn Cys Val Leu Asp Thr Lys Val Thr Met Val Asn Lys Thr His Pro
             420                 425                 430

 gtt cct gtc ctc agg gag ctc acg ggg taa t gagagagaga gtcattcatc     1347
 Val Pro Val Leu Arg Glu Leu Thr Gly 
         435                 440

 aaagaaccac agcgctgtgg gaggattaac ttgagaaaac atgcaacaat gtcaggcatg   1407

 gggctcagac ctctgtgcct cagtttctta cctatacaat ggggcagtgg tgccctgagt   1467

 cattgttggg gccaacagga taccgcatgt ggatgctgaa aaaattggga gaact        1522




      <210> 473
      <211> 2379
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (451)..(2331)

      <400> 473
 caaacatatt ttcaatgcca aaaaaggtct ggaatgaggt gggcactcag atgctttatt     60

 aaccactcta ggtattattc taacacttta tgtgcctatt aaattatccc gacatattag    120

 atttgctgaa ttgcagtcca tatttcgtag atatgatagc tgaagcacgg aatcattagg    180

 taacttgccc aaagtggcat tcacgactca taaatggctt aggatgtaaa ctcagtttta    240

 ttccctggga cgccctctct gctcttcagc acttgaagtt caggcagcga gagttgacat    300

 ggggccaggg ctgcgcccct ggggcgggtt gaagacaggg tgagtctctt gatattcagg    360

 aaatcatcgc gcacccagtc accagcgttc gggagcctgt cgcagcggga ccgacggaat    420

 ccggagcagg cgacagggcg cagaagcggg     atg tac ttc tgt tgg ggc gcc     471
                                      Met Tyr Phe Cys Trp Gly Ala
                                        1               5

 gac tcc agg gag ctg cag cgc cgg agg acg gcg ggc agc ccc ggg gct      519
 Asp Ser Arg Glu Leu Gln Arg Arg Arg Thr Ala Gly Ser Pro Gly Ala
          10                  15                  20

 gag cta ctg cag gcg gcc agc ggg gag cgc cac tct ctg ctg ctg ctg      567
 Glu Leu Leu Gln Ala Ala Ser Gly Glu Arg His Ser Leu Leu Leu Leu
      25                  30                  35

 acc aac cac agg gtc ctc tcg tgc gga gac aac agc agg ggt cag ctg      615
 Thr Asn His Arg Val Leu Ser Cys Gly Asp Asn Ser Arg Gly Gln Leu
  40                  45                  50                  55

 ggc cgc agg ggc gcg cag cgc ggg gag ctg cca gaa cca att cag gca      663
 Gly Arg Arg Gly Ala Gln Arg Gly Glu Leu Pro Glu Pro Ile Gln Ala
                  60                  65                  70

 ttg gaa acc cta att gtt gat ctc gtg agc tgc ggg aag gag cac tcc      711
 Leu Glu Thr Leu Ile Val Asp Leu Val Ser Cys Gly Lys Glu His Ser
              75                  80                  85

 ctg gct gtg tgc cac aaa gga agg gtc ttc gca tgg gga gct ggt tct      759
 Leu Ala Val Cys His Lys Gly Arg Val Phe Ala Trp Gly Ala Gly Ser
          90                  95                 100

 gaa ggg cag ctg ggg att gga gaa ttc aag gaa ata agt ttc aca cct      807
 Glu Gly Gln Leu Gly Ile Gly Glu Phe Lys Glu Ile Ser Phe Thr Pro
     105                 110                 115

 aag aaa ata atg act ctg aat gat ata aaa ata ata caa gtt tcc tgt      855
 Lys Lys Ile Met Thr Leu Asn Asp Ile Lys Ile Ile Gln Val Ser Cys
 120                 125                 130                 135

 gga cac tac cac tcc ctg gca tta tca aaa gat agc caa gtg ttt tcg      903
 Gly His Tyr His Ser Leu Ala Leu Ser Lys Asp Ser Gln Val Phe Ser
                 140                 145                 150

 tgg gga aag aac agc cat ggg cag ctg ggc ttg ggg aag gag ttc ccc      951
 Trp Gly Lys Asn Ser His Gly Gln Leu Gly Leu Gly Lys Glu Phe Pro
             155                 160                 165

 tcc caa gcc agc ccg cag agg gtg agg tcc ctg gag ggg atc cca ctg      999
 Ser Gln Ala Ser Pro Gln Arg Val Arg Ser Leu Glu Gly Ile Pro Leu
         170                 175                 180

 gct cag gtg gct gcc gga ggg gct cac agc ttt gcc ctg tct ctc tgt     1047
 Ala Gln Val Ala Ala Gly Gly Ala His Ser Phe Ala Leu Ser Leu Cys
     185                 190                 195

 ggg act tcg ttt ggc tgg gga agt aac agt gcc ggg cag ctg gcc ctc     1095
 Gly Thr Ser Phe Gly Trp Gly Ser Asn Ser Ala Gly Gln Leu Ala Leu
 200                 205                 210                 215

 agt ggg cgt aat gtc cca gtg caa agc aac aag cct ctc tca gtc ggt     1143
 Ser Gly Arg Asn Val Pro Val Gln Ser Asn Lys Pro Leu Ser Val Gly
                 220                 225                 230

 gca ctg aag aat cta ggt gtg gtt tat atc agc tgt ggt gat gca cac     1191
 Ala Leu Lys Asn Leu Gly Val Val Tyr Ile Ser Cys Gly Asp Ala His
             235                 240                 245

 act gcg gtg ctt acc cag gac ggg aaa gtg ttc aca ttt gga gac aat     1239
 Thr Ala Val Leu Thr Gln Asp Gly Lys Val Phe Thr Phe Gly Asp Asn
         250                 255                 260

 cgc tct gga cag ctg gga tac agc ccc act cct gag aag aga ggt cca     1287
 Arg Ser Gly Gln Leu Gly Tyr Ser Pro Thr Pro Glu Lys Arg Gly Pro
     265                 270                 275

 caa ctt gtg gaa aga att gat ggc cta gtt tcg cag ata gat tgt gga     1335
 Gln Leu Val Glu Arg Ile Asp Gly Leu Val Ser Gln Ile Asp Cys Gly
 280                 285                 290                 295

 agt tat cac acc ctg gca tat gtg cac acc act ggt cag gtg gta tct     1383
 Ser Tyr His Thr Leu Ala Tyr Val His Thr Thr Gly Gln Val Val Ser
                 300                 305                 310

 ttt ggt cat gga cca agt gac aca agc aag cca act cat ccg gag gcc     1431
 Phe Gly His Gly Pro Ser Asp Thr Ser Lys Pro Thr His Pro Glu Ala
             315                 320                 325

 ctg aca gag aac ttt gac att agc tgc ctg att tct gct gaa gac ttc     1479
 Leu Thr Glu Asn Phe Asp Ile Ser Cys Leu Ile Ser Ala Glu Asp Phe
         330                 335                 340

 gtg gat gtt caa gtc aaa cac att ttt gct gga aca tat gcc aac ttt     1527
 Val Asp Val Gln Val Lys His Ile Phe Ala Gly Thr Tyr Ala Asn Phe
     345                 350                 355

 gtg aca act cat cag gat act agt tcc aca cgt gct ccc ggg aaa acc     1575
 Val Thr Thr His Gln Asp Thr Ser Ser Thr Arg Ala Pro Gly Lys Thr
 360                 365                 370                 375

 ctg cca gaa ata agc cga att agc cag tcc atg gca gaa aaa tgg ata     1623
 Leu Pro Glu Ile Ser Arg Ile Ser Gln Ser Met Ala Glu Lys Trp Ile
                 380                 385                 390

 gca gtg aaa aga aga agt act gaa cat gaa atg gct aaa agt gaa att     1671
 Ala Val Lys Arg Arg Ser Thr Glu His Glu Met Ala Lys Ser Glu Ile
             395                 400                 405

 aga atg ata ttt tca tct cct gct tgt ctg act gca agt ttt tta aag     1719
 Arg Met Ile Phe Ser Ser Pro Ala Cys Leu Thr Ala Ser Phe Leu Lys
         410                 415                 420

 aaa aga gga act gga gaa acg act tcc att gat gtg gac tta gaa atg     1767
 Lys Arg Gly Thr Gly Glu Thr Thr Ser Ile Asp Val Asp Leu Glu Met
     425                 430                 435

 gca aga gat acc ttc aag aag tta aca aaa aag gaa tgg att tct tcc     1815
 Ala Arg Asp Thr Phe Lys Lys Leu Thr Lys Lys Glu Trp Ile Ser Ser
 440                 445                 450                 455

 atg ata act acg tgt ctc gag gat gat ctg ctc aga gct ctt cca tgc     1863
 Met Ile Thr Thr Cys Leu Glu Asp Asp Leu Leu Arg Ala Leu Pro Cys
                 460                 465                 470

 cat tct cca cac caa gaa gct tta tca gtt ttc ctc ctg ctc cca gaa     1911
 His Ser Pro His Gln Glu Ala Leu Ser Val Phe Leu Leu Leu Pro Glu
             475                 480                 485

 tgt cct gtg atg cat gat tct aag aac tgg aag aac ctg gtg gtt cca     1959
 Cys Pro Val Met His Asp Ser Lys Asn Trp Lys Asn Leu Val Val Pro
         490                 495                 500

 ttt gca aag gct gtg tgt gaa atg agt aaa caa tct ttg caa gtc cta     2007
 Phe Ala Lys Ala Val Cys Glu Met Ser Lys Gln Ser Leu Gln Val Leu
     505                 510                 515

 aag aag tgt tgg gca ttt ttg caa gaa tct tct ctg aat ccg ctg atc     2055
 Lys Lys Cys Trp Ala Phe Leu Gln Glu Ser Ser Leu Asn Pro Leu Ile
 520                 525                 530                 535

 cag atg ctt aaa gca gcc atc atc tct cag ctg ctt cat cag act aaa     2103
 Gln Met Leu Lys Ala Ala Ile Ile Ser Gln Leu Leu His Gln Thr Lys
                 540                 545                 550

 acc gaa cag gat cac tgt aat gtt aaa gct ctt tta gga atg atg aaa     2151
 Thr Glu Gln Asp His Cys Asn Val Lys Ala Leu Leu Gly Met Met Lys
             555                 560                 565

 gaa ctg cat aag gta aac aaa gct aac tgt cga cta cca gaa aat act     2199
 Glu Leu His Lys Val Asn Lys Ala Asn Cys Arg Leu Pro Glu Asn Thr
         570                 575                 580

 ttc aac ata aat gaa ctc tcc aac tta tta aac ttt tat att gat aga     2247
 Phe Asn Ile Asn Glu Leu Ser Asn Leu Leu Asn Phe Tyr Ile Asp Arg
     585                 590                 595

 ggg aga cag ctc ttt cgg gaa tac cac ctg ata cct gca gaa acc ccc     2295
 Gly Arg Gln Leu Phe Arg Glu Tyr His Leu Ile Pro Ala Glu Thr Pro
 600                 605                 610                 615

 cag cct gtt att tcc agg gat ttc cct ttt ctt taa atcg tttccaaaat     2345
 Gln Pro Val Ile Ser Arg Asp Phe Pro Phe Leu 
                 620                 625

 aaatttttgc agctggttcc cttttaagat cagt                               2379




      <210> 474
      <211> 1269
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (124)..(816)

      <400> 474
 gacggctcca ttcgagaggt gttgtatcgg gggaatgctg acgaagagtt gttccaagac     60

 caagatgacg atgaactctg gctcggtgac agtggtataa ctaattggga caacgtagac    120

 tat  atg tgg gac gag gag gaa gaa gaa gag gaa gat cag gac tat tac     168
      Met Trp Asp Glu Glu Glu Glu Glu Glu Glu Asp Gln Asp Tyr Tyr
        1               5                  10                  15

 cta gga ggc ttg aga cct gac ctg aga att gat gtc tac cga gaa gaa      216
 Leu Gly Gly Leu Arg Pro Asp Leu Arg Ile Asp Val Tyr Arg Glu Glu
                  20                  25                  30

 gaa ata ctg gaa gca tac gat gag gac gaa gat gaa gag ctg tat cct      264
 Glu Ile Leu Glu Ala Tyr Asp Glu Asp Glu Asp Glu Glu Leu Tyr Pro
              35                  40                  45

 gac atc cac ccg cct cct tcc ttg ccc ctt cca ggg cag ttc acc tgc      312
 Asp Ile His Pro Pro Pro Ser Leu Pro Leu Pro Gly Gln Phe Thr Cys
          50                  55                  60

 ccc cag tgc cga aag agc ttt aca cgt cgc agc ttt cgt ccc aac ttg      360
 Pro Gln Cys Arg Lys Ser Phe Thr Arg Arg Ser Phe Arg Pro Asn Leu
      65                  70                  75

 cag cta gcc aac atg gtc cag ata att cgc cag atg tgc ccc act cct      408
 Gln Leu Ala Asn Met Val Gln Ile Ile Arg Gln Met Cys Pro Thr Pro
  80                  85                  90                  95

 tat cgg gga aac cgg agt aat gat cag ggc atg tgc ttt aaa cac cag      456
 Tyr Arg Gly Asn Arg Ser Asn Asp Gln Gly Met Cys Phe Lys His Gln
                 100                 105                 110

 gaa gcc ctg aaa ctc ttc tgt gag gtg gac aaa gag gcc atc tgt gtg      504
 Glu Ala Leu Lys Leu Phe Cys Glu Val Asp Lys Glu Ala Ile Cys Val
             115                 120                 125

 gtg tgc cga gaa tcc agg agc cac aaa cag cac agc gtg ctg cct ttg      552
 Val Cys Arg Glu Ser Arg Ser His Lys Gln His Ser Val Leu Pro Leu
         130                 135                 140

 gag gag gtg gtg cag gag tac cag gcc aaa ctg cag ggg cac gtg gaa      600
 Glu Glu Val Val Gln Glu Tyr Gln Ala Lys Leu Gln Gly His Val Glu
     145                 150                 155

 cca ctg agg aag cac ctg gag gca gtg cag aag atg aaa gcc aca gga      648
 Pro Leu Arg Lys His Leu Glu Ala Val Gln Lys Met Lys Ala Thr Gly
 160                 165                 170                 175

 gga gag gcg agt gac aga act gaa gag cca gat gaa gtc aga gct ggc      696
 Gly Glu Ala Ser Asp Arg Thr Glu Glu Pro Asp Glu Val Arg Ala Gly
                 180                 185                 190

 agc ggt ggc ctc gga gtt ggg cga ctg aca cgg ttt ctg gct gaa gag      744
 Ser Gly Gly Leu Gly Val Gly Arg Leu Thr Arg Phe Leu Ala Glu Glu
             195                 200                 205

 cag gca ggg ctg gaa cgg cgt ctc aga gag atg cat gaa gcc cag ctg      792
 Gln Ala Gly Leu Glu Arg Arg Leu Arg Glu Met His Glu Ala Gln Leu
         210                 215                 220

 ggg cgt gcg gga gcc gcg gct tag tcgccttgca gaacaggccg ccagctcagc     846
 Gly Arg Ala Gly Ala Ala Ala 
     225                 230

 cgctgctggc agaaggccca ggagcggagc caagcagggg ggtctccggc tgctccagga    906

 catcaaagga gactttcaat aggtgtgaac gaggtacagt gcaagcccca gaggtctggt    966

 ccctgacccg tgcaacccca tagcatgact acctgacaga tgccaatcgt gaggaaacag   1026

 aagccggatg tactgtcaag gcttgcaaga gtggacctgg acgcttggac ctgacacggg   1086

 ctcacacggc ctgatgctgt cccctgacgg cccgggggtc gactgggcaa gcggggcaag   1146

 gaagaagatg accatccaag gctttccggc cgaagctgcg taaggggggc cgggtacagc   1206

 acgagcagca actggaagta aagggacgca gggagcggcg ggagcgcgga tcaccagaca   1266

 gaa                                                                 1269




      <210> 475
      <211> 3890
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (462)..(3836)

      <400> 475
 atttggccct cgaggccaag aattcggcac gagaaggaag tagcctacgt ccacgcctac     60

 aactgaagtc tcttgacaaa cacctcaccc ctgcctccgg gatgaaaggg ggtaacctag    120

 acctgaatgg gcttgaccat ctcacaactg ctcgcgtgac gaccgcattc gtggcaggta    180

 agaagattgc tgtatcaact caagaaagca gtaacttcac tgtctttgta ttttgaattg    240

 caacaacaac tttgatatca acaatgaagc aatgatatct aagaacaaaa gagtatttgc    300

 caacagtcat cataatatca agtgattgta taagcagaaa caagctgtca cagacctgtg    360

 cgtcagctaa tatatggaga atgctttctt ctgatactat ttacttagag gcagttttaa    420

 tataaatcat ttcaattata tctacatcaa ataaaataaa a    atg agt gaa gcc     473
                                                  Met Ser Glu Ala
                                                    1

 ccc aga ttc ttc gtt gga cca gaa gat aca gaa ata aat cct gga aat      521
 Pro Arg Phe Phe Val Gly Pro Glu Asp Thr Glu Ile Asn Pro Gly Asn
   5                  10                  15                  20

 tat cga cat ttc ttc cac cat gca gat gaa gac gat gag gag gaa gat      569
 Tyr Arg His Phe Phe His His Ala Asp Glu Asp Asp Glu Glu Glu Asp
                  25                  30                  35

 gat tct cca cca gaa agg cag att gtg gtt gga ata tgt tcc atg gca      617
 Asp Ser Pro Pro Glu Arg Gln Ile Val Val Gly Ile Cys Ser Met Ala
              40                  45                  50

 aag aaa tcc aaa tcc aaa cca atg aag gaa att ctt gaa cgg atc tcc      665
 Lys Lys Ser Lys Ser Lys Pro Met Lys Glu Ile Leu Glu Arg Ile Ser
          55                  60                  65

 tta ttt aaa tat atc aca gta gta gta ttt gaa gag gag gtt att ttg      713
 Leu Phe Lys Tyr Ile Thr Val Val Val Phe Glu Glu Glu Val Ile Leu
      70                  75                  80

 aat gaa cca gtg gaa aac tgg cct tta tgt gat tgt ctt att tct ttc      761
 Asn Glu Pro Val Glu Asn Trp Pro Leu Cys Asp Cys Leu Ile Ser Phe
  85                  90                  95                 100

 cat tct aaa gga ttt cca ctg gac aaa gcg gtt gcc tat gca aaa ctc      809
 His Ser Lys Gly Phe Pro Leu Asp Lys Ala Val Ala Tyr Ala Lys Leu
                 105                 110                 115

 agg aat cca ttt gta atc aat gac ttg aat atg cag tat ctc ata caa      857
 Arg Asn Pro Phe Val Ile Asn Asp Leu Asn Met Gln Tyr Leu Ile Gln
             120                 125                 130

 gat agg aga gaa gta tat agt att ctt caa gct gaa ggt att tta ctt      905
 Asp Arg Arg Glu Val Tyr Ser Ile Leu Gln Ala Glu Gly Ile Leu Leu
         135                 140                 145

 cct cgt tat gct att ttg aac cgt gac cca aat aat ccc aaa gaa tgt      953
 Pro Arg Tyr Ala Ile Leu Asn Arg Asp Pro Asn Asn Pro Lys Glu Cys
     150                 155                 160

 aat ctg att gaa ggg gaa gat cat gta gaa gta aat ggg gaa gtt ttt     1001
 Asn Leu Ile Glu Gly Glu Asp His Val Glu Val Asn Gly Glu Val Phe
 165                 170                 175                 180

 caa aag cca ttt gta gaa aag cca gtc agt gca gaa gat cac aat gtt     1049
 Gln Lys Pro Phe Val Glu Lys Pro Val Ser Ala Glu Asp His Asn Val
                 185                 190                 195

 tac att tat tac cca act tct gct ggt ggt gga agt caa aga ctc ttt     1097
 Tyr Ile Tyr Tyr Pro Thr Ser Ala Gly Gly Gly Ser Gln Arg Leu Phe
             200                 205                 210

 aga aag att ggc agt aga agt agt gtt tat tct cca gaa agc aat gta     1145
 Arg Lys Ile Gly Ser Arg Ser Ser Val Tyr Ser Pro Glu Ser Asn Val
         215                 220                 225

 cga aaa aca ggc tca tat ata tat gaa gag ttt atg ccc aca gat ggt     1193
 Arg Lys Thr Gly Ser Tyr Ile Tyr Glu Glu Phe Met Pro Thr Asp Gly
     230                 235                 240

 act gat gtt aag gtt tat aca gtg ggt cca gat tat gcc cat gct gaa     1241
 Thr Asp Val Lys Val Tyr Thr Val Gly Pro Asp Tyr Ala His Ala Glu
 245                 250                 255                 260

 gct cga aaa tct cca gca ctt gat ggc aag gtg gaa cga gac agt gaa     1289
 Ala Arg Lys Ser Pro Ala Leu Asp Gly Lys Val Glu Arg Asp Ser Glu
                 265                 270                 275

 gga aaa gaa gta aga tac cct gtt att ctc aat gca cga gag aaa tta     1337
 Gly Lys Glu Val Arg Tyr Pro Val Ile Leu Asn Ala Arg Glu Lys Leu
             280                 285                 290

 att gct tgg aaa gtc tgc ctt gct ttt aag caa aca gtt tgt ggc ttt     1385
 Ile Ala Trp Lys Val Cys Leu Ala Phe Lys Gln Thr Val Cys Gly Phe
         295                 300                 305

 gat ttg tta cgg gcc aat gga cag tcc tat gtc tgt gat gtc aat ggc     1433
 Asp Leu Leu Arg Ala Asn Gly Gln Ser Tyr Val Cys Asp Val Asn Gly
     310                 315                 320

 ttc agt ttt gtg aaa aat tcc atg aag tat tat gat gac tgt gca aaa     1481
 Phe Ser Phe Val Lys Asn Ser Met Lys Tyr Tyr Asp Asp Cys Ala Lys
 325                 330                 335                 340

 ata ctt gga aat att gta atg cga gaa ctt gct cca caa ttt cat att     1529
 Ile Leu Gly Asn Ile Val Met Arg Glu Leu Ala Pro Gln Phe His Ile
                 345                 350                 355

 cca tgg tca ata ccc tta gaa gct gaa gat atc cca att gta cca act     1577
 Pro Trp Ser Ile Pro Leu Glu Ala Glu Asp Ile Pro Ile Val Pro Thr
             360                 365                 370

 aca tct gga act atg atg gaa ctt aga tgt gtc ata gct gtt ata cgt     1625
 Thr Ser Gly Thr Met Met Glu Leu Arg Cys Val Ile Ala Val Ile Arg
         375                 380                 385

 cat ggg gat cga aca cca aaa aaa aaa atg aaa atg gaa gtg aga cat     1673
 His Gly Asp Arg Thr Pro Lys Lys Lys Met Lys Met Glu Val Arg His
     390                 395                 400

 cag aaa ttt ttt gat ctt ttt gaa aag tgt gat gga tat aaa tca ggg     1721
 Gln Lys Phe Phe Asp Leu Phe Glu Lys Cys Asp Gly Tyr Lys Ser Gly
 405                 410                 415                 420

 aaa tta aaa ctc aaa aaa cca aaa cag tta cag gaa gtg cta gat att     1769
 Lys Leu Lys Leu Lys Lys Pro Lys Gln Leu Gln Glu Val Leu Asp Ile
                 425                 430                 435

 gca cga cag ctt ctt atg gag cta ggg caa aat aat gat tct gaa att     1817
 Ala Arg Gln Leu Leu Met Glu Leu Gly Gln Asn Asn Asp Ser Glu Ile
             440                 445                 450

 gaa gaa aac aag cca aaa ctt gaa caa ctt aag act gta tta gag atg     1865
 Glu Glu Asn Lys Pro Lys Leu Glu Gln Leu Lys Thr Val Leu Glu Met
         455                 460                 465

 tat ggt cat ttt tct gga ata aat cgt aag gtt cag ttg acc tat ctc     1913
 Tyr Gly His Phe Ser Gly Ile Asn Arg Lys Val Gln Leu Thr Tyr Leu
     470                 475                 480

 cct cat ggt tgt cct aaa aca tct agt gaa gag gag gac agc cga aga     1961
 Pro His Gly Cys Pro Lys Thr Ser Ser Glu Glu Glu Asp Ser Arg Arg
 485                 490                 495                 500

 gaa gaa cca tct tta ctt ttg gtt cta aaa tgg gga ggt gaa tta act     2009
 Glu Glu Pro Ser Leu Leu Leu Val Leu Lys Trp Gly Gly Glu Leu Thr
                 505                 510                 515

 cct gca ggc agg gtc cag gct gaa gaa ctt gga aga gcc ttc agg tgt     2057
 Pro Ala Gly Arg Val Gln Ala Glu Glu Leu Gly Arg Ala Phe Arg Cys
             520                 525                 530

 atg tat cct gga ggt caa gga gat tat gca gga ttt cct ggt tgt ggt     2105
 Met Tyr Pro Gly Gly Gln Gly Asp Tyr Ala Gly Phe Pro Gly Cys Gly
         535                 540                 545

 tta ctt aga tta cat agc acc tac aga cat gac ctc aaa ata tat gcc     2153
 Leu Leu Arg Leu His Ser Thr Tyr Arg His Asp Leu Lys Ile Tyr Ala
     550                 555                 560

 tct gat gaa gga cga gtc cag atg act gca gct gct ttt gca aag ggg     2201
 Ser Asp Glu Gly Arg Val Gln Met Thr Ala Ala Ala Phe Ala Lys Gly
 565                 570                 575                 580

 ctt tta gct ttg gaa gga gag ctt aca ccc att ctt gtt caa atg gtg     2249
 Leu Leu Ala Leu Glu Gly Glu Leu Thr Pro Ile Leu Val Gln Met Val
                 585                 590                 595

 aaa agt gca aat atg aac ggt ctt ttg gat agt gat agt gac tct ctg     2297
 Lys Ser Ala Asn Met Asn Gly Leu Leu Asp Ser Asp Ser Asp Ser Leu
             600                 605                 610

 agc agt tgt cag caa cgt gtg aag gca agg ctt cat gaa ata ctt cag     2345
 Ser Ser Cys Gln Gln Arg Val Lys Ala Arg Leu His Glu Ile Leu Gln
         615                 620                 625

 aaa gac aga gat ttt act gct gaa gat tat gaa aag ctt act cca tct     2393
 Lys Asp Arg Asp Phe Thr Ala Glu Asp Tyr Glu Lys Leu Thr Pro Ser
     630                 635                 640

 gga agc att tct ctt atc aaa tca atg cat tta att aaa aac cct gtg     2441
 Gly Ser Ile Ser Leu Ile Lys Ser Met His Leu Ile Lys Asn Pro Val
 645                 650                 655                 660

 aag acc tgt gat aaa gtt tat tcc tta att cag agt ttg act tct caa     2489
 Lys Thr Cys Asp Lys Val Tyr Ser Leu Ile Gln Ser Leu Thr Ser Gln
                 665                 670                 675

 atc aga cat cga atg gaa gat cct aaa tca tca gat att cag ctt tac     2537
 Ile Arg His Arg Met Glu Asp Pro Lys Ser Ser Asp Ile Gln Leu Tyr
             680                 685                 690

 cat agt gaa aca ttg gag ctt atg cta cgt aga tgg tcc aag tta gag     2585
 His Ser Glu Thr Leu Glu Leu Met Leu Arg Arg Trp Ser Lys Leu Glu
         695                 700                 705

 aaa gac ttt aaa aca aag aat gga aga tat gat att agt aaa atc cct     2633
 Lys Asp Phe Lys Thr Lys Asn Gly Arg Tyr Asp Ile Ser Lys Ile Pro
     710                 715                 720

 gac ata tat gac tgt ata aaa tat gat gtc cag cat aat ggt tcc ttg     2681
 Asp Ile Tyr Asp Cys Ile Lys Tyr Asp Val Gln His Asn Gly Ser Leu
 725                 730                 735                 740

 aaa tta gaa aac aca atg gaa tta tat agg ctt tcg aag gca tta gca     2729
 Lys Leu Glu Asn Thr Met Glu Leu Tyr Arg Leu Ser Lys Ala Leu Ala
                 745                 750                 755

 gat att gtt atc cct cag gaa tat ggt ata act aaa gct gaa aaa ctg     2777
 Asp Ile Val Ile Pro Gln Glu Tyr Gly Ile Thr Lys Ala Glu Lys Leu
             760                 765                 770

 gag att gcc aaa ggc tac tgt act cct ctg gtt aga aaa att cgc tca     2825
 Glu Ile Ala Lys Gly Tyr Cys Thr Pro Leu Val Arg Lys Ile Arg Ser
         775                 780                 785

 gac ctt cag agg aca caa gat gat gac act gta aat aaa ctt cat cct     2873
 Asp Leu Gln Arg Thr Gln Asp Asp Asp Thr Val Asn Lys Leu His Pro
     790                 795                 800

 gtg tat tct aga ggt gtt ctg tct cct gaa cgt cat gtt cgt act aga     2921
 Val Tyr Ser Arg Gly Val Leu Ser Pro Glu Arg His Val Arg Thr Arg
 805                 810                 815                 820

 tta tat ttt acc agt gaa agt cat gta cat tct ttg ctg tct att ctt     2969
 Leu Tyr Phe Thr Ser Glu Ser His Val His Ser Leu Leu Ser Ile Leu
                 825                 830                 835

 cgc tat ggt gcc tta tgc aat gaa tca aag gat gaa cag tgg aaa cga     3017
 Arg Tyr Gly Ala Leu Cys Asn Glu Ser Lys Asp Glu Gln Trp Lys Arg
             840                 845                 850

 gct atg gat tat tta aac gtt gtc aat gag ctc aac tac atg act cag     3065
 Ala Met Asp Tyr Leu Asn Val Val Asn Glu Leu Asn Tyr Met Thr Gln
         855                 860                 865

 att gtt atc atg ctt tat gag gat cct aat aag gat ctt tcc tca gaa     3113
 Ile Val Ile Met Leu Tyr Glu Asp Pro Asn Lys Asp Leu Ser Ser Glu
     870                 875                 880

 gaa cgc ttt cat gtt gaa tta cac ttt agt ccg gga gcc aaa ggt tgt     3161
 Glu Arg Phe His Val Glu Leu His Phe Ser Pro Gly Ala Lys Gly Cys
 885                 890                 895                 900

 gaa gaa gac aaa aat ttg cca tct ggc tat gga tat aga cca gct tcc     3209
 Glu Glu Asp Lys Asn Leu Pro Ser Gly Tyr Gly Tyr Arg Pro Ala Ser
                 905                 910                 915

 aga gag aat gaa ggc agg aga cct ttt aaa att gat aat gat gat gaa     3257
 Arg Glu Asn Glu Gly Arg Arg Pro Phe Lys Ile Asp Asn Asp Asp Glu
             920                 925                 930

 cca cat act tct aaa aga gat gaa gtt gat cga gct gtg ata ttg ttt     3305
 Pro His Thr Ser Lys Arg Asp Glu Val Asp Arg Ala Val Ile Leu Phe
         935                 940                 945

 aaa cca atg gta tca gag cca att cat ata cac agg aag tct cca ctt     3353
 Lys Pro Met Val Ser Glu Pro Ile His Ile His Arg Lys Ser Pro Leu
     950                 955                 960

 cca aga tct agg aag acg gct aca aat gat gtt gta tct gaa aat gct     3401
 Pro Arg Ser Arg Lys Thr Ala Thr Asn Asp Val Val Ser Glu Asn Ala
 965                 970                 975                 980

 aat tac ctg aga aca cca aga act ctt gtg gaa cag aag cag aat cct     3449
 Asn Tyr Leu Arg Thr Pro Arg Thr Leu Val Glu Gln Lys Gln Asn Pro
                 985                 990                 995

 act gta ggc ttt gaa ttg tat tcc atg gtg cca tct att tgt cct cta     3497
 Thr Val Gly Phe Glu Leu Tyr Ser Met Val Pro Ser Ile Cys Pro Leu
            1000                1005                1010

 gaa act ctt cat aat gcc cta tct tta aag caa gtg gat gaa ttt ctt     3545
 Glu Thr Leu His Asn Ala Leu Ser Leu Lys Gln Val Asp Glu Phe Leu
        1015                1020                1025

 gct tcc att gct tct cca tca tct gac gtt cca cgg aag acc gct gaa     3593
 Ala Ser Ile Ala Ser Pro Ser Ser Asp Val Pro Arg Lys Thr Ala Glu
    1030                1035                1040

 att tcc tct aca gct tta cgt tcc agt cca ata atg aga aaa aaa gta     3641
 Ile Ser Ser Thr Ala Leu Arg Ser Ser Pro Ile Met Arg Lys Lys Val
1045                1050                1055                1060

 tct tta aat acg tat aca cct gca aag atc ctc cca aca cca cca gct     3689
 Ser Leu Asn Thr Tyr Thr Pro Ala Lys Ile Leu Pro Thr Pro Pro Ala
                1065                1070                1075

 acc tta aag agc act aaa gca agc agc aaa cca gct aca agt gga cct     3737
 Thr Leu Lys Ser Thr Lys Ala Ser Ser Lys Pro Ala Thr Ser Gly Pro
            1080                1085                1090

 tct agt gca gtt gtt cct aat acc tca tct cgg aaa aag aat ata act     3785
 Ser Ser Ala Val Val Pro Asn Thr Ser Ser Arg Lys Lys Asn Ile Thr
        1095                1100                1105

 agc aaa aca gaa acg cat gaa cac aaa aaa aac act ggg aaa aag aaa     3833
 Ser Lys Thr Glu Thr His Glu His Lys Lys Asn Thr Gly Lys Lys Lys
    1110                1115                1120

 tga aatc ttagcagaag ctggaacttt ttatacttat aaaaatagta tgttcttatg     3890
 






      <210> 476
      <211> 1964
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (70)..(1809)

      <400> 476
 cttatctttc tgaagcacag agaagcggtt atacgcagaa gtttgggaga actgggtaag     60

 gccgcacac    atg gaa att gcc agt ttc gtg ggt ccc aac gtc aat act     108
              Met Glu Ile Ala Ser Phe Val Gly Pro Asn Val Asn Thr
                1               5                  10

 gtg ggc aac ctt aga ccg gct caa agc gca gct ggg gac ggt gat gaa      156
 Val Gly Asn Leu Arg Pro Ala Gln Ser Ala Ala Gly Asp Gly Asp Glu
      15                  20                  25

 gtg cag agc gtc cac agc cag cga caa gac tgc caa gca act ggc agc      204
 Val Gln Ser Val His Ser Gln Arg Gln Asp Cys Gln Ala Thr Gly Ser
  30                  35                  40                  45

 ctg agt aac gga gaa aac aac gaa aaa aac gca ttc acc acc tac caa      252
 Leu Ser Asn Gly Glu Asn Asn Glu Lys Asn Ala Phe Thr Thr Tyr Gln
                  50                  55                  60

 caa gaa aca aaa aac acg acc acc cca cag tca gtc tac ttt tta ggc      300
 Gln Glu Thr Lys Asn Thr Thr Thr Pro Gln Ser Val Tyr Phe Leu Gly
              65                  70                  75

 gtg aat aag atg agc agc cag cac cgc gaa ggc tca cgg gga acg tcc      348
 Val Asn Lys Met Ser Ser Gln His Arg Glu Gly Ser Arg Gly Thr Ser
          80                  85                  90

 ccg ccc ctt ccg gtt ctt gcc tgc ttt gag ctg gct gtc gcg aga gtt      396
 Pro Pro Leu Pro Val Leu Ala Cys Phe Glu Leu Ala Val Ala Arg Val
      95                 100                 105

 ggt ccg cgg acg ccg gaa gta gtt cgt cgc tcc cta gcg gcc gaa ggg      444
 Gly Pro Arg Thr Pro Glu Val Val Arg Arg Ser Leu Ala Ala Glu Gly
 110                 115                 120                 125

 gcg ggc tcg cgg ggt ctc gac tgc ttt cgg ctt gct cgg cgg agc aag      492
 Ala Gly Ser Arg Gly Leu Asp Cys Phe Arg Leu Ala Arg Arg Ser Lys
                 130                 135                 140

 atg gcg gac atc tcc ctg gac gaa ctc atc agg aag cgc ggg gcg gcg      540
 Met Ala Asp Ile Ser Leu Asp Glu Leu Ile Arg Lys Arg Gly Ala Ala
             145                 150                 155

 gcg aaa gga cgg ctt aat gcc aga ccg gga gtt gga ggt gtc cga tct      588
 Ala Lys Gly Arg Leu Asn Ala Arg Pro Gly Val Gly Gly Val Arg Ser
         160                 165                 170

 cga gtt ggg atc cag caa ggc ctt ctc agc cag tca aca cgc aca gcc      636
 Arg Val Gly Ile Gln Gln Gly Leu Leu Ser Gln Ser Thr Arg Thr Ala
     175                 180                 185

 acc ttc cag cag aga ttt gat gcc cgg cag aag att ggc ctc tca gat      684
 Thr Phe Gln Gln Arg Phe Asp Ala Arg Gln Lys Ile Gly Leu Ser Asp
 190                 195                 200                 205

 gcc cgg ctc aaa ctg gga gtc aag gat gcc cgg gag aag ctt ttg cag      732
 Ala Arg Leu Lys Leu Gly Val Lys Asp Ala Arg Glu Lys Leu Leu Gln
                 210                 215                 220

 aaa gat gcc cga ttt cga atc aaa ggg aaa gtg cag gat gcc aga gag      780
 Lys Asp Ala Arg Phe Arg Ile Lys Gly Lys Val Gln Asp Ala Arg Glu
             225                 230                 235

 atg ttg aac tct cgc aag cag cag acc acg gtg ccc cag aag ccc cgc      828
 Met Leu Asn Ser Arg Lys Gln Gln Thr Thr Val Pro Gln Lys Pro Arg
         240                 245                 250

 cag gtt gct gat gcc cgg gag aag atc agc ttg aag agg agt tcc cct      876
 Gln Val Ala Asp Ala Arg Glu Lys Ile Ser Leu Lys Arg Ser Ser Pro
     255                 260                 265

 gct gcc ttc ata aac cca ccc att ggg aca gtg acc cct gct ctg aag      924
 Ala Ala Phe Ile Asn Pro Pro Ile Gly Thr Val Thr Pro Ala Leu Lys
 270                 275                 280                 285

 ctc acc aaa acc atc cag aga atg cat gtg gac cct gtg ggg tgg att      972
 Leu Thr Lys Thr Ile Gln Arg Met His Val Asp Pro Val Gly Trp Ile
                 290                 295                 300

 ctg acc act gag tgt ttc cag gtt cca cag cag aaa gcc atg gca cca     1020
 Leu Thr Thr Glu Cys Phe Gln Val Pro Gln Gln Lys Ala Met Ala Pro
             305                 310                 315

 ctt cat ccc cat cct gcc gga atg aga atc aat gtt gtc aat aac cac     1068
 Leu His Pro His Pro Ala Gly Met Arg Ile Asn Val Val Asn Asn His
         320                 325                 330

 cag gcc aaa cag aat tta tat gac ctg gat gaa gat gat gat ggt ata     1116
 Gln Ala Lys Gln Asn Leu Tyr Asp Leu Asp Glu Asp Asp Asp Gly Ile
     335                 340                 345

 gct tcc gtt cct act aaa cag atg aag ttt gca gcc tca ggc ggc ttt     1164
 Ala Ser Val Pro Thr Lys Gln Met Lys Phe Ala Ala Ser Gly Gly Phe
 350                 355                 360                 365

 ctc cac cac atg gct ggg cta agc agt tcc aag ctt tcc atg tcc aag     1212
 Leu His His Met Ala Gly Leu Ser Ser Ser Lys Leu Ser Met Ser Lys
                 370                 375                 380

 gcc ctc cct ctc acc aaa gtg gtt cag aat gat gca tac aca gct cct     1260
 Ala Leu Pro Leu Thr Lys Val Val Gln Asn Asp Ala Tyr Thr Ala Pro
             385                 390                 395

 gct ctc cct tcc tct att cga aca aaa gcc ttg acc aac atg tcc cgg     1308
 Ala Leu Pro Ser Ser Ile Arg Thr Lys Ala Leu Thr Asn Met Ser Arg
         400                 405                 410

 aca ctg gtg aac aag gaa gaa ccc ccc aaa gag ctg cca gct gct gag     1356
 Thr Leu Val Asn Lys Glu Glu Pro Pro Lys Glu Leu Pro Ala Ala Glu
     415                 420                 425

 cct gtt ctc agc cca ttg gaa ggc acc aag atg act gtg aat aat ctg     1404
 Pro Val Leu Ser Pro Leu Glu Gly Thr Lys Met Thr Val Asn Asn Leu
 430                 435                 440                 445

 cac cct cga gtc act gag gag gac att gtt gag ctt ttc tgt gtg tgt     1452
 His Pro Arg Val Thr Glu Glu Asp Ile Val Glu Leu Phe Cys Val Cys
                 450                 455                 460

 ggg gcc ctc aag cga gct cga ctg gtc cat cct ggg gta gcg gag gtg     1500
 Gly Ala Leu Lys Arg Ala Arg Leu Val His Pro Gly Val Ala Glu Val
             465                 470                 475

 gtg ttt gtg aaa aag gac gat gcc atc acc gca tat aag aag tac aac     1548
 Val Phe Val Lys Lys Asp Asp Ala Ile Thr Ala Tyr Lys Lys Tyr Asn
         480                 485                 490

 aac cgg tgt ctg gac ggg cag ccg atg aag tgc aac ctt cac atg aat     1596
 Asn Arg Cys Leu Asp Gly Gln Pro Met Lys Cys Asn Leu His Met Asn
     495                 500                 505

 ggg aat gtt atc acc tca gac cag ccc atc ctg ctg cgg ctg agt gac     1644
 Gly Asn Val Ile Thr Ser Asp Gln Pro Ile Leu Leu Arg Leu Ser Asp
 510                 515                 520                 525

 agc cca tca atg aaa aag gag agc gag ctg cct cgc agg gtg aac tct     1692
 Ser Pro Ser Met Lys Lys Glu Ser Glu Leu Pro Arg Arg Val Asn Ser
                 530                 535                 540

 gcc tcc tcc tcc aac ccc cct gct gaa gtg gac cct gac acc atc ctg     1740
 Ala Ser Ser Ser Asn Pro Pro Ala Glu Val Asp Pro Asp Thr Ile Leu
             545                 550                 555

 aag gca ctc ttc aag tcc tca ggg gcc tct gtg acc acg cag ccc aca     1788
 Lys Ala Leu Phe Lys Ser Ser Gly Ala Ser Val Thr Thr Gln Pro Thr
         560                 565                 570

 gaa ttc aaa atc aag ctt tga gc aggggagtga ggcagccaga agtgggggca     1841
 Glu Phe Lys Ile Lys Leu 
     575

 gaggagggtg gctctgtttc cccaaggcaa agcttatgac caatgggcca tcggactgga   1901

 gacccctgat tgtgggaagg gttgccaggg ataaagagct tcctcactgg aaaaaaaaaa   1961

 aaa                                                                 1964




      <210> 477
      <211> 711
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (118)..(354)

      <400> 477
 tttcgtattt ccactgttaa tcatccacct tcactatact gttgttctgt ctgctttggg     60

 cagggtgtag gagagagacc gtgtgccgtg gggctggtgg cctgctcagg gacagcc       117                                                                 
 atg ggg acc tgg cag ctc aaa aca gat ggc agc aga aca aaa gaa act      165
 Met Gly Thr Trp Gln Leu Lys Thr Asp Gly Ser Arg Thr Lys Glu Thr
   1               5                  10                  15

 ttt gct ttg gaa gca cag cca aac tcc cca ggg cat cgt cat aga tgg      213
 Phe Ala Leu Glu Ala Gln Pro Asn Ser Pro Gly His Arg His Arg Trp
              20                  25                  30

 cac cta gag cat ggg ctg cct cag tca ggg gga cgt gcc tgt gtt gtc      261
 His Leu Glu His Gly Leu Pro Gln Ser Gly Gly Arg Ala Cys Val Val
          35                  40                  45

 cag aga gcc cag cca ggg acg aaa aag gag atg agg ccc ctt tcc tcc      309
 Gln Arg Ala Gln Pro Gly Thr Lys Lys Glu Met Arg Pro Leu Ser Ser
      50                  55                  60

 atg tcc cca tgc cca gac aca tac ctt ggc cgt aat ttc ttt tag aat      357
 Met Ser Pro Cys Pro Asp Thr Tyr Leu Gly Arg Asn Phe Phe 
  65                  70                  75

 ccctttggga aggaaataca ggattgaggg attttggagt ttctggtaaa ctcaccctcc    417

 ctccagcccc gctatgagga ggaaagtaga gatgaaagac tcacgctgtt catggacttg    477

 gagaggatta tctttgagcc aagatttgga caggagtgaa gtcggtcctt aagaatttgt    537

 ggcgcgaccg gagctgggct cctgacaggt gggcttgtgt tgtgtcccct ctgatggcac    597

 caaagtccag ggaagggggc tcttgatgtc tgctggggga gtgggggcag ctcaggatgc    657

 aatgcagtgc cctgtcctgg ctactcacct gagggtgtag ctcgcaaagg tggg          711




      <210> 478
      <211> 4239
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4239)

      <400> 478
  atg aag caa gcg aag gag gaa gct ggg gga gat gag agc aga gaa gaa      48
  Met Lys Gln Ala Lys Glu Glu Ala Gly Gly Asp Glu Ser Arg Glu Glu
    1               5                  10                  15

 gct gga tgt tac ggg acg tgg tgc gga gta cga gag aga aac ctg aag       96
 Ala Gly Cys Tyr Gly Thr Trp Cys Gly Val Arg Glu Arg Asn Leu Lys
              20                  25                  30

 caa aaa gat gct tct cac gtt ctc act atg tct gct cca gac gaa ggg      144
 Gln Lys Asp Ala Ser His Val Leu Thr Met Ser Ala Pro Asp Glu Gly
          35                  40                  45

 aga cgg gat ccc ccc aaa ccg aag ggc aag acc ctg ggc agc ttc ttt      192
 Arg Arg Asp Pro Pro Lys Pro Lys Gly Lys Thr Leu Gly Ser Phe Phe
      50                  55                  60

 ggg tcc ctg cct ggc ttc agc tct gcc cgg aac ctg gtg gcc aac gca      240
 Gly Ser Leu Pro Gly Phe Ser Ser Ala Arg Asn Leu Val Ala Asn Ala
  65                  70                  75                  80

 cat agc tcg gcg aga gcc cgg ccg gcc gct gac ccc aca gga gcg cct      288
 His Ser Ser Ala Arg Ala Arg Pro Ala Ala Asp Pro Thr Gly Ala Pro
                  85                  90                  95

 gct gcc gag gct gcc caa cca cag gct cag gtg gct gcc cac cca gag      336
 Ala Ala Glu Ala Ala Gln Pro Gln Ala Gln Val Ala Ala His Pro Glu
             100                 105                 110

 cag acg gcc cca tgg acg gag aag gag ctg caa cct tcg gaa aag atg      384
 Gln Thr Ala Pro Trp Thr Glu Lys Glu Leu Gln Pro Ser Glu Lys Met
         115                 120                 125

 gtg tcc ggg gcc aaa gac ctg gtg tgt tcc aag atg tcc agg gcc aag      432
 Val Ser Gly Ala Lys Asp Leu Val Cys Ser Lys Met Ser Arg Ala Lys
     130                 135                 140

 gat gcc gtg tcc tcc ggg gtg gcc agc gtg gtg gac gtg gct aag gga      480
 Asp Ala Val Ser Ser Gly Val Ala Ser Val Val Asp Val Ala Lys Gly
 145                 150                 155                 160

 gtg gtc cag gga ggc ctg gac acc act cgg tct gca ctt acg ggc acc      528
 Val Val Gln Gly Gly Leu Asp Thr Thr Arg Ser Ala Leu Thr Gly Thr
                 165                 170                 175

 aag gag gtg gtg tcc agc ggg gtc aca ggg gcc atg gac atg gct aag      576
 Lys Glu Val Val Ser Ser Gly Val Thr Gly Ala Met Asp Met Ala Lys
             180                 185                 190

 ggg gcc gtc caa ggg ggt ctg gac acc tcg aag gct gtc ctc acc ggc      624
 Gly Ala Val Gln Gly Gly Leu Asp Thr Ser Lys Ala Val Leu Thr Gly
         195                 200                 205

 acc aag gac acg gtg tcc act ggg ctc acg ggg gca gtg aat gtg gcc      672
 Thr Lys Asp Thr Val Ser Thr Gly Leu Thr Gly Ala Val Asn Val Ala
     210                 215                 220

 aaa ggg acc gta cag gcc ggt gtg gac acc acc aag act gtg ctg acc      720
 Lys Gly Thr Val Gln Ala Gly Val Asp Thr Thr Lys Thr Val Leu Thr
 225                 230                 235                 240

 ggc acc aaa gac aca gtg act act ggg gtc atg ggg gca gtg aac ttg      768
 Gly Thr Lys Asp Thr Val Thr Thr Gly Val Met Gly Ala Val Asn Leu
                 245                 250                 255

 gcc aaa ggg act gtc cag act ggc gtg gaa acc tcc aag gct gtg ctg      816
 Ala Lys Gly Thr Val Gln Thr Gly Val Glu Thr Ser Lys Ala Val Leu
             260                 265                 270

 acc ggc acc aaa gat gct gtg tcc act ggg ctc aca ggg gca gtg aat      864
 Thr Gly Thr Lys Asp Ala Val Ser Thr Gly Leu Thr Gly Ala Val Asn
         275                 280                 285

 gtg gcc aga gga agc att cag acc ggt gtg gac acc agt aag act gtc      912
 Val Ala Arg Gly Ser Ile Gln Thr Gly Val Asp Thr Ser Lys Thr Val
     290                 295                 300

 cta aca ggt acc aag gac acc gtc tgt agt ggg gtg act ggt gcc atg      960
 Leu Thr Gly Thr Lys Asp Thr Val Cys Ser Gly Val Thr Gly Ala Met
 305                 310                 315                 320

 aat gtg gcc aaa gga acc atc cag acc ggc gtg gac acc agt aag act     1008
 Asn Val Ala Lys Gly Thr Ile Gln Thr Gly Val Asp Thr Ser Lys Thr
                 325                 330                 335

 gtc cta aca ggt acc aag gac acc gtc tgt agt ggg gtg act ggt gcc     1056
 Val Leu Thr Gly Thr Lys Asp Thr Val Cys Ser Gly Val Thr Gly Ala
             340                 345                 350

 atg aat gtg gcc aaa gga acc atc cag acc ggc gtg gac acc agt aag     1104
 Met Asn Val Ala Lys Gly Thr Ile Gln Thr Gly Val Asp Thr Ser Lys
         355                 360                 365

 act gtc cta aca ggt acc aag gac acc gtc tgt agt ggg gtg act ggt     1152
 Thr Val Leu Thr Gly Thr Lys Asp Thr Val Cys Ser Gly Val Thr Gly
     370                 375                 380

 gcc atg aat gtg gcc aaa gga acc atc cag acc ggc gtg gac acc acc     1200
 Ala Met Asn Val Ala Lys Gly Thr Ile Gln Thr Gly Val Asp Thr Thr
 385                 390                 395                 400

 aag act gtc cta act ggc acc aag aac act gtc tgc agt ggg gtg acc     1248
 Lys Thr Val Leu Thr Gly Thr Lys Asn Thr Val Cys Ser Gly Val Thr
                 405                 410                 415

 ggt gcc gtg aac ttg gcc aaa gag gcc atc cag ggg ggc ctg gat acc     1296
 Gly Ala Val Asn Leu Ala Lys Glu Ala Ile Gln Gly Gly Leu Asp Thr
             420                 425                 430

 acc aag tct atg gtc atg ggt acg aaa gac acg atg tcc act ggg ctc     1344
 Thr Lys Ser Met Val Met Gly Thr Lys Asp Thr Met Ser Thr Gly Leu
         435                 440                 445

 aca ggg gca gcg aat gtg gcc aag ggg gcc atg caa act ggg ctg aac     1392
 Thr Gly Ala Ala Asn Val Ala Lys Gly Ala Met Gln Thr Gly Leu Asn
     450                 455                 460

 aca acc caa aat atc gca aca ggt aca aag gac acc gtc tgc agt ggg     1440
 Thr Thr Gln Asn Ile Ala Thr Gly Thr Lys Asp Thr Val Cys Ser Gly
 465                 470                 475                 480

 gtg act ggt gcc atg aat ttg gcc aga gga acc atc cag aca ggc gtg     1488
 Val Thr Gly Ala Met Asn Leu Ala Arg Gly Thr Ile Gln Thr Gly Val
                 485                 490                 495

 gac acc acc aag atc gtt cta act ggt acc aag gac act gtc tgc agt     1536
 Asp Thr Thr Lys Ile Val Leu Thr Gly Thr Lys Asp Thr Val Cys Ser
             500                 505                 510

 ggg gtc acc ggt gct gcg aat gtg gcc aaa ggg gcc gtc cag ggc ggc     1584
 Gly Val Thr Gly Ala Ala Asn Val Ala Lys Gly Ala Val Gln Gly Gly
         515                 520                 525

 ctg gac act aca aag tct gtc ctg act ggc act aaa gat gct gtg tcc     1632
 Leu Asp Thr Thr Lys Ser Val Leu Thr Gly Thr Lys Asp Ala Val Ser
     530                 535                 540

 act ggg ctc aca ggg gct gtg aac gtg gcc aaa ggg acc gtc cag acc     1680
 Thr Gly Leu Thr Gly Ala Val Asn Val Ala Lys Gly Thr Val Gln Thr
 545                 550                 555                 560

 ggc gta gac acc acc aag act gtc cta acc ggc acc aag gac acc gtc     1728
 Gly Val Asp Thr Thr Lys Thr Val Leu Thr Gly Thr Lys Asp Thr Val
                 565                 570                 575

 tgc agt ggg gtg acc agt gct gtg aac gtg gcc aaa ggg gcc gtc cag     1776
 Cys Ser Gly Val Thr Ser Ala Val Asn Val Ala Lys Gly Ala Val Gln
             580                 585                 590

 ggg ggc ctg gac acc acc aag tct gtg gtc ata ggt aca aaa gac acg     1824
 Gly Gly Leu Asp Thr Thr Lys Ser Val Val Ile Gly Thr Lys Asp Thr
         595                 600                 605

 atg tcc act ggg ctc acg ggg gca gcg aat gtg gcc aag ggg gct gtc     1872
 Met Ser Thr Gly Leu Thr Gly Ala Ala Asn Val Ala Lys Gly Ala Val
     610                 615                 620

 cag aca ggt gta gac aca gcc aag acc gtg ctg acc ggc acc aag gac     1920
 Gln Thr Gly Val Asp Thr Ala Lys Thr Val Leu Thr Gly Thr Lys Asp
 625                 630                 635                 640

 aca gtg act act ggg ctc gtg ggg gca gtg aat gtc gcc aaa ggg acc     1968
 Thr Val Thr Thr Gly Leu Val Gly Ala Val Asn Val Ala Lys Gly Thr
                 645                 650                 655

 gtc cag aca ggc atg gac acc acc aaa act gtc cta acc ggt acc aag     2016
 Val Gln Thr Gly Met Asp Thr Thr Lys Thr Val Leu Thr Gly Thr Lys
             660                 665                 670

 gac acc atc tac agt ggg gtc acc agt gcc gtg aac gtg gcc aag ggg     2064
 Asp Thr Ile Tyr Ser Gly Val Thr Ser Ala Val Asn Val Ala Lys Gly
         675                 680                 685

 gct gtg caa act ggg ctg aaa acg acc caa aat atc gcg aca ggt aca     2112
 Ala Val Gln Thr Gly Leu Lys Thr Thr Gln Asn Ile Ala Thr Gly Thr
     690                 695                 700

 aag aac acc ttt ggc agt ggg gtg acc agt gct gtg aat gtg gcc aaa     2160
 Lys Asn Thr Phe Gly Ser Gly Val Thr Ser Ala Val Asn Val Ala Lys
 705                 710                 715                 720

 ggg gct gcc cag aca ggt gta gac acg gcc aag acc gtg ctg acc ggc     2208
 Gly Ala Ala Gln Thr Gly Val Asp Thr Ala Lys Thr Val Leu Thr Gly
                 725                 730                 735

 acc aag gac aca gtc act act ggg ctc atg ggg gca gtg aat gtc gcc     2256
 Thr Lys Asp Thr Val Thr Thr Gly Leu Met Gly Ala Val Asn Val Ala
             740                 745                 750

 aaa ggg act gtc cag acc agt gtg gac acc acc aag act gtc cta act     2304
 Lys Gly Thr Val Gln Thr Ser Val Asp Thr Thr Lys Thr Val Leu Thr
         755                 760                 765

 ggt acc aag gac acc gtc tgc agt ggg gtg acc ggt gct gcg aat gtg     2352
 Gly Thr Lys Asp Thr Val Cys Ser Gly Val Thr Gly Ala Ala Asn Val
     770                 775                 780

 gcc aaa ggg gcc atc caa ggg ggc ctg gac act aca aag tct gtc ctg     2400
 Ala Lys Gly Ala Ile Gln Gly Gly Leu Asp Thr Thr Lys Ser Val Leu
 785                 790                 795                 800

 act ggc act aaa gat gct gtg tcc act ggg ctc aca ggg gct gtg aag     2448
 Thr Gly Thr Lys Asp Ala Val Ser Thr Gly Leu Thr Gly Ala Val Lys
                 805                 810                 815

 ttg gcc aaa ggg act gtc cag acc ggc atg gac acc acc aag act gtg     2496
 Leu Ala Lys Gly Thr Val Gln Thr Gly Met Asp Thr Thr Lys Thr Val
             820                 825                 830

 tta act ggt acc aag gat gct gtg tgc agt ggg gtg acc ggt gct gcg     2544
 Leu Thr Gly Thr Lys Asp Ala Val Cys Ser Gly Val Thr Gly Ala Ala
         835                 840                 845

 aat gtg gcc aag ggg gcc gtc cag atg ggt gta gac acg gcc aag acc     2592
 Asn Val Ala Lys Gly Ala Val Gln Met Gly Val Asp Thr Ala Lys Thr
     850                 855                 860

 gtg ctg acc ggt acc aag gac act gtc tgc agt ggg gtc acc ggt gct     2640
 Val Leu Thr Gly Thr Lys Asp Thr Val Cys Ser Gly Val Thr Gly Ala
 865                 870                 875                 880

 gcg aac gtg gcc aag ggt gct gtg caa act ggg ctg aaa acg acc caa     2688
 Ala Asn Val Ala Lys Gly Ala Val Gln Thr Gly Leu Lys Thr Thr Gln
                 885                 890                 895

 aat atc gca aca ggt aca aag aac acc ctt ggc agt ggg gtg acc ggt     2736
 Asn Ile Ala Thr Gly Thr Lys Asn Thr Leu Gly Ser Gly Val Thr Gly
             900                 905                 910

 gct gcg aaa gtg gcc aaa ggg gcc gtc cag ggg ggc ctg gac act aca     2784
 Ala Ala Lys Val Ala Lys Gly Ala Val Gln Gly Gly Leu Asp Thr Thr
         915                 920                 925

 aag tct gtc ctg act ggc act aaa gat gcc gtg tcc act ggg ctc aca     2832
 Lys Ser Val Leu Thr Gly Thr Lys Asp Ala Val Ser Thr Gly Leu Thr
     930                 935                 940

 ggg gct gtg aac ttg gcc aaa ggg act gtc cag acc ggc gtg gac acc     2880
 Gly Ala Val Asn Leu Ala Lys Gly Thr Val Gln Thr Gly Val Asp Thr
 945                 950                 955                 960

 agc aag act gtc ctg acc ggt acc aag gac acc gtc tgc agt gga gtc     2928
 Ser Lys Thr Val Leu Thr Gly Thr Lys Asp Thr Val Cys Ser Gly Val
                 965                 970                 975

 act ggt gcc gta aat gtg gcc aaa ggg acc gtc cag aca ggt gtg gac     2976
 Thr Gly Ala Val Asn Val Ala Lys Gly Thr Val Gln Thr Gly Val Asp
             980                 985                 990

 aca gcc aag acg gtg ctg agt ggc gct aag gat gca gtg act act gga     3024
 Thr Ala Lys Thr Val Leu Ser Gly Ala Lys Asp Ala Val Thr Thr Gly
         995                1000                1005

 gtc acg ggg gca gtg aat gtg gcc aaa gga acc gtg cag acc ggc gtg     3072
 Val Thr Gly Ala Val Asn Val Ala Lys Gly Thr Val Gln Thr Gly Val
    1010                1015                1020

 gac gcc tcc aag gct gtg ctt atg ggt acc aag gac act gtc ttc agt     3120
 Asp Ala Ser Lys Ala Val Leu Met Gly Thr Lys Asp Thr Val Phe Ser
1025                1030                1035                1040

 ggg gtt acc ggt gcc atg agc atg gcc aaa ggg gcc gtc cag ggg ggc     3168
 Gly Val Thr Gly Ala Met Ser Met Ala Lys Gly Ala Val Gln Gly Gly
                1045                1050                1055

 ctg gac acc acc aag aca gtg ctg acc gga acc aaa gac gca gtg tcc     3216
 Leu Asp Thr Thr Lys Thr Val Leu Thr Gly Thr Lys Asp Ala Val Ser
            1060                1065                1070

 gct ggg ctc atg ggg tca ggg aac gtg gcg aca ggg gcc acc cac act     3264
 Ala Gly Leu Met Gly Ser Gly Asn Val Ala Thr Gly Ala Thr His Thr
        1075                1080                1085

 ggc ctc agc acc ttc cag aac tgg tta cct agt acc ccc gcc acc tcc     3312
 Gly Leu Ser Thr Phe Gln Asn Trp Leu Pro Ser Thr Pro Ala Thr Ser
    1090                1095                1100

 tgg ggt gga ctc acc agt tcc agg acc aca gac aat ggt ggg gag cag     3360
 Trp Gly Gly Leu Thr Ser Ser Arg Thr Thr Asp Asn Gly Gly Glu Gln
1105                1110                1115                1120

 act gcc ctg agc ccc caa gag gcc ccg ttc tct ggc atc tcc acg ccc     3408
 Thr Ala Leu Ser Pro Gln Glu Ala Pro Phe Ser Gly Ile Ser Thr Pro
                1125                1130                1135

 ccg gat gtg ctc agt gta ggc ccg gag cct gcc tgg gaa gcc gca gcc     3456
 Pro Asp Val Leu Ser Val Gly Pro Glu Pro Ala Trp Glu Ala Ala Ala
            1140                1145                1150

 act acc aag ggc ctt gcg act gac gtg gcg acg ttc acc caa ggg gcc     3504
 Thr Thr Lys Gly Leu Ala Thr Asp Val Ala Thr Phe Thr Gln Gly Ala
        1155                1160                1165

 gcc cca ggc agg gag gac acg ggg ctt ttg gcc acc aca cac ggc ccc     3552
 Ala Pro Gly Arg Glu Asp Thr Gly Leu Leu Ala Thr Thr His Gly Pro
    1170                1175                1180

 gaa gaa gcc cca cgc ttg gca atg ctg cag aat gag ttg gag ggg ctg     3600
 Glu Glu Ala Pro Arg Leu Ala Met Leu Gln Asn Glu Leu Glu Gly Leu
1185                1190                1195                1200

 ggg gac atc ttc cac ccc atg aat gcg gag gag caa gct cag ctg gct     3648
 Gly Asp Ile Phe His Pro Met Asn Ala Glu Glu Gln Ala Gln Leu Ala
                1205                1210                1215

 gcc tcc cag cct ggg cca aag gtg ctg tcg gcg gaa cag ggg agc tac     3696
 Ala Ser Gln Pro Gly Pro Lys Val Leu Ser Ala Glu Gln Gly Ser Tyr
            1220                1225                1230

 ttc gtt cgt tta ggt gac ctg ggt ccc agc ttc cgc cag cgg gca ttt     3744
 Phe Val Arg Leu Gly Asp Leu Gly Pro Ser Phe Arg Gln Arg Ala Phe
        1235                1240                1245

 gaa cac gcg gtg agc cac ctg cag cac ggc cag ttc caa gcc agg gac     3792
 Glu His Ala Val Ser His Leu Gln His Gly Gln Phe Gln Ala Arg Asp
    1250                1255                1260

 act ctg gcc cag ctc cag gac tgc ttc agg ctg att gaa aag gcc cag     3840
 Thr Leu Ala Gln Leu Gln Asp Cys Phe Arg Leu Ile Glu Lys Ala Gln
1265                1270                1275                1280

 cag gct cca gaa ggg cag cca cgt ctg gac cag ggc tca ggt gcc agt     3888
 Gln Ala Pro Glu Gly Gln Pro Arg Leu Asp Gln Gly Ser Gly Ala Ser
                1285                1290                1295

 gcg gag gac gct gct gtc cag gag gag cgg gat gcc ggg gtt ctg tcc     3936
 Ala Glu Asp Ala Ala Val Gln Glu Glu Arg Asp Ala Gly Val Leu Ser
            1300                1305                1310

 agg gtc tgc ggc ctt ctc cgg cag ctg cac acg gcc tac agt ggc ctg     3984
 Arg Val Cys Gly Leu Leu Arg Gln Leu His Thr Ala Tyr Ser Gly Leu
        1315                1320                1325

 gtc tcc agc ctc cag ggc ctg ccc gcc gag ctc cag cag cca gtg ggg     4032
 Val Ser Ser Leu Gln Gly Leu Pro Ala Glu Leu Gln Gln Pro Val Gly
    1330                1335                1340

 cgg gcg cgg cac agc ctc tgt gag ctc tat ggc atc gtg gcc tca gct     4080
 Arg Ala Arg His Ser Leu Cys Glu Leu Tyr Gly Ile Val Ala Ser Ala
1345                1350                1355                1360

 ggc tct gta gag gag ctg ccc gca gag cgg ctg gtg cag agc cgc gag     4128
 Gly Ser Val Glu Glu Leu Pro Ala Glu Arg Leu Val Gln Ser Arg Glu
                1365                1370                1375

 ggt gtg cac cag gct tgg cag ggg tta gag cag ctg ctg gag ggc cta     4176
 Gly Val His Gln Ala Trp Gln Gly Leu Glu Gln Leu Leu Glu Gly Leu
            1380                1385                1390

 cag cac aat ccc ccg ctc agc tgg ctg gta ggg ccc ttc gcc ttg ccc     4224
 Gln His Asn Pro Pro Leu Ser Trp Leu Val Gly Pro Phe Ala Leu Pro
        1395                1400                1405

 gct ggc ggg cag tag                                                 4239
 Ala Gly Gly Gln 
    1410





      <210> 479
      <211> 2502
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (791)..(1585)

      <400> 479
 gagcgacgcc cacggcctgt ctcggccacc agcgtgttcc agcgagcgcc cagccacctc     60

 gctcgcagcc tccccagcgc agcagcccgg ctgtgggcct gcggcagccg ggtcttcctg    120

 gtccccacct cctggggccg acgggcggca ggaaggggct cggcgggacg cgccgtcagg    180

 gacctgagga ggaacaacgg aacgcgttcg gaacggcctg gactcccgag actcacccga    240

 ctcgtggcca caccgggaga actgaagcgg cagtagccgg cggagacgcc cgacccgaag    300

 gccggctgct agggagcaga cagctgaacc gcttgccaga cgccgaaacc cagtgacgcc    360

 ctccaccgct ccaccgtgct cccggctccc cgcccccgcc gcccgcgggc cccaaggcgc    420

 atgcgccgcc tgtcctggag gggcccattt ccttccgtcg tggggggagg cacagtgagt    480

 ccactggggc acggcagcgt ctaagccaca agccgagcac ataagccagg tcctaacgga    540

 gcctatgtgt aagtccacta ctggtgcaag gttgcacact tctaagaaga gcggcgtggg    600

 gggctcggcg accttcgctt cagtcgctcc cccgtgcagt cccctgtgcc caagacacag    660

 cctgatgctt gtgctccggt gggcggggct tggaggcggc gggaactgca attggtggct    720

 ttgaaggcgc ggcgagcggg aacagctctt gaggagtgag actgcaggag atgtgggccg    780

 tgccaaagag   atg gat gag act gtt gct gag ttc atc aag agg acc atc     829
              Met Asp Glu Thr Val Ala Glu Phe Ile Lys Arg Thr Ile
                1               5                  10

 ttg aaa atc ccc atg aat gaa ctg aca aca atc ctg aag gcc tgg gat      877
 Leu Lys Ile Pro Met Asn Glu Leu Thr Thr Ile Leu Lys Ala Trp Asp
      15                  20                  25

 ttt ttg tct gaa aat caa ctg cag act gta aat ttc cga cag aga aag      925
 Phe Leu Ser Glu Asn Gln Leu Gln Thr Val Asn Phe Arg Gln Arg Lys
  30                  35                  40                  45

 gaa tct gta gtt cag cac ttg atc cat ctg tgt gag gaa aag cgt gca      973
 Glu Ser Val Val Gln His Leu Ile His Leu Cys Glu Glu Lys Arg Ala
                  50                  55                  60

 agt atc agt gat gct gcc ctg tta gac atc att tat atg caa ttt cat     1021
 Ser Ile Ser Asp Ala Ala Leu Leu Asp Ile Ile Tyr Met Gln Phe His
              65                  70                  75

 cag cac cag aaa gtt tgg gat gtt ttt cag atg agt aaa gga cca ggt     1069
 Gln His Gln Lys Val Trp Asp Val Phe Gln Met Ser Lys Gly Pro Gly
          80                  85                  90

 gaa gat gtt gac ctt ttt gat atg aaa caa ttt aaa aat tcg ttc aag     1117
 Glu Asp Val Asp Leu Phe Asp Met Lys Gln Phe Lys Asn Ser Phe Lys
      95                 100                 105

 aaa att ctt cag aga gca tta aaa aat gtg aca gtc agc ttc aga gaa     1165
 Lys Ile Leu Gln Arg Ala Leu Lys Asn Val Thr Val Ser Phe Arg Glu
 110                 115                 120                 125

 act gag gag aat gca gtc tgg att cga att gcc tgg gga aca cag tac     1213
 Thr Glu Glu Asn Ala Val Trp Ile Arg Ile Ala Trp Gly Thr Gln Tyr
                 130                 135                 140

 aca aag cca aac cag tac aaa cct acc tac gtg gtg tac tac tcc cag     1261
 Thr Lys Pro Asn Gln Tyr Lys Pro Thr Tyr Val Val Tyr Tyr Ser Gln
             145                 150                 155

 act ccg tac gcc ttc acg tcc tcc tcc atg ctg agg cgc aat aca ccg     1309
 Thr Pro Tyr Ala Phe Thr Ser Ser Ser Met Leu Arg Arg Asn Thr Pro
         160                 165                 170

 ctt ctg ggt cag gcg ctg aca att gct agc aaa cac cat cag att gtg     1357
 Leu Leu Gly Gln Ala Leu Thr Ile Ala Ser Lys His His Gln Ile Val
     175                 180                 185

 aaa atg gac ctg aga agt cgg tat ctg gac tct ctt aag gct att gtt     1405
 Lys Met Asp Leu Arg Ser Arg Tyr Leu Asp Ser Leu Lys Ala Ile Val
 190                 195                 200                 205

 ttt aaa cag tat aat cag acc ttt gaa act cac aac tct acg aca cct     1453
 Phe Lys Gln Tyr Asn Gln Thr Phe Glu Thr His Asn Ser Thr Thr Pro
                 210                 215                 220

 cta cag gaa aga agc ctt gga cta gat ata aat atg gat tca agg atc     1501
 Leu Gln Glu Arg Ser Leu Gly Leu Asp Ile Asn Met Asp Ser Arg Ile
             225                 230                 235

 att cat gaa aac ata gta gaa aaa gag aga gtc caa acg aat aac tca     1549
 Ile His Glu Asn Ile Val Glu Lys Glu Arg Val Gln Thr Asn Asn Ser
         240                 245                 250

 aga aca cat ttg gag att atc ctc aac cac aac tag gaat tgcacaatat     1599
 Arg Thr His Leu Glu Ile Ile Leu Asn His Asn 
     255                 260

 aagcttgaaa cgaaattcaa aagtggttga aatgggagca tcttggctga gaggaaagaa   1659

 cccctccgat gcctaataaa gttctctagc ccacatcttc tggaagcatt gaaatcctta   1719

 gcaccagcgg gtattgcaga tgctccactt tctccactgc tcacttgcat acccaacaag   1779

 agaatgaatt attttaaaga ttagagataa ataagacgtg cgtggtttct taagcacagc   1839

 tcctccttct tgatattgca catgcacttc agttcatggc tagctgtata gcttccgtct   1899

 gtaaacttgt attttcaaga atccttggta ttgaattttt agaaatgctc acataattgt   1959

 tgggactgat tcattcctcc acgatatgcc tcctctctct gatatcctgc taactgtagc   2019

 cgttgtggca tttgagatga caggacatat atatatatgg ccccacactt gaccttgagt   2079

 gcctgaatgc tctgaaatca agcatatggc acagcgctca agacttttgg gtttgtgtcc   2139

 ttttttctat ggctgtctct tctcaattct ggagaggtct ggttccagtg gctggtttcc   2199

 agggattgat tcttaagctc tggatcacag agagaagcaa caaggaacta tactcaactc   2259

 aaaacttttt aggagaatca tgaaattggt ctattcaaag gatggagttg agtccattct   2319

 gttattgttg caagaggttg catatttggt gagtcagtta tataaaatag tgttcttatt   2379

 gtaaatatga tacttctcat aatctatttt atcatgtgta taacattcaa actgacaaat   2439

 atattgactt atgaataaag gtgtcaaaaa actggcacat cagttaattt tgaaaaaaaa   2499

 aaa                                                                 2502




      <210> 480
      <211> 1222
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (760)..(1206)

      <400> 480
 atggctgaga ttttgctgtt ttgttccctg ctgtgttcac agggcctaga acagggtttt     60

 tatcggtggt cagatgaaca cacgactcca tctccagcgg agccggggaa acgaggcgag    120

 ctgcctgggc agtttggggc caccttctgt ctgccagacc tggtgcgata tgatggacac    180

 tcagcttcca acattcggga aaggcgtgcc cggatcgcga ggggccgctg ggaccgagtc    240

 ccggacgtcg cgacgcgcag ggggctgctg ctgccggcgg tctcgggaaa agtgagggga    300

 cggaggcgcc caagcaacgt gggtttcggg aactgtgagt atttcacttt gcgtagagcc    360

 ccctcgggca atgcgaccca gaaccgaggg cttctttccc ccgccggggc ctccctcccg    420

 ttctccactc ggaacaaaca gcctgcagtt cccgcagctg caggccgggc cgcggaacat    480

 gcgccgggag cggggcccgg gcgggactcc ggagctggta ctgctccccc cgcttcggcg    540

 cgcggcatcg tgcggcctcc ttcctccctg tcctgccgcg ctcggccgga ggcggcggcg    600

 gaggggcgag acgcggccct tcggcggcac ctcctccccg ggcaggcgcg ggcggagccg    660

 ggcgcctcag ccagccgcgg cgggagcagc gcagctgcgg cgccgcgggc agcgcagccg    720

 cattcgaacc tccctcgcaa agacagtctc cgccccaca   atg cac cgc ggc ggg     774
                                              Met His Arg Gly Gly
                                                1               5

 cag cct ttg aaa aag cgg cgc ggc tcg ttc aag atg gcg gag ctc gac      822
 Gln Pro Leu Lys Lys Arg Arg Gly Ser Phe Lys Met Ala Glu Leu Asp
                  10                  15                  20

 cag ttg cct gac gag agc tct tca gca aaa gcc ctt gtc agt tta aaa      870
 Gln Leu Pro Asp Glu Ser Ser Ser Ala Lys Ala Leu Val Ser Leu Lys
              25                  30                  35

 gaa gga agc tta tct aac acg tgg aat gaa aag tac agt tct tta cag      918
 Glu Gly Ser Leu Ser Asn Thr Trp Asn Glu Lys Tyr Ser Ser Leu Gln
          40                  45                  50

 aaa aca cct gtt tgg aaa ggc agg aat aca agc tct gct gtg gaa atg      966
 Lys Thr Pro Val Trp Lys Gly Arg Asn Thr Ser Ser Ala Val Glu Met
      55                  60                  65

 cct ttc aga aat tca aaa cga agt cga ctt ttt tct gat gaa gat gat     1014
 Pro Phe Arg Asn Ser Lys Arg Ser Arg Leu Phe Ser Asp Glu Asp Asp
  70                  75                  80                  85

 agg caa ata aat aca agg tca cct aaa aga aac cag agg gtt gca atg     1062
 Arg Gln Ile Asn Thr Arg Ser Pro Lys Arg Asn Gln Arg Val Ala Met
                  90                  95                 100

 gtt cca cag aaa ttt aca gca aca atg tca aca cca gat aag aaa gct     1110
 Val Pro Gln Lys Phe Thr Ala Thr Met Ser Thr Pro Asp Lys Lys Ala
             105                 110                 115

 tca cag aag att ggt ttt cga tta cgt aat ctg ctc aag ctt cct aaa     1158
 Ser Gln Lys Ile Gly Phe Arg Leu Arg Asn Leu Leu Lys Leu Pro Lys
         120                 125                 130

 gca cat aaa tgg tgt ata tac gag tgg ttc tat tca aaa aat aaa taa     1206
 Ala His Lys Trp Cys Ile Tyr Glu Trp Phe Tyr Ser Lys Asn Lys 
     135                 140                 145

 cccacttttg gagggg                                                   1222




      <210> 481
      <211> 1393
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (67)..(1053)

      <400> 481
 atgaagatga tcaaggctct agcagatgtc tgtccagagg aagatggtgt gaaagtagat     60

 gtcatt   atg gtg ttc cag ttc ccc tct act gaa caa agg gca gta aga     108
          Met Val Phe Gln Phe Pro Ser Thr Glu Gln Arg Ala Val Arg
            1               5                  10

 gag aag aaa atc caa agc atc tta aat cag aag ata agg aat tta aga      156
 Glu Lys Lys Ile Gln Ser Ile Leu Asn Gln Lys Ile Arg Asn Leu Arg
  15                  20                  25                  30

 gcc ttg cca ata aat gcc tca tca gtt caa gtt aat gtg gcc atg gtc      204
 Ala Leu Pro Ile Asn Ala Ser Ser Val Gln Val Asn Val Ala Met Val
                  35                  40                  45

 aag aat ggc aat gtg ggg cca ggt tcc gga gca gga gag gct cca ggc      252
 Lys Asn Gly Asn Val Gly Pro Gly Ser Gly Ala Gly Glu Ala Pro Gly
              50                  55                  60

 ctg gga gca ggt cct gcc tgg tca cca atg agc tca tca aca ggg gag      300
 Leu Gly Ala Gly Pro Ala Trp Ser Pro Met Ser Ser Ser Thr Gly Glu
          65                  70                  75

 tta act gtc caa gca agt tgt ggt aaa cga gtt gtt cca tta aac gtc      348
 Leu Thr Val Gln Ala Ser Cys Gly Lys Arg Val Val Pro Leu Asn Val
      80                  85                  90

 aac aga ata gca tct gga gtc att gca ccc aag gcg gcc tgg cct tgg      396
 Asn Arg Ile Ala Ser Gly Val Ile Ala Pro Lys Ala Ala Trp Pro Trp
  95                 100                 105                 110

 caa gct tcc ctt cag tat gat aac atc cat cag tgt ggg gcc acc ttg      444
 Gln Ala Ser Leu Gln Tyr Asp Asn Ile His Gln Cys Gly Ala Thr Leu
                 115                 120                 125

 att agt aac aca tgg ctt gtc act gca gca cac tgc ttc cag aag tat      492
 Ile Ser Asn Thr Trp Leu Val Thr Ala Ala His Cys Phe Gln Lys Tyr
             130                 135                 140

 aaa aat cca cat caa tgg act gtt agt ttt gga aca aaa atc aac cct      540
 Lys Asn Pro His Gln Trp Thr Val Ser Phe Gly Thr Lys Ile Asn Pro
         145                 150                 155

 ccc tta atg aaa aga aat gtc aga aga ttt att atc cat gag aag tac      588
 Pro Leu Met Lys Arg Asn Val Arg Arg Phe Ile Ile His Glu Lys Tyr
     160                 165                 170

 cgc tct gca gca aga gag tac gac att gct gtt gtg cag gtc tct tcc      636
 Arg Ser Ala Ala Arg Glu Tyr Asp Ile Ala Val Val Gln Val Ser Ser
 175                 180                 185                 190

 aga gtc acc ttt tcg gat gac ata cgc cag att tgt ttg cca gaa gcc      684
 Arg Val Thr Phe Ser Asp Asp Ile Arg Gln Ile Cys Leu Pro Glu Ala
                 195                 200                 205

 tct gca tcc ttc caa cca aat ttg act gtc cac atc aca gga ttt gga      732
 Ser Ala Ser Phe Gln Pro Asn Leu Thr Val His Ile Thr Gly Phe Gly
             210                 215                 220

 gca ctt tac tat ggt ggg gaa tcc caa aat gat ctc cga gaa gcc aga      780
 Ala Leu Tyr Tyr Gly Gly Glu Ser Gln Asn Asp Leu Arg Glu Ala Arg
         225                 230                 235

 gtg aaa atc ata agt gat gat gtc tgc aag caa cca cag gtg tat ggc      828
 Val Lys Ile Ile Ser Asp Asp Val Cys Lys Gln Pro Gln Val Tyr Gly
     240                 245                 250

 aat gat ata aaa cct gga atg ttc tgt gcc gga tat atg gaa gga att      876
 Asn Asp Ile Lys Pro Gly Met Phe Cys Ala Gly Tyr Met Glu Gly Ile
 255                 260                 265                 270

 tat gat gcc tgc agg ggt gat tct ggg gga cct tta gtc aca agg gat      924
 Tyr Asp Ala Cys Arg Gly Asp Ser Gly Gly Pro Leu Val Thr Arg Asp
                 275                 280                 285

 ctg aaa gat acg tgg tat ctc att gga att gta agc tgg gga gat aac      972
 Leu Lys Asp Thr Trp Tyr Leu Ile Gly Ile Val Ser Trp Gly Asp Asn
             290                 295                 300

 tgt ggt caa aag gac aag cct gga gtc tac aca caa gtg act tat tac     1020
 Cys Gly Gln Lys Asp Lys Pro Gly Val Tyr Thr Gln Val Thr Tyr Tyr
         305                 310                 315

 cga aac tgg att gct tca aaa aca ggc atc taa ttcacgat aaaagttaaa     1071
 Arg Asn Trp Ile Ala Ser Lys Thr Gly Ile 
     320                 325

 caaagaaagc tgtatgcagg tcatatatgc atgagaattc aactatttag tgggtgtagt   1131

 acaacaaagt gatattaaat tactggatct agtaacatga aacacacaac gtaagttatt   1191

 tagaatcact ttaatcaacc aataatcctt agccaattta taagggactt ttatttgtaa   1251

 agtaatggat ctggcttgaa aaatacggta gagatactta gctctttaaa tcacgaatgt   1311

 tgaagtacca gtgagactca atacatattt ttgaagatag tccatgggat ttttagaatg   1371

 tcgttgtcaa gggtctcctt tg                                            1393




      <210> 482
      <211> 937
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (35)..(937)

      <400> 482
 tccagaggaa gatggtgtga aagtagatgt catt    atg gtg ttc cag ttc ccc      52
                                          Met Val Phe Gln Phe Pro
                                            1               5

 tct act gaa caa agg gca gta aga gag aag aaa atc caa agc atc tta      100
 Ser Thr Glu Gln Arg Ala Val Arg Glu Lys Lys Ile Gln Ser Ile Leu
              10                  15                  20

 aat cag aag ata agg aat tta aga gcc ttg cca ata aat gcc tca tca      148
 Asn Gln Lys Ile Arg Asn Leu Arg Ala Leu Pro Ile Asn Ala Ser Ser
          25                  30                  35

 gtt caa gtt aat gca atg agc tca tca aca ggg gag tta act gtc caa      196
 Val Gln Val Asn Ala Met Ser Ser Ser Thr Gly Glu Leu Thr Val Gln
      40                  45                  50

 gca agt tgt ggt aaa cga gtt gtt cca tta aac gtc aac aga ata gca      244
 Ala Ser Cys Gly Lys Arg Val Val Pro Leu Asn Val Asn Arg Ile Ala
  55                  60                  65                  70

 tct gga gtc att gca ccc aag gcg gcc tgg cct tgg caa gct tcc ctt      292
 Ser Gly Val Ile Ala Pro Lys Ala Ala Trp Pro Trp Gln Ala Ser Leu
                  75                  80                  85

 cag tat gat aac atc cat cag tgt ggg gcc acc ttg att agt aac aca      340
 Gln Tyr Asp Asn Ile His Gln Cys Gly Ala Thr Leu Ile Ser Asn Thr
              90                  95                 100

 tgg ctt gtc act gca gca cac tgc ttc cag aag tat aaa aat cca cat      388
 Trp Leu Val Thr Ala Ala His Cys Phe Gln Lys Tyr Lys Asn Pro His
         105                 110                 115

 caa tgg act gtt agt ttt gga aca aaa atc aac cct ccc tta atg aaa      436
 Gln Trp Thr Val Ser Phe Gly Thr Lys Ile Asn Pro Pro Leu Met Lys
     120                 125                 130

 aga aat gtc aga aga ttt att atc cat gag aag tac cgc tct gca gca      484
 Arg Asn Val Arg Arg Phe Ile Ile His Glu Lys Tyr Arg Ser Ala Ala
 135                 140                 145                 150

 aga gag tac gac att gct gtt gtg cag gtc tct tcc aga gtc acc ttt      532
 Arg Glu Tyr Asp Ile Ala Val Val Gln Val Ser Ser Arg Val Thr Phe
                 155                 160                 165

 tcg gat gac ata cgc cgg att tgt ttg cca gaa gcc tct gca tcc ttc      580
 Ser Asp Asp Ile Arg Arg Ile Cys Leu Pro Glu Ala Ser Ala Ser Phe
             170                 175                 180

 caa cca aat ttg act gtc cac atc aca gga ttt gga gca ctt tac tat      628
 Gln Pro Asn Leu Thr Val His Ile Thr Gly Phe Gly Ala Leu Tyr Tyr
         185                 190                 195

 ggt ggg gaa tcc caa aat gat ctc cga gaa gcc aga gtg aaa atc ata      676
 Gly Gly Glu Ser Gln Asn Asp Leu Arg Glu Ala Arg Val Lys Ile Ile
     200                 205                 210

 agt gat gat gtc tgc aag caa cca cag gtg tat ggc aat gat ata aaa      724
 Ser Asp Asp Val Cys Lys Gln Pro Gln Val Tyr Gly Asn Asp Ile Lys
 215                 220                 225                 230

 cct gga atg ttc tgt gcc gga tat atg gaa gga att tat gat gcc tgc      772
 Pro Gly Met Phe Cys Ala Gly Tyr Met Glu Gly Ile Tyr Asp Ala Cys
                 235                 240                 245

 agg ggt gat tct ggg gga cct tta gtc aca agg gat ctg aaa gat acg      820
 Arg Gly Asp Ser Gly Gly Pro Leu Val Thr Arg Asp Leu Lys Asp Thr
             250                 255                 260

 tgg tat ctc att gga att gta agc tgg gga gat aac tgt ggt caa aag      868
 Trp Tyr Leu Ile Gly Ile Val Ser Trp Gly Asp Asn Cys Gly Gln Lys
         265                 270                 275

 gac aag cct gga gtc tac aca caa gtg act tat tac cga aac tgg att      916
 Asp Lys Pro Gly Val Tyr Thr Gln Val Thr Tyr Tyr Arg Asn Trp Ile
     280                 285                 290

 gct tca aaa aca ggc atc taa                                          937
 Ala Ser Lys Thr Gly Ile 
 295                 300





      <210> 483
      <211> 1251
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1251)

      <400> 483
  atg ttt gca ctg ttc aag aaa aaa aaa cag gac gcg ggt ttg aat gga      48
  Met Phe Ala Leu Phe Lys Lys Lys Lys Gln Asp Ala Gly Leu Asn Gly
    1               5                  10                  15

 ata act gaa cgt tac gtg gtt gat ttt cag tgc aac ttc cct gca atc       96
 Ile Thr Glu Arg Tyr Val Val Asp Phe Gln Cys Asn Phe Pro Ala Ile
              20                  25                  30

 cgt gcc ccc aga atg cgg agg cgc ctt gct gtg ggg agg cgc tgt gag      144
 Arg Ala Pro Arg Met Arg Arg Arg Leu Ala Val Gly Arg Arg Cys Glu
          35                  40                  45

 gag gcg ctg agt act ggt gag aca ctg aac tgt gag gag gtg ctg tgc      192
 Glu Ala Leu Ser Thr Gly Glu Thr Leu Asn Cys Glu Glu Val Leu Cys
      50                  55                  60

 tgt gag gag atg ctg aac tgt gag gag gcg ctg agc tgt gag gag gcg      240
 Cys Glu Glu Met Leu Asn Cys Glu Glu Ala Leu Ser Cys Glu Glu Ala
  65                  70                  75                  80

 ctg agc tgt gag gag gcg ctg agc tgt gag gag gca ctg agc tgt gag      288
 Leu Ser Cys Glu Glu Ala Leu Ser Cys Glu Glu Ala Leu Ser Cys Glu
                  85                  90                  95

 gtg ctg agc tgt gag gag atg ctg aac tgt gag gag gcg ctg tgc tgt      336
 Val Leu Ser Cys Glu Glu Met Leu Asn Cys Glu Glu Ala Leu Cys Cys
             100                 105                 110

 ggg gag gcg ctg agc tgt gag gag gcg ctg tgc atg agg gag gcg ctg      384
 Gly Glu Ala Leu Ser Cys Glu Glu Ala Leu Cys Met Arg Glu Ala Leu
         115                 120                 125

 ggc cgt ggg gag gcg ctg ggc agt ggg gag gcg ctg ggc agt ggg gag      432
 Gly Arg Gly Glu Ala Leu Gly Ser Gly Glu Ala Leu Gly Ser Gly Glu
     130                 135                 140

 gcg ctg tgc agt ggg gag gcg ctg tgc cgt ggg gag gcg ctg ggc agt      480
 Ala Leu Cys Ser Gly Glu Ala Leu Cys Arg Gly Glu Ala Leu Gly Ser
 145                 150                 155                 160

 gag gag gcg ctg tgc agt gag gag gcg ctg tgc agt gag gag gtg ctg      528
 Glu Glu Ala Leu Cys Ser Glu Glu Ala Leu Cys Ser Glu Glu Val Leu
                 165                 170                 175

 tgc cgt ggg gag gcg ctg ggc agt gag gag gcg ctg tgc agt gag gag      576
 Cys Arg Gly Glu Ala Leu Gly Ser Glu Glu Ala Leu Cys Ser Glu Glu
             180                 185                 190

 gcg ctg ggc agt gag gag gtg ctg tgc cgt ggg gag gcg ctg aac tgt      624
 Ala Leu Gly Ser Glu Glu Val Leu Cys Arg Gly Glu Ala Leu Asn Cys
         195                 200                 205

 gag gag gcg ctg tgc ctt ggg gag gcg ctg aac tgt ggg cag gca cta      672
 Glu Glu Ala Leu Cys Leu Gly Glu Ala Leu Asn Cys Gly Gln Ala Leu
     210                 215                 220

 aac tgt gac gag gca ctg tgc agt gag gag gcg ctg tgc agc ctt cag      720
 Asn Cys Asp Glu Ala Leu Cys Ser Glu Glu Ala Leu Cys Ser Leu Gln
 225                 230                 235                 240

 cag atg ctt gtt gag gaa tgg atg aac ggc ccc aac tgt atc att gga      768
 Gln Met Leu Val Glu Glu Trp Met Asn Gly Pro Asn Cys Ile Ile Gly
                 245                 250                 255

 tgt aaa ggc cga aga att cca aat gac gtt ctg gcc tct gaa atg aga      816
 Cys Lys Gly Arg Arg Ile Pro Asn Asp Val Leu Ala Ser Glu Met Arg
             260                 265                 270

 aat cag gag aga cgt cct gga gac agg gaa ctt cag gtg gtc ttt gaa      864
 Asn Gln Glu Arg Arg Pro Gly Asp Arg Glu Leu Gln Val Val Phe Glu
         275                 280                 285

 atc tgt tca gtg ttg aag cca aaa tgt gat gaa gtg aag aga aac tca      912
 Ile Cys Ser Val Leu Lys Pro Lys Cys Asp Glu Val Lys Arg Asn Ser
     290                 295                 300

 cat tca ggc cac agc aga ata act gaa cct gct gca tca gcc tca gag      960
 His Ser Gly His Ser Arg Ile Thr Glu Pro Ala Ala Ser Ala Ser Glu
 305                 310                 315                 320

 cca gcc tgg ggc ctg ccg ggg gct cac tct gac ctg gag gtg gcc aca     1008
 Pro Ala Trp Gly Leu Pro Gly Ala His Ser Asp Leu Glu Val Ala Thr
                 325                 330                 335

 gga gct gct gga aga agg tat ggc tgt tgc cct ttc ttc cag aaa gtg     1056
 Gly Ala Ala Gly Arg Arg Tyr Gly Cys Cys Pro Phe Phe Gln Lys Val
             340                 345                 350

 cat ccc cca cac cct ggt gga agc tgc atc ccc cac tgc atc tct ggt     1104
 His Pro Pro His Pro Gly Gly Ser Cys Ile Pro His Cys Ile Ser Gly
         355                 360                 365

 gca ggc cag cca gca ccc acc aag gtt cgc atg ctc caa gga gag gga     1152
 Ala Gly Gln Pro Ala Pro Thr Lys Val Arg Met Leu Gln Gly Glu Gly
     370                 375                 380

 gaa gca aga gtc agt gaa act tgc cgc ctg caa atc cag gac act gca     1200
 Glu Ala Arg Val Ser Glu Thr Cys Arg Leu Gln Ile Gln Asp Thr Ala
 385                 390                 395                 400

 agc cag aaa gtt att ttt ctg ttc cat ttc acc tcc aag ctg aat tat     1248
 Ser Gln Lys Val Ile Phe Leu Phe His Phe Thr Ser Lys Leu Asn Tyr
                 405                 410                 415

 tga                                                                 1251
 






      <210> 484
      <211> 960
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (209)..(913)

      <400> 484
 ggaattttca ggcgccgcag tgtctacacc cgcaaaaacg cccgctttga cttagagccc     60

 tccgcatatc cttcccctgg ctggggcagc caaggcgcgg aggacagctc cgaggccaga    120

 tgtttactgc gcagatgccc gactttacac cggggtccgg gctgtgccgg gcgctggggg    180

 aagcgcccac cttccagaga gcgaaatc   atg gag cct tcc aag acc ttc atg     232
                                  Met Glu Pro Ser Lys Thr Phe Met
                                    1               5

 aga aac ctg cca atc aca cca ggc tat agc ggc ttt gtg cca ttc ctc      280
 Arg Asn Leu Pro Ile Thr Pro Gly Tyr Ser Gly Phe Val Pro Phe Leu
      10                  15                  20

 agc tgc caa gga atg tcc aag gag gat gac atg aac cac tgt gtg aaa      328
 Ser Cys Gln Gly Met Ser Lys Glu Asp Asp Met Asn His Cys Val Lys
  25                  30                  35                  40

 acc ttc cag gag aaa aca cag cgc tat aaa gaa cag ctg cgg gaa ttg      376
 Thr Phe Gln Glu Lys Thr Gln Arg Tyr Lys Glu Gln Leu Arg Glu Leu
                  45                  50                  55

 tgc tgc gca gtg gcc act gcc ccg aaa ctg aaa cct gtc aac tcc gag      424
 Cys Cys Ala Val Ala Thr Ala Pro Lys Leu Lys Pro Val Asn Ser Glu
              60                  65                  70

 gag acg gtc ctg cag gcc ctg cac cag tac aat ctg cag tac cac ccc      472
 Glu Thr Val Leu Gln Ala Leu His Gln Tyr Asn Leu Gln Tyr His Pro
          75                  80                  85

 ctg atc ctg gaa tgc aaa tat gta aag aaa cct ctc cag gag ccc ccg      520
 Leu Ile Leu Glu Cys Lys Tyr Val Lys Lys Pro Leu Gln Glu Pro Pro
      90                  95                 100

 atc cct ggc tgg gca ggc tac ctg ccg aga gcc aag gtc act gaa ttt      568
 Ile Pro Gly Trp Ala Gly Tyr Leu Pro Arg Ala Lys Val Thr Glu Phe
 105                 110                 115                 120

 ggc tgt ggc acg aga tac act gtc atg gcc aaa aac tgc tac aag gac      616
 Gly Cys Gly Thr Arg Tyr Thr Val Met Ala Lys Asn Cys Tyr Lys Asp
                 125                 130                 135

 ttc ctg gag atc acg gag agg gcc aag aag gca cat ctg aaa cca tat      664
 Phe Leu Glu Ile Thr Glu Arg Ala Lys Lys Ala His Leu Lys Pro Tyr
             140                 145                 150

 gaa gaa ata tat gga gtt agc tcc aca aaa act tct gct ccg tct cca      712
 Glu Glu Ile Tyr Gly Val Ser Ser Thr Lys Thr Ser Ala Pro Ser Pro
         155                 160                 165

 aaa gtt ttg cag cat gaa gag ctg ctg cca aaa tat ccc gat ttt tct      760
 Lys Val Leu Gln His Glu Glu Leu Leu Pro Lys Tyr Pro Asp Phe Ser
     170                 175                 180

 att cca gat gga agc tgc cct gcc ctt gga agg ccc ctg aga gag gac      808
 Ile Pro Asp Gly Ser Cys Pro Ala Leu Gly Arg Pro Leu Arg Glu Asp
 185                 190                 195                 200

 ccc aaa act ccg ctg aca tgt ggc tgt gct cag agg cca agt ata cca      856
 Pro Lys Thr Pro Leu Thr Cys Gly Cys Ala Gln Arg Pro Ser Ile Pro
                 205                 210                 215

 tgc agt ggg aag atg tat cta gag cca ctg tcc tcc gca aag tat gca      904
 Cys Ser Gly Lys Met Tyr Leu Glu Pro Leu Ser Ser Ala Lys Tyr Ala
             220                 225                 230

 gaa ggc tag aagcgca gagtctccca aggaggtgaa ctttaagtgg ggcttccaaa      960
 Glu Gly 






      <210> 485
      <211> 415
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (120)..(365)

      <400> 485
 aggcatggga caagaatttg gaacccacca agaatttggg acctgccatt tggcaagcct     60

 gaaagaactg taagacaaac agggctgaaa cttgccccct gctcaccagg tggcaggtg     119                                                                 
 atg agg aga aaa gag ctg cag ccc ttt ggg gag ccc aga cct agg ggc      167
 Met Arg Arg Lys Glu Leu Gln Pro Phe Gly Glu Pro Arg Pro Arg Gly
   1               5                  10                  15

 tct ccg agc gag ggc tgt gac acc atc ttt ggg gct ccg cag tcc ctg      215
 Ser Pro Ser Glu Gly Cys Asp Thr Ile Phe Gly Ala Pro Gln Ser Leu
              20                  25                  30

 gca tct cca agc ttc cag gca cca ccg tgt tcc cag gta ccc acc ttg      263
 Ala Ser Pro Ser Phe Gln Ala Pro Pro Cys Ser Gln Val Pro Thr Leu
          35                  40                  45

 gaa gct gct tgc ggt aca cct gat cca gcc aca gcc tcg cat gga gct      311
 Glu Ala Ala Cys Gly Thr Pro Asp Pro Ala Thr Ala Ser His Gly Ala
      50                  55                  60

 ggc acc tgt acc agc att tgg ggc tgc ctg cct tgc tgc agc cgg cac      359
 Gly Thr Cys Thr Ser Ile Trp Gly Cys Leu Pro Cys Cys Ser Arg His
  65                  70                  75                  80

 acc tga ctgcgcagtg gtcggacccc acactcactc acacacccct cgccactctg       415
 Thr 






      <210> 486
      <211> 1357
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (592)..(1212)

      <400> 486
 gccgcttaat attccctgac atgggtgtgt ggttatttgg atctctattc ttagcctttg     60

 atcccaggca gcaattctca tttcaccacc atttattgaa cgtgttccgt gtgtgaagca    120

 cctgcacaca tgagctcctt tcatcttaag cacacaccac acacctatat ccttattcat    180

 tctcatttca caggcaagga agctgaagtt agaggaatca ggctgctttc cccaggttac    240

 ctgaataaca ggtgcggagc tgggatttga agcctcattt cagcacctgt gactagtcac    300

 tacatcattc tgcccttcag gtcccttgtg gagaggaagg aggcaaagag gcgatttgat    360

 acactgggat tgtccagtgg gggtcgctcc agcccagagc agttatgtgc ctttcagtgg    420

 gcaaaccacc ctgcctggga gagggttcat tttccccact ctccggcttt catcttaaag    480

 cccttgccaa acttcagtct gacaaatgat aagagccttg gagacgtcgc tctggtgggt    540

 gtgagctcgc tgccaggttg ctgcttcccg gtgctcacgc tagagatcca t atg ggt     597
                                                          Met Gly
                                                            1

 tgc tct ggg gtt tta aaa aag cgc atc gtg ctc atg tcc tcc att tta      645
 Cys Ser Gly Val Leu Lys Lys Arg Ile Val Leu Met Ser Ser Ile Leu
           5                  10                  15

 cca aag gag gta aat ctg gct ttg gca gca gac aaa gtg cag aga ttt      693
 Pro Lys Glu Val Asn Leu Ala Leu Ala Ala Asp Lys Val Gln Arg Phe
      20                  25                  30

 tta tcc ggc cat gag agc agg cgc tgt cag tgg ctg ggg ctc cct ctt      741
 Leu Ser Gly His Glu Ser Arg Arg Cys Gln Trp Leu Gly Leu Pro Leu
  35                  40                  45                  50

 tca ggc aga gcg gtg gag tgg agg aca gag gca ctg gag ccg gct ttg      789
 Ser Gly Arg Ala Val Glu Trp Arg Thr Glu Ala Leu Glu Pro Ala Leu
                  55                  60                  65

 ctt ctg ccg gtt ttc aaa aac att aag act gtt atg aaa gcc ttt gag      837
 Leu Leu Pro Val Phe Lys Asn Ile Lys Thr Val Met Lys Ala Phe Glu
              70                  75                  80

 ctc att gat gtt aac aag act gga ctg gtt cga ccg cag gag cta aga      885
 Leu Ile Asp Val Asn Lys Thr Gly Leu Val Arg Pro Gln Glu Leu Arg
          85                  90                  95

 agg gtt ctg gag acc ttc tgt atg aag tta aga gac gag gaa tac gaa      933
 Arg Val Leu Glu Thr Phe Cys Met Lys Leu Arg Asp Glu Glu Tyr Glu
     100                 105                 110

 aag ttt tcg aaa cac tac aac atc cac aag gat act gca gta gat tac      981
 Lys Phe Ser Lys His Tyr Asn Ile His Lys Asp Thr Ala Val Asp Tyr
 115                 120                 125                 130

 aac gtg ttt ttg aag aat ctc agc ata aat aac gac ttg aac ctt aga     1029
 Asn Val Phe Leu Lys Asn Leu Ser Ile Asn Asn Asp Leu Asn Leu Arg
                 135                 140                 145

 tat tgt atg gga aat caa gag gtc tca ttg gag aat caa caa gcc aaa     1077
 Tyr Cys Met Gly Asn Gln Glu Val Ser Leu Glu Asn Gln Gln Ala Lys
             150                 155                 160

 aat tcc aaa aag gaa cgt ttg cta ggt tct gca tca tct gaa gat atc     1125
 Asn Ser Lys Lys Glu Arg Leu Leu Gly Ser Ala Ser Ser Glu Asp Ile
         165                 170                 175

 tgg aga aac tac tcc ttg gat gaa att gag agg aac ttt tgt cta caa     1173
 Trp Arg Asn Tyr Ser Leu Asp Glu Ile Glu Arg Asn Phe Cys Leu Gln
     180                 185                 190

 gta aga tgt ttt cct aag cca caa tta cct aca gag taa acacagcaaa      1222
 Val Arg Cys Phe Pro Lys Pro Gln Leu Pro Thr Glu 
 195                 200                 205

 gtagacaata tggaaaacta ttaggtttac acattatttc taaaatttgt ttcgatccta   1282

 cctatgtctt ctccaatact gagaccccct ctacctccca ataacagcaa tacattgatc   1342

 atggataaaa aaaaa                                                    1357




      <210> 487
      <211> 984
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (602)..(880)

      <400> 487
 gcacgagtgg caccctgcgc agaggcgtga gtccctgcct cacactggct cctcccacgc     60

 tgagagaggt cggcgtgacg ccttgcctca caccggcccc tcccacactg accccttggc    120

 tcacaccggc ccctcccacg cagagagagg tcagcgtgac ccttgcctca caccggcccc    180

 tctcacgccg agagaggtca gcgtgagccc ttgcctcaca ccggcccctc ccacgccgag    240

 agaggtcagc gtgagccttg cctcacaccg gcccctccca cgccgagaga ggtcagcgtg    300

 agccctgcct caacaggcca ccgtgaggga ggagcagggc cgtacgcagg ctgccgggag    360

 caggcaggga cttggccgcg ggaggcgttg gtggggcgag aactgggcct ggagacgccc    420

 ctgggaggca acagcggggc ctgctgacgc tcttctgctg ccagagctgg gactgtacag    480

 gccaccggga ggcaggatgt gggcctgaag agcttggctg cagaaacttc ggggtctaca    540

 aacgctggag ggagctgagc caaaagagct tgcctgctgg gaggcaggag ctggccgaga    600

 g    atg cag cca gga gga aca gct ggc ctg cag agc cgc cat gag gga     646
      Met Gln Pro Gly Gly Thr Ala Gly Leu Gln Ser Arg His Glu Gly
        1               5                  10                  15

 ggc aga ggc cgg caa cct caa gtc ggc ctc tcc aga ccc aca tgc ggc      694
 Gly Arg Gly Arg Gln Pro Gln Val Gly Leu Ser Arg Pro Thr Cys Gly
                  20                  25                  30

 ctc ccg gcg tcc tct ccg ggc cca gct ctt cct ccc ggc tgc gtc tcc      742
 Leu Pro Ala Ser Ser Pro Gly Pro Ala Leu Pro Pro Gly Cys Val Ser
              35                  40                  45

 agg ccc gac tgc tgc ctc cca aca acc tct ttg gac tca gcg cct gcc      790
 Arg Pro Asp Cys Cys Leu Pro Thr Thr Ser Leu Asp Ser Ala Pro Ala
          50                  55                  60

 cat ctc ctg gcg gcc ttg gtc ggc cca cag ctt cct caa gcc aag ctc      838
 His Leu Leu Ala Ala Leu Val Gly Pro Gln Leu Pro Gln Ala Lys Leu
      65                  70                  75

 ccc agg ccc agg tca ggc ctc acg gtg gcc tct cca gga tga gctcctg      887
 Pro Arg Pro Arg Ser Gly Leu Thr Val Ala Ser Pro Gly 
  80                  85                  90

 ccctccgatg gcatctccag gccccaaatg gtctccggtc ggtgggctcc tccacgccga    947

 gccctatgca gtctcaaaaa aaaaaaaaaa aagatct                             984




      <210> 488
      <211> 1700
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (93)..(1445)

      <400> 488
 gacccgtccg gaattcccgg gtcgacccac gcgtccgccc acgcgtccgg gctttcacaa     60

 atacagctct gcaacgcgtt tgccctgata cc  atg tct ctt cga ctt tcc agt     113
                                      Met Ser Leu Arg Leu Ser Ser
                                        1               5

 gca tcc agg agg tcc tgt cct cgt ccc acc act gga tca ctc aga ctc      161
 Ala Ser Arg Arg Ser Cys Pro Arg Pro Thr Thr Gly Ser Leu Arg Leu
          10                  15                  20

 tat ggt ggg gga acc agc ttt ggt act gga aat tct tgt ggc att tca      209
 Tyr Gly Gly Gly Thr Ser Phe Gly Thr Gly Asn Ser Cys Gly Ile Ser
      25                  30                  35

 ggg att gga agt ggc ttc tct agt gcc ttc gga ggc agc tca tcg gga      257
 Gly Ile Gly Ser Gly Phe Ser Ser Ala Phe Gly Gly Ser Ser Ser Gly
  40                  45                  50                  55

 gga aac aca ggg gga ggt aat ccc tgt gct gcc ttc act gtg aat gag      305
 Gly Asn Thr Gly Gly Gly Asn Pro Cys Ala Ala Phe Thr Val Asn Glu
                  60                  65                  70

 cgg ggg ctc ctt tct ggc aat gag aag gtg acc atg cag aac ctc aat      353
 Arg Gly Leu Leu Ser Gly Asn Glu Lys Val Thr Met Gln Asn Leu Asn
              75                  80                  85

 gac cgc ctg gca tcc tac ctg gac agt gtg cat gct ctg gag gag gcc      401
 Asp Arg Leu Ala Ser Tyr Leu Asp Ser Val His Ala Leu Glu Glu Ala
          90                  95                 100

 aac gct gac ctg gag cag aag atc aag ggc tgg tat gag aaa ttt ggg      449
 Asn Ala Asp Leu Glu Gln Lys Ile Lys Gly Trp Tyr Glu Lys Phe Gly
     105                 110                 115

 cct ggc tct tgc cgt ggt ctt gat cat gac tat agc aga tat ttc cca      497
 Pro Gly Ser Cys Arg Gly Leu Asp His Asp Tyr Ser Arg Tyr Phe Pro
 120                 125                 130                 135

 ata att gat gac ctt aaa aat cag atc atc gca tcc acc acc agc aat      545
 Ile Ile Asp Asp Leu Lys Asn Gln Ile Ile Ala Ser Thr Thr Ser Asn
                 140                 145                 150

 gct aat gct gtt ctg cag atc gat aat gcc agg ctt aca gct gat gat      593
 Ala Asn Ala Val Leu Gln Ile Asp Asn Ala Arg Leu Thr Ala Asp Asp
             155                 160                 165

 ttc aga ctc aag tat gaa aat gag ctg gct ctt cac cag agt gta gag      641
 Phe Arg Leu Lys Tyr Glu Asn Glu Leu Ala Leu His Gln Ser Val Glu
         170                 175                 180

 gct gat gtc aat ggg tta cga aga gtt ttg gat gaa ata acc ctg tgc      689
 Ala Asp Val Asn Gly Leu Arg Arg Val Leu Asp Glu Ile Thr Leu Cys
     185                 190                 195

 aga aca gat ctg gag att cag tat gaa acc ctg agt gag gag atg act      737
 Arg Thr Asp Leu Glu Ile Gln Tyr Glu Thr Leu Ser Glu Glu Met Thr
 200                 205                 210                 215

 tac ctc aaa aag aac cat aaa gag gaa atg caa gtt ctg cag tgc gca      785
 Tyr Leu Lys Lys Asn His Lys Glu Glu Met Gln Val Leu Gln Cys Ala
                 220                 225                 230

 gct gga ggc aac gtg aac gtg gag atg aac gca gcc ccc ggg gtg gac      833
 Ala Gly Gly Asn Val Asn Val Glu Met Asn Ala Ala Pro Gly Val Asp
             235                 240                 245

 ctc aca gtt ctg ctg aac aac atg cga gct gag tac gaa gcc ctt gca      881
 Leu Thr Val Leu Leu Asn Asn Met Arg Ala Glu Tyr Glu Ala Leu Ala
         250                 255                 260

 gag cag aac cgc agg gac gcg gag gcc tgg ttc aac gag aag agc gcc      929
 Glu Gln Asn Arg Arg Asp Ala Glu Ala Trp Phe Asn Glu Lys Ser Ala
     265                 270                 275

 tcc ctg cag cag cag atc tct gag gat gtc gga gcc aca acc tca gcc      977
 Ser Leu Gln Gln Gln Ile Ser Glu Asp Val Gly Ala Thr Thr Ser Ala
 280                 285                 290                 295

 cgg aat gag ctg act gaa atg aag cgc act ctt caa acc ctg gaa att     1025
 Arg Asn Glu Leu Thr Glu Met Lys Arg Thr Leu Gln Thr Leu Glu Ile
                 300                 305                 310

 gaa ctt cag tct ctc cta gcc acg aaa cac tcc ctg gag tgc tcc ttg     1073
 Glu Leu Gln Ser Leu Leu Ala Thr Lys His Ser Leu Glu Cys Ser Leu
             315                 320                 325

 aca gag acc gag agc aac tac tgt gcg cag ctg gcg cag atc cag gct     1121
 Thr Glu Thr Glu Ser Asn Tyr Cys Ala Gln Leu Ala Gln Ile Gln Ala
         330                 335                 340

 cag atc ggg gcc ctg gag gag cag ctg cac cag gtc aga acc gag acc     1169
 Gln Ile Gly Ala Leu Glu Glu Gln Leu His Gln Val Arg Thr Glu Thr
     345                 350                 355

 gag ggc cag aag ctg gag tat gag cag ctc ctg gac atc aag ctc cac     1217
 Glu Gly Gln Lys Leu Glu Tyr Glu Gln Leu Leu Asp Ile Lys Leu His
 360                 365                 370                 375

 ctg gaa aaa gaa att gag acc tac tgt ctc ctt ata gga gga gat gat     1265
 Leu Glu Lys Glu Ile Glu Thr Tyr Cys Leu Leu Ile Gly Gly Asp Asp
                 380                 385                 390

 gga gcc tgt aag tct ggg ggt tac aag tct aaa gat tat gga tct gga     1313
 Gly Ala Cys Lys Ser Gly Gly Tyr Lys Ser Lys Asp Tyr Gly Ser Gly
             395                 400                 405

 aat gtg gga agt caa gtc aaa gac cca gcc aaa gcc ata gtg gtt aag     1361
 Asn Val Gly Ser Gln Val Lys Asp Pro Ala Lys Ala Ile Val Val Lys
         410                 415                 420

 aaa gtt ctt gag gag gta gac caa cgc agc aaa ata ctt acc acc agg     1409
 Lys Val Leu Glu Glu Val Asp Gln Arg Ser Lys Ile Leu Thr Thr Arg
     425                 430                 435

 ctc cac tcc ctg gaa gag aaa tct caa agc aat taa tttg agatgcaaca     1459
 Leu His Ser Leu Glu Glu Lys Ser Gln Ser Asn 
 440                 445                 450

 gagaacgtat gccacatagc ccctgcgaag aaaaggcatt atgtatctgt ccagaaaaat   1519

 gtgcatgtct aagaaaaatg tctaacctgt tgtctttctg ttactttctt tctgggcaat   1579

 caatgacagc atctccccat tcatctagaa gaatgccaca cacaaatatg actcatttga   1639

 ttatcctaca gaaatctgtt gtcaattctt tgtattcaat aaacctcttc tttagcaagt   1699

 t                                                                   1700




      <210> 489
      <211> 1511
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (93)..(1457)

      <400> 489
 gacccgtccg gaattcccgg gtcgacccac gcgtccgccc acgcgtccgg gctttcacaa     60

 atacagctct gcaacgcgtt tgccctgata cc  atg tct ctt cga ctt tcc agt     113
                                      Met Ser Leu Arg Leu Ser Ser
                                        1               5

 gca tcc agg agg tcc tgt cct cgt ccc acc act gga tca ctc aga ctc      161
 Ala Ser Arg Arg Ser Cys Pro Arg Pro Thr Thr Gly Ser Leu Arg Leu
          10                  15                  20

 tat ggt ggg gga acc agc ttt ggt act gga aat tct tgt ggc att tca      209
 Tyr Gly Gly Gly Thr Ser Phe Gly Thr Gly Asn Ser Cys Gly Ile Ser
      25                  30                  35

 ggg att gga agt ggc ttc tct agt gcc ttc gga ggc agc tca tcg gga      257
 Gly Ile Gly Ser Gly Phe Ser Ser Ala Phe Gly Gly Ser Ser Ser Gly
  40                  45                  50                  55

 gga aac aca ggg gga ggt aat ccc tgt gct gcc ttc act gtg aat gag      305
 Gly Asn Thr Gly Gly Gly Asn Pro Cys Ala Ala Phe Thr Val Asn Glu
                  60                  65                  70

 cgg ggg ctc ctt tct ggc aat gag aag gtg acc atg cag aac ctc aat      353
 Arg Gly Leu Leu Ser Gly Asn Glu Lys Val Thr Met Gln Asn Leu Asn
              75                  80                  85

 gac cgc ctg gca tcc tac ctg gac agt gtg cat gct ctg gag gag gcc      401
 Asp Arg Leu Ala Ser Tyr Leu Asp Ser Val His Ala Leu Glu Glu Ala
          90                  95                 100

 aac gct gac ctg gag cag aag atc aag ggc tgg tat gag aaa ttt ggg      449
 Asn Ala Asp Leu Glu Gln Lys Ile Lys Gly Trp Tyr Glu Lys Phe Gly
     105                 110                 115

 cct ggc tct tgc cgt ggt ctt gat cat gac tat agc aga tat ttc cca      497
 Pro Gly Ser Cys Arg Gly Leu Asp His Asp Tyr Ser Arg Tyr Phe Pro
 120                 125                 130                 135

 ata att gat gac ctt aaa aat cag atc atc gca tcc acc acc agc aat      545
 Ile Ile Asp Asp Leu Lys Asn Gln Ile Ile Ala Ser Thr Thr Ser Asn
                 140                 145                 150

 gct aat gct gtt ctg cag atc gat aat gcc agg ctt aca gct gat gat      593
 Ala Asn Ala Val Leu Gln Ile Asp Asn Ala Arg Leu Thr Ala Asp Asp
             155                 160                 165

 ttc aga ctc aag tat gaa aat gag ctg gct ctt cac cag agt gta gag      641
 Phe Arg Leu Lys Tyr Glu Asn Glu Leu Ala Leu His Gln Ser Val Glu
         170                 175                 180

 gct gat gtc aat ggg tta cga aga gtt ttg gat gaa ata acc ctg tgc      689
 Ala Asp Val Asn Gly Leu Arg Arg Val Leu Asp Glu Ile Thr Leu Cys
     185                 190                 195

 aga aca gat ctg gag att cag tat gaa acc ctg agt gag gag atg act      737
 Arg Thr Asp Leu Glu Ile Gln Tyr Glu Thr Leu Ser Glu Glu Met Thr
 200                 205                 210                 215

 tac ctc aaa aag aac cat aaa gag gaa atg caa gtt ctg cag tgc gca      785
 Tyr Leu Lys Lys Asn His Lys Glu Glu Met Gln Val Leu Gln Cys Ala
                 220                 225                 230

 gct gga ggc aac gtg aac gtg gag atg aac gca gcc ccc ggg gtg gac      833
 Ala Gly Gly Asn Val Asn Val Glu Met Asn Ala Ala Pro Gly Val Asp
             235                 240                 245

 ctc aca gtt ctg ctg aac aat atg cga gct gag tac gaa gcc ctc gca      881
 Leu Thr Val Leu Leu Asn Asn Met Arg Ala Glu Tyr Glu Ala Leu Ala
         250                 255                 260

 gag cag aac cgc agg gac gcg gag gcc tgg ttc aac gaa aag agc gcc      929
 Glu Gln Asn Arg Arg Asp Ala Glu Ala Trp Phe Asn Glu Lys Ser Ala
     265                 270                 275

 tcg ctg cag cag cag atc tct gac gac gct ggc gcc acc acc tca gcc      977
 Ser Leu Gln Gln Gln Ile Ser Asp Asp Ala Gly Ala Thr Thr Ser Ala
 280                 285                 290                 295

 cgg aat gag ctt acc gag atg aaa cgc act ctt caa acc ctt gag att     1025
 Arg Asn Glu Leu Thr Glu Met Lys Arg Thr Leu Gln Thr Leu Glu Ile
                 300                 305                 310

 gaa ctt cag tcc ctc tta gca acg aaa cac tcc ctg gag tgc tcc ttg     1073
 Glu Leu Gln Ser Leu Leu Ala Thr Lys His Ser Leu Glu Cys Ser Leu
             315                 320                 325

 aca gag acc gag agt aac tac tgt gca cag ctg gca cag atc cag gct     1121
 Thr Glu Thr Glu Ser Asn Tyr Cys Ala Gln Leu Ala Gln Ile Gln Ala
         330                 335                 340

 cag atc ggg gcc ctg gag gag cag ctg cac cag gtc aga acc gag acc     1169
 Gln Ile Gly Ala Leu Glu Glu Gln Leu His Gln Val Arg Thr Glu Thr
     345                 350                 355

 gag ggc cag aag ctc gag tat gag cag ctc ctt gac atc aag gtc cac     1217
 Glu Gly Gln Lys Leu Glu Tyr Glu Gln Leu Leu Asp Ile Lys Val His
 360                 365                 370                 375

 ctg gaa aaa gaa att gag acc tac tgc ctc ctg ata gat gga gaa gat     1265
 Leu Glu Lys Glu Ile Glu Thr Tyr Cys Leu Leu Ile Asp Gly Glu Asp
                 380                 385                 390

 ggc tcc tgt tct aaa tca aaa ggc tat gga ggc cca gga aat caa aca     1313
 Gly Ser Cys Ser Lys Ser Lys Gly Tyr Gly Gly Pro Gly Asn Gln Thr
             395                 400                 405

 aaa gat tca tct aaa acc acc att gtc aaa aca gtt gtt gaa gag ata     1361
 Lys Asp Ser Ser Lys Thr Thr Ile Val Lys Thr Val Val Glu Glu Ile
         410                 415                 420

 gat cct cgt ggc aaa gtt ctc tca tcc aga gtt cac act gtg gaa gag     1409
 Asp Pro Arg Gly Lys Val Leu Ser Ser Arg Val His Thr Val Glu Glu
     425                 430                 435

 aaa tcc acc aaa gtc aac aac aag aat gaa cag agg gtg tct tcc tga     1457
 Lys Ser Thr Lys Val Asn Asn Lys Asn Glu Gln Arg Val Ser Ser 
 440                 445                 450

 actccagcct ctgagacaga atggcccccc aaattaaatt accaaaatga agct         1511




      <210> 490
      <211> 784
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (71)..(784)

      <400> 490
 acagacatgg ttccagctct gtagaactga gagaaagaat aaacaagtca cacattagcc     60

 cttcaaaaag   atg acc gac ctc ttg aga agt gtt gtc acc gta att gat     109
              Met Thr Asp Leu Leu Arg Ser Val Val Thr Val Ile Asp
                1               5                  10

 gtt ttc tac aaa tac acc aag caa gat ggg gag tgt ggc aca ctg agc      157
 Val Phe Tyr Lys Tyr Thr Lys Gln Asp Gly Glu Cys Gly Thr Leu Ser
      15                  20                  25

 aag ggt gaa cta aag gaa ctt ctg gag aaa gag ctt cat cca gtt ctg      205
 Lys Gly Glu Leu Lys Glu Leu Leu Glu Lys Glu Leu His Pro Val Leu
  30                  35                  40                  45

 aag aac cca gat gat cca gac aca gtg gat gtc atc atg cat atg ctg      253
 Lys Asn Pro Asp Asp Pro Asp Thr Val Asp Val Ile Met His Met Leu
                  50                  55                  60

 gat cga gat cat gac aga aga ttg gac ttt act gag ttt ctt ttg atg      301
 Asp Arg Asp His Asp Arg Arg Leu Asp Phe Thr Glu Phe Leu Leu Met
              65                  70                  75

 ata ttc aag ctg act atg gcc tgc aac aag gtc ctc agc aaa gaa tac      349
 Ile Phe Lys Leu Thr Met Ala Cys Asn Lys Val Leu Ser Lys Glu Tyr
          80                  85                  90

 tgc aaa gct tca ggg tca aag aag cat agg cgt ggt cac cga cac caa      397
 Cys Lys Ala Ser Gly Ser Lys Lys His Arg Arg Gly His Arg His Gln
      95                 100                 105

 gaa gaa gaa agt gaa aca gaa gag gat gaa gag gat aca cca gga cat      445
 Glu Glu Glu Ser Glu Thr Glu Glu Asp Glu Glu Asp Thr Pro Gly His
 110                 115                 120                 125

 aaa tca ggt tac aga cat tca agt tgg agt gag gga gag gag cat gga      493
 Lys Ser Gly Tyr Arg His Ser Ser Trp Ser Glu Gly Glu Glu His Gly
                 130                 135                 140

 tat agt tct ggg cac tca agg gga act gtg aaa tgt aga cat ggg tcc      541
 Tyr Ser Ser Gly His Ser Arg Gly Thr Val Lys Cys Arg His Gly Ser
             145                 150                 155

 aac tcc agg agg cta gga aga caa ggt aat tta tcc agc tct ggg aac      589
 Asn Ser Arg Arg Leu Gly Arg Gln Gly Asn Leu Ser Ser Ser Gly Asn
         160                 165                 170

 caa gag gga tct cag aaa aga tac cac agg tcc agc tgt ggt cat tca      637
 Gln Glu Gly Ser Gln Lys Arg Tyr His Arg Ser Ser Cys Gly His Ser
     175                 180                 185

 tgg agt ggt ggc aaa gac aga cat ggt tcc agc tct gta gaa ctg aga      685
 Trp Ser Gly Gly Lys Asp Arg His Gly Ser Ser Ser Val Glu Leu Arg
 190                 195                 200                 205

 gaa aga ata aac aag tca cac att agc cct tct agg gaa tct ggg gag      733
 Glu Arg Ile Asn Lys Ser His Ile Ser Pro Ser Arg Glu Ser Gly Glu
                 210                 215                 220

 gag tat gaa tct gga tct gga tca aac agt tgg gaa agg aaa ggt cat      781
 Glu Tyr Glu Ser Gly Ser Gly Ser Asn Ser Trp Glu Arg Lys Gly His
             225                 230                 235

 ggt                                                                  784
 Gly 






      <210> 491
      <211> 2424
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (138)..(2138)

      <400> 491
 tttcgtcgag ttttgctgac cttggtgggc agaggaaaga agagcctctg gctgccaagg     60

 aggccctcgg ccacctgtcc ctcgctgagg tgggcacaga ggagttcctg cagaaactga    120

 cctcccagat cactgag   atg gta tcg gcc aag atc acg cag gcc aag ctg     170
                      Met Val Ser Ala Lys Ile Thr Gln Ala Lys Leu
                        1               5                  10

 cag gtg cca gga ggt gac agt gat gag gac tcc aag aca cca tct gca      218
 Gln Val Pro Gly Gly Asp Ser Asp Glu Asp Ser Lys Thr Pro Ser Ala
              15                  20                  25

 tcc ccc cgc cat ggc cga tca cgg cca tcc tcc agc att cag gag tct      266
 Ser Pro Arg His Gly Arg Ser Arg Pro Ser Ser Ser Ile Gln Glu Ser
          30                  35                  40

 tcc tca gag tca gag gac ggc gat gcc cga ggc gag atc ttt gac atc      314
 Ser Ser Glu Ser Glu Asp Gly Asp Ala Arg Gly Glu Ile Phe Asp Ile
      45                  50                  55

 tac gtg gtc acc gct gac tac ctg ccc cta ggg gct gag cag gat gcc      362
 Tyr Val Val Thr Ala Asp Tyr Leu Pro Leu Gly Ala Glu Gln Asp Ala
  60                  65                  70                  75

 atc acg ctg cgg gaa ggc cag tat gtg gag gtc ctg gat gca gcc cac      410
 Ile Thr Leu Arg Glu Gly Gln Tyr Val Glu Val Leu Asp Ala Ala His
                  80                  85                  90

 cca ctg cgc tgg ctt gtc cgc acc aag ccc acc aag tcc agc ccc tca      458
 Pro Leu Arg Trp Leu Val Arg Thr Lys Pro Thr Lys Ser Ser Pro Ser
              95                 100                 105

 cgg cag ggc tgg gtg tca cca gcc tac ctg gac agg agg ctc aag ctg      506
 Arg Gln Gly Trp Val Ser Pro Ala Tyr Leu Asp Arg Arg Leu Lys Leu
         110                 115                 120

 tca cct gag tgg ggg gcc gct gag gcc cct gag ttc cct ggg gag gct      554
 Ser Pro Glu Trp Gly Ala Ala Glu Ala Pro Glu Phe Pro Gly Glu Ala
     125                 130                 135

 gtg tct gaa gac gaa tac aag gca agg ctg agc tct gtg atc cag gag      602
 Val Ser Glu Asp Glu Tyr Lys Ala Arg Leu Ser Ser Val Ile Gln Glu
 140                 145                 150                 155

 ctg ctg agt tct gag cag gcc ttc gtg gag gag ctg cag ttc ctg cag      650
 Leu Leu Ser Ser Glu Gln Ala Phe Val Glu Glu Leu Gln Phe Leu Gln
                 160                 165                 170

 agc cac cac ctg cag cac ctg gag cgc tgc ccc cac gtg ccc ata gcc      698
 Ser His His Leu Gln His Leu Glu Arg Cys Pro His Val Pro Ile Ala
             175                 180                 185

 gtg gcc ggc cag aag gca gtc atc ttc cgc aat gtg cgg gac atc ggc      746
 Val Ala Gly Gln Lys Ala Val Ile Phe Arg Asn Val Arg Asp Ile Gly
         190                 195                 200

 cgc ttc cac agc agc ttc ctg cag gag ttg cag cag tgc gac acg gac      794
 Arg Phe His Ser Ser Phe Leu Gln Glu Leu Gln Gln Cys Asp Thr Asp
     205                 210                 215

 gac gac gtg gcc atg tgc ttc atc aag aac cag gcg gcc ttt gag cag      842
 Asp Asp Val Ala Met Cys Phe Ile Lys Asn Gln Ala Ala Phe Glu Gln
 220                 225                 230                 235

 tac ctg gag ttc ctg gtg ggg cgt gtg cag gct gag tcg gtg gtc gtc      890
 Tyr Leu Glu Phe Leu Val Gly Arg Val Gln Ala Glu Ser Val Val Val
                 240                 245                 250

 agc acg gcc atc cag gag ttc tac aag aaa tac gcg gag gag gcc ctg      938
 Ser Thr Ala Ile Gln Glu Phe Tyr Lys Lys Tyr Ala Glu Glu Ala Leu
             255                 260                 265

 ttg gca ggg gac ccc tct cag ccc ccg cca cca cct ctg cag cac tac      986
 Leu Ala Gly Asp Pro Ser Gln Pro Pro Pro Pro Pro Leu Gln His Tyr
         270                 275                 280

 ctg gag cag cca gtg gag cgg gtg cag cgc tac cag gcc ttg ctg aag     1034
 Leu Glu Gln Pro Val Glu Arg Val Gln Arg Tyr Gln Ala Leu Leu Lys
     285                 290                 295

 gag ctg atc cgc aac aag gcg cgg aac aga cag aac tgc gcg ctg ctg     1082
 Glu Leu Ile Arg Asn Lys Ala Arg Asn Arg Gln Asn Cys Ala Leu Leu
 300                 305                 310                 315

 gag cag gcc tat gcc gtg gtg tct gcc ctg cca cag cgc gct gag aac     1130
 Glu Gln Ala Tyr Ala Val Val Ser Ala Leu Pro Gln Arg Ala Glu Asn
                 320                 325                 330

 aag ctg cac gtg tcc ctc atg gag aac tac cca ggc acc ctg gag gcc     1178
 Lys Leu His Val Ser Leu Met Glu Asn Tyr Pro Gly Thr Leu Glu Ala
             335                 340                 345

 ctg ggc gag ccc atc cgc cag ggc cac ttc atc gtg tgg gag ggt gca     1226
 Leu Gly Glu Pro Ile Arg Gln Gly His Phe Ile Val Trp Glu Gly Ala
         350                 355                 360

 ccg ggg gcc cgc atg ccc tgg aag ggc cac aac cgt cac gtg ttc ctc     1274
 Pro Gly Ala Arg Met Pro Trp Lys Gly His Asn Arg His Val Phe Leu
     365                 370                 375

 ttc cgc aac cac ctg gta atc tgc aag ccc cgg cga gac tcc cgc acc     1322
 Phe Arg Asn His Leu Val Ile Cys Lys Pro Arg Arg Asp Ser Arg Thr
 380                 385                 390                 395

 gat acc gtc agc tac gtg ttc cgg aac atg atg aag ctg agc agc atc     1370
 Asp Thr Val Ser Tyr Val Phe Arg Asn Met Met Lys Leu Ser Ser Ile
                 400                 405                 410

 gac ctg aac gac cag gtg gag ggg gat gac cgc gcc ttc gag gtg tgg     1418
 Asp Leu Asn Asp Gln Val Glu Gly Asp Asp Arg Ala Phe Glu Val Trp
             415                 420                 425

 cag gag cgg gag gac tcg gtg cgc aag tac ctg ctg cag gca cgg aca     1466
 Gln Glu Arg Glu Asp Ser Val Arg Lys Tyr Leu Leu Gln Ala Arg Thr
         430                 435                 440

 gcc att atc aag agc tcg tgg gtg aag gag atc tgt ggc atc cag cag     1514
 Ala Ile Ile Lys Ser Ser Trp Val Lys Glu Ile Cys Gly Ile Gln Gln
     445                 450                 455

 cgt ctg gcc ctg cct gtg tgg cgg ccc ccg gac ttt gaa gag gag ctg     1562
 Arg Leu Ala Leu Pro Val Trp Arg Pro Pro Asp Phe Glu Glu Glu Leu
 460                 465                 470                 475

 gcc gac tgc aca gcc gag ctg ggt gag aca gtc aag ctg gcc tgc cgc     1610
 Ala Asp Cys Thr Ala Glu Leu Gly Glu Thr Val Lys Leu Ala Cys Arg
                 480                 485                 490

 gtg acg ggc aca ccc aag cct gtc atc agc tgg tac aaa gat ggg aaa     1658
 Val Thr Gly Thr Pro Lys Pro Val Ile Ser Trp Tyr Lys Asp Gly Lys
             495                 500                 505

 gca gtg cag gtg gac ccc cac cac atc ctc att gaa gac cct gat ggc     1706
 Ala Val Gln Val Asp Pro His His Ile Leu Ile Glu Asp Pro Asp Gly
         510                 515                 520

 tcg tgt gca ctc atc ctg gac agc ctg acc ggt gtg gac tct ggc cag     1754
 Ser Cys Ala Leu Ile Leu Asp Ser Leu Thr Gly Val Asp Ser Gly Gln
     525                 530                 535

 tac atg tgc ttc gcg gcc agc gcc gct ggc aac tgc agt acc ctg ggc     1802
 Tyr Met Cys Phe Ala Ala Ser Ala Ala Gly Asn Cys Ser Thr Leu Gly
 540                 545                 550                 555

 aag atc ctg gtg caa gtc cca cca cgg ttc gtg aac aag gtc cgg gcc     1850
 Lys Ile Leu Val Gln Val Pro Pro Arg Phe Val Asn Lys Val Arg Ala
                 560                 565                 570

 tca ccc ttt gtg gag gga gag gac gcc cag ttc acc tgc acc atc gaa     1898
 Ser Pro Phe Val Glu Gly Glu Asp Ala Gln Phe Thr Cys Thr Ile Glu
             575                 580                 585

 ggc gcc ccg tac ccg cag acc agg tgg tac aag gac ggg gcc ctg ctg     1946
 Gly Ala Pro Tyr Pro Gln Thr Arg Trp Tyr Lys Asp Gly Ala Leu Leu
         590                 595                 600

 acc act ggc aac aag ttc cag aca ctg agt gag cct cgc agc ggc ctg     1994
 Thr Thr Gly Asn Lys Phe Gln Thr Leu Ser Glu Pro Arg Ser Gly Leu
     605                 610                 615

 cta gtg ctg gtg atc cgg gcg gcc agc aag gag gac ctg ggg ctc tac     2042
 Leu Val Leu Val Ile Arg Ala Ala Ser Lys Glu Asp Leu Gly Leu Tyr
 620                 625                 630                 635

 gag tgt gag gtg agg agt gca gga gtg ggg acc ggc ctc ggg acc cag     2090
 Glu Cys Glu Val Arg Ser Ala Gly Val Gly Thr Gly Leu Gly Thr Gln
                 640                 645                 650

 gcc atc ctt gct ggc cat cct ctg ggg tct gat tgt gga ggg gct taa     2138
 Ala Ile Leu Ala Gly His Pro Leu Gly Ser Asp Cys Gly Gly Ala 
             655                 660                 665

 gagcccggtc cctgtcctca aggtaggggg ctctcggcag aggccagggg acaccatacc   2198

 cactgctaca cccttgatga caggccagag gccaccatgc cactgtcacc cccccatcac   2258

 aggccggggg ccaccaggcc actgtcaccc cccatcacag gccgggggcc accatgccac   2318

 tgtcactgtc atccctggcc acaccactgg cccatgccct ggcctcattc ttcctctgcc   2378

 tctaagcctc ttctctgctc ccatgtcaat ctggatgcct tccttg                  2424




      <210> 492
      <211> 3201
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (151)..(1482)

      <400> 492
 ggaattcgcc gtggcgcgaa cttgggactg cagaggcgcg cctggcggat ctgagtgtgt     60

 tgcccgggca gcggcgcgcg ggaccaacgc aaggagcagc tgacagacga agaaaagtgc    120

 tggacaggaa gggagaattc tgacgccaac     atg cag cga agt atc atg tca     171
                                      Met Gln Arg Ser Ile Met Ser
                                        1               5

 ttt ttc cac ccc aag aaa gag ggt aaa gca aag aag cct gag aag gag      219
 Phe Phe His Pro Lys Lys Glu Gly Lys Ala Lys Lys Pro Glu Lys Glu
          10                  15                  20

 gca tcc aat agc agc aga gag acg gag ccc cct cca aag gcg gca ctg      267
 Ala Ser Asn Ser Ser Arg Glu Thr Glu Pro Pro Pro Lys Ala Ala Leu
      25                  30                  35

 aag gag tgg aat gga gtg gtg tcc gag agt gac tct ccg gtg aag agg      315
 Lys Glu Trp Asn Gly Val Val Ser Glu Ser Asp Ser Pro Val Lys Arg
  40                  45                  50                  55

 cca ggg agg aag gcg gcc cgg gtc ctg ggc agc gaa ggg gaa gag gag      363
 Pro Gly Arg Lys Ala Ala Arg Val Leu Gly Ser Glu Gly Glu Glu Glu
                  60                  65                  70

 gat gaa gcc ctt agc cct gct aaa ggc cag aag cct gcc ctg gac tgc      411
 Asp Glu Ala Leu Ser Pro Ala Lys Gly Gln Lys Pro Ala Leu Asp Cys
              75                  80                  85

 tca cag gtc tcc ccg ccc cgt cct gcc aca tct cct gag aac aat gct      459
 Ser Gln Val Ser Pro Pro Arg Pro Ala Thr Ser Pro Glu Asn Asn Ala
          90                  95                 100

 tcc ctc tct gac acc tct ccc atg gac agt tcc cca tca ggg att ccg      507
 Ser Leu Ser Asp Thr Ser Pro Met Asp Ser Ser Pro Ser Gly Ile Pro
     105                 110                 115

 aag cgt cgc aca gct cgg aag cag ctc ccg aaa cgg acc att cag gaa      555
 Lys Arg Arg Thr Ala Arg Lys Gln Leu Pro Lys Arg Thr Ile Gln Glu
 120                 125                 130                 135

 gtc ctg gaa gag cag agt gag gac gag gac aga gaa gcc aag agg aag      603
 Val Leu Glu Glu Gln Ser Glu Asp Glu Asp Arg Glu Ala Lys Arg Lys
                 140                 145                 150

 aag gag gag gaa gaa gag gag acc ccg aaa gaa agc ctc aca gag gct      651
 Lys Glu Glu Glu Glu Glu Glu Thr Pro Lys Glu Ser Leu Thr Glu Ala
             155                 160                 165

 gaa gtg gcc aca gag aag gaa gga gaa gac ggg gac cag ccc acc acg      699
 Glu Val Ala Thr Glu Lys Glu Gly Glu Asp Gly Asp Gln Pro Thr Thr
         170                 175                 180

 cct ccc aag ccc cta aag acc tcc aaa gca gag acc ccg acg gaa agc      747
 Pro Pro Lys Pro Leu Lys Thr Ser Lys Ala Glu Thr Pro Thr Glu Ser
     185                 190                 195

 gtt tca gag cct gag gtg gcc acg aag cag gaa ctg cag gag gag gaa      795
 Val Ser Glu Pro Glu Val Ala Thr Lys Gln Glu Leu Gln Glu Glu Glu
 200                 205                 210                 215

 gag cag acc aag cct ccc cgc aga gct ccc aag acg ctc agc agc ttc      843
 Glu Gln Thr Lys Pro Pro Arg Arg Ala Pro Lys Thr Leu Ser Ser Phe
                 220                 225                 230

 ttc acc ccc cgg aag cca gca gtc aaa aaa gaa gtg aag gaa gag gag      891
 Phe Thr Pro Arg Lys Pro Ala Val Lys Lys Glu Val Lys Glu Glu Glu
             235                 240                 245

 cca ggg gct cca gga aag gag gga gct gct gag gga ccc ctg gat cca      939
 Pro Gly Ala Pro Gly Lys Glu Gly Ala Ala Glu Gly Pro Leu Asp Pro
         250                 255                 260

 tct ggt tac aat cct gcc aag aac aac tat cat ccc gtg gaa gat gcc      987
 Ser Gly Tyr Asn Pro Ala Lys Asn Asn Tyr His Pro Val Glu Asp Ala
     265                 270                 275

 tgc tgg aaa ccg ggc cag aag gtt cct tac ctg gct gtg gcc cgg acg     1035
 Cys Trp Lys Pro Gly Gln Lys Val Pro Tyr Leu Ala Val Ala Arg Thr
 280                 285                 290                 295

 ttt gag aag atc gag gag gtg tct gct cgg ctc cgg atg gtg gag acg     1083
 Phe Glu Lys Ile Glu Glu Val Ser Ala Arg Leu Arg Met Val Glu Thr
                 300                 305                 310

 ctg agc aac ttg ctg cgc tcc gtg gtg gcc ctg tcg cct cca gac ctc     1131
 Leu Ser Asn Leu Leu Arg Ser Val Val Ala Leu Ser Pro Pro Asp Leu
             315                 320                 325

 ctc cct gtc ctc tac ctc agc ctc aac cac ctt ggg cca ccc cag cag     1179
 Leu Pro Val Leu Tyr Leu Ser Leu Asn His Leu Gly Pro Pro Gln Gln
         330                 335                 340

 ggc ctg gag ctt ggc gtg ggt gat ggt gtc ctt ctc aag gca gtg gcc     1227
 Gly Leu Glu Leu Gly Val Gly Asp Gly Val Leu Leu Lys Ala Val Ala
     345                 350                 355

 cag gcc aca ggt cgg cag ctg gag tcc gtc cgg gct gag gca gcc gag     1275
 Gln Ala Thr Gly Arg Gln Leu Glu Ser Val Arg Ala Glu Ala Ala Glu
 360                 365                 370                 375

 aaa ggc gac gtg ggg ctg gtg gcc gag aac agc cgc agg cac cca gag     1323
 Lys Gly Asp Val Gly Leu Val Ala Glu Asn Ser Arg Arg His Pro Glu
                 380                 385                 390

 gct cat gct gcc acc acc tcc gct cac tgc ctc cgg ggt ctt cag caa     1371
 Ala His Ala Ala Thr Thr Ser Ala His Cys Leu Arg Gly Leu Gln Gln
             395                 400                 405

 gtt ccg cga cat cgc cag gct cac tgg cag tgc ttc cac agc caa gaa     1419
 Val Pro Arg His Arg Gln Ala His Trp Gln Cys Phe His Ser Gln Glu
         410                 415                 420

 gat aga cat cat caa agg cct ctt tgt ggc ctg ccg cca ctc aga agc     1467
 Asp Arg His His Gln Arg Pro Leu Cys Gly Leu Pro Pro Leu Arg Ser
     425                 430                 435

 ccg gtt cat cgc tag gtccctgagc ggacggctgc gccttgggct ggcagagcag     1522
 Pro Val His Arg 
 440

 tcggtgctgg ctgccctctc ccaggcagtg agcctcacgc ccccgggcca agaattccca   1582

 ccagccatgg tggatgctgg gaagggcaag acagcagagg ccagaaagac gtggctggag   1642

 gagcaaggca tgatcctgaa gcagacgttc tgcgaggttc ccgacctgga ccgaattatc   1702

 cccgtgctgc tggagcacgg cctggaacgt ctcccggagc actgcaagct gagcccaggg   1762

 attcccctga aaccaatgtt ggcccatccc acccggggca tcagcgaggt cctgaaacgc   1822

 tttgaggagg cagctttcac ctgcgaatac aaatatgacg ggcagagggc acagatccac   1882

 gccctggaag gcggggaggt gaagatcttc agcaggaatc aggaagacaa cactgggaag   1942

 tacccggaca tcatcagccg catccccaag attaaactcc catcggtcac atccttcatc   2002

 ctggacaccg aagccgtggc ttgggaccgg gaaaagaagc agatccagcc attccaagtg   2062

 ctcaccaccc gcaaacgcaa ggaggtggat gcgtctgaga tccaggtgca ggtgtgtttg   2122

 tacgccttcg acctcatcta cctcaatgga gagtccctgg tacgtgagcc cctttcccgg   2182

 cgccggcagc tgctccggga gaactttgtg gagacagagg gcgagtttgt cttcgccacc   2242

 tccctggaca ccaaggacat cgagcagatc gccgagttcc tggagcagtc agtgaaagac   2302

 tcctgcgagg ggctgatggt gaagaccctg gatgttgatg ccacctacga gatcgccaag   2362

 agatcgcaca actggctcaa gctgaagaag gactaccttg atggcgtggg tgacaccctg   2422

 gacctggtgg tgatcggcgc ctacctgggc cgggggaagc gggccggccg gtacgggggc   2482

 ttcctgctgg cctcctacga cgaggacagt gaggagctgc aggccatatg caagcttgga   2542

 actggcttca gtgatgagga gctggaggag catcaccaga gcctcaaggc gctggtgctg   2602

 cccagcccac gcccttacgt gcggatagat ggcgctgtga ttcccgacca ctggctggac   2662

 cccagcgctg tgtgggaggt gaagtgcgct gacctctccc tctctcccat ctaccctgct   2722

 gcgcggggcc tggtggatag tgacaagggc atctcccttc gcttccctcg gtttattcga   2782

 gtccgtgaag acaagcagcc ggagcaggcc accaccagtg ctcaggtggc ctgtttgtac   2842

 cggaagcaaa gtcagattca gaaccaacaa ggcgaggact caggctctga ccctgaagat   2902

 acctactaag ccctcgccct cctagggcct gggtacaggg catgagttgg acggacccca   2962

 gggttattat tgcctttgct ttttagcaaa tctgctgtgg caggctgtgg attttgagag   3022

 tcaggggagg ggtgtgtgtg tgagggggtg gcttactccg gagtctggga ttcatcccgt   3082

 catttctttc aataaataat tattggataa aaaaaaaaaa aaaaaaaaga tgcggccgct   3142

 ctagagtatc cctcgagggg cccaagctta cgcgtaccca gctttcttgt acaaagtgg    3201




      <210> 493
      <211> 574
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (97)..(420)

      <400> 493
 acacagctgg aacttctccc acggaagctc agtgtgggtg catctgtaga caacctttcc     60

 agaacacttc aaggtaattg catccccaca ggaaaa  atg cct tcc agg ttt agt     114
                                          Met Pro Ser Arg Phe Ser
                                            1               5

 ctt aca caa ggg gga gag tca caa tcc ctg tct aca tgg aac atc agc      162
 Leu Thr Gln Gly Gly Glu Ser Gln Ser Leu Ser Thr Trp Asn Ile Ser
              10                  15                  20

 act cat gca ggg ttg agt gga gaa gac cag gtg acg cag agt ccc gag      210
 Thr His Ala Gly Leu Ser Gly Glu Asp Gln Val Thr Gln Ser Pro Glu
          25                  30                  35

 gcc ctg aga ctc cag gag gga gag agt agc agt ctc aac tgc agt tac      258
 Ala Leu Arg Leu Gln Glu Gly Glu Ser Ser Ser Leu Asn Cys Ser Tyr
      40                  45                  50

 aca gtc agc ggt tta aga ggg ctg ttc tgg tat agg caa gat cct ggg      306
 Thr Val Ser Gly Leu Arg Gly Leu Phe Trp Tyr Arg Gln Asp Pro Gly
  55                  60                  65                  70

 aaa ggc cct gaa ttc ctc ttc acc ctg tat tca gct ggg gaa gaa aag      354
 Lys Gly Pro Glu Phe Leu Phe Thr Leu Tyr Ser Ala Gly Glu Glu Lys
                  75                  80                  85

 gag aaa gaa agg cta aaa gcc aca tta aca aag aag gaa agc ttt ctg      402
 Glu Lys Glu Arg Leu Lys Ala Thr Leu Thr Lys Lys Glu Ser Phe Leu
              90                  95                 100

 gca cat cac agc ccc taa acctga agactcagcc acttatctct gtgctgtgag      456
 Ala His His Ser Pro 
         105

 gcgatcagat ggccagaagc tgctctttgc aaggggaacc atgttaaagg tggatcttaa    516

 tatccagaac cctgaccctg ccgtgtacca gctgagagac tctaaatcca gtgacaag      574




      <210> 494
      <211> 1381
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (146)..(1327)

      <400> 494
 ctagtccagt gcggtggaat tcggaagctt actccttgga aacatcaaag gcttgggaag     60

 gtgaattccg aatatagagt caaaatttct gagcccagct cagtatttat ataaagctgg    120

 ggcttggaca catgtaaagg gaaac  atg cca aat cag ggt tct cta aat gcc     172
                              Met Pro Asn Gln Gly Ser Leu Asn Ala
                                1               5

 atg tgg tat gct gag gtt aaa gaa ctc cga gaa aag gct gag ttt tat      220
 Met Trp Tyr Ala Glu Val Lys Glu Leu Arg Glu Lys Ala Glu Phe Tyr
  10                  15                  20                  25

 agg aag cga gtt cag ggg acg cat ttt tct cgg gac cat ctg aat cag      268
 Arg Lys Arg Val Gln Gly Thr His Phe Ser Arg Asp His Leu Asn Gln
                  30                  35                  40

 att tta tct gat agc aac tgc tgt tgg gat gtc tcc tca acc aca agc      316
 Ile Leu Ser Asp Ser Asn Cys Cys Trp Asp Val Ser Ser Thr Thr Ser
              45                  50                  55

 tca gaa gga acc gtt agt agc aac atc aga gca tta gat ctt gct gga      364
 Ser Glu Gly Thr Val Ser Ser Asn Ile Arg Ala Leu Asp Leu Ala Gly
          60                  65                  70

 gat cct aca agc cat aag act ttg cag aaa tgt cct tct aca gaa cca      412
 Asp Pro Thr Ser His Lys Thr Leu Gln Lys Cys Pro Ser Thr Glu Pro
      75                  80                  85

 gaa gaa aaa gga aat atc gtg gaa gaa cag ccc cag aaa aat acc acg      460
 Glu Glu Lys Gly Asn Ile Val Glu Glu Gln Pro Gln Lys Asn Thr Thr
  90                  95                 100                 105

 gag aaa ttg ggt gtg tca gct ccc acc ata ccc gtt aga agg cgg ctg      508
 Glu Lys Leu Gly Val Ser Ala Pro Thr Ile Pro Val Arg Arg Arg Leu
                 110                 115                 120

 gct tgg gat aca gag aac aca agt gaa gac gta cag aaa cag ccc ggg      556
 Ala Trp Asp Thr Glu Asn Thr Ser Glu Asp Val Gln Lys Gln Pro Gly
             125                 130                 135

 gag aaa gag gag gag gac gac aat gaa gag gaa ggg gac agg aaa acg      604
 Glu Lys Glu Glu Glu Asp Asp Asn Glu Glu Glu Gly Asp Arg Lys Thr
         140                 145                 150

 ggc aag cag gct ttt atg gga gag caa gag aag ttg gat gta cat gag      652
 Gly Lys Gln Ala Phe Met Gly Glu Gln Glu Lys Leu Asp Val His Glu
     155                 160                 165

 aaa tct aag gca gat aag atg aaa gaa ggg tca gat tct tct gta tcc      700
 Lys Ser Lys Ala Asp Lys Met Lys Glu Gly Ser Asp Ser Ser Val Ser
 170                 175                 180                 185

 tca gaa aaa gga ggc cgg ctt cct act ccc aag ctg aga gaa ctt ggt      748
 Ser Glu Lys Gly Gly Arg Leu Pro Thr Pro Lys Leu Arg Glu Leu Gly
                 190                 195                 200

 gga atc cag agg act cat cat gat ctc act act cca gct gtt ggt ggt      796
 Gly Ile Gln Arg Thr His His Asp Leu Thr Thr Pro Ala Val Gly Gly
             205                 210                 215

 gct gtt tta gtg tct cca tct aag atg aag cct cca gcc cca gaa cag      844
 Ala Val Leu Val Ser Pro Ser Lys Met Lys Pro Pro Ala Pro Glu Gln
         220                 225                 230

 agg aaa aga atg acc tct cag gat tgt tta gaa act tca aag aat gat      892
 Arg Lys Arg Met Thr Ser Gln Asp Cys Leu Glu Thr Ser Lys Asn Asp
     235                 240                 245

 ttt act aag aaa gaa agt cgt gct gta tcc cta ctg act tct cca gct      940
 Phe Thr Lys Lys Glu Ser Arg Ala Val Ser Leu Leu Thr Ser Pro Ala
 250                 255                 260                 265

 gct ggt ata aaa aca gtt gat cct ctg cct ttg cgg gaa gat tct gaa      988
 Ala Gly Ile Lys Thr Val Asp Pro Leu Pro Leu Arg Glu Asp Ser Glu
                 270                 275                 280

 gac aat atc cac aaa ttt gct gag gca act ctt cca gtt tca aaa att     1036
 Asp Asn Ile His Lys Phe Ala Glu Ala Thr Leu Pro Val Ser Lys Ile
             285                 290                 295

 cca aaa tac cca aca aat ccc cct gga cag ttg cct tct cca cca cat     1084
 Pro Lys Tyr Pro Thr Asn Pro Pro Gly Gln Leu Pro Ser Pro Pro His
         300                 305                 310

 gtt cca tcc tac tgg cat ccc tct cga cga att cag ggc tct ctt aga     1132
 Val Pro Ser Tyr Trp His Pro Ser Arg Arg Ile Gln Gly Ser Leu Arg
     315                 320                 325

 gat cca gag ttt cag cac aat gtg gga aaa gca agg atg aac aat ttg     1180
 Asp Pro Glu Phe Gln His Asn Val Gly Lys Ala Arg Met Asn Asn Leu
 330                 335                 340                 345

 cag tta cct caa cat gaa gcc ttt aat gat gaa gat gag gac aga ttg     1228
 Gln Leu Pro Gln His Glu Ala Phe Asn Asp Glu Asp Glu Asp Arg Leu
                 350                 355                 360

 tct gag att tct gct cgc tct gca gct tct agt ctc cgg gct ttt caa     1276
 Ser Glu Ile Ser Ala Arg Ser Ala Ala Ser Ser Leu Arg Ala Phe Gln
             365                 370                 375

 act ctg gca cga gct aag aaa agg aag gag aat ttc tgg ggt aaa aca     1324
 Thr Leu Ala Arg Ala Lys Lys Arg Lys Glu Asn Phe Trp Gly Lys Thr
         380                 385                 390

 taa acct agctgagttg cctttatcta aggaaacatt ggcataattt ttctttattg     1381
 






      <210> 495
      <211> 450
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (65)..(244)

      <400> 495
 cctgggttca tcctaatcaa gctgaacatt agtcactggg ttccacggtt ctcttccatg     60

 accc atg gct tct aat aga gct ata aca ctc acc gca tgg ccc aag att     109
      Met Ala Ser Asn Arg Ala Ile Thr Leu Thr Ala Trp Pro Lys Ile
        1               5                  10                  15

 cca ttc ctt gga atc tgt gag gcc aag aac ccc agg tca gag aac atg      157
 Pro Phe Leu Gly Ile Cys Glu Ala Lys Asn Pro Arg Ser Glu Asn Met
                  20                  25                  30

 agg ctt gcc acc att ttg gaa gtg gcc tgc cac cat ctt ggg agc tct      205
 Arg Leu Ala Thr Ile Leu Glu Val Ala Cys His His Leu Gly Ser Ser
              35                  40                  45

 ggg agc aag gac ccc ctg gta aca gta gta gat aca tag aatttttaaa       254
 Gly Ser Lys Asp Pro Leu Val Thr Val Val Asp Thr 
          50                  55

 taaacatact tatattaagg gtactcttag ggtctatact aagaaatttt gcatgcttgt    314

 cattaaaagc tttgagtcca agtcctgtgt gtgtgtatat gactttgact ctaagtcaag    374

 tgtaaatgta actgtataga tatgccatgt atataatgta aataaaatat atacatatat    434

 ttataaaaaa aaaaaa                                                    450




      <210> 496
      <211> 928
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (40)..(819)

      <400> 496
 agaattcccg gaagtggccg gctgggatca gcctttaag   atg gcg tct cct cag      54
                                              Met Ala Ser Pro Gln
                                                1               5

 ggg ggc cag att gcg atc gcg atg agg ctt cgg aac cag ctc cag tca      102
 Gly Gly Gln Ile Ala Ile Ala Met Arg Leu Arg Asn Gln Leu Gln Ser
                  10                  15                  20

 gtg tac aag atg gac ccg cta cgg aac gag gag gag gtt cga gtg aag      150
 Val Tyr Lys Met Asp Pro Leu Arg Asn Glu Glu Glu Val Arg Val Lys
              25                  30                  35

 atc aaa gac ttg aat gaa cac att gtt tgc tgc cta tgc gcc ggc tac      198
 Ile Lys Asp Leu Asn Glu His Ile Val Cys Cys Leu Cys Ala Gly Tyr
          40                  45                  50

 ttc gtg gat gcc acc acc atc aca gag tgt ctt cat act ttc tgc aag      246
 Phe Val Asp Ala Thr Thr Ile Thr Glu Cys Leu His Thr Phe Cys Lys
      55                  60                  65

 agt tgt att gtg aag tac ctc caa act agc aag tac tgc ccc atg tgc      294
 Ser Cys Ile Val Lys Tyr Leu Gln Thr Ser Lys Tyr Cys Pro Met Cys
  70                  75                  80                  85

 aac att aag atc cac gag aca cag cca ctg ctc aac ctc aaa ctg gac      342
 Asn Ile Lys Ile His Glu Thr Gln Pro Leu Leu Asn Leu Lys Leu Asp
                  90                  95                 100

 cgg gtc atg cag gac atc gtg tat aag ctg gtg cct ggc ttg caa gac      390
 Arg Val Met Gln Asp Ile Val Tyr Lys Leu Val Pro Gly Leu Gln Asp
             105                 110                 115

 agt gaa gag aaa cgg att cgg gaa ttc tac cag tcc cga ggt ttg gac      438
 Ser Glu Glu Lys Arg Ile Arg Glu Phe Tyr Gln Ser Arg Gly Leu Asp
         120                 125                 130

 cgg gtc acc cag ccc act ggg gaa gag cca gca ctg agc aac ctc ggc      486
 Arg Val Thr Gln Pro Thr Gly Glu Glu Pro Ala Leu Ser Asn Leu Gly
     135                 140                 145

 ctc ccc ttc agc agc ttt gac cac tct aaa gcc cac tac tat cgc tat      534
 Leu Pro Phe Ser Ser Phe Asp His Ser Lys Ala His Tyr Tyr Arg Tyr
 150                 155                 160                 165

 gat gag cag ttg aac ctg tgc ctg gag cgg ctg agt tct ggc aaa gac      582
 Asp Glu Gln Leu Asn Leu Cys Leu Glu Arg Leu Ser Ser Gly Lys Asp
                 170                 175                 180

 aag aat aaa agc gtc ctg cag aac aag tat gtc cga tgt tct gtt aga      630
 Lys Asn Lys Ser Val Leu Gln Asn Lys Tyr Val Arg Cys Ser Val Arg
             185                 190                 195

 gct gag gta cgc cat ctc cgg agg gtc ctg tgt cac cgc ttg atg cta      678
 Ala Glu Val Arg His Leu Arg Arg Val Leu Cys His Arg Leu Met Leu
         200                 205                 210

 aac cct cag cat gtg cag ctc ctt ttt gac aat gaa gtt ctc cct gat      726
 Asn Pro Gln His Val Gln Leu Leu Phe Asp Asn Glu Val Leu Pro Asp
     215                 220                 225

 cac atg aca atg aag cag ata tgg ctc tcc cgc tgg ttc ggc aag cca      774
 His Met Thr Met Lys Gln Ile Trp Leu Ser Arg Trp Phe Gly Lys Pro
 230                 235                 240                 245

 tcc cct ttg ctt tta caa tac agt gtg aaa gag aag agg agg tag ggg      822
 Ser Pro Leu Leu Leu Gln Tyr Ser Val Lys Glu Lys Arg Arg 
                 250                 255

 ccaagccccc accccatccc actccccttc cctccccaga tatttatgtg aaatgaactg    882

 cagctttatt ttttgaaata aaaactttta aaaagcaaaa aaaaaa                   928




      <210> 497
      <211> 2368
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (41)..(2314)

      <400> 497
 ggaccccggt gtctggcttc ccccgagccg ggaccccgcg  atg gcc aag cgc agc      55
                                              Met Ala Lys Arg Ser
                                                1               5

 tcg ctg tac atc cgc atc gtg gag ggg aag aac ctt ccc gcc aag gac      103
 Ser Leu Tyr Ile Arg Ile Val Glu Gly Lys Asn Leu Pro Ala Lys Asp
                  10                  15                  20

 atc act ggc agc agc gac ccc tac tgc atc gtg aag gtg gac aat gag      151
 Ile Thr Gly Ser Ser Asp Pro Tyr Cys Ile Val Lys Val Asp Asn Glu
              25                  30                  35

 ccc atc atc agg aca gcc aca gtg tgg aag acc ctg tgc ccc ttc tgg      199
 Pro Ile Ile Arg Thr Ala Thr Val Trp Lys Thr Leu Cys Pro Phe Trp
          40                  45                  50

 ggt gag gag tac caa gtg cac ctg ccg ccc acc ttc cac gct gtg gct      247
 Gly Glu Glu Tyr Gln Val His Leu Pro Pro Thr Phe His Ala Val Ala
      55                  60                  65

 ttc tat gtc atg gat gag gat gcc ctc agc cgg gac gac gtt atc gga      295
 Phe Tyr Val Met Asp Glu Asp Ala Leu Ser Arg Asp Asp Val Ile Gly
  70                  75                  80                  85

 aag gtc tgc ctt aca agg gac acc ata gcc tct cac cct aag ggt ttc      343
 Lys Val Cys Leu Thr Arg Asp Thr Ile Ala Ser His Pro Lys Gly Phe
                  90                  95                 100

 agc ggg tgg gcc cac ctg acg gag gtc gac ccc gac gag gag gtg cag      391
 Ser Gly Trp Ala His Leu Thr Glu Val Asp Pro Asp Glu Glu Val Gln
             105                 110                 115

 ggc gag atc cac ctg cgg ctg gaa gtg tgg cca ggg gcc cgg gcc tgc      439
 Gly Glu Ile His Leu Arg Leu Glu Val Trp Pro Gly Ala Arg Ala Cys
         120                 125                 130

 cgg cta cgc tgc tct gtg ctg gag gcc agg gat ctg gcc cca aag gac      487
 Arg Leu Arg Cys Ser Val Leu Glu Ala Arg Asp Leu Ala Pro Lys Asp
     135                 140                 145

 cgc aat ggc aca tct gac ccc ttc gtc cga gtg cgc tac aag ggc cgg      535
 Arg Asn Gly Thr Ser Asp Pro Phe Val Arg Val Arg Tyr Lys Gly Arg
 150                 155                 160                 165

 aca cgg gag acc tcg atc gtg aag aag tca tgc tac cca cgc tgg aat      583
 Thr Arg Glu Thr Ser Ile Val Lys Lys Ser Cys Tyr Pro Arg Trp Asn
                 170                 175                 180

 gag acg ttt gaa ttt gag ctg cag gag ggg gcc atg gag gcg ctg tgc      631
 Glu Thr Phe Glu Phe Glu Leu Gln Glu Gly Ala Met Glu Ala Leu Cys
             185                 190                 195

 gtg gag gcc tgg gac tgg gac ctt gtc agc cga aac gac ttc ctg ggc      679
 Val Glu Ala Trp Asp Trp Asp Leu Val Ser Arg Asn Asp Phe Leu Gly
         200                 205                 210

 aaa gtg gtg att gat gtc cag aga ctg cgg gtg gtg cag cag gag gag      727
 Lys Val Val Ile Asp Val Gln Arg Leu Arg Val Val Gln Gln Glu Glu
     215                 220                 225

 ggc tgg ttc cgg ctg cag ccc gac cag tcc aag agc cgg cgg cat gac      775
 Gly Trp Phe Arg Leu Gln Pro Asp Gln Ser Lys Ser Arg Arg His Asp
 230                 235                 240                 245

 gag ggc aac ctg ggc tcc ttg cag ctg gag gtg cgg ctg cgg gac gag      823
 Glu Gly Asn Leu Gly Ser Leu Gln Leu Glu Val Arg Leu Arg Asp Glu
                 250                 255                 260

 acg gtg ctg ccc tcc agc tac tac cag cca ctg gtg cac ctg ctg tgc      871
 Thr Val Leu Pro Ser Ser Tyr Tyr Gln Pro Leu Val His Leu Leu Cys
             265                 270                 275

 cac gag gtc aag ctg ggc atg cag ggc cca ggg cag ctg atc cca ctc      919
 His Glu Val Lys Leu Gly Met Gln Gly Pro Gly Gln Leu Ile Pro Leu
         280                 285                 290

 atc gag gag aca acc agc acc gag tgt cgc cag gac gtg gcc acg aac      967
 Ile Glu Glu Thr Thr Ser Thr Glu Cys Arg Gln Asp Val Ala Thr Asn
     295                 300                 305

 ctg ctc aag ctc ttc ctg ggg cag ggg ctg gcc aag gac ttc ctg gac     1015
 Leu Leu Lys Leu Phe Leu Gly Gln Gly Leu Ala Lys Asp Phe Leu Asp
 310                 315                 320                 325

 ctg ctc ttc cag ctg gag ctg agt cgc acc agt gag acc aac acc ctg     1063
 Leu Leu Phe Gln Leu Glu Leu Ser Arg Thr Ser Glu Thr Asn Thr Leu
                 330                 335                 340

 ttc cgg agc aac tct ctg gcc tca aag tcc atg gag tct ttt ctg aag     1111
 Phe Arg Ser Asn Ser Leu Ala Ser Lys Ser Met Glu Ser Phe Leu Lys
             345                 350                 355

 gtg gcc ggg atg cag tac ctg cac ggc gtc ctg ggc ccc atc atc aac     1159
 Val Ala Gly Met Gln Tyr Leu His Gly Val Leu Gly Pro Ile Ile Asn
         360                 365                 370

 aag gtg ttt gag gag aag aag tac gtg gag ctg gac ccc agc aaa gtg     1207
 Lys Val Phe Glu Glu Lys Lys Tyr Val Glu Leu Asp Pro Ser Lys Val
     375                 380                 385

 gaa gtt aag gat gta ggg tgc tcc ggg ctg cac cgc ccg cag acc gag     1255
 Glu Val Lys Asp Val Gly Cys Ser Gly Leu His Arg Pro Gln Thr Glu
 390                 395                 400                 405

 gcc gag gtg ctg gag cag agc gcg cag acg ctg cgc gcc cac ctg ggg     1303
 Ala Glu Val Leu Glu Gln Ser Ala Gln Thr Leu Arg Ala His Leu Gly
                 410                 415                 420

 gcc ctg ctg agc gcg ctc agc cgc tcg gtt cgc gcg tgc ccc gcc gtg     1351
 Ala Leu Leu Ser Ala Leu Ser Arg Ser Val Arg Ala Cys Pro Ala Val
             425                 430                 435

 gtg cgc gcc acc ttc cgc cag ctc ttc cgg cgc gtg cgc gag cgc ttc     1399
 Val Arg Ala Thr Phe Arg Gln Leu Phe Arg Arg Val Arg Glu Arg Phe
         440                 445                 450

 ccc ggc gcc cag cac gag aat gta ccg ttc atc gcc gtc acc agc ttc     1447
 Pro Gly Ala Gln His Glu Asn Val Pro Phe Ile Ala Val Thr Ser Phe
     455                 460                 465

 ctg tgc ctg cgc ttc ttc tct ccc gcc atc atg tcg ccc aag ctc ttc     1495
 Leu Cys Leu Arg Phe Phe Ser Pro Ala Ile Met Ser Pro Lys Leu Phe
 470                 475                 480                 485

 cac ctg cgg gag cgc cac gcg gac gcc cgc acc agc cgc acc ctg ctc     1543
 His Leu Arg Glu Arg His Ala Asp Ala Arg Thr Ser Arg Thr Leu Leu
                 490                 495                 500

 ctg ttg gcc aag gca gtc cag aac gtg ggc aac atg gac acg ccg gct     1591
 Leu Leu Ala Lys Ala Val Gln Asn Val Gly Asn Met Asp Thr Pro Ala
             505                 510                 515

 tcc agg gcc aag gag gct tgg atg gag ccg ctg cag ccc acc gtg cgc     1639
 Ser Arg Ala Lys Glu Ala Trp Met Glu Pro Leu Gln Pro Thr Val Arg
         520                 525                 530

 cag ggc gtg gcg cag ctg aag gac ttc atc acc aag ctc gtg gac atc     1687
 Gln Gly Val Ala Gln Leu Lys Asp Phe Ile Thr Lys Leu Val Asp Ile
     535                 540                 545

 gag gag aag gac gag ctg gac ctg cag cgg acg ctg agt ttg cag gcg     1735
 Glu Glu Lys Asp Glu Leu Asp Leu Gln Arg Thr Leu Ser Leu Gln Ala
 550                 555                 560                 565

 cca cct gtg aag gag ggg cca ctc ttc atc cac agg acc aag ggc aag     1783
 Pro Pro Val Lys Glu Gly Pro Leu Phe Ile His Arg Thr Lys Gly Lys
                 570                 575                 580

 ggc ccc ctc atg tcc tcc tcc ttc aag aag ctc tac ttc tcc ctc act     1831
 Gly Pro Leu Met Ser Ser Ser Phe Lys Lys Leu Tyr Phe Ser Leu Thr
             585                 590                 595

 acc gag gcc ctc agc ttc gcg aag atg ccc agc tcc aag tgt gtg aat     1879
 Thr Glu Ala Leu Ser Phe Ala Lys Met Pro Ser Ser Lys Cys Val Asn
         600                 605                 610

 gag ctt aac cag tgg ctg tct gcg ctg cgg aag gtg agc atc aac aac     1927
 Glu Leu Asn Gln Trp Leu Ser Ala Leu Arg Lys Val Ser Ile Asn Asn
     615                 620                 625

 acc gga ctg ctg ggc tcc tac cac cct ggc gtc ttc cgt ggg gac aag     1975
 Thr Gly Leu Leu Gly Ser Tyr His Pro Gly Val Phe Arg Gly Asp Lys
 630                 635                 640                 645

 tgg agc tgc tgc cac caa aaa gag aag aca ggt cag ggc tgc gat aag     2023
 Trp Ser Cys Cys His Gln Lys Glu Lys Thr Gly Gln Gly Cys Asp Lys
                 650                 655                 660

 acc cgg tca cgg gtg acc ctg cag gag tgg aat gac cct ctt gac cat     2071
 Thr Arg Ser Arg Val Thr Leu Gln Glu Trp Asn Asp Pro Leu Asp His
             665                 670                 675

 gac ctt gag gcc cag ctc atc tac cgg cac ctg ctg ggc gtg gag gcc     2119
 Asp Leu Glu Ala Gln Leu Ile Tyr Arg His Leu Leu Gly Val Glu Ala
         680                 685                 690

 atg ctg tgg gag agg cac cgg gag ctg agc ggg ggc aca gag gca ggc     2167
 Met Leu Trp Glu Arg His Arg Glu Leu Ser Gly Gly Thr Glu Ala Gly
     695                 700                 705

 acg gtg ccc acg agc cct ggc aaa gtc ccc gag gac tca ttg gcc cgg     2215
 Thr Val Pro Thr Ser Pro Gly Lys Val Pro Glu Asp Ser Leu Ala Arg
 710                 715                 720                 725

 ctg ctc cgg gtg ctg cag gac ctc cgc gag gcc cat agc tcc agc ccg     2263
 Leu Leu Arg Val Leu Gln Asp Leu Arg Glu Ala His Ser Ser Ser Pro
                 730                 735                 740

 gcc ggc tcc cca ccc tca gag ccc aac tgc ctc ctg gag ctg cag acg     2311
 Ala Gly Ser Pro Pro Ser Glu Pro Asn Cys Leu Leu Glu Leu Gln Thr
             745                 750                 755

 tga ggcc cgccctacgc tccccttgct gagtcccctg ccaagcgctc ggagcccccc     2368
 






      <210> 498
      <211> 1959
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (86)..(1633)

      <400> 498
 ggcagccact gccaccgcca cagccacagc caccgtggct gctctccagg agaagcagag     60

 ccaggagctg agccagtatg gagcg  atg ggg gcc gga cag tct ttt aac agc     112
                              Met Gly Ala Gly Gln Ser Phe Asn Ser
                                1               5

 cag ttt ctg cag cat gga ggt ccc cgg ggg cct agt gtc ccc gct ggc      160
 Gln Phe Leu Gln His Gly Gly Pro Arg Gly Pro Ser Val Pro Ala Gly
  10                  15                  20                  25

 atg aac cct act ggc ata gga ggg gta atg ggc ccc tct ggc ctc tcc      208
 Met Asn Pro Thr Gly Ile Gly Gly Val Met Gly Pro Ser Gly Leu Ser
                  30                  35                  40

 ccc ttg gct atg aac ccc acc cgg gca gca gga atg aca ccc ttg tat      256
 Pro Leu Ala Met Asn Pro Thr Arg Ala Ala Gly Met Thr Pro Leu Tyr
              45                  50                  55

 gca ggg cag cgt ctg ccc caa cat ggg tat cct ggg cct ccc cag gcc      304
 Ala Gly Gln Arg Leu Pro Gln His Gly Tyr Pro Gly Pro Pro Gln Ala
          60                  65                  70

 cag cca ctg ccc cga cag ggg gtc aag aga acc tac tct gag gtg tat      352
 Gln Pro Leu Pro Arg Gln Gly Val Lys Arg Thr Tyr Ser Glu Val Tyr
      75                  80                  85

 cca ggg cag cag tat ctg caa gga ggc cag tat gca ccc agc acc gcc      400
 Pro Gly Gln Gln Tyr Leu Gln Gly Gly Gln Tyr Ala Pro Ser Thr Ala
  90                  95                 100                 105

 cag ttt gcg ccc agc cct ggg cag ccc cct gcc ccc tcc cct tcc tac      448
 Gln Phe Ala Pro Ser Pro Gly Gln Pro Pro Ala Pro Ser Pro Ser Tyr
                 110                 115                 120

 cct ggg cac agg ctg ccc ctg cag cag ggc atg acc cag tcc ctg tcc      496
 Pro Gly His Arg Leu Pro Leu Gln Gln Gly Met Thr Gln Ser Leu Ser
             125                 130                 135

 gtg cct ggc ccc acg gga ctg cat tat aag ccc aca gag cag ttc aac      544
 Val Pro Gly Pro Thr Gly Leu His Tyr Lys Pro Thr Glu Gln Phe Asn
         140                 145                 150

 ggg cag ggc gcc agc ttc aac ggg ggc agc gtc agc tac agc caa cct      592
 Gly Gln Gly Ala Ser Phe Asn Gly Gly Ser Val Ser Tyr Ser Gln Pro
     155                 160                 165

 ggc ctg agt ggg cct acc cgt tcc atc ccg ggc tat ccc agt tcc cca      640
 Gly Leu Ser Gly Pro Thr Arg Ser Ile Pro Gly Tyr Pro Ser Ser Pro
 170                 175                 180                 185

 ctg cca ggg aac ccc acg cca ccc atg acc cca agc agc agc gtc cct      688
 Leu Pro Gly Asn Pro Thr Pro Pro Met Thr Pro Ser Ser Ser Val Pro
                 190                 195                 200

 tac atg tca cca aac caa gag gtc aag tct ccc ttc ttg cct gat ctc      736
 Tyr Met Ser Pro Asn Gln Glu Val Lys Ser Pro Phe Leu Pro Asp Leu
             205                 210                 215

 aag ccc aac ctc aac tcc ttg cac tca tcg ccc tct gga agc ggg cct      784
 Lys Pro Asn Leu Asn Ser Leu His Ser Ser Pro Ser Gly Ser Gly Pro
         220                 225                 230

 tgt gac gag ttg cgg ctg acc ttc cct gtg cgc gat ggg gtg gtc ctg      832
 Cys Asp Glu Leu Arg Leu Thr Phe Pro Val Arg Asp Gly Val Val Leu
     235                 240                 245

 gag ccc ttc cgc ctg cag cac aac ctg gct gta agc aac cat gtc ttc      880
 Glu Pro Phe Arg Leu Gln His Asn Leu Ala Val Ser Asn His Val Phe
 250                 255                 260                 265

 cag ctg cga gac tca gtc tac aag acc ctg ata atg agg cct gac ctg      928
 Gln Leu Arg Asp Ser Val Tyr Lys Thr Leu Ile Met Arg Pro Asp Leu
                 270                 275                 280

 gag ctg caa ttc aag tgc tac cac cac gag gac cgg cag atg aac acc      976
 Glu Leu Gln Phe Lys Cys Tyr His His Glu Asp Arg Gln Met Asn Thr
             285                 290                 295

 aac tgg cca gcc tcg gtg cag gtc agc gtc aat gcc acg ccg ctc acc     1024
 Asn Trp Pro Ala Ser Val Gln Val Ser Val Asn Ala Thr Pro Leu Thr
         300                 305                 310

 atc gag cgt ggc gac aac aag acc tcg cac aag cca ctc tac ctg aag     1072
 Ile Glu Arg Gly Asp Asn Lys Thr Ser His Lys Pro Leu Tyr Leu Lys
     315                 320                 325

 cat gtg tgc cag cca ggc cgc aac acc atc cag atc acc gtc acc gcc     1120
 His Val Cys Gln Pro Gly Arg Asn Thr Ile Gln Ile Thr Val Thr Ala
 330                 335                 340                 345

 tgc tgc tgc tcc cac ctc ttc gtg ctg cag cta gtg cac cgc cca tcc     1168
 Cys Cys Cys Ser His Leu Phe Val Leu Gln Leu Val His Arg Pro Ser
                 350                 355                 360

 gtc cgc tcg gtg ctg cag ggc ctc ctc aaa aag cgc ctc ctg cct gct     1216
 Val Arg Ser Val Leu Gln Gly Leu Leu Lys Lys Arg Leu Leu Pro Ala
             365                 370                 375

 gag cac tgc atc acc aag ata aag cgg aac ttc agc agc ggc acc atc     1264
 Glu His Cys Ile Thr Lys Ile Lys Arg Asn Phe Ser Ser Gly Thr Ile
         380                 385                 390

 cct ggc acc cct ggg ccc aac gga gag gac ggg gtg gag cag aca gct     1312
 Pro Gly Thr Pro Gly Pro Asn Gly Glu Asp Gly Val Glu Gln Thr Ala
     395                 400                 405

 atc aag gtg tcc ctg aag tgc ccc atc acc ttc cgc agg atc cag ctc     1360
 Ile Lys Val Ser Leu Lys Cys Pro Ile Thr Phe Arg Arg Ile Gln Leu
 410                 415                 420                 425

 cct gcc cga ggt cat gac tgt cgc cac ata cag tgc ttt gac ctg gag     1408
 Pro Ala Arg Gly His Asp Cys Arg His Ile Gln Cys Phe Asp Leu Glu
                 430                 435                 440

 tcg tac ctg cag ctc aac tgt gag cgg ggg act tgg agg tgt cct gtg     1456
 Ser Tyr Leu Gln Leu Asn Cys Glu Arg Gly Thr Trp Arg Cys Pro Val
             445                 450                 455

 tgc aac aag aca gct ttg ctg gag ggc ctg gag gtg gac cag tac atg     1504
 Cys Asn Lys Thr Ala Leu Leu Glu Gly Leu Glu Val Asp Gln Tyr Met
         460                 465                 470

 ctg ggc atc ctg att tac att cag aac tct gac tat gag gag atc acc     1552
 Leu Gly Ile Leu Ile Tyr Ile Gln Asn Ser Asp Tyr Glu Glu Ile Thr
     475                 480                 485

 atc gac ccc acg tgc agc tgg aag cca gtg ccc gtg aag cct gac atg     1600
 Ile Asp Pro Thr Cys Ser Trp Lys Pro Val Pro Val Lys Pro Asp Met
 490                 495                 500                 505

 cac atc aag gag gag ccg gat ggg ccg cac tga agcgctga cgcaccgtga     1651
 His Ile Lys Glu Glu Pro Asp Gly Pro His 
                 510                 515

 gcccccgcca cgtgctcatg ccagcgtgat ggagatgatc gcgaactggg accgaaagct   1711

 gccaaaagaa aacacaaaac aaaaaacaac acccaaccaa gcaacacccc cacacaaacc   1771

 tcgaacgaga gcacggcggc aagcagccag caggcagacg cccgcgggcc cacagccggt   1831

 cacccgcggc aggcgcgaca ttgccgacag ggcgacgcga agaaaagacg cgcgacagga   1891

 aggcgggcgc gacgagacag tgacgcagcg gccgggcgcg caacctgcgc cgagatggcg   1951

 cgtagccc                                                            1959




      <210> 499
      <211> 1218
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (120)..(863)

      <400> 499
 cccccgcttg gcttccagcg ccgcttgcgc tccggagcgc tggctctgct ggcgctgaga     60

 aatggaccaa ttttgacaag atatagtgct gcagcgtgcc tgatgggata tattcagtc     119                                                                 
 atg gcg tcc gaa ctt tgt aag acg atc tct gtg gca agg cta gaa aag      167
 Met Ala Ser Glu Leu Cys Lys Thr Ile Ser Val Ala Arg Leu Glu Lys
   1               5                  10                  15

 cac aag aat ttg ttc tta aat tat agg aat ctg cac cat ttt cca ttg      215
 His Lys Asn Leu Phe Leu Asn Tyr Arg Asn Leu His His Phe Pro Leu
              20                  25                  30

 gag tta ctg aaa gat gag gga ctg cag tac ttg gag aga ctc tat atg      263
 Glu Leu Leu Lys Asp Glu Gly Leu Gln Tyr Leu Glu Arg Leu Tyr Met
          35                  40                  45

 aaa agg aac tcc ctg aca tcc ttg cca gaa aac ctt gct cag aag ctt      311
 Lys Arg Asn Ser Leu Thr Ser Leu Pro Glu Asn Leu Ala Gln Lys Leu
      50                  55                  60

 cca aac ctt gtg gaa cta tac ctg cac tca aat aac ata gtt gtg gtt      359
 Pro Asn Leu Val Glu Leu Tyr Leu His Ser Asn Asn Ile Val Val Val
  65                  70                  75                  80

 ccg gaa gcc att ggg tct ctt gta aaa ctc caa tgt ctg gat ctt agt      407
 Pro Glu Ala Ile Gly Ser Leu Val Lys Leu Gln Cys Leu Asp Leu Ser
                  85                  90                  95

 gac aat gcc tta aaa att gtt tgc cca gaa att ggt cgt ctg aga gct      455
 Asp Asn Ala Leu Lys Ile Val Cys Pro Glu Ile Gly Arg Leu Arg Ala
             100                 105                 110

 tta cgt cat ctt cga tta gct aat aac caa ctg caa ttc cta cct cca      503
 Leu Arg His Leu Arg Leu Ala Asn Asn Gln Leu Gln Phe Leu Pro Pro
         115                 120                 125

 gag gtt ggc gat ttg aag gag ctg cag aca cta gac att tct acc aat      551
 Glu Val Gly Asp Leu Lys Glu Leu Gln Thr Leu Asp Ile Ser Thr Asn
     130                 135                 140

 cgt ttg cta act tta ccc gag agg ctt cac atg tgc ctt tct ctg cag      599
 Arg Leu Leu Thr Leu Pro Glu Arg Leu His Met Cys Leu Ser Leu Gln
 145                 150                 155                 160

 tac ctc act gtg gac cga aat cgt cta tgg tat gtg ccg cgc cat ctc      647
 Tyr Leu Thr Val Asp Arg Asn Arg Leu Trp Tyr Val Pro Arg His Leu
                 165                 170                 175

 tgc cag ctg ccc agc ctc aat gag ctc tcc atg gct gga aac cgt ctt      695
 Cys Gln Leu Pro Ser Leu Asn Glu Leu Ser Met Ala Gly Asn Arg Leu
             180                 185                 190

 gca ttt ttg cca ctt gat tta ggt cga tct cga gaa cta cag tat gta      743
 Ala Phe Leu Pro Leu Asp Leu Gly Arg Ser Arg Glu Leu Gln Tyr Val
         195                 200                 205

 tac gtg gat aac aac att cac ctg aaa ggc ttg cca tct tat ctg tac      791
 Tyr Val Asp Asn Asn Ile His Leu Lys Gly Leu Pro Ser Tyr Leu Tyr
     210                 215                 220

 aat aaa gtc atc ggg tgc agt ggg tca acc cta ttc aca gta gga ggt      839
 Asn Lys Val Ile Gly Cys Ser Gly Ser Thr Leu Phe Thr Val Gly Gly
 225                 230                 235                 240

 gac tac atg gag agt gac cac tag gagcgaggac cattgggggc ccacttggag     893
 Asp Tyr Met Glu Ser Asp His 
                 245

 actggctgtc acagcttcat ggcatctata ctatttgcta gcctcatgga aaagaatgat    953

 ctttattttt tctgggtttt tcttgttatt acaggagtaa atgtcctcaa tcttctacat   1013

 tgtagccaga aagagaggtt catcccatgt tagaatttta gagaatggta attggcacat   1073

 atacttactg aggagaactt aatggtaaaa gtaatcctct acaggatgtt ttttccaatt   1133

 gtttaattat gtaagaaaaa aaaaaaaaaa aaaaacaaaa ttggcggtca agcttattcc   1193

 tttattgttt tttttttgct actat                                         1218




      <210> 500
      <211> 1341
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (5)..(1099)

      <400> 500
 aacg atg gtc ctc agc tcg gtg aca agg atc tca ttt gcc caa cgg ggt      49
      Met Val Leu Ser Ser Val Thr Arg Ile Ser Phe Ala Gln Arg Gly
        1               5                  10                  15

 act cca gca ggt act tca agt cca gct tct tca tct tcc ctt ctc aac       97
 Thr Pro Ala Gly Thr Ser Ser Pro Ala Ser Ser Ser Ser Leu Leu Asn
                  20                  25                  30

 aga ctt cag ctt gat gat gat att gat ggt gag act aga gat ctc ttc      145
 Arg Leu Gln Leu Asp Asp Asp Ile Asp Gly Glu Thr Arg Asp Leu Phe
              35                  40                  45

 gtt ata gtc gat gat ccc aag aag cat gtg tgt aca atg gag act tac      193
 Val Ile Val Asp Asp Pro Lys Lys His Val Cys Thr Met Glu Thr Tyr
          50                  55                  60

 atc acc tat agg atc acc acc aaa agt act cgg gtg gag ttt gac ctc      241
 Ile Thr Tyr Arg Ile Thr Thr Lys Ser Thr Arg Val Glu Phe Asp Leu
      65                  70                  75

 cca gaa tat tct gtt cgt cga aga tac cag gat ttt gac tgg ttg agg      289
 Pro Glu Tyr Ser Val Arg Arg Arg Tyr Gln Asp Phe Asp Trp Leu Arg
  80                  85                  90                  95

 agc aaa ctg gaa gaa tcc cag ccc act cat ctc att tcc cct ctt ccc      337
 Ser Lys Leu Glu Glu Ser Gln Pro Thr His Leu Ile Ser Pro Leu Pro
                 100                 105                 110

 gag aag ttt gtg gta aaa ggt gtt gtg gat cgt ttt tca gaa gag ttt      385
 Glu Lys Phe Val Val Lys Gly Val Val Asp Arg Phe Ser Glu Glu Phe
             115                 120                 125

 gtg gag acc aga aga aaa gct ttg gat aaa ttt cta aaa aga att acg      433
 Val Glu Thr Arg Arg Lys Ala Leu Asp Lys Phe Leu Lys Arg Ile Thr
         130                 135                 140

 gac cat cct gtg ctg tct ttc aat gaa cac ttt aat att ttc ctt act      481
 Asp His Pro Val Leu Ser Phe Asn Glu His Phe Asn Ile Phe Leu Thr
     145                 150                 155

 gct aag gac ctg aac gcc tac aag aag caa ggg ata gca ttg ctg acc      529
 Ala Lys Asp Leu Asn Ala Tyr Lys Lys Gln Gly Ile Ala Leu Leu Thr
 160                 165                 170                 175

 aga atg ggc gag tca gtc aag cac gtc act ggc ggc tac aag ctg agg      577
 Arg Met Gly Glu Ser Val Lys His Val Thr Gly Gly Tyr Lys Leu Arg
                 180                 185                 190

 act cgg ccg ctt gag ttt gct gcc ata ggt gac tac tta gat aca ttt      625
 Thr Arg Pro Leu Glu Phe Ala Ala Ile Gly Asp Tyr Leu Asp Thr Phe
             195                 200                 205

 gca ctc aaa ctg gga acc att gat cga ata gcc cag cgg atc atc aaa      673
 Ala Leu Lys Leu Gly Thr Ile Asp Arg Ile Ala Gln Arg Ile Ile Lys
         210                 215                 220

 gaa gaa ata gag tac ctt gtg gag ctg aga gaa tac ggg cct gtg tac      721
 Glu Glu Ile Glu Tyr Leu Val Glu Leu Arg Glu Tyr Gly Pro Val Tyr
     225                 230                 235

 tcc aca tgg agc gcc ttg gag ggt gag ctg gct gaa ccc ctg gag ggt      769
 Ser Thr Trp Ser Ala Leu Glu Gly Glu Leu Ala Glu Pro Leu Glu Gly
 240                 245                 250                 255

 gtg tca gct tgc att ggg aac tgc tct aca gcc tta gaa gag ctg aca      817
 Val Ser Ala Cys Ile Gly Asn Cys Ser Thr Ala Leu Glu Glu Leu Thr
                 260                 265                 270

 gat gac atg aca gaa gac ttc cta cct gtg ctc agg gaa tat att tta      865
 Asp Asp Met Thr Glu Asp Phe Leu Pro Val Leu Arg Glu Tyr Ile Leu
             275                 280                 285

 tac tct gac tcc atg aag agt gta ttg aag aag agg gac caa gtt caa      913
 Tyr Ser Asp Ser Met Lys Ser Val Leu Lys Lys Arg Asp Gln Val Gln
         290                 295                 300

 gca gag tat gaa gcc aaa ctg gaa gct gtg gct ctg cgg aag gaa gac      961
 Ala Glu Tyr Glu Ala Lys Leu Glu Ala Val Ala Leu Arg Lys Glu Asp
     305                 310                 315

 cgc ccc aag gta ccg gcg gac gtc gac aaa tgt cag gat cgg atg gag     1009
 Arg Pro Lys Val Pro Ala Asp Val Asp Lys Cys Gln Asp Arg Met Glu
 320                 325                 330                 335

 tgt ttc aat gct gac ctg aaa gct gac atg gag agg tgg cag aac aac     1057
 Cys Phe Asn Ala Asp Leu Lys Ala Asp Met Glu Arg Trp Gln Asn Asn
                 340                 345                 350

 aag agg cag gac ttc cgg cca gct act cat gcg gat ggc tga caagaac     1106
 Lys Arg Gln Asp Phe Arg Pro Ala Thr His Ala Asp Gly 
             355                 360

 atccagtatt tatgaagaac gtgcctcatg ccgacggcag tcgattattt cccataatgc   1166

 acgccacaac cagaggccac taaagtcttt ctggcggacg gaccctctta cttaaccggc   1226

 ctggccctat ccggaatttc ctacatgcag agaccatgcg gcaaacaccc acacactact   1286

 ctatatctat gcagccaaat cctccactgc cactcctccc gccgctacac accca        1341




      <210> 501
      <211> 1674
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (43)..(1323)

      <220>
      <221> misc_feature
      <222> (1)...(1674)
      <223> n = a,t,c or g

      <400> 501
 attttnaatt ganngggcgt gatttatata actatctatt cg   atg atg aag ata      54
                                                  Met Met Lys Ile
                                                    1

 ccc cac caa acc caa aaa aag aga tct ctc gag gat ccg aat tcg cgg      102
 Pro His Gln Thr Gln Lys Lys Arg Ser Leu Glu Asp Pro Asn Ser Arg
   5                  10                  15                  20

 ccg cgt cga cgg aga agc aag atg gcg gcg acg gcg gcc gca gtg gtg      150
 Pro Arg Arg Arg Arg Ser Lys Met Ala Ala Thr Ala Ala Ala Val Val
                  25                  30                  35

 gcc gag gag gac acg gag ctg cgg gac ctg ctg gtg cag acg ctg gag      198
 Ala Glu Glu Asp Thr Glu Leu Arg Asp Leu Leu Val Gln Thr Leu Glu
              40                  45                  50

 aac agc ggg gtc ctg aac cgc atc aag gct gaa ctc cga gca gct gtg      246
 Asn Ser Gly Val Leu Asn Arg Ile Lys Ala Glu Leu Arg Ala Ala Val
          55                  60                  65

 ttt tta gca cta gag gag caa gaa aaa gta gag aac aaa act cct tta      294
 Phe Leu Ala Leu Glu Glu Gln Glu Lys Val Glu Asn Lys Thr Pro Leu
      70                  75                  80

 gtt aat gag agc ctg aaa aag ttt tta aat acc aaa gac ggt cgt tta      342
 Val Asn Glu Ser Leu Lys Lys Phe Leu Asn Thr Lys Asp Gly Arg Leu
  85                  90                  95                 100

 gtg gct agt ctt gtt gca gaa ttt ctt cag ttt ttt aac ctt gac ttt      390
 Val Ala Ser Leu Val Ala Glu Phe Leu Gln Phe Phe Asn Leu Asp Phe
                 105                 110                 115

 act ttg gct gtt ttt caa cct gaa act agc aca ctg caa ggt ctc gaa      438
 Thr Leu Ala Val Phe Gln Pro Glu Thr Ser Thr Leu Gln Gly Leu Glu
             120                 125                 130

 ggt cga gag aat tta gcc cga gat tta ggt ata att gaa gca gaa ggt      486
 Gly Arg Glu Asn Leu Ala Arg Asp Leu Gly Ile Ile Glu Ala Glu Gly
         135                 140                 145

 act gtg ggt gga ccc tta tta tta gaa gtg atc agg cgc tgt caa cag      534
 Thr Val Gly Gly Pro Leu Leu Leu Glu Val Ile Arg Arg Cys Gln Gln
     150                 155                 160

 aaa gaa aaa ggg cca acc act ggg gaa ggt gca ctt gat cta tct gat      582
 Lys Glu Lys Gly Pro Thr Thr Gly Glu Gly Ala Leu Asp Leu Ser Asp
 165                 170                 175                 180

 gta cat tct cca cca aag tca cca gag gga aaa aca agt gca cag aca      630
 Val His Ser Pro Pro Lys Ser Pro Glu Gly Lys Thr Ser Ala Gln Thr
                 185                 190                 195

 aca cca agt aag ata cca agg tat aaa gga caa ggt aag aag aag aca      678
 Thr Pro Ser Lys Ile Pro Arg Tyr Lys Gly Gln Gly Lys Lys Lys Thr
             200                 205                 210

 agc ggg cag aag gct ggt gac aag aag gcc aat gat gag gcc aat cag      726
 Ser Gly Gln Lys Ala Gly Asp Lys Lys Ala Asn Asp Glu Ala Asn Gln
         215                 220                 225

 agt gat aca agt gtc tcc ttg tca gaa ccc aag agc aaa agc agc ctt      774
 Ser Asp Thr Ser Val Ser Leu Ser Glu Pro Lys Ser Lys Ser Ser Leu
     230                 235                 240

 cac tta ctg tcc cat gaa aca aaa att gta tct ttt cta agc aac aga      822
 His Leu Leu Ser His Glu Thr Lys Ile Val Ser Phe Leu Ser Asn Arg
 245                 250                 255                 260

 act tta gat ggc aaa gac aaa gct ggc ctt tgt cca gat gaa gat gat      870
 Thr Leu Asp Gly Lys Asp Lys Ala Gly Leu Cys Pro Asp Glu Asp Asp
                 265                 270                 275

 atg gaa gga gat tct ttc ttt gat gat ccc att cct aag cca gag aaa      918
 Met Glu Gly Asp Ser Phe Phe Asp Asp Pro Ile Pro Lys Pro Glu Lys
             280                 285                 290

 act tac ggt ttg agg aag gaa cct agg aag caa gca gga agt ctg gcc      966
 Thr Tyr Gly Leu Arg Lys Glu Pro Arg Lys Gln Ala Gly Ser Leu Ala
         295                 300                 305

 tcg ctc tcg gat gca ccc ccc tta aaa agt gga ctc agc tcc ctg gcg     1014
 Ser Leu Ser Asp Ala Pro Pro Leu Lys Ser Gly Leu Ser Ser Leu Ala
     310                 315                 320

 gga gcc cct tct tta aaa gac tct gag agt aaa agg gga aat aca gtt     1062
 Gly Ala Pro Ser Leu Lys Asp Ser Glu Ser Lys Arg Gly Asn Thr Val
 325                 330                 335                 340

 ttg aaa gat ctg aaa ttg atc agt gat aaa att gga tca ctt gga tta     1110
 Leu Lys Asp Leu Lys Leu Ile Ser Asp Lys Ile Gly Ser Leu Gly Leu
                 345                 350                 355

 gga act gga gaa gat gat gac tat gtt gat gat ttt aat agt acc agc     1158
 Gly Thr Gly Glu Asp Asp Asp Tyr Val Asp Asp Phe Asn Ser Thr Ser
             360                 365                 370

 cat cgc tca gag aaa agt gag ata agt att ggt gaa gag ata gaa gaa     1206
 His Arg Ser Glu Lys Ser Glu Ile Ser Ile Gly Glu Glu Ile Glu Glu
         375                 380                 385

 gac ctt tct gtg gaa ata gat gac atc aat acc agt gat aag ctt gat     1254
 Asp Leu Ser Val Glu Ile Asp Asp Ile Asn Thr Ser Asp Lys Leu Asp
     390                 395                 400

 gac ctc aca caa gat ctg act gta tcc cag ctc agt gat gtt gcg gat     1302
 Asp Leu Thr Gln Asp Leu Thr Val Ser Gln Leu Ser Asp Val Ala Asp
 405                 410                 415                 420

 tat ctg gaa gat gtt gca tag ac acgaagaagg aagtattcta attaacaagg     1355
 Tyr Leu Glu Asp Val Ala 
                 425

 acagaggact gaccggttcc attttttttt ttttccagac aatcactcag ctggaatgtc   1415

 tgctctctat tggtgccttg catttcaaaa acactgcaga tattttttaa aagtaatttt   1475

 cattttacta aacaaaatac ttcctatttg agcccatgtg tggaagattt aatattctta   1535

 atttaactgt acatttcttt atggaaattg attatctaca ctcagtttca ttacagggaa   1595

 ggaacccatg aaaacatcag tgttaagagc atgatgaaag gtgtcaataa agccgtagga   1655

 tcgcgcaaaa aaaaaaaaa                                                1674




      <210> 502
      <211> 1614
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (43)..(1263)

      <220>
      <221> misc_feature
      <222> (1)...(1614)
      <223> n = a,t,c or g

      <400> 502
 attttnaatt ganngggcgt gatttatata actatctatt cg   atg atg aag ata      54
                                                  Met Met Lys Ile
                                                    1

 ccc cac caa acc caa aaa aag aga tct ctc gag gat ccg aat tcg cgg      102
 Pro His Gln Thr Gln Lys Lys Arg Ser Leu Glu Asp Pro Asn Ser Arg
   5                  10                  15                  20

 ccg cgt cga cgg aga agc aag atg gcg gcg acg gcg gcc gca gtg gtg      150
 Pro Arg Arg Arg Arg Ser Lys Met Ala Ala Thr Ala Ala Ala Val Val
                  25                  30                  35

 gcc gag gag gac acg gag ctg cgg gac ctg ctg gtg cag acg ctg gag      198
 Ala Glu Glu Asp Thr Glu Leu Arg Asp Leu Leu Val Gln Thr Leu Glu
              40                  45                  50

 aac agc ggg gtc ctg aac cgc atc aag gct gaa ctc cga gca gct gtg      246
 Asn Ser Gly Val Leu Asn Arg Ile Lys Ala Glu Leu Arg Ala Ala Val
          55                  60                  65

 ttt tta gca cta gag gag caa gaa aaa gta gag aac aaa act cct tta      294
 Phe Leu Ala Leu Glu Glu Gln Glu Lys Val Glu Asn Lys Thr Pro Leu
      70                  75                  80

 gtt aat gag agc ctg aaa aag ttt tta aat acc aaa gac ggt cgt tta      342
 Val Asn Glu Ser Leu Lys Lys Phe Leu Asn Thr Lys Asp Gly Arg Leu
  85                  90                  95                 100

 gtg gct agt ctt gtt gca gaa ttt ctt cag ttt ttt aac ctt gac ttt      390
 Val Ala Ser Leu Val Ala Glu Phe Leu Gln Phe Phe Asn Leu Asp Phe
                 105                 110                 115

 act ttg gct gtt ttt caa cct gaa act agc aca ctg caa ggt ctc gaa      438
 Thr Leu Ala Val Phe Gln Pro Glu Thr Ser Thr Leu Gln Gly Leu Glu
             120                 125                 130

 ggt cga gag aat tta gcc cga gat tta ggt ata att gaa gca gaa ggt      486
 Gly Arg Glu Asn Leu Ala Arg Asp Leu Gly Ile Ile Glu Ala Glu Gly
         135                 140                 145

 act gtg ggt gga ccc tta tta tta gaa gtg atc agg cgc tgt caa cag      534
 Thr Val Gly Gly Pro Leu Leu Leu Glu Val Ile Arg Arg Cys Gln Gln
     150                 155                 160

 aaa gaa aaa ggg cca acc act ggg gaa ggt gca ctt gat cta tct gat      582
 Lys Glu Lys Gly Pro Thr Thr Gly Glu Gly Ala Leu Asp Leu Ser Asp
 165                 170                 175                 180

 gta cat tct cca cca aag tca cca gag gga aaa aca agt gca cag aca      630
 Val His Ser Pro Pro Lys Ser Pro Glu Gly Lys Thr Ser Ala Gln Thr
                 185                 190                 195

 aca cca agt aag aag gcc aat gat gag gcc aat cag agt gat aca agt      678
 Thr Pro Ser Lys Lys Ala Asn Asp Glu Ala Asn Gln Ser Asp Thr Ser
             200                 205                 210

 gtc tcc ttg tca gaa ccc aag agc aaa agc agc ctt cac tta ctg tcc      726
 Val Ser Leu Ser Glu Pro Lys Ser Lys Ser Ser Leu His Leu Leu Ser
         215                 220                 225

 cat gaa aca aaa att gta tct ttt cta agc aac aga act tta gat ggc      774
 His Glu Thr Lys Ile Val Ser Phe Leu Ser Asn Arg Thr Leu Asp Gly
     230                 235                 240

 aaa gac aaa gct ggc ctt tgt cca gat gaa gat gat atg gaa gga gat      822
 Lys Asp Lys Ala Gly Leu Cys Pro Asp Glu Asp Asp Met Glu Gly Asp
 245                 250                 255                 260

 tct ttc ttt gat gat ccc att cct aag cca gag aaa act tac ggt ttg      870
 Ser Phe Phe Asp Asp Pro Ile Pro Lys Pro Glu Lys Thr Tyr Gly Leu
                 265                 270                 275

 agg aag gaa cct agg aag caa gca gga agt ctg gcc tcg ctc tcg gat      918
 Arg Lys Glu Pro Arg Lys Gln Ala Gly Ser Leu Ala Ser Leu Ser Asp
             280                 285                 290

 gca ccc ccc tta aaa agt gga ctc agc tcc ctg gcg gga gcc cct tct      966
 Ala Pro Pro Leu Lys Ser Gly Leu Ser Ser Leu Ala Gly Ala Pro Ser
         295                 300                 305

 tta aaa gac tct gag agt aaa agg gga aat aca gtt ttg aaa gat ctg     1014
 Leu Lys Asp Ser Glu Ser Lys Arg Gly Asn Thr Val Leu Lys Asp Leu
     310                 315                 320

 aaa ttg atc agt gat aaa att gga tca ctt gga tta gga act gga gaa     1062
 Lys Leu Ile Ser Asp Lys Ile Gly Ser Leu Gly Leu Gly Thr Gly Glu
 325                 330                 335                 340

 gat gat gac tat gtt gat gat ttt aat agt acc agc cat cgc tca gag     1110
 Asp Asp Asp Tyr Val Asp Asp Phe Asn Ser Thr Ser His Arg Ser Glu
                 345                 350                 355

 aaa agt gag ata agt att ggt gaa gag ata gaa gaa gac ctt tct gtg     1158
 Lys Ser Glu Ile Ser Ile Gly Glu Glu Ile Glu Glu Asp Leu Ser Val
             360                 365                 370

 gaa ata gat gac atc aat acc agt gat aag ctt gat gac ctc aca caa     1206
 Glu Ile Asp Asp Ile Asn Thr Ser Asp Lys Leu Asp Asp Leu Thr Gln
         375                 380                 385

 gat ctg act gta tcc cag ctc agt gat gtt gcg gat tat ctg gaa gat     1254
 Asp Leu Thr Val Ser Gln Leu Ser Asp Val Ala Asp Tyr Leu Glu Asp
     390                 395                 400

 gtt gca tag acacgaa gaaggaagta ttctaattaa caaggacaga ggactgaccg     1310
 Val Ala 
 405

 gttccatttt tttttttttc cagacaatca ctcagctgga atgtctgctc tctattggtg   1370

 ccttgcattt caaaaacact gcagatattt tttaaaagta attttcattt tactaaacaa   1430

 aatacttcct atttgagccc atgtgtggaa gatttaatat tcttaattta actgtacatt   1490

 tctttatgga aattgattat ctacactcag tttcattaca gggaaggaac ccatgaaaac   1550

 atcagtgtta agagcatgat gaaaggtgtc aataaagccg taggatcgcg caaaaaaaaa   1610

 aaaa                                                                1614




      <210> 503
      <211> 1394
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (133)..(390)

      <400> 503
 atgatccttg gtcaaatagt tgaggatccc ctgagactgg atgtagattc cataggtcgg     60

 gaagaaatgg gttttcctct ccacagaaca agaactcagg accttctgaa tggcaaagct    120

 aaaatagctg aa    atg caa aca ggg ctg aaa cat gcc cct tgc tca cca     168
                  Met Gln Thr Gly Leu Lys His Ala Pro Cys Ser Pro
                    1               5                  10

 tat tgc agg caa aga aga caa aaa ctg cag cca ttc agg gaa ccc aga      216
 Tyr Cys Arg Gln Arg Arg Gln Lys Leu Gln Pro Phe Arg Glu Pro Arg
          15                  20                  25

 ctt ggg agc tcc cca aga cac ggc tgt aac tcc ctc ttt ggg act ctg      264
 Leu Gly Ser Ser Pro Arg His Gly Cys Asn Ser Leu Phe Gly Thr Leu
      30                  35                  40

 tgg ttc ctg gca tct cca agc ttc tgg gtg cca cca cat ttc ccg gtg      312
 Trp Phe Leu Ala Ser Pro Ser Phe Trp Val Pro Pro His Phe Pro Val
  45                  50                  55                  60

 cca gct ggg gaa gct gtc tgc agt gca cct ggt cca gcc gca gcc tca      360
 Pro Ala Gly Glu Ala Val Cys Ser Ala Pro Gly Pro Ala Ala Ala Ser
                  65                  70                  75

 cag aga gcc agt gcc cat gct ggc acc tag a gctgacagcc ccacagcagc      411
 Gln Arg Ala Ser Ala His Ala Gly Thr 
              80                  85

 agccagcatg tctgactgtg cagtagccca accccgcact cactcacaca cgtcttgcca    471

 gtccacgcct gactcagtct cccttggagg atccctaagg agggttttgg gaatttgtga    531

 acgtttcagt tgtcacaatc actgggggat gctactggca ctgagtgggt ggaaaccagg    591

 aacactagag gtcctaagac acccaggaca gtctgcacgg ccaaagactt ctgcattcct    651

 cacaacttcc tcaagtcctg ctgaatattc agcaatccca aaggtggatg ttaataacac    711

 cattttacaa atgaaaattt tgaagataca gcataacttg gttaaagcca agttatcagt    771

 ggatagttgc aaagctgaag caatcaaccc agagctgtat gttcttcgct tttaaatgct    831

 actattcccc atcctctacc taagttcacc attagttgca tataaaactc ccccattgaa    891

 aagttcatct ccttaagttc aatcctgtag caaatcccac acatcctgcc gccttcttac    951

 catgtcctct aatccaaagc acactgtcct tgtgtccaga ctattctaac agcctcctaa   1011

 ctggtctccc ttcttccagc gtggccctct ggagtagctt ctataaagct gccagaatga   1071

 ggattacatc acaaatcaga tcctaattct tttctattta atagctccca tttgtttcca   1131

 attccaatta gaatgacatc caaatgccta cattcttaca agtcctgcac aatgcagccc   1191

 ttgcgatatg cagagatgtt accaaagaag ttcttatgct ggagccactg catctctgct   1251

 tccatctctt ccatctaccc ccacagattg ctacaagttg gactcttttt cactcttcag   1311

 tccaagcctt cagggtgtgt gtgtgtgggg ggaggggggt gttgtaggct tttgtgtgta   1371

 agtgtgacag agaggttttt gat                                           1394




      <210> 504
      <211> 2333
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (270)..(1253)

      <400> 504
 taagcttgcg gccgcacgcg gggccgcgcg ccgaggatgc gggactagcc gggcaggctg     60

 cgggcggccg tcgggccagc gaggcctcgc agcgggcggg ccctggcgag tagtggccgg    120

 gcgccgcccc ctgcgccctg aggcccgggc cccgccgctt ctgctttccc gcttctcgcg    180

 gcagtggcgg ccgaggaggc gcccgcgccg gccgcccccg ggggaagccg cgccgtctcc    240

 gcctgcccgg cgccctgacg gccgctgtt  atg cgt att ccc gta gac cca agc     293
                                  Met Arg Ile Pro Val Asp Pro Ser
                                    1               5

 acc agc cgc cgc ttc aca cct ccc tcc ccg gcc ttc ccc tgc ggc ggc      341
 Thr Ser Arg Arg Phe Thr Pro Pro Ser Pro Ala Phe Pro Cys Gly Gly
      10                  15                  20

 ggc ggc ggc aag atg ggc gag aac agc ggc gcg ctg agc gcg cag gcg      389
 Gly Gly Gly Lys Met Gly Glu Asn Ser Gly Ala Leu Ser Ala Gln Ala
  25                  30                  35                  40

 gcc gtg ggg ccc gga ggg cgc gcc cgg ccc gag gtg cgc tcg atg gtg      437
 Ala Val Gly Pro Gly Gly Arg Ala Arg Pro Glu Val Arg Ser Met Val
                  45                  50                  55

 gac gtg ctg gcg gac cac gca ggc gag ctc gtg cgc acc gac agc ccc      485
 Asp Val Leu Ala Asp His Ala Gly Glu Leu Val Arg Thr Asp Ser Pro
              60                  65                  70

 aac ttc ctc tgc tcc gtg ctg ccc tcg cac tgg cgc tgc aac aag acg      533
 Asn Phe Leu Cys Ser Val Leu Pro Ser His Trp Arg Cys Asn Lys Thr
          75                  80                  85

 ctg ccc gtc gcc ttc aag gtg gtg gca ttg ggg gac gtg ccg gat ggt      581
 Leu Pro Val Ala Phe Lys Val Val Ala Leu Gly Asp Val Pro Asp Gly
      90                  95                 100

 acg gtg gtg act gtg atg gca ggc aat gac gag aac tac tcc gct gag      629
 Thr Val Val Thr Val Met Ala Gly Asn Asp Glu Asn Tyr Ser Ala Glu
 105                 110                 115                 120

 ctg cgc aat gcc tcg gcc gtc atg aag aac cag gtg gcc agg ttc aac      677
 Leu Arg Asn Ala Ser Ala Val Met Lys Asn Gln Val Ala Arg Phe Asn
                 125                 130                 135

 gac ctt cgc ttc gtg ggc cgc agc ggg cga ggc acc tcg gaa ctg aac      725
 Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Thr Ser Glu Leu Asn
             140                 145                 150

 cca ttc tcc gac ccc cgc cag ttt gac cgc tcc ttc ccc acg ctg cca      773
 Pro Phe Ser Asp Pro Arg Gln Phe Asp Arg Ser Phe Pro Thr Leu Pro
         155                 160                 165

 acc ctc acg gag agc cgc ttc cca gac ccc agg atg cat tat ccc ggg      821
 Thr Leu Thr Glu Ser Arg Phe Pro Asp Pro Arg Met His Tyr Pro Gly
     170                 175                 180

 gcc atg tca gct gcc ttc ccc tac agc gcc acg ccc tcg ggc acg agc      869
 Ala Met Ser Ala Ala Phe Pro Tyr Ser Ala Thr Pro Ser Gly Thr Ser
 185                 190                 195                 200

 atc agc agc ctc agc gtg gcg ggc atg ccg gcc acc agc cgc ttc cac      917
 Ile Ser Ser Leu Ser Val Ala Gly Met Pro Ala Thr Ser Arg Phe His
                 205                 210                 215

 cat acc tac ctc ccg cca ccc tac ccg ggg gcc ccg cag aac cag agc      965
 His Thr Tyr Leu Pro Pro Pro Tyr Pro Gly Ala Pro Gln Asn Gln Ser
             220                 225                 230

 ggg ccc ttc cag gcc aac ccg tcc ccc tac cac ctc tac tac ggg aca     1013
 Gly Pro Phe Gln Ala Asn Pro Ser Pro Tyr His Leu Tyr Tyr Gly Thr
         235                 240                 245

 tcc tct ggc tcc tac cag ttc tcc atg gtg gcc ggc agc agc agt ggg     1061
 Ser Ser Gly Ser Tyr Gln Phe Ser Met Val Ala Gly Ser Ser Ser Gly
     250                 255                 260

 ggc gac cgc tca cct acc cgc atg ctg gcc tct tgc acc agc agc gct     1109
 Gly Asp Arg Ser Pro Thr Arg Met Leu Ala Ser Cys Thr Ser Ser Ala
 265                 270                 275                 280

 gcc tct gtc gcc gcc ggc aac ctc atg aac ccc agc ctg ggc ggc cag     1157
 Ala Ser Val Ala Ala Gly Asn Leu Met Asn Pro Ser Leu Gly Gly Gln
                 285                 290                 295

 agt gat ggc gtg gag gcc gac ggc agc cac agc aac tca ccc acg gcc     1205
 Ser Asp Gly Val Glu Ala Asp Gly Ser His Ser Asn Ser Pro Thr Ala
             300                 305                 310

 ctg agc acg cca ggc cgc atg gat gag gcc gtg tgg cgg ccc tac tga     1253
 Leu Ser Thr Pro Gly Arg Met Asp Glu Ala Val Trp Arg Pro Tyr 
         315                 320                 325

 ccgccctggt ggactcctcc cgctggaggc ggggacccta acaaccttca agaccagtga   1313

 tgggccggct ccgaggctcc gggcgggaat gggacctgcg ctccagggtg gtctcggtcc   1373

 cagggtggtc ccagctggtg ggagcctctg gctgcatctg tgcagccaca tccttgtaca   1433

 gaggcatagg ttaccacccc caccccggcc cgggatactg cccccggccc agatcctggc   1493

 cgtctcatcc catacttctg tggggaatca gcctcctgcc acccccccgg aaggacctca   1553

 ctgtctccag ctatgcccag tgctgcatgg gacccatgtc tcctgggaca gaggccatct   1613

 ctcttccaga gagaggcagc attggcccac aggataagcc tcaggccctg ggaaacctcc   1673

 cgacccctgc accttcgttg gagcccctgc atcccctggg tccagccccc tctgcattta   1733

 cacagatttg agtcagaact ggaaagtgtc ccccaccccc accaccctcg agcggggttc   1793

 ccctcattgt acagatgggg caggacccag cacgctgctg gcagagatgg tttgagaaca   1853

 catccaagcc agtcccccca gcccagcttc ccctccgttc ctaactgttg gctttccccc   1913

 agccgcacgg tcccaggccc agagaagatg agtctatggc atcaggttct taaaccagga   1973

 aagcacctac agaccggctc ctccatgcac tttaccagct caacgcatcc actctctgtt   2033

 ctcttggcag ggcgggggag gggggatagg aggtcccctt tcccctaggt ggtctcataa   2093

 ttccatttgt ggagagaaca ggagggccag atagataggt cctagcagaa ggcattgagg   2153

 tgagggatca ttttgggtca gacatcaatg tccctgtccc ccctgggtcc agccaagctg   2213

 tgccccatcc cccaagcctc ctgggaggat ccagccaaat cttgcgactc ctggcacaca   2273

 cctgtctgta acctgttttg tgctctgaaa gcaaatagtc ctgagcaaaa aaaaaaaaaa   2333




      <210> 505
      <211> 1521
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (131)..(1474)

      <400> 505
 tttcgtacgg aagcggccaa gggggcggtg gcgcagagag gggtgcggag cgggcggaag     60

 aggcgtctgt gtcgcagctt ggtctcagag gagcatcgct gggaacaacg actatcgtct    120

 attccacaag   atg agt aac agc cac cct ctt cgc ccc ttt act gca gtg     169
              Met Ser Asn Ser His Pro Leu Arg Pro Phe Thr Ala Val
                1               5                  10

 ggg gaa att gat cat gtg cac att ttg tct gaa cat att ggt gcc ttg      217
 Gly Glu Ile Asp His Val His Ile Leu Ser Glu His Ile Gly Ala Leu
      15                  20                  25

 ttg att ggg gaa gaa tat ggc gac gtc aca ttc gtg gtg gaa aag aaa      265
 Leu Ile Gly Glu Glu Tyr Gly Asp Val Thr Phe Val Val Glu Lys Lys
  30                  35                  40                  45

 cgt ttt cct gcc cac agg gta att tta gca gcc agg tgc caa tat ttt      313
 Arg Phe Pro Ala His Arg Val Ile Leu Ala Ala Arg Cys Gln Tyr Phe
                  50                  55                  60

 cga gca tta tta tat ggt gga atg cga gag tct cag cct gaa gca gaa      361
 Arg Ala Leu Leu Tyr Gly Gly Met Arg Glu Ser Gln Pro Glu Ala Glu
              65                  70                  75

 att cct ctc caa gac acc act gca gaa gca ttc aca atg cta ctc aaa      409
 Ile Pro Leu Gln Asp Thr Thr Ala Glu Ala Phe Thr Met Leu Leu Lys
          80                  85                  90

 tat atc tac act ggg cgg gca acg ctg aca gat gag aag gag gag gtg      457
 Tyr Ile Tyr Thr Gly Arg Ala Thr Leu Thr Asp Glu Lys Glu Glu Val
      95                 100                 105

 ctg ctg gac ttt ttg agc ctg gct cat aaa tat gga ttt cca gag cta      505
 Leu Leu Asp Phe Leu Ser Leu Ala His Lys Tyr Gly Phe Pro Glu Leu
 110                 115                 120                 125

 gag gat tct acc tct gag tat ctc tgc acc ata ctt aac att cag aat      553
 Glu Asp Ser Thr Ser Glu Tyr Leu Cys Thr Ile Leu Asn Ile Gln Asn
                 130                 135                 140

 gtc tgc atg act ttt gat gtt gcc agt ctc tac tca ctt ccc aag tta      601
 Val Cys Met Thr Phe Asp Val Ala Ser Leu Tyr Ser Leu Pro Lys Leu
             145                 150                 155

 act tgt atg tgc tgc atg ttt atg gat agg aat gct cag gaa gtc ctc      649
 Thr Cys Met Cys Cys Met Phe Met Asp Arg Asn Ala Gln Glu Val Leu
         160                 165                 170

 tca agt gaa ggt ttc ctc tcc ctt tct aag aca gca ctt tta aac atc      697
 Ser Ser Glu Gly Phe Leu Ser Leu Ser Lys Thr Ala Leu Leu Asn Ile
     175                 180                 185

 gtg tta aga gac tca ttt gca gct ccc gaa aaa gat att ttc cta gcc      745
 Val Leu Arg Asp Ser Phe Ala Ala Pro Glu Lys Asp Ile Phe Leu Ala
 190                 195                 200                 205

 tta tta aac tgg tgt aag cac aat tca aag gag aat cat gct gaa atc      793
 Leu Leu Asn Trp Cys Lys His Asn Ser Lys Glu Asn His Ala Glu Ile
                 210                 215                 220

 atg cag gct gtg cgt tta cct ctc atg agc ctc aca gag ctt ctg aat      841
 Met Gln Ala Val Arg Leu Pro Leu Met Ser Leu Thr Glu Leu Leu Asn
             225                 230                 235

 gtt gtg agg cct tca gga ctg ctg tct cct gat gcc atc ctg gat gcc      889
 Val Val Arg Pro Ser Gly Leu Leu Ser Pro Asp Ala Ile Leu Asp Ala
         240                 245                 250

 att aaa gtg cga tct gag agc cgg gat atg gac ctc aat tat aga ggc      937
 Ile Lys Val Arg Ser Glu Ser Arg Asp Met Asp Leu Asn Tyr Arg Gly
     255                 260                 265

 atg ctc ata cca gaa gaa aac att gca act atg aag tat gga gcc caa      985
 Met Leu Ile Pro Glu Glu Asn Ile Ala Thr Met Lys Tyr Gly Ala Gln
 270                 275                 280                 285

 gtt gta aag ggg gag ctg aaa tca gcc tta tta gat ggt gat act caa     1033
 Val Val Lys Gly Glu Leu Lys Ser Ala Leu Leu Asp Gly Asp Thr Gln
                 290                 295                 300

 aat tat gat ttg gat cat gga ttt tca agg cac cca att gat gat gac     1081
 Asn Tyr Asp Leu Asp His Gly Phe Ser Arg His Pro Ile Asp Asp Asp
             305                 310                 315

 tgc cgt tcc ggc atc gag att aag cta ggt cag cca tcc att atc aat     1129
 Cys Arg Ser Gly Ile Glu Ile Lys Leu Gly Gln Pro Ser Ile Ile Asn
         320                 325                 330

 cac gta cgg ata ctc ttg tgg gac cga gat agc cgg tct tac tca tac     1177
 His Val Arg Ile Leu Leu Trp Asp Arg Asp Ser Arg Ser Tyr Ser Tyr
     335                 340                 345

 ttc att gaa gtg tca atg gat gaa ctt gat tgg gtc aga gtg ata gat     1225
 Phe Ile Glu Val Ser Met Asp Glu Leu Asp Trp Val Arg Val Ile Asp
 350                 355                 360                 365

 cat tca caa tat ctg tgt cgt tct tgg cag aaa tta tat ttt cca gcc     1273
 His Ser Gln Tyr Leu Cys Arg Ser Trp Gln Lys Leu Tyr Phe Pro Ala
                 370                 375                 380

 cgt gtc tgc agg tat att cga att gtt ggg act cac aac aca gtg aac     1321
 Arg Val Cys Arg Tyr Ile Arg Ile Val Gly Thr His Asn Thr Val Asn
             385                 390                 395

 aag att ttt cac att gtg gct ttt gaa tgt atg ttt aca aac aaa acc     1369
 Lys Ile Phe His Ile Val Ala Phe Glu Cys Met Phe Thr Asn Lys Thr
         400                 405                 410

 ttc act ctt gag aag ggg ctg ata ggt tac tac ttt ggg att gtg aca     1417
 Phe Thr Leu Glu Lys Gly Leu Ile Gly Tyr Tyr Phe Gly Ile Val Thr
     415                 420                 425

 ctc aaa gtg gac aca gtg gaa cac ctg gga gag aaa agg aaa aga ccc     1465
 Leu Lys Val Asp Thr Val Glu His Leu Gly Glu Lys Arg Lys Arg Pro
 430                 435                 440                 445

 cat gag tga agggtca gcatgcggcc ctggagttgc cgcaagttgg gatactgccc     1521
 His Glu 






      <210> 506
      <211> 3869
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (362)..(3826)

      <220>
      <221> misc_feature
      <222> (1)...(3869)
      <223> n = a,t,c or g

      <400> 506
 tgcatctcaa gtccaaaagg cagaaaatac acacgcggcg aagacacccg ggcagccgtg     60

 gaggctccgg cccgtccttg gtcgtcaatt acctcattgt ggatctgcca gggccaaggt    120

 ggccgaaatt gcctgggcgc tggtcggaga gagagccttt tgatcatctt gcgggggggg    180

 ggggaaagac tgattntttt tttttttcgt cgctctcggg atcgctcttc tgcctttatt    240

 ttattgtttt ggacattttt gagcgccggg gcttgaacgg tgctttttgt tcattcctgg    300

 gttttaatat tattttcctt cttcatccct ctctggccac tatggaattc taatttgaac    360

 c    atg ttt gga ttg aag ccg cct ctg tat tac tta cca ggg tcc tca     406
      Met Phe Gly Leu Lys Pro Pro Leu Tyr Tyr Leu Pro Gly Ser Ser
        1               5                  10                  15

 ctg agc agc gag tcg tcc ccc gtg tcc tct ccg gcc acc aac cac agc      454
 Leu Ser Ser Glu Ser Ser Pro Val Ser Ser Pro Ala Thr Asn His Ser
                  20                  25                  30

 tcc ccc gcc agc aca ccc aag cgc gtg ccc atg ggc cct atc atc gtc      502
 Ser Pro Ala Ser Thr Pro Lys Arg Val Pro Met Gly Pro Ile Ile Val
              35                  40                  45

 ccc cct ggg ggc cac agc gtg ccc agc acc ccc ccc gtg gtg acc atc      550
 Pro Pro Gly Gly His Ser Val Pro Ser Thr Pro Pro Val Val Thr Ile
          50                  55                  60

 gct cca acc aaa acc gtg aat ggt gtc tgg agg agt gag agc cgg cag      598
 Ala Pro Thr Lys Thr Val Asn Gly Val Trp Arg Ser Glu Ser Arg Gln
      65                  70                  75

 gat gcc ggt ccc agg agc agc agt gga ggt cgg gaa cgc ctc att gtg      646
 Asp Ala Gly Pro Arg Ser Ser Ser Gly Gly Arg Glu Arg Leu Ile Val
  80                  85                  90                  95

 gag ccc ccg ctc cct cag gag aag gca ggg gga cca gcc atc ccc tcg      694
 Glu Pro Pro Leu Pro Gln Glu Lys Ala Gly Gly Pro Ala Ile Pro Ser
                 100                 105                 110

 cac ctg ctc agc acc ccc tac ccc ttc ggc ctc tcc ccc agc tca gtt      742
 His Leu Leu Ser Thr Pro Tyr Pro Phe Gly Leu Ser Pro Ser Ser Val
             115                 120                 125

 gtg cag gat tcc cgc ttc ccg cca ctc aac ctc cag cgg ccc gtg cac      790
 Val Gln Asp Ser Arg Phe Pro Pro Leu Asn Leu Gln Arg Pro Val His
         130                 135                 140

 cac gtg gtg ccc ccc agt acc gtg acc gag gac tac ctg aga agc ttc      838
 His Val Val Pro Pro Ser Thr Val Thr Glu Asp Tyr Leu Arg Ser Phe
     145                 150                 155

 cgg ccc tac cac acc acc gac gac ctc cgc atg tcc tca ctg cct ccc      886
 Arg Pro Tyr His Thr Thr Asp Asp Leu Arg Met Ser Ser Leu Pro Pro
 160                 165                 170                 175

 ctc ggc ctg gac ccg gcc act gct gca gcc tac tac cac ccc agc tac      934
 Leu Gly Leu Asp Pro Ala Thr Ala Ala Ala Tyr Tyr His Pro Ser Tyr
                 180                 185                 190

 ctg gcc cca cac ccc ttc ccc cac ccg gcc ttc agg atg gac gac tcc      982
 Leu Ala Pro His Pro Phe Pro His Pro Ala Phe Arg Met Asp Asp Ser
             195                 200                 205

 tac tgc ctg tct gcc ctg agg tcc ccg ttc tac ccc atc ccc acc ccc     1030
 Tyr Cys Leu Ser Ala Leu Arg Ser Pro Phe Tyr Pro Ile Pro Thr Pro
         210                 215                 220

 ggc tcc ctg ccc cca ctg cac cca tca gcg atg cac ctg cac ctc tct     1078
 Gly Ser Leu Pro Pro Leu His Pro Ser Ala Met His Leu His Leu Ser
     225                 230                 235

 ggg gtc cgc tac cct ccc gag ctc tcc cac tca tcc ctg gca gcg ctg     1126
 Gly Val Arg Tyr Pro Pro Glu Leu Ser His Ser Ser Leu Ala Ala Leu
 240                 245                 250                 255

 cac tcg gag cgc atg tct ggc ctc agc gcg gag agg ctg cag atg gac     1174
 His Ser Glu Arg Met Ser Gly Leu Ser Ala Glu Arg Leu Gln Met Asp
                 260                 265                 270

 gag gag cta agg cgg gag agg gag cgc gag cgc gag cgc gag cgt gag     1222
 Glu Glu Leu Arg Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu
             275                 280                 285

 cgt gag gct gac cgc gag cgg gag aag gaa cgt gag cgc gaa cgc gag     1270
 Arg Glu Ala Asp Arg Glu Arg Glu Lys Glu Arg Glu Arg Glu Arg Glu
         290                 295                 300

 aag gag cgc gag caa gag aag gag cgt gag cgt gag aag gag cgc gag     1318
 Lys Glu Arg Glu Gln Glu Lys Glu Arg Glu Arg Glu Lys Glu Arg Glu
     305                 310                 315

 cgc gag ctg gag cgc cag cgg gag cag cgg gcc cgg gag aag gag ctg     1366
 Arg Glu Leu Glu Arg Gln Arg Glu Gln Arg Ala Arg Glu Lys Glu Leu
 320                 325                 330                 335

 ctg gcc gcc aag gcc ctg gag ccc agc ttc ctg ccc gtg gcc gag ctg     1414
 Leu Ala Ala Lys Ala Leu Glu Pro Ser Phe Leu Pro Val Ala Glu Leu
                 340                 345                 350

 cat ggg ctg cgt ggc cat gcc act gag gag cgg ggc aag ccc tcg gag     1462
 His Gly Leu Arg Gly His Ala Thr Glu Glu Arg Gly Lys Pro Ser Glu
             355                 360                 365

 cag ctg acc cca acc cga gca gag aag ctg aag gat gcc agc ctg cag     1510
 Gln Leu Thr Pro Thr Arg Ala Glu Lys Leu Lys Asp Ala Ser Leu Gln
         370                 375                 380

 gcg ccc aag ccc gtc caa cac ccc ttg cat ccg gtg ccc acc cca cac     1558
 Ala Pro Lys Pro Val Gln His Pro Leu His Pro Val Pro Thr Pro His
     385                 390                 395

 cac acg gtg ccc agc ctc atc tcc aac cat ggc atc ttc tct ctg cct     1606
 His Thr Val Pro Ser Leu Ile Ser Asn His Gly Ile Phe Ser Leu Pro
 400                 405                 410                 415

 agc agc agt gct gcc aca gcc ctg ctg atc cag cgc acc aat gag gag     1654
 Ser Ser Ser Ala Ala Thr Ala Leu Leu Ile Gln Arg Thr Asn Glu Glu
                 420                 425                 430

 gag aag tgg ctg gcg cgg cag cgg cgg ctg cgg cag gag aag gag gac     1702
 Glu Lys Trp Leu Ala Arg Gln Arg Arg Leu Arg Gln Glu Lys Glu Asp
             435                 440                 445

 cgg cag tct cag gtg tcc gag ttc cgg cag cag gtg ctg gag cag cac     1750
 Arg Gln Ser Gln Val Ser Glu Phe Arg Gln Gln Val Leu Glu Gln His
         450                 455                 460

 ctg gat atg ggc cgg ccc ccg gtg ccg gcg gag gca gag cac agg ccg     1798
 Leu Asp Met Gly Arg Pro Pro Val Pro Ala Glu Ala Glu His Arg Pro
     465                 470                 475

 gag agc acc acc agg cca gga cca aac cgt cac gag cca ggt ggc cgt     1846
 Glu Ser Thr Thr Arg Pro Gly Pro Asn Arg His Glu Pro Gly Gly Arg
 480                 485                 490                 495

 gac cct ccg cag cac ttt ggg ggg cca cca cct ctg att tcg ccc aag     1894
 Asp Pro Pro Gln His Phe Gly Gly Pro Pro Pro Leu Ile Ser Pro Lys
                 500                 505                 510

 ccc cag ctc cat gct gca ccc acg gcc ctc tgg aac ccc gtg tcc ctg     1942
 Pro Gln Leu His Ala Ala Pro Thr Ala Leu Trp Asn Pro Val Ser Leu
             515                 520                 525

 atg gac aac acc ttg gag acg cgg cgg gcc gaa agc cac tct ctg cac     1990
 Met Asp Asn Thr Leu Glu Thr Arg Arg Ala Glu Ser His Ser Leu His
         530                 535                 540

 agc cac ccg gct gca ttt gag ccc agc cgc cag gca gcc gtg ccg ctg     2038
 Ser His Pro Ala Ala Phe Glu Pro Ser Arg Gln Ala Ala Val Pro Leu
     545                 550                 555

 gtg aag gtg gag cgg gtc ttc tgc ccg gag aaa gca gag gag ggg cca     2086
 Val Lys Val Glu Arg Val Phe Cys Pro Glu Lys Ala Glu Glu Gly Pro
 560                 565                 570                 575

 cgg aag cgt gag cct gcc cct ctg gac aag tac cag cca cct ccg ccg     2134
 Arg Lys Arg Glu Pro Ala Pro Leu Asp Lys Tyr Gln Pro Pro Pro Pro
                 580                 585                 590

 cca cca cga gag gga ggg agc ctg gag cac cag ccc ttc ctg ccc ggg     2182
 Pro Pro Arg Glu Gly Gly Ser Leu Glu His Gln Pro Phe Leu Pro Gly
             595                 600                 605

 ccc ggg ccc ttc ctg gct gag ctc gag aag tcc acc cag acc atc ctg     2230
 Pro Gly Pro Phe Leu Ala Glu Leu Glu Lys Ser Thr Gln Thr Ile Leu
         610                 615                 620

 ggc cag cag cgg gcc tcc ctc cca cag gcg gcc acc ttc ggg gag ctc     2278
 Gly Gln Gln Arg Ala Ser Leu Pro Gln Ala Ala Thr Phe Gly Glu Leu
     625                 630                 635

 agc gga ccc ctg aag cct ggc tcg ccc tac cgg ccc cca gtg cca cgg     2326
 Ser Gly Pro Leu Lys Pro Gly Ser Pro Tyr Arg Pro Pro Val Pro Arg
 640                 645                 650                 655

 gcc ccc gac cct gcc tac atc tat gat gag ttt ctg cag cag cgc cgg     2374
 Ala Pro Asp Pro Ala Tyr Ile Tyr Asp Glu Phe Leu Gln Gln Arg Arg
                 660                 665                 670

 agg ctg gtc agc aag ctg gac ctg gag gag cgc agg cgg cgg gag gcc     2422
 Arg Leu Val Ser Lys Leu Asp Leu Glu Glu Arg Arg Arg Arg Glu Ala
             675                 680                 685

 cag gag aaa ggg tac tac tac gac ctc gat gac tct tac gac gag agc     2470
 Gln Glu Lys Gly Tyr Tyr Tyr Asp Leu Asp Asp Ser Tyr Asp Glu Ser
         690                 695                 700

 gat gag gag gag gtc agg gcc cac ctc cgt tgc gtg gcc gag cag ccg     2518
 Asp Glu Glu Glu Val Arg Ala His Leu Arg Cys Val Ala Glu Gln Pro
     705                 710                 715

 ccc ctc aaa ctg gac acg tcc tct gag aag cta gag ttt ttg caa ctt     2566
 Pro Leu Lys Leu Asp Thr Ser Ser Glu Lys Leu Glu Phe Leu Gln Leu
 720                 725                 730                 735

 ttt ggc ttg acc acc caa cag cag aag gag gaa ttg gtg gcc cag aag     2614
 Phe Gly Leu Thr Thr Gln Gln Gln Lys Glu Glu Leu Val Ala Gln Lys
                 740                 745                 750

 cgg agg aag cgg cgg agg atg ctg cga gag aga agc ccg tcg ccc cca     2662
 Arg Arg Lys Arg Arg Arg Met Leu Arg Glu Arg Ser Pro Ser Pro Pro
             755                 760                 765

 aca att cag agc aag cgg cag acg cct tca ccg aga ctg gcg ctg tct     2710
 Thr Ile Gln Ser Lys Arg Gln Thr Pro Ser Pro Arg Leu Ala Leu Ser
         770                 775                 780

 acc cgc tac agc cct gat gag atg aac aac agt ccc aac ttc gaa gaa     2758
 Thr Arg Tyr Ser Pro Asp Glu Met Asn Asn Ser Pro Asn Phe Glu Glu
     785                 790                 795

 aag aag aag ttc ctg acc atc ttc aac ctg acc cac atc agc gct gag     2806
 Lys Lys Lys Phe Leu Thr Ile Phe Asn Leu Thr His Ile Ser Ala Glu
 800                 805                 810                 815

 aag agg aaa gac aaa gag aga ctt gtt gaa atg ctc cgt gcc atg aag     2854
 Lys Arg Lys Asp Lys Glu Arg Leu Val Glu Met Leu Arg Ala Met Lys
                 820                 825                 830

 cag aag gca ctg tca gca gca gtg gcc gac tcc ttg aca aac tct ccg     2902
 Gln Lys Ala Leu Ser Ala Ala Val Ala Asp Ser Leu Thr Asn Ser Pro
             835                 840                 845

 agg gac agt cct gcc gtc tcc ctg agt gaa cca gcc acg cag caa gcc     2950
 Arg Asp Ser Pro Ala Val Ser Leu Ser Glu Pro Ala Thr Gln Gln Ala
         850                 855                 860

 tct ctg gat gtg gag aag ccg gtt ggt gtt gct gct tcc ttg tct gac     2998
 Ser Leu Asp Val Glu Lys Pro Val Gly Val Ala Ala Ser Leu Ser Asp
     865                 870                 875

 atc cca aag gcc gcg gag cct ggg aag ctg gaa cag gtc cgg ccc cag     3046
 Ile Pro Lys Ala Ala Glu Pro Gly Lys Leu Glu Gln Val Arg Pro Gln
 880                 885                 890                 895

 gag ctg tcg aga gtc cag gag cta gct cct gcc agc ggg gag aag gcc     3094
 Glu Leu Ser Arg Val Gln Glu Leu Ala Pro Ala Ser Gly Glu Lys Ala
                 900                 905                 910

 agg ctg agc gag gcc cct gga ggc aaa aag agt ctg agc atg ctt cac     3142
 Arg Leu Ser Glu Ala Pro Gly Gly Lys Lys Ser Leu Ser Met Leu His
             915                 920                 925

 tat atc cgg ggc gct gca ccc aag gac att cct gtg ccg ctg tcc cac     3190
 Tyr Ile Arg Gly Ala Ala Pro Lys Asp Ile Pro Val Pro Leu Ser His
         930                 935                 940

 agc acc aat ggg aag agc aag ccg tgg gag ccc ttt gtg gca gaa gag     3238
 Ser Thr Asn Gly Lys Ser Lys Pro Trp Glu Pro Phe Val Ala Glu Glu
     945                 950                 955

 ttt gca cat cag ttc cac gag tca gtg ctg cag tcc acc cag aag gcc     3286
 Phe Ala His Gln Phe His Glu Ser Val Leu Gln Ser Thr Gln Lys Ala
 960                 965                 970                 975

 ctg cag aag cat aaa ggg agc gtg gct gtg ctg tct gca gag cag aac     3334
 Leu Gln Lys His Lys Gly Ser Val Ala Val Leu Ser Ala Glu Gln Asn
                 980                 985                 990

 cac aag gtt gac acg tcc gtc cac tac aac att cct gag ctg cag tcc     3382
 His Lys Val Asp Thr Ser Val His Tyr Asn Ile Pro Glu Leu Gln Ser
             995                1000                1005

 tcc agc cgc gcc cct cca ccc cag cac aat ggg cag cag gag ccc ccc     3430
 Ser Ser Arg Ala Pro Pro Pro Gln His Asn Gly Gln Gln Glu Pro Pro
        1010                1015                1020

 act gca agg aag ggc ccc cca acc cag gag ttg gac cgg gac tcg gag     3478
 Thr Ala Arg Lys Gly Pro Pro Thr Gln Glu Leu Asp Arg Asp Ser Glu
    1025                1030                1035

 gag gag gaa gag gag gat gat gaa gat gga gaa gat gag gag gaa gtc     3526
 Glu Glu Glu Glu Glu Asp Asp Glu Asp Gly Glu Asp Glu Glu Glu Val
1040                1045                1050                1055

 ccc aag cgc aag tgg caa ggg atc gag gcc gtt ttt gaa gct tac cag     3574
 Pro Lys Arg Lys Trp Gln Gly Ile Glu Ala Val Phe Glu Ala Tyr Gln
                1060                1065                1070

 gaa cac ata gaa gag caa aat ctg gag cgg cag gtg tta cag aca caa     3622
 Glu His Ile Glu Glu Gln Asn Leu Glu Arg Gln Val Leu Gln Thr Gln
            1075                1080                1085

 tgt aga cga ctg gag gcc cgg cac tac agc ctc agc ctg acg gca gag     3670
 Cys Arg Arg Leu Glu Ala Arg His Tyr Ser Leu Ser Leu Thr Ala Glu
        1090                1095                1100

 cag ctc tcc cac agc gtg gcg gag ttg agg agc cag aaa cag aag atg     3718
 Gln Leu Ser His Ser Val Ala Glu Leu Arg Ser Gln Lys Gln Lys Met
    1105                1110                1115

 gtc tca gaa cgg gag cgg ctc cag gca gaa ctg gac cac tta cga aag     3766
 Val Ser Glu Arg Glu Arg Leu Gln Ala Glu Leu Asp His Leu Arg Lys
1120                1125                1130                1135

 tgc ctt gcc ttg cct gca atg cac tgg cct agg ggc tac ctg aag gga     3814
 Cys Leu Ala Leu Pro Ala Met His Trp Pro Arg Gly Tyr Leu Lys Gly
                1140                1145                1150

 tat ccc agg tga cgg tttcccttgc actaggccga acctatagta tagaaatatt     3869
 Tyr Pro Arg 






      <210> 507
      <211> 1906
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1519)..(1713)

      <220>
      <221> misc_feature
      <222> (1)...(1906)
      <223> n = a,t,c or g

      <400> 507
 atggaatcat cgaatggaat tnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     60

 nnnnnnnnnn nnnnnnnnnc atggaatgga attgaatgga atcatcatca catggaatca    120

 aatggaatca tcgaatggaa tcgaatgaaa tcatcatccc atggaatcaa atggaatcat    180

 catcacatgg aatcgaatgg aatcattatc gaatggtatc aaaaggaaac atcgaatgga    240

 attgaatgga ataaatctaa tggaatcgaa tggagtcatc atcaaatgga atcaaatgga    300

 atcattgaat ggaatcatca tagaatgaaa tcgaaaagaa tcatcgaatg gaatcgaatg    360

 caatcatcat caaatggaat tgaatggaat catcaaatgg aattgaatgg aatcatcatc    420

 aaatggaatc taatggaatc atctaatgga attaaattgg aatcatcatc aaatggaacc    480

 aaatggaatc atggaataga atcaaatgga ataatcatca aatggactcg aatggagtca    540

 acatcaaatg gaatcgaaca gaattatcaa atggaatcaa atagaatcat cgaatggact    600

 caaatggaat cctcaaatgg aatggaatgg aataatcaat gtactcaaat ggaatcatca    660

 ttgaatggaa tcgaatggaa tcatcgagtg gaatcgaatg taatcatcat caaatggaat    720

 caaaaataac catcatcaaa tggaatcaaa aataaccatc atcaattggt attgaatgga    780

 attctcatca aatggaattc aaaggaatca tcatcaaatg gaaccgaatg gaatcctcat    840

 tgaatggaaa tgaaaggggt catcatctaa tggaatcgca tggaatcatc atcaaatgga    900

 atcgaatgga atcaacatca aatggaatca aatggaatca ttgaacggaa ttgaatggaa    960

 tcgtcatcga atgaattgaa tgcaatcatc gaatggtctc gaatggaatc atcttcaaat   1020

 ggaatggaat ggaatcatcg catagaatcg aatggaatta tcatcgaatg gaatcgaatg   1080

 gaatcaacat caaacggaaa aaaacggaat tatcgaatgg aatcgaagag annnnnnnnn   1140

 nnnnnnnnnn nnnnnncatc taatggaatg gaatggaata atccacggac tcgaatgcaa   1200

 tcatcgtcga atggaatcga atggannnnn nnnnnnnnnn nnnnnnnnnn aatcattgaa   1260

 cggaatcgaa tggaatcatc atcggatgga aacgaatgga atcgtcatcg aatgaattga   1320

 aaggagtcat catcgaatgg tctcgcatgg aatcatcatc aaatggaatc gaatggaatc   1380

 aacatcaaat ggaatcaaat ggaatcattg aacggaattg aatggaatcg tcatcgaatg   1440

 aattgaatgc aatcatcgaa tggtctcgaa tggaatcatc ttcaaatgga atggaatgga   1500

 atcatcgcat agaatcga  atg gaa tta tca tcg aat gga atc gaa tgg tat    1551
                      Met Glu Leu Ser Ser Asn Gly Ile Glu Trp Tyr
                        1               5                  10

 caa ccc atc aaa cgg aaa aaa acg gaa tta tcg aat gga atc gaa gag     1599
 Gln Pro Ile Lys Arg Lys Lys Thr Glu Leu Ser Asn Gly Ile Glu Glu
              15                  20                  25

 aat cat cga atg gac tcg aat gga ata atc att gaa cgg aat cga atg     1647
 Asn His Arg Met Asp Ser Asn Gly Ile Ile Ile Glu Arg Asn Arg Met
          30                  35                  40

 gaa tca tca tcg gat gga aac gaa tgg aat cat cat cga atg gaa atg     1695
 Glu Ser Ser Ser Asp Gly Asn Glu Trp Asn His His Arg Met Glu Met
      45                  50                  55

 aaa gga gtc atc atc taa tggaat tgcatggaat catcataaaa tggaatcgaa     1749
 Lys Gly Val Ile Ile 
  60

 ttgaatcaac atcaaatgga atcaaatgga atcattgaac ggaattgaat ggaatcgtca   1809

 tcgaatgaat tgactgcaat catcgaatgg tctcgaatgg aatcatcttc aaatggaatg   1869

 gaatggaagt cgacgcggcc gcgaatttag tagtagt                            1906




      <210> 508
      <211> 964
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (670)..(891)

      <400> 508
 gttcaacatc ttgataaaag gagtttgcct gagaatggag actataatcc cagatccctg     60

 agggctagga gagcctgggt gggggcgctg acacttctgt gtgccctggt agagtagcca    120

 ccctgagaaa aaactgataa taaagtgacg agctgtaaat gatggctatg gggaaaacaa    180

 ctatttcaga gatttttctc attgctttgc aaagcgacct accctgagca gtatgggact    240

 cctccggatc atttttgaca tttgaatgtt ctttcctgac ccttggaaag gatatatgta    300

 tgtctttcaa atttatagta tcgaacatac aatttggggg ctggtaccaa gggttagata    360

 ttaagtttat taagtgcttg atgcaaaagt caaaggatgg catgggaggt aacctggttg    420

 gctgtgataa gtaaactcgt ggattttgaa gggggagcag tttctggttt gggtcgcagt    480

 ggccaagtaa gacccaccct cctcagacac tatcaagacc aagtccactg gcttttcatc    540

 cgtgttttca tccagtaacc aaataaccct gtccttgctg acccccaccc agctccattc    600

 ccactcaccc actcccaagg gccctctggt gaaccttcca ggctagctct ctgctccctc    660

 cttgccttc    atg gaa aac cag cta tcc tct gag agc cac ttc tgc agc     708
              Met Glu Asn Gln Leu Ser Ser Glu Ser His Phe Cys Ser
                1               5                  10

 ccc tcc aag tgg tgg ctt ttc ttc tca aac ctc aac ctc aca tat ctc      756
 Pro Ser Lys Trp Trp Leu Phe Phe Ser Asn Leu Asn Leu Thr Tyr Leu
      15                  20                  25

 atc ttc ccc agg ctg ggg agt cgg ggt cct cgt acc act gcc aga ctg      804
 Ile Phe Pro Arg Leu Gly Ser Arg Gly Pro Arg Thr Thr Ala Arg Leu
  30                  35                  40                  45

 ttc acc cag ttc aaa gaa aac cct gcc cgt tgc agg ctc atg cca ttc      852
 Phe Thr Gln Phe Lys Glu Asn Pro Ala Arg Cys Arg Leu Met Pro Phe
                  50                  55                  60

 tac tac atc cct ttc atc caa ttc ttt gtg ttc tac tga cttccccagc       901
 Tyr Tyr Ile Pro Phe Ile Gln Phe Phe Val Phe Tyr 
              65                  70

 gcttcctttg ggagaaggtg ccaattcttc aatagttgat tcctctctag aaatacaatg    961

 ttc                                                                  964




      <210> 509
      <211> 1065
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (643)..(870)

      <400> 509
 gacagtccca cacaaatcaa tttttaataa tttcaacttg ccaccagctc caaatccagc     60

 tgccttgggg atttatcacc agggaaaaca ctaaatgccc caggctgagc tatccatcca    120

 gtgatcagat gacccagcct gtgatctctt aagaacctac atctacacat ggcagcctgt    180

 tagtggcttc tctggaacta gtgcatagct gctcaatgtt agagccagaa ctctggttcc    240

 cagggagggc gagtatccca aagagatttg aggttaaatg gatggcagtc caggtggtcc    300

 cagacatgct ctcactgctg aattcctgca cttactccta gaatatacca gtgctgtttg    360

 ctcccgccat cctgagggct ttagaaagtg ctttaaaaag ggaggatctc gaagcagcag    420

 ctatttcaga ggcagctgtt gggaaagcct atagtggttc catggaggct atccaaggga    480

 ggaaccacaa gccaactccc cataagtcag gagatttgcc tgtggcccca cccagaatct    540

 gagcggacag aatggaggcc ttatgcatga tgctcacctg gcctgtttca gatggagggc    600

 accctacccc cagaaagttc tctccctccc aggcactaga cc   atg aca gga ata     654
                                                  Met Thr Gly Ile
                                                    1

 gat tcc tcc cca gag gaa att ctc agg cag gtt gga tgt aaa caa cag      702
 Asp Ser Ser Pro Glu Glu Ile Leu Arg Gln Val Gly Cys Lys Gln Gln
   5                  10                  15                  20

 cag ggt aag ggg gtg gaa cac gtg gag ggg agc tca gca gag gca gga      750
 Gln Gly Lys Gly Val Glu His Val Glu Gly Ser Ser Ala Glu Ala Gly
                  25                  30                  35

 gag gct gcc aga gga ggg ggg gct aag gga ggt ggg gga gct gct gga      798
 Glu Ala Ala Arg Gly Gly Gly Ala Lys Gly Gly Gly Gly Ala Ala Gly
              40                  45                  50

 aag gga acc agc aaa gta ggc acc ttg agg gct cca gaa agc ctg tca      846
 Lys Gly Thr Ser Lys Val Gly Thr Leu Arg Ala Pro Glu Ser Leu Ser
          55                  60                  65

 atg ttt att tca tac aca ccc taa agacagtaaa gcagattaga aattaaaagt     900
 Met Phe Ile Ser Tyr Thr Pro 
      70                  75

 taaggtggtg accctattgt gctgatgagt caaatgggcc agaagaaggg gaaagctaac    960

 ggtactcctg gtgccaaaac taaaattcaa aaggcggtga ctggacagca gagcactggg   1020

 cagattctca tctccagttt tcccagagaa gtcaattctg aattc                   1065




      <210> 510
      <211> 828
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (337)..(774)

      <220>
      <221> misc_feature
      <222> (1)...(828)
      <223> n = a,t,c or g

      <400> 510
 cttgaagttc aggacatgac tggacccaag tgctacccag gacaccatgc aaatactgag     60

 aagactgtta gctgctcatt tcttgaaccg tccatttcct cagaaacaga gttctcaagg    120

 acttggggat ctcaagacag aggacagggt tcanaagcta caggccattc ttaagccaat    180

 gatgctgaga agactcaaag aggatgttga aaaatactgg cacccaacaa ggnaacaatt    240

 attgaagtag agctgactaa tatccagaag aaatactatc gggctatttt ggagaagaat    300

 ttctccttcc tgtccaaagg ggcaggtcat accaac  atg cct aat cta ctt aac     354
                                          Met Pro Asn Leu Leu Asn
                                            1               5

 aca atg atg gag ttg cgc aag tgc tgc aac cac cca tat ctc atc aat      402
 Thr Met Met Glu Leu Arg Lys Cys Cys Asn His Pro Tyr Leu Ile Asn
              10                  15                  20

 ggt gct gaa gaa aaa atc cta aca gaa ttc cgt gaa gct tgc cat att      450
 Gly Ala Glu Glu Lys Ile Leu Thr Glu Phe Arg Glu Ala Cys His Ile
          25                  30                  35

 ata cct cat gac ttt cac ctg cag gcc atg gtt cgt tca gcc ggc aaa      498
 Ile Pro His Asp Phe His Leu Gln Ala Met Val Arg Ser Ala Gly Lys
      40                  45                  50

 ctg gtt ctt att gac aag ttg ctt cca aag ctt aaa gct ggt ggc cat      546
 Leu Val Leu Ile Asp Lys Leu Leu Pro Lys Leu Lys Ala Gly Gly His
  55                  60                  65                  70

 aaa gtt ctg atc ttc tct cag atg gta cgc tgc cta gac atc cta gag      594
 Lys Val Leu Ile Phe Ser Gln Met Val Arg Cys Leu Asp Ile Leu Glu
                  75                  80                  85

 gat tat tta atc cag agg agg tac tta tat gaa cgt att gat ggg cga      642
 Asp Tyr Leu Ile Gln Arg Arg Tyr Leu Tyr Glu Arg Ile Asp Gly Arg
              90                  95                 100

 gtt aga ggc aac ctt cga cag gct gcc att gac cgc ttc agc aag cct      690
 Val Arg Gly Asn Leu Arg Gln Ala Ala Ile Asp Arg Phe Ser Lys Pro
         105                 110                 115

 gac tca gac cgc ttt gtc ttc tta ctg tgt acc cgg gct ggt gga ctt      738
 Asp Ser Asp Arg Phe Val Phe Leu Leu Cys Thr Arg Ala Gly Gly Leu
     120                 125                 130

 ggt att aat ctt aca gct gct ggt gaa gat gca tga atag gtccaaccag      788
 Gly Ile Asn Leu Thr Ala Ala Gly Glu Asp Ala 
 135                 140                 145

 ctgtacattt ggaaaaataa aactttatta aaaaaaaaaa                          828




      <210> 511
      <211> 1772
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (6)..(1235)

      <400> 511
 atgct    atg gcc gaa ttc ggc ccg acg tcg cat gct ccc ggc cgc cat      47
          Met Ala Glu Phe Gly Pro Thr Ser His Ala Pro Gly Arg His
            1               5                  10

 ggc cgc ggg att tcc cgg gtc gac gat ttc gtc tca gtt caa tgt tac       95
 Gly Arg Gly Ile Ser Arg Val Asp Asp Phe Val Ser Val Gln Cys Tyr
  15                  20                  25                  30

 caa ttt ggg tgg tca cct aac ttt cca aca tgc aaa gga caa gta cga      143
 Gln Phe Gly Trp Ser Pro Asn Phe Pro Thr Cys Lys Gly Gln Val Arg
                  35                  40                  45

 tca tgt ggt cca cct cct caa ctc tcc aat ggt gaa gtt aag gag ata      191
 Ser Cys Gly Pro Pro Pro Gln Leu Ser Asn Gly Glu Val Lys Glu Ile
              50                  55                  60

 aga aaa gag gaa tat gga cac aat gaa gta gtg gaa tat gat tgc aat      239
 Arg Lys Glu Glu Tyr Gly His Asn Glu Val Val Glu Tyr Asp Cys Asn
          65                  70                  75

 cct aat ttt ata ata aac ggg cct aag aaa ata caa tgt gtg gat gga      287
 Pro Asn Phe Ile Ile Asn Gly Pro Lys Lys Ile Gln Cys Val Asp Gly
      80                  85                  90

 gaa tgg aca act tta ccc act tgt gtt gaa caa gtg aaa aca tgt gga      335
 Glu Trp Thr Thr Leu Pro Thr Cys Val Glu Gln Val Lys Thr Cys Gly
  95                 100                 105                 110

 tac ata cct gaa ctc gag tac ggt tat gtt cag ccg tct gtc cct ccc      383
 Tyr Ile Pro Glu Leu Glu Tyr Gly Tyr Val Gln Pro Ser Val Pro Pro
                 115                 120                 125

 tat caa cat gga gtt tca gtc gag gtg aat tgc aga aat gaa tat gca      431
 Tyr Gln His Gly Val Ser Val Glu Val Asn Cys Arg Asn Glu Tyr Ala
             130                 135                 140

 atg att gga aat aac atg att acc tgt att aat gga ata tgg aca gag      479
 Met Ile Gly Asn Asn Met Ile Thr Cys Ile Asn Gly Ile Trp Thr Glu
         145                 150                 155

 ctt cct atg tgt gtt gca aca cac caa ctt aag agg tgc aaa ata gca      527
 Leu Pro Met Cys Val Ala Thr His Gln Leu Lys Arg Cys Lys Ile Ala
     160                 165                 170

 gga gtt aat ata aaa aca tta ctc aag cta tct ggg aaa gaa ttt aat      575
 Gly Val Asn Ile Lys Thr Leu Leu Lys Leu Ser Gly Lys Glu Phe Asn
 175                 180                 185                 190

 cat aat tct aga ata cgt tac aga tgt tca gac atc ttc aga tac agg      623
 His Asn Ser Arg Ile Arg Tyr Arg Cys Ser Asp Ile Phe Arg Tyr Arg
                 195                 200                 205

 cac tca gtc tgt ata aac ggg aaa tgg aat cct gaa gta gac tgc aca      671
 His Ser Val Cys Ile Asn Gly Lys Trp Asn Pro Glu Val Asp Cys Thr
             210                 215                 220

 gaa aaa agg gaa caa ttc tgc cca ccg cca cct cag ata cct aat gct      719
 Glu Lys Arg Glu Gln Phe Cys Pro Pro Pro Pro Gln Ile Pro Asn Ala
         225                 230                 235

 cag aat atg aca acc aca gtg aat tat cag gat gga gaa aaa gta gct      767
 Gln Asn Met Thr Thr Thr Val Asn Tyr Gln Asp Gly Glu Lys Val Ala
     240                 245                 250

 gtt ctc tgt aaa gaa aac tat cta ctt cca gaa gca aaa gaa att gta      815
 Val Leu Cys Lys Glu Asn Tyr Leu Leu Pro Glu Ala Lys Glu Ile Val
 255                 260                 265                 270

 tgt aaa gat gga cga tgg caa tca tta cca cgc tgt gtt gag tct act      863
 Cys Lys Asp Gly Arg Trp Gln Ser Leu Pro Arg Cys Val Glu Ser Thr
                 275                 280                 285

 gca tat tgt ggg ccc cct cca tct att aac aat gga gat acc acc tca      911
 Ala Tyr Cys Gly Pro Pro Pro Ser Ile Asn Asn Gly Asp Thr Thr Ser
             290                 295                 300

 ttc cca tta tca gta tat cct cca ggg tca aca gtg acg tac cgt tgc      959
 Phe Pro Leu Ser Val Tyr Pro Pro Gly Ser Thr Val Thr Tyr Arg Cys
         305                 310                 315

 cag tcc ttc tat aaa ctc cag ggc tct gta act gta aca tgc aga aat     1007
 Gln Ser Phe Tyr Lys Leu Gln Gly Ser Val Thr Val Thr Cys Arg Asn
     320                 325                 330

 aaa cag tgg tca gaa cca cca aga tgc cta gat cca tgt gtg gta tct     1055
 Lys Gln Trp Ser Glu Pro Pro Arg Cys Leu Asp Pro Cys Val Val Ser
 335                 340                 345                 350

 gaa gaa aac atg aac aaa aat aac ata cag tta aaa tgg aga aac gat     1103
 Glu Glu Asn Met Asn Lys Asn Asn Ile Gln Leu Lys Trp Arg Asn Asp
                 355                 360                 365

 gga aaa ctc tat gca aaa aca ggg gat gct gtt gaa ttc cag tgt aaa     1151
 Gly Lys Leu Tyr Ala Lys Thr Gly Asp Ala Val Glu Phe Gln Cys Lys
             370                 375                 380

 ttc cca cat aaa gcg atg ata tca tca cca cca ttt cga gca atc tgt     1199
 Phe Pro His Lys Ala Met Ile Ser Ser Pro Pro Phe Arg Ala Ile Cys
         385                 390                 395

 cag gaa ggg aaa ttt gaa tat cct ata tgt gaa tga agca agcataattt     1249
 Gln Glu Gly Lys Phe Glu Tyr Pro Ile Cys Glu 
     400                 405

 tcctgaatat attcttcaaa catccatcta tgctaaaagt agccattatg tagccaattc   1309

 tgtagttact tcttttattc tttcaggtgt tgtttaactc agttttattt agaactctgg   1369

 atttttagag ctttagaaat ttgtaagctg agagaacaat gtttcactta ataggagggt   1429

 gtcttagtcc atattacatt gttataacag agtatcacag actggataac ttctaaccaa   1489

 tagtttattt gtttcataaa tctaaaagct gagaagtcca agatggtggg gctgcctctg   1549

 gtgagggtct tctcgaagca tcataatatg ctggaaggca tcacaacatg gtggaaggga   1609

 tcacgtggca aaagagcatg tacatgggag tgagagaaaa agagagagag agacagagtg   1669

 gcgggggcgg ggaggagcgc aaactcatcc tttataaaga caccactcct gagataacaa   1729

 tccaatccca tgataatgac attaatccat tcaagaagat aga                     1772




      <210> 512
      <211> 376
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (13)..(264)

      <400> 512
 cgaaccagct ct    atg acc aca tct ccc ata acc agc ccc ggc ctg caa      48
                  Met Thr Thr Ser Pro Ile Thr Ser Pro Gly Leu Gln
                    1               5                  10

 agg cag cca cca cag agc ttc tta gtg atg tat cag cgc att cct gat       96
 Arg Gln Pro Pro Gln Ser Phe Leu Val Met Tyr Gln Arg Ile Pro Asp
          15                  20                  25

 gga cgg tgt gtt act tgg tgt tcc att ctc cca gtg aaa cat aat tct      144
 Gly Arg Cys Val Thr Trp Cys Ser Ile Leu Pro Val Lys His Asn Ser
      30                  35                  40

 ctg tca atg gaa gca ttt gag aaa aaa aca cct ttc aaa gtg aaa ctg      192
 Leu Ser Met Glu Ala Phe Glu Lys Lys Thr Pro Phe Lys Val Lys Leu
  45                  50                  55                  60

 tat tat gtt act gga aca ttt gtt aaa aat cta tta acc tct aag aag      240
 Tyr Tyr Val Thr Gly Thr Phe Val Lys Asn Leu Leu Thr Ser Lys Lys
                  65                  70                  75

 cca aga aca gaa att cag caa taa aaggtaaacg tactctcaga aaccacctct     294
 Pro Arg Thr Glu Ile Gln Gln 
              80

 ggcctgaaaa ggggccgact gaaacatata cctatttgaa gatccctggc acacagatac    354

 agcagaagaa gcccaaatgt tg                                             376




      <210> 513
      <211> 928
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (47)..(928)

      <400> 513
 cagatctgga cttcaacaac actgactggg cctatggggt gatccg   atg aaa tct      55
                                                      Met Lys Ser
                                                        1

 ctt gca gag cag atg cgt aac cac gac cgc gag cag atg agc cgc atg      103
 Leu Ala Glu Gln Met Arg Asn His Asp Arg Glu Gln Met Ser Arg Met
       5                  10                  15

 gcc cat aac ctg cca gag cag tac cag gag tgc gcg ccg gtc gag cag      151
 Ala His Asn Leu Pro Glu Gln Tyr Gln Glu Cys Ala Pro Val Glu Gln
  20                  25                  30                  35

 gtg gcg cag gta ttc aac aag ctg ttc aac gag ctg cgc gcc gcg ttc      199
 Val Ala Gln Val Phe Asn Lys Leu Phe Asn Glu Leu Arg Ala Ala Phe
                  40                  45                  50

 ccg gcc agc atg gcg aac ttc cgc acc cag gaa gac ctg aac gaa ttc      247
 Pro Ala Ser Met Ala Asn Phe Arg Thr Gln Glu Asp Leu Asn Glu Phe
              55                  60                  65

 cgc cgt cag tgg ctg ctg gcg ttt cag gag aac ggg atc cac acc atg      295
 Arg Arg Gln Trp Leu Leu Ala Phe Gln Glu Asn Gly Ile His Thr Met
          70                  75                  80

 gct cag gtc gat gcc ggc atg cgc att gcc cgc cgc cag gag cgc cca      343
 Ala Gln Val Asp Ala Gly Met Arg Ile Ala Arg Arg Gln Glu Arg Pro
      85                  90                  95

 ttc ctg ccg tcg ccg ggc cag ttc gtc gcc tgg tgc aag cag agc ggc      391
 Phe Leu Pro Ser Pro Gly Gln Phe Val Ala Trp Cys Lys Gln Ser Gly
 100                 105                 110                 115

 ggc gcg ctg ggc gtc aac gtt gac cag gtg atc gcc gag tac tgg gaa      439
 Gly Ala Leu Gly Val Asn Val Asp Gln Val Ile Ala Glu Tyr Trp Glu
                 120                 125                 130

 tgg cgt aat cgt tcg ttc gaa ttc atc tcc agc gag caa ttt cca tgg      487
 Trp Arg Asn Arg Ser Phe Glu Phe Ile Ser Ser Glu Gln Phe Pro Trp
             135                 140                 145

 tcg cag ccg gtc atg tac cac att tgc gta gaa ttg cgc cac cgc agc      535
 Ser Gln Pro Val Met Tyr His Ile Cys Val Glu Leu Arg His Arg Ser
         150                 155                 160

 acc gag cgc cag tta acg cat ggt gaa ctg gca cgc gag gca ggc gat      583
 Thr Glu Arg Gln Leu Thr His Gly Glu Leu Ala Arg Glu Ala Gly Asp
     165                 170                 175

 ctg ctg gac atg tgg gaa agg cgc gtc acc gag ggt aag cca gtg ccg      631
 Leu Leu Asp Met Trp Glu Arg Arg Val Thr Glu Gly Lys Pro Val Pro
 180                 185                 190                 195

 ccg gta cgc cgg gct att gcc gca cca gct gcc gag caa ggg ccg acg      679
 Pro Val Arg Arg Ala Ile Ala Ala Pro Ala Ala Glu Gln Gly Pro Thr
                 200                 205                 210

 ccg atc cag ctg ctg ctg gcc aag tac aac cgc aac aag tcg aac ggg      727
 Pro Ile Gln Leu Leu Leu Ala Lys Tyr Asn Arg Asn Lys Ser Asn Gly
             215                 220                 225

 atg act atc gcg gag ctt gaa gaa gag cga gat gct acg cca ggc gca      775
 Met Thr Ile Ala Glu Leu Glu Glu Glu Arg Asp Ala Thr Pro Gly Ala
         230                 235                 240

 gtg aac gaa gac gcg gcg atg gcg ctc gct gcg atg aag cta gcg ctg      823
 Val Asn Glu Asp Ala Ala Met Ala Leu Ala Ala Met Lys Leu Ala Leu
     245                 250                 255

 gca tcg ctc gaa gcg gag cct gtg gcg tgg cta ctg tca ggc ggc ggc      871
 Ala Ser Leu Glu Ala Glu Pro Val Ala Trp Leu Leu Ser Gly Gly Gly
 260                 265                 270                 275

 gca aaa aac aac gtc agc ttc gat agt ggc aat gct tat gcc gcc cag      919
 Ala Lys Asn Asn Val Ser Phe Asp Ser Gly Asn Ala Tyr Ala Ala Gln
                 280                 285                 290

 ctg cga gaa                                                          928
 Leu Arg Glu 






      <210> 514
      <211> 1262
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (122)..(970)

      <220>
      <221> misc_feature
      <222> (1)...(1262)
      <223> n = a,t,c or g

      <400> 514
 tggtcatggc gagccanctt tgatncccct tttgtatagc gagtacccag ctggctagcg     60

 tttaaactta agcttggtac cgagctcgga tccactagtc cagtgtggtg gaattcgcag    120

 c    atg ggg ccc ctg ccg cgc acc gtg gag ctc ttc tat gac gtg ctg     166
      Met Gly Pro Leu Pro Arg Thr Val Glu Leu Phe Tyr Asp Val Leu
        1               5                  10                  15

 tcc ccc tac tcc tgg ctg ggc ttc gag atc ctg tgc cgg tat cag aat      214
 Ser Pro Tyr Ser Trp Leu Gly Phe Glu Ile Leu Cys Arg Tyr Gln Asn
                  20                  25                  30

 atc tgg aac atc aac ctg cag ttg cgg ccc agc ctc ata aca ggg atc      262
 Ile Trp Asn Ile Asn Leu Gln Leu Arg Pro Ser Leu Ile Thr Gly Ile
              35                  40                  45

 atg aaa gac agt gga aac aag cct cca ggt ctg ctt ccc cgc aaa gga      310
 Met Lys Asp Ser Gly Asn Lys Pro Pro Gly Leu Leu Pro Arg Lys Gly
          50                  55                  60

 cta tac atg gca aat gac tta aag ctc ctg aga cac cat ctc cag att      358
 Leu Tyr Met Ala Asn Asp Leu Lys Leu Leu Arg His His Leu Gln Ile
      65                  70                  75

 ccc atc cac ttc ccc aag gat ttc ttg tct gtg atg ctt gaa aaa gga      406
 Pro Ile His Phe Pro Lys Asp Phe Leu Ser Val Met Leu Glu Lys Gly
  80                  85                  90                  95

 agt ttg tct gcc atg cgt ttc ctc acc gcc gtg aac ttg gag cat cca      454
 Ser Leu Ser Ala Met Arg Phe Leu Thr Ala Val Asn Leu Glu His Pro
                 100                 105                 110

 gag atg ctg gag aaa gcg tcc cgg gag ctg tgg atg cgc gtc tgg tca      502
 Glu Met Leu Glu Lys Ala Ser Arg Glu Leu Trp Met Arg Val Trp Ser
             115                 120                 125

 agg gtg agt gtg ggg ctc tgg gaa tcc tct ggg agg acc ttg gat gac      550
 Arg Val Ser Val Gly Leu Trp Glu Ser Ser Gly Arg Thr Leu Asp Asp
         130                 135                 140

 ttt ctg acc ttc ccc agg cac gtt ttc agg gtc atg atc ctg ccc ccg      598
 Phe Leu Thr Phe Pro Arg His Val Phe Arg Val Met Ile Leu Pro Pro
     145                 150                 155

 ccc ggg gac tct act gtc ctc cca gtc aca ccc ctc tcc ccg cac cgc      646
 Pro Gly Asp Ser Thr Val Leu Pro Val Thr Pro Leu Ser Pro His Arg
 160                 165                 170                 175

 ctt cct gct gtc ttc tct tct tcc cag aat gaa gac atc acc gag ccg      694
 Leu Pro Ala Val Phe Ser Ser Ser Gln Asn Glu Asp Ile Thr Glu Pro
                 180                 185                 190

 cag agc atc ctg gcg gct gca gag aag gct ggt atg tct gca gaa caa      742
 Gln Ser Ile Leu Ala Ala Ala Glu Lys Ala Gly Met Ser Ala Glu Gln
             195                 200                 205

 gcc cag gga ctt ctg gaa aag atc gca acg cca aag gtg aag aac cag      790
 Ala Gln Gly Leu Leu Glu Lys Ile Ala Thr Pro Lys Val Lys Asn Gln
         210                 215                 220

 ctc aag gag acc act gag gca gcc tgc aga tac gga gcc ttt ggg ctg      838
 Leu Lys Glu Thr Thr Glu Ala Ala Cys Arg Tyr Gly Ala Phe Gly Leu
     225                 230                 235

 ccc atc acc gtg gcc cat gtg gat ggc caa acc cac atg tta ttt ggc      886
 Pro Ile Thr Val Ala His Val Asp Gly Gln Thr His Met Leu Phe Gly
 240                 245                 250                 255

 tct gac cgg atg gag ctg ctg gcg cac ctg ctg gga gag aag tgg atg      934
 Ser Asp Arg Met Glu Leu Leu Ala His Leu Leu Gly Glu Lys Trp Met
                 260                 265                 270

 ggc cct ata cct cca gcc gtg aat gcc aga ctt taa gatt gcccggagga      984
 Gly Pro Ile Pro Pro Ala Val Asn Ala Arg Leu 
             275                 280

 agcaaactct tcgtataaaa aaagcaggcc atctgcttaa cccttggctc caccataagg   1044

 cactgggact cggatttctc tatctgatag aggtattttc tgtggccctg ggagctgtct   1104

 gtctttcccc tacccccaag gatgccagga agacgtccac cattagccat gtggcaacct   1164

 ttacttctat gcctcacaag tgcctttcag agagccccaa ttctgctttc ccacaaaata   1224

 aacctaatgc catcaggcaa aacattaaaa aaaaaaaa                           1262




      <210> 515
      <211> 1058
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (122)..(766)

      <220>
      <221> misc_feature
      <222> (1)...(1058)
      <223> n = a,t,c or g

      <400> 515
 tggtcatggc gagccanctt tgatncccct tttgtatagc gagtacccag ctggctagcg     60

 tttaaactta agcttggtac cgagctcgga tccactagtc cagtgtggtg gaattcgcag    120

 c    atg ggg ccc ctg ccg cgc acc gtg gag ctc ttc tat gac gtg ctg     166
      Met Gly Pro Leu Pro Arg Thr Val Glu Leu Phe Tyr Asp Val Leu
        1               5                  10                  15

 tcc ccc tac tcc tgg ctg ggc ttc gag atc ctg tgc cgg tat cag aat      214
 Ser Pro Tyr Ser Trp Leu Gly Phe Glu Ile Leu Cys Arg Tyr Gln Asn
                  20                  25                  30

 atc tgg aac atc aac ctg cag ttg cgg ccc agc ctc ata aca ggg atc      262
 Ile Trp Asn Ile Asn Leu Gln Leu Arg Pro Ser Leu Ile Thr Gly Ile
              35                  40                  45

 atg aaa gac agt gga aac aag cct cca ggt ctg ctt ccc cgc aaa gga      310
 Met Lys Asp Ser Gly Asn Lys Pro Pro Gly Leu Leu Pro Arg Lys Gly
          50                  55                  60

 cta tac atg gca aat gac tta aag ctc ctg aga cac cat ctc cag att      358
 Leu Tyr Met Ala Asn Asp Leu Lys Leu Leu Arg His His Leu Gln Ile
      65                  70                  75

 ccc atc cac ttc ccc aag gat ttc ttg tct gtg atg ctt gaa aaa gga      406
 Pro Ile His Phe Pro Lys Asp Phe Leu Ser Val Met Leu Glu Lys Gly
  80                  85                  90                  95

 agt ttg tct gcc atg cgt ttc ctc acc gcc gtg aac ttg gag cat cca      454
 Ser Leu Ser Ala Met Arg Phe Leu Thr Ala Val Asn Leu Glu His Pro
                 100                 105                 110

 gag atg ctg gag aaa gcg tcc cgg gag ctg tgg atg cgc gtc tgg tca      502
 Glu Met Leu Glu Lys Ala Ser Arg Glu Leu Trp Met Arg Val Trp Ser
             115                 120                 125

 agg gct gca gag aag gct ggt atg tct gca gaa caa gcc cag gga ctt      550
 Arg Ala Ala Glu Lys Ala Gly Met Ser Ala Glu Gln Ala Gln Gly Leu
         130                 135                 140

 ctg gaa aag atc gca acg cca aag gtg aag aac cag ctc aag gag acc      598
 Leu Glu Lys Ile Ala Thr Pro Lys Val Lys Asn Gln Leu Lys Glu Thr
     145                 150                 155

 act gag gca gcc tgc aga tac gga gcc ttt ggg ctg ccc atc acc gtg      646
 Thr Glu Ala Ala Cys Arg Tyr Gly Ala Phe Gly Leu Pro Ile Thr Val
 160                 165                 170                 175

 gcc cat gtg gat ggc caa acc cac atg tta ttt ggc tct gac cgg atg      694
 Ala His Val Asp Gly Gln Thr His Met Leu Phe Gly Ser Asp Arg Met
                 180                 185                 190

 gag ctg ctg gcg cac ctg ctg gga gag aag tgg atg ggc cct ata cct      742
 Glu Leu Leu Ala His Leu Leu Gly Glu Lys Trp Met Gly Pro Ile Pro
             195                 200                 205

 cca gcc gtg aat gcc aga ctt taa gattgcccgg aggaagcaaa ctcttcgtat     796
 Pro Ala Val Asn Ala Arg Leu 
         210

 aaaaaaagca ggccatctgc ttaacccttg gctccaccat aaggcactgg gactcggatt    856

 tctctatctg atagaggtat tttctgtggc cctgggagct gtctgtcttt cccctacccc    916

 caaggatgcc aggaagacgt ccaccattag ccatgtggca acctttactt ctatgcctca    976

 caagtgcctt tcagagagcc ccaattctgc tttcccacaa aataaaccta atgccatcag   1036

 gcaaaacatt aaaaaaaaaa aa                                            1058




      <210> 516
      <211> 426
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (133)..(417)

      <400> 516
 gtggatttaa gagagcacag cccggaggcg tgtctgggct aaccctggtc ctcctggatc     60

 gacgccgcca aattacactg ctccgacaat ttagaagagg ctggaaaaga gggtggaaaa    120

 agcagggagg tt    atg agg ctt aat aaa gaa gat atg cac tta ttt ggc     168
                  Met Arg Leu Asn Lys Glu Asp Met His Leu Phe Gly
                    1               5                  10

 cat tac cca gca cat gac gac ttc tat ctc gta gtg tgc agt gcc tgt      216
 His Tyr Pro Ala His Asp Asp Phe Tyr Leu Val Val Cys Ser Ala Cys
          15                  20                  25

 aac cag gtc gtc aag cca cag gtt ttc cag tcg cac tgc ggt aag tgg      264
 Asn Gln Val Val Lys Pro Gln Val Phe Gln Ser His Cys Gly Lys Trp
      30                  35                  40

 acc cct gca ccg tcg gcc aca tct gca gct gcc gcc ctg ggg aca gtc      312
 Thr Pro Ala Pro Ser Ala Thr Ser Ala Ala Ala Ala Leu Gly Thr Val
  45                  50                  55                  60

 gcc ttc ccc tgg gct ccc cga cag ggt ctc gcc atg tct tgt ctc agc      360
 Ala Phe Pro Trp Ala Pro Arg Gln Gly Leu Ala Met Ser Cys Leu Ser
                  65                  70                  75

 ctg agg ctg tgg gta aag tct tcc tgg gct gct gcc tct gct cgc agg      408
 Leu Arg Leu Trp Val Lys Ser Ser Trp Ala Ala Ala Ser Ala Arg Arg
              80                  85                  90

 ctg ttt taa gagctgtac                                                426
 Leu Phe 






      <210> 517
      <211> 3523
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (562)..(3523)

      <400> 517
 ccagagggaa gggagaacca ccctgatgtt cacagtgggg tgggcggtta gcaagagtca     60

 agctggtttc tccggggaag cgggtgccta tttgaaggcg agtaaagacg taggagaccg    120

 aggaaagtgt gtgggaggcg ttgacctgcc ccttgtcctg gccccgccac tgcccacttc    180

 agcttctgcc ggaccctcct ggagcacacg gtgtcagctg agagcatccc ctgccacttg    240

 cctcggacac ctggcaccag cctcacgtgg catgactccc gcagccagag ggcggccagc    300

 agcaggccaa tcaagctcct gcagcagccc ggcacagaca ccccccaggg ccggctgtac    360

 tctgaccact atggcctgta ccatacaagc ccctcgctgg gtggcctgac ccggcccgtg    420

 gtcctgtgga gtcagcagga cgtctgcaag tggctcaaga agcactgtcc ccacaactac    480

 ctcgtctacg tggaggcctt ctcccagcat gccatcaccg gccgggcact gctgcggctg    540

 aatgcggaga agctgcagcg g  atg ggg ctg gcc cag gag gcc cag agg cag     591
                          Met Gly Leu Ala Gln Glu Ala Gln Arg Gln
                            1               5                  10

 gag gtg ctg cag cag gtg ctc cgc ctg cag gtg cgt gag gag ggg cgg      639
 Glu Val Leu Gln Gln Val Leu Arg Leu Gln Val Arg Glu Glu Gly Arg
                  15                  20                  25

 agc ctg cag ctg ctc agc caa gaa aca cat ggg aca cgg cac atc ccc      687
 Ser Leu Gln Leu Leu Ser Gln Glu Thr His Gly Thr Arg His Ile Pro
              30                  35                  40

 ggt gca cac aaa cac act gta ttc cac gac acc ctg gca tgt aga tgc      735
 Gly Ala His Lys His Thr Val Phe His Asp Thr Leu Ala Cys Arg Cys
          45                  50                  55

 tca cag aaa aca gcc gtc cct cac cag cac cct gac act gag aca tgc      783
 Ser Gln Lys Thr Ala Val Pro His Gln His Pro Asp Thr Glu Thr Cys
      60                  65                  70

 cgc agc ctg gac aca tgg ata ctg aaa tcc aga cac atc gtc ccc agt      831
 Arg Ser Leu Asp Thr Trp Ile Leu Lys Ser Arg His Ile Val Pro Ser
  75                  80                  85                  90

 cct gtg ctg tca gtg ccc cgc cac ctc cag acc act cag ccc aca ccg      879
 Pro Val Leu Ser Val Pro Arg His Leu Gln Thr Thr Gln Pro Thr Pro
                  95                 100                 105

 gac ccc agt gcc ccc tgc ctg cag aag ccc aag ctg tgg ggc aga gaa      927
 Asp Pro Ser Ala Pro Cys Leu Gln Lys Pro Lys Leu Trp Gly Arg Glu
             110                 115                 120

 ggc cct ggc act ggt tca gaa cca ctg ccc cca gag ctg gga aag ggt      975
 Gly Pro Gly Thr Gly Ser Glu Pro Leu Pro Pro Glu Leu Gly Lys Gly
         125                 130                 135

 gac cca atg gag tgc atc acc ttc ggc atc atc ttc gca gct gtg ggg     1023
 Asp Pro Met Glu Cys Ile Thr Phe Gly Ile Ile Phe Ala Ala Val Gly
     140                 145                 150

 cta cgc aca ctg tgg agc tgc gta cac tgt aga gct gcg tgt tgg gaa     1071
 Leu Arg Thr Leu Trp Ser Cys Val His Cys Arg Ala Ala Cys Trp Glu
 155                 160                 165                 170

 ggg ggt ctg gaa gtt gag atg acg gat cct ttc tgc gtt gga ggc cgt     1119
 Gly Gly Leu Glu Val Glu Met Thr Asp Pro Phe Cys Val Gly Gly Arg
                 175                 180                 185

 cgg ctc ccg ggg tcc agc aag agt ggt ccc ggg aag gat ggc agc cga     1167
 Arg Leu Pro Gly Ser Ser Lys Ser Gly Pro Gly Lys Asp Gly Ser Arg
             190                 195                 200

 aag gag gtc cga ctt cca atg ctg cat gac cca ccg aag atg ggg atg     1215
 Lys Glu Val Arg Leu Pro Met Leu His Asp Pro Pro Lys Met Gly Met
         205                 210                 215

 ccg gtg gtc cgt ggt gga cag aca gtg ccc ggc cag gcc cct ctc tgc     1263
 Pro Val Val Arg Gly Gly Gln Thr Val Pro Gly Gln Ala Pro Leu Cys
     220                 225                 230

 ttt gac ccg gga agt cca gcc agt gac aag aca gaa ggg aag aaa aag     1311
 Phe Asp Pro Gly Ser Pro Ala Ser Asp Lys Thr Glu Gly Lys Lys Lys
 235                 240                 245                 250

 ggg cgg cca aaa gcc gag aac cag gcc ctc cga gac att cct ctc tcc     1359
 Gly Arg Pro Lys Ala Glu Asn Gln Ala Leu Arg Asp Ile Pro Leu Ser
                 255                 260                 265

 ctg atg aac gac tgg aag gat gag ttc aag gca cac tcg agg gtg aag     1407
 Leu Met Asn Asp Trp Lys Asp Glu Phe Lys Ala His Ser Arg Val Lys
             270                 275                 280

 tgt cca aac tca ggg tgc tgg ctg gag ttc ccc agc atc tac ggg ctc     1455
 Cys Pro Asn Ser Gly Cys Trp Leu Glu Phe Pro Ser Ile Tyr Gly Leu
         285                 290                 295

 aag tac cat tac cag cgg tgc caa ggg ggt gcc atc tca gat cgc ctg     1503
 Lys Tyr His Tyr Gln Arg Cys Gln Gly Gly Ala Ile Ser Asp Arg Leu
     300                 305                 310

 gcc ttc ccc tgc ccc ttc tgc gag gcc gca ttc acc tct aag acc cag     1551
 Ala Phe Pro Cys Pro Phe Cys Glu Ala Ala Phe Thr Ser Lys Thr Gln
 315                 320                 325                 330

 ctg gag aaa cac cgg atc tgg aac cac atg gac cga ccc ctg cct gcc     1599
 Leu Glu Lys His Arg Ile Trp Asn His Met Asp Arg Pro Leu Pro Ala
                 335                 340                 345

 tcc aag cct ggg ccc atc agc agg ccg gtc acc atc agc cgg cct gtt     1647
 Ser Lys Pro Gly Pro Ile Ser Arg Pro Val Thr Ile Ser Arg Pro Val
             350                 355                 360

 ggg gtc agc aag ccc atc gga gtg agc aaa cct gtc act att ggc aaa     1695
 Gly Val Ser Lys Pro Ile Gly Val Ser Lys Pro Val Thr Ile Gly Lys
         365                 370                 375

 cct gtg ggt gtc agc aaa ccc att ggc atc agc aag cca gtc tcg gtc     1743
 Pro Val Gly Val Ser Lys Pro Ile Gly Ile Ser Lys Pro Val Ser Val
     380                 385                 390

 ggc aga ccc atg cca gtc acc aag gcc atc ccg gtc act agg ccc gtg     1791
 Gly Arg Pro Met Pro Val Thr Lys Ala Ile Pro Val Thr Arg Pro Val
 395                 400                 405                 410

 cca gtc acc aaa cct gtc aca gtc agc agg ccc atg ccc gtc acc aag     1839
 Pro Val Thr Lys Pro Val Thr Val Ser Arg Pro Met Pro Val Thr Lys
                 415                 420                 425

 gcc atg ccg gtc acc aaa ccc atc aca gtc acc aag tct gtg ccg gtc     1887
 Ala Met Pro Val Thr Lys Pro Ile Thr Val Thr Lys Ser Val Pro Val
             430                 435                 440

 acc aaa ccc gta cct gtc acc aaa ccc att acg gta aca aag ctt gtg     1935
 Thr Lys Pro Val Pro Val Thr Lys Pro Ile Thr Val Thr Lys Leu Val
         445                 450                 455

 aca gtt acg aaa ccc gtg ccg gtc acc aag cca gtg aca gtc agc agg     1983
 Thr Val Thr Lys Pro Val Pro Val Thr Lys Pro Val Thr Val Ser Arg
     460                 465                 470

 ccc att gtg gtc agc aag ccg gtg aca gtc agc agg ccc att gct atc     2031
 Pro Ile Val Val Ser Lys Pro Val Thr Val Ser Arg Pro Ile Ala Ile
 475                 480                 485                 490

 agc aga cac aca ccg ccc tgc aaa atg gtg ctg ctg acc agg tcg gag     2079
 Ser Arg His Thr Pro Pro Cys Lys Met Val Leu Leu Thr Arg Ser Glu
                 495                 500                 505

 aac aaa gca cct cgt gcc aca ggg agg aac agt ggt aag aaa agg gct     2127
 Asn Lys Ala Pro Arg Ala Thr Gly Arg Asn Ser Gly Lys Lys Arg Ala
             510                 515                 520

 gcg gac agc ctg gac acc tgc cca act cca ccc aag cag gcc agg cca     2175
 Ala Asp Ser Leu Asp Thr Cys Pro Thr Pro Pro Lys Gln Ala Arg Pro
         525                 530                 535

 gag aat ggg gag tac ggc ccc tcc tcc atg ggc cag agc tcg gcc ttc     2223
 Glu Asn Gly Glu Tyr Gly Pro Ser Ser Met Gly Gln Ser Ser Ala Phe
     540                 545                 550

 cag ctg agt gca gac acc agc agt ggc tcc ttg tcg cca ggc agc agg     2271
 Gln Leu Ser Ala Asp Thr Ser Ser Gly Ser Leu Ser Pro Gly Ser Arg
 555                 560                 565                 570

 ccg tca ggg ggc atg gag gca ctg aag gct gca ggc cct gcg tcc ccg     2319
 Pro Ser Gly Gly Met Glu Ala Leu Lys Ala Ala Gly Pro Ala Ser Pro
                 575                 580                 585

 cct gag gag gac ccg gag cgc aca aag cac agc ctg gtc aaa gct gag     2367
 Pro Glu Glu Asp Pro Glu Arg Thr Lys His Ser Leu Val Lys Ala Glu
             590                 595                 600

 gac aag gcc cga gtt cac cgc tcc aag aag cag gag ggg cca ggc cct     2415
 Asp Lys Ala Arg Val His Arg Ser Lys Lys Gln Glu Gly Pro Gly Pro
         605                 610                 615

 gag gac gcc cgg aag aag gtg cca gct gcc ccc atc act gtc agc aag     2463
 Glu Asp Ala Arg Lys Lys Val Pro Ala Ala Pro Ile Thr Val Ser Lys
     620                 625                 630

 gag gca ccg gcc cct gtg gcc cac cca gct cca ggt ggc cct gaa gag     2511
 Glu Ala Pro Ala Pro Val Ala His Pro Ala Pro Gly Gly Pro Glu Glu
 635                 640                 645                 650

 cag tgg cag agg gcc atc cat gag cgc ggg gaa gcc gtc tgc ccc acc     2559
 Gln Trp Gln Arg Ala Ile His Glu Arg Gly Glu Ala Val Cys Pro Thr
                 655                 660                 665

 tgc aac gtg gtc acc cgg aag act ctc gtg ggg ctt aag aag cac atg     2607
 Cys Asn Val Val Thr Arg Lys Thr Leu Val Gly Leu Lys Lys His Met
             670                 675                 680

 gag gtg tgt cag aag ctt cag gat gca ctc aag tgc cag cac tgc cgg     2655
 Glu Val Cys Gln Lys Leu Gln Asp Ala Leu Lys Cys Gln His Cys Arg
         685                 690                 695

 aag cag ttc aag tcc aaa gcc ggc ctc aac tac cac act atg gcc gag     2703
 Lys Gln Phe Lys Ser Lys Ala Gly Leu Asn Tyr His Thr Met Ala Glu
     700                 705                 710

 cac agt gcc aag ccc tct gac gcc gag gcc tcc gaa ggg ggc gag cag     2751
 His Ser Ala Lys Pro Ser Asp Ala Glu Ala Ser Glu Gly Gly Glu Gln
 715                 720                 725                 730

 gag gag cgc gag agg ctg cgc aag gtg ctg aag cag atg gga cgg ctg     2799
 Glu Glu Arg Glu Arg Leu Arg Lys Val Leu Lys Gln Met Gly Arg Leu
                 735                 740                 745

 cgc tgc ccc cag gag ggt tgc ggg gct gcc ttc tcc agc ctc atg ggc     2847
 Arg Cys Pro Gln Glu Gly Cys Gly Ala Ala Phe Ser Ser Leu Met Gly
             750                 755                 760

 tac cag tac cac cag cgg cgc tgc ggg aag ccg ccc tgc gag gtg gac     2895
 Tyr Gln Tyr His Gln Arg Arg Cys Gly Lys Pro Pro Cys Glu Val Asp
         765                 770                 775

 agc ccc tcc ttc ccc tgc acc cac tgt ggc aag acg tac cga tcc aag     2943
 Ser Pro Ser Phe Pro Cys Thr His Cys Gly Lys Thr Tyr Arg Ser Lys
     780                 785                 790

 gct ggc cac gac tac cac gtg cgc tcg gag cac acg gcc ccc ccc cct     2991
 Ala Gly His Asp Tyr His Val Arg Ser Glu His Thr Ala Pro Pro Pro
 795                 800                 805                 810

 gag gag ccc aca gac aag tcc cct gag gct gag gac ccg ctg ggt gtg     3039
 Glu Glu Pro Thr Asp Lys Ser Pro Glu Ala Glu Asp Pro Leu Gly Val
                 815                 820                 825

 gag cgg acc cca agc ggg cgt gtc cgc cgc acg tcg gcc cag gtg gcg     3087
 Glu Arg Thr Pro Ser Gly Arg Val Arg Arg Thr Ser Ala Gln Val Ala
             830                 835                 840

 gtg ttc cac ctg cag gag ata gcg gag gac gag ctg gcc cgc gac tgg     3135
 Val Phe His Leu Gln Glu Ile Ala Glu Asp Glu Leu Ala Arg Asp Trp
         845                 850                 855

 acc aag cgg cgc atg aag gat gac ctt gtg ccc gag acc gca cgg ctc     3183
 Thr Lys Arg Arg Met Lys Asp Asp Leu Val Pro Glu Thr Ala Arg Leu
     860                 865                 870

 aac tac act cga cca ggg ctc ccc acg ctg aac ccc cag ctg cta gag     3231
 Asn Tyr Thr Arg Pro Gly Leu Pro Thr Leu Asn Pro Gln Leu Leu Glu
 875                 880                 885                 890

 gca tgg aag aat gaa gtg aag gag aaa ggc cac gtc aac tgt ccc aac     3279
 Ala Trp Lys Asn Glu Val Lys Glu Lys Gly His Val Asn Cys Pro Asn
                 895                 900                 905

 gac tgc tgt gaa gcc atc tac tcc agc gtg tcc gga ctc aag gct cat     3327
 Asp Cys Cys Glu Ala Ile Tyr Ser Ser Val Ser Gly Leu Lys Ala His
             910                 915                 920

 ctc gcc agc tgc agt aag ggg gcc cac ctg gca ggg aag tac cgc tgt     3375
 Leu Ala Ser Cys Ser Lys Gly Ala His Leu Ala Gly Lys Tyr Arg Cys
         925                 930                 935

 ctg ctg tgt ccg aag gag ttc agt tct gag agt ggc gtc aaa tac cac     3423
 Leu Leu Cys Pro Lys Glu Phe Ser Ser Glu Ser Gly Val Lys Tyr His
     940                 945                 950

 atc ctg aag acc cac gca gag aac tgg ttc cga aca tca gca gac cca     3471
 Ile Leu Lys Thr His Ala Glu Asn Trp Phe Arg Thr Ser Ala Asp Pro
 955                 960                 965                 970

 cct ccc aaa cac agg agc cag gac tca ttg gtg ccc aag aag aaa aaa     3519
 Pro Pro Lys His Arg Ser Gln Asp Ser Leu Val Pro Lys Lys Lys Lys
                 975                 980                 985

 aaa a                                                               3523
 Lys 






      <210> 518
      <211> 321
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(321)

      <400> 518
  atg aaa gta tac gta ctg cca gga aag tat aaa tat aac cgg gga agt      48
  Met Lys Val Tyr Val Leu Pro Gly Lys Tyr Lys Tyr Asn Arg Gly Ser
    1               5                  10                  15

 ata agt ata acc aat gaa agt ata agt act gcc agt gtt acc agg ggt       96
 Ile Ser Ile Thr Asn Glu Ser Ile Ser Thr Ala Ser Val Thr Arg Gly
              20                  25                  30

 cct tgc tcc gag agc tcc caa gat ggt ggt ggg cca ctt cca aaa tgg      144
 Pro Cys Ser Glu Ser Ser Gln Asp Gly Gly Gly Pro Leu Pro Lys Trp
          35                  40                  45

 cgg cag gcc act tcc aag atg gtg gca agc ctc gtg ttc tct gac ctg      192
 Arg Gln Ala Thr Ser Lys Met Val Ala Ser Leu Val Phe Ser Asp Leu
      50                  55                  60

 ggg ttc ttg gcc tca cgg att cca agg aat gga atc ttg ggc cgt gcg      240
 Gly Phe Leu Ala Ser Arg Ile Pro Arg Asn Gly Ile Leu Gly Arg Ala
  65                  70                  75                  80

 gtg agt gtt ata gct cta tta gaa gtc gtg ggt cac aga aga gaa ccg      288
 Val Ser Val Ile Ala Leu Leu Glu Val Val Gly His Arg Arg Glu Pro
                  85                  90                  95

 tgg aac cca gtg act agt gtt cag ctt gat tag                          321
 Trp Asn Pro Val Thr Ser Val Gln Leu Asp 
             100                 105





      <210> 519
      <211> 3280
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (15)..(2087)

      <400> 519
 accgctagag cgac  atg atg gtg gaa tct gcc tcg gag aca atc agg tcg      50
                  Met Met Val Glu Ser Ala Ser Glu Thr Ile Arg Ser
                    1               5                  10

 gct cca tct ggt cag aat ggc gtg ggc agc ctc tct ggg caa gcc gat       98
 Ala Pro Ser Gly Gln Asn Gly Val Gly Ser Leu Ser Gly Gln Ala Asp
          15                  20                  25

 ggc agc agc ggc ggg gcc aca ggg aca act gca agt ggc acg ggc agg      146
 Gly Ser Ser Gly Gly Ala Thr Gly Thr Thr Ala Ser Gly Thr Gly Arg
      30                  35                  40

 gaa gtg acc acg ggt gca gac agc aat ggt gag atg agt ccc gca gag      194
 Glu Val Thr Thr Gly Ala Asp Ser Asn Gly Glu Met Ser Pro Ala Glu
  45                  50                  55                  60

 ctg ctg cac ttc cag cag caa cag gct ctc caa gtg gcc cgg cag ttc      242
 Leu Leu His Phe Gln Gln Gln Gln Ala Leu Gln Val Ala Arg Gln Phe
                  65                  70                  75

 ctg ctg cag cag gcc tca ggc ctg agc tcc cca ggg aac aat gac agc      290
 Leu Leu Gln Gln Ala Ser Gly Leu Ser Ser Pro Gly Asn Asn Asp Ser
              80                  85                  90

 aaa cag tct gcc tct gct gtg cag ggg aca ggg cta acg ggc cga atc      338
 Lys Gln Ser Ala Ser Ala Val Gln Gly Thr Gly Leu Thr Gly Arg Ile
          95                 100                 105

 ctg cag gtg cct gtg tcg gtg gcc atg atg tcg ccg cag atg ctt acc      386
 Leu Gln Val Pro Val Ser Val Ala Met Met Ser Pro Gln Met Leu Thr
     110                 115                 120

 ccg caa cag atg cag cag atc ctg tcg ccc ccg cag ctg cag gcc ttg      434
 Pro Gln Gln Met Gln Gln Ile Leu Ser Pro Pro Gln Leu Gln Ala Leu
 125                 130                 135                 140

 ctc cag cag cag caa gcc ctc atg ctc cag cag cta cag gag tac tac      482
 Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Leu Gln Glu Tyr Tyr
                 145                 150                 155

 aag aag cag cag gag cag ctc cac ctg cag ctc ctc acc cag cag cag      530
 Lys Lys Gln Gln Glu Gln Leu His Leu Gln Leu Leu Thr Gln Gln Gln
             160                 165                 170

 gct ggg aaa ccg cag ccc aaa gag gca ctg ggg aac aag cag ctg gcc      578
 Ala Gly Lys Pro Gln Pro Lys Glu Ala Leu Gly Asn Lys Gln Leu Ala
         175                 180                 185

 ttc cag cag cag ctc ctg caa atg caa cag ttg cag cag cag cac ctg      626
 Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln Gln His Leu
     190                 195                 200

 ctc aac ctg cag agg cag ggg ctg gtc agc ctg cag ccc aac caa gcc      674
 Leu Asn Leu Gln Arg Gln Gly Leu Val Ser Leu Gln Pro Asn Gln Ala
 205                 210                 215                 220

 tcg ggg ccc ctc cag acc ctt ccg caa gca gct gtt tgc cca aca gac      722
 Ser Gly Pro Leu Gln Thr Leu Pro Gln Ala Ala Val Cys Pro Thr Asp
                 225                 230                 235

 ctg ccc cag ctg tgg aag ggc gag ggt gcc ccc ggg cag cct gcc gag      770
 Leu Pro Gln Leu Trp Lys Gly Glu Gly Ala Pro Gly Gln Pro Ala Glu
             240                 245                 250

 gac agc gtc aag cag gag ggg ctg gac ctc act ggc acg gcc gcc acc      818
 Asp Ser Val Lys Gln Glu Gly Leu Asp Leu Thr Gly Thr Ala Ala Thr
         255                 260                 265

 gct acc tcg ttt gcc gct ccc ccc aag gtc tca ccc ccc ctc tcc cac      866
 Ala Thr Ser Phe Ala Ala Pro Pro Lys Val Ser Pro Pro Leu Ser His
     270                 275                 280

 cat acc ctg ccc aac gga cag cct act gtg ctc aca tct cgg aga gac      914
 His Thr Leu Pro Asn Gly Gln Pro Thr Val Leu Thr Ser Arg Arg Asp
 285                 290                 295                 300

 agc tct tcc cac gag gag acc ccc ggc tcc cac ccc ctg tac gga cac      962
 Ser Ser Ser His Glu Glu Thr Pro Gly Ser His Pro Leu Tyr Gly His
                 305                 310                 315

 gga gag tgc aag tgg cca ggc tgt gag acc ctg tgt gaa gac ctg ggc     1010
 Gly Glu Cys Lys Trp Pro Gly Cys Glu Thr Leu Cys Glu Asp Leu Gly
             320                 325                 330

 cag ttt atc aaa cac ctc aac aca gag cac gcc ctg gat gac cgg agt     1058
 Gln Phe Ile Lys His Leu Asn Thr Glu His Ala Leu Asp Asp Arg Ser
         335                 340                 345

 aca gcc cag tgc cgg gta cag atg cag gtg gtg cag cag ctg gag atc     1106
 Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu Ile
     350                 355                 360

 cag ctc gcc aag gag agc gag cgg ctg cag gcc atg atg gcc cac ctg     1154
 Gln Leu Ala Lys Glu Ser Glu Arg Leu Gln Ala Met Met Ala His Leu
 365                 370                 375                 380

 cac atg cgg ccc tcg gag ccc aag ccc ttc agc cag cca ctg aac ccg     1202
 His Met Arg Pro Ser Glu Pro Lys Pro Phe Ser Gln Pro Leu Asn Pro
                 385                 390                 395

 gtc ccc ggc tcc tcc tca ttc tcc aag gtg acc gtc tct gca gca gac     1250
 Val Pro Gly Ser Ser Ser Phe Ser Lys Val Thr Val Ser Ala Ala Asp
             400                 405                 410

 tca ttc cca gat ggt ctc gtg cac ccc ccg acc tcg gcc gca gcc cct     1298
 Ser Phe Pro Asp Gly Leu Val His Pro Pro Thr Ser Ala Ala Ala Pro
         415                 420                 425

 gtc acc cct cta cgg ccc cct ggc ctg ggc tct gcc tcc ctg cat ggt     1346
 Val Thr Pro Leu Arg Pro Pro Gly Leu Gly Ser Ala Ser Leu His Gly
     430                 435                 440

 ggg ggc cca gcc cgt cgg aga agc agt gac aag ttc tgc tcc ccc atc     1394
 Gly Gly Pro Ala Arg Arg Arg Ser Ser Asp Lys Phe Cys Ser Pro Ile
 445                 450                 455                 460

 tcc tca gag ctg gcc cag aat cat gag ttc tac aag aac gcc gac gtc     1442
 Ser Ser Glu Leu Ala Gln Asn His Glu Phe Tyr Lys Asn Ala Asp Val
                 465                 470                 475

 cgg ccc ccc ttc acc tac gcc tcc ctc atc cgc cag gcc atc ctg gaa     1490
 Arg Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu
             480                 485                 490

 acc cct gac agg cag ctg acc ctg aat gag atc tat aac tgg ttc acc     1538
 Thr Pro Asp Arg Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr
         495                 500                 505

 agg atg ttc gcc tat ttc cgc aga aac act gcc acc tgg aag aac gcc     1586
 Arg Met Phe Ala Tyr Phe Arg Arg Asn Thr Ala Thr Trp Lys Asn Ala
     510                 515                 520

 gtg cgc cac aac ctc agc ctg cac aag tgc ttc gcc cgc gtg gag aac     1634
 Val Arg His Asn Leu Ser Leu His Lys Cys Phe Ala Arg Val Glu Asn
 525                 530                 535                 540

 gtc aag ggt gcc gtg tgg act gtg gac gag cgg gag tat cag aag cgg     1682
 Val Lys Gly Ala Val Trp Thr Val Asp Glu Arg Glu Tyr Gln Lys Arg
                 545                 550                 555

 aga ccg cca aag atg aca ggg agc ccc acc ctg gtg aag aac atg atc     1730
 Arg Pro Pro Lys Met Thr Gly Ser Pro Thr Leu Val Lys Asn Met Ile
             560                 565                 570

 tct ggc ctc agc tat gga gca ctt aat gcc agc tac cag gcc gcc ctg     1778
 Ser Gly Leu Ser Tyr Gly Ala Leu Asn Ala Ser Tyr Gln Ala Ala Leu
         575                 580                 585

 gcc gag agc agc ttc ccc ctc ctc aac agc cct ggc atg ctg aac cct     1826
 Ala Glu Ser Ser Phe Pro Leu Leu Asn Ser Pro Gly Met Leu Asn Pro
     590                 595                 600

 ggc tcc gcc agc agc ctg ctg ccc ctc agc cac gat gac gtg ggt gcc     1874
 Gly Ser Ala Ser Ser Leu Leu Pro Leu Ser His Asp Asp Val Gly Ala
 605                 610                 615                 620

 ccc gtg gag ccg ctg ccc agc aac ggc agc agc agc cct cct cgc ctc     1922
 Pro Val Glu Pro Leu Pro Ser Asn Gly Ser Ser Ser Pro Pro Arg Leu
                 625                 630                 635

 tcc ccg ccc cag tac agc cac cag gtg cag gtg aag gag gag cca gca     1970
 Ser Pro Pro Gln Tyr Ser His Gln Val Gln Val Lys Glu Glu Pro Ala
             640                 645                 650

 gag gca gag gaa gac agg cag ccc ggg cct ccc ctg ggc gcc cct aac     2018
 Glu Ala Glu Glu Asp Arg Gln Pro Gly Pro Pro Leu Gly Ala Pro Asn
         655                 660                 665

 ccc agc gcc tcg ggg cct ccg gaa gac agg gac ctg gag gag gag ctg     2066
 Pro Ser Ala Ser Gly Pro Pro Glu Asp Arg Asp Leu Glu Glu Glu Leu
     670                 675                 680

 ccg gga gaa gaa ctg tcc taa gg gcctgtagtg accggcaggg ctggggtgag     2119
 Pro Gly Glu Glu Leu Ser 
 685                 690

 acccctccct tccagaatcc attgggcccc atctccccca actccacagc ccctcccgag   2179

 cctcaaggca agtccaggac tcagaccggg gaggcccggg ccagcagctc ccagtgtgac   2239

 ctgacaaaaa cacgtagggg cagggacggt ccccaccccc agggacacaa cccctggtct   2299

 tggaccagta gaggacacgg agggttcaga ccacacatcc atcagacacc tcaccggaca   2359

 atctcgcaac tgcactacaa caaaagacac aaagagacac gacaaggcag cagccatcgc   2419

 caacgagacg agcacagaga agcaagacgc ggcggccaag aggagacaca gccgagaaaa   2479

 aaacggcgag agaacccagg accacaacca cagaccacaa gagccccaag ggcaccacaa   2539

 gcaagacgac ggaaacagga gacagcagga ggaagagccc cgcgaggagg acgaggcgac   2599

 accagggggc aaaggcagag agaaacaacc acaagaagag cgacagcaca cgaggcgccg   2659

 ccacgagcgc agagacgaag aggcgcgaga acgaagaaca aacgagcgac cgacacagca   2719

 gagcagacgc ggacaggcag agagaaccgg agagaggcca gagcacaccg acgagccgcg   2779

 aagaacacaa gagaacgaca gggggctccg agagacgaag agggagcaga ggcaggaggg   2839

 acagaaaacg acgagaggac acgacacgag acgacagccc aggacaagcg agaagacgaa   2899

 gcagaccgac ccgaccgaca aaccgacgag gagacaacaa cacaggcagg accagacgca   2959

 cgagacacac gcctaccaga gagagcggag gaaggcagac gagaaacaga agcaagagca   3019

 gaagaaagga cacaaaaaaa accaaccaga aaaacaccag aggcacaccg acgcgaccga   3079

 agagcaaacg acgagcagga gacgacagac agcacaaccc ggcagccaaa gaaagaagga   3139

 aacaaccacg caggaaacag ccaacaccga cagcgaggcg gaacacacta aaacgaggag   3199

 acgccaagaa caggacaaag cagacacaag aaagcgaaag caacgaaaga cgaagaacac   3259

 acgccaggag gagaaaagga g                                             3280




      <210> 520
      <211> 1387
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1140)

      <400> 520
  atg gtc gac aaa gcc aga gtg agc cag ggc tcc tgc tta tat gaa aag      48
  Met Val Asp Lys Ala Arg Val Ser Gln Gly Ser Cys Leu Tyr Glu Lys
    1               5                  10                  15

 gag gag tct gag tat att tgc ctg gtg atc ttt gca aaa aat gaa gag       96
 Glu Glu Ser Glu Tyr Ile Cys Leu Val Ile Phe Ala Lys Asn Glu Glu
              20                  25                  30

 atg acc aca gag gag acc cag ttc agg gaa aga gtc aga gat gca gct      144
 Met Thr Thr Glu Glu Thr Gln Phe Arg Glu Arg Val Arg Asp Ala Ala
          35                  40                  45

 gag ttg cca tgc cca ggg tta gtt aga gga aga gag aaa gta ttt gaa      192
 Glu Leu Pro Cys Pro Gly Leu Val Arg Gly Arg Glu Lys Val Phe Glu
      50                  55                  60

 gaa gag aag gca cat cca tcc tct gaa aag ctc agg ctt aga ggc aca      240
 Glu Glu Lys Ala His Pro Ser Ser Glu Lys Leu Arg Leu Arg Gly Thr
  65                  70                  75                  80

 cat agt ttc tct tac aag atg gga gag aat tcg cca aaa gga cat atc      288
 His Ser Phe Ser Tyr Lys Met Gly Glu Asn Ser Pro Lys Gly His Ile
                  85                  90                  95

 tta atg caa gaa agt cag aga aat gtc aaa cta tgt gcc agc cag agt      336
 Leu Met Gln Glu Ser Gln Arg Asn Val Lys Leu Cys Ala Ser Gln Ser
             100                 105                 110

 cct gtt act atg gaa gga gca tgt ggc aaa ctg atg aaa atc aca ggc      384
 Pro Val Thr Met Glu Gly Ala Cys Gly Lys Leu Met Lys Ile Thr Gly
         115                 120                 125

 cca gtt aca gtc aag aca tct gga acc cga ttt ggt gct tgg atg aca      432
 Pro Val Thr Val Lys Thr Ser Gly Thr Arg Phe Gly Ala Trp Met Thr
     130                 135                 140

 gac cct tta gca tct gag aaa aac aac aga gtc tgg tac atg gac agt      480
 Asp Pro Leu Ala Ser Glu Lys Asn Asn Arg Val Trp Tyr Met Asp Ser
 145                 150                 155                 160

 tat act aac aat aaa att gtt cgt gaa tac aaa tca att gca gac ttt      528
 Tyr Thr Asn Asn Lys Ile Val Arg Glu Tyr Lys Ser Ile Ala Asp Phe
                 165                 170                 175

 gtc agt ggg gct gaa tca agg aca tac aac ctt cct ttc aag tgg gca      576
 Val Ser Gly Ala Glu Ser Arg Thr Tyr Asn Leu Pro Phe Lys Trp Ala
             180                 185                 190

 gga act aac cat gtt gtc tac aat ggc tca ctc tat ttt aac aag tat      624
 Gly Thr Asn His Val Val Tyr Asn Gly Ser Leu Tyr Phe Asn Lys Tyr
         195                 200                 205

 cag agt aat atc atc atc aaa tac agc ttt gat atg ggg aga gtg ctt      672
 Gln Ser Asn Ile Ile Ile Lys Tyr Ser Phe Asp Met Gly Arg Val Leu
     210                 215                 220

 gcc caa cga agc ctg gag tat gct ggt ttt cat aat gtt tac ccc tac      720
 Ala Gln Arg Ser Leu Glu Tyr Ala Gly Phe His Asn Val Tyr Pro Tyr
 225                 230                 235                 240

 aca tgg ggt gga ttc tct gac atc gac cta atg gct gat gaa atc ggg      768
 Thr Trp Gly Gly Phe Ser Asp Ile Asp Leu Met Ala Asp Glu Ile Gly
                 245                 250                 255

 ctg tgg gct gtg tat gca act aac cag aat gca ggc aat att gtc atc      816
 Leu Trp Ala Val Tyr Ala Thr Asn Gln Asn Ala Gly Asn Ile Val Ile
             260                 265                 270

 agc caa ctt aac caa gat acc ttg gag gtg atg aag agc tgg agc act      864
 Ser Gln Leu Asn Gln Asp Thr Leu Glu Val Met Lys Ser Trp Ser Thr
         275                 280                 285

 ggc tac ccc aag aga agt gca ggg gaa tct ttc atg atc tgt ggg aca      912
 Gly Tyr Pro Lys Arg Ser Ala Gly Glu Ser Phe Met Ile Cys Gly Thr
     290                 295                 300

 ctg tat gtc acc aac tcc cac tta act gga gcc aag gtg tat tat tcc      960
 Leu Tyr Val Thr Asn Ser His Leu Thr Gly Ala Lys Val Tyr Tyr Ser
 305                 310                 315                 320

 tat tcc acc aaa acc tcc aca tat gag tac aca gac att ccc ttc cat     1008
 Tyr Ser Thr Lys Thr Ser Thr Tyr Glu Tyr Thr Asp Ile Pro Phe His
                 325                 330                 335

 aac caa tac ttt cac ata tcc atg ctt gac tac aat gca aga gat cga     1056
 Asn Gln Tyr Phe His Ile Ser Met Leu Asp Tyr Asn Ala Arg Asp Arg
             340                 345                 350

 gct ctc tat gcc tgg aac aat ggc cac cag gtg ctg ttc aat gtc acc     1104
 Ala Leu Tyr Ala Trp Asn Asn Gly His Gln Val Leu Phe Asn Val Thr
         355                 360                 365

 ctt ttc cat atc atc aag aca gag gat gac aca tag gcaa atgtgacatg     1154
 Leu Phe His Ile Ile Lys Thr Glu Asp Asp Thr 
     370                 375

 ttttcattga tttaaacagt gtgatttgtg ataaactcta taagacccct tccgtttttt   1214

 tcttcactat tatttttcat catttctcca aagcaaagca tttttattgt aaagttggtg   1274

 tttcaaaaac atagctgagc ttgtctaact taccatgttg gaaacacatc ttaacttcta   1334

 aatttacaag gcctatcatg tccttgtcat gaaaagcact aaaaaaaaaa aaa          1387




      <210> 521
      <211> 1307
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (3)..(884)

      <400> 521
 at   ttg gcc ctc gag gcc aag aat tcg gca cga ggg aaa ccc cgg act      47
      Leu Ala Leu Glu Ala Lys Asn Ser Ala Arg Gly Lys Pro Arg Thr
        1               5                  10                  15

 ggg atc atg gca gcc gag act cgg aac gtg gcc gga gca gag gcc cca       95
 Gly Ile Met Ala Ala Glu Thr Arg Asn Val Ala Gly Ala Glu Ala Pro
                  20                  25                  30

 ccg ccc cag aag cgc tac tac cgg caa cgt gct cac tcc aac ccc atg      143
 Pro Pro Gln Lys Arg Tyr Tyr Arg Gln Arg Ala His Ser Asn Pro Met
              35                  40                  45

 gcg gac cac acg ctg cgc tac cct gtg aag cca gag gag atg gac tgg      191
 Ala Asp His Thr Leu Arg Tyr Pro Val Lys Pro Glu Glu Met Asp Trp
          50                  55                  60

 tct gag cta tac cca gag ttc ttc gct cca ctc act caa aat cag agc      239
 Ser Glu Leu Tyr Pro Glu Phe Phe Ala Pro Leu Thr Gln Asn Gln Ser
      65                  70                  75

 cac gat gac cca aag gat aag aaa gaa aag aga gct cag gcc caa gtg      287
 His Asp Asp Pro Lys Asp Lys Lys Glu Lys Arg Ala Gln Ala Gln Val
  80                  85                  90                  95

 gag ttt gca gac ata ggc tgt ggc tat ggt ggc ctg tta gtg gaa ctg      335
 Glu Phe Ala Asp Ile Gly Cys Gly Tyr Gly Gly Leu Leu Val Glu Leu
                 100                 105                 110

 tca ccg ctg ttc cca gac aca ctt att ctg ggt ctg gag atc cgg gtg      383
 Ser Pro Leu Phe Pro Asp Thr Leu Ile Leu Gly Leu Glu Ile Arg Val
             115                 120                 125

 aag gtc tca gac tat gta caa gac cgg att cgg gcc cta cgc gca gct      431
 Lys Val Ser Asp Tyr Val Gln Asp Arg Ile Arg Ala Leu Arg Ala Ala
         130                 135                 140

 cct gca ggt ggc ttc cag aac atc gcc tgt ctc cgt agc aat gcc atg      479
 Pro Ala Gly Gly Phe Gln Asn Ile Ala Cys Leu Arg Ser Asn Ala Met
     145                 150                 155

 aag cac ctt cct aac ttc ttc tac aag ggc cag ctg aca aag atg ttc      527
 Lys His Leu Pro Asn Phe Phe Tyr Lys Gly Gln Leu Thr Lys Met Phe
 160                 165                 170                 175

 ttc ctc ttc ccc gac cca cat ttc aag cgg aca aag cac aag tgg cga      575
 Phe Leu Phe Pro Asp Pro His Phe Lys Arg Thr Lys His Lys Trp Arg
                 180                 185                 190

 atc atc agt ccc acc ctg cta gca gaa tat gcc tac gtg cta aga gtt      623
 Ile Ile Ser Pro Thr Leu Leu Ala Glu Tyr Ala Tyr Val Leu Arg Val
             195                 200                 205

 ggg ggg ctg gtg tat acc ata acc gat gtg ctg gag cta cac gac tgg      671
 Gly Gly Leu Val Tyr Thr Ile Thr Asp Val Leu Glu Leu His Asp Trp
         210                 215                 220

 atg tgc act cat ttc gaa gag cac cca ctg ttt gag cgt gtg cct ctg      719
 Met Cys Thr His Phe Glu Glu His Pro Leu Phe Glu Arg Val Pro Leu
     225                 230                 235

 gag gac ctg agt gaa gac ccc gtt gtg gga cat cta ggc acc tca act      767
 Glu Asp Leu Ser Glu Asp Pro Val Val Gly His Leu Gly Thr Ser Thr
 240                 245                 250                 255

 gag gag ggg aag aaa gtt cta cgt aat gga ggg aag aat ttc cca gcc      815
 Glu Glu Gly Lys Lys Val Leu Arg Asn Gly Gly Lys Asn Phe Pro Ala
                 260                 265                 270

 atc ttc cga aga ata caa gat ccc gtc ctc cag gca gtg acc tcc caa      863
 Ile Phe Arg Arg Ile Gln Asp Pro Val Leu Gln Ala Val Thr Ser Gln
             275                 280                 285

 acc agc ctg cct ggt cac tga ct gcttactcta ccttagctgg acctcgtctc      916
 Thr Ser Leu Pro Gly His 
         290

 ccagggatta gagaaaagag caggagtcct gggtcttccc agttgagact gctggagctg    976

 agacacagta ctctcttaaa gaaggtgggg agctgcccag ggcagaaccc actggtgttc   1036

 atgactaccc ctggctcctc tcaccttgtc cctccactgc caacagaaaa caaagcagct   1096

 gactgagatg gtcaaaggac tttggaccat aggggatctt tggaaggctg tggggtcttg   1156

 ctcttcctta gcactccttt ctccttgtga gatctctcct cagctggaat gaggaatgta   1216

 gtccatctaa actgcttgct aggctcaatt accacttctg tttgctttgt ggatcctggg   1276

 ataacatgta tatgtgtaca caaaaaaaaa a                                  1307




      <210> 522
      <211> 494
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (183)..(476)

      <400> 522
 cagacttaaa aagcgagaag tcttctgctt aaacaaattg cttttaaggc tggtacaaat     60

 tgatttacat acactctcag cgtgcgttat taaactacgg ctgggggtta ctttgtgcaa    120

 aggaaataat atgaagagag agcttctgaa ggagtatacc agcagggggc aaagcacatt    180

 gt   atg agg ggg caa aag gca gga cac cta aaa aat gat aca cat gtg     227
      Met Arg Gly Gln Lys Ala Gly His Leu Lys Asn Asp Thr His Val
        1               5                  10                  15

 cat gca cct gta tac aca ttc act gat gca cac aca tat aca cat gca      275
 His Ala Pro Val Tyr Thr Phe Thr Asp Ala His Thr Tyr Thr His Ala
                  20                  25                  30

 cat acc ctc aca tgt aca cat aca tat gca ctt aac aag cac ata cac      323
 His Thr Leu Thr Cys Thr His Thr Tyr Ala Leu Asn Lys His Ile His
              35                  40                  45

 ata ctt gta gaa aca cat gca cac acc ttc aca caa act tgc aca tac      371
 Ile Leu Val Glu Thr His Ala His Thr Phe Thr Gln Thr Cys Thr Tyr
          50                  55                  60

 aca cac ctg tat gtt cat ata cac att cat aaa cct act gat aca tgt      419
 Thr His Leu Tyr Val His Ile His Ile His Lys Pro Thr Asp Thr Cys
      65                  70                  75

 agg tat ata tac aga cat aca cac tct cac aca ccc act gta ttg cgt      467
 Arg Tyr Ile Tyr Arg His Thr His Ser His Thr Pro Thr Val Leu Arg
  80                  85                  90                  95

 ccg ctg tag agtatccaag attacgta                                      494
 Pro Leu 






      <210> 523
      <211> 2005
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (69)..(1469)

      <220>
      <221> misc_feature
      <222> (1)...(2005)
      <223> n = a,t,c or g

      <400> 523
 agatgagcgc ncccnccccc ttgannggca gcttgaatag cctgatgtat ataactatct     60

 attcgacg atg aag ata ccc cac caa acc caa aaa aag aga tct ctc gag     110
          Met Lys Ile Pro His Gln Thr Gln Lys Lys Arg Ser Leu Glu
            1               5                  10

 gat ccg aat tcg cgg ccg cgt cga cca agc ctc cgg agc gca cgt cgg      158
 Asp Pro Asn Ser Arg Pro Arg Arg Pro Ser Leu Arg Ser Ala Arg Arg
  15                  20                  25                  30

 cag tcg gct ccc tcg ttg acc gaa tca ccg acc tct ctc ccc agc tgt      206
 Gln Ser Ala Pro Ser Leu Thr Glu Ser Pro Thr Ser Leu Pro Ser Cys
                  35                  40                  45

 att tcc aaa atg tcg ctt tct aac aag ctg acg ctg gac aag ctg gac      254
 Ile Ser Lys Met Ser Leu Ser Asn Lys Leu Thr Leu Asp Lys Leu Asp
              50                  55                  60

 gtt aaa ggg aag cgg gtc gtt atg aga gtc gac ttc aat gtt cct atg      302
 Val Lys Gly Lys Arg Val Val Met Arg Val Asp Phe Asn Val Pro Met
          65                  70                  75

 aag aac aac cag ata aca aac aac cag agg att aag gct gct gtc cca      350
 Lys Asn Asn Gln Ile Thr Asn Asn Gln Arg Ile Lys Ala Ala Val Pro
      80                  85                  90

 agc atc aaa ttc tgc ttg gac aat gga gcc aag tcg gta gtc ctt atg      398
 Ser Ile Lys Phe Cys Leu Asp Asn Gly Ala Lys Ser Val Val Leu Met
  95                 100                 105                 110

 agc cac cta ggc cgg cct gat ggt gtg ccc atg cct gac aag tac tcc      446
 Ser His Leu Gly Arg Pro Asp Gly Val Pro Met Pro Asp Lys Tyr Ser
                 115                 120                 125

 tta gag cca gtt gct gta gaa ctc aaa tct ctg ctg ggc aag gat gtt      494
 Leu Glu Pro Val Ala Val Glu Leu Lys Ser Leu Leu Gly Lys Asp Val
             130                 135                 140

 ctg ttc ttg aag gac tgt gta ggc cca gaa gtg gag aaa gcc tgt gcc      542
 Leu Phe Leu Lys Asp Cys Val Gly Pro Glu Val Glu Lys Ala Cys Ala
         145                 150                 155

 aac cca gct gct ggg tct gtc atc ctg ctg gag aac ctc cgc ttt cat      590
 Asn Pro Ala Ala Gly Ser Val Ile Leu Leu Glu Asn Leu Arg Phe His
     160                 165                 170

 gtg gag gaa gaa ggg aag gga aaa gat gct tct ggg aac aag gtt aaa      638
 Val Glu Glu Glu Gly Lys Gly Lys Asp Ala Ser Gly Asn Lys Val Lys
 175                 180                 185                 190

 gcc gag cca gcc aaa ata gaa gct ttc cga gct tca ctt tcc aag cta      686
 Ala Glu Pro Ala Lys Ile Glu Ala Phe Arg Ala Ser Leu Ser Lys Leu
                 195                 200                 205

 ggg gat gtc tat gtc aat gat gct ttt ggc act gct cac aga gcc cac      734
 Gly Asp Val Tyr Val Asn Asp Ala Phe Gly Thr Ala His Arg Ala His
             210                 215                 220

 agc tcc atg gta gga gtc aat ctg cca cag aag gct ggt ggg ttt ttg      782
 Ser Ser Met Val Gly Val Asn Leu Pro Gln Lys Ala Gly Gly Phe Leu
         225                 230                 235

 atg aag aag gag ctg aac tac ttt gca aag gcc ttg gag agc cca gag      830
 Met Lys Lys Glu Leu Asn Tyr Phe Ala Lys Ala Leu Glu Ser Pro Glu
     240                 245                 250

 cga ccc ttc ctg gcc atc ctg ggc gga gct aaa gtt gca gac aag atc      878
 Arg Pro Phe Leu Ala Ile Leu Gly Gly Ala Lys Val Ala Asp Lys Ile
 255                 260                 265                 270

 cag ctc atc aat aat atg ctg gac aaa gtc aat gag atg att att ggt      926
 Gln Leu Ile Asn Asn Met Leu Asp Lys Val Asn Glu Met Ile Ile Gly
                 275                 280                 285

 ggt gga atg gct ttt acc ttc ctt aag gtg ctc aac aac atg gag att      974
 Gly Gly Met Ala Phe Thr Phe Leu Lys Val Leu Asn Asn Met Glu Ile
             290                 295                 300

 ggc act tct ctg ttt gat gaa gag gga gcc aag att gtc aaa gac cta     1022
 Gly Thr Ser Leu Phe Asp Glu Glu Gly Ala Lys Ile Val Lys Asp Leu
         305                 310                 315

 atg tcc aaa gct gag aag aat ggt gtg aag att acc ttg cct gtt gac     1070
 Met Ser Lys Ala Glu Lys Asn Gly Val Lys Ile Thr Leu Pro Val Asp
     320                 325                 330

 ttt gtc act gct gac aag ttt gat gag aat gcc aag act ggc caa gcc     1118
 Phe Val Thr Ala Asp Lys Phe Asp Glu Asn Ala Lys Thr Gly Gln Ala
 335                 340                 345                 350

 act gtg gct tct ggc ata cct gct ggc tgg atg ggc ttg gac tgt ggt     1166
 Thr Val Ala Ser Gly Ile Pro Ala Gly Trp Met Gly Leu Asp Cys Gly
                 355                 360                 365

 cct gaa agc agc aag aag tat gct gag gct gtc act cgg gct aag cag     1214
 Pro Glu Ser Ser Lys Lys Tyr Ala Glu Ala Val Thr Arg Ala Lys Gln
             370                 375                 380

 att gtg tgg aat ggt cct gtg ggg gta ttt gaa tgg gaa gct ttt gcc     1262
 Ile Val Trp Asn Gly Pro Val Gly Val Phe Glu Trp Glu Ala Phe Ala
         385                 390                 395

 cgg gga acc aaa gct ctc atg gat gag gtg gtg aaa gcc act tct agg     1310
 Arg Gly Thr Lys Ala Leu Met Asp Glu Val Val Lys Ala Thr Ser Arg
     400                 405                 410

 ggc tgc atc acc atc ata ggt ggt gga gac act gcc act tgc tgt gcc     1358
 Gly Cys Ile Thr Ile Ile Gly Gly Gly Asp Thr Ala Thr Cys Cys Ala
 415                 420                 425                 430

 aaa tgg aac acg gag gat aaa gtc agc cat gtg agc act ggg ggt ggt     1406
 Lys Trp Asn Thr Glu Asp Lys Val Ser His Val Ser Thr Gly Gly Gly
                 435                 440                 445

 gcc agt ttg gag ctc ctg gaa ggt aaa gtc ctt cct ggg gtg gat gct     1454
 Ala Ser Leu Glu Leu Leu Glu Gly Lys Val Leu Pro Gly Val Asp Ala
             450                 455                 460

 ctc agc aat att tag tactttcctg ccttttagtt cctgtgcaca gcccctaagt     1509
 Leu Ser Asn Ile 
         465

 caacttagca ttttctgcat ctccacttgg cattagctaa aaccttccat gtcaagattc   1569

 agctagtggc caagagatgc agtgccagga acccttaaac agttgcacag catctcagct   1629

 catcttcact gcaccctgga tttgcataca ttcttcaaga tcccatttga attttttagt   1689

 gactaaacca ttgtgcattc tagagtgcat atatttatat tttgcctgtt aaaaagaaag   1749

 tgagcagtgt tagcttagtt ctcttttgat gtaggttatt atgattagct ttgtcactgt   1809

 ttcactactc agcatggaaa caagatgaaa ttccatttgt aggtagtgag acaaaattga   1869

 tgatccatta agtaaacaat aaaagtgtcc attgaaaagt cgacgcggcc gcgaattcgg   1929

 atcctcgaga gatctctttt tttgggtttg gtggggtatc ttcatcatcg aatagatagt   1989

 tatatacatc atgcgt                                                   2005




      <210> 524
      <211> 988
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(783)

      <400> 524
  atg cag aaa tac gag aaa ctg gaa aag att ggg gaa ggc acc tac gga      48
  Met Gln Lys Tyr Glu Lys Leu Glu Lys Ile Gly Glu Gly Thr Tyr Gly
    1               5                  10                  15

 act gtg ttc aag gcc aaa aac cgg gag act cat gag atc gtg gct ctg       96
 Thr Val Phe Lys Ala Lys Asn Arg Glu Thr His Glu Ile Val Ala Leu
              20                  25                  30

 aaa cgg gtg agg ctg gat gac gat gat gag ggt gtg ccg agt tcc gcc      144
 Lys Arg Val Arg Leu Asp Asp Asp Asp Glu Gly Val Pro Ser Ser Ala
          35                  40                  45

 ctc cgg gag atc tgc cta ctc aag gag ctg aag cac aag aac atc gtc      192
 Leu Arg Glu Ile Cys Leu Leu Lys Glu Leu Lys His Lys Asn Ile Val
      50                  55                  60

 agg ctt cat gac gtc ctg cac agc gac aag aag ctg act ttg gtt ttt      240
 Arg Leu His Asp Val Leu His Ser Asp Lys Lys Leu Thr Leu Val Phe
  65                  70                  75                  80

 gaa ttc tgt gac cag gac ctg aag aag tat ttt gac agt tgc aat ggt      288
 Glu Phe Cys Asp Gln Asp Leu Lys Lys Tyr Phe Asp Ser Cys Asn Gly
                  85                  90                  95

 gac ctc gat cct gag att gta aag aat ggg gag ctg aaa ttg gct gat      336
 Asp Leu Asp Pro Glu Ile Val Lys Asn Gly Glu Leu Lys Leu Ala Asp
             100                 105                 110

 ttt ggc ctg gct cga gcc ttt ggg att ccc gtc cgc tgt tac tca gct      384
 Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Val Arg Cys Tyr Ser Ala
         115                 120                 125

 gag gtg gtc aca ctg tgg tac cgc cca ccg gat gtc ctc ttt ggg gcc      432
 Glu Val Val Thr Leu Trp Tyr Arg Pro Pro Asp Val Leu Phe Gly Ala
     130                 135                 140

 aag ctg tac tcc acg tcc atc gac atg tgg tca gcc ggc tgc atc ttt      480
 Lys Leu Tyr Ser Thr Ser Ile Asp Met Trp Ser Ala Gly Cys Ile Phe
 145                 150                 155                 160

 gca gag ctg gcc aat gct ggg cgg cct ctt ttt ccc ggc aat gat gtc      528
 Ala Glu Leu Ala Asn Ala Gly Arg Pro Leu Phe Pro Gly Asn Asp Val
                 165                 170                 175

 gat gac cag ttg aag agg atc ttc cga ctg ctg ggg acg ccc acc gag      576
 Asp Asp Gln Leu Lys Arg Ile Phe Arg Leu Leu Gly Thr Pro Thr Glu
             180                 185                 190

 gag cag tgg ccc tct atg acc aag ctg cca gac tat aag ccc tat ccg      624
 Glu Gln Trp Pro Ser Met Thr Lys Leu Pro Asp Tyr Lys Pro Tyr Pro
         195                 200                 205

 atg tac ccg gcc aca aca tcc ctg gtg aac gtc gtg ccc aaa ctc aat      672
 Met Tyr Pro Ala Thr Thr Ser Leu Val Asn Val Val Pro Lys Leu Asn
     210                 215                 220

 gcc aca ggg agg gat ctg ctg cag aac ctt ctg aag tgt aac cct gtc      720
 Ala Thr Gly Arg Asp Leu Leu Gln Asn Leu Leu Lys Cys Asn Pro Val
 225                 230                 235                 240

 cag cgt atc tca gca gaa gag gcc ctg cag cac ccc tac ttc tcc gac      768
 Gln Arg Ile Ser Ala Glu Glu Ala Leu Gln His Pro Tyr Phe Ser Asp
                 245                 250                 255

 ttc tgt ccg ccc tag gccccgggac ccccggcctc caggctgggg cctggcctat      823
 Phe Cys Pro Pro 
             260

 ttaagccccc tcttgagagg ggtgagacag tgggggtgcc tggtgcgctg tgctccagca    883

 gtgctgggcc cagccggggt ggggtgcctg agcccgaatt tctcactccc tttgtggact    943

 ttatttaatt tcataaattg gctcctttcc cacaaaaaaa aaaaa                    988




      <210> 525
      <211> 1180
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (105)..(1133)

      <400> 525
 ggcgccggca cacctattgg cccccgcggc gtcccgtcgc cgcgtcgcgt tgctggcccg     60

 tcggagcgac gccgctcggg tcagtcggcg gccggactgg gaag atg gac gca gct     116
                                                  Met Asp Ala Ala
                                                    1

 act ctg acc tac gac act ctc cgg ttt gct gag ttt gaa gat ttt cct      164
 Thr Leu Thr Tyr Asp Thr Leu Arg Phe Ala Glu Phe Glu Asp Phe Pro
   5                  10                  15                  20

 gag acc tca gag ccc gtt tgg ata ctg ggt aga aaa tac agc att ttc      212
 Glu Thr Ser Glu Pro Val Trp Ile Leu Gly Arg Lys Tyr Ser Ile Phe
                  25                  30                  35

 aca gaa aag gac gag atc ttg tct gat gtg gca tct aga ctt tgg ttt      260
 Thr Glu Lys Asp Glu Ile Leu Ser Asp Val Ala Ser Arg Leu Trp Phe
              40                  45                  50

 aca tac agg aaa aac ttt cca gcc att ggg ggg aca ggc ccc acc tcg      308
 Thr Tyr Arg Lys Asn Phe Pro Ala Ile Gly Gly Thr Gly Pro Thr Ser
          55                  60                  65

 gac aca ggc tgg ggc tgc atg ctg cgg tgt gga cag atg atc ttt gcc      356
 Asp Thr Gly Trp Gly Cys Met Leu Arg Cys Gly Gln Met Ile Phe Ala
      70                  75                  80

 caa gcc ctg gtg tgc cgg cac cta ggc cga gat tgg agg tgg aca caa      404
 Gln Ala Leu Val Cys Arg His Leu Gly Arg Asp Trp Arg Trp Thr Gln
  85                  90                  95                 100

 agg aag agg cag cca gac agc tac ttc agc gtc ctc aac gca ttc atc      452
 Arg Lys Arg Gln Pro Asp Ser Tyr Phe Ser Val Leu Asn Ala Phe Ile
                 105                 110                 115

 gac agg aag gac agt tac tac tcc att cac cag ata gga agg ttg tgc      500
 Asp Arg Lys Asp Ser Tyr Tyr Ser Ile His Gln Ile Gly Arg Leu Cys
             120                 125                 130

 agg acc agc gtt ccc tgt gca ggc gcc act gcg ttt cct gca gat tcc      548
 Arg Thr Ser Val Pro Cys Ala Gly Ala Thr Ala Phe Pro Ala Asp Ser
         135                 140                 145

 gac cgg cac tgc aac gga ttc cct gcc gga gct gag gtc acc aac agg      596
 Asp Arg His Cys Asn Gly Phe Pro Ala Gly Ala Glu Val Thr Asn Arg
     150                 155                 160

 ccg tcg cca tgg aga ccc ctg gta ctt ctc att ccc ctg cgc ctg ggg      644
 Pro Ser Pro Trp Arg Pro Leu Val Leu Leu Ile Pro Leu Arg Leu Gly
 165                 170                 175                 180

 ctc acg gac atc aac gag gcc tac gtg gag acg ctg aag cac tgc ttc      692
 Leu Thr Asp Ile Asn Glu Ala Tyr Val Glu Thr Leu Lys His Cys Phe
                 185                 190                 195

 atg atg ccc cag tcc ctg ggc gtc atc gga ggg aag ccc aac agc gcc      740
 Met Met Pro Gln Ser Leu Gly Val Ile Gly Gly Lys Pro Asn Ser Ala
             200                 205                 210

 cac tac ttc atc ggc tac gtt ggt gag gag ctc atc tac ctg gac ccc      788
 His Tyr Phe Ile Gly Tyr Val Gly Glu Glu Leu Ile Tyr Leu Asp Pro
         215                 220                 225

 cac acc acg cag cca gcc gtg gag ccc act gat ggc tgc ttc atc ccg      836
 His Thr Thr Gln Pro Ala Val Glu Pro Thr Asp Gly Cys Phe Ile Pro
     230                 235                 240

 gac gag agc ttc cac tgc cag cac ccg ccg tgc cgc atg agc atc gcg      884
 Asp Glu Ser Phe His Cys Gln His Pro Pro Cys Arg Met Ser Ile Ala
 245                 250                 255                 260

 gag ctt gac ccg tcc atc gct gtg ggg ttt ttc tgt aag act gaa gat      932
 Glu Leu Asp Pro Ser Ile Ala Val Gly Phe Phe Cys Lys Thr Glu Asp
                 265                 270                 275

 gac ttc aat gat tgg tgc cag caa gtc aaa aag ctg tct ctg ctt gga      980
 Asp Phe Asn Asp Trp Cys Gln Gln Val Lys Lys Leu Ser Leu Leu Gly
             280                 285                 290

 ggt gcc ctg ccc atg ttt gag ctg gtg gag cag cag cct tca cat ctg     1028
 Gly Ala Leu Pro Met Phe Glu Leu Val Glu Gln Gln Pro Ser His Leu
         295                 300                 305

 gcc tgc ccc gac gtc ctg aac ctg tcc cta gat tct tct gat gta gag     1076
 Ala Cys Pro Asp Val Leu Asn Leu Ser Leu Asp Ser Ser Asp Val Glu
     310                 315                 320

 cga ctg gaa aga ttc ttc gac tca gaa gat gaa gac ttt gaa atc ctg     1124
 Arg Leu Glu Arg Phe Phe Asp Ser Glu Asp Glu Asp Phe Glu Ile Leu
 325                 330                 335                 340

 tcc ctt tga aaatcct ggggtcgggg gtggcacctg tgagagcctg gggctcctgg     1180
 Ser Leu 






      <210> 526
      <211> 1522
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (230)..(979)

      <400> 526
 tagtagaggc cggggtataa tcggcagagg cgagctgacc ctgatcaggg ccgagttgtc     60

 tcggcggcgc tgccgaggcc tccacccagg acagtccccc tccccgggcc tctctcctct    120

 tgcctacgag tcccctctcc tcgtaggcct ctcggatctg atatcgtggg gtgaggtgag    180

 caggcccggg gagggtggtt accgctgagg agctgcagtc tctgtcaag    atg ata     235
                                                          Met Ile
                                                            1

 gag gta ctg aca aca act gac tct cag aaa ctg cta cac cag ctg aat      283
 Glu Val Leu Thr Thr Thr Asp Ser Gln Lys Leu Leu His Gln Leu Asn
           5                  10                  15

 gcc ctg ttg gaa cag gag tct aga tgt cag cca aag gtc tgt ggt ttg      331
 Ala Leu Leu Glu Gln Glu Ser Arg Cys Gln Pro Lys Val Cys Gly Leu
      20                  25                  30

 aga cta att gag tct gca cac gat aat ggc ctc aga atg act gca aga      379
 Arg Leu Ile Glu Ser Ala His Asp Asn Gly Leu Arg Met Thr Ala Arg
  35                  40                  45                  50

 cta agg gac ttt gaa gta aaa gat ctt ctt agt cta act cag ttc ttt      427
 Leu Arg Asp Phe Glu Val Lys Asp Leu Leu Ser Leu Thr Gln Phe Phe
                  55                  60                  65

 ggc ttt gac aca gag aca ttt tct cta gct gtg aat tta ctg gac aga      475
 Gly Phe Asp Thr Glu Thr Phe Ser Leu Ala Val Asn Leu Leu Asp Arg
              70                  75                  80

 ttc ctg tct aaa atg aag gta cag ccc aag cac ctt ggg tgt gtt gga      523
 Phe Leu Ser Lys Met Lys Val Gln Pro Lys His Leu Gly Cys Val Gly
          85                  90                  95

 ctg agc tgc ttt tat ttg gct gta aaa tca ata gaa gag gaa agg aat      571
 Leu Ser Cys Phe Tyr Leu Ala Val Lys Ser Ile Glu Glu Glu Arg Asn
     100                 105                 110

 gtc cca ttg gca act gac ttg atc cga ata agt caa tat agg ttt acg      619
 Val Pro Leu Ala Thr Asp Leu Ile Arg Ile Ser Gln Tyr Arg Phe Thr
 115                 120                 125                 130

 gtt tca gac ttg atg aga atg gaa aag att gta ttg gag aag gtg tgt      667
 Val Ser Asp Leu Met Arg Met Glu Lys Ile Val Leu Glu Lys Val Cys
                 135                 140                 145

 tgg aaa gtc aaa gct act act gcc ttt caa ttt ctg caa ctg tat tat      715
 Trp Lys Val Lys Ala Thr Thr Ala Phe Gln Phe Leu Gln Leu Tyr Tyr
             150                 155                 160

 tca ctc ctt caa gag aac ttg cca ctt gaa agg aga aat agc att aat      763
 Ser Leu Leu Gln Glu Asn Leu Pro Leu Glu Arg Arg Asn Ser Ile Asn
         165                 170                 175

 ttt gaa aga cta gaa gct caa ctg aag gca tgt cat tgc agg atc ata      811
 Phe Glu Arg Leu Glu Ala Gln Leu Lys Ala Cys His Cys Arg Ile Ile
     180                 185                 190

 ttt tct aaa gca aag cct tct gtg tgg cat gtc tat cat tgc att aga      859
 Phe Ser Lys Ala Lys Pro Ser Val Trp His Val Tyr His Cys Ile Arg
 195                 200                 205                 210

 gat cca agc aca gaa gtg tgt aga gtt aac aga agg aat aga atg tct      907
 Asp Pro Ser Thr Glu Val Cys Arg Val Asn Arg Arg Asn Arg Met Ser
                 215                 220                 225

 tca gaa aca ttc caa gat aaa tgg cag aga tct gac ctt ctg gca aga      955
 Ser Glu Thr Phe Gln Asp Lys Trp Gln Arg Ser Asp Leu Leu Ala Arg
             230                 235                 240

 gct tgt atc caa atg ttt aac tga atattcatca aataagtgtt ccaaaccaaa    1009
 Ala Cys Ile Gln Met Phe Asn 
         245

 tgttcagaag ttgaaatgga ttgtttctgg ggcgtactgg cacggcaatg gaagcatagc   1069

 tactacagaa taactcacct tccaacaatt cctgaaatgg tcccttaact gggattatta   1129

 cagcaccaaa aaacttctct gaagcctttc tccacaactt gttctatgga ttccataatg   1189

 gttacaatgg atttaagcta tgaagcctca gaagcatgca cggagataag gccttggatg   1249

 gtcttcagaa ccctgggaaa aacgtgccta ataattattg gctcgtagtg gacctatagg   1309

 tttacgaatc atgaattcct cctgtgcagc gccttccaaa ttcaaggtaa aagccaaatg   1369

 tgaaagttgt tgaagcctgg gacggagccg ggagctccct ccacatgagc tgctcaatcg   1429

 gcacaactag ggggggagaa gatggggggg cgcaatataa agctgccggg tcgttgatac   1489

 cccacattat agagtataga ccacataaca ggc                                1522




      <210> 527
      <211> 1429
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (51)..(1337)

      <400> 527
 ctcagatcac actatctcca cttgcccagc cctgtggaag attagcggcc   atg tat      56
                                                          Met Tyr
                                                            1

 tcc aat gtg ata gga act gta acc tct gga acc tgt cac ggg agc cct      104
 Ser Asn Val Ile Gly Thr Val Thr Ser Gly Thr Cys His Gly Ser Pro
           5                  10                  15

 gtg gac atc tgc aca gcc aag ccg cgg gac att ccc atg aat ccc atg      152
 Val Asp Ile Cys Thr Ala Lys Pro Arg Asp Ile Pro Met Asn Pro Met
      20                  25                  30

 tgc att tac cgc tcc ccg gag aag aag gca act gag gat gag ggc tca      200
 Cys Ile Tyr Arg Ser Pro Glu Lys Lys Ala Thr Glu Asp Glu Gly Ser
  35                  40                  45                  50

 gaa cag aag atc ccg gag gcc acc aac cgg cgt gtc tgg gaa ctg tcc      248
 Glu Gln Lys Ile Pro Glu Ala Thr Asn Arg Arg Val Trp Glu Leu Ser
                  55                  60                  65

 aag gcc aat tcc cgc ttt gct acc act ttc tat cag cac ctg gca gat      296
 Lys Ala Asn Ser Arg Phe Ala Thr Thr Phe Tyr Gln His Leu Ala Asp
              70                  75                  80

 tcc aag aat gac aat gat aac att ttc ctg tca ccc ctg agt atc tcc      344
 Ser Lys Asn Asp Asn Asp Asn Ile Phe Leu Ser Pro Leu Ser Ile Ser
          85                  90                  95

 acg gct ttt gct atg acc aag ctg ggt gcc tgt aat gac acc ctc cag      392
 Thr Ala Phe Ala Met Thr Lys Leu Gly Ala Cys Asn Asp Thr Leu Gln
     100                 105                 110

 caa ctg atg gag gta ttt aag ttt gac acc ata tct gag aaa aca tct      440
 Gln Leu Met Glu Val Phe Lys Phe Asp Thr Ile Ser Glu Lys Thr Ser
 115                 120                 125                 130

 gat cag atc cac ttc ttc ttt gcc aaa ctg aac tgc cga ctc tat cga      488
 Asp Gln Ile His Phe Phe Phe Ala Lys Leu Asn Cys Arg Leu Tyr Arg
                 135                 140                 145

 aaa gcc aac aaa tcc tcc aag tta gta tca gcc aat cgc ctt ttt gga      536
 Lys Ala Asn Lys Ser Ser Lys Leu Val Ser Ala Asn Arg Leu Phe Gly
             150                 155                 160

 gac aaa tcc ctt acc ttc aat gag acc tac cag gac atc agt gag ttg      584
 Asp Lys Ser Leu Thr Phe Asn Glu Thr Tyr Gln Asp Ile Ser Glu Leu
         165                 170                 175

 gta tat gga gcc aag ctc cag ccc ctg gac ttc aag gaa ggc cga atc      632
 Val Tyr Gly Ala Lys Leu Gln Pro Leu Asp Phe Lys Glu Gly Arg Ile
     180                 185                 190

 acc gat gtc att ccc tcg gaa gcc atc aat gag ctc act gtt ctg gtg      680
 Thr Asp Val Ile Pro Ser Glu Ala Ile Asn Glu Leu Thr Val Leu Val
 195                 200                 205                 210

 ctg gtt aac acc att tac ttc aag ggc ctg tgg aag tca aag ttc agc      728
 Leu Val Asn Thr Ile Tyr Phe Lys Gly Leu Trp Lys Ser Lys Phe Ser
                 215                 220                 225

 cct gag aac aca agg aag gaa ctg ttc tac aag gct gat gga gag tcg      776
 Pro Glu Asn Thr Arg Lys Glu Leu Phe Tyr Lys Ala Asp Gly Glu Ser
             230                 235                 240

 tgt tca gca tct atg atg tac cag gaa ggc aag ttc cgt tat cgg cgc      824
 Cys Ser Ala Ser Met Met Tyr Gln Glu Gly Lys Phe Arg Tyr Arg Arg
         245                 250                 255

 gtg gct gaa agc acc cag gtg ctt gag ttg ccc ttc aaa ggt gat gac      872
 Val Ala Glu Ser Thr Gln Val Leu Glu Leu Pro Phe Lys Gly Asp Asp
     260                 265                 270

 atc acc atg gtc ctc atc ttg ccc aag cct gag aag agc ctg gcc aag      920
 Ile Thr Met Val Leu Ile Leu Pro Lys Pro Glu Lys Ser Leu Ala Lys
 275                 280                 285                 290

 gtg gag aag gaa ctc acc cca gag gtg ctg caa gag tgg ctg gat gaa      968
 Val Glu Lys Glu Leu Thr Pro Glu Val Leu Gln Glu Trp Leu Asp Glu
                 295                 300                 305

 ttg gag gag atg atg ctg gtg gtc cac atg ccc cgc ttt cgc att gag     1016
 Leu Glu Glu Met Met Leu Val Val His Met Pro Arg Phe Arg Ile Glu
             310                 315                 320

 gac cgg ttc agt ttg aag gag cag ctg caa gac atg ggc ctt gtc gat     1064
 Asp Arg Phe Ser Leu Lys Glu Gln Leu Gln Asp Met Gly Leu Val Asp
         325                 330                 335

 ctg ttc agc cct gaa aag tcc aaa ctc cca ggt att gtt gca gaa ggc     1112
 Leu Phe Ser Pro Glu Lys Ser Lys Leu Pro Gly Ile Val Ala Glu Gly
     340                 345                 350

 cga gat gac ctc tat gtc tca gat gca ttc cat aag gca ttt ctt gag     1160
 Arg Asp Asp Leu Tyr Val Ser Asp Ala Phe His Lys Ala Phe Leu Glu
 355                 360                 365                 370

 gta aat gaa gaa ggc agt gaa gca gct gca agt acc gct gtt gtg att     1208
 Val Asn Glu Glu Gly Ser Glu Ala Ala Ala Ser Thr Ala Val Val Ile
                 375                 380                 385

 gct ggc cgt tcg cta aac ccc aac agg gtg act ttc aag gcc aac agg     1256
 Ala Gly Arg Ser Leu Asn Pro Asn Arg Val Thr Phe Lys Ala Asn Arg
             390                 395                 400

 cct ttc ctg gtt ttt ata aga gaa gtt cct ctg aac act att atc ttc     1304
 Pro Phe Leu Val Phe Ile Arg Glu Val Pro Leu Asn Thr Ile Ile Phe
         405                 410                 415

 atg ggc aga gta gcc aac cct tgt gtt aag taa aatgttct tattctttgc     1355
 Met Gly Arg Val Ala Asn Pro Cys Val Lys 
     420                 425

 acctcttcct atttttggtt tgtgaacaga agtaaaaata aatacaaact acttccatct   1415

 caaaaaaaaa aaaa                                                     1429




      <210> 528
      <211> 1041
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1041)

      <400> 528
  atg tcc atg ttc caa atg agg aaa ctg aag aat gga gaa agg gcc aat      48
  Met Ser Met Phe Gln Met Arg Lys Leu Lys Asn Gly Glu Arg Ala Asn
    1               5                  10                  15

 gag aca gta tca caa tca gtg gtc ccc aaa tcc ccc cac cat ctc gct       96
 Glu Thr Val Ser Gln Ser Val Val Pro Lys Ser Pro His His Leu Ala
              20                  25                  30

 gtc agt tac ctc agc agt agt ctc caa ccg ttc ttc ctc atc aca ccc      144
 Val Ser Tyr Leu Ser Ser Ser Leu Gln Pro Phe Phe Leu Ile Thr Pro
          35                  40                  45

 cca gtg atc ata aca cac atc atc agt ggt cac atg gcc aaa cac aga      192
 Pro Val Ile Ile Thr His Ile Ile Ser Gly His Met Ala Lys His Arg
      50                  55                  60

 agg gat ttg gca gag ggg cat agc ccg gaa caa gtg ctg gac aca gag      240
 Arg Asp Leu Ala Glu Gly His Ser Pro Glu Gln Val Leu Asp Thr Glu
  65                  70                  75                  80

 cct ggc aca gca gag ggg ctc cac tgc cag aaa aaa caa tgg cca cac      288
 Pro Gly Thr Ala Glu Gly Leu His Cys Gln Lys Lys Gln Trp Pro His
                  85                  90                  95

 tct cca gtg ctg ccc ctg ctg ctt gta ctg tcc tca gag cag cca cca      336
 Ser Pro Val Leu Pro Leu Leu Leu Val Leu Ser Ser Glu Gln Pro Pro
             100                 105                 110

 gtg ctc agg gac ttc aac atc aag ctg ttc tac ttc agg ttc tcc aag      384
 Val Leu Arg Asp Phe Asn Ile Lys Leu Phe Tyr Phe Arg Phe Ser Lys
         115                 120                 125

 ctc tgc ctg cgg gat gac agt ggc caa cag aga tta agc aag aac ttc      432
 Leu Cys Leu Arg Asp Asp Ser Gly Gln Gln Arg Leu Ser Lys Asn Phe
     130                 135                 140

 tgc ggg ttg gtg gca tat gca gcc ccc gag ctg ctg cag ggc atc ccc      480
 Cys Gly Leu Val Ala Tyr Ala Ala Pro Glu Leu Leu Gln Gly Ile Pro
 145                 150                 155                 160

 tac cag ccc atg gtg tat gac atc tgg agc ctg ggc atg atc ctc tac      528
 Tyr Gln Pro Met Val Tyr Asp Ile Trp Ser Leu Gly Met Ile Leu Tyr
                 165                 170                 175

 atc atg gtc tgc agc tcc atg cct tac gac tcc aac atc agg aag atg      576
 Ile Met Val Cys Ser Ser Met Pro Tyr Asp Ser Asn Ile Arg Lys Met
             180                 185                 190

 ctg cgt atc cag aag gag cac cgc gtg gac ttc cca cac tcc aag aac      624
 Leu Arg Ile Gln Lys Glu His Arg Val Asp Phe Pro His Ser Lys Asn
         195                 200                 205

 ctg aca gac gag tgc aag gac ctc atc tac tgc atg ctg cag ccc gac      672
 Leu Thr Asp Glu Cys Lys Asp Leu Ile Tyr Cys Met Leu Gln Pro Asp
     210                 215                 220

 gtc agc cag cgg ctg cac atc cat gac acc ctc agc caa tgc tgg gtg      720
 Val Ser Gln Arg Leu His Ile His Asp Thr Leu Ser Gln Cys Trp Val
 225                 230                 235                 240

 cag ccc aag gca cag gga ctg ccc tct atg gtc ttc aac aag gag ggg      768
 Gln Pro Lys Ala Gln Gly Leu Pro Ser Met Val Phe Asn Lys Glu Gly
                 245                 250                 255

 gaa agc tcc cag gga act gaa ctc ttg tgg acc cct gaa cct ggc tct      816
 Glu Ser Ser Gln Gly Thr Glu Leu Leu Trp Thr Pro Glu Pro Gly Ser
             260                 265                 270

 gcc aag agg tct gcc acc aag ctg gag cct ggg gaa cag aca cag ccc      864
 Ala Lys Arg Ser Ala Thr Lys Leu Glu Pro Gly Glu Gln Thr Gln Pro
         275                 280                 285

 gag gga cag cct gag aca aaa cct gag ggg ttg gca atg caa atg tcc      912
 Glu Gly Gln Pro Glu Thr Lys Pro Glu Gly Leu Ala Met Gln Met Ser
     290                 295                 300

 agg cag tcg gac atc cta ggc ttc ccc agc aag ccg tcg acc agg gag      960
 Arg Gln Ser Asp Ile Leu Gly Phe Pro Ser Lys Pro Ser Thr Arg Glu
 305                 310                 315                 320

 aaa gag gaa ggg ccc ccc agc agc ctc cag aga tgc gca cct agt gag     1008
 Lys Glu Glu Gly Pro Pro Ser Ser Leu Gln Arg Cys Ala Pro Ser Glu
                 325                 330                 335

 ccg ttt gtg gcc cag tgt gcc agc ggc gaa tga                         1041
 Pro Phe Val Ala Gln Cys Ala Ser Gly Glu 
             340                 345





      <210> 529
      <211> 1849
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (11)..(1723)

      <400> 529
 gaaaatatac   atg caa gaa ggc aaa cca aac tta ttg gac atg ggc tct      49
              Met Gln Glu Gly Lys Pro Asn Leu Leu Asp Met Gly Ser
                1               5                  10

 ttg atg atc aaa cca att caa cgt gtg atg aaa tac ccc cta tta ctg       97
 Leu Met Ile Lys Pro Ile Gln Arg Val Met Lys Tyr Pro Leu Leu Leu
      15                  20                  25

 tgc gaa ctt cgg aat tcc acc cct ccc tct cac cca gat tac aga gca      145
 Cys Glu Leu Arg Asn Ser Thr Pro Pro Ser His Pro Asp Tyr Arg Ala
  30                  35                  40                  45

 ctg gac gat gcc ttt gct gct gtg aag gac att aat gtt aac atc aat      193
 Leu Asp Asp Ala Phe Ala Ala Val Lys Asp Ile Asn Val Asn Ile Asn
                  50                  55                  60

 gaa ctt aaa aga agg aaa gat tta ggt gag aat gta ctt gga atc act      241
 Glu Leu Lys Arg Arg Lys Asp Leu Gly Glu Asn Val Leu Gly Ile Thr
              65                  70                  75

 agt tta gag aac aac ttg aca ata cct agc aaa gtt gaa gat gca cag      289
 Ser Leu Glu Asn Asn Leu Thr Ile Pro Ser Lys Val Glu Asp Ala Gln
          80                  85                  90

 acc gga gac tca gaa aat gaa ttt cta agt att tgc cca aga gag act      337
 Thr Gly Asp Ser Glu Asn Glu Phe Leu Ser Ile Cys Pro Arg Glu Thr
      95                 100                 105

 ctt gcc cat gtg ctc aaa gag agg tgt act gtt cta aaa tac aag aag      385
 Leu Ala His Val Leu Lys Glu Arg Cys Thr Val Leu Lys Tyr Lys Lys
 110                 115                 120                 125

 aat gac gag gat gaa tca ctt aaa gac aaa ttg tct aaa cta aat att      433
 Asn Asp Glu Asp Glu Ser Leu Lys Asp Lys Leu Ser Lys Leu Asn Ile
                 130                 135                 140

 cat tca att agc aag aaa tca aaa aga gtg aca aat cat ctg aag att      481
 His Ser Ile Ser Lys Lys Ser Lys Arg Val Thr Asn His Leu Lys Ile
             145                 150                 155

 ctg acc aga gga gaa tca cag gat gcc atg ccc ctg gct ctg cag agt      529
 Leu Thr Arg Gly Glu Ser Gln Asp Ala Met Pro Leu Ala Leu Gln Ser
         160                 165                 170

 gtg atg gac ctt cag gag att tca tac aac aaa gac gat gag atg gac      577
 Val Met Asp Leu Gln Glu Ile Ser Tyr Asn Lys Asp Asp Glu Met Asp
     175                 180                 185

 tat tct gag acc cta agt aat gcc tta aat tcg tgt cat gac ttt gca      625
 Tyr Ser Glu Thr Leu Ser Asn Ala Leu Asn Ser Cys His Asp Phe Ala
 190                 195                 200                 205

 tct cac tta cag aga ctc atc ctg acc ccc ttg tca gcc ctg ctg tcc      673
 Ser His Leu Gln Arg Leu Ile Leu Thr Pro Leu Ser Ala Leu Leu Ser
                 210                 215                 220

 tta ttc cca ggg cct cac aag ctc atc cag aaa cgc tat gac aaa ctg      721
 Leu Phe Pro Gly Pro His Lys Leu Ile Gln Lys Arg Tyr Asp Lys Leu
             225                 230                 235

 ctg gat tgc aac agc tac ctg cag cga tca acg gga gag gag tca gac      769
 Leu Asp Cys Asn Ser Tyr Leu Gln Arg Ser Thr Gly Glu Glu Ser Asp
         240                 245                 250

 ttg gcc aaa aag gag tat gag gcc ctc aac gcc cag ctt gtg gag gag      817
 Leu Ala Lys Lys Glu Tyr Glu Ala Leu Asn Ala Gln Leu Val Glu Glu
     255                 260                 265

 ctc cag gca ttc aac cag gct gct cgg aag att ctg ttg aac tgt cta      865
 Leu Gln Ala Phe Asn Gln Ala Ala Arg Lys Ile Leu Leu Asn Cys Leu
 270                 275                 280                 285

 tgc agc ttc att acc ctc ctt agg gac ctg atg ctc gtg gca cag cag      913
 Cys Ser Phe Ile Thr Leu Leu Arg Asp Leu Met Leu Val Ala Gln Gln
                 290                 295                 300

 gct tac tcc aca ctt gtg ccg atg cca ctg ttg gtt tca agc att tct      961
 Ala Tyr Ser Thr Leu Val Pro Met Pro Leu Leu Val Ser Ser Ile Ser
             305                 310                 315

 gag att cag aat caa gta cta gaa gag atc caa aat ttg aat tgt gtg     1009
 Glu Ile Gln Asn Gln Val Leu Glu Glu Ile Gln Asn Leu Asn Cys Val
         320                 325                 330

 aaa gaa aac agt gcc acc ttt att gag agg aaa ctc agt ttt gaa aag     1057
 Lys Glu Asn Ser Ala Thr Phe Ile Glu Arg Lys Leu Ser Phe Glu Lys
     335                 340                 345

 aag aaa cct gtg cag att ctg cca gaa atg cca cat caa act gac att     1105
 Lys Lys Pro Val Gln Ile Leu Pro Glu Met Pro His Gln Thr Asp Ile
 350                 355                 360                 365

 cat cgc tcc aaa ctt cta tcc aca tat agt gca gag gaa ctc tat caa     1153
 His Arg Ser Lys Leu Leu Ser Thr Tyr Ser Ala Glu Glu Leu Tyr Gln
                 370                 375                 380

 gct aag cgc aag tgc aat gct aca caa gaa tat gac atc aat ctt ctg     1201
 Ala Lys Arg Lys Cys Asn Ala Thr Gln Glu Tyr Asp Ile Asn Leu Leu
             385                 390                 395

 gaa gga gac ttg gtg gct gtg ata gaa cag aaa gat cca ctg ggg agt     1249
 Glu Gly Asp Leu Val Ala Val Ile Glu Gln Lys Asp Pro Leu Gly Ser
         400                 405                 410

 aca agc agg tgg ctt gtg gac aca gga aat gtg aaa gga tat gtt tat     1297
 Thr Ser Arg Trp Leu Val Asp Thr Gly Asn Val Lys Gly Tyr Val Tyr
     415                 420                 425

 tcc tcc ttc cta aaa ccc tac aat cca gca aaa atg cag aaa gtg gat     1345
 Ser Ser Phe Leu Lys Pro Tyr Asn Pro Ala Lys Met Gln Lys Val Asp
 430                 435                 440                 445

 gct gag aac agg ttc tgt gac gat gat ttt gag aac atc agc ctc ttc     1393
 Ala Glu Asn Arg Phe Cys Asp Asp Asp Phe Glu Asn Ile Ser Leu Phe
                 450                 455                 460

 gtg tct tca cgg cca gct agt gac agt gtc aca ggc acc tca gaa agc     1441
 Val Ser Ser Arg Pro Ala Ser Asp Ser Val Thr Gly Thr Ser Glu Ser
             465                 470                 475

 agc att ggt gat agc agc tca tct ctt agt ggc aca tgt gga aag ttt     1489
 Ser Ile Gly Asp Ser Ser Ser Ser Leu Ser Gly Thr Cys Gly Lys Phe
         480                 485                 490

 gaa aca aat ggt act gat gtt gac agt ttt caa gaa gta gac gaa cag     1537
 Glu Thr Asn Gly Thr Asp Val Asp Ser Phe Gln Glu Val Asp Glu Gln
     495                 500                 505

 att ttc tat gca gtt cat gct ttt caa gca cgg agt gac cat gaa ctc     1585
 Ile Phe Tyr Ala Val His Ala Phe Gln Ala Arg Ser Asp His Glu Leu
 510                 515                 520                 525

 agc ctt cag gaa tac cag aga gtt cat ata ctc agg ttt tgt gac cta     1633
 Ser Leu Gln Glu Tyr Gln Arg Val His Ile Leu Arg Phe Cys Asp Leu
                 530                 535                 540

 agt ggc aat aaa gag tgg tgg tta gct gaa gct caa ggg cag aaa gga     1681
 Ser Gly Asn Lys Glu Trp Trp Leu Ala Glu Ala Gln Gly Gln Lys Gly
             545                 550                 555

 tac gtg cca gct aac tac ctt gga aag atg act tat gct taa gaaaata     1730
 Tyr Val Pro Ala Asn Tyr Leu Gly Lys Met Thr Tyr Ala 
         560                 565                 570

 agccttctac ttttattttc cagcaagttg ttgattcact acctcataaa actgacatta   1790

 caaaactttg gaccagaaag caagaaacct ctgaactaca gaaactgata ctgtactgg    1849




      <210> 530
      <211> 377
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (101)..(370)

      <400> 530
 cggtttttgt agcgacggtt tctctagccg ggcctgttct gtgctatcac ctcccccagg     60

 aaaccgttgc agttgggcag cccccttttt cacgggaacc  atg tgc gac cga aag     115
                                              Met Cys Asp Arg Lys
                                                1               5

 gcc ggg atc aaa aat gcg gac atg tcg gaa gaa atg ctt cag gac tcg      163
 Ala Gly Ile Lys Asn Ala Asp Met Ser Glu Glu Met Leu Gln Asp Ser
                  10                  15                  20

 gtg gat tgc gct act cag gcg ctg gag aat tac cac ata aaa aaa gaa      211
 Val Asp Cys Ala Thr Gln Ala Leu Glu Asn Tyr His Ile Lys Lys Glu
              25                  30                  35

 att ggg gct cat atc agg aag gaa ttt gac aag aag tac cat ccc acc      259
 Ile Gly Ala His Ile Arg Lys Glu Phe Asp Lys Lys Tyr His Pro Thr
          40                  45                  50

 tgg cgt tgg gtc aag ggg agg aac ttc ggt agt tat gtg aca cat gaa      307
 Trp Arg Trp Val Lys Gly Arg Asn Phe Gly Ser Tyr Val Thr His Glu
      55                  60                  65

 acc aaa cac ttc atc tac ttt tac ctg ggg caa ggg ggc att ctt ttg      355
 Thr Lys His Phe Ile Tyr Phe Tyr Leu Gly Gln Gly Gly Ile Leu Leu
  70                  75                  80                  85

 ttc aaa ttt gga taa aagcatg                                          377
 Phe Lys Phe Gly 






      <210> 531
      <211> 773
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (262)..(417)

      <400> 531
 aaggtagggt gggtgggagc caaacagaag gcttggaaac catttctgtg ctctttgccc     60

 agcaaaggga gcatgcagat ggcgagttaa catacctagg aggctcccct ggggtttaat    120

 gttgcattgt gtaccctcag aacgactgct cagcaaaggc aaaataaaca catttcctgt    180

 gcttcccttt ctcagctccg cagccctgcc aaagtggggg tgggagggtc acatcattta    240

 tttacacaag gtcctcttta t  atg gac acc tcc aat aac gtt att cat cgg     291
                          Met Asp Thr Ser Asn Asn Val Ile His Arg
                            1               5                  10

 gtt ggc tcc tcc agg gct gcc cca ctg ttc cca gca ggc cag gag tgt      339
 Val Gly Ser Ser Arg Ala Ala Pro Leu Phe Pro Ala Gly Gln Glu Cys
                  15                  20                  25

 gac ttc acg gtg aag cgt cac gtc caa gtt act ctg tac gtg gca atg      387
 Asp Phe Thr Val Lys Arg His Val Gln Val Thr Leu Tyr Val Ala Met
              30                  35                  40

 cca gct acc cac aag aaa gga ggg ctg tga a gggggagctg gggccgctcc      438
 Pro Ala Thr His Lys Lys Gly Gly Leu 
          45                  50

 tgggtaatgg atttcccccg cccccatttc tggcaaagag ctctgtggtc acagaattaa    498

 aaaaatctat caattgtaag ataaggcaca tgctgggtgt aagtgagagt gagggaacct    558

 attcttatct ctagctctga ggtaagatag aaatgtctgg aagctccccg cttgcagctg    618

 ggaactgtgc cttagtcatc tttatgtttc catggctttg cgcaaagtag gtgctcagaa    678

 aatgcttgtt caataagcaa accacaagga cacatactca cacacacaca cacacacaca    738

 cactcattgt gttgaaaatt gtaaaatcgt gagtt                               773




      <210> 532
      <211> 3893
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (405)..(3503)

      <400> 532
 aaatccacca cctcccgtag ccaaccaggc tcgactcact ctacagttgc acctgccagc     60

 accaacacgc cagtccttag tgaggtatct actacagtcc acagcagccc aggtgcaact    120

 ggaacagcac tcttccctac ccgctctgca acctcagtac ttgttggaga acctacaacg    180

 tcacccgatg agttcaggct caacggaaac aacagcgtta cctggcagta ccacaacagc    240

 aggcctgagt gagaaatgta ccactcttct acagtagccc cagatcaccg gacacaacac    300

 tctcacctgc cagcacgaca agctcaggcg tcagtgaaga atccaccacc tcccacagcc    360

 gaccaggctc aacgcacaca acagcattcc ctggcagtac cacc atg cca ggc gtc     416
                                                  Met Pro Gly Val
                                                    1

 agt cag gaa tct aca gct tcc cac agc agc cca ggc tcc aca gac aca      464
 Ser Gln Glu Ser Thr Ala Ser His Ser Ser Pro Gly Ser Thr Asp Thr
   5                  10                  15                  20

 aca ctg tcc cct ggc agt acc aca gca tca tcc ctt ggt cca gaa tct      512
 Thr Leu Ser Pro Gly Ser Thr Thr Ala Ser Ser Leu Gly Pro Glu Ser
                  25                  30                  35

 act acc ttc cac agc ggc cca ggc tcc act gaa aca aca ctc tta cct      560
 Thr Thr Phe His Ser Gly Pro Gly Ser Thr Glu Thr Thr Leu Leu Pro
              40                  45                  50

 gac aac acc aca gcc tca ggc ctc ctt gaa gca tct acg ccc gtc cac      608
 Asp Asn Thr Thr Ala Ser Gly Leu Leu Glu Ala Ser Thr Pro Val His
          55                  60                  65

 agc agc act gga tcg cca cac aca aca ctg tcc cct gcc ggc tct aca      656
 Ser Ser Thr Gly Ser Pro His Thr Thr Leu Ser Pro Ala Gly Ser Thr
      70                  75                  80

 acc cgt cag gga gaa tct acc acc ttc cag agc tgg cct aac tcg aag      704
 Thr Arg Gln Gly Glu Ser Thr Thr Phe Gln Ser Trp Pro Asn Ser Lys
  85                  90                  95                 100

 gac act acc cct gca cct cct act acc aca tca gcc ttt gtt gag cta      752
 Asp Thr Thr Pro Ala Pro Pro Thr Thr Thr Ser Ala Phe Val Glu Leu
                 105                 110                 115

 tct aca acc tcc cac ggc agc ccg agc tca act cca aca acc cac ttt      800
 Ser Thr Thr Ser His Gly Ser Pro Ser Ser Thr Pro Thr Thr His Phe
             120                 125                 130

 tct gcc agc tcc aca acc ttg ggc cgt agt gag gaa tcg aca aca gtc      848
 Ser Ala Ser Ser Thr Thr Leu Gly Arg Ser Glu Glu Ser Thr Thr Val
         135                 140                 145

 cac agc agc cca gtt gca act gca aca aca ccc tcg cct gcc cgc tcc      896
 His Ser Ser Pro Val Ala Thr Ala Thr Thr Pro Ser Pro Ala Arg Ser
     150                 155                 160

 aca acc tca ggc ctc gtt gaa gaa tct acg acc tac cac agc agc ccg      944
 Thr Thr Ser Gly Leu Val Glu Glu Ser Thr Thr Tyr His Ser Ser Pro
 165                 170                 175                 180

 ggc tca act caa aca atg cac ttc cct gaa agc gac aca act tca ggc      992
 Gly Ser Thr Gln Thr Met His Phe Pro Glu Ser Asp Thr Thr Ser Gly
                 185                 190                 195

 cgt ggt gaa gaa tca aca act tcc cac agc agc aca aca cac aca ata     1040
 Arg Gly Glu Glu Ser Thr Thr Ser His Ser Ser Thr Thr His Thr Ile
             200                 205                 210

 tct tca gct cct agc acc aca tct gcc ctt gtt gaa gaa cct acc agc     1088
 Ser Ser Ala Pro Ser Thr Thr Ser Ala Leu Val Glu Glu Pro Thr Ser
         215                 220                 225

 tac cac agc agc ccg ggc tca act gca aca aca cac ttc cct gac agc     1136
 Tyr His Ser Ser Pro Gly Ser Thr Ala Thr Thr His Phe Pro Asp Ser
     230                 235                 240

 tcc aca acc tca ggc cgt agt gag gaa tca aca gca tcc cac agc agc     1184
 Ser Thr Thr Ser Gly Arg Ser Glu Glu Ser Thr Ala Ser His Ser Ser
 245                 250                 255                 260

 caa gac gca acg gga aca ata gtc cta cct gcc cgc tcc aca acc tca     1232
 Gln Asp Ala Thr Gly Thr Ile Val Leu Pro Ala Arg Ser Thr Thr Ser
                 265                 270                 275

 gtt ctt ctt gga gaa tct acg acc tca ccc atc agt tca ggc tca atg     1280
 Val Leu Leu Gly Glu Ser Thr Thr Ser Pro Ile Ser Ser Gly Ser Met
             280                 285                 290

 gaa acg aca gcg tta ccc ggc agt acc aca acg cca ggc ctc agt gag     1328
 Glu Thr Thr Ala Leu Pro Gly Ser Thr Thr Thr Pro Gly Leu Ser Glu
         295                 300                 305

 aaa tct acc act ttc cac agt agc ccc aga tca cca gcc aca aca ctc     1376
 Lys Ser Thr Thr Phe His Ser Ser Pro Arg Ser Pro Ala Thr Thr Leu
     310                 315                 320

 tca cct gcc agc acg aca agc tca ggc gtc agt gaa gaa tcc acc acc     1424
 Ser Pro Ala Ser Thr Thr Ser Ser Gly Val Ser Glu Glu Ser Thr Thr
 325                 330                 335                 340

 tcc cac agc cga cca ggc tca acg cac aca aca gca ttc cct gac agc     1472
 Ser His Ser Arg Pro Gly Ser Thr His Thr Thr Ala Phe Pro Asp Ser
                 345                 350                 355

 acc acc acg cca ggc ctc agt cgg cat tct aca act tcc cac agc agc     1520
 Thr Thr Thr Pro Gly Leu Ser Arg His Ser Thr Thr Ser His Ser Ser
             360                 365                 370

 cca ggc tca acg gat aca aca ctg tta cct gcc agc acc acc acc tca     1568
 Pro Gly Ser Thr Asp Thr Thr Leu Leu Pro Ala Ser Thr Thr Thr Ser
         375                 380                 385

 ggc ccc agt cag gaa tca aca act tcc cac agc agc cca ggt tca act     1616
 Gly Pro Ser Gln Glu Ser Thr Thr Ser His Ser Ser Pro Gly Ser Thr
     390                 395                 400

 gac aca gca ctg tcc cct ggc agt acc aca gcc tta tcc ttt ggt caa     1664
 Asp Thr Ala Leu Ser Pro Gly Ser Thr Thr Ala Leu Ser Phe Gly Gln
 405                 410                 415                 420

 gaa tct aca acc ttc cac agc agc cca ggc tcc act cac aca aca ctc     1712
 Glu Ser Thr Thr Phe His Ser Ser Pro Gly Ser Thr His Thr Thr Leu
                 425                 430                 435

 ttc cct gac agc acc aca agc tca ggc atc gtt gaa gca tct aca cgc     1760
 Phe Pro Asp Ser Thr Thr Ser Ser Gly Ile Val Glu Ala Ser Thr Arg
             440                 445                 450

 gtc cac agc agc act ggc tca cca cgc aca aca ctg tcc cct gcc agc     1808
 Val His Ser Ser Thr Gly Ser Pro Arg Thr Thr Leu Ser Pro Ala Ser
         455                 460                 465

 tcc aca agc cct gga ctt cag gga gaa tct acc gcc ttc cag acc cac     1856
 Ser Thr Ser Pro Gly Leu Gln Gly Glu Ser Thr Ala Phe Gln Thr His
     470                 475                 480

 cca gcc tca act cac acg acg cct tca cct cct agc acc gca aca gcc     1904
 Pro Ala Ser Thr His Thr Thr Pro Ser Pro Pro Ser Thr Ala Thr Ala
 485                 490                 495                 500

 cct gtt gaa gaa tct aca acc tac cac cgc agc cca ggc tcg act cca     1952
 Pro Val Glu Glu Ser Thr Thr Tyr His Arg Ser Pro Gly Ser Thr Pro
                 505                 510                 515

 aca aca cac ttc cct gcc agc tcc aca act tcg ggc cac agt gag aaa     2000
 Thr Thr His Phe Pro Ala Ser Ser Thr Thr Ser Gly His Ser Glu Lys
             520                 525                 530

 tca aca ata ttc cac agc agc cca gat gca agt gga aca aca ccc tca     2048
 Ser Thr Ile Phe His Ser Ser Pro Asp Ala Ser Gly Thr Thr Pro Ser
         535                 540                 545

 tct gcc cac tcc aca acc tca ggt cgt gga gaa tct aca acc tca cgc     2096
 Ser Ala His Ser Thr Thr Ser Gly Arg Gly Glu Ser Thr Thr Ser Arg
     550                 555                 560

 atc agt cca ggc tca act gaa ata aca acg tta cct ggc agt acc aca     2144
 Ile Ser Pro Gly Ser Thr Glu Ile Thr Thr Leu Pro Gly Ser Thr Thr
 565                 570                 575                 580

 aca cca ggc ctc agt gag gca tct acc acc ttc tac agc agc ccc aga     2192
 Thr Pro Gly Leu Ser Glu Ala Ser Thr Thr Phe Tyr Ser Ser Pro Arg
                 585                 590                 595

 tca cca acc aca aca ctc tca cct gcc agc atg aca agc cta ggc gtc     2240
 Ser Pro Thr Thr Thr Leu Ser Pro Ala Ser Met Thr Ser Leu Gly Val
             600                 605                 610

 ggt gaa gaa tcc acc acc tcc cgt agc caa cca ggt tct act cac tca     2288
 Gly Glu Glu Ser Thr Thr Ser Arg Ser Gln Pro Gly Ser Thr His Ser
         615                 620                 625

 aca gtg tca cct gcc agc acc acc acg cca ggc ctc agt gag gaa tct     2336
 Thr Val Ser Pro Ala Ser Thr Thr Thr Pro Gly Leu Ser Glu Glu Ser
     630                 635                 640

 acc acc gtc tac agc agc agc cca ggc tca act gaa acc aca gtg ttc     2384
 Thr Thr Val Tyr Ser Ser Ser Pro Gly Ser Thr Glu Thr Thr Val Phe
 645                 650                 655                 660

 cct cgc agc acc aca acc tca gtt cgt ggt gaa gag cct aca acc ttc     2432
 Pro Arg Ser Thr Thr Thr Ser Val Arg Gly Glu Glu Pro Thr Thr Phe
                 665                 670                 675

 cac agc cgg cca gcc tca act cac aca aca ctg ttc act gag gac agc     2480
 His Ser Arg Pro Ala Ser Thr His Thr Thr Leu Phe Thr Glu Asp Ser
             680                 685                 690

 acc acc tcg ggc ctc act gaa gaa tct aca gcc ttc ccc ggc agc cca     2528
 Thr Thr Ser Gly Leu Thr Glu Glu Ser Thr Ala Phe Pro Gly Ser Pro
         695                 700                 705

 gcc tcc acc caa aca ggg tta cct gcc aca ctc aca acc gca gac ctc     2576
 Ala Ser Thr Gln Thr Gly Leu Pro Ala Thr Leu Thr Thr Ala Asp Leu
     710                 715                 720

 ggt gag gaa tca act acc ttt ccc agc agc tca ggc tca act gga aca     2624
 Gly Glu Glu Ser Thr Thr Phe Pro Ser Ser Ser Gly Ser Thr Gly Thr
 725                 730                 735                 740

 aca ctc tca cct gcc cgc tcc acc acc tct ggc ctc gtt gga gaa tcc     2672
 Thr Leu Ser Pro Ala Arg Ser Thr Thr Ser Gly Leu Val Gly Glu Ser
                 745                 750                 755

 aca ccc tca cgc ctc agt cca agc tca acc gaa aca aca act tta ccc     2720
 Thr Pro Ser Arg Leu Ser Pro Ser Ser Thr Glu Thr Thr Thr Leu Pro
             760                 765                 770

 ggc agt ccc aca aca cca agc ctc agt gag aaa tca acc acc ttc tac     2768
 Gly Ser Pro Thr Thr Pro Ser Leu Ser Glu Lys Ser Thr Thr Phe Tyr
         775                 780                 785

 act agc ccc aga tca cca gat gca aca ctc tca cct gca acc aca aca     2816
 Thr Ser Pro Arg Ser Pro Asp Ala Thr Leu Ser Pro Ala Thr Thr Thr
     790                 795                 800

 agc tca ggc gtc agc gaa gaa tcc agc aca tcc cac agt caa cca ggc     2864
 Ser Ser Gly Val Ser Glu Glu Ser Ser Thr Ser His Ser Gln Pro Gly
 805                 810                 815                 820

 tca acg cac aca aca gcg ttc cct gac agc acc acc acc tca ggc ctc     2912
 Ser Thr His Thr Thr Ala Phe Pro Asp Ser Thr Thr Thr Ser Gly Leu
                 825                 830                 835

 agt cag gaa cct aca act tcc cac agc agc caa ggc tca aca gag gca     2960
 Ser Gln Glu Pro Thr Thr Ser His Ser Ser Gln Gly Ser Thr Glu Ala
             840                 845                 850

 aca ctg tcc cct ggc agt acc aca gcc tca tcc ctt ggt caa caa tct     3008
 Thr Leu Ser Pro Gly Ser Thr Thr Ala Ser Ser Leu Gly Gln Gln Ser
         855                 860                 865

 aca acc ttc cac agc agc cca ggc gac act gaa acc aca ctc tta cct     3056
 Thr Thr Phe His Ser Ser Pro Gly Asp Thr Glu Thr Thr Leu Leu Pro
     870                 875                 880

 gac gac acc ata acc tca ggc ctc gtg gag gca tct aca ccc acc cac     3104
 Asp Asp Thr Ile Thr Ser Gly Leu Val Glu Ala Ser Thr Pro Thr His
 885                 890                 895                 900

 agc agc act ggc tcg cta cac aca aca ctg acc cct gcc agc tcc aca     3152
 Ser Ser Thr Gly Ser Leu His Thr Thr Leu Thr Pro Ala Ser Ser Thr
                 905                 910                 915

 agc gct ggc ctt cag gaa gaa tct acc act ttc cag agc tgg cca agc     3200
 Ser Ala Gly Leu Gln Glu Glu Ser Thr Thr Phe Gln Ser Trp Pro Ser
             920                 925                 930

 tca agt gac aca aca cct tca cct ccc ggc acc aca gca gcc cct gtt     3248
 Ser Ser Asp Thr Thr Pro Ser Pro Pro Gly Thr Thr Ala Ala Pro Val
         935                 940                 945

 gaa gta tcc aca acc tac cac agc cgc ccg agc tca act cca aca aca     3296
 Glu Val Ser Thr Thr Tyr His Ser Arg Pro Ser Ser Thr Pro Thr Thr
     950                 955                 960

 cac ttt tct gcc agt tcc aca acc ttg ggc cgt agt gag gaa tca aca     3344
 His Phe Ser Ala Ser Ser Thr Thr Leu Gly Arg Ser Glu Glu Ser Thr
 965                 970                 975                 980

 aca gtc cac agc agc cca ggt gca act gga aca gca ctc ttc cct acc     3392
 Thr Val His Ser Ser Pro Gly Ala Thr Gly Thr Ala Leu Phe Pro Thr
                 985                 990                 995

 cgc tct gca acc tca gta ctt gtt gga gaa cct aca atg tca ccc cat     3440
 Arg Ser Ala Thr Ser Val Leu Val Gly Glu Pro Thr Met Ser Pro His
            1000                1005                1010

 cag ttc agg ctc aac gga aac aac agc gtt acc tgg cag tac cac tac     3488
 Gln Phe Arg Leu Asn Gly Asn Asn Ser Val Thr Trp Gln Tyr His Tyr
        1015                1020                1025

 agc agg cct gag tga gaaatctacc accttctaca gtagccccag atcaccggac     3543
 Ser Arg Pro Glu 
    1030

 acaacactct cacctgccag cacgacaagc tcaggcgtca gtgaagaatc caccaccgcc   3603

 cacagccgac caggctcaac gcacacaacg catgtacctg gcagtaccac catgccaggc   3663

 gtcagtcagg aatctacagc ttcccacagc agcccaggct ccacagacac aacattgtcc   3723

 cctggcagta ccacagcatc atcccttggt ccagaatcta ctaccttcca cagcggccca   3783

 ggctccactg acacaacact cttacctgac agcaccacag gctcaggcct cgttgaagca   3843

 tctacacgcg tccacagcag cactggctca ccacacacaa cactgtcccc              3893




      <210> 533
      <211> 3809
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (405)..(3419)

      <400> 533
 aaatccacca cctcccgtag ccaaccaggc tcgactcact ctacagttgc acctgccagc     60

 accaacacgc cagtccttag tgaggtatct actacagtcc acagcagccc aggtgcaact    120

 ggaacagcac tcttccctac ccgctctgca acctcagtac ttgttggaga acctacaacg    180

 tcacccgatg agttcaggct caacggaaac aacagcgtta cctggcagta ccacaacagc    240

 aggcctgagt gagaaatgta ccactcttct acagtagccc cagatcaccg gacacaacac    300

 tctcacctgc cagcacgaca agctcaggcg tcagtgaaga atccaccacc tcccacagcc    360

 gaccaggctc aacgcacaca acagcattcc ctggcagtac cacc atg cca ggc gtc     416
                                                  Met Pro Gly Val
                                                    1

 agt cag gaa tct aca gct tcc cac agc agc cca ggc tcc aca gac aca      464
 Ser Gln Glu Ser Thr Ala Ser His Ser Ser Pro Gly Ser Thr Asp Thr
   5                  10                  15                  20

 aca ctg tcc cct ggc agt acc aca gca tca tcc ctt ggt cca gaa tct      512
 Thr Leu Ser Pro Gly Ser Thr Thr Ala Ser Ser Leu Gly Pro Glu Ser
                  25                  30                  35

 act acc ttc cac agc ggc cca ggc tcc act gaa aca aca ctc tta cct      560
 Thr Thr Phe His Ser Gly Pro Gly Ser Thr Glu Thr Thr Leu Leu Pro
              40                  45                  50

 gac aac acc aca gcc tca ggc ctc ctt gaa gca tct acg ccc gtc cac      608
 Asp Asn Thr Thr Ala Ser Gly Leu Leu Glu Ala Ser Thr Pro Val His
          55                  60                  65

 agc agc act gga tcg cca cac aca aca ctg tcc cct gcc ggc tct aca      656
 Ser Ser Thr Gly Ser Pro His Thr Thr Leu Ser Pro Ala Gly Ser Thr
      70                  75                  80

 acc cgt cag gga gaa tct acc acc ttc cag agc tgg cct aac tcg aag      704
 Thr Arg Gln Gly Glu Ser Thr Thr Phe Gln Ser Trp Pro Asn Ser Lys
  85                  90                  95                 100

 gac act acc cct gca cct cct act acc aca tca gcc ttt gtt gag cta      752
 Asp Thr Thr Pro Ala Pro Pro Thr Thr Thr Ser Ala Phe Val Glu Leu
                 105                 110                 115

 tct aca acc tcc cac ggc agc ccg agc tca act cca aca acc cac ttt      800
 Ser Thr Thr Ser His Gly Ser Pro Ser Ser Thr Pro Thr Thr His Phe
             120                 125                 130

 tct gcc agc tcc aca acc ttg ggc cgt agt gag gaa tcg aca aca gtc      848
 Ser Ala Ser Ser Thr Thr Leu Gly Arg Ser Glu Glu Ser Thr Thr Val
         135                 140                 145

 cac agc agc cca gtt gca act gca aca aca ccc tcg cct gcc cgc tcc      896
 His Ser Ser Pro Val Ala Thr Ala Thr Thr Pro Ser Pro Ala Arg Ser
     150                 155                 160

 aca acc tca ggc ctc gtt gaa gaa tct acg acc tac cac agc agc ccg      944
 Thr Thr Ser Gly Leu Val Glu Glu Ser Thr Thr Tyr His Ser Ser Pro
 165                 170                 175                 180

 ggc tca act caa aca atg cac ttc cct gaa agc gac aca act tca ggc      992
 Gly Ser Thr Gln Thr Met His Phe Pro Glu Ser Asp Thr Thr Ser Gly
                 185                 190                 195

 cgt ggt gaa gaa tca aca act tcc cac agc agc aca aca cac aca ata     1040
 Arg Gly Glu Glu Ser Thr Thr Ser His Ser Ser Thr Thr His Thr Ile
             200                 205                 210

 tct tca gct cct agc acc aca tct gcc ctt gtt gaa gaa cct acc agc     1088
 Ser Ser Ala Pro Ser Thr Thr Ser Ala Leu Val Glu Glu Pro Thr Ser
         215                 220                 225

 tac cac agc agc ccg ggc tca act gca aca aca cac ttc cct gac agc     1136
 Tyr His Ser Ser Pro Gly Ser Thr Ala Thr Thr His Phe Pro Asp Ser
     230                 235                 240

 tcc aca acc tca ggc cgt agt gag gaa tca aca gca tcc cac agc agc     1184
 Ser Thr Thr Ser Gly Arg Ser Glu Glu Ser Thr Ala Ser His Ser Ser
 245                 250                 255                 260

 caa gac gca acg gga aca ata gtc cta cct gcc cgc tcc aca acc tca     1232
 Gln Asp Ala Thr Gly Thr Ile Val Leu Pro Ala Arg Ser Thr Thr Ser
                 265                 270                 275

 gtt ctt ctt gga gaa tct acg acc tca ccc atc agt tca ggc tca atg     1280
 Val Leu Leu Gly Glu Ser Thr Thr Ser Pro Ile Ser Ser Gly Ser Met
             280                 285                 290

 gaa acg aca gcg tta ccc ggc agt acc aca acg cca ggc ctc agt gag     1328
 Glu Thr Thr Ala Leu Pro Gly Ser Thr Thr Thr Pro Gly Leu Ser Glu
         295                 300                 305

 aaa tct acc act ttc cac agt agc ccc aga tca cca gcc aca aca ctc     1376
 Lys Ser Thr Thr Phe His Ser Ser Pro Arg Ser Pro Ala Thr Thr Leu
     310                 315                 320

 tca cct gcc agc acg aca agc tca ggc gtc agt gaa gaa tcc acc acc     1424
 Ser Pro Ala Ser Thr Thr Ser Ser Gly Val Ser Glu Glu Ser Thr Thr
 325                 330                 335                 340

 tcc cac agc cga cca ggc tca acg cac aca aca gca ttc cct gac agc     1472
 Ser His Ser Arg Pro Gly Ser Thr His Thr Thr Ala Phe Pro Asp Ser
                 345                 350                 355

 acc acc acg cca ggc ctc agt cag gaa tca aca act tcc cac agc agc     1520
 Thr Thr Thr Pro Gly Leu Ser Gln Glu Ser Thr Thr Ser His Ser Ser
             360                 365                 370

 cca ggt tca act gac aca gca ctg tcc cct ggc agt acc aca gcc tta     1568
 Pro Gly Ser Thr Asp Thr Ala Leu Ser Pro Gly Ser Thr Thr Ala Leu
         375                 380                 385

 tcc ttt ggt caa gaa tct aca acc ttc cac agc agc cca ggc tcc act     1616
 Ser Phe Gly Gln Glu Ser Thr Thr Phe His Ser Ser Pro Gly Ser Thr
     390                 395                 400

 cac aca aca ctc ttc cct gac agc acc aca agc tca ggc atc gtt gaa     1664
 His Thr Thr Leu Phe Pro Asp Ser Thr Thr Ser Ser Gly Ile Val Glu
 405                 410                 415                 420

 gca tct aca cgc gtc cac agc agc act ggc tca cca cgc aca aca ctg     1712
 Ala Ser Thr Arg Val His Ser Ser Thr Gly Ser Pro Arg Thr Thr Leu
                 425                 430                 435

 tcc cct gcc agc tcc aca agc cct gga ctt cag gga gaa tct acc gcc     1760
 Ser Pro Ala Ser Ser Thr Ser Pro Gly Leu Gln Gly Glu Ser Thr Ala
             440                 445                 450

 ttc cag acc cac cca gcc tca act cac acg acg cct tca cct cct agc     1808
 Phe Gln Thr His Pro Ala Ser Thr His Thr Thr Pro Ser Pro Pro Ser
         455                 460                 465

 acc gca aca gcc cct gtt gaa gaa tct aca acc tac cac cgc agc cca     1856
 Thr Ala Thr Ala Pro Val Glu Glu Ser Thr Thr Tyr His Arg Ser Pro
     470                 475                 480

 ggc tcg act cca aca aca cac ttc cct gcc agc tcc aca act tcg ggc     1904
 Gly Ser Thr Pro Thr Thr His Phe Pro Ala Ser Ser Thr Thr Ser Gly
 485                 490                 495                 500

 cac agt gag aaa tca aca ata ttc cac agc agc cca gat gca agt gga     1952
 His Ser Glu Lys Ser Thr Ile Phe His Ser Ser Pro Asp Ala Ser Gly
                 505                 510                 515

 aca aca ccc tca tct gcc cac tcc aca acc tca ggt cgt gga gaa tct     2000
 Thr Thr Pro Ser Ser Ala His Ser Thr Thr Ser Gly Arg Gly Glu Ser
             520                 525                 530

 aca acc tca cgc atc agt cca ggc tca act gaa ata aca acg tta cct     2048
 Thr Thr Ser Arg Ile Ser Pro Gly Ser Thr Glu Ile Thr Thr Leu Pro
         535                 540                 545

 ggc agt acc aca aca cca ggc ctc agt gag gca tct acc acc ttc tac     2096
 Gly Ser Thr Thr Thr Pro Gly Leu Ser Glu Ala Ser Thr Thr Phe Tyr
     550                 555                 560

 agc agc ccc aga tca cca acc aca aca ctc tca cct gcc agc atg aca     2144
 Ser Ser Pro Arg Ser Pro Thr Thr Thr Leu Ser Pro Ala Ser Met Thr
 565                 570                 575                 580

 agc cta ggc gtc ggt gaa gaa tcc acc acc tcc cgt agc caa cca ggt     2192
 Ser Leu Gly Val Gly Glu Glu Ser Thr Thr Ser Arg Ser Gln Pro Gly
                 585                 590                 595

 tct act cac tca aca gtg tca cct gcc agc acc acc acg cca ggc ctc     2240
 Ser Thr His Ser Thr Val Ser Pro Ala Ser Thr Thr Thr Pro Gly Leu
             600                 605                 610

 agt gag gaa tct acc acc gtc tac agc agc agc cca ggc tca act gaa     2288
 Ser Glu Glu Ser Thr Thr Val Tyr Ser Ser Ser Pro Gly Ser Thr Glu
         615                 620                 625

 acc aca gtg ttc cct cgc agc acc aca acc tca gtt cgt ggt gaa gag     2336
 Thr Thr Val Phe Pro Arg Ser Thr Thr Thr Ser Val Arg Gly Glu Glu
     630                 635                 640

 cct aca acc ttc cac agc cgg cca gcc tca act cac aca aca ctg ttc     2384
 Pro Thr Thr Phe His Ser Arg Pro Ala Ser Thr His Thr Thr Leu Phe
 645                 650                 655                 660

 act gag gac agc acc acc tcg ggc ctc act gaa gaa tct aca gcc ttc     2432
 Thr Glu Asp Ser Thr Thr Ser Gly Leu Thr Glu Glu Ser Thr Ala Phe
                 665                 670                 675

 ccc ggc agc cca gcc tcc acc caa aca ggg tta cct gcc aca ctc aca     2480
 Pro Gly Ser Pro Ala Ser Thr Gln Thr Gly Leu Pro Ala Thr Leu Thr
             680                 685                 690

 acc gca gac ctc ggt gag gaa tca act acc ttt ccc agc agc tca ggc     2528
 Thr Ala Asp Leu Gly Glu Glu Ser Thr Thr Phe Pro Ser Ser Ser Gly
         695                 700                 705

 tca act gga aca aca ctc tca cct gcc cgc tcc acc acc tct ggc ctc     2576
 Ser Thr Gly Thr Thr Leu Ser Pro Ala Arg Ser Thr Thr Ser Gly Leu
     710                 715                 720

 gtt gga gaa tcc aca ccc tca cgc ctc agt cca agc tca acc gaa aca     2624
 Val Gly Glu Ser Thr Pro Ser Arg Leu Ser Pro Ser Ser Thr Glu Thr
 725                 730                 735                 740

 aca act tta ccc ggc agt ccc aca aca cca agc ctc agt gag aaa tca     2672
 Thr Thr Leu Pro Gly Ser Pro Thr Thr Pro Ser Leu Ser Glu Lys Ser
                 745                 750                 755

 acc acc ttc tac act agc ccc aga tca cca gat gca aca ctc tca cct     2720
 Thr Thr Phe Tyr Thr Ser Pro Arg Ser Pro Asp Ala Thr Leu Ser Pro
             760                 765                 770

 gca acc aca aca agc tca ggc gtc agc gaa gaa tcc agc aca tcc cac     2768
 Ala Thr Thr Thr Ser Ser Gly Val Ser Glu Glu Ser Ser Thr Ser His
         775                 780                 785

 agt caa cca ggc tca acg cac aca aca gcg ttc cct gac agc acc acc     2816
 Ser Gln Pro Gly Ser Thr His Thr Thr Ala Phe Pro Asp Ser Thr Thr
     790                 795                 800

 acc tca ggc ctc agt cag gaa cct aca act tcc cac agc agc caa ggc     2864
 Thr Ser Gly Leu Ser Gln Glu Pro Thr Thr Ser His Ser Ser Gln Gly
 805                 810                 815                 820

 tca aca gag gca aca ctg tcc cct ggc agt acc aca gcc tca tcc ctt     2912
 Ser Thr Glu Ala Thr Leu Ser Pro Gly Ser Thr Thr Ala Ser Ser Leu
                 825                 830                 835

 ggt caa caa tct aca acc ttc cac agc agc cca ggc gac act gaa acc     2960
 Gly Gln Gln Ser Thr Thr Phe His Ser Ser Pro Gly Asp Thr Glu Thr
             840                 845                 850

 aca ctc tta cct gac gac acc ata acc tca ggc ctc gtg gag gca tct     3008
 Thr Leu Leu Pro Asp Asp Thr Ile Thr Ser Gly Leu Val Glu Ala Ser
         855                 860                 865

 aca ccc acc cac agc agc act ggc tcg cta cac aca aca ctg acc cct     3056
 Thr Pro Thr His Ser Ser Thr Gly Ser Leu His Thr Thr Leu Thr Pro
     870                 875                 880

 gcc agc tcc aca agc gct ggc ctt cag gaa gaa tct acc act ttc cag     3104
 Ala Ser Ser Thr Ser Ala Gly Leu Gln Glu Glu Ser Thr Thr Phe Gln
 885                 890                 895                 900

 agc tgg cca agc tca agt gac aca aca cct tca cct ccc ggc acc aca     3152
 Ser Trp Pro Ser Ser Ser Asp Thr Thr Pro Ser Pro Pro Gly Thr Thr
                 905                 910                 915

 gca gcc cct gtt gaa gta tcc aca acc tac cac agc cgc ccg agc tca     3200
 Ala Ala Pro Val Glu Val Ser Thr Thr Tyr His Ser Arg Pro Ser Ser
             920                 925                 930

 act cca aca aca cac ttt tct gcc agt tcc aca acc ttg ggc cgt agt     3248
 Thr Pro Thr Thr His Phe Ser Ala Ser Ser Thr Thr Leu Gly Arg Ser
         935                 940                 945

 gag gaa tca aca aca gtc cac agc agc cca ggt gca act gga aca gca     3296
 Glu Glu Ser Thr Thr Val His Ser Ser Pro Gly Ala Thr Gly Thr Ala
     950                 955                 960

 ctc ttc cct acc cgc tct gca acc tca gta ctt gtt gga gaa cct aca     3344
 Leu Phe Pro Thr Arg Ser Ala Thr Ser Val Leu Val Gly Glu Pro Thr
 965                 970                 975                 980

 atg tca ccc cat cag ttc agg ctc aac gga aac aac agc gtt acc tgg     3392
 Met Ser Pro His Gln Phe Arg Leu Asn Gly Asn Asn Ser Val Thr Trp
                 985                 990                 995

 cag tac cac tac agc agg cct gag tga gaaat ctaccacctt ctacagtagc     3444
 Gln Tyr His Tyr Ser Arg Pro Glu 
            1000

 cccagatcac cggacacaac actctcacct gccagcacga caagctcagg cgtcagtgaa   3504

 gaatccacca ccgcccacag ccgaccaggc tcaacgcaca caacgcatgt acctggcagt   3564

 accaccatgc caggcgtcag tcaggaatct acagcttccc acagcagccc aggctccaca   3624

 gacacaacat tgtcccctgg cagtaccaca gcatcatccc ttggtccaga atctactacc   3684

 ttccacagcg gcccaggctc cactgacaca acactcttac ctgacagcac cacaggctca   3744

 ggcctcgttg aagcatctac acgcgtccac agcagcactg gctcaccaca cacaacactg   3804

 tcccc                                                               3809




      <210> 534
      <211> 953
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (352)..(822)

      <400> 534
 ggagcttggt ccagtgaaga gggaacagca cggggaacag cgtgtgtgag ggtcccgcca     60

 tgtctcagcc ctttcctggc ccccgcactt agccttcggt gcccatcttc agggtcaggg    120

 gaagcccagg ccaaagcggg ccgggaaggg gccctgtgga taaggccgag agcctgtccc    180

 aaaatagggc cggcaggatt tcccacccat aaaaggctct tggaatctgg accccgggga    240

 ccccaggcag ccaggcccag ctaaaactca gctgccacca ctgccccagc actctgccca    300

 cagcagccct ggtgtcacca ccctgcagaa tcctgtcaga caaccaccga c atg aca     357
                                                          Met Thr
                                                            1

 gag cgc ctg tcg gct gag cag atc aag gag tac aag gga gtc ttt gag      405
 Glu Arg Leu Ser Ala Glu Gln Ile Lys Glu Tyr Lys Gly Val Phe Glu
           5                  10                  15

 atg ttc gac gaa gag ggc aac ggg gag gtg aag acg ggg gag ctg gag      453
 Met Phe Asp Glu Glu Gly Asn Gly Glu Val Lys Thr Gly Glu Leu Glu
      20                  25                  30

 tgg ctc atg agc ctg ctg ggt atc aac ccc acc aag agt gag ctg gcc      501
 Trp Leu Met Ser Leu Leu Gly Ile Asn Pro Thr Lys Ser Glu Leu Ala
  35                  40                  45                  50

 tca atg gcc aag gat gtg gac aga gac aac aaa ggg ttc ttc aac tgc      549
 Ser Met Ala Lys Asp Val Asp Arg Asp Asn Lys Gly Phe Phe Asn Cys
                  55                  60                  65

 gat ggt ttc ctg gca cta atg gga gtt tac cat gag aag gcc cag aac      597
 Asp Gly Phe Leu Ala Leu Met Gly Val Tyr His Glu Lys Ala Gln Asn
              70                  75                  80

 cag gag agc gag ctg agg gcg gca ttc cgt gtc ttt gac aaa gag ggc      645
 Gln Glu Ser Glu Leu Arg Ala Ala Phe Arg Val Phe Asp Lys Glu Gly
          85                  90                  95

 aag ggc tac att gac tgg aac aca ctc aag tac gtg cta atg aac gca      693
 Lys Gly Tyr Ile Asp Trp Asn Thr Leu Lys Tyr Val Leu Met Asn Ala
     100                 105                 110

 ggg gag ccc ctc aac gag gtg gag gcg gag cag atg atg aag gag gcc      741
 Gly Glu Pro Leu Asn Glu Val Glu Ala Glu Gln Met Met Lys Glu Ala
 115                 120                 125                 130

 gac aag gat ggg gac agg acc atc gac tat gag gag ttt gtg gcc atg      789
 Asp Lys Asp Gly Asp Arg Thr Ile Asp Tyr Glu Glu Phe Val Ala Met
                 135                 140                 145

 atg acg ggg gag tcc ttc aag ctg atc cag tag gtgcacgt gccgcagccg      840
 Met Thr Gly Glu Ser Phe Lys Leu Ile Gln 
             150                 155

 ggggaggcct gcccgggaag gctgctgccc ctgccccctg gcccccactc ccccggctcc    900

 gtgtaaaata aatgttccag cccgaaaaaa aaaaaaaaaa aaaaaaaaaa tat           953




      <210> 535
      <211> 685
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (311)..(685)

      <220>
      <221> misc_feature
      <222> (1)...(685)
      <223> n = a,t,c or g

      <400> 535
 ccaaaccaag ganccataga aaagacccaa aaaccatgtc ccaggagaaa cagtagcaag     60

 gaaaccagga aaancctgtc ctacaggccc caccagaaga gctagagact ccaccccctt    120

 atgttcctat ttacctatct ctgacaagac ttaggaagac actccagcag ctgtctccgg    180

 agggtcagac tcagagaaga gtacccccca aacttcacta tgtagggaag agccagggcc    240

 actgcctgat aaatcaaagg aggaaatcca ggatgaggtt ggccatctcc ggtcaggacg    300

 cggccgagac   atg cag atg ccc gtc aga gaa act agg cga cag atc tat     349
              Met Gln Met Pro Val Arg Glu Thr Arg Arg Gln Ile Tyr
                1               5                  10

 tta gat gca caa aat gag gtt caa gga gga gaa tgg ctt tat gtt tat      397
 Leu Asp Ala Gln Asn Glu Val Gln Gly Gly Glu Trp Leu Tyr Val Tyr
      15                  20                  25

 cag ccc ttc tct act aca gac att ttc aac tgt aaa cag cat act ccc      445
 Gln Pro Phe Ser Thr Thr Asp Ile Phe Asn Cys Lys Gln His Thr Pro
  30                  35                  40                  45

 tcc tat acg gaa aaa ccc cag gct ctt att gac cta atg ctg tcc atc      493
 Ser Tyr Thr Glu Lys Pro Gln Ala Leu Ile Asp Leu Met Leu Ser Ile
                  50                  55                  60

 ttc tta act cac agc cca acc tgg gct gac tgc aag cag ctc ctt ctg      541
 Phe Leu Thr His Ser Pro Thr Trp Ala Asp Cys Lys Gln Leu Leu Leu
              65                  70                  75

 tca ctg ttc aat aca gaa gaa cgc tgc aga gta ata caa gtg gct aat      589
 Ser Leu Phe Asn Thr Glu Glu Arg Cys Arg Val Ile Gln Val Ala Asn
          80                  85                  90

 cag tgg cta gaa agc aac acc cca gta ggc atg gca gat gtc aaa cag      637
 Gln Trp Leu Glu Ser Asn Thr Pro Val Gly Met Ala Asp Val Lys Gln
      95                 100                 105

 tat gca caa cag act tta cca ata gaa act gat cca ggc tgg gac tga      685
 Tyr Ala Gln Gln Thr Leu Pro Ile Glu Thr Asp Pro Gly Trp Asp 
 110                 115                 120





      <210> 536
      <211> 1300
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (224)..(1300)

      <400> 536
 ctgcccatag gccagcaccg tggcattata gccctcgaag cagccctcga tgagcttgct     60

 cacacaggtg gaatagatct gttcttgcca ggtgtccagg tcgaagacaa agtcataggt    120

 gaaggccttg tccttcccca gcaggacctg gggctctccc ggggtaacag aggtacagat    180

 gtgacagccc tcaatcttct ccttcgacag ctggggccgg atc  atg gcc ggc cag     235
                                                  Met Ala Gly Gln
                                                    1

 ggg gac tgc tgc gtc aag gtg gcc gtc agg atc cgg ccc cag ctg tcg      283
 Gly Asp Cys Cys Val Lys Val Ala Val Arg Ile Arg Pro Gln Leu Ser
   5                  10                  15                  20

 aag gag aag att gag ggc tgt cac atc tgt acc tct gtt acc ccg gga      331
 Lys Glu Lys Ile Glu Gly Cys His Ile Cys Thr Ser Val Thr Pro Gly
                  25                  30                  35

 gag ccc cag gtc ctg ctg ggg aag gac aag gcc ttc acc tat gac ttt      379
 Glu Pro Gln Val Leu Leu Gly Lys Asp Lys Ala Phe Thr Tyr Asp Phe
              40                  45                  50

 gtc ttc gac ctg gac acc tgg caa gaa cag atc tat tcc acc tgt gtg      427
 Val Phe Asp Leu Asp Thr Trp Gln Glu Gln Ile Tyr Ser Thr Cys Val
          55                  60                  65

 agc aag ctc atc gag ggc tgc ttc gag ggc tat aat gcc acg gtg ctg      475
 Ser Lys Leu Ile Glu Gly Cys Phe Glu Gly Tyr Asn Ala Thr Val Leu
      70                  75                  80

 gcc tat ggg cag acg ggg gcc ggg aag acg tac acc atg ggc act ggc      523
 Ala Tyr Gly Gln Thr Gly Ala Gly Lys Thr Tyr Thr Met Gly Thr Gly
  85                  90                  95                 100

 ttt gac atg gca acg tcg gag gag gag cag ggc atc atc ccg agg gcc      571
 Phe Asp Met Ala Thr Ser Glu Glu Glu Gln Gly Ile Ile Pro Arg Ala
                 105                 110                 115

 atc gca cac ctc ttt ggg ggc att gcc gag cgc aag cgc cgg gca cag      619
 Ile Ala His Leu Phe Gly Gly Ile Ala Glu Arg Lys Arg Arg Ala Gln
             120                 125                 130

 gag cag ggc gtg gct gga cct gag ttc aaa gtc agc gcc cag ttt ctg      667
 Glu Gln Gly Val Ala Gly Pro Glu Phe Lys Val Ser Ala Gln Phe Leu
         135                 140                 145

 gag ctc tac aac gag gag atc ctt gac ctg ttt gac agc acc cgt gac      715
 Glu Leu Tyr Asn Glu Glu Ile Leu Asp Leu Phe Asp Ser Thr Arg Asp
     150                 155                 160

 cct gac acc cgc cac cgc agg tcc aac atc aag atc cac gag gac gca      763
 Pro Asp Thr Arg His Arg Arg Ser Asn Ile Lys Ile His Glu Asp Ala
 165                 170                 175                 180

 aac ggt ggc atc tac acc act ggc gtc act tct cgc ctc atc cac tcc      811
 Asn Gly Gly Ile Tyr Thr Thr Gly Val Thr Ser Arg Leu Ile His Ser
                 185                 190                 195

 cag gag gag ctg atc cag tgc ctg aag cag ggg gcc ctg tcc cgc acc      859
 Gln Glu Glu Leu Ile Gln Cys Leu Lys Gln Gly Ala Leu Ser Arg Thr
             200                 205                 210

 aca gcc agc acc cag atg aac gtg cag agc tca cgc tcc cac gcc atc      907
 Thr Ala Ser Thr Gln Met Asn Val Gln Ser Ser Arg Ser His Ala Ile
         215                 220                 225

 ttc acc atc cac ctg tgc cag atg cgc atg tgc acc cag ccc gac ctg      955
 Phe Thr Ile His Leu Cys Gln Met Arg Met Cys Thr Gln Pro Asp Leu
     230                 235                 240

 gtg aat gag gcg gtg act ggg ctt cct gat ggt aca cct ccc tcg agt     1003
 Val Asn Glu Ala Val Thr Gly Leu Pro Asp Gly Thr Pro Pro Ser Ser
 245                 250                 255                 260

 gag tat gag aca ctc act gct aag ttt cac ttt gtg gac ctg gcc ggc     1051
 Glu Tyr Glu Thr Leu Thr Ala Lys Phe His Phe Val Asp Leu Ala Gly
                 265                 270                 275

 tca gag cgg ctg aag cgg aca ggg gct act ggc gag cgg gcc aag gag     1099
 Ser Glu Arg Leu Lys Arg Thr Gly Ala Thr Gly Glu Arg Ala Lys Glu
             280                 285                 290

 ggc atc tcc atc aac tgt ggc ctg ctg gcc ttg ggc aat gtg atc agc     1147
 Gly Ile Ser Ile Asn Cys Gly Leu Leu Ala Leu Gly Asn Val Ile Ser
         295                 300                 305

 gcc tta ggg gac cag agc aag aag gtg gtg cac gtt ccc tac agg gac     1195
 Ala Leu Gly Asp Gln Ser Lys Lys Val Val His Val Pro Tyr Arg Asp
     310                 315                 320

 tcc aag ctc act cgg ctc ctc cag gat tcg ctg ggg ggc aac agg tat     1243
 Ser Lys Leu Thr Arg Leu Leu Gln Asp Ser Leu Gly Gly Asn Arg Tyr
 325                 330                 335                 340

 ctg gtg acc aac acc cag gga agg gac agg gga ggc agg gag gtt cct     1291
 Leu Val Thr Asn Thr Gln Gly Arg Asp Arg Gly Gly Arg Glu Val Pro
                 345                 350                 355

 gga aaa tag                                                         1300
 Gly Lys 






      <210> 537
      <211> 609
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (34)..(609)

      <400> 537
 caggatgatc ccaaggagca gaaggggcca gtg atg gct gcc atg ggg ggc ctc      54
                                      Met Ala Ala Met Gly Gly Leu
                                        1               5

 act gaa cca gtc cct acg ctg gac ctg ggc aag aag ctg agc gtg ccc      102
 Thr Glu Pro Val Pro Thr Leu Asp Leu Gly Lys Lys Leu Ser Val Pro
          10                  15                  20

 cag gac ctg atg atg gag gag ctg tca cta cgc aac aac aga ggg tcc      150
 Gln Asp Leu Met Met Glu Glu Leu Ser Leu Arg Asn Asn Arg Gly Ser
      25                  30                  35

 ctc ctc ttc cag aag agg cag cgc cgt gtg cag aag ttc act ttc gag      198
 Leu Leu Phe Gln Lys Arg Gln Arg Arg Val Gln Lys Phe Thr Phe Glu
  40                  45                  50                  55

 tta gca gcc agc cag cgg gcg gtg aat gct ggc cgg aag cgc cag gag      246
 Leu Ala Ala Ser Gln Arg Ala Val Asn Ala Gly Arg Lys Arg Gln Glu
                  60                  65                  70

 gaa ggt gac tgg aac agc gga gtc ggg gac ggc tat gcg gag ccg ctg      294
 Glu Gly Asp Trp Asn Ser Gly Val Gly Asp Gly Tyr Ala Glu Pro Leu
              75                  80                  85

 aag ggc gtc ccg cca gag aag ttc aac cac acc gcc atc tcc aag ggc      342
 Lys Gly Val Pro Pro Glu Lys Phe Asn His Thr Ala Ile Ser Lys Gly
          90                  95                 100

 tac cgc tgc cct tgg cag gag ttc gtc agc tac cgg gac tac cag agc      390
 Tyr Arg Cys Pro Trp Gln Glu Phe Val Ser Tyr Arg Asp Tyr Gln Ser
     105                 110                 115

 gat ggc cga agt cac acc ccc agc ccc aac gac tac cga aat ttc aac      438
 Asp Gly Arg Ser His Thr Pro Ser Pro Asn Asp Tyr Arg Asn Phe Asn
 120                 125                 130                 135

 aag acc ccg gtg cca ttt gga gga ccc ctc gtg ggg ggc act ttt ccc      486
 Lys Thr Pro Val Pro Phe Gly Gly Pro Leu Val Gly Gly Thr Phe Pro
                 140                 145                 150

 agg cca ggc acc ccc ttc atc ccg gag ccc ctc agt ggc ttg gaa ctc      534
 Arg Pro Gly Thr Pro Phe Ile Pro Glu Pro Leu Ser Gly Leu Glu Leu
             155                 160                 165

 ctc cgt ctc aga ccc agc ttc aac aga gtg gcc cag ggc tgg gtc cgt      582
 Leu Arg Leu Arg Pro Ser Phe Asn Arg Val Ala Gln Gly Trp Val Arg
         170                 175                 180

 aac ctc cca gag tcc gag gag ctg tag                                  609
 Asn Leu Pro Glu Ser Glu Glu Leu 
     185                 190





      <210> 538
      <211> 2051
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (181)..(1764)

      <400> 538
 aatttcgtgc gaggcggaaa atttcgaatg tggcggcggt agttccaggc gacggcggac     60

 ggtggtacgg tcctggaggg cccagtgcgc ggggctagcc gtggctggag agcttcgaag    120

 agccttgaaa tgtgaggagg aggaagatag ctgttgcaga agtagtggcc aaggcaaaag    180
                                                                 
 atg gcc aag gaa aga tgc ctg aaa aag tcc ttt caa gat agt ctt gaa      228
 Met Ala Lys Glu Arg Cys Leu Lys Lys Ser Phe Gln Asp Ser Leu Glu
   1               5                  10                  15

 gac ata aag aag cga atg aaa gag aaa agg aat aaa aac ttg gca gag      276
 Asp Ile Lys Lys Arg Met Lys Glu Lys Arg Asn Lys Asn Leu Ala Glu
              20                  25                  30

 att ggc aaa cgc agg tct ttt ata gct gca cca tgc caa ata atc acc      324
 Ile Gly Lys Arg Arg Ser Phe Ile Ala Ala Pro Cys Gln Ile Ile Thr
          35                  40                  45

 aac act tct aca ctg ctg aaa aat tac caa gac aac aac aaa atg tta      372
 Asn Thr Ser Thr Leu Leu Lys Asn Tyr Gln Asp Asn Asn Lys Met Leu
      50                  55                  60

 gtt tta gct ttg gaa aat gaa aaa tcc aaa gtg aaa gaa gcc caa gat      420
 Val Leu Ala Leu Glu Asn Glu Lys Ser Lys Val Lys Glu Ala Gln Asp
  65                  70                  75                  80

 atc atc cta cag ctg aga aaa gaa tgt tac tat ctc aca tgt cag cta      468
 Ile Ile Leu Gln Leu Arg Lys Glu Cys Tyr Tyr Leu Thr Cys Gln Leu
                  85                  90                  95

 tat gca ttg aaa gga aaa ctt aca tca caa caa aca gta gaa cct gct      516
 Tyr Ala Leu Lys Gly Lys Leu Thr Ser Gln Gln Thr Val Glu Pro Ala
             100                 105                 110

 cag aac cag gaa ata tgt tcc tct gga atg gac ccc aat agt gat gac      564
 Gln Asn Gln Glu Ile Cys Ser Ser Gly Met Asp Pro Asn Ser Asp Asp
         115                 120                 125

 agc tcc aga aat tta ttt gtg aag gat tta ccg caa att cct ctt gaa      612
 Ser Ser Arg Asn Leu Phe Val Lys Asp Leu Pro Gln Ile Pro Leu Glu
     130                 135                 140

 gaa act gaa ctt cca gga caa gga gaa tca ttt caa ata gaa gat cag      660
 Glu Thr Glu Leu Pro Gly Gln Gly Glu Ser Phe Gln Ile Glu Asp Gln
 145                 150                 155                 160

 ata cct act att cct caa gac aca ctg gga gtt gat ttt gat tca ggt      708
 Ile Pro Thr Ile Pro Gln Asp Thr Leu Gly Val Asp Phe Asp Ser Gly
                 165                 170                 175

 gaa gct aag tct act gat aat gtc tta cct aga act gta tct gtt cgt      756
 Glu Ala Lys Ser Thr Asp Asn Val Leu Pro Arg Thr Val Ser Val Arg
             180                 185                 190

 agc agt tta aag aaa cat tgt aac agt ata tgt cag ttt gat agc ttg      804
 Ser Ser Leu Lys Lys His Cys Asn Ser Ile Cys Gln Phe Asp Ser Leu
         195                 200                 205

 gat gat ttt gaa acc agt cat ttg gca ggg aag tct ttt gaa ttc gaa      852
 Asp Asp Phe Glu Thr Ser His Leu Ala Gly Lys Ser Phe Glu Phe Glu
     210                 215                 220

 aga gtt gga ttt tta gac cca cta gta aac atg cac ata cct gaa aat      900
 Arg Val Gly Phe Leu Asp Pro Leu Val Asn Met His Ile Pro Glu Asn
 225                 230                 235                 240

 gta caa cac aat gct tgt caa tgg agc aag gac caa gtt aac tta tca      948
 Val Gln His Asn Ala Cys Gln Trp Ser Lys Asp Gln Val Asn Leu Ser
                 245                 250                 255

 cca aag ctg att cag cca gga acg ttt act aaa aca aaa gaa gac att      996
 Pro Lys Leu Ile Gln Pro Gly Thr Phe Thr Lys Thr Lys Glu Asp Ile
             260                 265                 270

 tta gaa tct aaa tct gaa caa act aaa agt aag caa aga gat aca caa     1044
 Leu Glu Ser Lys Ser Glu Gln Thr Lys Ser Lys Gln Arg Asp Thr Gln
         275                 280                 285

 gaa aga aaa aga gaa gag aaa aga aaa gct aac agg aga aaa tca aaa     1092
 Glu Arg Lys Arg Glu Glu Lys Arg Lys Ala Asn Arg Arg Lys Ser Lys
     290                 295                 300

 cgt atg tca aaa tat aaa gag aat aaa agc gaa aat aaa aaa act gtt     1140
 Arg Met Ser Lys Tyr Lys Glu Asn Lys Ser Glu Asn Lys Lys Thr Val
 305                 310                 315                 320

 ccc caa aaa aaa atg cac aaa tct gtc agt tcc aat gat gct tac aat     1188
 Pro Gln Lys Lys Met His Lys Ser Val Ser Ser Asn Asp Ala Tyr Asn
                 325                 330                 335

 ttt aat ttg gaa gag ggt gtt cat ctt act cct ttc cga caa aaa gtg     1236
 Phe Asn Leu Glu Glu Gly Val His Leu Thr Pro Phe Arg Gln Lys Val
             340                 345                 350

 agc aat gac tct aat aga gaa gaa aac aac gag tct gaa gtg agc ctc     1284
 Ser Asn Asp Ser Asn Arg Glu Glu Asn Asn Glu Ser Glu Val Ser Leu
         355                 360                 365

 tgt gaa tca agt ggt tca gga gat gat tcc gat gac ctc tat ttg ccc     1332
 Cys Glu Ser Ser Gly Ser Gly Asp Asp Ser Asp Asp Leu Tyr Leu Pro
     370                 375                 380

 act tgc aag tac att cag aat ccc acg agc aat tca gat aga cca gtc     1380
 Thr Cys Lys Tyr Ile Gln Asn Pro Thr Ser Asn Ser Asp Arg Pro Val
 385                 390                 395                 400

 acc agg cct cta gct aaa aga gca ctg aaa tac aca gat gaa aaa gag     1428
 Thr Arg Pro Leu Ala Lys Arg Ala Leu Lys Tyr Thr Asp Glu Lys Glu
                 405                 410                 415

 acg gag ggt tct aag cca aca aaa act cct acc act aca cca cct gaa     1476
 Thr Glu Gly Ser Lys Pro Thr Lys Thr Pro Thr Thr Thr Pro Pro Glu
             420                 425                 430

 act cag cag tca cct cat ctt agc ctg aag gat atc acc aat gtc tcc     1524
 Thr Gln Gln Ser Pro His Leu Ser Leu Lys Asp Ile Thr Asn Val Ser
         435                 440                 445

 ttg tat cct gtt gtg aaa atc aga aga ctt tct ctt tct cca aaa aag     1572
 Leu Tyr Pro Val Val Lys Ile Arg Arg Leu Ser Leu Ser Pro Lys Lys
     450                 455                 460

 aat aaa gca agc cca gca gtg gct ctg cct aaa cgt agg tgc aca gcc     1620
 Asn Lys Ala Ser Pro Ala Val Ala Leu Pro Lys Arg Arg Cys Thr Ala
 465                 470                 475                 480

 agc gtg aac tat aag gag ccc acc ctc gct tcg aaa ctg aga aga ggg     1668
 Ser Val Asn Tyr Lys Glu Pro Thr Leu Ala Ser Lys Leu Arg Arg Gly
                 485                 490                 495

 gac cct ttt aca gat ttg tgt ttt ttg aat tct cct att ttc aag cag     1716
 Asp Pro Phe Thr Asp Leu Cys Phe Leu Asn Ser Pro Ile Phe Lys Gln
             500                 505                 510

 aaa aag gat ttg aga cgt tct aaa aaa agt atg aaa caa ata caa tga     1764
 Lys Lys Asp Leu Arg Arg Ser Lys Lys Ser Met Lys Gln Ile Gln 
         515                 520                 525

 aggttttgtt ggatattgtt taaattcaat ctacacctct ttctgttgct tcaggagagg   1824

 atctgtaaga gtacacaaac agagtgagcc attgccatag aatattctct tgacaggacc   1884

 ctagctcata aacatttctt cagaactata cttcaaatgg gatgctttgt attaaaactt   1944

 taataaattt aatttatttt ttcttttgaa tataaataac tgagcttaag cattatcatc   2004

 atatcgattt cttatgctgc ctaaacctct taattttagt cgaaata                 2051




      <210> 539
      <211> 968
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (201)..(968)

      <400> 539
 ccctgggaag gaagagccgc ggcgggattg gtctaggagg aggcctaggc ccgacctgcg     60

 gtggtgggtc ttgcctcgac ggggctgctt cgcgccctct cctctgctcc agcttcgccc    120

 acttctcctt gccagcgggc gaggcacagg ggagacctgc cggagccacg gaagatgagg    180

 tggcccgcag tgccaagaag    atg gac aag atg gtg cag gag aag aac acg     230
                          Met Asp Lys Met Val Gln Glu Lys Asn Thr
                            1               5                  10

 gcc gga gca ctg ggt ttg tta aca gag ctt cag aat gtt ctg gaa tta      278
 Ala Gly Ala Leu Gly Leu Leu Thr Glu Leu Gln Asn Val Leu Glu Leu
                  15                  20                  25

 ctg cgg tcc aca gga act gga atg tta ctt aat gtt agt ctc aag cag      326
 Leu Arg Ser Thr Gly Thr Gly Met Leu Leu Asn Val Ser Leu Lys Gln
              30                  35                  40

 agt gca gat gaa gaa gtt aca tct tta gca aag tct ctc gtc aaa tcc      374
 Ser Ala Asp Glu Glu Val Thr Ser Leu Ala Lys Ser Leu Val Lys Ser
          45                  50                  55

 tgg aaa aag tta cca gat aag cca tca agt gag aaa gac cct aaa gaa      422
 Trp Lys Lys Leu Pro Asp Lys Pro Ser Ser Glu Lys Asp Pro Lys Glu
      60                  65                  70

 aag caa ata gaa cct gca atg aca tcg cag aat agc aaa aga aac act      470
 Lys Gln Ile Glu Pro Ala Met Thr Ser Gln Asn Ser Lys Arg Asn Thr
  75                  80                  85                  90

 tct gat tct gtg cgg atg aag tac agg gag atg ctt cct gca gcc ctt      518
 Ser Asp Ser Val Arg Met Lys Tyr Arg Glu Met Leu Pro Ala Ala Leu
                  95                 100                 105

 cga aca gga gat gac tgc att gaa atg gga act gat gag gaa gaa tta      566
 Arg Thr Gly Asp Asp Cys Ile Glu Met Gly Thr Asp Glu Glu Glu Leu
             110                 115                 120

 gga tct cga act gag gaa gca ata gat cca gaa aga ggg aat aca ggc      614
 Gly Ser Arg Thr Glu Glu Ala Ile Asp Pro Glu Arg Gly Asn Thr Gly
         125                 130                 135

 atg aag tac aaa aat aga gtc caa agt aag ata tca aat ctt aca gat      662
 Met Lys Tyr Lys Asn Arg Val Gln Ser Lys Ile Ser Asn Leu Thr Asp
     140                 145                 150

 gca aag aat cca gat tta agg aaa aat gca ccg tgt ggg aat att cct      710
 Ala Lys Asn Pro Asp Leu Arg Lys Asn Ala Pro Cys Gly Asn Ile Pro
 155                 160                 165                 170

 cct gac tta ctt gct aga atg aca gca gaa gaa atg gct agt gat gag      758
 Pro Asp Leu Leu Ala Arg Met Thr Ala Glu Glu Met Ala Ser Asp Glu
                 175                 180                 185

 ctc aaa gag atg cac aaa aac ttg acg aaa gaa gcc atc aga gag cat      806
 Leu Lys Glu Met His Lys Asn Leu Thr Lys Glu Ala Ile Arg Glu His
             190                 195                 200

 cag atg gcc aag aca ggt gga acc cag cct gat tcg ctc aca tgt gcc      854
 Gln Met Ala Lys Thr Gly Gly Thr Gln Pro Asp Ser Leu Thr Cys Ala
         205                 210                 215

 aaa tgt aaa aag aag aat tgc act tcc aca cag gta caa gcc tgc agt      902
 Lys Cys Lys Lys Lys Asn Cys Thr Ser Thr Gln Val Gln Ala Cys Ser
     220                 225                 230

 gct ggt gaa cca atg aca acg ttt gtt gac tgt aat gaa tgt gga aat      950
 Ala Gly Glu Pro Met Thr Thr Phe Val Asp Cys Asn Glu Cys Gly Asn
 235                 240                 245                 250

 caa cag aag ttc tgt tga                                              968
 Gln Gln Lys Phe Cys 
                 255





      <210> 540
      <211> 1344
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (172)..(1344)

      <400> 540
 tttcgtctgg cgtggacgtt tgtggtgggg cgtgttggtc cgcgctctca gaactgtgct     60

 gggaaggatg gtagggcgac tggggctcac ctccgcaccg ttgtaggacc cggggtaggg    120

 ttttgagccc gtgggagctg ccccacgcgg cctcgtcctg ccaacggtcg g atg gcg     177
                                                          Met Ala
                                                            1

 gag acg aag gac gca gcg cag atg ttg gtg acc ttc aag gat gtg gct      225
 Glu Thr Lys Asp Ala Ala Gln Met Leu Val Thr Phe Lys Asp Val Ala
           5                  10                  15

 gtg acc ttt acc cgg gag gag tgg aga cag ctg gac ctg gcc cag agg      273
 Val Thr Phe Thr Arg Glu Glu Trp Arg Gln Leu Asp Leu Ala Gln Arg
      20                  25                  30

 acc ctg tac cga gag gtg atg ctg gag acc tgt ggg ctt ctg gtt tca      321
 Thr Leu Tyr Arg Glu Val Met Leu Glu Thr Cys Gly Leu Leu Val Ser
  35                  40                  45                  50

 cta ggt gac aga gca caa gtt cat acc aga gag cca acc act tac ccg      369
 Leu Gly Asp Arg Ala Gln Val His Thr Arg Glu Pro Thr Thr Tyr Pro
                  55                  60                  65

 cca gtc tta tct gag cgg gcc ttt ctc cgg gga agc ctg act ctg gaa      417
 Pro Val Leu Ser Glu Arg Ala Phe Leu Arg Gly Ser Leu Thr Leu Glu
              70                  75                  80

 tct tca acc tca agt gat tcg agg ttg ggg aga gct agg gat gag gaa      465
 Ser Ser Thr Ser Ser Asp Ser Arg Leu Gly Arg Ala Arg Asp Glu Glu
          85                  90                  95

 ggg ctt ttg gaa atg cag aaa ggt aaa gtg aca ccg gag aca gac ctc      513
 Gly Leu Leu Glu Met Gln Lys Gly Lys Val Thr Pro Glu Thr Asp Leu
     100                 105                 110

 cac aag gag acc cat ctt ggg aaa gtg agc ctt gaa ggt gaa ggt ttg      561
 His Lys Glu Thr His Leu Gly Lys Val Ser Leu Glu Gly Glu Gly Leu
 115                 120                 125                 130

 ggg aca gat gat ggt ctg cac tcc agg gca tta caa gag tgg tta tca      609
 Gly Thr Asp Asp Gly Leu His Ser Arg Ala Leu Gln Glu Trp Leu Ser
                 135                 140                 145

 gca gat gtt ctc cat gaa tgt gac tca cag caa cca ggg aaa gac gcc      657
 Ala Asp Val Leu His Glu Cys Asp Ser Gln Gln Pro Gly Lys Asp Ala
             150                 155                 160

 ttg att cat gca ggg aca aac ccc tac aaa tgc aag cag tgt ggg aaa      705
 Leu Ile His Ala Gly Thr Asn Pro Tyr Lys Cys Lys Gln Cys Gly Lys
         165                 170                 175

 ggt ttt aac agg aag tgg tat ctc gtt cga cat cag agg gtt cac act      753
 Gly Phe Asn Arg Lys Trp Tyr Leu Val Arg His Gln Arg Val His Thr
     180                 185                 190

 gga atg aaa ccc tat gaa tgc aat gca tgt ggg aaa gcc ttt agc cag      801
 Gly Met Lys Pro Tyr Glu Cys Asn Ala Cys Gly Lys Ala Phe Ser Gln
 195                 200                 205                 210

 agc tca act ctc att cgg cac tac ctc atc cac acc ggg gag aaa cca      849
 Ser Ser Thr Leu Ile Arg His Tyr Leu Ile His Thr Gly Glu Lys Pro
                 215                 220                 225

 tac aag tgc ctt gag tgt ggg aag gcc ttc aaa cgc agg tcg tac ctc      897
 Tyr Lys Cys Leu Glu Cys Gly Lys Ala Phe Lys Arg Arg Ser Tyr Leu
             230                 235                 240

 atg cag cac cat cca atc cac act gga gag aaa ccc tat gag tgt agt      945
 Met Gln His His Pro Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ser
         245                 250                 255

 caa tgt cga aag gcc ttc acc cac cgg tct act ttt att cgc cat aat      993
 Gln Cys Arg Lys Ala Phe Thr His Arg Ser Thr Phe Ile Arg His Asn
     260                 265                 270

 agg acc cac act gga gaa aag ccc ttt gag tgc aaa gaa tgt gag aaa     1041
 Arg Thr His Thr Gly Glu Lys Pro Phe Glu Cys Lys Glu Cys Glu Lys
 275                 280                 285                 290

 gcc ttt agc aat aga gcc cac cta att caa cat tac atc atc cac act     1089
 Ala Phe Ser Asn Arg Ala His Leu Ile Gln His Tyr Ile Ile His Thr
                 295                 300                 305

 gga gag aag ccc tat gat tgc atg gca tgt gga aag gcc ttc aga tgc     1137
 Gly Glu Lys Pro Tyr Asp Cys Met Ala Cys Gly Lys Ala Phe Arg Cys
             310                 315                 320

 agc tca gaa ctc ata cag cac cag cgg att cac act ggg gag aag ccc     1185
 Ser Ser Glu Leu Ile Gln His Gln Arg Ile His Thr Gly Glu Lys Pro
         325                 330                 335

 tat gaa tgc acc cag tgt ggg aaa gcc ttt cac cgg agc acg tac ctc     1233
 Tyr Glu Cys Thr Gln Cys Gly Lys Ala Phe His Arg Ser Thr Tyr Leu
     340                 345                 350

 att cag cac tct gtc atc cac act ggg gag atg ccc tac aag tgt atc     1281
 Ile Gln His Ser Val Ile His Thr Gly Glu Met Pro Tyr Lys Cys Ile
 355                 360                 365                 370

 gag tgt ggg aag gcc ttc aaa cgc agg tca cac ctt ctg cag cac caa     1329
 Glu Cys Gly Lys Ala Phe Lys Arg Arg Ser His Leu Leu Gln His Gln
                 375                 380                 385

 agg gtc cat aca tga                                                 1344
 Arg Val His Thr 
             390





      <210> 541
      <211> 597
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (247)..(597)

      <400> 541
 gtgaaagaaa agtaaaatct gtgcacattc ccacattcag agaatcattt gcatactaaa     60

 aaatgtatgt ttcctttcca gccttttgtc tatttatgag tacatacctt aaaaatgtct    120

 accatttgca tagcttttcc tagcgcttta taaagctccc tagatcctga gtactccccc    180

 gtgttagtga gttctttagt ggagtctgta ggttgctttc aattccgttt tacaggtaag    240

 actgtc   atg tac atc ctc agt gca caa atc cca tcc cac cag ctg ctt     288
          Met Tyr Ile Leu Ser Ala Gln Ile Pro Ser His Gln Leu Leu
            1               5                  10

 agg aca cat tcc cag aca gga ctg aag caa ttc acg ctg cta cag tcg      336
 Arg Thr His Ser Gln Thr Gly Leu Lys Gln Phe Thr Leu Leu Gln Ser
  15                  20                  25                  30

 ctg gtc atg cga agg gcc acc cca cag cac ttc act ggc gac tac tgc      384
 Leu Val Met Arg Arg Ala Thr Pro Gln His Phe Thr Gly Asp Tyr Cys
                  35                  40                  45

 gaa cac tgg cgg ccc cct cac ccc gtg ggc agc ctg tcg gca gct gct      432
 Glu His Trp Arg Pro Pro His Pro Val Gly Ser Leu Ser Ala Ala Ala
              50                  55                  60

 tac ctc ctt ccc ccc gac ttt gga gag ttc atc cag gta aat atc aat      480
 Tyr Leu Leu Pro Pro Asp Phe Gly Glu Phe Ile Gln Val Asn Ile Asn
          65                  70                  75

 gaa gtg gaa tct cac tcc att agg aga ctg act ctc agg aca cag gac      528
 Glu Val Glu Ser His Ser Ile Arg Arg Leu Thr Leu Arg Thr Gln Asp
      80                  85                  90

 ctc ctt cat cag gac atc caa gaa aac ctt gat tcg gct aaa gaa cca      576
 Leu Leu His Gln Asp Ile Gln Glu Asn Leu Asp Ser Ala Lys Glu Pro
  95                 100                 105                 110

 aac gca tgc ttc tgt gaa tga                                          597
 Asn Ala Cys Phe Cys Glu 
                 115





      <210> 542
      <211> 892
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (62)..(892)

      <400> 542
 aactgccagc tggccctccc agaacactcc atgccactgg aactcaggag cgcaggagct     60

 c    atg aaa gac ttc tta gag aag aga gac aag ggg aaa ctt ctc ata     106
      Met Lys Asp Phe Leu Glu Lys Arg Asp Lys Gly Lys Leu Leu Ile
        1               5                  10                  15

 cag aga agt aga aga cta aaa cag aat ctc ttg aga ccg atg caa ctt      154
 Gln Arg Ser Arg Arg Leu Lys Gln Asn Leu Leu Arg Pro Met Gln Leu
                  20                  25                  30

 tcc gta act gaa gat ggc tat att cat tac ggt gac aaa gtg atg ctt      202
 Ser Val Thr Glu Asp Gly Tyr Ile His Tyr Gly Asp Lys Val Met Leu
              35                  40                  45

 gtg aat cct gat gat cct gac aca gaa gct gat gtg ttt ctg cgt ggg      250
 Val Asn Pro Asp Asp Pro Asp Thr Glu Ala Asp Val Phe Leu Arg Gly
          50                  55                  60

 gac ctg agc ctg tgt atg act cca gat gaa att cag tcc cat ctg aaa      298
 Asp Leu Ser Leu Cys Met Thr Pro Asp Glu Ile Gln Ser His Leu Lys
      65                  70                  75

 gac gaa tta gag gta ccc tgt ggc ctg agc gca gtt caa gcc aag acc      346
 Asp Glu Leu Glu Val Pro Cys Gly Leu Ser Ala Val Gln Ala Lys Thr
  80                  85                  90                  95

 cca att ggc aga aac act ttt atc att ttg agt gta cac aga gat gcc      394
 Pro Ile Gly Arg Asn Thr Phe Ile Ile Leu Ser Val His Arg Asp Ala
                 100                 105                 110

 act ggt caa gtc ctt aga tat ggg cag gac ttt tgc ctg ggg ata aca      442
 Thr Gly Gln Val Leu Arg Tyr Gly Gln Asp Phe Cys Leu Gly Ile Thr
             115                 120                 125

 gga gga ttt gac aac aaa atg ttg tat ttg tca agt gac cac agg acc      490
 Gly Gly Phe Asp Asn Lys Met Leu Tyr Leu Ser Ser Asp His Arg Thr
         130                 135                 140

 ctc ctg aaa tcg tct aag agg tct tgg ctc cag gaa gtg tac cta aca      538
 Leu Leu Lys Ser Ser Lys Arg Ser Trp Leu Gln Glu Val Tyr Leu Thr
     145                 150                 155

 gat gag gtc tcc cat gtg aac tgc tgg cag gct gcc ttc cct gac ccc      586
 Asp Glu Val Ser His Val Asn Cys Trp Gln Ala Ala Phe Pro Asp Pro
 160                 165                 170                 175

 cag tta cgc ctg gaa tat gaa ggc ttc ccc gtc ccg gca aat gct aaa      634
 Gln Leu Arg Leu Glu Tyr Glu Gly Phe Pro Val Pro Ala Asn Ala Lys
                 180                 185                 190

 att ctc atc aat cac tgt cac aca aat cgg gga ctg gca gcc cac cgg      682
 Ile Leu Ile Asn His Cys His Thr Asn Arg Gly Leu Ala Ala His Arg
             195                 200                 205

 cat ctt ttc tta agc acc tat ttt gga aag gag gct gag gtt gta gct      730
 His Leu Phe Leu Ser Thr Tyr Phe Gly Lys Glu Ala Glu Val Val Ala
         210                 215                 220

 cac aca tac ctg gat tca cat aga gtt gag aaa cca agg aac cac tgg      778
 His Thr Tyr Leu Asp Ser His Arg Val Glu Lys Pro Arg Asn His Trp
     225                 230                 235

 atg ttg gtt act ggg aat ccc agg gat gcc tcg tcc tcc atg ttg gat      826
 Met Leu Val Thr Gly Asn Pro Arg Asp Ala Ser Ser Ser Met Leu Asp
 240                 245                 250                 255

 ctg ccc aaa cca ccc aca gag gac act cga gcc atg gag cag gcc atg      874
 Leu Pro Lys Pro Pro Thr Glu Asp Thr Arg Ala Met Glu Gln Ala Met
                 260                 265                 270

 ggc ctt gac acg cag taa                                              892
 Gly Leu Asp Thr Gln 
             275





      <210> 543
      <211> 968
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (60)..(968)

      <400> 543
 tagatgacaa aattcctaaa acattccaga attcccttat tcatcttgga ctcaacact      59                                                                 
 atg aag tct gca aat ata tgt ata ggt cga cca gtg ttg ctt act agt      107
 Met Lys Ser Ala Asn Ile Cys Ile Gly Arg Pro Val Leu Leu Thr Ser
   1               5                  10                  15

 ttg aac gga aag caa gag gtg tat aca gcc tgg cct atg gca gga ttt      155
 Leu Asn Gly Lys Gln Glu Val Tyr Thr Ala Trp Pro Met Ala Gly Phe
              20                  25                  30

 cct gga ggc aag gtc ggc ctg agt gaa atg gca cag aaa aat gtg ggt      203
 Pro Gly Gly Lys Val Gly Leu Ser Glu Met Ala Gln Lys Asn Val Gly
          35                  40                  45

 gtg agg cct ggt gat gcc atc cag gtc cag cct ctt gtg ggt gct gtg      251
 Val Arg Pro Gly Asp Ala Ile Gln Val Gln Pro Leu Val Gly Ala Val
      50                  55                  60

 cta cag gct gag gaa atg gat gtg gca ctg agt gac aaa gat atg gaa      299
 Leu Gln Ala Glu Glu Met Asp Val Ala Leu Ser Asp Lys Asp Met Glu
  65                  70                  75                  80

 att aat gaa gaa gaa ctg act ggt tgt atc ctg aga aaa cta gat ggc      347
 Ile Asn Glu Glu Glu Leu Thr Gly Cys Ile Leu Arg Lys Leu Asp Gly
                  85                  90                  95

 aag att gtt tta cca ggc aac ttt ctg tat tgt aca ttc tat gga cga      395
 Lys Ile Val Leu Pro Gly Asn Phe Leu Tyr Cys Thr Phe Tyr Gly Arg
             100                 105                 110

 ccg tac aag ctg caa gta ttg cga gtg aaa ggg gca gat ggc atg ata      443
 Pro Tyr Lys Leu Gln Val Leu Arg Val Lys Gly Ala Asp Gly Met Ile
         115                 120                 125

 ttg gga ggg cct cag agt gac tct gac act gat gcc caa aga atg gcc      491
 Leu Gly Gly Pro Gln Ser Asp Ser Asp Thr Asp Ala Gln Arg Met Ala
     130                 135                 140

 ttt gaa cag tcc agc atg gaa acc agt agc ctg gag tta tcc tta cag      539
 Phe Glu Gln Ser Ser Met Glu Thr Ser Ser Leu Glu Leu Ser Leu Gln
 145                 150                 155                 160

 cta agc cag tta gat ctg gag gat acc cag atc cca aca tca aga agt      587
 Leu Ser Gln Leu Asp Leu Glu Asp Thr Gln Ile Pro Thr Ser Arg Ser
                 165                 170                 175

 act cct tat aaa cca att gat gac aga att aca aat aaa gcc agt gat      635
 Thr Pro Tyr Lys Pro Ile Asp Asp Arg Ile Thr Asn Lys Ala Ser Asp
             180                 185                 190

 gtt ttg ctg gat gtt aca cag agc cct gga gat ggc agt gga ctt atg      683
 Val Leu Leu Asp Val Thr Gln Ser Pro Gly Asp Gly Ser Gly Leu Met
         195                 200                 205

 cta gag gaa gtc aca ggt ctt aaa tgt aat ttt gaa tct gcc aga gaa      731
 Leu Glu Glu Val Thr Gly Leu Lys Cys Asn Phe Glu Ser Ala Arg Glu
     210                 215                 220

 gga aat gag caa ctt act gaa gaa gag aga ctg cta aag ttc agc ata      779
 Gly Asn Glu Gln Leu Thr Glu Glu Glu Arg Leu Leu Lys Phe Ser Ile
 225                 230                 235                 240

 gga gca aag tgc aat act gat act ttt tat ttt att tct tca aca aca      827
 Gly Ala Lys Cys Asn Thr Asp Thr Phe Tyr Phe Ile Ser Ser Thr Thr
                 245                 250                 255

 aga gtc aat ttt aca gag att gat aaa aat tca aaa gag caa gac aac      875
 Arg Val Asn Phe Thr Glu Ile Asp Lys Asn Ser Lys Glu Gln Asp Asn
             260                 265                 270

 caa ttc aaa gta act tat gac atg ata gga gga tta agt agc cag ctg      923
 Gln Phe Lys Val Thr Tyr Asp Met Ile Gly Gly Leu Ser Ser Gln Leu
         275                 280                 285

 aaa gca att aga gaa ata att gaa ttg ccc ctc aaa aca gcc tga          968
 Lys Ala Ile Arg Glu Ile Ile Glu Leu Pro Leu Lys Thr Ala 
     290                 295                 300





      <210> 544
      <211> 1089
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1089)

      <400> 544
  atg aaa tac ctt act gtg gga gac tta gaa gat tgc cta ctg aat aag      48
  Met Lys Tyr Leu Thr Val Gly Asp Leu Glu Asp Cys Leu Leu Asn Lys
    1               5                  10                  15

 gtg gac ttg agg cgc cag cag att tcc cag gct gtg gag gag gtg cag       96
 Val Asp Leu Arg Arg Gln Gln Ile Ser Gln Ala Val Glu Glu Val Gln
              20                  25                  30

 aaa gtc gtt cat cat ttg acc aca aac atc agc aac caa gac att aga      144
 Lys Val Val His His Leu Thr Thr Asn Ile Ser Asn Gln Asp Ile Arg
          35                  40                  45

 ttt caa gct gtg cct tac tct gac acg tac aat gaa aat att aag gtt      192
 Phe Gln Ala Val Pro Tyr Ser Asp Thr Tyr Asn Glu Asn Ile Lys Val
      50                  55                  60

 ttg gct ccc agt cag ttc ctc gtc aca gtc cca ata aaa ggc ctg gcc      240
 Leu Ala Pro Ser Gln Phe Leu Val Thr Val Pro Ile Lys Gly Leu Ala
  65                  70                  75                  80

 ggg tac agg gag gcc agg gag cag cac tgg cgg tac tac aca ctg cag      288
 Gly Tyr Arg Glu Ala Arg Glu Gln His Trp Arg Tyr Tyr Thr Leu Gln
                  85                  90                  95

 ggc acc agg ctg ccc tgc ccg ttg cgg gac cct gag ggt ctg cag cag      336
 Gly Thr Arg Leu Pro Cys Pro Leu Arg Asp Pro Glu Gly Leu Gln Gln
             100                 105                 110

 tgg ctg gag gtg gaa cag ttt atg aag agc ctg tgg cag tgg cat gag      384
 Trp Leu Glu Val Glu Gln Phe Met Lys Ser Leu Trp Gln Trp His Glu
         115                 120                 125

 aca gat gtg aac atc gac gga gac att gtg cct gcc aag gtc ctc cta      432
 Thr Asp Val Asn Ile Asp Gly Asp Ile Val Pro Ala Lys Val Leu Leu
     130                 135                 140

 gtg ttc cgg aag ctg gtg gaa aat gca gtt aga acc tgt cac ctc tca      480
 Val Phe Arg Lys Leu Val Glu Asn Ala Val Arg Thr Cys His Leu Ser
 145                 150                 155                 160

 ggt aag gtc agc ctg cta gga aac cgc tct gca gtt tgg gtt gct gtg      528
 Gly Lys Val Ser Leu Leu Gly Asn Arg Ser Ala Val Trp Val Ala Val
                 165                 170                 175

 gaa aca tct gca tat cag gtg gaa ctg gag ctg gtc ccc gca gtg gag      576
 Glu Thr Ser Ala Tyr Gln Val Glu Leu Glu Leu Val Pro Ala Val Glu
             180                 185                 190

 atc ccc acc acc tgg tcc aag aaa gcc cgg tgg cct cga tgt ctg cag      624
 Ile Pro Thr Thr Trp Ser Lys Lys Ala Arg Trp Pro Arg Cys Leu Gln
         195                 200                 205

 cgc tgg cct tcc caa gag aga gtg gag tgc atc aag tcg ttt gga ttt      672
 Arg Trp Pro Ser Gln Glu Arg Val Glu Cys Ile Lys Ser Phe Gly Phe
     210                 215                 220

 aac ttg ttg gcc tgt tca aat tat cac tgg cag ctg agc ttc ctc cgt      720
 Asn Leu Leu Ala Cys Ser Asn Tyr His Trp Gln Leu Ser Phe Leu Arg
 225                 230                 235                 240

 gct gag cag gtg tta ctg gaa cag ctg gat gaa gat ggg ggc tgc cgt      768
 Ala Glu Gln Val Leu Leu Glu Gln Leu Asp Glu Asp Gly Gly Cys Arg
                 245                 250                 255

 agg aag tgt ttt cag gtc atg agg cac ctg aag gag gac atc tgg tgc      816
 Arg Lys Cys Phe Gln Val Met Arg His Leu Lys Glu Asp Ile Trp Cys
             260                 265                 270

 cca ggg aac agg ccg gtt atc acg tcc cac cat ctg cag act gtg ctc      864
 Pro Gly Asn Arg Pro Val Ile Thr Ser His His Leu Gln Thr Val Leu
         275                 280                 285

 ttt tgg acc tgc gag aaa tat ccc cac ttt aaa gac tgg cag gtc ttc      912
 Phe Trp Thr Cys Glu Lys Tyr Pro His Phe Lys Asp Trp Gln Val Phe
     290                 295                 300

 agc aaa gca ttt ctg cgc ctg gtg agg aaa ctg cac aag tgc gtg agc      960
 Ser Lys Ala Phe Leu Arg Leu Val Arg Lys Leu His Lys Cys Val Ser
 305                 310                 315                 320

 cag cac ttc ctg aaa cac tat ttc gtc cgg aac agc aac ctc ttt cag     1008
 Gln His Phe Leu Lys His Tyr Phe Val Arg Asn Ser Asn Leu Phe Gln
                 325                 330                 335

 tgc acc aac ccg act gaa ctg gac act gtg gcc caa aag ctg gcc acc     1056
 Cys Thr Asn Pro Thr Glu Leu Asp Thr Val Ala Gln Lys Leu Ala Thr
             340                 345                 350

 ttc ctg aag aac ccc cag atc ggc ccg ccc tga                         1089
 Phe Leu Lys Asn Pro Gln Ile Gly Pro Pro 
         355                 360





      <210> 545
      <211> 1398
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1398)

      <400> 545
  atg ttt cag ggt acc agg acc gag aga tcc acg gaa acc atg gag ttg      48
  Met Phe Gln Gly Thr Arg Thr Glu Arg Ser Thr Glu Thr Met Glu Leu
    1               5                  10                  15

 tgg ggc aca gcg aag aag ggg ttg cta aca gac cta aaa gaa gca tca       96
 Trp Gly Thr Ala Lys Lys Gly Leu Leu Thr Asp Leu Lys Glu Ala Ser
              20                  25                  30

 tgt tcc atg act tca ttt cac ccc agg gga ctt caa gct gcc cgt gcc      144
 Cys Ser Met Thr Ser Phe His Pro Arg Gly Leu Gln Ala Ala Arg Ala
          35                  40                  45

 cag aag ttc aag agt aaa agg cca cgg agt aac agt gat tgt ttt cag      192
 Gln Lys Phe Lys Ser Lys Arg Pro Arg Ser Asn Ser Asp Cys Phe Gln
      50                  55                  60

 gaa gag gat ctg agg cag ggt ttt cag tgg agg aag agc ctc cct ttt      240
 Glu Glu Asp Leu Arg Gln Gly Phe Gln Trp Arg Lys Ser Leu Pro Phe
  65                  70                  75                  80

 ggg gca gcc tca tct tac ttg aac ttg gag aag ctg ggt gaa ggc tct      288
 Gly Ala Ala Ser Ser Tyr Leu Asn Leu Glu Lys Leu Gly Glu Gly Ser
                  85                  90                  95

 tat gcg aca gtt tac aag ggg att agc aga ata aat gga caa cta gtg      336
 Tyr Ala Thr Val Tyr Lys Gly Ile Ser Arg Ile Asn Gly Gln Leu Val
             100                 105                 110

 gct tta aaa gtc atc agc atg aat gca gag gaa gga gtc cca ttt aca      384
 Ala Leu Lys Val Ile Ser Met Asn Ala Glu Glu Gly Val Pro Phe Thr
         115                 120                 125

 gct atc cga gaa gct tct ctc ctg aag ggt ttg aaa cat gcc aat att      432
 Ala Ile Arg Glu Ala Ser Leu Leu Lys Gly Leu Lys His Ala Asn Ile
     130                 135                 140

 gtg ctc ctg cat gac ata atc cac acc aaa gag aca ctg aca ttc gtt      480
 Val Leu Leu His Asp Ile Ile His Thr Lys Glu Thr Leu Thr Phe Val
 145                 150                 155                 160

 ttt gaa tac atg cac aca gac ctg gcc cag tat atg tct cag cat cca      528
 Phe Glu Tyr Met His Thr Asp Leu Ala Gln Tyr Met Ser Gln His Pro
                 165                 170                 175

 gga ggg ctt cat cct cat aat gtc aga ctt ttc atg ttt caa ctt ttg      576
 Gly Gly Leu His Pro His Asn Val Arg Leu Phe Met Phe Gln Leu Leu
             180                 185                 190

 cgg ggc ctg gcg tac atc cac cac caa cac gtt ctt cac agg gac ctg      624
 Arg Gly Leu Ala Tyr Ile His His Gln His Val Leu His Arg Asp Leu
         195                 200                 205

 aaa cct cag aac tta ctc atc agt cac ctg gga gag ctc aaa ctg gct      672
 Lys Pro Gln Asn Leu Leu Ile Ser His Leu Gly Glu Leu Lys Leu Ala
     210                 215                 220

 gat ttt ggt ctt gcc cgg gcc aag tcc att ccc agc cag aca tac tct      720
 Asp Phe Gly Leu Ala Arg Ala Lys Ser Ile Pro Ser Gln Thr Tyr Ser
 225                 230                 235                 240

 tca gaa gtc gtg acc ctc tgg tac cgg ccc cct gat gct ttg ctg gga      768
 Ser Glu Val Val Thr Leu Trp Tyr Arg Pro Pro Asp Ala Leu Leu Gly
                 245                 250                 255

 gcc act gaa tat tcc tct gag ctg gac ata tgg ggt gca ggc tgc atc      816
 Ala Thr Glu Tyr Ser Ser Glu Leu Asp Ile Trp Gly Ala Gly Cys Ile
             260                 265                 270

 ttt att gaa atg ttc cag ggt caa cct ttg ttt cct ggg gtt tcc aac      864
 Phe Ile Glu Met Phe Gln Gly Gln Pro Leu Phe Pro Gly Val Ser Asn
         275                 280                 285

 atc ctt gaa cag ctg gag aaa atc tgg gag gtg ctg gga gtc cct aca      912
 Ile Leu Glu Gln Leu Glu Lys Ile Trp Glu Val Leu Gly Val Pro Thr
     290                 295                 300

 gag gat act tgg ccg gga gtc tcc aag cta cct aac tac aat cca gaa      960
 Glu Asp Thr Trp Pro Gly Val Ser Lys Leu Pro Asn Tyr Asn Pro Glu
 305                 310                 315                 320

 tgg ttc cca ctg cct acg cct cga agc ctt cat gtt gtc tgg aac agg     1008
 Trp Phe Pro Leu Pro Thr Pro Arg Ser Leu His Val Val Trp Asn Arg
                 325                 330                 335

 ctg ggc agg gtt cct gaa gct gaa gac ctg gcc tcc cag atg cta aaa     1056
 Leu Gly Arg Val Pro Glu Ala Glu Asp Leu Ala Ser Gln Met Leu Lys
             340                 345                 350

 ggc ttt ccc aga gac cgc gtc tcc gcc cag gaa gca ctt gtt cat gat     1104
 Gly Phe Pro Arg Asp Arg Val Ser Ala Gln Glu Ala Leu Val His Asp
         355                 360                 365

 tat ttc agc gcc ctg cca tct cag ctg tac cag ctt cct gat ggt gag     1152
 Tyr Phe Ser Ala Leu Pro Ser Gln Leu Tyr Gln Leu Pro Asp Gly Glu
     370                 375                 380

 cga ggg agt gtg tgc gtg tgc gtg agt gca tgt gcc act ggt ggg gag     1200
 Arg Gly Ser Val Cys Val Cys Val Ser Ala Cys Ala Thr Gly Gly Glu
 385                 390                 395                 400

 agg tta caa gga cct ctt tgt aat ggt cca gac att tca cag gta cac     1248
 Arg Leu Gln Gly Pro Leu Cys Asn Gly Pro Asp Ile Ser Gln Val His
                 405                 410                 415

 att tac act cag aaa ttg gat gag atg gac gtt gtc tct gag ttg ttt     1296
 Ile Tyr Thr Gln Lys Leu Asp Glu Met Asp Val Val Ser Glu Leu Phe
             420                 425                 430

 gcc tta gct acc atc tgc cag gaa gcc aca cca gtg ttt cta aca aga     1344
 Ala Leu Ala Thr Ile Cys Gln Glu Ala Thr Pro Val Phe Leu Thr Arg
         435                 440                 445

 ctc ttc tcc ctt tct gcg gag agt aag atg ata ggt gaa gcg gat atg     1392
 Leu Phe Ser Leu Ser Ala Glu Ser Lys Met Ile Gly Glu Ala Asp Met
     450                 455                 460

 tcc tga                                                             1398
 Ser 
 465





      <210> 546
      <211> 1608
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1608)

      <400> 546
  atg gat cca tcg cct atg acg gtg atg tgt ctg ggc tct cac gag gct      48
  Met Asp Pro Ser Pro Met Thr Val Met Cys Leu Gly Ser His Glu Ala
    1               5                  10                  15

 aaa agc agc agc acg ggg gag cgt cct ctg tgg ggt cta aca ttc tgt       96
 Lys Ser Ser Ser Thr Gly Glu Arg Pro Leu Trp Gly Leu Thr Phe Cys
              20                  25                  30

 gtc ttc att cat aaa tat gaa tac att cta cat gac atc cgt ctt cag      144
 Val Phe Ile His Lys Tyr Glu Tyr Ile Leu His Asp Ile Arg Leu Gln
          35                  40                  45

 ttc atc ctt atc aac atg aag gga cca aat gag tac tta ctg ggc tct      192
 Phe Ile Leu Ile Asn Met Lys Gly Pro Asn Glu Tyr Leu Leu Gly Ser
      50                  55                  60

 tcc tgt gtt tta gac act ttc acg aac gtc ctg agg aag ctc ctg acg      240
 Ser Cys Val Leu Asp Thr Phe Thr Asn Val Leu Arg Lys Leu Leu Thr
  65                  70                  75                  80

 cag cca cag cag gct aaa gcg gac gtg ctg tcc ctg gag gag atc ctg      288
 Gln Pro Gln Gln Ala Lys Ala Asp Val Leu Ser Leu Glu Glu Ile Leu
                  85                  90                  95

 gcc gag ggt gtg gag gaa agt gat gcg tcg agc cag ggc agt ggc agc      336
 Ala Glu Gly Val Glu Glu Ser Asp Ala Ser Ser Gln Gly Ser Gly Ser
             100                 105                 110

 gag ggg ccc gtg cgg ctg agc cgg acc cgc acc aag gcc cta cag gag      384
 Glu Gly Pro Val Arg Leu Ser Arg Thr Arg Thr Lys Ala Leu Gln Glu
         115                 120                 125

 gcc atg tac tac agc gct gag cac ggc tac gtg gac atc acc atg gag      432
 Ala Met Tyr Tyr Ser Ala Glu His Gly Tyr Val Asp Ile Thr Met Glu
     130                 135                 140

 ctg agg gca ctg gga gtc ccc tgg aag ctg cac atc tgg atc gag tct      480
 Leu Arg Ala Leu Gly Val Pro Trp Lys Leu His Ile Trp Ile Glu Ser
 145                 150                 155                 160

 ctg agg acc tcg ttc tcg cag tcg cgg tac tcg gtg gtg cag agc ctc      528
 Leu Arg Thr Ser Phe Ser Gln Ser Arg Tyr Ser Val Val Gln Ser Leu
                 165                 170                 175

 ctg cgg gac ttc agc tcc atc aga gag gag gag tac aac gag gag ctg      576
 Leu Arg Asp Phe Ser Ser Ile Arg Glu Glu Glu Tyr Asn Glu Glu Leu
             180                 185                 190

 gtg acc gag ggc ttg cag ctc atg ttc gac atc ctc aag acc agc aaa      624
 Val Thr Glu Gly Leu Gln Leu Met Phe Asp Ile Leu Lys Thr Ser Lys
         195                 200                 205

 aac gac tcc gtc atc cag caa ctg gct acc atc ttc acc cac tgc tat      672
 Asn Asp Ser Val Ile Gln Gln Leu Ala Thr Ile Phe Thr His Cys Tyr
     210                 215                 220

 ggc agc agt ccc atc ccc agc atc cca gag atc cgg aag acc ctg ccg      720
 Gly Ser Ser Pro Ile Pro Ser Ile Pro Glu Ile Arg Lys Thr Leu Pro
 225                 230                 235                 240

 gcc agg cta gat cca cac ttt ttg aac aat aag gag atg tca gat gtg      768
 Ala Arg Leu Asp Pro His Phe Leu Asn Asn Lys Glu Met Ser Asp Val
                 245                 250                 255

 acc ttc ctg gtg gaa gga aag ctg ttt tat gca cat aaa gtc ctg ctg      816
 Thr Phe Leu Val Glu Gly Lys Leu Phe Tyr Ala His Lys Val Leu Leu
             260                 265                 270

 gtg aca gct tct aac agg ttc aag aca cta atg acc aat aaa tca gaa      864
 Val Thr Ala Ser Asn Arg Phe Lys Thr Leu Met Thr Asn Lys Ser Glu
         275                 280                 285

 cag gat ggg gac agc agc aag acc atc gag atc agc gac atg aag tac      912
 Gln Asp Gly Asp Ser Ser Lys Thr Ile Glu Ile Ser Asp Met Lys Tyr
     290                 295                 300

 cac att ttt cag atg atg atg cag tat ctg tac tac gga gga aca gaa      960
 His Ile Phe Gln Met Met Met Gln Tyr Leu Tyr Tyr Gly Gly Thr Glu
 305                 310                 315                 320

 tcc atg gag atc ccc acc gct gac atc ctg gag ctg ctg tca gct gcc     1008
 Ser Met Glu Ile Pro Thr Ala Asp Ile Leu Glu Leu Leu Ser Ala Ala
                 325                 330                 335

 agc ctg ttc cag ctg gat gcc ctg cag agg cac tgc gag atc ctg tgc     1056
 Ser Leu Phe Gln Leu Asp Ala Leu Gln Arg His Cys Glu Ile Leu Cys
             340                 345                 350

 tcc cag acc ctc agc atg gag agt gct gtg aac acc tac aaa tat gcc     1104
 Ser Gln Thr Leu Ser Met Glu Ser Ala Val Asn Thr Tyr Lys Tyr Ala
         355                 360                 365

 aag atc cac aat gcc cca gaa ctg gcc ctg ttc tgt gag ggc ttc ttc     1152
 Lys Ile His Asn Ala Pro Glu Leu Ala Leu Phe Cys Glu Gly Phe Phe
     370                 375                 380

 ctc aag cac atg aag gcc cta ctg gag cag gat gcc ttc cgg cag ctc     1200
 Leu Lys His Met Lys Ala Leu Leu Glu Gln Asp Ala Phe Arg Gln Leu
 385                 390                 395                 400

 atc tac ggc cgc agc agc aaa gtg cag ggc ctg gat cca ctg cag gac     1248
 Ile Tyr Gly Arg Ser Ser Lys Val Gln Gly Leu Asp Pro Leu Gln Asp
                 405                 410                 415

 ctg cag aac acc ctg gca gag cgc gtg cac tct gtc tac atc acc tcc     1296
 Leu Gln Asn Thr Leu Ala Glu Arg Val His Ser Val Tyr Ile Thr Ser
             420                 425                 430

 cgg gta ctc ctg ggc tgg gaa gcc cta gac aca ctg ctc acc ttt gac     1344
 Arg Val Leu Leu Gly Trp Glu Ala Leu Asp Thr Leu Leu Thr Phe Asp
         435                 440                 445

 ctt gat acc aac acc ttc caa att cca cca ggc agc caa gac cca cca     1392
 Leu Asp Thr Asn Thr Phe Gln Ile Pro Pro Gly Ser Gln Asp Pro Pro
     450                 455                 460

 gaa gaa acg tcc agc aag cat gct ccc cgg cct ttt gtt cca gtc aaa     1440
 Glu Glu Thr Ser Ser Lys His Ala Pro Arg Pro Phe Val Pro Val Lys
 465                 470                 475                 480

 gcc acc gtg ctc aag gcc aaa gcc atc atg ggc cct gtg cta cat ttg     1488
 Ala Thr Val Leu Lys Ala Lys Ala Ile Met Gly Pro Val Leu His Leu
                 485                 490                 495

 cca tac tgt aca aaa cag aga cag gtc aca ctg aca gtg ggc ttc tgt     1536
 Pro Tyr Cys Thr Lys Gln Arg Gln Val Thr Leu Thr Val Gly Phe Cys
             500                 505                 510

 gct gca cca caa agc atc tgg gaa atg agg ccg gca tcg atg ctg gat     1584
 Ala Ala Pro Gln Ser Ile Trp Glu Met Arg Pro Ala Ser Met Leu Asp
         515                 520                 525

 cct tca aga tgc cac agt gac taa                                     1608
 Pro Ser Arg Cys His Ser Asp 
     530                 535





      <210> 547
      <211> 2213
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (154)..(1536)

      <400> 547
 tgccctactg gccctacctc acagctgaaa ctttaaaaaa caggatgggc caccagccac     60

 ctcctccaac tcaacaacat tctataactg ataactccct gagcctcaag acacctcccg    120

 agtgtctgct cactcccctt ccaccctcag cgg atg ata atc tca aga aag aaa     174
                                      Met Ile Ile Ser Arg Lys Lys
                                        1               5

 gag aaa gaa gga agg agg aca gca cag ctg aca gcc gtg ctc agg aag      222
 Glu Lys Glu Gly Arg Arg Thr Ala Gln Leu Thr Ala Val Leu Arg Lys
          10                  15                  20

 att ctg gat cct agg ctc atc tcc aca gag gag aac acg cag gga gca      270
 Ile Leu Asp Pro Arg Leu Ile Ser Thr Glu Glu Asn Thr Gln Gly Ala
      25                  30                  35

 gag acc atg ggg ccc ctc tca gcc cct ccc tgc aca cag cat ata acc      318
 Glu Thr Met Gly Pro Leu Ser Ala Pro Pro Cys Thr Gln His Ile Thr
  40                  45                  50                  55

 tgg aaa ggg ctc ctg ctc aca gca tca ctt tta aac ttc tgg aac ccg      366
 Trp Lys Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro
                  60                  65                  70

 ccc acc aca gcc caa gtc acg att gaa gcc cag cca cca aaa gtt tct      414
 Pro Thr Thr Ala Gln Val Thr Ile Glu Ala Gln Pro Pro Lys Val Ser
              75                  80                  85

 gag ggg aag gat gtt ctt cta ctt gtc cac aat ttg ccc cag aat ctt      462
 Glu Gly Lys Asp Val Leu Leu Leu Val His Asn Leu Pro Gln Asn Leu
          90                  95                 100

 act ggc tac atc tgg tac aaa gga caa atc agg gac ctc tac cat tat      510
 Thr Gly Tyr Ile Trp Tyr Lys Gly Gln Ile Arg Asp Leu Tyr His Tyr
     105                 110                 115

 gtt aca tca tat gta gta gac ggt caa ata att aaa tat ggg cct gca      558
 Val Thr Ser Tyr Val Val Asp Gly Gln Ile Ile Lys Tyr Gly Pro Ala
 120                 125                 130                 135

 tac agt gga cga gaa aca gta tat tcc aat gca tcc ctg ctg atc cag      606
 Tyr Ser Gly Arg Glu Thr Val Tyr Ser Asn Ala Ser Leu Leu Ile Gln
                 140                 145                 150

 aat gtc acc cag gaa gac aca gga tcc tac act tta cac atc ata aag      654
 Asn Val Thr Gln Glu Asp Thr Gly Ser Tyr Thr Leu His Ile Ile Lys
             155                 160                 165

 cga ggt gat ggg act gga gga gta act gga cgt ttc acc ttc acc tta      702
 Arg Gly Asp Gly Thr Gly Gly Val Thr Gly Arg Phe Thr Phe Thr Leu
         170                 175                 180

 tac ctg gag act ccc aaa ccc tcc atc tcc agc agc aat ttc aac ccc      750
 Tyr Leu Glu Thr Pro Lys Pro Ser Ile Ser Ser Ser Asn Phe Asn Pro
     185                 190                 195

 agg gag gcc acg gag gct gtg atc tta acc tgt gat cct gag act cca      798
 Arg Glu Ala Thr Glu Ala Val Ile Leu Thr Cys Asp Pro Glu Thr Pro
 200                 205                 210                 215

 gat gca agc tac ctg tgg tgg atg aat ggt cag agc ctc cct atg act      846
 Asp Ala Ser Tyr Leu Trp Trp Met Asn Gly Gln Ser Leu Pro Met Thr
                 220                 225                 230

 cac agc ttg cag ctg tct gaa acc aac agg acc ctc tac cta ttt ggt      894
 His Ser Leu Gln Leu Ser Glu Thr Asn Arg Thr Leu Tyr Leu Phe Gly
             235                 240                 245

 gtc aca aac tat act gca gga ccc tat gaa tgt gaa ata cgg aac cca      942
 Val Thr Asn Tyr Thr Ala Gly Pro Tyr Glu Cys Glu Ile Arg Asn Pro
         250                 255                 260

 gtg agt gcc agc cgc agt gac cca gtc acc ctg aat ctc ctc ccg aag      990
 Val Ser Ala Ser Arg Ser Asp Pro Val Thr Leu Asn Leu Leu Pro Lys
     265                 270                 275

 ctg ccc aag ccc tac atc acc atc aat aac tta aac ccc agg gag aat     1038
 Leu Pro Lys Pro Tyr Ile Thr Ile Asn Asn Leu Asn Pro Arg Glu Asn
 280                 285                 290                 295

 aag gat gtc tca acc ttc acc tgt gaa cct aag agt gag aac tac acc     1086
 Lys Asp Val Ser Thr Phe Thr Cys Glu Pro Lys Ser Glu Asn Tyr Thr
                 300                 305                 310

 tac att tgg tgg cta aat ggt cag agc ctc ccg gtc agt ccc agg gta     1134
 Tyr Ile Trp Trp Leu Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Val
             315                 320                 325

 aag cga cgc att gaa aac agg atc ctc att cta ccc agt gtc acg aga     1182
 Lys Arg Arg Ile Glu Asn Arg Ile Leu Ile Leu Pro Ser Val Thr Arg
         330                 335                 340

 aat gaa aca gga ccc tat caa tgt gaa ata cgg gac cga tat ggt ggc     1230
 Asn Glu Thr Gly Pro Tyr Gln Cys Glu Ile Arg Asp Arg Tyr Gly Gly
     345                 350                 355

 atc cgc agt gac cca gtc acc ctg aat gtc ctc tat ggt cca gac ctc     1278
 Ile Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Leu
 360                 365                 370                 375

 ccc aga att tac cct tcg ttc acc tat tac cat tca gga caa aac ctc     1326
 Pro Arg Ile Tyr Pro Ser Phe Thr Tyr Tyr His Ser Gly Gln Asn Leu
                 380                 385                 390

 tac ttg tcc tgc ttt gcg gac tct aac cca ccg gca cag tat tct tgg     1374
 Tyr Leu Ser Cys Phe Ala Asp Ser Asn Pro Pro Ala Gln Tyr Ser Trp
             395                 400                 405

 aca att aat ggg aag ttt cag cta tca gga caa aag ctt tct atc ccc     1422
 Thr Ile Asn Gly Lys Phe Gln Leu Ser Gly Gln Lys Leu Ser Ile Pro
         410                 415                 420

 cag att act aca aag cat agc ggg ctc tat gct tgc tct gtt cgt aac     1470
 Gln Ile Thr Thr Lys His Ser Gly Leu Tyr Ala Cys Ser Val Arg Asn
     425                 430                 435

 tca gcc act ggc aag gaa agc tcc aaa tcc gtg aca gtc aga gtc tct     1518
 Ser Ala Thr Gly Lys Glu Ser Ser Lys Ser Val Thr Val Arg Val Ser
 440                 445                 450                 455

 gac tgg aca tta ccc tga attcta ctagttcctc caattccatc ttctcccatg     1572
 Asp Trp Thr Leu Pro 
                 460

 gaacctcaaa gagcaagacc cactctgttc cagaagccct ataagtcaga gttggacaac   1632

 tcaatgtaaa tttcatggga aaatccttgt acctgatgtc tgagccactc agaactcacc   1692

 aaaatgttca acaccataac aacagctgct caaactgtaa acaaggaaaa caagttgatg   1752

 acttcacact gtggacagtt tttcccaaga tgtcagaata agactcccca tcatgatgag   1812

 gctctcaccc ctcttagctg tccttgcttg tgcctgcctc tttcacttgg caggataatg   1872

 cagtcattag aatttcacat gtagtatagg agcttctgag ggtaacaaca gagtgtcaga   1932

 tatgtcatct caacctcaaa cttttacata acatctcagg aggaaatgtg gctctctcca   1992

 tcttgcatac agggctccca atagaaatga acacagagat attgcctgtg tgtttgcaga   2052

 gaagatggtt tctataaaga gtaggaaagc tgaaattata gtagagtccc ctttaaatgc   2112

 acattgtgtg gatggctctc accatttcct aagagataca ttgtaaaacg tgacagtaag   2172

 actgattcta gcagaataaa acatgtacta catttgctaa a                       2213




      <210> 548
      <211> 1406
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (154)..(1275)

      <400> 548
 tgccctactg gccctacctc acagctgaaa ctttaaaaaa caggatgggc caccagccac     60

 ctcctccaac tcaacaacat tctataactg ataactccct gagcctcaag acacctcccg    120

 agtgtctgct cactcccctt ccaccctcag cgg atg ata atc tca aga aag aaa     174
                                      Met Ile Ile Ser Arg Lys Lys
                                        1               5

 gag aaa gaa gga agg agg aca gca cag ctg aca gcc gtg ctc tgg aag      222
 Glu Lys Glu Gly Arg Arg Thr Ala Gln Leu Thr Ala Val Leu Trp Lys
          10                  15                  20

 ctt ctg gat cct agg ctc atc tcc aca gag gag aac atg cac gca gca      270
 Leu Leu Asp Pro Arg Leu Ile Ser Thr Glu Glu Asn Met His Ala Ala
      25                  30                  35

 gag atc atg ggg ccc ctc tca gcc cct ccc tgc aca gag cac atc aaa      318
 Glu Ile Met Gly Pro Leu Ser Ala Pro Pro Cys Thr Glu His Ile Lys
  40                  45                  50                  55

 tgg aag ggg ctc ctg ctc aca gca tta ctt tta aac ttc tgg aac ctg      366
 Trp Lys Gly Leu Leu Leu Thr Ala Leu Leu Leu Asn Phe Trp Asn Leu
                  60                  65                  70

 cct acc act gcc caa gtc atg att gaa gcc cag cca ccc aaa gtg tcc      414
 Pro Thr Thr Ala Gln Val Met Ile Glu Ala Gln Pro Pro Lys Val Ser
              75                  80                  85

 gag ggg aag gat gtt ctt cta ctt gtc cac aat ttg ccc cag aat ctt      462
 Glu Gly Lys Asp Val Leu Leu Leu Val His Asn Leu Pro Gln Asn Leu
          90                  95                 100

 act ggc tac atc tgg tac aaa ggg caa atc agg gac ctc tac cat tac      510
 Thr Gly Tyr Ile Trp Tyr Lys Gly Gln Ile Arg Asp Leu Tyr His Tyr
     105                 110                 115

 att aca tca tat gta gta gac ggt caa ata att ata tat gga ccg gca      558
 Ile Thr Ser Tyr Val Val Asp Gly Gln Ile Ile Ile Tyr Gly Pro Ala
 120                 125                 130                 135

 tac agt gga cga gaa aca gta tat tcc aat gca tcc ctg ctg atc cag      606
 Tyr Ser Gly Arg Glu Thr Val Tyr Ser Asn Ala Ser Leu Leu Ile Gln
                 140                 145                 150

 aat gtc acc cgg gag gac gca gga tcc tac acc tta cac atc ata aag      654
 Asn Val Thr Arg Glu Asp Ala Gly Ser Tyr Thr Leu His Ile Ile Lys
             155                 160                 165

 cga ggt gat ggg act aga gga gta act gga tat ttc acc ttc acc tta      702
 Arg Gly Asp Gly Thr Arg Gly Val Thr Gly Tyr Phe Thr Phe Thr Leu
         170                 175                 180

 tac ctg gag act ccc aag ccc tcc atc tcc agc agc aac tta aac ccc      750
 Tyr Leu Glu Thr Pro Lys Pro Ser Ile Ser Ser Ser Asn Leu Asn Pro
     185                 190                 195

 agg gag gcc atg gag act gtg atc tta acc tgt aat cct gag act ccg      798
 Arg Glu Ala Met Glu Thr Val Ile Leu Thr Cys Asn Pro Glu Thr Pro
 200                 205                 210                 215

 gac gca agc tac ctg tgg tgg atg aat ggt cag agc ctc cct atg act      846
 Asp Ala Ser Tyr Leu Trp Trp Met Asn Gly Gln Ser Leu Pro Met Thr
                 220                 225                 230

 cat agg atg cag ctg tct gaa acc aac agg acc ctc ttt cta ttt ggt      894
 His Arg Met Gln Leu Ser Glu Thr Asn Arg Thr Leu Phe Leu Phe Gly
             235                 240                 245

 gtc aca aag tat act gca gga ccc tat gaa tgt gaa ata tgg aac tca      942
 Val Thr Lys Tyr Thr Ala Gly Pro Tyr Glu Cys Glu Ile Trp Asn Ser
         250                 255                 260

 ggg agt gcc agc cgc agt gac cca gtc acc ctg aat ctc ctc cat ggt      990
 Gly Ser Ala Ser Arg Ser Asp Pro Val Thr Leu Asn Leu Leu His Gly
     265                 270                 275

 cca gac ctc ccc aga att ttc cct tca gtc acc tct tac tat tca gga     1038
 Pro Asp Leu Pro Arg Ile Phe Pro Ser Val Thr Ser Tyr Tyr Ser Gly
 280                 285                 290                 295

 gag aac ctc gac ttg tcc tgc ttc gca gac tct aac cca cca gca cag     1086
 Glu Asn Leu Asp Leu Ser Cys Phe Ala Asp Ser Asn Pro Pro Ala Gln
                 300                 305                 310

 tat tct tgg aca att aat ggg aag ttt cag cta tca gga caa aag ctc     1134
 Tyr Ser Trp Thr Ile Asn Gly Lys Phe Gln Leu Ser Gly Gln Lys Leu
             315                 320                 325

 ttt atc cct cag att act cca aag cat aat ggg ctc tat gct tgc tct     1182
 Phe Ile Pro Gln Ile Thr Pro Lys His Asn Gly Leu Tyr Ala Cys Ser
         330                 335                 340

 gct cgt aac tca gcc act ggc gag gaa agc tcc aca tcc ttg aca atc     1230
 Ala Arg Asn Ser Ala Thr Gly Glu Glu Ser Ser Thr Ser Leu Thr Ile
     345                 350                 355

 aga gtc att gct cct cca gga tta gga act ttt tgc ttt caa taa tcc     1278
 Arg Val Ile Ala Pro Pro Gly Leu Gly Thr Phe Cys Phe Gln 
 360                 365                 370

 aagtagcagc cctgatgtca tttttgtatt tcaggaagac tggcaggaga tttatggaaa   1338

 agactatgaa aaggactctt gaatacaagt tcctgataac ttcaagatca taccactgga   1398

 ctaagaac                                                            1406




      <210> 549
      <211> 510
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(510)

      <400> 549
  atg ctc ctg tcc ctt ttc tgc ttt gat ggc aca gct gga gac agc aag      48
  Met Leu Leu Ser Leu Phe Cys Phe Asp Gly Thr Ala Gly Asp Ser Lys
    1               5                  10                  15

 gcc ctg aaa gaa gcc agt aag gag agt gac cac gtg gtc act gtc att       96
 Ala Leu Lys Glu Ala Ser Lys Glu Ser Asp His Val Val Thr Val Ile
              20                  25                  30

 gac gca cac act gca gaa gcc atc aca tgt gaa aag gca ctt tcc agc      144
 Asp Ala His Thr Ala Glu Ala Ile Thr Cys Glu Lys Ala Leu Ser Ser
          35                  40                  45

 ctg agc gct ggt aca gcc gca ccc ggc tcc atc tcc gac cgg gac aga      192
 Leu Ser Ala Gly Thr Ala Ala Pro Gly Ser Ile Ser Asp Arg Asp Arg
      50                  55                  60

 gcc atg gcc acc agc agg tcc tcg gac ggt gcc tcg tcc acc ttc cgc      240
 Ala Met Ala Thr Ser Arg Ser Ser Asp Gly Ala Ser Ser Thr Phe Arg
  65                  70                  75                  80

 ctc ttc cgt ggc tcc ttc ttg ctg gct atc atc atg tgc cga tgc tcc      288
 Leu Phe Arg Gly Ser Phe Leu Leu Ala Ile Ile Met Cys Arg Cys Ser
                  85                  90                  95

 tac ccg tgc aaa ctc ctg ctg cag ggt caa ggc cac cgc agc gtc gct      336
 Tyr Pro Cys Lys Leu Leu Leu Gln Gly Gln Gly His Arg Ser Val Ala
             100                 105                 110

 ctc tgg ggc agg ggg ccc aag ccc ata cac tgt gga gaa gca cca aag      384
 Leu Trp Gly Arg Gly Pro Lys Pro Ile His Cys Gly Glu Ala Pro Lys
         115                 120                 125

 atc cgt gag aat aaa ctc caa aga caa gct cac cct cag acc tct gct      432
 Ile Arg Glu Asn Lys Leu Gln Arg Gln Ala His Pro Gln Thr Ser Ala
     130                 135                 140

 ctg tca gct cct gca gac cat ggg gag cag gtg gaa cgc aaa gaa acc      480
 Leu Ser Ala Pro Ala Asp His Gly Glu Gln Val Glu Arg Lys Glu Thr
 145                 150                 155                 160

 aga acc cag ctc cac tct gca ggc tgg tga                              510
 Arg Thr Gln Leu His Ser Ala Gly Trp 
                 165





      <210> 550
      <211> 925
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (620)..(925)

      <400> 550
 tgattagatg tgtagaagaa aatcagctgt atagcataga aatagaaaag acccaaagta     60

 aaacacaagg aggaaaaaag agcttcagtg acctgtggaa cagtatcagg cagtgtgaca    120

 taacctagaa gtcccagaag aggaggagaa gaaggtgtga agaaaaaaaa tatttgaaga    180

 aacaatggca ggcaatgcca gaaaatactt caaatgtggt aagagcaata aacccacaat    240

 ttgaagatgc ttaataaaac tcaagaaaga taaagaaaac catattgagg ccccaaagtg    300

 taggaggaga accttaagca cagaggcaga aatataagaa tgaataggca tggatttctc    360

 atcagcaatt agccaaaaaa gaaaaaaaac agtggaccca caactttaaa gtgctagaag    420

 aaagactgtc aacctataat tctatttcca gagtaaatat tatttaaaat taaggagaaa    480

 taaagacctt tccagaaaaa caaaagctga atttgtcacc agcaaattta ggtaataaga    540

 gaagttagag aaagttctta aggaggaatt aaaatgatat aggtgagcat ctatccatca    600

 agaaaaagaa aaatccact atg ata gat atg gat aat aca gtg atg ttg tca     652
                      Met Ile Asp Met Asp Asn Thr Val Met Leu Ser
                        1               5                  10

 ggg ctg gag aaa tgg aat gcc aaa aga gaa aga act aat aaa caa gag      700
 Gly Leu Glu Lys Trp Asn Ala Lys Arg Glu Arg Thr Asn Lys Gln Glu
              15                  20                  25

 gaa caa aga aca gat gaa ata aac aac aaa caa gta tta aaa act cta      748
 Glu Gln Arg Thr Asp Glu Ile Asn Asn Lys Gln Val Leu Lys Thr Leu
          30                  35                  40

 agc tca gaa ggc tac act ggt tca ttc tac cag atg ttt tta aaa gaa      796
 Ser Ser Glu Gly Tyr Thr Gly Ser Phe Tyr Gln Met Phe Leu Lys Glu
      45                  50                  55

 tta ata ctg att cta ccc aga ctc ttc cag aaa aca gaa gag agg aaa      844
 Leu Ile Leu Ile Leu Pro Arg Leu Phe Gln Lys Thr Glu Glu Arg Lys
  60                  65                  70                  75

 aca cct ctg aac tca tct tat gag gcc aag aat atc cgg ata cca aaa      892
 Thr Pro Leu Asn Ser Ser Tyr Glu Ala Lys Asn Ile Arg Ile Pro Lys
                  80                  85                  90

 cca gat gaa gat att aca aga aaa acc tac tga                          925
 Pro Asp Glu Asp Ile Thr Arg Lys Thr Tyr 
              95                 100





      <210> 551
      <211> 729
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(729)

      <400> 551
  atg tca gac aag ctc aag gaa cgc aaa aga acc ccc gtt tct cat aaa      48
  Met Ser Asp Lys Leu Lys Glu Arg Lys Arg Thr Pro Val Ser His Lys
    1               5                  10                  15

 gtg ata gaa aag cgg agg agg gac agg atc aac cgc tgc ttg aac gag       96
 Val Ile Glu Lys Arg Arg Arg Asp Arg Ile Asn Arg Cys Leu Asn Glu
              20                  25                  30

 ctg ggc aag aca gtg ccc atg gcc ttg gcg aag cag agt tcc ggg aag      144
 Leu Gly Lys Thr Val Pro Met Ala Leu Ala Lys Gln Ser Ser Gly Lys
          35                  40                  45

 ctg gag aag gcg gag atc ctc gag atg acc gtt cag tac ctg aga gca      192
 Leu Glu Lys Ala Glu Ile Leu Glu Met Thr Val Gln Tyr Leu Arg Ala
      50                  55                  60

 ctg cac tcc gct gat ttt ccc cgg gga agg gaa aaa gca gaa ctt cta      240
 Leu His Ser Ala Asp Phe Pro Arg Gly Arg Glu Lys Ala Glu Leu Leu
  65                  70                  75                  80

 gcg gag ttt gcc aac tac ttc cac tat ggc tac cac gag tgc atg aag      288
 Ala Glu Phe Ala Asn Tyr Phe His Tyr Gly Tyr His Glu Cys Met Lys
                  85                  90                  95

 aac ctg gtg cat tac ctc acc acg gtg gag cgg atg gag acc aag gac      336
 Asn Leu Val His Tyr Leu Thr Thr Val Glu Arg Met Glu Thr Lys Asp
             100                 105                 110

 acg aag tac gcg cgc atc ctc gcc ttc ttg cag tcc aag gcc cgc ctg      384
 Thr Lys Tyr Ala Arg Ile Leu Ala Phe Leu Gln Ser Lys Ala Arg Leu
         115                 120                 125

 ggc gcg gag ccc gcc ttt ccg ccg ctg ggt tcg ctc ccg gag ccg gat      432
 Gly Ala Glu Pro Ala Phe Pro Pro Leu Gly Ser Leu Pro Glu Pro Asp
     130                 135                 140

 ttc tcc tat cag ctg cac cct gcg ggg ccc gaa ttc gct ggt cac agc      480
 Phe Ser Tyr Gln Leu His Pro Ala Gly Pro Glu Phe Ala Gly His Ser
 145                 150                 155                 160

 ccg ggc gag gcc gct gtg ttc ccg cag ggc tct ggt gcc ggg cct ttc      528
 Pro Gly Glu Ala Ala Val Phe Pro Gln Gly Ser Gly Ala Gly Pro Phe
                 165                 170                 175

 ccc tgg ccg cct ggc gcg gcc cgc agc ccc gcg ctg ccc tac ctg ccc      576
 Pro Trp Pro Pro Gly Ala Ala Arg Ser Pro Ala Leu Pro Tyr Leu Pro
             180                 185                 190

 agc gcg cca gtg ccg ctc gct agc cca gcg cag cag cac agc ccc ttc      624
 Ser Ala Pro Val Pro Leu Ala Ser Pro Ala Gln Gln His Ser Pro Phe
         195                 200                 205

 ctg aca ccg gtg cag ggc ctg gac cgg cat tac ctc aac ctg atc ggc      672
 Leu Thr Pro Val Gln Gly Leu Asp Arg His Tyr Leu Asn Leu Ile Gly
     210                 215                 220

 cac gcg cac ccc aac gcc ctt aac ctg cac acg ccc cag cac ccc ccg      720
 His Ala His Pro Asn Ala Leu Asn Leu His Thr Pro Gln His Pro Pro
 225                 230                 235                 240

 gtg ctc tga                                                          729
 Val Leu 






      <210> 552
      <211> 840
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(840)

      <400> 552
  atg tca gac aag ctc aag gaa cgc aaa aga acc ccc gtt tct cat aaa      48
  Met Ser Asp Lys Leu Lys Glu Arg Lys Arg Thr Pro Val Ser His Lys
    1               5                  10                  15

 gtg ata gaa aag cgg agg agg gac agg atc aac cgc tgc ttg aac gag       96
 Val Ile Glu Lys Arg Arg Arg Asp Arg Ile Asn Arg Cys Leu Asn Glu
              20                  25                  30

 ctg ggc aag aca gtg ccc atg gcc ttg gcg aag cag gag gct ctg gcg      144
 Leu Gly Lys Thr Val Pro Met Ala Leu Ala Lys Gln Glu Ala Leu Ala
          35                  40                  45

 cag atc cgc agc cgc gtc cgc tcg ctg gtc ctc tcc agc gcc aca gtg      192
 Gln Ile Arg Ser Arg Val Arg Ser Leu Val Leu Ser Ser Ala Thr Val
      50                  55                  60

 ccc gac cag cag gcg ctg ggc cgc tgc gag ggg ccc ttc ctc ctt ttg      240
 Pro Asp Gln Gln Ala Leu Gly Arg Cys Glu Gly Pro Phe Leu Leu Leu
  65                  70                  75                  80

 cag agt tcc ggg aag ctg gag aag gcg gag atc ctc gag atg acc gtt      288
 Gln Ser Ser Gly Lys Leu Glu Lys Ala Glu Ile Leu Glu Met Thr Val
                  85                  90                  95

 cag tac ctg aga gca ctg cac tcc gct gat ttt ccc cgg gga agg gaa      336
 Gln Tyr Leu Arg Ala Leu His Ser Ala Asp Phe Pro Arg Gly Arg Glu
             100                 105                 110

 aaa gca gaa ctt cta gcg gag ttt gcc aac tac ttc cac tat ggc tac      384
 Lys Ala Glu Leu Leu Ala Glu Phe Ala Asn Tyr Phe His Tyr Gly Tyr
         115                 120                 125

 cac gag tgc atg aag aac ctg gtg cat tac ctc acc acg gtg gag cgg      432
 His Glu Cys Met Lys Asn Leu Val His Tyr Leu Thr Thr Val Glu Arg
     130                 135                 140

 atg gag acc aag gac acg aag tac gcg cgc atc ctc gcc ttc ttg cag      480
 Met Glu Thr Lys Asp Thr Lys Tyr Ala Arg Ile Leu Ala Phe Leu Gln
 145                 150                 155                 160

 tcc aag gcc cgc ctg ggc gcg gag ccc gcc ttt ccg ccg ctg ggt tcg      528
 Ser Lys Ala Arg Leu Gly Ala Glu Pro Ala Phe Pro Pro Leu Gly Ser
                 165                 170                 175

 ctc ccg gag ccg gat ttc tcc tat cag ctg cac cct gcg ggg ccc gaa      576
 Leu Pro Glu Pro Asp Phe Ser Tyr Gln Leu His Pro Ala Gly Pro Glu
             180                 185                 190

 ttc gct ggt cac agc ccg ggc gag gcc gct gtg ttc ccg cag ggc tct      624
 Phe Ala Gly His Ser Pro Gly Glu Ala Ala Val Phe Pro Gln Gly Ser
         195                 200                 205

 ggt gcc ggg cct ttc ccc tgg ccg cct ggc gcg gcc cgc agc ccc gcg      672
 Gly Ala Gly Pro Phe Pro Trp Pro Pro Gly Ala Ala Arg Ser Pro Ala
     210                 215                 220

 ctg ccc tac ctg ccc agc gcg cca gtg ccg ctc gct agc cca gcg cag      720
 Leu Pro Tyr Leu Pro Ser Ala Pro Val Pro Leu Ala Ser Pro Ala Gln
 225                 230                 235                 240

 cag cac agc ccc ttc ctg aca ccg gtg cag ggc ctg gac cgg cat tac      768
 Gln His Ser Pro Phe Leu Thr Pro Val Gln Gly Leu Asp Arg His Tyr
                 245                 250                 255

 ctc aac ctg atc ggc cac gcg cac ccc aac gcc ctt aac ctg cac acg      816
 Leu Asn Leu Ile Gly His Ala His Pro Asn Ala Leu Asn Leu His Thr
             260                 265                 270

 ccc cag cac ccc ccg gtg ctc tga                                      840
 Pro Gln His Pro Pro Val Leu 
         275





      <210> 553
      <211> 456
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(456)

      <400> 553
  atg gcg cac agt tgg aaa ttg gtg gca ttg agt cgc tgc caa ggc tgg      48
  Met Ala His Ser Trp Lys Leu Val Ala Leu Ser Arg Cys Gln Gly Trp
    1               5                  10                  15

 cag acc ttt aag atg gca tct gca gct gtc cca aac cat ctg ccc tta       96
 Gln Thr Phe Lys Met Ala Ser Ala Ala Val Pro Asn His Leu Pro Leu
              20                  25                  30

 att cag act ttc tac ccc atc att tcc ccg atg aga ccc aag gct gaa      144
 Ile Gln Thr Phe Tyr Pro Ile Ile Ser Pro Met Arg Pro Lys Ala Glu
          35                  40                  45

 aat acc tgt tac att tac aac aag gag aat gac agc ttg aaa aca gaa      192
 Asn Thr Cys Tyr Ile Tyr Asn Lys Glu Asn Asp Ser Leu Lys Thr Glu
      50                  55                  60

 acc caa aca atg cac cag aaa cca atg act gat aat gca agg cag atg      240
 Thr Gln Thr Met His Gln Lys Pro Met Thr Asp Asn Ala Arg Gln Met
  65                  70                  75                  80

 agc aga gac acc cca gtt ccc att aac ttc act gat cag caa acc act      288
 Ser Arg Asp Thr Pro Val Pro Ile Asn Phe Thr Asp Gln Gln Thr Thr
                  85                  90                  95

 gat aat cca gat gat gtg aaa gag aaa aag cac cca gag aac aac cag      336
 Asp Asn Pro Asp Asp Val Lys Glu Lys Lys His Pro Glu Asn Asn Gln
             100                 105                 110

 aaa tca gaa aac aac cag aaa cta cta aca ggg gca aac agt agc aga      384
 Lys Ser Glu Asn Asn Gln Lys Leu Leu Thr Gly Ala Asn Ser Ser Arg
         115                 120                 125

 ttc ctg gat ggc aat gta gca tgt tca tta ggt aag ctg ttc tta acc      432
 Phe Leu Asp Gly Asn Val Ala Cys Ser Leu Gly Lys Leu Phe Leu Thr
     130                 135                 140

 tcc atg atc tgg att att tgc tag                                      456
 Ser Met Ile Trp Ile Ile Cys 
 145                 150





      <210> 554
      <211> 925
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (287)..(925)

      <400> 554
 gttatctgcc cacagatctg ctcacagaag gtgcctcacc aggtcacagt tggcagtcga     60

 gcagtcagtc attcctgcaa atggggagtt ttgtcagaat cttctggact tggagttacc    120

 tgttcattcc ttgaggagag gagggactga ggatcaaaga gcaaaccttt tggcctgggg    180

 tcttgctgga ttgagggtgt gcaaatattg gttgagcacc tacaatgtgt caggcattgt    240

 gggagccact agggattcag cagaatcaga tgagatttct gctgtc   atg gaa gat     295
                                                      Met Glu Asp
                                                        1

 ctg ttc tcc tgc ttc ttc aac ttc acc agc ccg tct ggg gtt gtc ctg      343
 Leu Phe Ser Cys Phe Phe Asn Phe Thr Ser Pro Ser Gly Val Val Leu
       5                  10                  15

 tct ccc aac tac cca gag gac tat ggc aac cac ctc cac tgt gtc tgg      391
 Ser Pro Asn Tyr Pro Glu Asp Tyr Gly Asn His Leu His Cys Val Trp
  20                  25                  30                  35

 ctc atc ctg gcc agg cct gag agc cgc atc cac ctg gcc ttc aac gac      439
 Leu Ile Leu Ala Arg Pro Glu Ser Arg Ile His Leu Ala Phe Asn Asp
                  40                  45                  50

 att gac gtg gag cct cag ttt gat ttc ctg gtc atc aag gat ggg gcc      487
 Ile Asp Val Glu Pro Gln Phe Asp Phe Leu Val Ile Lys Asp Gly Ala
              55                  60                  65

 acc gcc gag gcg ccc gtc ctg ggc acc ttc tca gga aac cag ctt ccc      535
 Thr Ala Glu Ala Pro Val Leu Gly Thr Phe Ser Gly Asn Gln Leu Pro
          70                  75                  80

 tcc tcc atc aca agc agt ggc cac gtg gcc cgt ctc gag ttc cag act      583
 Ser Ser Ile Thr Ser Ser Gly His Val Ala Arg Leu Glu Phe Gln Thr
      85                  90                  95

 gac cac tcc aca ggg aag agg ggc ttc aac atc act ttt acc act ggc      631
 Asp His Ser Thr Gly Lys Arg Gly Phe Asn Ile Thr Phe Thr Thr Gly
 100                 105                 110                 115

 cct cca tct gag tgt ctg cct ctg agg atg atc gaa ggt gct ccc atg      679
 Pro Pro Ser Glu Cys Leu Pro Leu Arg Met Ile Glu Gly Ala Pro Met
                 120                 125                 130

 gag gga gga gga gcc ttc cga cac aac gag tgc ccg gat cct ggc gtt      727
 Glu Gly Gly Gly Ala Phe Arg His Asn Glu Cys Pro Asp Pro Gly Val
             135                 140                 145

 cca gta aat ggc aaa cgg ttt ggg gac agc ctc cag ctg ggc agc tcc      775
 Pro Val Asn Gly Lys Arg Phe Gly Asp Ser Leu Gln Leu Gly Ser Ser
         150                 155                 160

 atc tcc ttc ctc tgt gat gaa ggc ttc ctt ggg act cag ggc tca gag      823
 Ile Ser Phe Leu Cys Asp Glu Gly Phe Leu Gly Thr Gln Gly Ser Glu
     165                 170                 175

 acc atc acc tgc gtc ctg aag gag ggc agc gtg gtc tgg aac agc gct      871
 Thr Ile Thr Cys Val Leu Lys Glu Gly Ser Val Val Trp Asn Ser Ala
 180                 185                 190                 195

 gtg ctg cgg tgt gaa gca gcc tta gac aat acg gaa gtg aat ggg cta      919
 Val Leu Arg Cys Glu Ala Ala Leu Asp Asn Thr Glu Val Asn Gly Leu
                 200                 205                 210

 gat tga                                                              925
 Asp 






      <210> 555
      <211> 2397
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2397)

      <400> 555
  atg cag acc cag gag ccc cct cag ttg cag tcg aca ccc cgg ccg ctg      48
  Met Gln Thr Gln Glu Pro Pro Gln Leu Gln Ser Thr Pro Arg Pro Leu
    1               5                  10                  15

 cag gag gaa gtc cca gtg gtt aga cct ctg cag cca aga gca gca aga       96
 Gln Glu Glu Val Pro Val Val Arg Pro Leu Gln Pro Arg Ala Ala Arg
              20                  25                  30

 gga gga gca gga gga gga gca cag tct caa ggg gtg aag gaa cct gga      144
 Gly Gly Ala Gly Gly Gly Ala Gln Ser Gln Gly Val Lys Glu Pro Gly
          35                  40                  45

 cct gag gct ggg ttg cat aca gcg ccc ttg cag gag aga agg att ggt      192
 Pro Glu Ala Gly Leu His Thr Ala Pro Leu Gln Glu Arg Arg Ile Gly
      50                  55                  60

 gga gtt ttt caa gac ctg gtg gtg aac acc agg caa gat atg aag cat      240
 Gly Val Phe Gln Asp Leu Val Val Asn Thr Arg Gln Asp Met Lys His
  65                  70                  75                  80

 gtt aaa gac tca aaa aca ggt tca gag ggt aca gtg gta cag cta ctc      288
 Val Lys Asp Ser Lys Thr Gly Ser Glu Gly Thr Val Val Gln Leu Leu
                  85                  90                  95

 gcc aac cac ttc cga gtg ata tct cgt cct cag tgg gtt gca tat aaa      336
 Ala Asn His Phe Arg Val Ile Ser Arg Pro Gln Trp Val Ala Tyr Lys
             100                 105                 110

 tac aac gtt gac tac aaa cca gac ata gaa gat gga aat ctc cgt aca      384
 Tyr Asn Val Asp Tyr Lys Pro Asp Ile Glu Asp Gly Asn Leu Arg Thr
         115                 120                 125

 att tta ctt gat caa cat aga agg aaa ttt gga gag cgc cat ata ttt      432
 Ile Leu Leu Asp Gln His Arg Arg Lys Phe Gly Glu Arg His Ile Phe
     130                 135                 140

 gat gga aac tct tta tta tta tct cgg cca cta aaa gag cgg aga gtg      480
 Asp Gly Asn Ser Leu Leu Leu Ser Arg Pro Leu Lys Glu Arg Arg Val
 145                 150                 155                 160

 gaa tgg ttg agc aca acc aaa gac aaa aac atc gtg aag att aca gtt      528
 Glu Trp Leu Ser Thr Thr Lys Asp Lys Asn Ile Val Lys Ile Thr Val
                 165                 170                 175

 gag ttt tcc aaa gaa ctc acg ccc acg tcg cca gat tgc cta cgc tat      576
 Glu Phe Ser Lys Glu Leu Thr Pro Thr Ser Pro Asp Cys Leu Arg Tyr
             180                 185                 190

 tac aac att ctc ttt aga aga act ttc aag ctg ctg gat ttt gaa caa      624
 Tyr Asn Ile Leu Phe Arg Arg Thr Phe Lys Leu Leu Asp Phe Glu Gln
         195                 200                 205

 gtt ggt cgc aac tat tat acc aaa aag aag gcc att cag tta tac cgt      672
 Val Gly Arg Asn Tyr Tyr Thr Lys Lys Lys Ala Ile Gln Leu Tyr Arg
     210                 215                 220

 cat ggt acc agt ttg gaa atc tgg ctt ggt tat gtt act tct gtt ctt      720
 His Gly Thr Ser Leu Glu Ile Trp Leu Gly Tyr Val Thr Ser Val Leu
 225                 230                 235                 240

 caa tac gaa aac agc att acc ctc tgt gcc gat gtg agc cac aaa ctg      768
 Gln Tyr Glu Asn Ser Ile Thr Leu Cys Ala Asp Val Ser His Lys Leu
                 245                 250                 255

 ctc cga ata gaa act gct tat gat ttc ata aag aga aca tct gcc cag      816
 Leu Arg Ile Glu Thr Ala Tyr Asp Phe Ile Lys Arg Thr Ser Ala Gln
             260                 265                 270

 gcc cag aca gga aac atc cga gag gaa gta act aat aaa tta att gga      864
 Ala Gln Thr Gly Asn Ile Arg Glu Glu Val Thr Asn Lys Leu Ile Gly
         275                 280                 285

 tca att gtt ctg aca aaa tac aac aac aaa acc tac aga gta gat gat      912
 Ser Ile Val Leu Thr Lys Tyr Asn Asn Lys Thr Tyr Arg Val Asp Asp
     290                 295                 300

 att gat tgg aag cag aat cct gaa gac aca ttt aac aaa tca gat ggc      960
 Ile Asp Trp Lys Gln Asn Pro Glu Asp Thr Phe Asn Lys Ser Asp Gly
 305                 310                 315                 320

 agc aaa atc acc tat ata gac tac tac agg cag caa cat aaa gaa att     1008
 Ser Lys Ile Thr Tyr Ile Asp Tyr Tyr Arg Gln Gln His Lys Glu Ile
                 325                 330                 335

 gtc aca gtg aag aaa cag cca ctt ttg gtc agc cag ggc aga tgg aaa     1056
 Val Thr Val Lys Lys Gln Pro Leu Leu Val Ser Gln Gly Arg Trp Lys
             340                 345                 350

 aag ggc cta acg ggt aca caa cgt gaa cct atc ctg ctg att cct cag     1104
 Lys Gly Leu Thr Gly Thr Gln Arg Glu Pro Ile Leu Leu Ile Pro Gln
         355                 360                 365

 ctg tgc cac atg aca ggt act gat gga tta cag ccc ctc ttt aaa gtc     1152
 Leu Cys His Met Thr Gly Thr Asp Gly Leu Gln Pro Leu Phe Lys Val
     370                 375                 380

 agg tat aat tac gac tta acg cag gct ttt cag gga att cga agg gtt     1200
 Arg Tyr Asn Tyr Asp Leu Thr Gln Ala Phe Gln Gly Ile Arg Arg Val
 385                 390                 395                 400

 aaa gcc aat tca caa gga gac tgg tca aga gaa ata aga gaa tta ccc     1248
 Lys Ala Asn Ser Gln Gly Asp Trp Ser Arg Glu Ile Arg Glu Leu Pro
                 405                 410                 415

 tta ctt aat gca atg cca cta cat agt tgg ctc ata ctc tat agc agg     1296
 Leu Leu Asn Ala Met Pro Leu His Ser Trp Leu Ile Leu Tyr Ser Arg
             420                 425                 430

 agc agt cac aga gaa gcc atg tcc tta aag ggt cat cta cag agt gtc     1344
 Ser Ser His Arg Glu Ala Met Ser Leu Lys Gly His Leu Gln Ser Val
         435                 440                 445

 aca gcc ccc atg ggc ata act atg aaa cca gca gaa atg att gaa gta     1392
 Thr Ala Pro Met Gly Ile Thr Met Lys Pro Ala Glu Met Ile Glu Val
     450                 455                 460

 gat ggt gat gct aac tcc tat ata gac aca tta cgg aaa tat act aga     1440
 Asp Gly Asp Ala Asn Ser Tyr Ile Asp Thr Leu Arg Lys Tyr Thr Arg
 465                 470                 475                 480

 cca aca ctg cag atg gga atg tca tgt ttg ctg gtt ttc aag gtg att     1488
 Pro Thr Leu Gln Met Gly Met Ser Cys Leu Leu Val Phe Lys Val Ile
                 485                 490                 495

 tgt atc ctg ccc aat gat gac aaa cgt aga tat gac agc ata aaa aga     1536
 Cys Ile Leu Pro Asn Asp Asp Lys Arg Arg Tyr Asp Ser Ile Lys Arg
             500                 505                 510

 tac cta tgt acc aaa tgc cca att cca agc cag tgt gtg gtg aaa aag     1584
 Tyr Leu Cys Thr Lys Cys Pro Ile Pro Ser Gln Cys Val Val Lys Lys
         515                 520                 525

 acc tta gaa aaa gtc cag gca agg acc atc gtc acc aag att gcc cag     1632
 Thr Leu Glu Lys Val Gln Ala Arg Thr Ile Val Thr Lys Ile Ala Gln
     530                 535                 540

 cag atg aat tgc aag atg gga gga gcc ctc tgg aag gtg gag aca aac     1680
 Gln Met Asn Cys Lys Met Gly Gly Ala Leu Trp Lys Val Glu Thr Asn
 545                 550                 555                 560

 gta caa aga aca atg ttc gtt ggc att gat tgt ttc cac gat atc gta     1728
 Val Gln Arg Thr Met Phe Val Gly Ile Asp Cys Phe His Asp Ile Val
                 565                 570                 575

 aat cga cag aaa tca ata gca gga ttt gtt gca agt acc aat gct gaa     1776
 Asn Arg Gln Lys Ser Ile Ala Gly Phe Val Ala Ser Thr Asn Ala Glu
             580                 585                 590

 tta aca aag tgg tac tct caa tgt gtc atc cag aaa aca gga gaa gag     1824
 Leu Thr Lys Trp Tyr Ser Gln Cys Val Ile Gln Lys Thr Gly Glu Glu
         595                 600                 605

 ctt gtg aaa gag ctg gag atc tgc ttg aaa gct gcc ctg gat gtc tgg     1872
 Leu Val Lys Glu Leu Glu Ile Cys Leu Lys Ala Ala Leu Asp Val Trp
     610                 615                 620

 tgt aaa aac gaa tca tcg atg cca cat tct gtt att gtg tat cgg gat     1920
 Cys Lys Asn Glu Ser Ser Met Pro His Ser Val Ile Val Tyr Arg Asp
 625                 630                 635                 640

 gga gtg gga gat ggt cag ctt caa gca ttg ctt gac cat gaa gcg aaa     1968
 Gly Val Gly Asp Gly Gln Leu Gln Ala Leu Leu Asp His Glu Ala Lys
                 645                 650                 655

 aag atg tcg acc tac tta aaa acc atc tct cct aac aat ttc act cta     2016
 Lys Met Ser Thr Tyr Leu Lys Thr Ile Ser Pro Asn Asn Phe Thr Leu
             660                 665                 670

 gct ttc att gtg gtg aag aaa cga ata aac act aga ttt ttt ctt aaa     2064
 Ala Phe Ile Val Val Lys Lys Arg Ile Asn Thr Arg Phe Phe Leu Lys
         675                 680                 685

 cat gga agc aat ttt caa aat cca cct cca gga aca gtt att gat gta     2112
 His Gly Ser Asn Phe Gln Asn Pro Pro Pro Gly Thr Val Ile Asp Val
     690                 695                 700

 gag ttg act agg aat gaa tgg tat gac ttt ttt att gtg agt cag tct     2160
 Glu Leu Thr Arg Asn Glu Trp Tyr Asp Phe Phe Ile Val Ser Gln Ser
 705                 710                 715                 720

 gtg caa gat ggg act gtt acc ccc act cat tat aac gtc atc tat gac     2208
 Val Gln Asp Gly Thr Val Thr Pro Thr His Tyr Asn Val Ile Tyr Asp
                 725                 730                 735

 acg att ggc ttg agc cca gat aca gta cag cgt tta aca tat tgt cta     2256
 Thr Ile Gly Leu Ser Pro Asp Thr Val Gln Arg Leu Thr Tyr Cys Leu
             740                 745                 750

 tgc cac atg tat tat aat ttg cca ggc atc atc cga gtt cca gcg cct     2304
 Cys His Met Tyr Tyr Asn Leu Pro Gly Ile Ile Arg Val Pro Ala Pro
         755                 760                 765

 tgc cac tat gcc cac aag ctg gct tac ctc gtg ggg cag tcc att cac     2352
 Cys His Tyr Ala His Lys Leu Ala Tyr Leu Val Gly Gln Ser Ile His
     770                 775                 780

 cag gaa ccg aat cgt tcc ttg tca act cgt ctc ttt tac ctt tga         2397
 Gln Glu Pro Asn Arg Ser Leu Ser Thr Arg Leu Phe Tyr Leu 
 785                 790                 795





      <210> 556
      <211> 1488
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (544)..(1488)

      <220>
      <221> misc_feature
      <222> (1)...(1488)
      <223> n = a,t,c or g

      <400> 556
 atggcaagag atgacataaa tgtgcttacg ttaatcctta tcttctatca aattatactc     60

 agctcactga aggtagaaac tgacttctat ttcctttggt tcctacatca ccgaatacct    120

 ggattaggta taggcaatgc tcagttaaat actgccgaag cagaggtagc catagttcat    180

 gtaaatggtt ttcagaaagg gaacaccaca gaagctgtag caaacaggtt tgcagctgaa    240

 gctgctaagc aagcctccct ggaggaagaa attagactat ttagcctgat cccagacatc    300

 cctaagcacc agcgctcaat aaatattgat ttgtnnnnnn nnnnnnnnnn nnnnnnnnnn    360

 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnngggtct ctccaaagtt aaacgaagga    420

 ggcttagggt tcagaaatct tgtcttccca cggggtgaaa gtaccggtcc taaccagccg    480

 cagcaaacac cccgcgccag cagccggagc aagcggcgag agagagcacg gaccgtgaac    540

 gag  atg gac aca gta cgc aaa gac tta cct ccc act cct gca ctc acc     588
      Met Asp Thr Val Arg Lys Asp Leu Pro Pro Thr Pro Ala Leu Thr
        1               5                  10                  15

 cag ctc gtg tgt gac act ctg ggc aaa gag ttc ttt ttc ctg gac agt      636
 Gln Leu Val Cys Asp Thr Leu Gly Lys Glu Phe Phe Phe Leu Asp Ser
                  20                  25                  30

 gaa acc aga ttg tgc aaa ata gct cct gaa ggc tgg aga gag cag cct      684
 Glu Thr Arg Leu Cys Lys Ile Ala Pro Glu Gly Trp Arg Glu Gln Pro
              35                  40                  45

 cag aag acc tcc atg aat acc ttc aca ctc ttc ctg agg ata aag ttc      732
 Gln Lys Thr Ser Met Asn Thr Phe Thr Leu Phe Leu Arg Ile Lys Phe
          50                  55                  60

 ttt gtc agc cac tat ggg ctg ctc cag cac agc ctg aca agg cac cag      780
 Phe Val Ser His Tyr Gly Leu Leu Gln His Ser Leu Thr Arg His Gln
      65                  70                  75

 ttt tac ctg cag ctt cgg aaa gat atc ctg gag gag agg ctg tac tgc      828
 Phe Tyr Leu Gln Leu Arg Lys Asp Ile Leu Glu Glu Arg Leu Tyr Cys
  80                  85                  90                  95

 aat gaa gag ata ctg ctg cag ctg ggg gtc ctt gcc ttg cag gct gag      876
 Asn Glu Glu Ile Leu Leu Gln Leu Gly Val Leu Ala Leu Gln Ala Glu
                 100                 105                 110

 ttt ggc aat tac cct aag gag gtc agt acc aac ccc cta gag ttc ctg      924
 Phe Gly Asn Tyr Pro Lys Glu Val Ser Thr Asn Pro Leu Glu Phe Leu
             115                 120                 125

 gcc cca caa gtg gac cct ctg gat act ttt tcg cat cct ccc ata cct      972
 Ala Pro Gln Val Asp Pro Leu Asp Thr Phe Ser His Pro Pro Ile Pro
         130                 135                 140

 ttg gcc agc aca ggg ggc tac tcc ttg aac acc ttc atg tgc agc aat     1020
 Leu Ala Ser Thr Gly Gly Tyr Ser Leu Asn Thr Phe Met Cys Ser Asn
     145                 150                 155

 gat gcc aaa gct aag acc tcc ttg agt ccc ccg gcc agt gtc tgg att     1068
 Asp Ala Lys Ala Lys Thr Ser Leu Ser Pro Pro Ala Ser Val Trp Ile
 160                 165                 170                 175

 gtg ccc ttc cct tct aca tct tac ttc cag cag gtg gag agt aag cca     1116
 Val Pro Phe Pro Ser Thr Ser Tyr Phe Gln Gln Val Glu Ser Lys Pro
                 180                 185                 190

 tac ttt cac gtt gaa gat tac atc cca gcg agt ctg atc gag agg atg     1164
 Tyr Phe His Val Glu Asp Tyr Ile Pro Ala Ser Leu Ile Glu Arg Met
             195                 200                 205

 acc gct cta cgg gtc cag gtt gaa gtc tca gag atg cac cgg ctc agc     1212
 Thr Ala Leu Arg Val Gln Val Glu Val Ser Glu Met His Arg Leu Ser
         210                 215                 220

 tct gca ctg tgg gga gag gat gct gag ctg aag ttc ttg agg gtc act     1260
 Ser Ala Leu Trp Gly Glu Asp Ala Glu Leu Lys Phe Leu Arg Val Thr
     225                 230                 235

 cag cag ctc cca gaa tac ggt gtg ctg gtt cac caa gta ttc tca gag     1308
 Gln Gln Leu Pro Glu Tyr Gly Val Leu Val His Gln Val Phe Ser Glu
 240                 245                 250                 255

 aag agg agg cca gaa gag gag atg gcc ctg ggg atc tgt gcc aag ggt     1356
 Lys Arg Arg Pro Glu Glu Glu Met Ala Leu Gly Ile Cys Ala Lys Gly
                 260                 265                 270

 gtc ata gtc tat gaa gtg aaa aac aac agc aga att gca atg tta cgg     1404
 Val Ile Val Tyr Glu Val Lys Asn Asn Ser Arg Ile Ala Met Leu Arg
             275                 280                 285

 ttt cag tgg aga gaa acc ggg aag att tct act tat gtg agt gta gct     1452
 Phe Gln Trp Arg Glu Thr Gly Lys Ile Ser Thr Tyr Val Ser Val Ala
         290                 295                 300

 cag ttg ata aat aac ctg cac ttc att ttc ctt tga                     1488
 Gln Leu Ile Asn Asn Leu His Phe Ile Phe Leu 
     305                 310





      <210> 557
      <211> 2659
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (998)..(2659)

      <400> 557
 ttgggctgga tggcttgttt tggagacttg ggaatgtcac cctccttggg ctggatggct     60

 tcttctgggg acttggggat gtcacccttc ttgggctgga tggtttcttc tggggacttg    120

 gggatgtcac cctccttagg ctggatggct tcctctaggg acttggggat gtcaccctcc    180

 ttgggctgga tggcttcttc tggggacttg gggatgtcac cctccttggg ctggatggct    240

 tcctctaggg acttggggag gtcaccctcc ttgggctgga tggcttcttc tggggacttg    300

 gagatgtcac cctccttggg ctggctgggc ttcactgagg ccttgggaat attgcccagc    360

 ttgggctgga tgggctttgc tgaggacttg gggatgtcac cctccttggg ctggatggtt    420

 tcttctgggg acttggggat atcactctcc ttgggctggc tgggcttcac tgaggtcttg    480

 gcaatattgc ccagcttggg ctggatgggt tttgctgagg acttggggat gtcaccctct    540

 ttgggctgga tggcttcttc tgaggacttg gggaggtcct ccttcttgga ttggatggtt    600

 tcttctgggg ccttggggat gtcaccctcc ttgggctggc tgggcttcac tgaggccttg    660

 ggaatattgc ccagcttggg ctggatgggt tttgctgagg acttggggat gttactctct    720

 ttgggctgga tggctttttc tgaggacttg gggaggtcct ccttcttgga ttggatggtt    780

 tcttctgggg ccttggggat gtcaccctcc ttgggctgga tggtttcttc tgaggacttg    840

 gggctgtcat cctgcttggg atggctggtg tttgctgagg acttgggtag gtcatcgccc    900

 tcctgtgagg catcagactc ctctgtgcgc atgtggaacg tgtggctgac catggggaga    960

 aaggccttct ctttggcctg ggctatttcc aagaact atg gat gta gac aag gaa    1015
                                          Met Asp Val Asp Lys Glu
                                            1               5

 cta gga atg gaa agt gtt aaa gct gga gcc tct gga aaa cca gaa atg     1063
 Leu Gly Met Glu Ser Val Lys Ala Gly Ala Ser Gly Lys Pro Glu Met
              10                  15                  20

 agg ctg ggc act cag gaa gaa aca agt gaa ggt gat gct aat gaa agc     1111
 Arg Leu Gly Thr Gln Glu Glu Thr Ser Glu Gly Asp Ala Asn Glu Ser
          25                  30                  35

 tca tta cta gtc ctg tcc agc aac gtg cct ctc ctg gcc cta gag ttc     1159
 Ser Leu Leu Val Leu Ser Ser Asn Val Pro Leu Leu Ala Leu Glu Phe
      40                  45                  50

 ttg gaa ata gcc cag gcc aaa gag aag gcc ttt ctc ccc atg gtc agc     1207
 Leu Glu Ile Ala Gln Ala Lys Glu Lys Ala Phe Leu Pro Met Val Ser
  55                  60                  65                  70

 cac acg ttc cac atg cgc aca gag gag tct gat gcc tca cag gag ggc     1255
 His Thr Phe His Met Arg Thr Glu Glu Ser Asp Ala Ser Gln Glu Gly
                  75                  80                  85

 gat gac cta ccc aag tcc tca gca aac acc agc cat ccc aag cag gat     1303
 Asp Asp Leu Pro Lys Ser Ser Ala Asn Thr Ser His Pro Lys Gln Asp
              90                  95                 100

 gac agc ccc aag tcc tca gaa gaa acc atc cag ccc aag gag ggt gac     1351
 Asp Ser Pro Lys Ser Ser Glu Glu Thr Ile Gln Pro Lys Glu Gly Asp
         105                 110                 115

 atc ccc aag gcc cca gaa gaa acc atc caa tcc aag aag gag gac ctc     1399
 Ile Pro Lys Ala Pro Glu Glu Thr Ile Gln Ser Lys Lys Glu Asp Leu
     120                 125                 130

 ccc aag tcc tca gaa aaa gcc atc cag ccc aaa gag agt aac atc ccc     1447
 Pro Lys Ser Ser Glu Lys Ala Ile Gln Pro Lys Glu Ser Asn Ile Pro
 135                 140                 145                 150

 aag tcc tca gca aaa ccc atc cag ccc aag ctg ggc aat att ccc aag     1495
 Lys Ser Ser Ala Lys Pro Ile Gln Pro Lys Leu Gly Asn Ile Pro Lys
                 155                 160                 165

 gcc tca gtg aag ccc agc cag ccc aag gag ggt gac atc ccc aag gcc     1543
 Ala Ser Val Lys Pro Ser Gln Pro Lys Glu Gly Asp Ile Pro Lys Ala
             170                 175                 180

 cca gaa gaa acc atc caa tcc aag aag gag gac ctc ccc aag tcc tca     1591
 Pro Glu Glu Thr Ile Gln Ser Lys Lys Glu Asp Leu Pro Lys Ser Ser
         185                 190                 195

 gaa gaa gcc atc cag ccc aaa gag ggt gac atc ccc aag tcc tca gca     1639
 Glu Glu Ala Ile Gln Pro Lys Glu Gly Asp Ile Pro Lys Ser Ser Ala
     200                 205                 210

 aaa ccc atc cag ccc aag ctg ggc aat att gcc aag acc tca gtg aag     1687
 Lys Pro Ile Gln Pro Lys Leu Gly Asn Ile Ala Lys Thr Ser Val Lys
 215                 220                 225                 230

 ccc agc cag ccc aag gag agt gat atc ccc aag tcc cca gaa gaa acc     1735
 Pro Ser Gln Pro Lys Glu Ser Asp Ile Pro Lys Ser Pro Glu Glu Thr
                 235                 240                 245

 atc cag ccc aag gag ggt gac atc ccc aag tcc tca gca aag ccc atc     1783
 Ile Gln Pro Lys Glu Gly Asp Ile Pro Lys Ser Ser Ala Lys Pro Ile
             250                 255                 260

 cag ccc aag ctg ggc aat att ccc aag gcc tca gtg aag ccc agc cag     1831
 Gln Pro Lys Leu Gly Asn Ile Pro Lys Ala Ser Val Lys Pro Ser Gln
         265                 270                 275

 ccc aag gag ggt gac atc tcc aag tcc cca gaa gaa gcc atc cag ccc     1879
 Pro Lys Glu Gly Asp Ile Ser Lys Ser Pro Glu Glu Ala Ile Gln Pro
     280                 285                 290

 aag gag ggt gac ctc ccc aag tcc cta gag gaa gcc atc cag ccc aag     1927
 Lys Glu Gly Asp Leu Pro Lys Ser Leu Glu Glu Ala Ile Gln Pro Lys
 295                 300                 305                 310

 gag ggt gac atc ccc aag tcc cca gaa gaa gcc atc cag ccc aag gag     1975
 Glu Gly Asp Ile Pro Lys Ser Pro Glu Glu Ala Ile Gln Pro Lys Glu
                 315                 320                 325

 ggt gac atc ccc aag tcc cta gag gaa gcc atc cag cct aag gag ggt     2023
 Gly Asp Ile Pro Lys Ser Leu Glu Glu Ala Ile Gln Pro Lys Glu Gly
             330                 335                 340

 gac atc ccc aag tcc cca gaa gaa acc atc cag ccc aag aag ggt gac     2071
 Asp Ile Pro Lys Ser Pro Glu Glu Thr Ile Gln Pro Lys Lys Gly Asp
         345                 350                 355

 atc ccc aag tcc cca gaa gaa gcc atc cag ccc aag gag ggt gac att     2119
 Ile Pro Lys Ser Pro Glu Glu Ala Ile Gln Pro Lys Glu Gly Asp Ile
     360                 365                 370

 ccc aag tct cca aaa caa gcc atc cag ccc aag gag ggt gac att ccc     2167
 Pro Lys Ser Pro Lys Gln Ala Ile Gln Pro Lys Glu Gly Asp Ile Pro
 375                 380                 385                 390

 aag tcc cta gag gaa gcc atc cca ccc aag gag att gac atc ccc aag     2215
 Lys Ser Leu Glu Glu Ala Ile Pro Pro Lys Glu Ile Asp Ile Pro Lys
                 395                 400                 405

 tcc cca gaa gaa acc atc cag ccc aag gag gat gac agc ccc aag tcc     2263
 Ser Pro Glu Glu Thr Ile Gln Pro Lys Glu Asp Asp Ser Pro Lys Ser
             410                 415                 420

 cta gaa gaa gcc acc cca tcc aag gag ggt gac atc cta aag cct gaa     2311
 Leu Glu Glu Ala Thr Pro Ser Lys Glu Gly Asp Ile Leu Lys Pro Glu
         425                 430                 435

 gaa gaa aca atg gag ttc ccg gag ggg gac aag gtg aaa gtg atc ctg     2359
 Glu Glu Thr Met Glu Phe Pro Glu Gly Asp Lys Val Lys Val Ile Leu
     440                 445                 450

 agc aag gag gac ttt gag gca tca ctg aag gag gcc ggg gag agg ctg     2407
 Ser Lys Glu Asp Phe Glu Ala Ser Leu Lys Glu Ala Gly Glu Arg Leu
 455                 460                 465                 470

 gtg gct gtg gac ttc tcg gcc acg tgg tgt ggg ccc tgc agg acc atc     2455
 Val Ala Val Asp Phe Ser Ala Thr Trp Cys Gly Pro Cys Arg Thr Ile
                 475                 480                 485

 aga cca ttc ttc cat gcc ctg tct gtg aag cat gag gat gtg gtg ttc     2503
 Arg Pro Phe Phe His Ala Leu Ser Val Lys His Glu Asp Val Val Phe
             490                 495                 500

 ctg gag gtg gac gct gac aac tgt gag gag gtg gtg aga gag tgc gcc     2551
 Leu Glu Val Asp Ala Asp Asn Cys Glu Glu Val Val Arg Glu Cys Ala
         505                 510                 515

 atc atg tgt gtc cca acc ttt cag ttt tat aaa aaa gaa gaa aag gtg     2599
 Ile Met Cys Val Pro Thr Phe Gln Phe Tyr Lys Lys Glu Glu Lys Val
     520                 525                 530

 gat gaa ctt tgc ggc gcc ctt aag gaa aaa ctt gaa gca gtc att gca     2647
 Asp Glu Leu Cys Gly Ala Leu Lys Glu Lys Leu Glu Ala Val Ile Ala
 535                 540                 545                 550

 gaa tta aag taa                                                     2659
 Glu Leu Lys 






      <210> 558
      <211> 918
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (14)..(886)

      <400> 558
 ccggcacctg gcc   atg tgc aac cct gag gag gca gct ctg ctg cgg ctg      49
                  Met Cys Asn Pro Glu Glu Ala Ala Leu Leu Arg Leu
                    1               5                  10

 gag gag gtc ttc tca gcc acc ctc gcc cat gtc aac agc ctt gtc ctc       97
 Glu Glu Val Phe Ser Ala Thr Leu Ala His Val Asn Ser Leu Val Leu
          15                  20                  25

 cag ccc ctg ctc cca gcc gcc cca gat ccc tcg gat ccc tgg ggc aga      145
 Gln Pro Leu Leu Pro Ala Ala Pro Asp Pro Ser Asp Pro Trp Gly Arg
      30                  35                  40

 gag tgc ctg cgg ctc ttg caa cag ctg cac aag agc tcc cag caa ctc      193
 Glu Cys Leu Arg Leu Leu Gln Gln Leu His Lys Ser Ser Gln Gln Leu
  45                  50                  55                  60

 tgg gag gtg acg gag gaa agc ctg cac tca ctg cag gag agg ctg cgt      241
 Trp Glu Val Thr Glu Glu Ser Leu His Ser Leu Gln Glu Arg Leu Arg
                  65                  70                  75

 tac ccg gac tcc acc ggt ctg gag tcc ctg ctg ctg ctg cga ggt gct      289
 Tyr Pro Asp Ser Thr Gly Leu Glu Ser Leu Leu Leu Leu Arg Gly Ala
              80                  85                  90

 gac cgt gta ctg cag gcc cac ata gag tac att gag tcc tac aca agc      337
 Asp Arg Val Leu Gln Ala His Ile Glu Tyr Ile Glu Ser Tyr Thr Ser
          95                 100                 105

 tgc atg gtg gtg cag gcc ttc cag aag gca gca aag agg aga agc gag      385
 Cys Met Val Val Gln Ala Phe Gln Lys Ala Ala Lys Arg Arg Ser Glu
     110                 115                 120

 tac tgg cgg ggc cag cgg aag gcg ctg cgg cag ctg ctt tca ggt gtg      433
 Tyr Trp Arg Gly Gln Arg Lys Ala Leu Arg Gln Leu Leu Ser Gly Val
 125                 130                 135                 140

 agc tca gag ggc tcg gtg ggc gca tcg ctg ggc cag gcc ctc cac cag      481
 Ser Ser Glu Gly Ser Val Gly Ala Ser Leu Gly Gln Ala Leu His Gln
                 145                 150                 155

 cca ctc gcc cat cac gtg caa cag tac gtg ctc ctc ctg ctg agc ctc      529
 Pro Leu Ala His His Val Gln Gln Tyr Val Leu Leu Leu Leu Ser Leu
             160                 165                 170

 ggg gac acc att ggg gag cat cac cca acc cgg gag ctg gtg gtg aac      577
 Gly Asp Thr Ile Gly Glu His His Pro Thr Arg Glu Leu Val Val Asn
         175                 180                 185

 gca gtc acc ctc ttt ggg aac ctg cag tcc ttc atg aag cag gag ttg      625
 Ala Val Thr Leu Phe Gly Asn Leu Gln Ser Phe Met Lys Gln Glu Leu
     190                 195                 200

 gac cag gct gtg gcc aca cag gct ctc tgg cac acc ctg aga ggc cgg      673
 Asp Gln Ala Val Ala Thr Gln Ala Leu Trp His Thr Leu Arg Gly Arg
 205                 210                 215                 220

 ctg agg gat gtg ctc tgc acc cct gct cac aga ctc ctt cag gac agc      721
 Leu Arg Asp Val Leu Cys Thr Pro Ala His Arg Leu Leu Gln Asp Ser
                 225                 230                 235

 cag gac gta ccc gtg acg gtc gca ccg gtt cag tcg ctt gca gca gcc      769
 Gln Asp Val Pro Val Thr Val Ala Pro Val Gln Ser Leu Ala Ala Ala
             240                 245                 250

 cgg gga aca ggc ctg tct ggc cct gag gga gtc ccc ttt ctg aag ctg      817
 Arg Gly Thr Gly Leu Ser Gly Pro Glu Gly Val Pro Phe Leu Lys Leu
         255                 260                 265

 tgg tgc ttg ggc gac ctg ctc tct aca ttg ctg ggc acc tgt agg tgt      865
 Trp Cys Leu Gly Asp Leu Leu Ser Thr Leu Leu Gly Thr Cys Arg Cys
     270                 275                 280

 ccc tcg aga gct cag ttt tga gg ttcaagtcag tgtggccatg aaggggctgc      918
 Pro Ser Arg Ala Gln Phe 
 285                 290





      <210> 559
      <211> 216
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (36)..(197)

      <400> 559
 aggcgaatga aattgtccta tcctggaact gctgg   atg ctt tgc aag cag tat      53
                                          Met Leu Cys Lys Gln Tyr
                                            1               5

 atg ttt gaa gtg gca atc atg agg gag gat gaa gct gtg aag aga ctc      101
 Met Phe Glu Val Ala Ile Met Arg Glu Asp Glu Ala Val Lys Arg Leu
              10                  15                  20

 tta aga act gca ctg gaa ttg gat cca cac tct gaa ctt gac caa aag      149
 Leu Arg Thr Ala Leu Glu Leu Asp Pro His Ser Glu Leu Asp Gln Lys
          25                  30                  35

 ctg cag aag cac ata atg aaa aac ctt ttg aag aag ctt att tcc tag      197
 Leu Gln Lys His Ile Met Lys Asn Leu Leu Lys Lys Leu Ile Ser 
      40                  45                  50

 ttcttgaatc ctcatagag                                                 216




      <210> 560
      <211> 1394
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (3)..(1274)

      <400> 560
 ga   atg ata tgg gaa gaa cag aat act gaa gat cag tac aaa aat cct      47
      Met Ile Trp Glu Glu Gln Asn Thr Glu Asp Gln Tyr Lys Asn Pro
        1               5                  10                  15

 agg aga aat cta aga tgt cat atg gta gag aga ttc agt gaa agt aaa       95
 Arg Arg Asn Leu Arg Cys His Met Val Glu Arg Phe Ser Glu Ser Lys
                  20                  25                  30

 gac agt agt cag tgt gga gaa aca ttt agc ctc att cga gat agt att      143
 Asp Ser Ser Gln Cys Gly Glu Thr Phe Ser Leu Ile Arg Asp Ser Ile
              35                  40                  45

 gtg aac aac agc att tgt cct gga gaa gat cca tgt caa agc gct gag      191
 Val Asn Asn Ser Ile Cys Pro Gly Glu Asp Pro Cys Gln Ser Ala Glu
          50                  55                  60

 tgt gaa gaa gtc ata atg ggt cat tta tcc ctt aat agc cac atc aga      239
 Cys Glu Glu Val Ile Met Gly His Leu Ser Leu Asn Ser His Ile Arg
      65                  70                  75

 gtt gat tct gga cac aaa cca cat gag tat cag gaa tat gga gag aag      287
 Val Asp Ser Gly His Lys Pro His Glu Tyr Gln Glu Tyr Gly Glu Lys
  80                  85                  90                  95

 cca cat aca cat aaa caa cgt ggg aaa gcc ctc agt tac cat cac tcc      335
 Pro His Thr His Lys Gln Arg Gly Lys Ala Leu Ser Tyr His His Ser
                 100                 105                 110

 ttt cag tcg cgt gga agg cct cac act gga aag aaa cgc tat gag tgt      383
 Phe Gln Ser Arg Gly Arg Pro His Thr Gly Lys Lys Arg Tyr Glu Cys
             115                 120                 125

 aag gaa tgt gga aaa acc ttc agt tct cgt aga aac ctt cga aga cac      431
 Lys Glu Cys Gly Lys Thr Phe Ser Ser Arg Arg Asn Leu Arg Arg His
         130                 135                 140

 atg gta gtg caa ggt gga aat aga cct tat aaa tgt aag ttg tgt ggg      479
 Met Val Val Gln Gly Gly Asn Arg Pro Tyr Lys Cys Lys Leu Cys Gly
     145                 150                 155

 aaa gct ttt ttt tgg ccc agt tta tta cgt atg cat gaa aga act cac      527
 Lys Ala Phe Phe Trp Pro Ser Leu Leu Arg Met His Glu Arg Thr His
 160                 165                 170                 175

 act gga gag aaa ccg tat gaa tgt aag cag tgt tct aaa gcc ttt cct      575
 Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Ser Lys Ala Phe Pro
                 180                 185                 190

 ttt tac agt tcc tat cga aga cat gag aga atg cac act ggg gag aaa      623
 Phe Tyr Ser Ser Tyr Arg Arg His Glu Arg Met His Thr Gly Glu Lys
             195                 200                 205

 ccg tat gaa tgt aag cag tgt tct aaa gcc ttg cct gat tcc agt tcc      671
 Pro Tyr Glu Cys Lys Gln Cys Ser Lys Ala Leu Pro Asp Ser Ser Ser
         210                 215                 220

 tat ata aga cat gaa aga act cac act gga gag aaa cca tat aca tgt      719
 Tyr Ile Arg His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr Thr Cys
     225                 230                 235

 aaa cag tgt ggg aaa gcc ttc agt gtt tcc agt tcc ctt cga aga cat      767
 Lys Gln Cys Gly Lys Ala Phe Ser Val Ser Ser Ser Leu Arg Arg His
 240                 245                 250                 255

 gaa acc act cac agt gca gag aaa ccc tat gag tgt aag caa tgc ggg      815
 Glu Thr Thr His Ser Ala Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly
                 260                 265                 270

 aaa aca ttt cat cat ctt gga agc ttt cag ata cac atg aaa agg cac      863
 Lys Thr Phe His His Leu Gly Ser Phe Gln Ile His Met Lys Arg His
             275                 280                 285

 act gga gat cga cct cat aaa tgt aag ata tgt ggg aaa ggc ttt gat      911
 Thr Gly Asp Arg Pro His Lys Cys Lys Ile Cys Gly Lys Gly Phe Asp
         290                 295                 300

 cgt ccc agt tta gtt cga tat cat gaa cga att cac act gga gag aaa      959
 Arg Pro Ser Leu Val Arg Tyr His Glu Arg Ile His Thr Gly Glu Lys
     305                 310                 315

 ccc tat gaa tgc aag cag tgt ggg aaa acg tta tct cat agc tca agc     1007
 Pro Tyr Glu Cys Lys Gln Cys Gly Lys Thr Leu Ser His Ser Ser Ser
 320                 325                 330                 335

 ttt cga aga cac atg ata atg cac act gga ggt gga cct cat aaa tgc     1055
 Phe Arg Arg His Met Ile Met His Thr Gly Gly Gly Pro His Lys Cys
                 340                 345                 350

 aag ata tgt ggg aaa gct ttt gtt tat cct agt gta tgt caa aga cac     1103
 Lys Ile Cys Gly Lys Ala Phe Val Tyr Pro Ser Val Cys Gln Arg His
             355                 360                 365

 gaa aag tct cac agt gga gag aaa ccc tat gaa tgc aag cag tgt ggg     1151
 Glu Lys Ser His Ser Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly
         370                 375                 380

 aaa gcg tta tct cat agc tca agc ttt cga aga cat atg gta atg cat     1199
 Lys Ala Leu Ser His Ser Ser Ser Phe Arg Arg His Met Val Met His
     385                 390                 395

 acg gga gat ggg ccg aat aaa tgc aag gta tgt ggg aaa gcc ttt gtt     1247
 Thr Gly Asp Gly Pro Asn Lys Cys Lys Val Cys Gly Lys Ala Phe Val
 400                 405                 410                 415

 tat ccc agt gta tgt caa agc aca tga aaagc tgcctgctgg tgcacacgct     1299
 Tyr Pro Ser Val Cys Gln Ser Thr 
                 420

 tccctgaata ccaaactccc agactgagca catgggtggc catgtgcaag cgctacagcc   1359

 tcagcacatt gctgagcaca catgcatcct cctga                              1394




      <210> 561
      <211> 658
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (311)..(640)

      <400> 561
 acagagtctc cttagagtgc cgtgggaagc tggctataaa gtatctaagg aagaggcaca     60

 gatctgtggc caaggagttt ggtatcttgg cttttatgtc tcccaagggc agtgtgagct    120

 tggacaggag tgaaaagaga ttgtctgtag cgttcctcag ccagacacaa ggtggcaagt    180

 gtgggaattc ctaggggcag ctgctttttg ccacatatgg attcctaact actcgctcct    240

 agcaaagcct ttatatgagg caaccaaagt gggagaaaaa gagcccctcc tttggggaaa    300

 agaacaggac   atg gct ttc aag gaa atc aag aaa gct tta acc tgg gcc     349
              Met Ala Phe Lys Glu Ile Lys Lys Ala Leu Thr Trp Ala
                1               5                  10

 cca gca cta gga ctg cca gac atg aca aag ccc ttt tac ttg tat gtt      397
 Pro Ala Leu Gly Leu Pro Asp Met Thr Lys Pro Phe Tyr Leu Tyr Val
      15                  20                  25

 cat gaa aga aaa ggt atg gct aca gga gtc tta gtg caa aca cta gag      445
 His Glu Arg Lys Gly Met Ala Thr Gly Val Leu Val Gln Thr Leu Glu
  30                  35                  40                  45

 tca tgg tat tgg cct gta gcg tat ttg tcc aag caa ctg gac ttg gtg      493
 Ser Trp Tyr Trp Pro Val Ala Tyr Leu Ser Lys Gln Leu Asp Leu Val
                  50                  55                  60

 gct atg gga tgg cca ccc tgt ttc aag gcc ctg gct gcc act gcc ttg      541
 Ala Met Gly Trp Pro Pro Cys Phe Lys Ala Leu Ala Ala Thr Ala Leu
              65                  70                  75

 tta gcc gaa gat gct aac aag ctc aca ttt gga cag aag ttg ata att      589
 Leu Ala Glu Asp Ala Asn Lys Leu Thr Phe Gly Gln Lys Leu Ile Ile
          80                  85                  90

 cgt gtg ccc cac aca gtt gtc acc ttg atg gaa cag aga gga cat cgt      637
 Arg Val Pro His Thr Val Val Thr Leu Met Glu Gln Arg Gly His Arg
      95                 100                 105

 tga ctctctaacc ctaggatg                                              658
 






      <210> 562
      <211> 1998
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1998)

      <400> 562
  atg cag caa gaa ggc acc att tat gag gaa gca aga acc tca cca gac      48
  Met Gln Gln Glu Gly Thr Ile Tyr Glu Glu Ala Arg Thr Ser Pro Asp
    1               5                  10                  15

 act gaa tct gtg ggt gct ttg atg gga ctt ctc agc ctg cag aac tat       96
 Thr Glu Ser Val Gly Ala Leu Met Gly Leu Leu Ser Leu Gln Asn Tyr
              20                  25                  30

 ttg aag caa att aaa ata gac cta ggt aaa ttc tca gat aac cct gat      144
 Leu Lys Gln Ile Lys Ile Asp Leu Gly Lys Phe Ser Asp Asn Pro Asp
          35                  40                  45

 ggc tat gtt gat gtt tta caa ggg tta gga caa tcc ttt gat ctg aca      192
 Gly Tyr Val Asp Val Leu Gln Gly Leu Gly Gln Ser Phe Asp Leu Thr
      50                  55                  60

 tgg aga gat ata atg tta ctg cta gat cag aca cta acc cca aac aag      240
 Trp Arg Asp Ile Met Leu Leu Leu Asp Gln Thr Leu Thr Pro Asn Lys
  65                  70                  75                  80

 aga agt gcc gcc ata act gta gcc cga gag ttt ggc gat ctc tgg tat      288
 Arg Ser Ala Ala Ile Thr Val Ala Arg Glu Phe Gly Asp Leu Trp Tyr
                  85                  90                  95

 ctc aat cag gtc aat gat agt atg aca aca gag gaa aga gaa caa ttc      336
 Leu Asn Gln Val Asn Asp Ser Met Thr Thr Glu Glu Arg Glu Gln Phe
             100                 105                 110

 ccc aca ggc cag cag tac cct ctt aga tcc acc cag ctc tct gat gga      384
 Pro Thr Gly Gln Gln Tyr Pro Leu Arg Ser Thr Gln Leu Ser Asp Gly
         115                 120                 125

 cag ccc aac aag ccc caa ctt gga ctt caa aag atc gtt aag gac cta      432
 Gln Pro Asn Lys Pro Gln Leu Gly Leu Gln Lys Ile Val Lys Asp Leu
     130                 135                 140

 aaa gcc caa ggc cta gta aaa cca tgc aat agt ccc tgc aat act cca      480
 Lys Ala Gln Gly Leu Val Lys Pro Cys Asn Ser Pro Cys Asn Thr Pro
 145                 150                 155                 160

 att tta gga gta cag aaa ccc aat gga cag tgg agg tta gtg caa gat      528
 Ile Leu Gly Val Gln Lys Pro Asn Gly Gln Trp Arg Leu Val Gln Asp
                 165                 170                 175

 ctc agg att atc agt gag gcc gtt gtc cct cta tac cca gct gta cct      576
 Leu Arg Ile Ile Ser Glu Ala Val Val Pro Leu Tyr Pro Ala Val Pro
             180                 185                 190

 aac cct tat act ttg ctt tca caa ata cca gag gaa gca gag tgg ttt      624
 Asn Pro Tyr Thr Leu Leu Ser Gln Ile Pro Glu Glu Ala Glu Trp Phe
         195                 200                 205

 aca gtc ctg gat ctt aag gat gcc ttt ttc tgc atc ccc gta cat ccc      672
 Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Ile Pro Val His Pro
     210                 215                 220

 gac tct caa ttc ttg ttt gcc ttt gaa gat cct ttg aac cca aca tct      720
 Asp Ser Gln Phe Leu Phe Ala Phe Glu Asp Pro Leu Asn Pro Thr Ser
 225                 230                 235                 240

 caa ctc acc tgg act gct tta ccc caa gtg ttc agg gat agc ccc cat      768
 Gln Leu Thr Trp Thr Ala Leu Pro Gln Val Phe Arg Asp Ser Pro His
                 245                 250                 255

 cta ttt gac cag gca tta gca caa gac ttg agc cag ttc tca tac ttg      816
 Leu Phe Asp Gln Ala Leu Ala Gln Asp Leu Ser Gln Phe Ser Tyr Leu
             260                 265                 270

 gac act ctt gcc ctt tgg tat gtg gat gat tta ctt tta gca gcc cgt      864
 Asp Thr Leu Ala Leu Trp Tyr Val Asp Asp Leu Leu Leu Ala Ala Arg
         275                 280                 285

 tca gaa acc ttg tgc cat cga gtt acc caa gcg ctc tta aac ttc ctc      912
 Ser Glu Thr Leu Cys His Arg Val Thr Gln Ala Leu Leu Asn Phe Leu
     290                 295                 300

 gcc acc tgt ggc tac aag gtt tcc aaa cca aag gct cag ttc tgc tta      960
 Ala Thr Cys Gly Tyr Lys Val Ser Lys Pro Lys Ala Gln Phe Cys Leu
 305                 310                 315                 320

 cag cag gtt aaa tac tta ggg cta aaa tta tcc aaa ggc acc agg gcc     1008
 Gln Gln Val Lys Tyr Leu Gly Leu Lys Leu Ser Lys Gly Thr Arg Ala
                 325                 330                 335

 ctc atg tcg ccg tcc agc ctg gtt gtt gaa gcg tcc ccg tgg tcc ccc     1056
 Leu Met Ser Pro Ser Ser Leu Val Val Glu Ala Ser Pro Trp Ser Pro
             340                 345                 350

 ggg gtc cag gcc cct ttg tgg agg cag ctg ctg gcc ccc agc cca tgg     1104
 Gly Val Gln Ala Pro Leu Trp Arg Gln Leu Leu Ala Pro Ser Pro Trp
         355                 360                 365

 gac cgt agt cgc gga ggc ctc tgc aga ggc gca ggc tgg aag cgg tgg     1152
 Asp Arg Ser Arg Gly Gly Leu Cys Arg Gly Ala Gly Trp Lys Arg Trp
     370                 375                 380

 cct ttg agg ggg gcg gca gga gag agt acc gac ctc cct cga act cct     1200
 Pro Leu Arg Gly Ala Ala Gly Glu Ser Thr Asp Leu Pro Arg Thr Pro
 385                 390                 395                 400

 ggc aga ggt ggg ggt cgc agc aaa agc act ggg gtg gag ggc ggc cag     1248
 Gly Arg Gly Gly Gly Arg Ser Lys Ser Thr Gly Val Glu Gly Gly Gln
                 405                 410                 415

 tgt ggg gca gac gcc tgt gtg cct tcc tca gat acg ggc aga gtt gtg     1296
 Cys Gly Ala Asp Ala Cys Val Pro Ser Ser Asp Thr Gly Arg Val Val
             420                 425                 430

 gat gtg aga agg gtc tgg ctt ggg tac ctc agt tcc aaa cct cct gtg     1344
 Asp Val Arg Arg Val Trp Leu Gly Tyr Leu Ser Ser Lys Pro Pro Val
         435                 440                 445

 tcc atc aga gag ctg gcg gtc acc atg gca atg cgg gag ctg gtg gag     1392
 Ser Ile Arg Glu Leu Ala Val Thr Met Ala Met Arg Glu Leu Val Glu
     450                 455                 460

 gcc gaa tgc ggg ggt gcc aac ccg ctc atg aag ctc gcc ggg cac ttc     1440
 Ala Glu Cys Gly Gly Ala Asn Pro Leu Met Lys Leu Ala Gly His Phe
 465                 470                 475                 480

 acc cag gac aag gcc ctt cgg cag gag gga ttg agg cct ggc ccc tgg     1488
 Thr Gln Asp Lys Ala Leu Arg Gln Glu Gly Leu Arg Pro Gly Pro Trp
                 485                 490                 495

 ccc ccc gga gcc ccg gcc tct gag gca gtg agt gtt ctt gag gtg gaa     1536
 Pro Pro Gly Ala Pro Ala Ser Glu Ala Val Ser Val Leu Glu Val Glu
             500                 505                 510

 agc cca ggt gca gcc tct gag gca gtg agt gtt ctt gag gtg gaa agc     1584
 Ser Pro Gly Ala Ala Ser Glu Ala Val Ser Val Leu Glu Val Glu Ser
         515                 520                 525

 cca ggt gca gcc tct gag gca gcc tcc aag cct ttg gga gta gct tct     1632
 Pro Gly Ala Ala Ser Glu Ala Ala Ser Lys Pro Leu Gly Val Ala Ser
     530                 535                 540

 gaa gat gaa ttg gtg ggt gaa ttc ctg cag gac cac agt gta ccc ttg     1680
 Glu Asp Glu Leu Val Gly Glu Phe Leu Gln Asp His Ser Val Pro Leu
 545                 550                 555                 560

 tat ccc gtg ccc ctc aga cct tca aga tgg atg aac tcc tgg ctg aga     1728
 Tyr Pro Val Pro Leu Arg Pro Ser Arg Trp Met Asn Ser Trp Leu Arg
                 565                 570                 575

 tgc agc aga ctg aag agt caa act tcc tcc agg ctc ccc aga gag ccc     1776
 Cys Ser Arg Leu Lys Ser Gln Thr Ser Ser Arg Leu Pro Arg Glu Pro
             580                 585                 590

 ctg gtg tgg ccg act tgg cct tgt ctg aga act ggg ccc aga gtg act     1824
 Leu Val Trp Pro Thr Trp Pro Cys Leu Arg Thr Gly Pro Arg Val Thr
         595                 600                 605

 tgc agc tgg aga tgc aga aga cac agg ctg gtc tgc atg gcc ctt ttc     1872
 Cys Ser Trp Arg Cys Arg Arg His Arg Leu Val Cys Met Ala Leu Phe
     610                 615                 620

 tct ggg gag gct ctt ggg gag cgg ctg gtg ttg cga agg ctc tgg tat     1920
 Ser Gly Glu Ala Leu Gly Glu Arg Leu Val Leu Arg Arg Leu Trp Tyr
 625                 630                 635                 640

 cac ctc tca tgc ctg aac aag aga atg acc gtg tac ata ctg gac agc     1968
 His Leu Ser Cys Leu Asn Lys Arg Met Thr Val Tyr Ile Leu Asp Ser
                 645                 650                 655

 agc atg att cct gaa aag aaa ata ttc tga                             1998
 Ser Met Ile Pro Glu Lys Lys Ile Phe 
             660                 665





      <210> 563
      <211> 1497
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1497)

      <400> 563
  atg agg agg tac act aca ctc aaa aag aac tgc ttg agt ttt gta act      48
  Met Arg Arg Tyr Thr Thr Leu Lys Lys Asn Cys Leu Ser Phe Val Thr
    1               5                  10                  15

 tat ata aca gaa atc tgg ata aca ggc atg gga atg tat att aag gga       96
 Tyr Ile Thr Glu Ile Trp Ile Thr Gly Met Gly Met Tyr Ile Lys Gly
              20                  25                  30

 gac ctc ctg cct ttt acc agg gca act gtg cac tgg gga aag gga tat      144
 Asp Leu Leu Pro Phe Thr Arg Ala Thr Val His Trp Gly Lys Gly Tyr
          35                  40                  45

 gat cgg aca ttt tgg gga cta cta gac act ggc tct gag ctg aca ttg      192
 Asp Arg Thr Phe Trp Gly Leu Leu Asp Thr Gly Ser Glu Leu Thr Leu
      50                  55                  60

 act cca ggg gac cca aaa cat cat tgt ggt ccc cca gtt aaa gta ggg      240
 Thr Pro Gly Asp Pro Lys His His Cys Gly Pro Pro Val Lys Val Gly
  65                  70                  75                  80

 gtt tat gaa aat cag act cat cct gtg gtc att tct cca gtg cca aaa      288
 Val Tyr Glu Asn Gln Thr His Pro Val Val Ile Ser Pro Val Pro Lys
                  85                  90                  95

 tgc ata att ggc ata gac ata ctt agc agc tgg cag aac acc cat gtt      336
 Cys Ile Ile Gly Ile Asp Ile Leu Ser Ser Trp Gln Asn Thr His Val
             100                 105                 110

 agc gcc ctg act gga tat cac act gtt cat tac att gat gac att ata      384
 Ser Ala Leu Thr Gly Tyr His Thr Val His Tyr Ile Asp Asp Ile Ile
         115                 120                 125

 ctg att gga tcc agt gaa caa gaa gta gca gac aca ctg gac tta ttg      432
 Leu Ile Gly Ser Ser Glu Gln Glu Val Ala Asp Thr Leu Asp Leu Leu
     130                 135                 140

 gtg aag aat aag ttg ctg cat ttg gcc cct cct aca acc aag aaa ggc      480
 Val Lys Asn Lys Leu Leu His Leu Ala Pro Pro Thr Thr Lys Lys Gly
 145                 150                 155                 160

 aca aca ccc aaa cag gag aag gct ctg caa cag gtc cag gct gct gtg      528
 Thr Thr Pro Lys Gln Glu Lys Ala Leu Gln Gln Val Gln Ala Ala Val
                 165                 170                 175

 caa gct gct ctg cca ctt ggg ccc tat gac cca gca gat cca atg gta      576
 Gln Ala Ala Leu Pro Leu Gly Pro Tyr Asp Pro Ala Asp Pro Met Val
             180                 185                 190

 ctt gag gtg tca ctg gca gat agg gat gct gtt tgg agc ctt tgg cag      624
 Leu Glu Val Ser Leu Ala Asp Arg Asp Ala Val Trp Ser Leu Trp Gln
         195                 200                 205

 gcc ccc tta gcc aca cct gtc att gcc caa tgg gcc cat gaa caa agt      672
 Ala Pro Leu Ala Thr Pro Val Ile Ala Gln Trp Ala His Glu Gln Ser
     210                 215                 220

 ggc cat ggt ggt agg gat gga ggt tat gca tgg gct cag cag ctt gga      720
 Gly His Gly Gly Arg Asp Gly Gly Tyr Ala Trp Ala Gln Gln Leu Gly
 225                 230                 235                 240

 ctt cca ctc acc aag gct gac ctg gct aca gcc gct gct gag tgc cca      768
 Leu Pro Leu Thr Lys Ala Asp Leu Ala Thr Ala Ala Ala Glu Cys Pro
                 245                 250                 255

 att tgc cag cag cag aga cca aca ctg agc cct caa tat ggc acc att      816
 Ile Cys Gln Gln Gln Arg Pro Thr Leu Ser Pro Gln Tyr Gly Thr Ile
             260                 265                 270

 cct cgt gct gct acc tgg att cac ggg tcc agg aat caa ggg gtg gaa      864
 Pro Arg Ala Ala Thr Trp Ile His Gly Ser Arg Asn Gln Gly Val Glu
         275                 280                 285

 gtg gaa gtg gca cca ctc acc atc acc tct agt gat cca cta gga aaa      912
 Val Glu Val Ala Pro Leu Thr Ile Thr Ser Ser Asp Pro Leu Gly Lys
     290                 295                 300

 ttt tta ctt cct gtt ccc atg ata tta cat tct gct ggc cta gag gtc      960
 Phe Leu Leu Pro Val Pro Met Ile Leu His Ser Ala Gly Leu Glu Val
 305                 310                 315                 320

 tta gtt cca gag gga gga aca ctg cca cca gga gac aca aca aca att     1008
 Leu Val Pro Glu Gly Gly Thr Leu Pro Pro Gly Asp Thr Thr Thr Ile
                 325                 330                 335

 cca tta aac tgg aaa tta aga ttg cca cct gga cac ttc ggg ctc ctc     1056
 Pro Leu Asn Trp Lys Leu Arg Leu Pro Pro Gly His Phe Gly Leu Leu
             340                 345                 350

 cta cct tta agt caa cag gct aag agg gga gtt aca gtg ttg gat ggg     1104
 Leu Pro Leu Ser Gln Gln Ala Lys Arg Gly Val Thr Val Leu Asp Gly
         355                 360                 365

 aca att gat ctg gac tat caa gat gaa atc agt cta cta ctt cat aat     1152
 Thr Ile Asp Leu Asp Tyr Gln Asp Glu Ile Ser Leu Leu Leu His Asn
     370                 375                 380

 gga gaa ctt cca aaa ttt ctc tat gaa aag cag agc caa cca gaa cca     1200
 Gly Glu Leu Pro Lys Phe Leu Tyr Glu Lys Gln Ser Gln Pro Glu Pro
 385                 390                 395                 400

 cct gga agt ggg gtg ccc agc cat cct gag aga aga ctt ggt cca cta     1248
 Pro Gly Ser Gly Val Pro Ser His Pro Glu Arg Arg Leu Gly Pro Leu
                 405                 410                 415

 gag aaa gtg ccc tca cag aaa gtc ttc ttc ctc ctc cct tat cgc ctg     1296
 Glu Lys Val Pro Ser Gln Lys Val Phe Phe Leu Leu Pro Tyr Arg Leu
             420                 425                 430

 gac caa ttt tct aaa caa ttt ctt tgc cag cga cat tat gtt gca gaa     1344
 Asp Gln Phe Ser Lys Gln Phe Leu Cys Gln Arg His Tyr Val Ala Glu
         435                 440                 445

 aat gga cga gct agc tgg gat gtg gac agg act tgt gac tta cct cta     1392
 Asn Gly Arg Ala Ser Trp Asp Val Asp Arg Thr Cys Asp Leu Pro Leu
     450                 455                 460

 gca atg gaa tgt ggc aga ggt gat aga atg tta ctt cag tgt gat tat     1440
 Ala Met Glu Cys Gly Arg Gly Asp Arg Met Leu Leu Gln Cys Asp Tyr
 465                 470                 475                 480

 gtc cct ctt gct ggc aga ctt att cta gga act ctg tgg cag acc tta     1488
 Val Pro Leu Ala Gly Arg Leu Ile Leu Gly Thr Leu Trp Gln Thr Leu
                 485                 490                 495

 aag aag taa                                                         1497
 Lys Lys 






      <210> 564
      <211> 743
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (52)..(558)

      <400> 564
 gttagaaccg tcggccagtg cattgaattt aggtgacact atagaagagc t atg acg      57
                                                          Met Thr
                                                            1

 tcg cat gca cgc gta cgt aag ctt gga tcc tct aga gcg gcg cct act      105
 Ser His Ala Arg Val Arg Lys Leu Gly Ser Ser Arg Ala Ala Pro Thr
           5                  10                  15

 act act ata cgg ctg cga gaa gac gac aga agg gag agt gga ttt ggc      153
 Thr Thr Ile Arg Leu Arg Glu Asp Asp Arg Arg Glu Ser Gly Phe Gly
      20                  25                  30

 tgg gcc atc tgg atg gaa ggt ctg gtc ttc tct cgt ctg agc cct gag      201
 Trp Ala Ile Trp Met Glu Gly Leu Val Phe Ser Arg Leu Ser Pro Glu
  35                  40                  45                  50

 tac tac gac ctg gca aga gcc cac ctg cgt gat gag gag aaa tcc tgc      249
 Tyr Tyr Asp Leu Ala Arg Ala His Leu Arg Asp Glu Glu Lys Ser Cys
                  55                  60                  65

 ccg tgc ctg gcc cag gag ggc ccc cag ggt gac ctg ttg acc aaa aca      297
 Pro Cys Leu Ala Gln Glu Gly Pro Gln Gly Asp Leu Leu Thr Lys Thr
              70                  75                  80

 cag gag ctg ggc cgt gac tac agg acc tgt ctg acg ata gtc caa aaa      345
 Gln Glu Leu Gly Arg Asp Tyr Arg Thr Cys Leu Thr Ile Val Gln Lys
          85                  90                  95

 ctg aag aag atg gtg gat aag ccc acc cag aga agt gtt tcc aat gct      393
 Leu Lys Lys Met Val Asp Lys Pro Thr Gln Arg Ser Val Ser Asn Ala
     100                 105                 110

 gcg acc cgg gtg tgt agg acg ggg agg tca cga tgg cgc gac gtc tgc      441
 Ala Thr Arg Val Cys Arg Thr Gly Arg Ser Arg Trp Arg Asp Val Cys
 115                 120                 125                 130

 aga aat ttc atg agg agg tat cag tct aga gtt acc cag ggc ctc gtg      489
 Arg Asn Phe Met Arg Arg Tyr Gln Ser Arg Val Thr Gln Gly Leu Val
                 135                 140                 145

 gcc gga gaa act gcc cag cag atc tgt gag gac ctc agg ttg tgt ata      537
 Ala Gly Glu Thr Ala Gln Gln Ile Cys Glu Asp Leu Arg Leu Cys Ile
             150                 155                 160

 cct tct aca ggt ccc ctc tga gc cctctcacct tgtcctgtgg aagaagcaca      590
 Pro Ser Thr Gly Pro Leu 
         165

 ggctcctgtc ctcagatccc gggaacctca gcaacctctg ccggctcctc gcttcctcga    650

 tccagaatcc actctccagt ctccctcccc tgactccctc tgctgtcctc ccctctcacg    710

 agaataaagt gtcaagcaag aaaaaaaaaa aaa                                 743




      <210> 565
      <211> 873
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (30)..(623)

      <400> 565
 ccacacaaga agggtaggag agaaaagcc  atg gcc gac aag gtc ctg aag gag      53
                                  Met Ala Asp Lys Val Leu Lys Glu
                                    1               5

 aag aga aag ctg ttt atc cat tcc atg ggt gaa ggt aca ata aat ggc      101
 Lys Arg Lys Leu Phe Ile His Ser Met Gly Glu Gly Thr Ile Asn Gly
      10                  15                  20

 tta ctg gat gaa tta tta cag aca agg gtg ctg aac cag gaa gag atg      149
 Leu Leu Asp Glu Leu Leu Gln Thr Arg Val Leu Asn Gln Glu Glu Met
  25                  30                  35                  40

 gag aaa gta aaa cgt gaa aat gct aca gtt atg gat aag acc cga gct      197
 Glu Lys Val Lys Arg Glu Asn Ala Thr Val Met Asp Lys Thr Arg Ala
                  45                  50                  55

 ttg att gac tcc gtt att ccg aaa ggg gca cag gca tgc caa att tgc      245
 Leu Ile Asp Ser Val Ile Pro Lys Gly Ala Gln Ala Cys Gln Ile Cys
              60                  65                  70

 atc aca tac att tgt gaa gaa gac agt tac ctg gca gag acg ctg gga      293
 Ile Thr Tyr Ile Cys Glu Glu Asp Ser Tyr Leu Ala Glu Thr Leu Gly
          75                  80                  85

 ctc tca gca gct ctt cag gca gtg cag gac aac cca gct atg ccc aca      341
 Leu Ser Ala Ala Leu Gln Ala Val Gln Asp Asn Pro Ala Met Pro Thr
      90                  95                 100

 tgc tca agc cca gaa ggc aga atc aag ctt tgc ttt cta gaa gac gct      389
 Cys Ser Ser Pro Glu Gly Arg Ile Lys Leu Cys Phe Leu Glu Asp Ala
 105                 110                 115                 120

 caa agg ata tgg aaa caa aag ttg cag agg tgc cat gtt cag aat aca      437
 Gln Arg Ile Trp Lys Gln Lys Leu Gln Arg Cys His Val Gln Asn Thr
                 125                 130                 135

 ata ata aag tgg agt gaa aga tat act tca ggc agt ttt gaa atg cag      485
 Ile Ile Lys Trp Ser Glu Arg Tyr Thr Ser Gly Ser Phe Glu Met Gln
             140                 145                 150

 tgg ctt ttt ctt aga acc aat ttt att gag cgg ttc tgg agg aac ata      533
 Trp Leu Phe Leu Arg Thr Asn Phe Ile Glu Arg Phe Trp Arg Asn Ile
         155                 160                 165

 ctt ctg ctc ccc ttg cat aaa gga tct cta tat cct aga atc cca ggt      581
 Leu Leu Leu Pro Leu His Lys Gly Ser Leu Tyr Pro Arg Ile Pro Gly
     170                 175                 180

 tta ggt aaa gag ttg caa act gga act cat aaa tta tca tag tcttcac      630
 Leu Gly Lys Glu Leu Gln Thr Gly Thr His Lys Leu Ser 
 185                 190                 195

 ccagtctgtc tcttagaatt tatttcccac tgacacaaac aagccatttt gtctgcttgt    690

 ataacccaga ttttccagtg tagtgcccag ttggaaaaaa gcacatccca ttgagcaagt    750

 attgaagtgg actcttgctt ctcacccaat tctccaactt gtgtttacca agaattggag    810

 tcagtttttt acctgttgtt cctattcata aaatgaaatt aatgtttatt taaaaaaaaa    870

 aaa                                                                  873




      <210> 566
      <211> 778
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (159)..(605)

      <400> 566
 acacggccgg aattcccgtg tcgacgattt cgtcaaaatc cagcaggagg ccaccaggag     60

 ctgaccccca tgcagagagg aagcaccagc actctgggtg agtgaggcca aggtcacagt    120

 cagtccccag gagagccggc agccggccca gggcccag    atg ggc ctc tgg ctc     173
                                              Met Gly Leu Trp Leu
                                                1               5

 aag ccc agc aga ggc tgt gtc cac cgg gcc ttg agg tct gca cgg gag      221
 Lys Pro Ser Arg Gly Cys Val His Arg Ala Leu Arg Ser Ala Arg Glu
                  10                  15                  20

 gcc cgt ccc tca ccc ccc agg gca aga aca agc cca cgc ctc agc cct      269
 Ala Arg Pro Ser Pro Pro Arg Ala Arg Thr Ser Pro Arg Leu Ser Pro
              25                  30                  35

 gtt ggc ggt gga gca gga aca tcc ctg cag tgc ttt aag ggc aca ctt      317
 Val Gly Gly Gly Ala Gly Thr Ser Leu Gln Cys Phe Lys Gly Thr Leu
          40                  45                  50

 gtt att ttt tgt tca gct cgt ggc agc agg tgt gcc ttg gaa tct aga      365
 Val Ile Phe Cys Ser Ala Arg Gly Ser Arg Cys Ala Leu Glu Ser Arg
      55                  60                  65

 tgt ttt ttg tat ccc caa ggg aac cca ggc tca ggt ttt agg cta gaa      413
 Cys Phe Leu Tyr Pro Gln Gly Asn Pro Gly Ser Gly Phe Arg Leu Glu
  70                  75                  80                  85

 aac aag aca act gca gat ggt aat tat ccc cca gga tca cta gtc aaa      461
 Asn Lys Thr Thr Ala Asp Gly Asn Tyr Pro Pro Gly Ser Leu Val Lys
                  90                  95                 100

 ggc tgc ttt tgg tca aga atc tca acc tgc gtg cct gtc tgt gtg gca      509
 Gly Cys Phe Trp Ser Arg Ile Ser Thr Cys Val Pro Val Cys Val Ala
             105                 110                 115

 cac cct cct cag gaa cag cct cgc aac ttt ccc tgg aac ctc ccc ttc      557
 His Pro Pro Gln Glu Gln Pro Arg Asn Phe Pro Trp Asn Leu Pro Phe
         120                 125                 130

 ccc act aca cct ggt cct ggc gag gat att att cac atc agt gaa taa      605
 Pro Thr Thr Pro Gly Pro Gly Glu Asp Ile Ile His Ile Ser Glu 
     135                 140                 145

 aatgctaatt ttagtggggg gctgacaaac agttctcaca caccagtgtg caccaacatc    665

 ccctggagag tgtgttggag cacagactcc tgtcggcccg gcggctcacc cctgtaaccc    725

 cagccctgtg ataggccaag gcgggagggt aacgagaatg catctctcca aaa           778




      <210> 567
      <211> 1701
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (85)..(1398)

      <400> 567
 gtgacattca caccacagcc tttgatggaa gctcaaaagg aataagactg ggccagtgcc     60

 attcgcgtcg cagctctgga ctgc   atg gaa gag aag aac cag gcc gtg tgc     111
                              Met Glu Glu Lys Asn Gln Ala Val Cys
                                1               5

 cat gac tac gac atc cac ttc tac ccc acc ttc cgg tat ttt aaa gca      159
 His Asp Tyr Asp Ile His Phe Tyr Pro Thr Phe Arg Tyr Phe Lys Ala
  10                  15                  20                  25

 ttt aca aag gag ttt aca act gga gaa aat ttt aaa gga cct gac cga      207
 Phe Thr Lys Glu Phe Thr Thr Gly Glu Asn Phe Lys Gly Pro Asp Arg
                  30                  35                  40

 gag ctg cga aca gtc aga cag acg atg att gac ttc ctg cag aac cac      255
 Glu Leu Arg Thr Val Arg Gln Thr Met Ile Asp Phe Leu Gln Asn His
              45                  50                  55

 acg gaa gga agc cgg ccc cct gcc tgc ccg cgc cta gac ccc att cag      303
 Thr Glu Gly Ser Arg Pro Pro Ala Cys Pro Arg Leu Asp Pro Ile Gln
          60                  65                  70

 ccc agt gat gtt ctt tcc ctt ctt gac aac cgt ggc agc cat tac gtg      351
 Pro Ser Asp Val Leu Ser Leu Leu Asp Asn Arg Gly Ser His Tyr Val
      75                  80                  85

 gct att gtc ttt gaa agc aac agc tcc tac ctt gga cgg gag gtg atc      399
 Ala Ile Val Phe Glu Ser Asn Ser Ser Tyr Leu Gly Arg Glu Val Ile
  90                  95                 100                 105

 tta gac ctg atc ccg tat gaa agc atc gtg gtg acc cga gca ctg gac      447
 Leu Asp Leu Ile Pro Tyr Glu Ser Ile Val Val Thr Arg Ala Leu Asp
                 110                 115                 120

 ggg gac aaa gca ttt ctg gag aaa ctt ggt gtt tct tca gtc cct tcg      495
 Gly Asp Lys Ala Phe Leu Glu Lys Leu Gly Val Ser Ser Val Pro Ser
             125                 130                 135

 tgt tac ctg atc tac cca aat ggg tcg cat gga ttg att aac gtc gtg      543
 Cys Tyr Leu Ile Tyr Pro Asn Gly Ser His Gly Leu Ile Asn Val Val
         140                 145                 150

 aag cct ctg cgg gcc ttc ttt tcg tct tat ttg aag tca ttg ccg gat      591
 Lys Pro Leu Arg Ala Phe Phe Ser Ser Tyr Leu Lys Ser Leu Pro Asp
     155                 160                 165

 gtg agg aaa aaa tcg ctt ccc ttg cct gaa aag cca cac aaa gaa gaa      639
 Val Arg Lys Lys Ser Leu Pro Leu Pro Glu Lys Pro His Lys Glu Glu
 170                 175                 180                 185

 aat tca gaa atc gtg gtt tgg aga gaa ttt gac aag tcg aag ctg tac      687
 Asn Ser Glu Ile Val Val Trp Arg Glu Phe Asp Lys Ser Lys Leu Tyr
                 190                 195                 200

 acg gtg gac ctg gag tca ggg cta cac tac ctc ctg cgg gtg gag ctg      735
 Thr Val Asp Leu Glu Ser Gly Leu His Tyr Leu Leu Arg Val Glu Leu
             205                 210                 215

 gca gcc cac aag tcc ctg gcc gga gca gag ctg aag acg ctc aag gac      783
 Ala Ala His Lys Ser Leu Ala Gly Ala Glu Leu Lys Thr Leu Lys Asp
         220                 225                 230

 ttt gtg act gtc ttg gcc aag ctg ttc cct gga cgg ccg cca gtc aag      831
 Phe Val Thr Val Leu Ala Lys Leu Phe Pro Gly Arg Pro Pro Val Lys
     235                 240                 245

 aag ctg ttg gag atg ctg cag gag tgg ctg gcc agc ctt ccc ctg gac      879
 Lys Leu Leu Glu Met Leu Gln Glu Trp Leu Ala Ser Leu Pro Leu Asp
 250                 255                 260                 265

 agg atc ccc tac aac gcc gtg ctt gac ctg gtc aac aac aag atg cgg      927
 Arg Ile Pro Tyr Asn Ala Val Leu Asp Leu Val Asn Asn Lys Met Arg
                 270                 275                 280

 att tct gga ata ttc ctt act aat cac ata aag tgg gtt gga tgt caa      975
 Ile Ser Gly Ile Phe Leu Thr Asn His Ile Lys Trp Val Gly Cys Gln
             285                 290                 295

 gga agc cga tct gag ttg agg ggt tac ccg tgt tct ctc tgg aaa ctg     1023
 Gly Ser Arg Ser Glu Leu Arg Gly Tyr Pro Cys Ser Leu Trp Lys Leu
         300                 305                 310

 ttc cac act ttg act gtt gaa gcc tcg acc cac cca gat gca ctg gtt     1071
 Phe His Thr Leu Thr Val Glu Ala Ser Thr His Pro Asp Ala Leu Val
     315                 320                 325

 ggc aca ggc ttt gaa gac gac ccc cag gct gtg ctg cag aca atg agg     1119
 Gly Thr Gly Phe Glu Asp Asp Pro Gln Ala Val Leu Gln Thr Met Arg
 330                 335                 340                 345

 agg tac gtt cac acc ttc ttt ggg tgt aag gaa tgt ggt gag cac ttt     1167
 Arg Tyr Val His Thr Phe Phe Gly Cys Lys Glu Cys Gly Glu His Phe
                 350                 355                 360

 gag gaa atg gct aaa gaa tcc atg gac tcg gtg aaa acc cca gac caa     1215
 Glu Glu Met Ala Lys Glu Ser Met Asp Ser Val Lys Thr Pro Asp Gln
             365                 370                 375

 gcc atc ctc tgg ctg tgg aag aag cat aat atg gtg aac ggc cgc ctg     1263
 Ala Ile Leu Trp Leu Trp Lys Lys His Asn Met Val Asn Gly Arg Leu
         380                 385                 390

 gca ggt gag aag ccc ctg ggc atg ggg ggc tca gca cgg gcg gag gga     1311
 Ala Gly Glu Lys Pro Leu Gly Met Gly Gly Ser Ala Arg Ala Glu Gly
     395                 400                 405

 ggc cct ggt cct ggg aca gca agg acg gca cgg ctg ccg tgg ggc ttg     1359
 Gly Pro Gly Pro Gly Thr Ala Arg Thr Ala Arg Leu Pro Trp Gly Leu
 410                 415                 420                 425

 tcc ctg agc ttt gcg gcc tcg tgc cac cca ctg tgc tga cgggatcagg      1408
 Ser Leu Ser Phe Ala Ala Ser Cys His Pro Leu Cys 
                 430                 435

 acttgggtgg ctgagagctg ccagagctgc agcctttccc aggctgcttc tgtccccggc   1468

 tttctagatg cttctctcac tccgggggct cttcgacccc gtggaaatgg gtgtggctct   1528

 ttcttccccc atcggtaccc actggtagcc cgttagactc tgaagatgtt tttgactctg   1588

 gaaagcttgg aacgtaatta atttttgatg aggaatttta gtagtatgga aatctgttgt   1648

 ccaaacgtaa accaaacctc tcaaagtgct ttgttttgtt aaaaaaaaaa aaa          1701


      <210> 568
      <211> 333
      <212> PRT
      <213> Homo sapiens


      <400> 568
 Met Ala Ser Ala Thr Ala Pro Ala Ala Ala Val Pro Thr Leu Ala Ser
   1               5                  10                  15    
 Pro Leu Glu Gln Leu Arg His Leu Ala Glu Glu Leu Arg Leu Leu Leu
              20                  25                  30        
 Pro Arg Val Arg Val Gly Glu Ala Gln Glu Thr Thr Glu Glu Phe Asn
          35                  40                  45            
 Arg Glu Met Phe Trp Arg Arg Leu Asn Glu Ala Ala Val Thr Val Ser
      50                  55                  60                
 Arg Glu Ala Thr Thr Leu Thr Ile Val Phe Ser Gln Leu Pro Leu Pro
  65                  70                  75                  80
 Ser Pro Gln Glu Thr Gln Lys Phe Cys Glu Gln Val His Ala Ala Ile
                  85                  90                  95    
 Lys Ala Phe Ile Ala Val Tyr Tyr Leu Leu Pro Lys Asp Gln Gly Ile
             100                 105                 110        
 Thr Leu Arg Lys Leu Val Arg Gly Ala Thr Leu Asp Ile Val Asp Gly
         115                 120                 125            
 Met Ala Gln Leu Met Glu Val Leu Ser Val Thr Pro Thr Gln Ser Pro
     130                 135                 140                
 Glu Asn Asn Asp Leu Ile Ser Tyr Asn Ser Val Trp Val Ala Cys Gln
 145                 150                 155                 160
 Gln Met Pro Gln Ile Pro Arg Asp Asn Lys Ala Ala Ala Leu Leu Met
                 165                 170                 175    
 Leu Thr Lys Asn Val Asp Phe Val Lys Asp Ala His Glu Glu Met Glu
             180                 185                 190        
 Gln Ala Val Glu Glu Cys Asp Pro Tyr Ser Gly Leu Leu Asn Asp Thr
         195                 200                 205            
 Glu Glu Asn Asn Ser Asp Asn His Asn His Glu Asp Asp Val Leu Gly
     210                 215                 220                
 Phe Pro Ser Asn Gln Asp Leu Tyr Trp Ser Glu Asp Asp Gln Glu Leu
 225                 230                 235                 240
 Ile Ile Pro Cys Leu Ala Leu Val Arg Ala Ser Lys Ala Cys Leu Lys
                 245                 250                 255    
 Lys Ile Arg Met Leu Val Ala Glu Asn Gly Lys Lys Asp Gln Val Ala
             260                 265                 270        
 Gln Leu Asp Asp Ile Gly Asp Ile Ser Asp Glu Ile Ser Pro Ser Val
         275                 280                 285            
 Asp Asp Leu Ala Leu Ser Ile Tyr Pro Pro Met Cys His Leu Thr Val
     290                 295                 300                
 Arg Ile Asn Val Ser Thr Gly Phe Glu Gly Ile Ala Thr Glu Gln Met
 305                 310                 315                 320
 Gly Arg Ile Ser Leu Ile Thr Ser Ile Ser Cys Lys Leu
                 325                 330            



      <210> 569
      <211> 236
      <212> PRT
      <213> Homo sapiens


      <400> 569
 Met Thr Glu Trp Glu Thr Ala Ala Pro Ala Val Ala Glu Thr Pro Asp
   1               5                  10                  15    
 Ile Lys Leu Phe Gly Lys Trp Ser Thr Asp Asp Val Gln Ile Asn Asp
              20                  25                  30        
 Ile Ser Leu Gln Asp Tyr Ile Ala Val Lys Glu Lys Tyr Ala Lys Tyr
          35                  40                  45            
 Leu Pro His Ser Ala Gly Arg Tyr Ala Ala Lys Arg Phe Arg Lys Ala
      50                  55                  60                
 Gln Cys Pro Ile Val Glu Arg Leu Thr Asn Ser Met Met Met His Gly
  65                  70                  75                  80
 Arg Asn Asn Gly Lys Lys Leu Met Thr Val Arg Ile Val Lys His Ala
                  85                  90                  95    
 Phe Glu Ile Ile His Leu Leu Thr Gly Glu Asn Pro Leu Gln Val Leu
             100                 105                 110        
 Val Asn Ala Ile Ile Asn Ser Gly Pro Arg Glu Asp Ser Thr Arg Ile
         115                 120                 125            
 Gly Cys Ala Gly Thr Val Arg Arg Gln Ala Val Asp Val Ser Pro Leu
     130                 135                 140                
 Arg Arg Val Asn Gln Ala Ile Trp Leu Leu Cys Thr Gly Ala Arg Glu
 145                 150                 155                 160
 Ala Ala Phe Arg Asn Ile Lys Thr Ile Asp Glu Cys Leu Ala Glu Glu
                 165                 170                 175    
 Leu Ile Asn Ala Ala Lys Gly Ser Ser Asn Ser Tyr Ala Ile Lys Lys
             180                 185                 190        
 Lys Asp Val Trp Pro Ser Trp Ser Met Trp Pro Ser Pro Thr Ala Asp
         195                 200                 205            
 Phe Pro Ser Cys Cys Pro Ile Asn Leu Ser Ala Leu Gln Gly Ser Pro
     210                 215                 220                
 Thr Lys Lys Ser Lys Lys Ile Thr Thr Lys Leu Leu
 225                 230                 235    



      <210> 570
      <211> 1243
      <212> PRT
      <213> Homo sapiens


      <400> 570
 Met Trp Pro Glu Leu Thr Gly Ser Pro Val Arg Gly Cys Ser Gln Val
   1               5                  10                  15    
 Val Gln Arg Ser Trp Ser Met Ala Ala Ala Thr Val Gly Arg Asp Thr
              20                  25                  30        
 Leu Pro Glu His Trp Ser Tyr Gly Val Cys Arg Asp Gly Arg Val Phe
          35                  40                  45            
 Phe Ile Asn Asp Gln Leu Arg Cys Thr Thr Trp Leu His Pro Arg Thr
      50                  55                  60                
 Gly Glu Pro Val Asn Ser Gly His Met Ile Arg Ser Asp Leu Pro Arg
  65                  70                  75                  80
 Gly Trp Glu Glu Gly Phe Thr Glu Glu Gly Ala Ser Tyr Phe Ile Asp
                  85                  90                  95    
 His Asn Gln Gln Thr Thr Ala Phe Arg His Pro Val Thr Gly Gln Phe
             100                 105                 110        
 Ser Pro Glu Asn Ser Glu Phe Ile Leu Gln Glu Glu Pro Asn Pro His
         115                 120                 125            
 Met Ser Lys Gln Asp Arg Asn Gln Arg Pro Ser Ser Met Val Ser Glu
     130                 135                 140                
 Thr Ser Thr Ala Gly Thr Ala Ser Thr Leu Glu Ala Lys Pro Gly Pro
 145                 150                 155                 160
 Lys Ile Ile Lys Ser Ser Ser Lys Val His Ser Phe Gly Lys Arg Asp
                 165                 170                 175    
 Gln Ala Ile Arg Arg Asn Pro Asn Val Pro Val Val Val Arg Gly Trp
             180                 185                 190        
 Leu His Lys Gln Asp Ser Ser Gly Met Arg Leu Trp Lys Arg Arg Trp
         195                 200                 205            
 Phe Val Leu Ala Asp Tyr Cys Leu Phe Tyr Tyr Lys Asp Ser Arg Glu
     210                 215                 220                
 Glu Ala Val Leu Gly Ser Ile Pro Leu Pro Ser Tyr Val Ile Ser Pro
 225                 230                 235                 240
 Val Ala Pro Glu Asp Arg Ile Ser Arg Lys Tyr Ser Phe Lys Ala Val
                 245                 250                 255    
 His Thr Gly Met Arg Ala Leu Ile Tyr Asn Ser Ser Thr Ala Gly Ser
             260                 265                 270        
 Gln Ala Glu Gln Ser Gly Met Arg Thr Tyr Tyr Phe Ser Ala Asp Thr
         275                 280                 285            
 Gln Glu Asp Met Asn Ala Trp Val Arg Ala Met Asn Gln Ala Ala Gln
     290                 295                 300                
 Val Leu Ser Arg Ser Ser Leu Lys Arg Asp Met Glu Lys Val Glu Arg
 305                 310                 315                 320
 Gln Ala Val Pro Gln Ala Asn His Thr Glu Ser Cys His Glu Cys Gly
                 325                 330                 335    
 Arg Val Gly Pro Gly His Thr Arg Asp Cys Pro His Arg Gly His Asp
             340                 345                 350        
 Asp Ile Val Asn Phe Glu Arg Gln Glu Gln Glu Gly Glu Gln Tyr Arg
         355                 360                 365            
 Ser Gln Arg Asp Pro Leu Glu Gly Lys Arg Asp Arg Ser Lys Ala Arg
     370                 375                 380                
 Ser Pro Tyr Ser Pro Ala Glu Glu Asp Ala Leu Phe Met Asp Leu Pro
 385                 390                 395                 400
 Thr Gly Pro Arg Gly Gln Gln Ala Gln Pro Gln Arg Ala Glu Lys Asn
                 405                 410                 415    
 Gly Met Leu Pro Ala Ser Tyr Gly Pro Gly Glu Gln Asn Gly Thr Gly
             420                 425                 430        
 Gly Tyr Gln Arg Ala Phe Pro Pro Arg Thr Asn Pro Glu Lys His Ser
         435                 440                 445            
 Gln Arg Lys Ser Asn Leu Ala Gln Val Glu His Trp Ala Arg Ala Gln
     450                 455                 460                
 Lys Gly Asp Ser Arg Ser Leu Pro Leu Asp Gln Thr Leu Pro Arg Gln
 465                 470                 475                 480
 Gly Pro Gly Gln Ser Leu Ser Phe Pro Glu Asn Tyr Gln Thr Leu Pro
                 485                 490                 495    
 Lys Ser Thr Arg His Pro Ser Gly Gly Ser Ser Pro Pro Pro Arg Asn
             500                 505                 510        
 Leu Pro Ser Asp Tyr Lys Tyr Ala Gln Asp Arg Ala Ser His Leu Lys
         515                 520                 525            
 Met Ser Ser Glu Glu Arg Arg Ala His Arg Asp Gly Thr Val Trp Gln
     530                 535                 540                
 Leu Tyr Glu Trp Gln Gln Arg Gln Gln Phe Arg His Gly Ser Pro Thr
 545                 550                 555                 560
 Ala Pro Ile Cys Leu Gly Ser Pro Glu Phe Thr Asp Gln Gly Arg Ser
                 565                 570                 575    
 Arg Ser Met Leu Glu Val Pro Arg Ser Ile Ser Val Pro Pro Ser Pro
             580                 585                 590        
 Ser Asp Ile Pro Pro Pro Gly Pro Pro Arg Val Phe Pro Pro Arg Arg
         595                 600                 605            
 Pro His Thr Pro Ala Glu Arg Val Thr Val Lys Pro Pro Asp Gln Arg
     610                 615                 620                
 Arg Ser Val Asp Ile Ser Leu Gly Asp Ser Pro Arg Arg Ala Arg Gly
 625                 630                 635                 640
 His Ala Val Lys Asn Ser Ser His Val Asp Arg Arg Ser Met Pro Ser
                 645                 650                 655    
 Met Gly Tyr Met Thr His Thr Val Ser Ala Pro Ser Leu His Gly Lys
             660                 665                 670        
 Ser Ala Asp Asp Thr Tyr Leu Gln Leu Lys Lys Asp Leu Glu Tyr Leu
         675                 680                 685            
 Asp Leu Lys Met Thr Gly Arg Asp Leu Leu Lys Asp Arg Ser Leu Lys
     690                 695                 700                
 Pro Val Lys Ile Ala Glu Ser Asp Thr Asp Val Lys Leu Ser Ile Phe
 705                 710                 715                 720
 Cys Glu Gln Asp Arg Val Leu Gln Asp Leu Glu Asp Lys Ile Arg Ala
                 725                 730                 735    
 Leu Lys Glu Asn Lys Asp Gln Leu Glu Ser Val Leu Glu Val Leu His
             740                 745                 750        
 Arg Gln Met Glu Gln Tyr Arg Asp Gln Pro Gln His Leu Glu Lys Ile
         755                 760                 765            
 Ala Tyr Gln Gln Lys Leu Leu Gln Glu Asp Leu Val His Ile Arg Ala
     770                 775                 780                
 Glu Leu Ser Arg Glu Ser Thr Glu Met Glu Asn Ala Trp Asn Glu Tyr
 785                 790                 795                 800
 Pro Lys Leu Glu Asn Asp Val Glu Gln Leu Lys Gln Thr Leu Gln Glu
                 805                 810                 815    
 Gln His Arg Arg Ala Phe Phe Phe Gln Glu Lys Ser Gln Ile Gln Lys
             820                 825                 830        
 Asp Leu Trp Arg Ile Glu Asp Val Thr Ala Gly Leu Ser Ala Asn Lys
         835                 840                 845            
 Glu Asn Phe Arg Ile Leu Val Glu Ser Val Lys Asn Pro Gly Glu Met
     850                 855                 860                
 Phe Ile Phe Leu Asp Val Gly Asp Leu Ile Gly Gly Arg Val Val Gly
 865                 870                 875                 880
 Gly Trp Lys Ala Gly Asn Gln Glu Asp Glu Ala Pro Pro Arg Pro Pro
                 885                 890                 895    
 Leu Pro Glu Leu Tyr Ser Pro Glu Asp Gln Pro Pro Ala Val Pro Pro
             900                 905                 910        
 Leu Pro Arg Glu Ala Thr Ile Ile Arg His Thr Ser Val Arg Gly Leu
         915                 920                 925            
 Lys Arg Gln Ser Asp Glu Arg Lys Arg Asp Arg Glu Leu Gly Gln Cys
     930                 935                 940                
 Val Asn Gly Asp Ser Arg Val Glu Leu Arg Ser Tyr Val Ser Glu Pro
 945                 950                 955                 960
 Glu Leu Ala Thr Leu Ser Gly Asp Met Ala Gln Pro Ser Leu Gly Leu
                 965                 970                 975    
 Val Gly Pro Glu Ser Arg Tyr Gln Thr Leu Pro Gly Arg Gly Leu Ser
             980                 985                 990        
 Gly Ser Thr Ser Arg Leu Gln Gln Ser Ser Thr Ile Ala Pro Tyr Val
         995                1000                1005            
 Thr Leu Arg Arg Gly Leu Asn Ala Glu Ser Ser Lys Ala Thr Phe Pro
    1010                1015                1020                
 Arg Pro Lys Ser Ala Leu Glu Arg Leu Tyr Ser Gly Asp His Gln Arg
1025                1030                1035                1040
 Gly Lys Met Ser Ala Glu Glu Gln Leu Glu Arg Met Lys Arg His Gln
                1045                1050                1055    
 Lys Ala Leu Val Arg Glu Arg Lys Arg Thr Leu Gly Gln Gly Glu Arg
            1060                1065                1070        
 Thr Gly Leu Pro Ser Ser Arg Tyr Leu Ser Arg Pro Leu Pro Gly Asp
        1075                1080                1085            
 Leu Gly Ser Trp Lys Arg Glu Gln Asp Phe Asp Leu Gln Leu Leu Glu
    1090                1095                1100                
 Arg Val Val Gln Gly Glu Lys Lys Asp Lys Glu Glu Asn Gly Trp Leu
1105                1110                1115                1120
 Lys Val Gln Ala Met Pro Val Thr Glu Leu Asp Leu Glu Pro Gln His
                1125                1130                1135    
 Tyr Asp Leu Asp Ile Ser Arg Glu Leu Ser Lys Pro Glu Lys Val Ser
            1140                1145                1150        
 Ile Pro Glu Arg Tyr Val Glu Leu Asp Pro Glu Glu Pro Pro Ser Leu
        1155                1160                1165            
 Glu Glu Leu Gln Ala Arg Tyr Arg Lys Ala Glu Lys Ile Arg Asn Ile
    1170                1175                1180                
 Leu Ala Arg Ser Ser Met Cys Asn Leu Gln Pro Thr Ser Gly Gln Asp
1185                1190                1195                1200
 Gln Asn Ser Val Ala Asp Leu Asp Leu Gln Leu Gln Glu Gln Glu Arg
                1205                1210                1215    
 Ile Ile Asn Ile Ser Tyr Ala Leu Ala Ser Glu Ala Ser Gln Arg Ser
            1220                1225                1230        
 Lys Gln Val Ala Ala Gln Ala Val Thr Asp Pro
        1235                1240            



      <210> 571
      <211> 239
      <212> PRT
      <213> Homo sapiens


      <400> 571
 Met Val Phe Leu Val Ser Asp Pro Ser Gly Arg Met Val Lys Ser Ser
   1               5                  10                  15    
 Leu Gln Arg Ile Leu Asn Ser His Cys Phe Ala Arg Glu Lys Glu Gly
              20                  25                  30        
 Asp Lys Pro Ser Ala Thr Ile His Ala Ser Arg Thr Met Pro Leu Leu
          35                  40                  45            
 Ser Leu His Ser Arg Gly Ala Ala Ala Val Arg Val Pro Gly Ser Pro
      50                  55                  60                
 Ser Thr Ala Val Val Thr Arg Val Arg Gly Leu Gly Gly Ala Pro Asp
  65                  70                  75                  80
 Ala Pro Arg Pro Pro Leu Lys Ile Pro Gly Gly Arg Gly Asn Ser Gln
                  85                  90                  95    
 Arg Asp His Asn Leu Ser Ala Asn Leu Phe Tyr Ser Asp Asp Arg Leu
             100                 105                 110        
 Asn Val Thr Glu Glu Leu Thr Ser Asn Asp Lys Thr Arg Ile Leu Asn
         115                 120                 125            
 Val Gln Ser Arg Leu Thr Asp Ala Lys Arg Ile Asn Trp Arg Thr Val
     130                 135                 140                
 Leu Ser Gly Gly Ser Leu Tyr Ile Glu Ile Pro Gly Gly Ala Leu Pro
 145                 150                 155                 160
 Glu Gly Ser Lys Asp Ser Phe Ala Val Leu Leu Glu Phe Ala Glu Glu
                 165                 170                 175    
 Gln Leu Arg Ala Asp His Val Phe Ile Cys Phe His Lys Asn Arg Glu
             180                 185                 190        
 Asp Arg Ala Ala Leu Leu Arg Thr Phe Ser Phe Leu Gly Phe Glu Ile
         195                 200                 205            
 Val Arg Pro Gly His Pro Leu Val Pro Lys Arg Pro Asp Ala Cys Phe
     210                 215                 220                
 Met Ala Tyr Thr Phe Glu Lys Glu Ser Ser Gly Lys Glu Glu Glu
 225                 230                 235                



      <210> 572
      <211> 364
      <212> PRT
      <213> Homo sapiens


      <400> 572
 Met Glu Ala Val Ala Gly Ser Pro Leu Arg Ala Ala Gly Arg Gln Asp
   1               5                  10                  15    
 Pro Ala Thr Ser Arg Ile Pro Arg Ala Ala Thr Arg Ser Arg His Arg
              20                  25                  30        
 Ala Ala Thr Gly Arg Gly Ala Gly Ala Ala Met Ala Thr Gly Gly Gln
          35                  40                  45            
 Gln Lys Glu Asn Thr Leu Leu His Ala Leu Arg Arg Arg Arg Val Glu
      50                  55                  60                
 Ala Gln Leu Gly Ala Ile Phe Thr Cys Pro Leu Glu Val Ile Lys Thr
  65                  70                  75                  80
 Arg Leu Gln Ser Ser Arg Leu Ala Leu Arg Thr Val Tyr Tyr Pro Gln
                  85                  90                  95    
 Val His Leu Gly Thr Ile Ser Gly Ala Gly Met Val Arg Pro Thr Ser
             100                 105                 110        
 Val Thr Pro Gly Leu Phe Gln Val Leu Lys Ser Ile Leu Glu Lys Glu
         115                 120                 125            
 Gly Pro Lys Ser Leu Phe Arg Gly Leu Gly Pro Asn Leu Val Gly Val
     130                 135                 140                
 Ala Pro Ser Arg Ala Val Tyr Phe Ala Cys Tyr Ser Lys Ala Lys Glu
 145                 150                 155                 160
 Gln Phe Asn Gly Ile Phe Val Pro Asn Ser Asn Ile Val His Ile Phe
                 165                 170                 175    
 Ser Ala Gly Ser Ala Ala Phe Ile Thr Asn Ser Leu Met Asn Pro Ile
             180                 185                 190        
 Trp Met Val Lys Thr Arg Met Gln Leu Glu Gln Lys Val Arg Gly Ser
         195                 200                 205            
 Lys Gln Met Asn Thr Leu Gln Cys Ala Arg Tyr Val Tyr Gln Thr Glu
     210                 215                 220                
 Gly Ile Arg Gly Phe Tyr Arg Gly Leu Thr Ala Ser Tyr Ala Gly Ile
 225                 230                 235                 240
 Ser Glu Thr Ile Ile Cys Phe Ala Ile Tyr Glu Ser Leu Lys Lys Tyr
                 245                 250                 255    
 Leu Lys Glu Ala Pro Leu Ala Ser Ser Ala Asn Gly Thr Glu Lys Asn
             260                 265                 270        
 Ser Thr Ser Phe Phe Gly Leu Met Ala Ala Ala Ala Leu Ser Lys Gly
         275                 280                 285            
 Cys Ala Ser Cys Ile Ala Tyr Pro His Glu Val Ile Arg Thr Arg Leu
     290                 295                 300                
 Arg Glu Glu Gly Thr Lys Tyr Lys Ser Phe Val Gln Thr Ala Arg Leu
 305                 310                 315                 320
 Val Phe Arg Glu Glu Gly Tyr Leu Ala Phe Tyr Arg Gly Leu Phe Ala
                 325                 330                 335    
 Gln Leu Ile Arg Gln Ile Pro Asn Thr Ala Ile Val Leu Ser Thr Tyr
             340                 345                 350        
 Glu Leu Ile Val Tyr Leu Leu Glu Asp Arg Thr Gln
         355                 360                



      <210> 573
      <211> 689
      <212> PRT
      <213> Homo sapiens


      <400> 573
 Met Thr Ser Gln Pro Leu Arg Leu Ala Glu Glu Tyr Gly Pro Ser Pro
   1               5                  10                  15    
 Gly Glu Ser Glu Leu Ala Val Asn Pro Phe Asp Gly Leu Pro Phe Ser
              20                  25                  30        
 Ser Arg Tyr Tyr Glu Leu Leu Lys Gln Arg Gln Ala Leu Pro Ile Trp
          35                  40                  45            
 Ala Ala Arg Phe Thr Phe Leu Glu Gln Leu Glu Ser Asn Pro Thr Gly
      50                  55                  60                
 Val Val Leu Val Ser Gly Glu Pro Gly Ser Gly Lys Ser Thr Gln Ile
  65                  70                  75                  80
 Pro Gln Trp Cys Ala Glu Phe Ala Leu Ala Arg Gly Phe Gln Lys Gly
                  85                  90                  95    
 Gln Val Thr Val Thr Gln Pro Tyr Pro Leu Ala Ala Arg Ser Leu Ala
             100                 105                 110        
 Leu Arg Val Ala Asp Glu Met Asp Leu Thr Leu Gly His Glu Val Gly
         115                 120                 125            
 Tyr Ser Ile Pro Gln Glu Asp Cys Thr Gly Pro Asn Thr Leu Leu Arg
     130                 135                 140                
 Phe Cys Trp Asp Arg Leu Leu Leu Gln Glu Val Ala Ser Thr Arg Gly
 145                 150                 155                 160
 Thr Gly Ala Trp Gly Val Leu Val Leu Asp Glu Ala Gln Glu Arg Ser
                 165                 170                 175    
 Val Ala Ser Asp Ser Leu Gln Gly Leu Leu Gln Asp Ala Arg Leu Glu
             180                 185                 190        
 Lys Leu Pro Gly Asp Leu Arg Val Val Val Val Thr Asp Pro Ala Leu
         195                 200                 205            
 Glu Pro Lys Leu Arg Ala Phe Trp Gly Asn Pro Pro Ile Val His Ile
     210                 215                 220                
 Pro Arg Glu Pro Gly Glu Arg Pro Ser Pro Ile Tyr Trp Asp Thr Ile
 225                 230                 235                 240
 Pro Pro Asp Arg Val Glu Ala Ala Cys Gln Ala Val Leu Glu Leu Cys
                 245                 250                 255    
 Arg Lys Glu Leu Pro Gly Asp Val Leu Val Phe Leu Pro Ser Glu Glu
             260                 265                 270        
 Glu Ile Ser Leu Cys Cys Glu Ser Leu Ser Arg Glu Val Glu Ser Leu
         275                 280                 285            
 Leu Leu Gln Gly Leu Pro Pro Arg Val Leu Pro Leu His Pro Asp Cys
     290                 295                 300                
 Gly Arg Ala Val Gln Ala Val Tyr Glu Asp Met Asp Ala Arg Lys Val
 305                 310                 315                 320
 Val Val Thr His Trp Leu Ala Asp Phe Ser Phe Ser Leu Pro Ser Ile
                 325                 330                 335    
 Gln His Val Ile Asp Ser Gly Leu Glu Leu Arg Ser Val Phe Phe Pro
             340                 345                 350        
 Ser Gly Ser Cys Leu Cys Leu Tyr Pro Lys Ser Phe Leu Glu Leu Glu
         355                 360                 365            
 Ala Pro Pro Leu Pro Gln Pro Arg Val Cys Glu Glu Asn Leu Ser Ser
     370                 375                 380                
 Leu Val Leu Leu Leu Lys Arg Arg Gln Ile Ala Glu Pro Gly Glu Cys
 385                 390                 395                 400
 His Phe Leu Asp Gln Pro Ala Pro Glu Ala Leu Met Gln Ala Leu Glu
                 405                 410                 415    
 Asp Leu Asp Tyr Leu Ala Ala Leu Asp Asp Asp Gly Asp Leu Ser Asp
             420                 425                 430        
 Leu Gly Val Ile Leu Ser Glu Phe Pro Leu Ala Pro Glu Leu Ala Lys
         435                 440                 445            
 Ala Leu Leu Ala Ser Cys Glu Phe Asp Cys Val Asp Glu Met Leu Thr
     450                 455                 460                
 Leu Ala Ala Met Leu Thr Ala Ala Pro Gly Phe Thr Arg Pro Pro Leu
 465                 470                 475                 480
 Ser Ala Glu Glu Ala Ala Leu Arg Arg Ala Leu Glu His Thr Asp Gly
                 485                 490                 495    
 Asp His Ser Ser Leu Ile Gln Val Tyr Glu Ala Phe Ile Gln Ser Gly
             500                 505                 510        
 Ala Asp Glu Ala Trp Cys Gln Ala Arg Gly Leu Asn Trp Ala Ala Leu
         515                 520                 525            
 Cys Gln Ala His Lys Leu Arg Gly Glu Leu Leu Glu Leu Met Gln Arg
     530                 535                 540                
 Ile Glu Leu Pro Leu Ser Leu Pro Ala Phe Gly Ser Glu Gln Asn Arg
 545                 550                 555                 560
 Arg Asp Leu Gln Lys Ala Leu Val Ser Gly Tyr Phe Leu Lys Val Ala
                 565                 570                 575    
 Arg Asp Thr Asp Gly Thr Gly Asn Tyr Leu Leu Leu Thr His Lys His
             580                 585                 590        
 Val Ala Gln Leu Ser Ser Tyr Cys Cys Tyr Arg Ser Arg Arg Ala Pro
         595                 600                 605            
 Ala Arg Pro Pro Pro Trp Val Leu Tyr His Asn Phe Thr Ile Ser Lys
     610                 615                 620                
 Asp Asn Cys Leu Ser Ile Val Ser Glu Ile Gln Pro Gln Met Leu Val
 625                 630                 635                 640
 Glu Leu Ala Pro Pro Tyr Phe Leu Ser Asn Leu Pro Pro Ser Glu Ser
                 645                 650                 655    
 Arg Asp Leu Leu Asn Gln Leu Arg Glu Gly Met Ala Asp Ser Thr Ala
             660                 665                 670        
 Gly Ser Lys Ser Ser Ser Ala Gln Glu Phe Arg Asp Pro Cys Val Leu
         675                 680                 685            
 Gln
    



      <210> 574
      <211> 246
      <212> PRT
      <213> Homo sapiens


      <400> 574
 Met Lys Ile Glu Lys Ser Phe Asp Ala His Pro Arg Lys Glu Ser Gln
   1               5                  10                  15    
 Val Arg Gln Leu Ala Trp Val Gly Asp Gly Val Trp Val Ser Ile Arg
              20                  25                  30        
 Leu Asp Ser Thr Leu Arg Leu Tyr His Ala His Thr Tyr Gln His Leu
          35                  40                  45            
 Gln Asp Val Asp Ile Glu Pro Tyr Val Ser Lys Met Leu Gly Thr Gly
      50                  55                  60                
 Lys Leu Gly Phe Ser Phe Val Arg Ile Thr Ala Leu Met Val Ser Cys
  65                  70                  75                  80
 Asn Arg Leu Trp Val Gly Thr Gly Asn Gly Val Ile Ile Ser Ile Pro
                  85                  90                  95    
 Leu Thr Glu Thr Asn Lys Thr Ser Gly Val Pro Gly Asn Arg Pro Gly
             100                 105                 110        
 Ser Val Ile Arg Val Tyr Gly Asp Glu Asn Ser Asp Lys Val Thr Pro
         115                 120                 125            
 Gly Thr Phe Ile Pro Tyr Cys Ser Met Ala His Ala Gln Leu Cys Phe
     130                 135                 140                
 His Gly His Arg Asp Ala Val Lys Phe Phe Val Ala Val Pro Gly Gln
 145                 150                 155                 160
 Val Ile Ser Pro Gln Ser Ser Ser Ser Gly Thr Asp Leu Thr Gly Asp
                 165                 170                 175    
 Lys Ala Gly Pro Ser Ala Gln Glu Pro Gly Ser Gln Thr Pro Leu Lys
             180                 185                 190        
 Ser Met Leu Val Ile Ser Gly Gly Glu Gly Tyr Ile Asp Phe Arg Met
         195                 200                 205            
 Gly Asp Glu Gly Gly Glu Ser Glu Leu Leu Gly Glu Asp Leu Pro Leu
     210                 215                 220                
 Glu Pro Ser Val Thr Lys Ala Glu Arg Ser His Leu Ile Val Trp Gln
 225                 230                 235                 240
 Val Met Tyr Gly Asn Glu
                 245    



      <210> 575
      <211> 685
      <212> PRT
      <213> Homo sapiens


      <400> 575
 Met Gly Val Ala Asn Pro Glu Val Ala Gly Gly Arg Ala Pro Phe Pro
   1               5                  10                  15    
 Glu Cys Thr Ala Ala Ala Ala Phe Arg Asn Arg Phe Ser Phe Gly Pro
              20                  25                  30        
 Gly Arg Pro Gly Gly Glu Asp Trp Cys Gly Leu Ala Met Asp Gly Leu
          35                  40                  45            
 Gln Ala Ser Ala Gly Pro Leu Arg Arg Gly Arg Pro Arg Arg Arg Arg
      50                  55                  60                
 Lys Pro Gln Pro His Ser Gly Ser Val Leu Ala Leu Pro Leu Arg Ser
  65                  70                  75                  80
 Arg Lys Ile Arg Lys Gln Leu Arg Ser Val Val Ser Arg Met Ala Ala
                  85                  90                  95    
 Leu Arg Thr Gln Thr Leu Pro Ser Glu Asn Ser Glu Glu Ser Arg Val
             100                 105                 110        
 Glu Ser Thr Ala Asp Asp Leu Gly Asp Ala Leu Pro Gly Gly Ala Ala
         115                 120                 125            
 Val Ala Ala Val Pro Asp Ala Ala Arg Arg Glu Pro Tyr Gly His Leu
     130                 135                 140                
 Gly Pro Ala Glu Leu Leu Glu Ala Ser Pro Ala Ala Arg Ser Leu Gln
 145                 150                 155                 160
 Thr Pro Ser Ala Arg Leu Val Pro Ala Ser Ala Pro Pro Ala Arg Leu
                 165                 170                 175    
 Val Glu Val Pro Ala Ala Pro Val Arg Val Val Glu Thr Ser Ala Leu
             180                 185                 190        
 Leu Cys Thr Ala Gln His Leu Ala Ala Val Gln Ser Ser Gly Ala Pro
         195                 200                 205            
 Ala Thr Ala Ser Gly Pro Gln Val Asp Asn Thr Gly Gly Glu Pro Ala
     210                 215                 220                
 Trp Asp Ser Pro Leu Arg Arg Val Leu Ala Glu Leu Asn Arg Ile Pro
 225                 230                 235                 240
 Ser Ser Arg Arg Arg Ala Ala Arg Leu Phe Glu Trp Leu Ile Ala Pro
                 245                 250                 255    
 Met Pro Pro Asp His Phe Tyr Arg Arg Leu Trp Glu Arg Glu Ala Val
             260                 265                 270        
 Leu Val Arg Arg Gln Asp His Thr Tyr Tyr Gln Gly Leu Phe Ser Thr
         275                 280                 285            
 Ala Asp Leu Asp Ser Met Leu Arg Asn Glu Glu Val Gln Phe Gly Gln
     290                 295                 300                
 His Leu Asp Ala Ala Arg Tyr Ile Asn Gly Arg Arg Glu Thr Leu Asn
 305                 310                 315                 320
 Pro Pro Gly Arg Ala Leu Pro Ala Ala Ala Trp Ser Leu Tyr Gln Ala
                 325                 330                 335    
 Gly Cys Ser Leu Arg Leu Leu Cys Pro Gln Ala Phe Ser Thr Thr Val
             340                 345                 350        
 Trp Gln Phe Leu Ala Val Leu Gln Glu Gln Phe Gly Ser Met Ala Gly
         355                 360                 365            
 Ser Asn Val Tyr Leu Thr Pro Pro Asn Ser Gln Gly Phe Ala Pro His
     370                 375                 380                
 Tyr Asp Asp Ile Glu Ala Phe Val Leu Gln Leu Glu Gly Arg Lys Leu
 385                 390                 395                 400
 Trp Arg Val Tyr Arg Pro Arg Ala Pro Thr Glu Glu Leu Ala Leu Thr
                 405                 410                 415    
 Ser Ser Pro Asn Phe Ser Gln Asp Asp Leu Gly Glu Pro Val Leu Gln
             420                 425                 430        
 Thr Val Leu Glu Pro Gly Asp Leu Leu Tyr Phe Pro Arg Gly Phe Ile
         435                 440                 445            
 His Gln Ala Glu Cys Gln Asp Gly Val His Ser Leu His Leu Thr Leu
     450                 455                 460                
 Ser Thr Tyr Gln Arg Asn Thr Trp Gly Asp Phe Leu Glu Ala Ile Leu
 465                 470                 475                 480
 Pro Leu Ala Val Gln Ala Ala Met Glu Glu Asn Val Glu Phe Arg Arg
                 485                 490                 495    
 Gly Leu Pro Arg Asp Phe Met Asp Tyr Met Gly Ala Gln His Ser Asp
             500                 505                 510        
 Ser Lys Asp Pro Arg Arg Thr Ala Phe Met Glu Lys Val Arg Val Leu
         515                 520                 525            
 Val Ala Arg Leu Gly His Phe Ala Pro Val Asp Ala Val Ala Asp Gln
     530                 535                 540                
 Arg Ala Lys Asp Phe Ile His Asp Ser Leu Pro Pro Val Leu Thr Asp
 545                 550                 555                 560
 Arg Glu Arg Ala Leu Ser Val Tyr Gly Leu Pro Ile Arg Trp Glu Ala
                 565                 570                 575    
 Gly Glu Pro Val Asn Val Gly Ala Gln Leu Thr Thr Glu Thr Glu Val
             580                 585                 590        
 His Met Leu Gln Asp Gly Ile Ala Arg Leu Val Gly Glu Gly Gly His
         595                 600                 605            
 Leu Phe Leu Tyr Tyr Thr Val Glu Asn Ser Arg Val Tyr His Leu Glu
     610                 615                 620                
 Glu Pro Lys Cys Leu Glu Ile Tyr Pro Gln Gln Ala Asp Ala Met Glu
 625                 630                 635                 640
 Leu Leu Leu Gly Ser Tyr Pro Glu Phe Val Arg Val Gly Asp Leu Pro
                 645                 650                 655    
 Cys Asp Ser Val Glu Asp Gln Leu Ser Leu Ala Thr Thr Leu Tyr Asp
             660                 665                 670        
 Lys Gly Leu Leu Leu Thr Lys Met Pro Leu Ala Leu Asn
         675                 680                 685



      <210> 576
      <211> 1177
      <212> PRT
      <213> Homo sapiens


      <400> 576
 Met Lys Thr Gln Pro Pro Leu Ser Arg Met Asn Arg Glu Glu Leu Glu
   1               5                  10                  15    
 Asp Ser Phe Phe Arg Leu Arg Glu Asp His Met Leu Val Lys Glu Leu
              20                  25                  30        
 Ser Trp Lys Gln Gln Asp Glu Ile Lys Ser Ile Ile Ser Phe Ser Ser
          35                  40                  45            
 Val Ile Ser Met Ala Lys Pro Ile Gly Leu Cys Met Pro Asn Ser Ala
      50                  55                  60                
 His Ile Met Ala Ser Asn Thr Met Gln Val Glu Glu Pro Pro Lys Ser
  65                  70                  75                  80
 Pro Glu Lys Met Trp Pro Lys Asp Glu Asn Phe Glu Gln Arg Ser Ser
                  85                  90                  95    
 Leu Glu Cys Ala Gln Lys Ala Ala Glu Leu Arg Ala Ser Ile Lys Glu
             100                 105                 110        
 Lys Val Glu Leu Ile Arg Leu Lys Lys Leu Leu His Glu Arg Asn Ala
         115                 120                 125            
 Ser Leu Val Met Thr Lys Ala Gln Leu Thr Glu Val Gln Glu Ile Phe
     130                 135                 140                
 Thr Val Met Ile Phe Phe Lys Pro Asp Asn Ser Pro Gln Glu Asn Ala
 145                 150                 155                 160
 Arg Val Ala Gly Val Trp Arg Pro Leu Val Leu Ser Asp Met Thr Ile
                 165                 170                 175    
 Pro Arg Gly Thr Phe Leu Leu Thr Gln Asn Gln Gly Ile Leu Ser Ala
             180                 185                 190        
 Ala His Glu Ala Leu Leu Lys Gln Val Asn Glu Leu Arg Ala Glu Leu
         195                 200                 205            
 Lys Glu Glu Ser Lys Lys Ala Val Ser Leu Lys Ser Gln Leu Glu Asp
     210                 215                 220                
 Val Ser Ile Leu Gln Met Thr Leu Lys Glu Glu Arg Val Glu Asp Leu
 225                 230                 235                 240
 Glu Lys Glu Arg Lys Leu Leu Asn Asp Asn Tyr Asp Lys Leu Leu Glu
                 245                 250                 255    
 Ser Met Leu Asp Ser Ser Asp Ser Ser Ser Gln Pro His Trp Ser Asn
             260                 265                 270        
 Glu Leu Ile Ala Glu Gln Leu Gln Gln Gln Val Ser Gln Leu Gln Asp
         275                 280                 285            
 Gln Leu Asp Ala Glu Leu Glu Asp Lys Arg Lys Val Leu Leu Glu Leu
     290                 295                 300                
 Ser Arg Glu Lys Ala Gln Asn Glu Asp Leu Lys Leu Glu Val Thr Asn
 305                 310                 315                 320
 Ile Leu Gln Lys His Lys Gln Glu Val Glu Leu Leu Gln Asn Ala Ala
                 325                 330                 335    
 Thr Ile Ser Gln Pro Pro Asp Arg Gln Ser Glu Pro Ala Thr His Pro
             340                 345                 350        
 Ala Val Leu Gln Glu Asn Thr Gln Ile Glu Pro Ser Glu Pro Lys Asn
         355                 360                 365            
 Gln Glu Glu Lys Lys Leu Ser Gln Val Leu Asn Glu Leu Gln Val Ser
     370                 375                 380                
 His Ala Glu Thr Thr Leu Glu Leu Glu Lys Thr Arg Asp Met Leu Ile
 385                 390                 395                 400
 Leu Gln Arg Lys Ile Asn Val Cys Tyr Gln Val Gln Gly Lys Met Glu
                 405                 410                 415    
 Glu Leu Glu Ala Met Met Thr Lys Ala Asp Asn Asp Asn Arg Asp His
             420                 425                 430        
 Lys Glu Lys Leu Glu Arg Leu Thr Arg Leu Leu Asp Leu Lys Asn Asn
         435                 440                 445            
 Arg Ile Lys Gln Leu Glu Glu Gln Leu Lys Asp Val Ala Tyr Gly Thr
     450                 455                 460                
 Arg Pro Leu Ser Leu Cys Leu Glu Thr Leu Pro Ala His Gly Asp Glu
 465                 470                 475                 480
 Asp Lys Val Asp Ile Ser Leu Leu His Gln Gly Glu Asn Leu Phe Glu
                 485                 490                 495    
 Leu His Ile His Gln Ala Phe Leu Thr Ser Ala Ala Leu Ala Gln Ala
             500                 505                 510        
 Gly Asp Thr Gln Pro Thr Thr Phe Cys Thr Tyr Ser Phe Tyr Asp Phe
         515                 520                 525            
 Glu Thr His Cys Thr Pro Leu Ser Val Gly Pro Gln Pro Leu Tyr Asp
     530                 535                 540                
 Phe Thr Ser Gln Tyr Val Met Glu Thr Asp Ser Leu Phe Leu His Tyr
 545                 550                 555                 560
 Leu Gln Glu Ala Ser Ala Arg Leu Asp Ile His Gln Ala Met Ala Ser
                 565                 570                 575    
 Glu His Ser Thr Leu Ala Ala Gly Trp Ile Cys Phe Asp Arg Val Leu
             580                 585                 590        
 Glu Thr Val Glu Lys Val His Gly Leu Ala Thr Leu Ile Gly Ala Gly
         595                 600                 605            
 Gly Glu Glu Phe Gly Val Leu Glu Tyr Trp Met Arg Leu Arg Phe Pro
     610                 615                 620                
 Ile Lys Pro Ser Leu Gln Ala Cys Asn Lys Arg Lys Lys Ala Gln Val
 625                 630                 635                 640
 Tyr Leu Ser Thr Asp Val Leu Gly Gly Arg Lys Ala Gln Glu Glu Glu
                 645                 650                 655    
 Phe Arg Ser Glu Ser Trp Glu Pro Gln Asn Glu Leu Trp Ile Glu Ile
             660                 665                 670        
 Thr Lys Cys Cys Gly Leu Arg Ser Arg Trp Leu Gly Thr Gln Pro Ser
         675                 680                 685            
 Pro Tyr Ala Val Tyr Arg Phe Phe Thr Phe Ser Asp His Asp Thr Ala
     690                 695                 700                
 Ile Ile Pro Ala Ser Asn Asn Pro Tyr Phe Arg Asp Gln Ala Arg Phe
 705                 710                 715                 720
 Pro Val Leu Val Thr Ser Asp Leu Asp His Tyr Leu Arg Arg Glu Ala
                 725                 730                 735    
 Leu Ser Ile His Val Phe Asp Asp Glu Asp Leu Glu Pro Gly Ser Tyr
             740                 745                 750        
 Leu Gly Arg Ala Arg Val Pro Leu Leu Pro Leu Ala Lys Asn Glu Ser
         755                 760                 765            
 Ile Lys Gly Asp Phe Asn Leu Thr Asp Pro Ala Glu Lys Pro Asn Gly
     770                 775                 780                
 Ser Ile Gln Val Gln Leu Asp Trp Lys Phe Pro Tyr Ile Pro Pro Glu
 785                 790                 795                 800
 Ser Phe Leu Lys Pro Glu Ala Gln Thr Lys Gly Lys Asp Thr Lys Asp
                 805                 810                 815    
 Ser Ser Lys Ile Ser Ser Glu Glu Glu Lys Ala Ser Phe Pro Ser Gln
             820                 825                 830        
 Val Val Lys Leu Pro Ala Cys Asn Ala Ile Ser Asp Leu Ser Ile Gln
         835                 840                 845            
 Asp Gln Met Ala Ser Pro Glu Val Pro Ile Glu Ala Gly Gln Tyr Arg
     850                 855                 860                
 Ser Lys Arg Lys Pro Pro His Gly Gly Glu Arg Lys Glu Lys Glu His
 865                 870                 875                 880
 Gln Val Val Ser Tyr Ser Arg Arg Lys His Gly Lys Arg Ile Gly Val
                 885                 890                 895    
 Gln Gly Lys Asn Arg Met Glu Tyr Leu Ser Leu Asn Ile Leu Asn Gly
             900                 905                 910        
 Asn Thr Pro Glu Val Asn Tyr Thr Glu Trp Lys Phe Ser Glu Thr Asn
         915                 920                 925            
 Ser Phe Ile Gly Asp Gly Phe Lys Asn Gln His Glu Glu Glu Glu Met
     930                 935                 940                
 Thr Leu Ser His Ser Ala Leu Lys Gln Lys Glu Pro Leu His Pro Val
 945                 950                 955                 960
 Asn Asp Lys Glu Ser Ser Glu Gln Gly Ser Glu Val Ser Glu Ala Gln
                 965                 970                 975    
 Thr Thr Asp Ser Asp Asp Val Ile Val Pro Pro Met Ser Gln Lys Tyr
             980                 985                 990        
 Pro Lys Ala Glu Leu Asn Lys His Phe Pro Tyr Gln Asp Ser Glu Lys
         995                1000                1005            
 Met Cys Ile Glu Ile Val Ser Leu Ala Phe Tyr Pro Glu Ala Glu Val
    1010                1015                1020                
 Met Ser Asp Glu Asn Ile Lys Gln Val Tyr Val Glu Tyr Lys Phe Tyr
1025                1030                1035                1040
 Asp Leu Pro Leu Ser Glu Thr Glu Thr Pro Val Ser Leu Arg Lys Pro
                1045                1050                1055    
 Arg Ala Gly Glu Glu Ile His Phe His Phe Ser Lys Val Ile Asp Leu
            1060                1065                1070        
 Asp Pro Gln Glu Gln Gln Gly Arg Arg Arg Phe Leu Phe Asp Met Leu
        1075                1080                1085            
 Asn Gly Gln Asp Pro Asp Gln Gly His Leu Lys Phe Thr Val Val Ser
    1090                1095                1100                
 Asp Pro Leu Asp Glu Glu Lys Lys Glu Cys Glu Glu Val Gly Tyr Ala
1105                1110                1115                1120
 Tyr Leu Gln Leu Trp Gln Ile Leu Glu Ser Gly Arg Asp Ile Leu Glu
                1125                1130                1135    
 Gln Glu Leu Asp Ile Val Ser Pro Glu Asp Leu Ala Thr Pro Ile Gly
            1140                1145                1150        
 Arg Leu Lys Val Ser Leu Gln Ala Ala Ala Val Leu His Ala Ile Tyr
        1155                1160                1165            
 Lys Glu Met Thr Glu Asp Leu Phe Ser
    1170                1175        



      <210> 577
      <211> 429
      <212> PRT
      <213> Homo sapiens


      <400> 577
 Met Ala Gln Pro Gly Thr Leu Asn Leu Asn Asn Glu Val Val Lys Met
   1               5                  10                  15    
 Arg Lys Glu Val Lys Arg Ile Arg Val Leu Val Ile Arg Lys Leu Val
              20                  25                  30        
 Arg Ser Val Gly Arg Leu Lys Ser Lys Lys Gly Thr Glu Asp Ala Leu
          35                  40                  45            
 Leu Lys Asn Gln Arg Arg Ala Gln Arg Leu Leu Glu Glu Ile His Ala
      50                  55                  60                
 Met Lys Glu Leu Lys Pro Asp Ile Val Thr Lys Ser Ala Leu Gly Asp
  65                  70                  75                  80
 Asp Ile Asn Phe Glu Lys Ile Phe Lys Lys Pro Asp Ser Thr Ala Thr
                  85                  90                  95    
 Glu Arg Ala Ile Ala Arg Leu Ala Val His Pro Leu Leu Lys Lys Lys
             100                 105                 110        
 Ile Asp Val Leu Lys Ala Ala Val Gln Ala Phe Lys Glu Ala Arg Gln
         115                 120                 125            
 Asn Val Ala Glu Val Glu Ser Ser Lys Asn Ala Ser Glu Asp Asn His
     130                 135                 140                
 Ser Glu Asn Thr Leu Tyr Ser Asn Asp Asn Gly Ser Asn Leu Gln Arg
 145                 150                 155                 160
 Glu Ala Thr Val Ile Ser Glu Gln Lys Val Lys Glu Thr Lys Ile Leu
                 165                 170                 175    
 Ala Lys Lys Pro Ile His Asn Ser Lys Glu Lys Ile Ala Lys Met Glu
             180                 185                 190        
 His Gly Pro Lys Ala Val Thr Ile Ala Asn Ser Pro Ser Lys Pro Ser
         195                 200                 205            
 Glu Lys Asp Ser Val Val Ser Leu Glu Ser Gln Lys Thr Pro Ala Asp
     210                 215                 220                
 Pro Lys Leu Lys Thr Leu Ser Gln Thr Lys Lys Asn Lys Gly Ser Asp
 225                 230                 235                 240
 Ser Ser Leu Ser Gly Asn Ser Asp Gly Gly Glu Glu Phe Cys Glu Glu
                 245                 250                 255    
 Glu Lys Glu Tyr Phe Asp Asp Ser Thr Glu Glu Arg Phe Tyr Lys Gln
             260                 265                 270        
 Ser Ser Met Ser Glu Asp Ser Asp Ser Gly Asp Asp Phe Phe Ile Gly
         275                 280                 285            
 Lys Val Arg Arg Thr Arg Lys Lys Glu Ser Ser Cys His Ser Ser Val
     290                 295                 300                
 Lys Glu Gln Lys Pro Leu Glu Lys Val Phe Leu Lys Glu Asp Thr Gly
 305                 310                 315                 320
 Glu Thr His Gly Asp Thr Arg Asn Asp Lys Ile Lys Pro Ser Thr Glu
                 325                 330                 335    
 Thr Arg Lys Leu Glu Ser Val Phe Phe His Ser Leu Ser Gly Ser Lys
             340                 345                 350        
 Ser Ser Arg Arg Asn Phe Lys Glu Gln Ala Pro Lys Thr Arg Ser Leu
         355                 360                 365            
 Asp Phe Pro Gln Asn Glu Pro Gln Ile Lys Asn Gln Phe Asn Lys Lys
     370                 375                 380                
 Leu Ser Gly Arg Leu Glu Asn Thr Lys Gln Gln Leu Gln Leu Pro Leu
 385                 390                 395                 400
 His Pro Ser Trp Glu Ala Ser Arg Arg Arg Lys Glu Gln Gln Ser Asn
                 405                 410                 415    
 Ile Ala Val Phe Gln Gly Lys Lys Ile Thr Phe Asp Asp
             420                 425                



      <210> 578
      <211> 215
      <212> PRT
      <213> Homo sapiens


      <400> 578
 Met Arg Gly Leu Arg Trp Arg Tyr Thr Arg Leu Pro Ser Gln Val Glu
   1               5                  10                  15    
 Asp Thr Leu Ser Gly Glu Glu Gly Asn Glu Glu Glu Glu Glu Glu Glu
              20                  25                  30        
 Ala Ala Pro Asp Pro Ala Ala Ala Pro Glu Asp Pro Thr Val Pro Gln
          35                  40                  45            
 Leu Thr Glu Ala Ser Gln Val Leu Ser Ala Ser Glu Ile Arg Gln Leu
      50                  55                  60                
 Ser Phe His Phe Pro Pro Arg Val Thr Gly His Pro Trp Ser Leu Val
  65                  70                  75                  80
 Phe Cys Thr Ser Arg Asp Gly Phe Ser Leu Gln Ser Leu Tyr Arg Arg
                  85                  90                  95    
 Met Glu Gly Cys Ser Gly Pro Val Leu Leu Val Leu Arg Asp Gln Asp
             100                 105                 110        
 Gly Gln Ile Phe Gly Ala Phe Ser Ser Ser Ala Ile Arg Leu Ser Lys
         115                 120                 125            
 Gly Phe Tyr Gly Thr Gly Glu Thr Phe Leu Phe Ser Phe Ser Pro Gln
     130                 135                 140                
 Leu Lys Val Phe Lys Trp Thr Gly Ser Asn Ser Phe Phe Val Lys Gly
 145                 150                 155                 160
 Asp Leu Asp Ser Leu Met Met Gly Ser Gly Ser Gly Arg Phe Gly Leu
                 165                 170                 175    
 Trp Leu Asp Gly Asp Leu Phe Arg Gly Gly Ser Ser Pro Cys Pro Thr
             180                 185                 190        
 Phe Asn Asn Glu Val Leu Ala Arg Gln Glu Gln Phe Cys Ile Gln Glu
         195                 200                 205            
 Leu Glu Ala Trp Leu Leu Ser
     210                 215



      <210> 579
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 579
 Met Leu Pro Lys Phe Asn Pro Lys Glu Ile Lys Val Val Tyr Leu Arg
   1               5                  10                  15    
 Cys Thr Gly Gly Glu Ile Gly Pro Leu Gly Leu Ser Pro Lys Lys Val
              20                  25                  30        
 Gly Asp Asp Ile Ala Lys Ala Thr Gly Asp Trp Lys Gly Leu Arg Ile
          35                  40                  45            
 Thr Val Lys Leu Thr Ile Gln Asn Arg Gln Ala Gln Ile Glu Val Val
      50                  55                  60                
 Pro Ser Ala Ser Ala Leu Ile Ile Lys Ala Leu Lys Glu Pro Pro Arg
  65                  70                  75                  80
 Asp Arg Lys Lys Gln Lys Asn Ile Lys His Ser Gly Asn Ile Thr Phe
                  85                  90                  95    
 Asp Glu Ile Val Asn Ile Ala Arg Gln Met Arg His Arg Ser Leu Ala
             100                 105                 110        
 Arg Glu Leu Ser Gly Glu Ser Arg Thr Thr Cys Asn Arg His Asn Cys
         115                 120                 125            
 Ser Cys Val Phe His
     130            



      <210> 580
      <211> 1518
      <212> PRT
      <213> Homo sapiens


      <400> 580
 Met Ser Leu Pro Phe Tyr Gln Arg Cys His Gln His Tyr Asp Leu Ser
   1               5                  10                  15    
 Tyr Arg Asn Lys Asp Val Arg Ser Thr Val Ser His Tyr Gln Arg Glu
              20                  25                  30        
 Lys Lys Arg Ser Ala Val Tyr Thr Gln Gly Ser Thr Ala Tyr Ser Ser
          35                  40                  45            
 Arg Ser Ser Ala Ala His Arg Arg Glu Ser Glu Ala Phe Arg Arg Ala
      50                  55                  60                
 Ser Ala Ser Ser Ser Gln Gln Gln Ala Ser Gln His Ala Leu Ser Ser
  65                  70                  75                  80
 Glu Val Ser Arg Lys Ala Ala Ser Ala Tyr Asp Tyr Gly Ser Ser His
                  85                  90                  95    
 Gly Leu Thr Asp Ser Ser Leu Leu Leu Asp Asp Tyr Ser Ser Lys Leu
             100                 105                 110        
 Ser Pro Lys Pro Lys Arg Ala Lys His Ser Leu Leu Ser Gly Glu Glu
         115                 120                 125            
 Lys Glu Asn Leu Pro Ser Asp Tyr Met Val Pro Ile Phe Ser Gly Arg
     130                 135                 140                
 Gln Lys His Val Ser Gly Ile Thr Asp Thr Glu Glu Glu Arg Ile Lys
 145                 150                 155                 160
 Glu Ala Ala Ala Tyr Ile Ala Gln Arg Asn Leu Leu Ala Ser Glu Glu
                 165                 170                 175    
 Gly Ile Thr Thr Pro Lys Gln Ser Thr Ala Ser Lys Gln Thr Thr Ala
             180                 185                 190        
 Ser Lys Gln Ser Thr Ala Ser Lys Gln Ser Thr Ala Ser Lys Gln Ser
         195                 200                 205            
 Thr Ala Ser Arg Gln Ser Met Ala Ser Arg Gln Ser Val Val Ser Lys
     210                 215                 220                
 Gln Ala Thr Ser Ala Leu Gln Gln Glu Glu Thr Ser Glu Lys Lys Ser
 225                 230                 235                 240
 Arg Lys Val Val Ile Arg Glu Lys Ala Glu Arg Leu Ser Leu Arg Lys
                 245                 250                 255    
 Thr Leu Glu Glu Thr Glu Thr Tyr His Ala Lys Leu Asn Glu Asp His
             260                 265                 270        
 Leu Leu His Ala Pro Glu Phe Ile Ile Lys Pro Arg Ser His Thr Val
         275                 280                 285            
 Trp Glu Lys Glu Asn Val Lys Leu His Cys Ser Ile Ala Gly Trp Pro
     290                 295                 300                
 Glu Pro Arg Val Thr Trp Tyr Lys Asn Gln Val Pro Ile Asn Val His
 305                 310                 315                 320
 Ala Asn Pro Gly Lys Tyr Ile Ile Glu Ser Arg Tyr Gly Met His Thr
                 325                 330                 335    
 Leu Glu Ile Asn Ala Cys Asp Phe Glu Asp Thr Ala Gln Tyr Arg Ala
             340                 345                 350        
 Ser Ala Met Asn Val Lys Gly Glu Leu Ser Ala Tyr Ala Ser Val Val
         355                 360                 365            
 Val Lys Arg Tyr Lys Gly Glu Phe Asp Glu Thr Arg Phe His Ala Gly
     370                 375                 380                
 Ala Ser Thr Met Pro Leu Ser Phe Gly Val Thr Pro Tyr Gly Tyr Ala
 385                 390                 395                 400
 Ser Arg Phe Glu Ile His Phe Asp Asp Lys Phe Asp Val Ser Phe Gly
                 405                 410                 415    
 Arg Glu Gly Glu Thr Met Ser Leu Gly Cys Arg Val Val Ile Thr Pro
             420                 425                 430        
 Glu Ile Lys His Phe Gln Pro Glu Ile Arg Trp Tyr Arg Asn Gly Val
         435                 440                 445            
 Pro Leu Ser Pro Ser Lys Trp Val Gln Thr Leu Trp Ser Gly Glu Arg
     450                 455                 460                
 Ala Thr Leu Thr Phe Ser His Leu Asn Lys Glu Asp Glu Gly Leu Tyr
 465                 470                 475                 480
 Thr Ile Arg Val Arg Met Gly Glu Tyr Tyr Glu Gln Tyr Ser Ala Tyr
                 485                 490                 495    
 Val Phe Val Arg Asp Ala Asp Ala Glu Ile Glu Gly Ala Pro Ala Ala
             500                 505                 510        
 Pro Leu Asp Val Lys Cys Leu Glu Ala Asn Lys Asp Tyr Ile Ile Ile
         515                 520                 525            
 Ser Trp Lys Gln Pro Ala Val Asp Gly Gly Ser Pro Ile Leu Gly Tyr
     530                 535                 540                
 Phe Ile Asp Lys Cys Glu Val Gly Thr Asp Ser Trp Ser Gln Cys Asn
 545                 550                 555                 560
 Asp Thr Pro Val Lys Phe Ala Arg Phe Pro Val Thr Gly Leu Ile Glu
                 565                 570                 575    
 Gly Arg Ser Tyr Ile Phe Arg Val Arg Ala Val Asn Lys Met Gly Ile
             580                 585                 590        
 Gly Phe Pro Ser Arg Val Ser Glu Pro Val Ala Ala Leu Asp Pro Ala
         595                 600                 605            
 Glu Lys Ala Arg Leu Lys Ser Arg Pro Ser Ala Pro Trp Thr Gly Gln
     610                 615                 620                
 Ile Ile Val Thr Glu Glu Glu Pro Ser Glu Gly Ile Val Pro Gly Pro
 625                 630                 635                 640
 Pro Thr Asp Leu Ser Val Thr Glu Ala Thr Arg Ser Tyr Val Val Leu
                 645                 650                 655    
 Ser Trp Lys Pro Pro Gly Gln Arg Gly His Glu Gly Ile Met Tyr Phe
             660                 665                 670        
 Val Glu Lys Cys Glu Ala Gly Thr Glu Asn Trp Gln Arg Val Asn Thr
         675                 680                 685            
 Glu Leu Pro Val Lys Ser Pro Arg Phe Ala Leu Phe Asp Leu Ala Glu
     690                 695                 700                
 Gly Lys Ser Tyr Cys Phe Arg Val Arg Cys Ser Asn Ser Ala Gly Val
 705                 710                 715                 720
 Gly Glu Pro Ser Glu Ala Thr Glu Val Thr Val Val Gly Asp Lys Leu
                 725                 730                 735    
 Asp Ile Pro Lys Ala Pro Gly Lys Ile Ile Pro Ser Arg Asn Thr Asp
             740                 745                 750        
 Thr Ser Val Val Val Ser Trp Glu Glu Ser Lys Asp Ala Lys Glu Leu
         755                 760                 765            
 Val Gly Tyr Tyr Ile Glu Ala Ser Val Ala Gly Ser Gly Lys Trp Glu
     770                 775                 780                
 Pro Cys Asn Asn Asn Pro Val Lys Gly Ser Arg Phe Thr Cys His Gly
 785                 790                 795                 800
 Leu Val Thr Gly Gln Ser Tyr Ile Phe Arg Val Arg Ala Val Asn Ala
                 805                 810                 815    
 Ala Gly Leu Ser Glu Tyr Ser Gln Asp Ser Glu Ala Ile Glu Val Lys
             820                 825                 830        
 Ala Ala Ile Ala Pro Pro Ser Pro Pro Cys Asp Ile Thr Cys Leu Glu
         835                 840                 845            
 Ser Phe Arg Asp Ser Met Val Leu Gly Trp Lys Gln Pro Asp Lys Ile
     850                 855                 860                
 Gly Gly Ala Glu Ile Thr Gly Tyr Tyr Val Asn Tyr Arg Glu Val Ile
 865                 870                 875                 880
 Asp Gly Val Pro Gly Lys Trp Arg Glu Ala Asn Val Lys Ala Val Ser
                 885                 890                 895    
 Glu Glu Ala Tyr Lys Ile Ser Asn Leu Lys Glu Asn Met Val Tyr Gln
             900                 905                 910        
 Phe Gln Val Ala Ala Met Asn Met Ala Gly Leu Gly Ala Pro Ser Ala
         915                 920                 925            
 Val Ser Glu Cys Phe Lys Cys Glu Glu Trp Thr Ile Ala Val Pro Gly
     930                 935                 940                
 Pro Pro His Ser Leu Lys Cys Ser Glu Val Arg Lys Asp Ser Leu Val
 945                 950                 955                 960
 Leu Gln Trp Lys Pro Pro Val His Ser Gly Arg Thr Pro Val Thr Gly
                 965                 970                 975    
 Tyr Phe Val Asp Leu Lys Glu Ala Lys Ala Lys Glu Asp Gln Trp Arg
             980                 985                 990        
 Gly Leu Asn Glu Ala Ala Ile Lys Asn Val Tyr Leu Lys Val Arg Gly
         995                1000                1005            
 Leu Lys Glu Gly Val Ser Tyr Val Phe Arg Val Arg Ala Ile Asn Gln
    1010                1015                1020                
 Ala Gly Val Gly Lys Pro Ser Asp Leu Ala Gly Pro Val Val Ala Glu
1025                1030                1035                1040
 Thr Arg Pro Gly Arg Lys Glu Val Val Val Asn Val Asp Asp Asp Gly
                1045                1050                1055    
 Val Ile Ser Leu Asn Phe Glu Cys Asp Lys Met Thr Pro Lys Ser Glu
            1060                1065                1070        
 Phe Ser Trp Ser Lys Asp Tyr Val Ser Thr Glu Asp Ser Pro Arg Leu
        1075                1080                1085            
 Glu Val Glu Ser Lys Gly Asn Lys Thr Lys Met Thr Phe Lys Asp Leu
    1090                1095                1100                
 Gly Met Asp Asp Leu Gly Ile Tyr Ser Cys Asp Val Thr Asp Thr Asp
1105                1110                1115                1120
 Gly Ile Ala Ser Ser Tyr Leu Ile Asp Glu Glu Glu Leu Lys Arg Leu
                1125                1130                1135    
 Leu Ala Leu Ser His Glu His Lys Phe Pro Thr Val Pro Val Lys Ser
            1140                1145                1150        
 Glu Leu Ala Val Glu Ile Leu Glu Lys Gly Gln Val Arg Phe Trp Met
        1155                1160                1165            
 Gln Ala Glu Lys Leu Ser Gly Asn Ala Lys Val Asn Tyr Ile Phe Asn
    1170                1175                1180                
 Glu Lys Glu Ile Phe Glu Gly Pro Lys Tyr Lys Met His Ile Asp Arg
1185                1190                1195                1200
 Asn Thr Gly Ile Ile Glu Met Phe Met Glu Lys Leu Gln Asp Glu Asp
                1205                1210                1215    
 Glu Gly Thr Tyr Thr Phe Gln Leu Gln Asp Gly Lys Ala Thr Asn His
            1220                1225                1230        
 Ser Thr Val Val Leu Val Gly Asp Val Phe Lys Lys Leu Gln Lys Glu
        1235                1240                1245            
 Ala Glu Phe Gln Arg Gln Glu Trp Ile Arg Lys Gln Gly Pro His Phe
    1250                1255                1260                
 Val Glu Tyr Leu Ser Trp Glu Val Thr Gly Glu Cys Asn Val Leu Leu
1265                1270                1275                1280
 Lys Cys Lys Val Ala Asn Ile Lys Lys Glu Thr His Ile Val Trp Tyr
                1285                1290                1295    
 Lys Asp Glu Arg Glu Ile Ser Val Asp Glu Lys His Asp Phe Lys Asp
            1300                1305                1310        
 Gly Ile Cys Thr Leu Leu Ile Thr Glu Phe Ser Lys Lys Asp Ala Gly
        1315                1320                1325            
 Ile Tyr Glu Val Ile Leu Lys Asp Asp Arg Gly Lys Asp Lys Ser Arg
    1330                1335                1340                
 Leu Lys Leu Val Asp Glu Ala Phe Lys Glu Leu Met Met Glu Val Cys
1345                1350                1355                1360
 Lys Lys Ile Ala Leu Ser Ala Thr Asp Leu Lys Ile Gln Ser Thr Ala
                1365                1370                1375    
 Glu Gly Ile Gln Leu Tyr Ser Phe Val Thr Tyr Tyr Val Glu Asp Leu
            1380                1385                1390        
 Lys Val Asn Trp Ser His Asn Gly Ser Ala Ile Arg Tyr Ser Asp Arg
        1395                1400                1405            
 Val Lys Thr Gly Val Thr Gly Glu Gln Ile Trp Leu Gln Ile Asn Glu
    1410                1415                1420                
 Pro Thr Pro Asn Asp Lys Gly Lys Tyr Val Met Glu Leu Phe Asp Gly
1425                1430                1435                1440
 Lys Thr Gly His Gln Lys Thr Val Asp Leu Ser Gly Gln Ala Tyr Asp
                1445                1450                1455    
 Glu Ala Tyr Ala Glu Phe Gln Arg Leu Lys Gln Ala Ala Ile Ala Glu
            1460                1465                1470        
 Lys Asn Arg Ala Arg Val Leu Gly Gly Leu Pro Asp Val Val Thr Ile
        1475                1480                1485            
 Gln Glu Gly Lys Ala Leu Asn Leu Thr Cys Asn Val Trp Gly Asp Pro
    1490                1495                1500                
 Pro Pro Glu Val Ser Trp Leu Lys Asn Glu Lys Ala Leu Ala
1505                1510                1515            



      <210> 581
      <211> 166
      <212> PRT
      <213> Homo sapiens


      <400> 581
 Met Ser Ser Asn Arg Pro Val Glu Ile Val Glu Asp Pro Arg Val Val
   1               5                  10                  15    
 Gly Ile Trp Thr Lys Asn Lys Glu Leu Glu Leu Ser Val Pro Lys Phe
              20                  25                  30        
 Lys Ile Asp Glu Phe Tyr Val Gly Pro Val Pro Pro Lys Gln Val Thr
          35                  40                  45            
 Phe Ala Lys Leu Asn Asp Asn Ile Arg Glu Asn Phe Leu Arg Asp Met
      50                  55                  60                
 Cys Lys Lys Tyr Gly Glu Val Glu Glu Val Glu Ile Leu Tyr Asn Pro
  65                  70                  75                  80
 Lys Thr Lys Lys His Leu Gly Ile Ala Lys Val Val Phe Ala Thr Val
                  85                  90                  95    
 Arg Gly Ala Lys Asp Ala Val Gln His Leu His Ser Thr Ser Val Met
             100                 105                 110        
 Gly Asn Ile Ile His Val Glu Leu Asp Thr Lys Gly Glu Pro Gly Arg
         115                 120                 125            
 Gly Gly Ala Trp Gly Asp Leu Ser Ala Arg Pro Phe Pro Ser Pro Pro
     130                 135                 140                
 Phe Leu Gln Arg Gly Glu Asp Pro Pro Ser Leu Phe Leu Gly Ile Pro
 145                 150                 155                 160
 Pro His Asn Leu Ile Ser
                 165    



      <210> 582
      <211> 851
      <212> PRT
      <213> Homo sapiens


      <400> 582
 Met Gly Lys Lys Ile Lys Lys Glu Val Glu Pro Pro Pro Lys Asp Val
   1               5                  10                  15    
 Phe Asp Pro Leu Met Ile Glu Ser Lys Lys Ala Ala Thr Val Val Leu
              20                  25                  30        
 Met Leu Asn Ser Pro Glu Glu Glu Ile Leu Ala Lys Ala Cys Glu Ala
          35                  40                  45            
 Ile Tyr Lys Phe Ala Leu Lys Gly Glu Glu Asn Lys Thr Thr Leu Leu
      50                  55                  60                
 Glu Leu Gly Ala Val Glu Pro Leu Thr Lys Leu Leu Thr His Glu Asp
  65                  70                  75                  80
 Lys Ile Val Arg Arg Asn Ala Thr Met Ile Phe Gly Ile Leu Ala Ser
                  85                  90                  95    
 Asn Asn Asp Val Lys Lys Leu Leu Arg Glu Leu Asp Val Met Asn Ser
             100                 105                 110        
 Val Ile Ala Gln Leu Ala Pro Glu Glu Glu Val Val Ile His Glu Phe
         115                 120                 125            
 Ala Ser Leu Cys Leu Ala Asn Met Ser Ala Glu Tyr Thr Ser Lys Val
     130                 135                 140                
 Gln Ile Phe Glu His Gly Gly Leu Glu Pro Leu Ile Arg Leu Leu Ser
 145                 150                 155                 160
 Ser Pro Asp Pro Asp Val Lys Lys Asn Ser Met Glu Cys Ile Tyr Asn
                 165                 170                 175    
 Leu Val Gln Asp Phe Gln Cys Arg Ala Lys Leu Gln Glu Leu Asn Ala
             180                 185                 190        
 Ile Pro Pro Ile Leu Asp Leu Leu Lys Ser Glu Tyr Pro Val Ile Gln
         195                 200                 205            
 Leu Leu Ala Leu Lys Thr Leu Gly Val Ile Ala Asn Asp Lys Glu Ser
     210                 215                 220                
 Arg Thr Met Leu Arg Asp Asn Gln Gly Leu Asp His Leu Ile Lys Ile
 225                 230                 235                 240
 Leu Glu Thr Lys Glu Leu Asn Asp Leu His Ile Glu Ala Leu Ala Val
                 245                 250                 255    
 Ile Ala Asn Cys Leu Glu Asp Met Asp Thr Met Val Gln Ile Gln Gln
             260                 265                 270        
 Thr Gly Gly Leu Lys Lys Leu Leu Ser Phe Ala Glu Asn Ser Thr Ile
         275                 280                 285            
 Pro Asp Ile Gln Lys Asn Ala Ala Lys Ala Ile Thr Lys Ala Ala Tyr
     290                 295                 300                
 Asp Pro Glu Asn Arg Lys Leu Phe His Glu Gln Glu Val Glu Lys Cys
 305                 310                 315                 320
 Leu Val Ala Leu Leu Gly Ser Glu Asn Asp Gly Thr Lys Ile Ala Ala
                 325                 330                 335    
 Ser Gln Ala Ile Ser Ala Met Cys Glu Asn Ser Gly Ser Lys Asp Phe
             340                 345                 350        
 Phe Asn Asn Gln Gly Ile Pro Gln Leu Ile Gln Leu Leu Lys Ser Asp
         355                 360                 365            
 Asn Glu Glu Val Arg Glu Ala Ala Ala Leu Ala Leu Ala Asn Leu Thr
     370                 375                 380                
 Thr Cys Asn Pro Ala Asn Ala Asn His Ser Asp Pro Gly Gly Val Arg
 385                 390                 395                 400
 His Thr Leu Gly Ile Gln Asp Cys Thr Gly Cys Trp Arg Arg Val Glu
                 405                 410                 415    
 Glu Arg Val Gly Trp Gly Glu Gly His Asn Leu Trp Cys Lys Pro Gln
             420                 425                 430        
 Asn Lys Lys Thr Leu Ser Leu Leu Leu Arg Ser Arg Phe Leu Glu Gly
         435                 440                 445            
 Leu His Val Leu Leu Leu Val Gly Gln Arg Arg Ala Leu Pro Ala Pro
     450                 455                 460                
 Asp Gly Ser Glu Lys Ala Gly Arg Gly Glu Gly Lys Gln Leu Arg Arg
 465                 470                 475                 480
 Arg Lys Gly Gln Lys Glu Thr Gly Glu Gly Gly Arg Lys Arg Glu Lys
                 485                 490                 495    
 Glu Glu Ser Arg Gly Val Glu Lys Arg Lys Arg Gly Gly Arg Gly Lys
             500                 505                 510        
 Gly Arg Leu Arg Phe Ala Gly Leu Gly Ser Ser Arg Asp Ser Gly Thr
         515                 520                 525            
 Pro Val Ser Phe Trp Thr Leu Cys Ala Ala Ala Glu Ala Asp Gly Ile
     530                 535                 540                
 Asp Pro Leu Ile Asn Leu Leu Ser Ser Lys Arg Asp Gly Ala Ile Ala
 545                 550                 555                 560
 Asn Ala Ala Thr Val Leu Thr Asn Met Ala Met Gln Glu Pro Leu Arg
                 565                 570                 575    
 Leu Asn Ile Gln Asn His Asp Ile Met His Ala Ile Ile Ser Pro Leu
             580                 585                 590        
 Arg Ser Ala Asn Thr Val Val Gln Ser Lys Ala Ala Leu Ala Val Thr
         595                 600                 605            
 Ala Thr Ala Cys Asp Val Glu Ala Arg Thr Glu Leu Arg Asn Ser Gly
     610                 615                 620                
 Gly Leu Glu Pro Leu Val Glu Leu Leu Arg Ser Lys Asn Asp Glu Val
 625                 630                 635                 640
 Arg Lys His Ala Ser Trp Ala Val Met Val Cys Ala Gly Asp Glu Leu
                 645                 650                 655    
 Thr Ala Asn Glu Leu Cys Arg Leu Gly Ala Leu Asp Ile Leu Glu Glu
             660                 665                 670        
 Val Asn Val Ser Gly Thr Arg Lys Asn Lys Phe Ser Glu Ala Ala Tyr
         675                 680                 685            
 Asn Lys Leu Leu Asn Asn Asn Leu Ser Leu Lys Tyr Ser Gln Thr Gly
     690                 695                 700                
 Tyr Leu Ser Ser Ser Asn Ile Ile Asn Asp Gly Phe Tyr Asp Tyr Gly
 705                 710                 715                 720
 Arg Ile Asn Pro Gly Thr Lys Leu Leu Pro Leu Lys Glu Leu Cys Leu
                 725                 730                 735    
 Gln Glu Pro Ser Asp Leu Arg Ala Val Leu Leu Ile Asn Ser Lys Ser
             740                 745                 750        
 Tyr Val Ser Pro Pro Ser Ser Met Glu Asp Lys Ser Asp Val Gly Tyr
         755                 760                 765            
 Gly Arg Ser Ile Ser Ser Ser Ser Ser Leu Arg Arg Ser Ser Lys Glu
     770                 775                 780                
 Lys Asn Lys Lys Asn Ser Tyr His Phe Ser Ala Gly Phe Gly Ser Pro
 785                 790                 795                 800
 Ile Glu Asp Lys Ser Glu Pro Ala Ser Gly Arg Asn Thr Val Leu Ser
                 805                 810                 815    
 Lys Ser Ala Thr Lys Glu Lys Gly Trp Arg Lys Ser Lys Gly Lys Lys
             820                 825                 830        
 Arg Arg Gly Lys Ser Glu Arg Gly Gly Arg Gly Tyr Gly Gly Thr Lys
         835                 840                 845            
 Ile Cys Trp
     850    



      <210> 583
      <211> 585
      <212> PRT
      <213> Homo sapiens


      <400> 583
 Met Asp Ala Leu Leu Gly Thr Gly Pro Arg Arg Ala Arg Gly Cys Leu
   1               5                  10                  15    
 Gly Ala Ala Gly Pro Thr Ser Ser Gly Arg Ala Ala Arg Thr Pro Ala
              20                  25                  30        
 Ala Pro Trp Ala Arg Phe Ser Ala Trp Leu Glu Cys Val Cys Val Val
          35                  40                  45            
 Thr Phe Asp Leu Glu Leu Gly Gln Ala Leu Glu Leu Val Tyr Pro Asn
      50                  55                  60                
 Asp Phe Pro Leu Thr Asp Glu Glu Lys Ser Ser Ile Cys Tyr Leu Ser
  65                  70                  75                  80
 Phe Pro Asp Ser His Ser Gly Cys Leu Gly Asp Thr Gln Phe Ser Phe
                  85                  90                  95    
 Arg Met Arg Gln Cys Gly Gly Gln Arg Ser Pro Trp His Ala Asp Asp
             100                 105                 110        
 Arg His Tyr Asn Ser Arg Ala Pro Val Ala Leu Gln Arg Glu Pro Ala
         115                 120                 125            
 His Tyr Phe Gly Tyr Val Tyr Phe Arg Gln Val Lys Asp Ser Ser Val
     130                 135                 140                
 Lys Arg Gly Tyr Phe Gln Lys Ser Leu Val Leu Val Ser Arg Leu Pro
 145                 150                 155                 160
 Phe Val Arg Leu Phe Gln Ala Leu Leu Ser Leu Ile Ala Pro Glu Tyr
                 165                 170                 175    
 Phe Asp Lys Leu Ala Pro Cys Leu Glu Ala Val Cys Ser Glu Ile Asp
             180                 185                 190        
 Gln Trp Pro Ala Pro Ala Pro Gly Gln Thr Leu Asn Leu Pro Val Met
         195                 200                 205            
 Gly Val Val Val Gln Val Arg Ile Pro Ser Arg Val Asp Lys Ser Glu
     210                 215                 220                
 Ser Ser Pro Pro Lys Gln Phe Asp Gln Glu Asn Leu Leu Pro Ala Pro
 225                 230                 235                 240
 Val Val Leu Ala Ser Val His Glu Leu Asp Leu Phe Arg Cys Phe Arg
                 245                 250                 255    
 Pro Val Leu Thr His Met Gln Thr Leu Trp Glu Leu Met Leu Leu Gly
             260                 265                 270        
 Glu Pro Leu Leu Val Leu Ala Pro Ser Pro Asp Val Ser Ser Glu Met
         275                 280                 285            
 Val Leu Ala Leu Thr Ser Cys Leu Gln Pro Leu Arg Phe Cys Cys Asp
     290                 295                 300                
 Phe Arg Pro Tyr Phe Thr Ile His Asp Ser Glu Phe Lys Glu Phe Thr
 305                 310                 315                 320
 Thr Arg Thr Gln Ala Pro Pro Asn Val Val Leu Gly Val Thr Asn Pro
                 325                 330                 335    
 Phe Phe Ile Lys Thr Leu Gln His Trp Pro His Ile Leu Arg Val Gly
             340                 345                 350        
 Glu Pro Lys Met Ser Gly Asp Leu Pro Lys Gln Val Lys Leu Lys Lys
         355                 360                 365            
 Pro Ser Arg Leu Lys Thr Leu Asp Thr Lys Pro Gly Leu Tyr Thr Ala
     370                 375                 380                
 Tyr Thr Ala His Leu His Arg Asp Lys Ala Leu Leu Lys Arg Leu Leu
 385                 390                 395                 400
 Lys Gly Val Gln Lys Lys Arg Pro Ser Asp Val Gln Ser Ala Leu Leu
                 405                 410                 415    
 Arg Arg His Leu Leu Glu Leu Thr Gln Ser Phe Ile Ile Pro Leu Glu
             420                 425                 430        
 His Tyr Met Ala Ser Leu Met Pro Leu Gln Lys Ser Ile Thr Pro Trp
         435                 440                 445            
 Lys Thr Pro Pro Gln Ile Gln Pro Phe Ser Gln Asp Asp Phe Leu Arg
     450                 455                 460                
 Ser Leu Glu His Ala Gly Pro Gln Leu Thr Cys Ile Leu Lys Gly Asp
 465                 470                 475                 480
 Trp Leu Gly Leu Tyr Arg Arg Phe Phe Lys Ser Pro His Phe Asp Gly
                 485                 490                 495    
 Trp Tyr Arg Gln Arg His Lys Glu Met Ala Leu Lys Leu Glu Ala Leu
             500                 505                 510        
 His Leu Glu Ala Ile Cys Glu Ala Asn Ile Glu Thr Trp Met Lys Asp
         515                 520                 525            
 Lys Ser Glu Val Glu Val Val Asp Leu Val Leu Lys Leu Arg Glu Lys
     530                 535                 540                
 Leu Val Arg Ala Gln Gly His Gln Leu Pro Val Lys Glu Ala Thr Leu
 545                 550                 555                 560
 Gln Arg Ala Gln Leu Tyr Ile Glu Thr Val Ile Gly Ser Leu Pro Lys
                 565                 570                 575    
 Asp Leu Gln Ala Val Leu Cys Pro Pro
             580                 585



      <210> 584
      <211> 211
      <212> PRT
      <213> Homo sapiens


      <400> 584
 Met Ala Ala Gly Gly Gly Gly Gly Ser Ser Lys Ala Ser Ser Ser Ser
   1               5                  10                  15    
 Ala Ser Ser Ala Gly Ala Leu Glu Ser Ser Leu Asp Arg Lys Phe Gln
              20                  25                  30        
 Ser Val Thr Asn Thr Met Glu Ser Ile Gln Gly Leu Ser Ser Trp Cys
          35                  40                  45            
 Ile Glu Asn Lys Lys His His Ser Thr Ile Val Tyr His Trp Met Lys
      50                  55                  60                
 Trp Leu Arg Arg Ser Ala Tyr Pro His Arg Leu Asn Leu Phe Tyr Leu
  65                  70                  75                  80
 Ala Asn Asp Val Ile Gln Asn Cys Lys Arg Lys Asn Ala Ile Ile Phe
                  85                  90                  95    
 Arg Glu Ser Phe Ala Asp Val Leu Pro Glu Ala Ala Ala Leu Val Lys
             100                 105                 110        
 Asp Pro Ser Val Ser Lys Ser Val Glu Arg Ile Phe Lys Ile Trp Glu
         115                 120                 125            
 Asp Arg Asn Val Tyr Pro Glu Glu Met Ile Val Ala Leu Arg Glu Ala
     130                 135                 140                
 Leu Thr Ser Thr Asn Pro Lys Ala Ala Leu Lys Ser Lys Ile Val Ala
 145                 150                 155                 160
 Glu Phe Arg Ala Leu Ile Glu Glu Leu Leu Leu Tyr Lys Arg Ser Glu
                 165                 170                 175    
 Asp Gln Ile Glu Leu Lys Glu Lys Gln Leu Ser Thr Met Arg Val Asp
             180                 185                 190        
 Val Cys Ser Thr Glu Thr Leu Lys Cys Leu Lys Gly Asn Ala Tyr Ile
         195                 200                 205            
 Leu Leu Glu
     210    



      <210> 585
      <211> 215
      <212> PRT
      <213> Homo sapiens


      <400> 585
 Met Ala Ser Val Ser Ser Trp Ser Arg Lys Met Ala Ala Ala Arg Pro
   1               5                  10                  15    
 Ser Leu Gly Arg Val Leu Pro Gly Ser Ser Val Leu Phe Leu Cys Asp
              20                  25                  30        
 Met Gln Glu Lys Phe Arg His Asn Ile Ala Tyr Phe Pro Gln Ile Val
          35                  40                  45            
 Ser Val Ala Ala Arg Met Leu Lys Val Ala Arg Leu Leu Glu Val Pro
      50                  55                  60                
 Val Met Leu Thr Glu Gln Tyr Pro Gln Gly Leu Gly Pro Thr Val Pro
  65                  70                  75                  80
 Glu Leu Gly Thr Glu Gly Leu Arg Pro Leu Ala Lys Thr Cys Phe Ser
                  85                  90                  95    
 Met Val Pro Ala Leu Gln Gln Glu Leu Asp Ser Arg Pro Gln Leu Arg
             100                 105                 110        
 Ser Val Leu Leu Cys Gly Ile Glu Ala Gln Ala Cys Ile Leu Asn Thr
         115                 120                 125            
 Thr Leu Asp Leu Leu Asp Arg Gly Leu Gln Val His Val Val Val Asp
     130                 135                 140                
 Ala Cys Ser Ser Arg Ser Gln Val Asp Arg Leu Val Ala Leu Ala Arg
 145                 150                 155                 160
 Met Arg Gln Ser Gly Ala Phe Leu Ser Thr Ser Glu Gly Leu Ile Leu
                 165                 170                 175    
 Gln Leu Val Gly Asp Ala Val His Pro Gln Phe Lys Glu Ile Gln Lys
             180                 185                 190        
 Leu Ile Lys Glu Pro Ala Pro Asp Ser Gly Leu Leu Gly Leu Phe Gln
         195                 200                 205            
 Gly Gln Asn Ser Leu Leu His
     210                 215



      <210> 586
      <211> 462
      <212> PRT
      <213> Homo sapiens


      <400> 586
 Met Ser Val Arg Phe Ser Ser Thr Ser Arg Arg Leu Gly Ser Cys Gly
   1               5                  10                  15    
 Gly Thr Gly Ser Val Arg Leu Ser Ser Gly Gly Ala Gly Phe Gly Ala
              20                  25                  30        
 Gly Asn Thr Cys Gly Val Pro Gly Ile Gly Ser Gly Phe Ser Cys Ala
          35                  40                  45            
 Phe Gly Gly Thr Ser Ser Ala Gly Gly Tyr Gly Gly Gly Leu Gly Gly
      50                  55                  60                
 Gly Ser Ala Ser Cys Ala Ala Phe Thr Gly Asn Glu His Gly Leu Leu
  65                  70                  75                  80
 Ser Gly Asn Glu Lys Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala
                  85                  90                  95    
 Ser Tyr Leu Glu Asn Val Arg Ala Leu Glu Glu Ala Asn Ala Asp Leu
             100                 105                 110        
 Glu Gln Lys Ile Lys Gly Trp Tyr Glu Lys Phe Gly Pro Gly Ser Cys
         115                 120                 125            
 Arg Gly Leu Asp His Asp Tyr Ser Arg Tyr Phe Pro Ile Ile Asp Lys
     130                 135                 140                
 Leu Lys Asn Gln Ile Ile Ser Ala Thr Thr Ser Asn Ala His Val Val
 145                 150                 155                 160
 Leu Gln Asn Asp Asn Ala Arg Leu Thr Ala Asp Asp Phe Arg Leu Lys
                 165                 170                 175    
 Phe Glu Asn Glu Leu Ala Leu His Gln Ser Val Glu Ala Asp Ile Asn
             180                 185                 190        
 Gly Leu Arg Arg Val Leu Asp Glu Leu Thr Leu Cys Arg Thr Asp Leu
         195                 200                 205            
 Glu Ile Gln Leu Glu Thr Leu Ser Glu Glu Leu Ala Tyr Leu Lys Lys
     210                 215                 220                
 Asn His Glu Glu Glu Met Lys Ala Leu Gln Cys Ala Ala Gly Gly Asn
 225                 230                 235                 240
 Val Asn Val Glu Met Asn Ala Ala Pro Gly Val Asp Leu Thr Val Leu
                 245                 250                 255    
 Leu Asn Asn Met Arg Ala Glu Tyr Glu Ala Leu Ala Glu Gln Asn Arg
             260                 265                 270        
 Arg Asp Ala Glu Ala Trp Phe Asn Glu Lys Ser Ala Ser Leu Gln Gln
         275                 280                 285            
 Gln Ile Ser Asp Asp Ala Gly Ala Thr Thr Ser Ala Arg Asn Glu Leu
     290                 295                 300                
 Ile Glu Met Lys Arg Thr Leu Gln Thr Leu Glu Ile Glu Leu Gln Ser
 305                 310                 315                 320
 Leu Leu Ala Thr Lys His Ser Leu Glu Cys Ser Leu Thr Glu Thr Glu
                 325                 330                 335    
 Ser Asn Tyr Cys Ala Gln Leu Ala Gln Ile Gln Ala Gln Ile Gly Ala
             340                 345                 350        
 Leu Glu Glu Gln Leu His Gln Val Arg Thr Glu Thr Glu Gly Gln Lys
         355                 360                 365            
 Leu Glu Tyr Glu Gln Leu Leu Asp Ile Lys Val His Leu Glu Lys Glu
     370                 375                 380                
 Ile Glu Thr Tyr Cys Leu Leu Ile Asp Gly Glu Asp Gly Ser Val Leu
 385                 390                 395                 400
 Pro Pro Leu Arg Lys Gln Phe Ile Phe Lys Phe Ile Cys Gly Ile Leu
                 405                 410                 415    
 Asp Ser Ser Lys Thr Thr Ile Val Lys Thr Val Val Glu Glu Ile Asp
             420                 425                 430        
 Pro Arg Gly Lys Val Leu Ser Ser Arg Val His Thr Val Glu Glu Lys
         435                 440                 445            
 Ser Thr Lys Val Asn Asn Lys Asn Glu Gln Arg Val Ser Ser
     450                 455                 460        



      <210> 587
      <211> 657
      <212> PRT
      <213> Homo sapiens


      <400> 587
 Met Ser Asp Gln Ala Gly Trp Arg Arg Arg Asp Arg Leu Ala Gly Ala
   1               5                  10                  15    
 Gly Pro Gly Glu Ala Gly Gly Ser Gln Ser Arg Ser Arg Ala Arg Ala
              20                  25                  30        
 Pro Gly Ala Asp Ala Thr Ala Met Ala Met Met Val Phe Pro Arg Glu
          35                  40                  45            
 Glu Lys Leu Ser Gln Asp Glu Ile Val Leu Gly Thr Lys Ala Val Ile
      50                  55                  60                
 Gln Gly Leu Glu Thr Leu Arg Gly Glu His Arg Ala Leu Leu Ala Pro
  65                  70                  75                  80
 Leu Val Ala Pro Glu Ala Gly Glu Ala Glu Pro Gly Ser Gln Glu Arg
                  85                  90                  95    
 Cys Ile Leu Leu Arg Arg Ser Leu Glu Ala Ile Glu Leu Gly Leu Gly
             100                 105                 110        
 Glu Ala Gln Val Ile Leu Ala Leu Ser Ser His Leu Gly Ala Val Glu
         115                 120                 125            
 Ser Glu Lys Gln Lys Leu Arg Ala Gln Val Arg Arg Leu Val Gln Glu
     130                 135                 140                
 Asn Gln Trp Leu Arg Glu Glu Leu Ala Gly Thr Gln Gln Lys Leu Gln
 145                 150                 155                 160
 Arg Ser Glu Gln Ala Val Ala Gln Leu Glu Glu Glu Lys Gln His Leu
                 165                 170                 175    
 Leu Phe Met Ser Gln Ile Arg Lys Leu Asp Glu Asp Ala Ser Pro Asn
             180                 185                 190        
 Glu Glu Lys Gly Asp Val Pro Lys Asp Thr Leu Asp Asp Leu Phe Pro
         195                 200                 205            
 Asn Glu Asp Glu Gln Ser Pro Gly Gly Gly Asp Val Ser Gly Gln His
     210                 215                 220                
 Gly Gly Tyr Glu Ile Pro Ala Arg Leu Arg Thr Leu His Asn Leu Val
 225                 230                 235                 240
 Ile Gln Tyr Ala Ser Gln Gly Arg Tyr Glu Val Ala Ala Pro Leu Cys
                 245                 250                 255    
 Lys Gln Ala Leu Glu Asp Leu Glu Lys Thr Ser Gly His Asp His Pro
             260                 265                 270        
 Asp Val Ala Thr Met Leu Asn Ile Leu Ala Leu Val Tyr Arg Asp Gln
         275                 280                 285            
 Asn Lys Tyr Lys Glu Ala Ala His Leu Leu Asn Asp Ala Leu Ala Ile
     290                 295                 300                
 Arg Glu Lys Thr Leu Gly Lys Asp His Pro Ala Val Ala Ala Thr Leu
 305                 310                 315                 320
 Asn Asn Leu Ala Val Leu Tyr Gly Lys Arg Gly Lys Tyr Lys Glu Ala
                 325                 330                 335    
 Glu Pro Leu Cys Lys Arg Ala Leu Glu Ile Arg Glu Lys Val Leu Gly
             340                 345                 350        
 Lys Phe His Pro Asp Val Ala Lys Gln Leu Ser Asn Leu Ala Leu Leu
         355                 360                 365            
 Cys Gln Asn Gln Gly Lys Ala Glu Glu Val Glu Tyr Tyr Tyr Arg Arg
     370                 375                 380                
 Ala Leu Glu Ile Tyr Ala Thr Arg Leu Gly Pro Asp Asp Pro Asn Val
 385                 390                 395                 400
 Ala Lys Thr Lys Asn Asn Leu Ala Ser Cys Tyr Leu Lys Gln Gly Lys
                 405                 410                 415    
 Tyr Gln Asp Ala Glu Thr Leu Tyr Lys Glu Ile Leu Thr Arg Ala His
             420                 425                 430        
 Glu Lys Glu Phe Gly Ser Val Asn Gly Asp Asn Lys Pro Ile Trp Met
         435                 440                 445            
 His Ala Glu Glu Arg Glu Glu Ser Lys Asp Lys Arg Arg Asp Ser Ala
     450                 455                 460                
 Pro Tyr Gly Glu Tyr Gly Ser Trp Tyr Lys Ala Cys Lys Val Asp Ser
 465                 470                 475                 480
 Pro Thr Val Asn Thr Thr Leu Arg Ser Leu Gly Ala Leu Tyr Arg Arg
                 485                 490                 495    
 Gln Gly Lys Leu Glu Ala Ala His Thr Leu Glu Asp Cys Ala Ser Arg
             500                 505                 510        
 Asn Arg Lys Gln Gly Leu Asp Pro Ala Ser Gln Thr Lys Val Val Glu
         515                 520                 525            
 Leu Leu Lys Asp Gly Ser Gly Arg Arg Gly Asp Arg Arg Ser Ser Arg
     530                 535                 540                
 Asp Met Ala Gly Gly Ala Gly Pro Arg Ser Glu Ser Asp Leu Glu Asp
 545                 550                 555                 560
 Val Gly Pro Thr Ala Glu Trp Asn Gly Asp Gly Ser Gly Ser Leu Arg
                 565                 570                 575    
 Arg Ser Gly Ser Phe Gly Lys Leu Arg Asp Ala Leu Arg Arg Ser Ser
             580                 585                 590        
 Glu Met Leu Val Lys Lys Leu Gln Gly Gly Thr Pro Gln Glu Pro Pro
         595                 600                 605            
 Asn Pro Arg Met Lys Arg Ala Ser Ser Leu Asn Phe Leu Asn Lys Ser
     610                 615                 620                
 Val Glu Glu Pro Thr Gln Pro Gly Gly Thr Gly Leu Ser Asp Ser Arg
 625                 630                 635                 640
 Thr Leu Ser Ser Ser Ser Met Asp Leu Ser Arg Arg Ser Ser Leu Val
                 645                 650                 655    
 Gly
    



      <210> 588
      <211> 271
      <212> PRT
      <213> Homo sapiens


      <400> 588
 Met Ala Pro Ser Arg Asn Gly Met Val Leu Lys Pro His Phe His Lys
   1               5                  10                  15    
 Asp Trp Gln Arg Arg Val Ala Thr Trp Phe Asn Gln Pro Ala Arg Lys
              20                  25                  30        
 Ile Arg Arg Arg Lys Ala Arg Gln Ala Lys Ala Arg Arg Ile Ala Pro
          35                  40                  45            
 Arg Pro Ala Ser Gly Pro Ile Arg Pro Ile Val Arg Cys Pro Thr Val
      50                  55                  60                
 Arg Tyr His Thr Lys Val Arg Ala Gly Arg Gly Phe Ser Leu Glu Glu
  65                  70                  75                  80
 Leu Arg Val Ala Gly Ile His Lys Lys Val Ala Arg Thr Ile Gly Ile
                  85                  90                  95    
 Ser Val Asp Pro Arg Arg Arg Asn Lys Ser Thr Glu Ser Leu Gln Ala
             100                 105                 110        
 Asn Val Gln Arg Leu Lys Glu Tyr Arg Ser Lys Leu Ile Leu Phe Pro
         115                 120                 125            
 Arg Lys Pro Ser Ala Pro Lys Lys Gly Asp Ser Ser Ala Glu Glu Leu
     130                 135                 140                
 Lys Leu Ala Thr Gln Leu Thr Gly Pro Val Met Pro Val Arg Asn Val
 145                 150                 155                 160
 Tyr Lys Lys Glu Lys Ala Arg Val Ile Thr Glu Glu Glu Lys Asn Phe
                 165                 170                 175    
 Lys Ala Phe Ala Ser Leu Arg Met Ala Arg Ala Asn Ala Arg Leu Phe
             180                 185                 190        
 Gly Ile Arg Ala Lys Arg Ala Lys Glu Ala Ala Glu Gln Asp Val Glu
         195                 200                 205            
 Lys Lys Lys Lys Ser Pro Pro Gly Asp Leu Glu Ser Ser Arg Gln Ser
     210                 215                 220                
 Cys Trp Val Ser Thr Trp Cys Val Ser Trp Glu Gln Leu Gly Leu Gly
 225                 230                 235                 240
 Trp Gly Phe Thr Ala Val Thr Ser Ser Cys Gln Gly Ile Trp Gly Phe
                 245                 250                 255    
 Leu Glu Arg Gln Ser Lys Pro Trp Ile Met Leu Tyr Phe Leu Cys
             260                 265                 270    



      <210> 589
      <211> 553
      <212> PRT
      <213> Homo sapiens


      <400> 589
 Met Leu Lys Thr Tyr Lys Ser Phe Phe Lys Gln Asn Ile Ile Pro Val
   1               5                  10                  15    
 Asn Leu Asp Gln Tyr Val Pro Lys Val Glu Leu Lys Glu Tyr Leu Lys
              20                  25                  30        
 Ile Asn Asp Thr Ile Tyr Glu Val Asp Ser Lys Ala Glu Asn Gly Met
          35                  40                  45            
 Thr Phe Ser Arg Leu Leu Asn Tyr Lys Tyr Ser Asp Thr Leu Lys Lys
      50                  55                  60                
 Met Asp Pro Asp His Leu Val Ala Leu Val Thr Glu Val Ile Pro Asn
  65                  70                  75                  80
 Tyr Ser Cys Leu Val Phe Cys Pro Ser Lys Lys Asn Cys Glu Asn Val
                  85                  90                  95    
 Ala Glu Met Ile Cys Lys Phe Leu Ser Lys Glu Tyr Leu Lys His Lys
             100                 105                 110        
 Glu Lys Glu Lys Cys Glu Val Ile Lys Asn Leu Lys Asn Ile Gly Asn
         115                 120                 125            
 Gly Asn Leu Cys Pro Val Leu Lys Arg Thr Ile Pro Phe Gly Val Ala
     130                 135                 140                
 Tyr His His Ser Gly Leu Thr Ser Asp Glu Arg Lys Leu Leu Glu Glu
 145                 150                 155                 160
 Ala Tyr Ser Thr Gly Val Leu Cys Leu Phe Thr Cys Thr Ser Thr Leu
                 165                 170                 175    
 Ala Ala Gly Val Asn Leu Pro Ala Arg Arg Val Ile Leu Arg Ala Pro
             180                 185                 190        
 Tyr Val Ala Lys Glu Phe Leu Lys Arg Asn Gln Tyr Lys Gln Met Ile
         195                 200                 205            
 Gly Arg Ala Gly Arg Ala Gly Ile Asp Thr Ile Gly Glu Ser Ile Leu
     210                 215                 220                
 Ile Leu Gln Glu Lys Asp Lys Gln Gln Val Leu Glu Leu Ile Thr Lys
 225                 230                 235                 240
 Pro Leu Glu Asn Cys Tyr Ser His Leu Val Gln Glu Phe Thr Lys Gly
                 245                 250                 255    
 Ile Gln Thr Leu Phe Leu Ser Leu Ile Gly Leu Lys Ile Ala Thr Asn
             260                 265                 270        
 Leu Asp Asp Ile Tyr His Phe Met Asn Gly Thr Phe Phe Gly Val Gln
         275                 280                 285            
 Gln Lys Val Leu Leu Lys Glu Lys Ser Leu Trp Glu Ile Thr Val Glu
     290                 295                 300                
 Ser Leu Arg Tyr Leu Thr Glu Lys Gly Leu Leu Gln Lys Asp Thr Ile
 305                 310                 315                 320
 Tyr Lys Ser Glu Glu Glu Val Gln Tyr Asn Phe His Ile Thr Lys Leu
                 325                 330                 335    
 Gly Arg Ala Ser Phe Lys Gly Thr Ile Asp Leu Ala Tyr Cys Asp Ile
             340                 345                 350        
 Leu Tyr Arg Asp Leu Lys Lys Gly Leu Glu Gly Leu Val Leu Glu Ser
         355                 360                 365            
 Leu Leu His Leu Ile Tyr Leu Thr Thr Pro Tyr Asp Leu Val Ser Gln
     370                 375                 380                
 Cys Asn Pro Asp Trp Met Ile Tyr Phe Arg Gln Phe Ser Gln Leu Ser
 385                 390                 395                 400
 Pro Ala Glu Gln Asn Val Ala Ala Ile Leu Gly Val Ser Glu Ser Phe
                 405                 410                 415    
 Ile Gly Lys Lys Ala Ser Gly Gln Ala Ile Gly Lys Lys Val Asp Lys
             420                 425                 430        
 Asn Val Val Asn Arg Leu Tyr Leu Ser Phe Val Leu Tyr Thr Leu Leu
         435                 440                 445            
 Lys Glu Thr Asn Ile Trp Thr Val Ser Glu Lys Phe Asn Met Pro Arg
     450                 455                 460                
 Gly Tyr Ile Gln Asn Leu Leu Thr Gly Thr Ala Ser Phe Ser Ser Cys
 465                 470                 475                 480
 Val Leu His Phe Cys Glu Glu Leu Glu Glu Phe Trp Val Tyr Arg Ala
                 485                 490                 495    
 Leu Leu Val Glu Leu Thr Lys Lys Leu Thr Tyr Cys Val Lys Ala Glu
             500                 505                 510        
 Leu Ile Pro Leu Met Glu Val Thr Gly Val Leu Glu Gly Arg Ala Lys
         515                 520                 525            
 Gln Leu Tyr Ser Ala Gly Tyr Lys Ser Leu Met His Leu Ala Asn Ala
     530                 535                 540                
 Asn Pro Ala Ser Ala Arg Lys Asp Asn
 545                 550            



      <210> 590
      <211> 192
      <212> PRT
      <213> Homo sapiens


      <400> 590
 Met Gly Arg Val Ile Arg Gly Gln Arg Lys Gly Ala Gly Ser Val Phe
   1               5                  10                  15    
 Arg Ala His Val Lys His Arg Lys Gly Ala Ala Arg Leu Arg Ala Val
              20                  25                  30        
 Asp Phe Ala Glu Arg His Gly Tyr Ile Lys Gly Ile Val Lys Asp Ile
          35                  40                  45            
 Ile His Asp Pro Gly Arg Gly Ala Pro Leu Ala Lys Val Val Phe Arg
      50                  55                  60                
 Asp Pro Tyr Arg Phe Lys Lys Arg Thr Glu Leu Phe Ile Ala Ala Glu
  65                  70                  75                  80
 Gly Ile His Thr Gly Gln Phe Val Tyr Cys Gly Lys Lys Ala Gln Leu
                  85                  90                  95    
 Asn Ile Gly Asn Val Leu Pro Val Gly Thr Met Pro Glu Gly Thr Ile
             100                 105                 110        
 Val Cys Cys Leu Glu Glu Lys Pro Gly Asp Arg Gly Lys Leu Ala Arg
         115                 120                 125            
 Ala Ser Gly Asn Tyr Ala Thr Val Ile Ser His Asn Pro Val Glu His
     130                 135                 140                
 Pro Phe Gly Gly Gly Asn His Gln His Ile Gly Lys Pro Ser Thr Ile
 145                 150                 155                 160
 Arg Arg Asp Ala Pro Ala Gly Arg Lys Val Gly Leu Ile Ala Ala Arg
                 165                 170                 175    
 Arg Thr Gly Arg Leu Arg Gly Thr Lys Thr Val Gln Glu Lys Glu Asn
             180                 185                 190        





      <210> 591
      <211> 118
      <212> PRT
      <213> Homo sapiens


      <400> 591
 Met Thr Ser Arg Ser Gly Arg Lys Arg Gln Ala Ala Leu Glu Val Thr
   1               5                  10                  15    
 Ala Arg Tyr Cys Gly Arg Glu Leu Glu Gln Tyr Gly Gln Cys Val Ala
              20                  25                  30        
 Ala Lys Pro Glu Ser Trp Gln Arg Asp Cys His Tyr Leu Lys Met Ser
          35                  40                  45            
 Ile Ala Gln Cys Thr Ser Ser His Pro Ile Ile Arg Gln Ile Arg Gln
      50                  55                  60                
 Ala Cys Ala Gln Pro Phe Glu Ala Phe Glu Glu Cys Leu Arg Gln Asn
  65                  70                  75                  80
 Glu Ala Ala Val Gly Asn Cys Ala Glu His Met Arg Arg Phe Leu Gln
                  85                  90                  95    
 Cys Ala Glu Gln Val Gln Pro Pro Arg Ser Pro Ala Thr Val Glu Ala
             100                 105                 110        
 Gln Pro Leu Pro Ala Ser
         115            



      <210> 592
      <211> 259
      <212> PRT
      <213> Homo sapiens


      <400> 592
 Met Asn Gln Glu Ala Ile Gly Asn Gln Gln Lys Ser Thr Ala Asn Leu
   1               5                  10                  15    
 His Asn Lys Arg Lys Ser His Leu Val Gly Ile Cys Gly Gly Gly Cys
              20                  25                  30        
 Leu Asp Leu Lys Leu Tyr Pro Ile Ile Cys Pro Ile Ser Ser Glu Asn
          35                  40                  45            
 Gln Arg Lys Thr Phe Leu Glu Gln Thr Val Tyr Cys Thr Arg Ile Asp
      50                  55                  60                
 Leu Gln Gln Lys Leu Val Phe Leu Arg Leu Glu Ala Phe Cys Leu Leu
  65                  70                  75                  80
 Ser Gln Gly Asp Pro Gly Ser Pro Met Met Cys Gln Leu Gln Gln Phe
                  85                  90                  95    
 Asp Leu Trp Val Leu Arg Gly Val Leu Asn Phe Gly Gly Glu Thr Cys
             100                 105                 110        
 Pro Gly Leu Phe Leu Tyr Thr Lys Val Glu Asp Tyr Ser Lys Trp Ile
         115                 120                 125            
 Thr Ser Lys Ala Glu Arg Ala Gly Pro Pro Leu Ser Ser Leu His His
     130                 135                 140                
 Trp Glu Lys Leu Ile Ser Phe Ser His His Gly Pro Asn Ala Thr Met
 145                 150                 155                 160
 Thr Gln Lys Thr Tyr Ser Asp Ser Glu Leu Gly His Val Gly Ser Tyr
                 165                 170                 175    
 Leu Gln Gly Gln Arg Arg Thr Ile Thr His Ser Arg Leu Gly Asn Ser
             180                 185                 190        
 Ser Arg Asp Ser Leu Asp Val Arg Glu Lys Asp Val Lys Glu Ser Gly
         195                 200                 205            
 Arg Ser Pro Glu Ala Ser Val Gln Pro Leu Tyr Tyr Asp Tyr Tyr Gly
     210                 215                 220                
 Gly Glu Val Gly Glu Gly Arg Ile Phe Ala Gly Gln Asn Arg Leu Tyr
 225                 230                 235                 240
 Gln Pro Glu Glu Ile Ile Leu Val Ser Phe Val Leu Val Phe Phe Cys
                 245                 250                 255    
 Ser Ser Ile
            



      <210> 593
      <211> 1032
      <212> PRT
      <213> Homo sapiens


      <400> 593
 Met Glu Ala Ala Ala Ala Val Val Ala Ala Glu Ala Glu Val Glu Asn
   1               5                  10                  15    
 Glu Asp Gly Asp Ser Ser Cys Gly Asp Val Cys Phe Met Asp Lys Gly
              20                  25                  30        
 Leu Gln Ser Ile Ser Glu Leu Ser Leu Asp Ser Thr Leu His Ala Val
          35                  40                  45            
 Asn Leu His Cys Asn Asn Ile Ser Lys Ile Glu Ala Ile Asp His Ile
      50                  55                  60                
 Trp Asn Leu Gln His Leu Asp Leu Ser Ser Asn Gln Ile Ser Arg Ile
  65                  70                  75                  80
 Glu Gly Leu Asn Thr Leu Thr Lys Leu Cys Thr Leu Asn Leu Ser Cys
                  85                  90                  95    
 Asn Leu Ile Thr Lys Val Glu Gly Leu Glu Glu Leu Ile Asn Leu Thr
             100                 105                 110        
 Arg Leu Asn Val Ser Tyr Asn His Ile Asp Asp Leu Ser Gly Leu Ile
         115                 120                 125            
 Pro Leu His Gly Ile Lys His Lys Leu Arg Tyr Ile Asp Leu His Ser
     130                 135                 140                
 Asn Arg Ile Asp Ser Ile His His Leu Leu Gln Cys Met Val Gly Leu
 145                 150                 155                 160
 His Phe Leu Thr Asn Leu Ile Leu Glu Lys Asp Gly Asp Asp Asn Pro
                 165                 170                 175    
 Val Cys Arg Leu Pro Gly Tyr Arg Ala Val Ile Leu Gln Thr Leu Pro
             180                 185                 190        
 Gln Leu Arg Ile Leu Asp Cys Lys Asn Ile Phe Gly Glu Pro Val Asn
         195                 200                 205            
 Leu Thr Glu Ile Asn Ser Ser Gln Leu Gln Cys Leu Glu Gly Leu Leu
     210                 215                 220                
 Asp Asn Leu Val Ser Ser Asp Ser Pro Leu Asn Ile Ser Glu Asp Glu
 225                 230                 235                 240
 Ile Ile Asp Arg Met Pro Val Ile Thr Ala Pro Ile Asp Glu Leu Val
                 245                 250                 255    
 Pro Leu Glu Gln Phe Ala Ser Thr Pro Ser Asp Ala Val Leu Thr Ser
             260                 265                 270        
 Phe Met Ser Val Cys Gln Ser Ser Glu Pro Glu Lys Asn Asn His Glu
         275                 280                 285            
 Asn Asp Leu Gln Asn Glu Ile Lys Leu Gln Lys Leu Asp Asp Gln Ile
     290                 295                 300                
 Leu Gln Leu Leu Asn Glu Thr Ser Asn Ser Ile Asp Asn Val Leu Glu
 305                 310                 315                 320
 Lys Asp Pro Arg Pro Lys Arg Asp Thr Asp Ile Thr Ser Glu Ser Asp
                 325                 330                 335    
 Tyr Gly Asn Arg Lys Glu Cys Asn Arg Lys Val Pro Arg Arg Ser Lys
             340                 345                 350        
 Ile Pro Tyr Asp Ala Lys Thr Ile Gln Thr Ile Lys His His Asn Lys
         355                 360                 365            
 Asn Tyr Asn Ser Phe Val Ser Cys Asn Arg Lys Met Lys Pro Pro Tyr
     370                 375                 380                
 Leu Lys Glu Leu Tyr Val Ser Ser Ser Leu Ala Asn Cys Pro Met Leu
 385                 390                 395                 400
 Gln Glu Ser Glu Lys Pro Lys Thr Glu Ile Ile Lys Val Asp Gln Ser
                 405                 410                 415    
 His Ser Glu Asp Asn Thr Tyr Gln Ser Leu Val Glu Gln Leu Asp Gln
             420                 425                 430        
 Glu Arg Glu Lys Arg Trp Arg Ala Glu Gln Ala Glu Asn Lys Leu Met
         435                 440                 445            
 Asp Tyr Ile Asp Glu Leu His Lys His Ala Asn Glu Lys Glu Asp Ile
     450                 455                 460                
 His Ser Leu Ala Leu Leu Thr Thr Asp Arg Leu Lys Glu Ile Ile Phe
 465                 470                 475                 480
 Arg Glu Arg Asn Ser Lys Gly Gln Leu Glu Val Met Val His Lys Leu
                 485                 490                 495    
 Gln Asn Glu Ile Lys Lys Leu Thr Val Glu Leu Met Lys Ala Lys Asp
             500                 505                 510        
 Gln Gln Glu Asp His Leu Lys His Leu Arg Thr Leu Glu Lys Thr Leu
         515                 520                 525            
 Glu Lys Met Glu Arg Gln Lys Arg Gln Gln Gln Ala Ala Gln Ile Arg
     530                 535                 540                
 Leu Ile Gln Glu Val Glu Leu Lys Ala Ser Ala Ala Asp Arg Glu Ile
 545                 550                 555                 560
 Tyr Leu Leu Arg Thr Ser Leu His Arg Glu Arg Glu Gln Ala Gln Gln
                 565                 570                 575    
 Leu His Gln Leu Leu Ala Leu Lys Glu Gln Glu His Arg Lys Glu Leu
             580                 585                 590        
 Glu Thr Arg Glu Phe Phe Thr Asp Ala Asp Phe Gln Asp Ala Leu Ala
         595                 600                 605            
 Lys Glu Ile Ala Lys Glu Glu Lys Lys His Glu Gln Met Ile Lys Glu
     610                 615                 620                
 Tyr Gln Glu Lys Ile Asp Val Leu Ser Gln Gln Tyr Met Asp Leu Glu
 625                 630                 635                 640
 Asn Glu Phe Arg Ile Ala Leu Thr Val Glu Ala Arg Arg Phe Gln Asp
                 645                 650                 655    
 Val Lys Asp Gly Phe Glu Asn Val Ala Thr Glu Leu Ala Lys Ser Lys
             660                 665                 670        
 His Ala Leu Ile Trp Ala Gln Arg Lys Glu Asn Glu Ser Ser Ser Leu
         675                 680                 685            
 Ile Lys Asp Leu Thr Cys Met Val Lys Glu Gln Lys Thr Lys Leu Ala
     690                 695                 700                
 Glu Val Ser Lys Leu Lys Gln Glu Thr Ala Ala Asn Leu Gln Asn Gln
 705                 710                 715                 720
 Ile Asn Thr Leu Glu Ile Leu Ile Glu Asp Asp Lys Gln Lys Ser Ile
                 725                 730                 735    
 Gln Ile Glu Leu Leu Lys His Glu Lys Val Gln Leu Ile Ser Glu Leu
             740                 745                 750        
 Ala Ala Lys Glu Ser Leu Ile Phe Gly Leu Arg Thr Glu Arg Lys Val
         755                 760                 765            
 Trp Gly His Glu Leu Ala Gln Gln Gly Ser Ser Leu Ala Gln Asn Arg
     770                 775                 780                
 Gly Lys Leu Glu Ala Gln Ile Glu Ser Leu Ser Arg Glu Asn Glu Cys
 785                 790                 795                 800
 Leu Arg Lys Thr Asn Glu Ser Asp Ser Asp Ala Leu Arg Ile Lys Cys
                 805                 810                 815    
 Lys Ile Ile Asp Asp Gln Thr Glu Thr Ile Arg Lys Leu Lys Asp Cys
             820                 825                 830        
 Leu Gln Glu Lys Asp Glu His Ile Lys Arg Leu Gln Glu Lys Ile Thr
         835                 840                 845            
 Glu Ile Glu Lys Cys Thr Gln Glu Gln Leu Asp Glu Lys Ser Ser Gln
     850                 855                 860                
 Leu Asp Glu Val Leu Glu Lys Leu Glu Arg His Asn Glu Arg Lys Glu
 865                 870                 875                 880
 Lys Leu Lys Gln Gln Leu Lys Gly Lys Glu Val Glu Leu Glu Glu Ile
                 885                 890                 895    
 Arg Lys Ala Tyr Ser Thr Leu Asn Arg Lys Trp His Asp Lys Gly Glu
             900                 905                 910        
 Leu Leu Cys His Leu Glu Thr Gln Val Lys Glu Val Lys Glu Lys Phe
         915                 920                 925            
 Glu Asn Lys Glu Lys Lys Leu Lys Ala Glu Arg Asp Lys Ser Ile Glu
     930                 935                 940                
 Leu Gln Lys Asn Ala Met Glu Lys Leu His Ser Met Asp Asp Ala Phe
 945                 950                 955                 960
 Lys Arg Gln Val Asp Ala Ile Val Glu Ala His Gln Ala Glu Ile Ala
                 965                 970                 975    
 Gln Leu Ala Asn Glu Lys Gln Lys Cys Ile Asp Ser Ala Asn Leu Lys
             980                 985                 990        
 Val His Gln Ile Glu Lys Glu Met Arg Glu Leu Leu Glu Glu Thr Cys
         995                1000                1005            
 Lys Asn Lys Lys Thr Met Glu Ala Lys Ile Lys Gln Leu Ala Phe Ala
    1010                1015                1020                
 Leu Asn Glu Ile Gln Gln Asp Met
1025                1030        



      <210> 594
      <211> 1144
      <212> PRT
      <213> Homo sapiens


      <400> 594
 Met Trp Arg Gly Pro Asn Val Asn Cys Val Asp Ser Thr Gly Tyr Thr
   1               5                  10                  15    
 Pro Leu His His Ala Ala Leu Asn Gly His Lys Asp Val Val Glu Val
              20                  25                  30        
 Leu Leu Arg Asn Asp Ala Leu Thr Asn Val Ala Asp Ser Lys Gly Cys
          35                  40                  45            
 Tyr Pro Leu His Leu Ala Ala Trp Lys Gly Asp Ala Gln Ile Val Arg
      50                  55                  60                
 Leu Leu Ile His Gln Gly Pro Ser His Thr Arg Val Asn Glu Gln Asn
  65                  70                  75                  80
 Asn Asp Asn Glu Thr Ala Leu His Cys Ala Ala Gln Tyr Gly His Thr
                  85                  90                  95    
 Glu Val Val Lys Val Leu Leu Glu Glu Leu Thr Asp Pro Thr Met Arg
             100                 105                 110        
 Asn Asn Lys Phe Glu Thr Pro Leu Asp Leu Ala Ala Leu Tyr Gly Arg
         115                 120                 125            
 Leu Glu Val Val Lys Met Leu Leu Asn Ala His Pro Asn Leu Leu Ser
     130                 135                 140                
 Cys Asn Thr Lys Lys His Thr Pro Leu His Leu Ala Ala Arg Asn Gly
 145                 150                 155                 160
 His Lys Ala Val Val Gln Val Leu Leu Asp Ala Gly Met Asp Ser Asn
                 165                 170                 175    
 Tyr Gln Thr Glu Met Gly Ser Ala Leu His Glu Ala Ala Leu Phe Gly
             180                 185                 190        
 Lys Thr Asp Val Val Gln Ile Leu Leu Ala Ala Gly Thr Asp Val Asn
         195                 200                 205            
 Ile Lys Asp Asn His Gly Leu Thr Ala Leu Asp Thr Val Arg Glu Leu
     210                 215                 220                
 Pro Ser Gln Lys Ser Gln Gln Ile Ala Ala Leu Ile Glu Asp His Met
 225                 230                 235                 240
 Thr Gly Lys Arg Ser Thr Lys Glu Val Asp Lys Thr Pro Pro Pro Gln
                 245                 250                 255    
 Pro Pro Leu Ile Ser Ser Met Asp Ser Ile Ser Gln Lys Ser Gln Gly
             260                 265                 270        
 Asp Val Glu Lys Ala Val Thr Glu Leu Ile Ile Asp Phe Asp Ala Asn
         275                 280                 285            
 Ala Glu Glu Glu Gly Pro Tyr Glu Ala Leu Tyr Asn Ala Ile Ser Cys
     290                 295                 300                
 His Ser Leu Asp Ser Met Ala Ser Gly Arg Ser Ser Asp Gln Asp Ser
 305                 310                 315                 320
 Thr Asn Lys Glu Ala Glu Ala Ala Gly Val Lys Pro Ala Gly Val Arg
                 325                 330                 335    
 Pro Arg Glu Arg Pro Pro Pro Pro Ala Lys Pro Pro Pro Asp Glu Glu
             340                 345                 350        
 Glu Glu Asp His Ile Asp Lys Lys Tyr Phe Pro Leu Thr Ala Ser Glu
         355                 360                 365            
 Val Leu Ser Met Arg Pro Arg Ile His Gly Ser Ala Ala Arg Glu Glu
     370                 375                 380                
 Asp Glu His Pro Tyr Glu Leu Leu Leu Thr Ala Glu Thr Lys Lys Val
 385                 390                 395                 400
 Val Leu Val Asp Gly Lys Thr Lys Asp His Arg Arg Ser Ser Ser Ser
                 405                 410                 415    
 Arg Ser Gln Asp Ser Ala Glu Gly Gln Asp Gly Gln Val Pro Glu Gln
             420                 425                 430        
 Phe Ser Gly Leu Leu His Gly Ser Ser Pro Val Cys Glu Val Gly Gln
         435                 440                 445            
 Asp Pro Phe Gln Leu Leu Cys Thr Ala Gly Gln Ser His Pro Asp Gly
     450                 455                 460                
 Ser Pro Gln Gln Gly Ala Cys His Lys Ala Ser Met Gln Leu Glu Glu
 465                 470                 475                 480
 Thr Gly Val His Ala Pro Gly Ala Ser Gln Pro Ser Ala Leu Asp Gln
                 485                 490                 495    
 Ser Lys Arg Val Gly Tyr Leu Thr Gly Leu Pro Thr Thr Asn Ser Arg
             500                 505                 510        
 Ser His Pro Glu Thr Leu Thr His Thr Ala Ser Pro His Pro Gly Gly
         515                 520                 525            
 Ala Glu Glu Gly Asp Arg Ser Gly Ala Arg Ser Arg Ala Pro Pro Thr
     530                 535                 540                
 Ser Lys Pro Lys Ala Glu Leu Lys Leu Ser Arg Ser Leu Ser Lys Ser
 545                 550                 555                 560
 Asp Ser Asp Leu Leu Thr Cys Ser Pro Thr Glu Asp Ala Thr Met Gly
                 565                 570                 575    
 Ser Arg Ser Glu Ser Leu Ser Asn Cys Ser Ile Gly Lys Lys Arg Leu
             580                 585                 590        
 Glu Lys Ser Pro Ser Phe Ala Ser Glu Trp Asp Glu Ile Glu Lys Ile
         595                 600                 605            
 Met Ser Ser Ile Gly Glu Gly Ile Asp Phe Ser Gln Glu Arg Gln Lys
     610                 615                 620                
 Ile Ser Gly Ser Arg Thr Leu Glu Gln Ser Val Gly Glu Trp Leu Glu
 625                 630                 635                 640
 Ser Ile Gly Leu Gln Gln Tyr Glu Ser Lys Leu Leu Leu Asn Gly Phe
                 645                 650                 655    
 Asp Asp Val His Phe Leu Gly Ser Asn Val Met Glu Glu Gln Asp Leu
             660                 665                 670        
 Arg Asp Ile Gly Ile Ser Asp Pro Gln His Arg Arg Lys Leu Leu Gln
         675                 680                 685            
 Ala Ala Arg Ser Leu Pro Lys Val Lys Ala Leu Gly Tyr Asp Gly Asn
     690                 695                 700                
 Ser Pro Pro Ser Val Pro Ser Trp Leu Asp Ser Leu Gly Leu Gln Asp
 705                 710                 715                 720
 Tyr Val His Ser Phe Leu Ser Ser Gly Tyr Ser Ser Ile Asp Thr Val
                 725                 730                 735    
 Lys Asn Leu Trp Glu Leu Glu Leu Val Asn Val Leu Lys Val Gln Leu
             740                 745                 750        
 Leu Gly His Arg Lys Arg Ile Ile Ala Ser Leu Ala Asp Arg Pro Tyr
         755                 760                 765            
 Glu Glu Pro Pro Gln Lys Pro Pro Arg Phe Ser Gln Leu Arg Cys Gln
     770                 775                 780                
 Asp Leu Leu Ser Gln Thr Ser Ser Pro Leu Ser Gln Asn Asp Ser Cys
 785                 790                 795                 800
 Thr Gly Arg Ser Ala Asp Leu Leu Leu Pro Pro Gly Asp Thr Gly Arg
                 805                 810                 815    
 Arg Arg His Asp Ser Leu His Asp Pro Ala Ala Pro Ser Arg Ala Glu
             820                 825                 830        
 Arg Phe Arg Ile Gln Glu Glu His Arg Glu Ala Lys Leu Thr Leu Arg
         835                 840                 845            
 Pro Pro Ser Leu Ala Ala Pro Tyr Ala Pro Val Gln Ser Trp Gln His
     850                 855                 860                
 Gln Pro Glu Lys Leu Ile Phe Glu Ser Cys Gly Tyr Glu Ala Asn Tyr
 865                 870                 875                 880
 Leu Gly Ser Met Leu Ile Lys Asp Leu Arg Gly Thr Glu Ser Thr Gln
                 885                 890                 895    
 Asp Ala Cys Ala Lys Met Arg Lys Ser Thr Glu His Met Lys Lys Ile
             900                 905                 910        
 Pro Thr Ile Ile Leu Ser Ile Thr Tyr Lys Gly Val Lys Phe Ile Asp
         915                 920                 925            
 Ala Ser Asn Lys Asn Val Ile Ala Glu His Glu Ile Arg Asn Ile Ser
     930                 935                 940                
 Cys Ala Ala Gln Asp Pro Glu Asp Leu Cys Thr Phe Ala Tyr Ile Thr
 945                 950                 955                 960
 Lys Asp Leu Gln Thr Ser His His Tyr Cys His Val Phe Ser Thr Val
                 965                 970                 975    
 Asp Val Asn Leu Thr Tyr Glu Ile Ile Leu Thr Leu Gly Gln Ala Phe
             980                 985                 990        
 Glu Val Ala Tyr Gln Leu Ala Leu Gln Ala Gln Lys Ser Arg Ala Thr
         995                1000                1005            
 Gly Ala Ser Ala Ala Glu Met Ile Glu Thr Lys Ser Ser Lys Pro Val
    1010                1015                1020                
 Pro Lys Pro Arg Val Gly Val Arg Lys Ser Ala Glu Val Gly Gly Thr
1025                1030                1035                1040
 Cys Val Asp Ser Pro Ser Ile Phe Ala Met Glu Ser Gln Gly Leu Ala
                1045                1050                1055    
 Ala Leu Gly Leu Ala Leu Glu Ser Ser Ser Leu Arg Arg Lys Ala Phe
            1060                1065                1070        
 Arg Arg Thr Asn Glu Glu Ala Ala Cys Ala Leu His Thr Arg Arg Thr
        1075                1080                1085            
 Phe Phe Pro His Arg Thr Glu Leu Leu Glu Asp Arg Asp Leu Asp Gln
    1090                1095                1100                
 Val Ala Ser Ile Val Leu Trp Glu Leu Ser Asp Thr Leu His Gly Pro
1105                1110                1115                1120
 Val Arg Met Pro Met Ser Tyr Arg Cys Thr Val Leu Gly Pro Gly Phe
                1125                1130                1135    
 Leu Pro Arg Val Asp Gln Glu Pro
            1140                



      <210> 595
      <211> 1210
      <212> PRT
      <213> Homo sapiens


      <400> 595
 Met Gly Lys Glu Gln Glu Leu Leu Glu Ala Ala Arg Thr Gly His Leu
   1               5                  10                  15    
 Pro Ala Val Glu Lys Leu Leu Ser Gly Lys Arg Leu Ser Ser Gly Phe
              20                  25                  30        
 Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly
          35                  40                  45            
 Gly Gly Gly Gly Gly Leu Gly Ser Ser Ser His Pro Leu Ser Ser Leu
      50                  55                  60                
 Leu Ser Met Trp Arg Gly Pro Asn Val Asn Cys Val Asp Ser Thr Gly
  65                  70                  75                  80
 Tyr Thr Pro Leu His His Ala Ala Leu Asn Gly His Lys Asp Val Val
                  85                  90                  95    
 Glu Val Leu Leu Arg Asn Asp Ala Leu Thr Asn Val Ala Asp Ser Lys
             100                 105                 110        
 Gly Cys Tyr Pro Leu His Leu Ala Ala Trp Lys Gly Asp Ala Gln Ile
         115                 120                 125            
 Val Arg Leu Leu Ile His Gln Gly Pro Ser His Thr Arg Val Asn Glu
     130                 135                 140                
 Gln Asn Asn Asp Asn Glu Thr Ala Leu His Cys Ala Ala Gln Tyr Gly
 145                 150                 155                 160
 His Thr Glu Val Val Lys Val Leu Leu Glu Glu Leu Thr Asp Pro Thr
                 165                 170                 175    
 Met Arg Asn Asn Lys Phe Glu Thr Pro Leu Asp Leu Ala Ala Leu Tyr
             180                 185                 190        
 Gly Arg Leu Glu Val Val Lys Met Leu Leu Asn Ala His Pro Asn Leu
         195                 200                 205            
 Leu Ser Cys Asn Thr Lys Lys His Thr Pro Leu His Leu Ala Ala Arg
     210                 215                 220                
 Asn Gly His Lys Ala Val Val Gln Val Leu Leu Asp Ala Gly Met Asp
 225                 230                 235                 240
 Ser Asn Tyr Gln Thr Glu Met Gly Ser Ala Leu His Glu Ala Ala Leu
                 245                 250                 255    
 Phe Gly Lys Thr Asp Val Val Gln Ile Leu Leu Ala Ala Gly Thr Asp
             260                 265                 270        
 Val Asn Ile Lys Asp Asn His Gly Leu Thr Ala Leu Asp Thr Val Arg
         275                 280                 285            
 Glu Leu Pro Ser Gln Lys Ser Gln Gln Ile Ala Ala Leu Ile Glu Asp
     290                 295                 300                
 His Met Thr Gly Lys Arg Ser Thr Lys Glu Val Asp Lys Thr Pro Pro
 305                 310                 315                 320
 Pro Gln Pro Pro Leu Ile Ser Ser Met Asp Ser Ile Ser Gln Lys Ser
                 325                 330                 335    
 Gln Gly Asp Val Glu Lys Ala Val Thr Glu Leu Ile Ile Asp Phe Asp
             340                 345                 350        
 Ala Asn Ala Glu Glu Glu Gly Pro Tyr Glu Ala Leu Tyr Asn Ala Ile
         355                 360                 365            
 Ser Cys His Ser Leu Asp Ser Met Ala Ser Gly Arg Ser Ser Asp Gln
     370                 375                 380                
 Asp Ser Thr Asn Lys Glu Ala Glu Ala Ala Gly Val Lys Pro Ala Gly
 385                 390                 395                 400
 Val Arg Pro Arg Glu Arg Pro Pro Pro Pro Ala Lys Pro Pro Pro Asp
                 405                 410                 415    
 Glu Glu Glu Glu Asp His Ile Asp Lys Lys Tyr Phe Pro Leu Thr Ala
             420                 425                 430        
 Ser Glu Val Leu Ser Met Arg Pro Arg Ile His Gly Ser Ala Ala Arg
         435                 440                 445            
 Glu Glu Asp Glu His Pro Tyr Glu Leu Leu Leu Thr Ala Glu Thr Lys
     450                 455                 460                
 Lys Val Val Leu Val Asp Gly Lys Thr Lys Asp His Arg Arg Ser Ser
 465                 470                 475                 480
 Ser Ser Arg Ser Gln Asp Ser Ala Glu Gly Gln Asp Gly Gln Val Pro
                 485                 490                 495    
 Glu Gln Phe Ser Gly Leu Leu His Gly Ser Ser Pro Val Cys Glu Val
             500                 505                 510        
 Gly Gln Asp Pro Phe Gln Leu Leu Cys Thr Ala Gly Gln Ser His Pro
         515                 520                 525            
 Asp Gly Ser Pro Gln Gln Gly Ala Cys His Lys Ala Ser Met Gln Leu
     530                 535                 540                
 Glu Glu Thr Gly Val His Ala Pro Gly Ala Ser Gln Pro Ser Ala Leu
 545                 550                 555                 560
 Asp Gln Ser Lys Arg Val Gly Tyr Leu Thr Gly Leu Pro Thr Thr Asn
                 565                 570                 575    
 Ser Arg Ser His Pro Glu Thr Leu Thr His Thr Ala Ser Pro His Pro
             580                 585                 590        
 Gly Gly Ala Glu Glu Gly Asp Arg Ser Gly Ala Arg Ser Arg Ala Pro
         595                 600                 605            
 Pro Thr Ser Lys Pro Lys Ala Glu Leu Lys Leu Ser Arg Ser Leu Ser
     610                 615                 620                
 Lys Ser Asp Ser Asp Leu Leu Thr Cys Ser Pro Thr Glu Asp Ala Thr
 625                 630                 635                 640
 Met Gly Ser Arg Ser Glu Ser Leu Ser Asn Cys Ser Ile Gly Lys Lys
                 645                 650                 655    
 Arg Leu Glu Lys Ser Pro Ser Phe Ala Ser Glu Trp Asp Glu Ile Glu
             660                 665                 670        
 Lys Ile Met Ser Ser Ile Gly Glu Gly Ile Asp Phe Ser Gln Glu Arg
         675                 680                 685            
 Gln Lys Ile Ser Gly Ser Arg Thr Leu Glu Gln Ser Val Gly Glu Trp
     690                 695                 700                
 Leu Glu Ser Ile Gly Leu Gln Gln Tyr Glu Ser Lys Leu Leu Leu Asn
 705                 710                 715                 720
 Gly Phe Asp Asp Val His Phe Leu Gly Ser Asn Val Met Glu Glu Gln
                 725                 730                 735    
 Asp Leu Arg Asp Ile Gly Ile Ser Asp Pro Gln His Arg Arg Lys Leu
             740                 745                 750        
 Leu Gln Ala Ala Arg Ser Leu Pro Lys Val Lys Ala Leu Gly Tyr Asp
         755                 760                 765            
 Gly Asn Ser Pro Pro Ser Val Pro Ser Trp Leu Asp Ser Leu Gly Leu
     770                 775                 780                
 Gln Asp Tyr Val His Ser Phe Leu Ser Ser Gly Tyr Ser Ser Ile Asp
 785                 790                 795                 800
 Thr Val Lys Asn Leu Trp Glu Leu Glu Leu Val Asn Val Leu Lys Val
                 805                 810                 815    
 Gln Leu Leu Gly His Arg Lys Arg Ile Ile Ala Ser Leu Ala Asp Arg
             820                 825                 830        
 Pro Tyr Glu Glu Pro Pro Gln Lys Pro Pro Arg Phe Ser Gln Leu Arg
         835                 840                 845            
 Cys Gln Asp Leu Leu Ser Gln Thr Ser Ser Pro Leu Ser Gln Asn Asp
     850                 855                 860                
 Ser Cys Thr Gly Arg Ser Ala Asp Leu Leu Leu Pro Pro Gly Asp Thr
 865                 870                 875                 880
 Gly Arg Arg Arg His Asp Ser Leu His Asp Pro Ala Ala Pro Ser Arg
                 885                 890                 895    
 Ala Glu Arg Phe Arg Ile Gln Glu Glu His Arg Glu Ala Lys Leu Thr
             900                 905                 910        
 Leu Arg Pro Pro Ser Leu Ala Ala Pro Tyr Ala Pro Val Gln Ser Trp
         915                 920                 925            
 Gln His Gln Pro Glu Lys Leu Ile Phe Glu Ser Cys Gly Tyr Glu Ala
     930                 935                 940                
 Asn Tyr Leu Gly Ser Met Leu Ile Lys Asp Leu Arg Gly Thr Glu Ser
 945                 950                 955                 960
 Thr Gln Asp Ala Cys Ala Lys Met Arg Lys Ser Thr Glu His Met Lys
                 965                 970                 975    
 Lys Ile Pro Thr Ile Ile Leu Ser Ile Thr Tyr Lys Gly Val Lys Phe
             980                 985                 990        
 Ile Asp Ala Ser Asn Lys Asn Val Ile Ala Glu His Glu Ile Arg Asn
         995                1000                1005            
 Ile Ser Cys Ala Ala Gln Asp Pro Glu Asp Leu Cys Thr Phe Ala Tyr
    1010                1015                1020                
 Ile Thr Lys Asp Leu Gln Thr Ser His His Tyr Cys His Val Phe Ser
1025                1030                1035                1040
 Thr Val Asp Val Asn Leu Thr Tyr Glu Ile Ile Leu Thr Leu Gly Gln
                1045                1050                1055    
 Ala Phe Glu Val Ala Tyr Gln Leu Ala Leu Gln Ala Gln Lys Ser Arg
            1060                1065                1070        
 Ala Thr Gly Ala Ser Ala Ala Glu Met Ile Glu Thr Lys Ser Ser Lys
        1075                1080                1085            
 Pro Val Pro Lys Pro Arg Val Gly Val Arg Lys Ser Ala Glu Val Gly
    1090                1095                1100                
 Gly Thr Cys Val Asp Ser Pro Ser Ile Phe Ala Met Glu Ser Gln Gly
1105                1110                1115                1120
 Leu Ala Ala Leu Gly Leu Ala Leu Glu Ser Ser Ser Leu Arg Arg Lys
                1125                1130                1135    
 Ala Phe Arg Arg Thr Asn Glu Glu Ala Ala Cys Ala Leu His Thr Arg
            1140                1145                1150        
 Arg Thr Phe Phe Pro His Arg Thr Glu Leu Leu Glu Asp Arg Asp Leu
        1155                1160                1165            
 Asp Gln Val Ala Ser Ile Val Leu Trp Glu Leu Ser Asp Thr Leu His
    1170                1175                1180                
 Gly Pro Val Arg Met Pro Met Ser Tyr Arg Cys Thr Val Leu Gly Pro
1185                1190                1195                1200
 Gly Phe Leu Pro Arg Val Asp Gln Glu Pro
                1205                1210



      <210> 596
      <211> 612
      <212> PRT
      <213> Homo sapiens


      <400> 596
 Met Lys Val Val Thr Gln Glu Gln Asp Asn Gln Gly Ser Val Thr Gly
   1               5                  10                  15    
 Ala Ala Thr Phe Ala Ile Tyr Leu Pro Leu Ala Thr Thr Gly His Gln
              20                  25                  30        
 Arg Lys Thr Gln Ala Pro Tyr Ala Leu Lys Glu Ala Trp Pro Leu Arg
          35                  40                  45            
 Arg Ser Val Val Gly Leu Val Ala Gly Ala Asn Arg Glu Glu Thr Ala
      50                  55                  60                
 Gly Val Ala Val Ala Arg Leu Gly Ile Thr Pro Gly Asp Trp Pro Ala
  65                  70                  75                  80
 Arg Phe Val Pro Ala Gly Ser Arg Ala Gly Gly Leu Phe Gly Asn Ser
                  85                  90                  95    
 Glu Pro Gln Arg Asn Met Ala Leu Pro Thr Leu Pro Ser Tyr Trp Cys
             100                 105                 110        
 Ser Gln Gln Arg Leu Asn Gln Gln Leu Ala Arg Gln Arg Glu Gln Glu
         115                 120                 125            
 Ala Arg Leu Arg Gln Gln Trp Glu Gln Asn Ser Arg Tyr Phe Arg Met
     130                 135                 140                
 Ser Asp Ile Cys Ser Ser Lys Gln Ala Glu Trp Ser Ser Lys Thr Ser
 145                 150                 155                 160
 Tyr Gln Arg Ser Met His Ala Tyr Gln Arg Glu Lys Met Lys Glu Glu
                 165                 170                 175    
 Lys Arg Arg Ser Leu Glu Ala Arg Arg Glu Lys Leu Arg Gln Leu Met
             180                 185                 190        
 Gln Glu Glu Gln Asp Leu Leu Ala Arg Glu Leu Glu Glu Leu Arg Leu
         195                 200                 205            
 Ser Met Asn Leu Gln Glu Arg Arg Ile Arg Glu Gln His Gly Lys Leu
     210                 215                 220                
 Lys Ser Ala Lys Glu Glu Gln Arg Lys Leu Ile Ala Glu Gln Leu Leu
 225                 230                 235                 240
 Tyr Glu His Trp Lys Lys Asn Asn Pro Lys Leu Arg Glu Met Glu Leu
                 245                 250                 255    
 Asp Leu His Gln Lys His Val Val Asn Ser Trp Glu Met Gln Lys Glu
             260                 265                 270        
 Glu Lys Lys Gln Gln Glu Ala Thr Ala Glu Gln Glu Asn Lys Arg Tyr
         275                 280                 285            
 Glu Asn Glu Tyr Glu Arg Ala Arg Arg Glu Ala Leu Glu Arg Met Lys
     290                 295                 300                
 Ala Glu Glu Glu Arg Arg Gln Leu Glu Asp Lys Leu Gln Ala Glu Ala
 305                 310                 315                 320
 Leu Leu Gln Gln Met Glu Glu Leu Lys Leu Lys Glu Val Glu Ala Thr
                 325                 330                 335    
 Lys Leu Lys Lys Glu Gln Glu Asn Leu Leu Lys Gln Arg Trp Glu Leu
             340                 345                 350        
 Glu Arg Leu Glu Glu Glu Arg Lys Gln Met Glu Ala Phe Arg Gln Lys
         355                 360                 365            
 Ala Glu Leu Gly Arg Phe Leu Arg His Gln Tyr Asn Ala Gln Leu Ser
     370                 375                 380                
 Arg Arg Thr Gln Gln Ile Gln Glu Glu Leu Glu Ala Asp Arg Arg Ile
 385                 390                 395                 400
 Leu Gln Ala Leu Leu Glu Lys Glu Asp Glu Ser Gln Arg Leu His Leu
                 405                 410                 415    
 Ala Arg Arg Glu Gln Val Met Ala Asp Val Ala Trp Met Lys Gln Ala
             420                 425                 430        
 Ile Glu Glu Gln Leu Gln Leu Glu Arg Ala Arg Glu Ala Glu Leu Gln
         435                 440                 445            
 Met Leu Leu Arg Glu Glu Ala Lys Glu Met Trp Glu Lys Arg Glu Ala
     450                 455                 460                
 Glu Trp Ala Arg Glu Arg Ser Ala Arg Asp Arg Leu Met Ser Glu Val
 465                 470                 475                 480
 Leu Thr Gly Arg Gln Gln Gln Ile Gln Glu Lys Ile Glu Gln Asn Arg
                 485                 490                 495    
 Arg Ala Gln Glu Glu Ser Leu Lys His Arg Glu Gln Leu Ile Arg Asn
             500                 505                 510        
 Leu Glu Glu Val Arg Glu Leu Ala Arg Arg Glu Lys Glu Glu Ser Glu
         515                 520                 525            
 Lys Leu Lys Ser Ala Arg Lys Gln Glu Leu Glu Ala Gln Val Ala Glu
     530                 535                 540                
 Arg Arg Leu Gln Ala Trp Glu Ala Asp Gln Gln Glu Glu Glu Glu Glu
 545                 550                 555                 560
 Glu Glu Ala Arg Arg Val Glu Gln Leu Ser Asp Ala Leu Leu Gln Gln
                 565                 570                 575    
 Glu Ala Glu Thr Met Ala Glu Gln Gly Tyr Arg Pro Ser Leu Thr Asp
             580                 585                 590        
 Ile Gln Lys Leu Leu Gly Thr Asp Phe Met Gly Thr Ile Ser Thr Glu
         595                 600                 605            
 Asn Lys Gly Cys
     610        



      <210> 597
      <211> 555
      <212> PRT
      <213> Homo sapiens


      <400> 597
 Met Leu Arg Glu Lys Phe Pro Glu Phe Cys Ser Ser Pro Ser Pro Pro
   1               5                  10                  15    
 Val Glu Val Lys Ile Glu Glu Pro Val Ser Met Glu Met Asp Asn His
              20                  25                  30        
 Met Ser Asp Lys Asp Glu Ser Cys Tyr Asp Asn Ala Glu Ala Ala Phe
          35                  40                  45            
 Ser Asp Asp Glu Glu Asp Leu Asn Ser Lys Gly Lys Lys Arg Glu Phe
      50                  55                  60                
 Arg Phe His Pro Ile Lys Glu Thr Val Val Glu Glu Pro Val Asp Ile
  65                  70                  75                  80
 Thr Pro Tyr Leu Asp Gln Leu Asp Glu Ser Leu Arg Asp Lys Val Leu
                  85                  90                  95    
 Gln Leu Gln Lys Gly Ser Asp Thr Glu Ala Gln Cys Glu Val Met Gln
             100                 105                 110        
 Glu Ile Val Asp Gln Val Leu Glu Glu Asp Phe Asp Ser Glu Gln Leu
         115                 120                 125            
 Ser Val Leu Ala Ser Cys Leu Gln Glu Leu Phe Lys Ala His Phe Arg
     130                 135                 140                
 Gly Glu Val Leu Pro Glu Glu Ile Thr Glu Glu Ser Leu Glu Glu Ser
 145                 150                 155                 160
 Val Gly Lys Pro Leu Tyr Leu Ile Phe Arg Asn Leu Cys Gln Met Gln
                 165                 170                 175    
 Glu Asp Asn Ser Ser Phe Ser Leu Leu Leu Asp Leu Leu Ser Glu Leu
             180                 185                 190        
 Tyr Gln Lys Gln Pro Lys Ile Gly Tyr His Leu Leu Tyr Tyr Leu Arg
         195                 200                 205            
 Ala Ser Lys Ala Ala Ala Gly Lys Met Asn Leu Tyr Glu Ser Phe Ala
     210                 215                 220                
 Gln Ala Thr Gln Leu Gly Asp Leu His Thr Cys Leu Met Met Asp Met
 225                 230                 235                 240
 Lys Ala Cys Gln Glu Asp Asp Val Arg Leu Leu Cys His Leu Thr Pro
                 245                 250                 255    
 Ser Ile Tyr Thr Glu Phe Pro Asp Glu Thr Leu Arg Ser Gly Glu Leu
             260                 265                 270        
 Leu Asn Met Ile Val Ala Val Ile Asp Ser Ala Gln Leu Gln Glu Leu
         275                 280                 285            
 Val Cys His Val Met Met Gly Asn Leu Val Met Phe Arg Lys Asp Ser
     290                 295                 300                
 Val Leu Asn Ile Leu Ile Gln Ser Leu Asp Trp Glu Thr Phe Glu Gln
 305                 310                 315                 320
 Tyr Cys Ala Trp Gln Leu Phe Leu Ala His Asn Ile Pro Leu Glu Thr
                 325                 330                 335    
 Ile Ile Pro Ile Leu Gln His Leu Lys Tyr Lys Glu His Pro Glu Ala
             340                 345                 350        
 Leu Ser Cys Leu Leu Leu Gln Leu Arg Arg Glu Lys Pro Ser Glu Glu
         355                 360                 365            
 Met Val Lys Met Val Leu Ser Arg Pro Cys His Pro Asp Asp Gln Phe
     370                 375                 380                
 Thr Thr Ser Ile Leu Arg His Trp Cys Met Lys His Asp Glu Leu Leu
 385                 390                 395                 400
 Ala Glu His Ile Lys Ser Leu Leu Ile Lys Asn Asn Ser Leu Pro Arg
                 405                 410                 415    
 Lys Arg Gln Ser Leu Arg Ser Ser Ser Ser Lys Leu Ala Gln Leu Thr
             420                 425                 430        
 Leu Glu Gln Ile Leu Glu His Leu Asp Asn Leu Arg Leu Asn Leu Thr
         435                 440                 445            
 Asn Thr Lys Gln Asn Phe Phe Ser Gln Thr Pro Ile Leu Gln Ala Leu
     450                 455                 460                
 Gln His Val Gln Ala Ser Cys Asp Glu Ala His Lys Met Lys Phe Ser
 465                 470                 475                 480
 Asp Leu Phe Ser Leu Ala Glu Glu Tyr Glu Asp Ser Ser Thr Lys Pro
                 485                 490                 495    
 Pro Lys Ser Arg Arg Lys Ala Ala Leu Ser Ser Pro Arg Ser Arg Lys
             500                 505                 510        
 Asn Ala Thr Gln Pro Pro Asn Ala Glu Glu Glu Ser Gly Ser Ser Ser
         515                 520                 525            
 Ala Ser Glu Glu Glu Asp Thr Lys Pro Lys Pro Thr Lys Arg Lys Arg
     530                 535                 540                
 Lys Gly Ser Ser Ala Val Gly Ser Asp Ser Asp
 545                 550                 555



      <210> 598
      <211> 589
      <212> PRT
      <213> Homo sapiens


      <400> 598
 Met Ser Ser Trp Leu Leu Glu Glu Phe Leu Ser Cys His Arg Ile Thr
   1               5                  10                  15    
 Lys His Leu Ala Pro Leu Phe Asp Asn Pro Lys Leu Asp Lys Glu Leu
              20                  25                  30        
 Arg Ala Met Leu Arg Glu Lys Phe Pro Glu Phe Cys Ser Ser Pro Ser
          35                  40                  45            
 Pro Pro Val Glu Val Lys Ile Glu Glu Pro Val Ser Met Glu Met Asp
      50                  55                  60                
 Asn His Met Ser Asp Lys Asp Glu Ser Cys Tyr Asp Asn Ala Glu Ala
  65                  70                  75                  80
 Ala Phe Ser Asp Asp Glu Glu Asp Leu Asn Ser Lys Gly Lys Lys Arg
                  85                  90                  95    
 Glu Phe Arg Phe His Pro Ile Lys Glu Thr Val Val Glu Glu Pro Val
             100                 105                 110        
 Asp Ile Thr Pro Tyr Leu Asp Gln Leu Asp Glu Ser Leu Arg Asp Lys
         115                 120                 125            
 Val Leu Gln Leu Gln Lys Gly Ser Asp Thr Glu Ala Gln Cys Glu Val
     130                 135                 140                
 Met Gln Glu Ile Val Asp Gln Val Leu Glu Glu Asp Phe Asp Ser Glu
 145                 150                 155                 160
 Gln Leu Ser Val Leu Ala Ser Cys Leu Gln Glu Leu Phe Lys Ala His
                 165                 170                 175    
 Phe Arg Gly Glu Val Leu Pro Glu Glu Ile Thr Glu Glu Ser Leu Glu
             180                 185                 190        
 Glu Ser Val Gly Lys Pro Leu Tyr Leu Ile Phe Arg Asn Leu Cys Gln
         195                 200                 205            
 Met Gln Glu Asp Asn Ser Ser Phe Ser Leu Leu Leu Asp Leu Leu Ser
     210                 215                 220                
 Glu Leu Tyr Gln Lys Gln Pro Lys Ile Gly Tyr His Leu Leu Tyr Tyr
 225                 230                 235                 240
 Leu Arg Ala Ser Lys Ala Ala Ala Gly Lys Met Asn Leu Tyr Glu Ser
                 245                 250                 255    
 Phe Ala Gln Ala Thr Gln Leu Gly Asp Leu His Thr Cys Leu Met Met
             260                 265                 270        
 Asp Met Lys Ala Cys Gln Glu Asp Asp Val Arg Leu Leu Cys His Leu
         275                 280                 285            
 Thr Pro Ser Ile Tyr Thr Glu Phe Pro Asp Glu Thr Leu Arg Ser Gly
     290                 295                 300                
 Glu Leu Leu Asn Met Ile Val Ala Val Ile Asp Ser Ala Gln Leu Gln
 305                 310                 315                 320
 Glu Leu Val Cys His Val Met Met Gly Asn Leu Val Met Phe Arg Lys
                 325                 330                 335    
 Asp Ser Val Leu Asn Ile Leu Ile Gln Ser Leu Asp Trp Glu Thr Phe
             340                 345                 350        
 Glu Gln Tyr Cys Ala Trp Gln Leu Phe Leu Ala His Asn Ile Pro Leu
         355                 360                 365            
 Glu Thr Ile Ile Pro Ile Leu Gln His Leu Lys Tyr Lys Glu His Pro
     370                 375                 380                
 Glu Ala Leu Ser Cys Leu Leu Leu Gln Leu Arg Arg Glu Lys Pro Ser
 385                 390                 395                 400
 Glu Glu Met Val Lys Met Val Leu Ser Arg Pro Cys His Pro Asp Asp
                 405                 410                 415    
 Gln Phe Thr Thr Ser Ile Leu Arg His Trp Cys Met Lys His Asp Glu
             420                 425                 430        
 Leu Leu Ala Glu His Ile Lys Ser Leu Leu Ile Lys Asn Asn Ser Leu
         435                 440                 445            
 Pro Arg Lys Arg Gln Ser Leu Arg Ser Ser Ser Ser Lys Leu Ala Gln
     450                 455                 460                
 Leu Thr Leu Glu Gln Ile Leu Glu His Leu Asp Asn Leu Arg Leu Asn
 465                 470                 475                 480
 Leu Thr Asn Thr Lys Gln Asn Phe Phe Ser Gln Thr Pro Ile Leu Gln
                 485                 490                 495    
 Ala Leu Gln His Val Gln Ala Ser Cys Asp Glu Ala His Lys Met Lys
             500                 505                 510        
 Phe Ser Asp Leu Phe Ser Leu Ala Glu Glu Tyr Glu Asp Ser Ser Thr
         515                 520                 525            
 Lys Pro Pro Lys Ser Arg Arg Lys Ala Ala Leu Ser Ser Pro Arg Ser
     530                 535                 540                
 Arg Lys Asn Ala Thr Gln Pro Pro Asn Ala Glu Glu Glu Ser Gly Ser
 545                 550                 555                 560
 Ser Ser Ala Ser Glu Glu Glu Asp Thr Lys Pro Lys Pro Thr Lys Arg
                 565                 570                 575    
 Lys Arg Lys Gly Ser Ser Ala Val Gly Ser Asp Ser Asp
             580                 585                



      <210> 599
      <211> 98
      <212> PRT
      <213> Homo sapiens


      <400> 599
 Met Gly Lys Lys Trp Gly Trp Gln Glu Met Glu Asn Gly Gly Ala Ala
   1               5                  10                  15    
 Pro Ala Trp Gly Ala Gly Pro Pro Val His Pro Ala Pro Pro Pro Val
              20                  25                  30        
 Glu Lys Thr Leu Ser Trp Gly Cys Gly Phe Gly Leu His Ser Gly Phe
          35                  40                  45            
 Gly Gly Ser Gly Gly Gly Val Gly Leu Cys Arg Leu Leu Cys Leu Val
      50                  55                  60                
 Arg Leu Phe Cys Cys Ser Ser Ile Leu Tyr Gln Arg Gln Glu Arg Gly
  65                  70                  75                  80
 Val Lys Ser Leu Phe Tyr Pro Pro Asn Lys Leu Ser His Ser Glu Ala
                  85                  90                  95    
 Glu Ala
        



      <210> 600
      <211> 478
      <212> PRT
      <213> Homo sapiens


      <400> 600
 Met Leu Pro Asp Trp Thr Ala Leu Pro Leu Pro Cys Ala Ser Ala His
   1               5                  10                  15    
 Val Pro Cys Glu Ser Cys Trp Thr Ala Gln Cys Ala Asp Gly Val Pro
              20                  25                  30        
 Pro Cys Leu Val Ser Val Gln Pro His Val Pro Val Leu Thr Tyr Pro
          35                  40                  45            
 Val Leu Ala Ala Phe Leu Arg Arg Val Glu Ala Met Val Ile Arg Glu
      50                  55                  60                
 Leu Asn Lys Asn Trp Gln Ser His Ala Phe Asp Gly Phe Glu Val Asn
  65                  70                  75                  80
 Trp Thr Glu Gln Gln Gln Met Val Ser Cys Leu Tyr Thr Leu Gly Tyr
                  85                  90                  95    
 Pro Pro Ala Gln Ala Gln Gly Leu His Val Thr Ser Ile Ser Trp Asn
             100                 105                 110        
 Ser Thr Gly Ser Val Val Ala Cys Ala Tyr Gly Arg Leu Asp His Gly
         115                 120                 125            
 Asp Trp Ser Thr Leu Lys Ser Phe Val Cys Ala Trp Asn Leu Asp Arg
     130                 135                 140                
 Arg Asp Leu Arg Pro Gln Gln Pro Ser Ala Val Val Glu Val Pro Ser
 145                 150                 155                 160
 Ala Val Leu Cys Leu Ala Phe His Pro Thr Gln Pro Ser His Val Ala
                 165                 170                 175    
 Gly Gly Leu Tyr Ser Gly Glu Val Leu Val Trp Asp Leu Ser Arg Leu
             180                 185                 190        
 Glu Asp Pro Leu Leu Trp Arg Thr Gly Leu Thr Asp Asp Thr His Thr
         195                 200                 205            
 Asp Pro Val Ser Gln Val Val Trp Leu Pro Glu Pro Gly His Ser His
     210                 215                 220                
 Arg Phe Gln Val Leu Ser Val Ala Thr Asp Gly Lys Val Leu Leu Trp
 225                 230                 235                 240
 Gln Gly Ile Gly Val Gly Gln Leu Gln Leu Thr Glu Gly Phe Ala Leu
                 245                 250                 255    
 Val Met Gln Gln Leu Pro Arg Ser Thr Lys Leu Lys Lys His Pro Arg
             260                 265                 270        
 Gly Glu Thr Glu Val Gly Ala Thr Ala Val Ala Phe Ser Ser Phe Asp
         275                 280                 285            
 Pro Arg Leu Phe Ile Leu Gly Thr Glu Gly Gly Phe Pro Leu Lys Cys
     290                 295                 300                
 Ser Leu Ala Ala Gly Glu Ala Ala Leu Thr Arg Met Pro Ser Ser Val
 305                 310                 315                 320
 Pro Leu Arg Ala Pro Ala Gln Phe Thr Phe Ser Pro His Gly Gly Pro
                 325                 330                 335    
 Ile Tyr Ser Val Ser Cys Ser Pro Phe His Arg Asn Leu Phe Leu Ser
             340                 345                 350        
 Ala Gly Thr Asp Gly His Val His Leu Tyr Ser Met Leu Gln Ala Pro
         355                 360                 365            
 Pro Leu Thr Ser Leu Gln Leu Ser Leu Lys Tyr Leu Phe Ala Val Arg
     370                 375                 380                
 Trp Ser Pro Val Arg Pro Leu Val Phe Ala Ala Ala Ser Gly Lys Gly
 385                 390                 395                 400
 Asp Val Gln Leu Phe Asp Leu Gln Lys Ser Ser Gln Lys Pro Thr Val
                 405                 410                 415    
 Leu Ile Lys Gln Thr Gln Asp Glu Ser Pro Val Tyr Cys Leu Glu Phe
             420                 425                 430        
 Asn Ser Gln Gln Thr Gln Leu Leu Ala Ala Gly Asp Ala Gln Gly Thr
         435                 440                 445            
 Val Lys Val Trp Gln Leu Ser Thr Glu Phe Thr Glu Gln Gly Pro Arg
     450                 455                 460                
 Glu Ala Glu Asp Leu Asp Cys Leu Ala Ala Glu Val Ala Ala
 465                 470                 475            



      <210> 601
      <211> 164
      <212> PRT
      <213> Homo sapiens


      <400> 601
 Met Leu Arg Glu Leu Gly Arg Ala Cys Ser Ala Gln Arg Arg Glu Asp
   1               5                  10                  15    
 Ser Ser Arg Gln Gly Glu Arg Val Pro Phe Leu Pro Leu Trp Pro Ala
              20                  25                  30        
 Pro Pro Glu Pro Ser Arg Tyr Pro Gly Val Pro Arg Gly Ala Ser Pro
          35                  40                  45            
 Ser Ala Thr Ala Val Ser Trp Arg Ala Ala Ala Met Ala Leu Arg Tyr
      50                  55                  60                
 Pro Met Ala Val Gly Leu Asn Lys Gly His Lys Val Thr Lys Asn Val
  65                  70                  75                  80
 Ser Lys Pro Arg His Ser Arg Arg Arg Gly Arg Leu Thr Lys His Thr
                  85                  90                  95    
 Lys Phe Val Arg Asp Met Ile Arg Glu Val Cys Gly Phe Ala Pro Tyr
             100                 105                 110        
 Glu Arg Arg Ala Met Glu Leu Leu Lys Val Ser Lys Asp Lys Arg Ala
         115                 120                 125            
 Leu Lys Phe Ile Lys Lys Arg Val Gly Thr His Ile Arg Ala Lys Arg
     130                 135                 140                
 Lys Arg Glu Glu Leu Ser Asn Val Leu Ala Ala Met Arg Lys Ala Ala
 145                 150                 155                 160
 Ala Lys Lys Asp
                



      <210> 602
      <211> 158
      <212> PRT
      <213> Homo sapiens


      <400> 602
 Met Gly Asp Asn Pro Phe Gln Pro Lys Ser Asn Ser Lys Met Ala Glu
   1               5                  10                  15    
 Leu Phe Met Glu Cys Glu Glu Glu Glu Leu Glu Pro Trp Gln Lys Lys
              20                  25                  30        
 Val Lys Glu Val Glu Asp Asp Asp Asp Asp Glu Pro Ile Phe Val Gly
          35                  40                  45            
 Glu Ile Ser Ser Ser Lys Pro Ala Ile Ser Asn Ile Leu Asn Arg Val
      50                  55                  60                
 Asn Pro Ser Ser Tyr Ser Arg Gly Leu Lys Asn Gly Ala Leu Ser Arg
  65                  70                  75                  80
 Gly Ile Thr Ala Ala Phe Lys Pro Thr Ser Gln His Tyr Thr Asn Pro
                  85                  90                  95    
 Thr Ser Asn Pro Val Pro Ala Ser Pro Ile Asn Phe His Pro Glu Ser
             100                 105                 110        
 Arg Ser Ser Asp Ser Ser Val Ile Val Gln Pro Phe Ser Lys Pro Val
         115                 120                 125            
 Ser Val Ser Lys Thr Ile Arg Pro Ala Gln Gly Ser Ile Gly Cys Cys
     130                 135                 140                
 Leu Ser Ile Ser Thr Val Pro Ser Tyr Asn Ser Gly Leu Ser
 145                 150                 155            



      <210> 603
      <211> 1112
      <212> PRT
      <213> Homo sapiens


      <400> 603
 Met Met Arg Thr Gly Gly Phe Leu Val Gln Phe Phe Leu Cys Ser Arg
   1               5                  10                  15    
 Asn Ser Glu Met Leu Lys Asn Ser Ala Gln His Phe Ser Gln Thr Cys
              20                  25                  30        
 Val Ser Ser Arg Arg Ser Arg Phe Thr Val Ala Ser Ser Ser Leu Ala
          35                  40                  45            
 Thr Ser Ser Phe Pro Gly Trp Phe Thr Gly Ala Leu Ser Arg Arg Lys
      50                  55                  60                
 Gln Ala Lys Pro Gln His Ile Asn Ser Glu Glu Asp Gln Gly Glu Gln
  65                  70                  75                  80
 Gln Pro Gln Gln Gln Thr Pro Glu Phe Ala Asp Ala Ala Pro Ala Ala
                  85                  90                  95    
 Pro Ala Ala Gly Glu Leu Gly Ala Pro Val Asn His Pro Gly Asn Asp
             100                 105                 110        
 Glu Val Ala Ser Glu Asp Glu Ala Thr Val Lys Arg Leu Arg Arg Glu
         115                 120                 125            
 Glu Thr His Val Cys Glu Lys Cys Cys Ala Glu Phe Phe Ser Ile Ser
     130                 135                 140                
 Glu Phe Leu Glu His Lys Lys Asn Cys Thr Lys Asn Pro Pro Val Leu
 145                 150                 155                 160
 Ile Met Asn Asp Ser Glu Gly Pro Val Pro Ser Glu Asp Phe Ser Gly
                 165                 170                 175    
 Ala Val Leu Ser His Gln Pro Thr Ser Pro Gly Ser Lys Asp Cys His
             180                 185                 190        
 Arg Glu Asn Gly Gly Ser Ser Glu Asp Met Lys Glu Lys Pro Asp Ala
         195                 200                 205            
 Glu Ser Val Val Tyr Leu Lys Thr Glu Thr Ala Leu Pro Pro Thr Pro
     210                 215                 220                
 Gln Asp Ile Ser Tyr Leu Ala Lys Gly Lys Val Ala Asn Thr Asn Val
 225                 230                 235                 240
 Thr Leu Gln Ala Leu Arg Gly Thr Lys Val Ala Val Asn Gln Arg Ser
                 245                 250                 255    
 Ala Asp Ala Leu Pro Ala Pro Val Pro Gly Ala Asn Ser Ile Pro Trp
             260                 265                 270        
 Val Leu Glu Gln Ile Leu Cys Leu Gln Gln Gln Gln Leu Gln Gln Ile
         275                 280                 285            
 Gln Leu Thr Glu Gln Ile Arg Ile Gln Val Asn Met Trp Ala Ser His
     290                 295                 300                
 Ala Leu His Ser Ser Gly Ala Gly Ala Asp Thr Leu Lys Thr Leu Gly
 305                 310                 315                 320
 Ser His Met Ser Gln Gln Val Ser Ala Ala Val Ala Leu Leu Ser Gln
                 325                 330                 335    
 Lys Ala Gly Ser Gln Gly Leu Ser Leu Asp Ala Leu Lys Gln Ala Lys
             340                 345                 350        
 Leu Pro His Ala Asn Ile Pro Ser Ala Thr Ser Ser Leu Ser Pro Gly
         355                 360                 365            
 Leu Ala Pro Phe Thr Leu Lys Pro Asp Gly Thr Arg Val Leu Pro Asn
     370                 375                 380                
 Val Met Ser Arg Leu Pro Ser Ala Leu Leu Pro Gln Ala Pro Gly Ser
 385                 390                 395                 400
 Val Leu Phe Gln Ser Pro Phe Ser Thr Val Ala Leu Asp Thr Ser Lys
                 405                 410                 415    
 Lys Gly Lys Gly Lys Pro Pro Asn Ile Ser Ala Val Asp Val Lys Pro
             420                 425                 430        
 Lys Asp Glu Ala Ala Leu Tyr Lys His Lys Cys Lys Tyr Cys Ser Lys
         435                 440                 445            
 Val Phe Gly Thr Asp Ser Ser Leu Gln Ile His Leu Arg Ser His Thr
     450                 455                 460                
 Gly Glu Arg Pro Phe Val Cys Ser Val Cys Gly His Arg Phe Thr Thr
 465                 470                 475                 480
 Lys Gly Asn Leu Lys Val His Phe His Arg His Pro Gln Val Lys Ala
                 485                 490                 495    
 Asn Pro Gln Leu Phe Ala Glu Phe Gln Asp Lys Val Ala Ala Gly Asn
             500                 505                 510        
 Gly Ile Pro Tyr Ala Leu Ser Val Pro Asp Pro Ile Asp Glu Pro Ser
         515                 520                 525            
 Leu Ser Leu Asp Ser Lys Pro Val Leu Val Thr Thr Ser Val Gly Leu
     530                 535                 540                
 Pro Gln Asn Leu Ser Ser Gly Thr Asn Pro Lys Asp Leu Thr Gly Gly
 545                 550                 555                 560
 Ser Leu Pro Gly Asp Leu Gln Pro Gly Pro Ser Pro Glu Ser Glu Gly
                 565                 570                 575    
 Gly Pro Thr Leu Pro Gly Val Gly Pro Asn Tyr Asn Ser Pro Arg Ala
             580                 585                 590        
 Gly Gly Phe Gln Gly Ser Gly Thr Pro Glu Pro Gly Ser Glu Thr Leu
         595                 600                 605            
 Lys Leu Gln Gln Leu Val Glu Asn Ile Asp Lys Ala Thr Thr Asp Pro
     610                 615                 620                
 Asn Glu Cys Leu Ile Cys His Arg Val Leu Ser Cys Gln Ser Ser Leu
 625                 630                 635                 640
 Lys Met His Tyr Arg Thr His Thr Gly Glu Arg Pro Phe Gln Cys Lys
                 645                 650                 655    
 Ile Cys Gly Arg Ala Phe Ser Thr Lys Gly Asn Leu Lys Thr His Leu
             660                 665                 670        
 Gly Val His Arg Thr Asn Thr Ser Ile Lys Thr Gln His Ser Cys Pro
         675                 680                 685            
 Ile Cys Gln Lys Lys Phe Thr Asn Ala Val Met Leu Gln Gln His Ile
     690                 695                 700                
 Arg Met His Met Gly Gly Gln Ile Pro Asn Thr Pro Leu Pro Glu Asn
 705                 710                 715                 720
 Pro Cys Asp Phe Thr Gly Ser Glu Pro Met Thr Val Gly Glu Asn Gly
                 725                 730                 735    
 Ser Thr Gly Ala Ile Cys His Asp Asp Val Ile Glu Ser Ile Asp Val
             740                 745                 750        
 Glu Glu Val Ser Ser Gln Glu Ala Pro Ser Ser Ser Ser Lys Val Pro
         755                 760                 765            
 Thr Pro Leu Pro Ser Ile His Ser Ala Ser Pro Thr Leu Gly Phe Ala
     770                 775                 780                
 Met Met Ala Ser Leu Asp Ala Pro Gly Lys Val Gly Pro Ala Pro Phe
 785                 790                 795                 800
 Asn Leu Gln Arg Gln Gly Ser Arg Glu Asn Gly Ser Val Glu Ser Asp
                 805                 810                 815    
 Gly Leu Thr Asn Asp Ser Ser Ser Leu Met Gly Asp Gln Glu Tyr Gln
             820                 825                 830        
 Ser Arg Ser Pro Asp Ile Leu Glu Thr Thr Ser Phe Gln Ala Leu Ser
         835                 840                 845            
 Pro Ala Asn Ser Gln Ala Glu Ser Ile Lys Ser Lys Ser Pro Asp Ala
     850                 855                 860                
 Gly Ser Lys Ala Glu Ser Ser Glu Asn Ser Arg Thr Glu Met Glu Gly
 865                 870                 875                 880
 Arg Ser Ser Leu Pro Ser Thr Phe Ile Arg Ala Pro Pro Thr Tyr Val
                 885                 890                 895    
 Lys Val Glu Val Pro Gly Thr Phe Val Gly Pro Ser Thr Leu Ser Pro
             900                 905                 910        
 Gly Met Thr Pro Leu Leu Ala Ala Gln Pro Arg Arg Gln Ala Lys Gln
         915                 920                 925            
 His Gly Cys Thr Arg Cys Gly Lys Asn Phe Ser Ser Ala Ser Ala Leu
     930                 935                 940                
 Gln Ile His Glu Arg Thr His Thr Gly Glu Lys Pro Phe Val Cys Asn
 945                 950                 955                 960
 Ile Cys Gly Arg Ala Phe Thr Thr Lys Gly Asn Leu Lys Val His Tyr
                 965                 970                 975    
 Met Thr His Gly Ala Asn Asn Asn Ser Ala Arg Arg Gly Arg Lys Leu
             980                 985                 990        
 Ala Ile Glu Asn Thr Met Ala Leu Leu Gly Thr Asp Gly Lys Arg Val
         995                1000                1005            
 Ser Glu Ile Phe Pro Lys Glu Ile Leu Ala Pro Ser Val Asn Val Asp
    1010                1015                1020                
 Pro Val Val Trp Asn Gln Tyr Thr Ser Met Leu Asn Gly Gly Leu Ala
1025                1030                1035                1040
 Val Lys Thr Asn Glu Ile Ser Val Ile Gln Ser Gly Gly Val Pro Thr
                1045                1050                1055    
 Leu Pro Val Ser Leu Gly Ala Thr Ser Val Val Asn Asn Ala Thr Val
            1060                1065                1070        
 Ser Lys Met Asp Gly Ser Gln Ser Gly Ile Ser Ala Asp Val Glu Lys
        1075                1080                1085            
 Pro Ser Ala Thr Asp Gly Val Pro Lys His Gln Phe Pro His Phe Leu
    1090                1095                1100                
 Glu Glu Asn Lys Ile Ala Val Ser
1105                1110        



      <210> 604
      <211> 239
      <212> PRT
      <213> Homo sapiens


      <400> 604
 Met Met Ala Ala Arg Arg Arg Ala Gly Leu Val Pro Gly Gly Arg Cys
   1               5                  10                  15    
 Glu Ala Arg Asp Pro Arg Cys Leu Gly Ser Ser Ala Pro Ala Pro Ala
              20                  25                  30        
 Ala Pro Ala Ala Ala Met Ser Gly Arg Ser Val Arg Ala Glu Thr Arg
          35                  40                  45            
 Ser Arg Ala Lys Asp Asp Ile Lys Lys Val Met Ala Ala Ile Glu Lys
      50                  55                  60                
 Val Arg Lys Trp Glu Lys Lys Trp Val Thr Val Gly Asp Thr Ser Leu
  65                  70                  75                  80
 Arg Ile Phe Lys Trp Val Pro Val Thr Asp Ser Lys Glu Lys Glu Lys
                  85                  90                  95    
 Ser Lys Ser Asn Ser Ser Ala Ala Arg Glu Pro Asn Gly Phe Pro Ser
             100                 105                 110        
 Asp Ala Ser Ala Asn Ser Ser Leu Leu Leu Glu Phe Gln Asp Glu Asn
         115                 120                 125            
 Ser Asn Gln Ser Ser Val Ser Asp Val Tyr Gln Leu Lys Val Asp Ser
     130                 135                 140                
 Ser Thr Asn Ser Ser Pro Ser Pro Gln Gln Ser Glu Ser Leu Ser Pro
 145                 150                 155                 160
 Ala His Thr Ser Asp Phe Arg Thr Asp Asp Ser Gln Pro Pro Thr Leu
                 165                 170                 175    
 Gly Gln Glu Ile Leu Glu Glu Pro Ser Leu Pro Ser Ser Glu Val Ala
             180                 185                 190        
 Asp Glu Pro Pro Thr Leu Thr Lys Glu Glu Pro Val Pro Leu Glu Thr
         195                 200                 205            
 Gln Val Val Glu Glu Glu Glu Asp Ser Gly Ala Pro Pro Leu Lys Arg
     210                 215                 220                
 Phe Cys Val Asp Gln Pro Thr Val Pro Gln Thr Ala Ser Glu Ser
 225                 230                 235                



      <210> 605
      <211> 148
      <212> PRT
      <213> Homo sapiens


      <400> 605
 Met Ala Ser Gly Asn Ala Arg Ile Gly Lys Thr Ala Pro Asp Phe Lys
   1               5                  10                  15    
 Asp Thr Ala Val Val Asp Gly Ala Phe Lys Glu Val Lys Leu Ser Asp
              20                  25                  30        
 Tyr Lys Gly Lys Ile Asn Thr Pro Arg Lys Glu Gly Gly Leu Gly Pro
          35                  40                  45            
 Leu Asn Ile His Leu Leu Ala Asp Val Thr Arg Arg Leu Ser Glu Asp
      50                  55                  60                
 Tyr Gly Val Leu Lys Thr Asp Glu Gly Ile Ala Tyr Arg Gly Leu Phe
  65                  70                  75                  80
 Ile Ile Asp Gly Lys Gly Val Leu Arg Gln Ile Thr Val Asn Asp Leu
                  85                  90                  95    
 Pro Val Gly Arg Ser Val Asp Glu Ala Leu Arg Leu Val Gln Ala Phe
             100                 105                 110        
 Gln Tyr Thr Asp Glu His Gly Glu Val Cys Pro Ala Gly Trp Lys Pro
         115                 120                 125            
 Gly Ser Asp Thr Ile Lys Pro Asn Val Asp Asp Ser Lys Glu Tyr Phe
     130                 135                 140                
 Ser Lys His Asn
 145            



      <210> 606
      <211> 217
      <212> PRT
      <213> Homo sapiens


      <400> 606
 Met Ser Leu Val Gly Gly Phe Pro His His Pro Val Val His His Glu
   1               5                  10                  15    
 Gly Tyr Pro Phe Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala
              20                  25                  30        
 Ser Arg Cys Ser His Glu Glu Asn Pro Tyr Phe His Gly Trp Leu Ile
          35                  40                  45            
 Gly His Pro Glu Met Ser Pro Pro Asp Tyr Ser Met Ala Leu Ser Tyr
      50                  55                  60                
 Ser Pro Glu Tyr Ala Ser Gly Ala Ala Gly Leu Asp His Ser His Tyr
  65                  70                  75                  80
 Gly Gly Val Pro Pro Gly Ala Gly Pro Pro Gly Leu Gly Gly Pro Arg
                  85                  90                  95    
 Pro Val Lys Arg Arg Gly Thr Ala Asn Arg Lys Glu Arg Arg Arg Thr
             100                 105                 110        
 Gln Ser Ile Asn Ser Ala Phe Ala Glu Leu Arg Glu Cys Ile Pro Asn
         115                 120                 125            
 Val Pro Ala Asp Thr Lys Leu Ser Lys Ile Lys Thr Leu Arg Leu Ala
     130                 135                 140                
 Thr Ser Tyr Ile Ala Tyr Leu Met Asp Leu Leu Ala Lys Asp Asp Gln
 145                 150                 155                 160
 Asn Gly Glu Ala Glu Ala Phe Lys Ala Glu Ile Lys Lys Thr Asp Val
                 165                 170                 175    
 Lys Glu Glu Lys Arg Lys Lys Glu Leu Asn Glu Ile Leu Lys Ser Thr
             180                 185                 190        
 Val Ser Ser Asn Asp Lys Lys Thr Lys Gly Arg Thr Gly Trp Pro Gln
         195                 200                 205            
 His Val Trp Ala Leu Glu Leu Lys Gln
     210                 215        



      <210> 607
      <211> 135
      <212> PRT
      <213> Homo sapiens


      <400> 607
 Met Ser Gly Leu Arg Val Tyr Ser Thr Ser Val Thr Gly Ser Arg Glu
   1               5                  10                  15    
 Ile Lys Ser Gln Gln Ser Glu Val Thr Arg Ile Leu Asp Gly Lys Arg
              20                  25                  30        
 Ile Gln Tyr Gln Leu Val Asp Ile Ser Gln Asp Asn Ala Leu Arg Asp
          35                  40                  45            
 Glu Met Arg Ala Leu Ala Gly Asn Pro Lys Ala Thr Pro Pro Gln Ile
      50                  55                  60                
 Val Asn Gly Asp Gln Tyr Cys Gly Tyr Gly Leu Gly Asp Gly Gly Val
  65                  70                  75                  80
 Gly Gly Val Leu Glu Glu Asp Ser Ser Gln Gly His Ile Val Pro Gln
                  85                  90                  95    
 Ser Thr Cys Gly Pro Leu His Ser Gly Asp His Pro Ser Pro Pro Leu
             100                 105                 110        
 Leu Gln Asp Tyr Glu Leu Phe Val Glu Ala Val Glu Gln Asn Thr Leu
         115                 120                 125            
 Gln Glu Phe Leu Lys Leu Ala
     130                 135



      <210> 608
      <211> 181
      <212> PRT
      <213> Homo sapiens


      <400> 608
 Met Ala Thr Lys Ile Asp Lys Glu Ala Cys Arg Ala Ala Tyr Asn Leu
   1               5                  10                  15    
 Val Arg Asp Asp Gly Ser Ala Val Ile Trp Val Thr Phe Lys Tyr Asp
              20                  25                  30        
 Gly Ser Thr Ile Val Pro Gly Glu Gln Gly Ala Glu Tyr Gln His Phe
          35                  40                  45            
 Ile Gln Gln Cys Thr Asp Asp Val Arg Leu Phe Ala Phe Val Arg Phe
      50                  55                  60                
 Thr Thr Gly Asp Ala Met Ser Lys Arg Ser Lys Phe Ala Leu Ile Thr
  65                  70                  75                  80
 Trp Ile Gly Glu Asn Val Ser Gly Leu Gln Arg Ala Lys Thr Gly Thr
                  85                  90                  95    
 Asp Lys Thr Leu Val Lys Glu Val Val Gln Asn Phe Ala Lys Glu Phe
             100                 105                 110        
 Val Ile Ser Asp Arg Lys Glu Leu Glu Glu Asp Leu Ile Lys Ser Glu
         115                 120                 125            
 Leu Lys Lys Ala Gly Gly Ala Asn Tyr Asp Ala Gln Thr Asp Val Thr
     130                 135                 140                
 Pro Ala Pro Gly Thr Pro Ala Leu Ala Lys Val Ile Cys Leu Leu Pro
 145                 150                 155                 160
 Gly Gly Arg Gly Pro Pro Ala Ser Gly Thr Ser Pro Pro Ala His Gln
                 165                 170                 175    
 Ala Glu Glu Lys Pro
             180    



      <210> 609
      <211> 272
      <212> PRT
      <213> Homo sapiens


      <400> 609
 Met Leu Gln Leu Arg Asp Ser Val Asp Ser Ala Gly Thr Ser Pro Thr
   1               5                  10                  15    
 Ala Val Leu Ala Ala Gly Glu Glu Val Gly Ala Gly Gly Gly Pro Gly
              20                  25                  30        
 Gly Gly Arg Pro Gly Ala Gly Thr Pro Leu Arg Gln Thr Leu Trp Pro
          35                  40                  45            
 Leu Ser Ile His Asp Pro Thr Arg Arg Ala Arg Val Lys Glu Tyr Phe
      50                  55                  60                
 Val Phe Arg Pro Gly Ser Ile Glu Gln Ala Val Glu Glu Ile Arg Val
  65                  70                  75                  80
 Val Val Arg Pro Val Glu Asp Gly Glu Ile Gln Gly Val Trp Leu Leu
                  85                  90                  95    
 Thr Glu Val Asp His Trp Asn Asn Glu Lys Glu Arg Leu Val Leu Val
             100                 105                 110        
 Thr Glu Gln Ser Leu Leu Ile Cys Lys Tyr Asp Phe Ile Ser Leu Gln
         115                 120                 125            
 Cys Gln Gln Val Val Arg Ile Ala Leu Asn Ala Val Asp Thr Ile Ser
     130                 135                 140                
 Tyr Gly Glu Phe Gln Phe Pro Pro Lys Ser Leu Asn Lys Arg Glu Gly
 145                 150                 155                 160
 Phe Gly Ile Arg Ile Gln Trp Asp Lys Gln Ser Arg Pro Ser Phe Ile
                 165                 170                 175    
 Asn Arg Trp Asn Pro Trp Ser Thr Asn Val Pro Tyr Ala Thr Phe Thr
             180                 185                 190        
 Glu His Pro Met Ala Gly Ala Asp Glu Lys Thr Ala Ser Leu Cys Gln
         195                 200                 205            
 Leu Glu Ser Phe Lys Ala Leu Leu Ile Gln Ala Val Lys Lys Ala Gln
     210                 215                 220                
 Lys Glu Ser Pro Leu Pro Gly Gln Ala Asn Gly Val Leu Ile Leu Glu
 225                 230                 235                 240
 Arg Pro Leu Leu Ile Glu Thr Tyr Val Gly Leu Met Ser Phe Ile Asn
                 245                 250                 255    
 Asn Glu Ala Lys Leu Gly Tyr Ser Met Thr Arg Gly Lys Ile Gly Phe
             260                 265                 270        





      <210> 610
      <211> 590
      <212> PRT
      <213> Homo sapiens


      <400> 610
 Met Glu Gln Glu Lys Phe Asp Leu Gln Lys Gln His Thr Glu Asn Ile
   1               5                  10                  15    
 Gln Glu Leu Leu Glu Asp Thr Asn Val Arg Leu Asn Lys Met Glu Ser
              20                  25                  30        
 Glu Tyr Met Ala Gln Thr Gln Ser Thr Asn His Met Ile Lys Glu Leu
          35                  40                  45            
 Glu Ala Arg Val Gln Gln Leu Thr Gly Glu Ala Glu Asn Ser Asn Leu
      50                  55                  60                
 Gln Arg Gln Lys Leu Ile Gln Glu Lys Ala Glu Leu Glu Arg Cys Tyr
  65                  70                  75                  80
 Gln Ile Thr Cys Ser Glu Leu Gln Glu Val Lys Ala Arg Arg Asn Thr
                  85                  90                  95    
 Leu His Lys Glu Lys Asp His Leu Val Asn Asp Tyr Glu Gln Asn Met
             100                 105                 110        
 Lys Leu Leu Gln Thr Lys Tyr Asp Ala Asp Ile Asn Leu Leu Lys Gln
         115                 120                 125            
 Glu His Ala Leu Ser Ala Ser Lys Ala Ser Ser Met Ile Glu Glu Leu
     130                 135                 140                
 Glu Gln Asn Val Cys Gln Leu Lys Gln Gln Leu Gln Glu Ser Glu Leu
 145                 150                 155                 160
 Gln Arg Lys Gln Gln Leu Arg Asp Gln Glu Asn Lys Phe Gln Met Glu
                 165                 170                 175    
 Lys Ser His Leu Lys His Ile Tyr Glu Lys Lys Ala His Asp Leu Gln
             180                 185                 190        
 Ser Glu Leu Asp Lys Gly Lys Glu Asp Thr Gln Lys Lys Ile His Lys
         195                 200                 205            
 Phe Glu Glu Ala Leu Lys Glu Lys Glu Glu Gln Leu Thr Arg Val Thr
     210                 215                 220                
 Glu Val Gln Arg Leu Gln Ala Gln Gln Ala Asp Ala Ala Leu Glu Glu
 225                 230                 235                 240
 Phe Lys Arg Gln Val Glu Leu Asn Ser Glu Lys Val Tyr Ala Glu Met
                 245                 250                 255    
 Lys Glu Gln Met Glu Lys Val Glu Ala Asp Leu Thr Arg Ser Lys Ser
             260                 265                 270        
 Leu Arg Glu Lys Gln Ser Lys Glu Phe Leu Trp Gln Leu Glu Asp Ile
         275                 280                 285            
 Arg Gln Arg Tyr Glu Gln Gln Ile Val Glu Leu Lys Leu Glu His Glu
     290                 295                 300                
 Gln Glu Lys Thr His Leu Leu Gln Gln His Asn Ala Glu Lys Asp Ser
 305                 310                 315                 320
 Leu Val Arg Asp His Glu Arg Glu Ile Glu Asn Leu Glu Lys Gln Leu
                 325                 330                 335    
 Arg Ala Ala Asn Met Glu His Glu Asn Gln Ile Gln Glu Phe Lys Lys
             340                 345                 350        
 Arg Asp Ala Gln Val Ile Ala Asp Met Glu Ala Gln Val His Lys Leu
         355                 360                 365            
 Arg Glu Glu Leu Ile Asn Val Asn Ser Gln Arg Lys Gln Gln Leu Val
     370                 375                 380                
 Glu Leu Gly Leu Leu Arg Glu Glu Glu Lys Gln Arg Ala Thr Arg Glu
 385                 390                 395                 400
 His Glu Ile Val Val Asn Lys Leu Lys Ala Glu Ser Glu Lys Met Lys
                 405                 410                 415    
 Ile Glu Leu Lys Lys Thr His Ala Ala Glu Thr Glu Met Thr Leu Glu
             420                 425                 430        
 Lys Ala Asn Ser Lys Leu Lys Gln Ile Glu Lys Glu Tyr Thr Gln Lys
         435                 440                 445            
 Leu Ala Lys Ser Ser Gln Ile Ile Ala Glu Leu Gln Thr Thr Ile Ser
     450                 455                 460                
 Ser Leu Lys Glu Glu Asn Ser Gln Gln Gln Leu Ala Ala Glu Arg Arg
 465                 470                 475                 480
 Leu Gln Asp Val Arg Gln Lys Phe Glu Asp Glu Lys Lys Gln Leu Ile
                 485                 490                 495    
 Arg Asp Asn Asp Gln Ala Ile Lys Val Leu Gln Asp Glu Leu Glu Asn
             500                 505                 510        
 Arg Ser Asn Gln Val Arg Cys Ala Glu Lys Lys Leu Gln His Lys Glu
         515                 520                 525            
 Leu Glu Ser Gln Glu Gln Ile Thr Tyr Ile Arg Gln Glu Tyr Glu Thr
     530                 535                 540                
 Lys Leu Lys Gly Leu Met Pro Ala Ser Leu Arg Gln Glu Leu Glu Asp
 545                 550                 555                 560
 Thr Ile Ser Ser Leu Lys Ser Gln Val Asn Phe Leu Gln Lys Arg Ala
                 565                 570                 575    
 Ser Ile Leu Gln Glu Glu Leu Thr Thr Tyr Gln Gly Arg Arg
             580                 585                 590



      <210> 611
      <211> 141
      <212> PRT
      <213> Homo sapiens


      <400> 611
 Met Ala Asp Glu Glu Lys Leu Pro Pro Gly Trp Glu Lys Arg Met Ser
   1               5                  10                  15    
 Arg Pro Ser Gly Arg Gly Tyr Tyr Phe Asn His Ile Thr Asn Pro Ser
              20                  25                  30        
 Gln Trp Glu Arg Pro Ser Gly Asn Ser Ser Ser Gly Gly Lys Ile Trp
          35                  40                  45            
 Gln Gly Glu Pro Ala Arg Glu Ile Thr Arg Thr Lys Glu Glu Ala Leu
      50                  55                  60                
 Glu Leu Ile Ser Gly Tyr Ile Gln Lys Ile Lys Ala Gly Glu Lys Asp
  65                  70                  75                  80
 Phe Glu Ser Pro Ala Ser Gln Phe Ser Asp Cys Ser Ser Ala Lys Ala
                  85                  90                  95    
 Arg Gly Asp Leu Gly Ala Phe Ser Lys Gly Gln Met Gln Lys Pro Phe
             100                 105                 110        
 Glu Asp Pro Trp Phe Ala Arg Arg Thr Gly Glu Met Ser Gly Thr Val
         115                 120                 125            
 Phe Thr Asp Ser Gly Ile His Val Ile Val Arg Thr Glu
     130                 135                 140    



      <210> 612
      <211> 173
      <212> PRT
      <213> Homo sapiens


      <400> 612
 Met Ala Pro Lys Lys Pro Glu Pro Lys Lys Glu Ala Ala Lys Pro Ala
   1               5                  10                  15    
 Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Glu
              20                  25                  30        
 Ala Pro Lys Glu Pro Ala Phe Asp Pro Lys Ser Val Lys Ile Asp Phe
          35                  40                  45            
 Thr Ala Asp Gln Ile Glu Glu Phe Lys Glu Ala Phe Ser Leu Phe Asp
      50                  55                  60                
 Arg Thr Pro Thr Gly Glu Met Lys Ile Thr Tyr Gly Gln Cys Gly Asp
  65                  70                  75                  80
 Val Leu Arg Ala Leu Gly Gln Asn Pro Thr Asn Ala Glu Val Leu Arg
                  85                  90                  95    
 Val Leu Gly Lys Pro Lys Pro Glu Glu Met Asn Val Lys Met Leu Asp
             100                 105                 110        
 Phe Glu Thr Phe Leu Pro Ile Leu Gln His Ile Ser Arg Asn Lys Glu
         115                 120                 125            
 Gln Gly Thr Tyr Glu Asp Phe Val Glu Gly Leu Arg Val Phe Asp Lys
     130                 135                 140                
 Glu Ser Asn Gly Thr Val Met Gly Gly Gln Glu Asp Ala Asn Gly Cys
 145                 150                 155                 160
 Ile Asn Tyr Glu Ala Phe Val Lys His Ile Met Ser Gly
                 165                 170            



      <210> 613
      <211> 335
      <212> PRT
      <213> Homo sapiens


      <400> 613
 Met Gly Val Ser Phe Val Ala Pro Gly Gly Asn Pro Gly Pro Thr Pro
   1               5                  10                  15    
 Asn Ser Thr Pro Pro Ile Thr Pro Arg Ser Leu Asp Arg Ile Arg Pro
              20                  25                  30        
 Ile Leu Val Leu Met Val Asp Lys Lys Leu Val Val Val Phe Gly Gly
          35                  40                  45            
 Thr Gly Ala Gln Gly Gly Ser Val Ala Arg Thr Leu Leu Glu Asp Gly
      50                  55                  60                
 Thr Phe Lys Val Arg Val Val Thr Arg Asn Pro Arg Lys Lys Ala Ala
  65                  70                  75                  80
 Lys Glu Leu Arg Leu Gln Gly Ala Glu Val Val Gln Gly Asp Gln Asp
                  85                  90                  95    
 Asp Gln Val Ile Met Glu Leu Ala Leu Asn Gly Ala Tyr Ala Thr Phe
             100                 105                 110        
 Ile Val Thr Asn Tyr Trp Glu Ser Cys Ser Gln Glu Gln Glu Val Lys
         115                 120                 125            
 Gln Gly Lys Leu Leu Ala Asp Leu Ala Arg Arg Leu Gly Leu His Tyr
     130                 135                 140                
 Val Val Tyr Ser Gly Leu Glu Asn Ile Lys Lys Leu Thr Ala Gly Arg
 145                 150                 155                 160
 Leu Ala Ala Ala His Phe Asp Gly Lys Gly Glu Val Glu Glu Tyr Phe
                 165                 170                 175    
 Arg Asp Ile Gly Val Pro Met Thr Ser Val Arg Leu Pro Cys Tyr Phe
             180                 185                 190        
 Glu Asn Leu Leu Ser His Phe Leu Pro Gln Lys Ala Pro Asp Gly Lys
         195                 200                 205            
 Ser Tyr Leu Leu Ser Leu Pro Thr Gly Asp Val Pro Met Asp Gly Met
     210                 215                 220                
 Ser Val Ser Asp Leu Gly Pro Val Val Leu Ser Leu Leu Lys Met Pro
 225                 230                 235                 240
 Glu Lys Tyr Val Gly Gln Asn Ile Gly Leu Ser Thr Cys Arg His Thr
                 245                 250                 255    
 Ala Glu Glu Tyr Ala Ala Leu Leu Thr Lys His Thr Arg Lys Val Val
             260                 265                 270        
 His Asp Ala Lys Met Thr Pro Glu Asp Tyr Glu Lys Leu Gly Phe Pro
         275                 280                 285            
 Gly Ala Arg Asp Leu Ala Asn Met Phe Arg Phe Tyr Ala Leu Arg Pro
     290                 295                 300                
 Asp Arg Asp Ile Glu Leu Thr Leu Arg Leu Asn Pro Lys Ala Leu Thr
 305                 310                 315                 320
 Leu Asp Gln Trp Leu Glu Gln His Lys Gly Asp Phe Asn Leu Leu
                 325                 330                 335



      <210> 614
      <211> 501
      <212> PRT
      <213> Homo sapiens


      <400> 614
 Met Gln Val Cys Ser Gln Pro Gln Arg Gly Cys Val Arg Glu Gln Ser
   1               5                  10                  15    
 Ala Ile Asn Thr Ala Pro Pro Ser Ala His Asn Ala Ala Ser Pro Gly
              20                  25                  30        
 Gly Ala Arg Gly His Arg Val Pro Leu Thr Glu Ala Cys Lys Asp Ser
          35                  40                  45            
 Arg Ile Gly Gly Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu
      50                  55                  60                
 Leu Thr Trp Glu Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp
  65                  70                  75                  80
 Asn Glu Leu Gln Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys
                  85                  90                  95    
 Glu Ile Gln Asn Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile
             100                 105                 110        
 Glu Lys Thr Asn Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu
         115                 120                 125            
 Ala Lys Lys Lys Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu
     130                 135                 140                
 Thr Lys Leu Lys Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala
 145                 150                 155                 160
 Leu Trp Glu Glu Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe
                 165                 170                 175    
 Tyr Ala Arg Val Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu
             180                 185                 190        
 Glu Glu Phe Leu Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly
         195                 200                 205            
 Asp Arg Ile Asp Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met
     210                 215                 220                
 Leu Asp Val Met Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp
 225                 230                 235                 240
 Glu Leu Phe Gln Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr
                 245                 250                 255    
 His Tyr Leu Pro Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe
             260                 265                 270        
 Pro Lys Ser Arg Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu
         275                 280                 285            
 Pro Leu Asn Phe His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His
     290                 295                 300                
 Glu Ala Gln Gln Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln
 305                 310                 315                 320
 His Pro Pro Thr Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val
                 325                 330                 335    
 Cys Arg Glu Ile Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp
             340                 345                 350        
 Gln Cys Asp Lys Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn
         355                 360                 365            
 Asn Pro Ser Gln Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln
     370                 375                 380                
 Val Ala Glu Arg Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr
 385                 390                 395                 400
 Gln Trp Lys Met Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu
                 405                 410                 415    
 Gln Phe Asn Trp Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp
             420                 425                 430        
 Gln Tyr Tyr Leu Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser
         435                 440                 445            
 Asp Val Pro Ser Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser
     450                 455                 460                
 Asp Pro Ile Thr Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro
 465                 470                 475                 480
 Lys Phe Met Glu Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys
                 485                 490                 495    
 Lys His Arg Glu Glu
             500    



      <210> 615
      <211> 86
      <212> PRT
      <213> Homo sapiens


      <400> 615
 Met Asn Ala Pro Pro Ala Phe Glu Ser Phe Leu Leu Phe Glu Gly Glu
   1               5                  10                  15    
 Lys Gln Leu Leu Lys Asp Pro Gln Val Leu Phe Ala Gly Tyr Lys Val
              20                  25                  30        
 Pro His Pro Leu Glu His Lys Ile Ile Ile Arg Val Gln Thr Thr Pro
          35                  40                  45            
 Asp Tyr Ser Pro Gln Glu Ala Phe Thr Asn Ala Ile Thr Asp Leu Ile
      50                  55                  60                
 Ser Glu Leu Ser Leu Leu Glu Glu Arg Phe Arg Val Ala Ile Lys Asp
  65                  70                  75                  80
 Lys Gln Glu Gly Ile Glu
                  85    



      <210> 616
      <211> 514
      <212> PRT
      <213> Homo sapiens


      <400> 616
 Met Arg Leu Glu Trp Gly Pro Arg Pro Ala Ala Leu Pro Trp Pro Ala
   1               5                  10                  15    
 Gly Met Cys Ala Ala Glu Arg Ala Glu Gly Ala Phe Thr Leu Gln Ser
              20                  25                  30        
 Val Ala Gln Pro Met Arg Pro Ile Ala Ser Thr Ala Thr Lys Cys Gly
          35                  40                  45            
 Asn Cys Gly Pro Gly Tyr Ser Thr Pro Leu Glu Ala Met Lys Gly Pro
      50                  55                  60                
 Arg Glu Glu Ile Val Tyr Leu Pro Cys Ile Tyr Arg Asn Thr Gly Thr
  65                  70                  75                  80
 Glu Ala Pro Asp Tyr Leu Ala Thr Val Asp Val Asp Pro Lys Ser Pro
                  85                  90                  95    
 Gln Tyr Cys Gln Val Ile His Arg Leu Pro Met Pro Asn Leu Lys Asp
             100                 105                 110        
 Glu Leu His Asn Ser Gly Trp Asn Thr Cys Ser Ser Cys Phe Gly Asp
         115                 120                 125            
 Ser Thr Lys Ser Arg Thr Lys Leu Val Leu Pro Ser Leu Ile Ser Ser
     130                 135                 140                
 Arg Ile Tyr Val Val Asp Val Gly Ser Glu Pro Arg Ala Pro Lys Leu
 145                 150                 155                 160
 His Lys Val Ile Glu Pro Lys Asp Ile His Ala Lys Cys Glu Leu Ala
                 165                 170                 175    
 Phe Leu His Thr Ser His Cys Leu Ala Ser Gly Glu Val Met Ile Ser
             180                 185                 190        
 Ser Leu Gly Asp Val Lys Gly Asn Gly Lys Gly Gly Phe Val Leu Leu
         195                 200                 205            
 Asp Gly Glu Thr Phe Glu Val Lys Gly Thr Trp Glu Arg Pro Gly Gly
     210                 215                 220                
 Ala Ala Pro Leu Gly Tyr Asp Phe Trp Tyr Gln Pro Arg His Asn Val
 225                 230                 235                 240
 Met Ile Ser Thr Glu Trp Ala Ala Pro Asn Val Leu Arg Asp Gly Phe
                 245                 250                 255    
 Asn Pro Ala Asp Val Glu Ala Gly Leu Tyr Gly Ser His Leu Tyr Val
             260                 265                 270        
 Trp Asp Trp Gln Arg His Glu Ile Val Gln Thr Leu Ser Leu Lys Asp
         275                 280                 285            
 Gly Leu Ile Pro Leu Glu Ile Arg Phe Leu His Asn Pro Asp Ala Ala
     290                 295                 300                
 Gln Gly Phe Val Gly Cys Ala Leu Ser Ser Thr Ile Gln Arg Phe Tyr
 305                 310                 315                 320
 Lys Asn Glu Gly Gly Thr Trp Ser Val Glu Lys Val Ile Gln Val Pro
                 325                 330                 335    
 Pro Lys Lys Val Lys Gly Trp Leu Leu Pro Glu Met Pro Gly Leu Ile
             340                 345                 350        
 Thr Asp Ile Leu Leu Ser Leu Asp Asp Arg Phe Leu Tyr Phe Ser Asn
         355                 360                 365            
 Trp Leu His Gly Asp Leu Arg Gln Tyr Asp Ile Ser Asp Pro Gln Arg
     370                 375                 380                
 Pro Arg Leu Thr Gly Gln Leu Phe Leu Gly Gly Ser Ile Val Lys Gly
 385                 390                 395                 400
 Gly Pro Val Gln Val Leu Glu Asp Glu Glu Leu Lys Ser Gln Pro Glu
                 405                 410                 415    
 Pro Leu Val Val Lys Gly Lys Arg Val Ala Gly Gly Pro Gln Met Ile
             420                 425                 430        
 Gln Leu Ser Leu Asp Gly Lys Arg Leu Tyr Ile Thr Thr Ser Leu Tyr
         435                 440                 445            
 Ser Ala Trp Glu Lys Gln Phe Tyr Pro Asp Leu Ile Arg Glu Gly Ser
     450                 455                 460                
 Val Met Leu Gln Val Asp Val Asp Thr Val Lys Gly Gly Leu Lys Leu
 465                 470                 475                 480
 Asn Pro Asn Cys Leu Val Asp Phe Gly Lys Glu Pro Leu Gly Pro Ala
                 485                 490                 495    
 Leu Ala His Glu Leu Arg Tyr Pro Gly Gly Asp Cys Ser Ser Asp Ile
             500                 505                 510        
 Trp Ile
        



      <210> 617
      <211> 625
      <212> PRT
      <213> Homo sapiens


      <400> 617
 Met Lys Cys Lys Arg Ala Pro Tyr Lys Ser Tyr Arg Asn Ser Ser Tyr
   1               5                  10                  15    
 Glu Asn Ala Arg Glu Asn Ser Gln Met Asn Glu Ser Ala Pro Gly Thr
              20                  25                  30        
 Tyr Val Val Gln Asn Pro His Ser Ser Glu Leu Pro Thr Leu Asn Phe
          35                  40                  45            
 Gln Asp Thr Val Asn Thr Leu Thr Asn Ser Pro Ala Ile Pro Leu Glu
      50                  55                  60                
 Thr Ser Ala Cys Gln Asp Ile Pro Thr Ser Ala Asn Val Gln Asn Ala
  65                  70                  75                  80
 Glu Gly Thr Lys Trp Gly Glu Glu Ala Leu Lys Met Asp Leu Asp Asn
                  85                  90                  95    
 Asn Phe Tyr Ser Thr Glu Val Ser Val Ser Ser Thr Glu Asn Ala Val
             100                 105                 110        
 Ser Ser Asp Leu Arg Ala Gly Asp Val Pro Val Leu Ser Leu Ser Asn
         115                 120                 125            
 Ser Ser Glu Asn Ala Ala Ser Val Ile Ser Tyr Ser Gly Ser Ala Pro
     130                 135                 140                
 Ser Val Ile Val His Ser Ser Gln Phe Ser Ser Val Ile Met His Ser
 145                 150                 155                 160
 Asn Ala Ile Ala Ala Met Thr Ser Ser Asn His Arg Ala Phe Ser Asp
                 165                 170                 175    
 Pro Ala Val Ser Gln Ser Leu Lys Asp Asp Ser Lys Pro Glu Pro Asp
             180                 185                 190        
 Lys Val Gly Arg Phe Ala Ser Arg Pro Lys Ser Ile Lys Glu Lys Lys
         195                 200                 205            
 Lys Thr Thr Ser His Thr Arg Gly Glu Ile Pro Glu Glu Ser Asn Tyr
     210                 215                 220                
 Val Ala Asp Pro Gly Gly Ser Leu Ser Lys Thr Thr Asn Ile Ala Glu
 225                 230                 235                 240
 Glu Thr Ser Lys Ile Glu Thr Tyr Ile Ala Lys Pro Ala Leu Pro Gly
                 245                 250                 255    
 Thr Ser Thr Asn Ser Asn Val Ala Pro Leu Cys Gln Ile Thr Val Lys
             260                 265                 270        
 Ile Gly Asn Glu Ala Ile Val Lys Arg His Ile Leu Gly Ser Lys Leu
         275                 280                 285            
 Phe Tyr Lys Arg Gly Arg Arg Pro Lys Tyr Gln Met Gln Glu Glu Pro
     290                 295                 300                
 Leu Pro Gln Gly Asn Asp Pro Glu Pro Ser Gly Asp Ser Pro Leu Gly
 305                 310                 315                 320
 Leu Cys Gln Ser Glu Cys Met Glu Met Ser Glu Val Phe Asp Asp Ala
                 325                 330                 335    
 Ser Asp Gln Asp Ser Thr Asp Lys Pro Trp Arg Pro Tyr Tyr Asn Tyr
             340                 345                 350        
 Lys Pro Lys Lys Lys Ser Arg Gln Leu Lys Lys Met Arg Lys Val Asn
         355                 360                 365            
 Trp Arg Lys Glu His Gly Asn Arg Ser Pro Ser His Lys Cys Lys Tyr
     370                 375                 380                
 Pro Ala Glu Leu Asp Cys Ala Val Gly Lys Ala Pro Gln Asp Lys Pro
 385                 390                 395                 400
 Phe Glu Glu Glu Glu Thr Lys Glu Met Pro Lys Leu Gln Cys Glu Leu
                 405                 410                 415    
 Cys Asp Gly Asp Lys Ala Val Gly Ala Gly Asn Gln Gly Arg Pro His
             420                 425                 430        
 Arg His Leu Thr Ser Arg Pro Tyr Ala Cys Glu Leu Cys Ala Lys Gln
         435                 440                 445            
 Phe Gln Ser Pro Ser Thr Leu Lys Met His Met Arg Cys His Thr Gly
     450                 455                 460                
 Glu Lys Pro Tyr Gln Cys Lys Thr Cys Gly Arg Cys Phe Ser Val Gln
 465                 470                 475                 480
 Gly Asn Leu Gln Lys His Glu Arg Ile His Leu Gly Leu Lys Glu Phe
                 485                 490                 495    
 Val Cys Gln Tyr Cys Asn Lys Ala Phe Thr Leu Asn Glu Thr Leu Lys
             500                 505                 510        
 Ile His Glu Arg Ile His Thr Gly Glu Lys Arg Tyr His Cys Gln Phe
         515                 520                 525            
 Cys Phe Gln Arg Phe Leu Tyr Leu Ser Thr Lys Arg Asn His Glu Gln
     530                 535                 540                
 Arg His Ile Arg Glu His Asn Gly Lys Gly Tyr Ala Cys Phe Gln Cys
 545                 550                 555                 560
 Pro Lys Ile Cys Lys Thr Ala Ala Ala Leu Gly Met His Gln Lys Lys
                 565                 570                 575    
 His Leu Phe Lys Ser Pro Ser Gln Gln Glu Lys Ile Gly Asp Val Cys
             580                 585                 590        
 His Glu Asn Ser Asn Pro Leu Glu Asn Gln His Phe Ile Gly Ser Glu
         595                 600                 605            
 Asp Asn Asp Gln Lys Asp Asn Ile Gln Thr Gly Val Glu Asn Val Val
     610                 615                 620                
 Leu
 625



      <210> 618
      <211> 533
      <212> PRT
      <213> Homo sapiens


      <400> 618
 Met Gly Ser Val Gly Ser Leu Leu Glu Arg Gln Asp Phe Ser Pro Glu
   1               5                  10                  15    
 Glu Leu Arg Ala Ala Leu Ala Gly Ser Arg Gly Ser Arg Gln Pro Asp
              20                  25                  30        
 Gly Leu Leu Arg Lys Gly Leu Gly Gln Arg Glu Phe Leu Ser Tyr Leu
          35                  40                  45            
 His Leu Pro Lys Lys Asp Ser Lys Ser Thr Lys Asn Thr Lys Arg Ala
      50                  55                  60                
 Pro Arg Asn Glu Pro Ala Asp Tyr Ala Thr Leu Tyr Tyr Arg Glu His
  65                  70                  75                  80
 Ser Arg Ala Gly Asp Phe Ser Lys Thr Ser Leu Pro Glu Arg Gly Arg
                  85                  90                  95    
 Phe Asp Lys Cys Arg Ile Arg Pro Ser Val Phe Lys Pro Thr Ala Gly
             100                 105                 110        
 Asn Gly Lys Gly Phe Leu Ser Met Gln Ser Leu Ala Ser His Lys Gly
         115                 120                 125            
 Gln Lys Leu Trp Arg Ser Asn Gly Ser Leu His Thr Leu Ala Cys His
     130                 135                 140                
 Pro Pro Leu Ser Pro Gly Pro Arg Ala Ser Gln Ala Arg Ala Gln Leu
 145                 150                 155                 160
 Leu His Ala Leu Ser Leu Asp Glu Gly Gly Pro Glu Pro Glu Pro Ser
                 165                 170                 175    
 Leu Ser Asp Ser Ser Ser Gly Gly Ser Phe Gly Arg Ser Pro Gly Thr
             180                 185                 190        
 Gly Pro Ser Pro Phe Ser Ser Ser Leu Gly His Leu Asn His Leu Gly
         195                 200                 205            
 Gly Ser Leu Asp Arg Ala Ser Gln Gly Pro Lys Glu Ala Gly Pro Pro
     210                 215                 220                
 Ala Val Leu Ser Cys Leu Pro Glu Pro Pro Pro Pro Tyr Glu Phe Ser
 225                 230                 235                 240
 Cys Ser Ser Ala Glu Glu Met Gly Ala Val Leu Pro Glu Thr Cys Glu
                 245                 250                 255    
 Glu Leu Lys Arg Gly Leu Gly Asp Glu Asp Gly Ser Asn Pro Phe Thr
             260                 265                 270        
 Gln Val Leu Glu Glu Arg Gln Arg Leu Trp Leu Ala Glu Leu Lys Arg
         275                 280                 285            
 Leu Tyr Val Glu Arg Leu His Glu Val Thr Gln Lys Ala Glu Arg Ser
     290                 295                 300                
 Glu Arg Asn Leu Gln Leu Gln Leu Phe Met Ala Gln Gln Glu Gln Arg
 305                 310                 315                 320
 Arg Leu Arg Lys Glu Leu Arg Ala Gln Gln Gly Leu Ala Pro Glu Pro
                 325                 330                 335    
 Arg Ala Pro Gly Thr Leu Pro Glu Ala Asp Pro Ser Ala Arg Pro Glu
             340                 345                 350        
 Glu Glu Ala Arg Trp Glu Val Cys Gln Lys Thr Ala Glu Ile Ser Leu
         355                 360                 365            
 Leu Lys Gln Gln Leu Arg Glu Ala Gln Ala Glu Leu Ala Gln Lys Leu
     370                 375                 380                
 Ala Glu Ile Phe Ser Leu Lys Thr Gln Leu Arg Gly Ser Arg Ala Gln
 385                 390                 395                 400
 Ala Gln Ala Gln Asp Ala Glu Leu Val Arg Leu Arg Glu Ala Val Arg
                 405                 410                 415    
 Ser Leu Gln Glu Gln Ala Pro Arg Glu Glu Ala Pro Gly Ser Cys Glu
             420                 425                 430        
 Thr Asp Asp Cys Lys Ser Arg Gly Leu Leu Gly Glu Ala Gly Gly Ser
         435                 440                 445            
 Glu Ala Arg Asp Ser Ala Glu Gln Leu Arg Ala Glu Leu Leu Gln Glu
     450                 455                 460                
 Arg Leu Arg Gly Gln Glu Gln Ala Leu Arg Phe Glu Gln Glu Arg Arg
 465                 470                 475                 480
 Thr Trp Gln Glu Glu Lys Glu Arg Val Leu Arg Tyr Gln Arg Glu Ile
                 485                 490                 495    
 Gln Gly Gly Tyr Met Asp Met Tyr Arg Arg Asn Gln Ala Leu Glu Gln
             500                 505                 510        
 Glu Leu Arg Ala Leu Arg Glu Pro Pro Thr Pro Trp Ser Pro Arg Leu
         515                 520                 525            
 Glu Ser Ser Lys Ile
     530            



      <210> 619
      <211> 1068
      <212> PRT
      <213> Homo sapiens


      <400> 619
 Met Phe Thr Leu Ser Gln Thr Ser Arg Ala Trp Phe Ile Asp Arg Ala
   1               5                  10                  15    
 Arg Gln Ala Arg Glu Glu Arg Leu Val Gln Lys Glu Arg Glu Arg Ala
              20                  25                  30        
 Ala Val Val Ile Gln Ala His Val Arg Ser Phe Leu Cys Arg Ser Arg
          35                  40                  45            
 Leu Gln Arg Asp Ile Arg Arg Glu Ile Asp Asp Phe Phe Lys Ala Asp
      50                  55                  60                
 Asp Pro Glu Ser Thr Lys Arg Ser Ala Leu Cys Ile Phe Lys Ile Ala
  65                  70                  75                  80
 Arg Lys Leu Leu Phe Leu Phe Arg Ile Lys Glu Asp Asn Glu Arg Phe
                  85                  90                  95    
 Glu Lys Leu Cys Arg Ser Ile Leu Ser Ser Met Asp Ala Glu Asn Glu
             100                 105                 110        
 Pro Lys Val Trp Tyr Val Ser Leu Ala Cys Ser Lys Asp Leu Thr Leu
         115                 120                 125            
 Leu Trp Ile Gln Gln Ile Lys Asn Ile Leu Trp Tyr Cys Cys Asp Phe
     130                 135                 140                
 Leu Lys Gln Leu Lys Pro Glu Ile Leu Gln Asp Ser Arg Leu Ile Thr
 145                 150                 155                 160
 Leu Tyr Leu Thr Met Leu Val Thr Phe Thr Asp Thr Ser Thr Trp Lys
                 165                 170                 175    
 Ile Leu Arg Gly Lys Gly Glu Ser Leu Arg Pro Ala Met Asn His Ile
             180                 185                 190        
 Cys Ala Asn Ile Met Gly His Leu Asn Gln His Gly Phe Tyr Ser Val
         195                 200                 205            
 Leu Gln Ile Leu Leu Thr Arg Gly Leu Ala Arg Pro Arg Pro Cys Leu
     210                 215                 220                
 Ser Lys Gly Thr Leu Thr Ala Ala Phe Ser Leu Ala Leu Arg Pro Val
 225                 230                 235                 240
 Ile Ala Ala Gln Phe Ser Asp Asn Leu Ile Arg Pro Phe Leu Ile His
                 245                 250                 255    
 Ile Met Ser Val Pro Ala Leu Val Thr His Leu Ser Thr Val Thr Pro
             260                 265                 270        
 Glu Arg Leu Thr Val Leu Glu Ser His Asp Met Leu Arg Lys Phe Ile
         275                 280                 285            
 Ile Phe Leu Arg Asp Gln Asp Arg Cys Arg Asp Val Cys Glu Ser Leu
     290                 295                 300                
 Glu Gly Cys His Thr Leu Cys Leu Met Gly Asn Leu Leu His Leu Gly
 305                 310                 315                 320
 Ser Leu Ser Pro Arg Val Leu Glu Glu Glu Thr Asp Gly Phe Val Ser
                 325                 330                 335    
 Leu Leu Thr Gln Thr Leu Cys Tyr Cys Arg Lys Tyr Val Ser Gln Lys
             340                 345                 350        
 Lys Ser Asn Leu Thr His Trp His Pro Val Leu Gly Trp Phe Ser Gln
         355                 360                 365            
 Ser Val Asp Tyr Gly Leu Asn Glu Ser Met His Leu Ile Thr Lys Gln
     370                 375                 380                
 Leu Gln Phe Leu Trp Gly Val Pro Leu Ile Arg Ile Phe Phe Cys Asp
 385                 390                 395                 400
 Ile Leu Ser Lys Lys Leu Leu Glu Ser Gln Glu Pro Ala His Ala Gln
                 405                 410                 415    
 Pro Ala Ser Pro Gln Asn Val Leu Pro Val Lys Ser Leu Leu Lys Arg
             420                 425                 430        
 Ala Phe Gln Lys Ser Ala Ser Val Arg Asn Ile Leu Arg Pro Val Gly
         435                 440                 445            
 Gly Lys Arg Val Asp Ser Ala Glu Val Gln Lys Val Cys Asn Ile Cys
     450                 455                 460                
 Val Leu Tyr Gln Thr Ser Leu Thr Thr Leu Thr Gln Ile Arg Leu Gln
 465                 470                 475                 480
 Ile Leu Thr Gly Leu Thr Tyr Leu Asp Asp Leu Leu Pro Lys Leu Trp
                 485                 490                 495    
 Ala Phe Ile Cys Glu Leu Gly Pro His Gly Gly Leu Lys Leu Phe Leu
             500                 505                 510        
 Glu Cys Leu Asn Asn Asp Thr Glu Glu Ser Lys Gln Leu Leu Ala Met
         515                 520                 525            
 Leu Met Leu Phe Cys Asp Cys Ser Arg His Leu Ile Thr Ile Leu Asp
     530                 535                 540                
 Asp Ile Glu Val Tyr Glu Glu Gln Ile Ser Phe Lys Leu Glu Glu Leu
 545                 550                 555                 560
 Val Thr Ile Ser Ser Phe Leu Asn Ser Phe Val Phe Lys Met Ile Trp
                 565                 570                 575    
 Asp Gly Ile Val Glu Asn Ala Lys Gly Glu Thr Leu Glu Leu Phe Gln
             580                 585                 590        
 Ser Val His Gly Trp Leu Met Val Leu Tyr Glu Arg Asp Cys Arg Arg
         595                 600                 605            
 Arg Phe Thr Pro Glu Asp His Trp Leu Arg Lys Asp Leu Lys Pro Ser
     610                 615                 620                
 Val Leu Phe Gln Glu Leu Asp Arg Asp Arg Lys Arg Ala Gln Leu Ile
 625                 630                 635                 640
 Leu Gln Tyr Ile Pro His Val Ile Pro His Lys Asn Arg Val Leu Leu
                 645                 650                 655    
 Phe Arg Thr Met Val Thr Lys Glu Lys Glu Lys Leu Gly Leu Val Glu
             660                 665                 670        
 Thr Ser Ser Ala Ser Pro His Val Thr His Ile Thr Ile Arg Arg Ser
         675                 680                 685            
 Arg Met Leu Glu Asp Gly Tyr Glu Gln Leu Arg Gln Leu Ser Gln His
     690                 695                 700                
 Ala Met Lys Gly Val Ile Arg Val Lys Phe Val Asn Asp Leu Gly Val
 705                 710                 715                 720
 Asp Glu Ala Gly Ile Asp Gln Asp Gly Val Phe Lys Glu Phe Leu Glu
                 725                 730                 735    
 Glu Ile Ile Lys Arg Val Phe Asp Pro Ala Leu Asn Leu Phe Lys Thr
             740                 745                 750        
 Thr Ser Gly Asp Glu Arg Leu Tyr Pro Ser Pro Thr Ser Tyr Ile His
         755                 760                 765            
 Glu Asn Tyr Leu Gln Leu Phe Glu Phe Val Gly Lys Met Leu Gly Lys
     770                 775                 780                
 Ala Val Tyr Glu Gly Ile Val Val Asp Val Pro Phe Ala Ser Phe Phe
 785                 790                 795                 800
 Leu Ser Gln Leu Leu Gly His His His Ser Val Phe Tyr Ser Ser Val
                 805                 810                 815    
 Asp Glu Leu Pro Ser Leu Asp Ser Glu Phe Tyr Lys Asn Leu Thr Ser
             820                 825                 830        
 Ile Lys Arg Tyr Asp Gly Asp Ile Thr Asp Leu Gly Leu Thr Leu Ser
         835                 840                 845            
 Tyr Asp Glu Asp Val Met Gly Gln Leu Val Cys His Glu Leu Ile Pro
     850                 855                 860                
 Gly Gly Lys Thr Ile Pro Val Thr Asn Glu Asn Lys Ile Ser Tyr Ile
 865                 870                 875                 880
 His Leu Met Ala His Phe Arg Met His Thr Gln Ile Lys Asn Gln Thr
                 885                 890                 895    
 Ala Ala Leu Ile Ser Gly Phe Arg Ser Ile Ile Lys Pro Glu Trp Ile
             900                 905                 910        
 Arg Met Phe Ser Thr Pro Glu Leu Gln Arg Leu Ile Ser Gly Asp Asn
         915                 920                 925            
 Ala Glu Ile Asp Leu Glu Asp Leu Lys Lys His Thr Val Tyr Tyr Gly
     930                 935                 940                
 Gly Phe His Gly Ser His Arg Val Ile Ile Trp Leu Trp Asp Ile Leu
 945                 950                 955                 960
 Ala Ser Asp Phe Thr Pro Asp Glu Arg Ala Met Phe Leu Lys Phe Val
                 965                 970                 975    
 Thr Ser Cys Ser Arg Pro Pro Leu Leu Gly Phe Ala Tyr Leu Lys Pro
             980                 985                 990        
 Pro Phe Ser Ile Arg Cys Val Glu Val Ser Asp Asp Gln Asp Thr Gly
         995                1000                1005            
 Asp Thr Leu Gly Ser Val Leu Arg Gly Phe Phe Thr Ile Arg Lys Arg
    1010                1015                1020                
 Glu Pro Gly Gly Arg Leu Pro Thr Ser Ser Thr Cys Phe Asn Leu Leu
1025                1030                1035                1040
 Lys Leu Pro Asn Tyr Ser Lys Lys Ser Val Leu Arg Glu Lys Leu Arg
                1045                1050                1055    
 Tyr Ala Ile Ser Met Asn Thr Gly Phe Glu Leu Ser
            1060                1065            



      <210> 620
      <211> 139
      <212> PRT
      <213> Homo sapiens


      <400> 620
 Met Ser Leu Leu Gln Cys Gly Gly Ile Arg Cys Phe Lys Met Pro Glu
   1               5                  10                  15    
 Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys Lys Ala Val
              20                  25                  30        
 Thr Lys Ala Gln Lys Lys Asp Gly Lys Lys Arg Lys Arg Ser Arg Lys
          35                  40                  45            
 Glu Ser Tyr Ser Val Tyr Val Tyr Lys Val Leu Lys Gln Val His Pro
      50                  55                  60                
 Asp Thr Gly Ile Ser Ser Lys Ala Met Gly Ile Met Asn Ser Phe Val
  65                  70                  75                  80
 Asn Asp Ile Phe Glu Arg Ile Ala Gly Glu Ala Ser Arg Leu Ala His
                  85                  90                  95    
 Tyr Asn Lys Arg Ser Thr Ile Thr Ser Arg Glu Ile Gln Thr Ala Val
             100                 105                 110        
 Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala Val Ser Glu Gly
         115                 120                 125            
 Thr Lys Ala Val Thr Lys Tyr Thr Ser Ser Lys
     130                 135                



      <210> 621
      <211> 66
      <212> PRT
      <213> Homo sapiens


      <400> 621
 Met Asp Pro Pro Ala Arg Lys Glu Lys Thr Lys Val Lys Glu Ser Val
   1               5                  10                  15    
 Ser Arg Val Glu Lys Ala Lys Gln Lys Ser Ala Gln Gln Glu Leu Lys
              20                  25                  30        
 Gln Arg Gln Arg Ala Glu Ile Tyr Ala Leu Asn Arg Val Met Thr Glu
          35                  40                  45            
 Leu Glu Gln Gln Gln Phe Asp Glu Phe Cys Lys Gln Met Gln Pro Pro
      50                  55                  60                
 Gly Glu
  65    



      <210> 622
      <211> 1255
      <212> PRT
      <213> Homo sapiens


      <400> 622
 Met Lys Asn Ser Pro Ser Glu Ala Gln Asn Leu Asp Glu Asn Thr Thr
   1               5                  10                  15    
 Glu Gly Trp Glu Asn Arg Ile Arg Leu Trp Thr Asp Gln Tyr Glu Glu
              20                  25                  30        
 Ala Phe Thr Asn Gln Tyr Ser Ala Asp Val Gln Asn Ala Leu Glu Gln
          35                  40                  45            
 His Leu His Ser Ser Lys Glu Phe Val Gly Lys Pro Thr Ile Leu Asp
      50                  55                  60                
 Thr Ile Asn Lys Thr Glu Leu Ala Cys Asn Asn Thr Val Ile Gly Ser
  65                  70                  75                  80
 Gln Met Gln Leu Gln Leu Gly Arg Val Thr Arg Val Gln Lys His Arg
                  85                  90                  95    
 Lys Ile Leu Arg Ala Ala Arg Asp Leu Ala Leu Asp Thr Leu Ile Ile
             100                 105                 110        
 Glu Tyr Arg Gly Lys Val Met Leu Arg Gln Gln Phe Glu Val Asn Gly
         115                 120                 125            
 His Phe Phe Lys Lys Pro Tyr Pro Phe Val Leu Phe Tyr Ser Lys Phe
     130                 135                 140                
 Asn Gly Val Glu Met Cys Val Asp Ala Arg Thr Phe Gly Asn Asp Ala
 145                 150                 155                 160
 Arg Phe Ile Arg Arg Ser Cys Thr Pro Asn Ala Glu Val Arg His Met
                 165                 170                 175    
 Ile Ala Asp Gly Met Ile His Leu Cys Ile Tyr Ala Val Ser Ala Ile
             180                 185                 190        
 Thr Lys Asp Ala Glu Val Thr Ile Ala Phe Asp Tyr Glu Tyr Ser Asn
         195                 200                 205            
 Cys Asn Tyr Lys Val Asp Cys Ala Cys His Lys Gly Asn Arg Asn Cys
     210                 215                 220                
 Pro Ile Gln Lys Arg Asn Pro Asn Ala Thr Glu Leu Pro Leu Leu Pro
 225                 230                 235                 240
 Pro Pro Pro Ser Leu Pro Thr Ile Gly Ala Glu Thr Arg Arg Arg Lys
                 245                 250                 255    
 Ala Arg Arg Lys Glu Leu Glu Met Glu Gln Gln Asn Glu Ala Ser Glu
             260                 265                 270        
 Glu Asn Asn Asp Gln Gln Ser Gln Glu Val Pro Glu Lys Val Thr Val
         275                 280                 285            
 Ser Ser Asp His Glu Glu Val Asp Asn Pro Glu Glu Lys Pro Glu Glu
     290                 295                 300                
 Glu Lys Glu Glu Val Ile Asp Asp Gln Glu Asn Leu Ala His Ser Arg
 305                 310                 315                 320
 Arg Thr Arg Glu Asp Arg Lys Val Glu Ala Ile Met His Ala Phe Glu
                 325                 330                 335    
 Asn Leu Glu Lys Arg Lys Lys Arg Arg Asp Gln Pro Leu Glu Gln Ser
             340                 345                 350        
 Asn Ser Asp Val Glu Ile Thr Thr Thr Thr Ser Glu Thr Pro Val Gly
         355                 360                 365            
 Glu Glu Thr Lys Thr Glu Ala Pro Glu Ser Glu Val Ser Asn Ser Val
     370                 375                 380                
 Ser Asn Val Thr Ile Pro Ser Thr Pro Gln Ser Val Gly Val Asn Thr
 385                 390                 395                 400
 Arg Arg Ser Ser Gln Ala Gly Asp Ile Ala Ala Glu Lys Leu Val Pro
                 405                 410                 415    
 Lys Pro Pro Pro Ala Lys Pro Ser Arg Pro Arg Pro Lys Ser Arg Ile
             420                 425                 430        
 Ser Arg Tyr Arg Thr Ser Ser Ala Gln Arg Leu Lys Arg Gln Lys Gln
         435                 440                 445            
 Ala Asn Ala Gln Gln Ala Glu Leu Ser Gln Ala Ala Leu Glu Glu Gly
     450                 455                 460                
 Gly Ser Asn Ser Leu Val Thr Pro Thr Glu Ala Gly Ser Leu Asp Ser
 465                 470                 475                 480
 Ser Gly Glu Asn Arg Pro Leu Thr Gly Ser Asp Pro Thr Val Val Ser
                 485                 490                 495    
 Ile Thr Gly Ser His Val Asn Arg Ala Ala Ser Lys Tyr Pro Lys Thr
             500                 505                 510        
 Lys Lys Tyr Leu Val Thr Glu Trp Leu Asn Asp Lys Ala Glu Lys Gln
         515                 520                 525            
 Glu Cys Pro Val Glu Cys Pro Leu Arg Ile Thr Thr Asp Pro Thr Val
     530                 535                 540                
 Leu Ala Thr Thr Leu Asn Met Leu Pro Gly Leu Ile His Ser Pro Leu
 545                 550                 555                 560
 Ile Cys Thr Thr Pro Lys His Tyr Ile Arg Phe Gly Ser Pro Phe Ile
                 565                 570                 575    
 Pro Glu Arg Arg Arg Arg Pro Leu Leu Pro Asp Gly Thr Phe Ser Pro
             580                 585                 590        
 Cys Lys Lys Arg Trp Ile Lys Gln Ala Leu Glu Glu Gly Met Thr Gln
         595                 600                 605            
 Thr Ser Ser Val Pro Gln Glu Thr Arg Thr Gln His Leu Tyr Gln Ser
     610                 615                 620                
 Asn Glu Asn Ser Ser Ser Ser Ser Ile Cys Lys Asp Asn Ala Asp Leu
 625                 630                 635                 640
 Leu Ser Pro Leu Lys Lys Trp Lys Ser Arg Tyr Leu Met Glu Gln Asn
                 645                 650                 655    
 Val Thr Lys Leu Leu Arg Pro Leu Ser Pro Val Thr Pro Pro Pro Pro
             660                 665                 670        
 Asn Ser Gly Ser Lys Ser Pro Gln Leu Ala Thr Pro Gly Ser Ser His
         675                 680                 685            
 Pro Gly Glu Glu Glu Cys Arg Asn Gly Tyr Ser Leu Met Phe Ser Pro
     690                 695                 700                
 Val Thr Ser Leu Thr Thr Ala Ser Arg Cys Asn Thr Pro Leu Gln Phe
 705                 710                 715                 720
 Glu Leu Cys His Arg Lys Asp Leu Asp Leu Ala Lys Val Gly Tyr Leu
                 725                 730                 735    
 Asp Ser Asn Thr Asn Ser Cys Ala Asp Arg Pro Ser Leu Leu Asn Ser
             740                 745                 750        
 Gly His Ser Asp Leu Ala Pro His Pro Ser Leu Gly Pro Thr Ser Glu
         755                 760                 765            
 Thr Gly Phe Pro Ser Arg Ser Gly Asp Gly His Gln Thr Leu Val Arg
     770                 775                 780                
 Asn Ser Asp Gln Ala Phe Arg Thr Glu Phe Asn Leu Met Tyr Ala Tyr
 785                 790                 795                 800
 Ser Pro Leu Asn Ala Met Pro Arg Ala Asp Gly Leu Tyr Arg Gly Ser
                 805                 810                 815    
 Pro Leu Val Gly Asp Arg Lys Pro Leu His Leu Asp Gly Gly Tyr Cys
             820                 825                 830        
 Ser Pro Ala Glu Gly Phe Ser Ser Arg Tyr Glu His Gly Leu Met Lys
         835                 840                 845            
 Asp Leu Ser Arg Gly Ser Leu Ser Pro Gly Gly Glu Arg Ala Cys Glu
     850                 855                 860                
 Gly Val Pro Ser Ala Pro Gln Asn Pro Pro Gln Arg Lys Lys Val Ser
 865                 870                 875                 880
 Leu Leu Glu Tyr Arg Lys Arg Lys Gln Glu Ala Lys Glu Asn Ser Ala
                 885                 890                 895    
 Gly Gly Gly Gly Asp Ser Ala Gln Ser Lys Ser Lys Ser Ala Gly Ala
             900                 905                 910        
 Gly Gln Gly Ser Ser Asn Ser Val Ser Asp Thr Gly Ala His Gly Val
         915                 920                 925            
 Gln Gly Ser Ser Ala Arg Thr Pro Ser Ser Pro His Lys Lys Phe Ser
     930                 935                 940                
 Pro Ser His Ser Ser Met Ser His Leu Glu Ala Val Ser Pro Ser Asp
 945                 950                 955                 960
 Ser Arg Gly Thr Ser Ser Ser His Cys Arg Pro Gln Glu Asn Ile Ser
                 965                 970                 975    
 Ser Arg Trp Met Val Pro Thr Ser Val Glu Arg Leu Arg Glu Gly Gly
             980                 985                 990        
 Ser Ile Pro Lys Val Leu Arg Ser Ser Val Arg Val Ala Gln Lys Gly
         995                1000                1005            
 Glu Pro Ser Pro Thr Trp Glu Ser Asn Ile Thr Glu Lys Asp Ser Asp
    1010                1015                1020                
 Pro Ala Asp Gly Glu Gly Pro Glu Thr Leu Ser Ser Ala Leu Ser Lys
1025                1030                1035                1040
 Gly Ala Thr Val Tyr Ser Pro Ser Arg Tyr Ser Tyr Gln Leu Leu Gln
                1045                1050                1055    
 Cys Asp Ser Pro Arg Thr Glu Ser Gln Ser Leu Leu Gln Gln Ser Ser
            1060                1065                1070        
 Ser Pro Phe Arg Gly His Pro Thr Gln Ser Pro Gly Tyr Ser Tyr Arg
        1075                1080                1085            
 Thr Thr Ala Leu Arg Pro Gly Asn Pro Pro Ser His Gly Ser Ser Glu
    1090                1095                1100                
 Ser Ser Leu Ser Ser Thr Ser Tyr Ser Ser Pro Ala His Pro Val Ser
1105                1110                1115                1120
 Thr Asp Ser Leu Ala Pro Phe Thr Gly Thr Pro Gly Tyr Phe Ser Ser
                1125                1130                1135    
 Gln Pro His Ser Gly Asn Ser Thr Gly Ser Asn Leu Pro Arg Arg Ser
            1140                1145                1150        
 Cys Pro Ser Ser Ala Ala Ser Pro Thr Leu Gln Gly Pro Ser Asp Ser
        1155                1160                1165            
 Pro Thr Ser Asp Ser Val Ser Gln Ser Ser Thr Gly Thr Leu Ser Ser
    1170                1175                1180                
 Thr Ser Phe Pro Gln Asn Ser Arg Ser Ser Leu Pro Ser Asp Leu Arg
1185                1190                1195                1200
 Thr Ile Ser Leu Pro Ser Ala Gly Gln Ser Ala Val Tyr Gln Ala Ser
                1205                1210                1215    
 Arg Val Ser Ala Val Ser Asn Ser Gln His Tyr Pro His Arg Gly Ser
            1220                1225                1230        
 Gly Gly Val His Gln Tyr Arg Leu Gln Pro Leu Gln Gly Ser Gly Val
        1235                1240                1245            
 Lys Thr Gln Thr Gly Leu Ser
    1250                1255



      <210> 623
      <211> 173
      <212> PRT
      <213> Homo sapiens


      <400> 623
 Met Lys Gln Glu Val Lys Lys Val Val Asn Pro Leu Leu Glu Lys Arg
   1               5                  10                  15    
 Pro Lys Asn Phe Gly Ile Gly Gln Asp Ile Gln Pro Lys Arg Asp Leu
              20                  25                  30        
 Thr Cys Phe Lys Lys Trp Ser His Tyr Ile Arg Leu Gln Trp Gln Arg
          35                  40                  45            
 Val Ile Leu Cys Lys Trp Leu Lys Val His Pro Glu Ile Asn Gln Phe
      50                  55                  60                
 Thr Gln Ala Leu His His Gln Thr Ala Thr Gln Leu Leu Gln Leu Ala
  65                  70                  75                  80
 His Asn Tyr Arg Pro Asn Lys Arg Lys Thr Lys Gln Glu Lys Lys Gln
                  85                  90                  95    
 Arg Leu Leu Val Arg Ala Glu Lys Lys Ala Cys Ser Lys Gly Asp Ile
             100                 105                 110        
 Ser Thr Arg Arg Pro Leu Val Leu Gln Ala Gly Val Asn Thr Val Thr
         115                 120                 125            
 Thr Leu Val Glu Asn Lys Lys Thr Gln Leu Val Val Met Ala His Asp
     130                 135                 140                
 Val Asp Thr Ile Gln Leu Val Asn Ser Glu Asp Lys Gly Ala Leu Ala
 145                 150                 155                 160
 Lys Leu Ala Glu Ala Met Arg Thr Asn Tyr Asn Asn Arg
                 165                 170            



      <210> 624
      <211> 224
      <212> PRT
      <213> Homo sapiens


      <400> 624
 Met Pro Pro Arg Lys Lys Arg Arg Gln Pro Ser Gln Lys Ala Pro Leu
   1               5                  10                  15    
 Leu Phe His Gln Gln Pro Leu Glu Gly Pro Lys His Ser Cys Ala Ser
              20                  25                  30        
 Thr Gln Leu Pro Ile Thr His Thr Arg Gln Val Ser Pro Asp Phe Asp
          35                  40                  45            
 Thr Ala Ala Gly Ser Leu Phe Pro Ala Tyr Gln Lys His Gln Asn Arg
      50                  55                  60                
 Ala Arg His Ser Ser Arg Lys Pro Thr Thr Ser Lys Phe Pro His Leu
  65                  70                  75                  80
 Thr Phe Glu Ser Pro Gln Ser Ser Ser Ser Glu Thr Leu Gly Ile Pro
                  85                  90                  95    
 Leu Ile Arg Glu Cys Pro Ser Glu Ser Glu Lys Asp Val Ser Arg Arg
             100                 105                 110        
 Pro Leu Val Pro Val Leu Ser Pro Gln Ser Cys Gly Asn Met Ser Val
         115                 120                 125            
 Gln Ala Leu Gln Ser Leu Pro Tyr Val Phe Ile Pro Pro Asp Ile Gln
     130                 135                 140                
 Thr Pro Glu Ser Ser Ser Val Lys Glu Glu Leu Ile Pro Gln Asp Gln
 145                 150                 155                 160
 Lys Glu Asn Ser Leu Leu Ser Cys Thr Leu His Thr Gly Thr Pro Asn
                 165                 170                 175    
 Ser Pro Glu Pro Gly Pro Val Leu Val Lys Asp Thr Pro Glu Asp Lys
             180                 185                 190        
 Tyr Gly Ile Lys Val Thr Trp Arg Arg Arg Gln His Leu Leu Ala Tyr
         195                 200                 205            
 Leu Arg Glu Arg Gly Lys Leu Ser Arg Ser Gln Phe Leu Val Lys Ser
     210                 215                 220                





      <210> 625
      <211> 226
      <212> PRT
      <213> Homo sapiens


      <400> 625
 Met Glu Gly Ser Ala Val Thr Val Leu Glu Arg Gly Gly Ala Ser Ser
   1               5                  10                  15    
 Pro Ala Glu Arg Arg Ser Lys Arg Arg Gln Glu Arg Arg Arg Arg Arg
              20                  25                  30        
 Arg Arg Arg Arg Arg Pro Ser Thr Arg Gly Gly Pro Ser Pro Gly Ser
          35                  40                  45            
 Arg Pro Ala Pro Arg His Lys Gly Ser Ala Pro Ala Ala Arg His Pro
      50                  55                  60                
 Ala Ser Leu Pro Asn Val Leu Gly His Arg Lys Glu Glu Pro Gly Pro
  65                  70                  75                  80
 Phe Arg Glu Pro Val Asp Glu Val Leu Gln Ile Pro Pro Ser Leu Leu
                  85                  90                  95    
 Thr Cys Gly Gly Cys Gln Gln Asn Ile Gly Asp Arg Tyr Phe Leu Lys
             100                 105                 110        
 Ala Ile Asp Gln Tyr Trp His Glu Asp Cys Leu Ser Cys Asp Leu Cys
         115                 120                 125            
 Gly Cys Arg Leu Gly Glu Val Gly Arg Arg Leu Tyr Tyr Lys Leu Gly
     130                 135                 140                
 Arg Lys Leu Cys Arg Arg Asp Tyr Leu Arg Leu Phe Gly Gln Asp Gly
 145                 150                 155                 160
 Leu Cys Ala Ser Cys Asp Lys Arg Ile Arg Ala Tyr Glu Met Thr Met
                 165                 170                 175    
 Arg Val Lys Asp Lys Val Tyr His Leu Glu Cys Phe Lys Cys Ala Ala
             180                 185                 190        
 Cys Gln Lys His Phe Cys Val Gly Asp Arg Tyr Leu Leu Ile Asn Ser
         195                 200                 205            
 Asp Ile Val Cys Glu Gln Asp Ile Tyr Glu Trp Thr Lys Ile Asn Gly
     210                 215                 220                
 Met Ile
 225    



      <210> 626
      <211> 516
      <212> PRT
      <213> Homo sapiens


      <400> 626
 Met Ile Lys Ile Asn Phe Thr Leu Lys Arg Asp Asp Val Thr Ser Arg
   1               5                  10                  15    
 Val Leu Val Glu His Arg Cys Gly Ser Glu Asn Val Ala Ala Thr Thr
              20                  25                  30        
 Gln Lys Thr Leu Arg Tyr Gly Val Leu Thr Val Phe Ser Glu Glu Asp
          35                  40                  45            
 Leu His Thr Met Ser Ser Ala Val Val Gln Leu Tyr Ala Ala Asp Arg
      50                  55                  60                
 Asn Cys Met Trp Ser Lys Lys Cys Ser Gly Val Ala Cys Leu Val Lys
  65                  70                  75                  80
 Asp Asn Pro Gln Arg Ser Tyr Phe Leu Arg Ile Phe Asp Ile Lys Asp
                  85                  90                  95    
 Gly Lys Leu Leu Trp Glu Gln Glu Leu Tyr Asn Asn Phe Val Tyr Asn
             100                 105                 110        
 Ser Pro Arg Gly Tyr Phe His Thr Phe Ala Gly Asp Thr Cys Gln Val
         115                 120                 125            
 Ala Leu Asn Phe Ala Asn Glu Glu Glu Ala Lys Lys Phe Arg Lys Ala
     130                 135                 140                
 Val Thr Asp Leu Leu Gly Arg Arg Gln Arg Lys Ser Glu Lys Arg Arg
 145                 150                 155                 160
 Asp Pro Pro Asn Gly Pro Asn Leu Pro Met Ala Thr Val Asp Ile Lys
                 165                 170                 175    
 Asn Pro Glu Ile Thr Thr Asn Arg Phe Tyr Gly Pro Gln Val Asn Asn
             180                 185                 190        
 Ile Ser His Thr Lys Glu Lys Lys Lys Gly Lys Ala Lys Lys Lys Arg
         195                 200                 205            
 Leu Thr Lys Gly Asp Ile Gly Thr Pro Ser Asn Phe Gln His Ile Gly
     210                 215                 220                
 His Val Gly Trp Asp Pro Asn Thr Gly Ser Asp Leu Asn Asn Leu Asp
 225                 230                 235                 240
 Pro Glu Leu Lys Asn Leu Phe Asp Met Cys Gly Ile Leu Glu Ala Gln
                 245                 250                 255    
 Leu Lys Glu Arg Glu Thr Leu Lys Val Ile Tyr Asp Phe Ile Glu Lys
             260                 265                 270        
 Thr Gly Gly Val Glu Ala Val Lys Asn Glu Leu Arg Arg Gln Ala Pro
         275                 280                 285            
 Pro Pro Pro Pro Pro Ser Arg Gly Gly Pro Pro Pro Pro Pro Pro Pro
     290                 295                 300                
 Pro His Ser Ser Gly Pro Pro Pro Pro Pro Ala Arg Gly Arg Gly Ala
 305                 310                 315                 320
 Pro Pro Pro Pro Pro Ser Arg Ala Pro Thr Ala Ala Pro Pro Pro Pro
                 325                 330                 335    
 Pro Pro Ser Arg Pro Ser Val Glu Val Pro Pro Pro Pro Pro Asn Arg
             340                 345                 350        
 Met Tyr Pro Pro Pro Pro Pro Ala Leu Pro Ser Ser Ala Pro Ser Gly
         355                 360                 365            
 Pro Pro Pro Pro Pro Pro Ser Val Leu Gly Val Gly Pro Val Ala Pro
     370                 375                 380                
 Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Pro Pro Pro Pro
 385                 390                 395                 400
 Gly Leu Pro Ser Asp Gly Asp His Gln Val Pro Thr Thr Ala Gly Asn
                 405                 410                 415    
 Lys Ala Ala Leu Leu Asp Gln Ile Arg Glu Gly Ala Gln Leu Lys Lys
             420                 425                 430        
 Val Glu Gln Asn Ser Arg Pro Val Ser Cys Ser Gly Arg Asp Ala Leu
         435                 440                 445            
 Leu Asp Gln Ile Arg Gln Gly Ile Gln Leu Lys Ser Val Ala Asp Gly
     450                 455                 460                
 Gln Glu Ser Thr Pro Pro Thr Pro Ala Pro Thr Ser Gly Ile Val Gly
 465                 470                 475                 480
 Ala Leu Met Glu Val Met Gln Lys Arg Ser Lys Ala Ile His Ser Ser
                 485                 490                 495    
 Asp Glu Asp Glu Asp Glu Asp Asp Glu Glu Asp Phe Glu Asp Asp Asp
             500                 505                 510        
 Glu Trp Glu Asp
         515    



      <210> 627
      <211> 1415
      <212> PRT
      <213> Homo sapiens


      <400> 627
 Met Pro Phe Ala Ala Lys Asn Met Phe Tyr Asp Glu Arg Trp Lys Glu
   1               5                  10                  15    
 Lys Gln Glu Gln Gly Phe Thr Trp Trp Leu Asn Phe Ile Leu Thr Pro
              20                  25                  30        
 Asp Asp Phe Thr Val Lys Thr Asn Ile Ser Glu Val Asn Ala Ala Thr
          35                  40                  45            
 Leu Leu Leu Gly Ile Glu Asn Gln His Lys Ile Ser Val Pro Arg Ala
      50                  55                  60                
 Pro Thr Lys Glu Glu Met Ser Leu Arg Ala Tyr Thr Ala Arg Cys Arg
  65                  70                  75                  80
 Leu Asn Arg Leu Arg Arg Ala Ala Cys Arg Leu Phe Thr Ser Glu Lys
                  85                  90                  95    
 Met Val Lys Ala Ile Lys Lys Leu Glu Ile Glu Ile Glu Ala Arg Arg
             100                 105                 110        
 Leu Ile Val Arg Lys Asp Arg His Leu Trp Lys Asp Val Gly Glu Arg
         115                 120                 125            
 Gln Lys Val Leu Asn Trp Leu Leu Ser Tyr Asn Pro Leu Trp Leu Arg
     130                 135                 140                
 Ile Gly Leu Glu Thr Thr Tyr Gly Glu Leu Ile Ser Leu Glu Asp Asn
 145                 150                 155                 160
 Ser Asp Val Thr Gly Leu Ala Met Phe Ile Leu Asn Arg Leu Leu Trp
                 165                 170                 175    
 Asn Pro Asp Ile Ala Ala Glu Tyr Arg His Pro Thr Val Pro His Leu
             180                 185                 190        
 Tyr Arg Asp Gly His Glu Glu Ala Leu Ser Lys Phe Thr Leu Lys Lys
         195                 200                 205            
 Leu Leu Leu Leu Val Cys Phe Leu Asp Tyr Ala Lys Ile Ser Arg Leu
     210                 215                 220                
 Ile Asp His Asp Pro Cys Leu Phe Cys Lys Asp Ala Glu Phe Lys Ala
 225                 230                 235                 240
 Ser Lys Glu Ile Leu Leu Ala Phe Ser Arg Asp Phe Leu Ser Gly Glu
                 245                 250                 255    
 Gly Asp Leu Ser Arg His Leu Gly Leu Leu Gly Leu Pro Val Asn His
             260                 265                 270        
 Val Gln Thr Pro Phe Asp Glu Phe Asp Phe Ala Val Thr Asn Leu Ala
         275                 280                 285            
 Val Asp Leu Gln Cys Gly Val Arg Leu Val Arg Thr Met Glu Leu Leu
     290                 295                 300                
 Thr Gln Asn Trp Asp Leu Ser Lys Lys Leu Arg Ile Pro Ala Ile Ser
 305                 310                 315                 320
 Arg Leu Gln Lys Met His Asn Val Asp Ile Val Leu Gln Val Leu Lys
                 325                 330                 335    
 Ser Arg Gly Ile Glu Leu Ser Asp Glu His Gly Asn Thr Ile Leu Ser
             340                 345                 350        
 Lys Asp Ile Val Asp Arg His Arg Glu Lys Thr Leu Arg Leu Leu Trp
         355                 360                 365            
 Lys Ile Ala Phe Ala Phe Gln Val Asp Ile Ser Leu Asn Leu Asp Gln
     370                 375                 380                
 Leu Lys Glu Glu Ile Ala Phe Leu Lys His Thr Lys Ser Ile Lys Lys
 385                 390                 395                 400
 Thr Ile Ser Leu Leu Ser Cys His Ser Asp Asp Leu Ile Asn Lys Lys
                 405                 410                 415    
 Lys Gly Lys Arg Asp Ser Gly Ser Phe Glu Gln Tyr Ser Glu Asn Ile
             420                 425                 430        
 Lys Leu Leu Met Asp Trp Val Asn Ala Val Cys Ala Phe Tyr Asn Lys
         435                 440                 445            
 Lys Val Glu Asn Phe Thr Val Ser Phe Ser Asp Gly Arg Val Leu Cys
     450                 455                 460                
 Tyr Leu Ile His His Tyr His Pro Cys Tyr Val Pro Leu Asp Ala Ile
 465                 470                 475                 480
 Cys Gln Arg Thr Thr Gln Thr Val Glu Cys Thr Gln Thr Gly Ser Val
                 485                 490                 495    
 Val Leu Asn Ser Ser Ser Glu Ser Asp Asp Ser Ser Leu Asp Met Ser
             500                 505                 510        
 Leu Lys Ala Phe Asp His Glu Asn Thr Ser Glu Leu Tyr Lys Glu Leu
         515                 520                 525            
 Leu Glu Asn Glu Lys Lys Asn Phe His Leu Val Arg Ser Ala Val Arg
     530                 535                 540                
 Asp Leu Gly Gly Ile Pro Ala Met Ile Asn His Ser Asp Met Ser Asn
 545                 550                 555                 560
 Thr Ile Pro Asp Glu Lys Val Val Ile Thr Tyr Leu Ser Phe Leu Cys
                 565                 570                 575    
 Ala Arg Leu Leu Asp Leu Arg Lys Glu Ile Arg Ala Ala Arg Leu Ile
             580                 585                 590        
 Gln Thr Thr Trp Arg Lys Tyr Lys Leu Lys Thr Asp Leu Lys Arg His
         595                 600                 605            
 Gln Glu Arg Glu Lys Ala Ala Arg Ile Ile Gln Leu Ala Val Ile Asn
     610                 615                 620                
 Phe Leu Ala Lys Gln Arg Leu Arg Lys Arg Val Asn Ala Ala Leu Val
 625                 630                 635                 640
 Ile Gln Lys Tyr Trp Arg Arg Val Leu Ala Gln Arg Lys Leu Leu Met
                 645                 650                 655    
 Leu Lys Lys Glu Lys Leu Glu Lys Val Gln Asn Lys Ala Ala Ser Leu
             660                 665                 670        
 Ile Gln Gly Tyr Trp Arg Arg Tyr Ser Thr Arg Gln Arg Phe Leu Lys
         675                 680                 685            
 Leu Lys Tyr Tyr Ser Ile Ile Leu Gln Ser Arg Ile Arg Met Ile Ile
     690                 695                 700                
 Ala Val Thr Ser Tyr Lys Arg Tyr Leu Trp Ala Thr Val Thr Ile Gln
 705                 710                 715                 720
 Arg His Trp Arg Ala Tyr Leu Arg Arg Lys Gln Asp Gln Gln Arg Tyr
                 725                 730                 735    
 Glu Met Leu Lys Ser Ser Thr Leu Ile Ile Gln Ser Met Phe Arg Lys
             740                 745                 750        
 Trp Lys Gln Arg Lys Met Gln Ser Gln Val Lys Ala Thr Val Ile Leu
         755                 760                 765            
 Gln Arg Ala Phe Arg Glu Trp His Leu Arg Lys Gln Ala Lys Glu Glu
     770                 775                 780                
 Asn Ser Ala Ile Ile Ile Gln Ser Trp Tyr Arg Met His Lys Glu Leu
 785                 790                 795                 800
 Arg Lys Tyr Ile Tyr Ile Arg Ser Cys Val Val Ile Ile Gln Lys Arg
                 805                 810                 815    
 Phe Arg Cys Phe Gln Ala Gln Lys Leu Tyr Lys Lys Lys Lys Glu Ser
             820                 825                 830        
 Ile Leu Thr Ile Gln Lys Tyr Tyr Lys Ala Tyr Leu Lys Gly Lys Ile
         835                 840                 845            
 Glu Arg Thr Asn Tyr Leu Gln Lys Arg Ala Ala Ala Ile Gln Leu Gln
     850                 855                 860                
 Ala Ala Phe Arg Arg Leu Lys Ala His Asn Leu Cys Arg Gln Ile Arg
 865                 870                 875                 880
 Ala Ala Cys Val Ile Gln Ser Tyr Trp Arg Met Arg Gln Asp Arg Val
                 885                 890                 895    
 Arg Phe Leu Asn Leu Lys Lys Thr Ile Ile Lys Phe Gln Ala His Val
             900                 905                 910        
 Arg Lys His Gln Gln Arg Gln Lys Tyr Lys Lys Met Lys Lys Ala Ala
         915                 920                 925            
 Val Ile Ile Gln Thr His Phe Arg Ala Tyr Ile Phe Ala Met Lys Val
     930                 935                 940                
 Leu Ala Ser Tyr Gln Lys Thr Arg Ser Ala Val Ile Val Leu Gln Ser
 945                 950                 955                 960
 Ala Tyr Arg Gly Met Gln Ala Arg Lys Met Tyr Ile His Ile Leu Thr
                 965                 970                 975    
 Ser Val Ile Lys Ile Gln Ser Tyr Tyr Arg Ala Tyr Val Ser Lys Lys
             980                 985                 990        
 Glu Phe Leu Ser Leu Lys Asn Ala Thr Ile Lys Leu Gln Ser Thr Val
         995                1000                1005            
 Lys Met Lys Gln Thr Arg Lys Gln Tyr Leu His Leu Arg Ala Ala Ala
    1010                1015                1020                
 Leu Phe Ile Gln Gln Cys Tyr Arg Ser Lys Lys Ile Ala Ala Gln Lys
1025                1030                1035                1040
 Arg Glu Glu Tyr Met Gln Met Arg Glu Ser Cys Ile Lys Leu Gln Ala
                1045                1050                1055    
 Phe Val Arg Gly Tyr Leu Val Arg Lys Gln Met Arg Leu Gln Arg Lys
            1060                1065                1070        
 Ala Val Ile Ser Leu Gln Ser Tyr Phe Arg Met Arg Lys Ala Arg Gln
        1075                1080                1085            
 Tyr Tyr Leu Lys Met Tyr Lys Ala Ile Ile Val Ile Gln Asn Tyr Tyr
    1090                1095                1100                
 His Ala Tyr Lys Ala Gln Val Asn Gln Arg Lys Asn Phe Leu Gln Val
1105                1110                1115                1120
 Lys Lys Ala Ala Thr Cys Leu Gln Ala Ala Tyr Arg Gly Tyr Lys Ile
                1125                1130                1135    
 Gln Arg Trp Tyr Arg Ala Tyr Lys Thr Leu His Asp Thr Arg Thr His
            1140                1145                1150        
 Phe Leu Lys Thr Lys Ala Ala Val Ile Ser Leu Gln Ser Ala Tyr Arg
        1155                1160                1165            
 Gly Trp Lys Val Arg Lys Gln Ile Arg Arg Glu His Gln Ala Ala Leu
    1170                1175                1180                
 Lys Ile Gln Ser Ala Phe Arg Met Ala Lys Ala Gln Lys Gln Phe Arg
1185                1190                1195                1200
 Leu Phe Lys Thr Ala Ala Leu Val Ile Gln Gln Asn Phe Arg Ala Trp
                1205                1210                1215    
 Thr Ala Gly Arg Lys Gln Cys Met Glu Tyr Ile Glu Leu Arg His Ala
            1220                1225                1230        
 Val Leu Val Leu Gln Ser Met Trp Lys Gly Lys Thr Leu Arg Arg Gln
        1235                1240                1245            
 Leu Gln Arg Gln His Lys Cys Ala Ile Ile Ile Gln Ser Tyr Tyr Arg
    1250                1255                1260                
 Met His Val Gln Gln Lys Lys Trp Lys Ile Met Lys Lys Ala Ala Leu
1265                1270                1275                1280
 Leu Ile Gln Lys Tyr Tyr Arg Ala Tyr Ser Ile Gly Arg Glu Gln Asn
                1285                1290                1295    
 His Leu Tyr Leu Lys Thr Lys Ala Ala Val Val Thr Leu Gln Ser Ala
            1300                1305                1310        
 Tyr Arg Gly Met Lys Val Arg Lys Arg Ile Lys Asp Cys Asn Lys Ala
        1315                1320                1325            
 Ala Val Thr Ile Gln Ser Lys Tyr Arg Ala Tyr Lys Thr Lys Lys Lys
    1330                1335                1340                
 Tyr Ala Thr Tyr Arg Ala Ser Ala Ile Ile Ile Gln Arg Trp Tyr Arg
1345                1350                1355                1360
 Gly Ile Lys Ile Thr Asn His Gln His Lys Glu Tyr Leu Asn Leu Lys
                1365                1370                1375    
 Lys Thr Ala Ile Lys Ile Gln Ser Val Tyr Arg Val Leu Glu Leu Glu
            1380                1385                1390        
 Asp Ile Phe Asn Thr Cys Thr Gly Gln Pro Leu Val Leu Lys Pro Cys
        1395                1400                1405            
 Leu Lys Cys Ile Ser Gln Glu
    1410                1415



      <210> 628
      <211> 174
      <212> PRT
      <213> Homo sapiens


      <400> 628
 Met Ala Thr Val Ala Glu Leu Lys Ala Val Leu Lys Asp Thr Leu Glu
   1               5                  10                  15    
 Lys Lys Gly Val Leu Gly His Leu Lys Ala Arg Ile Arg Ala Glu Val
              20                  25                  30        
 Phe Asn Ala Leu Asp Asp Asp Arg Glu Pro Arg Pro Ser Leu Ser His
          35                  40                  45            
 Glu Asn Leu Leu Ile Asn Glu Leu Ile Arg Glu Tyr Leu Glu Phe Asn
      50                  55                  60                
 Lys Tyr Lys Tyr Thr Ala Ser Val Leu Ile Ala Glu Ser Gly Gln Pro
  65                  70                  75                  80
 Val Val Pro Leu Asp Arg Gln Phe Leu Ile His Glu Leu Asn Ala Phe
                  85                  90                  95    
 Glu Glu Ser Lys Asp Asn Thr Ile Pro Leu Leu Tyr Gly Ile Leu Ala
             100                 105                 110        
 His Phe Leu Arg Gly Thr Lys Asp Gly Ile Gln Asn Ala Phe Leu Lys
         115                 120                 125            
 Gly Pro Ser Leu Gln Pro Ser Asp Pro Ser Leu Gly Arg Gln Pro Ser
     130                 135                 140                
 Arg Arg Lys Pro Met Asp Asp His Leu Arg Lys Glu Glu Gln Lys Ser
 145                 150                 155                 160
 Thr Asn Ile Glu Asp Leu His Val Ser Gln Ala Val Asn Arg
                 165                 170                



      <210> 629
      <211> 378
      <212> PRT
      <213> Homo sapiens


      <400> 629
 Met Ala Asp Ala Ala Ala Thr Ala Gly Ala Gly Gly Ser Gly Thr Arg
   1               5                  10                  15    
 Ser Gly Ser Lys Gln Ser Thr Asn Pro Ala Asp Asn Tyr His Leu Ala
              20                  25                  30        
 Arg Arg Arg Thr Leu Gln Val Val Val Ser Ser Leu Leu Thr Glu Ala
          35                  40                  45            
 Gly Phe Glu Ser Ala Glu Lys Ala Ser Val Glu Thr Leu Thr Glu Met
      50                  55                  60                
 Leu Gln Ser Tyr Ile Ser Glu Ile Gly Arg Ser Ala Lys Ser Tyr Cys
  65                  70                  75                  80
 Glu His Thr Ala Arg Thr Gln Pro Thr Leu Ser Asp Ile Val Val Thr
                  85                  90                  95    
 Leu Val Glu Met Gly Phe Asn Val Asp Thr Leu Pro Ala Tyr Ala Lys
             100                 105                 110        
 Arg Ser Gln Arg Met Val Ile Thr Ala Pro Pro Val Thr Asn Gln Pro
         115                 120                 125            
 Val Thr Pro Lys Ala Leu Thr Ala Gly Gln Asn Arg Pro His Pro Pro
     130                 135                 140                
 His Ile Pro Ser His Phe Pro Glu Phe Pro Asp Pro His Thr Tyr Ile
 145                 150                 155                 160
 Lys Thr Pro Thr Tyr Arg Glu Pro Val Ser Asp Tyr Gln Val Leu Arg
                 165                 170                 175    
 Glu Lys Ala Ala Ser Gln Arg Arg Asp Val Glu Arg Ala Leu Thr Arg
             180                 185                 190        
 Phe Met Ala Lys Thr Gly Glu Thr Gln Ser Leu Phe Lys Asp Asp Val
         195                 200                 205            
 Ser Thr Phe Pro Leu Ile Ala Ala Arg Pro Phe Thr Ile Pro Tyr Leu
     210                 215                 220                
 Thr Ala Leu Leu Pro Ser Glu Leu Glu Met Gln Gln Met Glu Glu Thr
 225                 230                 235                 240
 Asp Ser Ser Glu Gln Asp Glu Gln Thr Asp Thr Glu Asn Leu Ala Leu
                 245                 250                 255    
 His Ile Ser Met Ile Gly Ile Thr Asn Asp Val His Val Leu Val Pro
             260                 265                 270        
 Ala Gly Ser Ala Ser Leu Ser Gly Thr Leu Lys Ala Gln Glu Val Ser
         275                 280                 285            
 Ser Leu Cys Trp Asp Val Ile Val Gly Thr Met Leu Gln Val Pro Glu
     290                 295                 300                
 Met Asp Glu Ser Val Ser Ser Val His Val Glu Leu Ile Asp Ala Val
 305                 310                 315                 320
 Tyr Phe Ala Leu Phe Leu Ser Met Glu Asp Ser Gly Ala Glu Lys Glu
                 325                 330                 335    
 Asn Thr Ser Val Leu Gln Gln Asn Pro Ser Leu Ser Gly Ser Arg Asn
             340                 345                 350        
 Gly Glu Glu Asn Ile Ile Asp Asn Pro Tyr Leu Arg Pro Val Lys Lys
         355                 360                 365            
 Pro Lys Ile Arg Arg Lys Lys Ser Leu Ser
     370                 375            



      <210> 630
      <211> 252
      <212> PRT
      <213> Homo sapiens


      <400> 630
 Met Glu Asp Gly Lys Arg Glu Arg Trp Pro Thr Leu Met Glu Arg Leu
   1               5                  10                  15    
 Cys Ser Asp Gly Phe Ala Phe Pro Gln Tyr Pro Ile Lys Pro Tyr His
              20                  25                  30        
 Leu Asn Arg Ile His Arg Ala Val Leu His Gly Asn Leu Glu Lys Leu
          35                  40                  45            
 Lys Tyr Leu Leu Leu Thr Tyr Tyr Asp Ala Asn Lys Arg Asp Arg Lys
      50                  55                  60                
 Glu Arg Thr Ala Leu His Leu Ala Cys Ala Thr Gly Gln Pro Glu Met
  65                  70                  75                  80
 Val His Leu Leu Val Ser Arg Arg Cys Glu Leu Asn Leu Cys Asp Arg
                  85                  90                  95    
 Glu Asp Arg Thr Pro Leu Ile Lys Ala Val Gln Leu Arg Gln Glu Ala
             100                 105                 110        
 Cys Ala Thr Leu Leu Leu Gln Asn Gly Ala Asp Pro Asn Ile Thr Asp
         115                 120                 125            
 Val Phe Gly Arg Thr Ala Leu Gln Leu Arg Trp Cys Ile Met Lys Asp
     130                 135                 140                
 Thr Ser Met Ile Glu Lys Leu Leu Ser His Gly Thr Asn Ile Glu Glu
 145                 150                 155                 160
 Cys Ser Lys Asn Glu Tyr Gln Pro Leu Leu Leu Ala Val Ser Arg Arg
                 165                 170                 175    
 Lys Val Lys Met Val Glu Phe Leu Leu Lys Lys Lys Ala Asn Val Asn
             180                 185                 190        
 Ala Ile Asp Tyr Leu Gly Arg Ser Ala Leu Ile Leu Ala Val Thr Leu
         195                 200                 205            
 Gly Glu Lys Asp Ile Val Ile Leu Leu Leu Gln His Asn Ile Asp Val
     210                 215                 220                
 Phe Ser Arg Asp Val Tyr Gly Lys Leu Ala Glu Asp Tyr Ala Ser Glu
 225                 230                 235                 240
 Ala Glu Asn Arg Val Val Ser Ser Glu Thr Thr Ser
                 245                 250        



      <210> 631
      <211> 265
      <212> PRT
      <213> Homo sapiens


      <400> 631
 Met Glu Ile Cys Pro Gly Glu Gly Arg Val Ser Ala Gln Thr Glu Pro
   1               5                  10                  15    
 Arg Glu Asp Val Phe Gly Asp Val Ser Pro Arg Lys Val Trp Ala Ala
              20                  25                  30        
 Phe Leu Thr Leu Asp Ala Cys Gly Leu Pro Ser Ser Pro Trp Met Pro
          35                  40                  45            
 Val Gly Cys Leu Pro His Pro Gly Cys Leu Trp Ala Ala Phe Leu Thr
      50                  55                  60                
 Leu Asp Ala Cys Gly Leu Pro Ser Ser Pro Trp Met Pro Val Gly Cys
  65                  70                  75                  80
 Leu Pro His Pro Gly Cys Leu Trp Ala Ala Phe Leu Thr Leu Asp Ala
                  85                  90                  95    
 Cys Gly Leu Pro Ser Ser Pro Trp Met Pro Val Gly Ser Leu Pro His
             100                 105                 110        
 Pro Gly Cys Leu Trp Ala Ala Phe Leu Thr Leu Asp Ala Cys Gly Gln
         115                 120                 125            
 Pro Ser Ser Pro Trp Met Pro Val Gly Cys Leu Pro His Pro Gly Cys
     130                 135                 140                
 Leu Trp Ala Ala Phe Leu Thr Leu Asp Ala Cys Gly Gln Pro Ser Ser
 145                 150                 155                 160
 Pro Trp Met Pro Val Thr Trp Phe Pro Trp Gly Leu Pro Lys Leu Arg
                 165                 170                 175    
 Asp Pro Lys Pro Pro Ser Asn Leu Met Thr Arg Pro Val Ser Glu His
             180                 185                 190        
 Thr Cys Val Val Pro Glu Pro Leu Thr Asn Pro Leu Cys Asn Pro Ala
         195                 200                 205            
 His Ala Phe Pro Ile Leu Lys Gly Pro Ala His Arg Pro Ala His Val
     210                 215                 220                
 Phe Pro Leu Pro Leu Leu Cys Pro Tyr Leu Val Gly Ser Cys Pro Phe
 225                 230                 235                 240
 Trp Ala Leu Val Trp His Phe Thr His Lys Cys Val Leu Trp Val Val
                 245                 250                 255    
 Ser Gly Pro Pro Pro Ala Val Arg Gly
             260                 265



      <210> 632
      <211> 866
      <212> PRT
      <213> Homo sapiens


      <400> 632
 Met Glu Ile Pro Lys Asp Ser Leu Gln Lys Tyr Leu Lys Asp Leu Leu
   1               5                  10                  15    
 Gly Ile Gln Thr Thr Gly Pro Leu Glu Leu Leu Gln Phe Asp His Gly
              20                  25                  30        
 Gln Ser Asn Pro Thr Tyr Tyr Ile Arg Leu Ala Asn Arg Asp Leu Val
          35                  40                  45            
 Leu Arg Lys Lys Pro Pro Gly Thr Leu Leu Pro Ser Ala His Ala Ile
      50                  55                  60                
 Glu Arg Glu Phe Arg Ile Met Lys Ala Leu Ala Asn Ala Gly Val Pro
  65                  70                  75                  80
 Val Pro Asn Val Leu Asp Leu Cys Glu Asp Ser Ser Val Ile Gly Thr
                  85                  90                  95    
 Pro Phe Tyr Val Met Glu Tyr Cys Pro Gly Leu Ile Tyr Lys Asp Pro
             100                 105                 110        
 Ser Leu Pro Gly Leu Glu Pro Ser His Arg Arg Ala Ile Tyr Thr Ala
         115                 120                 125            
 Met Asn Thr Val Leu Cys Lys Ile His Ser Val Asp Leu Gln Ala Val
     130                 135                 140                
 Gly Leu Glu Asp Tyr Gly Lys Gln Gly Asp Tyr Ile Pro Arg Gln Val
 145                 150                 155                 160
 Arg Thr Trp Val Lys Gln Tyr Arg Ala Ser Glu Thr Ser Thr Ile Pro
                 165                 170                 175    
 Ala Met Glu Arg Leu Ile Glu Trp Leu Pro Leu His Leu Pro Arg Gln
             180                 185                 190        
 Gln Arg Thr Thr Val Val His Gly Asp Phe Arg Leu Asp Asn Leu Val
         195                 200                 205            
 Phe His Pro Glu Glu Pro Glu Val Leu Ala Val Leu Asp Trp Glu Leu
     210                 215                 220                
 Ser Thr Leu Gly Asp Pro Leu Ala Asp Val Ala Tyr Ser Cys Leu Ala
 225                 230                 235                 240
 His Tyr Leu Pro Ser Ser Phe Pro Val Leu Arg Gly Ile Asn Asp Cys
                 245                 250                 255    
 Asp Leu Thr Gln Leu Gly Ile Pro Ala Ala Glu Glu Tyr Phe Arg Met
             260                 265                 270        
 Tyr Cys Leu Gln Met Gly Leu Pro Pro Thr Glu Asn Trp Asn Phe Tyr
         275                 280                 285            
 Met Ala Phe Ser Phe Phe Arg Val Ala Ala Ile Leu Gln Gly Val Tyr
     290                 295                 300                
 Lys Arg Ser Leu Thr Gly Gln Ala Ser Ser Thr Tyr Ala Glu Gln Thr
 305                 310                 315                 320
 Gly Lys Leu Thr Glu Phe Val Ser Asn Leu Ala Trp Asp Phe Ala Val
                 325                 330                 335    
 Lys Glu Gly Phe Arg Val Phe Lys Glu Met Pro Phe Thr Asn Pro Leu
             340                 345                 350        
 Thr Arg Ser Tyr His Thr Trp Ala Arg Pro Gln Ser Gln Trp Cys Pro
         355                 360                 365            
 Thr Gly Ser Arg Ser Tyr Ser Ser Val Pro Glu Ala Ser Pro Ala His
     370                 375                 380                
 Thr Ser Arg Gly Gly Leu Val Ile Ser Pro Glu Ser Leu Ser Pro Pro
 385                 390                 395                 400
 Val Arg Glu Leu Tyr His Arg Leu Lys His Phe Met Glu Gln Arg Val
                 405                 410                 415    
 Tyr Pro Ala Glu Pro Glu Leu Gln Ser His Gln Ala Ser Ala Ala Arg
             420                 425                 430        
 Trp Ser Pro Ser Pro Leu Ile Glu Asp Leu Lys Glu Lys Ala Lys Ala
         435                 440                 445            
 Glu Gly Leu Trp Asn Leu Phe Leu Pro Leu Glu Ala Asp Pro Glu Lys
     450                 455                 460                
 Lys Tyr Gly Ala Gly Leu Thr Asn Val Glu Tyr Ala His Leu Cys Glu
 465                 470                 475                 480
 Leu Met Gly Thr Ser Leu Tyr Ala Pro Glu Val Cys Asn Cys Ser Ala
                 485                 490                 495    
 Pro Asp Thr Gly Asn Met Glu Leu Leu Val Arg Tyr Gly Thr Glu Ala
             500                 505                 510        
 Gln Lys Ala Arg Trp Leu Ile Pro Leu Leu Glu Gly Lys Ala Arg Ser
         515                 520                 525            
 Cys Phe Ala Met Thr Glu Pro Gln Val Ala Ser Ser Asp Ala Thr Asn
     530                 535                 540                
 Ile Glu Ala Ser Ile Arg Glu Glu Asp Ser Phe Tyr Val Ile Asn Gly
 545                 550                 555                 560
 His Lys Trp Trp Ile Thr Gly Ile Leu Asp Pro Arg Cys Gln Leu Cys
                 565                 570                 575    
 Val Phe Met Gly Lys Thr Asp Pro His Ala Pro Arg His Arg Gln Gln
             580                 585                 590        
 Ser Val Leu Leu Val Pro Met Asp Thr Pro Gly Ile Lys Ile Ile Arg
         595                 600                 605            
 Pro Leu Thr Val Tyr Gly Leu Glu Asp Ala Pro Gly Gly His Gly Glu
     610                 615                 620                
 Val Arg Phe Glu His Val Arg Val Pro Lys Glu Asn Met Val Leu Gly
 625                 630                 635                 640
 Pro Gly Arg Gly Phe Glu Ile Ala Gln Gly Arg Leu Gly Pro Gly Arg
                 645                 650                 655    
 Ile His His Cys Met Arg Leu Ile Gly Phe Ser Glu Arg Ala Leu Ala
             660                 665                 670        
 Leu Met Lys Ala Arg Val Lys Ser Arg Leu Ala Phe Gly Lys Pro Leu
         675                 680                 685            
 Val Glu Gln Gly Thr Val Leu Ala Asp Ile Ala Gln Ser Arg Val Glu
     690                 695                 700                
 Ile Glu Gln Ala Arg Leu Leu Val Leu Arg Ala Ala His Leu Met Asp
 705                 710                 715                 720
 Leu Ala Gly Asn Lys Ala Ala Ala Leu Asp Ile Ala Met Ile Lys Met
                 725                 730                 735    
 Val Ala Pro Ser Met Ala Ser Arg Val Ile Asp Arg Ala Ile Gln Lys
             740                 745                 750        
 Thr Ser Leu Gln Glu Ala Trp Ser Leu Phe Gln Ala Arg Arg Arg Gly
         755                 760                 765            
 Phe Ala Glu Gly Gln Gly Gly Ser Gly Thr Glu Ser Gly Lys Leu Val
     770                 775                 780                
 Phe Arg Leu Ser Val Pro Gly Trp Ala Gly Thr Val Thr Ser Leu Gln
 785                 790                 795                 800
 Pro Phe Ser Pro Ser Leu Ser Ala Cys Gly Asn Leu Asp Thr Phe Trp
                 805                 810                 815    
 Glu Ala Ser Gln Gly Cys Gly Thr Cys Leu Leu Trp Gln Leu Gln Gly
             820                 825                 830        
 Ser Cys Leu Ala Ser Leu Val Ser Arg Gly Ala Ala Thr Ala Gly Gly
         835                 840                 845            
 Gly Leu Glu Thr Gln Asp Leu Gly Ala Trp Glu Asn Gly Met Gln Pro
     850                 855                 860                
 Thr Leu
 865    



      <210> 633
      <211> 161
      <212> PRT
      <213> Homo sapiens


      <400> 633
 Met Gly Arg Met His Ala Pro Gly Lys Gly Leu Ser Gln Ser Ala Leu
   1               5                  10                  15    
 Pro Tyr Arg Arg Ser Val Pro Thr Trp Leu Lys Leu Thr Ser Asp Asp
              20                  25                  30        
 Val Lys Glu Gln Ile Tyr Lys Leu Ala Lys Lys Gly Leu Thr Pro Ser
          35                  40                  45            
 Gln Ile Gly Val Ile Leu Arg Asp Ser His Gly Val Ala Gln Val Arg
      50                  55                  60                
 Phe Val Thr Gly Asn Lys Ile Leu Arg Ile Leu Lys Ser Lys Gly Leu
  65                  70                  75                  80
 Ala Pro Asp Leu Pro Glu Asp Leu Tyr His Leu Ile Lys Lys Ala Val
                  85                  90                  95    
 Ala Val Arg Lys His Leu Glu Arg Asn Arg Lys Asp Lys Asp Ala Lys
             100                 105                 110        
 Phe Arg Leu Ile Leu Ile Glu Ser Arg Ile His Arg Leu Ala Arg Tyr
         115                 120                 125            
 Tyr Lys Thr Lys Arg Val Leu Pro Pro Asn Trp Lys Tyr Glu Ser Phe
     130                 135                 140                
 Tyr Cys Leu Ser Thr Gln Thr Asn Leu Cys Asp Gln Gly Arg Gly Cys
 145                 150                 155                 160
 Arg
    



      <210> 634
      <211> 178
      <212> PRT
      <213> Homo sapiens


      <400> 634
 Met Ser Trp Gly His Leu Leu Ser Leu Ile Asp Ala Glu Ser Ile Gln
   1               5                  10                  15    
 Lys Leu Pro Asp Gln Pro Ser His His Thr Gln Lys Arg Pro Phe Pro
              20                  25                  30        
 Ser Gly Glu Lys Leu Pro Asp Gln Pro Phe Thr His His Ser Gln Glu
          35                  40                  45            
 Gly Pro Phe Pro Pro Gly Glu Lys Leu Pro Asp Gln Pro Leu Ile Pro
      50                  55                  60                
 Gln Pro Arg Gly Ala Phe Leu Thr Trp Arg Glu Thr Ser Arg Pro Ala
  65                  70                  75                  80
 Pro His Thr Thr Ala Arg Arg Gly Leu Ser His Arg Glu Arg Asn Phe
                  85                  90                  95    
 Gln Thr Ser Pro Ser His His Ser Gln Asp Glu Ala Phe Pro Ala Trp
             100                 105                 110        
 Arg Glu Thr Ser Arg Pro Ala Leu Ser Leu Gln Pro Glu Glu Ala Phe
         115                 120                 125            
 Pro Thr Trp Arg Gly Thr Ser Arg Pro Ala Leu His Thr Pro Gln Pro
     130                 135                 140                
 Gly Glu Ala Phe Pro Ala Trp Gly Glu Ala Ser Arg Pro Ala Pro Leu
 145                 150                 155                 160
 Thr Thr Ala Arg Arg Gly Leu Phe Cys Leu Glu Arg Asn Ser Ser Asp
                 165                 170                 175    
 Gln Ala
        



      <210> 635
      <211> 341
      <212> PRT
      <213> Homo sapiens


      <400> 635
 Met Glu Cys Leu Arg Met Pro Val Gly Phe Trp Ser Gln Leu Trp Lys
   1               5                  10                  15    
 Gly Ala Glu Leu Arg Tyr Ser Leu Thr Glu Lys Gln Leu Ala Ala Val
              20                  25                  30        
 Tyr Ala Thr Leu Gln Ala His Asp Ser Met Thr Gly Trp Ala Ala Val
          35                  40                  45            
 Ile Ile Trp Thr Thr Tyr Pro Ile Thr Gly Trp Met Arg Leu Cys Val
      50                  55                  60                
 Met Thr Thr Trp Ser Gly Ile Ala Gln Met Ser Thr Leu Ala Lys Trp
  65                  70                  75                  80
 Gly Asn Ser Leu Gln Gln Trp Ser Lys Leu Ser Thr Ser Pro Ile Ala
                  85                  90                  95    
 Ala Glu Leu Gln Glu Ile Leu Gly Pro Val Val Leu Met Gln Asp Lys
             100                 105                 110        
 Ala Met Arg Pro Glu Ala Pro Leu Asp Pro Glu Ser Ser Pro Phe Lys
         115                 120                 125            
 Glu Gly His Pro Arg Ile Pro Glu Gly Ala Trp Tyr Thr Val Asp Glu
     130                 135                 140                
 Val Leu Leu Leu Pro Gly Pro Leu Leu Gln Ser Asn Leu Val Leu Thr
 145                 150                 155                 160
 Pro Tyr Gly Leu Lys Leu Gly His Met Pro Leu Ala Thr Pro Ser Asn
                 165                 170                 175    
 Asp Glu Ala Asp Ala Leu Ala Lys Val Arg Trp Ser Glu Ser Ala Pro
             180                 185                 190        
 Thr Gln Asp Val Thr Leu Trp Leu His Arg Lys Leu Gly His Ala Gly
         195                 200                 205            
 Gly Lys Leu Met Gln Gln Phe Asn Lys Cys Trp Gly Leu Ser Leu Pro
     210                 215                 220                
 Lys Gln Asp Ile Cys Glu Ala Cys Gln Lys Cys Leu Ala Cys Val Gln
 225                 230                 235                 240
 Thr Tyr Pro Lys Lys Arg Gln Leu Pro Gly Val Ile Gln Gln Val Thr
                 245                 250                 255    
 Ile Gly Val Ala Asn Gln Gln Asn Thr Ile Gln Ala Leu Gln His Leu
             260                 265                 270        
 Cys Ser Leu Tyr Gly Cys Pro Leu Ala Ile Glu Ser Asp Arg Gly Thr
         275                 280                 285            
 His Phe Thr Gly Gln Gln Asn Pro Asp Leu Pro Lys Thr Asn Asn Ile
     290                 295                 300                
 Ala Phe Pro Glu Phe Ser Leu Thr Glu Leu Leu Leu Gln Lys Glu Arg
 305                 310                 315                 320
 Leu Lys Ser Leu Asn Thr Thr Asp Phe Cys His Thr Ala Leu Gln Ala
                 325                 330                 335    
 Gln Gln Thr Leu Ser
             340    



      <210> 636
      <211> 317
      <212> PRT
      <213> Homo sapiens


      <400> 636
 Met Lys Glu Ser Arg Leu Pro Leu Pro Glu Leu Pro Ser Gly Cys Leu
   1               5                  10                  15    
 Val Leu Gln Val Gln Glu Leu Val Gln Met Ser Gly Met Glu Ala Thr
              20                  25                  30        
 Val Thr Ile Pro Ile Trp Gln Asn Lys Pro His Gly Ala Ala Arg Ser
          35                  40                  45            
 Val Val Arg Arg Ile Gly Thr Asn Leu Pro Leu Lys Pro Cys Ala Arg
      50                  55                  60                
 Ala Ser Phe Glu Thr Leu Pro Asn Ile Ser Asp Leu Cys Leu Arg Asp
  65                  70                  75                  80
 Val Pro Pro Val Pro Thr Leu Ala Asp Ile Ala Trp Ile Ala Ala Asp
                  85                  90                  95    
 Glu Glu Glu Thr Tyr Ala Arg Val Arg Ser Asp Thr Arg Pro Leu Arg
             100                 105                 110        
 His Thr Trp Lys Pro Ser Pro Leu Ile Val Met Gln Arg Asn Ala Ser
         115                 120                 125            
 Val Pro Asn Leu Arg Gly Ser Glu Glu Arg Leu Leu Ala Leu Lys Lys
     130                 135                 140                
 Pro Ala Leu Pro Ala Leu Ser Arg Thr Thr Glu Leu Gln Asp Glu Leu
 145                 150                 155                 160
 Ser His Leu Arg Ser Gln Ile Ala Lys Ile Val Ala Ala Asp Ala Ala
                 165                 170                 175    
 Ser Ala Ser Leu Thr Pro Asp Phe Leu Ser Pro Gly Ser Ser Asn Val
             180                 185                 190        
 Ser Ser Pro Leu Pro Cys Phe Gly Ser Ser Phe His Ser Thr Thr Ser
         195                 200                 205            
 Phe Val Ile Ser Asp Ile Thr Glu Glu Thr Glu Val Glu Val Pro Glu
     210                 215                 220                
 Leu Pro Ser Val Pro Leu Leu Cys Ser Ala Ser Pro Glu Cys Cys Lys
 225                 230                 235                 240
 Pro Glu His Lys Ala Ala Cys Ser Ser Ser Glu Glu Asp Asp Cys Val
                 245                 250                 255    
 Ser Leu Ser Lys Ala Ser Ser Phe Ala Asp Met Met Gly Ile Leu Lys
             260                 265                 270        
 Asp Phe His Arg Met Lys Gln Ser Gln Asp Leu Asn Arg Ser Leu Leu
         275                 280                 285            
 Lys Glu Glu Asp Pro Ala Val Leu Ile Ser Glu Val Leu Arg Arg Lys
     290                 295                 300                
 Phe Ala Leu Lys Glu Glu Asp Ile Ser Arg Lys Gly Asn
 305                 310                 315        



      <210> 637
      <211> 978
      <212> PRT
      <213> Homo sapiens


      <400> 637
 Met Leu Gly Glu Met Met Phe Gly Ser Val Ala Met Ser Tyr Lys Gly
   1               5                  10                  15    
 Ser Thr Leu Lys Ile His Tyr Ile Arg Ser Pro Pro Gln Leu Met Ile
              20                  25                  30        
 Ser Lys Val Phe Ser Ala Arg Met Gly Ser Phe Cys Gly Ser Thr Asn
          35                  40                  45            
 Asn Leu Gln Asp Ser Phe Glu Tyr Ile Asn Gln Asp Pro Asn Leu Gly
      50                  55                  60                
 Lys Leu Asn Thr Asn Gln Asn Ser Leu Gly Pro Cys Arg Thr Gly Ser
  65                  70                  75                  80
 Asn Leu Ala His Ser Thr Pro Val Asp Met Pro Ser Arg Gly Gln Asn
                  85                  90                  95    
 Glu Asp Arg Asp Ser Gly Ile Ala Arg Ser Ala Ser Leu Ser Ser Leu
             100                 105                 110        
 Leu Ile Thr Pro Phe Pro Ser Pro Ser Ser Ser Thr Ser Ser Ser Ser
         115                 120                 125            
 Ser Tyr Gln Arg Arg Trp Leu Arg Ser Gln Thr Thr Ser Leu Glu Asn
     130                 135                 140                
 Gly Ile Ile Pro Arg Arg Ser Thr Asp Glu Thr Phe Ser Leu Ala Glu
 145                 150                 155                 160
 Glu Thr Cys Ser Ser Asn Pro Ala Met Val Arg Arg Lys Lys Ile Ala
                 165                 170                 175    
 Ile Ser Ile Ile Phe Ser Leu Cys Glu Lys Glu Glu Ala Gln Arg Asn
             180                 185                 190        
 Phe Gln Asp Phe Phe Phe Ser His Phe Pro Leu Phe Glu Ser His Met
         195                 200                 205            
 Asn Arg Leu Lys Ser Ala Ile Glu Lys Ala Met Ile Ser Cys Arg Lys
     210                 215                 220                
 Ile Ala Glu Ser Ser Leu Arg Val Gln Phe Tyr Val Ser Arg Leu Met
 225                 230                 235                 240
 Glu Ala Leu Gly Glu Phe Arg Gly Thr Ile Trp Asn Leu Tyr Ser Val
                 245                 250                 255    
 Pro Arg Ile Ala Glu Pro Val Trp Leu Thr Met Met Ser Gly Thr Leu
             260                 265                 270        
 Glu Lys Asn Gln Leu Cys Gln Arg Phe Leu Lys Glu Phe Thr Leu Leu
         275                 280                 285            
 Ile Glu Gln Ile Asn Lys Asn Gln Phe Phe Ala Ala Leu Leu Thr Ala
     290                 295                 300                
 Val Leu Thr Tyr His Leu Ala Trp Val Pro Thr Val Met Pro Val Asp
 305                 310                 315                 320
 His Pro Pro Ile Lys Ala Phe Ser Glu Lys Arg Thr Ser Gln Ser Val
                 325                 330                 335    
 Asn Met Leu Ala Lys Thr His Pro Tyr Asn Pro Leu Trp Ala Gln Leu
             340                 345                 350        
 Gly Asp Leu Tyr Gly Ala Ile Gly Ser Pro Val Arg Leu Thr Arg Thr
         355                 360                 365            
 Val Val Val Gly Lys Gln Lys Asp Leu Val Gln Arg Ile Leu Tyr Val
     370                 375                 380                
 Leu Thr Tyr Phe Leu Arg Cys Ser Glu Leu Gln Glu Asn Gln Leu Thr
 385                 390                 395                 400
 Trp Ser Gly Asn His Gly Glu Gly Asp Gln Val Leu Asn Gly Ser Lys
                 405                 410                 415    
 Ile Ile Thr Ala Leu Glu Lys Gly Glu Val Glu Glu Ser Glu Tyr Val
             420                 425                 430        
 Val Ile Thr Val Arg Asn Glu Pro Ala Leu Val Pro Pro Ile Leu Pro
         435                 440                 445            
 Pro Thr Ala Ala Glu Arg His Asn Pro Trp Pro Thr Gly Phe Pro Glu
     450                 455                 460                
 Cys Pro Glu Gly Thr Asp Ser Arg Asp Leu Gly Leu Lys Pro Asp Lys
 465                 470                 475                 480
 Glu Ala Asn Arg Arg Pro Glu Gln Gly Ser Glu Ala Cys Ser Ala Gly
                 485                 490                 495    
 Cys Leu Gly Pro Ala Ser Asp Ala Ser Trp Lys Pro Gln Asn Ala Phe
             500                 505                 510        
 Cys Gly Asp Glu Lys Asn Lys Glu Ala Pro Gln Asp Gly Ser Ser Arg
         515                 520                 525            
 Leu Pro Ser Cys Glu Val Leu Gly Ala Gly Met Lys Met Asp Gln Gln
     530                 535                 540                
 Ala Val Cys Glu Leu Leu Lys Val Glu Met Pro Thr Arg Leu Pro Asp
 545                 550                 555                 560
 Arg Ser Val Ala Trp Pro Cys Pro Asp Arg His Leu Arg Glu Lys Pro
                 565                 570                 575    
 Ser Leu Glu Lys Val Thr Phe Gln Ile Gly Ser Phe Ala Ser Pro Glu
             580                 585                 590        
 Ser Asp Phe Glu Ser Arg Met Lys Lys Met Glu Glu Arg Val Lys Ala
         595                 600                 605            
 Cys Gly Pro Ser Leu Glu Ala Ser Glu Ala Ala Asp Val Ala Gln Asp
     610                 615                 620                
 Pro Gln Val Ser Arg Ser Pro Phe Lys Pro Gly Phe Gln Glu Asn Val
 625                 630                 635                 640
 Cys Cys Pro Gln Asn Arg Leu Ser Glu Gly Asp Glu Gly Glu Ser Asp
                 645                 650                 655    
 Lys Gly Phe Ala Glu Asp Arg Gly Ser Arg Asn Asp Met Ala Ala Asp
             660                 665                 670        
 Ile Ala Gly Gln Leu Ser His Ala Ala Asp Leu Gly Thr Ala Ser His
         675                 680                 685            
 Gly Ala Gly Gly Thr Gly Gly Arg Arg Leu Glu Ala Thr Arg Gly Leu
     690                 695                 700                
 Tyr Val Lys Ala Ala Glu Gly Pro Val Leu Glu Pro Val Ala Pro Arg
 705                 710                 715                 720
 Cys Val Gln Arg Gly Pro Gly Leu Val Ala Gly Ala Asn Ile Pro Cys
                 725                 730                 735    
 Gly Asp Asp Asn Lys Lys Ala Asn Phe Arg Thr Glu Gly Asp Ile Pro
             740                 745                 750        
 Arg Asn Glu Ser Ser Asp Ser Ala Leu Gly Asp Ser Asp Asp Glu Ala
         755                 760                 765            
 Cys Ala Ser Ala Met Leu Asp Leu Gly His Gly Gly Asp Arg Thr Gly
     770                 775                 780                
 Gly Ser Leu Glu Val Glu Leu Pro Leu Pro Arg Ser Gln Ser Ile Ser
 785                 790                 795                 800
 Thr Gln Asn Val Arg Asn Phe Gly Arg Ser Leu Leu Ala Gly Tyr Cys
                 805                 810                 815    
 Pro Thr Tyr Met Pro Asp Leu Val Leu His Gly Thr Gly Ser Asp Glu
             820                 825                 830        
 Lys Leu Lys Gln Cys Leu Val Ala Asp Leu Val His Thr Val His His
         835                 840                 845            
 Pro Val Leu Asp Glu Pro Ile Ala Glu Ala Val Cys Ile Ile Ala Asp
     850                 855                 860                
 Thr Asp Lys Trp Ser Val Gln Val Ala Thr Ser Gln Arg Lys Val Thr
 865                 870                 875                 880
 Asp Asn Met Lys Leu Gly Gln Asp Val Leu Val Ser Ser Gln Val Ser
                 885                 890                 895    
 Ser Leu Leu Gln Ser Ile Leu Gln Leu Tyr Lys Leu His Leu Pro Ala
             900                 905                 910        
 Asp Phe Cys Ile Met His Leu Glu Asp Arg Leu Gln Glu Met Tyr Leu
         915                 920                 925            
 Lys Ser Lys Met Leu Ser Glu Tyr Leu Arg Gly His Thr Arg Val His
     930                 935                 940                
 Val Lys Glu Leu Gly Val Val Leu Gly Ile Glu Ser Asn Asp Leu Pro
 945                 950                 955                 960
 Leu Leu Thr Ala Ile Ala Ser Thr His Ser Pro Tyr Val Ala Gln Ile
                 965                 970                 975    
 Leu Leu
        



      <210> 638
      <211> 232
      <212> PRT
      <213> Homo sapiens


      <400> 638
 Met Glu Asn Pro Leu Pro Asp Thr Val Leu Arg Val Asp Thr Arg Arg
   1               5                  10                  15    
 Ile Arg Ser Arg His Thr Leu Pro Thr Met Asp Asn Trp Arg Ile Leu
              20                  25                  30        
 Leu Ala Thr His Val Leu Pro Trp Thr Leu Glu Ile Leu Leu Leu Thr
          35                  40                  45            
 His Val Pro Pro Trp Ile Leu Glu Asn Pro Ser Cys His Thr Arg Pro
      50                  55                  60                
 Ala Val Asp Thr Gly Glu Ser Phe Ser Pro His Thr Ser His Arg Gly
  65                  70                  75                  80
 His Trp Arg Ile Leu Leu Ala Thr His Ile Leu Pro Trp Thr Leu Glu
                  85                  90                  95    
 Asn Pro Ser Thr His Thr Arg Pro Ala Val Asp Thr Gly Glu Ser Phe
             100                 105                 110        
 Ser Pro His Thr Ser Cys His Gly His Arg Arg Ile His Leu His Thr
         115                 120                 125            
 Cys Pro Ala Val Asp Thr Gly Glu Ser Phe Leu Pro His Thr Ser Ser
     130                 135                 140                
 Arg Gly His Trp Arg Ile His Leu His Thr Arg Ile Leu Leu Trp Thr
 145                 150                 155                 160
 Leu Glu Asn Pro Ser Ala His Thr Arg Pro Ala Val Lys Thr Ser Thr
                 165                 170                 175    
 Leu Pro Phe Arg Phe Cys Ser Gln Leu Ser Phe Gln Tyr Ala Ala Trp
             180                 185                 190        
 Val Lys Gln Pro His Leu His Cys Pro Asn Asp Lys Arg His Gln His
         195                 200                 205            
 Cys Leu Thr Ser Phe Pro Pro Pro Leu Gln Ser Val Thr Phe Leu Ile
     210                 215                 220                
 Asp Arg Asp Phe Arg Phe Ser Ile
 225                 230        



      <210> 639
      <211> 180
      <212> PRT
      <213> Homo sapiens


      <400> 639
 Met Gly Lys His Lys Arg Thr Arg Lys Tyr Ala Thr Met Lys Arg Met
   1               5                  10                  15    
 Leu Ser Leu Arg Asp Gln Arg Leu Lys Glu Lys Asp Arg Leu Lys Pro
              20                  25                  30        
 Lys Lys Lys Glu Lys Lys Asp Pro Ser Ala Leu Lys Glu Arg Glu Val
          35                  40                  45            
 Pro Gln His Pro Ser Cys Leu Phe Phe Gln Tyr Asn Thr Gln Leu Gly
      50                  55                  60                
 Pro Pro Tyr His Ile Leu Val Asp Thr Asn Phe Ile Asn Phe Ser Ile
  65                  70                  75                  80
 Lys Ala Lys Leu Asp Leu Val Gln Ser Met Met Asp Cys Leu Tyr Ala
                  85                  90                  95    
 Lys Cys Ile Pro Cys Ile Thr Asp Cys Val Met Ala Glu Ile Glu Lys
             100                 105                 110        
 Leu Gly His Lys Tyr Arg Val Ala Leu Arg Ile Ala Lys Asp Pro Arg
         115                 120                 125            
 Phe Glu Arg Leu Pro Cys Thr His Lys Gly Thr Tyr Ala Asp Asp Cys
     130                 135                 140                
 Leu Val Gln Arg Val Thr Gln His Lys Cys Tyr Ile Val Ala Thr Val
 145                 150                 155                 160
 Asp Arg Asp Leu Arg Tyr Asn Ile Glu Arg Met Pro His Asp Tyr Gly
                 165                 170                 175    
 Ala Pro Arg Phe
             180



      <210> 640
      <211> 96
      <212> PRT
      <213> Homo sapiens


      <400> 640
 Met Pro Gly Pro Thr Ala Ser Gly Thr Asn Val Gly Ser Ser Gly Arg
   1               5                  10                  15    
 Ser Pro Ser Lys Ala Val Ala Ala Arg Ala Ala Gly Ser Thr Val Arg
              20                  25                  30        
 His Arg Lys Asn Ala Ser Cys Gly Thr Arg Ser Ala Gly Arg Thr Thr
          35                  40                  45            
 Ser Ala Gly Thr Gly Gly Met Trp Arg Phe Tyr Thr Glu Asp Ser Pro
      50                  55                  60                
 Gly Leu Lys Asp Gly Pro Val Pro Gly Leu Asp Met Arg Leu Leu Phe
  65                  70                  75                  80
 Ile Ala Ser Val Phe Met Leu His Ile Trp Gly Lys Tyr Thr Arg Ser
                  85                  90                  95    





      <210> 641
      <211> 224
      <212> PRT
      <213> Homo sapiens


      <400> 641
 Met Ala Ser Ala Met Lys Ala Val Thr Glu Leu Asn Glu Pro Leu Ser
   1               5                  10                  15    
 Asn Glu Asp Arg Asn Leu Leu Ser Val Ala Tyr Lys Asn Val Val Gly
              20                  25                  30        
 Ala Arg Arg Ser Ser Trp Arg Val Ile Ser Ser Ile Glu Gln Lys Thr
          35                  40                  45            
 Met Ala Asp Gly Asn Glu Lys Lys Leu Glu Lys Val Lys Ala Tyr Arg
      50                  55                  60                
 Glu Lys Ile Glu Lys Glu Leu Glu Thr Val Cys Asn Asp Val Leu Ser
  65                  70                  75                  80
 Leu Leu Asp Lys Phe Leu Ile Lys Asn Cys Asn Asp Phe Gln Tyr Glu
                  85                  90                  95    
 Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr Arg Tyr Leu
             100                 105                 110        
 Ala Glu Val Ala Ser Gly Glu Lys Lys Asn Ser Val Val Glu Ala Ser
         115                 120                 125            
 Glu Ala Ala Tyr Lys Glu Ala Phe Glu Ile Ser Lys Glu Gln Met Gln
     130                 135                 140                
 Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val Phe
 145                 150                 155                 160
 Tyr Tyr Glu Ile Gln Asn Ala Pro Ala Arg Thr Pro Leu Leu Asp Gln
                 165                 170                 175    
 Lys Ala Leu Gly Phe Arg Arg Ala Glu Leu Asp Thr Leu Asn Glu Asp
             180                 185                 190        
 Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn Leu
         195                 200                 205            
 Thr Leu Trp Thr Ser Asp Gln Gln Asp Glu Glu Ala Gly Glu Gly Asn
     210                 215                 220                





      <210> 642
      <211> 230
      <212> PRT
      <213> Homo sapiens


      <400> 642
 Met Asp Cys Arg Glu Met Asp Leu Tyr Glu Asp Tyr Gln Ser Pro Phe
   1               5                  10                  15    
 Asp Phe Asp Ala Gly Val Asn Lys Ser Tyr Leu Tyr Leu Ser Pro Ser
              20                  25                  30        
 Gly Asn Ser Ser Pro Pro Gly Ser Pro Thr Leu Gln Lys Phe Gly Leu
          35                  40                  45            
 Leu Arg Thr Asp Pro Val Pro Glu Glu Gly Glu Asp Val Ala Ala Thr
      50                  55                  60                
 Ile Ser Ala Thr Glu Thr Leu Ser Glu Glu Glu Gln Glu Glu Leu Arg
  65                  70                  75                  80
 Arg Glu Leu Ala Lys Val Glu Glu Glu Ile Gln Thr Leu Ser Gln Val
                  85                  90                  95    
 Leu Ala Ala Lys Glu Lys His Leu Ala Glu Ile Lys Arg Lys Leu Gly
             100                 105                 110        
 Ile Asn Ser Leu Gln Glu Leu Lys Gln Asn Ile Ala Lys Gly Trp Gln
         115                 120                 125            
 Asp Val Thr Ala Thr Ser Ala Tyr Lys Lys Thr Ser Glu Thr Leu Ser
     130                 135                 140                
 Gln Ala Gly Gln Lys Ala Ser Ala Ala Phe Ser Ser Val Gly Ser Val
 145                 150                 155                 160
 Ile Thr Lys Lys Leu Glu Asp Val Lys Asn Ser Pro Thr Phe Lys Ser
                 165                 170                 175    
 Phe Glu Glu Lys Val Glu Asn Leu Lys Ser Lys Val Gly Gly Thr Lys
             180                 185                 190        
 Pro Ala Gly Gly Asp Phe Gly Glu Val Leu Asn Ser Ala Ala Asn Ala
         195                 200                 205            
 Ser Ala Thr Thr Thr Glu Pro Leu Pro Glu Lys Thr Gln Glu Ser Leu
     210                 215                 220                
 Pro Thr Leu Pro Pro Phe
 225                 230



      <210> 643
      <211> 171
      <212> PRT
      <213> Homo sapiens


      <400> 643
 Met Glu Glu Arg Gly Asp Ser Glu Pro Thr Pro Gly Cys Ser Gly Leu
   1               5                  10                  15    
 Gly Pro Gly Gly Val Arg Gly Phe Gly Asp Gly Gly Gly Ala Pro Ser
              20                  25                  30        
 Trp Ala Pro Glu Asp Ala Trp Met Gly Thr His Pro Lys Tyr Leu Glu
          35                  40                  45            
 Met Met Glu Leu Asp Ile Gly Asp Ala Thr Gln Val Tyr Val Ala Phe
      50                  55                  60                
 Leu Val Tyr Leu Asp Leu Met Glu Ser Lys Ser Trp His Glu Val Asn
  65                  70                  75                  80
 Cys Val Gly Leu Pro Glu Leu Gln Leu Ile Cys Leu Val Gly Thr Glu
                  85                  90                  95    
 Ile Glu Gly Glu Gly Leu Gln Thr Val Val Pro Thr Pro Ile Thr Ala
             100                 105                 110        
 Ser Leu Ser His Asn Arg Ile Arg Glu Ile Leu Lys Ala Ser Arg Lys
         115                 120                 125            
 Leu Gln Gly Asp Pro Asp Leu Pro Met Ser Phe Thr Leu Ala Ile Val
     130                 135                 140                
 Glu Ser Asp Ser Thr Ile Val Tyr Tyr Lys Leu Thr Asp Gly Phe Met
 145                 150                 155                 160
 Leu Pro Asp Pro Gln Asn Ile Ser Leu Arg Arg
                 165                 170    



      <210> 644
      <211> 235
      <212> PRT
      <213> Homo sapiens


      <400> 644
 Met Arg His Ser Arg Gln Asp Ser Gly Thr Pro Arg Gln Val Asp Arg
   1               5                  10                  15    
 Val Val Gly Ser Leu Gly Met Ala Gln Asp Val Arg Ala His Gln Thr
              20                  25                  30        
 Ser Thr Pro Asn Ala Glu His Gly Arg Ala Pro Thr Ala Gly Ala Ser
          35                  40                  45            
 Pro Ala Pro Cys Val Cys Pro Ser Leu Pro Gln Val Asp Pro Tyr Leu
      50                  55                  60                
 Pro Tyr Glu Tyr Thr Cys Glu Gly Met Leu Glu Arg Ile His Ala Tyr
  65                  70                  75                  80
 Ile Gln His Gln Asp Phe Cys Arg Ala Pro Asp Pro Ala Leu Pro Glu
                  85                  90                  95    
 Ala His Ala Pro Gln Ser Pro Phe Val Leu Ala Pro Asn Ala Thr His
             100                 105                 110        
 Leu Glu Trp Ala Arg Asn Thr Ser Leu Ala Pro Gly Ala Trp Pro Pro
         115                 120                 125            
 Ala His Ala Leu Arg Ala Trp Leu Ala Val Pro Gly Arg Ala Cys Thr
     130                 135                 140                
 Asp Thr Cys Leu Asp His Gly Leu Ile Cys Glu Pro Ser Phe Phe Pro
 145                 150                 155                 160
 Phe Leu Asn Ser Gln Asp Ala Phe Leu Lys Leu Gln Val Pro Cys Asp
                 165                 170                 175    
 Ser Thr Glu Ser Glu Met Asn His Leu Tyr Pro Ala Phe Ala Gln Pro
             180                 185                 190        
 Gly Gln Glu Cys Tyr Leu Gln Lys Glu Pro Leu Leu Phe Ser Cys Ala
         195                 200                 205            
 Gly Ser Asn Thr Lys Tyr Arg Arg Leu Cys Pro Cys Arg Asp Phe Arg
     210                 215                 220                
 Lys Gly Gln Val Ala Leu Cys Gln Gly Cys Leu
 225                 230                 235



      <210> 645
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 645
 Met Arg Met Ile Ser Phe Ile Arg Ser Phe Cys Lys Tyr Arg Arg Phe
   1               5                  10                  15    
 Met Leu Asn Pro Ser Lys Arg Gln Glu Phe Glu Asp Tyr Leu His Gln
              20                  25                  30        
 Glu Met Gln Asn Ser Lys Glu Asn Phe Thr Thr Ala His Asn Thr Ser
          35                  40                  45            
 Gly Arg Ser Ala Pro Pro Ser Thr Asn Val Arg Ser Ala Asp Gln Glu
      50                  55                  60                
 Asn Gly Glu Ile Thr Leu Val Lys Arg Arg Ile Phe Gly His Arg Ile
  65                  70                  75                  80
 Ile Thr Val Asn Phe Ala Ile Asn Asp Leu Tyr Phe Phe Ser Glu Met
                  85                  90                  95    
 Glu Lys Phe Asn Asp Leu Val Ser Ser Ala His Met Leu Gln Val Asn
             100                 105                 110        
 Arg Ala Tyr Asn Glu Asn Asp Val Ile Leu Met Arg Ser Lys Met Asn
         115                 120                 125            
 Ile Ile Gln Lys Leu Phe Leu Asn Ser Asp Ile Pro Pro Lys Leu Arg
     130                 135                 140                
 Val Asn Val Pro Glu Phe Gln Arg Met Pro Ser Leu Leu Pro Ser Gln
 145                 150                 155                 160
 Arg Ala Thr
            



      <210> 646
      <211> 91
      <212> PRT
      <213> Homo sapiens


      <400> 646
 Met Leu Ile Phe Leu Gly Cys Tyr Arg Arg Arg Leu Glu Glu Arg Ala
   1               5                  10                  15    
 Gly Thr Met Ser Ala Glu Thr Ala Ser Gly Pro Thr Glu Asp Gln Val
              20                  25                  30        
 Glu Ile Leu Glu Tyr Asn Phe Asn Lys Val Asp Lys His Pro Asp Ser
          35                  40                  45            
 Thr Thr Leu Cys Leu Ile Ala Ala Glu Ala Gly Leu Ser Glu Glu Glu
      50                  55                  60                
 Thr Gln Lys Trp Phe Lys Gln Arg Leu Ala Lys Trp Arg Arg Ser Glu
  65                  70                  75                  80
 Gly Leu Pro Ser Glu Cys Arg Ser Val Thr Asp
                  85                  90    



      <210> 647
      <211> 801
      <212> PRT
      <213> Homo sapiens


      <400> 647
 Met Thr Val Glu Phe Glu Glu Cys Val Lys Asp Ser Pro Arg Phe Arg
   1               5                  10                  15    
 Ala Thr Ile Asp Glu Val Glu Thr Asp Val Val Glu Ile Glu Ala Lys
              20                  25                  30        
 Leu Asp Lys Leu Val Lys Leu Cys Ser Gly Met Val Glu Ala Gly Lys
          35                  40                  45            
 Ala Tyr Val Ser Thr Ser Arg Leu Phe Val Ser Gly Val Arg Asp Leu
      50                  55                  60                
 Ser Gln Gln Cys Gln Gly Asp Thr Val Ile Ser Glu Cys Leu Gln Arg
  65                  70                  75                  80
 Phe Ala Asp Ser Leu Gln Glu Val Val Asn Tyr His Met Ile Leu Phe
                  85                  90                  95    
 Asp Gln Ala Gln Arg Ser Val Arg Gln Gln Leu Gln Ser Phe Val Lys
             100                 105                 110        
 Glu Asp Val Arg Lys Phe Lys Glu Thr Lys Lys Gln Phe Asp Lys Val
         115                 120                 125            
 Arg Glu Asp Leu Glu Leu Ser Leu Val Arg Asn Ala Gln Ala Pro Arg
     130                 135                 140                
 His Arg Pro His Glu Val Glu Glu Ala Thr Gly Ala Leu Thr Leu Thr
 145                 150                 155                 160
 Arg Lys Cys Phe Arg His Leu Ala Leu Asp Tyr Val Leu Gln Ile Asn
                 165                 170                 175    
 Val Leu Gln Ala Lys Lys Lys Phe Glu Ile Leu Asp Ser Met Leu Ser
             180                 185                 190        
 Phe Met His Ala Gln Ser Ser Phe Phe Gln Gln Gly Tyr Ser Leu Leu
         195                 200                 205            
 His Gln Leu Asp Pro Tyr Met Lys Lys Leu Ala Ala Glu Leu Asp Gln
     210                 215                 220                
 Leu Val Ile Asp Ser Ala Val Glu Lys Arg Glu Met Glu Arg Lys His
 225                 230                 235                 240
 Ala Ala Ile Gln Gln Arg Thr Leu Leu Gln Asp Phe Ser Tyr Asp Glu
                 245                 250                 255    
 Ser Lys Val Glu Phe Asp Val Asp Ala Pro Ser Gly Val Val Met Glu
             260                 265                 270        
 Gly Tyr Leu Phe Lys Arg Ala Ser Asn Ala Phe Lys Thr Trp Asn Arg
         275                 280                 285            
 Arg Trp Phe Ser Ile Gln Asn Ser Gln Leu Val Tyr Gln Lys Lys Leu
     290                 295                 300                
 Lys Asp Ala Leu Thr Val Val Val Asp Asp Leu Arg Leu Cys Ser Val
 305                 310                 315                 320
 Lys Pro Cys Glu Asp Ile Glu Arg Arg Phe Cys Phe Glu Val Leu Ser
                 325                 330                 335    
 Pro Thr Lys Ser Cys Met Leu Gln Ala Asp Ser Glu Lys Leu Arg Gln
             340                 345                 350        
 Ala Trp Val Gln Ala Val Gln Ala Ser Ile Ala Ser Ala Tyr Arg Glu
         355                 360                 365            
 Ser Pro Asp Ser Cys Tyr Ser Glu Arg Leu Asp Arg Thr Ala Ser Pro
     370                 375                 380                
 Ser Thr Ser Ser Ile Asp Ser Ala Thr Asp Thr Arg Glu Arg Gly Val
 385                 390                 395                 400
 Lys Gly Glu Ser Val Leu Gln Arg Val Gln Ser Val Ala Gly Asn Ser
                 405                 410                 415    
 Gln Cys Gly Asp Cys Gly Gln Pro Asp Pro Arg Trp Ala Ser Ile Asn
             420                 425                 430        
 Leu Gly Val Leu Leu Cys Ile Glu Cys Ser Gly Ile His Arg Ser Leu
         435                 440                 445            
 Gly Val His Cys Ser Lys Val Arg Ser Leu Thr Leu Asp Ser Trp Glu
     450                 455                 460                
 Pro Glu Leu Leu Lys Leu Met Cys Glu Leu Gly Asn Ser Ala Val Asn
 465                 470                 475                 480
 Gln Ile Tyr Glu Ala Gln Cys Glu Gly Ala Gly Ser Arg Lys Pro Thr
                 485                 490                 495    
 Ala Ser Ser Ser Arg Gln Asp Lys Glu Ala Trp Ile Lys Asp Lys Tyr
             500                 505                 510        
 Val Glu Lys Lys Phe Leu Arg Lys Ala Pro Met Ala Pro Ala Leu Glu
         515                 520                 525            
 Ala Pro Arg Arg Trp Arg Val Gln Lys Cys Leu Arg Pro His Ser Ser
     530                 535                 540                
 Pro Arg Ala Pro Thr Ala Arg Arg Lys Val Arg Leu Glu Pro Val Leu
 545                 550                 555                 560
 Pro Cys Val Ala Ala Leu Ser Ser Val Gly Thr Leu Asp Arg Lys Phe
                 565                 570                 575    
 Arg Arg Asp Ser Leu Phe Cys Pro Asp Glu Leu Asp Ser Leu Phe Ser
             580                 585                 590        
 Tyr Phe Asp Ala Gly Ala Ala Gly Ala Gly Pro Arg Lys Gly Ala Glu
         595                 600                 605            
 Ser Glu Glu Ser Ser Gly Glu Ala Asp Gly Asp Thr Glu Ala Glu Ala
     610                 615                 620                
 Trp Gly Leu Ala Asp Val Arg Glu Leu His Pro Gly Leu Leu Ala His
 625                 630                 635                 640
 Arg Ala Ala Arg Ala Arg Asp Leu Pro Ala Leu Ala Ala Ala Leu Ala
                 645                 650                 655    
 His Gly Ala Glu Val Asn Trp Ala Asp Ala Glu Asp Glu Gly Lys Thr
             660                 665                 670        
 Pro Leu Val Gln Ala Val Leu Gly Gly Ser Leu Ile Val Cys Glu Phe
         675                 680                 685            
 Leu Leu Gln Asn Gly Ala Asp Val Asn Gln Arg Asp Ser Arg Gly Arg
     690                 695                 700                
 Ala Pro Leu His His Ala Thr Leu Leu Gly Arg Thr Gly Gln Val Cys
 705                 710                 715                 720
 Leu Phe Leu Lys Arg Gly Ala Asp Gln His Ala Leu Asp Gln Glu Gln
                 725                 730                 735    
 Arg Asp Pro Leu Ala Ile Ala Val Gln Ala Ala Asn Ala Asp Ile Val
             740                 745                 750        
 Thr Leu Leu Arg Leu Ala Arg Met Ala Glu Glu Met Arg Glu Ala Glu
         755                 760                 765            
 Ala Ala Pro Gly Pro Pro Gly Ala Leu Ala Gly Ser Pro Thr Glu Leu
     770                 775                 780                
 Gln Phe Arg Arg Cys Ile Gln Glu Phe Ile Ser Leu His Leu Glu Glu
 785                 790                 795                 800
 Ser
    



      <210> 648
      <211> 185
      <212> PRT
      <213> Homo sapiens


      <400> 648
 Met Glu Asp Asp Glu Glu Glu Thr Thr Ala Ser Thr Leu Arg Gly Lys
   1               5                  10                  15    
 Pro Asn Arg Arg Pro Ser Arg Arg Ser Arg Thr Ser Ala Asn Ala Gly
              20                  25                  30        
 Ala Leu Asp Gly Gly Gly Met Glu Asp Asp Glu Glu Glu Thr Thr Ala
          35                  40                  45            
 Ser Thr Leu Arg Gly Lys Pro Arg Pro Pro Pro Val Ser Ala Gln Ser
      50                  55                  60                
 Ala Phe Ser Tyr Ile Pro Pro Arg Arg Leu Asp Pro Lys Glu His Ser
  65                  70                  75                  80
 Tyr Tyr Tyr Arg Pro Ala Arg Thr Gly Ile Ile Ser Leu Tyr Asp Cys
                  85                  90                  95    
 Ile Phe Lys Arg Arg Leu Asp Tyr Asp Gln Lys Leu His Arg Asp Asp
             100                 105                 110        
 Arg Glu His Ala Lys Ser Leu Gly Leu His Val Asn Glu Glu Glu Gln
         115                 120                 125            
 Glu Arg Pro Val Gly Val Leu Thr Ser Ser Val Tyr Gly Lys Arg Ile
     130                 135                 140                
 Asn Gln Pro Ile Glu Pro Leu Asn Arg Asp Phe Gly Arg Ala Asn His
 145                 150                 155                 160
 Val Gln Ala Asp Phe Tyr Arg Lys Asn Asp Ile Pro Ser Leu Lys Glu
                 165                 170                 175    
 Pro Gly Phe Gly His Ile Ala Pro Ser
             180                 185



      <210> 649
      <211> 913
      <212> PRT
      <213> Homo sapiens


      <400> 649
 Met His Phe Glu Asn Ile Ser Ser Pro Glu Ser Ser Pro Glu Ile Lys
   1               5                  10                  15    
 Arg Arg Thr Tyr Ser Gln Glu Gly Tyr Asp Arg Ser Ser Thr Met Leu
              20                  25                  30        
 Thr Leu Gly Pro Phe Arg Asn Ser Asn Leu Thr Glu Leu Gly Leu Gln
          35                  40                  45            
 Glu Ile Lys Thr Ile Gly Tyr Thr Ser Pro Arg Ser Arg Thr Glu Val
      50                  55                  60                
 Asn Arg Gln Cys Pro Gly Glu Lys Glu Pro Val Ser Asp Leu Gln Leu
  65                  70                  75                  80
 Gly Leu Asp Ala Val Glu Pro Thr Ala Leu His Lys Thr Leu Glu Thr
                  85                  90                  95    
 Pro Ala His Asp Arg Ala Glu Pro Asn Ser Gln Leu Asp Ser Thr His
             100                 105                 110        
 Ser Gly Arg Gly Thr Met Tyr Ser Ser Trp Val Lys Ser Pro Asp Arg
         115                 120                 125            
 Thr Gly Val Asn Phe Ser Val Asn Ser Asn Leu Arg Asp Leu Thr Pro
     130                 135                 140                
 Ser His Gln Leu Glu Val Gly Gly Gly Phe Arg Ile Ser Glu Ser Lys
 145                 150                 155                 160
 Cys Leu Met Gln Asp Asp Thr Arg Gly Met Phe Met Glu Thr Thr Val
                 165                 170                 175    
 Phe Cys Thr Ser Glu Asp Gly Leu Val Ser Gly Phe Gly Arg Thr Val
             180                 185                 190        
 Asn Asp Asn Leu Ile Asp Gly Asn Cys Thr Pro Gln Asn Pro Pro Gln
         195                 200                 205            
 Lys Lys Lys Val Ser Leu Leu Glu Tyr Arg Lys Arg Gln Arg Glu Ala
     210                 215                 220                
 Arg Lys Ser Gly Ser Lys Thr Glu Asn Phe Pro Leu Ile Ser Val Ser
 225                 230                 235                 240
 Pro His Ala Ser Gly Ser Leu Ser Asn Asn Gly Asp Gly Cys Ala Ser
                 245                 250                 255    
 Ser Asn Asp Asn Gly Glu Gln Val Asp His Thr Ala Ser Leu Pro Leu
             260                 265                 270        
 Pro Thr Pro Ala Thr Val Tyr Asn Ala Thr Ser Glu Glu Thr Ser Asn
         275                 280                 285            
 Asn Cys Pro Val Lys Asp Ala Thr Ala Ser Glu Lys Asn Glu Pro Glu
     290                 295                 300                
 Val Gln Trp Thr Ala Ser Thr Ser Val Glu Gln Val Arg Glu Arg Ser
 305                 310                 315                 320
 Tyr Gln Arg Ala Leu Leu Leu Ser Asp His Arg Lys Asp Lys Asp Ser
                 325                 330                 335    
 Gly Gly Glu Ser Pro Cys Val Ser Cys Ser Pro Ser His Val Gln Ser
             340                 345                 350        
 Ser Pro Ser Ser His Ser Asn His Ile Pro Gln Leu Gln Ala Lys Gly
         355                 360                 365            
 Pro Val Pro Ser Phe Ser Glu Leu Met Glu Asp Pro Asp Pro Glu Asn
     370                 375                 380                
 Pro Glu Pro Thr Thr Thr Asn Glu Cys Pro Ser Pro Asp Thr Ser Gln
 385                 390                 395                 400
 Asn Thr Cys Lys Ser Pro Pro Lys Met Ser Lys Pro Gly Ser Pro Gly
                 405                 410                 415    
 Ser Val Ile Pro Ala Gln Ala His Gly Lys Ile Phe Thr Lys Pro Asp
             420                 425                 430        
 Pro Gln Trp Asp Ser Thr Val Ser Ala Ser Glu Ala Glu Asn Gly Val
         435                 440                 445            
 His Leu Lys Thr Glu Leu Gln Gln Lys Gln Leu Ser Asn Asn Asn Gln
     450                 455                 460                
 Ala Leu Ser Lys Asn His Pro Pro Gln Thr His Val Arg Asn Ser Ser
 465                 470                 475                 480
 Glu Gln Leu Ser Gln Lys Leu Pro Ser Val Pro Thr Lys Leu His Cys
                 485                 490                 495    
 Pro Pro Ser Pro His Leu Glu Asn Pro Pro Lys Ser Ser Thr Pro His
             500                 505                 510        
 Thr Pro Val Gln His Gly Tyr Leu Ser Pro Lys Pro Pro Ser Gln Gln
         515                 520                 525            
 Leu Gly Ser Pro Tyr Arg Pro His His Ser Gln Ser Pro Gln Val Gly
     530                 535                 540                
 Thr Pro Gln Arg Glu Pro Gln Arg Asn Phe Tyr Pro Ala Ala Gln Asn
 545                 550                 555                 560
 Leu Pro Ala Asn Thr Gln Gln Ala Thr Ser Gly Thr Leu Phe Thr Gln
                 565                 570                 575    
 Thr Pro Ser Gly Gln Ser Ser Ala Thr Tyr Ser Gln Phe Asn Gln Gln
             580                 585                 590        
 Ser Leu Asn Ser Thr Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Ser
         595                 600                 605            
 Ser Ser Tyr Tyr Gln Asn Gln Gln Pro Ser Ala Asn Phe Gln Asn Tyr
     610                 615                 620                
 Asn Gln Leu Lys Gly Ser Leu Ser Gln Gln Thr Val Phe Thr Ser Gly
 625                 630                 635                 640
 Pro Asn Gln Ala Leu Pro Gly Thr Thr Ser Gln Gln Thr Val Pro Gly
                 645                 650                 655    
 His His Val Thr Pro Gly His Phe Leu Pro Ser Gln Asn Pro Thr Ile
             660                 665                 670        
 His His Gln Thr Ala Ala Ala Val Val Pro Pro Pro Pro Pro Pro Pro
         675                 680                 685            
 Pro Ala Pro Gly Pro His Leu Val Gln Gln Pro Asn Ser His Gln Gln
     690                 695                 700                
 His Ser Val Ala His Val Val Gly Pro Val His Ala Val Thr Pro Gly
 705                 710                 715                 720
 Ser His Ile His Ser Gln Thr Ala Gly His His Leu Pro Pro Pro Pro
                 725                 730                 735    
 Pro Pro Pro Gly Pro Ala Pro His His His Pro Pro Pro His Pro Ser
             740                 745                 750        
 Thr Gly Leu Gln Gly Leu Gln Ala Gln His Gln His Val Val Asn Ser
         755                 760                 765            
 Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Ser Ser Val Leu Ala Ser
     770                 775                 780                
 Gly His His Thr Thr Ser Ala Gln Ala Leu His His Pro Pro His Gln
 785                 790                 795                 800
 Gly Pro Pro Leu Phe Pro Ser Ser Ala His Pro Thr Val Pro Pro Tyr
                 805                 810                 815    
 Pro Ser Gln Ala Thr His His Thr Thr Leu Gly Pro Gly Pro Gln His
             820                 825                 830        
 Gln Pro Ser Gly Thr Gly Pro His Cys Pro Leu Pro Val Thr Gly Pro
         835                 840                 845            
 His Leu Gln Pro Gln Gly Pro Asn Ser Ile Pro Thr Pro Thr Ala Ser
     850                 855                 860                
 Gly Phe Cys Pro His Pro Gly Ser Val Ala Leu Pro His Gly Val Gln
 865                 870                 875                 880
 Gly Pro Gln Gln Ala Ser Pro Val Pro Gly Gln Ile Pro Ile His Arg
                 885                 890                 895    
 Ala Gln Val Pro Pro Thr Phe Gln Asn Asn Tyr His Gly Ser Gly Trp
             900                 905                 910        
 His
    



      <210> 650
      <211> 78
      <212> PRT
      <213> Homo sapiens


      <400> 650
 Met Ser Glu Val Leu Pro Tyr Gly Asp Glu Lys Leu Ser Pro Tyr Gly
   1               5                  10                  15    
 Asp Gly Gly Asp Val Gly Gln Ile Phe Ser Cys Arg Leu Gln Asp Thr
              20                  25                  30        
 Asn Asn Phe Phe Gly Ala Gly Gln Asn Lys Arg Pro Pro Lys Leu Gly
          35                  40                  45            
 Gln Ile Gly Arg Ser Lys Arg Val Val Ile Glu Asp Asp Arg Ile Asp
      50                  55                  60                
 Asp Val Leu Lys Asn Met Thr Asp Lys Ala Pro Pro Gly Val
  65                  70                  75            



      <210> 651
      <211> 165
      <212> PRT
      <213> Homo sapiens


      <400> 651
 Met Thr Cys Lys Met Ser Gln Leu Glu Arg Asn Ile Glu Thr Ile Ile
   1               5                  10                  15    
 Asn Thr Phe His Gln Tyr Ser Val Lys Leu Gly His Pro Asp Thr Leu
              20                  25                  30        
 Asn Gln Gly Glu Phe Lys Glu Leu Val Arg Lys Asp Leu Gln Asn Phe
          35                  40                  45            
 Leu Lys Lys Glu Asn Lys Asn Glu Lys Val Ile Glu His Ile Met Glu
      50                  55                  60                
 Asp Leu Asp Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile
  65                  70                  75                  80
 Met Leu Met Ala Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu
                  85                  90                  95    
 Gly Asp Glu Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly
             100                 105                 110        
 Thr Pro Leu Arg Pro Gln Trp Pro Arg Ser Gln Trp Pro Arg Pro Arg
         115                 120                 125            
 Pro Gln Ser Trp Trp Pro Arg Pro Gln Pro Leu Ile Arg Arg Pro Gly
     130                 135                 140                
 His Pro Ala Ser Thr Gln Pro Gly Pro Arg Gly Leu Leu Cys Gln Thr
 145                 150                 155                 160
 Ala Trp Leu Trp Gly
                 165



      <210> 652
      <211> 171
      <212> PRT
      <213> Homo sapiens


      <400> 652
 Met Thr Cys Lys Met Ser Gln Leu Glu Arg Asn Ile Glu Thr Ile Ile
   1               5                  10                  15    
 Asn Thr Phe His Gln Tyr Ser Val Lys Leu Gly His Pro Asp Thr Leu
              20                  25                  30        
 Asn Gln Gly Glu Phe Lys Glu Leu Val Arg Lys Asp Leu Gln Asn Phe
          35                  40                  45            
 Leu Lys Lys Glu Asn Lys Asn Glu Lys Val Ile Glu His Ile Met Glu
      50                  55                  60                
 Asp Leu Asp Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile
  65                  70                  75                  80
 Met Leu Met Ala Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu
                  85                  90                  95    
 Gly Asp Glu Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly
             100                 105                 110        
 Thr Pro Leu Arg Pro Gln Trp Pro Arg Ser Gln Trp Pro Arg Pro Arg
         115                 120                 125            
 Pro Gln Ser Trp Trp Pro Arg Pro Gln Pro Leu Ile Arg Arg Pro Gly
     130                 135                 140                
 His Pro Ala Ser Thr Gln Pro Gly Pro Arg Gly Leu Leu Cys Gln Thr
 145                 150                 155                 160
 Val Leu Ala Val Gly Leu Gly Ala Gly Ala Lys
                 165                 170    



      <210> 653
      <211> 138
      <212> PRT
      <213> Homo sapiens


      <400> 653
 Met Thr Cys Lys Met Ser Gln Leu Glu Arg Asn Ile Glu Thr Ile Ile
   1               5                  10                  15    
 Asn Thr Phe His Gln Tyr Ser Val Lys Leu Gly His Pro Asp Thr Leu
              20                  25                  30        
 Asn Gln Gly Glu Phe Lys Glu Leu Val Arg Lys Asp Leu Gln Asn Phe
          35                  40                  45            
 Leu Lys Lys Glu Asn Lys Asn Glu Lys Val Ile Glu His Ile Met Glu
      50                  55                  60                
 Asp Leu Asp Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile
  65                  70                  75                  80
 Met Leu Met Ala Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu
                  85                  90                  95    
 Gly Asp Glu Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly
             100                 105                 110        
 Thr Pro Leu Arg Pro Gln Trp Pro Arg Ser Gln Trp Pro Arg His Gly
         115                 120                 125            
 His Ser His Gly Gly His Gly His Ser His
     130                 135            



      <210> 654
      <211> 166
      <212> PRT
      <213> Homo sapiens


      <400> 654
 Met Leu Arg Arg Pro Arg Gly Arg Ala Gly Cys Gly Arg Pro Gly Pro
   1               5                  10                  15    
 Gly Pro Thr Gly Arg His Val Gly Pro Gln Ala Cys Gly Ala Glu Arg
              20                  25                  30        
 Ala Phe Gly Ser Trp Glu Glu His Pro Ala Glu Glu Ala Ala Pro Gly
          35                  40                  45            
 Ala Gln Arg His Leu Trp Leu Gln Arg Val Pro Tyr His Glu Glu Pro
      50                  55                  60                
 Glu Ala Arg Arg Gly Glu Arg Gln Arg Leu Leu Leu Cys Asn Gln Glu
  65                  70                  75                  80
 Val Met Gln Arg Asp Ile Ala Ala Gly Asp Phe Ile Glu His Ala Glu
                  85                  90                  95    
 Phe Ser Gly Asn Leu Tyr Gly Thr Ser Lys Val Ala Val Gln Ala Val
             100                 105                 110        
 Gln Ala Met Asn Arg Ile Cys Val Leu Asp Val Asp Leu Gln Gly Val
         115                 120                 125            
 Arg Asn Ile Lys Ala Thr Asp Leu Arg Pro Ser Thr Ser Leu Cys Ser
     130                 135                 140                
 Arg Leu His Cys Thr Cys Trp Ser Ser Gly Cys Gly Ser Ala Thr Leu
 145                 150                 155                 160
 Lys Pro Arg Arg Ala Trp
                 165    



      <210> 655
      <211> 183
      <212> PRT
      <213> Homo sapiens


      <400> 655
 Met Val Val Gln Val Val Pro Gln Gly Cys Gly Ile Ile Arg Tyr Asp
   1               5                  10                  15    
 Ala Ser Gly Ser His Ala Glu Gly Cys Phe Lys Ile Arg Leu Phe Trp
              20                  25                  30        
 Ser Pro Gln Thr Gln Arg Glu Pro Thr Met Val Leu Ser Pro Ala Asp
          35                  40                  45            
 Lys Thr Asn Val Lys Ala Ala Trp Gly Lys Val Gly Ala His Ala Gly
      50                  55                  60                
 Glu Tyr Gly Ala Glu Ala Leu Glu Arg Met Phe Leu Ser Phe Pro Thr
  65                  70                  75                  80
 Thr Lys Thr Tyr Phe Pro His Phe Asp Leu Ser His Gly Ser Ala Gln
                  85                  90                  95    
 Val Lys Gly His Gly Lys Lys Val Ala Asp Ala Leu Thr Asn Ala Val
             100                 105                 110        
 Ala His Val Asp Asp Met Pro Asn Ala Leu Ser Ala Leu Ser Asp Leu
         115                 120                 125            
 His Ala His Lys Leu Arg Val Asp Pro Val Asn Phe Lys Leu Leu Ser
     130                 135                 140                
 His Cys Leu Leu Val Thr Leu Ala Ala His Leu Pro Ala Glu Phe Thr
 145                 150                 155                 160
 Pro Ala Val His Ala Ser Leu Asp Lys Phe Leu Ala Ser Val Ser Thr
                 165                 170                 175    
 Val Leu Thr Ser Lys Tyr Arg
             180            



      <210> 656
      <211> 298
      <212> PRT
      <213> Homo sapiens


      <400> 656
 Met Gly Phe Val Lys Val Val Lys Asn Lys Ala Tyr Phe Lys Arg Tyr
   1               5                  10                  15    
 Gln Val Lys Phe Arg Arg Arg Gln Glu Gly Lys Thr Gly Tyr Tyr Ala
              20                  25                  30        
 Arg Lys Tyr Leu Glu Ile Gln Asp Lys Asn Lys Tyr Asn Thr Pro Lys
          35                  40                  45            
 Tyr Arg Ile Val Val His Leu Thr Asn Arg Asp Ile Ile Ser Gln Ile
      50                  55                  60                
 Ala Tyr Ala Arg Ile Glu Gly Asp Met Ile Val Cys Ala Ala Tyr Ala
  65                  70                  75                  80
 His Glu Leu Pro Lys Tyr Gly Val Lys Val Gly Leu Thr Asn Tyr Ala
                  85                  90                  95    
 Ala Ala Tyr Cys Thr Gly Leu Leu Leu Ala Arg Arg Leu Leu Asn Arg
             100                 105                 110        
 Phe Gly Met Asp Lys Ile Tyr Glu Gly Gln Val Glu Val Thr Gly Asp
         115                 120                 125            
 Glu Tyr Asn Val Glu Ser Ile Asp Gly Gln Pro Gly Ala Phe Thr Cys
     130                 135                 140                
 Tyr Leu Asp Ala Gly Leu Ala Arg Thr Thr Thr Gly Asn Lys Val Phe
 145                 150                 155                 160
 Gly Ala Leu Lys Gly Ala Val Asp Gly Gly Leu Ser Ile Pro His Ser
                 165                 170                 175    
 Thr Lys Arg Phe Pro Gly Tyr Asp Ser Glu Ser Lys Glu Phe Asn Ala
             180                 185                 190        
 Glu Val His Arg Lys His Ile Met Gly Gln Asn Val Ala Asp Tyr Met
         195                 200                 205            
 Arg Tyr Leu Met Glu Glu Asp Glu Asp Ala Tyr Lys Lys Gln Phe Ser
     210                 215                 220                
 Gln Tyr Ile Lys Asn Ser Val Thr Pro Asp Met Met Glu Glu Met Tyr
 225                 230                 235                 240
 Lys Lys Gly Ser Cys Trp Leu Tyr Glu Arg Ile Gln Ser Met Lys Lys
                 245                 250                 255    
 Lys Pro Lys Lys Glu Val Lys Lys Lys Arg Trp Asn Arg Pro Lys Met
             260                 265                 270        
 Ser Leu Ala Gln Lys Lys Asp Arg Val Ala Gln Lys Lys Ala Ser Phe
         275                 280                 285            
 Leu Arg Ala Pro Arg Ser Gly Cys Glu Ser
     290                 295            



      <210> 657
      <211> 303
      <212> PRT
      <213> Homo sapiens


      <400> 657
 Met Gln Leu Thr Ser His Gly Ala Glu Thr Leu Thr Arg Gly His Lys
   1               5                  10                  15    
 Leu Lys Pro Asn Val Gln Cys Trp Val Gly Ser Pro Leu Ser Arg Asp
              20                  25                  30        
 Ala Leu Gln Gly Ile Gly Ala Ala Ser Gln Leu Ser Val Cys Arg Leu
          35                  40                  45            
 Arg Gly Phe Lys Gln Gln Arg Leu Ser Gln Pro Ser Cys Ala Glu Asp
      50                  55                  60                
 Asp Phe Ser Thr Glu Ala Glu Ser Trp Pro Pro Pro Leu Pro Arg Leu
  65                  70                  75                  80
 Pro Ala Pro Ala Ala Val Pro Pro Ser Ser Arg Phe Pro Arg Phe Pro
                  85                  90                  95    
 Gly Ala Leu Gly Cys Pro Gln Leu Ser Pro Ser Pro Arg Asn Ala Arg
             100                 105                 110        
 Pro Gly Pro Ala Gly Asp Thr Arg Gly His Ala Arg Ser Thr Ala Arg
         115                 120                 125            
 Pro Pro Asp His Gly Arg Leu Ala Thr Arg Lys His Ser Pro Pro Asn
     130                 135                 140                
 Cys Asp Glu Ala Pro Arg Arg Arg Pro Pro His Ser Arg Arg Thr Arg
 145                 150                 155                 160
 Asp Pro Glu Ile Arg Pro Pro Met Gly Ser His Ser Pro Glu Ser Tyr
                 165                 170                 175    
 Leu Ser Arg Met Ala Pro Ala Lys Asn Ser Gly Lys Lys Lys Met Asp
             180                 185                 190        
 His Ser Ala Ile Asn Glu Val Met Thr Gln Glu Tyr Thr Asn Ile His
         195                 200                 205            
 Lys His Ile His Arg Val Gly Phe Lys Lys Arg Ala Pro Gln Ala Leu
     210                 215                 220                
 Lys Glu Ile Gln Lys Phe Ala Met Lys Glu Met Gly Thr Pro Asp Val
 225                 230                 235                 240
 Arg Ile Asp Thr Arg Leu Asn Lys Ala Val Trp Ala Lys Gly Ile Arg
                 245                 250                 255    
 Asn Ile Pro Tyr Arg Ile Arg Val Gln Leu Ser Arg Glu Tyr Asn Glu
             260                 265                 270        
 Asp Glu Asp Ser Pro Asn Lys Leu Cys Thr Ser Val Thr Tyr Val Pro
         275                 280                 285            
 Val Thr Thr Phe Lys Asn Leu Gln Thr Val Asn Val Asp Glu Asn
     290                 295                 300            



      <210> 658
      <211> 86
      <212> PRT
      <213> Homo sapiens


      <400> 658
 Met Phe Arg Arg Pro Val Leu Gln Val Leu Arg Gln Phe Val Arg His
   1               5                  10                  15    
 Glu Ser Glu Thr Thr Thr Ser Leu Val Leu Glu Arg Cys Asp Val Ser
              20                  25                  30        
 Gln Lys Thr Thr Trp His Arg Ile Ser Val Phe Arg Pro Gly Leu Arg
          35                  40                  45            
 Asp Val Ala Tyr Gln Tyr Val Lys Lys Gly Ser Arg Ile Tyr Leu Glu
      50                  55                  60                
 Gly Lys Ile Asp Tyr Gly Glu Tyr Met Asp Met Ser Asp Gln Thr Lys
  65                  70                  75                  80
 Glu Lys Glu Leu Lys Gly
                  85    



      <210> 659
      <211> 374
      <212> PRT
      <213> Homo sapiens


      <400> 659
 Met Leu Asn Ile Ser Glu Ser Cys Arg Ser Pro Glu Glu Arg Met Lys
   1               5                  10                  15    
 Glu Phe Ile Gly Ile Val Trp Asn Ala Val Lys His Leu Thr Leu Gln
              20                  25                  30        
 Leu Glu Val Gln Ser Cys Cys Val Phe Ile Pro Asn Asp Ser Leu Pro
          35                  40                  45            
 Ser Pro Ser Thr Ile Val Ser Gly Asp Ile Pro Gly Thr Val Arg Ser
      50                  55                  60                
 Trp Tyr His Gly Gln Thr Ser Met Pro Gly Thr Leu Val Leu Cys Leu
  65                  70                  75                  80
 Pro Gln Ile Lys Ile Ile Ser Ala Gly His Lys Tyr Met Glu Pro Leu
                  85                  90                  95    
 Gln Glu Ile Pro Phe Val Ile Pro Arg Pro Ile Leu Glu Glu Gly Asp
             100                 105                 110        
 Ala Phe Pro Trp Thr Ile Ser Leu His Asn Phe Ser Ile Tyr Thr Leu
         115                 120                 125            
 Leu Gly Lys Gln Val Thr Leu Cys Leu Val Glu Pro Met Gly Cys Thr
     130                 135                 140                
 Ser Thr Leu Ala Val Thr Ser Gln Lys Leu Leu Ala Thr Gly Pro Asp
 145                 150                 155                 160
 Thr Arg His Ser Phe Val Val Cys Leu His Val Asp Leu Glu Ser Leu
                 165                 170                 175    
 Glu Ile Lys Cys Ser Asn Pro Gln Val Gln Leu Phe Tyr Glu Leu Thr
             180                 185                 190        
 Asp Ile Met Asn Lys Val Trp Asn Lys Ile Gln Lys Arg Gly Asn Leu
         195                 200                 205            
 Asn Leu Ser Pro Thr Ser Pro Glu Thr Met Ala Gly Pro Val Pro Thr
     210                 215                 220                
 Ser Pro Val Arg Ser Ser Ile Gly Thr Ala Pro Pro Asp Thr Ser Thr
 225                 230                 235                 240
 Cys Ser Pro Ser Ala Asp Ile Gly Thr Thr Thr Glu Gly Asp Ser Ile
                 245                 250                 255    
 Gln Ala Gly Glu Glu Ser Pro Phe Ser Asp Ser Val Thr Leu Glu Gln
             260                 265                 270        
 Thr Thr Ser Asn Ile Gly Gly Thr Ser Gly Arg Val Ser Leu Trp Met
         275                 280                 285            
 Gln Trp Val Leu Pro Lys Ile Thr Ile Lys Leu Phe Ala Pro Asp Pro
     290                 295                 300                
 Glu Asn Lys Gly Thr Glu Val Cys Met Val Ser Glu Leu Glu Asp Leu
 305                 310                 315                 320
 Ser Ala Ser Ile Asp Val Gln Asp Val Tyr Thr Lys Val Lys Cys Lys
                 325                 330                 335    
 Ile Glu Ser Phe Asn Ile Asp His Tyr Arg Ser Arg Pro Gly Glu Gly
             340                 345                 350        
 Trp Gln Ser Gly His Phe Glu Gly Val Phe Leu Gln Cys Lys Glu Lys
         355                 360                 365            
 Ser Val Val Arg Pro Ile
     370                



      <210> 660
      <211> 406
      <212> PRT
      <213> Homo sapiens


      <400> 660
 Met Ala Asp Ser Gln Leu Phe Cys Val Ala Glu Glu Arg Ser Gly His
   1               5                  10                  15    
 Cys Ala Val Val Asp Gly Asn Phe Leu Tyr Val Trp Gly Gly Tyr Val
              20                  25                  30        
 Ser Ile Glu Asp Asn Glu Val Tyr Leu Pro Asn Asp Glu Ile Trp Thr
          35                  40                  45            
 Tyr Asp Ile Asp Ser Gly Leu Trp Arg Met His Leu Met Glu Gly Glu
      50                  55                  60                
 Leu Pro Ala Ser Met Ser Gly Ser Cys Gly Ala Cys Ile Asn Gly Lys
  65                  70                  75                  80
 Leu Tyr Ile Phe Gly Gly Tyr Asp Asp Lys Gly Tyr Ser Asn Arg Leu
                  85                  90                  95    
 Tyr Phe Val Asn Leu Arg Thr Arg Asp Glu Thr Tyr Ile Trp Glu Lys
             100                 105                 110        
 Ile Thr Asp Phe Glu Gly Gln Pro Pro Thr Pro Arg Asp Lys Leu Ser
         115                 120                 125            
 Cys Trp Val Tyr Lys Asp Arg Leu Ile Tyr Phe Gly Gly Tyr Gly Cys
     130                 135                 140                
 Arg Arg His Ser Glu Leu Gln Asp Cys Phe Asp Val His Asp Ala Ser
 145                 150                 155                 160
 Trp Glu Glu Gln Ile Phe Trp Gly Trp His Asn Asp Val His Ile Phe
                 165                 170                 175    
 Asp Thr Lys Thr Gln Thr Trp Phe Gln Pro Glu Ile Lys Gly Gly Val
             180                 185                 190        
 Pro Pro Gln Pro Arg Ala Ala His Thr Cys Ala Val Leu Gly Asn Lys
         195                 200                 205            
 Gly Tyr Ile Phe Gly Gly Arg Val Leu Gln Thr Arg Met Asn Asp Leu
     210                 215                 220                
 His Tyr Leu Asn Leu Asp Thr Trp Thr Trp Ser Gly Arg Ile Thr Ile
 225                 230                 235                 240
 Asn Gly Glu Ser Pro Lys His Arg Ser Trp His Thr Leu Thr Pro Ile
                 245                 250                 255    
 Ala Asp Asp Lys Leu Phe Leu Cys Gly Gly Leu Ser Ala Asp Asn Ile
             260                 265                 270        
 Pro Leu Ser Asp Gly Trp Ile His Asn Val Thr Thr Asn Cys Trp Lys
         275                 280                 285            
 Gln Leu Thr His Leu Pro Lys Thr Arg Pro Arg Leu Trp His Thr Ala
     290                 295                 300                
 Cys Leu Gly Lys Glu Asn Glu Ile Met Val Phe Gly Gly Ser Lys Asp
 305                 310                 315                 320
 Asp Leu Leu Ala Leu Asp Thr Gly His Cys Asn Asp Leu Leu Ile Phe
                 325                 330                 335    
 Gln Thr Gln Pro Tyr Ser Leu Leu Arg Ser Cys Leu Asp Cys Ile Gly
             340                 345                 350        
 Lys Asn Ser Ile Met Leu Glu Ser Gln Ile Ser Leu Leu Pro Pro Lys
         355                 360                 365            
 Leu Leu Gln Gln Val Leu Lys Lys Ile Thr Phe Trp Ala Ala Ala Asn
     370                 375                 380                
 His Arg Glu Glu Gln Arg Val Gln Lys Glu Glu Thr Glu Asn Lys Tyr
 385                 390                 395                 400
 Gln Trp Ile Ser Ser Asn
                 405    



      <210> 661
      <211> 113
      <212> PRT
      <213> Homo sapiens


      <400> 661
 Met Thr Glu Asn Gly Ser His Gln Leu Ile Val Lys Ala Arg Phe Asn
   1               5                  10                  15    
 Phe Lys Gln Thr Asn Glu Asp Glu Leu Ser Val Cys Lys Gly Asp Ile
              20                  25                  30        
 Ile Tyr Val Thr Arg Val Glu Glu Gly Gly Trp Trp Glu Gly Thr Leu
          35                  40                  45            
 Asn Gly Arg Thr Gly Trp Phe Pro Ser Asn Tyr Val Arg Glu Ile Lys
      50                  55                  60                
 Ser Ser Glu Arg Pro Leu Ser Pro Lys Ala Val Lys Gly Phe Glu Thr
  65                  70                  75                  80
 Ala Pro Leu Thr Lys Asn Tyr Tyr Thr Val Cys Tyr Arg Thr Ser Trp
                  85                  90                  95    
 Thr Leu Lys Lys Asn Met Leu Lys Asn Phe Ser Leu Phe Leu Leu Leu
             100                 105                 110        
 Thr
    



      <210> 662
      <211> 239
      <212> PRT
      <213> Homo sapiens


      <400> 662
 Met Gly Ser Thr Ser Val Pro Leu Ser Ser Pro Leu Lys Glu Leu Gln
   1               5                  10                  15    
 Gly Phe His Arg Phe Thr Gly Val Val Ala Asp Gly Asn Phe Arg Phe
              20                  25                  30        
 Leu Val Arg Ile Phe Trp Tyr Cys Trp Leu Asp Pro Phe Pro Met Gln
          35                  40                  45            
 Ser Leu Met Gln Ala Pro Leu Leu Ile Ala Leu Gly Leu Leu Leu Ala
      50                  55                  60                
 Ala Pro Ala Gln Ala His Leu Lys Lys Pro Ser Gln Leu Ser Ser Phe
  65                  70                  75                  80
 Ser Trp Asp Asn Cys Asp Glu Gly Lys Asp Pro Ala Val Ile Arg Ser
                  85                  90                  95    
 Leu Thr Leu Glu Pro Asp Pro Ile Val Val Pro Gly Asn Val Thr Leu
             100                 105                 110        
 Ser Val Val Gly Ser Thr Ser Val Pro Leu Ser Ser Pro Leu Lys Val
         115                 120                 125            
 Asp Leu Val Leu Glu Lys Glu Val Ala Gly Leu Trp Ile Lys Ile Pro
     130                 135                 140                
 Cys Thr Asp Tyr Ile Gly Ser Cys Thr Phe Glu His Phe Cys Asp Val
 145                 150                 155                 160
 Leu Asp Met Leu Ile Pro Thr Gly Glu Pro Cys Pro Glu Pro Leu Arg
                 165                 170                 175    
 Thr Tyr Gly Leu Pro Cys His Cys Pro Phe Lys Glu Gly Thr Tyr Ser
             180                 185                 190        
 Leu Pro Lys Ser Glu Phe Val Val Pro Asp Leu Glu Leu Pro Ser Trp
         195                 200                 205            
 Leu Thr Thr Gly Asn Tyr Arg Ile Glu Ser Val Leu Ser Ser Ser Gly
     210                 215                 220                
 Lys Arg Leu Gly Cys Ile Lys Ile Ala Ala Ser Leu Lys Gly Ile
 225                 230                 235                



      <210> 663
      <211> 322
      <212> PRT
      <213> Homo sapiens


      <400> 663
 Met Ser Trp Val Glu Ala Ala Gly Val Ser Ser Thr Ala Leu Glu Asp
   1               5                  10                  15    
 Arg Ile Val Ala Lys His Glu Glu Val Pro Glu Val Ser Val Gln Tyr
              20                  25                  30        
 Glu Glu Lys Phe Gln Asn His His Lys Leu Pro Ser Gln Leu Ser Ser
          35                  40                  45            
 Phe Ser Trp Asp Asn Cys Asp Glu Gly Lys Asp Pro Ala Val Ile Arg
      50                  55                  60                
 Ser Leu Thr Leu Glu Pro Asp Pro Ile Ile Val Pro Gly Asn Val Thr
  65                  70                  75                  80
 Leu Ser Val Met Gly Ser Thr Ser Val Pro Leu Ser Ser Pro Leu Lys
                  85                  90                  95    
 Glu Leu Gln Gly Phe His Arg Phe Thr Gly Val Val Ala Asp Gly Asn
             100                 105                 110        
 Phe Arg Phe Leu Val Arg Ile Phe Trp Tyr Cys Trp Leu Asp Pro Phe
         115                 120                 125            
 Pro Met Gln Ser Leu Met Gln Ala Pro Leu Leu Ile Ala Leu Gly Leu
     130                 135                 140                
 Leu Leu Ala Ala Pro Ala Gln Ala His Leu Lys Lys Pro Ser Gln Leu
 145                 150                 155                 160
 Ser Ser Phe Ser Trp Asp Asn Cys Asp Glu Gly Lys Asp Pro Ala Val
                 165                 170                 175    
 Ile Arg Ser Leu Thr Leu Glu Pro Asp Pro Ile Val Val Pro Gly Asn
             180                 185                 190        
 Val Thr Leu Ser Val Val Gly Ser Thr Ser Val Pro Leu Ser Ser Pro
         195                 200                 205            
 Leu Lys Val Asp Leu Val Leu Glu Lys Glu Val Ala Gly Leu Trp Ile
     210                 215                 220                
 Lys Ile Pro Cys Thr Asp Tyr Ile Gly Ser Cys Thr Phe Glu His Phe
 225                 230                 235                 240
 Cys Asp Val Leu Asp Met Leu Ile Pro Thr Gly Glu Pro Cys Pro Glu
                 245                 250                 255    
 Pro Leu Arg Thr Tyr Gly Leu Pro Cys His Cys Pro Phe Lys Glu Gly
             260                 265                 270        
 Thr Tyr Ser Leu Pro Lys Ser Glu Phe Val Val Pro Asp Leu Glu Leu
         275                 280                 285            
 Pro Ser Trp Leu Thr Thr Gly Asn Tyr Arg Ile Glu Ser Val Leu Ser
     290                 295                 300                
 Ser Ser Gly Lys Arg Leu Gly Cys Ile Lys Ile Ala Ala Ser Leu Lys
 305                 310                 315                 320
 Gly Ile
        



      <210> 664
      <211> 85
      <212> PRT
      <213> Homo sapiens


      <400> 664
 Met Ala His Tyr Lys Ala Ala Asn Leu Lys Arg Glu Gln Phe Arg Arg
   1               5                  10                  15    
 Tyr Leu Glu Lys Ser Gly Val Leu Asp Thr Leu Thr Lys Val Leu His
              20                  25                  30        
 His Leu Gly Thr Ala Thr Pro Glu Asn Pro Glu Ile Glu Leu Leu Cys
          35                  40                  45            
 Leu Glu Leu Ala Lys Thr Lys Glu Lys Tyr Lys Ala Ile Val Glu Lys
      50                  55                  60                
 Asn Lys Lys Leu Lys Ala Lys Leu Ala Gln Tyr Glu Pro Pro Gln Glu
  65                  70                  75                  80
 Glu Lys Tyr Ala Glu
                  85



      <210> 665
      <211> 251
      <212> PRT
      <213> Homo sapiens


      <400> 665
 Met Ala Arg Arg Ala Asp Ser Pro Leu Ala Ser Cys His Gln Leu Ile
   1               5                  10                  15    
 Gly Pro Thr Gly Thr Ile Leu Thr Lys Ile Ile Arg Tyr Leu Leu Leu
              20                  25                  30        
 Glu Gly Leu Lys Leu Arg Glu Glu Pro Lys Met Asp Ser Ser Pro Asp
          35                  40                  45            
 Ala Lys Glu Ile Arg Gly Asp Ala Ala Arg Ser Val Thr Ser Ser Val
      50                  55                  60                
 Phe Val Lys Ala Ala Leu Ile Lys Gly Arg Glu Gln Glu Thr His Glu
  65                  70                  75                  80
 Gln Ile Asn Tyr Asn Met Lys Asp Lys Cys Lys Tyr Arg Glu Phe Phe
                  85                  90                  95    
 Gly Arg Gly Ser Arg Ile Gly Thr Gly Glu Ala Glu Asp Pro Ser Pro
             100                 105                 110        
 Thr Leu Ser Lys Ala Val Lys Arg Phe Ser Met Ala Leu Asn Leu Leu
         115                 120                 125            
 Ser Gly Ser Arg Asp Ala Leu Leu Lys Glu Lys Asn Lys Thr Lys Gln
     130                 135                 140                
 Asp Lys Thr Lys Pro Asn Gln Tyr Leu Asp Lys Lys Gln Ala Ser Tyr
 145                 150                 155                 160
 Ala Ala Val Ala Val Thr Met Ala His Tyr Lys Ala Ala Asn Leu Lys
                 165                 170                 175    
 Arg Glu Gln Phe Arg Arg Tyr Leu Glu Lys Ser Gly Val Leu Asp Thr
             180                 185                 190        
 Leu Thr Lys Val Leu His His Leu Gly Thr Ala Thr Pro Glu Asn Pro
         195                 200                 205            
 Glu Ile Glu Leu Leu Cys Leu Glu Leu Ala Lys Thr Lys Glu Lys Tyr
     210                 215                 220                
 Lys Ala Ile Val Glu Lys Asn Lys Lys Leu Lys Ala Lys Leu Ala Gln
 225                 230                 235                 240
 Tyr Glu Pro Pro Gln Glu Glu Lys Tyr Ala Glu
                 245                 250    



      <210> 666
      <211> 138
      <212> PRT
      <213> Homo sapiens


      <400> 666
 Met Ala Val Arg Gly Pro Leu His Ser Gln Gln Ser Arg Gly Glu Asp
   1               5                  10                  15    
 Gly Ser Ala Cys Thr Gln Leu Ser Ala Ser Pro Ala Arg Gln Pro Arg
              20                  25                  30        
 Arg Pro Gln Gln Gln Arg Pro Glu Glu Pro Pro Gln Pro Arg Asn Gly
          35                  40                  45            
 Gln Gly Lys Thr Phe Val Asn Ile Thr Pro Ala Lys Val Gly Val Leu
      50                  55                  60                
 Val Gly Lys Asp Trp Ser Ser Phe Phe Val Asn Arg Leu Thr Leu Arg
  65                  70                  75                  80
 Gly Gln Lys Cys Thr Val Val Leu Asp Ser Leu Leu Gln Asp Gly Glu
                  85                  90                  95    
 Leu Thr Val His Leu Gln Thr Lys Ser Ile Gly Gly Ala Pro Thr Phe
             100                 105                 110        
 Asn Val Thr Ile Thr Met Thr Ala Lys Thr Leu Gly Leu Leu Met Gly
         115                 120                 125            
 Lys Gly Val His Gly Ser Phe Thr Ile Ser
     130                 135            



      <210> 667
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 667
 Met Val His Ser Ala Tyr Leu Gly Asp Thr Ile Glu Gln Val Cys Thr
   1               5                  10                  15    
 Lys Lys Gln Ala Gly Thr Gly Pro Glu Phe Pro Gly Tyr Arg Arg Pro
              20                  25                  30        
 Thr Arg Pro Pro Thr Arg Pro Gln Ile Pro Ser Val Ala Ala Lys Met
          35                  40                  45            
 Met Cys Gly Ala Pro Ser Ala Thr Gln Pro Ala Thr Ala Glu Thr Gln
      50                  55                  60                
 His Ile Ala Asp Gln Val Arg Ser Gln Leu Glu Glu Lys Glu Asn Lys
  65                  70                  75                  80
 Lys Phe Pro Val Phe Lys Ala Val Ser Phe Lys Ser Gln Val Val Ala
                  85                  90                  95    
 Gly Thr Asn Tyr Phe Ile Lys Val His Val Gly Asp Glu Asp Phe Val
             100                 105                 110        
 His Leu Arg Val Phe Gln Ser Leu Pro His Glu Asn Lys Pro Leu Thr
         115                 120                 125            
 Leu Ser Asn Tyr Gln Thr Asn Lys Ala Lys His Asp Glu Leu Thr Tyr
     130                 135                 140                
 Phe
 145



      <210> 668
      <211> 817
      <212> PRT
      <213> Homo sapiens


      <400> 668
 Met Arg Pro Pro Arg Ala Pro Val Val Pro Pro Asp Leu Gly Gly Pro
   1               5                  10                  15    
 Arg Leu Cys Pro Val Pro Ala Ala Gly Gly Ala Arg Ser Pro Ser Ser
              20                  25                  30        
 Pro Tyr Ser Val Glu Thr Pro Tyr Gly Phe His Leu Asp Leu Asp Phe
          35                  40                  45            
 Leu Lys Tyr Ile Glu Glu Leu Glu Arg Gly Pro Ala Ala Arg Arg Ala
      50                  55                  60                
 Pro Gly Pro Pro Thr Ser Arg Arg Pro Arg Ala Pro Arg Pro Gly Leu
  65                  70                  75                  80
 Ala Gly Ala Arg Ser Pro Gly Ala Trp Thr Ser Ser Glu Ser Leu Ala
                  85                  90                  95    
 Ser Asp Asp Gly Gly Ala Pro Gly Ile Leu Ser Gln Gly Ala Pro Ser
             100                 105                 110        
 Gly Leu Leu Met Gln Pro Leu Ser Pro Arg Ala Pro Val Arg Asn Pro
         115                 120                 125            
 Arg Val Glu His Thr Leu Arg Glu Thr Ser Arg Arg Leu Glu Leu Ala
     130                 135                 140                
 Gln Thr His Glu Arg Ala Pro Ser Pro Gly Arg Gly Val Pro Arg Ser
 145                 150                 155                 160
 Pro Arg Gly Ser Gly Arg Ser Ser Pro Ala Pro Asn Leu Ala Pro Ala
                 165                 170                 175    
 Ser Pro Gly Pro Ala Gln Leu Gln Leu Val Arg Glu Gln Met Ala Ala
             180                 185                 190        
 Ala Leu Arg Arg Leu Arg Glu Leu Glu Asp Gln Ala Arg Thr Leu Pro
         195                 200                 205            
 Glu Leu Gln Glu Gln Val Arg Ala Leu Arg Ala Glu Lys Ala Arg Leu
     210                 215                 220                
 Leu Ala Gly Arg Ala Gln Pro Glu Pro Asp Gly Glu Ala Glu Thr Arg
 225                 230                 235                 240
 Pro Asp Lys Leu Ala Gln Leu Arg Arg Leu Thr Glu Arg Leu Ala Thr
                 245                 250                 255    
 Ser Glu Arg Gly Gly Arg Ala Arg Ala Ser Pro Arg Ala Asp Ser Pro
             260                 265                 270        
 Asp Gly Leu Ala Ala Gly Arg Ser Glu Gly Ala Leu Gln Val Leu Asp
         275                 280                 285            
 Gly Glu Val Gly Ser Leu Asp Gly Thr Pro Gln Thr Arg Glu Val Ala
     290                 295                 300                
 Ala Glu Ala Val Pro Glu Thr Arg Glu Ala Gly Ala Gln Ala Val Pro
 305                 310                 315                 320
 Glu Thr Arg Glu Ala Gly Val Glu Ala Ala Pro Glu Thr Val Glu Ala
                 325                 330                 335    
 Asp Ala Trp Val Thr Glu Ala Leu Leu Gly Leu Pro Ala Ala Ala Glu
             340                 345                 350        
 Arg Glu Leu Glu Leu Leu Arg Ala Ser Leu Glu His Gln Arg Gly Val
         355                 360                 365            
 Ser Glu Leu Leu Arg Gly Arg Leu Arg Glu Leu Glu Glu Ala Arg Glu
     370                 375                 380                
 Ala Ala Glu Glu Ala Ala Ala Gly Ala Arg Ala Gln Leu Arg Glu Ala
 385                 390                 395                 400
 Thr Thr Gln Thr Pro Trp Ser Cys Ala Glu Lys Ala Ala Gln Thr Glu
                 405                 410                 415    
 Ser Pro Ala Glu Ala Pro Ser Leu Thr Gln Glu Ser Ser Pro Gly Ser
             420                 425                 430        
 Met Asp Gly Asp Arg Ala Val Ala Pro Ala Gly Ile Leu Lys Ser Ile
         435                 440                 445            
 Met Lys Lys Arg Asp Gly Thr Pro Gly Ala Gln Pro Ser Ser Gly Pro
     450                 455                 460                
 Lys Ser Leu Gln Phe Val Gly Val Leu Asn Gly Glu Tyr Glu Ser Ser
 465                 470                 475                 480
 Ser Ser Glu Asp Ala Ser Asp Ser Glu Asn Gly Gly Ala Glu Pro Pro
                 485                 490                 495    
 Gly Ser Ser Ser Gly Ser Gly Asp Asp Ser Gly Gly Gly Ser Asp Ser
             500                 505                 510        
 Gly Thr Pro Gly Pro Pro Ser Gly Gly Asp Ile Arg Asp Pro Glu Pro
         515                 520                 525            
 Glu Ala Glu Ala Glu Pro Gln Gln Val Ala Gln Gly Arg Cys Glu Leu
     530                 535                 540                
 Ser Pro Arg Leu Arg Glu Ala Cys Val Ala Leu Gln Arg Gln Leu Ser
 545                 550                 555                 560
 Arg Pro Arg Gly Val Ala Ser Asp Gly Gly Ala Val Arg Leu Val Ala
                 565                 570                 575    
 Gln Glu Trp Phe Arg Val Ser Ser Gln Arg Arg Ser Gln Ala Glu Pro
             580                 585                 590        
 Val Ala Arg Met Leu Glu Gly Val Arg Arg Leu Gly Pro Glu Leu Leu
         595                 600                 605            
 Ala His Val Val Asn Leu Ala Asp Gly Asn Gly Asn Thr Ala Leu His
     610                 615                 620                
 Tyr Ser Val Ser His Gly Asn Leu Ala Ile Ala Ser Leu Leu Leu Asp
 625                 630                 635                 640
 Thr Gly Ala Cys Glu Val Asn Arg Gln Asn Arg Ala Gly Tyr Ser Ala
                 645                 650                 655    
 Leu Met Leu Ala Ala Leu Thr Ser Val Arg Gln Glu Glu Glu Asp Met
             660                 665                 670        
 Ala Val Val Gln Arg Leu Phe Cys Met Gly Asp Val Asn Ala Lys Ala
         675                 680                 685            
 Ser Gln Thr Gly Gln Thr Ala Leu Met Leu Ala Ile Ser His Gly Arg
     690                 695                 700                
 Gln Asp Met Val Ala Thr Leu Leu Ala Cys Gly Ala Asp Val Asn Ala
 705                 710                 715                 720
 Gln Asp Ala Asp Gly Ala Thr Ala Leu Met Cys Ala Ser Glu Tyr Gly
                 725                 730                 735    
 Arg Leu Asp Thr Val Arg Leu Leu Leu Thr Gln Pro Gly Cys Asp Pro
             740                 745                 750        
 Ala Ile Leu Asp Asn Glu Gly Thr Ser Ala Leu Ala Ile Ala Leu Glu
         755                 760                 765            
 Ala Glu Gln Asp Glu Val Ala Ala Leu Leu His Ala His Leu Ser Ser
     770                 775                 780                
 Gly Gln Pro Asp Thr Gln Ser Glu Ser Pro Pro Gly Ser Gln Thr Ala
 785                 790                 795                 800
 Thr Pro Gly Glu Gly Glu Cys Gly Asp Asn Gly Glu Asn Pro Gln Val
                 805                 810                 815    
 Gln
    



      <210> 669
      <211> 417
      <212> PRT
      <213> Homo sapiens


      <400> 669
 Met Ser Gly Arg Ser Arg Gly Arg Lys Ser Ser Arg Ala Lys Asn Arg
   1               5                  10                  15    
 Gly Lys Gly Arg Ala Lys Ala Arg Val Arg Pro Ala Pro Asp Asp Ala
              20                  25                  30        
 Pro Arg Asp Pro Asp Pro Ser Gln Tyr Gln Ser Leu Gly Glu Asp Thr
          35                  40                  45            
 Gln Ala Ala Gln Val Gln Ala Gly Ala Gly Trp Gly Gly Leu Glu Ala
      50                  55                  60                
 Ala Ala Ser Ala Gln Leu Leu Arg Leu Gly Glu Glu Ala Ala Cys Arg
  65                  70                  75                  80
 Leu Pro Leu Asp Cys Gly Leu Ala Leu Arg Ala Arg Ala Ala Gly Asp
                  85                  90                  95    
 His Gly Gln Ala Ala Ala Arg Pro Gly Pro Gly Lys Ala Ala Ser Leu
             100                 105                 110        
 Ser Glu Arg Leu Ala Ala Asp Ser Val Phe Val Gly Thr Ala Gly Thr
         115                 120                 125            
 Val Gly Arg Pro Lys Asn Ala Pro Arg Val Gly Asn Arg Arg Gly Pro
     130                 135                 140                
 Ala Gly Lys Lys Ala Pro Glu Thr Cys Ser Thr Ala Gly Arg Gly Pro
 145                 150                 155                 160
 Gln Val Ile Ala Gly Gly Arg Gln Lys Lys Gly Ala Ala Gly Glu Asn
                 165                 170                 175    
 Thr Ser Val Ser Ala Gly Glu Glu Lys Lys Glu Glu Arg Asp Ala Gly
             180                 185                 190        
 Ser Gly Pro Pro Ala Thr Glu Gly Ser Met Asp Thr Leu Glu Asn Val
         195                 200                 205            
 Gln Leu Lys Leu Glu Asn Met Asn Ala Gln Ala Asp Arg Ala Tyr Leu
     210                 215                 220                
 Arg Leu Ser Arg Lys Phe Gly Gln Leu Arg Leu Gln His Leu Glu Arg
 225                 230                 235                 240
 Arg Asn His Leu Ile Gln Asn Ile Pro Gly Phe Trp Gly Gln Ala Phe
                 245                 250                 255    
 Gln Asn His Pro Gln Leu Ala Ser Phe Leu Asn Ser Gln Glu Lys Glu
             260                 265                 270        
 Val Leu Ser Tyr Leu Asn Ser Leu Glu Val Glu Glu Leu Gly Leu Ala
         275                 280                 285            
 Arg Leu Gly Tyr Lys Ile Lys Phe Tyr Phe Asp Arg Asn Pro Tyr Phe
     290                 295                 300                
 Gln Asn Lys Val Leu Ile Lys Glu Tyr Gly Cys Gly Pro Ser Gly Gln
 305                 310                 315                 320
 Val Val Ser Arg Ser Thr Pro Ile Gln Trp Leu Pro Gly His Asp Leu
                 325                 330                 335    
 Gln Ser Leu Ser Gln Gly Asn Pro Glu Asn Asn Arg Ser Phe Phe Gly
             340                 345                 350        
 Trp Phe Ser Asn His Ser Ser Ile Glu Ser Asp Lys Ile Val Glu Ile
         355                 360                 365            
 Ile Asn Glu Glu Leu Trp Pro Asn Pro Leu Gln Phe Tyr Leu Leu Ser
     370                 375                 380                
 Glu Gly Ala Arg Val Glu Lys Gly Lys Glu Lys Glu Gly Arg Gln Gly
 385                 390                 395                 400
 Pro Gly Lys Gln Pro Met Glu Thr Thr Gln Pro Gly Val Ser Gln Ser
                 405                 410                 415    
 Asn
    



      <210> 670
      <211> 283
      <212> PRT
      <213> Homo sapiens


      <400> 670
 Met Asn Leu Asn Gly Arg Trp Gln Gly Val Ile Ser Gly Cys Phe Gln
   1               5                  10                  15    
 Gly Leu Ser Ser Val Met Ala Leu Gly Leu Lys Cys Phe Arg Met Val
              20                  25                  30        
 His Pro Thr Phe Arg Asn Tyr Leu Ala Ala Ser Ile Arg Pro Val Ser
          35                  40                  45            
 Glu Val Thr Leu Lys Thr Val His Glu Arg Gln His Gly His Arg Gln
      50                  55                  60                
 Tyr Met Ala Tyr Ser Ala Val Pro Val Arg His Phe Ala Thr Lys Lys
  65                  70                  75                  80
 Ala Lys Ala Lys Gly Lys Gly Gln Ser Gln Thr Arg Val Asn Ile Asn
                  85                  90                  95    
 Ala Ala Leu Val Glu Asp Ile Ile Asn Leu Glu Glu Val Asn Glu Glu
             100                 105                 110        
 Met Lys Ser Val Ile Glu Ala Leu Lys Asp Asn Phe Asn Lys Thr Leu
         115                 120                 125            
 Asn Ile Arg Thr Ser Pro Gly Ser Leu Asp Lys Ile Ala Val Val Thr
     130                 135                 140                
 Ala Asp Gly Lys Leu Ala Leu Asn Gln Ile Ser Gln Ile Ser Met Lys
 145                 150                 155                 160
 Ser Pro Gln Leu Ile Leu Val Asn Met Ala Ser Phe Pro Glu Cys Thr
                 165                 170                 175    
 Ala Ala Ala Ile Lys Ala Ile Arg Glu Ser Gly Met Asn Leu Asn Pro
             180                 185                 190        
 Glu Val Glu Gly Thr Leu Ile Arg Val Pro Ile Pro Gln Val Thr Arg
         195                 200                 205            
 Glu His Arg Glu Met Leu Val Lys Leu Ala Lys Gln Asn Thr Asn Lys
     210                 215                 220                
 Ala Lys Asp Ser Leu Arg Lys Val Arg Thr Asn Ser Met Asn Lys Leu
 225                 230                 235                 240
 Lys Lys Ser Lys Asp Thr Val Ser Glu Asp Thr Ile Arg Leu Ile Glu
                 245                 250                 255    
 Lys Gln Ile Ser Gln Met Ala Asp Asp Thr Val Ala Glu Leu Asp Arg
             260                 265                 270        
 His Leu Ala Val Lys Thr Lys Glu Leu Leu Gly
         275                 280            



      <210> 671
      <211> 279
      <212> PRT
      <213> Homo sapiens


      <400> 671
 Met Ala Ala Ser Arg Asn Gly Phe Glu Ala Val Glu Ala Glu Gly Ser
   1               5                  10                  15    
 Ala Gly Cys Arg Gly Ser Ser Gly Met Glu Val Val Leu Pro Leu Asp
              20                  25                  30        
 Pro Ala Val Pro Ala Pro Leu Cys Pro His Gly Pro Thr Leu Leu Phe
          35                  40                  45            
 Val Lys Val Thr Gln Gly Lys Glu Glu Thr Arg Arg Phe Tyr Ala Cys
      50                  55                  60                
 Ser Ala Cys Arg Asp Arg Lys Asp Cys Asn Phe Phe Gln Trp Glu Asp
  65                  70                  75                  80
 Glu Lys Leu Ser Gly Ala Arg Leu Ala Ala Arg Glu Ala His Asn Arg
                  85                  90                  95    
 Arg Cys Gln Pro Pro Leu Ser Arg Thr Gln Cys Val Glu Arg Tyr Leu
             100                 105                 110        
 Lys Phe Ile Glu Leu Pro Leu Thr Gln Arg Lys Phe Cys Gln Thr Cys
         115                 120                 125            
 Gln Gln Leu Leu Leu Pro Asp Asp Trp Gly Gln His Ser Glu His Gln
     130                 135                 140                
 Val Leu Gly Asn Val Ser Ile Thr Gln Leu Arg Arg Pro Ser Gln Leu
 145                 150                 155                 160
 Leu Tyr Pro Leu Glu Asn Lys Lys Thr Asn Ala Gln Tyr Leu Phe Ala
                 165                 170                 175    
 Asp Arg Ser Cys Gln Phe Leu Val Asp Leu Leu Ser Ala Leu Gly Phe
             180                 185                 190        
 Arg Arg Val Leu Cys Val Gly Thr Pro Arg Leu His Glu Leu Ile Lys
         195                 200                 205            
 Leu Thr Ala Ser Gly Asp Lys Lys Ser Asn Ile Lys Ser Leu Leu Leu
     210                 215                 220                
 Asp Ile Asp Phe Arg Tyr Ser Gln Phe Tyr Met Glu Asp Ser Phe Cys
 225                 230                 235                 240
 His Tyr Asn Met Phe Asn His His Phe Phe Asp Gly Lys Val Arg Ala
                 245                 250                 255    
 Val Thr Ile Ile Ser Leu Phe Ser Tyr Cys Gly Ile Thr Asp Phe Arg
             260                 265                 270        
 Val Pro Pro Leu Phe Phe Phe
         275                



      <210> 672
      <211> 487
      <212> PRT
      <213> Homo sapiens


      <400> 672
 Met Leu Tyr Lys Lys Gln Ala Gly Thr Gly Pro Glu Phe Pro Gly Ser
   1               5                  10                  15    
 Val Lys Gln Ala Gly Cys Ser Ala Ala Pro Gly Ala Val Pro Pro Pro
              20                  25                  30        
 Glu Ala Asp Ser Thr Ser Ala Gly Met Ser Arg Arg Pro Cys Ser Cys
          35                  40                  45            
 Ala Leu Arg Pro Pro Arg Cys Ser Cys Ser Ala Ser Pro Ser Ala Val
      50                  55                  60                
 Thr Ala Ala Gly Arg Pro Arg Pro Ser Asp Ser Cys Lys Glu Glu Ser
  65                  70                  75                  80
 Ser Thr Leu Ser Val Lys Met Lys Cys Asp Phe Asn Cys Asn His Val
                  85                  90                  95    
 His Ser Gly Leu Lys Leu Val Lys Pro Asp Asp Ile Gly Arg Leu Val
             100                 105                 110        
 Ser Tyr Thr Pro Ala Tyr Leu Glu Gly Ser Cys Lys Asp Cys Ile Lys
         115                 120                 125            
 Asp Tyr Glu Arg Leu Ser Cys Ile Gly Ser Pro Ile Val Ser Pro Arg
     130                 135                 140                
 Ile Val Glu Leu Glu Thr Glu Ser Lys Arg Leu His Asn Lys Glu Asn
 145                 150                 155                 160
 Gln His Val Gln Gln Thr Leu Asn Ser Thr Asn Glu Ile Glu Ala Leu
                 165                 170                 175    
 Glu Thr Ser Arg Leu Tyr Glu Asp Ser Gly Tyr Ser Ser Phe Ser Leu
             180                 185                 190        
 Gln Ser Gly Leu Ser Glu His Glu Glu Gly Ser Leu Leu Glu Glu Asn
         195                 200                 205            
 Phe Gly Asp Ser Leu Gln Ser Cys Leu Leu Gln Ile Gln Ser Pro Asp
     210                 215                 220                
 Gln Tyr Pro Asn Lys Asn Leu Leu Pro Val Leu His Phe Glu Lys Val
 225                 230                 235                 240
 Val Cys Ser Thr Leu Lys Lys Asn Ala Lys Arg Asn Pro Lys Val Asp
                 245                 250                 255    
 Arg Glu Met Leu Lys Glu Ile Ile Ala Arg Gly Asn Phe Arg Leu Gln
             260                 265                 270        
 Asn Ile Ile Gly Arg Lys Met Gly Leu Glu Cys Val Asp Ile Leu Ser
         275                 280                 285            
 Glu Leu Phe Arg Arg Gly Leu Arg His Val Leu Ala Thr Ile Leu Ala
     290                 295                 300                
 Gln Leu Ser Asp Met Asp Leu Ile Asn Val Ser Lys Val Ser Thr Thr
 305                 310                 315                 320
 Trp Lys Lys Ile Leu Glu Asp Asp Lys Gly Ala Phe Gln Leu Tyr Ser
                 325                 330                 335    
 Lys Ala Ile Gln Arg Val Thr Glu Asn Asn Asn Lys Phe Ser Pro His
             340                 345                 350        
 Ala Ser Thr Arg Glu Tyr Val Met Phe Arg Thr Pro Leu Ala Ser Val
         355                 360                 365            
 Gln Lys Ser Ala Ala Gln Thr Ser Leu Lys Lys Asp Ala Gln Thr Lys
     370                 375                 380                
 Leu Ser Asn Gln Gly Asp Gln Lys Gly Ser Thr Tyr Ser Arg His Asn
 385                 390                 395                 400
 Glu Phe Ser Glu Val Ala Lys Thr Leu Lys Lys Asn Glu Ser Leu Lys
                 405                 410                 415    
 Ala Cys Ile Arg Cys Asn Ser Pro Ala Lys Tyr Asp Cys Tyr Leu Gln
             420                 425                 430        
 Arg Ala Thr Cys Lys Arg Glu Gly Cys Gly Phe Asp Tyr Cys Thr Lys
         435                 440                 445            
 Cys Leu Cys Asn Tyr His Thr Thr Lys Asp Cys Ser Asp Gly Lys Leu
     450                 455                 460                
 Leu Lys Ala Ser Cys Lys Ile Gly Pro Leu Pro Gly Thr Lys Lys Ser
 465                 470                 475                 480
 Lys Lys Asn Leu Arg Arg Leu
                 485        



      <210> 673
      <211> 236
      <212> PRT
      <213> Homo sapiens


      <400> 673
 Met Leu Ser Arg Val Thr Ser Gly Arg Ala Arg Arg Ala Thr Ala Ile
   1               5                  10                  15    
 Arg Leu Val Asn Cys Leu Glu Arg Pro Asn Leu Phe Leu Leu Gln Leu
              20                  25                  30        
 Ile Ala Pro Leu Ala Arg Leu Thr Thr Tyr Leu Asn Ser Ile Thr Glu
          35                  40                  45            
 Arg Gly Ala Leu Asp Glu Pro Leu Ala Arg Arg Phe Phe Ala Gln Val
      50                  55                  60                
 Leu Ala Ala Val Arg His Cys His Ser Cys Gly Val Val His Arg Asp
  65                  70                  75                  80
 Ile Lys Asp Glu Asn Leu Leu Val Asp Leu Arg Ser Gly Glu Leu Lys
                  85                  90                  95    
 Leu Ile Asp Phe Gly Ser Gly Ala Leu Leu Lys Asp Thr Val Tyr Thr
             100                 105                 110        
 Asp Phe Asp Gly Thr Arg Val Tyr Ser Pro Pro Glu Trp Ile Arg Tyr
         115                 120                 125            
 His Arg Tyr His Gly Arg Ser Ala Thr Val Trp Ser Leu Gly Val Leu
     130                 135                 140                
 Leu Tyr Asp Met Val Cys Gly Asp Ile Pro Phe Glu Gln Asp Glu Glu
 145                 150                 155                 160
 Ile Leu Arg Gly Arg Leu Leu Phe Arg Arg Arg Val Ser Pro Glu Cys
                 165                 170                 175    
 Gln Gln Leu Ile Arg Trp Cys Leu Ser Leu Arg Pro Ser Glu Arg Pro
             180                 185                 190        
 Ser Leu Asp Gln Ile Ala Ala His Pro Trp Met Leu Gly Ala Asp Gly
         195                 200                 205            
 Gly Ala Pro Glu Ser Cys Asp Leu Arg Leu Cys Thr Leu Asp Pro Asp
     210                 215                 220                
 Asp Val Ala Ser Thr Thr Ser Ser Ser Glu Ser Leu
 225                 230                 235    



      <210> 674
      <211> 403
      <212> PRT
      <213> Homo sapiens


      <400> 674
 Met Glu Thr Leu Ala Ser Cys Thr Ser Glu Leu Ile Ser Glu Glu Met
   1               5                  10                  15    
 Glu Gln Leu Asp Gly Gly Asp Thr Ser Ser Asp Glu Asp Lys Glu Glu
              20                  25                  30        
 His Glu Thr Pro Val Glu Val Glu Leu Met Thr Gln Val Asp Gln Glu
          35                  40                  45            
 Asp Ile Thr Leu Gln Ser Gly Arg Asp Glu Leu Asn Glu Glu Leu Ile
      50                  55                  60                
 Gln Gln Glu Ser Ser Glu Asp Glu Gly Glu Tyr Glu Glu Val Arg Lys
  65                  70                  75                  80
 Asp Gln Asp Ser Val Gly Glu Met Lys Asp Glu Gly Glu Glu Thr Leu
                  85                  90                  95    
 Asn Tyr Pro Asp Thr Thr Ile Asp Leu Ser His Leu Gln Pro Gln Arg
             100                 105                 110        
 Ser Ile Gln Lys Leu Ala Ser Lys Glu Glu Ser Ser Asn Ser Ser Asp
         115                 120                 125            
 Ser Lys Ser Gln Ser Arg Arg His Leu Ser Ala Lys Glu Arg Arg Glu
     130                 135                 140                
 Met Lys Lys Lys Lys Leu Pro Ser Asp Ser Gly Asp Leu Glu Ala Leu
 145                 150                 155                 160
 Glu Gly Lys Asp Lys Glu Lys Glu Ser Thr Val His Ile Glu Thr His
                 165                 170                 175    
 Gln Asn Thr Ser Lys Asn Val Ala Ala Val Gln Pro Met Lys Arg Gly
             180                 185                 190        
 Gln Lys Ser Lys Met Lys Lys Met Lys Glu Lys Tyr Lys Asp Gln Asp
         195                 200                 205            
 Glu Glu Asp Arg Glu Leu Ile Met Lys Leu Leu Gly Ser Ala Gly Ser
     210                 215                 220                
 Asn Lys Glu Glu Lys Gly Lys Lys Gly Lys Lys Gly Lys Thr Lys Asp
 225                 230                 235                 240
 Glu Pro Val Lys Lys Gln Pro Gln Lys Pro Arg Gly Gly Gln Arg Val
                 245                 250                 255    
 Ser Asp Asn Ile Lys Lys Glu Thr Pro Phe Leu Glu Val Ile Thr His
             260                 265                 270        
 Glu Leu Gln Asp Phe Ala Val Asp Asp Pro His Asp Asp Lys Glu Glu
         275                 280                 285            
 Gln Asp Leu Asp Gln Gln Gly Asn Glu Glu Asn Leu Phe Asp Ser Leu
     290                 295                 300                
 Thr Gly Gln Pro His Pro Glu Asp Val Leu Leu Phe Ala Ile Pro Ile
 305                 310                 315                 320
 Cys Ala Pro Tyr Thr Thr Met Thr Asn Tyr Lys Tyr Lys Val Lys Leu
                 325                 330                 335    
 Thr Pro Gly Val Gln Lys Lys Gly Lys Ala Ala Lys Thr Ala Leu Asn
             340                 345                 350        
 Ser Phe Met His Ser Lys Glu Ala Thr Ala Arg Glu Lys Asp Leu Phe
         355                 360                 365            
 Arg Ser Val Lys Asp Thr Asp Leu Ser Arg Asn Ile Pro Gly Lys Val
     370                 375                 380                
 Lys Ser Val Cys Thr Gln Ser Ser Glu Arg Lys Lys Glu Ile Ala Glu
 385                 390                 395                 400
 Met Lys Phe
            



      <210> 675
      <211> 505
      <212> PRT
      <213> Homo sapiens


      <400> 675
 Met Glu Ala Glu Asp Ile Gln Glu Glu Leu Thr Cys Pro Ile Cys Leu
   1               5                  10                  15    
 Asp Tyr Phe Gln Asp Pro Val Ser Ile Glu Cys Gly His Asn Phe Cys
              20                  25                  30        
 Arg Gly Cys Leu His Arg Asn Trp Ala Pro Gly Gly Gly Pro Phe Pro
          35                  40                  45            
 Cys Pro Glu Cys Arg His Pro Ser Ala Pro Ala Ala Leu Arg Pro Asn
      50                  55                  60                
 Trp Ala Leu Ala Arg Leu Thr Glu Lys Thr Gln Arg Arg Arg Leu Gly
  65                  70                  75                  80
 Pro Val Pro Pro Gly Leu Cys Gly Arg His Trp Glu Pro Leu Arg Leu
                  85                  90                  95    
 Phe Cys Glu Asp Asp Gln Arg Pro Val Cys Leu Val Cys Arg Glu Ser
             100                 105                 110        
 Gln Glu His Gln Thr His Ala Met Asp Trp Glu Pro Leu Arg Leu Phe
         115                 120                 125            
 Cys Glu Asp Asp Gln Arg Pro Val Cys Leu Val Cys Arg Glu Ser Gln
     130                 135                 140                
 Glu His Gln Thr His Ala Met Ala Pro Ile Asp Glu Ala Phe Glu Ser
 145                 150                 155                 160
 Tyr Arg Glu Lys Leu Leu Lys Ser Gln Arg Asn Leu Val Ala Lys Met
                 165                 170                 175    
 Lys Lys Val Met His Leu Gln Asp Val Glu Val Lys Asn Ala Thr Gln
             180                 185                 190        
 Trp Lys Asp Lys Ile Lys Ser Gln Arg Met Arg Ile Ser Thr Glu Phe
         195                 200                 205            
 Ser Lys Leu His Asn Phe Leu Val Glu Glu Glu Asp Leu Phe Leu Gln
     210                 215                 220                
 Arg Leu Asn Lys Glu Glu Glu Glu Thr Lys Lys Lys Leu Asn Glu Asn
 225                 230                 235                 240
 Thr Leu Lys Leu Asn Gln Thr Ile Ala Ser Leu Lys Lys Leu Ile Leu
                 245                 250                 255    
 Glu Val Gly Glu Lys Ser Gln Ala Pro Thr Leu Glu Leu Leu Gln Asn
             260                 265                 270        
 Pro Lys Glu Val Leu Thr Arg Ser Glu Ile Gln Asp Val Asn Tyr Ser
         275                 280                 285            
 Leu Glu Ala Val Lys Val Lys Thr Val Cys Gln Ile Pro Leu Met Lys
     290                 295                 300                
 Glu Met Leu Lys Arg Phe Gln Val Ala Val Asn Leu Ala Glu Asp Thr
 305                 310                 315                 320
 Ala His Pro Lys Leu Val Phe Ser Gln Glu Gly Arg Tyr Val Lys Asn
                 325                 330                 335    
 Thr Ala Ser Ala Ser Ser Trp Pro Val Phe Ser Ser Ala Trp Asn Tyr
             340                 345                 350        
 Phe Ala Gly Trp Arg Asn Pro Gln Lys Thr Ala Phe Val Glu Arg Phe
         355                 360                 365            
 Gln His Leu Pro Cys Val Leu Gly Lys Asn Val Phe Thr Ser Gly Lys
     370                 375                 380                
 His Tyr Trp Glu Val Glu Ser Arg Asp Ser Leu Glu Val Ala Val Gly
 385                 390                 395                 400
 Val Cys Arg Glu Asp Val Met Gly Ile Thr Asp Arg Ser Lys Met Ser
                 405                 410                 415    
 Pro Asp Val Gly Ile Trp Ala Ile Tyr Trp Ser Ala Ala Gly Tyr Trp
             420                 425                 430        
 Pro Leu Ile Gly Phe Pro Gly Thr Pro Thr Gln Gln Glu Pro Ala Leu
         435                 440                 445            
 His Arg Val Gly Val Tyr Leu Asp Arg Gly Thr Gly Asn Val Ser Phe
     450                 455                 460                
 Tyr Ser Ala Val Asp Gly Val His Leu His Thr Phe Ser Cys Ser Ser
 465                 470                 475                 480
 Val Ser Arg Leu Arg Pro Phe Phe Trp Leu Ser Pro Leu Ala Ser Leu
                 485                 490                 495    
 Val Ile Pro Pro Val Thr Asp Arg Lys
             500                 505



      <210> 676
      <211> 155
      <212> PRT
      <213> Homo sapiens


      <400> 676
 Met Gly Glu Glu Pro Pro Ser Leu Met Phe Leu Asn Gly Asn Cys Leu
   1               5                  10                  15    
 Glu Thr Leu Lys Lys Lys Glu Pro Glu Gly Gly Arg Arg Arg Leu Ser
              20                  25                  30        
 His Pro Gly Asn Met Gly Trp Met Arg Pro Ser Gln Glu Thr Thr Pro
          35                  40                  45            
 Pro Asp Arg Ser His His Ser Gly Phe Gly Leu Phe Cys Gly Asp Pro
      50                  55                  60                
 Gly Pro Glu Ile Glu Pro Phe Ser Leu Trp Val Phe Pro Gln Glu Met
  65                  70                  75                  80
 Val Leu Glu Ile His Gln Leu Phe Met Asp His Glu Tyr Pro Cys His
                  85                  90                  95    
 His Ile Thr Ser His Cys Thr Trp Val Ala Ala His Trp Thr Thr Ser
             100                 105                 110        
 Gln Ser Cys Ala Ala Trp Gln Gly Cys Arg Arg Ala Cys Cys Ser Thr
         115                 120                 125            
 Trp Trp Lys Ser Pro Ala Gln Cys Thr Arg Pro Thr Val Met Ser Ala
     130                 135                 140                
 Thr Phe Glu Thr Ala Gln Glu Pro Gly Pro Ser
 145                 150                 155



      <210> 677
      <211> 162
      <212> PRT
      <213> Homo sapiens


      <400> 677
 Met Arg Lys Leu Arg Pro Gln Phe Met Asp Ser Glu Ile Cys Ile His
   1               5                  10                  15    
 Asn Ser Phe Ser Ser Ser Gln Lys Val Ile Lys Leu Glu Phe Cys Thr
              20                  25                  30        
 Phe Val Met Ala Ser Ser Phe Gln Ser Asn Thr Val Ile Val Ile His
          35                  40                  45            
 Phe Asn Asn His Gln His Cys Val Arg Cys Pro Leu Phe Lys Tyr Glu
      50                  55                  60                
 Thr Cys Ala Val Ala Trp Leu Leu Pro Gly Gly Lys Asn Leu Val Ile
  65                  70                  75                  80
 Asn Ile Thr Asp Thr Pro Val Thr Thr Asp Ile Trp Arg Ala Tyr Phe
                  85                  90                  95    
 Phe Arg Ile Ile Leu Gln Arg Lys His Phe Gln Thr His Thr Glu Val
             100                 105                 110        
 Gln Val Met Cys Pro His Val Thr Glu Gln Thr Lys Asn Ser Thr Glu
         115                 120                 125            
 Ile Glu Tyr Ser Phe Ser Ile Tyr Gly Gln Glu Asp Gly Val Lys Ile
     130                 135                 140                
 Thr Pro Ser Cys Gly Ser His Pro Cys Tyr Ala Thr Trp Ile Glu Cys
 145                 150                 155                 160
 His Val
        



      <210> 678
      <211> 405
      <212> PRT
      <213> Homo sapiens


      <400> 678
 Met Glu Pro Gly Ala Gly Gly Arg Asn Thr Ala Arg Ala Gln Arg Ala
   1               5                  10                  15    
 Gly Ser Pro Asn Thr Pro Pro Pro Arg Glu Gln Glu Arg Lys Leu Glu
              20                  25                  30        
 Gln Glu Lys Leu Ser Gly Val Val Lys Ser Val His Arg Arg Leu Arg
          35                  40                  45            
 Lys Lys Tyr Arg Glu Val Gly Asp Phe Asp Lys Ile Trp Arg Glu His
      50                  55                  60                
 Cys Glu Asp Glu Glu Thr Leu Cys Glu Tyr Ala Val Ala Met Lys Asn
  65                  70                  75                  80
 Leu Ala Asp Asn His Trp Ala Lys Thr Cys Glu Gly Glu Gly Arg Ile
                  85                  90                  95    
 Glu Trp Cys Cys Ser Val Cys Arg Glu Tyr Phe Gln Asn Gly Gly Lys
             100                 105                 110        
 Arg Lys Ala Leu Glu Lys Asp Glu Lys Arg Ala Val Leu Ala Thr Lys
         115                 120                 125            
 Thr Thr Pro Ala Leu Asn Met His Glu Ser Ser Gln Leu Glu Gly His
     130                 135                 140                
 Leu Thr Asn Leu Ser Phe Thr Asn Pro Glu Phe Ile Leu Ser Leu Leu
 145                 150                 155                 160
 Gln Ala Ser Gly Lys Ile Arg Leu Leu Asp Val Gly Ser Cys Phe Asn
                 165                 170                 175    
 Pro Phe Leu Lys Phe Glu Glu Phe Leu Thr Val Gly Ile Asp Ile Val
             180                 185                 190        
 Pro Ala Val Glu Ser Val Tyr Lys Cys Asp Phe Leu Asn Leu Gln Leu
         195                 200                 205            
 Gln Gln Pro Leu Gln Leu Ala Gln Asp Ala Ile Asp Ala Phe Leu Lys
     210                 215                 220                
 Gln Leu Lys Asn Pro Ile Asp Ser Leu Pro Gly Glu Leu Phe His Val
 225                 230                 235                 240
 Val Val Phe Ser Leu Leu Leu Ser Tyr Phe Pro Ser Pro Tyr Gln Arg
                 245                 250                 255    
 Trp Ile Cys Cys Lys Lys Ala His Glu Leu Leu Val Leu Asn Gly Leu
             260                 265                 270        
 Leu Leu Ile Ile Thr Pro Asp Ser Ser His Gln Asn Arg His Ala Met
         275                 280                 285            
 Met Met Lys Ser Trp Lys Ile Ala Ile Glu Ser Leu Gly Phe Lys Arg
     290                 295                 300                
 Phe Lys Tyr Ser Lys Phe Ser His Met His Leu Met Ala Phe Arg Lys
 305                 310                 315                 320
 Ile Ser Leu Lys Thr Thr Ser Asp Leu Val Ser Arg Asn Tyr Pro Gly
                 325                 330                 335    
 Met Leu Tyr Ile Pro Gln Asp Phe Asn Ser Ile Glu Asp Glu Glu Tyr
             340                 345                 350        
 Ser Asn Pro Ser Cys Tyr Val Arg Ser Asp Ile Glu Asp Glu Gln Leu
         355                 360                 365            
 Ala Tyr Gly Phe Thr Glu Leu Pro Asp Ala Pro Tyr Asp Ser Asp Ser
     370                 375                 380                
 Gly Glu Ser Gln Ala Ser Ser Ile Pro Phe Tyr Glu Leu Glu Asp Pro
 385                 390                 395                 400
 Ile Leu Leu Leu Ser
                 405



      <210> 679
      <211> 309
      <212> PRT
      <213> Homo sapiens


      <400> 679
 Met Ser Asp Leu Gly Ser Glu Glu Leu Glu Glu Glu Gly Glu Asn Asp
   1               5                  10                  15    
 Ile Gly Glu Tyr Glu Gly Gly Arg Asn Glu Ala Gly Glu Arg His Gly
              20                  25                  30        
 Arg Gly Arg Ala Arg Leu Pro Asn Gly Asp Thr Tyr Glu Gly Ser Tyr
          35                  40                  45            
 Glu Phe Gly Lys Arg His Gly Gln Gly Ile Tyr Lys Phe Lys Asn Gly
      50                  55                  60                
 Ala Arg Tyr Ile Gly Glu Tyr Val Arg Asn Lys Lys His Gly Gln Gly
  65                  70                  75                  80
 Thr Phe Ile Tyr Pro Asp Gly Ser Arg Tyr Glu Gly Glu Trp Ala Asn
                  85                  90                  95    
 Asp Leu Arg His Gly His Gly Val Tyr Tyr Tyr Ile Asn Asn Asp Thr
             100                 105                 110        
 Tyr Thr Gly Glu Trp Phe Ala His Gln Arg His Gly Gln Gly Thr Tyr
         115                 120                 125            
 Leu Tyr Ala Glu Thr Gly Ser Lys Tyr Val Gly Thr Trp Val Asn Gly
     130                 135                 140                
 Gln Gln Glu Gly Thr Ala Glu Leu Ile His Leu Asn His Arg Tyr Gln
 145                 150                 155                 160
 Gly Lys Phe Leu Asn Lys Asn Pro Val Gly Pro Gly Lys Tyr Val Phe
                 165                 170                 175    
 Asp Val Gly Cys Glu Gln His Gly Glu Tyr Arg Leu Thr Asp Met Glu
             180                 185                 190        
 Arg Gly Glu Glu Glu Glu Glu Glu Glu Leu Val Thr Val Val Pro Lys
         195                 200                 205            
 Trp Lys Ala Thr Gln Ile Thr Glu Leu Ala Leu Trp Thr Pro Thr Leu
     210                 215                 220                
 Pro Lys Lys Pro Thr Ser Thr Asp Gly Pro Gly Gln Asp Ala Pro Gly
 225                 230                 235                 240
 Ala Glu Ser Ala Gly Glu Pro Gly Glu Glu Ala Gln Ala Leu Leu Glu
                 245                 250                 255    
 Gly Phe Glu Gly Glu Met Asp Met Arg Pro Gly Asp Glu Asp Ala Asp
             260                 265                 270        
 Val Leu Arg Glu Glu Ser Arg Glu Tyr Asp Gln Glu Glu Phe Arg Tyr
         275                 280                 285            
 Asp Met Asp Glu Gly Asn Ile Asn Ser Glu Glu Glu Glu Thr Arg Gln
     290                 295                 300                
 Ser Asp Leu Gln Asp
 305                



      <210> 680
      <211> 343
      <212> PRT
      <213> Homo sapiens


      <400> 680
 Met Ser Asp Leu Gly Ser Glu Glu Leu Glu Glu Glu Gly Glu Asn Asp
   1               5                  10                  15    
 Ile Gly Glu Tyr Glu Gly Gly Arg Asn Glu Ala Gly Glu Arg His Gly
              20                  25                  30        
 Arg Gly Arg Ala Arg Leu Pro Asn Gly Asp Thr Tyr Glu Gly Ser Tyr
          35                  40                  45            
 Glu Phe Gly Lys Arg His Gly Gln Val Gly Ile Glu Glu Phe Glu Arg
      50                  55                  60                
 His Gly Arg Gly Arg Ala Arg Ile Pro Asn Arg Asp Thr Tyr Glu Gly
  65                  70                  75                  80
 Ser Tyr Glu Phe Gly Lys Arg His Gly Gln Gly Ile Tyr Lys Phe Lys
                  85                  90                  95    
 Asn Gly Ala Arg Tyr Ile Gly Glu Tyr Val Arg Asn Lys Lys His Gly
             100                 105                 110        
 Gln Gly Thr Phe Ile Tyr Pro Asp Gly Ser Arg Tyr Glu Gly Glu Trp
         115                 120                 125            
 Ala Asn Asp Leu Arg His Gly His Gly Val Tyr Tyr Tyr Ile Asn Asn
     130                 135                 140                
 Asp Thr Tyr Thr Gly Glu Trp Phe Ala His Gln Arg His Gly Gln Gly
 145                 150                 155                 160
 Thr Tyr Leu Tyr Ala Glu Thr Gly Ser Lys Tyr Val Gly Thr Trp Val
                 165                 170                 175    
 Asn Gly Gln Gln Glu Gly Thr Ala Glu Leu Ile His Leu Asn His Arg
             180                 185                 190        
 Tyr Gln Gly Lys Phe Leu Asn Lys Asn Pro Val Gly Pro Gly Lys Tyr
         195                 200                 205            
 Val Phe Asp Val Gly Cys Glu Gln His Gly Glu Tyr Arg Leu Thr Asp
     210                 215                 220                
 Met Glu Arg Gly Glu Glu Glu Glu Glu Glu Glu Leu Val Thr Val Val
 225                 230                 235                 240
 Pro Lys Trp Lys Ala Thr Gln Ile Thr Glu Leu Ala Leu Trp Thr Pro
                 245                 250                 255    
 Thr Leu Pro Lys Lys Pro Thr Ser Thr Asp Gly Pro Gly Gln Asp Ala
             260                 265                 270        
 Pro Gly Ala Glu Ser Ala Gly Glu Pro Gly Glu Glu Ala Gln Ala Leu
         275                 280                 285            
 Leu Glu Gly Phe Glu Gly Glu Met Asp Met Arg Pro Gly Asp Glu Asp
     290                 295                 300                
 Ala Asp Val Leu Arg Glu Glu Ser Arg Glu Tyr Asp Gln Glu Glu Phe
 305                 310                 315                 320
 Arg Tyr Asp Met Asp Glu Gly Asn Ile Asn Ser Glu Glu Glu Glu Thr
                 325                 330                 335    
 Arg Gln Ser Asp Leu Gln Asp
             340            



      <210> 681
      <211> 176
      <212> PRT
      <213> Homo sapiens


      <400> 681
 Met Thr Glu Asn Val Val Cys Thr Gly Ala Val Asn Ala Val Lys Glu
   1               5                  10                  15    
 Val Trp Glu Lys Arg Ile Lys Lys Leu Asn Glu Asp Leu Lys Arg Glu
              20                  25                  30        
 Lys Glu Phe Gln His Lys Leu Val Arg Ile Trp Glu Glu Arg Val Ser
          35                  40                  45            
 Leu Thr Lys Leu Arg Glu Lys Val Thr Arg Glu Asp Gly Arg Val Ile
      50                  55                  60                
 Leu Lys Ile Glu Lys Glu Glu Trp Lys Thr Leu Pro Ser Ser Leu Leu
  65                  70                  75                  80
 Lys Leu Asn Gln Leu Gln Glu Trp Gln Leu His Arg Thr Gly Leu Leu
                  85                  90                  95    
 Lys Ile Pro Glu Phe Ile Gly Arg Phe Gln Asn Leu Ile Val Leu Asp
             100                 105                 110        
 Leu Ser Arg Asn Thr Ile Ser Glu Ile Pro Pro Gly Ile Gly Leu Leu
         115                 120                 125            
 Thr Arg Leu Gln Glu Leu Ile Leu Ser Tyr Asn Lys Ile Lys Thr Val
     130                 135                 140                
 Pro Lys Glu Leu Ser Asn Cys Ala Ser Leu Glu Lys Leu Glu Leu Ala
 145                 150                 155                 160
 Val Asn Arg Asp Ile Cys Asp Leu Pro Gln Glu Val Gln Glu Phe Trp
                 165                 170                 175    





      <210> 682
      <211> 363
      <212> PRT
      <213> Homo sapiens


      <400> 682
 Met Ala Pro Gly Glu Lys Glu Ser Gly Glu Gly Pro Ala Lys Ser Ala
   1               5                  10                  15    
 Leu Arg Lys Ile Arg Thr Ala Thr Leu Val Ile Ser Leu Ala Arg Gly
              20                  25                  30        
 Trp Gln Gln Trp Ala Asn Glu Asn Ser Ile Arg Gln Ala Gln Glu Pro
          35                  40                  45            
 Thr Gly Trp Leu Pro Gly Gly Thr Gln Asp Ser Pro Gln Ala Pro Lys
      50                  55                  60                
 Pro Ile Thr Pro Pro Thr Ser His Gln Lys Ala Gln Ser Ala Pro Lys
  65                  70                  75                  80
 Ser Pro Pro Arg Leu Pro Glu Gly His Gly Asp Gly Gln Ser Ser Glu
                  85                  90                  95    
 Lys Ala Pro Glu Val Ser His Ile Lys Lys Lys Glu Val Ser Lys Thr
             100                 105                 110        
 Val Val Ser Lys Thr Tyr Glu Arg Gly Gly Asp Lys Leu Glu Arg Val
         115                 120                 125            
 Ala Glu Thr Leu Cys Phe Pro Asp Arg Gly Gly Cys Leu His Glu Glu
     130                 135                 140                
 Glu Lys Tyr Ser Leu Tyr Arg Lys Ile Tyr Gly Val Gly Ser Glu Ser
 145                 150                 155                 160
 Pro Phe Ser Leu Ser Pro Tyr Arg Ser Glu Thr Glu Glu Lys Ile Met
                 165                 170                 175    
 Pro Leu Gly Val Pro Cys Ile Leu Lys Leu Val Ile Gln Val Lys Gly
             180                 185                 190        
 Asn His Gln Glu Met Phe Ser Val Pro Val Phe Ser Val Val Asn Arg
         195                 200                 205            
 Phe Thr Glu Lys Leu Asn Cys Lys Ala Gln Gln Lys Tyr Ser Pro Val
     210                 215                 220                
 Gly Asn Leu Lys Gly Arg Trp Gln Gln Trp Ala Asp Glu His Ile Gln
 225                 230                 235                 240
 Ser Gln Lys Leu Asn Pro Phe Ser Glu Glu Phe Asp Tyr Glu Leu Ala
                 245                 250                 255    
 Met Ser Thr Arg Leu His Lys Gly Asp Glu Gly Tyr Gly Arg Pro Lys
             260                 265                 270        
 Glu Gly Thr Lys Thr Ala Glu Arg Ala Lys Arg Ala Glu Glu His Ile
         275                 280                 285            
 Tyr Arg Glu Met Met Asp Met Cys Phe Ile Ile Cys Thr Met Ala Arg
     290                 295                 300                
 His Arg Arg Asp Gly Lys Ile Gln Val Thr Phe Gly Asp Leu Phe Asp
 305                 310                 315                 320
 Arg Tyr Val Arg Ile Ser Asp Lys Val Val Gly Ile Leu Met Arg Ala
                 325                 330                 335    
 Arg Lys His Gly Leu Val Asp Phe Glu Gly Glu Met Leu Trp Gln Gly
             340                 345                 350        
 Arg Asp Asp His Val Val Ile Thr Leu Leu Lys
         355                 360            



      <210> 683
      <211> 272
      <212> PRT
      <213> Homo sapiens


      <400> 683
 Met Thr Lys Phe Leu Tyr His Arg Arg Thr His Ala Gly Lys Ser Gly
   1               5                  10                  15    
 Ala Pro Pro Thr Gly Ala Thr Ala Pro Pro Ala Pro Ala Glu Pro Thr
              20                  25                  30        
 Pro Pro Pro Pro Pro Pro Ala Pro Pro Ala Gln Leu Pro Cys Pro Gln
          35                  40                  45            
 Cys Ser Lys Ser Phe Ala Ser Ala Ser Arg Leu Ser Arg His Arg Arg
      50                  55                  60                
 Ala Val His Gly Pro Pro Glu Arg Arg His Arg Cys Gly Val Cys Gly
  65                  70                  75                  80
 Lys Gly Phe Lys Lys Leu Ile His Val Arg Asn His Leu Arg Thr His
                  85                  90                  95    
 Thr Gly Glu Arg Pro Phe Gln Cys His Ser Cys Gly Lys Thr Phe Ala
             100                 105                 110        
 Ser Leu Ala Asn Leu Ser Arg His Gln Leu Thr His Thr Gly Ala Arg
         115                 120                 125            
 Pro Tyr Gln Cys Leu Asp Cys Gly Lys Arg Phe Thr Gln Ser Ser Asn
     130                 135                 140                
 Leu Gln Gln His Arg Arg Leu His Leu Arg Pro Val Ala Phe Ala Arg
 145                 150                 155                 160
 Ala Pro Arg Leu Pro Ile Thr Gly Leu Tyr Asn Lys Ser Pro Tyr Tyr
                 165                 170                 175    
 Cys Gly Thr Cys Gly Arg Trp Phe Arg Ala Met Ala Gly Leu Arg Leu
             180                 185                 190        
 His Gln Arg Val His Ala Arg Ala Arg Thr Leu Thr Leu Gln Pro Pro
         195                 200                 205            
 Arg Ser Pro Ser Pro Ala Pro Pro Pro Pro Pro Glu Pro Gln Gln Thr
     210                 215                 220                
 Ile Met Cys Thr Glu Leu Gly Glu Thr Ile Ala Ile Ile Glu Thr Ser
 225                 230                 235                 240
 Gln Pro Leu Ala Leu Glu Asp Thr Leu Gln Leu Cys Gln Ala Ala Leu
                 245                 250                 255    
 Gly Ala Ser Glu Ala Gly Gly Leu Leu Gln Leu Asp Thr Ala Phe Val
             260                 265                 270        





      <210> 684
      <211> 205
      <212> PRT
      <213> Homo sapiens


      <400> 684
 Met Ala Ala Arg Asp Ala Thr Ser Gly Ser Leu Ser Glu Glu Ser Ser
   1               5                  10                  15    
 Ala Leu Asp Leu Pro Ser Val Cys Asp Ile Arg Asp Tyr Val Leu Gln
              20                  25                  30        
 Gly Pro Ser Gln Glu Ala Asn Ser Glu Ala Phe Ser Ser Leu Glu Phe
          35                  40                  45            
 His Ser Phe Pro Tyr Ser Ser Asp Val Asp Pro Asp Thr Ser Asn Leu
      50                  55                  60                
 Asn Ile Glu Gln Asn Asn Ser Trp Thr Ala Glu Asn Phe Trp Leu Asp
  65                  70                  75                  80
 Pro Ala Val Lys Gly Gln Ser Glu Lys Glu Glu Asp Asp Gly Leu Arg
                  85                  90                  95    
 Lys Ser Leu Asp Arg Phe Tyr Glu Met Phe Gly His Pro Gln Pro Gly
             100                 105                 110        
 Ser Ala Asn Ser Leu Ser Ala Ser Val Cys Lys Cys Leu Ser Gln Lys
         115                 120                 125            
 Ile Thr Gln Leu Arg Gly Gln Glu Ser Gln Lys Tyr Ala Leu Arg Ser
     130                 135                 140                
 Phe Gln Met Ala Arg Val Ile Phe Asn Arg Asp Gly Cys Ser Val Leu
 145                 150                 155                 160
 Gln Arg His Ser Arg Asp Thr His Phe Tyr Pro Leu Glu Glu Gly Ser
                 165                 170                 175    
 Thr Ser Leu Asp Asp Glu Lys Pro Asn Pro Gly Leu Ser Lys Asp Ile
             180                 185                 190        
 Thr His Phe Leu Leu Gln Gln Asn Val Met Lys Asp Leu
         195                 200                 205



      <210> 685
      <211> 161
      <212> PRT
      <213> Homo sapiens


      <400> 685
 Met Gly Arg Glu Gly Val Ala Ala Gly Ser Leu Leu Phe Gln Leu Gly
   1               5                  10                  15    
 Ala Leu Pro Pro Pro Trp Gly Gly Lys Thr Ser Ser Ser Ser His Trp
              20                  25                  30        
 Pro Arg Trp Val Pro Lys Pro His Pro Ser Cys Ser Pro Leu Val Thr
          35                  40                  45            
 Ser Ile Tyr Ala His Met Pro Leu Pro Val Leu His Leu His Val Thr
      50                  55                  60                
 Ser Arg Ser Arg Gln Pro Gln Ile Tyr Leu Val Lys Thr Trp Arg Thr
  65                  70                  75                  80
 Arg Ala Glu Ser Lys Arg Asp Val Asn Glu Asn Thr Asp His Arg His
                  85                  90                  95    
 Thr Arg Arg Glu Ala Leu Phe Pro Arg Gly Lys Glu Met Glu Arg Gly
             100                 105                 110        
 Arg Glu Gly Glu Glu Phe Cys Ala Arg Ser Ser Gly Trp Cys Leu Leu
         115                 120                 125            
 Asn Cys Phe Thr His Phe Asn Pro Phe Thr Tyr Pro Gly Arg Asn Pro
     130                 135                 140                
 Gly Leu Ser Pro Phe His Val Gly Leu Phe Ile Gly Leu Leu Ser Glu
 145                 150                 155                 160
 Asn
    



      <210> 686
      <211> 171
      <212> PRT
      <213> Homo sapiens


      <400> 686
 Met Ala Asp Gln Gly Glu Lys Glu Asn Pro Met Gln Lys Leu His Ile
   1               5                  10                  15    
 Cys Lys Leu Cys Leu Asn Ile Cys Val Glu Glu Ser Gly Asp Arg Leu
              20                  25                  30        
 Thr Arg Ala Ala Lys Ala Leu Glu Gln Leu Thr Gly Gln Lys Leu Asp
          35                  40                  45            
 Thr Ile Arg Ser Ser Gly Met Gln Arg Asn Glu Lys Ile Ala Val His
      50                  55                  60                
 Cys Thr Val Gln Gly Ser Lys Ala Glu Glu Ile Leu Glu Lys Asp Leu
  65                  70                  75                  80
 Lys Val Gln Lys Tyr Glu Leu Arg Lys Asn Asn Phe Ser Asp Thr Arg
                  85                  90                  95    
 Asn Phe Gly Phe Gly Ile Gln Glu His Ile Asp Leu Gly Ile Ile Tyr
             100                 105                 110        
 Asp Pro Ser Ile Gly Ile Tyr Gly Leu Asp Phe Tyr Val Val Leu Gly
         115                 120                 125            
 Arg Pro Gly Phe Ser Ile Ala Asp Lys Lys Arg Arg Thr Gly Cys Ile
     130                 135                 140                
 Gly Ala Lys His Arg Ile Ser Lys Glu Asp Ala Met Arg Trp Phe Gln
 145                 150                 155                 160
 Gln Lys Tyr Asp Glu Ile Ile Leu Pro Gly Arg
                 165                 170    



      <210> 687
      <211> 420
      <212> PRT
      <213> Homo sapiens


      <400> 687
 Met Leu Val Leu Glu Gln Phe Leu Ser Ile Leu Pro Lys Glu Thr His
   1               5                  10                  15    
 Asn Trp Val Gln Lys His His Pro Gln Asn Val Lys Gln Ala Leu Val
              20                  25                  30        
 Leu Val Glu Phe Leu Gln Arg Glu Pro Asp Gly Thr Lys Asn Glu Val
          35                  40                  45            
 Thr Ala His Glu Leu Arg Lys Glu Ala Val Leu Leu Gly Gly Thr Ala
      50                  55                  60                
 Val Ala Pro Gly Phe Lys Trp Lys Pro Ala Glu Pro Gln Pro Met Gly
  65                  70                  75                  80
 Val Phe Gln Lys Glu Tyr Trp Asn Thr Tyr Arg Val Leu Gln Glu Gln
                  85                  90                  95    
 Leu Gly Trp Asn Thr His Lys Glu Thr Gln Pro Val Tyr Glu Arg Ala
             100                 105                 110        
 Val His Asp Gln Gln Met Leu Ala Leu Ser Glu Gln Lys Arg Ile Lys
         115                 120                 125            
 His Trp Lys Met Ala Ser Lys Leu Ile Leu Pro Glu Ser Leu Ser Leu
     130                 135                 140                
 Leu Thr Phe Glu Asp Val Ala Val Tyr Phe Ser Glu Glu Glu Trp Gln
 145                 150                 155                 160
 Leu Leu Asn Pro Leu Glu Lys Thr Leu Tyr Asn Asp Val Met Gln Asp
                 165                 170                 175    
 Ile Tyr Glu Thr Val Ile Ser Leu Gly Leu Lys Leu Lys Asn Asp Thr
             180                 185                 190        
 Gly Asn Asp His Pro Ile Ser Val Ser Thr Ser Glu Ile Gln Thr Ser
         195                 200                 205            
 Gly Cys Glu Val Ser Lys Lys Thr Arg Met Lys Ile Ala Gln Lys Thr
     210                 215                 220                
 Met Gly Arg Glu Asn Pro Gly Asp Thr His Ser Val Gln Lys Trp His
 225                 230                 235                 240
 Arg Ala Phe Pro Arg Lys Lys Arg Lys Lys Pro Ala Thr Cys Lys Gln
                 245                 250                 255    
 Glu Leu Pro Lys Leu Met Asp Leu His Gly Lys Gly Pro Thr Gly Glu
             260                 265                 270        
 Lys Pro Phe Lys Cys Gln Glu Cys Gly Lys Ser Phe Arg Val Ser Ser
         275                 280                 285            
 Asp Leu Ile Lys His His Arg Ile His Thr Gly Glu Lys Pro Tyr Lys
     290                 295                 300                
 Cys Gln Gln Cys Asp Arg Arg Phe Arg Trp Ser Ser Asp Leu Asn Lys
 305                 310                 315                 320
 His Phe Met Thr His Gln Gly Ile Lys Pro Tyr Arg Cys Ser Trp Cys
                 325                 330                 335    
 Gly Lys Ser Phe Ser His Asn Thr Asn Leu His Thr His Gln Arg Ile
             340                 345                 350        
 His Thr Gly Glu Lys Pro Phe Lys Cys Asp Glu Cys Gly Lys Arg Phe
         355                 360                 365            
 Ile Gln Asn Ser His Leu Ile Lys His Gln Arg Thr His Thr Gly Glu
     370                 375                 380                
 Gln Pro Tyr Thr Cys Ser Leu Cys Lys Arg Asn Phe Ser Arg Arg Ser
 385                 390                 395                 400
 Ser Leu Leu Arg His Gln Lys Leu His Arg Arg Arg Glu Ala Cys Leu
                 405                 410                 415    
 Val Ser Pro Asn
             420



      <210> 688
      <211> 387
      <212> PRT
      <213> Homo sapiens


      <400> 688
 Met Arg Glu Ile Val Leu Thr Gln Thr Gly Gln Cys Gly Asn Arg Ile
   1               5                  10                  15    
 Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Ala Ile Asp Ser
              20                  25                  30        
 Ala Gly Thr Tyr Arg Gly Asp Arg Asp Leu Leu Leu Lys Arg Ile Asn
          35                  40                  45            
 Val Tyr Tyr Asn Glu Ala Ser Gly Ser Arg Tyr Val Pro Arg Ala Val
      50                  55                  60                
 Leu Thr Asp Leu Glu Pro Gly Thr Leu Asp Ser Val Arg Ser Gly Pro
  65                  70                  75                  80
 Phe Gly Gln Ile Phe Arg Pro Glu Asn Phe Ile Leu Gly Gln Ser Gly
                  85                  90                  95    
 Ala Gly Asn Asn Trp Ala Lys Gly Tyr Tyr Thr Glu Gly Thr Glu Leu
             100                 105                 110        
 Met Glu Ser Val Met Asp Thr Val Arg Arg Glu Ala Glu Ser Cys Asp
         115                 120                 125            
 Cys Leu Gln Gly Phe Gln Leu Ala His Ser Leu Gly Gly Gly Thr Gly
     130                 135                 140                
 Ser Gly Met Gly Thr Leu Leu Leu Ser Lys Ile Gln Glu Glu Tyr Pro
 145                 150                 155                 160
 Asp Arg Ile Ile Asn Thr Phe Ser Val Leu Pro Ser Leu Lys Val Ser
                 165                 170                 175    
 Asp Ala Val Val Glu Pro Tyr Asn Ala Ile Leu Ser Ile His Gln Leu
             180                 185                 190        
 Ile Glu Asn Ala His Glu Thr Phe Cys Ile Asp Asn Glu Ala Leu Arg
         195                 200                 205            
 Leu Asn Ala Asp Leu Arg Lys Leu Ala Met Asn Met Val Pro Phe Pro
     210                 215                 220                
 Trp Leu His Phe Phe Met Pro Ser Phe Ala Pro Leu Thr Ser Gln Gly
 225                 230                 235                 240
 Ser Arg Gln Tyr Gln Ala Leu Thr Val Ala Glu Leu Ile Gln Glu Val
                 245                 250                 255    
 Phe Asp Ala Lys Asn Met Met Ala Ala Cys His Met Ser Met Lys Glu
             260                 265                 270        
 Val Asp Glu Gln Met Leu Asn Leu Gln Lys Asn Ser Ser His Phe Ala
         275                 280                 285            
 His Arg Leu Pro His Asn Val Lys Thr Ala Thr Cys Asp Ile Pro Ser
     290                 295                 300                
 Lys Gly Leu Glu Met Ser Ala Thr Gly Ile Ser Asn Asn Thr Ala Ile
 305                 310                 315                 320
 Gln Glu Leu Phe Lys Arg Thr Met Glu Gln Phe Thr Ala Met Phe Arg
                 325                 330                 335    
 His Lys Ala Phe Leu His Trp Tyr Thr Gly Glu Gly Met Asp Glu Met
             340                 345                 350        
 Glu Phe Thr Glu Ala Glu Ser Ser Leu Lys Asn Leu Met Ala Glu Tyr
         355                 360                 365            
 Gln Asp Ala Thr Ala Lys Ala Glu Glu Phe Glu Glu Ser Ala Glu Glu
     370                 375                 380                
 Glu Val Ala
 385        



      <210> 689
      <211> 590
      <212> PRT
      <213> Homo sapiens


      <400> 689
 Met Glu Val Ile His Gly Arg Pro Tyr Cys Cys Arg Glu Leu Glu Gly
   1               5                  10                  15    
 Ala Asp Ile Leu Ser Asn Thr Phe Tyr Ser Asn Glu Leu His Asn Pro
              20                  25                  30        
 Leu Gln Thr Val Thr Arg Pro Thr Ala Ser Glu Asp Arg Tyr Gln Glu
          35                  40                  45            
 Leu Arg Glu Ser Leu Gln Gln Cys Arg Leu Pro Trp Gly Ala Glu Arg
      50                  55                  60                
 Glu Tyr Gly Gly Ile Ile Pro Ile Ser Leu Pro Glu Asp His Arg Pro
  65                  70                  75                  80
 Lys Tyr Glu Pro Pro Arg Val Met Gly Lys Gly His Gln His Tyr Gly
                  85                  90                  95    
 Phe Gly Gly Glu Thr Trp Pro Arg Lys Leu Pro Val Glu Gln Phe Tyr
             100                 105                 110        
 Tyr Leu Thr Gln Asn Lys Lys Ser Asp Val Tyr Gly Asn Asp Ser Leu
         115                 120                 125            
 Ile Pro Lys Pro Pro Asn Ser Thr Val Gly Glu Ile Cys Leu Pro Tyr
     130                 135                 140                
 Pro Ile Glu His Pro Tyr His Thr His Ile Cys Arg Gly Thr Met Phe
 145                 150                 155                 160
 Pro Thr Phe Thr Ser Pro Glu Asp Leu Tyr Thr Gly Ile Lys Ala Arg
                 165                 170                 175    
 Thr Gln Gln Pro Phe Pro Pro Thr Val Pro Ser Lys Ala Tyr Asp Ser
             180                 185                 190        
 Thr Val Leu Lys Thr Arg Gly Asn Pro Tyr Arg Tyr Glu Leu Ile Asp
         195                 200                 205            
 Ile Pro Met Asp Ser Lys Lys Lys Ala Leu Thr Trp Pro Gly Gln Gly
     210                 215                 220                
 Val Tyr Tyr Asp Phe Pro Arg Gly Val Glu Lys Asn Lys Pro Val Phe
 225                 230                 235                 240
 Tyr Pro Lys Pro Pro Lys Thr Phe Ala Pro Asn Thr Ser Leu Asn Ser
                 245                 250                 255    
 Trp Asp Pro Ile Cys Ser Ala Lys Glu Ala Asn Ile Gln Arg Asn Leu
             260                 265                 270        
 Glu Arg Ser His Trp Leu Thr Ser Tyr Thr His Asp Phe Thr Gly Leu
         275                 280                 285            
 Gly Pro Met Asp Pro Leu Glu Leu Asp Asp Tyr Arg Glu Lys Met Val
     290                 295                 300                
 Ala Glu Leu Thr Arg Lys Ile Gly Phe Asp Pro Glu Pro Gln Glu Lys
 305                 310                 315                 320
 Phe His Pro Val Phe Lys Pro Pro Arg Pro Leu Glu Gly Arg Ile Ala
                 325                 330                 335    
 Arg Leu Ile Gln Asn Arg Arg Ser Leu Glu Ala Ile Val Gln Gln Arg
             340                 345                 350        
 Pro Arg Ser Cys Pro Asp Cys Thr Pro Arg Val Leu Cys Asn Phe His
         355                 360                 365            
 Thr Phe Val Pro Ser Ser Lys Glu Met Val Ala Leu Ser Asp Asn Ile
     370                 375                 380                
 Pro Ala Gly Val Thr His Lys Asn Gln Asp Ile Glu Glu Lys Ile Ile
 385                 390                 395                 400
 Glu Glu Gln Ser Leu Leu Ser Thr Tyr Glu Leu Pro Ser Cys Tyr Pro
                 405                 410                 415    
 Thr Lys Asp Leu Thr Ser Ile Tyr Asp Ile Lys Pro Phe Pro Lys Ile
             420                 425                 430        
 Thr Asp Thr Lys Lys Thr Glu Asp Leu Tyr Trp Arg Gln Gln Ser Leu
         435                 440                 445            
 Lys Thr Gln Pro Thr Pro Tyr Cys Lys Pro Asp His Trp Ile His Tyr
     450                 455                 460                
 Glu Asn Leu Lys Ser Pro Leu Arg Asp Gln Tyr Asn Met Cys Pro Asp
 465                 470                 475                 480
 Pro Val Ser Leu Ser Lys Pro Ser Val Leu Gln Asn Lys Gln Asp Thr
                 485                 490                 495    
 Glu Ala Phe Thr Leu Glu His Phe Leu Ser Lys Pro Glu Glu Glu Leu
             500                 505                 510        
 Phe Leu Asn Met Glu Asn Asn Glu Glu Thr Arg Pro Val Leu Gly Trp
         515                 520                 525            
 Ile Pro Arg Ala Gly Val Thr Lys Pro Gln Thr Asn Leu Leu Glu Leu
     530                 535                 540                
 Lys Asn Ser Phe Ser Lys Thr Gly Ala Gln Lys Arg Phe His Lys Ser
 545                 550                 555                 560
 Ile Leu Glu Asp His Lys Asp Leu Arg Asp Asn Glu His Ser Gly Met
                 565                 570                 575    
 Lys His Gln Phe Tyr Gly His Asn Ser Tyr Tyr Phe Tyr Asn
             580                 585                 590



      <210> 690
      <211> 174
      <212> PRT
      <213> Homo sapiens


      <400> 690
 Met Thr Pro Ser Ser Leu Thr Pro Ser Ala Arg Ser Arg Thr Thr Leu
   1               5                  10                  15    
 Ser Thr Met Leu Thr His Pro Arg Thr Pro Thr Ser Arg Arg Thr Ser
              20                  25                  30        
 Phe Ser Thr Ile Pro Ala Asn Met Gly Arg Val Arg Thr Lys Thr Val
          35                  40                  45            
 Lys Lys Ala Ala Arg Val Ile Ile Glu Lys Tyr Tyr Thr Arg Leu Gly
      50                  55                  60                
 Asn Asp Phe His Thr Asn Lys Arg Val Cys Glu Glu Ile Ala Ile Ile
  65                  70                  75                  80
 Pro Ser Lys Lys Leu Arg Asn Lys Ile Ala Gly Tyr Val Thr His Leu
                  85                  90                  95    
 Met Lys Arg Ile Gln Arg Gly Pro Val Arg Gly Ile Ser Ile Lys Leu
             100                 105                 110        
 Gln Glu Glu Glu Arg Glu Arg Arg Asp Asn Tyr Val Pro Glu Val Ser
         115                 120                 125            
 Ala Leu Asp Gln Glu Ile Ile Glu Val Asp Pro Asp Thr Lys Glu Met
     130                 135                 140                
 Leu Lys Leu Leu Asp Phe Gly Ser Leu Ser Asn Leu Gln Val Thr Gln
 145                 150                 155                 160
 Pro Thr Val Gly Met Asn Phe Lys Thr Pro Arg Gly Pro Val
                 165                 170                



      <210> 691
      <211> 1030
      <212> PRT
      <213> Homo sapiens


      <400> 691
 Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser
   1               5                  10                  15    
 Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser
              20                  25                  30        
 Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala
          35                  40                  45            
 Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala
      50                  55                  60                
 Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys
  65                  70                  75                  80
 Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr
                  85                  90                  95    
 Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu
             100                 105                 110        
 Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu
         115                 120                 125            
 Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp
     130                 135                 140                
 Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys
 145                 150                 155                 160
 His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn
                 165                 170                 175    
 Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys
             180                 185                 190        
 Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile
         195                 200                 205            
 Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro
     210                 215                 220                
 Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys
 225                 230                 235                 240
 Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly
                 245                 250                 255    
 Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro
             260                 265                 270        
 Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met
         275                 280                 285            
 Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser
     290                 295                 300                
 Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro
 305                 310                 315                 320
 Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro
                 325                 330                 335    
 Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu
             340                 345                 350        
 Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu
         355                 360                 365            
 Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr
     370                 375                 380                
 Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu
 385                 390                 395                 400
 Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile
                 405                 410                 415    
 Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val
             420                 425                 430        
 Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu
         435                 440                 445            
 Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr
     450                 455                 460                
 Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu
 465                 470                 475                 480
 Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu
                 485                 490                 495    
 Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro
             500                 505                 510        
 Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile
         515                 520                 525            
 Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu
     530                 535                 540                
 Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val
 545                 550                 555                 560
 Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu
                 565                 570                 575    
 Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala
             580                 585                 590        
 Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr
         595                 600                 605            
 Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe
     610                 615                 620                
 Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys
 625                 630                 635                 640
 Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly
                 645                 650                 655    
 Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro
             660                 665                 670        
 Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val
         675                 680                 685            
 Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro
     690                 695                 700                
 Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu
 705                 710                 715                 720
 Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys
                 725                 730                 735    
 Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys
             740                 745                 750        
 Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp
         755                 760                 765            
 Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser
     770                 775                 780                
 Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys
 785                 790                 795                 800
 Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys
                 805                 810                 815    
 Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro
             820                 825                 830        
 Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln
         835                 840                 845            
 Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys
     850                 855                 860                
 Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe
 865                 870                 875                 880
 Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys
                 885                 890                 895    
 Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly
             900                 905                 910        
 Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg
         915                 920                 925            
 Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe
     930                 935                 940                
 Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu
 945                 950                 955                 960
 Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro
                 965                 970                 975    
 Ala Thr Glu Ala Lys Pro Ser Gly Ser Pro Asn Ser Gln Arg Ser Val
             980                 985                 990        
 Ser Gln Arg Val Asn Tyr Arg Gly Asn Thr Glu Arg Thr Ser Ser Thr
         995                1000                1005            
 Phe Thr Phe Arg Pro Asn Lys Met His Gly Val Pro Glu Val Glu Asp
    1010                1015                1020                
 Arg Val Glu Asp Trp Gly
1025                1030



      <210> 692
      <211> 85
      <212> PRT
      <213> Homo sapiens


      <400> 692
 Met Ser His Gln Asp Val Ala Met Arg Thr Asp Ser Ser Lys Met Thr
   1               5                  10                  15    
 Asp Val Glu Ser Gly Val Ala Asn Phe Ala Ser Ser Ala Arg Ala Gly
              20                  25                  30        
 Arg Arg Asn Ala Leu Pro Asp Ile Gln Ser Ser Ala Ala Thr Asp Gly
          35                  40                  45            
 Thr Ser Asp Leu Pro Leu Lys Leu Glu Ala Leu Ser Val Lys Glu Asp
      50                  55                  60                
 Ala Lys Glu Lys Asp Glu Lys Thr Thr Gln Asp Gln Leu Glu Lys Pro
  65                  70                  75                  80
 Gln Asn Glu Glu Lys
                  85



      <210> 693
      <211> 115
      <212> PRT
      <213> Homo sapiens


      <400> 693
 Met Gln Val Met Asn Leu Asn Val Pro Met Arg Pro Gly Ile Leu Val
   1               5                  10                  15    
 Gln Arg Gln Ser Lys Glu Val Leu Ala Thr Pro Leu Glu Asn Arg Arg
              20                  25                  30        
 Asp Met Glu Ala Glu Glu Glu Asn Gln Ile Asn Glu Lys Gln Glu Pro
          35                  40                  45            
 Glu Asn Ala Gly Glu Thr Gly Gln Glu Glu Asp Asp Gly Leu Gln Lys
      50                  55                  60                
 Ile His Thr Ser Val Thr Arg Thr Pro Ser Val Val Glu Ser Gln Lys
  65                  70                  75                  80
 Arg Pro Leu Lys Gly Val Thr Phe Ser Arg Glu Val Ile Val Val Asp
                  85                  90                  95    
 Leu Gly Asn Glu Tyr Pro Thr Pro Arg Ser Tyr Thr Arg Glu His Lys
             100                 105                 110        
 Glu Arg Lys
         115



      <210> 694
      <211> 159
      <212> PRT
      <213> Homo sapiens


      <400> 694
 Met Glu Ile Leu Cys Leu Cys Ser Arg Leu Gly Arg Arg Ala Ser Ala
   1               5                  10                  15    
 Pro Leu Pro Gly Leu Ser Ala Pro Gly Arg Leu Phe Asp Gln Arg Phe
              20                  25                  30        
 Gly Glu Gly Leu Leu Glu Ala Glu Leu Ala Ala Leu Cys Pro Thr Thr
          35                  40                  45            
 Leu Ala Pro Tyr Tyr Leu Arg Ala Pro Ser Val Ala Leu Pro Val Ala
      50                  55                  60                
 Gln Val Pro Thr Asp Pro Gly His Phe Ser Val Leu Leu Asp Val Lys
  65                  70                  75                  80
 His Phe Ser Pro Glu Glu Ile Ala Val Lys Val Val Gly Glu His Val
                  85                  90                  95    
 Glu Val His Ala Arg His Glu Glu Arg Pro Asp Glu His Gly Phe Val
             100                 105                 110        
 Ala Arg Glu Phe His Arg Arg Tyr Arg Leu Pro Pro Gly Val Asp Pro
         115                 120                 125            
 Ala Ala Val Thr Ser Ala Leu Ser Pro Glu Gly Val Leu Ser Ile Gln
     130                 135                 140                
 Ala Ala Pro Ala Ser Ala Gln Ala Pro Pro Pro Ala Ala Ala Lys
 145                 150                 155                



      <210> 695
      <211> 499
      <212> PRT
      <213> Homo sapiens


      <400> 695
 Met Val Glu Lys Lys Glu Pro Tyr Ser Arg Ala Ser Gly His Pro Gly
   1               5                  10                  15    
 Leu Gly Gly His Ser Gly Ser Val Gln Gly Ala Cys Thr Pro Leu Gly
              20                  25                  30        
 Ala Thr His Ser Arg Pro Asn Tyr Thr Arg Lys Arg Asp Thr Arg Ser
          35                  40                  45            
 Glu Ser Leu Glu Ile Pro Ile Ser Val Val Leu Pro Gln Leu Pro Glu
      50                  55                  60                
 Thr Ala Gln Arg Ser Arg Arg Arg Glu Gly Gly Leu Arg Gln Leu Lys
  65                  70                  75                  80
 Leu Val Leu Gly Leu Pro Ala Ser Cys Ala Gly Gly Pro Gly Ala Ala
                  85                  90                  95    
 Ala Gly Val Leu Trp Gly Arg Arg Gly Thr Ala Glu Pro Phe Pro Arg
             100                 105                 110        
 Leu His Asn Leu Tyr Ser Thr Pro Arg Cys Ala Gln Gln Ala Ala Leu
         115                 120                 125            
 Pro Arg Leu Ser Arg Arg Met Ala Ser Gln His Ser Tyr Pro Leu Asn
     130                 135                 140                
 Arg Phe Ser Ser Val Pro Leu Asp Pro Met Glu Arg Pro Met Ser Gln
 145                 150                 155                 160
 Ala Asp Leu Glu Leu Asp Tyr Asn Pro Pro Arg Val Gln Leu Ser Asp
                 165                 170                 175    
 Glu Met Phe Val Phe Gln Asp Gly Arg Trp Val Asn Glu Asn Cys Arg
             180                 185                 190        
 Leu Gln Ser Pro Tyr Phe Ser Pro Ser Ala Ser Phe His His Lys Leu
         195                 200                 205            
 His His Lys Arg Leu Ala Lys Glu Cys Met Leu Gln Glu Glu Asn Lys
     210                 215                 220                
 Ser Leu Arg Glu Glu Asn Lys Ala Leu Arg Glu Glu Asn Arg Met Leu
 225                 230                 235                 240
 Ser Lys Glu Asn Lys Ile Leu Gln Val Phe Trp Glu Glu His Lys Ala
                 245                 250                 255    
 Ser Leu Gly Arg Glu Glu Ser Arg Ala Pro Ser Pro Leu Leu His Lys
             260                 265                 270        
 Asp Ser Ala Ser Leu Glu Val Val Lys Lys Asp His Val Ala Leu Gln
         275                 280                 285            
 Val Pro Arg Gly Lys Glu Asp Ser Thr Leu Gln Leu Leu Arg Glu Glu
     290                 295                 300                
 Asn Arg Ala Leu Gln Gln Leu Leu Glu Gln Lys Gln Ala Tyr Trp Ala
 305                 310                 315                 320
 Gln Ala Glu Asp Thr Ala Ala Pro Ala Glu Glu Ser Lys Pro Ala Pro
                 325                 330                 335    
 Ser Pro His Glu Glu Pro Cys Ser Pro Gly Leu Leu Gln Asp Gln Gly
             340                 345                 350        
 Ser Gly Leu Ser Ser Arg Phe Glu Glu Pro Lys Gly Pro Pro Ala Arg
         355                 360                 365            
 Gln Glu Asp Ser Lys Glu Leu Arg Ala Leu Arg Lys Met Val Ser Asn
     370                 375                 380                
 Met Ser Gly Pro Ser Gly Glu Glu Glu Ala Lys Val Gly Pro Gly Leu
 385                 390                 395                 400
 Pro Asp Gly Cys Gln Pro Leu Gln Leu Leu Arg Glu Met Arg Gln Ala
                 405                 410                 415    
 Leu Gln Ala Leu Leu Lys Glu Asn Arg Leu Leu Gln Glu Glu Asn Arg
             420                 425                 430        
 Thr Leu Gln Val Leu Arg Ala Glu His Arg Gly Phe Gln Glu Glu Asn
         435                 440                 445            
 Lys Ala Leu Trp Glu Asn Asn Lys Leu Lys Leu Gln Gln Lys Leu Val
     450                 455                 460                
 Ile Asp Thr Val Thr Glu Val Thr Ala Arg Met Glu Met Leu Ile Glu
 465                 470                 475                 480
 Glu Leu Tyr Ala Phe Met Pro Ala Arg Ser Gln Asp Pro Lys Lys Pro
                 485                 490                 495    
 Ser Arg Val
            



      <210> 696
      <211> 253
      <212> PRT
      <213> Homo sapiens


      <400> 696
 Met Met Met Gly Cys Gly Glu Ser Glu Leu Lys Ser Ala Asp Gly Glu
   1               5                  10                  15    
 Glu Ala Ala Ala Val Pro Gly Pro Pro Pro Glu Pro Gln Val Pro Gln
              20                  25                  30        
 Leu Arg Ala Pro Val Pro Glu Pro Gly Leu Asp Leu Ser Leu Ser Pro
          35                  40                  45            
 Arg Pro Asp Ser Pro Gln Pro Arg His Gly Ser Pro Gly Arg Arg Lys
      50                  55                  60                
 Gly Arg Ala Glu Arg Arg Gly Ala Ala Arg Gln Arg Arg Gln Val Arg
  65                  70                  75                  80
 Phe Arg Leu Thr Pro Pro Ser Pro Val Arg Ser Glu Pro Gln Pro Ala
                  85                  90                  95    
 Val Pro Gln Glu Leu Glu Met Pro Val Leu Lys Ser Ser Leu Ala Leu
             100                 105                 110        
 Gly Leu Glu Leu Arg Ala Ala Ala Gly Ser His Phe Asp Ala Ala Lys
         115                 120                 125            
 Ala Val Glu Glu Gln Leu Arg Lys Ser Phe Gln Ile Arg Cys Gly Leu
     130                 135                 140                
 Glu Glu Ser Val Ser Glu Gly Leu Asn Val Pro Arg Ser Lys Arg Leu
 145                 150                 155                 160
 Phe Arg Asp Leu Val Ser Leu Gln Val Pro Glu Glu Gln Val Leu Asn
                 165                 170                 175    
 Ala Ala Leu Arg Glu Lys Leu Ala Leu Leu Pro Pro Gln Ala Arg Ala
             180                 185                 190        
 Pro His Pro Lys Glu Pro Pro Gly Pro Gly Pro Asp Met Thr Ile Leu
         195                 200                 205            
 Cys Asp Pro Glu Thr Leu Phe Tyr Glu Ser Pro His Leu Thr Leu Asp
     210                 215                 220                
 Gly Leu Pro Pro Leu Arg Leu Gln Leu Arg Pro Arg Pro Ser Glu Asp
 225                 230                 235                 240
 Thr Phe Leu Met His Arg Thr Leu Arg Arg Trp Glu Ala
                 245                 250            



      <210> 697
      <211> 526
      <212> PRT
      <213> Homo sapiens


      <400> 697
 Met Gly Ser Ser Ser Ser Arg Val Leu Gly Gln Pro Arg Arg Ala Leu
   1               5                  10                  15    
 Ala Gln Gln Glu Gln Gly Ala Arg Ala Arg Gly Ser Ala Arg Arg Pro
              20                  25                  30        
 Asp Thr Gly Asp Asp Ala Ala Ser Tyr Gly Phe Cys Tyr Cys Pro Gly
          35                  40                  45            
 Ser His Lys Arg Lys Arg Ser Ser Gly Ala Cys Arg Tyr Cys Asp Pro
      50                  55                  60                
 Asp Ser His Arg Glu Glu His Glu Glu Glu Gly Asp Lys Gln Gln Pro
  65                  70                  75                  80
 Leu Leu Asn Thr Pro Ala Arg Lys Lys Leu Arg Ser Thr Ser Lys Tyr
                  85                  90                  95    
 Ile Tyr Gln Thr Leu Phe Leu Asn Gly Glu Asn Ser Asp Ile Lys Ile
             100                 105                 110        
 Cys Ala Leu Gly Glu Glu Trp Arg Leu His Lys Ile Tyr Leu Cys Gln
         115                 120                 125            
 Ser Gly Tyr Phe Ser Ser Met Phe Ser Gly Ser Trp Lys Glu Ser Ser
     130                 135                 140                
 Met Asn Ile Ile Glu Leu Glu Ile Pro Asp Gln Asn Ile Asp Val Asp
 145                 150                 155                 160
 Ala Leu Gln Val Ala Phe Gly Ser Leu Tyr Arg Asp Asp Val Leu Ile
                 165                 170                 175    
 Lys Pro Ser Arg Val Val Ala Ile Leu Ala Ala Ala Cys Met Leu Gln
             180                 185                 190        
 Leu Asp Gly Leu Ile Gln Gln Cys Gly Glu Thr Met Lys Glu Thr Ile
         195                 200                 205            
 Asn Val Lys Thr Val Cys Gly Tyr Tyr Thr Ser Val Glu Ile Tyr Gly
     210                 215                 220                
 Leu Asp Ser Val Lys Lys Lys Cys Leu Glu Trp Leu Leu Asn Asn Leu
 225                 230                 235                 240
 Met Thr His Gln Asn Val Lys Leu Phe Lys Glu Leu Gly Ile Asn Val
                 245                 250                 255    
 Met Lys Gln Leu Ile Gly Ser Ser Asn Leu Phe Val Met Gln Val Glu
             260                 265                 270        
 Met Asp Val Tyr Thr Thr Leu Lys Lys Trp Met Phe Leu Gln Leu Val
         275                 280                 285            
 Pro Ser Trp Asn Gly Ser Leu Lys Gln Leu Leu Thr Glu Thr Asp Val
     290                 295                 300                
 Trp Phe Ser Lys Gln Arg Lys Asp Phe Glu Gly Met Ala Phe Leu Glu
 305                 310                 315                 320
 Thr Glu Pro Gly Lys Pro Phe Val Ser Val Phe Arg His Leu Arg Leu
                 325                 330                 335    
 Gln Tyr Ile Ile Ser Asp Leu Ala Ser Ala Arg Ile Ile Glu Gln Asp
             340                 345                 350        
 Gly Ile Val Pro Ser Glu Trp Leu Ser Ser Val Tyr Lys Gln Gln Trp
         355                 360                 365            
 Phe Ala Met Leu Arg Ala Glu Gln Asp His Glu Val Gly Pro Gln Glu
     370                 375                 380                
 Ile Asn Lys Glu Asp Leu Glu Gly Ser Ser Met Arg Cys Gly Arg Lys
 385                 390                 395                 400
 Leu Ala Lys Asp Gly Glu Tyr Tyr Trp Cys Trp Thr Gly Phe Asn Phe
                 405                 410                 415    
 Gly Phe Asp Leu Leu Val Ile Tyr Thr Asn Gly Tyr Ile Ile Phe Lys
             420                 425                 430        
 Arg Asn Thr Leu Asn Gln Pro Cys Ser Gly Ser Val Ser Leu Arg Pro
         435                 440                 445            
 Arg Arg Ser Ile Ala Phe Arg Leu Arg Leu Ala Ser Phe Asp Ser Ser
     450                 455                 460                
 Gly Lys Leu Val Cys Ser Arg Thr Thr Gly Tyr Gln Ile Leu Ile Leu
 465                 470                 475                 480
 Lys Lys Asp Gln Glu Gln Val Val Met Asn Leu Asp Ser Arg Phe Leu
                 485                 490                 495    
 Thr Phe Pro Leu Tyr Ile Cys Cys Asn Phe Leu Tyr Ile Ser Pro Glu
             500                 505                 510        
 Lys Gly Ile Glu Asn Asn Arg His Pro Glu Asp Pro Glu Asn
         515                 520                 525    



      <210> 698
      <211> 147
      <212> PRT
      <213> Homo sapiens


      <400> 698
 Met Arg Lys Asn Gln His Lys Asn Ser Gly Asn Ser Lys Ser Gln Ser
   1               5                  10                  15    
 Val Phe Leu Pro Pro Asn Asp His Thr Ser Ser Pro Ala Met Val Leu
              20                  25                  30        
 Asn Gln Ala Glu Met Ala Glu Met Thr Asp Ile Glu Phe Arg Ile Trp
          35                  40                  45            
 Met Ala Met Lys Ile Ile Glu Ile Gln Glu Lys Val Glu Thr Gln Ser
      50                  55                  60                
 Lys Glu Ser Lys Glu Ser Ser Lys Met Ile Gln Glu Leu Lys Asp Glu
  65                  70                  75                  80
 Ile Ala Ile Leu Arg Lys Asn Gln Thr Asp Leu Ile Glu Leu Lys Asn
                  85                  90                  95    
 Ser Leu Gln Glu Phe Gln Asn Thr Ile Ala Ser Ile Asn Ser Arg Ile
             100                 105                 110        
 Asp Gln Ala Glu Glu Arg Ile Ser Glu Leu Glu Asp Trp Leu Ser Glu
         115                 120                 125            
 Ile Thr Gln Thr Thr Thr Thr Thr Thr Lys Ser Lys His Lys Asn Glu
     130                 135                 140                
 Arg Lys Leu
 145        



      <210> 699
      <211> 220
      <212> PRT
      <213> Homo sapiens


      <400> 699
 Met Asn Leu Gly Asp Gly Leu Lys Leu Glu Thr Glu Leu Leu Asp Gly
   1               5                  10                  15    
 Lys Thr Lys Leu Ile Leu Ser Pro Tyr Glu His Lys Ser Lys Ile Ser
              20                  25                  30        
 Val Lys Met Gly Asn Lys Ala Lys Ile Ala Lys Cys Pro Leu Arg Thr
          35                  40                  45            
 Lys Thr Gly His Ile Leu Lys Ser Thr Gln Asp Thr Cys Ile Gly Ser
      50                  55                  60                
 Glu Lys Leu Leu Gln Lys Lys Pro Val Gly Ser Glu Thr Ser Gln Ala
  65                  70                  75                  80
 Lys Gly Glu Lys Asn Gly Met Thr Phe Ser Ser Thr Lys Asp Leu Cys
                  85                  90                  95    
 Lys Gln Cys Ile Asp Lys Asp Cys Leu His Ile Gln Lys Glu Ile Ser
             100                 105                 110        
 Pro Ala Thr Pro Asn Met Gln Lys Thr Arg Asn Thr Val Asn Thr Ser
         115                 120                 125            
 Leu Val Gly Lys Gln Lys Pro His Lys Lys His Ile Thr Ala Glu Asn
     130                 135                 140                
 Met Lys Ser Ser Leu Val Cys Leu Thr Gln Asp Gln Leu Gln Gln Ile
 145                 150                 155                 160
 Leu Met Thr Val Asn Gln Gly Asn Arg Ser Leu Ser Leu Thr Glu Asn
                 165                 170                 175    
 Gly Lys Glu Ala Lys Ser Gln Tyr Ser Leu Tyr Leu Asn Ser Ile Ser
             180                 185                 190        
 Asn Gln Pro Lys Asp Glu Asn Ile Met Gly Leu Phe Lys Lys Thr Glu
         195                 200                 205            
 Met Val Ser Ser Val Pro Ala Glu Asn Lys Ser Val
     210                 215                 220



      <210> 700
      <211> 234
      <212> PRT
      <213> Homo sapiens


      <400> 700
 Met Ala Glu Gly Gly Ser Pro Asp Gly Arg Ala Gly Pro Gly Ser Ala
   1               5                  10                  15    
 Gly Arg Asn Leu Lys Glu Trp Leu Arg Glu Gln Phe Cys Asp His Pro
              20                  25                  30        
 Leu Glu His Cys Glu Asp Thr Arg Leu His Asp Ala Ala Tyr Val Gly
          35                  40                  45            
 Asp Leu Gln Thr Leu Arg Ser Leu Leu Gln Glu Glu Ser Tyr Arg Arg
      50                  55                  60                
 Tyr Gly Ala Asp Val Asp Val Asn His His Leu Thr Pro Asp Val Gln
  65                  70                  75                  80
 Pro Arg Phe Ser Arg Arg Leu Thr Ser Leu Val Val Cys Pro Leu Tyr
                  85                  90                  95    
 Ile Ser Ala Ala Tyr His Asn Leu Gln Cys Phe Arg Leu Leu Leu Leu
             100                 105                 110        
 Ala Gly Ala Asn Pro Asp Phe Asn Cys Asn Gly Pro Val Asn Thr Gln
         115                 120                 125            
 Gly Phe Tyr Arg Gly Ser Pro Gly Cys Val Met Asp Ala Val Leu Arg
     130                 135                 140                
 His Gly Cys Glu Ala Ala Phe Val Ser Leu Leu Val Glu Phe Gly Ala
 145                 150                 155                 160
 Asn Leu Asn Leu Val Lys Trp Glu Ser Leu Gly Pro Glu Ser Arg Gly
                 165                 170                 175    
 Arg Arg Lys Val Asp Pro Glu Ala Leu Gln Val Phe Lys Glu Ala Arg
             180                 185                 190        
 Ser Val Pro Arg Thr Leu Leu Cys Leu Cys Arg Val Ala Val Arg Arg
         195                 200                 205            
 Ala Leu Gly Lys His Arg Leu His Leu Ile Pro Ser Leu Pro Leu Pro
     210                 215                 220                
 Asp Pro Ile Lys Lys Phe Leu Leu His Glu
 225                 230                



      <210> 701
      <211> 89
      <212> PRT
      <213> Homo sapiens


      <400> 701
 Met Ser Ser Gln Gln Gln Lys Gln Pro Cys Thr Pro Pro Pro Gln Leu
   1               5                  10                  15    
 Gln Gln Gln Gln Val Lys Gln Pro Cys Gln Pro Pro Pro Gln Glu Pro
              20                  25                  30        
 Cys Ile Pro Lys Thr Lys Glu Pro Cys His Pro Lys Val Pro Glu Pro
          35                  40                  45            
 Cys His Pro Lys Val Pro Glu Pro Cys Gln Ala Lys Val Pro Glu Pro
      50                  55                  60                
 Cys Leu Pro Lys Val Pro Glu Pro Cys Pro Ser Ile Val Ser Pro Ala
  65                  70                  75                  80
 Ser Val Gln Gln Thr Pro Lys Gln Lys
                  85                



      <210> 702
      <211> 870
      <212> PRT
      <213> Homo sapiens


      <400> 702
 Met His Leu Ala Arg Cys Arg Trp Ala Ser Ala Pro Pro Leu Tyr Thr
   1               5                  10                  15    
 Leu Ile Asp Val Leu Lys Tyr Ser Tyr Val Arg Leu Val Cys Lys Asp
              20                  25                  30        
 Val Arg Ala Pro Ser Arg Pro Ala Val Gly Pro Pro Gln Pro Gly Cys
          35                  40                  45            
 Pro Ala Phe Ile Ile Val Lys Leu Ser Pro Leu Arg Asp Arg Leu Val
      50                  55                  60                
 Val Thr Glu Cys Gln Leu Thr His Ser His Pro Ala Cys Pro Leu Glu
  65                  70                  75                  80
 Phe Ala Tyr Tyr Phe Arg Pro Gly His Leu Leu Ala Asn Ala Cys Leu
                  85                  90                  95    
 Pro Val Arg Thr Thr Asn Lys Ile Ser Lys Gln Phe Val Ala Pro Ala
             100                 105                 110        
 Asp Val Arg Arg Leu Leu Ser Tyr Cys Lys Gly Arg Asp His Gly Val
         115                 120                 125            
 Leu Asp Ala Leu His Val Leu Glu Gly Leu Phe Arg Thr Asp Pro Glu
     130                 135                 140                
 Ala Lys Val Lys Leu Val Phe Val Glu Asp Gln Ala Val Val Glu Thr
 145                 150                 155                 160
 Val Phe Phe Leu Thr Ser Arg Thr Arg Ala Leu Leu Arg Arg Phe Pro
                 165                 170                 175    
 Arg Met Leu Leu Val Asp Arg Leu Pro Gly Leu Gln Gly Ala Leu Asp
             180                 185                 190        
 Leu Leu Ala Val Leu Cys Val Asp Gly Ser Gly Arg Ala Arg Gln Ala
         195                 200                 205            
 Ala Cys Cys Val Ala Arg Pro Gly Thr Pro Ser Leu Leu Arg Phe Ala
     210                 215                 220                
 Leu Ala Ser Leu Leu Gln Ser Ala Pro Asp Val Lys Gly Arg Val Arg
 225                 230                 235                 240
 Cys Leu Thr Ala Gly Pro Glu Val Ala Ala Gln Leu Pro Ala Val Arg
                 245                 250                 255    
 Gln Leu Leu Pro Cys Ala Arg Val Gln Ile Cys Arg Ala Gln Gly Leu
             260                 265                 270        
 Glu Thr Leu Phe Ser Lys Ala Gln Glu Leu Gly Gly Ala Gly Arg Glu
         275                 280                 285            
 Asp Pro Gly Leu Trp Ser Arg Leu Cys Arg Leu Ala Gly Ala Ser Ser
     290                 295                 300                
 Pro Ala Ala Tyr Asp Glu Ala Leu Ala Glu Leu His Ala His Gly Pro
 305                 310                 315                 320
 Ala Ala Phe Val Asp Tyr Phe Glu Arg Asn Trp Glu Pro Arg Arg Asp
                 325                 330                 335    
 Met Trp Val Arg Phe Arg Ala Phe Glu Ala Ala Arg Asp Leu Asp Ala
             340                 345                 350        
 Cys Ala Leu Val Arg Gly His Arg Arg Arg Leu Leu Arg Arg Leu Ser
         355                 360                 365            
 Pro Ser Arg Gly Val Ala Gln Cys Leu Arg Asp Leu Val Ala Met Gln
     370                 375                 380                
 Trp Ala Asp Ala Ala Gly Glu Ala Val Pro Glu Gly Pro Asp Gly Gly
 385                 390                 395                 400
 Gly Pro Trp Leu Glu Asp Glu Pro Gly Arg Gly Ala Gln Gly Glu Asn
                 405                 410                 415    
 Glu Arg Val Arg Gly Leu Glu Thr Gly Asp Trp Gly Gly Ala Pro Lys
             420                 425                 430        
 Glu Gly Ser Ile Trp Arg Gly Ala Gln Met Glu Lys Glu Trp Ala Arg
         435                 440                 445            
 Ala Leu Glu Thr Arg Asp Trp Gly Gly Ala Gln Phe Glu Gly Glu Lys
     450                 455                 460                
 Gly Arg Ala Leu Gln Ile Arg Asp Trp Arg Gly Gly Arg Leu Glu Asn
 465                 470                 475                 480
 Gln Lys Pro Arg Gly Leu Glu Gly Gly Val Leu Arg Gly Ser Lys Leu
                 485                 490                 495    
 Glu Lys Gly His Leu Arg Gly Pro Glu Ile Arg Asp Trp Arg Gly Pro
             500                 505                 510        
 Gln Leu Glu Gly Glu Lys Asp Trp Gly Leu Glu Gly Tyr Val Trp Arg
         515                 520                 525            
 Gly Ser Gln Leu Glu Asp Gln Ala Leu Arg Gly Leu Glu Gly Tyr Thr
     530                 535                 540                
 Trp Arg Val Ala Gln Leu Glu Asp Arg Arg Ser Thr Thr Asp Leu Arg
 545                 550                 555                 560
 Gly Thr Gln Phe Asp Tyr Glu Arg Val Arg Ser Leu Glu Gly Ser Pro
                 565                 570                 575    
 Trp Arg Gly Ala Gln Leu His Asp Glu Arg Ala Gly Gly Leu Arg Thr
             580                 585                 590        
 Ala Glu Trp Lys Gly Pro Gln Ser Glu Val Glu Lys Gly Arg Gly Leu
         595                 600                 605            
 Glu Val Arg Asn Leu Arg Gly Ile Pro Leu Glu Lys Ser Leu Glu Leu
     610                 615                 620                
 Ala Pro Glu Asn Gly Asp Gln Arg Gly Pro Gln Trp Glu Asp Glu Arg
 625                 630                 635                 640
 Arg Arg Gly Pro Glu Ile Ala Glu Glu Arg Gly Ala Arg Val Gly Val
                 645                 650                 655    
 Lys Arg Arg Arg Gly Leu Glu Asp Ile Val Leu Val Gln Leu Gly Asp
             660                 665                 670        
 Thr Arg Val Thr Gly Met Glu Asn Gly Asp Gly Gly Gly Ala Arg Ser
         675                 680                 685            
 Val Gly Pro Lys Ser Arg Ala Gly Arg Gly Met Glu Trp Gly Asp Ala
     690                 695                 700                
 Gly Gly Arg Cys Leu Gly Leu Gly Asn Gly Val Val Ser Gly Thr Pro
 705                 710                 715                 720
 Val Gly Thr Val Leu Glu Gly Ser Pro Glu Trp Ala Ala Ala Arg Ser
                 725                 730                 735    
 Glu His Leu Ala Ala Gly Asp Gly Leu Gln Glu Gly Gly Glu Asp Gly
             740                 745                 750        
 Pro Arg Glu Pro Lys Arg Leu Cys Arg Pro Pro Gly Glu Glu Glu Val
         755                 760                 765            
 Asp Trp Glu Pro Leu Ala Lys Phe Arg Ala Ala Cys Gly Pro Glu Leu
     770                 775                 780                
 Ala Asp Leu Val Ala Glu Glu Leu Ala Phe Ala Arg Gln His Gly Thr
 785                 790                 795                 800
 Arg Gly Phe His Trp Thr Gly Ala Gly Phe Ala Leu Lys Asp Gly Thr
                 805                 810                 815    
 Ser Asp Phe Phe Leu Asp Gly Ala Leu Thr Arg Cys Ser Cys Ser Ile
             820                 825                 830        
 His Ala Ala Arg Arg Leu Pro Cys Arg His Leu Phe Ala Ala Arg Leu
         835                 840                 845            
 Leu Thr Gly Ala Ala Leu Phe His Met Asp Leu Leu Arg Asp Cys Trp
     850                 855                 860                
 Gly Arg Ala Pro Glu Pro
 865                 870



      <210> 703
      <211> 197
      <212> PRT
      <213> Homo sapiens


      <400> 703
 Met Ser Glu Thr Gln Asn Ser Thr Ser Gln Lys Ala Met Asp Glu Asp
   1               5                  10                  15    
 Asn Lys Ala Ala Ser Gln Thr Met Pro Asn Thr Gln Asp Lys Asn Tyr
              20                  25                  30        
 Glu Asp Glu Leu Thr Gln Val Ala Leu Ala Leu Val Glu Asp Val Ile
          35                  40                  45            
 Asn Tyr Ala Val Lys Ile Val Glu Glu Glu Arg Asn Pro Leu Lys Asn
      50                  55                  60                
 Ile Lys Trp Met Thr His Gly Glu Phe Thr Val Glu Lys Gly Leu Lys
  65                  70                  75                  80
 Gln Ile Asp Glu Tyr Phe Ser Lys Cys Val Ser Lys Lys Cys Trp Ala
                  85                  90                  95    
 His Gly Val Glu Phe Val Glu Arg Lys Asp Leu Ile His Ser Phe Leu
             100                 105                 110        
 Tyr Ile Tyr Tyr Val His Trp Ser Ile Ser Thr Ala Asp Leu Pro Val
         115                 120                 125            
 Ala Arg Ile Ser Ala Gly Thr Tyr Phe Thr Met Lys Val Ser Lys Thr
     130                 135                 140                
 Lys Pro Pro Asp Ala Pro Ile Val Val Ser Tyr Val Gly Asp His Gln
 145                 150                 155                 160
 Ala Leu Val His Arg Pro Gly Met Val Arg Phe Arg Glu Asn Trp Gln
                 165                 170                 175    
 Lys Asn Leu Thr Asp Ala Lys Tyr Ser Phe Met Glu Ser Phe Pro Phe
             180                 185                 190        
 Leu Phe Asn Arg Val
         195        



      <210> 704
      <211> 147
      <212> PRT
      <213> Homo sapiens


      <400> 704
 Met Ala Pro Pro Leu Gln Gly Pro Gly Gly Ala Ala Gly Gly Arg Thr
   1               5                  10                  15    
 Asp Gly Gln Ala Ala Trp Val Ala Gly Pro Arg Lys Ala Gly Val Asp
              20                  25                  30        
 Val Arg Asp Glu Pro Pro Ala Lys Pro Val Gly Met Ser Gly Pro Ser
          35                  40                  45            
 Trp Trp Asp Cys Leu Gly His Arg His Gln His Gly Val Arg Ala Ile
      50                  55                  60                
 Ser Gly Asp Ile Gly Gly Ala Thr Thr Arg Trp Gly Ile Phe Asn Arg
  65                  70                  75                  80
 Leu Glu Pro Leu Arg Leu Glu Arg Pro Thr Pro Gly Arg Arg Pro Pro
                  85                  90                  95    
 Leu Thr Pro Leu Leu Pro Leu Leu Trp Asp Pro Pro Val Asp Thr Pro
             100                 105                 110        
 Asp Glu Asp Thr Gln Glu Ala Ser Ser Gln Asp Arg Arg Gln Leu Ala
         115                 120                 125            
 Gly Gln Pro Arg Ser Ala Gly Phe Arg Ala Leu Gln Gln Glu Leu His
     130                 135                 140                
 Gly Asp Gly
 145        



      <210> 705
      <211> 164
      <212> PRT
      <213> Homo sapiens


      <400> 705
 Met Asp Met Gly Thr Ser Ala Leu Ser Lys Lys Pro Trp Trp Thr Leu
   1               5                  10                  15    
 Pro Gln Asn Phe His Ala Pro Met Val Phe His Met Glu Glu Asp Gln
              20                  25                  30        
 Glu Glu Leu Ile Phe Gly His Gly Asp Thr Tyr Leu Arg Cys Ile Glu
          35                  40                  45            
 Val His Ser His Thr Leu Ile Gln Leu Glu Ser Trp Phe Thr Ala Thr
      50                  55                  60                
 Gly Gln Thr Arg Val Thr Val Val Gly Pro His Arg Ala Arg Gln Trp
  65                  70                  75                  80
 Leu Leu His Met Phe Cys Cys Val Gly Ser Gln Asp Ser Tyr His His
                  85                  90                  95    
 Ala Arg Gly Leu Glu Met Leu Glu Arg Val Arg Ser Gln Pro Leu Thr
             100                 105                 110        
 Asn Asp Asp Leu Val Thr Ser Ile Ser Val Pro Pro Tyr Thr Gly Asp
         115                 120                 125            
 Leu Ser Leu Ala Pro Arg Ile Ser Gly Thr Val Cys Leu Ser Val Pro
     130                 135                 140                
 Gln Pro Ser Pro Tyr Gln Val Ile Gly Cys Ser Gly Phe His Leu Ser
 145                 150                 155                 160
 Ser Leu Tyr Pro
                



      <210> 706
      <211> 686
      <212> PRT
      <213> Homo sapiens


      <400> 706
 Met Ala Glu Ala Ala Glu Pro Glu Gly Val Ala Pro Gly Pro Gln Gly
   1               5                  10                  15    
 Pro Pro Glu Val Pro Ala Pro Leu Ala Glu Arg Pro Gly Glu Pro Gly
              20                  25                  30        
 Ala Ala Gly Gly Glu Ala Glu Gly Pro Glu Gly Ser Glu Gly Ala Glu
          35                  40                  45            
 Glu Ala Pro Arg Gly Ala Ala Ala Val Lys Glu Ala Gly Gly Gly Gly
      50                  55                  60                
 Pro Asp Arg Gly Pro Glu Ala Glu Ala Arg Gly Thr Arg Gly Ala His
  65                  70                  75                  80
 Gly Glu Thr Glu Ala Glu Glu Gly Ala Pro Glu Gly Ala Glu Val Pro
                  85                  90                  95    
 Gln Gly Gly Glu Glu Thr Ser Gly Ala Gln Gln Val Glu Gly Ala Ser
             100                 105                 110        
 Pro Gly Arg Gly Ala Gln Gly Glu Pro Arg Gly Glu Ala Gln Arg Glu
         115                 120                 125            
 Pro Glu Asp Ser Ala Ala Pro Glu Arg Gln Glu Glu Ala Glu Gln Arg
     130                 135                 140                
 Pro Glu Val Pro Glu Gly Ser Ala Ser Gly Glu Ala Gly Asp Ser Val
 145                 150                 155                 160
 Asp Ala Glu Gly Pro Leu Gly Asp Asn Ile Glu Ala Glu Gly Pro Ala
                 165                 170                 175    
 Gly Asp Ser Val Glu Ala Glu Gly Arg Val Gly Asp Ser Val Asp Ala
             180                 185                 190        
 Glu Gly Pro Ala Gly Asp Ser Val Asp Ala Glu Gly Pro Leu Gly Asp
         195                 200                 205            
 Asn Ile Gln Ala Glu Gly Pro Ala Gly Asp Ser Val Asp Ala Glu Gly
     210                 215                 220                
 Arg Val Gly Asp Ser Val Asp Ala Glu Gly Pro Ala Gly Asp Ser Val
 225                 230                 235                 240
 Asp Ala Glu Gly Arg Val Gly Asp Ser Val Glu Ala Gly Asp Pro Ala
                 245                 250                 255    
 Gly Asp Gly Val Glu Ala Gly Val Pro Ala Gly Asp Ser Val Glu Ala
             260                 265                 270        
 Glu Gly Pro Ala Gly Asp Ser Met Asp Ala Glu Gly Pro Ala Gly Arg
         275                 280                 285            
 Ala Arg Arg Val Ser Gly Glu Pro Gln Gln Ser Gly Asp Gly Ser Leu
     290                 295                 300                
 Ser Pro Gln Ala Glu Ala Ile Glu Val Ala Ala Gly Glu Ser Ala Gly
 305                 310                 315                 320
 Arg Ser Pro Gly Glu Leu Ala Trp Asp Ala Ala Glu Glu Ala Glu Val
                 325                 330                 335    
 Pro Gly Val Lys Gly Ser Glu Glu Ala Ala Pro Gly Asp Ala Arg Ala
             340                 345                 350        
 Asp Ala Gly Glu Asp Arg Val Gly Asp Gly Pro Gln Gln Glu Pro Gly
         355                 360                 365            
 Glu Asp Glu Glu Arg Arg Glu Arg Ser Pro Glu Gly Pro Arg Glu Glu
     370                 375                 380                
 Glu Ala Ala Gly Gly Glu Glu Glu Ser Pro Asp Ser Ser Pro His Gly
 385                 390                 395                 400
 Glu Ala Ser Arg Gly Ala Ala Glu Pro Glu Ala Gln Leu Ser Asn His
                 405                 410                 415    
 Leu Ala Glu Glu Gly Pro Ala Glu Gly Ser Gly Glu Ala Ala Arg Val
             420                 425                 430        
 Asn Gly Arg Arg Glu Asp Gly Glu Ala Ser Glu Pro Arg Ala Leu Gly
         435                 440                 445            
 Gln Glu His Asp Ile Thr Leu Phe Val Lys Ala Gly Tyr Asp Gly Glu
     450                 455                 460                
 Ser Ile Gly Asn Cys Pro Phe Ser Gln Arg Leu Phe Met Ile Leu Trp
 465                 470                 475                 480
 Leu Lys Gly Val Ile Phe Asn Val Thr Thr Val Asp Leu Lys Arg Lys
                 485                 490                 495    
 Pro Ala Asp Leu Gln Asn Leu Ala Pro Gly Thr Asn Pro Pro Phe Met
             500                 505                 510        
 Thr Phe Asp Gly Glu Val Lys Thr Asp Val Asn Lys Ile Glu Glu Phe
         515                 520                 525            
 Leu Glu Glu Lys Leu Ala Pro Pro Arg Tyr Pro Lys Leu Gly Thr Gln
     530                 535                 540                
 His Pro Glu Ser Asn Ser Ala Gly Asn Asp Val Phe Ala Lys Phe Ser
 545                 550                 555                 560
 Ala Phe Ile Lys Asn Thr Lys Lys Asp Ala Asn Glu Ile His Glu Lys
                 565                 570                 575    
 Asn Leu Leu Lys Ala Leu Arg Lys Leu Asp Asn Tyr Leu Asn Ser Pro
             580                 585                 590        
 Leu Pro Asp Glu Ile Asp Ala Tyr Ser Thr Glu Asp Val Thr Val Ser
         595                 600                 605            
 Gly Arg Lys Phe Leu Gly Gly Asp Glu Leu Thr Leu Ala Asp Cys Asn
     610                 615                 620                
 Leu Leu Pro Lys Leu His Ile Ile Lys Ile Val Ala Lys Lys Tyr Arg
 625                 630                 635                 640
 Asp Phe Glu Phe Pro Ser Glu Met Thr Gly Ile Trp Arg Tyr Leu Asn
                 645                 650                 655    
 Asn Ala Tyr Ala Arg Asp Glu Phe Thr Asn Thr Cys Pro Ala Asp Gln
             660                 665                 670        
 Glu Ile Glu His Ala Tyr Ser Asp Val Ala Lys Arg Met Lys
         675                 680                 685    



      <210> 707
      <211> 247
      <212> PRT
      <213> Homo sapiens


      <400> 707
 Met Glu Ala Glu Leu Glu Asn Phe His Lys Gln Asn Thr Gln Leu Glu
   1               5                  10                  15    
 Leu Asn Ile Thr Glu Leu Trp Gln Lys Leu Arg Ala Thr Asp Gln Glu
              20                  25                  30        
 Met Arg Arg Glu Arg Gln Lys Glu Arg Asp Leu Glu Ala Leu Val Lys
          35                  40                  45            
 Arg Phe Lys Thr Asp Leu His Asn Cys Val Ala Tyr Ile Gln Glu Pro
      50                  55                  60                
 Arg Leu Leu Lys Glu Lys Val Arg Gly Leu Phe Glu Lys Tyr Val Gln
  65                  70                  75                  80
 Arg Ala Asp Met Val Glu Ile Ala Gly Leu Asn Thr Asp Leu Gln Gln
                  85                  90                  95    
 Glu Tyr Thr Arg Gln Arg Glu His Leu Glu Arg Asn Leu Ala Thr Leu
             100                 105                 110        
 Lys Lys Lys Val Val Lys Glu Gly Glu Leu His Arg Thr Asp Tyr Val
         115                 120                 125            
 Arg Ile Met Gln Glu Asn Val Ser Leu Ile Lys Glu Ile Asn Glu Leu
     130                 135                 140                
 Arg Arg Glu Leu Lys Phe Thr Arg Ser Gln Val Tyr Asp Leu Glu Ala
 145                 150                 155                 160
 Ala Leu Lys Leu Thr Lys Lys Val Arg Pro Gln Glu Val Ser Glu Thr
                 165                 170                 175    
 Glu Pro Ser Arg Asp Met Leu Ser Thr Ala Pro Thr Ala Arg Leu Asn
             180                 185                 190        
 Glu Gln Glu Glu Thr Gly Arg Ile Ile Glu Met Gln Arg Leu Glu Ile
         195                 200                 205            
 Gln Arg Leu Arg Asp Gln Ile Gln Glu Gln Glu Gln Val Thr Gly Phe
     210                 215                 220                
 His Thr Leu Ala Gly Val Arg Leu Pro Ser Leu Ser Asn Ser Glu Val
 225                 230                 235                 240
 Asp Leu Glu Val Lys Thr Asn
                 245        



      <210> 708
      <211> 227
      <212> PRT
      <213> Homo sapiens


      <400> 708
 Met Thr Asp Phe Lys Leu Gly Ile Val Arg Leu Gly Arg Val Ala Gly
   1               5                  10                  15    
 Lys Thr Lys Tyr Thr Leu Ile Asp Glu Gln Asp Ile Pro Leu Val Glu
              20                  25                  30        
 Ser Tyr Ser Phe Glu Ala Arg Met Glu Val Asp Ala Asp Gly Asn Gly
          35                  40                  45            
 Ala Lys Ile Phe Ala Tyr Ala Phe Asp Lys Asn Arg Gly Arg Gly Ser
      50                  55                  60                
 Gly Arg Leu Leu His Glu Leu Leu Trp Glu Arg His Arg Gly Gly Val
  65                  70                  75                  80
 Ala Pro Gly Phe Gln Val Val His Leu Asn Ala Val Thr Val Asp Asn
                  85                  90                  95    
 Arg Leu Asp Asn Leu Gln Leu Val Pro Trp Gly Trp Arg Pro Lys Ala
             100                 105                 110        
 Glu Glu Thr Ser Ser Lys Gln Arg Glu Gln Ser Leu Tyr Trp Leu Ala
         115                 120                 125            
 Ile Gln Gln Leu Pro Thr Asp Pro Ile Glu Glu Gln Phe Pro Val Leu
     130                 135                 140                
 Asn Val Thr Arg Tyr Tyr Asn Ala Asn Gly Asp Val Val Glu Glu Glu
 145                 150                 155                 160
 Glu Asn Ser Cys Thr Tyr Tyr Glu Cys His Tyr Pro Pro Cys Thr Val
                 165                 170                 175    
 Ile Glu Lys Gln Leu Arg Glu Phe Asn Ile Cys Gly Arg Cys Gln Val
             180                 185                 190        
 Ala Arg Tyr Cys Gly Ser Gln Cys Gln Gln Lys Asp Trp Pro Ala His
         195                 200                 205            
 Lys Lys His Cys Arg Glu Arg Lys Arg Pro Phe Gln His Glu Leu Glu
     210                 215                 220                
 Pro Glu Arg
 225        



      <210> 709
      <211> 123
      <212> PRT
      <213> Homo sapiens


      <400> 709
 Met Ala Pro Gly Ala Gly Glu His His Leu Ala Arg Arg Val Arg Ser
   1               5                  10                  15    
 Asp Pro Gly Gly Gly Gly Leu Ala Tyr Ala Ala Tyr Ala Asn Gly Leu
              20                  25                  30        
 Gly Ala Gln Leu Pro Gly Leu Gln Pro Ser Asp Thr Ser Gly Ser Ser
          35                  40                  45            
 Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Gly Leu
      50                  55                  60                
 Arg Arg Lys Gly Ser Arg Asp Cys Ser Val Cys Phe Glu Ser Glu Val
  65                  70                  75                  80
 Ile Ala Ala Leu Val Pro Cys Gly His Asn Leu Phe Cys Met Glu Cys
                  85                  90                  95    
 Ala Asn Arg Ile Cys Glu Lys Ser Glu Pro Glu Cys Pro Val Cys His
             100                 105                 110        
 Thr Ala Val Thr Gln Ala Ile Arg Ile Phe Ser
         115                 120            



      <210> 710
      <211> 132
      <212> PRT
      <213> Homo sapiens


      <400> 710
 Met Ile Arg Glu Phe Trp Arg Asn Tyr Ser Ile Met Asp Ala Val Asp
   1               5                  10                  15    
 Met Ala Ile Ala Trp Glu Glu Leu Lys Pro Ala Leu Met Asn Ser Met
              20                  25                  30        
 Trp Lys Lys Ile Trp Pro Glu Cys Val Gln Ala Gln Arg Phe Ser Gln
          35                  40                  45            
 Ala Asp Asn Ile Ala Gln Leu Gln Lys Asn Ile Val Thr Leu Ala Arg
      50                  55                  60                
 Asn Val Ala Phe Glu Glu Val Ala Glu Ala Ala Val Asp Gln Leu Leu
  65                  70                  75                  80
 Gln Ser His Glu Glu Asp Leu Ser Asn Glu Glu Leu Met Arg Leu Glu
                  85                  90                  95    
 Gln Glu Leu Ala Val Gly Glu Glu Glu Arg Glu Asp Gly Pro Trp Ala
             100                 105                 110        
 Leu Trp Gln Leu Thr Thr Gly Arg Leu Ser Ala Ala Leu Ser His Phe
         115                 120                 125            
 Glu Ala Gly Leu
     130        



      <210> 711
      <211> 154
      <212> PRT
      <213> Homo sapiens


      <400> 711
 Met His Val Thr Glu Ala Leu His Gln Asn Met Gln Ala Leu Phe Ser
   1               5                  10                  15    
 Thr Leu Ala Gln Ala Glu Glu Gln Gln Pro Tyr Leu Glu Gly Ser Thr
              20                  25                  30        
 Val Met Arg Gly Thr Arg Cys Leu Ala Glu Tyr His Leu Gly Asp Tyr
          35                  40                  45            
 Gly His Ala Trp Asn Arg Cys Trp Val Leu Asp Arg Val Asp Thr Trp
      50                  55                  60                
 Ala Val Val Met Phe Ile Asp Phe Gly Gln Leu Ala Thr Ile Pro Val
  65                  70                  75                  80
 Gln Ser Leu Arg Ser Leu Asp Ser Asp Asp Phe Trp Thr Ile Pro Pro
                  85                  90                  95    
 Leu Thr Gln Pro Phe Met Leu Glu Lys Asp Ile Leu Ser Ser Tyr Glu
             100                 105                 110        
 Val Val His Arg Ile Leu Lys Gly Lys Ile Thr Gly Ala Leu Asn Ser
         115                 120                 125            
 Ala Val Thr Ala Pro Ala Ser Asn Leu Ala Val Val Pro Pro Leu Leu
     130                 135                 140                
 Pro Leu Gly Cys Leu Gln Gln Ala Ala Ala
 145                 150                



      <210> 712
      <211> 604
      <212> PRT
      <213> Homo sapiens


      <400> 712
 Met Ile Asn Met Asp Gln Ser Ala Ala Leu Glu Pro Glu Ala Pro Pro
   1               5                  10                  15    
 Arg Leu Leu Ala Pro Arg Ala Arg Gly Gly Pro Pro Gly Asp Gly Ser
              20                  25                  30        
 Glu Leu Asp Pro Asp Val Leu Gln Arg Pro Glu Arg Ala Arg Leu Ser
          35                  40                  45            
 Glu Asn Thr Arg Leu Ala Thr Arg Tyr Ala Val Arg Ile Phe Arg Glu
      50                  55                  60                
 Tyr Leu Ser Glu Lys Ala Gln Ser Pro Asp Phe Glu Thr Met Asp Lys
  65                  70                  75                  80
 Gly Ala Leu Cys Arg Val Leu Arg Ser Phe Tyr Ala Glu Ala Arg Ser
                  85                  90                  95    
 Lys Ser Gly Gln Leu Tyr Ser Lys Ser Ser Leu Ile Ser Ile Arg Ser
             100                 105                 110        
 Ser Leu Asn Arg Tyr Leu Asn Glu Pro Pro Tyr Cys Arg Thr Leu Asp
         115                 120                 125            
 Leu Thr Lys Asp Pro Glu Leu Arg Ser Ala Asn Leu Thr Leu Ala Ala
     130                 135                 140                
 Val Ile Arg Lys Leu Glu Glu Gln Gly Ala Gly Pro Val Val Gln Lys
 145                 150                 155                 160
 Gln Ala Ile Thr Arg Ala Asp Leu Arg Lys Leu Tyr Thr Ser Ser Val
                 165                 170                 175    
 Phe Ser Thr Asn Thr Pro Phe Gly Leu Leu Asn Lys Val Trp Phe Glu
             180                 185                 190        
 Thr Cys Met Tyr Phe Cys Thr Arg Gly Arg Glu Asn Gln Arg Glu Leu
         195                 200                 205            
 Glu Glu Asp Ser Phe Gly Leu Ala Met Asp Glu Asp Gly Arg Lys Phe
     210                 215                 220                
 Val Tyr Phe Lys Ser Leu Gly Pro Tyr His Lys Ser Arg Ser Ser Ser
 225                 230                 235                 240
 Trp Ser Lys Lys Arg Ala Glu Ser Ser Asp Glu Glu Asn Leu Pro Arg
                 245                 250                 255    
 Met Tyr Glu Thr Gly Thr Glu Phe Cys Pro Tyr Ala Ser Phe Val Lys
             260                 265                 270        
 Tyr Leu Ser Lys Arg Asn Pro Leu Cys Lys Ala Phe Phe Gln Arg Pro
         275                 280                 285            
 Arg Asp His Cys Ser Glu Gly Asp Val Thr Trp Tyr Glu Asn Lys Ala
     290                 295                 300                
 Ile Gly Lys Asn Leu Leu Gly Thr Arg Met Gln Met Leu Ser Lys Ala
 305                 310                 315                 320
 Ala Lys Leu Ser Lys Thr Tyr Thr Asn His Cys Ile Gly Ala Val Ser
                 325                 330                 335    
 Ile Ala Thr Leu Asn Ser Ile Ala Gly Ile Gly Thr Lys Leu Gly Ser
             340                 345                 350        
 Pro Ala Pro Gln Gly Cys Tyr Ala Glu Ala Leu Asn Gly Ala Ala Arg
         355                 360                 365            
 His His Ser His His Pro Pro Thr His Pro Ser His His His Arg Pro
     370                 375                 380                
 Gln Pro Pro Ser Leu Gly Asn Thr Tyr Ile Leu Pro Lys Asp Ser Gln
 385                 390                 395                 400
 Val Gly Pro Asp Val Lys Ser Glu Ala Ala Pro Lys Arg Ala Leu Tyr
                 405                 410                 415    
 Glu Ser Val Phe Gly Ser Gly Glu Ile Cys Gly Pro Thr Ser Pro Lys
             420                 425                 430        
 Arg Leu Cys Ile Arg Pro Ser Glu Pro Val Asp Ala Val Val Val Val
         435                 440                 445            
 Ser Val Lys His Asp Pro Leu Pro Leu Leu Pro Glu Ala Asn Gly His
     450                 455                 460                
 Arg Ser Thr Asn Ser Pro Thr Ile Val Ser Pro Ala Ile Val Ser Pro
 465                 470                 475                 480
 Thr Gln Asp Ser Arg Pro Asn Met Ser Arg Pro Leu Ile Thr Arg Ser
                 485                 490                 495    
 Pro Ala Ser Pro Leu Asn Asn Gln Gly Ile Pro Thr Pro Ala Gln Leu
             500                 505                 510        
 Thr Lys Ser Asn Ala Pro Val His Ile Asp Val Gly Gly His Met Tyr
         515                 520                 525            
 Thr Ser Ser Leu Ala Thr Leu Thr Lys Tyr Pro Glu Ser Arg Ile Gly
     530                 535                 540                
 Arg Leu Phe Asp Gly Thr Glu Pro Ile Val Leu Asp Ser Leu Lys Gln
 545                 550                 555                 560
 His Tyr Phe Ile Asp Arg Asp Gly Gln Met Phe Arg Tyr Ile Leu Asn
                 565                 570                 575    
 Phe Leu Arg Thr Ser Lys Leu Leu Ile Pro Asp Asp Phe Lys Asp Tyr
             580                 585                 590        
 Thr Leu Leu Tyr Glu Glu Ala Lys Tyr Phe Gln Leu
         595                 600                



      <210> 713
      <211> 770
      <212> PRT
      <213> Homo sapiens


      <400> 713
 Met Phe Met Gly Ala Gly Asp Ala Pro Leu Gly Ser Arg Pro Gly His
   1               5                  10                  15    
 Pro His Ser Ser Ser Gln Val Lys Ser Lys Leu Gln Ile Gly Pro Pro
              20                  25                  30        
 Ser Pro Gly Glu Ala Gln Gly Pro Leu Leu Pro Ser Pro Ala Arg Gly
          35                  40                  45            
 Leu Lys Phe Leu Lys Leu Pro Pro Thr Ser Glu Lys Ser Pro Ser Pro
      50                  55                  60                
 Gly Gly Pro Gln Leu Ser Pro Gln Leu Pro Arg Asn Ser Arg Ile Pro
  65                  70                  75                  80
 Cys Arg Asn Ser Gly Ser Asp Gly Ser Pro Ser Pro Leu Leu Ala Arg
                  85                  90                  95    
 Arg Gly Leu Gly Gly Gly Glu Leu Ser Pro Glu Gly Ala Gln Gly Leu
             100                 105                 110        
 Pro Thr Ser Pro Ser Pro Cys Tyr Thr Thr Pro Asp Ser Thr Gln Leu
         115                 120                 125            
 Arg Pro Pro Gln Ser Ala Leu Ser Thr Thr Leu Ser Pro Gly Pro Val
     130                 135                 140                
 Val Ser Pro Cys Tyr Glu Asn Ile Leu Asp Leu Ser Arg Ser Thr Phe
 145                 150                 155                 160
 Arg Gly Pro Ser Pro Glu Pro Pro Pro Ser Pro Leu Gln Val Pro Thr
                 165                 170                 175    
 Tyr Pro Gln Leu Thr Leu Glu Val Pro Gln Ala Pro Glu Val Leu Arg
             180                 185                 190        
 Ser Pro Gly Val Pro Pro Ser Pro Cys Leu Pro Glu Ser Tyr Pro Tyr
         195                 200                 205            
 Gly Ser Pro Gln Glu Lys Ser Leu Asp Lys Ala Gly Ser Glu Ser Pro
     210                 215                 220                
 His Pro Gly Arg Arg Thr Pro Gly Asn Ser Ser Lys Lys Pro Ser Gln
 225                 230                 235                 240
 Gly Ser Gly Arg Arg Pro Gly Asp Pro Gly Ser Thr Pro Leu Arg Asp
                 245                 250                 255    
 Arg Leu Ala Ala Leu Gly Lys Leu Lys Thr Gly Pro Glu Gly Ala Leu
             260                 265                 270        
 Gly Ser Glu Lys Asn Gly Val Pro Ala Arg Pro Gly Ile Glu Lys Thr
         275                 280                 285            
 Arg Gly Pro Gly Lys Ser Gly Glu Ser Ala Gly Asp Met Val Pro Ser
     290                 295                 300                
 Ile His Arg Pro Leu Glu Gln Leu Glu Ala Lys Gly Gly Ile Arg Gly
 305                 310                 315                 320
 Ala Val Ala Leu Gly Thr Asn Ser Leu Lys Gln Gln Glu Pro Gly Leu
                 325                 330                 335    
 Met Gly Asp Pro Gly Ala Arg Val Tyr Ser Ser His Ser Met Gly Ala
             340                 345                 350        
 Arg Val Asp Leu Glu Pro Val Ser Pro Arg Ser Cys Leu Thr Lys Val
         355                 360                 365            
 Glu Leu Ala Lys Ser Arg Leu Ala Gly Ala Leu Cys Pro Gln Ser Thr
     370                 375                 380                
 Pro Leu Val Pro Gly Pro Thr Asp Pro Ser Gln Gly Pro Glu Gly Leu
 385                 390                 395                 400
 Ala Pro His Ser Ala Ile Glu Glu Lys Val Met Lys Gly Ile Glu Glu
                 405                 410                 415    
 Asn Val Leu Arg Leu Gln Gly Gln Glu Arg Ala Pro Gly Ala Glu Val
             420                 425                 430        
 Lys His Arg Asn Thr Ser Ser Ile Ala Ser Trp Phe Gly Leu Lys Lys
         435                 440                 445            
 Ser Lys Leu Pro Ala Leu Asn Arg Arg Thr Glu Ala Thr Lys Asn Lys
     450                 455                 460                
 Glu Gly Ala Gly Gly Gly Ser Pro Leu Arg Arg Glu Val Lys Met Glu
 465                 470                 475                 480
 Ala Arg Lys Leu Glu Ala Glu Ser Leu Asn Ile Ser Lys Leu Met Ala
                 485                 490                 495    
 Lys Ala Glu Asp Leu Arg Arg Ala Leu Glu Glu Glu Lys Ala Tyr Leu
             500                 505                 510        
 Ser Ser Arg Ala Arg Gln Arg Leu Val Pro Ser Pro Arg Ala Gln His
         515                 520                 525            
 Gly Ala Gly Ala Gly Ala Gly Pro Ala Gly Trp His Val Pro Arg Cys
     530                 535                 540                
 Arg His Leu His Ala Ala Ala Ala Lys Gln Glu Arg Asp Lys Gly Ser
 545                 550                 555                 560
 Pro Leu Pro Ile Leu Pro Phe Asp Ile Cys His Asn Arg Ser Cys Gly
                 565                 570                 575    
 Leu Lys Lys Gly Ser Thr His Leu Gly Val Ala Leu Ser Gly Pro Asp
             580                 585                 590        
 Glu Ala Glu Ser Leu Gln Glu Leu Gly Pro Arg Val Asp Gly Lys Glu
         595                 600                 605            
 Leu Pro Ser Lys Ser Trp Arg Glu Pro Lys Pro Glu Tyr Gly Asp Phe
     610                 615                 620                
 Gln Pro Val Ser Ser Asp Pro Lys Ser Pro Trp Pro Ala Cys Gly Pro
 625                 630                 635                 640
 Arg Asn Gly Leu Val Gly Pro Leu Gln Gly Cys Gly Lys Pro Pro Gly
                 645                 650                 655    
 Lys Gln Val Pro Gly Ser Val Cys His Leu Gly Ala Lys His Gln Val
             660                 665                 670        
 Gly Thr Gly Ala Thr Gln Glu Gln Ile Leu Pro Cys Pro Gln Gly Thr
         675                 680                 685            
 Arg Pro Thr Tyr Thr Pro Ser Pro Ser Pro Gly Gln Ala Leu Pro Val
     690                 695                 700                
 Asp Arg Lys Arg Ser Gln Glu Pro Ser Arg Pro Ser Pro Thr Pro Gln
 705                 710                 715                 720
 Gly Pro Pro Phe Gly Gly Ser Arg Thr Pro Ser Thr Ser Asp Met Ala
                 725                 730                 735    
 Glu Glu Gly Arg Val Ala Ser Gly Gly Pro Pro Gly Leu Glu Thr Ser
             740                 745                 750        
 Glu Ser Leu Ser Asp Ser Leu Tyr Asp Ser Leu Ser Ser Cys Gly Ser
         755                 760                 765            
 Gln Gly
     770



      <210> 714
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 714
 Met Gln Ser Gln Pro Gly Trp Glu Ala Val Gln Thr Ala Pro Asp Leu
   1               5                  10                  15    
 Gly Arg Asp Gly Lys Leu Asn Arg Leu Val Gln Ile Leu Ala Arg Ser
              20                  25                  30        
 Pro Glu Ala Pro Gly Thr Pro Arg Pro Val Ser Pro Trp Pro His Gln
          35                  40                  45            
 Tyr Pro Thr Ser Lys Cys Pro Val Gly Asp His Gln Ala Thr Gln Ala
      50                  55                  60                
 Arg Leu Arg Gly His Arg Leu Cys Thr Met Gly Arg Arg Pro Val Pro
  65                  70                  75                  80
 Ala Ser Leu Arg Cys Pro Leu Val Ser Gly Ala Pro Asp Ser Ser Phe
                  85                  90                  95    
 Leu Arg Ala Cys Val Ala Ser Cys Leu Ala Ser His Leu Gln Leu Ser
             100                 105                 110        
 Gly Ser Ser Thr Gly Pro Ser Gly Gly
         115                 120    



      <210> 715
      <211> 470
      <212> PRT
      <213> Homo sapiens


      <400> 715
 Met Gln Lys Gly Lys Gly Arg Thr Ser Arg Ile Arg Arg Arg Lys Leu
   1               5                  10                  15    
 Cys Gly Ser Ser Glu Ser Glu Lys Arg Asn Tyr Ser Phe Ser Met Gln
              20                  25                  30        
 Lys Gly Lys Gly Arg Thr Ser Arg Ile Arg Arg Arg Lys Leu Cys Gly
          35                  40                  45            
 Ser Ser Glu Ser Arg Gly Val Asn Glu Ser His Lys Ser Glu Phe Ile
      50                  55                  60                
 Glu Leu Arg Lys Trp Leu Lys Ala Arg Lys Phe Gln Asp Ser Asn Leu
  65                  70                  75                  80
 Ala Pro Ala Cys Phe Pro Gly Thr Gly Arg Gly Leu Met Ser Gln Thr
                  85                  90                  95    
 Ser Leu Gln Glu Gly Gln Met Ile Ile Ser Leu Pro Glu Ser Cys Leu
             100                 105                 110        
 Leu Thr Thr Asp Thr Val Ile Arg Ser Tyr Leu Gly Ala Tyr Ile Thr
         115                 120                 125            
 Lys Trp Lys Pro Pro Pro Ser Pro Leu Leu Ala Leu Cys Thr Phe Leu
     130                 135                 140                
 Val Ser Glu Lys His Ala Gly His Arg Ser Leu Trp Lys Pro Tyr Leu
 145                 150                 155                 160
 Glu Ile Leu Pro Lys Ala Tyr Thr Cys Pro Val Cys Leu Glu Pro Glu
                 165                 170                 175    
 Val Val Asn Leu Leu Pro Lys Ser Leu Lys Ala Lys Ala Glu Glu Gln
             180                 185                 190        
 Arg Ala His Val Gln Glu Phe Phe Ala Ser Ser Arg Asp Phe Phe Ser
         195                 200                 205            
 Ser Leu Gln Pro Leu Phe Ala Glu Ala Val Asp Ser Ile Phe Ser Tyr
     210                 215                 220                
 Ser Ala Leu Leu Trp Ala Trp Cys Thr Val Asn Thr Arg Ala Val Tyr
 225                 230                 235                 240
 Leu Arg Pro Arg Gln Arg Glu Cys Leu Ser Ala Glu Pro Asp Thr Cys
                 245                 250                 255    
 Ala Leu Ala Pro Tyr Leu Asp Leu Leu Asn His Ser Pro His Val Gln
             260                 265                 270        
 Val Lys Ala Ala Phe Asn Glu Glu Thr His Ser Tyr Glu Ile Arg Thr
         275                 280                 285            
 Thr Ser Arg Trp Arg Lys His Glu Glu Val Phe Ile Cys Tyr Gly Pro
     290                 295                 300                
 His Asp Asn Gln Arg Leu Phe Leu Glu Tyr Gly Phe Val Ser Val His
 305                 310                 315                 320
 Asn Pro His Ala Cys Val Tyr Val Ser Arg Glu Ile Leu Val Lys Tyr
                 325                 330                 335    
 Leu Pro Ser Thr Asp Lys Gln Met Asp Lys Lys Ile Ser Ile Leu Lys
             340                 345                 350        
 Asp His Gly Tyr Ile Glu Asn Leu Thr Phe Gly Trp Asp Gly Pro Ser
         355                 360                 365            
 Trp Arg Leu Leu Thr Ala Leu Lys Leu Leu Cys Leu Glu Ala Glu Lys
     370                 375                 380                
 Phe Thr Cys Trp Lys Lys Val Leu Leu Gly Glu Val Ile Ser Asp Thr
 385                 390                 395                 400
 Asn Glu Lys Thr Ser Leu Asp Ile Ala Gln Lys Ile Cys Tyr Tyr Phe
                 405                 410                 415    
 Ile Glu Glu Thr Asn Ala Val Leu Gln Lys Val Ser His Met Lys Asp
             420                 425                 430        
 Glu Lys Glu Ala Leu Ile Asn Gln Leu Thr Leu Val Glu Ser Leu Trp
         435                 440                 445            
 Thr Glu Glu Leu Lys Ile Leu Arg Ala Ser Ala Glu Thr Leu His Ser
     450                 455                 460                
 Leu Gln Thr Ala Phe Thr
 465                 470



      <210> 716
      <211> 455
      <212> PRT
      <213> Homo sapiens


      <400> 716
 Met Ser Gly Lys Val Lys Asp Gly Thr Pro Cys Ser Pro Asn Lys Asn
   1               5                  10                  15    
 Asp Val Cys Ile Asp Gly Val Cys Glu Leu Val Gly Cys Asp His Glu
              20                  25                  30        
 Leu Gly Ser Lys Ala Val Ser Asp Ala Cys Gly Val Cys Lys Gly Asp
          35                  40                  45            
 Asn Ser Thr Cys Lys Phe Tyr Lys Gly Leu Tyr Leu Asn Gln His Lys
      50                  55                  60                
 Ala Asn Glu Tyr Tyr Pro Val Val Leu Ile Pro Ala Gly Ala Arg Ser
  65                  70                  75                  80
 Ile Glu Ile Gln Glu Leu Gln Val Ser Ser Ser Tyr Leu Ala Val Arg
                  85                  90                  95    
 Ser Leu Ser Gln Lys Tyr Tyr Leu Thr Gly Gly Trp Ser Ile Asp Trp
             100                 105                 110        
 Pro Gly Glu Phe Pro Phe Ala Gly Thr Thr Phe Glu Tyr Gln Arg Ser
         115                 120                 125            
 Phe Asn Arg Pro Glu Arg Leu Tyr Ala Pro Gly Pro Thr Asn Glu Thr
     130                 135                 140                
 Leu Val Phe Glu Val Met Pro Leu Leu Cys Ile Gln Phe Ser Val Leu
 145                 150                 155                 160
 Leu Ala Thr Phe Ile Ser Tyr Asp Trp Met Pro Gly Glu Trp Ser Thr
                 165                 170                 175    
 Cys Ser Lys Ala Cys Ala Gly Gly Gln Gln Ser Arg Lys Ile Gln Cys
             180                 185                 190        
 Val Gln Lys Lys Pro Phe Gln Lys Glu Glu Ala Val Leu His Ser Leu
         195                 200                 205            
 Cys Pro Val Ser Thr Pro Thr Gln Val Gln Ala Cys Asn Ser His Ala
     210                 215                 220                
 Cys Pro Pro Gln Trp Ser Leu Gly Pro Trp Ser Gln Cys Ser Lys Thr
 225                 230                 235                 240
 Cys Gly Arg Gly Val Arg Lys Arg Glu Leu Leu Cys Lys Gly Ser Ala
                 245                 250                 255    
 Ala Glu Thr Leu Pro Glu Ser Gln Cys Thr Ser Leu Pro Arg Pro Glu
             260                 265                 270        
 Leu Gln Glu Gly Cys Val Leu Gly Arg Cys Pro Lys Asn Ser Arg Leu
         275                 280                 285            
 Gln Trp Val Ala Ser Ser Trp Ser Glu Cys Ser Ala Thr Cys Gly Leu
     290                 295                 300                
 Gly Val Arg Lys Arg Glu Met Lys Cys Ser Glu Lys Gly Phe Gln Gly
 305                 310                 315                 320
 Lys Leu Ile Thr Phe Pro Glu Arg Arg Cys Arg Asn Ile Lys Lys Pro
                 325                 330                 335    
 Asn Leu Asp Leu Glu Glu Thr Cys Asn Arg Arg Ala Cys Pro Ala His
             340                 345                 350        
 Pro Val Tyr Asn Met Val Ala Gly Trp Tyr Ser Leu Pro Trp Gln Gln
         355                 360                 365            
 Cys Thr Val Thr Cys Gly Gly Gly Val Gln Thr Arg Ser Val His Cys
     370                 375                 380                
 Val Gln Gln Gly Arg Pro Ser Ser Ser Cys Leu Leu His Gln Lys Pro
 385                 390                 395                 400
 Pro Val Leu Arg Ala Cys Asn Thr Asn Phe Cys Pro Ala Pro Glu Lys
                 405                 410                 415    
 Arg Glu Asp Pro Ser Cys Val Asp Phe Phe Asn Trp Cys His Leu Val
             420                 425                 430        
 Pro Gln His Gly Val Cys Asn His Lys Phe Tyr Gly Lys Gln Cys Cys
         435                 440                 445            
 Lys Ser Cys Thr Arg Lys Ile
     450                 455



      <210> 717
      <211> 231
      <212> PRT
      <213> Homo sapiens


      <400> 717
 Met Gly Val Asp Ile Arg His Asn Lys Asp Arg Lys Val Arg Arg Lys
   1               5                  10                  15    
 Glu Pro Lys Ser Gln Asp Ile Tyr Leu Arg Leu Leu Val Lys Leu Tyr
              20                  25                  30        
 Arg Phe Leu Ala Arg Arg Thr Asn Ser Thr Phe Asn Gln Val Val Leu
          35                  40                  45            
 Lys Arg Leu Phe Met Ser Arg Thr Asn Arg Pro Pro Leu Ser Leu Ser
      50                  55                  60                
 Arg Met Ile Arg Lys Met Lys Leu Pro Gly Arg Glu Asn Lys Thr Ala
  65                  70                  75                  80
 Val Val Val Gly Thr Ile Thr Asp Asp Val Arg Val Gln Glu Val Pro
                  85                  90                  95    
 Lys Leu Lys His Asn Thr Arg Asp Val Val Val Lys Val Pro Glu Val
             100                 105                 110        
 Leu Arg Thr Ala Ala Val Ser Pro Gly Val Leu Arg Val Val Asn Asp
         115                 120                 125            
 Ser Val Gly Tyr Gln Gly Ser Ala Ala Pro Arg Gln Trp Arg Val Cys
     130                 135                 140                
 Ala Leu Arg Val Thr Ser Arg Ala Arg Ser Arg Ile Leu Arg Ala Gly
 145                 150                 155                 160
 Gly Lys Ile Leu Thr Phe Asp Gln Leu Ala Leu Asp Ser Pro Lys Gly
                 165                 170                 175    
 Cys Gly Thr Val Leu Leu Ser Gly Pro Arg Lys Gly Arg Glu Val Tyr
             180                 185                 190        
 Arg His Phe Gly Lys Ala Pro Gly Thr Pro His Ser His Thr Lys Pro
         195                 200                 205            
 Tyr Val Arg Ser Lys Gly Arg Lys Phe Glu Arg Ala Arg Gly Arg Arg
     210                 215                 220                
 Ala Ser Arg Gly Tyr Lys Asn
 225                 230    



      <210> 718
      <211> 103
      <212> PRT
      <213> Homo sapiens


      <400> 718
 Met Leu Asp Ala Ile Met Lys Ala Asp Ala Gly Leu His Gly Glu Gly
   1               5                  10                  15    
 His Gln Glu Gly Trp Glu Glu Gly Arg Ser Val Gly Val Thr Glu Gly
              20                  25                  30        
 Arg Gln His Arg Arg Val His Gly Ala Asn Ile Arg Pro Glu Ile Arg
          35                  40                  45            
 Cys Tyr Gln Gly Phe Ala Phe Ala Trp Gly Cys Leu Leu His Ser Trp
      50                  55                  60                
 Ala Thr Gln Lys Asp Arg Arg Lys Met Trp Phe Leu Glu Ser Leu Ile
  65                  70                  75                  80
 Gly Met Ile Gln Lys Phe Leu Tyr Glu Asp Pro Ala Tyr Asp Glu Leu
                  85                  90                  95    
 His Glu Asp Leu Glu Glu Asn
             100            



      <210> 719
      <211> 53
      <212> PRT
      <213> Homo sapiens


      <400> 719
 Met Gly Lys His Leu Gly Lys Gln Gln His Leu Val Leu Val Pro Glu
   1               5                  10                  15    
 Glu Ser Ser Asp His Val Ala Trp Arg Ile Leu Gly Tyr Arg Asp Pro
              20                  25                  30        
 Asp Ala Gly Ser Arg Thr Pro Arg Met Ser Glu Val Ser Thr His Val
          35                  40                  45            
 Pro Arg Lys Asp Lys
      50            



      <210> 720
      <211> 281
      <212> PRT
      <213> Homo sapiens


      <400> 720
 Met Leu Ser Ala Ala Pro Glu Pro Pro Pro Arg Pro Pro Pro Ala Leu
   1               5                  10                  15    
 Ser Pro Pro Gly Ser Gly Pro Gly Ser Gly Ser Arg His Gly Ser Ala
              20                  25                  30        
 Arg Pro Gly Pro Thr Pro Glu Pro Ser Gly Ser Leu Gly Ala Ala Leu
          35                  40                  45            
 Asp Ser Ser Leu Arg Ala Ala Val Ala Phe Lys Ala Glu Gly Gln Arg
      50                  55                  60                
 Cys Tyr Arg Glu Lys Lys Phe Arg Glu Ala Ile Gly Lys Tyr His Arg
  65                  70                  75                  80
 Ala Leu Leu Gln Leu Lys Ala Ala Gln Gly Ala Arg Pro Ser Gly Leu
                  85                  90                  95    
 Pro Ala Pro Ala Pro Gly Pro Thr Ser Ser Pro Gly Pro Ala Arg Leu
             100                 105                 110        
 Ser Glu Glu Gln Arg Arg Leu Val Glu Ser Thr Glu Val Glu Cys Tyr
         115                 120                 125            
 Asp Ser Leu Thr Gly Thr Pro Ser Gly Gly Glu Arg Ile Gly Ala Pro
     130                 135                 140                
 Gly Cys Arg Ser Asn Pro Leu Gly Leu Val Pro Cys Arg Leu Glu Pro
 145                 150                 155                 160
 Arg Leu Leu Ala Val Arg Trp Val Leu Gly Val Pro Ala Gly Ser Glu
                 165                 170                 175    
 Ser Ala Gly Arg Gly Ala Leu Ala Ala Cys Leu Leu Gln Ser Glu Leu
             180                 185                 190        
 Val Asn Tyr Glu Arg Val Arg Glu Tyr Cys Leu Lys Val Leu Glu Lys
         195                 200                 205            
 Gln Gln Gly Asn Phe Lys Ala Thr Tyr Arg Ala Gly Ile Ala Phe Tyr
     210                 215                 220                
 His Leu Gly Asp Tyr Ala Arg Ala Leu Arg Tyr Leu Gln Glu Ala Arg
 225                 230                 235                 240
 Ser Arg Glu Pro Thr Asp Thr Asn Val Leu Arg Tyr Ile Gln Leu Thr
                 245                 250                 255    
 Gln Leu Lys Met Asn Arg Cys Ser Leu Gln Arg Glu Asp Ser Gly Ala
             260                 265                 270        
 Gly Ser Gln Thr Arg Asp Val Ile Gly
         275                 280    



      <210> 721
      <211> 462
      <212> PRT
      <213> Homo sapiens


      <400> 721
 Met Gly Pro Asp Arg Val Thr Ala Arg Glu Leu Cys Glu Asn Asp Asp
   1               5                  10                  15    
 Leu Ala Thr Ser Leu Val Leu Asp Pro Tyr Leu Gly Phe Arg Thr His
              20                  25                  30        
 Lys Met Asn Val Ser Pro Val Pro Pro Leu Arg Arg Gln Gln His Leu
          35                  40                  45            
 Arg Ser Ala Leu Glu Thr Phe Leu Arg Gln Arg Asp Leu Glu Ala Ala
      50                  55                  60                
 Tyr Arg Ala Leu Thr Leu Gly Gly Trp Thr Ala Arg Tyr Phe Gln Ser
  65                  70                  75                  80
 Arg Gly Pro Arg Gln Glu Ala Ala Leu Lys Thr His Val Tyr Arg Tyr
                  85                  90                  95    
 Leu Arg Ala Phe Leu Pro Glu Ser Gly Phe Thr Ile Leu Pro Cys Thr
             100                 105                 110        
 Arg Tyr Ser Met Glu Thr Asn Gly Ala Lys Ile Val Ser Thr Arg Ala
         115                 120                 125            
 Trp Lys Lys Asn Glu Lys Leu Glu Leu Leu Val Gly Cys Ile Ala Glu
     130                 135                 140                
 Leu Arg Glu Ala Asp Glu Gly Leu Leu Arg Ala Gly Glu Asn Asp Phe
 145                 150                 155                 160
 Ser Ile Met Tyr Ser Thr Arg Lys Arg Ser Ala Gln Leu Trp Leu Gly
                 165                 170                 175    
 Pro Ala Ala Phe Ile Asn His Asp Cys Lys Pro Asn Cys Lys Phe Val
             180                 185                 190        
 Pro Ala Asp Gly Asn Ala Ala Cys Val Lys Val Leu Arg Asp Ile Glu
         195                 200                 205            
 Pro Gly Asp Glu Val Thr Cys Phe Tyr Gly Glu Gly Phe Phe Gly Glu
     210                 215                 220                
 Lys Asn Glu His Cys Glu Cys His Thr Cys Glu Arg Lys Gly Glu Gly
 225                 230                 235                 240
 Ala Phe Arg Thr Arg Pro Arg Glu Pro Ala Leu Pro Pro Arg Pro Leu
                 245                 250                 255    
 Asp Lys Tyr Gln Leu Arg Glu Thr Lys Arg Arg Leu Gln Gln Gly Leu
             260                 265                 270        
 Asp Ser Gly Ser Arg Gln Gly Leu Leu Gly Pro Arg Ala Cys Val His
         275                 280                 285            
 Pro Ser Pro Leu Arg Arg Asp Pro Phe Cys Ala Ala Cys Gln Pro Leu
     290                 295                 300                
 Arg Leu Pro Ala Cys Ser Ala Arg Pro Asp Thr Ser Pro Leu Trp Leu
 305                 310                 315                 320
 Gln Trp Leu Pro Gln Pro Gln Pro Arg Val Arg Pro Arg Lys Arg Arg
                 325                 330                 335    
 Arg Pro Arg Pro Arg Arg Ala Pro Val Leu Ser Thr His His Ala Ala
             340                 345                 350        
 Arg Val Ser Leu His Arg Trp Gly Gly Cys Gly Pro His Cys Arg Leu
         355                 360                 365            
 Arg Gly Glu Ala Leu Val Ala Leu Gly Gln Pro Pro His Ala Arg Trp
     370                 375                 380                
 Ala Pro Gln Gln Asp Trp His Trp Ala Arg Arg Tyr Gly Leu Pro Tyr
 385                 390                 395                 400
 Val Val Arg Val Asp Leu Arg Arg Leu Ala Pro Ala Pro Pro Ala Thr
                 405                 410                 415    
 Pro Ala Pro Ala Gly Thr Pro Gly Pro Ile Leu Ile Pro Lys Gln Ala
             420                 425                 430        
 Leu Ala Phe Ala Pro Phe Ser Pro Pro Lys Arg Leu Arg Leu Val Val
         435                 440                 445            
 Ser His Gly Ser Ile Asp Leu Asp Val Gly Gly Glu Glu Leu
     450                 455                 460        



      <210> 722
      <211> 422
      <212> PRT
      <213> Homo sapiens


      <400> 722
 Met Arg Lys Trp Arg His Arg Glu Val Asn Leu Pro Glu Val Thr Gln
   1               5                  10                  15    
 Gln Asp Ala Val Cys Pro Ala Pro Ile Pro Ser Pro Gly Leu Ser Ala
              20                  25                  30        
 Gln Thr Gly Leu Gln Lys Ile Trp Gly Thr Ile His Cys Gln Val Cys
          35                  40                  45            
 Pro Gly Ala Pro Ala Trp Pro Gly Ser Pro Trp His Glu Glu Met Gly
      50                  55                  60                
 Leu Leu Leu Leu Val Pro Leu Leu Leu Leu Pro Gly Ser Tyr Gly Leu
  65                  70                  75                  80
 Pro Phe Tyr Asn Gly Phe Tyr Tyr Ser Asn Ser Ala Asn Asp Gln Asn
                  85                  90                  95    
 Leu Gly Asn Gly His Gly Lys Asp Leu Leu Asn Gly Val Lys Leu Val
             100                 105                 110        
 Val Glu Thr Pro Glu Glu Thr Leu Phe Thr Tyr Gln Gly Ala Ser Val
         115                 120                 125            
 Ile Leu Pro Cys Arg Tyr Arg Tyr Glu Pro Ala Leu Val Ser Pro Arg
     130                 135                 140                
 Arg Val Arg Val Lys Trp Trp Lys Leu Ser Glu Asn Gly Ala Pro Glu
 145                 150                 155                 160
 Lys Asp Val Leu Val Ala Ile Gly Leu Arg His Arg Ser Phe Gly Asp
                 165                 170                 175    
 Tyr Gln Gly Arg Val His Leu Arg Gln Asp Lys Glu His Asp Val Ser
             180                 185                 190        
 Leu Glu Ile Gln Asp Leu Arg Leu Glu Asp Tyr Gly Arg Tyr Arg Cys
         195                 200                 205            
 Glu Val Ile Asp Gly Leu Glu Asp Glu Ser Gly Leu Val Glu Leu Glu
     210                 215                 220                
 Leu Arg Gly Val Val Phe Pro Tyr Gln Ser Pro Asn Gly Arg Tyr Gln
 225                 230                 235                 240
 Phe Asn Phe His Glu Gly Gln Gln Val Cys Ala Glu Gln Ala Ala Val
                 245                 250                 255    
 Val Ala Ser Phe Glu Gln Leu Phe Arg Ala Trp Glu Glu Gly Leu Asp
             260                 265                 270        
 Trp Cys Asn Ala Gly Trp Leu Gln Asp Ala Thr Val Gln Tyr Pro Ile
         275                 280                 285            
 Met Leu Pro Arg Gln Pro Cys Gly Gly Pro Gly Leu Ala Pro Gly Val
     290                 295                 300                
 Arg Ser Tyr Gly Pro Arg His Arg Arg Leu His Arg Tyr Asp Val Phe
 305                 310                 315                 320
 Cys Phe Ala Thr Ala Leu Lys Gly Arg Val Tyr Tyr Leu Glu His Pro
                 325                 330                 335    
 Glu Lys Leu Thr Leu Thr Glu Ala Arg Glu Ala Cys Gln Glu Asp Asp
             340                 345                 350        
 Ala Thr Ile Ala Lys Val Gly Gln Leu Phe Ala Ala Trp Lys Phe His
         355                 360                 365            
 Gly Leu Asp Arg Cys Asp Ala Gly Trp Leu Ala Asp Gly Ser Val Arg
     370                 375                 380                
 Tyr Pro Val Val His Pro His Pro Asn Cys Gly Pro Pro Glu Pro Gly
 385                 390                 395                 400
 Val Arg Ser Phe Gly Phe Pro Asp Pro Gln Ser Arg Leu Tyr Gly Val
                 405                 410                 415    
 Tyr Cys Tyr Arg Gln His
             420        



      <210> 723
      <211> 207
      <212> PRT
      <213> Homo sapiens


      <400> 723
 Met Asn Cys Glu Thr Ile Lys Ser Pro Thr Asp Thr Gln Lys Arg Val
   1               5                  10                  15    
 Ser Val Val Pro Arg Phe Ile Asn Ser Gln Lys Arg Arg Thr His Glu
              20                  25                  30        
 Ala Lys Gly Phe Ile Asn Lys Asp Val Ser Asp Pro Ile Phe Ser Leu
          35                  40                  45            
 Glu Gly Thr Gln Ser Pro Leu His Trp Asn Phe Lys Lys Asn Ile Trp
      50                  55                  60                
 Glu Gln Glu Asn His Pro Phe Asn Leu Gln Tyr Gly Ala Gln Gln Thr
  65                  70                  75                  80
 Ala Cys Asn Lys Leu Tyr Ser Gln Lys Gly Asn Leu Phe Thr Asp Gln
                  85                  90                  95    
 Gln Lys Cys Leu Ser Asp Glu Ser Glu Gly Leu Thr Cys Glu Ser Ser
             100                 105                 110        
 Lys Asp Glu Thr Phe Trp Arg Glu Leu Pro Ser Val Pro Ser Leu Asp
         115                 120                 125            
 Leu Phe Arg Ala Ser Asp Ser Asn Ala Asn Gln Lys Glu Phe Asn Ser
     130                 135                 140                
 Leu Tyr Phe Tyr Gln Arg Ala Gly Lys Ser Leu Gly Gln Lys Arg His
 145                 150                 155                 160
 His Glu Ser Ser Phe Asn Ser Gly Asp Lys Glu Ser Leu Thr Gly Phe
                 165                 170                 175    
 Met Cys Ser Gln Leu Pro Gln Phe Lys Lys Arg Arg Leu Ala Tyr Glu
             180                 185                 190        
 Lys Val Pro Gly Arg Val Asp Gly Gln Thr Arg Leu Arg Phe Phe
         195                 200                 205        



      <210> 724
      <211> 522
      <212> PRT
      <213> Homo sapiens


      <400> 724
 Met Ser Ala Ser Glu Gly Met Lys Phe Lys Phe His Ser Gly Glu Lys
   1               5                  10                  15    
 Val Leu Cys Phe Glu Pro Asp Pro Thr Lys Ala Arg Val Leu Tyr Asp
              20                  25                  30        
 Ala Lys Ile Val Asp Val Ile Val Gly Lys Asp Glu Lys Gly Arg Lys
          35                  40                  45            
 Ile Pro Glu Tyr Leu Ile His Phe Asn Gly Trp Asn Arg Ser Trp Asp
      50                  55                  60                
 Arg Trp Ala Ala Glu Asp His Val Leu Arg Asp Thr Asp Glu Asn Arg
  65                  70                  75                  80
 Arg Leu Gln Arg Lys Leu Ala Arg Lys Ala Val Ala Arg Leu Arg Ser
                  85                  90                  95    
 Thr Gly Arg Lys Lys Lys Arg Cys Arg Leu Pro Gly Val Asp Ser Val
             100                 105                 110        
 Leu Lys Gly Leu Pro Thr Glu Glu Lys Asp Glu Asn Asp Glu Asn Ser
         115                 120                 125            
 Leu Ser Ser Ser Ser Asp Cys Ser Glu Asn Lys Asp Glu Glu Ile Ser
     130                 135                 140                
 Glu Glu Ser Asp Ile Glu Glu Lys Thr Glu Val Lys Glu Glu Pro Glu
 145                 150                 155                 160
 Leu Gln Thr Arg Arg Glu Met Glu Glu Arg Thr Ile Thr Ile Glu Ile
                 165                 170                 175    
 Pro Glu Val Leu Lys Lys Gln Leu Glu Asp Asp Cys Tyr Tyr Ile Asn
             180                 185                 190        
 Arg Arg Lys Arg Leu Val Lys Leu Pro Cys Gln Thr Asn Ile Ile Thr
         195                 200                 205            
 Ile Leu Glu Ser Tyr Val Lys His Phe Ala Ile Asn Ala Ala Phe Ser
     210                 215                 220                
 Ala Asn Glu Arg Pro Arg His His His Val Met Pro His Ala Asn Met
 225                 230                 235                 240
 Asn Val His Tyr Ile Pro Ala Glu Lys Asn Val Asp Leu Cys Lys Glu
                 245                 250                 255    
 Met Val Asp Gly Leu Arg Ile Thr Phe Asp Tyr Thr Leu Pro Leu Val
             260                 265                 270        
 Leu Leu Tyr Pro Tyr Glu Gln Ala Gln Tyr Lys Lys Val Thr Ala Ser
         275                 280                 285            
 Lys Val Phe Leu Ala Ile Lys Glu Ser Ala Thr Asn Thr Asn Arg Ser
     290                 295                 300                
 Gln Glu Lys Leu Ser Pro Ser Leu Arg Leu Leu Asn Pro Ser Arg Pro
 305                 310                 315                 320
 Gln Ser Thr Glu Ser Gln Ser Thr Ser Gly Glu Pro Ala Thr Pro Lys
                 325                 330                 335    
 Arg Arg Lys Ala Glu Pro Gln Ala Val Gln Ser Leu Arg Arg Ser Ser
             340                 345                 350        
 Pro His Thr Ala Asn Cys Asp Arg Leu Ser Lys Ser Ser Thr Ser Pro
         355                 360                 365            
 Gln Pro Lys Arg Trp Gln Gln Asp Met Ser Thr Ser Val Pro Lys Leu
     370                 375                 380                
 Phe Leu His Leu Glu Lys Lys Thr Pro Val His Ser Arg Ser Ser Ser
 385                 390                 395                 400
 Pro Thr Leu Thr Pro Ser Gln Glu Gly Ser Pro Val Phe Ala Gly Phe
                 405                 410                 415    
 Glu Gly Arg Arg Thr Asn Glu Ile Asn Glu Val Leu Ser Trp Lys Leu
             420                 425                 430        
 Val Pro Asp Asn Tyr Pro Pro Gly Asp Gln Pro Pro Pro Pro Ser Tyr
         435                 440                 445            
 Ile Tyr Gly Ala Gln His Leu Leu Arg Leu Phe Val Lys Leu Pro Glu
     450                 455                 460                
 Ile Leu Gly Lys Met Ser Phe Thr Glu Lys Asn Leu Lys Ala Leu Leu
 465                 470                 475                 480
 Lys His Phe Asp Leu Phe Val Arg Phe Leu Ala Glu Tyr His Asp Asp
                 485                 490                 495    
 Phe Phe Pro Glu Ser Ala Tyr Val Ala Ala Ser Glu Val His Tyr Ser
             500                 505                 510        
 Thr Arg Asn Pro Gln Ala Val Asn Lys Cys
         515                 520        



      <210> 725
      <211> 266
      <212> PRT
      <213> Homo sapiens


      <400> 725
 Met Val Ser Pro Leu Pro Pro Pro Thr Pro Cys Arg Val Arg Gly Leu
   1               5                  10                  15    
 Gly Val Ser Gly Pro Ser Gly Lys Arg Arg Ala Ser Pro Leu Ser Cys
              20                  25                  30        
 Gly Ala Lys Met Ser Gly Glu Glu Asn Pro Ala Ser Lys Pro Thr Pro
          35                  40                  45            
 Val Gln Asp Val Gln Gly Asp Gly Arg Trp Met Ser Leu His His Arg
      50                  55                  60                
 Phe Val Ala Asp Ser Lys Asp Lys Glu Pro Glu Val Val Phe Ile Gly
  65                  70                  75                  80
 Asp Ser Leu Val Gln Leu Met His Gln Cys Glu Ile Trp Arg Glu Leu
                  85                  90                  95    
 Phe Ser Pro Leu His Ala Leu Asn Phe Gly Ile Gly Gly Asp Gly Thr
             100                 105                 110        
 Gln His Val Leu Trp Arg Leu Glu Asn Gly Glu Leu Glu His Ile Arg
         115                 120                 125            
 Pro Lys Ile Val Val Val Trp Val Gly Thr Asn Asn His Gly His Thr
     130                 135                 140                
 Ala Glu Gln Val Thr Gly Gly Ile Lys Ala Ile Val Gln Leu Val Asn
 145                 150                 155                 160
 Glu Arg Gln Pro Gln Ala Arg Val Val Val Leu Gly Leu Leu Pro Arg
                 165                 170                 175    
 Gly Gln His Pro Asn Pro Leu Arg Glu Lys Asn Arg Gln Val Asn Glu
             180                 185                 190        
 Leu Val Arg Ala Ala Leu Ala Gly His Pro Arg Ala His Phe Leu Asp
         195                 200                 205            
 Ala Asp Pro Gly Phe Val His Ser Asp Gly Thr Ile Ser His His Asp
     210                 215                 220                
 Met Tyr Asp Tyr Leu His Leu Ser Arg Leu Gly Tyr Thr Pro Val Cys
 225                 230                 235                 240
 Arg Ala Leu His Ser Leu Leu Leu Arg Leu Leu Ala Gln Asp Gln Gly
                 245                 250                 255    
 Gln Gly Ala Pro Leu Leu Glu Pro Ala Pro
             260                 265    



      <210> 726
      <211> 340
      <212> PRT
      <213> Homo sapiens


      <400> 726
 Met Gly Lys Ser Ile Pro Gln Tyr Leu Gly Gln Leu Asp Ile Arg Lys
   1               5                  10                  15    
 Ser Val Val Ser Leu Ala Thr Gly Ala Gly Ala Ile Tyr Leu Leu Tyr
              20                  25                  30        
 Lys Ala Ile Lys Ala Gly Ile Lys Cys Lys Pro Pro Leu Cys Ser Asn
          35                  40                  45            
 Ser Pro Ile Cys Ile Ala Arg Leu Ala Val Glu Arg Glu Arg His Gly
      50                  55                  60                
 Arg Asp Ser Gly Glu Leu Arg Arg Leu Leu Asn Ser Leu Glu Cys Lys
  65                  70                  75                  80
 Gln Asp Glu Tyr Ala Lys Ser Met Ile Leu His Ser Ile Thr Arg Cys
                  85                  90                  95    
 Val Tyr Leu Leu Glu Ala Glu Ala Ser Ala Cys Thr Thr Asp Asp Ile
             100                 105                 110        
 Val Leu Leu Gly Tyr Met Leu Asp Asp Lys Asp Asn Ser Val Lys Thr
         115                 120                 125            
 Gln Ala Leu Asn Thr Leu Lys Ala Phe Ser Gly Ile Arg Lys Phe Arg
     130                 135                 140                
 Leu Lys Ile Gln Glu His Ser Ile Lys Val Leu Glu Leu Ile Ser Thr
 145                 150                 155                 160
 Ile Trp Asp Thr Glu Leu His Ile Ala Gly Leu Arg Leu Leu Asn Asn
                 165                 170                 175    
 Leu Pro Leu Pro Asp Tyr Val His Pro Gln Leu Arg Arg Val Met Pro
             180                 185                 190        
 Ala Leu Met Glu Ile Leu Gln Ser Asp Tyr Ile Leu Ala Gln Val Gln
         195                 200                 205            
 Ala Val Arg Leu Leu Ser Tyr Leu Ala Gln Lys Asn Asp Leu Leu Tyr
     210                 215                 220                
 Asp Ile Leu Asn Cys Gln Val His Ser Asn Phe Leu Asn Leu Phe Gln
 225                 230                 235                 240
 Pro Thr Gln Ser Gly Ser Leu Leu Tyr Glu Val Leu Val Phe Ala Glu
                 245                 250                 255    
 Arg Leu Ser Glu Gly Arg Asn Ala Pro His Tyr His Val Val Lys Trp
             260                 265                 270        
 His Tyr Asn Glu Gln Ser Leu His Glu Ser Leu Phe Gly Glu Glu Ser
         275                 280                 285            
 Arg Leu Ala Asp Arg Leu Leu Ala Leu Val Ile His Pro Glu Glu Asp
     290                 295                 300                
 Val Gln Ile Gln Ala Cys Lys Val Ile Val Ser Leu Gln Tyr Pro Gln
 305                 310                 315                 320
 Asp Leu Arg Ala Arg Pro Ser Ser Cys Gln Pro Ser Arg Ser Tyr Phe
                 325                 330                 335    
 Lys Asn Thr Glu
             340



      <210> 727
      <211> 120
      <212> PRT
      <213> Homo sapiens


      <400> 727
 Met Thr Ile Thr Ser Leu Leu Asn Lys Ser Lys Ser Glu Met Thr Pro
   1               5                  10                  15    
 Glu Glu Leu Gln Lys Arg Glu Glu Glu Glu Phe Asn Thr Gly Pro Leu
              20                  25                  30        
 Ser Val Leu Thr Gln Ser Val Lys Asn Asn Thr Gln Val Leu Ile Asn
          35                  40                  45            
 Cys Arg His Asn Thr Lys Leu Leu Gly His Val Lys Ala Phe His Arg
      50                  55                  60                
 His Cys Asn Met Val Leu Glu Asn Val Lys Glu Thr Trp Thr Glu Val
  65                  70                  75                  80
 Pro Lys Ser Gly Lys Gly Lys Lys Ser Lys Pro Val Asn Lys Asp Cys
                  85                  90                  95    
 Tyr Ile Ser Arg Met Phe Leu His Gly Asp Leu Val Ile Val Val Leu
             100                 105                 110        
 Arg Asn Pro Leu Ile Ala Ser Lys
         115                 120



      <210> 728
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 728
 Met Gly Asp Leu Ser Arg Thr Ala Leu Trp Leu Gly Gly Arg Arg Asp
   1               5                  10                  15    
 Pro Ser Gly Ser Phe Arg Val Arg Asp Gly Ala Ala Ala Glu Val Gly
              20                  25                  30        
 Arg Ala Cys Leu Gly Leu Pro Ser Glu Cys Gly Ser Leu Val Arg Ala
          35                  40                  45            
 Arg Ala Ser Pro Arg Pro Leu Leu Gly Pro Ala Val Cys Pro Trp Arg
      50                  55                  60                
 Ala Arg Ser Pro Arg Pro Gly Leu Pro Arg Pro Ser Pro Thr Cys Pro
  65                  70                  75                  80
 Trp Lys Arg Gly Gly Asp Trp Cys Ala Leu Ser Leu Val Ala Pro Ala
                  85                  90                  95    
 Ala Ser Arg His Pro Pro Leu Ser Ala Ser Glu Gln Arg Ile Pro Pro
             100                 105                 110        
 Thr Ser Thr Cys Thr Cys Thr Arg Pro Leu Gly Asn Pro Leu Ala Phe
         115                 120                 125            
 Leu Thr Thr Val Gln Asn Gln Lys Gln Ile Glu His Trp Ala Glu Gln
     130                 135                 140                
 Gly Arg Arg Leu Leu Gly Lys Pro Glu Pro Leu Cys Lys Phe Ile Gln
 145                 150                 155                 160
 Ser Trp Gly
            



      <210> 729
      <211> 367
      <212> PRT
      <213> Homo sapiens


      <400> 729
 Met Gly Phe Trp Asn Leu Gln Asp Gln Tyr Gly Ile Pro Val Asp Pro
   1               5                  10                  15    
 Arg Val Arg Gln Gly Gly Gly Arg Arg Gly Cys Gly Ala Ser Phe Ser
              20                  25                  30        
 Lys Pro Ser Ser Ala Ile Leu Val Ala Ala Ala Thr His Ala Leu Ala
          35                  40                  45            
 Ala Ala Met Thr Glu Gln Met Thr Leu Arg Gly Thr Leu Lys Gly His
      50                  55                  60                
 Asn Gly Trp Val Thr Gln Ile Ala Thr Thr Pro Gln Phe Pro Asp Met
  65                  70                  75                  80
 Ile Leu Ser Ala Ser Arg Asp Lys Thr Ile Ile Met Trp Lys Leu Thr
                  85                  90                  95    
 Arg Asp Glu Thr Asn Tyr Gly Ile Pro Gln Arg Ala Leu Arg Gly His
             100                 105                 110        
 Ser His Phe Val Ser Asp Val Val Ile Ser Ser Asp Gly Gln Phe Ala
         115                 120                 125            
 Leu Ser Gly Ser Trp Asp Gly Thr Leu Arg Leu Trp Asp Leu Thr Thr
     130                 135                 140                
 Gly Thr Thr Thr Arg Arg Phe Val Gly His Thr Lys Asp Val Leu Ser
 145                 150                 155                 160
 Val Ala Phe Ser Ser Asp Asn Arg Gln Ile Val Ser Gly Ser Arg Asp
                 165                 170                 175    
 Lys Thr Ile Lys Leu Trp Asn Thr Leu Gly Val Cys Lys Tyr Thr Val
             180                 185                 190        
 Gln Asp Glu Ser His Ser Glu Trp Val Ser Cys Val Arg Phe Ser Pro
         195                 200                 205            
 Asn Ser Ser Asn Pro Ile Ile Val Ser Cys Gly Trp Asp Lys Leu Val
     210                 215                 220                
 Lys Val Trp Asn Leu Ala Asn Cys Lys Leu Lys Thr Asn His Ile Gly
 225                 230                 235                 240
 His Thr Gly Tyr Leu Asn Thr Val Thr Val Ser Pro Asp Gly Ser Leu
                 245                 250                 255    
 Cys Ala Ser Gly Gly Lys Asp Gly Gln Ala Met Leu Trp Asp Leu Asn
             260                 265                 270        
 Glu Gly Lys His Leu Tyr Thr Leu Asp Gly Gly Asp Ile Ile Asn Ala
         275                 280                 285            
 Leu Cys Phe Ser Pro Asn Arg Tyr Trp Leu Cys Ala Ala Thr Gly Pro
     290                 295                 300                
 Ser Ile Lys Ile Trp Asp Leu Glu Gly Lys Ile Ile Val Asp Glu Leu
 305                 310                 315                 320
 Lys Gln Glu Val Ile Ser Thr Ser Ser Lys Ala Glu Pro Pro Gln Cys
                 325                 330                 335    
 Thr Ser Leu Ala Trp Ser Ala Asp Gly Gln Thr Leu Phe Ala Gly Tyr
             340                 345                 350        
 Thr Asp Asn Leu Val Arg Val Trp Gln Val Thr Ile Gly Thr Arg
         355                 360                 365        



      <210> 730
      <211> 334
      <212> PRT
      <213> Homo sapiens


      <400> 730
 Met Thr Glu Gln Met Thr Leu Arg Gly Thr Leu Lys Gly His Asn Gly
   1               5                  10                  15    
 Trp Val Thr Gln Ile Ala Thr Thr Pro Gln Phe Pro Asp Met Ile Leu
              20                  25                  30        
 Ser Ala Ser Arg Asp Lys Thr Ile Ile Met Trp Lys Leu Thr Arg Asp
          35                  40                  45            
 Glu Thr Asn Tyr Gly Ile Pro Gln Arg Ala Leu Arg Gly His Ser His
      50                  55                  60                
 Phe Val Ser Asp Val Val Ile Ser Ser Asp Gly Gln Phe Ala Leu Ser
  65                  70                  75                  80
 Gly Ser Trp Asp Gly Thr Leu Arg Leu Trp Asp Leu Thr Thr Gln Val
                  85                  90                  95    
 Ala Ala His Leu Ala Leu Gly Pro Trp Glu Glu Ser Gly Gln Lys Gly
             100                 105                 110        
 Thr Thr Thr Arg Arg Phe Val Gly His Thr Lys Asp Val Leu Ser Val
         115                 120                 125            
 Ala Phe Ser Ser Asp Asn Arg Gln Ile Val Ser Gly Ser Arg Asp Lys
     130                 135                 140                
 Thr Ile Lys Leu Trp Asn Thr Leu Gly Val Cys Lys Tyr Thr Val Gln
 145                 150                 155                 160
 Asp Glu Ser His Ser Glu Trp Val Ser Cys Val Arg Phe Ser Pro Asn
                 165                 170                 175    
 Ser Ser Asn Pro Ile Ile Val Ser Cys Gly Trp Asp Lys Leu Val Lys
             180                 185                 190        
 Val Trp Asn Leu Ala Asn Cys Lys Leu Lys Thr Asn His Ile Gly His
         195                 200                 205            
 Thr Gly Tyr Leu Asn Thr Val Thr Val Ser Pro Asp Gly Ser Leu Cys
     210                 215                 220                
 Ala Ser Gly Gly Lys Asp Gly Gln Ala Met Leu Trp Asp Leu Asn Glu
 225                 230                 235                 240
 Gly Lys His Leu Tyr Thr Leu Asp Gly Gly Asp Ile Ile Asn Ala Leu
                 245                 250                 255    
 Cys Phe Ser Pro Asn Arg Tyr Trp Leu Cys Ala Ala Thr Gly Pro Ser
             260                 265                 270        
 Ile Lys Ile Trp Asp Leu Glu Gly Lys Ile Ile Val Asp Glu Leu Lys
         275                 280                 285            
 Gln Glu Val Ile Ser Thr Ser Ser Lys Ala Glu Pro Pro Gln Cys Thr
     290                 295                 300                
 Ser Leu Ala Trp Ser Ala Asp Gly Gln Thr Leu Phe Ala Gly Tyr Thr
 305                 310                 315                 320
 Asp Asn Leu Val Arg Val Trp Gln Val Thr Ile Gly Thr Arg
                 325                 330                



      <210> 731
      <211> 851
      <212> PRT
      <213> Homo sapiens


      <400> 731
 Met Pro Lys Ser Gly Phe Thr Lys Pro Ile Gln Ser Glu Asn Ser Asp
   1               5                  10                  15    
 Ser Asp Ser Asn Met Val Glu Lys Pro Tyr Gly Arg Lys Ser Lys Asp
              20                  25                  30        
 Lys Ile Ala Ser Tyr Ser Lys Thr Pro Lys Ile Glu Arg Ser Asp Val
          35                  40                  45            
 Ser Lys Glu Met Lys Glu Lys Ser Ser Met Lys Arg Lys Leu Pro Phe
      50                  55                  60                
 Thr Ile Ser Pro Ser Arg Asn Glu Glu Arg Asp Ser Asp Thr Glu Lys
  65                  70                  75                  80
 Glu Gly Pro Glu Lys Lys Lys Thr Lys Lys Glu Ala Gly Asn Lys Lys
                  85                  90                  95    
 Ser Thr Pro Val Ser Ile Leu Phe Gly Tyr Pro Leu Ser Glu Arg Lys
             100                 105                 110        
 Gln Met Ala Leu Leu Met Gln Met Thr Ala Arg Asp Asn Ser Pro Asp
         115                 120                 125            
 Ser Thr Pro Asn His Pro Ser Gln Thr Thr Pro Ala Gln Lys Lys Thr
     130                 135                 140                
 Pro Ser Ser Ser Ser Arg Gln Lys Asp Lys Val Asn Lys Arg Asn Glu
 145                 150                 155                 160
 Arg Gly Glu Thr Pro Leu His Met Ala Ala Ile Arg Gly Asp Val Lys
                 165                 170                 175    
 Gln Val Lys Glu Leu Ile Ser Leu Gly Ala Asn Val Asn Val Lys Asp
             180                 185                 190        
 Phe Ala Gly Trp Thr Pro Leu His Glu Ala Cys Asn Val Gly Tyr Tyr
         195                 200                 205            
 Asp Val Ala Lys Ile Leu Ile Ala Ala Gly Ala Asp Val Asn Thr Gln
     210                 215                 220                
 Gly Leu Asp Asp Asp Thr Pro Leu His Asp Ser Ala Ser Ser Gly His
 225                 230                 235                 240
 Arg Asp Ile Val Lys Leu Leu Leu Arg His Gly Gly Asn Pro Phe Gln
                 245                 250                 255    
 Ala Asn Lys His Gly Glu Arg Pro Val Asp Val Ala Glu Thr Glu Glu
             260                 265                 270        
 Leu Glu Leu Leu Leu Lys Arg Glu Val Pro Leu Ser Asp Asp Asp Glu
         275                 280                 285            
 Ser Tyr Thr Asp Ser Glu Glu Ala Gln Ser Val Asn Pro Ser Ser Val
     290                 295                 300                
 Asp Glu Asn Ile Asp Ser Glu Thr Glu Lys Asp Ser Leu Ile Cys Glu
 305                 310                 315                 320
 Ser Lys Gln Ile Leu Pro Ser Lys Thr Pro Leu Pro Ser Ala Leu Asp
                 325                 330                 335    
 Glu Tyr Glu Phe Lys Asp Asp Asp Asp Glu Glu Ile Asn Lys Met Ile
             340                 345                 350        
 Asp Asp Arg His Ile Leu Arg Lys Glu Gln Arg Lys Glu Asn Glu Pro
         355                 360                 365            
 Glu Ala Glu Lys Thr His Leu Phe Ala Lys Gln Glu Lys Ala Phe Tyr
     370                 375                 380                
 Pro Lys Ser Phe Lys Ser Lys Lys Gln Lys Pro Ser Arg Val Leu Tyr
 385                 390                 395                 400
 Ser Ser Thr Glu Ser Ser Asp Glu Glu Ala Leu Gln Asn Lys Lys Ile
                 405                 410                 415    
 Ser Thr Ser Cys Ser Val Ile Pro Glu Thr Ser Asn Ser Asp Met Gln
             420                 425                 430        
 Thr Lys Lys Glu Tyr Val Val Ser Gly Glu His Lys Gln Lys Gly Lys
         435                 440                 445            
 Val Lys Arg Lys Leu Lys Asn Gln Asn Lys Asn Lys Glu Asn Gln Glu
     450                 455                 460                
 Leu Lys Gln Glu Lys Glu Gly Lys Glu Asn Thr Arg Ile Thr Asn Leu
 465                 470                 475                 480
 Thr Val Asn Thr Gly Leu Asp Cys Ser Glu Lys Thr Arg Glu Glu Gly
                 485                 490                 495    
 Asn Phe Arg Lys Ser Phe Ser Pro Lys Asp Asp Thr Ser Leu His Leu
             500                 505                 510        
 Phe His Ile Ser Thr Gly Lys Ser Pro Lys His Ser Cys Gly Leu Ser
         515                 520                 525            
 Glu Lys Gln Ser Thr Pro Leu Lys Gln Glu His Thr Lys Thr Cys Leu
     530                 535                 540                
 Ser Pro Gly Ser Ser Glu Met Ser Leu Gln Pro Asp Leu Val Arg Tyr
 545                 550                 555                 560
 Asp Asn Thr Glu Ser Glu Phe Leu Pro Glu Ser Ser Ser Val Lys Ser
                 565                 570                 575    
 Cys Lys His Lys Glu Lys Ser Lys His Gln Lys Asp Phe His Leu Glu
             580                 585                 590        
 Phe Gly Glu Lys Ser Asn Ala Lys Ile Lys Asp Glu Asp His Ser Pro
         595                 600                 605            
 Thr Phe Glu Asn Ser Asp Cys Thr Leu Lys Lys Met Asp Lys Glu Gly
     610                 615                 620                
 Lys Thr Leu Lys Lys His Lys Leu Lys His Lys Glu Arg Glu Lys Glu
 625                 630                 635                 640
 Lys His Lys Lys Glu Ile Glu Gly Glu Lys Glu Lys Tyr Lys Thr Lys
                 645                 650                 655    
 Asp Ser Ala Lys Glu Leu Gln Arg Ser Val Glu Phe Asp Arg Glu Phe
             660                 665                 670        
 Trp Lys Glu Asn Phe Phe Lys Ser Asp Glu Thr Glu Asp Leu Phe Leu
         675                 680                 685            
 Asn Met Glu His Glu Ser Leu Thr Leu Glu Lys Lys Ser Lys Leu Glu
     690                 695                 700                
 Lys Asn Ile Lys Asp Asp Lys Ser Thr Lys Glu Lys His Val Ser Lys
 705                 710                 715                 720
 Glu Arg Asn Phe Lys Glu Glu Arg Asp Lys Ile Lys Lys Glu Ser Glu
                 725                 730                 735    
 Lys Ser Phe Arg Glu Glu Lys Ile Lys Asp Leu Lys Glu Glu Arg Glu
             740                 745                 750        
 Asn Ile Pro Thr Asp Lys Asp Ser Glu Phe Thr Ser Leu Gly Met Ser
         755                 760                 765            
 Ala Ile Glu Glu Ser Ile Gly Leu His Leu Val Glu Lys Glu Ile Asp
     770                 775                 780                
 Ile Glu Lys Gln Glu Lys His Ile Lys Glu Ser Lys Glu Lys Pro Glu
 785                 790                 795                 800
 Lys Arg Ser Gln Ile Lys Glu Lys Asp Ile Glu Lys Met Glu Arg Lys
                 805                 810                 815    
 Thr Phe Glu Lys Lys Lys Lys Ile Lys His Glu His Lys Ser Glu Lys
             820                 825                 830        
 Asp Lys Leu Asp Leu Ser Glu Cys Val Asp Lys Lys Lys Lys Lys Gly
         835                 840                 845            
 Arg Pro Leu
     850    



      <210> 732
      <211> 454
      <212> PRT
      <213> Homo sapiens


      <400> 732
 Met Phe Gln Ala Gly Asn Arg Arg Lys Lys Glu Arg His Lys Ser Thr
   1               5                  10                  15    
 Ser Lys Gln Arg Arg Lys Lys Arg Lys Asn Pro Ser Leu Thr Asn Ala
              20                  25                  30        
 Glu Phe Glu Glu Met Val Gln Ile Val Leu Gln Lys Ser Leu Gln Glu
          35                  40                  45            
 Cys Leu Gly Met Gly Ser Gly Leu Asp Phe Ala Glu Thr Ser Cys Ala
      50                  55                  60                
 Gln Pro Val Val Ser Thr Gln Ser Asp Lys Glu Pro Gly Ile Thr Ala
  65                  70                  75                  80
 Ser Ala Thr Asp Thr Asp Asn Ala Asn Gly Glu Glu Val Pro His Thr
                  85                  90                  95    
 Gln Glu Ile Ser Val Ser Trp Glu Gly Glu Ala Ala Pro Glu Ile Arg
             100                 105                 110        
 Thr Ser Lys Leu Gly Gln Pro Asp Pro Ala Pro Ser Lys Lys Lys Ser
         115                 120                 125            
 Asn Arg Leu Thr Leu Ser Lys Arg Lys Lys Glu Ala Gln Asp Glu Lys
     130                 135                 140                
 Val Glu Lys Thr Gln Gly Gly His Glu His Arg Gln Glu Asp Arg Leu
 145                 150                 155                 160
 Lys Lys Thr Val Gln Asp His Ser Gln Ile Arg Asp Gln Gln Lys Gly
                 165                 170                 175    
 Glu Ile Ser Gly Phe Gly Gln Cys Leu Val Trp Val Gln Cys Ser Phe
             180                 185                 190        
 Pro Asn Cys Gly Lys Trp Arg Arg Leu Cys Gly Asn Ile Asp Pro Ser
         195                 200                 205            
 Val Leu Pro Asp Asn Trp Ser Cys Asp Gln Asn Thr Asp Val Gln Tyr
     210                 215                 220                
 Asn Arg Cys Asp Ile Pro Glu Glu Thr Trp Thr Gly Leu Glu Ser Asp
 225                 230                 235                 240
 Val Ala Tyr Ala Ser Tyr Ile Pro Gly Ser Ile Ile Trp Ala Lys Gln
                 245                 250                 255    
 Tyr Gly Tyr Pro Trp Trp Pro Gly Met Ile Glu Ser Asp Pro Asp Leu
             260                 265                 270        
 Gly Glu Tyr Phe Leu Phe Thr Ser His Leu Asp Ser Leu Pro Ser Lys
         275                 280                 285            
 Tyr His Val Thr Phe Phe Gly Glu Thr Val Ser Arg Ala Trp Ile Pro
     290                 295                 300                
 Val Asn Met Leu Lys Asn Phe Gln Glu Leu Ser Leu Glu Leu Ser Val
 305                 310                 315                 320
 Met Lys Lys Arg Arg Asn Asp Cys Ser Gln Lys Leu Gly Val Ala Leu
                 325                 330                 335    
 Met Met Ala Gln Glu Ala Glu Gln Ile Ser Ile Gln Glu Arg Val Asn
             340                 345                 350        
 Leu Phe Gly Phe Trp Ser Arg Phe Asn Gly Ser Asn Ser Asn Gly Glu
         355                 360                 365            
 Arg Lys Asp Leu Gln Leu Ser Gly Leu Asn Ser Pro Gly Ser Cys Leu
     370                 375                 380                
 Glu Lys Lys Glu Lys Glu Glu Glu Leu Glu Lys Glu Glu Gly Glu Lys
 385                 390                 395                 400
 Thr Ala Leu Arg Lys Asn Leu Lys Leu Pro Arg Ala Arg Pro Trp Gln
                 405                 410                 415    
 Pro Ala Phe Gln Arg Glu Lys Lys Leu Glu Gln Cys Gln Arg Thr Trp
             420                 425                 430        
 Ala Tyr Gln Arg Val Arg Gly Pro Ala Pro His Leu Arg Lys Lys Ser
         435                 440                 445            
 Pro Asp Thr Gly Asn Pro
     450                



      <210> 733
      <211> 139
      <212> PRT
      <213> Homo sapiens


      <400> 733
 Met Ser Pro Leu Leu Ala Val Leu Gln Ala Thr Arg Arg Arg Glu Glu
   1               5                  10                  15    
 Arg Arg Pro Phe Gln Glu Pro Arg Leu Arg Gly Phe Leu Ser Gln Cys
              20                  25                  30        
 Cys Asp Thr Pro Phe Arg Ala Leu Arg Phe Leu Ala Ser Pro Ser Phe
          35                  40                  45            
 Gln Val Pro Leu His Ser Pro Arg Pro Asp Ala Gly Ala His Ser Arg
      50                  55                  60                
 Ser Arg Leu Gln Cys Ile Ser Ser Ser Cys Arg Leu Ala Trp Ser Gln
  65                  70                  75                  80
 Gln Leu Cys Trp His Leu Glu Leu Pro Ala Leu Pro Gly Cys Val Gln
                  85                  90                  95    
 Trp Pro Pro Val Cys Leu Ala Val Cys Ser Gly Trp Thr Pro His Ser
             100                 105                 110        
 Leu Thr His Ala Leu Pro Leu Cys Ala Phe Leu Ala Leu Gly Arg Leu
         115                 120                 125            
 Gly Ile Arg Ala Gly Ser Thr Ser Leu Pro Gly
     130                 135                



      <210> 734
      <211> 171
      <212> PRT
      <213> Homo sapiens


      <400> 734
 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala
   1               5                  10                  15    
 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ser
              20                  25                  30        
 Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala
          35                  40                  45            
 Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg
      50                  55                  60                
 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys
  65                  70                  75                  80
 Thr Asp Leu Arg Phe Gln Ser Ala Ala Ile Gly Ala Leu Gln Glu Ala
                  85                  90                  95    
 Ser Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala
             100                 105                 110        
 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala
         115                 120                 125            
 Arg Arg Ile Pro Gly Thr Arg Asp Ala Phe Arg Asp Gly Ser Ser Leu
     130                 135                 140                
 Trp Arg Leu Val Arg Tyr Leu Leu Tyr His Tyr Phe Gly Leu Leu Cys
 145                 150                 155                 160
 Asp Phe Ser Cys Lys Asn Ile Val Tyr Asn Met
                 165                 170    



      <210> 735
      <211> 391
      <212> PRT
      <213> Homo sapiens


      <400> 735
 Met Asp Met Leu Asp Pro Gly Leu Asp Pro Ala Ala Ser Ala Thr Ala
   1               5                  10                  15    
 Ala Ala Ala Ala Ser His Asp Lys Gly Pro Glu Ala Glu Glu Gly Val
              20                  25                  30        
 Glu Leu Gln Glu Gly Gly Asp Gly Pro Gly Ala Glu Glu Gln Thr Ala
          35                  40                  45            
 Val Ala Ile Thr Ser Val Gln Gln Ala Ala Phe Gly Asp His Asn Ile
      50                  55                  60                
 Gln Tyr Gln Phe Arg Thr Glu Thr Asn Gly Gly Gln Val Thr Tyr Arg
  65                  70                  75                  80
 Val Val Gln Val Thr Asp Gly Gln Leu Asp Gly Gln Gly Asp Thr Ala
                  85                  90                  95    
 Gly Ala Val Ser Val Val Ser Thr Ala Ala Phe Ala Gly Gly Gln Gln
             100                 105                 110        
 Ala Val Thr Gln Ala Val Ile Gln Asn Pro Phe Ser Asn Gly Gly Ser
         115                 120                 125            
 Pro Ala Ala Glu Ala Val Ser Gly Glu Ala Arg Phe Ala Tyr Phe Pro
     130                 135                 140                
 Ala Ser Ser Val Gly Asp Thr Thr Ala Val Ser Val Gln Thr Thr Asp
 145                 150                 155                 160
 Gln Ser Leu Gln Ala Gly Gly Gln Phe Tyr Val Met Met Thr Pro Gln
                 165                 170                 175    
 Asp Val Leu Gln Thr Gly Thr Gln Arg Thr Ile Ala Pro Arg Thr His
             180                 185                 190        
 Pro Tyr Ser Pro Lys Ile Asp Gly Thr Arg Thr Pro Arg Asp Glu Arg
         195                 200                 205            
 Arg Arg Ala Gln His Asn Glu Asp Met Ala Met Gln Gln Met Ile Gly
     210                 215                 220                
 Gln Thr Arg Ser Gln Leu Ser Val Arg Val Leu Val Gly Glu Met Gly
 225                 230                 235                 240
 Val Thr Gln Pro His Gln Ala Val Gln Ala Val Thr Gly Arg Arg Gly
                 245                 250                 255    
 Lys Leu Gly Lys Lys Val Ala Gly Asp Gly Gly Met Val Val Cys Ser
             260                 265                 270        
 Glu Gly Leu Phe Glu Ser Glu Ile Ser Arg Ala Val Pro Val Pro Met
         275                 280                 285            
 Glu Arg Arg Arg Arg Asp Lys Ile Asn Asn Trp Ile Val Gln Leu Ser
     290                 295                 300                
 Lys Ile Ile Pro Asp Cys Asn Ala Asp Asn Ser Lys Thr Gly Ala Ser
 305                 310                 315                 320
 Lys Gly Gly Ile Leu Ser Lys Ala Cys Asp Tyr Ile Arg Glu Leu Arg
                 325                 330                 335    
 Gln Thr Asn Gln Arg Met Gln Glu Thr Phe Lys Glu Ala Glu Arg Leu
             340                 345                 350        
 Gln Met Asp Asn Glu Leu Leu Arg Gln Gln Ile Glu Glu Leu Lys Asn
         355                 360                 365            
 Glu Asn Ala Leu Leu Arg Ala Gln Leu Gln Gln His Asn Leu Glu Met
     370                 375                 380                
 Val Gly Glu Gly Thr Arg Gln
 385                 390    



      <210> 736
      <211> 859
      <212> PRT
      <213> Homo sapiens


      <400> 736
 Met Ala Ala Ala Thr Gly Ala Val Ala Ala Ser Ala Ala Ser Gly Gln
   1               5                  10                  15    
 Ala Glu Gly Lys Lys Ile Thr Asp Leu Arg Val Ile Asp Leu Lys Ser
              20                  25                  30        
 Glu Leu Lys Arg Arg Asn Leu Asp Ile Thr Gly Val Lys Thr Val Leu
          35                  40                  45            
 Ile Ser Arg Leu Lys Gln Ala Ile Glu Glu Glu Gly Gly Asp Pro Asp
      50                  55                  60                
 Asn Ile Glu Leu Thr Val Ser Thr Asp Thr Pro Asn Lys Lys Pro Thr
  65                  70                  75                  80
 Lys Gly Lys Gly Lys Lys His Glu Ala Asp Glu Leu Ser Gly Asp Ala
                  85                  90                  95    
 Ser Val Glu Asp Asp Ala Phe Ile Lys Asp Cys Glu Leu Glu Asn Gln
             100                 105                 110        
 Glu Ala His Glu Gln Asp Gly Asn Asp Glu Leu Lys Asp Ser Glu Glu
         115                 120                 125            
 Phe Gly Glu Asn Glu Glu Glu Asn Val His Ser Lys Glu Leu Leu Ser
     130                 135                 140                
 Ala Glu Glu Asn Lys Arg Ala His Glu Leu Ile Glu Ala Glu Gly Ile
 145                 150                 155                 160
 Glu Asp Ile Glu Lys Glu Asp Ile Glu Ser Gln Glu Ile Glu Ala Gln
                 165                 170                 175    
 Glu Gly Glu Asp Asp Thr Phe Leu Thr Ala Gln Asp Gly Glu Glu Glu
             180                 185                 190        
 Glu Asn Glu Lys Asp Ile Ala Gly Ser Gly Asp Gly Thr Gln Glu Val
         195                 200                 205            
 Ser Lys Pro Leu Pro Ser Glu Gly Ser Leu Ala Glu Ala Asp His Thr
     210                 215                 220                
 Ala His Glu Glu Met Glu Ala His Thr Thr Val Lys Glu Ala Glu Asp
 225                 230                 235                 240
 Asp Asn Ile Ser Val Thr Ile Gln Ala Glu Asp Ala Ile Thr Leu Asp
                 245                 250                 255    
 Phe Asp Gly Asp Asp Leu Leu Glu Thr Gly Lys Asn Val Lys Ile Thr
             260                 265                 270        
 Asp Ser Glu Ala Ser Lys Pro Lys Asp Gly Gln Asp Ala Ile Ala Gln
         275                 280                 285            
 Ser Pro Glu Lys Glu Ser Lys Asp Tyr Glu Met Asn Ala Asn His Lys
     290                 295                 300                
 Asp Gly Lys Lys Glu Asp Cys Val Lys Gly Asp Pro Val Glu Lys Glu
 305                 310                 315                 320
 Ala Arg Glu Ser Ser Lys Lys Ala Glu Ser Gly Asp Lys Glu Lys Asp
                 325                 330                 335    
 Thr Leu Lys Lys Gly Pro Ser Ser Thr Gly Ala Ser Gly Gln Ala Lys
             340                 345                 350        
 Ser Ser Ser Lys Glu Ser Lys Asp Ser Lys Thr Ser Ser Lys Asp Asp
         355                 360                 365            
 Lys Gly Ser Thr Ser Ser Thr Ser Gly Ser Ser Gly Ser Ser Thr Lys
     370                 375                 380                
 Asn Ile Trp Val Ser Gly Leu Ser Ser Asn Thr Lys Ala Ala Asp Leu
 385                 390                 395                 400
 Lys Asn Leu Phe Gly Lys Tyr Gly Lys Val Leu Ser Ala Lys Val Val
                 405                 410                 415    
 Thr Asn Ala Arg Ser Pro Gly Ala Lys Cys Tyr Gly Ile Val Thr Met
             420                 425                 430        
 Ser Ser Ser Thr Glu Val Ser Arg Cys Ile Ala His Leu His Arg Thr
         435                 440                 445            
 Glu Leu His Gly Gln Leu Ile Ser Val Glu Lys Val Lys Gly Asp Pro
     450                 455                 460                
 Ser Lys Lys Glu Met Lys Lys Glu Asn Asp Glu Lys Ser Ser Ser Arg
 465                 470                 475                 480
 Ser Ser Gly Asp Lys Lys Asn Thr Ser Asp Arg Ser Ser Lys Thr Gln
                 485                 490                 495    
 Ala Ser Val Lys Lys Glu Glu Lys Arg Ser Ser Glu Lys Ser Glu Lys
             500                 505                 510        
 Lys Glu Ser Lys Asp Thr Lys Lys Ile Glu Gly Lys Asp Glu Lys Asn
         515                 520                 525            
 Asp Asn Gly Ala Ser Gly Gln Thr Ser Glu Ser Ile Lys Lys Ser Glu
     530                 535                 540                
 Glu Lys Lys Arg Ile Ser Ser Lys Ser Pro Gly His Met Val Ile Leu
 545                 550                 555                 560
 Asp Gln Thr Lys Gly Asp His Cys Arg Pro Ser Arg Arg Gly Arg Tyr
                 565                 570                 575    
 Glu Lys Ile His Gly Arg Ser Lys Glu Lys Glu Arg Ala Ser Leu Asp
             580                 585                 590        
 Lys Lys Arg Asp Lys Asp Tyr Arg Arg Lys Glu Ile Leu Pro Phe Glu
         595                 600                 605            
 Lys Met Lys Glu Gln Arg Leu Arg Glu His Leu Val Arg Phe Glu Arg
     610                 615                 620                
 Leu Arg Arg Ala Met Glu Leu Arg Arg Arg Arg Glu Ile Ala Glu Arg
 625                 630                 635                 640
 Glu Arg Arg Glu Arg Glu Arg Ile Arg Ile Ile Arg Glu Arg Glu Glu
                 645                 650                 655    
 Arg Glu Arg Leu Gln Arg Glu Arg Glu Arg Leu Glu Ile Glu Arg Gln
             660                 665                 670        
 Lys Leu Glu Arg Glu Arg Met Glu Arg Glu Arg Leu Glu Arg Glu Arg
         675                 680                 685            
 Ile Arg Ile Glu Gln Glu Arg Arg Lys Glu Ala Glu Arg Ile Ala Arg
     690                 695                 700                
 Glu Arg Glu Glu Leu Arg Arg Gln Gln Gln Gln Leu Arg Tyr Glu Gln
 705                 710                 715                 720
 Glu Lys Arg Asn Ser Leu Lys Arg Pro Arg Asp Val Asp His Arg Arg
                 725                 730                 735    
 Asp Asp Pro Tyr Trp Ser Glu Asn Lys Lys Leu Ser Leu Asp Thr Asp
             740                 745                 750        
 Ala Arg Phe Gly His Gly Ser Asp Tyr Ser Arg Gln Gln Asn Arg Phe
         755                 760                 765            
 Asn Asp Phe Asp His Arg Glu Arg Gly Arg Phe Pro Glu Ser Ser Ala
     770                 775                 780                
 Val Gln Ser Ser Ser Phe Glu Arg Arg Asp Arg Phe Val Gly Gln Ser
 785                 790                 795                 800
 Glu Gly Lys Lys Ala Arg Pro Thr Ala Arg Arg Glu Asp Pro Ser Phe
                 805                 810                 815    
 Glu Arg Tyr Pro Lys Asn Phe Ser Asp Ser Arg Arg Asn Glu Pro Pro
             820                 825                 830        
 Pro Pro Arg Asn Glu Leu Arg Glu Ser Asp Arg Arg Glu Val Arg Gly
         835                 840                 845            
 Glu Arg Asp Glu Arg Arg Thr Val Ile Ile Ser
     850                 855                



      <210> 737
      <211> 352
      <212> PRT
      <213> Homo sapiens


      <400> 737
 Met Pro Asn Thr Leu Arg Leu Ser Ala Leu Thr Gln Glu Ala Leu Pro
   1               5                  10                  15    
 Gly His Ser Val Leu Arg Val Ala Phe Val Met Phe Pro Glu Leu Val
              20                  25                  30        
 Ser Ser Val Pro Phe Leu Gly Ala Ala Gly His Gln Gln Ser Leu Pro
          35                  40                  45            
 Ser Ser Trp Lys Ala Ser Cys Ser Gly Pro Leu Val Met Ala Ser Asp
      50                  55                  60                
 Ser Asp Val Lys Met Leu Leu Asn Phe Val Asn Leu Ala Ser Ser Asp
  65                  70                  75                  80
 Ile Lys Ala Ala Leu Asp Lys Ser Ala Pro Cys Arg Arg Ser Val Asp
                  85                  90                  95    
 His Arg Lys Tyr Leu Gln Lys Gln Leu Lys Arg Phe Ser Gln Lys Tyr
             100                 105                 110        
 Ser Arg Leu Pro Arg Gly Leu Pro Gly Arg Ala Ala Glu Pro Tyr Leu
         115                 120                 125            
 Lys Arg Gly Ser Glu Asp Arg Pro Arg Arg Leu Leu Leu Asp Leu Gly
     130                 135                 140                
 Pro Asp Ser Ser Pro Gly Gly Gly Gly Gly Cys Lys Glu Lys Val Leu
 145                 150                 155                 160
 Arg Asn Pro Tyr Arg Glu Glu Cys Leu Ala Lys Glu Gln Leu Pro Gln
                 165                 170                 175    
 Arg Gln His Pro Glu Ala Ala Gln Pro Gly Gln Val Pro Met Arg Lys
             180                 185                 190        
 Arg Gln Leu Pro Ala Ser Phe Trp Glu Glu Pro Arg Pro Thr His Ser
         195                 200                 205            
 Tyr His Val Gly Leu Glu Gly Gly Leu Gly Pro Arg Glu Gly Pro Pro
     210                 215                 220                
 Tyr Glu Gly Lys Lys Asn Cys Lys Gly Leu Glu Pro Leu Gly Pro Glu
 225                 230                 235                 240
 Thr Thr Leu Val Ser Met Ser Pro Arg Ala Leu Ala Glu Lys Glu Pro
                 245                 250                 255    
 Leu Lys Met Pro Gly Val Ser Leu Val Gly Arg Val Asn Ala Trp Ser
             260                 265                 270        
 Cys Cys Pro Phe Gln Tyr His Gly Gln Pro Ile Tyr Pro Gly Pro Leu
         275                 280                 285            
 Gly Ala Leu Pro Gln Ser Pro Val Pro Ser Leu Gly Leu Trp Arg Lys
     290                 295                 300                
 Ser Pro Ala Phe Pro Gly Glu Leu Ala His Leu Cys Lys Asp Val Asp
 305                 310                 315                 320
 Gly Leu Gly Gln Lys Val Cys Arg Pro Val Val Leu Lys Pro Ile Pro
                 325                 330                 335    
 Thr Lys Pro Ala Val Pro Pro Pro Ile Phe Asn Val Phe Gly Tyr Leu
             340                 345                 350        





      <210> 738
      <211> 426
      <212> PRT
      <213> Homo sapiens


      <400> 738
 Met Asn Gly Gln Leu Asp Leu Ser Gly Lys Leu Ile Ile Lys Ala Gln
   1               5                  10                  15    
 Leu Gly Glu Asp Ile Arg Arg Ile Pro Ile His Asn Glu Asp Ile Thr
              20                  25                  30        
 Tyr Asp Glu Leu Val Leu Met Met Gln Arg Val Phe Arg Gly Lys Leu
          35                  40                  45            
 Leu Ser Asn Asp Glu Val Thr Ile Lys Tyr Lys Asp Glu Asp Gly Asp
      50                  55                  60                
 Leu Ile Thr Ile Phe Asp Ser Ser Asp Leu Ser Phe Ala Ile Gln Cys
  65                  70                  75                  80
 Ser Arg Ile Leu Lys Leu Thr Leu Phe Val Asn Gly Gln Pro Arg Pro
                  85                  90                  95    
 Leu Glu Ser Ser Gln Val Lys Tyr Leu Arg Arg Glu Leu Ile Glu Leu
             100                 105                 110        
 Arg Asn Lys Val Asn Arg Leu Leu Asp Ser Leu Glu Pro Pro Gly Glu
         115                 120                 125            
 Pro Gly Pro Ser Thr Asn Ile Pro Glu Asn Asp Thr Val Asp Gly Arg
     130                 135                 140                
 Glu Glu Lys Ser Ala Ser Asp Ser Ser Gly Lys Gln Ser Thr Gln Val
 145                 150                 155                 160
 Met Ala Ala Ser Met Ser Ala Phe Asp Pro Leu Lys Asn Gln Asp Glu
                 165                 170                 175    
 Ser Ile Asn Asn Val Met Ser Ala Phe Gly Leu Thr Asp Asp Gln Val
             180                 185                 190        
 Ser Gly Pro Pro Ser Ala Pro Ala Glu Asp Arg Ser Gly Thr Pro Asp
         195                 200                 205            
 Ser Ile Ala Ser Ser Ser Ser Ala Ala His Pro Pro Gly Val Gln Pro
     210                 215                 220                
 Gln Gln Pro Pro Tyr Thr Gly Ala Gln Thr Gln Ala Gly Gln Ile Glu
 225                 230                 235                 240
 Gly Gln Met Tyr Gln Gln Tyr Gln Gln Gln Ala Gly Tyr Gly Ala Gln
                 245                 250                 255    
 Gln Pro Gln Ala Pro Pro Gln Gln Pro Gln Gln Tyr Gly Ile Gln Tyr
             260                 265                 270        
 Ser Ala Ser Tyr Ser Gln Gln Thr Gly Pro Gln Gln Pro Gln Gln Phe
         275                 280                 285            
 Gln Gly Tyr Gly Gln Gln Pro Thr Ser Gln Ala Pro Ala Pro Ala Phe
     290                 295                 300                
 Ser Gly Gln Pro Gln Gln Leu Pro Ala Gln Pro Pro Gln Gln Tyr Gln
 305                 310                 315                 320
 Ala Ser Asn Tyr Pro Ala Gln Thr Tyr Thr Ala Gln Thr Ser Gln Pro
                 325                 330                 335    
 Thr Asn Tyr Thr Val Ala Pro Ala Ser Gln Pro Gly Met Ala Pro Ser
             340                 345                 350        
 Gln Pro Gly Ala Tyr Gln Pro Arg Pro Gly Phe Thr Ser Leu Pro Gly
         355                 360                 365            
 Ser Thr Met Thr Pro Pro Gln Val Gly Leu Ile Leu Met Arg Val Thr
     370                 375                 380                
 Val Leu Pro Leu Val Arg Val Tyr Gln Leu Asp Leu Val Ile Asp Lys
 385                 390                 395                 400
 Glu Ala Pro Leu His Gln Leu Met Leu Ala Ala Ser Tyr Trp Pro Pro
                 405                 410                 415    
 Lys Arg Leu Gln Tyr Tyr Phe Asn Leu Tyr
             420                 425    



      <210> 739
      <211> 377
      <212> PRT
      <213> Homo sapiens


      <400> 739
 Met Ser Asp Lys Leu Pro Tyr Lys Val Ala Asp Ile Gly Leu Ala Thr
   1               5                  10                  15    
 Trp Gly His Lys Ala Leu Asp Ile Val Glu Asn Gly Cys Arg Glu His
              20                  25                  30        
 Ala Val Ala Val Phe Ala Glu Ala Gly Met Pro Val Phe Thr Trp Lys
          35                  40                  45            
 Gly Lys Met Lys Glu Gly Tyr Pro Trp Cys Ile Glu Gln Thr Leu Tyr
      50                  55                  60                
 Phe Lys Asp Gly Pro Leu Asn Met Ile Leu Asp Asp Gly Gly Asp Leu
  65                  70                  75                  80
 Thr Asn Leu Ile His Thr Lys Tyr Pro Gln Leu Leu Pro Gly Ile Arg
                  85                  90                  95    
 Gly Ile Ser Glu Glu Thr Thr Thr Gly Val His Asn Leu Tyr Lys Met
             100                 105                 110        
 Met Ala Asn Gly Ile Leu Lys Val Pro Ala Ile Asn Val Asn Asp Ser
         115                 120                 125            
 Val Thr Lys Ser Lys Phe Asp Asn Leu Tyr Gly Cys Arg Glu Ser Leu
     130                 135                 140                
 Ile Asp Gly Ile Lys Arg Ala Thr Asp Val Met Ile Ala Gly Lys Val
 145                 150                 155                 160
 Ala Val Val Ala Gly Tyr Gly Asp Val Gly Lys Gly Cys Ala Gln Ala
                 165                 170                 175    
 Leu Arg Gly Phe Gly Ala Arg Val Ile Ile Thr Glu Ile Asp Pro Ile
             180                 185                 190        
 Asn Ala Leu Gln Ala Ala Met Glu Gly Tyr Glu Val Thr Thr Met Asp
         195                 200                 205            
 Glu Ala Cys Gln Glu Gly Asn Ile Phe Val Thr Thr Thr Gly Cys Ile
     210                 215                 220                
 Asp Ile Ile Leu Gly Arg His Phe Glu Gln Met Lys Asp Asp Ala Ile
 225                 230                 235                 240
 Val Cys Asn Ile Gly His Phe Asp Val Glu Ile Asp Val Lys Trp Leu
                 245                 250                 255    
 Asn Glu Asn Ala Val Glu Lys Val Asn Ile Lys Pro Gln Val Asp Arg
             260                 265                 270        
 Tyr Arg Leu Lys Asn Gly Arg Arg Ile Ile Leu Leu Ala Glu Gly Arg
         275                 280                 285            
 Leu Val Asn Leu Gly Cys Ala Met Gly His Pro Ser Phe Val Met Ser
     290                 295                 300                
 Asn Ser Phe Thr Asn Gln Val Met Ala Gln Ile Glu Leu Trp Thr His
 305                 310                 315                 320
 Pro Asp Lys Tyr Pro Val Gly Val His Phe Leu Pro Lys Lys Leu Asp
                 325                 330                 335    
 Glu Ala Val Ala Glu Ala His Leu Gly Lys Leu Asn Val Lys Leu Thr
             340                 345                 350        
 Lys Leu Thr Glu Lys Gln Ala Gln Tyr Leu Gly Met Ser Cys Asp Gly
         355                 360                 365            
 Pro Phe Lys Pro Asp His Tyr Arg Tyr
     370                 375        



      <210> 740
      <211> 142
      <212> PRT
      <213> Homo sapiens


      <400> 740
 Met Leu His Thr Leu Tyr Arg Gln Pro His Lys Leu Gln Gly Leu Thr
   1               5                  10                  15    
 Ile Tyr Leu Gly Lys Tyr Leu Phe Ser Tyr Pro Pro Pro Arg Gln Lys
              20                  25                  30        
 Asp Pro Gln Lys Phe Pro Met Phe Thr Ala Pro Ala Leu Ile Leu Glu
          35                  40                  45            
 Pro Leu Pro Phe Thr Pro Asp Val Gln Arg Cys Met His Asn Val Gln
      50                  55                  60                
 Phe Leu Pro Ala Thr Gln Lys His Ala Gln Thr Asp Val Thr Val Gln
  65                  70                  75                  80
 Ser Pro Pro Ile Gly His Gly Thr Gln Gln Val Tyr Gly Met Phe Pro
                  85                  90                  95    
 Asn Ser Gly Tyr Tyr Thr Val Ser Thr Thr Val Asn Phe Val Asn Leu
             100                 105                 110        
 Lys Lys Lys Ser Val Ile Tyr Gly Phe Arg Ile Gln Lys Glu Ser Phe
         115                 120                 125            
 Cys Ile Glu Phe Thr Pro Asp Lys Gly Lys Thr Gly Cys Asp
     130                 135                 140        



      <210> 741
      <211> 141
      <212> PRT
      <213> Homo sapiens


      <400> 741
 Met Tyr Pro Ser Tyr Leu Leu Ile Phe Pro Pro Ile Pro Ser Gln Phe
   1               5                  10                  15    
 Leu Lys Gln Cys Pro Pro Pro Thr Leu Ser Asp Pro Phe Leu Pro Leu
              20                  25                  30        
 Ala Leu Arg Ser Leu Asp Val Leu Leu Leu Ser Ser Ala Pro Leu Val
          35                  40                  45            
 Ser His Ser Ser Pro Leu Glu Phe Ile Arg Val Ile Pro Val Glu Pro
      50                  55                  60                
 Pro Ser Cys Leu Ser Ile Pro Pro Ala Ser Leu Pro Arg Leu Leu Leu
  65                  70                  75                  80
 Leu Gln Asp Ser Asp Val Ser Leu Arg Ser Ala Val Arg Ser Ala Gly
                  85                  90                  95    
 Glu Leu Pro Thr Val Pro Gln Gly Ala Gly Ala Gly Asp Thr Ala Glu
             100                 105                 110        
 Pro Gly Asn Glu Ser Gly His Arg Arg Gly His His Asp Ser Ser Ala
         115                 120                 125            
 Ala Trp Ser Pro Cys Trp Phe Thr Val Leu Gly Ser Tyr
     130                 135                 140    



      <210> 742
      <211> 306
      <212> PRT
      <213> Homo sapiens


      <400> 742
 Met Tyr His Ser Ala Glu His Gly Tyr Val Asp Val Thr Ile Asp Ile
   1               5                  10                  15    
 Arg Ser Ile Gly Val Pro Trp Thr Leu His Thr Trp Leu Glu Ser Leu
              20                  25                  30        
 Arg Ile Ala Phe Gln Gln His Arg Arg Pro Leu Ile Gln Cys Leu Leu
          35                  40                  45            
 Lys Glu Phe Lys Thr Ile Gln Glu Glu Glu Tyr Thr Glu Glu Leu Val
      50                  55                  60                
 Thr Gln Gly Leu Pro Leu Met Phe Glu Ile Leu Lys Ala Ser Lys Asn
  65                  70                  75                  80
 Glu Val Ile Ser Gln Gln Leu Cys Val Ile Phe Thr His Cys Tyr Gly
                  85                  90                  95    
 Pro Tyr Pro Ile Pro Lys Leu Thr Glu Ile Lys Arg Lys Gln Thr Ser
             100                 105                 110        
 Arg Leu Asp Pro His Phe Leu Asn Asn Lys Glu Met Ser Asp Val Thr
         115                 120                 125            
 Phe Leu Val Glu Gly Arg Pro Phe Tyr Ala His Lys Val Leu Leu Phe
     130                 135                 140                
 Thr Ala Ser Pro Arg Phe Lys Ala Leu Leu Ser Ser Lys Pro Thr Asn
 145                 150                 155                 160
 Asp Gly Thr Cys Ile Glu Ile Gly Tyr Val Lys Tyr Ser Ile Phe Gln
                 165                 170                 175    
 Leu Val Met Gln Tyr Leu Tyr Tyr Gly Gly Pro Glu Ser Leu Leu Ile
             180                 185                 190        
 Lys Asn Asn Glu Ile Met Glu Leu Leu Ser Ala Ala Lys Phe Phe Gln
         195                 200                 205            
 Leu Glu Ala Leu Gln Arg His Cys Glu Ile Ile Cys Ala Lys Ser Ile
     210                 215                 220                
 Asn Thr Asp Asn Cys Val Asp Ile Tyr Asn His Ala Lys Phe Leu Gly
 225                 230                 235                 240
 Val Thr Glu Leu Ser Ala Tyr Cys Glu Gly Tyr Phe Leu Lys Asn Met
                 245                 250                 255    
 Met Val Leu Ile Glu Asn Glu Ala Phe Lys Gln Leu Leu Tyr Asp Lys
             260                 265                 270        
 Asn Gly Glu Gly Thr Gly Gln Asp Val Leu Gln Asp Leu Gln Arg Thr
         275                 280                 285            
 Leu Ala Ile Arg Ile Gln Ser Ile His Leu Ser Ser Ser Lys Gly Ser
     290                 295                 300                
 Val Val
 305    



      <210> 743
      <211> 288
      <212> PRT
      <213> Homo sapiens


      <400> 743
 Met Phe Ser Phe Asn Met Phe Asn His Leu Ile Pro Arg Val Phe Gln
   1               5                  10                  15    
 Asn Arg Phe Ser Thr His Tyr Arg Cys Phe Ser Val Ser Thr Leu Ala
              20                  25                  30        
 Gly Pro Asn Asp Lys Ser Asp Val Glu Lys Gly Gly Lys Ile Ile Met
          35                  40                  45            
 Leu Pro Ser Ala Leu Asp Gln Leu Ser Gln Leu Asn Ile Thr Tyr Pro
      50                  55                  60                
 Met Leu Phe Lys Leu Thr Ser Lys Asn Leu Asp Arg Met Thr His Cys
  65                  70                  75                  80
 Gly Val Leu Glu Phe Val Ala Asp Glu Gly Ile Cys Tyr Leu Pro His
                  85                  90                  95    
 Trp Met Met Gln Asn Leu Leu Leu Glu Glu Gly Ser Leu Pro Gln Ser
             100                 105                 110        
 Pro Asp Ile Leu Asp Ile Thr Asn Pro Lys Ala Val Leu Asp Asn Ala
         115                 120                 125            
 Leu Arg Asn Phe Ala Cys Leu Thr Thr Gly Asn Val Thr Ala Ile Asn
     130                 135                 140                
 Cys Asn Glu Lys Ile Tyr Glu Leu Glu Leu Arg Val Met Glu Thr Lys
 145                 150                 155                 160
 Pro Asn Lys Ala Val Ser Ile Thr Glu Cys Asp Thr Asn Val Asp Ser
                 165                 170                 175    
 Asp Ala Pro Leu Gly Tyr Lys Glu Pro Glu Arg Gln Val Gln His Glu
             180                 185                 190        
 Glu Leu Thr Glu Gly Glu Ala Asp His Ser Gly Tyr Ala Gly Glu Leu
         195                 200                 205            
 Gly Phe Arg Ala Phe Ser Gly Ser Gly Asn Arg Leu Asp Gly Lys Lys
     210                 215                 220                
 Glu Ser Pro Ser Pro Ile Lys Pro Gly Asp Ile Lys Arg Gly Ile Pro
 225                 230                 235                 240
 Asn His Glu Phe Lys Leu Gly Lys Thr Pro Phe Ile Arg Asn Ala Cys
                 245                 250                 255    
 Pro Leu Val Lys Lys Phe Glu Glu Asp Glu Ala Gly Gly Arg Phe Val
             260                 265                 270        
 Ala Phe Ser Gly Glu Gly Gln Ser Leu Ser Lys Lys Gly Arg Lys Pro
         275                 280                 285            





      <210> 744
      <211> 69
      <212> PRT
      <213> Homo sapiens


      <400> 744
 Met Glu Glu Glu Ser Thr His Lys Glu Lys Leu Glu Ala Leu His Pro
   1               5                  10                  15    
 Glu Pro Asn Pro Lys Lys Ser Pro Ala Lys Glu Arg Glu Glu Val Pro
              20                  25                  30        
 Lys Lys Lys Lys Glu Asn Ala Asp Thr Gly Arg Glu Gly Asn Asn Pro
          35                  40                  45            
 Ala Glu Asn Glu Asp Ala Lys Thr Asp Gln Ala Gln Lys Ala Glu Gly
      50                  55                  60                
 Ala Gly Asp Ala Lys
  65                



      <210> 745
      <211> 299
      <212> PRT
      <213> Homo sapiens


      <400> 745
 Met Asn Ile Val Phe Ser Arg Asp Ser Gln Val Arg Val Met Glu Asn
   1               5                  10                  15    
 Thr Val Ala Asn Thr Glu Lys Tyr Phe Gly Gln Phe Cys Ser Leu Leu
              20                  25                  30        
 Ala Ala Tyr Thr Arg Lys Thr Ala Arg Leu Arg Asp Lys Ala Asp Gln
          35                  40                  45            
 Leu Val Lys Gln Leu Ile Asp Phe Ala Asn Ser Glu Asn Pro Glu Leu
      50                  55                  60                
 Arg Ala Thr Met Arg Gly Phe Ala Glu Asp Leu Ala Lys Val Gln Asp
  65                  70                  75                  80
 Tyr Arg Gln Ala Gln Val Glu Arg Leu Glu Thr Lys Val Val Asn Pro
                  85                  90                  95    
 Leu Lys Leu Tyr Gly Ala Gln Ile Lys Gln Thr Arg Ala Glu Ile Lys
             100                 105                 110        
 Lys Phe Lys His Val Gln Asn His Glu Ile Lys Gln Leu Glu Lys Leu
         115                 120                 125            
 Glu Lys Leu Arg Gln Lys Ser Pro Ser Asp Gln Gln Met Ile Ser Gln
     130                 135                 140                
 Ala Glu Thr Arg Val Gln Arg Ala Ala Val Asp Ser Ser Arg Thr Thr
 145                 150                 155                 160
 Leu Gln Leu Glu Glu Thr Val Asp Gly Phe Gln Arg Gln Lys Leu Lys
                 165                 170                 175    
 Asp Leu Gln Lys Phe Phe Cys Asp Phe Val Thr Ile Glu Met Val Phe
             180                 185                 190        
 His Ala Lys Ala Val Glu Val Tyr Ser Ser Ala Phe Gln Thr Leu Glu
         195                 200                 205            
 Lys Tyr Asp Leu Glu Arg Asp Leu Leu Asp Phe Arg Ala Lys Met Gln
     210                 215                 220                
 Gly Val Tyr Gly His Tyr Asp Thr Arg Leu Leu Ala Asn Thr Ser Pro
 225                 230                 235                 240
 Pro Pro Ser Val Leu Gln Ser Leu Ala Ser Gln Ser Ala Gln Ser Thr
                 245                 250                 255    
 Ile Trp Ser Pro Gly Lys Glu Gly Glu Glu Ser Glu Asp Asn Ser Met
             260                 265                 270        
 Glu Glu Ala Pro Val Glu Asp Leu Arg Ala Leu Gly Gln Gly Pro His
         275                 280                 285            
 Lys Arg Glu Leu Pro Thr Thr Val Arg Arg Thr
     290                 295                



      <210> 746
      <211> 99
      <212> PRT
      <213> Homo sapiens


      <400> 746
 Met Thr Lys Lys Arg Arg Asn Asn Gly Arg Ala Lys Lys Gly Arg Gly
   1               5                  10                  15    
 His Val Gln Pro Ile Arg Cys Thr Asn Cys Ala Arg Cys Met Pro Lys
              20                  25                  30        
 Asp Lys Ala Ile Lys Lys Phe Ile Ile Arg Asn Ile Val Glu Ala Ala
          35                  40                  45            
 Ala Ile Arg Asp Ile Ser Glu Ala Ser Val Phe Asp Ala Asn Glu Leu
      50                  55                  60                
 Pro Lys Leu Tyr Val Lys Leu Pro Tyr Cys Val Ser Cys Ala Ile His
  65                  70                  75                  80
 Ser Lys Val Val Arg Asn Arg Ser His Glu Ala Arg Lys Asp Arg Thr
                  85                  90                  95    
 Pro Pro Pro
            



      <210> 747
      <211> 202
      <212> PRT
      <213> Homo sapiens


      <400> 747
 Met Ser Ser Gly Tyr Ser Ser Leu Glu Glu Asp Ala Glu Asp Phe Phe
   1               5                  10                  15    
 Phe Thr Ala Arg Thr Ser Phe Phe Arg Arg Ala Pro Gln Gly Lys Pro
              20                  25                  30        
 Arg Ser Gly Gln Gln Asn Ser Asn Gly Ile Tyr Thr Gly Phe Ile Lys
          35                  40                  45            
 Val Gln Met Glu Leu Cys Lys Pro Pro Gln Thr Ser Pro Asn Ser Gly
      50                  55                  60                
 Lys Leu Ser Pro Ser Ser Asn Gly Cys Met Asn Thr Leu His Ile Ser
  65                  70                  75                  80
 Ser Thr Asn Thr Val Gly Glu Val Ile Glu Ala Leu Leu Lys Lys Phe
                  85                  90                  95    
 Leu Val Thr Glu Ser Pro Ala Lys Phe Ala Leu Tyr Lys Arg Cys His
             100                 105                 110        
 Arg Glu Asp Gln Val Tyr Ala Cys Lys Leu Ser Asp Arg Glu His Pro
         115                 120                 125            
 Leu Tyr Leu Arg Leu Val Ala Gly Pro Arg Thr Asp Thr Leu Ser Phe
     130                 135                 140                
 Val Leu Arg Glu His Glu Ile Gly Glu Trp Glu Ala Phe Ser Leu Pro
 145                 150                 155                 160
 Glu Leu Gln Asn Phe Leu Arg Ile Leu Asp Lys Glu Glu Asp Glu Gln
                 165                 170                 175    
 Leu Gln Asn Leu Lys Arg Arg Tyr Thr Ala Tyr Arg Gln Lys Leu Glu
             180                 185                 190        
 Glu Ala Leu Arg Glu Val Trp Lys Pro Asp
         195                 200        



      <210> 748
      <211> 340
      <212> PRT
      <213> Homo sapiens


      <400> 748
 Met Ser Leu His Gln Phe Leu Leu Glu Pro Ile Thr Cys His Ala Trp
   1               5                  10                  15    
 Asn Arg Asp Arg Thr Gln Ile Ala Leu Ser Pro Asn Asn His Glu Val
              20                  25                  30        
 His Ile Tyr Lys Lys Asn Gly Ser Gln Trp Val Lys Ala His Glu Leu
          35                  40                  45            
 Lys Glu His Asn Gly His Ile Thr Gly Ile Asp Trp Ala Pro Lys Ser
      50                  55                  60                
 Asp Arg Ile Val Thr Cys Gly Ala Asp Arg Asn Ala Tyr Val Trp Ser
  65                  70                  75                  80
 Gln Lys Asp Gly Val Trp Lys Pro Thr Leu Val Ile Leu Arg Ile Asn
                  85                  90                  95    
 Arg Ala Ala Thr Phe Val Lys Trp Ser Pro Leu Glu Asn Lys Phe Ala
             100                 105                 110        
 Val Gly Ile Leu Ser Leu Asp Trp His Pro Asn Asn Val Leu Leu Ala
         115                 120                 125            
 Ala Gly Ser Cys Asp Phe Lys Cys Arg Val Phe Ser Ala Tyr Ile Lys
     130                 135                 140                
 Glu Val Asp Glu Lys Pro Ala Ser Met Pro Trp Gly Ser Lys Met Pro
 145                 150                 155                 160
 Phe Gly Gln Leu Met Ser Glu Phe Gly Gly Ser Gly Thr Gly Gly Trp
                 165                 170                 175    
 Val His Gly Val Ser Phe Ser Ala Ser Gly Ser Arg Leu Ala Trp Val
             180                 185                 190        
 Ser His Asp Ser Thr Val Ser Val Ala Asp Ala Ser Lys Ser Val Gln
         195                 200                 205            
 Val Ser Thr Leu Lys Thr Glu Phe Leu Pro Leu Leu Ser Val Ser Phe
     210                 215                 220                
 Val Ser Glu Asn Ser Val Val Ala Ala Gly His Asp Cys Cys Pro Met
 225                 230                 235                 240
 Leu Phe Asn Tyr Asp Asp Arg Gly Cys Leu Thr Phe Val Ser Lys Leu
                 245                 250                 255    
 Asp Ile Pro Lys Gln Ser Ile Gln Arg Asn Met Ser Ala Met Glu Arg
             260                 265                 270        
 Phe Arg Asn Met Asp Lys Arg Ala Thr Thr Glu Asp Arg Asn Thr Ala
         275                 280                 285            
 Leu Glu Thr Leu His Gln Asn Ser Ile Thr Gln Val Ser Ile Tyr Glu
     290                 295                 300                
 Val Asp Lys Gln Asp Cys Arg Lys Phe Cys Thr Thr Gly Ile Asp Gly
 305                 310                 315                 320
 Ala Met Thr Ile Trp Asp Phe Lys Thr Leu Glu Ser Ser Ile Gln Gly
                 325                 330                 335    
 Leu Arg Ile Met
             340



      <210> 749
      <211> 178
      <212> PRT
      <213> Homo sapiens


      <400> 749
 Met Leu Gly Glu Ser Arg Ser Gln Asp Ser Arg Gly Pro His Thr Pro
   1               5                  10                  15    
 Arg Pro Ala Gln Pro Thr Cys Ala Ala Ala Met Ser Leu Val Ile Pro
              20                  25                  30        
 Glu Lys Phe Gln His Ile Leu Arg Val Leu Asn Thr Asn Ile Asp Gly
          35                  40                  45            
 Arg Arg Lys Ile Ala Phe Ala Ile Thr Ala Ile Lys Gly Val Gly Arg
      50                  55                  60                
 Arg Tyr Ala His Val Val Leu Arg Lys Ala Asp Ile Asp Leu Thr Lys
  65                  70                  75                  80
 Arg Ala Gly Glu Leu Thr Glu Asp Glu Val Glu Arg Val Ile Thr Ile
                  85                  90                  95    
 Met Gln Asn Pro Arg Gln Tyr Lys Ile Pro Asp Trp Phe Leu Asn Arg
             100                 105                 110        
 Gln Lys Asp Val Lys Asp Gly Lys Tyr Ser Gln Val Leu Ala Asn Gly
         115                 120                 125            
 Leu Asp Asn Lys Leu Arg Glu Asp Leu Glu Arg Leu Lys Lys Ile Arg
     130                 135                 140                
 Ala His Arg Gly Leu Arg His Phe Trp Gly Leu Arg Val Arg Gly Gln
 145                 150                 155                 160
 His Thr Lys Thr Thr Gly Arg Arg Gly Arg Thr Val Gly Val Ser Lys
                 165                 170                 175    
 Lys Lys
        



      <210> 750
      <211> 190
      <212> PRT
      <213> Homo sapiens


      <400> 750
 Met Glu Lys Val Pro Gly Glu Met Glu Ile Glu Arg Arg Glu Arg Ser
   1               5                  10                  15    
 Glu Glu Leu Ser Glu Ala Glu Arg Lys Ala Val Gln Ala Met Trp Ala
              20                  25                  30        
 Arg Leu Tyr Ala Asn Cys Glu Asp Val Gly Val Ala Ile Leu Val Arg
          35                  40                  45            
 Phe Phe Val Asn Phe Pro Ser Ala Lys Gln Tyr Phe Ser Gln Phe Lys
      50                  55                  60                
 His Met Glu Asp Pro Leu Glu Met Glu Arg Ser Pro Gln Leu Arg Lys
  65                  70                  75                  80
 His Ala Cys Arg Val Met Gly Ala Leu Asn Thr Val Val Glu Asn Leu
                  85                  90                  95    
 His Asp Pro Asp Lys Val Ser Ser Val Leu Ala Leu Val Gly Lys Ala
             100                 105                 110        
 His Ala Leu Lys His Lys Val Glu Pro Val Tyr Phe Lys Ile Leu Ser
         115                 120                 125            
 Gly Val Ile Leu Glu Val Val Ala Glu Glu Phe Ala Ser Asp Phe Pro
     130                 135                 140                
 Pro Glu Thr Gln Arg Ala Trp Ala Lys Leu Arg Gly Leu Ile Tyr Ser
 145                 150                 155                 160
 His Val Thr Ala Ala Tyr Lys Glu Val Gly Trp Val Gln Gln Val Pro
                 165                 170                 175    
 Asn Ala Thr Thr Pro Pro Ala Thr Leu Pro Ser Ser Gly Pro
             180                 185                 190



      <210> 751
      <211> 575
      <212> PRT
      <213> Homo sapiens


      <400> 751
 Met Asp Pro Phe His Ala Cys Ser Ile Leu Lys Gln Leu Lys Thr Met
   1               5                  10                  15    
 Tyr Asp Glu Gly Gln Leu Thr Asp Ile Val Val Glu Val Asp His Gly
              20                  25                  30        
 Lys Thr Phe Ser Cys His Arg Asn Val Leu Ala Ala Ile Ser Pro Tyr
          35                  40                  45            
 Phe Arg Ser Met Phe Thr Ser Gly Leu Thr Glu Ser Thr Gln Lys Glu
      50                  55                  60                
 Val Arg Ile Val Gly Val Glu Ala Glu Ser Met Asp Leu Val Leu Asn
  65                  70                  75                  80
 Tyr Ala Tyr Thr Ser Arg Val Ile Leu Thr Glu Ala Asn Val Gln Ala
                  85                  90                  95    
 Leu Phe Thr Ala Ala Ser Ile Phe Gln Ile Pro Ser Ile Gln Asp Gln
             100                 105                 110        
 Cys Ala Lys Tyr Met Ile Ser His Leu Asp Pro Gln Asn Ser Ile Gly
         115                 120                 125            
 Val Phe Ile Phe Ala Asp His Tyr Gly His Gln Glu Leu Gly Asp Arg
     130                 135                 140                
 Ser Lys Glu Tyr Ile Arg Lys Lys Phe Leu Cys Val Thr Lys Glu Gln
 145                 150                 155                 160
 Glu Phe Leu Gln Leu Thr Lys Asp Gln Leu Ile Ser Ile Leu Asp Ser
                 165                 170                 175    
 Asp Asp Leu Asn Val Asp Arg Glu Glu His Val Tyr Glu Ser Ile Ile
             180                 185                 190        
 Arg Trp Phe Glu His Glu Gln Asn Glu Arg Glu Val His Leu Pro Glu
         195                 200                 205            
 Ile Phe Ala Lys Cys Ile Arg Phe Pro Leu Met Glu Asp Thr Phe Ile
     210                 215                 220                
 Glu Lys Ile Pro Pro Gln Phe Ala Gln Ala Ile Ala Lys Ser Cys Val
 225                 230                 235                 240
 Glu Lys Gly Pro Ser Asn Thr Asn Gly Cys Thr Gln Arg Leu Gly Met
                 245                 250                 255    
 Thr Ala Ser Glu Met Ile Ile Cys Phe Asp Ala Ala His Lys His Ser
             260                 265                 270        
 Gly Lys Lys Gln Thr Val Pro Cys Leu Asp Ile Val Thr Gly Arg Val
         275                 280                 285            
 Phe Lys Leu Cys Lys Pro Pro Asn Asp Leu Arg Glu Val Gly Ile Leu
     290                 295                 300                
 Val Ser Pro Asp Asn Asp Ile Tyr Ile Ala Gly Gly Tyr Arg Pro Ser
 305                 310                 315                 320
 Ser Ser Glu Val Ser Ile Asp His Lys Ala Glu Asn Asp Phe Trp Met
                 325                 330                 335    
 Tyr Asp His Ser Thr Asn Arg Trp Leu Ser Lys Pro Ser Leu Leu Arg
             340                 345                 350        
 Ala Arg Ile Gly Cys Lys Leu Val Tyr Cys Cys Gly Lys Met Tyr Ala
         355                 360                 365            
 Ile Gly Gly Arg Val Tyr Glu Gly Asp Gly Arg Asn Ser Leu Lys Ser
     370                 375                 380                
 Val Glu Cys Tyr Asp Ser Arg Glu Asn Arg Trp Thr Thr Val Cys Ala
 385                 390                 395                 400
 Met Pro Val Ala Met Glu Phe His Asn Ala Val Glu Tyr Lys Glu Lys
                 405                 410                 415    
 Ile Tyr Val Leu Gln Gly Glu Phe Phe Leu Phe Tyr Glu Pro Gln Lys
             420                 425                 430        
 Asp Tyr Trp Gly Phe Leu Thr Pro Met Thr Val Pro Arg Ile Gln Gly
         435                 440                 445            
 Leu Ala Ala Val Tyr Lys Asp Ser Ile Tyr Tyr Ile Ala Gly Thr Cys
     450                 455                 460                
 Gly Asn His Gln Arg Met Phe Thr Val Glu Ala Tyr Asp Ile Glu Leu
 465                 470                 475                 480
 Asn Lys Trp Thr Arg Lys Lys Asp Phe Pro Cys Asp Gln Ser Ile Asn
                 485                 490                 495    
 Pro Tyr Leu Lys Leu Val Leu Phe Gln Asn Lys Leu His Leu Phe Val
             500                 505                 510        
 Arg Ala Thr Gln Val Thr Val Glu Glu His Val Phe Arg Thr Ser Arg
         515                 520                 525            
 Lys Asn Ser Leu Tyr Gln Tyr Asp Asp Ile Ala Asp Gln Trp Met Lys
     530                 535                 540                
 Val Tyr Glu Thr Pro Asp Arg Leu Trp Asp Leu Gly Arg His Phe Glu
 545                 550                 555                 560
 Cys Ala Val Ala Lys Leu Tyr Pro Gln Cys Leu Gln Lys Val Leu
                 565                 570                 575



      <210> 752
      <211> 407
      <212> PRT
      <213> Homo sapiens


      <400> 752
 Met Glu Gly Pro Ala Glu Trp Gly Pro Glu Ala Ala Leu Gly Pro Glu
   1               5                  10                  15    
 Ala Val Leu Arg Phe Leu Ala Glu Arg Gly Gly Arg Ala Leu His Ala
              20                  25                  30        
 Glu Leu Val Gln His Phe Arg Gly Ala Leu Gly Gly Glu Pro Glu Gln
          35                  40                  45            
 Arg Ala Arg Ala Arg Ala His Phe Lys Glu Leu Val Asn Ala Val Ala
      50                  55                  60                
 Thr Val Arg Val Asp Pro Ala Asp Gly Ala Lys Tyr Val His Leu Lys
  65                  70                  75                  80
 Lys Arg Phe Cys Glu Gly Pro Ser Glu Pro Ser Gly Asp Pro Pro Arg
                  85                  90                  95    
 Ile Gln Val Thr Ala Glu Pro Glu Ala Pro Asp Gly Pro Ala Gly Pro
             100                 105                 110        
 Glu Ala Arg Asp Arg Leu Pro Asp Ala Ala Ala Pro Glu Ser Leu Pro
         115                 120                 125            
 Gly Gln Gly Arg Glu Leu Gly Glu Gly Glu Pro Pro Ala Pro Ala His
     130                 135                 140                
 Trp Pro Pro Leu Ser Ala Gly Ala Arg Arg Lys Asn Ser Arg Arg Asp
 145                 150                 155                 160
 Val Gln Pro Leu Pro Arg Thr Pro Ala Pro Gly Pro Ser Glu Asp Leu
                 165                 170                 175    
 Glu Leu Pro Pro His Gly Cys Glu Glu Ala Asp Arg Gly Ser Ser Leu
             180                 185                 190        
 Val Gly Ala Thr Ala Gln Arg Pro Ala Arg Gln Asn Leu Arg Asp Leu
         195                 200                 205            
 Val Met Gly Ser Ser Pro Gln Leu Lys Arg Ser Val Cys Pro Gly Gly
     210                 215                 220                
 Ser Ser Pro Gly Ser Ser Ser Gly Gly Gly Arg Gly Arg Gly Gly Gly
 225                 230                 235                 240
 Asp Ser Asp Ser Ala Ser Val Ala Ser Ser Ser Ala Glu Glu Glu Ser
                 245                 250                 255    
 Ser Gly Gly Gly Ser Val Thr Leu Asp Pro Leu Glu His Ala Trp Met
             260                 265                 270        
 Leu Ser Ala Ser Asp Gly Lys Trp Asp Ser Leu Glu Ala Pro Gly Glu
         275                 280                 285            
 His Arg Arg Gln Asp Glu Arg Gly Tyr Thr Ala Leu His Leu Ala Ala
     290                 295                 300                
 Met His Gly His Val Glu Val Val Lys Leu Leu Val Gly Ala Tyr Asp
 305                 310                 315                 320
 Ala Asp Val Asp Ile Arg Asp Tyr Ser Gly Lys Lys Ala Ser Gln Tyr
                 325                 330                 335    
 Leu Ser Arg Ser Ile Ala Glu Glu Ile Lys Asn Leu Val Gly Ala Leu
             340                 345                 350        
 Asp Glu Gly Asp Gly Glu Arg Pro Arg Val Ala Ala Ala Gly Ala Gly
         355                 360                 365            
 Gly Phe Gln Arg Gly Phe Gln Lys Ser Asp Glu Gln Asp Asp Gly Asp
     370                 375                 380                
 Asp Asp Ser Cys Tyr Ser Leu Pro Gln Leu Ala Ser Trp Ser Val Tyr
 385                 390                 395                 400
 Lys Met Ala Leu Ala Met Arg
                 405        



      <210> 753
      <211> 292
      <212> PRT
      <213> Homo sapiens


      <400> 753
 Met Arg Glu Ser Asp Asn Pro Gly Thr Gly Pro Trp Val Thr Thr Val
   1               5                  10                  15    
 Ala Ala Gly Asn Gln Pro Thr Leu Ile Ala His Ser Tyr Gly Val Ala
              20                  25                  30        
 Gln Pro Pro Thr Phe Ser Pro Ala Val Asn Val Gln Ala Pro Val Ile
          35                  40                  45            
 Gly Val Thr Pro Ser Leu Pro Pro His Val Gly Pro Gln Leu Pro Leu
      50                  55                  60                
 Met Pro Gly His Tyr Ser Leu Pro Gln Pro Pro Ser Gln Pro Leu Ser
  65                  70                  75                  80
 Ser Val Val Val Asn Met Pro Ala Gln Ala Leu Tyr Ala Ser Pro Gln
                  85                  90                  95    
 Pro Leu Ala Val Ser Thr Leu Pro Gly Val Gly Gln Val Ala Arg Pro
             100                 105                 110        
 Gly Pro Thr Ala Val Gly Asn Gly His Met Ala Gly Pro Leu Leu Pro
         115                 120                 125            
 Pro Pro Pro Pro Ala Gln Pro Ser Ala Thr Leu Pro Ser Gly Ala Pro
     130                 135                 140                
 Ala Thr Asn Gly Pro Pro Thr Thr Asp Ser Ala His Gly Leu Gln Met
 145                 150                 155                 160
 Leu Arg Thr Ile Gly Val Gly Lys Tyr Glu Phe Thr Asp Pro Gly His
                 165                 170                 175    
 Pro Arg Gly Lys Ser Cys Cys His Val Pro Pro His Gly Pro Ala Ser
             180                 185                 190        
 Ala Pro Pro Cys Ala Val Thr Ala Thr Pro Pro Gly Gln Gly Val Leu
         195                 200                 205            
 His Ala Ser Ser Phe Thr Gly Leu Pro Asn Pro Glu Ala Ala Val Glu
     210                 215                 220                
 Pro Pro Pro Ala Gln Asp Asn Trp Pro Glu Met Gly Glu Gly Gly Gly
 225                 230                 235                 240
 Arg Cys Gly Gly Arg Asp Lys Gln Ser Gly Lys Met Arg Arg Gly Lys
                 245                 250                 255    
 Lys Arg Lys Glu Gly Arg Ala Cys Lys Ala Gln Ser Pro Ser Pro Ser
             260                 265                 270        
 Ser Pro Ser Pro Gly His Ser His Leu Gln Pro Pro Arg Pro Gly Gln
         275                 280                 285            
 Ala Ala Lys Gly
     290        



      <210> 754
      <211> 468
      <212> PRT
      <213> Homo sapiens


      <400> 754
 Met Tyr Arg Tyr Leu Gly Glu Ala Leu Leu Leu Ser Arg Ala Gly Pro
   1               5                  10                  15    
 Ala Ala Leu Gly Ser Ala Ser Ala Asp Ser Ala Ala Leu Leu Gly Trp
              20                  25                  30        
 Ala Arg Gly Gln Pro Ala Ala Ala Pro Gln Pro Gly Leu Ala Leu Ala
          35                  40                  45            
 Ala Arg Arg His Tyr Ser Glu Ala Val Ala Asp Arg Glu Asp Asp Pro
      50                  55                  60                
 Asn Phe Phe Lys Met Val Glu Gly Phe Phe Asp Arg Gly Ala Ser Ile
  65                  70                  75                  80
 Val Glu Asp Lys Leu Val Glu Asp Leu Arg Thr Arg Glu Ser Glu Glu
                  85                  90                  95    
 Gln Lys Arg Asn Arg Leu Leu His Val Pro Glu Ala Val Arg Phe Val
             100                 105                 110        
 Cys Val Lys Asp Leu Lys Gly Thr Asp Val Ser Val Asp Glu Val Lys
         115                 120                 125            
 Ala Leu Ala Ser Leu Met Thr Tyr Lys Cys Ala Val Val Asp Val Pro
     130                 135                 140                
 Phe Gly Gly Ala Lys Ala Gly Val Lys Ile Asn Pro Lys Asn Tyr Thr
 145                 150                 155                 160
 Asp Asn Glu Leu Glu Lys Ile Thr Arg Arg Phe Thr Met Glu Leu Ala
                 165                 170                 175    
 Lys Lys Gly Phe Ile Gly Pro Gly Ile Asp Val Pro Ala Pro Asp Met
             180                 185                 190        
 Ser Thr Gly Glu Arg Glu Met Ser Trp Ile Ala Asp Thr Tyr Ala Ser
         195                 200                 205            
 Thr Ile Gly His Tyr Asp Ile Asn Ala His Ala Cys Val Thr Gly Lys
     210                 215                 220                
 Pro Ile Ser Gln Gly Gly Ile His Gly Arg Ile Ser Ala Thr Gly Arg
 225                 230                 235                 240
 Gly Val Phe His Gly Ile Glu Asn Phe Ile Asn Glu Ala Ser Tyr Met
                 245                 250                 255    
 Ser Ile Leu Gly Met Thr Pro Gly Phe Gly Asp Lys Thr Phe Val Val
             260                 265                 270        
 Gln Ala Lys Pro Tyr Glu Gly Ser Ile Leu Glu Ala Asp Cys Asp Ile
         275                 280                 285            
 Leu Ile Pro Ala Ala Ser Glu Lys Gln Leu Thr Lys Ser Asn Ala Pro
     290                 295                 300                
 Arg Val Lys Ala Lys Ile Ile Ala Glu Gly Ala Asn Gly Pro Thr Thr
 305                 310                 315                 320
 Pro Glu Ala Asp Lys Ile Phe Leu Glu Arg Asn Ile Met Val Ile Pro
                 325                 330                 335    
 Asp Leu Tyr Leu Asn Ala Gly Gly Val Thr Val Ser Tyr Phe Glu Trp
             340                 345                 350        
 Leu Lys Asn Leu Asn His Val Ser Tyr Gly Arg Leu Thr Phe Lys Tyr
         355                 360                 365            
 Glu Arg Asp Ser Asn Tyr His Leu Leu Met Ser Val Gln Glu Ser Leu
     370                 375                 380                
 Glu Arg Lys Phe Gly Lys His Gly Gly Thr Ile Pro Ile Val Pro Thr
 385                 390                 395                 400
 Ala Glu Phe Gln Asp Arg Ile Ser Gly Ala Ser Glu Lys Asp Ile Val
                 405                 410                 415    
 His Ser Gly Leu Ala Tyr Thr Met Glu Arg Ser Ala Arg Gln Ile Met
             420                 425                 430        
 Arg Thr Ala Met Lys Tyr Asn Leu Gly Leu Asp Leu Arg Thr Ala Ala
         435                 440                 445            
 Tyr Val Asn Ala Ile Glu Lys Val Phe Lys Val Tyr Asn Glu Ala Gly
     450                 455                 460                
 Val Thr Phe Thr
 465            



      <210> 755
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 755
 Met Leu Gly Ser Arg Tyr Ala Gly Gln Thr Phe Ser Gly Ala Ser Pro
   1               5                  10                  15    
 Arg Gly Val Ser Asp Ala Leu Leu Leu Ala Pro Ser Gly Arg Gln Arg
              20                  25                  30        
 Ser Arg Asp Thr Val Ala Ser Pro Ser Arg Pro Ser Leu Ser Arg Pro
          35                  40                  45            
 Ser Pro Arg Thr Pro Arg Met Thr His Ser Gly Lys Phe Tyr Arg Thr
      50                  55                  60                
 Thr Ser Leu Arg Gln Arg Pro Val Arg Asn Asn Leu Phe Phe Arg Leu
  65                  70                  75                  80
 Pro Thr Thr Gln Thr Gln Ser Gln Ser Thr Gly His Tyr His Pro Pro
                  85                  90                  95    
 Pro Cys Arg Asn Asn Tyr Pro Ala Ser Pro Gln Glu Arg Ala Glu Arg
             100                 105                 110        
 Arg Cys Gln Lys Lys Phe Cys Ser Arg Glu Val Leu Asn Leu Ile Leu
         115                 120                 125            
 Ala Ala Ser Leu Asn Leu Ser Phe Phe Leu Arg Arg Asn Arg Arg Pro
     130                 135                 140                
 Gly Lys
 145    



      <210> 756
      <211> 174
      <212> PRT
      <213> Homo sapiens


      <400> 756
 Met Arg Ile Ala Met Lys Gly Val Pro Glu Gly Thr Ser Leu Ser Ile
   1               5                  10                  15    
 Ser Thr Ser Cys Ser Ser Phe Gln Pro Leu Lys Ile Met Leu Gly Ser
              20                  25                  30        
 Arg Tyr Ala Gly Gln Thr Phe Ser Gly Ala Ser Pro Arg Gly Val Ser
          35                  40                  45            
 Asp Ala Leu Leu Leu Ala Pro Ser Gly Arg Gln Arg Ser Arg Asp Thr
      50                  55                  60                
 Val Ala Ser Pro Ser Arg Pro Ser Leu Ser Arg Pro Ser Pro Arg Thr
  65                  70                  75                  80
 Pro Arg Met Thr His Ser Gly Lys Phe Tyr Arg Thr Thr Ser Leu Arg
                  85                  90                  95    
 Gln Arg Pro Val Arg Asn Asn Leu Phe Phe Arg Leu Pro Thr Thr Gln
             100                 105                 110        
 Thr Gln Ser Gln Ser Thr Gly His Tyr His Pro Pro Pro Cys Arg Asn
         115                 120                 125            
 Asn Tyr Pro Ala Ser Pro Gln Glu Arg Ala Glu Arg Arg Cys Gln Lys
     130                 135                 140                
 Lys Phe Cys Ser Arg Glu Val Leu Asn Leu Ile Leu Ala Ala Ser Leu
 145                 150                 155                 160
 Asn Leu Ser Phe Phe Leu Arg Arg Asn Arg Arg Pro Gly Lys
                 165                 170                



      <210> 757
      <211> 166
      <212> PRT
      <213> Homo sapiens


      <400> 757
 Met Glu Ala Gly Pro His Pro Arg Pro Gly His Cys Cys Lys Pro Gly
   1               5                  10                  15    
 Gly Arg Leu Asp Met Asn His Gly Phe Val His His Ile Arg Arg Asn
              20                  25                  30        
 Gln Ile Ala Arg Asp Asp Tyr Asp Lys Lys Val Lys Gln Ala Ala Lys
          35                  40                  45            
 Glu Lys Val Arg Arg Arg His Thr Pro Ala Pro Thr Arg Pro Arg Lys
      50                  55                  60                
 Pro Asp Leu Gln Val Tyr Leu Pro Arg His Arg Asp Val Ser Ala His
  65                  70                  75                  80
 Pro Arg Asn Pro Asp Tyr Glu Glu Ser Gly Glu Ser Ser Ser Ser Gly
                  85                  90                  95    
 Gly Ser Glu Leu Glu Pro Ser Gly His Gln Leu Phe Cys Leu Glu Tyr
             100                 105                 110        
 Glu Ala Asp Ser Gly Glu Val Thr Ser Val Ile Val Tyr Gln Gly Asp
         115                 120                 125            
 Asp Pro Gly Lys Val Ser Glu Lys Val Ser Ala His Thr Pro Leu Asp
     130                 135                 140                
 Pro Pro Met Arg Glu Ala Leu Lys Leu Arg Ile Gln Glu Glu Ile Ala
 145                 150                 155                 160
 Lys Arg Gln Ser Gln His
                 165    



      <210> 758
      <211> 226
      <212> PRT
      <213> Homo sapiens


      <400> 758
 Met Ala Ala Pro Ala Pro Val Thr Arg Gln Val Ser Gly Ala Ala Ala
   1               5                  10                  15    
 Leu Val Pro Ala Pro Ser Gly Pro Asp Ser Gly Gln Pro Leu Ala Ala
              20                  25                  30        
 Ala Val Ala Glu Leu Pro Val Leu Asp Ala Arg Gly Gln Arg Val Pro
          35                  40                  45            
 Phe Gly Ala Leu Phe Arg Glu Arg Arg Ala Val Val Val Phe Val Arg
      50                  55                  60                
 His Phe Leu Cys Tyr Ile Cys Lys Glu Tyr Val Glu Asp Leu Ala Lys
  65                  70                  75                  80
 Ile Pro Arg Ser Phe Leu Gln Glu Ala Asn Val Thr Leu Ile Val Ile
                  85                  90                  95    
 Gly Gln Ser Ser Tyr His His Ile Glu Pro Phe Cys Lys Leu Thr Gly
             100                 105                 110        
 Tyr Ser His Glu Ile Tyr Val Asp Pro Glu Arg Glu Ile Tyr Lys Arg
         115                 120                 125            
 Leu Gly Met Lys Arg Gly Glu Glu Ile Ala Ser Ser Gly Gln Ser Pro
     130                 135                 140                
 His Ile Lys Ser Asn Leu Leu Ser Gly Ser Leu Gln Ser Leu Trp Arg
 145                 150                 155                 160
 Ala Val Thr Gly Pro Leu Phe Asp Phe Gln Gly Asp Pro Ala Gln Gln
                 165                 170                 175    
 Gly Gly Thr Leu Ile Leu Gly Pro Gly Asn Asn Ile His Phe Ile His
             180                 185                 190        
 Arg Asp Arg Asn Arg Leu Asp His Lys Pro Ile Asn Ser Val Leu Gln
         195                 200                 205            
 Leu Val Gly Val Gln His Val Asn Phe Thr Asn Arg Pro Ser Val Ile
     210                 215                 220                
 His Val
 225    



      <210> 759
      <211> 185
      <212> PRT
      <213> Homo sapiens


      <400> 759
 Met Ala Ala Pro Ala Pro Val Thr Arg Gln Val Ser Gly Ala Ala Ala
   1               5                  10                  15    
 Leu Val Pro Ala Pro Ser Gly Pro Asp Ser Gly Gln Pro Leu Ala Ala
              20                  25                  30        
 Ala Val Ala Glu Leu Pro Val Leu Asp Ala Arg Gly Gln Arg Val Pro
          35                  40                  45            
 Phe Gly Ala Leu Phe Arg Glu Arg Arg Ala Val Val Val Phe Val Arg
      50                  55                  60                
 Pro Phe Cys Lys Leu Thr Gly Tyr Ser His Glu Ile Tyr Val Asp Pro
  65                  70                  75                  80
 Glu Arg Glu Ile Tyr Lys Arg Leu Gly Met Lys Arg Gly Glu Glu Ile
                  85                  90                  95    
 Ala Ser Ser Gly Gln Ser Pro His Ile Lys Ser Asn Leu Leu Ser Gly
             100                 105                 110        
 Ser Leu Gln Ser Leu Trp Arg Ala Val Thr Gly Pro Leu Phe Asp Phe
         115                 120                 125            
 Gln Gly Asp Pro Ala Gln Gln Gly Gly Thr Leu Ile Leu Gly Pro Gly
     130                 135                 140                
 Asn Asn Ile His Phe Ile His Arg Asp Arg Asn Arg Leu Asp His Lys
 145                 150                 155                 160
 Pro Ile Asn Ser Val Leu Gln Leu Val Gly Val Gln His Val Asn Phe
                 165                 170                 175    
 Thr Asn Arg Pro Ser Val Ile His Val
             180                 185



      <210> 760
      <211> 141
      <212> PRT
      <213> Homo sapiens


      <400> 760
 Met Ala Ala Pro Ala Pro Val Thr Arg Gln Val Ser Gly Ala Ala Ala
   1               5                  10                  15    
 Leu Val Pro Ala Pro Ser Gly Pro Asp Ser Gly Gln Pro Leu Ala Ala
              20                  25                  30        
 Ala Val Ala Glu Leu Pro Val Leu Asp Ala Arg Gly Gln Arg Val Pro
          35                  40                  45            
 Phe Gly Ala Leu Phe Arg Glu Arg Arg Ala Val Val Val Phe Val Arg
      50                  55                  60                
 Pro Phe Cys Lys Leu Thr Gly Tyr Ser His Glu Ile Tyr Val Asp Pro
  65                  70                  75                  80
 Glu Arg Glu Ile Tyr Lys Arg Leu Gly Met Lys Arg Gly Glu Glu Ile
                  85                  90                  95    
 Ala Ser Ser Gly Asn Asn Ile His Phe Ile His Arg Asp Arg Asn Arg
             100                 105                 110        
 Leu Asp His Lys Pro Ile Asn Ser Val Leu Gln Leu Val Gly Val Gln
         115                 120                 125            
 His Val Asn Phe Thr Asn Arg Pro Ser Val Ile His Val
     130                 135                 140    



      <210> 761
      <211> 488
      <212> PRT
      <213> Homo sapiens


      <400> 761
 Met Lys Cys Glu His Cys Thr Arg Lys Glu Cys Ser Lys Lys Thr Lys
   1               5                  10                  15    
 Thr Asp Asp Gln Glu Asn Val Ser Ala Asp Ala Pro Ser Pro Ala Gln
              20                  25                  30        
 Glu Asn Gly Glu Lys Gly Glu Phe His Lys Leu Ala Asp Ala Lys Ile
          35                  40                  45            
 Phe Leu Ser Asp Cys Leu Ala Cys Asp Ser Cys Met Thr Ala Glu Glu
      50                  55                  60                
 Gly Val Gln Leu Ser Gln Gln Asn Ala Lys Asp Phe Phe Arg Val Leu
  65                  70                  75                  80
 Asn Leu Asn Lys Lys Cys Asp Thr Ser Lys His Lys Val Leu Val Val
                  85                  90                  95    
 Ser Val Cys Pro Gln Ser Leu Pro Tyr Phe Ala Ala Lys Phe Asn Leu
             100                 105                 110        
 Ser Val Thr Asp Ala Ser Arg Arg Leu Cys Gly Phe Leu Lys Ser Leu
         115                 120                 125            
 Gly Val His Tyr Val Phe Asp Thr Thr Ile Ala Ala Asp Phe Ser Ile
     130                 135                 140                
 Leu Glu Ser Gln Lys Glu Phe Val Arg Arg Tyr Arg Gln His Ser Glu
 145                 150                 155                 160
 Glu Glu Arg Thr Leu Pro Met Leu Thr Ser Ala Cys Pro Gly Trp Val
                 165                 170                 175    
 Arg Tyr Ala Glu Arg Val Leu Gly Arg Pro Ile Thr Ala His Leu Cys
             180                 185                 190        
 Thr Ala Lys Ser Pro Gln Gln Val Met Gly Ser Leu Val Lys Asp Tyr
         195                 200                 205            
 Phe Ala Arg Gln Gln Asn Leu Ser Pro Glu Lys Ile Phe His Val Ile
     210                 215                 220                
 Val Ala Pro Cys Tyr Asp Lys Lys Leu Glu Ala Leu Gln Glu Ser Leu
 225                 230                 235                 240
 Pro Pro Ala Leu His Gly Ser Arg Gly Ala Asp Cys Val Leu Thr Ser
                 245                 250                 255    
 Gly Glu Ile Ala Gln Ile Met Glu Gln Gly Asp Leu Ser Val Arg Asp
             260                 265                 270        
 Ala Ala Val Asp Thr Leu Phe Gly Asp Leu Lys Glu Asp Lys Val Thr
         275                 280                 285            
 Arg His Asp Gly Ala Ser Ser Asp Gly His Leu Ala His Ile Phe Arg
     290                 295                 300                
 His Ala Ala Lys Glu Leu Phe Asn Glu Asp Val Glu Glu Val Thr Tyr
 305                 310                 315                 320
 Arg Ala Leu Arg Asn Lys Asp Phe Gln Glu Val Thr Leu Glu Lys Asn
                 325                 330                 335    
 Gly Glu Val Val Leu Arg Phe Ala Ala Ala Tyr Gly Phe Arg Asn Ile
             340                 345                 350        
 Gln Asn Met Ile Leu Lys Leu Lys Lys Gly Lys Phe Pro Phe His Phe
         355                 360                 365            
 Val Glu Val Leu Ala Cys Ala Gly Gly Cys Leu Asn Gly Arg Gly Gln
     370                 375                 380                
 Ala Gln Thr Pro Asp Gly His Ala Asp Lys Ala Cys Cys Gly Arg Trp
 385                 390                 395                 400
 Lys Ala Phe Thr Leu Thr Ser Leu Cys Gly Val Arg Ser Pro Val His
                 405                 410                 415    
 Thr Cys Arg Ser Cys Thr Arg Ser Gly Trp Arg Gly Ser Thr Pro Pro
             420                 425                 430        
 Arg Pro Glu Arg Cys Cys Ile Pro Arg Thr Arg Ala Arg Ser Val Ala
         435                 440                 445            
 His Thr Ala Trp Thr Ser Ser Gly Glu Val Arg Pro Gly Pro Ser Ser
     450                 455                 460                
 Cys Ser Trp Gly Gln Ser Gln Glu Pro Leu Ser Arg Gly Arg Gly Cys
 465                 470                 475                 480
 Pro Glu Trp Ser Ile Lys Asp Thr
                 485            



      <210> 762
      <211> 105
      <212> PRT
      <213> Homo sapiens


      <400> 762
 Met Arg Asp Leu Trp Asn Trp Val Arg Asn Pro Leu Trp Tyr Ser Gly
   1               5                  10                  15    
 Cys Cys Arg Phe Ser Ser Ser Leu Glu Met Asp Thr Asp Ile Ser Leu
              20                  25                  30        
 Phe Phe Lys Gly Asp Arg Asn His Tyr Val Glu Pro Lys Met Glu Val
          35                  40                  45            
 Ile Ile Asn Ala Ser Trp Arg Leu Trp Val Trp Gly Ile Leu Tyr Leu
      50                  55                  60                
 Asp Ser Val Ser Leu Gln Leu Glu Ala Val Gly Val Gly Asp Ser Val
  65                  70                  75                  80
 Ser Gly Phe Arg Ile Thr Pro Ser Gly Gly Trp Gln Val Phe Leu Gln
                  85                  90                  95    
 Asp Gly Pro Glu Ser Lys Met Ser His
             100                 105



      <210> 763
      <211> 108
      <212> PRT
      <213> Homo sapiens


      <400> 763
 Met Asp Ser Leu Ala Leu Gly Arg Trp Arg Gln Arg Arg Ala Glu Asp
   1               5                  10                  15    
 Leu Gln Val Pro Gly Asp Val Lys Arg Val Cys Arg Arg Leu Glu Ala
              20                  25                  30        
 Ser Gly His Glu Arg Gly Cys His Gln Val Asn Ala Cys Ala Leu Ala
          35                  40                  45            
 Ser Trp Gly Pro Glu Asp Arg Glu Leu Pro Ser Arg Gly Cys Leu Pro
      50                  55                  60                
 Ala Pro Arg Pro Glu Ser Gly Gln Gly Arg Leu Ser Thr Gly Ile Ser
  65                  70                  75                  80
 Gln Asn Gly Gly Arg Ser Ser Ala Gln Pro Cys Pro Arg Cys Ile Ala
                  85                  90                  95    
 Gly Glu Ser Gly His Phe Ser His Thr Lys Asn His
             100                 105            



      <210> 764
      <211> 167
      <212> PRT
      <213> Homo sapiens


      <400> 764
 Met Met Glu Glu Ile Asp Arg Phe Gln Val Pro Thr Ala His Ser Glu
   1               5                  10                  15    
 Met Gln Pro Leu Asp Pro Ala Ala Ala Ser Ile Ser Asp Gly Asp Cys
              20                  25                  30        
 Asp Ala Arg Glu Glu Lys Gln Arg Glu Leu Ala Arg Lys Gly Ser Leu
          35                  40                  45            
 Lys Asn Gly Ser Met Gly Ser Pro Val Asn Gln Gln Pro Lys Lys Asn
      50                  55                  60                
 Asn Val Met Ala Arg Thr Arg Leu Val Val Pro Asn Lys Gly Tyr Ser
  65                  70                  75                  80
 Ser Leu Asp Gln Ser Pro Asp Glu Lys Pro Leu Val Ala Leu Asp Thr
                  85                  90                  95    
 Asp Ser Asp Asp Asp Phe Asp Met Ser Arg Tyr Ser Ser Ser Gly Tyr
             100                 105                 110        
 Ser Ser Ala Glu Ile Asn Gln Asp Leu Asn Ile Gln Leu Leu Lys Asp
         115                 120                 125            
 Gly Tyr Arg Leu Asp Glu Ile Pro Asp Asp Glu Asp Leu Asp Leu Ile
     130                 135                 140                
 Pro Pro Lys Ser Val Asn Pro Thr Cys Met Cys Cys Gln Ala Thr Ser
 145                 150                 155                 160
 Ser Thr Ala Cys His Ile Gln
                 165        



      <210> 765
      <211> 184
      <212> PRT
      <213> Homo sapiens


      <400> 765
 Met Met Glu Glu Ile Asp Arg Phe Gln Val Pro Thr Ala His Ser Glu
   1               5                  10                  15    
 Met Gln Pro Leu Asp Pro Ala Ala Ala Ser Ile Ser Asp Gly Asp Cys
              20                  25                  30        
 Asp Ala Arg Glu Gly Glu Ser Val Ala Met Asn Tyr Lys Pro Ser Pro
          35                  40                  45            
 Leu Gln Val Lys Leu Glu Lys Gln Arg Glu Leu Ala Arg Lys Gly Ser
      50                  55                  60                
 Leu Lys Asn Gly Ser Met Gly Ser Pro Val Asn Gln Gln Pro Lys Lys
  65                  70                  75                  80
 Asn Asn Val Met Ala Arg Thr Arg Leu Val Val Pro Asn Lys Gly Tyr
                  85                  90                  95    
 Ser Ser Leu Asp Gln Ser Pro Asp Glu Lys Pro Leu Val Ala Leu Asp
             100                 105                 110        
 Thr Asp Ser Asp Asp Asp Phe Asp Met Ser Arg Tyr Ser Ser Ser Gly
         115                 120                 125            
 Tyr Ser Ser Ala Glu Ile Asn Gln Asp Leu Asn Ile Gln Leu Leu Lys
     130                 135                 140                
 Asp Gly Tyr Arg Leu Asp Glu Ile Pro Asp Asp Glu Asp Leu Asp Leu
 145                 150                 155                 160
 Ile Pro Pro Lys Ser Val Asn Pro Thr Cys Met Cys Cys Gln Ala Thr
                 165                 170                 175    
 Ser Ser Thr Ala Cys His Ile Gln
             180                



      <210> 766
      <211> 173
      <212> PRT
      <213> Homo sapiens


      <400> 766
 Met Met Glu Glu Ile Asp Arg Phe Gln Asp Pro Ala Ala Ala Ser Ile
   1               5                  10                  15    
 Ser Asp Gly Asp Cys Asp Ala Arg Glu Gly Glu Ser Val Ala Met Asn
              20                  25                  30        
 Tyr Lys Pro Ser Pro Leu Gln Val Lys Leu Glu Lys Gln Arg Glu Leu
          35                  40                  45            
 Ala Arg Lys Gly Ser Leu Lys Asn Gly Ser Met Gly Ser Pro Val Asn
      50                  55                  60                
 Gln Gln Pro Lys Lys Asn Asn Val Met Ala Arg Thr Arg Leu Val Val
  65                  70                  75                  80
 Pro Asn Lys Gly Tyr Ser Ser Leu Asp Gln Ser Pro Asp Glu Lys Pro
                  85                  90                  95    
 Leu Val Ala Leu Asp Thr Asp Ser Asp Asp Asp Phe Asp Met Ser Arg
             100                 105                 110        
 Tyr Ser Ser Ser Gly Tyr Ser Ser Ala Glu Ile Asn Gln Asp Leu Asn
         115                 120                 125            
 Ile Gln Leu Leu Lys Asp Gly Tyr Arg Leu Asp Glu Ile Pro Asp Asp
     130                 135                 140                
 Glu Asp Leu Asp Leu Ile Pro Pro Lys Ser Val Asn Pro Thr Cys Met
 145                 150                 155                 160
 Cys Cys Gln Ala Thr Ser Ser Thr Ala Cys His Ile Gln
                 165                 170            



      <210> 767
      <211> 463
      <212> PRT
      <213> Homo sapiens


      <400> 767
 Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala
   1               5                  10                  15    
 Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys
              20                  25                  30        
 Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr
          35                  40                  45            
 Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr
      50                  55                  60                
 Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met
  65                  70                  75                  80
 Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu
                  85                  90                  95    
 Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr
             100                 105                 110        
 Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Asp Gly Lys Val Glu His
         115                 120                 125            
 Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val
     130                 135                 140                
 Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser Asp Ala
 145                 150                 155                 160
 Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr
                 165                 170                 175    
 Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met
             180                 185                 190        
 Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp
         195                 200                 205            
 Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile
     210                 215                 220                
 Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met
 225                 230                 235                 240
 Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val
                 245                 250                 255    
 Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly
             260                 265                 270        
 Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly
         275                 280                 285            
 Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr
     290                 295                 300                
 Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val
 305                 310                 315                 320
 Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr
                 325                 330                 335    
 Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp
             340                 345                 350        
 Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp
         355                 360                 365            
 Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg
     370                 375                 380                
 Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu
 385                 390                 395                 400
 Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr
                 405                 410                 415    
 Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Met Arg Pro Ser
             420                 425                 430        
 Ser Tyr Ser Ser Glu Ser Ser Leu Ser Thr Ser Lys Pro Thr Ser Cys
         435                 440                 445            
 Thr Cys Asp Gly Trp Pro Pro Pro Gly Ser Trp Ala Cys Gly Asp
     450                 455                 460            



      <210> 768
      <211> 194
      <212> PRT
      <213> Homo sapiens


      <400> 768
 Met Ala Ser Thr Ala Ser Val Pro Lys Thr Asp Lys Glu Leu Ala Val
   1               5                  10                  15    
 Gln Tyr Leu Asn Thr Phe Tyr Gly Cys Pro Lys Glu Ser Cys Asn Leu
              20                  25                  30        
 Phe Val Leu Lys Asp Thr Leu Lys Lys Met Gln Lys Phe Phe Gly Leu
          35                  40                  45            
 Pro Gln Thr Gly Asp Leu Asp Gln Asn Thr Ile Glu Thr Met Arg Lys
      50                  55                  60                
 Pro Arg Cys Gly Asn Pro Asp Val Ala Asn Tyr Asn Phe Phe Pro Arg
  65                  70                  75                  80
 Lys Pro Lys Trp Asp Lys Asn Gln Ile Thr Tyr Arg Ile Ile Gly Tyr
                  85                  90                  95    
 Thr Pro Asp Leu Asp Pro Glu Thr Val Asp Asp Ala Phe Ala Arg Ala
             100                 105                 110        
 Phe Gln Val Trp Ser Asp Val Thr Pro Leu Arg Phe Ser Arg Ile His
         115                 120                 125            
 Asp Gly Glu Ala Asp Ile Met Ile Asn Phe Gly Arg Trp Glu His Gly
     130                 135                 140                
 Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala Phe
 145                 150                 155                 160
 Ala Pro Gly Thr Gly Val Gly Gly Asp Ser Leu Phe Leu Lys Ile Asn
                 165                 170                 175    
 Val Arg Leu Gln Leu Asp Ser Ser Ile Val Pro Ser Arg Arg Ile Pro
             180                 185                 190        
 Glu Val
        



      <210> 769
      <211> 442
      <212> PRT
      <213> Homo sapiens


      <400> 769
 Met Glu Asn Trp Ser Lys Asp Ile Thr His Ser Tyr Leu Glu Gln Glu
   1               5                  10                  15    
 Thr Thr Gly Ile Asn Lys Ser Thr Gln Pro Asp Glu Gln Leu Thr Met
              20                  25                  30        
 Asn Ser Glu Lys Ser Met His Arg Lys Ser Thr Glu Leu Val Asn Glu
          35                  40                  45            
 Ile Thr Cys Glu Asn Thr Glu Trp Pro Gly Gln Arg Ser Thr Asn Phe
      50                  55                  60                
 Gln Ile Ile Ser Ser Tyr Pro Asp Asp Glu Ser Val Tyr Cys Thr Thr
  65                  70                  75                  80
 Glu Lys Tyr Asn Val Met Glu His Arg His Asn Asp Met His Tyr Glu
                  85                  90                  95    
 Cys Met Thr Pro Cys Gln Val Thr Ser Asp Ser Asp Lys Glu Lys Thr
             100                 105                 110        
 Ile Ala Phe Leu Leu Lys Glu Leu Asp Ile Leu Arg Thr Ser Asn Lys
         115                 120                 125            
 Lys Leu Gln Gln Lys Leu Ala Lys Glu Asp Lys Glu Gln Arg Lys Leu
     130                 135                 140                
 Lys Phe Lys Leu Glu Leu Gln Glu Lys Glu Thr Glu Ala Lys Ile Ala
 145                 150                 155                 160
 Glu Lys Thr Ala Ala Leu Val Glu Glu Val Tyr Phe Ala Gln Lys Glu
                 165                 170                 175    
 Arg Asp Glu Ala Val Met Ser Arg Leu Gln Leu Ala Ile Glu Glu Arg
             180                 185                 190        
 Asp Glu Ala Ile Ala Arg Ala Lys His Met Glu Met Ser Leu Lys Val
         195                 200                 205            
 Leu Glu Asn Ile Asn Pro Glu Glu Asn Asp Met Thr Leu Gln Glu Leu
     210                 215                 220                
 Leu Asn Arg Ile Asn Asn Ala Asp Thr Gly Ile Ala Ile Gln Lys Asn
 225                 230                 235                 240
 Gly Ala Ile Ile Val Asp Arg Ile Tyr Lys Thr Lys Glu Cys Lys Met
                 245                 250                 255    
 Arg Ile Thr Ala Glu Glu Met Ser Ala Leu Ile Glu Glu Arg Asp Ala
             260                 265                 270        
 Ala Leu Ser Lys Cys Lys Arg Leu Glu Gln Glu Leu His His Val Lys
         275                 280                 285            
 Glu Gln Asn Gln Thr Ser Ala Asn Asn Met Arg His Leu Thr Ala Glu
     290                 295                 300                
 Asn Asn Gln Glu Arg Ala Leu Lys Ala Lys Leu Leu Ser Met Gln Gln
 305                 310                 315                 320
 Ala Arg Glu Thr Ala Val Gln Gln Tyr Lys Lys Leu Glu Glu Glu Ile
                 325                 330                 335    
 Gln Thr Leu Arg Val Tyr Tyr Ser Leu His Lys Ser Leu Ser Gln Glu
             340                 345                 350        
 Glu Asn Leu Lys Asp Gln Phe Asn Tyr Thr Leu Ser Thr Tyr Glu Glu
         355                 360                 365            
 Ala Leu Lys Asn Arg Glu Asn Ile Val Ser Ile Thr Gln Gln Gln Asn
     370                 375                 380                
 Glu Glu Leu Ala Thr Gln Leu Gln Gln Ala Leu Thr Glu Arg Ala Asn
 385                 390                 395                 400
 Met Glu Leu Gln Leu Gln His Ala Arg Glu Ala Ser Gln Val Ala Asn
                 405                 410                 415    
 Glu Lys Val Gln Lys Leu Glu Arg Leu Val Asp Val Leu Arg Lys Lys
             420                 425                 430        
 Val Gly Thr Gly Thr Met Arg Thr Val Ile
         435                 440        



      <210> 770
      <211> 170
      <212> PRT
      <213> Homo sapiens


      <400> 770
 Met Ala Leu Ser Ala Glu Asp Arg Ala Leu Val Arg Ala Leu Trp Lys
   1               5                  10                  15    
 Lys Leu Gly Ser Asn Val Gly Val Tyr Thr Thr Glu Ala Leu Glu Arg
              20                  25                  30        
 Cys Gly Arg Leu Gly Ala Pro Arg Ala Leu Trp Pro Asn Leu Gly Ser
          35                  40                  45            
 Pro Arg Arg Arg Leu His Asp Arg Gly Pro Gly Lys Thr Phe Leu Ala
      50                  55                  60                
 Phe Pro Ala Thr Lys Thr Tyr Phe Ser His Leu Asp Leu Ser Pro Gly
  65                  70                  75                  80
 Ser Ser Gln Val Arg Ala His Gly Gln Lys Val Ala Asp Ala Leu Ser
                  85                  90                  95    
 Leu Ala Val Glu Arg Leu Asp Asp Leu Pro His Ala Leu Ser Ala Leu
             100                 105                 110        
 Ser His Leu His Ala Cys Gln Leu Arg Val Asp Pro Ala Ser Phe Gln
         115                 120                 125            
 Leu Leu Gly His Cys Leu Leu Val Thr Leu Ala Arg His Tyr Pro Gly
     130                 135                 140                
 Asp Phe Ser Pro Ala Leu Gln Ala Ser Leu Asp Lys Phe Leu Ser His
 145                 150                 155                 160
 Val Ile Ser Ala Leu Val Ser Glu Tyr Arg
                 165                 170



      <210> 771
      <211> 464
      <212> PRT
      <213> Homo sapiens


      <400> 771
 Met Leu Gln Val Pro Cys Pro Thr Glu Ala Asp Ile Ser Gln His Leu
   1               5                  10                  15    
 Thr Asn Arg Glu Val Pro Asn Ser Ser Gln Arg Arg Tyr Thr Gly Lys
              20                  25                  30        
 Val Pro Cys Asn His Phe Thr Leu Asn Glu Glu Glu Asp Cys Phe Lys
          35                  40                  45            
 Ala Leu Ile Trp Ile Arg Asn Asn Ser Ile Thr Thr Glu Gly Asn Ile
      50                  55                  60                
 Ile Val Tyr Gly Asn Thr Ile Asp Thr Tyr Thr Thr Val Glu Thr Leu
  65                  70                  75                  80
 Leu Asn Leu Gly Val Ser Gly Ser Arg Ile His Leu Val Gln Pro Pro
                  85                  90                  95    
 Pro Ala Ser Thr Ile Thr Cys Ile Asn Asn Tyr Ser Val Glu Ser Ala
             100                 105                 110        
 Val Ala Asp Ala Leu Gly Ala Ala Gly Val Thr Met Tyr Arg Asp Ala
         115                 120                 125            
 Ile Leu Ala Gln Trp Asn Asp Gly Leu His Pro Asp Pro Ile Tyr Ser
     130                 135                 140                
 Ala Ser Phe Thr Thr Pro Thr Lys Pro Phe Arg Leu Gln Cys Ser Met
 145                 150                 155                 160
 Phe Phe Ser Phe Cys Glu Lys Asn Val Asp Tyr Glu Thr Phe Lys Ala
                 165                 170                 175    
 Leu Asn Asp Ala Cys Leu Val Tyr Asp Ser Arg Leu Val Ile Asp Thr
             180                 185                 190        
 Asn Phe His Thr Asn Asp Ile Ala Ile Arg Ala Ala Gly Ser Leu Thr
         195                 200                 205            
 Lys Phe Ser Asn Arg Tyr Tyr Ser Asn Glu Trp Thr His Ser Asn Phe
     210                 215                 220                
 Ser Ser Lys Glu Ile Gly Phe Gln Leu Ala Ala Ala Met Leu His Leu
 225                 230                 235                 240
 Phe Asp Pro Thr Leu Glu Pro Val Thr Glu Pro Pro Ala Asn Leu Asp
                 245                 250                 255    
 Arg Leu Ile Pro Met Tyr Lys Gly Ala Lys Ile Gln Gly Gly Ile Leu
             260                 265                 270        
 Pro Gly Ser Tyr His Tyr Leu His Ile Ala Lys Pro Ala Ile Pro Thr
         275                 280                 285            
 Pro Leu Glu Val Gln Met Ala Gln Pro Asn Tyr Gly Leu Glu Leu Val
     290                 295                 300                
 Thr Gly Ser Ala Lys Asn Gly Thr Tyr Phe Arg Ile His Ile Asn Lys
 305                 310                 315                 320
 Tyr Lys Met Val Glu Thr Ile Thr Cys Leu Ser Arg Glu Pro Phe Pro
                 325                 330                 335    
 Ala Ser Asn Tyr Ile Arg Leu Phe Gly Gln His Glu Gln Leu Leu Asn
             340                 345                 350        
 Asn Leu Cys Ala Arg Tyr Asp Glu Asn Leu Ile Thr Asp Leu Tyr Ser
         355                 360                 365            
 Tyr Phe Thr Glu Pro Trp Cys Leu Ala Leu Phe His Asp Arg Phe Ile
     370                 375                 380                
 Asp Leu Arg Lys Glu Leu Arg Gln Ile Leu Ala Ser Lys Glu Glu Glu
 385                 390                 395                 400
 Asp Leu Pro Ser Ile Glu Gln Leu Ala His Gln Ile Glu Asp Glu Glu
                 405                 410                 415    
 Ile Asn Pro Thr Glu Lys Pro Arg Gln Tyr Leu Lys Arg Val Phe Glu
             420                 425                 430        
 Glu Ser Ile Tyr Lys Thr Leu Val Glu Arg Ser Thr Leu Asp Tyr Leu
         435                 440                 445            
 His Tyr Asn Arg Tyr His Leu Pro Met Tyr Ala Trp Pro Gly Ile Val
     450                 455                 460                





      <210> 772
      <211> 132
      <212> PRT
      <213> Homo sapiens


      <400> 772
 Met Arg Glu Gly Gln Glu Met Gly Pro Thr Pro Val Pro Ser Asn Pro
   1               5                  10                  15    
 Leu Phe His Arg Ser Phe Pro Cys Trp Pro Arg Gly Trp Phe His Pro
              20                  25                  30        
 Val Pro Thr Arg Lys Leu Leu Leu Glu Pro Ala Gln Pro Ala Asp Leu
          35                  40                  45            
 Leu Pro Pro Ala Pro Pro Ala Gly Pro Cys Ser Leu Ala Ser Trp Met
      50                  55                  60                
 Leu Ser Gln Pro Gly Arg Gly Ser Gln Val Lys Thr Gly Gly Thr Pro
  65                  70                  75                  80
 Thr Ala Pro Ala Gln Asp Ala Glu Ala Pro Leu Pro Asp Cys Asp Leu
                  85                  90                  95    
 Cys Leu Phe Pro Ala Pro Val Gly Thr Trp Gln Pro Lys Ala Lys Ala
             100                 105                 110        
 Gly Trp Ala Gly Asp Pro Arg Asn Leu Phe Gly Asn Pro Phe Ser Pro
         115                 120                 125            
 Gly Trp Glu Gln
     130        



      <210> 773
      <211> 1044
      <212> PRT
      <213> Homo sapiens


      <400> 773
 Met Glu Gly Gln Ser Ser Arg Gly Ser Arg Arg Pro Gly Thr Arg Ala
   1               5                  10                  15    
 Gly Leu Gly Ser Leu Pro Met Pro Gln Gly Val Ala Gln Thr Gly Ala
              20                  25                  30        
 Pro Ser Lys Val Asp Ser Ser Phe Gln Leu Pro Ala Lys Lys Asn Ala
          35                  40                  45            
 Ala Leu Gly Pro Ser Glu Pro Arg Leu Ala Leu Ala Pro Val Gly Pro
      50                  55                  60                
 Arg Ala Ala Met Ser Ala Ser Ser Glu Gly Pro Arg Leu Ala Leu Ala
  65                  70                  75                  80
 Ser Pro Arg Pro Ile Leu Ala Pro Leu Cys Thr Pro Glu Gly Gln Lys
                  85                  90                  95    
 Thr Ala Thr Ala His Arg Ser Ser Ser Leu Ala Pro Thr Ser Val Gly
             100                 105                 110        
 Gln Leu Val Met Ser Ala Ser Ala Gly Pro Lys Pro Pro Pro Ala Thr
         115                 120                 125            
 Thr Gly Ser Val Leu Ala Pro Thr Ser Leu Gly Leu Val Met Pro Ala
     130                 135                 140                
 Ser Ala Gly Pro Arg Ser Pro Pro Val Thr Leu Gly Pro Asn Leu Ala
 145                 150                 155                 160
 Pro Thr Ser Arg Asp Gln Lys Gln Glu Pro Pro Ala Ser Val Gly Pro
                 165                 170                 175    
 Lys Pro Thr Leu Ala Ala Ser Gly Leu Ser Leu Ala Leu Ala Ser Glu
             180                 185                 190        
 Glu Gln Pro Pro Glu Leu Pro Ser Thr Pro Ser Pro Val Pro Ser Pro
         195                 200                 205            
 Val Leu Ser Pro Thr Gln Glu Gln Ala Leu Ala Pro Ala Ser Thr Ala
     210                 215                 220                
 Ser Gly Ala Ala Ser Val Gly Gln Thr Ser Ala Arg Lys Arg Asp Ala
 225                 230                 235                 240
 Pro Ala Pro Arg Pro Leu Pro Ala Ser Glu Gly His Leu Gln Pro Pro
                 245                 250                 255    
 Ala Gln Thr Ser Gly Pro Thr Gly Ser Pro Pro Cys Ile Gln Thr Ser
             260                 265                 270        
 Pro Asp Pro Arg Leu Ser Pro Ser Phe Arg Ala Arg Pro Glu Ala Leu
         275                 280                 285            
 His Ser Ser Pro Glu Asp Pro Val Leu Pro Arg Pro Pro Gln Thr Leu
     290                 295                 300                
 Pro Leu Asp Val Gly Gln Gly Pro Ser Glu Pro Gly Thr His Ser Pro
 305                 310                 315                 320
 Gly Leu Leu Ser Pro Thr Phe Arg Pro Gly Ala Pro Ser Gly Gln Thr
                 325                 330                 335    
 Val Pro Pro Pro Leu Pro Lys Pro Pro Arg Ser Pro Ser Arg Ser Pro
             340                 345                 350        
 Ser His Ser Pro Asn Arg Ser Pro Cys Val Pro Pro Ala Pro Asp Met
         355                 360                 365            
 Ala Leu Pro Arg Leu Gly Thr Gln Ser Thr Gly Pro Gly Arg Cys Leu
     370                 375                 380                
 Ser Pro Asn Leu Gln Ala Gln Glu Ala Pro Ala Pro Val Thr Thr Ser
 385                 390                 395                 400
 Ser Ser Thr Ser Thr Leu Ser Ser Ser Pro Trp Ser Ala Gln Pro Thr
                 405                 410                 415    
 Trp Lys Ser Asp Pro Gly Phe Arg Ile Thr Val Val Thr Trp Asn Val
             420                 425                 430        
 Gly Thr Ala Met Pro Pro Asp Asp Val Thr Ser Leu Leu His Leu Gly
         435                 440                 445            
 Gly Gly Asp Asp Ser Asp Gly Ala Asp Met Ile Ala Ile Gly Leu Gln
     450                 455                 460                
 Glu Val Asn Ser Met Leu Asn Lys Arg Leu Lys Asp Ala Leu Phe Thr
 465                 470                 475                 480
 Asp Gln Trp Ser Glu Leu Phe Met Asn Ala Leu Gly Pro Phe Asn Phe
                 485                 490                 495    
 Val Leu Val Thr His Pro Ser Pro Pro Gly Gln Pro Glu Thr Leu Leu
             500                 505                 510        
 Asn Ser Trp Leu Gln Leu Tyr Pro Gly Ser Leu Trp Gly Pro Leu Gly
         515                 520                 525            
 Leu Cys Gly Trp Val Ser Ser Val Arg Met Gln Gly Val Ile Leu Leu
     530                 535                 540                
 Leu Phe Ala Lys Tyr Tyr His Leu Pro Phe Leu Arg Asp Val Gln Thr
 545                 550                 555                 560
 Asp Cys Thr Arg Thr Gly Leu Gly Gly Tyr Trp Gly Asn Lys Gly Gly
                 565                 570                 575    
 Val Ser Val Arg Leu Ala Ala Phe Gly His Met Leu Cys Phe Leu Asn
             580                 585                 590        
 Cys His Leu Pro Ala His Met Asp Lys Ala Glu Gln Arg Lys Asp Asn
         595                 600                 605            
 Phe Gln Thr Ile Leu Ser Leu Gln Gln Phe Gln Gly Pro Gly Ala Gln
     610                 615                 620                
 Gly Ile Leu Asp His Glu Tyr Gly Leu Gly Leu Val Phe Trp Phe Gly
 625                 630                 635                 640
 Asp Leu Asn Phe Arg Ile Glu Ser Tyr Asp Leu His Phe Val Lys Phe
                 645                 650                 655    
 Ala Ile Asp Ser Asp Gln Leu His Gln Leu Trp Glu Lys Asp Gln Leu
             660                 665                 670        
 Asn Met Ala Lys Asn Thr Trp Pro Ile Leu Lys Gly Phe Gln Glu Gly
         675                 680                 685            
 Pro Leu Asn Phe Ala Pro Thr Phe Lys Phe Asp Val Gly Thr Asn Lys
     690                 695                 700                
 Tyr Asp Thr Ser Ala Lys Lys Arg Lys Pro Ala Trp Thr Asp Arg Ile
 705                 710                 715                 720
 Leu Trp Lys Val Lys Ala Pro Gly Gly Gly Pro Ser Pro Ser Gly Arg
                 725                 730                 735    
 Lys Ser His Arg Leu Gln Val Thr Gln His Ser Tyr Arg Ser His Met
             740                 745                 750        
 Glu Tyr Thr Val Ser Asp His Lys Pro Val Ala Ala Gln Phe Leu Leu
         755                 760                 765            
 Gln Phe Ala Phe Arg Asp Asp Met Pro Leu Val Arg Leu Glu Val Ala
     770                 775                 780                
 Asp Glu Trp Val Arg Pro Glu Gln Ala Val Val Arg Tyr Arg Met Glu
 785                 790                 795                 800
 Thr Val Phe Ala Arg Ser Ser Trp Asp Trp Ile Gly Leu Tyr Arg Val
                 805                 810                 815    
 Gly Phe Arg His Cys Lys Asp Tyr Val Ala Tyr Val Trp Ala Lys His
             820                 825                 830        
 Glu Asp Val Asp Gly Asn Thr Tyr Gln Val Thr Phe Ser Glu Glu Ser
         835                 840                 845            
 Leu Pro Lys Gly His Gly Asp Phe Ile Leu Gly Tyr Tyr Ser His Asn
     850                 855                 860                
 His Ser Ile Leu Ile Gly Ile Thr Glu Pro Phe Gln Ile Ser Leu Pro
 865                 870                 875                 880
 Ser Ser Glu Leu Ala Ser Ser Ser Thr Asp Ser Ser Gly Thr Ser Ser
                 885                 890                 895    
 Glu Gly Glu Asp Asp Ser Thr Leu Glu Leu Leu Ala Pro Lys Ser Arg
             900                 905                 910        
 Ser Pro Ser Pro Gly Lys Ser Lys Arg His Arg Ser Arg Ser Pro Gly
         915                 920                 925            
 Leu Ala Arg Phe Pro Gly Leu Ala Leu Arg Pro Ser Ser Arg Glu Arg
     930                 935                 940                
 Arg Gly Ala Ser Arg Ser Pro Ser Pro Gln Ser Arg Arg Leu Ser Arg
 945                 950                 955                 960
 Val Ala Pro Asp Arg Ser Ser Asn Gly Ser Ser Arg Gly Ser Ser Glu
                 965                 970                 975    
 Glu Gly Pro Ser Gly Leu Pro Gly Pro Trp Ala Phe Pro Pro Ala Val
             980                 985                 990        
 Pro Arg Ser Leu Gly Leu Leu Pro Ala Leu Arg Leu Glu Thr Val Asp
         995                1000                1005            
 Pro Gly Gly Gly Gly Ser Trp Gly Pro Asp Arg Glu Ala Leu Ala Pro
    1010                1015                1020                
 Asn Ser Leu Ser Pro Ser Pro Gln Gly His Arg Gly Leu Glu Glu Gly
1025                1030                1035                1040
 Gly Leu Gly Pro
                



      <210> 774
      <211> 164
      <212> PRT
      <213> Homo sapiens


      <400> 774
 Met Asp Pro Gly Asn Pro Gly Ser Ser Pro Arg Cys Ala Ser Arg Pro
   1               5                  10                  15    
 Leu Gly Leu Pro Arg Ser Arg Gln Lys Ala His Glu Arg Lys Val Arg
              20                  25                  30        
 His Leu Gly Gln Arg Lys Lys Lys Lys Pro Arg Cys Ile Glu Ala Gly
          35                  40                  45            
 Pro Gly Ser Ser Thr Asp Glu Gly Ala Phe Pro Ser Ala Pro Ala Leu
      50                  55                  60                
 Gly Leu Gly Glu Pro Gly Val Pro Gly Trp Lys Pro Gly Cys Thr Ser
  65                  70                  75                  80
 Asp Pro Leu Gly Val Pro Gln Gly Glu Gln Lys Ala His Glu Gly Lys
                  85                  90                  95    
 Val Arg His Leu Arg Gln Arg Lys Lys Lys Asn Arg Ala Val Glu Lys
             100                 105                 110        
 Arg Gly Leu Gly Pro Pro Leu Thr Lys Val Ser Phe Arg Gln Pro Leu
         115                 120                 125            
 Ser Trp Val Pro Arg Thr Leu Thr Ser Leu Val Arg Ala His Ala Val
     130                 135                 140                
 Pro Gln Ala Ala Thr Ser Thr Pro Arg Arg Lys Glu Gly Pro Lys Val
 145                 150                 155                 160
 Ser Ala Glu Val
                



      <210> 775
      <211> 391
      <212> PRT
      <213> Homo sapiens


      <400> 775
 Met Asn Thr Asn Pro Ser Arg Gly Pro Tyr His Phe Arg Ala Pro Ser
   1               5                  10                  15    
 Arg Ile Phe Trp Arg Thr Val Arg Gly Met Leu Pro His Lys Thr Lys
              20                  25                  30        
 Arg Gly Gln Ala Ala Leu Asp Arg Leu Lys Val Phe Asp Gly Ile Pro
          35                  40                  45            
 Pro Pro Tyr Asp Lys Lys Lys Arg Met Val Val Pro Ala Ala Leu Lys
      50                  55                  60                
 Val Val Arg Leu Lys Pro Thr Arg Lys Phe Ala Tyr Leu Gly Arg Leu
  65                  70                  75                  80
 Ala His Glu Val Gly Trp Lys Tyr Gln Ala Val Thr Ala Thr Leu Glu
                  85                  90                  95    
 Glu Pro Arg Ser Arg Leu Thr Ala Leu Pro Pro Pro Pro Ser Phe Leu
             100                 105                 110        
 Gln Thr Pro Lys Ser Arg Ala Leu Met Ala Gly Leu Glu Val Leu Phe
         115                 120                 125            
 Ala Ser Ala Ala Pro Ala Ile Thr Cys Arg Gln Asp Ala Leu Val Cys
     130                 135                 140                
 Phe Leu His Trp Glu Val Val Thr His Gly Tyr Phe Gly Leu Gly Val
 145                 150                 155                 160
 Gly Asp Gln Pro Gly Pro Asn Asp Lys Lys Ser Glu Leu Leu Pro Ala
                 165                 170                 175    
 Gly Trp Asn Asn Asn Lys Asp Leu Tyr Val Leu Arg Tyr Glu Tyr Lys
             180                 185                 190        
 Asp Gly Ser Arg Lys Leu Leu Val Lys Ala Ile Thr Val Glu Ser Ser
         195                 200                 205            
 Met Ile Leu Asn Val Leu Glu Tyr Gly Ser Gln Gln Val Ala Asp Leu
     210                 215                 220                
 Thr Leu Asn Leu Asp Asp Tyr Ile Asp Ala Glu His Leu Gly Asp Phe
 225                 230                 235                 240
 His Arg Thr Tyr Lys Asn Ser Glu Glu Leu Arg Ser Arg Ile Val Ser
                 245                 250                 255    
 Gly Ile Ile Thr Pro Ile His Glu Gln Trp Glu Lys Ala Asn Val Ser
             260                 265                 270        
 Ser Pro His Arg Glu Phe Pro Pro Ala Thr Ala Arg Glu Val Asp Pro
         275                 280                 285            
 Leu Arg Ile Pro Pro Arg His Pro His Thr Ser Arg Gln Pro Pro Trp
     290                 295                 300                
 Cys Asp Pro Leu Gly Pro Phe Val Val Gly Gly Glu Asp Leu Asp Pro
 305                 310                 315                 320
 Phe Gly Pro Arg Arg Gly Gly Met Ile Val Asp Pro Leu Arg Ser Gly
                 325                 330                 335    
 Phe Pro Arg Ala Leu Ile Asp Pro Ser Ser Gly Leu Pro Asn Arg Leu
             340                 345                 350        
 Pro Pro Gly Ala Val Pro Pro Gly Ala Arg Phe Asp Pro Phe Gly Pro
         355                 360                 365            
 Ile Gly Thr Ser Pro Pro Gly Pro Asn Pro Asp His Leu Pro Pro Pro
     370                 375                 380                
 Gly Tyr Asp Asp Met Tyr Leu
 385                 390    



      <210> 776
      <211> 167
      <212> PRT
      <213> Homo sapiens


      <400> 776
 Met Glu Glu Thr Tyr Thr Asp Ser Leu Asp Pro Glu Lys Leu Leu Gln
   1               5                  10                  15    
 Cys Pro Tyr Asp Lys Asn His Gln Ile Arg Ala Cys Arg Phe Pro Tyr
              20                  25                  30        
 His Leu Ile Lys Cys Arg Lys Asn His Pro Asp Val Ala Ser Lys Leu
          35                  40                  45            
 Ala Thr Cys Pro Phe Asn Ala Arg His Gln Val Pro Arg Ala Glu Ile
      50                  55                  60                
 Ser His His Ile Ser Ser Cys Asp Asp Arg Ser Cys Ile Glu Gln Asp
  65                  70                  75                  80
 Val Val Asn Gln Thr Arg Ser Leu Arg Gln Glu Thr Leu Ala Glu Ser
                  85                  90                  95    
 Thr Trp Gln Cys Pro Pro Cys Asp Glu Asp Trp Asp Lys Asp Leu Trp
             100                 105                 110        
 Glu Gln Thr Ser Thr Pro Phe Val Trp Gly Thr Thr His Tyr Ser Asp
         115                 120                 125            
 Asn Asn Ser Pro Ala Ser Asn Ile Val Thr Glu His Lys Asn Asn Leu
     130                 135                 140                
 Ala Ser Gly Met Arg Val Pro Lys Ser Leu Pro Tyr Val Leu Pro Trp
 145                 150                 155                 160
 Lys Asn Asn Gly Asn Ala Gln
                 165        



      <210> 777
      <211> 263
      <212> PRT
      <213> Homo sapiens


      <400> 777
 Met Asp Lys Asp Ala Lys Lys Arg Ile His Asn Phe Ser Val Ile Asn
   1               5                  10                  15    
 Pro Val Pro Gly Gln Ala Ile Thr Gln Ile Phe Ala Val Asp Asn Arg
              20                  25                  30        
 Glu Asp Leu Gln Lys Trp Met Glu Ala Phe Trp Gln His Phe Phe Asp
          35                  40                  45            
 Leu Ser Gln Trp Lys His Cys Cys Glu Glu Leu Met Lys Ile Glu Ile
      50                  55                  60                
 Met Ser Pro Arg Lys Pro Pro Leu Phe Leu Thr Lys Glu Ala Thr Ser
  65                  70                  75                  80
 Val Tyr His Asp Met Ser Ile Asp Ser Pro Met Lys Leu Glu Ser Leu
                  85                  90                  95    
 Thr Asp Ile Ile Gln Lys Lys Ile Glu Glu Thr Asn Gly Gln Phe Leu
             100                 105                 110        
 Ile Gly Gln Arg Glu Glu Ser Leu Pro Pro Pro Trp Ala Thr Leu Phe
         115                 120                 125            
 Asp Gly Asn His Gln Met Val Ile Gln Lys Lys Val Leu Tyr Pro Ala
     130                 135                 140                
 Ser Glu Pro Leu His Asp Glu Lys Gly Lys Lys Arg Gln Ala Pro Leu
 145                 150                 155                 160
 Pro Pro Ser Asp Lys Leu Pro Phe Ser Leu Lys Ser Gln Ser Asn Thr
                 165                 170                 175    
 Asp Gln Leu Val Lys Asp Asn Trp Gly Lys Thr Ser Val Ser Gln Thr
             180                 185                 190        
 Ser Ser Leu Asp Thr Lys Leu Ser Thr Leu Met His His Leu Gln Lys
         195                 200                 205            
 Pro Met Ala Ala Pro Arg Lys Leu Leu Pro Ala Arg Arg Asn Arg Leu
     210                 215                 220                
 Ser Asp Gly Glu His Thr Asp Thr Lys Thr Asn Phe Glu Ala Lys Pro
 225                 230                 235                 240
 Val Pro Ala Pro Arg Gln Lys Ser Ile Lys Asp Ile Leu Asp Pro Arg
                 245                 250                 255    
 Ser Trp Leu Gln Ala Gln Val
             260            



      <210> 778
      <211> 97
      <212> PRT
      <213> Homo sapiens


      <400> 778
 Met Ala Leu Asp Ser Asp Leu Trp Ser Arg Leu Glu Glu Lys Ala Arg
   1               5                  10                  15    
 Ala Lys Cys Glu Arg Asp Glu Ala Gly Asn Pro Ala Lys Glu Ser Ser
              20                  25                  30        
 Asp Ala Asp Gly Glu Ala Glu Glu Glu Gly Glu Ser Glu Lys Gly Ala
          35                  40                  45            
 Gly Pro Arg Ser Ala Gly Trp Arg Ala Leu Arg Arg Leu Trp Asp Arg
      50                  55                  60                
 Val Leu Gly Pro Ala Arg Arg Trp Arg Arg Pro Leu Pro Ser Asn Val
  65                  70                  75                  80
 Leu Tyr Cys Ala Glu Ile Lys Asp Ile Gly His Leu Thr Arg Cys Thr
                  85                  90                  95    
 Leu
    



      <210> 779
      <211> 63
      <212> PRT
      <213> Homo sapiens


      <400> 779
 Met Cys Gly Glu Phe Arg Arg Asp Arg Glu Thr Ser Ser Arg Gly Met
   1               5                  10                  15    
 Asn Glu Glu Glu Glu Lys Glu Glu Glu Lys Lys Glu Lys Glu Glu Met
              20                  25                  30        
 Glu Met Glu Ile Met Glu Met Glu Glu Glu Lys Glu Glu Arg Glu Glu
          35                  40                  45            
 Glu Glu Glu Glu Thr Gln Lys Glu Lys Met Glu Glu Glu Glu Lys
      50                  55                  60            



      <210> 780
      <211> 286
      <212> PRT
      <213> Homo sapiens


      <400> 780
 Met Arg His Asn Gln Met Cys Cys Glu Thr Pro Pro Thr Val Thr Val
   1               5                  10                  15    
 Tyr Val Lys Ser Gly Ser Asn Arg Ser His Gln Pro Lys Lys Pro Ile
              20                  25                  30        
 Thr Leu Lys Arg Pro Ile Cys Lys Asp Asn Trp Gln Ala Phe Glu Lys
          35                  40                  45            
 Asn Thr His Asn Asn Asn Lys Ser Lys Arg Pro Lys Gly Pro Cys Leu
      50                  55                  60                
 Val Ile Gln Arg Gln Asp Met Thr Ala Phe Phe Lys Leu Phe Asp Asp
  65                  70                  75                  80
 Asp Leu Ile Gln Asp Phe Leu Trp Met Asp Cys Cys Cys Lys Ile Ala
                  85                  90                  95    
 Asp Lys Tyr Leu Leu Ala Met Thr Phe Val Tyr Phe Lys Arg Ala Lys
             100                 105                 110        
 Phe Thr Ile Ser Glu His Thr Arg Ile Asn Phe Phe Ile Ala Leu Tyr
         115                 120                 125            
 Leu Ala Asn Thr Val Glu Glu Asp Glu Glu Glu Thr Lys Tyr Glu Ile
     130                 135                 140                
 Phe Pro Trp Ala Leu Gly Lys Asn Trp Arg Lys Leu Phe Pro Asn Phe
 145                 150                 155                 160
 Leu Lys Leu Arg Asp Gln Leu Trp Asp Arg Ile Asp Tyr Arg Ala Ile
                 165                 170                 175    
 Val Ser Arg Arg Cys Cys Glu Glu Val Met Ala Ile Ala Pro Thr His
             180                 185                 190        
 Tyr Ile Trp Gln Arg Glu Arg Ser Val His His Ser Gly Ala Val Arg
         195                 200                 205            
 Asn Tyr Asn Arg Asp Glu Val Gln Leu Pro Arg Gly Pro Ser Ala Thr
     210                 215                 220                
 Pro Val Asp Cys Ser Leu Cys Gly Lys Lys Arg Arg Tyr Val Arg Leu
 225                 230                 235                 240
 Gly Leu Ser Ser Ser Ser Ser Leu Ser Ser His Thr Ala Gly Val Thr
                 245                 250                 255    
 Glu Lys His Ser Gln Asp Ser Tyr Asn Ser Leu Ser Met Asp Ile Ile
             260                 265                 270        
 Gly Asp Pro Ser Gln Ala Tyr Thr Gly Ser Glu Gly Met Ile
         275                 280                 285    



      <210> 781
      <211> 471
      <212> PRT
      <213> Homo sapiens


      <400> 781
 Met Asp Ser Ser Cys His Asn Ala Thr Thr Lys Met Leu Ala Thr Ala
   1               5                  10                  15    
 Pro Ala Arg Gly Asn Met Met Ser Thr Ser Lys Pro Leu Ala Phe Ser
              20                  25                  30        
 Ile Glu Arg Ile Met Ala Arg Thr Pro Glu Pro Lys Ala Leu Pro Val
          35                  40                  45            
 Pro His Phe Leu Gln Gly Ala Leu Pro Lys Gly Glu Pro Lys His Ser
      50                  55                  60                
 Leu His Leu Asn Ser Ser Ile Pro Cys Met Ile Pro Phe Val Pro Val
  65                  70                  75                  80
 Ala Tyr Asp Thr Ser Pro Lys Ala Gly Val Thr Gly Ser Glu Pro Arg
                  85                  90                  95    
 Lys Ala Ser Leu Glu Ala Pro Ala Ala Pro Ala Ala Val Pro Ser Ala
             100                 105                 110        
 Pro Ala Phe Ser Cys Ser Asp Leu Leu Asn Cys Ala Leu Ser Leu Lys
         115                 120                 125            
 Gly Asp Leu Ala Arg Asp Ala Leu Pro Leu Gln Gln Tyr Lys Leu Val
     130                 135                 140                
 Arg Pro Arg Val Val Asn His Ser Ser Phe His Ala Met Gly Ala Leu
 145                 150                 155                 160
 Cys Tyr Leu Asn Arg Gly Asp Gly Pro Cys His Pro Ala Ala Gly Val
                 165                 170                 175    
 Asn Ile His Pro Val Ala Ser Tyr Phe Leu Ser Ser Pro Leu His Pro
             180                 185                 190        
 Gln Pro Lys Thr Tyr Leu Ala Glu Arg Asn Lys Leu Val Val Pro Ala
         195                 200                 205            
 Val Glu Lys Tyr Pro Ser Gly Val Ala Phe Lys Asp Leu Ser Gln Ala
     210                 215                 220                
 Gln Leu Gln His Tyr Met Lys Glu Ser Ala Gln Leu Leu Ser Glu Lys
 225                 230                 235                 240
 Ile Ala Phe Lys Thr Ser Asp Phe Ser Arg Gly Ser Pro Asn Ala Lys
                 245                 250                 255    
 Pro Lys Val Phe Thr Cys Glu Val Phe Asn Ala His Tyr Asn Leu Thr
             260                 265                 270        
 Arg His Met Pro Val His Thr Gly Ala Arg Pro Phe Val Cys Lys Val
         275                 280                 285            
 Cys Gly Lys Gly Phe Arg Gln Ala Ser Thr Leu Cys Arg His Lys Ile
     290                 295                 300                
 Ile His Thr Gln Glu Lys Pro His Lys Cys Asn Gln Cys Gly Lys Ala
 305                 310                 315                 320
 Phe Asn Arg Ser Ser Thr Leu Asn Thr His Thr Arg Ile His Ala Gly
                 325                 330                 335    
 Tyr Lys Pro Phe Val Cys Glu Phe Cys Gly Lys Gly Phe His Gln Lys
             340                 345                 350        
 Gly Asn Tyr Lys Asn His Lys Leu Thr His Ser Gly Glu Lys Gln Phe
         355                 360                 365            
 Lys Cys Asn Ile Cys Asn Lys Ala Phe His Gln Val Tyr Asn Leu Thr
     370                 375                 380                
 Phe His Met His Thr His Asn Asp Lys Lys Pro Phe Thr Cys Pro Thr
 385                 390                 395                 400
 Cys Gly Lys Gly Phe Cys Arg Asn Phe Asp Leu Lys Lys His Val Arg
                 405                 410                 415    
 Lys Leu His Asp Ser Ser Leu Gly Leu Ala Arg Thr Pro Ala Gly Glu
             420                 425                 430        
 Pro Gly Thr Glu Pro Pro Pro Pro Leu Pro Gln Gln Pro Pro Met Thr
         435                 440                 445            
 Leu Pro Pro Leu Gln Pro Pro Leu Pro Thr Pro Gly Pro Leu Gln Pro
     450                 455                 460                
 Gly Leu His Gln Gly His Gln
 465                 470    



      <210> 782
      <211> 471
      <212> PRT
      <213> Homo sapiens


      <400> 782
 Met Val Leu Asp Ser Gly Ala Gln Ala Tyr Asp Gln Ala Pro Pro Ser
   1               5                  10                  15    
 Pro Pro Thr Ser Pro Pro Ser Leu Arg His Arg Leu Lys Pro Ser Asp
              20                  25                  30        
 Arg Asp Gly Pro Pro Leu Tyr Pro Trp Ser Gln Ser Leu Ala Leu Pro
          35                  40                  45            
 Leu Ala Leu Ala Val Pro Pro Ala Leu Gln Pro Gln Pro Glu Gln Gln
      50                  55                  60                
 Pro Phe Ser Gln Met Leu Leu Gly His Arg Gly His Met Arg Arg Ser
  65                  70                  75                  80
 Glu Ser Thr Tyr Ser Val Asn Ser Thr Gly Arg Arg Gly Arg Gly Thr
                  85                  90                  95    
 Leu Gly Arg Pro Pro Pro Gly Arg Gly Arg Asn Pro Gly Gly Gly Thr
             100                 105                 110        
 Leu Arg Pro Ala Ala Ser Leu Pro His Ile Ala Lys Thr Gln Arg Asp
         115                 120                 125            
 Ala Gly His Ile Ala Ser Lys Ser Pro Cys Met Leu Val Ala Leu Arg
     130                 135                 140                
 Pro Thr Asn Met Asp Arg Glu Arg Asp Lys Phe Phe Gln Ser His Tyr
 145                 150                 155                 160
 Thr Tyr Asn Pro Gln Phe Glu Tyr Gln Glu Pro Met Pro Thr Ala Val
                 165                 170                 175    
 Leu Glu Lys Tyr Cys Glu Ala Ser Gly Gln Phe Ile His Gln Ala Val
             180                 185                 190        
 Gly Ile Ile Glu Ala Val Leu Glu Lys Phe Gly Thr Tyr Glu His Phe
         195                 200                 205            
 Glu Ala Ala Thr Gly Gly Gln Leu Leu Thr Lys Cys Gln Ile Trp Ser
     210                 215                 220                
 Ile Val Arg Lys Tyr Met Gln Lys Glu Gly Cys Ala Gly Glu Val Val
 225                 230                 235                 240
 Val Gln Leu Ser Glu Asp Leu Leu Ser Gln Ala Val Met Met Val Glu
                 245                 250                 255    
 Asn Ser Arg Pro Thr Leu Ala Ile Asn Leu Thr Gly Ala Arg Gln Tyr
             260                 265                 270        
 Trp Leu Glu Gly Met Leu Arg His Glu Ile Gly Thr His Tyr Leu Arg
         275                 280                 285            
 Gly Val Asn Asn Ala Arg Gln Pro Trp His Asn Ala Glu Gly Arg Leu
     290                 295                 300                
 Arg Tyr Gly Leu Arg Pro Ala Asn Pro Thr Glu Glu Gly Leu Ala Ser
 305                 310                 315                 320
 Leu His Ser Val Leu Phe Arg Lys Gln Pro Phe Leu Trp Arg Ala Ala
                 325                 330                 335    
 Leu Leu Tyr Tyr Thr Ile His Arg Ala Ala Arg Met Ser Phe Arg Gln
             340                 345                 350        
 Leu Phe Gln Asp Leu Glu Arg Tyr Val Gln Asp Ala Asp Val Arg Trp
         355                 360                 365            
 Glu Tyr Cys Val Arg Ala Lys Arg Gly Gln Thr Asp Thr Ser Leu Pro
     370                 375                 380                
 Gly Cys Phe Ser Lys Asp Gln Val Tyr Leu Asp Gly Ile Val Arg Ile
 385                 390                 395                 400
 Leu Arg His Arg Gln Thr Ile Asp Phe Pro Leu Leu Thr Ser Leu Gly
                 405                 410                 415    
 Lys Val Ser Tyr Glu Asp Val Asp His Leu Arg Pro His Gly Val Leu
             420                 425                 430        
 Asp Asn Thr Arg Val Pro His Phe Met Gln Asp Leu Ala Arg Tyr Arg
         435                 440                 445            
 Gln Gln Leu Glu His Ile Met Ala Thr Asn Arg Leu Asp Glu Ala Glu
     450                 455                 460                
 Leu Gly Arg Leu Leu Pro Asp
 465                 470    



      <210> 783
      <211> 83
      <212> PRT
      <213> Homo sapiens


      <400> 783
 Met Glu Ala Leu Gly Ser Gly His Tyr Val Gly Gly Ser Ile Arg Ser
   1               5                  10                  15    
 Met Ala Ala Ala Ala Leu Ser Gly Leu Ala Val Arg Leu Ser Arg Pro
              20                  25                  30        
 Gln Gly Thr Arg Gly Ser Tyr Gly Ala Phe Cys Lys Thr Leu Thr Arg
          35                  40                  45            
 Thr Leu Leu Thr Phe Phe Asp Leu Ala Trp Arg Leu Arg Lys Asn Phe
      50                  55                  60                
 Phe Tyr Phe Tyr Ile Leu Ala Ser Val Ile Leu Asn Val His Leu Gln
  65                  70                  75                  80
 Val Tyr Ile
            



      <210> 784
      <211> 93
      <212> PRT
      <213> Homo sapiens


      <400> 784
 Met Gly Leu Glu Gly Ser Val Val Ser Ser Gly Leu Arg Asp Cys Lys
   1               5                  10                  15    
 Arg Ala Ser Leu Lys Arg Ser Gly Leu Trp Ala Ala Glu Pro Pro Gly
              20                  25                  30        
 Ile Leu Thr Ala Glu Gln Glu Ala Glu Val Arg Val Gln Asp Gly Leu
          35                  40                  45            
 Lys Met Ser Gln Gln Leu Gly Ala Gln Pro Arg Pro Asn Leu Val Glu
      50                  55                  60                
 Arg Arg Asn Ile Arg Cys Ser Arg Arg Asn Leu Ile Ile Tyr Glu Arg
  65                  70                  75                  80
 Gly Gln Leu Thr Gly Leu His Phe Ser Lys Pro Ile Leu
                  85                  90            



      <210> 785
      <211> 219
      <212> PRT
      <213> Homo sapiens


      <400> 785
 Met Ala Asn Trp Val Phe Cys Asn Arg Cys Phe Gln Pro Pro His Arg
   1               5                  10                  15    
 Thr Ser Cys Phe Ser Leu Thr Asn Cys Gly His Val Tyr Cys Asp Ala
              20                  25                  30        
 Cys Leu Gly Lys Gly Lys Lys Asn Glu Cys Leu Ile Cys Lys Ala Pro
          35                  40                  45            
 Cys Arg Thr Val Leu Leu Ser Lys His Thr Asp Ala Asp Ile Gln Ala
      50                  55                  60                
 Phe Phe Met Ser Ile Asp Ser Leu Cys Lys Lys Tyr Ser Arg Glu Thr
  65                  70                  75                  80
 Ser Gln Ile Leu Glu Phe Gln Glu Lys His Arg Lys Arg Leu Leu Ala
                  85                  90                  95    
 Phe Tyr Arg Glu Lys Ile Ser Arg Leu Glu Glu Ser Leu Arg Lys Ser
             100                 105                 110        
 Val Leu Gln Ile Glu Gln Leu Gln Ser Met Arg Ser Ser Gln Gln Thr
         115                 120                 125            
 Ala Phe Ser Thr Ile Lys Ser Ser Val Ser Thr Lys Pro His Gly Cys
     130                 135                 140                
 Leu Leu Pro Pro His Ser Ser Ala Pro Asp Arg Leu Glu Ser Met Glu
 145                 150                 155                 160
 Val Asp Leu Ser Pro Ser Pro Ile Arg Lys Ser Glu Ile Ala Ala Gly
                 165                 170                 175    
 Pro Ala Arg Ile Ser Met Ile Ser Pro Pro Gln Asp Gly Arg Met Gly
             180                 185                 190        
 Ser Val Ser Ser Leu Gly Pro Glu His Pro Gly Leu Thr Thr Ser Gln
         195                 200                 205            
 Arg Ser Met Gly Lys Pro Leu Ser Val Lys Phe
     210                 215                



      <210> 786
      <211> 204
      <212> PRT
      <213> Homo sapiens


      <400> 786
 Met Val Asp Tyr Tyr Glu Val Leu Asp Val Pro Arg Gln Ala Ser Ser
   1               5                  10                  15    
 Glu Ala Ile Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys Trp His Pro
              20                  25                  30        
 Asp Lys Asn Pro Glu Asn Lys Glu Glu Ala Glu Arg Arg Phe Lys Gln
          35                  40                  45            
 Val Ala Glu Ala Tyr Glu Val Leu Ser Asp Ala Lys Lys Arg Asp Ile
      50                  55                  60                
 Tyr Asp Arg Tyr Gly Glu Ala Gly Ala Glu Gly Gly Cys Thr Gly Gly
  65                  70                  75                  80
 Arg Pro Phe Glu Asp Pro Phe Glu Tyr Val Phe Ser Phe Arg Asp Pro
                  85                  90                  95    
 Ala Asp Val Phe Arg Glu Phe Phe Gly Gly Gln Asp Pro Phe Ser Phe
             100                 105                 110        
 Asp Leu Leu Gly Asn Pro Leu Glu Asn Ile Leu Gly Gly Glu Phe Pro
         115                 120                 125            
 Ala Phe Gly Gly Val Phe Ser Ser Phe Asp Thr Gly Phe Arg Ser Phe
     130                 135                 140                
 Gly Ser Leu Gly Ser Gly Gly Leu Ser Ser Phe Cys Met Ser Tyr Gly
 145                 150                 155                 160
 Ser Asp Gly Thr Gly Ser Phe Lys Ser Met Ser Thr Ser Thr Glu Ile
                 165                 170                 175    
 Val Asp Gly Lys Lys Ile Thr Thr Lys Arg Ile Ile Glu Asn Gly Gln
             180                 185                 190        
 Glu Arg Val Glu Val Glu Glu Asp Gly Glu Leu Ser
         195                 200                



      <210> 787
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 787
 Met Asn Asp Thr Val Thr Ile Arg Thr Arg Lys Phe Met Thr Asn Arg
   1               5                  10                  15    
 Leu Leu Gln Arg Lys Gln Met Val Ile Asp Val Leu His Pro Gly Lys
              20                  25                  30        
 Ala Thr Val Pro Lys Thr Glu Ile Arg Glu Lys Leu Ala Lys Met Tyr
          35                  40                  45            
 Lys Thr Thr Pro Asp Val Ile Phe Val Phe Gly Phe Arg Thr His Phe
      50                  55                  60                
 Gly Gly Gly Lys Thr Thr Gly Phe Gly Met Ile Tyr Asp Ser Leu Asp
  65                  70                  75                  80
 Tyr Ala Lys Lys Asn Glu Pro Lys His Arg Leu Ala Arg His Gly Leu
                  85                  90                  95    
 Tyr Glu Lys Lys Lys Thr Ser Arg Lys Gln Arg Lys Glu Arg Lys Asn
             100                 105                 110        
 Arg Met Lys Lys Val Arg Gly Thr Ala Lys Ala Asn Val Gly Ala Gly
         115                 120                 125            
 Lys Lys Lys Trp Ala Gly Asp Trp Ile Thr Ala Glu Gly Val Lys Val
     130                 135                 140                
 Leu Gln
 145    



      <210> 788
      <211> 524
      <212> PRT
      <213> Homo sapiens


      <400> 788
 Met Lys Glu Pro Arg Ile Phe Pro Arg Glu Arg Pro Thr Pro Trp Thr
   1               5                  10                  15    
 Arg Ala Pro Leu Pro Pro Arg Gly Arg Leu Asp Gly Ser Leu Gly Pro
              20                  25                  30        
 Gln Gly Gly Pro Val Leu Asn Thr Gly His Pro Leu Gly Val Asn Ser
          35                  40                  45            
 Asp Pro Phe Leu Met Ala Ala Gly Ser Leu Gly Gly Asn Leu Thr Pro
      50                  55                  60                
 Phe Pro Arg Asn Pro Ser Pro Phe Pro Ala Ser Ser Gly Ser Leu Ala
  65                  70                  75                  80
 Ser Asn Pro Ala Pro Phe Pro Ala Gly Ala Arg Asp Pro Ser Met Ala
                  85                  90                  95    
 Ser Phe Pro Arg Gly Met Asn Pro Thr Gly Thr Gly Ala Val Ser Phe
             100                 105                 110        
 Pro Arg Pro Gly Gly Leu Leu Gly Pro Gly Pro Gly Pro Gly Pro Thr
         115                 120                 125            
 Leu Asn Pro Arg Thr Gly Ala Leu Pro Gly Pro Gly Pro Leu Ser Asn
     130                 135                 140                
 Pro Arg Leu Gly Gly Leu Pro Gly Pro Gly Pro Met Ser Asn Pro Arg
 145                 150                 155                 160
 Ala Gly Gly Leu Leu Gly Ala Gly Pro Asp Pro Arg Gly Gly Gly Pro
                 165                 170                 175    
 Met Gly Pro Gly Ser Gly Pro Asn Leu Arg Ala Gly Val Leu Leu Thr
             180                 185                 190        
 Ser Gly Asn Gly Pro Pro Asn Pro Arg Pro Val Gly Leu Gly Pro Gly
         195                 200                 205            
 Pro Asn Pro Asn Leu Arg Ser Gly Phe Leu Gly Thr Asn Pro Ala Pro
     210                 215                 220                
 Arg Ser Gly Val Phe Pro Gly Pro Gly Leu Gly Pro Asn Pro Arg Pro
 225                 230                 235                 240
 Ser Gly Leu Gly Pro Gly Pro Asn Leu Asp Ala Arg Ala Gly Gly Leu
                 245                 250                 255    
 Leu Gly Thr Gly Ser Gly Leu Asn Leu Arg Met Ala Gly Pro Gln Gly
             260                 265                 270        
 Leu Asp Leu Ala Pro Ile Leu Arg Ala Ala Gly Leu Leu Gly Ala Asn
         275                 280                 285            
 Ser Ala Ser Phe Ser Gln Ala Ser Gly Asn Met Gly Thr Ser Pro Ser
     290                 295                 300                
 Ser Met Ala Arg Val Pro Gly Pro Met Gly Pro Asn Ser Gly Pro Ser
 305                 310                 315                 320
 Ser Arg Gly Ile Gly Leu Pro Gly Pro Asn Pro Ser Pro Met Ser Arg
                 325                 330                 335    
 Ala Pro Gly Pro Ile Gly Pro Asn Ser Ala His Phe Ser Arg Pro Val
             340                 345                 350        
 Gly Pro Met Gly Val Asn Ala Asn Pro Phe Pro Arg Gly Ala Gly Ser
         355                 360                 365            
 Ser Ala Phe Ser Gln Ser Ser Gly Thr Leu Ala Ser Asn Pro Ala Thr
     370                 375                 380                
 Phe Gln Arg Ser Ala Gly Leu Gln Gly Ser Asn Pro Thr Ile Phe Pro
 385                 390                 395                 400
 Arg Ala Ser Gly Pro Leu Gly Pro Asn Pro Ala Asn Phe Pro Arg Ala
                 405                 410                 415    
 Thr Gly Leu Gln Gly Pro Ser Pro Thr Thr Phe Pro Arg Ser Thr Gly
             420                 425                 430        
 Pro Leu Gly Pro Gly Gln Val Thr Phe Pro Arg Pro Ala Ala Gly His
         435                 440                 445            
 Leu Gly Pro Ser Pro Ala Gly Pro Val Gly Ile Asn Pro Ala Pro Phe
     450                 455                 460                
 Thr Arg Pro Thr Gly Thr Leu Gly Leu Asn Pro Ala Ser Phe Pro Arg
 465                 470                 475                 480
 Met Asn Gly Pro Ala Gly Lys Ser Phe Val Pro Phe Pro Arg Val Gly
                 485                 490                 495    
 Ser Leu Pro Gly Thr Asn Pro Ala Ala Phe Pro Arg Pro Gly Gly Pro
             500                 505                 510        
 Met Ala Ala Met Tyr Pro Asn Gly Met Leu Pro Pro
         515                 520                



      <210> 789
      <211> 81
      <212> PRT
      <213> Homo sapiens


      <400> 789
 Met Leu Trp Val Thr Arg Gly Arg Glu Asp Arg Lys Arg Gly Glu Leu
   1               5                  10                  15    
 Gln Pro Phe Gly Glu Pro Lys Ser Arg Ser Ser Val Ser Gln Gly Cys
              20                  25                  30        
 Asp Thr Leu Phe Gly Ala Leu Trp Phe Leu Leu Ser Pro Ser Phe Trp
          35                  40                  45            
 Ala Pro Leu His Ser Leu Val Pro Ala Val Glu Ala Ala Cys Gly Ile
      50                  55                  60                
 Pro Gly Pro Asp Ala Ala Ser Gln Arg Ala Gly Val Ser Gly Cys Ala
  65                  70                  75                  80
 Gln
    



      <210> 790
      <211> 152
      <212> PRT
      <213> Homo sapiens


      <400> 790
 Met Ala Val Arg Ala Gly Asp Glu Ser Gln Leu Gln Asp Glu Gly Lys
   1               5                  10                  15    
 His Pro Leu Pro Cys Val Cys Gly Arg Gln Ala Ala Gln Gly Ser Arg
              20                  25                  30        
 Gly Ser Gly Glu Leu Thr Phe Cys Cys Cys Leu Gln Pro Pro Ala Arg
          35                  40                  45            
 Cys Ala Trp Arg Gly Leu Ala Gly Phe Leu Arg Ala Glu Glu Leu Leu
      50                  55                  60                
 Asn Lys Thr Val Lys Arg Lys Thr His Arg Leu Leu Arg Glu Asn Ser
  65                  70                  75                  80
 Leu Tyr Thr Cys Val Arg Ala Pro Gly Leu Ile Ala Pro Cys Trp Met
                  85                  90                  95    
 Cys Gln Lys Glu Glu Cys Lys Asp Ser Glu Ala Arg Trp Ala Val His
             100                 105                 110        
 His Leu Thr Gln Val Asn Val Val Val Val Met Arg Ala Arg Pro Gly
         115                 120                 125            
 Ala Ser Arg Ser Thr Phe Leu Gly Val Cys Arg Ser Leu Gln Glu Glu
     130                 135                 140                
 Pro Val Cys Tyr Thr Ser Ser Ile
 145                 150        



      <210> 791
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 791
 Met Arg Gly Lys Tyr Gln Ile Leu Lys Asn Leu Asn Tyr Tyr Lys Gly
   1               5                  10                  15    
 Thr Phe Ser Ala Thr Leu Lys Asn Val Arg Ile Ser Lys Glu Ile Asp
              20                  25                  30        
 Asn Phe Leu Gly Lys His Asp Leu Pro Lys Leu Thr Leu Glu Lys Asn
          35                  40                  45            
 Arg Tyr Thr Ser Val Thr Thr Glu Val Glu Lys Val Val Asn Ile Leu
      50                  55                  60                
 Pro Asn Leu Glu Phe Met Ile Glu Phe Phe Glu Ile Tyr Cys Glu Tyr
  65                  70                  75                  80
 Ile Leu Cys Leu Cys Ser Ala Val Pro Glu Leu Lys Lys Arg Asn Phe
                  85                  90                  95    
 Gln Ile Leu Phe Ser Asn Ser Glu Thr Met Leu Leu Lys Tyr Ile Gly
             100                 105                 110        
 Asn Arg Asn Glu Asn Tyr Ser Ser Val Ser Leu Ile Ile Ser Ile Leu
         115                 120                 125            
 Lys Leu Gly Ile Lys Asn Thr Ser Ile
     130                 135        



      <210> 792
      <211> 1344
      <212> PRT
      <213> Homo sapiens


      <400> 792
 Met Ser Arg Gly Lys Val Ile Arg Leu His Arg Arg Lys Gln Asp Asn
   1               5                  10                  15    
 Ile Ser Gly Gly Asp Ser Ser Ala Thr Glu Ser Trp Asp Glu Glu Leu
              20                  25                  30        
 Ser Pro Ser Thr Val Leu Tyr Thr Ala Thr Gln His Thr Pro Thr Ser
          35                  40                  45            
 Ile Thr Leu Thr Val Arg Arg Thr Lys Pro Lys Lys Arg Lys Lys Ser
      50                  55                  60                
 Pro Glu Lys Gly Arg Ala Ala Pro Lys Thr Lys Lys Ile Lys Ala Phe
  65                  70                  75                  80
 Arg Glu Gly Ser Arg Lys Ser Leu Arg Met Lys Asn Ser Pro Ser Glu
                  85                  90                  95    
 Ala Gln Asn Leu Asp Glu Asn Thr Thr Glu Gly Trp Glu Asn Arg Ile
             100                 105                 110        
 Arg Leu Trp Thr Asp Gln Tyr Glu Glu Ala Phe Thr Asn Gln Tyr Ser
         115                 120                 125            
 Ala Asp Val Gln Asn Ala Leu Glu Gln His Leu His Ser Ser Lys Glu
     130                 135                 140                
 Phe Val Gly Lys Pro Thr Ile Leu Asp Thr Ile Asn Lys Thr Glu Leu
 145                 150                 155                 160
 Ala Cys Asn Asn Thr Val Ile Gly Ser Gln Met Gln Leu Gln Leu Gly
                 165                 170                 175    
 Arg Val Thr Arg Val Gln Lys His Arg Lys Ile Leu Arg Ala Ala Arg
             180                 185                 190        
 Asp Leu Ala Leu Asp Thr Leu Ile Ile Glu Tyr Arg Gly Lys Val Met
         195                 200                 205            
 Leu Arg Gln Gln Phe Glu Val Asn Gly His Phe Phe Lys Lys Pro Tyr
     210                 215                 220                
 Pro Phe Val Leu Phe Tyr Ser Lys Phe Asn Gly Val Glu Met Cys Val
 225                 230                 235                 240
 Asp Ala Arg Thr Phe Gly Asn Asp Ala Arg Phe Ile Arg Arg Ser Cys
                 245                 250                 255    
 Thr Pro Asn Ala Glu Val Arg His Met Ile Ala Asp Gly Met Ile His
             260                 265                 270        
 Leu Cys Ile Tyr Ala Val Ser Ala Ile Thr Lys Asp Ala Glu Val Thr
         275                 280                 285            
 Ile Ala Phe Asp Tyr Glu Tyr Ser Asn Cys Asn Tyr Lys Val Asp Cys
     290                 295                 300                
 Ala Cys His Lys Gly Asn Arg Asn Cys Pro Ile Gln Lys Arg Asn Pro
 305                 310                 315                 320
 Asn Ala Thr Glu Leu Pro Leu Leu Pro Pro Pro Pro Ser Leu Pro Thr
                 325                 330                 335    
 Ile Gly Ala Glu Thr Arg Arg Arg Lys Ala Arg Arg Lys Glu Leu Glu
             340                 345                 350        
 Met Glu Gln Gln Asn Glu Ala Ser Glu Glu Asn Asn Asp Gln Gln Ser
         355                 360                 365            
 Gln Glu Val Pro Glu Lys Val Thr Val Ser Ser Asp His Glu Glu Val
     370                 375                 380                
 Asp Asn Pro Glu Glu Lys Pro Glu Glu Glu Lys Glu Glu Val Ile Asp
 385                 390                 395                 400
 Asp Gln Glu Asn Leu Ala His Ser Arg Arg Thr Arg Glu Asp Arg Lys
                 405                 410                 415    
 Val Glu Ala Ile Met His Ala Phe Glu Asn Leu Glu Lys Arg Lys Lys
             420                 425                 430        
 Arg Arg Asp Gln Pro Leu Glu Gln Ser Asn Ser Asp Val Glu Ile Thr
         435                 440                 445            
 Thr Thr Thr Ser Glu Thr Pro Val Gly Glu Glu Thr Lys Thr Glu Ala
     450                 455                 460                
 Pro Glu Ser Glu Val Ser Asn Ser Val Ser Asn Val Thr Ile Pro Ser
 465                 470                 475                 480
 Thr Pro Gln Ser Val Gly Val Asn Thr Arg Arg Ser Ser Gln Ala Gly
                 485                 490                 495    
 Asp Ile Ala Ala Glu Lys Leu Val Pro Lys Pro Pro Pro Ala Lys Pro
             500                 505                 510        
 Ser Arg Pro Arg Pro Lys Ser Arg Ile Ser Arg Tyr Arg Thr Ser Ser
         515                 520                 525            
 Ala Gln Arg Leu Lys Arg Gln Lys Gln Ala Asn Ala Gln Gln Ala Glu
     530                 535                 540                
 Leu Ser Gln Ala Ala Leu Glu Glu Gly Gly Ser Asn Ser Leu Val Thr
 545                 550                 555                 560
 Pro Thr Glu Ala Gly Ser Leu Asp Ser Ser Gly Glu Asn Arg Pro Leu
                 565                 570                 575    
 Thr Gly Ser Asp Pro Thr Val Val Ser Ile Thr Gly Ser His Val Asn
             580                 585                 590        
 Arg Ala Ala Ser Lys Tyr Pro Lys Thr Lys Lys Tyr Leu Val Thr Glu
         595                 600                 605            
 Trp Leu Asn Asp Lys Ala Glu Lys Gln Glu Cys Pro Val Glu Cys Pro
     610                 615                 620                
 Leu Arg Ile Thr Thr Asp Pro Thr Val Leu Ala Thr Thr Leu Asn Met
 625                 630                 635                 640
 Leu Pro Gly Leu Ile His Ser Pro Leu Ile Cys Thr Thr Pro Lys His
                 645                 650                 655    
 Tyr Ile Arg Phe Gly Ser Pro Phe Ile Pro Glu Arg Arg Arg Arg Pro
             660                 665                 670        
 Leu Leu Pro Asp Gly Thr Phe Ser Pro Cys Lys Lys Arg Trp Ile Lys
         675                 680                 685            
 Gln Ala Leu Glu Glu Gly Met Thr Gln Thr Ser Ser Val Pro Gln Glu
     690                 695                 700                
 Thr Arg Thr Gln His Leu Tyr Gln Ser Asn Glu Asn Ser Ser Ser Ser
 705                 710                 715                 720
 Ser Ile Cys Lys Asp Asn Ala Asp Leu Leu Ser Pro Leu Lys Lys Trp
                 725                 730                 735    
 Lys Ser Arg Tyr Leu Met Glu Gln Asn Val Thr Lys Leu Leu Arg Pro
             740                 745                 750        
 Leu Ser Pro Val Thr Pro Pro Pro Pro Asn Ser Gly Ser Lys Ser Pro
         755                 760                 765            
 Gln Leu Ala Thr Pro Gly Ser Ser His Pro Gly Glu Glu Glu Cys Arg
     770                 775                 780                
 Asn Gly Tyr Ser Leu Met Phe Ser Pro Val Thr Ser Leu Thr Thr Ala
 785                 790                 795                 800
 Ser Arg Cys Asn Thr Pro Leu Gln Phe Glu Leu Cys His Arg Lys Asp
                 805                 810                 815    
 Leu Asp Leu Ala Lys Val Gly Tyr Leu Asp Ser Asn Thr Asn Ser Cys
             820                 825                 830        
 Ala Asp Arg Pro Ser Leu Leu Asn Ser Gly His Ser Asp Leu Ala Pro
         835                 840                 845            
 His Pro Ser Leu Gly Pro Thr Ser Glu Thr Gly Phe Pro Ser Arg Ser
     850                 855                 860                
 Gly Asp Gly His Gln Thr Leu Val Arg Asn Ser Asp Gln Ala Phe Arg
 865                 870                 875                 880
 Thr Glu Phe Asn Leu Met Tyr Ala Tyr Ser Pro Leu Asn Ala Met Pro
                 885                 890                 895    
 Arg Ala Asp Gly Leu Tyr Arg Gly Ser Pro Leu Val Gly Asp Arg Lys
             900                 905                 910        
 Pro Leu His Leu Asp Gly Gly Tyr Cys Ser Pro Ala Glu Gly Phe Ser
         915                 920                 925            
 Ser Arg Tyr Glu His Gly Leu Met Lys Asp Leu Ser Arg Gly Ser Leu
     930                 935                 940                
 Ser Pro Gly Gly Glu Arg Ala Cys Glu Gly Val Pro Ser Ala Pro Gln
 945                 950                 955                 960
 Asn Pro Pro Gln Arg Lys Lys Val Ser Leu Leu Glu Tyr Arg Lys Arg
                 965                 970                 975    
 Lys Gln Glu Ala Lys Glu Asn Ser Ala Gly Gly Gly Gly Asp Ser Ala
             980                 985                 990        
 Gln Ser Lys Ser Lys Ser Ala Gly Ala Gly Gln Gly Ser Ser Asn Ser
         995                1000                1005            
 Val Ser Asp Thr Gly Ala His Gly Val Gln Gly Ser Ser Ala Arg Thr
    1010                1015                1020                
 Pro Ser Ser Pro His Lys Lys Phe Ser Pro Ser His Ser Ser Met Ser
1025                1030                1035                1040
 His Leu Glu Ala Val Ser Pro Ser Asp Ser Arg Gly Thr Ser Ser Ser
                1045                1050                1055    
 His Cys Arg Pro Gln Glu Asn Ile Ser Ser Arg Trp Met Val Pro Thr
            1060                1065                1070        
 Ser Val Glu Arg Leu Arg Glu Gly Gly Ser Ile Pro Lys Val Leu Arg
        1075                1080                1085            
 Ser Ser Val Arg Val Ala Gln Lys Gly Glu Pro Ser Pro Thr Trp Glu
    1090                1095                1100                
 Ser Asn Ile Thr Glu Lys Asp Ser Asp Pro Ala Asp Gly Glu Gly Pro
1105                1110                1115                1120
 Glu Thr Leu Ser Ser Ala Leu Ser Lys Gly Ala Thr Val Tyr Ser Pro
                1125                1130                1135    
 Ser Arg Tyr Ser Tyr Gln Leu Leu Gln Cys Asp Ser Pro Arg Thr Glu
            1140                1145                1150        
 Ser Gln Ser Leu Leu Gln Gln Ser Ser Ser Pro Phe Arg Gly His Pro
        1155                1160                1165            
 Thr Gln Ser Pro Gly Tyr Ser Tyr Arg Thr Thr Ala Leu Arg Pro Gly
    1170                1175                1180                
 Asn Pro Pro Ser His Gly Ser Ser Glu Ser Ser Leu Ser Ser Thr Ser
1185                1190                1195                1200
 Tyr Ser Ser Pro Ala His Pro Val Ser Thr Asp Ser Leu Ala Pro Phe
                1205                1210                1215    
 Thr Gly Thr Pro Gly Tyr Phe Ser Ser Gln Pro His Ser Gly Asn Ser
            1220                1225                1230        
 Thr Gly Ser Asn Leu Pro Arg Arg Ser Cys Pro Ser Ser Ala Ala Ser
        1235                1240                1245            
 Pro Thr Leu Gln Gly Pro Ser Asp Ser Pro Thr Ser Asp Ser Val Ser
    1250                1255                1260                
 Gln Ser Ser Thr Gly Thr Leu Ser Ser Thr Ser Phe Pro Gln Asn Ser
1265                1270                1275                1280
 Arg Ser Ser Leu Pro Ser Asp Leu Arg Thr Ile Ser Leu Pro Ser Ala
                1285                1290                1295    
 Gly Gln Ser Ala Val Tyr Gln Ala Ser Arg Val Ser Ala Val Ser Asn
            1300                1305                1310        
 Ser Gln His Tyr Pro His Arg Gly Ser Gly Gly Val His Gln Tyr Arg
        1315                1320                1325            
 Leu Gln Pro Leu Gln Gly Ser Gly Val Lys Thr Gln Thr Gly Leu Ser
    1330                1335                1340                





      <210> 793
      <211> 161
      <212> PRT
      <213> Homo sapiens


      <400> 793
 Met Glu Tyr Thr Gly Ser Lys Tyr Ile Gly Glu Tyr Val Asp Gly Arg
   1               5                  10                  15    
 Met Glu Gly Lys Ala Lys Tyr Ile Leu Pro Thr Glu Thr Ile Tyr Val
              20                  25                  30        
 Gly Glu Met Lys Asp Gly Met Phe His Gly Glu Gly Thr Leu Tyr Phe
          35                  40                  45            
 Pro Ser Gly Ser Gln Tyr Asp Ala Ile Trp Glu Asn Gly Leu Ala Ile
      50                  55                  60                
 Lys Gly Thr Tyr Thr Phe Ser Asp Gly Leu His Tyr Asp Glu Lys Asn
  65                  70                  75                  80
 Trp His Tyr Cys Asp Gly Tyr Asp Arg Arg Phe Tyr Thr Glu Ile Leu
                  85                  90                  95    
 Asn Gly Leu Lys Pro Ala Gly Met Ala Gln Leu Thr Asn Met Asp Pro
             100                 105                 110        
 Pro Arg Lys Ile Pro Lys Gly Tyr Tyr Asp Cys Gly Asp Gly Phe Tyr
         115                 120                 125            
 Asn Pro Val Thr Arg Val Val Lys Asp Tyr Arg Asn Arg Phe Leu Arg
     130                 135                 140                
 Asn Ala Asp Asp Asp Glu His Glu Trp Ile Thr Arg Thr Cys Arg Lys
 145                 150                 155                 160
 Gly
    



      <210> 794
      <211> 190
      <212> PRT
      <213> Homo sapiens


      <400> 794
 Met Ala Ala Ser Lys Thr Gln Gly Ala Val Ala Arg Met Gln Glu Asp
   1               5                  10                  15    
 Arg Asp Gly Ser Cys Ser Thr Val Gly Gly Val Gly Tyr Gly Asp Ser
              20                  25                  30        
 Lys Asp Cys Ile Leu Glu Pro Leu Ser Leu Pro Glu Ser Pro Gly Gly
          35                  40                  45            
 Thr Thr Thr Leu Glu Gly Ser Pro Ser Val Pro Cys Ile Phe Cys Glu
      50                  55                  60                
 Glu His Phe Pro Val Ala Glu Gln Asp Lys Leu Leu Lys His Met Ile
  65                  70                  75                  80
 Ile Glu His Lys Ile Val Ile Ala Asp Val Lys Leu Val Ala Asp Phe
                  85                  90                  95    
 Gln Arg Tyr Ile Leu Tyr Trp Arg Lys Arg Phe Thr Glu Gln Pro Ile
             100                 105                 110        
 Thr Asp Phe Cys Ser Val Ile Arg Ile Asn Ser Thr Ala Pro Phe Glu
         115                 120                 125            
 Glu Gln Glu Asn Tyr Phe Leu Leu Cys Asp Val Leu Pro Glu Asp Arg
     130                 135                 140                
 Ile Leu Arg Glu Glu Leu Gln Lys Gln Arg Leu Ser Arg Asn Ser Gly
 145                 150                 155                 160
 Asn Asn Ser Ser Lys Asn Glu Met Ile Pro Ile Phe Met Ala Phe Val
                 165                 170                 175    
 Cys Phe Ala Met Lys Asn Ser Leu Glu Thr Asp Leu Leu Phe
             180                 185                 190



      <210> 795
      <211> 93
      <212> PRT
      <213> Homo sapiens


      <400> 795
 Met Ser Glu Asp Leu Arg Gln Ser Cys Arg Pro Lys Arg Arg Asp Pro
   1               5                  10                  15    
 Val Gly Ala Pro Ala Glu Gly Leu His Pro Ser Pro Ser Arg Pro Asp
              20                  25                  30        
 Ala Trp Ala Pro Gln Pro Ala Pro Trp Cys Gly Gly Leu Leu Gly Thr
          35                  40                  45            
 Leu Cys Ala Pro Ser Ala Gly Leu Arg Thr His Cys Ser Arg Arg Pro
      50                  55                  60                
 Arg Leu Trp Pro Met Ala Pro Ile Gln Val Gly Ile Arg Asp Leu Leu
  65                  70                  75                  80
 Pro Ala Gln Ser Ser Pro Glu Thr Ala Pro Trp Cys Gly
                  85                  90            



      <210> 796
      <211> 586
      <212> PRT
      <213> Homo sapiens


      <400> 796
 Met Gly Gly Cys Phe Ser Lys Pro Lys Pro Val Glu Leu Lys Ile Glu
   1               5                  10                  15    
 Val Val Leu Pro Glu Lys Glu Arg Gly Lys Glu Glu Leu Ser Ala Ser
              20                  25                  30        
 Gly Lys Gly Ser Pro Arg Ala Tyr Gln Gly Asn Gly Thr Ala Arg His
          35                  40                  45            
 Phe His Thr Glu Glu Arg Leu Ser Thr Pro His Pro Tyr Pro Ser Pro
      50                  55                  60                
 Gln Asp Cys Val Glu Ala Ala Val Cys His Val Lys Asp Leu Glu Asn
  65                  70                  75                  80
 Gly Gln Met Arg Glu Val Glu Leu Gly Trp Gly Lys Val Leu Leu Val
                  85                  90                  95    
 Lys Asp Asn Gly Glu Phe His Ala Leu Gly His Lys Cys Pro His Tyr
             100                 105                 110        
 Gly Ala Pro Leu Val Lys Gly Val Leu Ser Arg Gly Arg Val Arg Cys
         115                 120                 125            
 Pro Trp His Gly Ala Cys Phe Asn Ile Ser Thr Gly Asp Leu Glu Asp
     130                 135                 140                
 Phe Pro Gly Leu Asp Ser Leu His Lys Phe Gln Val Lys Ile Glu Lys
 145                 150                 155                 160
 Glu Lys Val Tyr Val Arg Ala Ser Lys Gln Ala Leu Gln Leu Gln Arg
                 165                 170                 175    
 Arg Thr Lys Val Met Ala Lys Cys Ile Ser Pro Ser Ala Gly Tyr Ser
             180                 185                 190        
 Ser Ser Thr Asn Val Leu Ile Val Gly Ala Gly Ala Ala Gly Leu Val
         195                 200                 205            
 Cys Ala Glu Thr Leu Arg Gln Glu Gly Phe Ser Asp Arg Ile Val Leu
     210                 215                 220                
 Cys Thr Leu Asp Arg His Leu Pro Tyr Asp Arg Pro Lys Leu Ser Lys
 225                 230                 235                 240
 Ser Leu Asp Thr Gln Pro Glu Gln Leu Ala Leu Arg Pro Lys Glu Phe
                 245                 250                 255    
 Phe Arg Ala Tyr Gly Ile Glu Val Leu Thr Glu Ala Gln Val Val Thr
             260                 265                 270        
 Val Asp Val Arg Thr Lys Lys Val Val Phe Lys Asp Gly Phe Lys Leu
         275                 280                 285            
 Glu Tyr Ser Lys Leu Leu Leu Ala Pro Gly Ser Ser Pro Lys Thr Leu
     290                 295                 300                
 Ser Cys Lys Gly Lys Glu Val Glu Asn Val Phe Thr Ile Arg Thr Pro
 305                 310                 315                 320
 Glu Asp Ala Asn Arg Val Val Arg Leu Ala Arg Gly Arg Asn Val Val
                 325                 330                 335    
 Val Val Gly Ala Gly Phe Leu Gly Met Glu Val Ala Ala Tyr Leu Thr
             340                 345                 350        
 Glu Lys Ala His Ser Val Ser Val Val Glu Leu Glu Glu Thr Pro Phe
         355                 360                 365            
 Arg Arg Phe Leu Gly Glu Arg Val Gly Arg Ala Leu Met Lys Met Phe
     370                 375                 380                
 Glu Asn Asn Arg Val Lys Phe Tyr Met Gln Thr Glu Val Ser Glu Leu
 385                 390                 395                 400
 Arg Gly Gln Glu Gly Lys Leu Lys Glu Val Val Leu Lys Ser Ser Lys
                 405                 410                 415    
 Val Val Arg Ala Asp Val Cys Val Val Gly Ile Gly Ala Val Pro Ala
             420                 425                 430        
 Thr Gly Phe Leu Arg Gln Ser Gly Ile Gly Leu Asp Ser Arg Gly Phe
         435                 440                 445            
 Ile Pro Val Asn Lys Met Met Gln Thr Asn Val Pro Gly Val Phe Ala
     450                 455                 460                
 Ala Gly Asp Ala Val Thr Phe Pro Leu Ala Trp Arg Asn Asn Arg Lys
 465                 470                 475                 480
 Val Asn Ile Pro His Trp Gln Met Ala His Ala Gln Gly Arg Val Ala
                 485                 490                 495    
 Ala Gln Asn Met Leu Ala Gln Glu Ala Glu Met Ser Thr Val Pro Tyr
             500                 505                 510        
 Leu Trp Thr Ala Met Phe Gly Lys Ser Leu Arg Tyr Ala Gly Tyr Gly
         515                 520                 525            
 Glu Gly Phe Asp Asp Val Ile Ile Gln Gly Asp Leu Glu Glu Leu Lys
     530                 535                 540                
 Phe Val Ala Phe Tyr Thr Lys Gly Asp Glu Val Ile Ala Val Ala Ser
 545                 550                 555                 560
 Met Asn Tyr Asp Pro Ile Val Ser Lys Val Ala Glu Val Leu Ala Ser
                 565                 570                 575    
 Gly Arg Ala Ile Arg Lys Arg Glu Val Glu
             580                 585    



      <210> 797
      <211> 464
      <212> PRT
      <213> Homo sapiens


      <400> 797
 Met Ala Ala Gln Pro Pro Arg Pro Val Gly Glu Arg Ser Met Gly Ser
   1               5                  10                  15    
 Ser Arg Glu Ala Ala Arg Ala Pro Ala Arg Ser Pro Ala Trp Ala Ser
              20                  25                  30        
 Thr Gln Ala Ser Thr Pro Gly Ala Ala Leu Ala Val Gln Arg Glu Ser
          35                  40                  45            
 Pro Glu Ser Gly Leu Gln Lys His Tyr Ser Asn Leu Cys Met Glu Lys
      50                  55                  60                
 Ser Gln Lys Ile Asn Pro Phe Ile Leu His Ile Leu Gln Glu Val Asp
  65                  70                  75                  80
 Glu Glu Ile Lys Lys Gly Leu Ala Ala Gly Ile Thr Leu Asn Ile Ala
                  85                  90                  95    
 Gly Asn Asn Arg Leu Val Pro Val Glu Arg Val Thr Gly Glu Asp Phe
             100                 105                 110        
 Trp Ile Leu Ser Lys Ile Leu Lys Asn Cys Leu Tyr Ile Asn Gly Leu
         115                 120                 125            
 Asp Val Gly Tyr Asn Leu Leu Cys Asp Val Gly Ala Tyr Tyr Ala Ala
     130                 135                 140                
 Lys Leu Leu Gln Lys Gln Leu Asn Leu Ile Tyr Leu Asn Leu Met Phe
 145                 150                 155                 160
 Asn Asp Ile Gly Pro Glu Gly Gly Glu Leu Ile Ala Lys Val Leu His
                 165                 170                 175    
 Lys Asn Arg Thr Leu Lys Tyr Leu Arg Met Thr Gly Asn Lys Ile Glu
             180                 185                 190        
 Asn Lys Gly Gly Met Phe Phe Ala Ala Met Leu Gln Ile Asn Ser Ser
         195                 200                 205            
 Leu Glu Lys Leu Asp Leu Gly Asp Cys Asp Leu Gly Met Gln Ser Val
     210                 215                 220                
 Ile Ala Phe Ala Thr Val Leu Thr Gln Asn Gln Ala Ile Lys Ala Ile
 225                 230                 235                 240
 Asn Leu Asn Arg Pro Ile Leu Tyr Ser Glu Gln Glu Glu Ser Thr Val
                 245                 250                 255    
 His Val Gly Arg Met Leu Lys Glu Asn His Cys Leu Val Ala Leu His
             260                 265                 270        
 Met Cys Lys His Asp Ile Lys Asn Ser Gly Ile Gln Gln Leu Cys Asp
         275                 280                 285            
 Ala Leu Tyr Leu Asn Ser Ser Leu Arg Tyr Leu Asp Val Ser Cys Asn
     290                 295                 300                
 Lys Ile Thr His Asp Gly Met Val Tyr Leu Ala Asp Val Leu Lys Ser
 305                 310                 315                 320
 Asn Thr Thr Leu Glu Val Ile Asp Leu Ser Phe Asn Arg Ile Glu Asn
                 325                 330                 335    
 Ala Gly Ala Asn Tyr Leu Ser Glu Thr Leu Thr Ser His Asn Arg Ser
             340                 345                 350        
 Leu Lys Ala Leu Ser Val Val Ser Asn Asn Ile Glu Gly Glu Gly Leu
         355                 360                 365            
 Val Ala Leu Ser Gln Ser Met Lys Thr Asn Leu Thr Phe Ser His Ile
     370                 375                 380                
 Tyr Ile Trp Gly Asn Lys Phe Asp Glu Ala Thr Cys Ile Ala Tyr Ser
 385                 390                 395                 400
 Asp Leu Ile Gln Met Gly Cys Leu Lys Pro Asp Asn Thr Asp Val Glu
                 405                 410                 415    
 Pro Phe Val Val Asp Gly Arg Val Tyr Leu Ala Glu Val Ser Asn Gly
             420                 425                 430        
 Leu Lys Lys His Tyr Tyr Trp Thr Ser Thr Tyr Gly Glu Ser Tyr Asp
         435                 440                 445            
 His Ser Ser Asn Ala Gly Phe Ala Leu Val Pro Val Gly Gln Gln Pro
     450                 455                 460                





      <210> 798
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 798
 Met Ser Glu Ile Leu Pro Tyr Ser Glu Asp Lys Met Gly Arg Phe Gly
   1               5                  10                  15    
 Ala Asp Pro Glu Gly Ser Asp Leu Ser Phe Ser Cys Arg Leu Gln Asp
              20                  25                  30        
 Thr Asn Ser Phe Phe Ala Gly Asn Gln Ala Lys Arg Pro Pro Lys Leu
          35                  40                  45            
 Gly Gln Ile Gly Arg Ala Lys Arg Val Val Ile Glu Asp Asp Arg Ile
      50                  55                  60                
 Asp Asp Val Leu Lys Gly Met Gly Glu Lys Pro Pro Ser Gly Val
  65                  70                  75                



      <210> 799
      <211> 583
      <212> PRT
      <213> Homo sapiens


      <400> 799
 Met Ser Ser Glu Gln Ser Ala Pro Gly Ala Ser Pro Arg Ala Pro Arg
   1               5                  10                  15    
 Pro Gly Thr Gln Lys Ser Ser Gly Ala Val Thr Lys Lys Gly Glu Arg
              20                  25                  30        
 Ala Ala Lys Glu Lys Pro Ala Thr Val Leu Pro Pro Val Gly Glu Glu
          35                  40                  45            
 Glu Pro Lys Ser Pro Glu Glu Tyr Gln Cys Ser Gly Val Leu Glu Thr
      50                  55                  60                
 Asp Phe Ala Glu Leu Cys Thr Arg Trp Gly Tyr Thr Asp Phe Pro Lys
  65                  70                  75                  80
 Val Val Asn Arg Pro Arg Pro His Pro Pro Phe Val Pro Ser Ala Ser
                  85                  90                  95    
 Leu Ser Glu Lys Ala Thr Leu Asp Asp Pro Arg Leu Ser Gly Ser Cys
             100                 105                 110        
 Ser Leu Asn Ser Leu Glu Ser Lys Tyr Val Phe Phe Arg Pro Thr Ile
         115                 120                 125            
 Gln Val Glu Leu Glu Gln Glu Asp Ser Lys Ser Val Lys Glu Ile Tyr
     130                 135                 140                
 Ile Arg Gly Trp Lys Val Glu Glu Arg Ile Leu Gly Val Phe Ser Lys
 145                 150                 155                 160
 Cys Leu Pro Pro Leu Thr Gln Leu Gln Ala Ile Asn Leu Trp Lys Val
                 165                 170                 175    
 Gly Leu Thr Asp Lys Thr Leu Thr Thr Phe Ile Glu Leu Leu Pro Leu
             180                 185                 190        
 Cys Ser Ser Thr Leu Arg Gly Ser Arg Ser Pro Ser Trp Leu Pro Gly
         195                 200                 205            
 Ala Leu Ala Leu Tyr Trp Gly Leu Ile Ser Pro Ala Leu Arg Lys Val
     210                 215                 220                
 Ser Leu Glu Gly Asn Pro Leu Pro Glu Gln Ser Tyr His Lys Leu Met
 225                 230                 235                 240
 Ala Leu Asp Ser Thr Ile Ala His Leu Ser Leu Arg Asn Asn Asn Ile
                 245                 250                 255    
 Asp Asp Arg Gly Ala Gln Leu Leu Gly Gln Ala Leu Ser Thr Leu His
             260                 265                 270        
 Ser Cys Asn Arg Thr Leu Val Ser Leu Asn Leu Gly Phe Asn His Ile
         275                 280                 285            
 Gly Asp Glu Gly Ala Gly Tyr Ile Ala Asp Gly Leu Arg Leu Asn Arg
     290                 295                 300                
 Ser Leu Leu Trp Leu Ser Leu Ala His Asn Arg Ile Gln Asp Lys Gly
 305                 310                 315                 320
 Ala Leu Lys Leu Ala Glu Val Leu Arg Ala Phe Glu Leu Thr His Thr
                 325                 330                 335    
 Glu Val Val Glu Arg Arg Arg Leu Leu Leu Glu Lys Gly Thr Gln Glu
             340                 345                 350        
 Arg Ser Arg Ser Pro Ser Ser Ser Arg His Gly Asp Ser Lys Thr Asp
         355                 360                 365            
 Arg Glu Lys Ser Gln Met Val Gly Ile Ser Asn Ser Ala Leu Val Asp
     370                 375                 380                
 Lys Thr Asp Lys Thr Gln Thr Met Lys Thr Pro Lys Gly Leu Gly Lys
 385                 390                 395                 400
 Lys Lys Glu Lys Ser Trp Glu Leu Ala Lys Lys Glu Glu Lys Leu Gly
                 405                 410                 415    
 Ser Gly Gln Ser Pro Thr Gln Gly Thr Pro Lys Lys Glu Asp Ala Thr
             420                 425                 430        
 Lys Ala Gly Lys Gly Lys Val Thr Ile Pro Glu Gln Lys Pro Ser Arg
         435                 440                 445            
 Ala Lys Gly Ile Lys Ile Gly Ser Arg Glu Lys Arg Ser Ile Leu Leu
     450                 455                 460                
 Glu Ser Glu Leu Val Val Glu Ala Thr Glu Val Val Asn Pro Leu Leu
 465                 470                 475                 480
 Glu Pro Val Glu His Arg Asp Gly Lys Val Phe Met Pro Gly Asn Lys
                 485                 490                 495    
 Val Leu Leu His Leu Asn Leu Ile Arg Asn Arg Ile Thr Glu Val Gly
             500                 505                 510        
 Leu Glu Gly Phe Leu Ala Thr Val Gln Tyr Gln Met Gln Phe Ser Lys
         515                 520                 525            
 Ala Lys Ser Ala Ser Lys Gly Pro Val Gly Leu Leu Trp Leu Ser Leu
     530                 535                 540                
 Ala Lys Asn Cys Phe Ala Pro Gln Cys Pro Ala Tyr Ala Ile Ile Gln
 545                 550                 555                 560
 Glu Leu Met Leu Pro Arg Asp Pro Ile Lys Ala Lys Leu Arg Glu Asp
                 565                 570                 575    
 Glu Ala Met Ala Phe Phe Pro
             580            



      <210> 800
      <211> 122
      <212> PRT
      <213> Homo sapiens


      <400> 800
 Met Ala Glu Pro Gly Gly Arg Gly Asp Tyr Arg Lys Asp Gly Arg Leu
   1               5                  10                  15    
 Pro Ser Leu Ser Arg Ser Pro Leu Ser Thr Thr Leu Gly Thr Ser Pro
              20                  25                  30        
 Ala Cys Gly Leu Glu Ile Pro Pro Thr Ser Gly Ala Arg Pro Asp Gly
          35                  40                  45            
 Ser Cys Ser Leu Pro Ala Pro Val Tyr His Phe Lys Ser Arg Gln Trp
      50                  55                  60                
 Lys Gly Met Gly Arg Gly His Arg Gln Arg Trp Arg Leu Gln Gly Arg
  65                  70                  75                  80
 Gly Asp Cys Asp Met Gly Cys Val Val Gln Ala Ser Gly Leu Phe Pro
                  85                  90                  95    
 Ala Glu Met Arg Glu Arg Thr Thr Lys Lys Met Ala Thr Ser Pro Leu
             100                 105                 110        
 Asp Leu Cys Ala Gly Ala Cys Trp Glu Met
         115                 120        



      <210> 801
      <211> 183
      <212> PRT
      <213> Homo sapiens


      <400> 801
 Met Lys Lys Val Lys Lys Lys Arg Ser Glu Ala Arg Arg His Arg Asp
   1               5                  10                  15    
 Ser Thr Ser Gln His Ala Ser Ser Asn Ser Thr Ser Gln Gln Pro Ser
              20                  25                  30        
 Pro Glu Ser Thr Pro Gln Gln Pro Ser Pro Glu Ser Thr Pro Gln His
          35                  40                  45            
 Ser Ser Leu Glu Thr Thr Ser Arg Gln Pro Ala Phe Gln Ala Leu Pro
      50                  55                  60                
 Ala Pro Glu Ile Arg Arg Ser Ser Cys Cys Leu Leu Ser Pro Asp Ala
  65                  70                  75                  80
 Asn Val Lys Ala Ala Pro Gln Ser Arg Lys Ala Gly Pro Leu Ile Arg
                  85                  90                  95    
 Ala Gly Pro His Ser Cys Ser Cys Ala Thr Cys Pro Cys Ser Ser Ala
             100                 105                 110        
 Cys Trp Arg Arg Leu Gly Leu Cys His Ser Arg Ile Phe Asp Val Leu
         115                 120                 125            
 Leu Pro Arg Asp Trp Gln Met Ala Pro Gly Arg Gly Leu Pro Asn Leu
     130                 135                 140                
 Leu Thr Phe Tyr Arg Lys Ser Ser Arg Lys Pro Ser Ser His Arg Asn
 145                 150                 155                 160
 Ala Cys Pro Pro Ser Pro Arg Asn Cys Gly Cys Gly Ser Gly Gly Ser
                 165                 170                 175    
 Arg Ser Cys Leu Leu His His
             180            



      <210> 802
      <211> 449
      <212> PRT
      <213> Homo sapiens


      <400> 802
 Met Ala Leu Asp Ile Leu Ala Met Ala Pro Leu Tyr Gln Ala Pro Ala
   1               5                  10                  15    
 Ile Asn Arg Ile Gly Pro Lys Thr Asp Pro Ser Lys Arg Pro Ala Asp
              20                  25                  30        
 Pro Leu Lys Pro Leu Val Leu Ser Arg Thr Lys Leu Thr Thr Ile Glu
          35                  40                  45            
 Ala Lys Arg Ile Met Ser Ile Leu Asp Glu Ala Ile Tyr Lys Val Glu
      50                  55                  60                
 Leu Val Thr Leu Leu Ser Tyr Val Ala Ser Asn Arg Glu Asp Met Glu
  65                  70                  75                  80
 Gly Met Leu Gly Glu Asp Val Met Arg Ala Val Arg Glu His Glu Asp
                  85                  90                  95    
 Leu Cys Gln Val Leu Leu Glu Asn Val Arg Cys Leu Lys Glu Lys Glu
             100                 105                 110        
 Arg Gln Leu Gln Glu Gln Lys Glu Ala Glu Glu Glu Gly Trp Leu Arg
         115                 120                 125            
 Asp Arg Leu Leu Ser Ile Glu Leu Gln Lys Ser Ser Leu Ser Pro Leu
     130                 135                 140                
 Met Gln Gln Ile Lys Asp Ser Thr Lys Asn Val Leu Arg Leu Leu Leu
 145                 150                 155                 160
 Ser Asn Pro Gln Ala Ala Arg Leu Leu Gln Met Gln Thr Gln Gly Arg
                 165                 170                 175    
 Ser Ala Glu Ala Gln Asn Phe Ile Asp Ser Leu Ile Glu Leu Arg Gly
             180                 185                 190        
 Phe Leu Phe Glu Lys Leu Leu Thr Ser Pro Met Glu Ala Arg Asp Lys
         195                 200                 205            
 Ala Gln Phe Leu Gln Asp Ile Ser Arg Gln Asn Ser Asn Asn Gln Gln
     210                 215                 220                
 Ile Ile Asp Thr Leu Glu Lys Glu Leu Ala Glu Arg Met Lys Asn Arg
 225                 230                 235                 240
 Asn Ala Glu Val Glu Lys Glu Asn Phe Val Ile Gln Glu Leu Lys Asn
                 245                 250                 255    
 His Leu His Gln Val Leu Lys Phe Ser Glu Asn Ser Leu Val Arg Thr
             260                 265                 270        
 Lys Gln Glu Ala Glu Lys Gln Gln Lys Ala Asp Phe Arg Ala Ser Gln
         275                 280                 285            
 Ala Arg Val Ala Lys Ile Gln Gln Glu Ile Leu Gln Leu Gln Ser Gln
     290                 295                 300                
 Phe Tyr Asn Leu Val Met Glu Asn Arg Glu Ala Glu Gln Ala Leu Arg
 305                 310                 315                 320
 Lys Lys Lys Tyr Lys Val Glu Thr Glu Ile Glu Asn Trp Ile Gln Lys
                 325                 330                 335    
 Tyr Asp Thr Glu Met Gly Glu Lys Gln Glu Glu Leu Glu Asp Leu Asp
             340                 345                 350        
 Ala Val His Arg Glu Glu Lys Ile Ser Leu Glu Glu Leu Arg Arg Arg
         355                 360                 365            
 His Lys Val Leu Val Gly Glu Phe Ala Gln Ile Arg Glu Glu Arg Glu
     370                 375                 380                
 Ile Asn Ser Lys Lys Arg Met Glu Ala Glu Gln Glu Met Val Arg Met
 385                 390                 395                 400
 Val Arg Ala Ala Thr Leu Ile Gln Ala Leu Trp Lys Gly Tyr Leu Val
                 405                 410                 415    
 Arg Ser Leu Leu Arg Ser Lys Lys Lys Arg Gly Lys Gly Lys Ala Lys
             420                 425                 430        
 Asp Lys Glu Lys Gly Lys Gln Lys Gly Lys Glu Lys Gly Lys Gly Lys
         435                 440                 445            
 Lys
    



      <210> 803
      <211> 667
      <212> PRT
      <213> Homo sapiens


      <400> 803
 Met Trp Trp Thr Ser Asp Ser Val Gln Arg Ser His Phe Ala Ser Trp
   1               5                  10                  15    
 Met Ala Arg Tyr Tyr Lys Asp Ser Leu His Cys Glu Trp Ile Ile Glu
              20                  25                  30        
 Ala Lys Pro Gly His Ser Ile Lys Ile Thr Phe Asp Arg Phe Gln Thr
          35                  40                  45            
 Glu Val Asn Tyr Asp Thr Leu Glu Val Arg Asp Gly Pro Ala Ser Ser
      50                  55                  60                
 Ser Pro Leu Ile Gly Glu Tyr His Gly Thr Gln Ala Pro Gln Phe Leu
  65                  70                  75                  80
 Ile Ser Thr Gly Asn Phe Met Tyr Leu Leu Phe Thr Thr Asp Asn Ser
                  85                  90                  95    
 Arg Ser Ser Ile Gly Phe Leu Ile His Tyr Glu Ser Val Thr Leu Glu
             100                 105                 110        
 Ser Asp Ser Cys Leu Asp Pro Gly Ile Pro Val Asn Gly His Arg His
         115                 120                 125            
 Gly Gly Asp Phe Gly Ile Arg Ser Thr Val Thr Phe Ser Cys Asp Pro
     130                 135                 140                
 Gly Tyr Thr Leu Ser Asp Asp Glu Pro Leu Val Cys Glu Arg Asn His
 145                 150                 155                 160
 Gln Trp Asn His Ala Leu Pro Ser Cys Asp Ala Leu Cys Gly Gly Tyr
                 165                 170                 175    
 Ile Gln Gly Lys Ser Gly Thr Val Leu Ser Pro Gly Phe Pro Asp Phe
             180                 185                 190        
 Tyr Pro Asn Ser Leu Asn Cys Thr Trp Thr Ile Glu Val Ser His Gly
         195                 200                 205            
 Lys Gly Val Gln Met Ile Phe His Thr Phe His Leu Glu Ser Ser His
     210                 215                 220                
 Asp Tyr Leu Leu Ile Thr Glu Asp Gly Ser Phe Ser Glu Pro Val Ala
 225                 230                 235                 240
 Arg Leu Thr Gly Ser Val Leu Pro His Thr Ile Lys Ala Gly Leu Phe
                 245                 250                 255    
 Gly Asn Phe Thr Ala Gln Leu Arg Phe Ile Ser Asp Phe Ser Ile Ser
             260                 265                 270        
 Tyr Glu Gly Phe Asn Ile Thr Phe Ser Glu Tyr Asp Leu Glu Pro Cys
         275                 280                 285            
 Asp Asp Pro Gly Val Pro Ala Phe Ser Arg Arg Ile Gly Phe His Phe
     290                 295                 300                
 Gly Val Gly Asp Ser Leu Thr Phe Ser Cys Phe Leu Gly Tyr Arg Leu
 305                 310                 315                 320
 Glu Gly Ala Thr Lys Leu Thr Cys Leu Gly Gly Gly Arg Arg Val Trp
                 325                 330                 335    
 Ser Ala Pro Leu Pro Arg Cys Val Ala Glu Cys Gly Ala Ser Val Lys
             340                 345                 350        
 Gly Asn Glu Gly Thr Leu Leu Ser Pro Asn Phe Pro Ser Asn Tyr Asp
         355                 360                 365            
 Asn Asn His Glu Cys Ile Tyr Lys Ile Glu Thr Glu Ala Gly Lys Gly
     370                 375                 380                
 Ile His Leu Arg Thr Arg Ser Phe Gln Leu Phe Glu Gly Asp Thr Leu
 385                 390                 395                 400
 Lys Val Tyr Asp Gly Lys Asp Ser Ser Ser Arg Pro Leu Gly Thr Phe
                 405                 410                 415    
 Thr Lys Asn Glu Leu Leu Gly Leu Ile Leu Asn Ser Thr Ser Asn His
             420                 425                 430        
 Leu Trp Leu Glu Phe Asn Thr Asn Gly Ser Asp Thr Asp Gln Gly Phe
         435                 440                 445            
 Gln Leu Thr Tyr Thr Ser Phe Asp Leu Val Lys Cys Glu Asp Pro Gly
     450                 455                 460                
 Ile Pro Asn Tyr Gly Tyr Arg Ile Arg Asp Glu Gly His Phe Thr Asp
 465                 470                 475                 480
 Thr Val Val Leu Tyr Ser Cys Asn Pro Gly Tyr Ala Met His Gly Ser
                 485                 490                 495    
 Asn Thr Leu Thr Cys Leu Ser Gly Asp Arg Arg Val Trp Asp Lys Pro
             500                 505                 510        
 Leu Pro Ser Cys Ile Ala Glu Cys Gly Gly Gln Ile His Ala Ala Thr
         515                 520                 525            
 Ser Gly Arg Ile Leu Ser Pro Gly Tyr Pro Ala Pro Tyr Asp Asn Asn
     530                 535                 540                
 Leu His Cys Thr Trp Ile Ile Glu Ala Asp Pro Gly Lys Thr Ile Ser
 545                 550                 555                 560
 Leu His Phe Ile Val Phe Asp Thr Glu Met Ala His Asp Ile Leu Lys
                 565                 570                 575    
 Val Trp Asp Gly Pro Val Asp Ser Asp Ile Leu Leu Lys Glu Trp Ser
             580                 585                 590        
 Gly Ser Ala Leu Pro Glu Asp Ile His Ser Thr Phe Asn Ser Leu Thr
         595                 600                 605            
 Leu Gln Phe Asp Ser Asp Phe Phe Ile Ser Lys Ser Gly Phe Ser Ile
     610                 615                 620                
 Gln Phe Ser Ser Phe Arg Arg Arg Lys Glu Trp Arg Tyr Phe Val Ala
 625                 630                 635                 640
 Val Gln Pro Phe Ser Ala Leu Arg Met Ala Pro Trp Arg Asp Ala Ile
                 645                 650                 655    
 Leu Leu Gly Ser Thr Gln Gly Gln Pro Ser Ser
             660                 665        



      <210> 804
      <211> 135
      <212> PRT
      <213> Homo sapiens


      <400> 804
 Met Ala Gly His Pro Lys Glu Lys Val Ile Pro Asp Glu Val His Gln
   1               5                  10                  15    
 Asn Gln Ile Leu Arg Glu Leu Tyr Leu Lys Glu Leu Arg Thr Gln Lys
              20                  25                  30        
 Leu Tyr Thr Gln Tyr His Val Asn Pro Leu Arg Lys Ile His Thr Val
          35                  40                  45            
 Thr Arg Lys Pro Met Ser Trp His Asp Asn Leu Glu Glu Pro Ala Asp
      50                  55                  60                
 Ala Arg Phe Leu Asn Leu Ile His His Ala Ala Gln Gly Pro Thr Lys
  65                  70                  75                  80
 Lys Tyr Pro Glu Ala Gln Thr Glu Asn Gln Glu Ile Gly Trp Asp Ser
                  85                  90                  95    
 Glu Ala Leu Val Asp Pro Glu Arg Arg Asp His Arg Met Asn His Phe
             100                 105                 110        
 Arg Val Tyr Ser Asp Ile Thr Leu Tyr Lys Ala Lys Met Trp Ser Leu
         115                 120                 125            
 Gly Glu Asp Asp Arg His Lys
     130                 135



      <210> 805
      <211> 785
      <212> PRT
      <213> Homo sapiens


      <400> 805
 Met Asn Ser Ser Ser Arg Ser Gln Ile Leu Leu Arg Trp Lys Ser Asp
   1               5                  10                  15    
 Lys Ala Gln Ser Gly Pro Tyr Asn Val Glu Lys Glu Ile Leu Thr Ser
              20                  25                  30        
 Arg Phe Leu Arg Asp Thr Glu Thr Cys Arg Gln Asn Phe Arg Asn Phe
          35                  40                  45            
 Pro Tyr Pro Asp Leu Ala Gly Pro Arg Lys Ala Leu Ser Gln Leu Arg
      50                  55                  60                
 Glu Leu Cys Leu Lys Trp Leu Arg Pro Glu Ile His Ser Lys Glu Gln
  65                  70                  75                  80
 Ile Leu Glu Leu Leu Val Leu Glu Gln Phe Leu Thr Ile Leu Pro Gly
                  85                  90                  95    
 Glu Val Arg Thr Trp Val Lys Ser Gln Tyr Pro Glu Ser Ser Glu Glu
             100                 105                 110        
 Ala Val Thr Leu Val Glu Asp Leu Thr Gln Ile Leu Glu Glu Glu Ala
         115                 120                 125            
 Pro Gln Asn Ser Thr Leu Ser Gln Asp Thr Pro Glu Glu Asp Pro Arg
     130                 135                 140                
 Gly Lys His Ala Phe Gln Thr Gly Trp Leu Asn Asp Leu Val Thr Lys
 145                 150                 155                 160
 Glu Ser Met Thr Phe Lys Asp Val Ala Val Asp Ile Thr Gln Glu Asp
                 165                 170                 175    
 Trp Glu Leu Met Arg Pro Val Gln Lys Glu Leu Tyr Lys Thr Val Thr
             180                 185                 190        
 Leu Gln Asn Tyr Trp Asn Met Val Ser Leu Gly Leu Thr Val Tyr Arg
         195                 200                 205            
 Pro Thr Val Ile Pro Ile Leu Glu Glu Pro Trp Met Val Ile Lys Glu
     210                 215                 220                
 Ile Leu Glu Gly Pro Ser Pro Gly Gly Glu Gly Ile Val Lys Glu Gly
 225                 230                 235                 240
 Leu Glu Ser Arg Ile Ser Met Ala Ser Arg Glu Asp Tyr Glu Glu Val
                 245                 250                 255    
 Val Asp Asn Phe Arg Pro Glu Trp Glu Thr Lys Ala Gln Ala Cys Thr
             260                 265                 270        
 Pro Val Glu Asp Met Ser Lys Leu Thr Lys Glu Glu Thr His Thr Ile
         275                 280                 285            
 Lys Leu Glu Asp Ser Tyr Asp Tyr Asp Asp Arg Leu Glu Arg Arg Gly
     290                 295                 300                
 Lys Gly Gly Phe Trp Lys Ile His Thr Asp Glu Arg Gly Phe Ser Leu
 305                 310                 315                 320
 Lys Ser Val Leu Ser Gln Glu Tyr Asp Pro Thr Glu Glu Cys Leu Ser
                 325                 330                 335    
 Lys Tyr Asp Ile Tyr Arg Asn Asn Phe Glu Lys His Ser Asn Leu Ile
             340                 345                 350        
 Val Gln Phe Asp Thr Gln Leu Asp Asn Lys Thr Ser Val Tyr Asn Glu
         355                 360                 365            
 Gly Arg Ala Thr Phe Asn His Val Ser Tyr Gly Ile Val His Arg Lys
     370                 375                 380                
 Ile Leu Pro Gly Glu Lys Pro Tyr Lys Cys Asn Val Cys Gly Lys Lys
 385                 390                 395                 400
 Phe Arg Lys Tyr Pro Ser Leu Leu Lys His Gln Ser Thr His Ala Lys
                 405                 410                 415    
 Glu Lys Ser Tyr Glu Cys Glu Glu Cys Gly Lys Glu Phe Arg His Ile
             420                 425                 430        
 Ser Ser Leu Ile Ala His Gln Arg Met His Thr Gly Glu Lys Pro Tyr
         435                 440                 445            
 Glu Cys His Gln Cys Gly Lys Ala Phe Ser Gln Arg Ala His Leu Thr
     450                 455                 460                
 Ile His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Asp
 465                 470                 475                 480
 Cys Gly Lys Asp Phe Ser Gln Arg Ala His Leu Thr Ile His Gln Arg
                 485                 490                 495    
 Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Leu Glu Cys Gly Lys Thr
             500                 505                 510        
 Phe Ser His Ser Ser Ser Leu Ile Asn His Gln Arg Val His Thr Gly
         515                 520                 525            
 Glu Lys Pro Tyr Ile Cys Asn Glu Cys Gly Lys Thr Phe Ser Gln Ser
     530                 535                 540                
 Thr His Leu Leu Gln His Gln Lys Ile His Thr Gly Lys Lys Pro Tyr
 545                 550                 555                 560
 Lys Cys Asn Glu Cys Trp Lys Val Phe Ser Gln Ser Thr Tyr Leu Ile
                 565                 570                 575    
 Arg His Gln Arg Ile His Ser Gly Glu Lys Cys Tyr Lys Cys Asn Glu
             580                 585                 590        
 Cys Gly Lys Ala Phe Ala His Ser Ser Thr Leu Ile Gln His Gln Thr
         595                 600                 605            
 Thr His Thr Gly Glu Lys Ser Tyr Ile Cys Asn Ile Cys Gly Lys Ala
     610                 615                 620                
 Phe Ser Gln Ser Ala Asn Leu Thr Gln His His Arg Thr His Thr Gly
 625                 630                 635                 640
 Glu Lys Pro Tyr Lys Cys Ser Val Cys Gly Lys Ala Phe Ser Gln Ser
                 645                 650                 655    
 Val His Leu Thr Gln His Gln Arg Ile His Asn Gly Glu Lys Pro Phe
             660                 665                 670        
 Lys Cys Asn Ile Cys Gly Lys Ala Tyr Arg Gln Gly Ala Asn Leu Thr
         675                 680                 685            
 Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu
     690                 695                 700                
 Cys Gly Lys Ala Phe Ile Tyr Ser Ser Ser Leu Asn Gln His Gln Arg
 705                 710                 715                 720
 Thr His Thr Gly Glu Arg Pro Tyr Lys Cys Asn Glu Cys Asp Lys Asp
                 725                 730                 735    
 Phe Ser Gln Arg Thr Cys Leu Ile Gln His Gln Arg Ile His Thr Gly
             740                 745                 750        
 Glu Lys Pro Tyr Ala Cys Arg Ile Cys Gly Lys Thr Phe Thr Gln Ser
         755                 760                 765            
 Thr Asn Leu Ile Gln His Gln Arg Val His Thr Gly Ala Lys His Arg
     770                 775                 780                
 Asn
 785



      <210> 806
      <211> 217
      <212> PRT
      <213> Homo sapiens


      <400> 806
 Met Ile Asn His Leu Ser Pro His Gln Ala Ala Ala Pro Val Asp Gln
   1               5                  10                  15    
 Thr Pro Arg Thr Leu Ala Thr Met Gly Gln Arg Ala Leu Pro Ser Ser
              20                  25                  30        
 Leu Ala Leu Leu Ser Arg Pro Leu Ser Pro Pro Pro Ala Ala Cys Ser
          35                  40                  45            
 Gly Asp Pro Gly Cys Gly Ser Gly Ala Gly Leu Pro Ser Ala Ser Ala
      50                  55                  60                
 Ala Ala Gly Ile Ala Ser Ser Ala Val Glu Pro Val Cys Gly Asp Ala
  65                  70                  75                  80
 Ala Pro Ala Cys Leu Leu Arg Thr Pro Leu Arg Gly Leu Leu Lys Pro
                  85                  90                  95    
 Thr Gly Pro Arg Ser Thr Met Glu Cys Pro Pro Ala Leu Ile Val His
             100                 105                 110        
 Pro Pro Ala Gly Gly Met Ala Ser Gly Ser Ser Gln Pro Trp Ala Ala
         115                 120                 125            
 Ala Ser Ala Thr Pro Met Leu Ser Ser Lys Ala Ser Leu Cys Ile Pro
     130                 135                 140                
 Thr Arg Gly Pro Pro Pro Gln Pro Leu Met Arg Thr Pro Ala Ala Arg
 145                 150                 155                 160
 Ser His Trp Pro Ile Pro His Pro Cys Asp Thr Ala Cys Pro Ala Pro
                 165                 170                 175    
 Leu Pro Val Val Leu Val Ala Pro Arg Ser Thr Ile Leu Ser Met Ser
             180                 185                 190        
 Arg Thr Trp Thr Cys Arg Arg Trp Ala Val Ala Pro Cys Arg Ala Glu
         195                 200                 205            
 Lys Leu Met Cys Ser Ser Ser Arg Ser
     210                 215        



      <210> 807
      <211> 1339
      <212> PRT
      <213> Homo sapiens


      <400> 807
 Met Thr Lys Arg Lys Lys Thr Ile Asn Leu Asn Ile Gln Asp Ala Gln
   1               5                  10                  15    
 Lys Arg Thr Ala Leu His Trp Ala Cys Val Asn Gly His Val Glu Val
              20                  25                  30        
 Val Thr Leu Leu Val Asp Arg Lys Cys Gln Leu Asp Val Leu Asp Gly
          35                  40                  45            
 Glu Asn Arg Thr Pro Leu Met Lys Ala Leu Gln Cys His Gln Glu Ala
      50                  55                  60                
 Cys Ala Asn Ile Leu Ile Asp Ser Gly Ala Asp Ile Asn Leu Val Asp
  65                  70                  75                  80
 Val Tyr Gly Asn Met Ala Leu His Tyr Ala Val Tyr Ser Glu Ile Leu
                  85                  90                  95    
 Ser Val Val Ala Lys Leu Leu Ser His Gly Ala Val Ile Glu Val His
             100                 105                 110        
 Asn Lys Ala Ser Leu Thr Pro Leu Leu Leu Ala Ile Thr Lys Arg Ser
         115                 120                 125            
 Glu Gln Ile Val Glu Phe Leu Leu Thr Lys Asn Ala Asn Ala Asn Ala
     130                 135                 140                
 Val Asn Lys Tyr Lys Cys Thr Ala Leu Met Leu Ala Val Cys His Gly
 145                 150                 155                 160
 Ser Ser Glu Ile Val Gly Ile Leu Leu Gln Gln Asn Ile Asp Ile Cys
                 165                 170                 175    
 Ala Glu Asp Met Cys Gly Met Thr Ala Glu His Tyr Ala Val Thr Cys
             180                 185                 190        
 Gly Phe His His Ile His Glu Gln Ile Met Glu Tyr Ile Arg Lys Leu
         195                 200                 205            
 Ser Lys Asn His Gln Asn Thr Asn Pro Glu Gly Thr Ser Ala Gly Thr
     210                 215                 220                
 Pro Asp Glu Ala Ala Pro Leu Ala Glu Arg Thr Pro Asp Thr Ala Glu
 225                 230                 235                 240
 Ser Leu Val Glu Lys Thr Pro Asp Glu Ala Ala Pro Leu Ala Glu Arg
                 245                 250                 255    
 Thr Pro Asp Thr Ala Glu Ser Leu Val Glu Lys Thr Pro Asp Glu Ala
             260                 265                 270        
 Ala Pro Leu Val Glu Gly Thr Ser Asp Lys Ile Gln Cys Leu Gly Lys
         275                 280                 285            
 Ala Thr Ser Gly Lys Phe Glu Gln Ser Ala Glu Glu Thr Pro Arg Glu
     290                 295                 300                
 Ile Thr Ser Pro Ala Lys Glu Thr Ser Glu Lys Phe Thr Trp Pro Ala
 305                 310                 315                 320
 Lys Gly Arg Pro Arg Lys Ile Ala Trp Glu Lys Lys Glu Asp Thr Pro
                 325                 330                 335    
 Arg Glu Ile Met Ser Pro Ala Lys Glu Thr Ser Glu Lys Phe Thr Trp
             340                 345                 350        
 Ala Ala Lys Gly Arg Pro Arg Lys Ile Ala Trp Glu Lys Lys Glu Thr
         355                 360                 365            
 Pro Val Lys Thr Gly Cys Val Ala Arg Val Thr Ser Asn Lys Thr Lys
     370                 375                 380                
 Val Leu Glu Lys Gly Arg Ser Lys Met Ile Ala Cys Pro Thr Lys Glu
 385                 390                 395                 400
 Ser Ser Thr Lys Ala Ser Ala Asn Asp Gln Arg Phe Pro Ser Glu Ser
                 405                 410                 415    
 Lys Gln Glu Glu Asp Glu Glu Tyr Ser Cys Asp Ser Arg Ser Leu Phe
             420                 425                 430        
 Glu Ser Ser Ala Lys Ile Gln Val Cys Ile Pro Glu Ser Ile Tyr Gln
         435                 440                 445            
 Lys Val Met Glu Ile Asn Arg Glu Val Glu Glu Pro Pro Lys Lys Pro
     450                 455                 460                
 Ser Ala Phe Lys Pro Ala Ile Glu Met Gln Asn Ser Val Pro Asn Lys
 465                 470                 475                 480
 Ala Phe Glu Leu Lys Asn Glu Gln Thr Leu Arg Ala Asp Pro Met Phe
                 485                 490                 495    
 Pro Pro Glu Ser Lys Gln Lys Asp Tyr Glu Glu Asn Ser Trp Asp Ser
             500                 505                 510        
 Glu Ser Leu Cys Glu Thr Val Ser Gln Lys Asp Val Cys Leu Pro Lys
         515                 520                 525            
 Ala Thr His Gln Lys Glu Ile Asp Lys Ile Asn Gly Lys Leu Glu Glu
     530                 535                 540                
 Ser Pro Asn Lys Asp Gly Leu Leu Lys Ala Thr Cys Gly Met Lys Val
 545                 550                 555                 560
 Ser Ile Pro Thr Lys Ala Leu Glu Leu Lys Asp Met Gln Thr Phe Lys
                 565                 570                 575    
 Ala Glu Pro Pro Gly Lys Pro Ser Ala Phe Glu Pro Ala Thr Glu Met
             580                 585                 590        
 Gln Lys Ser Val Pro Asn Lys Ala Leu Glu Leu Lys Asn Glu Gln Thr
         595                 600                 605            
 Trp Arg Ala Asp Glu Ile Leu Pro Ser Glu Ser Lys Gln Lys Asp Tyr
     610                 615                 620                
 Glu Glu Asn Ser Trp Asp Thr Glu Ser Leu Cys Glu Thr Val Ser Gln
 625                 630                 635                 640
 Lys Asp Val Cys Leu Pro Lys Ala Ala His Gln Lys Glu Ile Asp Lys
                 645                 650                 655    
 Ile Asn Gly Lys Leu Glu Gly Ser Pro Val Lys Asp Gly Leu Leu Lys
             660                 665                 670        
 Ala Asn Cys Gly Met Lys Val Ser Ile Pro Thr Lys Ala Leu Glu Leu
         675                 680                 685            
 Met Asp Met Gln Thr Phe Lys Ala Glu Pro Pro Glu Lys Pro Ser Ala
     690                 695                 700                
 Phe Glu Pro Ala Ile Glu Met Gln Lys Ser Val Pro Asn Lys Ala Leu
 705                 710                 715                 720
 Glu Leu Lys Asn Glu Gln Thr Leu Arg Ala Asp Glu Ile Leu Pro Ser
                 725                 730                 735    
 Glu Ser Lys Gln Lys Asp Tyr Glu Glu Ser Ser Trp Asp Ser Glu Ser
             740                 745                 750        
 Leu Cys Glu Thr Val Ser Gln Lys Asp Val Cys Leu Pro Lys Ala Thr
         755                 760                 765            
 His Gln Lys Glu Ile Asp Lys Ile Asn Gly Lys Leu Glu Glu Ser Pro
     770                 775                 780                
 Asp Asn Asp Gly Phe Leu Lys Ala Pro Cys Arg Met Lys Val Ser Ile
 785                 790                 795                 800
 Pro Thr Lys Ala Leu Glu Leu Met Asp Met Gln Thr Phe Lys Ala Glu
                 805                 810                 815    
 Pro Pro Glu Lys Pro Ser Ala Phe Glu Pro Ala Ile Glu Met Gln Lys
             820                 825                 830        
 Ser Val Pro Asn Lys Ala Leu Glu Leu Lys Asn Glu Gln Thr Leu Arg
         835                 840                 845            
 Ala Asp Gln Met Phe Pro Ser Glu Ser Lys Gln Lys Lys Val Glu Glu
     850                 855                 860                
 Asn Ser Trp Asp Ser Glu Ser Leu Arg Glu Thr Val Ser Gln Lys Asp
 865                 870                 875                 880
 Val Cys Val Pro Lys Ala Thr His Gln Lys Glu Met Asp Lys Ile Ser
                 885                 890                 895    
 Gly Lys Leu Glu Asp Ser Thr Ser Leu Ser Lys Ile Leu Asp Thr Val
             900                 905                 910        
 His Ser Cys Glu Arg Ala Arg Glu Leu Gln Lys Asp His Cys Glu Gln
         915                 920                 925            
 Arg Thr Gly Lys Met Glu Gln Met Lys Lys Lys Phe Cys Val Leu Lys
     930                 935                 940                
 Lys Lys Leu Ser Glu Ala Lys Glu Ile Lys Ser Gln Leu Glu Asn Gln
 945                 950                 955                 960
 Lys Val Lys Trp Glu Gln Glu Leu Cys Ser Val Arg Leu Thr Leu Asn
                 965                 970                 975    
 Gln Glu Glu Glu Lys Arg Arg Asn Ala Asp Ile Leu Lys Glu Lys Ile
             980                 985                 990        
 Arg Glu Glu Leu Gly Arg Ile Glu Glu Gln Leu Arg Lys Lys Leu Glu
         995                1000                1005            
 Val Lys Gln Gln Leu Glu Gln Ala Leu Arg Ile Gln Asp Ile Glu Leu
    1010                1015                1020                
 Lys Ser Val Thr Ser Asn Leu Asn Gln Val Ser His Thr His Glu Ser
1025                1030                1035                1040
 Glu Asn Asp Leu Phe His Glu Asn Cys Met Leu Lys Lys Glu Ile Ala
                1045                1050                1055    
 Met Leu Lys Leu Glu Val Ala Thr Leu Lys His Gln His Gln Glu Lys
            1060                1065                1070        
 Glu Asn Lys Tyr Phe Glu Asp Ile Lys Ile Leu Gln Glu Lys Asn Ala
        1075                1080                1085            
 Glu Leu Gln Met Thr Leu Lys Leu Lys Gln Lys Thr Leu Thr Lys Arg
    1090                1095                1100                
 Ala Ser Gln Tyr Arg Glu Gln Leu Lys Val Leu Thr Ala Glu Asn Thr
1105                1110                1115                1120
 Met Leu Thr Ser Lys Leu Lys Glu Lys Gln Asp Lys Glu Ile Leu Glu
                1125                1130                1135    
 Thr Glu Ile Glu Ser His His Pro Arg Leu Ala Ser Ala Leu Gln Asp
            1140                1145                1150        
 His Asp Gln Ser Val Thr Ser Arg Lys Asn Gln Glu Leu Ala Phe His
        1155                1160                1165            
 Ser Ala Gly Asp Ala His Leu Gln Gly Ile Met Asn Val Asp Val Ser
    1170                1175                1180                
 Asn Thr Ile Tyr Asn Asn Glu Val Leu His Gln Pro Leu Tyr Glu Ala
1185                1190                1195                1200
 Gln Arg Lys Ser Lys Ser Pro Lys Ile Asn Leu Asn Tyr Ala Gly Asp
                1205                1210                1215    
 Asp Leu Arg Glu Asn Ala Leu Val Ser Glu His Ala Gln Arg Asp Arg
            1220                1225                1230        
 Cys Glu Thr Gln Cys Gln Met Lys Lys Ala Glu His Met Tyr Gln Asn
        1235                1240                1245            
 Glu Gln Asp Asn Val Asp Lys His Thr Glu Gln Gln Glu Ser Leu Glu
    1250                1255                1260                
 Gln Lys Leu Phe Gln Leu Glu Ser Lys Asn Arg Trp Leu Arg Gln Gln
1265                1270                1275                1280
 Leu Val Tyr Ala His Lys Lys Val Asn Lys Ser Lys Val Thr Ile Asn
                1285                1290                1295    
 Ile Gln Phe Pro Glu Thr Lys Met Gln Arg His Leu Lys Glu Lys Asn
            1300                1305                1310        
 Glu Glu Val Phe Asn Tyr Gly Asn His Leu Lys Glu Arg Ile Asp Gln
        1315                1320                1325            
 Tyr Glu Lys Glu Lys Ala Glu Arg Glu Asn Ser
    1330                1335                



      <210> 808
      <211> 260
      <212> PRT
      <213> Homo sapiens


      <400> 808
 Met Arg Ala Glu Ser Ser Gln Cys Lys Gly Arg Ala Thr Lys Thr Thr
   1               5                  10                  15    
 Ser Gln Lys Pro Glu Leu Gly Gln Ser Leu Gly Ser Arg Gln Leu Pro
              20                  25                  30        
 Ala Ala Gly Ala Ala Glu Arg Lys Ala Arg Pro Leu Arg Val Arg Phe
          35                  40                  45            
 Gly Pro Ala Pro Pro Ala Pro Pro Ala Pro Ala Thr Gly Thr Trp Tyr
      50                  55                  60                
 Gly Arg Ala Val Gly Val Leu Cys Gly Ser Cys Gln Gly Arg Ala Phe
  65                  70                  75                  80
 Gln Ile Phe Pro Leu Lys Glu Trp Arg Arg Pro Gly Gln Phe Ala Leu
                  85                  90                  95    
 Glu Met Glu Gly Pro Ser Leu Arg Gly Pro Ala Leu Arg Leu Ala Gly
             100                 105                 110        
 Leu Pro Thr Gln Gln Asp Cys Asn Ile Gln Glu Lys Ile Asp Leu Glu
         115                 120                 125            
 Ile Arg Met Arg Glu Gly Ile Trp Lys Leu Leu Ser Leu Ser Thr Gln
     130                 135                 140                
 Lys Asp Gln Val Leu His Ala Val Lys Asn Leu Met Val Cys Asn Ala
 145                 150                 155                 160
 Arg Leu Met Ala Tyr Thr Ser Glu Leu Gln Lys Leu Glu Glu Gln Ile
                 165                 170                 175    
 Ala Asn Gln Thr Gly Arg Cys Asp Val Lys Phe Glu Ser Lys Glu Arg
             180                 185                 190        
 Thr Ala Cys Lys Gly Lys Ile Ala Ile Ser Asp Ile Arg Ile Pro Leu
         195                 200                 205            
 Met Trp Lys Asp Ser Asp His Phe Ser Asn Lys Glu Arg Ser Arg Arg
     210                 215                 220                
 Tyr Ala Ile Phe Cys Leu Phe Lys Met Gly Ala Asn Val Phe Asp Thr
 225                 230                 235                 240
 Asp Val Val Asn Val Asp Lys Thr Ile Thr Asp Ile Cys Phe Glu Asn
                 245                 250                 255    
 Val Thr Ile Leu
             260



      <210> 809
      <211> 311
      <212> PRT
      <213> Homo sapiens


      <400> 809
 Met Ala Arg Pro Gln Pro Cys Gly Pro Pro His Ala Arg Cys Gly Ser
   1               5                  10                  15    
 Pro Ser Leu Pro Glu Arg Pro Leu Gln Val Lys Val Val Gly Leu Phe
              20                  25                  30        
 Ser Cys Pro Asn Phe Gln Ile Ala Lys Ser Ala Ala Glu Asn Leu Lys
          35                  40                  45            
 Asn Asn His Pro Ser Lys Phe Glu Asp Pro Ile Leu Val Pro Leu Gln
      50                  55                  60                
 Glu Phe Ala Trp His Gln Tyr Leu Gln Glu Lys Lys Arg Glu Leu Lys
  65                  70                  75                  80
 Asn Glu Thr Trp Glu Tyr Ser Ser Ser Val Ile Ser Phe Val Asn Gly
                  85                  90                  95    
 Gln Phe Leu Gly Asp Ala Leu Asp Leu Gln Lys Trp Ala His Glu Val
             100                 105                 110        
 Trp Asp Ile Val Asp Ile Lys Pro Ser Ala Leu Tyr Asp Ala Leu Thr
         115                 120                 125            
 Glu Asp Phe Ser Ala Lys Phe Leu Arg Asp Thr Lys His Asp Phe Val
     130                 135                 140                
 Phe Leu Asp Ile Cys Ile Asp Ser Ser Pro Ile Gly Arg Leu Ile Phe
 145                 150                 155                 160
 Glu Leu Tyr Cys Asp Val Cys Pro Lys Thr Cys Lys Asn Phe Gln Val
                 165                 170                 175    
 Leu Cys Thr Gly Lys Ala Gly Phe Ser Gln Arg Gly Ile Arg Leu His
             180                 185                 190        
 Tyr Lys Asn Ser Ile Phe His Arg Ile Val Gln Asn Gly Trp Ile Gln
         195                 200                 205            
 Gly Gly Asp Ile Val Tyr Gly Lys Gly Asp Asn Gly Glu Ser Ile Tyr
     210                 215                 220                
 Gly Pro Thr Phe Glu Asp Glu Asn Phe Ser Val Pro His Asn Lys Arg
 225                 230                 235                 240
 Gly Val Leu Gly Met Ala Asn Lys Gly Arg His Ser Asn Gly Ser Gln
                 245                 250                 255    
 Phe Tyr Ile Thr Leu Gln Ala Thr Pro Tyr Leu Asp Arg Lys Phe Val
             260                 265                 270        
 Ala Phe Gly Gln Leu Ile Glu Gly Thr Glu Val Leu Lys Gln Leu Glu
         275                 280                 285            
 Leu Val Pro Thr Gln Asn Glu Arg Pro Ile His Met Cys Arg Ile Thr
     290                 295                 300                
 Asp Ser Gly Asp Pro Tyr Ala
 305                 310    



      <210> 810
      <211> 236
      <212> PRT
      <213> Homo sapiens


      <400> 810
 Met Ala Glu Thr Lys Leu Gln Leu Phe Val Lys Ala Ser Glu Asp Gly
   1               5                  10                  15    
 Glu Ser Val Gly His Cys Pro Ser Cys Gln Arg Leu Phe Met Val Leu
              20                  25                  30        
 Leu Leu Lys Gly Val Pro Phe Thr Leu Thr Thr Val Asp Thr Arg Arg
          35                  40                  45            
 Ser Pro Asp Val Leu Lys Asp Phe Ala Pro Gly Ser Gln Leu Pro Ile
      50                  55                  60                
 Leu Leu Tyr Asp Ser Asp Ala Lys Thr Asp Thr Leu Gln Ile Glu Asp
  65                  70                  75                  80
 Phe Leu Glu Glu Thr Leu Gly Pro Pro Asp Phe Pro Ser Leu Ala Pro
                  85                  90                  95    
 Arg Tyr Arg Glu Ser Asn Thr Ala Gly Asn Asp Val Phe His Lys Phe
             100                 105                 110        
 Ser Ala Phe Ile Lys Asn Pro Val Pro Ala Gln Asp Glu Ala Leu Tyr
         115                 120                 125            
 Gln Gln Leu Leu Arg Ala Leu Ala Arg Leu Asp Ser Tyr Leu Arg Ala
     130                 135                 140                
 Pro Leu Glu His Glu Leu Ala Gly Glu Pro Gln Leu Arg Glu Ser Arg
 145                 150                 155                 160
 Arg Arg Phe Leu Asp Gly Asp Arg Leu Thr Leu Ala Asp Cys Ser Leu
                 165                 170                 175    
 Leu Pro Lys Leu His Ile Val Asp Thr Val Cys Ala His Phe Arg Gln
             180                 185                 190        
 Ala Pro Ile Pro Ala Glu Leu Arg Gly Val Arg Arg Tyr Leu Asp Ser
         195                 200                 205            
 Ala Met Gln Glu Lys Glu Phe Lys Tyr Thr Cys Pro His Ser Ala Glu
     210                 215                 220                
 Ile Leu Ala Ala Tyr Arg Pro Ala Val His Pro Arg
 225                 230                 235    



      <210> 811
      <211> 498
      <212> PRT
      <213> Homo sapiens


      <400> 811
 Met Ser Leu Gly Pro Arg Pro Ala Pro Leu Ala Cys Pro Ser Arg Pro
   1               5                  10                  15    
 Arg Ala Leu Ala Pro Ser His Ala Trp Glu Ser Trp Pro Gly Thr Gly
              20                  25                  30        
 Pro Thr Ser Ser Ala Arg Ala Arg Gly Pro Ala Ala Gly Ser Cys Cys
          35                  40                  45            
 Lys Thr Phe Leu Gly Gly Ala Ala Arg Ala Pro Arg Ala Pro Gly Pro
      50                  55                  60                
 Asn Ala Arg Arg Val Gly Ser Pro Gly Pro Arg Gly Val Pro Gly Gly
  65                  70                  75                  80
 Lys Ser Ala Val Gly Ala Pro Arg Pro Arg Cys Pro Gly Ala Met Ala
                  85                  90                  95    
 Met Val Thr Gly Gly Trp Gly Gly Pro Gly Gly Asp Thr Asn Gly Val
             100                 105                 110        
 Asp Lys Ala Gly Gly Tyr Pro Arg Ala Ala Glu Asp Asp Ser Ala Ser
         115                 120                 125            
 Pro Pro Gly Ala Ala Ser Asp Ala Glu Pro Gly Asp Glu Glu Arg Pro
     130                 135                 140                
 Gly Leu Gln Val Asp Cys Val Val Cys Gly Asp Lys Ser Ser Gly Lys
 145                 150                 155                 160
 His Tyr Gly Val Phe Thr Cys Glu Gly Cys Lys Ser Phe Phe Lys Arg
                 165                 170                 175    
 Ser Ile Arg Arg Asn Leu Ser Tyr Thr Cys Arg Ser Asn Arg Asp Cys
             180                 185                 190        
 Gln Ile Asp Gln His His Arg Asn Gln Cys Gln Tyr Cys Arg Leu Lys
         195                 200                 205            
 Lys Cys Phe Arg Val Gly Met Arg Lys Glu Ala Val Gln Arg Gly Arg
     210                 215                 220                
 Ile Pro His Ser Leu Pro Gly Ala Val Ala Ala Ser Ser Gly Ser Pro
 225                 230                 235                 240
 Pro Gly Ser Ala Leu Ala Ala Val Ala Ser Gly Gly Asp Leu Phe Pro
                 245                 250                 255    
 Gly Gln Pro Val Ser Glu Leu Ile Ala Gln Leu Leu Arg Ala Glu Pro
             260                 265                 270        
 Tyr Pro Ala Ala Ala Gly Arg Phe Gly Ala Gly Gly Gly Ala Ala Gly
         275                 280                 285            
 Ala Val Leu Gly Ile Asp Asn Val Cys Glu Leu Ala Ala Arg Leu Leu
     290                 295                 300                
 Phe Ser Thr Val Glu Trp Ala Arg His Ala Pro Phe Phe Pro Glu Leu
 305                 310                 315                 320
 Pro Val Ala Asp Gln Val Ala Leu Leu Arg Leu Ser Trp Ser Glu Leu
                 325                 330                 335    
 Phe Val Leu Asn Ala Ala Gln Ala Ala Leu Pro Leu His Thr Ala Pro
             340                 345                 350        
 Leu Leu Ala Ala Ala Gly Leu His Ala Ala Pro Met Ala Ala Glu Arg
         355                 360                 365            
 Ala Val Ala Phe Met Asp Gln Val Arg Ala Phe Gln Glu Gln Val Asp
     370                 375                 380                
 Lys Leu Gly Arg Leu Gln Val Asp Ser Ala Glu Tyr Gly Cys Leu Lys
 385                 390                 395                 400
 Ala Ile Ala Leu Phe Thr Pro Asp Ala Cys Gly Leu Ser Asp Pro Ala
                 405                 410                 415    
 His Val Glu Ser Leu Gln Glu Lys Ala Gln Val Ala Leu Thr Glu Tyr
             420                 425                 430        
 Val Arg Ala Gln Tyr Pro Ser Gln Pro Gln Arg Phe Gly Arg Leu Leu
         435                 440                 445            
 Leu Arg Leu Pro Ala Leu Arg Ala Val Pro Ala Ser Leu Ile Ser Gln
     450                 455                 460                
 Leu Phe Phe Met Arg Leu Val Gly Lys Thr Pro Ile Glu Thr Leu Ile
 465                 470                 475                 480
 Arg Asp Met Leu Leu Ser Gly Ser Thr Phe Asn Trp Pro Tyr Gly Ser
                 485                 490                 495    
 Gly Gln
        



      <210> 812
      <211> 172
      <212> PRT
      <213> Homo sapiens


      <400> 812
 Met Ser Arg Met Met Lys Ala Ser Gln Gly Ala Leu Leu Gly Asp Lys
   1               5                  10                  15    
 Ser Pro Glu Phe Ser Lys Lys Cys Ser Glu Arg Trp Lys Thr Met Ser
              20                  25                  30        
 Gly Lys Glu Lys Ser Lys Phe Asp Glu Met Ala Lys Thr Asp Lys Val
          35                  40                  45            
 His Cys Asp Arg Glu Met Lys Gly Pro Ala Lys Gly Gly Lys Lys Lys
      50                  55                  60                
 Lys Asp Pro Ser Ala Pro Lys Arg Pro Pro Ser Gly Phe Phe Leu Phe
  65                  70                  75                  80
 Ser Ser Glu Ile Arg Pro Lys Ile Lys Ser Thr Asn Pro Gly Ile Ser
                  85                  90                  95    
 Ile Gly Asp Val Ala Lys Lys Leu Gly Glu Met Trp Asn Asn Leu Asn
             100                 105                 110        
 Asp Ser Glu Lys Gln Pro Tyr Ile Thr Lys Thr Ala Lys Leu Lys Glu
         115                 120                 125            
 Lys Tyr Glu Lys Asp Val Ala Asp Ser Lys Ser Lys Gly Lys Phe Asp
     130                 135                 140                
 Gly Ser Lys Arg Pro Ala Lys Val Ala Trp Lys Lys Val Glu Glu Glu
 145                 150                 155                 160
 Asp Glu Asp Glu Glu Glu Asp Glu Glu Glu Asp Glu
                 165                 170        



      <210> 813
      <211> 1709
      <212> PRT
      <213> Homo sapiens


      <400> 813
 Met Asp Ala Asp Ser Ala Ser Ser Ser Glu Ser Glu Arg Asn Ile Thr
   1               5                  10                  15    
 Ile Met Ala Ser Gly Asn Thr Gly Gly Glu Lys Asp Gly Leu Arg Asn
              20                  25                  30        
 Ser Thr Gly Leu Gly Ser Gln Asn Lys Phe Val Val Gly Ser Ser Ser
          35                  40                  45            
 Asn Asn Val Gly His Gly Ser Ser Thr Gly Pro Trp Gly Phe Ser His
      50                  55                  60                
 Gly Ala Ile Ile Ser Thr Cys Gln Val Ser Val Asp Ala Pro Glu Ser
  65                  70                  75                  80
 Lys Ser Glu Ser Ser Asn Asn Arg Met Asn Ala Trp Gly Thr Val Ser
                  85                  90                  95    
 Ser Ser Ser Asn Gly Gly Leu Asn Pro Ser Thr Leu Asn Ser Ala Ser
             100                 105                 110        
 Asn His Gly Ala Trp Pro Val Leu Glu Asn Asn Gly Leu Ala Leu Lys
         115                 120                 125            
 Gly Pro Val Gly Ser Gly Ser Ser Gly Ile Asn Ile Gln Cys Ser Thr
     130                 135                 140                
 Ile Gly Gln Met Pro Asn Asn Gln Ser Ile Asn Ser Lys Val Ser Gly
 145                 150                 155                 160
 Gly Ser Thr His Gly Thr Trp Gly Ser Leu Gln Glu Thr Cys Glu Ser
                 165                 170                 175    
 Glu Val Ser Gly Thr Gln Lys Val Ser Phe Ser Gly Gln Pro Gln Asn
             180                 185                 190        
 Ile Thr Thr Glu Met Thr Gly Pro Asn Asn Thr Thr Asn Phe Met Thr
         195                 200                 205            
 Ser Ser Leu Pro Asn Ser Gly Ser Val Gln Asn Asn Glu Leu Pro Ser
     210                 215                 220                
 Ser Asn Thr Gly Ala Trp Arg Val Ser Thr Met Asn His Pro Gln Met
 225                 230                 235                 240
 Gln Ala Pro Ser Gly Met Asn Gly Thr Ser Leu Ser His Leu Ser Asn
                 245                 250                 255    
 Gly Glu Ser Lys Ser Gly Gly Ser Tyr Gly Thr Thr Trp Gly Ala Tyr
             260                 265                 270        
 Gly Ser Asn Tyr Ser Gly Asp Lys Cys Ser Gly Pro Asn Gly Gln Ala
         275                 280                 285            
 Asn Gly Asp Thr Val Asn Ala Thr Leu Met Gln Pro Gly Val Asn Gly
     290                 295                 300                
 Pro Met Gly Thr Asn Phe Gln Val Asn Thr Asn Lys Gly Gly Gly Val
 305                 310                 315                 320
 Trp Glu Ser Gly Ala Ala Asn Ser Gln Ser Thr Ser Trp Gly Ser Gly
                 325                 330                 335    
 Asn Gly Ala Asn Ser Gly Gly Ser Arg Arg Gly Trp Gly Thr Pro Ala
             340                 345                 350        
 Gln Asn Thr Gly Thr Asn Leu Pro Ser Val Glu Trp Asn Lys Leu Pro
         355                 360                 365            
 Ser Asn Gln His Ser Asn Asp Ser Ala Asn Gly Asn Gly Lys Thr Phe
     370                 375                 380                
 Thr Asn Gly Trp Lys Ser Thr Glu Glu Glu Asp Gln Gly Ser Ala Thr
 385                 390                 395                 400
 Ser Gln Thr Asn Glu Gln Ser Ser Val Trp Ala Lys Thr Gly Gly Thr
                 405                 410                 415    
 Val Glu Ser Asp Gly Ser Thr Glu Ser Thr Gly Arg Leu Glu Glu Lys
             420                 425                 430        
 Gly Thr Gly Glu Ser Gln Ser Arg Asp Arg Arg Lys Ile Asp Gln His
         435                 440                 445            
 Thr Leu Leu Gln Ser Ile Val Asn Arg Thr Asp Leu Asp Pro Arg Val
     450                 455                 460                
 Leu Ser Asn Ser Gly Trp Gly Gln Thr Pro Ile Lys Gln Asn Thr Ala
 465                 470                 475                 480
 Trp Asp Thr Glu Thr Ser Pro Arg Gly Glu Arg Lys Thr Asp Asn Gly
                 485                 490                 495    
 Thr Glu Ala Trp Gly Ser Ser Ala Thr Gln Thr Phe Asn Ser Gly Ala
             500                 505                 510        
 Cys Ile Asp Lys Thr Ser Pro Asn Gly Asn Asp Thr Ser Ser Val Ser
         515                 520                 525            
 Gly Trp Gly Asp Pro Lys Pro Ala Leu Arg Trp Gly Asp Ser Lys Gly
     530                 535                 540                
 Ser Asn Cys Gln Gly Gly Trp Glu Asp Asp Ser Ala Ala Thr Gly Met
 545                 550                 555                 560
 Val Lys Ser Asn Gln Trp Gly Asn Cys Lys Glu Glu Lys Ala Ala Trp
                 565                 570                 575    
 Asn Asp Ser Gln Lys Asn Lys Gln Gly Trp Gly Asp Gly Gln Lys Ser
             580                 585                 590        
 Ser Gln Gly Trp Ser Val Ser Ala Ser Asp Asn Trp Gly Glu Thr Ser
         595                 600                 605            
 Arg Asn Asn His Trp Gly Glu Ala Asn Lys Lys Ser Ser Ser Gly Gly
     610                 615                 620                
 Ser Asp Ser Asp Arg Ser Val Ser Gly Trp Asn Glu Leu Gly Lys Thr
 625                 630                 635                 640
 Ser Ser Phe Thr Trp Gly Asn Asn Ile Asn Pro Asn Asn Ser Ser Gly
                 645                 650                 655    
 Trp Asp Glu Ser Ser Lys Pro Thr Pro Ser Gln Gly Trp Gly Asp Pro
             660                 665                 670        
 Pro Lys Ser Asn Gln Ser Leu Gly Trp Gly Asp Ser Ser Lys Pro Val
         675                 680                 685            
 Ser Ser Pro Asp Trp Asn Lys Gln Gln Asp Ile Val Gly Ser Trp Gly
     690                 695                 700                
 Ile Pro Pro Ala Thr Gly Lys Pro Pro Gly Thr Gly Trp Leu Gly Gly
 705                 710                 715                 720
 Pro Ile Pro Ala Pro Ala Lys Glu Glu Glu Pro Thr Gly Trp Glu Glu
                 725                 730                 735    
 Pro Ser Pro Glu Ser Ile Arg Arg Lys Met Glu Ile Asp Asp Gly Thr
             740                 745                 750        
 Ser Ala Trp Gly Asp Pro Ser Lys Tyr Asn Tyr Lys Asn Val Asn Met
         755                 760                 765            
 Trp Asn Lys Asn Val Pro Asn Gly Asn Ser Arg Ser Asp Gln Gln Ala
     770                 775                 780                
 Gln Val His Gln Leu Leu Thr Pro Ala Ser Ala Ile Ser Asn Lys Glu
 785                 790                 795                 800
 Ala Ser Ser Gly Ser Gly Trp Gly Glu Pro Trp Gly Glu Pro Ser Thr
                 805                 810                 815    
 Pro Ala Thr Thr Val Asp Asn Gly Thr Ser Ala Trp Gly Lys Pro Ile
             820                 825                 830        
 Asp Ser Gly Pro Ser Trp Gly Glu Pro Ile Ala Ala Ala Ser Ser Thr
         835                 840                 845            
 Ser Thr Trp Gly Ser Ser Ser Val Gly Pro Gln Ala Leu Ser Lys Ser
     850                 855                 860                
 Gly Pro Lys Ser Met Gln Asp Gly Trp Cys Gly Asp Asp Met Pro Leu
 865                 870                 875                 880
 Pro Gly Asn Arg Pro Thr Gly Trp Glu Glu Glu Glu Asp Val Glu Ile
                 885                 890                 895    
 Gly Met Trp Asn Ser Asn Ser Ser Gln Glu Leu Asn Ser Ser Leu Asn
             900                 905                 910        
 Trp Pro Pro Tyr Thr Lys Lys Met Ser Ser Lys Gly Leu Ser Gly Lys
         915                 920                 925            
 Lys Arg Arg Arg Glu Arg Gly Met Met Lys Gly Gly Asn Lys Gln Glu
     930                 935                 940                
 Glu Ala Trp Ile Asn Pro Phe Val Lys Gln Phe Ser Asn Ile Ser Phe
 945                 950                 955                 960
 Ser Arg Asp Ser Pro Glu Glu Asn Val Gln Ser Asn Lys Met Asp Leu
                 965                 970                 975    
 Ser Gly Gly Met Leu Gln Asp Lys Arg Met Glu Ile Asp Lys His Ser
             980                 985                 990        
 Leu Asn Ile Gly Asp Tyr Asn Arg Thr Val Gly Lys Gly Pro Gly Ser
         995                1000                1005            
 Arg Pro Gln Ile Ser Lys Glu Ser Ser Met Glu Arg Asn Pro Tyr Phe
    1010                1015                1020                
 Asp Lys Asp Gly Ile Val Ala Asp Glu Ser Gln Asn Met Gln Phe Met
1025                1030                1035                1040
 Ser Ser Gln Ser Met Lys Leu Pro Pro Ser Asn Ser Ala Leu Pro Asn
                1045                1050                1055    
 Gln Ala Leu Gly Ser Ile Ala Gly Leu Gly Met Gln Asn Leu Asn Ser
            1060                1065                1070        
 Val Arg Gln Asn Gly Asn Pro Ser Met Phe Gly Val Gly Asn Thr Ala
        1075                1080                1085            
 Ala Gln Pro Arg Gly Met Gln Gln Pro Pro Ala Gln Pro Leu Ser Ser
    1090                1095                1100                
 Ser Gln Pro Asn Leu Arg Ala Gln Val Pro Pro Pro Leu Leu Ser Pro
1105                1110                1115                1120
 Gln Val Pro Val Ser Leu Leu Lys Tyr Ala Pro Asn Asn Gly Gly Leu
                1125                1130                1135    
 Asn Pro Leu Phe Gly Pro Gln Gln Val Ala Met Leu Asn Gln Leu Ser
            1140                1145                1150        
 Gln Leu Asn Gln Leu Ser Gln Ile Ser Gln Leu Gln Arg Leu Leu Ala
        1155                1160                1165            
 Gln Gln Gln Arg Ala Gln Ser Gln Arg Ser Val Pro Ser Gly Asn Arg
    1170                1175                1180                
 Pro Gln Gln Asp Gln Gln Gly Arg Pro Leu Ser Val Gln Gln Gln Met
1185                1190                1195                1200
 Met Gln Gln Ser Arg Gln Leu Asp Pro Asn Leu Leu Val Lys Gln Gln
                1205                1210                1215    
 Thr Pro Pro Ser Gln Gln Gln Pro Leu His Gln Pro Ala Met Lys Ser
            1220                1225                1230        
 Phe Leu Asp Asn Val Met Pro His Thr Thr Pro Glu Leu Gln Lys Gly
        1235                1240                1245            
 Pro Ser Pro Ile Asn Ala Phe Ser Asn Phe Pro Ile Gly Leu Asn Ser
    1250                1255                1260                
 Asn Leu Asn Val Asn Met Asp Met Asn Ser Ile Lys Glu Pro Gln Ser
1265                1270                1275                1280
 Arg Leu Arg Lys Trp Thr Thr Val Asp Ser Ile Ser Val Asn Thr Ser
                1285                1290                1295    
 Leu Asp Gln Asn Ser Ser Lys His Gly Ala Ile Ser Ser Gly Phe Arg
            1300                1305                1310        
 Leu Glu Glu Ser Pro Phe Val Pro Tyr Asp Phe Met Asn Ser Ser Thr
        1315                1320                1325            
 Ser Pro Ala Ser Pro Pro Gly Ser Ile Gly Asp Gly Trp Pro Arg Ala
    1330                1335                1340                
 Lys Ser Pro Asn Gly Ser Ser Ser Val Asn Trp Pro Pro Glu Phe Arg
1345                1350                1355                1360
 Pro Gly Glu Pro Trp Lys Gly Tyr Pro Asn Ile Asp Pro Glu Thr Asp
                1365                1370                1375    
 Pro Tyr Val Thr Pro Gly Ser Val Ile Asn Asn Leu Ser Ile Asn Thr
            1380                1385                1390        
 Val Arg Glu Val Asp His Leu Arg Asp Arg Asn Ser Gly Ser Ser Ser
        1395                1400                1405            
 Ser Leu Asn Thr Thr Leu Pro Ser Thr Ser Ala Trp Ser Ser Ile Arg
    1410                1415                1420                
 Ala Ser Asn Tyr Asn Val Pro Leu Ser Ser Thr Ala Gln Ser Thr Ser
1425                1430                1435                1440
 Ala Arg Asn Ser Asp Ser Lys Leu Thr Trp Ser Pro Gly Ser Val Thr
                1445                1450                1455    
 Asn Thr Ser Leu Ala His Glu Leu Trp Lys Val Pro Leu Pro Pro Lys
            1460                1465                1470        
 Asn Ile Thr Ala Pro Ser Arg Pro Pro Pro Gly Leu Thr Gly Gln Lys
        1475                1480                1485            
 Pro Pro Leu Ser Thr Trp Asp Asn Ser Pro Leu Arg Ile Gly Gly Gly
    1490                1495                1500                
 Trp Gly Asn Ser Asp Ala Arg Tyr Thr Pro Gly Ser Ser Trp Gly Glu
1505                1510                1515                1520
 Ser Ser Ser Gly Arg Ile Thr Asn Trp Leu Val Leu Lys Asn Leu Thr
                1525                1530                1535    
 Pro Gln Ile Asp Gly Ser Thr Leu Arg Thr Leu Cys Met Gln His Gly
            1540                1545                1550        
 Pro Leu Ile Thr Phe His Leu Asn Leu Pro His Gly Asn Ala Leu Val
        1555                1560                1565            
 Arg Tyr Ser Ser Lys Glu Glu Val Val Lys Ala Gln Lys Ser Leu His
    1570                1575                1580                
 Met Cys Val Leu Gly Asn Thr Thr Ile Leu Ala Glu Phe Ala Ser Glu
1585                1590                1595                1600
 Glu Glu Ile Ser Arg Phe Phe Ala Gln Ser Gln Ser Leu Thr Pro Ser
                1605                1610                1615    
 Pro Gly Trp Gln Ser Leu Gly Ser Ser Gln Ser Arg Leu Gly Ser Leu
            1620                1625                1630        
 Asp Cys Ser His Ser Phe Ser Ser Arg Thr Asp Leu Asn His Trp Asn
        1635                1640                1645            
 Gly Ala Gly Leu Ser Gly Thr Asn Cys Gly Asp Leu His Gly Thr Ser
    1650                1655                1660                
 Leu Trp Gly Thr Pro His Tyr Ser Thr Ser Leu Trp Gly Pro Pro Ser
1665                1670                1675                1680
 Ser Ser Asp Pro Arg Gly Ile Ser Ser Pro Ser Pro Ile Asn Ala Phe
                1685                1690                1695    
 Leu Ser Val Asp His Leu Gly Gly Gly Gly Glu Ser Met
            1700                1705                



      <210> 814
      <211> 725
      <212> PRT
      <213> Homo sapiens


      <400> 814
 Met Met Lys Gly Gly Asn Lys Gln Glu Glu Ala Trp Ile Asn Pro Phe
   1               5                  10                  15    
 Val Lys Gln Phe Ser Asn Ile Ser Phe Ser Arg Asp Ser Pro Glu Glu
              20                  25                  30        
 Asn Val Gln Ser Asn Lys Met Asp Leu Ser Gly Gly Met Leu Gln Asp
          35                  40                  45            
 Lys Arg Met Glu Ile Asp Lys His Ser Leu Asn Ile Gly Asp Tyr Asn
      50                  55                  60                
 Arg Thr Val Gly Lys Gly Pro Gly Ser Arg Pro Gln Ile Ser Lys Glu
  65                  70                  75                  80
 Ser Ser Met Glu Arg Asn Pro Tyr Phe Asp Lys Asn Gly Asn Pro Ser
                  85                  90                  95    
 Met Phe Gly Val Gly Asn Thr Ala Ala Gln Pro Arg Gly Met Gln Gln
             100                 105                 110        
 Pro Pro Ala Gln Pro Leu Ser Ser Ser Gln Pro Asn Leu Arg Ala Gln
         115                 120                 125            
 Val Pro Pro Pro Leu Leu Ser Pro Gln Val Pro Val Ser Leu Leu Lys
     130                 135                 140                
 Tyr Ala Pro Asn Asn Gly Gly Leu Asn Pro Leu Phe Gly Pro Gln Gln
 145                 150                 155                 160
 Val Ala Met Leu Asn Gln Leu Ser Gln Leu Asn Gln Leu Ser Gln Ile
                 165                 170                 175    
 Ser Gln Leu Gln Arg Leu Leu Ala Gln Gln Gln Arg Ala Gln Ser Gln
             180                 185                 190        
 Arg Ser Val Pro Ser Gly Asn Arg Pro Gln Gln Asp Gln Gln Gly Arg
         195                 200                 205            
 Pro Leu Ser Val Gln Gln Gln Met Met Gln Gln Ser Arg Gln Leu Asp
     210                 215                 220                
 Pro Asn Leu Leu Val Lys Gln Gln Thr Pro Pro Ser Gln Gln Gln Pro
 225                 230                 235                 240
 Leu His Gln Pro Ala Met Lys Ser Phe Leu Asp Asn Val Met Pro His
                 245                 250                 255    
 Thr Thr Pro Glu Leu Gln Lys Gly Pro Ser Pro Ile Asn Ala Phe Ser
             260                 265                 270        
 Asn Phe Pro Ile Gly Leu Asn Ser Asn Leu Asn Val Asn Met Asp Met
         275                 280                 285            
 Asn Ser Ile Lys Glu Pro Gln Ser Arg Leu Arg Lys Trp Thr Thr Val
     290                 295                 300                
 Asp Ser Ile Ser Val Asn Thr Ser Leu Asp Gln Asn Ser Ser Lys His
 305                 310                 315                 320
 Gly Ala Ile Ser Ser Gly Phe Arg Leu Glu Glu Ser Pro Phe Val Pro
                 325                 330                 335    
 Tyr Asp Phe Met Asn Ser Ser Thr Ser Pro Ala Ser Pro Pro Gly Ser
             340                 345                 350        
 Ile Gly Asp Gly Trp Pro Arg Ala Lys Ser Pro Asn Gly Ser Ser Ser
         355                 360                 365            
 Val Asn Trp Pro Pro Glu Phe Arg Pro Gly Glu Pro Trp Lys Gly Tyr
     370                 375                 380                
 Pro Asn Ile Asp Pro Glu Thr Asp Pro Tyr Val Thr Pro Gly Ser Val
 385                 390                 395                 400
 Ile Asn Asn Leu Ser Ile Asn Thr Val Arg Glu Val Asp His Leu Arg
                 405                 410                 415    
 Asp Arg Asn Ser Gly Ser Ser Ser Ser Leu Asn Thr Thr Leu Pro Ser
             420                 425                 430        
 Thr Ser Ala Trp Ser Ser Ile Arg Ala Ser Asn Tyr Asn Val Pro Leu
         435                 440                 445            
 Ser Ser Thr Ala Gln Ser Thr Ser Ala Arg Asn Ser Asp Ser Lys Leu
     450                 455                 460                
 Thr Trp Ser Pro Gly Ser Val Thr Asn Thr Ser Leu Ala His Glu Leu
 465                 470                 475                 480
 Trp Lys Val Pro Leu Pro Pro Lys Asn Ile Thr Ala Pro Ser Arg Pro
                 485                 490                 495    
 Pro Pro Gly Leu Thr Gly Gln Lys Pro Pro Leu Ser Thr Trp Asp Asn
             500                 505                 510        
 Ser Pro Leu Arg Ile Gly Gly Gly Trp Gly Asn Ser Asp Ala Arg Tyr
         515                 520                 525            
 Thr Pro Gly Ser Ser Trp Gly Glu Ser Ser Ser Gly Arg Ile Thr Asn
     530                 535                 540                
 Trp Leu Val Leu Lys Asn Leu Thr Pro Gln Ile Asp Gly Ser Thr Leu
 545                 550                 555                 560
 Arg Thr Leu Cys Met Gln His Gly Pro Leu Ile Thr Phe His Leu Asn
                 565                 570                 575    
 Leu Pro His Gly Asn Ala Leu Val Arg Tyr Ser Ser Lys Glu Glu Val
             580                 585                 590        
 Val Lys Ala Gln Lys Ser Leu His Met Cys Val Leu Gly Asn Thr Thr
         595                 600                 605            
 Ile Leu Ala Glu Phe Ala Ser Glu Glu Glu Ile Ser Arg Phe Phe Ala
     610                 615                 620                
 Gln Ser Gln Ser Leu Thr Pro Ser Pro Gly Trp Gln Ser Leu Gly Ser
 625                 630                 635                 640
 Ser Gln Ser Arg Leu Gly Ser Leu Asp Cys Ser His Ser Phe Ser Ser
                 645                 650                 655    
 Arg Thr Asp Leu Asn His Trp Asn Gly Ala Gly Leu Ser Gly Thr Asn
             660                 665                 670        
 Cys Gly Asp Leu His Gly Thr Ser Leu Trp Gly Thr Pro His Tyr Ser
         675                 680                 685            
 Thr Ser Leu Trp Gly Pro Pro Ser Ser Ser Asp Pro Arg Gly Ile Ser
     690                 695                 700                
 Ser Pro Ser Pro Ile Asn Ala Phe Leu Ser Val Asp His Leu Gly Gly
 705                 710                 715                 720
 Gly Gly Glu Ser Met
                 725



      <210> 815
      <211> 650
      <212> PRT
      <213> Homo sapiens


      <400> 815
 Met Gln Phe Met Ser Ser Gln Ser Met Lys Leu Pro Pro Ser Asn Ser
   1               5                  10                  15    
 Ala Leu Pro Asn Gln Ala Leu Gly Ser Ile Ala Gly Leu Gly Met Gln
              20                  25                  30        
 Asn Leu Asn Ser Val Arg Gln Asn Gly Asn Pro Ser Met Phe Gly Val
          35                  40                  45            
 Gly Asn Thr Ala Ala Gln Pro Arg Gly Met Gln Gln Pro Pro Ala Gln
      50                  55                  60                
 Pro Leu Ser Ser Ser Gln Pro Asn Leu Arg Ala Gln Val Pro Pro Pro
  65                  70                  75                  80
 Leu Leu Ser Pro Gln Val Ala Met Leu Asn Gln Leu Ser Gln Leu Asn
                  85                  90                  95    
 Gln Leu Ser Gln Ile Ser Gln Leu Gln Arg Leu Leu Ala Gln Gln Gln
             100                 105                 110        
 Arg Ala Gln Ser Gln Arg Ser Val Pro Ser Gly Asn Arg Pro Gln Gln
         115                 120                 125            
 Asp Gln Gln Gly Arg Pro Leu Ser Val Gln Gln Gln Met Met Gln Gln
     130                 135                 140                
 Ser Arg Gln Leu Asp Pro Asn Leu Leu Val Lys Gln Gln Thr Pro Pro
 145                 150                 155                 160
 Ser Gln Gln Gln Pro Leu His Gln Pro Ala Met Lys Ser Phe Leu Asp
                 165                 170                 175    
 Asn Val Met Pro His Thr Thr Pro Glu Leu Gln Lys Gly Pro Ser Pro
             180                 185                 190        
 Ile Asn Ala Phe Ser Asn Phe Pro Ile Gly Leu Asn Ser Asn Leu Asn
         195                 200                 205            
 Val Asn Met Asp Met Asn Ser Ile Lys Glu Pro Gln Ser Arg Leu Arg
     210                 215                 220                
 Lys Trp Thr Thr Val Asp Ser Ile Ser Val Asn Thr Ser Leu Asp Gln
 225                 230                 235                 240
 Asn Ser Ser Lys His Gly Ala Ile Ser Ser Gly Phe Arg Leu Glu Glu
                 245                 250                 255    
 Ser Pro Phe Val Pro Tyr Asp Phe Met Asn Ser Ser Thr Ser Pro Ala
             260                 265                 270        
 Ser Pro Pro Gly Ser Ile Gly Asp Gly Trp Pro Arg Ala Lys Ser Pro
         275                 280                 285            
 Asn Gly Ser Ser Ser Val Asn Trp Pro Pro Glu Phe Arg Pro Gly Glu
     290                 295                 300                
 Pro Trp Lys Gly Tyr Pro Asn Ile Asp Pro Glu Thr Asp Pro Tyr Val
 305                 310                 315                 320
 Thr Pro Gly Ser Val Ile Asn Asn Leu Ser Ile Asn Thr Val Arg Glu
                 325                 330                 335    
 Val Asp His Leu Arg Asp Arg Asn Ser Gly Ser Ser Ser Ser Leu Asn
             340                 345                 350        
 Thr Thr Leu Pro Ser Thr Ser Ala Trp Ser Ser Ile Arg Ala Ser Asn
         355                 360                 365            
 Tyr Asn Val Pro Leu Ser Ser Thr Ala Gln Ser Thr Ser Ala Arg Asn
     370                 375                 380                
 Ser Asp Ser Lys Leu Thr Trp Ser Pro Gly Ser Val Thr Asn Thr Ser
 385                 390                 395                 400
 Leu Ala His Glu Leu Trp Lys Val Pro Leu Pro Pro Lys Asn Ile Thr
                 405                 410                 415    
 Ala Pro Ser Arg Pro Pro Pro Gly Leu Thr Gly Gln Lys Pro Pro Leu
             420                 425                 430        
 Ser Thr Trp Asp Asn Ser Pro Leu Arg Ile Gly Gly Gly Trp Gly Asn
         435                 440                 445            
 Ser Asp Ala Arg Tyr Thr Pro Gly Ser Ser Trp Gly Glu Ser Ser Ser
     450                 455                 460                
 Gly Arg Ile Thr Asn Trp Leu Val Leu Lys Asn Leu Thr Pro Gln Ile
 465                 470                 475                 480
 Asp Gly Ser Thr Leu Arg Thr Leu Cys Met Gln His Gly Pro Leu Ile
                 485                 490                 495    
 Thr Phe His Leu Asn Leu Pro His Gly Asn Ala Leu Val Arg Tyr Ser
             500                 505                 510        
 Ser Lys Glu Glu Val Val Lys Ala Gln Lys Ser Leu His Met Cys Val
         515                 520                 525            
 Leu Gly Asn Thr Thr Ile Leu Ala Glu Phe Ala Ser Glu Glu Glu Ile
     530                 535                 540                
 Ser Arg Phe Phe Ala Gln Ser Gln Ser Leu Thr Pro Ser Pro Gly Trp
 545                 550                 555                 560
 Gln Ser Leu Gly Ser Ser Gln Ser Arg Leu Gly Ser Leu Asp Cys Ser
                 565                 570                 575    
 His Ser Phe Ser Ser Arg Thr Asp Leu Asn His Trp Asn Gly Ala Gly
             580                 585                 590        
 Leu Ser Gly Thr Asn Cys Gly Asp Leu His Gly Thr Ser Leu Trp Gly
         595                 600                 605            
 Thr Pro His Tyr Ser Thr Ser Leu Trp Gly Pro Pro Ser Ser Ser Asp
     610                 615                 620                
 Pro Arg Gly Ile Ser Ser Pro Ser Pro Ile Asn Ala Phe Leu Ser Val
 625                 630                 635                 640
 Asp His Leu Gly Gly Gly Gly Glu Ser Met
                 645                 650



      <210> 816
      <211> 219
      <212> PRT
      <213> Homo sapiens


      <400> 816
 Met Glu Ala Ser Trp Arg Gln Val Ala Gly Gly Arg Gly Arg Ser Arg
   1               5                  10                  15    
 Gly Arg Ala Thr Ala Ala Pro Ser Gly Asn Gly Val His Leu Arg Gly
              20                  25                  30        
 Ala Gly Gly Gly Arg Glu Lys Gly Ser Val Gly Ala Val Pro Ser Gly
          35                  40                  45            
 Thr Ser Pro Gly Gly Val Ala Thr Thr Ala Ala Ala Gly Ser Arg His
      50                  55                  60                
 Ser Pro Ala Gly Ser Gln Ala Leu Gln Thr Thr Ala Ala Ser Glu Leu
  65                  70                  75                  80
 Met Ser Gln Lys Lys Phe Glu Glu Ile Lys Lys Ala Asn Gln Ala Ala
                  85                  90                  95    
 Ala Arg Lys Leu Val Glu Glu Gln Phe Ser Ser Ser Ser Glu Glu Gly
             100                 105                 110        
 Asp Glu Asp Phe Glu Gly Lys Gln Gly Lys Ile Leu Ala Asn Thr Phe
         115                 120                 125            
 Ile Thr Tyr Thr Thr Gln Thr Asp Gly Asp Thr Arg Glu Leu Glu Arg
     130                 135                 140                
 Thr Lys Gln Tyr Val Asn Glu Ala Phe Gln Ala Gly Ala Met Thr Cys
 145                 150                 155                 160
 Leu Ile Cys Ile Ala Ser Val Lys Arg Asn Gln Ala Val Trp Ser Cys
                 165                 170                 175    
 Ser Gly Cys Phe Cys Ile Phe His Met Pro Cys Ile Gln Lys Trp Ala
             180                 185                 190        
 Lys Asp Thr Gln Phe Leu Val Ser Ser Val Thr Asp Asp Asp Ser Gly
         195                 200                 205            
 Lys Lys Asp Cys Pro Trp Pro Cys Pro Lys Met
     210                 215                



      <210> 817
      <211> 351
      <212> PRT
      <213> Homo sapiens


      <400> 817
 Met Glu Asp Ser Gln Glu Thr Ser Pro Ser Ser Asn Asn Ser Ser Glu
   1               5                  10                  15    
 Glu Leu Ser Ser Ala Leu His Leu Ser Lys Gly Met Ser Ile Phe Leu
              20                  25                  30        
 Asp Ile Leu Arg Arg Ala Asp Lys Asn Asp Asp Gly Lys Leu Ser Phe
          35                  40                  45            
 Glu Glu Phe Lys Ala Tyr Phe Ala Asp Gly Val Leu Ser Gly Glu Glu
      50                  55                  60                
 Leu His Glu Leu Phe His Thr Ile Asp Thr His Asn Thr Asn Asn Leu
  65                  70                  75                  80
 Asp Thr Glu Glu Leu Cys Glu Tyr Phe Ser Gln His Leu Gly Glu Tyr
                  85                  90                  95    
 Glu Asn Val Leu Ala Ala Leu Glu Asp Leu Asn Leu Ser Ile Leu Lys
             100                 105                 110        
 Ala Met Gly Lys Thr Lys Lys Asp Tyr Gln Glu Ala Ser Asn Leu Glu
         115                 120                 125            
 Gln Phe Val Thr Arg Phe Leu Leu Lys Glu Thr Leu Asn Gln Leu Gln
     130                 135                 140                
 Ser Leu Gln Asn Ser Leu Glu Cys Ala Met Glu Thr Thr Glu Glu Gln
 145                 150                 155                 160
 Thr Arg Gln Glu Arg Gln Gly Pro Ala Lys Pro Glu Val Leu Ser Ile
                 165                 170                 175    
 Gln Trp Pro Gly Lys Arg Ser Ser Arg Arg Val Gln Arg His Asn Ser
             180                 185                 190        
 Phe Ser Pro Asn Ser Pro Gln Phe Asn Val Ser Gly Pro Gly Leu Leu
         195                 200                 205            
 Glu Glu Asp Asn Gln Trp Met Thr Gln Ile Asn Arg Leu Gln Lys Leu
     210                 215                 220                
 Ile Asp Arg Leu Glu Lys Lys Asp Leu Lys Leu Glu Pro Pro Glu Glu
 225                 230                 235                 240
 Glu Ile Ile Glu Gly Asn Thr Lys Ser His Ile Met Leu Val Gln Arg
                 245                 250                 255    
 Gln Met Ser Val Ile Glu Glu Asp Leu Glu Glu Phe Gln Leu Ala Leu
             260                 265                 270        
 Lys His Tyr Val Glu Ser Ala Ser Ser Gln Ser Gly Cys Leu Arg Ile
         275                 280                 285            
 Ser Ile Gln Lys Leu Ser Asn Glu Ser Arg Tyr Met Ile Tyr Glu Phe
     290                 295                 300                
 Trp Glu Asn Ser Ser Val Trp Asn Ser His Leu Gln Thr Asn Tyr Ser
 305                 310                 315                 320
 Lys Thr Phe Gln Arg Ser Asn Val Asp Phe Leu Glu Thr Pro Glu Leu
                 325                 330                 335    
 Thr Ser Thr Met Leu Val Pro Ala Ser Trp Trp Ile Leu Asn Asn
             340                 345                 350    



      <210> 818
      <211> 123
      <212> PRT
      <213> Homo sapiens


      <400> 818
 Met Glu Gly Leu Val Val Ala Ala Gly Gly Asp Val Ser Leu His Asn
   1               5                  10                  15    
 Phe Ser Ala Arg Leu Trp Glu Gln Leu Val His Phe His Val Met Arg
              20                  25                  30        
 Leu Thr Asp Ser Leu Phe Leu Trp Val Gly Ala Thr Pro His Leu Arg
          35                  40                  45            
 Asn Leu Ala Val Ala Met Cys Ser Arg Tyr Asp Ser Ile Pro Val Ser
      50                  55                  60                
 Thr Ser Leu Leu Gly Asp Thr Ser Asp Thr Thr Ser Thr Gly Leu Ala
  65                  70                  75                  80
 Gln Arg Leu Ala Arg Lys Thr Asn Lys Gln Val Phe Val Ser Tyr Asn
                  85                  90                  95    
 Leu Gln Asn Thr Asp Ser Asn Phe Ala Leu Leu Val Glu Asn Arg Ile
             100                 105                 110        
 Lys Glu Glu Met Glu Ala Phe Pro Glu Lys Phe
         115                 120            



      <210> 819
      <211> 105
      <212> PRT
      <213> Homo sapiens


      <400> 819
 Met Ala Leu Arg Tyr Pro Met Ala Met Gly Leu Asn Lys Gly His Lys
   1               5                  10                  15    
 Val Thr Lys Asn Val Ser Lys Pro Arg His Ser Arg Cys Ser Gly Cys
              20                  25                  30        
 Leu Thr Lys Tyr Thr Glu Phe Val Arg Asp Met Ile Arg Glu Val Cys
          35                  40                  45            
 Gly Phe Ala Leu Tyr Lys Gln His Ala Met Glu Leu Leu Lys Val Ser
      50                  55                  60                
 Lys Asp Lys Gln Ala Leu Lys Phe Ile Lys Lys Arg Val Gly Thr His
  65                  70                  75                  80
 Ile His Thr Lys Arg Lys Arg Glu Glu Leu Ser Asn Val Leu Ala Ile
                  85                  90                  95    
 Thr Arg Lys Val Ala Ala Met Lys Asp
             100                 105



      <210> 820
      <211> 585
      <212> PRT
      <213> Homo sapiens


      <400> 820
 Met Pro Ala Leu Ser Thr Gly Ser Gly Ser Asp Thr Gly Leu Tyr Glu
   1               5                  10                  15    
 Leu Leu Ala Ala Leu Pro Ala Gln Leu Gln Pro His Val Asp Ser Gln
              20                  25                  30        
 Glu Asp Leu Thr Phe Leu Trp Asp Met Phe Gly Glu Lys Ser Leu His
          35                  40                  45            
 Ser Leu Val Lys Ile His Glu Lys Leu His Tyr Tyr Glu Lys Gln Ser
      50                  55                  60                
 Pro Val Pro Ile Leu His Gly Ala Ala Ala Leu Ala Asp Asp Leu Ala
  65                  70                  75                  80
 Glu Glu Leu Gln Asn Lys Pro Leu Asn Ser Glu Ile Arg Glu Leu Leu
                  85                  90                  95    
 Lys Leu Leu Ser Lys Pro Asn Val Lys Ala Leu Leu Ser Val His Asp
             100                 105                 110        
 Thr Val Ala Gln Lys Asn Tyr Asp Pro Val Leu Pro Pro Met Pro Glu
         115                 120                 125            
 Asp Ile Asp Asp Glu Glu Asp Ser Val Lys Ile Ile Arg Leu Val Lys
     130                 135                 140                
 Asn Arg Glu Pro Leu Gly Ala Thr Ile Lys Lys Asp Glu Gln Thr Gly
 145                 150                 155                 160
 Ala Ile Ile Val Ala Arg Ile Met Arg Gly Gly Ala Ala Asp Arg Ser
                 165                 170                 175    
 Gly Leu Ile His Val Gly Asp Glu Leu Arg Glu Val Asn Gly Ile Pro
             180                 185                 190        
 Val Glu Asp Lys Arg Pro Glu Glu Ile Ile Gln Ile Leu Ala Gln Ser
         195                 200                 205            
 Gln Gly Ala Ile Thr Phe Lys Ile Ile Pro Gly Ser Lys Glu Glu Thr
     210                 215                 220                
 Pro Ser Lys Glu Gly Lys Met Phe Ile Lys Ala Leu Phe Asp Tyr Asn
 225                 230                 235                 240
 Pro Asn Glu Asp Lys Ala Ile Pro Cys Lys Glu Ala Gly Leu Ser Phe
                 245                 250                 255    
 Lys Lys Gly Asp Ile Leu Gln Ile Met Ser Gln Asp Asp Ala Thr Trp
             260                 265                 270        
 Trp Gln Ala Lys His Glu Ala Asp Ala Asn Pro Arg Ala Gly Leu Ile
         275                 280                 285            
 Pro Ser Lys His Phe Gln Glu Arg Arg Leu Ala Leu Arg Arg Pro Glu
     290                 295                 300                
 Ile Leu Val Gln Pro Leu Lys Val Ser Asn Arg Lys Ser Ser Gly Phe
 305                 310                 315                 320
 Arg Lys Ser Phe Arg Leu Ser Arg Lys Asp Lys Lys Thr Asn Lys Ser
                 325                 330                 335    
 Met Tyr Glu Cys Lys Lys Ser Asp Gln Tyr Asp Thr Ala Asp Val Pro
             340                 345                 350        
 Thr Tyr Glu Glu Val Thr Pro Tyr Arg Arg Gln Thr Asn Glu Lys Tyr
         355                 360                 365            
 Arg Leu Val Val Leu Val Gly Pro Val Gly Val Gly Leu Asn Glu Leu
     370                 375                 380                
 Lys Arg Lys Leu Leu Ile Ser Asp Thr Gln His Tyr Gly Val Thr Val
 385                 390                 395                 400
 Pro His Thr Thr Arg Ala Arg Arg Ser Gln Glu Ser Asp Gly Val Glu
                 405                 410                 415    
 Tyr Ile Phe Ile Ser Lys His Leu Phe Glu Thr Asp Val Gln Asn Asn
             420                 425                 430        
 Lys Phe Ile Glu Tyr Gly Glu Tyr Lys Asn Asn Tyr Tyr Gly Thr Ser
         435                 440                 445            
 Ile Asp Ser Val Arg Ser Val Leu Ala Lys Asn Lys Val Cys Leu Leu
     450                 455                 460                
 Asp Val Gln Pro His Thr Val Lys His Leu Arg Thr Leu Glu Phe Lys
 465                 470                 475                 480
 Pro Tyr Val Ile Phe Ile Lys Pro Pro Ser Ile Glu Arg Leu Arg Glu
                 485                 490                 495    
 Thr Arg Lys Asn Ala Lys Ile Ile Ser Ser Arg Asp Asp Gln Gly Ala
             500                 505                 510        
 Ala Lys Pro Phe Thr Val Ser Ile Met Met Leu Gly Gly Gln Glu Glu
         515                 520                 525            
 Asp Phe Gln Glu Met Ile Lys Ser Ala Gln Ile Met Glu Ser Gln Tyr
     530                 535                 540                
 Gly His Leu Phe Asp Lys Ile Ile Ile Asn Asp Asp Leu Thr Val Ala
 545                 550                 555                 560
 Phe Asn Glu Leu Lys Thr Thr Phe Asp Lys Leu Glu Thr Glu Thr His
                 565                 570                 575    
 Trp Val Pro Val Ser Trp Leu His Ser
             580                 585



      <210> 821
      <211> 386
      <212> PRT
      <213> Homo sapiens


      <400> 821
 Met Thr His Ala Asp Arg Ser Thr Ser Ser Ala Lys Lys Pro Leu Ser
   1               5                  10                  15    
 Ala Arg Arg Phe Phe Ala Ala Ser Gln Ala Pro Phe Lys Pro Arg Val
              20                  25                  30        
 Gly Pro Lys Cys Leu Ala Ser Ser Arg Lys Ala Ser Asp Val His Pro
          35                  40                  45            
 Ile Gln Gly Glu Trp Thr Glu Lys Thr Thr Thr Pro Gly Gly Gly Gly
      50                  55                  60                
 Glu Lys Met Ala Asp Asp Pro Ser Ala Ala Asp Arg Asn Val Glu Ile
  65                  70                  75                  80
 Trp Lys Ile Lys Lys Leu Ile Lys Ser Leu Glu Ala Ala Arg Gly Asn
                  85                  90                  95    
 Gly Thr Ser Met Ile Ser Leu Ile Ile Pro Pro Lys Asp Gln Ile Ser
             100                 105                 110        
 Arg Val Ala Lys Met Leu Ala Asp Glu Phe Gly Thr Ala Ser Asn Ile
         115                 120                 125            
 Lys Ser Arg Val Asn Arg Leu Ser Val Leu Gly Ala Ile Thr Ser Val
     130                 135                 140                
 Gln Gln Arg Leu Lys Leu Tyr Asn Lys Val Pro Pro Asn Gly Leu Val
 145                 150                 155                 160
 Val Tyr Cys Gly Thr Ile Val Thr Glu Glu Gly Lys Glu Lys Lys Val
                 165                 170                 175    
 Asn Ile Asp Phe Glu Pro Phe Lys Pro Ile Asn Thr Ser Leu Tyr Leu
             180                 185                 190        
 Cys Asp Asn Lys Phe His Thr Glu Ala Leu Thr Ala Leu Leu Ser Asp
         195                 200                 205            
 Asp Ser Lys Phe Gly Phe Ile Val Ile Asp Gly Ser Gly Ala Leu Phe
     210                 215                 220                
 Gly Thr Leu Gln Gly Asn Thr Arg Glu Val Leu His Lys Phe Thr Val
 225                 230                 235                 240
 Asp Leu Pro Lys Lys His Gly Arg Gly Gly Gln Ser Ala Leu Arg Phe
                 245                 250                 255    
 Ala Arg Leu Arg Met Glu Lys Arg His Asn Tyr Val Arg Lys Val Ala
             260                 265                 270        
 Glu Thr Ala Val Gln Leu Phe Ile Ser Gly Asp Lys Val Asn Val Ala
         275                 280                 285            
 Gly Leu Val Leu Ala Gly Ser Ala Asp Phe Lys Thr Glu Leu Ser Gln
     290                 295                 300                
 Ser Asp Met Phe Asp Gln Thr Gly Gln Glu His Glu Leu Ile Glu Ser
 305                 310                 315                 320
 Met Pro Leu Leu Glu Trp Phe Ala Asn Asn Tyr Lys Lys Phe Gly Ala
                 325                 330                 335    
 Thr Leu Glu Ile Val Thr Asp Lys Ser Gln Glu Gly Ser Gln Phe Val
             340                 345                 350        
 Lys Gly Phe Gly Gly Ile Gly Gly Ile Leu Arg Tyr Arg Val Asp Phe
         355                 360                 365            
 Gln Gly Met Glu Tyr Gln Gly Gly Asp Asp Glu Phe Phe Asp Leu Asp
     370                 375                 380                
 Asp Tyr
 385    



      <210> 822
      <211> 125
      <212> PRT
      <213> Homo sapiens


      <400> 822
 Met Glu Leu Met Phe Ala Glu Trp Glu Asp Gly Glu Arg Phe Ser Phe
   1               5                  10                  15    
 Glu Asp Ser Asp Arg Phe Glu Glu Asp Ser Leu Cys Ser Phe Ile Ser
              20                  25                  30        
 Glu Ala Glu Ser Leu Cys Gln Asn Trp Arg Gly Trp Arg Lys Gln Ser
          35                  40                  45            
 Ala Gly Pro Asn Ser Pro Thr Gly Gly Gly Gly Gly Gly Gly Ser Gly
      50                  55                  60                
 Gly Thr Arg Met Arg Gly Glu Ser Glu Leu Gly Gly Arg Gly Ser Ala
  65                  70                  75                  80
 Gly Pro Ala Trp Ala Ser Leu Gly Ser Cys Pro Gly Pro Gly Ala Val
                  85                  90                  95    
 Pro Asp Gln Glu Leu Ser Ser Thr Arg Gly Arg Lys Gly Ser Cys Pro
             100                 105                 110        
 Arg Pro Gly Ala Val Pro Asp Trp Glu Leu Ser Gln Ala
         115                 120                 125



      <210> 823
      <211> 190
      <212> PRT
      <213> Homo sapiens


      <400> 823
 Met Pro Lys Gly Lys Glu Ala Lys Gly Lys Lys Leu Ala Leu Ala Pro
   1               5                  10                  15    
 Ala Phe Val Lys Lys Gln Glu Ala Lys Lys Val Val Asn Pro Leu Phe
              20                  25                  30        
 Glu Lys Arg Pro Lys Asn Phe Gly Ile Gly Gln Asp Ile Gln Pro Lys
          35                  40                  45            
 Arg Asp Leu Thr Cys Phe Val Lys Trp Pro Arg Tyr Ile Arg Leu Gln
      50                  55                  60                
 Trp Gln Arg Ser Ile Leu Tyr Lys Gln Leu Lys Val Pro Pro Ala Ile
  65                  70                  75                  80
 Asn Gln Phe Thr Gln Ala Leu Glu Gly Gln Thr Ala Thr Gln Leu Leu
                  85                  90                  95    
 Lys Leu Ala His Lys Tyr Arg Pro Glu Thr Lys Gln Glu Lys Lys Arg
             100                 105                 110        
 Arg Leu Leu Ala Gln Ala Glu Leu Lys Thr Tyr Thr Thr Val Asp Phe
         115                 120                 125            
 Thr Gln Val Asn Ser Glu Asp Lys Gly Ala Leu Ala Lys Leu Met Glu
     130                 135                 140                
 Ala Ile Gly Thr Asn Tyr Asn Ala Arg Tyr Asp Glu Thr His Cys His
 145                 150                 155                 160
 Trp Asp Gly Asn Val Leu Gly Pro Lys Ser Val Ala His Ile Ala Lys
                 165                 170                 175    
 Leu Glu Lys Ala Lys Ala Lys Glu Leu Ala Thr Lys Leu Gly
             180                 185                 190



      <210> 824
      <211> 223
      <212> PRT
      <213> Homo sapiens


      <400> 824
 Met Thr Gly Thr Pro Gly Ala Val Ala Thr Arg Asp Gly Glu Ala Pro
   1               5                  10                  15    
 Glu Arg Ser Pro Pro Cys Ser Pro Ser Tyr Asp Leu Thr Gly Lys Val
              20                  25                  30        
 Met Leu Leu Gly Asp Thr Gly Val Gly Lys Thr Cys Phe Leu Ile Gln
          35                  40                  45            
 Phe Lys Asp Gly Ala Phe Leu Ser Gly Thr Phe Ile Ala Thr Val Gly
      50                  55                  60                
 Ile Asp Phe Arg Asn Lys Val Val Thr Val Asp Gly Val Arg Val Lys
  65                  70                  75                  80
 Leu Gln Ile Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg Ser Val Thr
                  85                  90                  95    
 His Ala Tyr Tyr Arg Asp Ala Gln Ala Leu Leu Leu Leu Tyr Asp Ile
             100                 105                 110        
 Thr Asn Lys Ser Ser Phe Asp Asn Ile Arg Ala Trp Leu Thr Glu Ile
         115                 120                 125            
 His Glu Tyr Ala Gln Arg Asp Val Val Ile Met Leu Leu Gly Asn Lys
     130                 135                 140                
 Ala Asp Met Ser Ser Glu Arg Val Ile Arg Ser Glu Asp Gly Glu Thr
 145                 150                 155                 160
 Leu Ala Arg Glu Tyr Gly Val Pro Phe Leu Glu Thr Ser Ala Lys Thr
                 165                 170                 175    
 Gly Met Asn Val Glu Leu Ala Phe Leu Ala Ile Ala Lys Glu Leu Lys
             180                 185                 190        
 Tyr Arg Ala Gly His Gln Ala Asp Glu Pro Ser Phe Gln Ile Arg Asp
         195                 200                 205            
 Tyr Val Glu Ser Gln Lys Lys Arg Ser Ser Cys Cys Ser Phe Met
     210                 215                 220            



      <210> 825
      <211> 339
      <212> PRT
      <213> Homo sapiens


      <400> 825
 Met Ala Glu Lys Arg Pro Leu Arg Thr Leu Gly Pro Val Met Tyr Gly
   1               5                  10                  15    
 Lys Leu Pro Arg Leu Glu Thr Asp Ser Gly Leu Glu His Ser Leu Pro
              20                  25                  30        
 His Ser Val Gly Asn Gln Asp Pro Cys Thr Tyr Lys Gly Ser Tyr Phe
          35                  40                  45            
 Ser Cys Pro Met Ala Gly Thr Pro Lys Ala Glu Ser Glu Gln Leu Ala
      50                  55                  60                
 Ser Trp Thr Pro Tyr Pro Pro Leu Tyr Ser Thr Gly Met Ala Gly Pro
  65                  70                  75                  80
 Pro Leu Gln Ala Asp Asn Leu Leu Thr Asn Cys Leu Phe Tyr Arg Ser
                  85                  90                  95    
 Pro Ala Glu Gly Pro Glu Lys Met Gln Asp Ser Ser Pro Val Glu Leu
             100                 105                 110        
 Leu Pro Phe Ser Pro Gln Ala His Ser Tyr Pro Gly Pro Pro Leu Ala
         115                 120                 125            
 Ala Pro Lys Pro Val Tyr Arg Asn Pro Leu Cys Tyr Gly Leu Ser Thr
     130                 135                 140                
 Cys Leu Gly Glu Gly Ala Val Lys Arg Pro Leu Asp Val Asp Trp Thr
 145                 150                 155                 160
 Leu Ala Thr Gly Pro Leu Leu Pro Ser Ala Asp Pro Pro Cys Ser Leu
                 165                 170                 175    
 Ala Pro Ala Pro Ser Lys Gly Gln Thr Leu Asp Gly Thr Phe Leu Arg
             180                 185                 190        
 Gly Val Pro Ala Glu Gly Ser Ser Lys Asp Ser Ser Gly Ser Phe Ser
         195                 200                 205            
 Pro Cys Gln Pro Phe Leu Glu Lys Tyr Gln Thr Ile His Ser Thr Gly
     210                 215                 220                
 Phe Leu Ala Ser Arg Tyr Thr Gly Pro Tyr Pro Arg Asn Ser Lys Gln
 225                 230                 235                 240
 Ala Met Ser Glu Gly Pro Ser Ser Pro Trp Thr Gln Leu Ala Gln Pro
                 245                 250                 255    
 Leu Gly Pro Pro Cys Gln Asp Thr Gly Pro Thr His Tyr Pro Pro Pro
             260                 265                 270        
 Pro Pro Pro Ser Asp His Thr Ala Ser Thr Gly Pro Ala Glu Arg Pro
         275                 280                 285            
 Ile Gln Ala Tyr Val Gln His Pro Glu Ala Ser Arg Asp Lys His Thr
     290                 295                 300                
 Asp Pro Ser Arg Leu Pro Pro Ser Arg Pro Asn Lys Ser Gln Arg Pro
 305                 310                 315                 320
 Arg Arg Gly Gln Thr Gln Asn Thr Arg Ala Arg Ile Gly Ala Gly Asp
                 325                 330                 335    
 Lys Thr His
            



      <210> 826
      <211> 1159
      <212> PRT
      <213> Homo sapiens


      <400> 826
 Met Gly Val Tyr Pro Thr Asp Leu Thr Leu Gln Leu Leu Ala Val Arg
   1               5                  10                  15    
 Arg Lys Ser Arg Leu Arg Asp Pro Gly Leu Gln Gln Thr Leu Arg Gly
              20                  25                  30        
 Gln Leu Arg Leu Leu Glu Asn Asp Ser Arg Glu Met Ala Arg Val Leu
          35                  40                  45            
 Gly Glu Leu Ser Ala Arg Leu Leu Ser Ile His Ser Asp Gln Asp Arg
      50                  55                  60                
 Ile Val Val Thr Phe Lys Thr Phe Glu Glu Ile Trp Lys Phe Ser Thr
  65                  70                  75                  80
 Tyr His Ala Leu Gly Phe Thr His His Cys Leu Ala Asn Leu Leu Met
                  85                  90                  95    
 Asp Gln Ala Phe Trp Leu Leu Leu Pro Ser Glu Glu Glu Glu Thr Ala
             100                 105                 110        
 Ile Gln Val His Val Asp Glu Asn Ala Leu Arg Leu Thr His Glu Ser
         115                 120                 125            
 Leu Leu Ile Gln Glu Gly Pro Phe Phe Val Leu Cys Pro Asp His His
     130                 135                 140                
 Val Arg Val Met Thr Gly Pro Arg Asp Ala Gly Asn Gly Pro Gln Ala
 145                 150                 155                 160
 Leu Arg Gln Ala Ser Gly Ala Pro Gln Gly Glu Ala Ala Pro Glu Thr
                 165                 170                 175    
 Asp Ser Ser Pro Pro Ser Pro Ser Val Ser Ser Glu Glu Val Ala Val
             180                 185                 190        
 Ala Ala Ala Pro Glu Pro Leu Ile Pro Phe His Gln Trp Ala Leu Arg
         195                 200                 205            
 Ile Pro Gln Asp Pro Ile Asp Asp Ala Met Gly Gly Pro Val Met Pro
     210                 215                 220                
 Gly Asn Pro Leu Met Ala Val Gly Leu Ala Ser Ala Leu Ala Asp Phe
 225                 230                 235                 240
 Gln Gly Ser Gly Pro Glu Glu Met Thr Phe Arg Gly Gly Asp Leu Ile
                 245                 250                 255    
 Glu Ile Leu Gly Ala Gln Val Pro Ser Leu Pro Trp Cys Val Gly Arg
             260                 265                 270        
 His Ala Ala Ser Gly Arg Val Gly Phe Val Arg Ser Ser Leu Ile Ser
         275                 280                 285            
 Met Gln Gly Pro Val Ser Glu Leu Glu Ser Ala Ile Phe Leu Asn Glu
     290                 295                 300                
 Glu Glu Lys Ser Phe Phe Ser Glu Gly Cys Phe Ser Glu Glu Asp Ala
 305                 310                 315                 320
 Arg Gln Leu Leu Arg Arg Met Ser Gly Thr Asp Val Cys Ser Val Tyr
                 325                 330                 335    
 Ser Leu Asp Ser Val Glu Glu Ala Glu Thr Glu Gln Pro Gln Glu Lys
             340                 345                 350        
 Glu Ile Pro Pro Pro Cys Leu Ser Pro Glu Pro Gln Glu Thr Leu Gln
         355                 360                 365            
 Lys Val Lys Asn Val Leu Glu Gln Cys Lys Thr Cys Pro Gly Cys Pro
     370                 375                 380                
 Gln Glu Pro Ala Ser Trp Gly Leu Cys Ala Ala Ser Ser Asp Val Ser
 385                 390                 395                 400
 Leu Gln Asp Pro Glu Glu Pro Ser Phe Cys Leu Glu Ala Glu Asp Asp
                 405                 410                 415    
 Trp Glu Asp Pro Glu Ala Leu Ser Ser Leu Leu Leu Phe Leu Asn Ala
             420                 425                 430        
 Pro Gly Tyr Lys Ala Ser Phe Arg Gly Leu Tyr Asp Val Ala Leu Pro
         435                 440                 445            
 Trp Leu Ser Ser Val Phe Arg Ser Phe Ser Asp Glu Glu Glu Leu Thr
     450                 455                 460                
 Gly Arg Leu Ala Gln Ala Arg Gly Ala Ala Lys Lys Ala Gly Leu Leu
 465                 470                 475                 480
 Met Ala Leu Ala Arg Leu Cys Phe Leu Leu Gly Arg Leu Cys Ser Arg
                 485                 490                 495    
 Arg Leu Lys Leu Ser Gln Ala Arg Val Tyr Phe Glu Glu Ala Leu Gly
             500                 505                 510        
 Ala Leu Glu Gly Ser Phe Gly Asp Leu Phe Leu Val Val Ala Val Tyr
         515                 520                 525            
 Ala Asn Leu Ala Ser Ile Tyr Arg Lys Gln Lys Asn Arg Glu Lys Cys
     530                 535                 540                
 Ala Gln Val Val Pro Lys Ala Met Ala Leu Leu Leu Gly Thr Pro Asp
 545                 550                 555                 560
 His Ile Cys Ser Thr Glu Ala Glu Gly Glu Leu Leu Gln Leu Ala Leu
                 565                 570                 575    
 Arg Arg Ala Val Gly Gly Gln Ser Leu Gln Ala Glu Ala Arg Ala Cys
             580                 585                 590        
 Phe Leu Leu Ala Arg His His Val His Leu Lys Gln Pro Glu Glu Ala
         595                 600                 605            
 Leu Pro Phe Leu Glu Arg Leu Leu Leu Leu His Arg Asp Ser Gly Ala
     610                 615                 620                
 Pro Glu Ala Ala Trp Leu Ser Asp Cys Tyr Leu Leu Leu Ala Asp Ile
 625                 630                 635                 640
 Tyr Ser Arg Lys Cys Leu Pro His Leu Val Leu Ser Cys Val Lys Val
                 645                 650                 655    
 Ala Ser Leu Arg Thr Arg Gly Ser Leu Ala Gly Ser Leu Arg Ser Val
             660                 665                 670        
 Asn Leu Val Leu Gln Asn Ala Pro Gln Pro His Ser Leu Pro Ala Gln
         675                 680                 685            
 Thr Ser His Tyr Leu Arg Gln Ala Leu Ala Ser Leu Thr Pro Gly Thr
     690                 695                 700                
 Gly Gln Ala Leu Arg Gly Pro Leu Tyr Thr Ser Leu Ala Gln Leu Tyr
 705                 710                 715                 720
 Ser His His Gly Cys His Gly Pro Ala Ile Thr Phe Met Thr Gln Ala
                 725                 730                 735    
 Val Glu Ala Ser Ala Ile Ala Gly Val Arg Ala Ile Val Asp His Leu
             740                 745                 750        
 Val Ala Leu Ala Trp Leu His Val Leu His Gly Gln Ser Pro Val Ala
         755                 760                 765            
 Leu Asp Ile Leu Gln Ser Val Arg Asp Ala Val Val Ala Ser Glu Asp
     770                 775                 780                
 Gln Glu Gly Val Ile Ala Asn Met Val Ala Val Ala Leu Lys Arg Thr
 785                 790                 795                 800
 Gly Arg Thr Arg Gln Ala Ala Glu Ser Tyr Tyr Arg Ala Leu Arg Val
                 805                 810                 815    
 Ala Arg Asp Leu Gly Gln Gln Arg Asn Gln Ala Val Gly Leu Ala Asn
             820                 825                 830        
 Phe Gly Ala Leu Cys Leu His Ala Gly Ala Ser Arg Leu Ala Gln His
         835                 840                 845            
 Tyr Leu Leu Glu Ala Val Arg Leu Phe Ser Arg Leu Pro Leu Gly Glu
     850                 855                 860                
 Cys Gly Arg Asp Phe Thr His Val Leu Leu Gln Leu Gly His Leu Cys
 865                 870                 875                 880
 Thr Arg Gln Gly Pro Ala Gln Gln Gly Lys Gly Tyr Tyr Glu Trp Ala
                 885                 890                 895    
 Leu Leu Val Ala Val Glu Met Gly His Val Glu Ser Gln Leu Arg Ala
             900                 905                 910        
 Val Gln Arg Leu Cys His Phe Tyr Ser Ala Val Met Pro Ser Glu Ala
         915                 920                 925            
 Gln Cys Val Ile Tyr His Glu Leu Gln Leu Ser Leu Ala Cys Lys Val
     930                 935                 940                
 Ala Asp Lys Val Leu Glu Gly Gln Leu Leu Glu Thr Ile Ser Gln Leu
 945                 950                 955                 960
 Tyr Leu Ser Leu Gly Thr Glu Arg Ala Tyr Lys Ser Ala Leu Asp Tyr
                 965                 970                 975    
 Thr Lys Arg Ser Leu Gly Ile Phe Ile Asp Leu Gln Lys Lys Glu Lys
             980                 985                 990        
 Glu Ala His Ala Trp Leu Gln Ala Gly Lys Ile Tyr Tyr Ile Leu Arg
         995                1000                1005            
 Gln Ser Glu Leu Val Asp Leu Tyr Ile Gln Val Ala Gln Asn Val Ala
    1010                1015                1020                
 Leu Tyr Thr Gly Asp Pro Asn Leu Gly Leu Glu Leu Phe Glu Ala Ala
1025                1030                1035                1040
 Gly Asp Ile Phe Phe Asp Gly Ala Trp Glu Arg Glu Lys Ala Val Ser
                1045                1050                1055    
 Phe Tyr Arg Asp Arg Ala Leu Pro Leu Ala Val Thr Thr Gly Asn Arg
            1060                1065                1070        
 Lys Ala Glu Leu Arg Leu Cys Asn Lys Leu Val Ala Leu Leu Ala Thr
        1075                1080                1085            
 Leu Glu Glu Pro Gln Glu Gly Leu Glu Phe Ala His Met Ala Leu Ala
    1090                1095                1100                
 Leu Ser Ile Thr Leu Gly Asp Arg Leu Asn Glu Arg Val Ala Tyr His
1105                1110                1115                1120
 Arg Leu Ala Ala Leu Gln His Arg Leu Gly His Gly Glu Leu Ala Glu
                1125                1130                1135    
 His Phe Tyr Leu Lys Ala Leu Ser Leu Cys Asn Ser Pro Leu Glu Phe
            1140                1145                1150        
 Asp Glu Glu Thr Leu Tyr Thr
        1155                



      <210> 827
      <211> 326
      <212> PRT
      <213> Homo sapiens


      <400> 827
 Met Thr Pro Cys Pro Arg Gly Glu Met Ser Trp Arg His Leu Leu Ser
   1               5                  10                  15    
 Leu Ile Asp Ala Glu Ser Ile Gln Lys Leu Pro Asp Gln Pro Ser His
              20                  25                  30        
 His Thr Gln Lys Arg Pro Phe Pro Ser Gly Glu Lys Leu Pro Asp Gln
          35                  40                  45            
 Pro Phe Thr His His Ser Gln Glu Ala Pro Phe Pro Pro Gly Glu Lys
      50                  55                  60                
 Leu Pro Asp Gln Pro Leu Ile Pro Gln Pro Arg Gly Ala Phe Leu Thr
  65                  70                  75                  80
 Trp Arg Glu Ile Ser Arg Pro Ser Pro Leu Thr Thr Ala Arg Arg Gly
                  85                  90                  95    
 Leu Ser His Arg Lys Arg Asn Phe Gln Thr Ser Pro Ser His His Ser
             100                 105                 110        
 Gln Glu Lys Pro Phe Gln Pro Gly Glu Lys Leu Pro Asp His Pro Leu
         115                 120                 125            
 Ser Pro Gln Pro Gly Glu Ala Phe Pro Gly Leu Glu Thr Ser Gly Gln
     130                 135                 140                
 Ala Ile Ser His Thr Thr Ala Arg Arg Gly Leu Ser His Leu Asp Arg
 145                 150                 155                 160
 Asn Phe Gln His Gln Pro Leu Ser Pro Gln Pro Gly Glu Ala Phe Thr
                 165                 170                 175    
 Thr Trp Arg Glu Ala Ser Arg Pro Ala Pro His Thr Thr Ala Arg Arg
             180                 185                 190        
 Gly Leu Ser His Leu Glu Arg Asn Phe Gln Thr Ser Pro Ser Tyr His
         195                 200                 205            
 Ser Gln Glu Gly Pro Phe Ser Pro Gly Glu Lys Leu Pro Asp Gln Pro
     210                 215                 220                
 Leu Thr Pro Pro Thr Gly Glu Ala Phe Pro Thr Gly Arg Glu Thr Ser
 225                 230                 235                 240
 Arg Pro Ala Pro His Ser Thr Ala Arg Arg Asp Leu Phe Cys Leu Glu
                 245                 250                 255    
 Arg Asn Phe Gln Thr Ser Pro Thr His His Ser Gln Glu Arg Pro Ile
             260                 265                 270        
 Leu Thr Gly Glu Lys Leu Pro Asp Ser Pro Ser Gln His Ser Gln Glu
         275                 280                 285            
 Arg Pro Phe Pro Pro Gly Glu Lys Leu Pro Glu Gln Thr Leu Leu Thr
     290                 295                 300                
 Thr Ala Arg Arg Gly Val Pro Pro Gly Thr Asp Asn Leu Leu Pro Leu
 305                 310                 315                 320
 His Gly Ala Ser Arg Asp
                 325    



      <210> 828
      <211> 84
      <212> PRT
      <213> Homo sapiens


      <400> 828
 Met Pro Phe Ala Lys Val Phe Leu Leu Pro Ser Pro Lys Lys Glu Lys
   1               5                  10                  15    
 Arg Lys Pro Lys Lys Lys Arg Leu Gly Gln Ser Pro His Ser Tyr Phe
              20                  25                  30        
 Lys Asp Val Lys Cys Pro Gly Cys Tyr Lys Ile Pro Pro Val Phe Thr
          35                  40                  45            
 His Ala Gln Thr Val Val Leu Gly Val Gly Trp Ser Pro Val Leu Cys
      50                  55                  60                
 Pro Pro Pro Gly Gly Lys Thr Arg Leu Pro Lys Gly Cys Ser Phe Arg
  65                  70                  75                  80
 Arg Lys Pro Pro
                



      <210> 829
      <211> 148
      <212> PRT
      <213> Homo sapiens


      <400> 829
 Met Val Ala Ala Ala Ala Pro Ser Ser Ala Leu Ala Cys Leu Arg Pro
   1               5                  10                  15    
 Pro Arg Gly Tyr Pro Ala Cys Arg Ser Arg Ala Ala Arg Pro Gly Trp
              20                  25                  30        
 Arg Trp Gly Arg Ala Glu Ala Ala Glu Val Leu Arg Ala Thr Gly Gly
          35                  40                  45            
 Trp Gln Trp Ala Gly Glu Arg Gly Arg Gln Ala Arg Leu Gly Leu Trp
      50                  55                  60                
 Leu Trp Arg Arg Gly Thr Leu Cys Leu Gly Ser Leu Thr Ala Pro Pro
  65                  70                  75                  80
 Gly Ser Pro Glu Arg Gly Thr Gly Gly Glu Gly Gly Gly Ser Trp Ala
                  85                  90                  95    
 Pro Cys Ala Ala Gly Pro Arg Gly Ala Arg Val Ala Ala Gly Ser Ala
             100                 105                 110        
 Gly Pro Asp Arg Val Asn Gly Arg Ala Trp Pro Val Pro Arg Gly Ala
         115                 120                 125            
 Pro Ala Ala Thr Ala Leu Ala Ala Gly Thr Gly Val Leu Arg Gly Arg
     130                 135                 140                
 Ser Leu Pro Phe
 145            



      <210> 830
      <211> 527
      <212> PRT
      <213> Homo sapiens


      <400> 830
 Met Ser Arg Ala Ala Ala Ala Ala Gly Pro Pro Arg Gln Ala Thr Pro
   1               5                  10                  15    
 Ala Ser Pro Arg Trp Ser Asn Asp Cys Val Leu Arg Arg Glu Cys Ser
              20                  25                  30        
 Asn Pro Ile Gly His Thr Leu Gln His Tyr Pro Gly Arg Tyr Gln Asp
          35                  40                  45            
 His Val Gln Leu Glu Ile Pro Asn Arg Val Leu Asn Ser Pro Val Thr
      50                  55                  60                
 Lys Thr Pro Ser Arg Asp Pro Pro Thr Thr Ser Gly Val Thr Ser Pro
  65                  70                  75                  80
 Ala Ser Asp Glu Pro Pro Ala Asp Thr Gln Thr Ala Gln Asn Ser Arg
                  85                  90                  95    
 Gln Val Val Lys Gly Gln Ser Leu Thr Trp Thr Ser Lys Gly Leu Ala
             100                 105                 110        
 Met Arg Arg Lys Gly Ser Arg Asp Leu Val Val Asp Ser Ala Lys Ser
         115                 120                 125            
 Leu Glu Asp Gly Pro Ser Ala Ala Leu His Ser Lys Leu Tyr Glu Ala
     130                 135                 140                
 Ile Met Arg Glu Asp Cys Thr Thr Ile Glu Val Leu Leu Arg Asn His
 145                 150                 155                 160
 Pro Val Asn Gln Pro Ile Thr Ile Leu Pro Asn Ser Ala Ser Asn Arg
                 165                 170                 175    
 Leu Leu Leu Thr Gln Pro Thr Glu Ser Ile Ile Pro Ile His Leu Ala
             180                 185                 190        
 Ala Lys Tyr His Lys Ala Gln Ser Leu Leu Cys Leu Leu Arg His Gly
         195                 200                 205            
 Ala Asp Pro Glu Val Arg Asp Thr Thr Gly Leu Thr Thr Leu Asn Leu
     210                 215                 220                
 Met Leu Leu His Trp Pro Val Thr Ser Thr Thr Trp Ala Lys Pro Gly
 225                 230                 235                 240
 Asn Arg Thr His Arg Ile Leu Thr Asp Ile Gln Asn Ser Ser Ile Thr
                 245                 250                 255    
 Cys Leu Arg Ile Leu Cys Ala His Gly Ala Gln Val Asn Thr Gln Gly
             260                 265                 270        
 Glu Ile Ser Asn Lys Arg Ser Pro Leu His Leu Ala Ile Ala Tyr Gly
         275                 280                 285            
 Cys Tyr Pro Val Leu Ser Ile Leu Thr Gln Asn Gly Ala Asp Val Asn
     290                 295                 300                
 Ala Ile Asn Glu Ala Ser Met Thr Pro Leu His Met Ala Ala Asn Met
 305                 310                 315                 320
 Leu Asn Lys Glu Met Met Glu Thr Leu Ile Ala Tyr Gly Ala Asn Val
                 325                 330                 335    
 Asn Cys Ala Val Ser Ser Thr Gly Asn Thr Pro Leu Lys Leu Ala Val
             340                 345                 350        
 Cys Thr Ala Ser Ser Lys Ala Gly Arg Leu Leu Gly Ala Gly Val Ser
         355                 360                 365            
 Cys Ile Arg Leu Leu Leu Thr His Gly Ala Lys Val Asn Ala Gln Asp
     370                 375                 380                
 Tyr Lys Gly Gln Thr Ala Ile His Glu Ala Cys Phe Gly Gly Arg Glu
 385                 390                 395                 400
 Ala Ile Ile Asn Leu Leu Leu Glu Phe Glu Ala Asn Val Asn Ile Leu
                 405                 410                 415    
 Thr Arg Asn Gly Glu Ser Pro Ile Tyr Met Tyr Leu Gln Arg Ser Cys
             420                 425                 430        
 Asn Val Arg Asp Thr Ala Leu Leu Ala Arg Leu Leu Tyr His Thr Tyr
         435                 440                 445            
 Pro Leu Arg Met Thr Asn Asn Gln Gly Ile Leu Pro Ala Gly Ile Met
     450                 455                 460                
 Leu Pro Glu Phe Arg Leu Leu Arg Asp Thr Leu Ile Lys Gln Ser Gln
 465                 470                 475                 480
 Lys Pro Leu Ser Leu Gln Gly Ile Cys Lys Arg Asn Ile Arg Asn Ile
                 485                 490                 495    
 Tyr Gly Glu Lys Tyr Lys Gln His Leu Lys Gln Phe Leu Pro Val Thr
             500                 505                 510        
 Ile Trp Asn Ser Val Tyr Cys Cys Tyr Asp Leu Ala Tyr Thr Ser
         515                 520                 525        



      <210> 831
      <211> 187
      <212> PRT
      <213> Homo sapiens


      <400> 831
 Met Gln Asp Glu Pro Tyr Gln Ala Leu Val Ala Glu Leu His Arg Arg
   1               5                  10                  15    
 Ala Leu Val Glu Tyr Val Arg Pro Leu Leu Arg Gly Arg Leu Arg Cys
              20                  25                  30        
 Ser Ser Ala Arg Thr Arg Ser Arg Val Ala Gly Arg Leu Arg Glu Asp
          35                  40                  45            
 Ala Ala His Cys Arg Gly Cys Ser Gly Gly Trp Ser Pro Arg Pro Arg
      50                  55                  60                
 Gly Trp Met Pro Trp Cys Pro Ile Trp Leu Lys Ser Cys Ser Trp Lys
  65                  70                  75                  80
 Thr Arg Pro Ala Ser Arg Trp Arg Trp Glu Cys Trp Cys Ala Thr Thr
                  85                  90                  95    
 Gln Thr Ser Gly Arg Ser Thr Trp Gln Pro Ser Ser Thr Ser Val Ala
             100                 105                 110        
 Cys Ala Thr Gln Pro Pro Ala Arg Arg Ser Trp Pro Trp Pro Gly Thr
         115                 120                 125            
 Trp Asn Ser Leu Arg Arg Glu Pro Cys His Pro Leu Gly Thr Val Pro
     130                 135                 140                
 Ser Leu Gln Thr Ser Leu Cys Pro Ala His Leu Ser Val Ser Ala Ser
 145                 150                 155                 160
 Leu Ser Ser Trp Ala Ala Ser Pro Ser Pro Gly Trp Pro Gly Pro Val
                 165                 170                 175    
 Trp Pro Val Cys Leu Gly Pro Gly Leu Arg Leu
             180                 185        



      <210> 832
      <211> 229
      <212> PRT
      <213> Homo sapiens


      <400> 832
 Met Asp Ser Leu Asp Arg Ser Cys Gln Asp Trp Cys Asp Arg Lys Gln
   1               5                  10                  15    
 His Trp Leu Glu Ile Gly Pro Pro Asp Leu Val Glu Arg Lys Gly Ser
              20                  25                  30        
 Leu Thr Leu Arg Ser His His Lys Lys Tyr Ser Lys Pro Val Leu Val
          35                  40                  45            
 Tyr Ser Trp His Arg Asp Arg Glu Ala Phe Pro Lys Gly Tyr Asp Ile
      50                  55                  60                
 Glu Gly Pro Glu Lys Val Lys Lys Leu Cys Asn Ser Thr Tyr Arg Arg
  65                  70                  75                  80
 Leu Gly Thr Asp Glu Ser Pro Ile Trp Thr Ser Glu Thr His Glu Lys
                  85                  90                  95    
 Leu Ser Gln Met Cys Leu Asn Thr Glu Trp Val Glu Met Lys Ser Lys
             100                 105                 110        
 Ala Leu Leu Asn Glu Glu Thr Val Ser Ser Gly Ile Ile Glu Arg Val
         115                 120                 125            
 Thr Gly Leu Pro Ala Thr Gly Phe Gly Ala Val Phe Pro Arg His Pro
     130                 135                 140                
 Pro Asp Trp Ser Lys Met Cys Ala Leu Thr Thr Tyr Ser Glu Asp Tyr
 145                 150                 155                 160
 Val Pro Pro Tyr Asp Tyr Gln Pro His Ala Tyr Pro Cys Gln Asp Asp
                 165                 170                 175    
 Tyr Ser Ile Val His Arg Lys Cys Arg Ser Gln Phe Thr Asp Leu Asn
             180                 185                 190        
 Gly Ser Lys Arg Phe Gly Ile Asn Thr Trp His Asp Glu Ser Gly Ile
         195                 200                 205            
 Tyr Ala Asn Ser Asp Val Lys Gln Lys Leu Tyr Pro Leu Thr Ser Gly
     210                 215                 220                
 Pro Ile Val Pro Ile
 225                



      <210> 833
      <211> 295
      <212> PRT
      <213> Homo sapiens


      <400> 833
 Met Asp Asp Lys Glu Leu Ile Glu Tyr Phe Lys Ser Gln Met Lys Glu
   1               5                  10                  15    
 Asp Pro Asp Met Ala Ser Ala Val Ala Ala Ile Arg Thr Leu Leu Glu
              20                  25                  30        
 Phe Leu Lys Arg Asp Lys Gly Glu Thr Ile Gln Gly Leu Arg Ala Asn
          35                  40                  45            
 Leu Thr Ser Ala Ile Glu Thr Leu Cys Gly Val Asp Ser Ser Val Ala
      50                  55                  60                
 Val Ser Ser Gly Gly Glu Leu Phe Leu Arg Phe Ile Ser Leu Ala Ser
  65                  70                  75                  80
 Leu Glu Tyr Ser Asp Tyr Ser Lys Cys Lys Lys Ile Met Ile Glu Arg
                  85                  90                  95    
 Gly Glu Leu Phe Leu Arg Arg Ile Ser Leu Ser Arg Asn Lys Ile Ala
             100                 105                 110        
 Asp Leu Cys His Thr Phe Ile Lys Asp Gly Ala Thr Ile Leu Thr His
         115                 120                 125            
 Ala Tyr Ser Arg Val Val Leu Arg Val Leu Glu Ala Ala Val Ala Ala
     130                 135                 140                
 Lys Lys Arg Phe Ser Val Tyr Val Thr Glu Ser Gln Pro Asp Phe Lys
 145                 150                 155                 160
 Lys Met Ala Lys Ala Leu Cys His Leu Asn Val Pro Val Thr Val Val
                 165                 170                 175    
 Leu Asp Ala Ala Val Gly Tyr Ile Met Glu Lys Ala Asp Leu Val Ile
             180                 185                 190        
 Val Gly Ala Glu Gly Val Val Glu Asn Gly Gly Ile Ile Asn Lys Arg
         195                 200                 205            
 Ala Val Ser Gly Ser Ser Thr Leu Ile Thr His Thr Lys Ala Leu Pro
     210                 215                 220                
 Gly Gln Ser Thr Lys Tyr Ser Val Pro Thr Asn Val Tyr Phe Ser Pro
 225                 230                 235                 240
 Gln Tyr Lys Ala Asp Thr Leu Lys Val Ala Gln Thr Gly Gln Asp Leu
                 245                 250                 255    
 Lys Glu Glu His Pro Trp Val Asp Tyr Thr Ala Pro Ser Leu Ile Thr
             260                 265                 270        
 Leu Leu Phe Thr Asp Leu Gly Val Leu Thr Pro Ser Ala Val Ser Asp
         275                 280                 285            
 Glu Leu Ile Lys Leu Tyr Leu
     290                 295



      <210> 834
      <211> 475
      <212> PRT
      <213> Homo sapiens


      <400> 834
 Met Arg Gln Arg Asp Ser Gly Asp Trp Leu Ala Met Pro Ser Arg Ala
   1               5                  10                  15    
 Glu Asn Tyr Glu Val Leu Tyr Thr Ile Gly Thr Gly Ser Ser Gly Arg
              20                  25                  30        
 Cys Gln Lys Ile Gln Arg Lys Ser Asp Gly Lys Ile Leu Val Trp Lys
          35                  40                  45            
 Glu Leu Asp Tyr Gly Phe Met Thr Glu Ala Glu Lys Gln Met Leu Ile
      50                  55                  60                
 Ser Glu Val Asn Leu Leu Cys Lys Leu Lys Asn Pro Asn Ile Val His
  65                  70                  75                  80
 Tyr Tyr Asp Arg Ile Ile Asp Arg Thr Asn Thr Thr Leu Tyr Ile Val
                  85                  90                  95    
 Met Glu Tyr Cys Glu Glu Gly Asp Leu Ala Ser Val Ile Thr Lys Gly
             100                 105                 110        
 Thr Lys Glu Arg Gln Tyr Leu Asp Glu Glu Phe Val Leu Arg Val Thr
         115                 120                 125            
 Thr Gln Leu Thr Leu Ala Leu Lys Arg Ser Gly Gly Asp His Thr Val
     130                 135                 140                
 Val Arg Arg Asp Leu Lys Pro Ala Ser Val Phe Leu Asp Gly Lys Gln
 145                 150                 155                 160
 Asn Val Lys Leu Gly Asp Leu Gly Leu Ala Arg Ile Leu Asn His Asp
                 165                 170                 175    
 Thr Ser Phe Ala Lys Thr Phe Val Gly Thr Pro Tyr Tyr Met Ser Pro
             180                 185                 190        
 Glu Gln Thr Asn His Met Ser Tyr Asn Glu Lys Pro Asp Ile Trp Ser
         195                 200                 205            
 Leu Gly Arg Leu Leu Tyr Glu Leu Gly Ala Leu Met Pro Pro Phe Thr
     210                 215                 220                
 Ala Phe Ser Gln Lys Glu Leu Ala Gly Lys Ile Arg Glu Gly Lys Phe
 225                 230                 235                 240
 Arg Gln Ile Leu Tyr His Tyr Ser Asp Glu Leu Asn Glu Ile Ile Met
                 245                 250                 255    
 Arg Met Leu Lys Asp Tyr His Arg Pro Ser Val Glu Glu Ile Leu Glu
             260                 265                 270        
 Asn Pro Leu Ile Ala Asp Leu Val Ala Glu Glu Gln Arg Arg Asn Leu
         275                 280                 285            
 Glu Arg Arg Gly Arg Gln Leu Gly Glu Pro Glu Lys Leu Pro Asp Ser
     290                 295                 300                
 Ser Leu Val Leu Ser Glu Leu Lys Leu Lys Glu Ile Gln Leu Glu Glu
 305                 310                 315                 320
 Gln Glu Arg Ala Leu Lys Ala Gly Glu Glu Arg Leu Glu Gln Lys Glu
                 325                 330                 335    
 Gln Glu Leu Cys Val Cys Glu Arg Leu Ala Glu Asp Arg Leu Ala Ile
             340                 345                 350        
 Pro Glu Asn Leu Leu Lys Asn Tyr Ser Leu Leu Lys Glu Gln Lys Phe
         355                 360                 365            
 Leu Ser Leu Ala Ser Ser Pro Glu Leu Leu Asn Leu Pro Ser Ser Val
     370                 375                 380                
 Ile Lys Lys Lys Val His Phe Ser Gly Glu Ser Lys Glu Asn Val Met
 385                 390                 395                 400
 Arg Ser Glu Asn Ser Glu Ser Gln Leu Thr Ser Lys Ser Lys Cys Lys
                 405                 410                 415    
 Asp Leu Lys Val Pro Cys Phe Met Leu His Ala Ala Gln Leu Arg Ala
             420                 425                 430        
 Gln Ala Leu Ser Asp Phe Glu Lys Asn Tyr Gln Leu Ile Ser Glu Leu
         435                 440                 445            
 Gln Val Cys Glu Arg His Met Tyr Thr Cys Asn Glu Met Tyr Ser Phe
     450                 455                 460                
 Pro Phe Ile Ser Val Lys Gln Val Ser Leu Tyr
 465                 470                 475



      <210> 835
      <211> 336
      <212> PRT
      <213> Homo sapiens


      <400> 835
 Met Leu Gly Thr Arg Pro Ala Val Leu Asn Arg Pro Arg Arg Asn Arg
   1               5                  10                  15    
 Leu Ala Ser Ala Ala Met Ala Ala Gly Val Pro Cys Ala Leu Val Thr
              20                  25                  30        
 Ser Cys Ser Ser Val Phe Ser Gly Asp Gln Leu Val Gln His Ile Leu
          35                  40                  45            
 Gly Thr Glu Asp Leu Ile Val Glu Val Thr Ser Asn Asp Ala Val Arg
      50                  55                  60                
 Phe Tyr Pro Trp Thr Ile Asp Asn Lys Tyr Tyr Ser Ala Asp Ile Asn
  65                  70                  75                  80
 Leu Cys Val Val Pro Asn Lys Phe Leu Val Thr Ala Glu Ile Ala Glu
                  85                  90                  95    
 Ser Val Gln Ala Phe Val Val Tyr Phe Asp Ser Thr Gln Lys Ser Gly
             100                 105                 110        
 Leu Asp Ser Val Ser Ser Trp Leu Pro Leu Ala Lys Ala Trp Leu Pro
         115                 120                 125            
 Glu Val Met Ile Leu Val Cys Asp Arg Val Ser Glu Asp Gly Ile Asn
     130                 135                 140                
 Arg Gln Lys Ala Gln Glu Trp Cys Leu Lys His Gly Phe Glu Leu Val
 145                 150                 155                 160
 Glu Leu Ser Pro Glu Glu Leu Pro Glu Glu Asp Asp Asp Phe Pro Glu
                 165                 170                 175    
 Ser Thr Gly Val Lys Arg Ile Val Gln Ala Leu Asn Ala Asn Val Trp
             180                 185                 190        
 Ser Asn Val Val Met Lys Asn Asp Arg Asn Gln Gly Phe Ser Leu Leu
         195                 200                 205            
 Asn Ser Leu Thr Gly Thr Asn His Ser Ile Gly Ser Ala Asp Pro Cys
     210                 215                 220                
 His Pro Glu Gln Pro His Leu Pro Ala Ala Asp Ser Thr Glu Ser Leu
 225                 230                 235                 240
 Ser Asp His Arg Gly Gly Ala Ser Asn Thr Thr Asp Ala Gln Val Asp
                 245                 250                 255    
 Ser Ile Val Asp Pro Met Leu Asp Leu Asp Ile Gln Glu Leu Ala Ser
             260                 265                 270        
 Leu Thr Thr Gly Gly Gly Asp Val Glu Asn Phe Glu Arg Leu Phe Ser
         275                 280                 285            
 Lys Leu Lys Glu Met Lys Asp Lys Ala Ala Thr Leu Pro His Glu Gln
     290                 295                 300                
 Arg Lys Val His Ala Glu Lys Val Ala Lys Ala Phe Trp Met Ala Ile
 305                 310                 315                 320
 Gly Gly Asp Arg Asp Glu Ile Glu Gly Leu Ser Ser Asp Glu Glu His
                 325                 330                 335    





      <210> 836
      <211> 192
      <212> PRT
      <213> Homo sapiens


      <400> 836
 Met Ser Glu Val Lys His Ala Leu Thr Met Arg Gly Ile Pro Arg Gln
   1               5                  10                  15    
 Arg Ala Ala Leu Leu Gln Pro Arg His Glu Asn Ser Leu Leu Gly Lys
              20                  25                  30        
 Glu Ala Val Ser Val Ser Tyr Gly Cys Cys Asn Lys Val Arg Lys Thr
          35                  40                  45            
 Glu Trp Leu Gly Thr Ala Glu Ile Tyr Cys Leu Ser Ser Glu Gly His
      50                  55                  60                
 His Leu Lys Ser Arg Cys Gln Trp Gly His Ala Pro Tyr Glu Gly Thr
  65                  70                  75                  80
 Lys Thr Arg Asp Asp His Arg His Leu Asn Gln Phe Ile Ala His Ala
                  85                  90                  95    
 Ala Leu Asp Leu Val Asp Glu Asn Met Trp Leu Ser Asn Asn Met Tyr
             100                 105                 110        
 Leu Lys Thr Val Asp Lys Phe Asn Glu Trp Phe Val Ser Ala Phe Val
         115                 120                 125            
 Thr Ala Gly His Met Arg Phe Ile Met Leu His Asp Ile Arg Gln Glu
     130                 135                 140                
 Asp Gly Ile Lys Asn Phe Phe Thr Asp Val Tyr Asp Leu Tyr Ile Lys
 145                 150                 155                 160
 Phe Ser Met Asn Pro Phe Tyr Glu Pro Asn Ser Pro Ile Arg Ser Ser
                 165                 170                 175    
 Ala Phe Asp Arg Lys Val Gln Phe Leu Gly Lys Lys His Leu Leu Ser
             180                 185                 190        





      <210> 837
      <211> 445
      <212> PRT
      <213> Homo sapiens


      <400> 837
 Met Thr Met Phe Glu Asn Val Thr Arg Ala Leu Ala Arg Gln Leu Asn
   1               5                  10                  15    
 Pro Arg Gly Asp Leu Thr Pro Leu Asp Ser Leu Ile Asp Phe Lys Arg
              20                  25                  30        
 Phe His Pro Phe Cys Leu Val Leu Arg Lys Arg Lys Ser Thr Leu Phe
          35                  40                  45            
 Trp Gly Ala Arg Tyr Val Arg Thr Asp Tyr Thr Leu Leu Asp Val Leu
      50                  55                  60                
 Glu Pro Gly Ser Ser Pro Ser Asp Pro Thr Asp Thr Gly Asn Phe Gly
  65                  70                  75                  80
 Phe Lys Asn Met Leu Asp Thr Arg Val Glu Gly Asp Val Asp Val Pro
                  85                  90                  95    
 Lys Thr Val Lys Val Lys Gly Thr Ala Gly Leu Ser Gln Asn Ser Thr
             100                 105                 110        
 Leu Glu Val Gln Thr Leu Ser Val Ala Pro Lys Ala Leu Glu Thr Leu
         115                 120                 125            
 Gln Lys Arg Lys Leu Ala Ala Asp His Pro Phe Leu Lys Glu Met Gln
     130                 135                 140                
 Asp Gln Gly Glu Asn Leu Tyr Val Val Met Glu Val Val Glu Thr Val
 145                 150                 155                 160
 Gln Glu Val Thr Leu Glu Arg Ala Gly Lys Ala Glu Ala Cys Phe Ser
                 165                 170                 175    
 Leu Pro Phe Phe Ala Pro Leu Gly Leu Gln Gly Ser Ile Asn His Lys
             180                 185                 190        
 Glu Ala Val Thr Ile Pro Lys Gly Cys Val Leu Ala Phe Arg Val Arg
         195                 200                 205            
 Gln Leu Met Val Lys Gly Lys Asp Glu Trp Asp Ile Pro His Ile Cys
     210                 215                 220                
 Asn Asp Asn Met Gln Thr Phe Pro Pro Gly Glu Lys Ser Gly Glu Glu
 225                 230                 235                 240
 Lys Val Ile Leu Ile Gln Ala Ser Asp Val Gly Asp Val His Glu Gly
                 245                 250                 255    
 Phe Arg Thr Leu Lys Glu Glu Val Gln Arg Glu Thr Gln Gln Val Glu
             260                 265                 270        
 Lys Leu Ser Arg Val Gly Gln Ser Ser Leu Leu Ser Ser Leu Ser Lys
         275                 280                 285            
 Leu Leu Gly Lys Lys Lys Glu Leu Gln Asp Leu Glu Leu Ala Leu Glu
     290                 295                 300                
 Gly Ala Leu Asp Lys Gly His Glu Val Thr Leu Glu Ala Leu Pro Lys
 305                 310                 315                 320
 Asp Val Leu Leu Ser Lys Glu Ala Val Gly Ala Ile Leu Tyr Phe Val
                 325                 330                 335    
 Gly Ala Leu Thr Glu Leu Ser Glu Ala Gln Gln Lys Leu Leu Val Lys
             340                 345                 350        
 Ser Met Glu Lys Lys Ile Leu Pro Val Gln Leu Lys Leu Val Glu Ser
         355                 360                 365            
 Thr Met Glu Gln Asn Phe Leu Leu Asp Lys Glu Gly Val Phe Pro Leu
     370                 375                 380                
 Gln Pro Glu Leu Leu Ser Ser Leu Gly Asp Glu Glu Leu Thr Leu Thr
 385                 390                 395                 400
 Glu Ala Leu Val Gly Leu Ser Gly Leu Glu Val Gln Arg Ser Gly Pro
                 405                 410                 415    
 Gln Tyr Met Trp Asp Pro Asp Thr Leu Pro Arg Leu Cys Ala Leu Tyr
             420                 425                 430        
 Ala Gly Leu Ser Leu Leu Gln Gln Leu Thr Lys Ala Ser
         435                 440                 445



      <210> 838
      <211> 347
      <212> PRT
      <213> Homo sapiens


      <400> 838
 Met Ala Gly Ser Tyr Pro Glu Gly Ala Pro Ala Ile Leu Ala Asp Lys
   1               5                  10                  15    
 Arg Gln Gln Phe Gly Ser Arg Phe Leu Ser Asp Pro Ala Arg Val Phe
              20                  25                  30        
 His His Asn Ala Phe Asp Tyr Glu Ile Asn Ala His Lys Tyr Trp Asn
          35                  40                  45            
 Asp Phe Tyr Lys Ile His Glu Asn Gly Phe Phe Lys Asp Arg His Trp
      50                  55                  60                
 Leu Phe Thr Glu Phe Pro Glu Leu Ala Pro Ser Gln Asn Gln Asn His
  65                  70                  75                  80
 Leu Lys Asp Trp Phe Leu Glu Asn Lys Ser Glu Val Cys Glu Cys Arg
                  85                  90                  95    
 Asn Asn Glu Asp Gly Pro Gly Leu Ile Met Glu Glu Gln His Lys Cys
             100                 105                 110        
 Ser Ser Lys Ser Leu Glu His Lys Thr Gln Thr Pro Pro Val Glu Glu
         115                 120                 125            
 Asn Val Thr Gln Lys Ile Ser Asp Leu Glu Ile Cys Ala Asp Glu Phe
     130                 135                 140                
 Pro Gly Ser Ser Ala Thr Tyr Arg Ile Leu Glu Val Gly Cys Gly Val
 145                 150                 155                 160
 Gly Asn Thr Val Phe Pro Ile Leu Gln Thr Asn Asn Asp Pro Gly Leu
                 165                 170                 175    
 Phe Val Tyr Cys Cys Asp Phe Ser Ser Thr Ala Ile Glu Leu Val Gln
             180                 185                 190        
 Thr Asn Ser Glu Tyr Asp Pro Ser Arg Cys Phe Ala Phe Val His Asp
         195                 200                 205            
 Leu Cys Asp Glu Glu Lys Ser Tyr Pro Val Pro Lys Gly Ser Leu Asp
     210                 215                 220                
 Ile Ile Ile Leu Ile Phe Val Leu Ser Ala Ile Val Pro Asp Lys Met
 225                 230                 235                 240
 Gln Lys Ala Ile Asn Arg Leu Ser Arg Leu Leu Lys Pro Gly Gly Met
                 245                 250                 255    
 Val Leu Leu Arg Asp Tyr Gly Arg Tyr Asp Met Ala Gln Leu Arg Phe
             260                 265                 270        
 Lys Lys Gly Gln Cys Leu Ser Gly Asn Phe Tyr Val Arg Gly Asp Gly
         275                 280                 285            
 Thr Arg Val Tyr Phe Phe Thr Gln Glu Glu Leu Asp Thr Leu Phe Thr
     290                 295                 300                
 Thr Ala Gly Leu Glu Lys Val Gln Asn Leu Val Asp Arg Arg Leu Gln
 305                 310                 315                 320
 Val Asn Arg Gly Lys Gln Leu Thr Met Tyr Arg Val Trp Ile Gln Cys
                 325                 330                 335    
 Lys Tyr Cys Lys Pro Leu Leu Ser Ser Thr Ser
             340                 345        



      <210> 839
      <211> 166
      <212> PRT
      <213> Homo sapiens


      <400> 839
 Met Trp Asp Pro Arg Ala Ala Arg Met Asp Leu Thr Ala Tyr Ala Glu
   1               5                  10                  15    
 Leu Leu Lys Glu Ser Gly Asn Gln Val Leu Lys Asn Gly Asn Phe Ser
              20                  25                  30        
 Leu Ala Ile Arg Lys Tyr Asp Glu Ala Ile Gln Ile Leu Leu Gln Leu
          35                  40                  45            
 Tyr Gln Trp Gly Val Pro Pro Arg Asp Leu Ala Val Leu Leu Cys Asn
      50                  55                  60                
 Lys Ser Asn Ala Phe Phe Ser Leu Gly Lys Trp Asn Glu Ala Phe Val
  65                  70                  75                  80
 Ala Ala Lys Glu Cys Leu Gln Trp Asp Pro Thr Tyr Val Lys Gly Tyr
                  85                  90                  95    
 Tyr Arg Ala Gly Tyr Ser Leu Leu Arg Leu His Gln Pro Tyr Glu Ala
             100                 105                 110        
 Ala Arg Met Phe Phe Glu Gly Leu Arg Leu Val Gln Arg Ser Gln Asp
         115                 120                 125            
 Gln Ala Pro Val Ala Asp Phe Leu Val Gly Val Phe Thr Thr Val Leu
     130                 135                 140                
 Ala Trp Gln Lys Ser Met His Glu Arg Thr Val His Arg Ser Lys Leu
 145                 150                 155                 160
 Ala Ile Trp Leu Thr Arg
                 165    



      <210> 840
      <211> 1781
      <212> PRT
      <213> Homo sapiens


      <400> 840
 Met Gly Asn Ser Asp Ser Gln Tyr Thr Leu Gln Gly Ser Lys Asn His
   1               5                  10                  15    
 Ser Asn Thr Ile Thr Gly Ala Lys Gln Ile Pro Cys Ser Leu Lys Ile
              20                  25                  30        
 Arg Gly Ile His Ala Lys Glu Glu Lys Ser Leu His Gly Trp Gly His
          35                  40                  45            
 Gly Ser Asn Gly Ala Gly Tyr Lys Ser Arg Ser Leu Ala Arg Ser Cys
      50                  55                  60                
 Leu Ser His Phe Lys Ser Asn Gln Pro Tyr Ala Ser Arg Leu Gly Gly
  65                  70                  75                  80
 Pro Thr Cys Lys Val Ser Arg Gly Val Ala Tyr Ser Thr His Arg Thr
                  85                  90                  95    
 Asn Ala Pro Gly Lys Asp Phe Gln Gly Ile Ser Ala Ala Phe Ser Thr
             100                 105                 110        
 Glu Asn Gly Phe His Ser Val Gly His Glu Leu Ala Asp Asn His Ile
         115                 120                 125            
 Thr Ser Arg Asp Cys Asn Gly His Leu Leu Asn Cys Tyr Gly Arg Asn
     130                 135                 140                
 Glu Ser Ile Ala Ser Thr Pro Pro Gly Glu Asp Arg Lys Ser Pro Arg
 145                 150                 155                 160
 Val Leu Ile Lys Thr Leu Gly Lys Leu Asp Gly Cys Leu Arg Val Glu
                 165                 170                 175    
 Phe His Asn Gly Gly Asn Pro Ser Lys Val Pro Ala Glu Asp Cys Ser
             180                 185                 190        
 Glu Pro Val Gln Leu Leu Arg Tyr Ser Pro Thr Leu Ala Ser Glu Thr
         195                 200                 205            
 Ser Pro Val Pro Glu Ala Arg Arg Gly Ser Ser Ala Asp Ser Leu Pro
     210                 215                 220                
 Ser His Arg Pro Ser Pro Thr Asp Ser Arg Leu Arg Ser Ser Lys Gly
 225                 230                 235                 240
 Ser Ser Leu Ser Ser Glu Ser Ser Trp Tyr Asp Ser Pro Trp Gly Asn
                 245                 250                 255    
 Ala Gly Glu Leu Ser Glu Ala Glu Gly Ser Phe Leu Ala Pro Gly Met
             260                 265                 270        
 Pro Asp Pro Ser Leu His Ala Ser Phe Pro Pro Gly Asp Ala Lys Lys
         275                 280                 285            
 Pro Phe Asn Gln Ser Ser Ser Leu Ser Ser Leu Arg Glu Leu Tyr Lys
     290                 295                 300                
 Asp Ala Asn Leu Gly Ser Leu Ser Pro Ser Gly Ile Arg Leu Ser Asp
 305                 310                 315                 320
 Glu Tyr Met Gly Thr His Ala Ser Leu Ser Asn Arg Val Ser Phe Ala
                 325                 330                 335    
 Ser Asp Ile Asp Val Pro Ser Arg Val Ala His Gly Asp Pro Ile Gln
             340                 345                 350        
 Tyr Ser Ser Phe Thr Leu Pro Cys Arg Lys Pro Lys Ala Phe Val Glu
         355                 360                 365            
 Asp Thr Ala Lys Lys Asp Ser Leu Lys Ala Arg Met Arg Arg Ile Ser
     370                 375                 380                
 Asp Trp Thr Gly Ser Leu Ser Arg Lys Lys Arg Lys Leu Gln Glu Pro
 385                 390                 395                 400
 Arg Ser Lys Glu Gly Ser Asp Tyr Phe Asp Ser Arg Ser Asp Gly Leu
                 405                 410                 415    
 Asn Thr Asp Val Gln Gly Ser Ser Gln Ala Ser Ala Phe Leu Trp Ser
             420                 425                 430        
 Gly Gly Ser Thr Gln Ile Leu Ser Gln Arg Ser Glu Ser Thr His Ala
         435                 440                 445            
 Ile Gly Ser Asp Pro Leu Arg Gln Asn Ile Tyr Glu Asn Phe Met Arg
     450                 455                 460                
 Glu Leu Glu Met Ser Arg Thr Asn Thr Glu Asn Ile Glu Thr Ser Thr
 465                 470                 475                 480
 Glu Thr Ala Glu Ser Ser Ser Glu Ser Leu Ser Ser Leu Glu Gln Leu
                 485                 490                 495    
 Asp Leu Leu Phe Glu Lys Glu Gln Gly Val Val Arg Lys Ala Gly Trp
             500                 505                 510        
 Leu Phe Phe Lys Pro Leu Val Thr Val Gln Lys Glu Arg Lys Leu Glu
         515                 520                 525            
 Leu Val Ala Arg Arg Lys Trp Lys Gln Tyr Trp Val Thr Leu Lys Gly
     530                 535                 540                
 Glu Ser Arg Asn Ile Cys Lys Tyr Tyr Val Cys Asn Val Gln Cys Pro
 545                 550                 555                 560
 Leu Asn Tyr Pro Phe Leu Ala Phe Leu Cys Pro Leu Ser Asn Ser Trp
                 565                 570                 575    
 Ser Pro Ala Ser Pro Thr Val Glu Gly Arg His His Ala Phe Val Thr
             580                 585                 590        
 Thr Ser Pro Ser Gly Thr Ser Gly Cys Thr Leu Leu Phe Tyr Glu Thr
         595                 600                 605            
 Tyr Gly Lys Asn Ser Met Asp Gln Ser Ser Ala Pro Arg Cys Ala Leu
     610                 615                 620                
 Phe Ala Glu Asp Ser Ile Val Gln Ser Val Pro Glu His Pro Lys Lys
 625                 630                 635                 640
 Glu Asn Val Phe Cys Leu Ser Asn Ser Phe Gly Asp Val Tyr Leu Phe
                 645                 650                 655    
 Gln Ala Thr Ser Gln Thr Asp Leu Glu Asn Trp Val Thr Ala Val His
             660                 665                 670        
 Ser Ala Cys Ala Ser Leu Phe Ala Lys Lys His Gly Lys Glu Asp Thr
         675                 680                 685            
 Leu Arg Leu Leu Lys Asn Gln Thr Lys Asn Leu Leu Gln Lys Ile Asp
     690                 695                 700                
 Met Asp Ser Lys Met Lys Lys Met Ala Glu Leu Gln Leu Ser Val Val
 705                 710                 715                 720
 Ser Asp Pro Lys Asn Arg Lys Ala Ile Glu Asn Gln Ile Gln Gln Trp
                 725                 730                 735    
 Glu Gln Asn Leu Glu Lys Phe His Met Asp Leu Phe Arg Met Arg Cys
             740                 745                 750        
 Tyr Leu Ala Ser Leu Gln Gly Gly Glu Leu Pro Asn Pro Lys Ser Leu
         755                 760                 765            
 Leu Ala Ala Ala Ser Arg Pro Ser Lys Leu Ala Leu Gly Arg Leu Gly
     770                 775                 780                
 Ile Leu Ser Val Ser Ser Phe His Ala Leu Val Cys Ser Arg Asp Asp
 785                 790                 795                 800
 Ser Ala Leu Arg Lys Arg Thr Leu Ser Leu Thr Gln Arg Gly Arg Asn
                 805                 810                 815    
 Lys Lys Gly Ile Phe Ser Ser Leu Lys Gly Leu Asp Thr Leu Ala Arg
             820                 825                 830        
 Lys Gly Lys Glu Lys Arg Pro Ser Ile Thr Gln Ile Phe Asp Ser Ser
         835                 840                 845            
 Gly Ser His Gly Phe Ser Gly Thr Gln Leu Pro Gln Asn Ser Ser Asn
     850                 855                 860                
 Ser Ser Glu Val Asp Glu Leu Leu His Ile Tyr Gly Ser Thr Val Asp
 865                 870                 875                 880
 Gly Val Pro Arg Asp Asn Thr Trp Glu Ile Gln Thr Tyr Val His Phe
                 885                 890                 895    
 Gln Asp Asn His Gly Val Thr Val Gly Ile Lys Pro Glu His Arg Val
             900                 905                 910        
 Glu Asp Ile Leu Thr Leu Ala Cys Lys Met Arg Gln Leu Glu Pro Ser
         915                 920                 925            
 His Tyr Gly Leu Gln Leu Arg Lys Leu Val Asp Asp Asn Val Glu Tyr
     930                 935                 940                
 Cys Ile Pro Ala Pro Tyr Glu Tyr Met Gln Gln Gln Val Tyr Asp Glu
 945                 950                 955                 960
 Ile Glu Val Phe Pro Leu Asn Val Tyr Asp Val Gln Leu Thr Lys Thr
                 965                 970                 975    
 Gly Ser Val Cys Asp Phe Gly Phe Ala Val Thr Ala Gln Val Asp Glu
             980                 985                 990        
 Arg Gln His Leu Ser Arg Ile Phe Ile Ser Asp Val Leu Pro Asp Gly
         995                1000                1005            
 Leu Ala Tyr Gly Glu Gly Leu Arg Lys Gly Asn Glu Ile Met Thr Leu
    1010                1015                1020                
 Asn Gly Glu Ala Val Ser Asp Leu Asp Leu Lys Gln Met Glu Ala Leu
1025                1030                1035                1040
 Phe Ser Glu Lys Ser Val Gly Leu Thr Leu Ile Ala Arg Pro Pro Asp
                1045                1050                1055    
 Thr Lys Ala Thr Leu Cys Thr Ser Trp Ser Asp Ser Asp Leu Phe Ser
            1060                1065                1070        
 Arg Asp Gln Lys Ser Leu Leu Pro Pro Pro Asn Gln Ser Gln Leu Leu
        1075                1080                1085            
 Glu Glu Phe Leu Asp Asn Phe Lys Lys Asn Thr Ala Asn Asp Phe Ser
    1090                1095                1100                
 Asn Val Pro Asp Ile Thr Thr Gly Leu Lys Arg Ser Gln Thr Asp Gly
1105                1110                1115                1120
 Thr Leu Asp Gln Val Ser His Arg Glu Lys Met Glu Gln Thr Phe Arg
                1125                1130                1135    
 Ser Ala Glu Gln Ile Thr Ala Leu Cys Arg Ser Phe Asn Asp Ser Gln
            1140                1145                1150        
 Ala Asn Gly Met Glu Gly Pro Arg Glu Asn Gln Asp Pro Pro Pro Arg
        1155                1160                1165            
 Pro Leu Ala Arg His Leu Ser Asp Ala Asp Arg Leu Arg Lys Val Ile
    1170                1175                1180                
 Gln Glu Leu Val Asp Thr Glu Lys Ser Tyr Val Lys Asp Leu Ser Cys
1185                1190                1195                1200
 Leu Phe Glu Leu Tyr Leu Glu Pro Leu Gln Asn Glu Thr Phe Leu Thr
                1205                1210                1215    
 Gln Asp Glu Met Glu Ser Leu Phe Gly Ser Leu Pro Glu Met Leu Glu
            1220                1225                1230        
 Phe Gln Lys Val Phe Leu Glu Thr Leu Glu Asp Gly Ile Ser Ala Ser
        1235                1240                1245            
 Ser Asp Phe Asn Thr Leu Glu Thr Pro Ser Gln Phe Arg Lys Leu Leu
    1250                1255                1260                
 Phe Ser Leu Gly Gly Ser Phe Leu Tyr Tyr Ala Asp His Phe Lys Leu
1265                1270                1275                1280
 Tyr Ser Gly Phe Cys Ala Asn His Ile Lys Val Gln Lys Val Leu Glu
                1285                1290                1295    
 Arg Ala Lys Thr Asp Lys Ala Phe Lys Ala Phe Leu Asp Ala Arg Asn
            1300                1305                1310        
 Pro Thr Lys Gln His Ser Ser Thr Leu Glu Ser Tyr Leu Ile Lys Pro
        1315                1320                1325            
 Val Gln Arg Val Leu Lys Tyr Pro Leu Leu Leu Lys Glu Leu Val Ser
    1330                1335                1340                
 Leu Thr Asp Gln Glu Ser Glu Glu His Tyr His Leu Thr Glu Ala Leu
1345                1350                1355                1360
 Lys Ala Met Glu Lys Val Ala Ser His Ile Asn Glu Met Gln Lys Ile
                1365                1370                1375    
 Tyr Glu Asp Tyr Gly Thr Val Phe Asp Gln Leu Val Ala Glu Gln Ser
            1380                1385                1390        
 Gly Thr Glu Lys Glu Val Thr Glu Leu Ser Met Gly Glu Leu Leu Met
        1395                1400                1405            
 His Ser Thr Val Ser Trp Leu Asn Pro Phe Leu Ser Leu Gly Lys Ala
    1410                1415                1420                
 Arg Lys Asp Leu Glu Leu Thr Val Phe Val Phe Lys Arg Ala Val Ile
1425                1430                1435                1440
 Leu Val Tyr Lys Glu Asn Cys Lys Leu Lys Lys Lys Leu Pro Ser Asn
                1445                1450                1455    
 Ser Arg Pro Ala His Asn Ser Thr Asp Leu Asp Pro Phe Lys Phe Arg
            1460                1465                1470        
 Trp Leu Ile Pro Ile Ser Ala Leu Gln Val Arg Leu Gly Asn Pro Ala
        1475                1480                1485            
 Gly Thr Glu Asn Asn Ser Ile Trp Glu Leu Ile His Thr Lys Ser Glu
    1490                1495                1500                
 Ile Glu Gly Arg Pro Glu Thr Ile Phe Gln Leu Cys Cys Ser Asp Ser
1505                1510                1515                1520
 Glu Ser Lys Thr Asn Ile Val Lys Val Ile Arg Ser Ile Leu Arg Glu
                1525                1530                1535    
 Asn Phe Arg Arg His Ile Lys Cys Glu Leu Pro Leu Glu Lys Thr Cys
            1540                1545                1550        
 Lys Asp Arg Leu Val Pro Leu Lys Asn Arg Val Pro Val Ser Ala Lys
        1555                1560                1565            
 Leu Ala Ser Ser Arg Ser Leu Lys Val Leu Lys Asn Ser Ser Ser Asn
    1570                1575                1580                
 Glu Trp Thr Gly Glu Thr Gly Lys Gly Thr Leu Leu Asp Ser Asp Glu
1585                1590                1595                1600
 Gly Ser Leu Ser Ser Gly Thr Gln Ser Ser Gly Cys Pro Thr Ala Glu
                1605                1610                1615    
 Gly Arg Gln Asp Ser Lys Ser Thr Ser Pro Gly Lys Tyr Pro His Pro
            1620                1625                1630        
 Gly Leu Ala Asp Phe Ala Asp Asn Leu Ile Lys Glu Ser Asp Ile Leu
        1635                1640                1645            
 Ser Asp Glu Asp Asp Asp His Arg Gln Thr Val Lys Gln Gly Ser Pro
    1650                1655                1660                
 Thr Lys Asp Ile Glu Ile Gln Phe Gln Arg Leu Arg Ile Ser Glu Asp
1665                1670                1675                1680
 Pro Asp Val His Pro Glu Ala Glu Gln Gln Pro Gly Pro Glu Ser Gly
                1685                1690                1695    
 Glu Gly Gln Lys Gly Gly Glu Gln Pro Lys Leu Val Arg Gly His Phe
            1700                1705                1710        
 Cys Pro Ile Lys Arg Lys Ala Asn Ser Thr Lys Arg Asp Arg Gly Thr
        1715                1720                1725            
 Leu Leu Lys Ala Gln Ile Arg His Gln Ser Leu Asp Ser Gln Ser Glu
    1730                1735                1740                
 Asn Ala Thr Ile Asp Leu Asn Ser Val Leu Glu Arg Glu Phe Ser Val
1745                1750                1755                1760
 Gln Ser Leu Thr Ser Val Val Ser Glu Glu Cys Phe Tyr Glu Thr Glu
                1765                1770                1775    
 Ser His Gly Lys Ser
            1780    



      <210> 841
      <211> 315
      <212> PRT
      <213> Homo sapiens


      <400> 841
 Met Ala Ser Gln Gly Pro Gln Ala Trp Asp Val Thr Thr Thr Asn Cys
   1               5                  10                  15    
 Ser Ala Asn Ile Asn Leu Thr His Gln Pro Trp Phe Gln Val Leu Glu
              20                  25                  30        
 Pro Gln Phe Arg Gln Phe Leu Phe Tyr Arg His Cys Arg Tyr Phe Pro
          35                  40                  45            
 Met Leu Leu Asn His Pro Glu Lys Cys Arg Gly Asp Val Tyr Leu Leu
      50                  55                  60                
 Val Val Val Lys Ser Val Ile Thr Gln His Asp Arg Arg Glu Ala Ile
  65                  70                  75                  80
 Arg Gln Thr Trp Gly Arg Glu Arg Gln Ser Ala Gly Gly Gly Arg Gly
                  85                  90                  95    
 Ala Val Arg Thr Leu Phe Leu Leu Gly Thr Ala Ser Lys Gln Glu Glu
             100                 105                 110        
 Arg Thr His Tyr Gln Gln Leu Leu Ala Tyr Glu Asp Arg Leu Tyr Gly
         115                 120                 125            
 Asp Ile Leu Gln Trp Gly Phe Leu Asp Thr Phe Phe Asn Leu Thr Leu
     130                 135                 140                
 Lys Glu Ile His Phe Leu Lys Trp Leu Asp Ile Tyr Cys Pro His Val
 145                 150                 155                 160
 Pro Phe Ile Phe Lys Gly Asp Asp Asp Val Phe Val Asn Pro Thr Asn
                 165                 170                 175    
 Leu Phe Val Gly Asp Val Leu Gln His Ala Arg Pro Ile Arg Arg Lys
             180                 185                 190        
 Asp Asn Lys Tyr Tyr Ile Pro Gly Ala Leu Tyr Gly Lys Ala Ser Tyr
         195                 200                 205            
 Pro Pro Tyr Ala Gly Gly Gly Gly Phe Leu Met Ala Gly Ser Leu Ala
     210                 215                 220                
 Arg Arg Leu His His Ala Cys Asp Thr Leu Glu Leu Tyr Pro Ile Asp
 225                 230                 235                 240
 Asp Val Phe Leu Gly Met Cys Leu Glu Val Leu Gly Val Gln Pro Thr
                 245                 250                 255    
 Ala His Glu Gly Phe Lys Thr Phe Gly Ile Ser Arg Asn Arg Asn Ser
             260                 265                 270        
 Arg Met Asn Lys Glu Pro Cys Phe Phe Arg Ala Met Leu Val Val His
         275                 280                 285            
 Lys Leu Leu Pro Pro Glu Leu Leu Ala Met Trp Gly Leu Val His Ser
     290                 295                 300                
 Asn Leu Thr Cys Ser Arg Lys Leu Gln Val Leu
 305                 310                 315



      <210> 842
      <211> 367
      <212> PRT
      <213> Homo sapiens


      <400> 842
 Met Gly Arg Gly Gly Glu Gly Gly Cys Gln Arg Asp Gly Gly Pro Gly
   1               5                  10                  15    
 Pro Gln Cys Pro His Pro Phe Cys Ser Pro Ala His Pro Gly Pro Pro
              20                  25                  30        
 Ser Gly Pro Ile His Pro Thr Leu Ser Leu Cys Gln Val Gln Val Gln
          35                  40                  45            
 Glu Gly Thr Trp Thr Gln Thr Ser Gly Asp Ala Gln Ser Asp Gly Gly
      50                  55                  60                
 Tyr Met Asp Pro Asp Ser Gly Ser Ser Gln Ser Asp Gly Gly Asp Ile
  65                  70                  75                  80
 Asp Pro Asp Ser Gly Ile Ser Gln Ser Asp Gly Gly Asp Met Val Pro
                  85                  90                  95    
 Asp Ser Gly Ser Ser Gln Ser Asp Gly Gly Asp Met Leu Pro Asp Ser
             100                 105                 110        
 Gly Ser Ser Gln Ser Asp Gly Gly Asp Met Val Pro Asp Ser Gly Ser
         115                 120                 125            
 Ser Gln Ser Asp Gly Gly Asp Met Val Pro Asp Ser Gly Ser Ser Gln
     130                 135                 140                
 Ser Asp Gly Gly Asp Met Val Pro Asp Ser Gly Ser Ser Gln Ser Asp
 145                 150                 155                 160
 Gly Gly Asp Ile Asp Pro Asp Ser Gly Ser Ser Gln Ser Asp Gly Gly
                 165                 170                 175    
 Asp Met Asp His Ala Ser Gly Ser Ser Arg Ser Asp Gly Gly Asp Ile
             180                 185                 190        
 Asp Pro Asp Ser Gly Ser Ser Arg Ser Asp Gly Gly Asp Met Val Pro
         195                 200                 205            
 Asp Ser Gly Ser Ser Gln Ser Asp Glu Gly Asp Met Val Pro Asp Ser
     210                 215                 220                
 Gly Ser Ser Gln Ser Asp Glu Gly Asp Met Val Pro Asp Ser Gly Ser
 225                 230                 235                 240
 Ser Arg Ser Asp Gly Gly Asp Ile Asp Pro Asp Ser Gly Ser Ser Gln
                 245                 250                 255    
 Ser Asp Gly Gly Asp Met Val Pro Asp Ser Gly Ser Ser Gln Ser Asp
             260                 265                 270        
 Gly Gly Asn Met Val Pro Asp Ser Gly Ser Ser Gln Ser Asp Gly Gly
         275                 280                 285            
 Asp Met Asp Pro His Ser Trp Ser Ser Gln Ser Asp Glu Gly Asp Ile
     290                 295                 300                
 Val Pro Asp Ser Gly Ser Ser Gln Ser Asp Gly Gly Asp Met Asp His
 305                 310                 315                 320
 Ala Ser Gly Ser Ser Gln Ser Asp Glu Gly Asp Val Val Ser Ala Ser
                 325                 330                 335    
 Gly Ser Ser Gln Ser Asp Gly Gly Asn Met Val Tyr Asn Ser Gly Ser
             340                 345                 350        
 Ser Gln Ser Asp Gly Gly Asp Leu Asp Leu Asp Ser Gly Ser Ser
         355                 360                 365        



      <210> 843
      <211> 116
      <212> PRT
      <213> Homo sapiens


      <400> 843
 Met Gly Thr Gly Leu Arg Ser Gln Ser Leu Arg Glu Pro Arg Pro Ser
   1               5                  10                  15    
 Tyr Gly Lys Leu Gln Glu Pro Trp Gly Arg Pro Gln Glu Gly Gln Leu
              20                  25                  30        
 Arg Arg Ala Leu Ser Leu Arg Gln Gly Gln Glu Lys Ser Arg Ser Gln
          35                  40                  45            
 Gly Leu Glu Arg Gly Thr Glu Gly Pro Asp Ala Thr Ala Gln Glu Arg
      50                  55                  60                
 Val Pro Gly Ser Leu Gly Asp Thr Glu Gln Leu Ile Gln Ala Gln Arg
  65                  70                  75                  80
 Arg Gly Ser Arg Trp Trp Leu Arg Arg Tyr Gln Gln Gln Val Arg Arg
                  85                  90                  95    
 Arg Trp Glu Ser Phe Val Ala Ile Phe Pro Ser Val Thr Leu Ser Gln
             100                 105                 110        
 Pro Ala Ser Pro
         115    



      <210> 844
      <211> 260
      <212> PRT
      <213> Homo sapiens


      <400> 844
 Met Glu Lys Phe Asn Thr Ile Ser Ala Ser Lys Cys Asn Lys Glu Thr
   1               5                  10                  15    
 Val Ala Met Lys Glu Lys Cys Lys Phe Gly Met Thr Ser Thr Ile Pro
              20                  25                  30        
 Ser Gly His Val Trp Arg Asn Thr Trp Asn Pro Val Ser Cys Ser Leu
          35                  40                  45            
 Ala Thr Val Lys Met Lys Glu Cys Leu Arg Gly Lys Leu Ile Tyr Leu
      50                  55                  60                
 Met Gly Asp Ser Thr Ile Arg Gln Trp Met Glu Tyr Phe Lys Ala Ser
  65                  70                  75                  80
 Ile Asn Thr Leu Lys Ser Val Asp Leu His Glu Ser Gly Lys Leu Gln
                  85                  90                  95    
 His Gln Leu Ala Val Asp Leu Asp Arg Asn Ile Asn Ile Gln Trp Gln
             100                 105                 110        
 Lys His Cys Tyr Pro Leu Ile Gly Ser Met Thr Tyr Ser Val Lys Glu
         115                 120                 125            
 Met Glu Tyr Leu Thr Arg Ala Ile Asp Arg Thr Gly Gly Glu Lys Asn
     130                 135                 140                
 Thr Val Ile Val Ile Ser Leu Gly Gln His Phe Arg Pro Phe Pro Ile
 145                 150                 155                 160
 Asp Val Phe Ile Arg Arg Val Leu Asn Val His Lys Ala Ile Gln His
                 165                 170                 175    
 Leu Leu Leu Arg Ser Pro Asp Thr Met Val Ile Ile Lys Thr Glu Asn
             180                 185                 190        
 Ile Arg Glu Met Tyr Asn Asp Ala Glu Arg Phe Ser Asp Phe His Gly
         195                 200                 205            
 Tyr Ile Gln Tyr Leu Ile Ile Lys Asp Ile Phe Gln Asp Leu Ser Val
     210                 215                 220                
 Ser Ile Ile Asp Ala Trp Asp Ile Thr Ile Ala Tyr Gly Thr Asn Asn
 225                 230                 235                 240
 Val His Pro Pro Gln His Val Val Gly Asn Gln Ile Asn Ile Leu Leu
                 245                 250                 255    
 Asn Tyr Ile Cys
             260



      <210> 845
      <211> 99
      <212> PRT
      <213> Homo sapiens


      <400> 845
 Met Gly Leu Gly Gln Arg Met Phe Leu Ala His Thr Ser Val Glu Ser
   1               5                  10                  15    
 Phe Thr Ala Pro Ala Ser Phe Glu Lys Asn Arg Cys Pro Arg Met Gly
              20                  25                  30        
 Gly Arg Asp Ile His Thr Met Lys Ala Arg Val Pro Gln His His Lys
          35                  40                  45            
 Leu Glu Lys Ile Leu Glu Val Gly Ile Arg Lys Lys Ile Glu His Asp
      50                  55                  60                
 Ala Val Met Lys Ala Ser Ser Ser Leu Pro Lys Lys Leu Ala Leu Leu
  65                  70                  75                  80
 Lys Ala Pro Ala Lys Lys Lys Gly Ala Asp Ala Ala Thr Ser Ser Lys
                  85                  90                  95    
 Thr Pro Phe
            



      <210> 846
      <211> 319
      <212> PRT
      <213> Homo sapiens


      <400> 846
 Met Gln Leu Phe Val Arg Ala Gln Glu Leu His Thr Phe Glu Val Thr
   1               5                  10                  15    
 Gly Gln Glu Thr Val Ala Gln Ile Lys Ala His Val Ala Ser Leu Glu
              20                  25                  30        
 Gly Ile Ala Pro Glu Asp Gln Val Val Leu Leu Ala Gly Ala Pro Leu
          35                  40                  45            
 Glu Asp Glu Ala Thr Leu Gly Gln Cys Gly Val Glu Ala Leu Thr Thr
      50                  55                  60                
 Leu Glu Val Ala Gly Arg Met Leu Gly Gly Lys Val His Gly Ser Leu
  65                  70                  75                  80
 Ala Arg Ala Gly Thr Gly Arg Ala Lys Arg Arg Met Gln Tyr Asn Arg
                  85                  90                  95    
 Arg Phe Val Asn Val Val Pro Thr Phe Gly Lys Lys Lys Gly Thr Thr
             100                 105                 110        
 Phe Thr Lys Ile Phe Val Gly Gly Leu Pro Tyr His Thr Thr Asp Ala
         115                 120                 125            
 Ser Leu Arg Lys Tyr Phe Glu Gly Phe Gly Asp Ile Glu Glu Ala Val
     130                 135                 140                
 Val Ile Thr Asp Arg Gln Thr Gly Lys Ser Arg Gly Tyr Gly Phe Val
 145                 150                 155                 160
 Thr Met Ala Asp Arg Ala Ala Ala Glu Arg Ala Cys Lys Asp Pro Asn
                 165                 170                 175    
 Pro Ile Ile Asp Gly Arg Lys Ala Asn Val Asn Leu Ala Tyr Leu Gly
             180                 185                 190        
 Ala Lys Pro Arg Ser Leu Gln Thr Gly Phe Ala Ile Gly Val Gln Gln
         195                 200                 205            
 Leu His Pro Thr Leu Ile Gln Arg Thr Tyr Gly Leu Thr Pro His Tyr
     210                 215                 220                
 Ile Tyr Pro Pro Ala Ile Val Gln Pro Ser Val Val Ile Pro Ala Ala
 225                 230                 235                 240
 Pro Val Pro Ser Leu Ser Ser Pro Tyr Ile Glu Tyr Thr Pro Ala Ser
                 245                 250                 255    
 Pro Ala Tyr Ala Gln Tyr Pro Pro Ala Thr Tyr Asp Gln Tyr Pro Tyr
             260                 265                 270        
 Ala Ala Ser Pro Ala Thr Ala Ala Ser Phe Val Gly Tyr Ser Tyr Pro
         275                 280                 285            
 Ala Ala Val Pro Gln Ala Leu Ser Ala Ala Ala Pro Ala Gly Thr Thr
     290                 295                 300                
 Phe Val Gln Tyr Gln Ala Pro Gln Leu Gln Pro Asp Arg Met Gln
 305                 310                 315                



      <210> 847
      <211> 267
      <212> PRT
      <213> Homo sapiens


      <400> 847
 Met Leu Gly Gly Lys Val His Gly Ser Leu Ala Arg Ala Gly Lys Val
   1               5                  10                  15    
 Arg Gly Gln Thr Pro Lys Val Ala Lys Gln Glu Lys Lys Lys Lys Lys
              20                  25                  30        
 Thr Gly Arg Ala Lys Arg Arg Met Gln Tyr Asn Arg Arg Phe Val Asn
          35                  40                  45            
 Val Val Pro Thr Phe Gly Lys Lys Lys Gly Thr Thr Phe Thr Lys Ile
      50                  55                  60                
 Phe Val Gly Gly Leu Pro Tyr His Thr Thr Asp Ala Ser Leu Arg Lys
  65                  70                  75                  80
 Tyr Phe Glu Gly Phe Gly Asp Ile Glu Glu Ala Val Val Ile Thr Asp
                  85                  90                  95    
 Arg Gln Thr Gly Lys Ser Arg Gly Tyr Gly Phe Val Thr Met Ala Asp
             100                 105                 110        
 Arg Ala Ala Ala Glu Arg Ala Cys Lys Asp Pro Asn Pro Ile Ile Asp
         115                 120                 125            
 Gly Arg Lys Ala Asn Val Asn Leu Ala Tyr Leu Gly Ala Lys Pro Arg
     130                 135                 140                
 Ser Leu Gln Thr Gly Phe Ala Ile Gly Val Gln Gln Leu His Pro Thr
 145                 150                 155                 160
 Leu Ile Gln Arg Thr Tyr Gly Leu Thr Pro His Tyr Ile Tyr Pro Pro
                 165                 170                 175    
 Ala Ile Val Gln Pro Ser Val Val Ile Pro Ala Ala Pro Val Pro Ser
             180                 185                 190        
 Leu Ser Ser Pro Tyr Ile Glu Tyr Thr Pro Ala Ser Pro Ala Tyr Ala
         195                 200                 205            
 Gln Tyr Pro Pro Ala Thr Tyr Asp Gln Tyr Pro Tyr Ala Ala Ser Pro
     210                 215                 220                
 Ala Thr Ala Ala Ser Phe Val Gly Tyr Ser Tyr Pro Ala Ala Val Pro
 225                 230                 235                 240
 Gln Ala Leu Ser Ala Ala Ala Pro Ala Gly Thr Thr Phe Val Gln Tyr
                 245                 250                 255    
 Gln Ala Pro Gln Leu Gln Pro Asp Arg Met Gln
             260                 265        



      <210> 848
      <211> 172
      <212> PRT
      <213> Homo sapiens


      <400> 848
 Met Gly Lys Arg Asp Asn Arg Val Ala Tyr Met Asn Pro Ile Ala Met
   1               5                  10                  15    
 Ala Arg Trp Arg Gly Pro Thr Gln Ser Val Gly Pro Thr Ile Gln Asp
              20                  25                  30        
 Tyr Leu Asn Arg Pro Arg Pro Thr Trp Glu Glu Val Lys Lys Gln Leu
          35                  40                  45            
 Glu Asn Lys Lys Lys Gly Ser Lys Ala Leu Ala Glu Phe Glu Glu Lys
      50                  55                  60                
 Met Asn Glu Asn Trp Lys Lys Glu Leu Glu Lys Ser Arg Glu Lys Leu
  65                  70                  75                  80
 Leu Ser Gly Asn Glu Ser Ser Ser Lys Lys Arg Glu Arg Lys Lys Lys
                  85                  90                  95    
 Arg Lys Lys Lys Ser Cys Arg Ser Ser Ser Ser Ser Ser Ser Ser Asp
             100                 105                 110        
 Ser Ser Ser Ser Ser Ser Asp Ser Glu Asp Glu Glu Lys Lys Gln Gly
         115                 120                 125            
 Lys Arg Arg Lys Lys Lys Lys Asn Arg Ser Tyr Lys Ser Ser Gln Ser
     130                 135                 140                
 Ser Thr His Glu Ser Glu Ser Glu Ser Lys Glu Ser Val Lys Arg Lys
 145                 150                 155                 160
 Arg Ser Gln Arg Met Lys Gln Arg Lys Lys Arg Met
                 165                 170        



      <210> 849
      <211> 360
      <212> PRT
      <213> Homo sapiens


      <400> 849
 Met Gln Ile Ile Arg His Ser Glu Gln Thr Leu Lys Thr Ala Leu Ile
   1               5                  10                  15    
 Ser Lys Asn Pro Val Leu Val Ser Gln Tyr Glu Lys Leu Asp Ala Gly
              20                  25                  30        
 Glu Gln Arg Leu Met Asn Glu Ala Phe Gln Pro Ala Ser Asp Leu Phe
          35                  40                  45            
 Gly Pro Ile Thr Leu His Ser Pro Ser Asp Trp Ile Thr Ser His Pro
      50                  55                  60                
 Glu Ala Pro Gln Asp Phe Glu Gln Phe Phe Ser Asp Pro Tyr Arg Lys
  65                  70                  75                  80
 Thr Pro Ser Pro Asn Lys Arg Ser Ile Tyr Ile Gln Ser Ile Gly Ser
                  85                  90                  95    
 Leu Gly Asn Thr Arg Ile Ile Ser Glu Glu Tyr Ile Lys Trp Leu Thr
             100                 105                 110        
 Gly Tyr Cys Lys Ala Tyr Phe Tyr Gly Leu Arg Val Lys Leu Leu Glu
         115                 120                 125            
 Pro Val Pro Val Ser Val Thr Arg Cys Ser Phe Arg Val Asn Glu Asn
     130                 135                 140                
 Thr His Asn Leu Gln Ile His Ala Gly Asp Ile Leu Lys Phe Leu Lys
 145                 150                 155                 160
 Lys Lys Lys Pro Glu Asp Ala Phe Cys Val Val Gly Ile Thr Met Ile
                 165                 170                 175    
 Asp Leu Tyr Pro Arg Asp Ser Trp Asn Phe Val Phe Gly Gln Ala Ser
             180                 185                 190        
 Leu Thr Asp Gly Val Gly Ile Phe Ser Phe Ala Arg Tyr Gly Ser Asp
         195                 200                 205            
 Phe Tyr Ser Met His Tyr Lys Gly Lys Val Lys Lys Leu Lys Lys Thr
     210                 215                 220                
 Ser Ser Ser Asp Tyr Ser Ile Phe Asp Asn Tyr Tyr Ile Pro Glu Ile
 225                 230                 235                 240
 Thr Ser Val Leu Leu Leu Arg Ser Cys Lys Thr Leu Thr His Glu Ile
                 245                 250                 255    
 Gly His Ile Phe Gly Leu Arg His Cys Gln Trp Leu Ala Cys Leu Met
             260                 265                 270        
 Gln Gly Ser Asn His Leu Glu Glu Ala Asp Arg Arg Pro Leu Asn Leu
         275                 280                 285            
 Cys Pro Ile Cys Leu His Lys Leu Gln Cys Ala Val Gly Phe Ser Ile
     290                 295                 300                
 Val Glu Arg Tyr Lys Ala Leu Val Arg Trp Ile Asp Asp Glu Ser Ser
 305                 310                 315                 320
 Asp Thr Pro Gly Ala Thr Pro Glu His Ser His Glu Asp Asn Gly Asn
                 325                 330                 335    
 Leu Pro Lys Pro Val Glu Ala Phe Lys Glu Trp Lys Glu Trp Ile Ile
             340                 345                 350        
 Lys Cys Leu Ala Val Leu Gln Lys
         355                 360



      <210> 850
      <211> 1473
      <212> PRT
      <213> Homo sapiens


      <400> 850
 Met Asp Val Glu Arg Ser Val Ser Asp Leu Tyr Lys Met Lys His Ser
   1               5                  10                  15    
 Val Pro Gln Ser Leu Pro Gln Ser Asn Tyr Phe Thr Thr Leu Ser Asn
              20                  25                  30        
 Ser Val Val Asn Glu Pro Pro Arg Ser Tyr Pro Ser Lys Glu Val Ser
          35                  40                  45            
 Asn Ile Tyr Gly Asp Lys Gln Ser Asn Ala Leu Ala Ala Ala Ala Ala
      50                  55                  60                
 Asn Pro Gln Thr Leu Thr Ser Phe Ile Thr Ser Leu Ser Lys Pro Pro
  65                  70                  75                  80
 Pro Leu Ile Lys His Gln Pro Glu Ser Glu Gly Leu Val Gly Lys Ile
                  85                  90                  95    
 Pro Glu His Leu Pro His Gln Ile Ala Ser His Ser Val Thr Thr Phe
             100                 105                 110        
 Arg Asn Asp Cys Arg Ser Pro Thr His Leu Thr Val Ser Ser Thr Asn
         115                 120                 125            
 Thr Leu Arg Ser Met Pro Ala Leu His Arg Ala Pro Val Phe His Pro
     130                 135                 140                
 Pro Ile His His Ser Leu Glu Arg Lys Glu Gly Ser Tyr Ser Ser Leu
 145                 150                 155                 160
 Ser Pro Pro Thr Leu Thr Pro Val Met Pro Val Asn Ala Gly Gly Lys
                 165                 170                 175    
 Val Gln Glu Ser Gln Lys Pro Pro Thr Leu Ile Pro Glu Pro Lys Asp
             180                 185                 190        
 Ser Gln Ala Asn Phe Lys Ser Ser Ser Glu Gln Ser Leu Thr Glu Met
         195                 200                 205            
 Trp Arg Pro Asn Asn Asn Leu Ser Lys Glu Lys Thr Glu Trp His Val
     210                 215                 220                
 Glu Lys Ser Ser Gly Lys Leu Gln Ala Ala Met Ala Ser Val Ile Val
 225                 230                 235                 240
 Arg Pro Ser Ser Ser Thr Lys Thr Asp Ser Met Pro Ala Met Gln Leu
                 245                 250                 255    
 Ala Ser Lys Asp Arg Val Ser Glu Arg Ser Ser Ala Gly Ala His Lys
             260                 265                 270        
 Thr Asp Cys Leu Lys Leu Ala Glu Ala Gly Glu Thr Gly Arg Ile Ile
         275                 280                 285            
 Leu Pro Asn Val Asn Ser Asp Ser Val His Thr Lys Ser Glu Lys Asn
     290                 295                 300                
 Phe Gln Ala Val Ser Gln Gly Ser Val Pro Ser Ser Val Met Ser Ala
 305                 310                 315                 320
 Val Asn Thr Met Cys Asn Thr Lys Thr Asp Val Ile Thr Ser Ala Ala
                 325                 330                 335    
 Asp Thr Thr Ser Val Ser Ser Trp Gly Gly Ser Glu Val Ile Ser Ser
             340                 345                 350        
 Leu Ser Asn Thr Ile Leu Ala Ser Thr Ser Ser Glu Cys Val Ser Ser
         355                 360                 365            
 Lys Ser Val Ser Gln Pro Val Ala Gln Lys Gln Glu Cys Lys Val Ser
     370                 375                 380                
 Thr Thr Ala Pro Val Thr Leu Ala Ser Ser Lys Thr Gly Ser Val Val
 385                 390                 395                 400
 Gln Pro Ser Ser Gly Phe Ser Gly Thr Thr Asp Phe Ile His Leu Lys
                 405                 410                 415    
 Lys His Lys Ala Ala Leu Ala Ala Ala Gln Tyr Lys Ser Ser Asn Ala
             420                 425                 430        
 Ser Glu Thr Glu Pro Asn Ala Ile Lys Asn Gln Thr Leu Ser Ala Ser
         435                 440                 445            
 Leu Pro Leu Asp Ser Thr Val Ile Cys Ser Thr Ile Asn Lys Ala Asn
     450                 455                 460                
 Ser Val Gly Asn Gly Gln Ala Ser Gln Thr Ser Gln Pro Asn Tyr His
 465                 470                 475                 480
 Thr Lys Leu Lys Lys Ala Trp Leu Thr Arg His Ser Glu Glu Asp Lys
                 485                 490                 495    
 Asn Thr Asn Lys Met Glu Asn Ser Gly Asn Ser Val Ser Glu Ile Ile
             500                 505                 510        
 Lys Pro Cys Ser Val Asn Leu Ile Ala Ser Thr Ser Ser Asp Ile Gln
         515                 520                 525            
 Asn Ser Val Asp Ser Lys Ile Ile Val Asp Lys Tyr Val Lys Asp Asp
     530                 535                 540                
 Lys Val Asn Arg Arg Lys Ala Lys Arg Thr Tyr Glu Ser Gly Ser Glu
 545                 550                 555                 560
 Ser Gly Asp Ser Asp Glu Ser Glu Ser Lys Ser Glu Gln Arg Thr Lys
                 565                 570                 575    
 Arg Gln Pro Lys Pro Thr Tyr Lys Lys Lys Gln Asn Asp Leu Gln Lys
             580                 585                 590        
 Arg Lys Gly Glu Ile Glu Glu Asp Leu Lys Pro Asn Gly Val Leu Ser
         595                 600                 605            
 Arg Ser Ala Lys Glu Arg Ser Lys Leu Lys Leu Gln Ser Asn Ser Asn
     610                 615                 620                
 Thr Gly Ile Pro Arg Ser Val Leu Lys Asp Trp Arg Lys Val Lys Lys
 625                 630                 635                 640
 Leu Lys Gln Thr Gly Glu Ser Phe Leu Gln Asp Asp Ser Cys Cys Glu
                 645                 650                 655    
 Ile Gly Pro Asn Leu Gln Lys Cys Arg Glu Cys Arg Leu Ile Arg Ser
             660                 665                 670        
 Lys Lys Gly Glu Glu Pro Ala His Ser Pro Val Phe Cys Arg Phe Tyr
         675                 680                 685            
 Tyr Phe Arg Arg Leu Ser Phe Ser Lys Asn Gly Val Val Arg Ile Asp
     690                 695                 700                
 Gly Phe Ser Ser Pro Asp Gln Tyr Asp Asp Glu Ala Met Ser Leu Trp
 705                 710                 715                 720
 Thr His Glu Asn Phe Glu Asp Asp Glu Leu Asp Ile Glu Thr Ser Lys
                 725                 730                 735    
 Tyr Ile Leu Asp Ile Ile Gly Asp Lys Phe Cys Gln Leu Val Thr Ser
             740                 745                 750        
 Glu Lys Thr Ala Leu Ser Trp Val Lys Lys Asp Ala Lys Ile Ala Trp
         755                 760                 765            
 Lys Arg Ala Val Arg Gly Val Arg Glu Met Cys Asp Ala Cys Glu Ala
     770                 775                 780                
 Thr Leu Phe Asn Ile His Trp Val Cys Gln Lys Cys Gly Phe Val Val
 785                 790                 795                 800
 Cys Leu Asp Cys Tyr Lys Ala Lys Glu Arg Lys Ser Ser Arg Asp Lys
                 805                 810                 815    
 Glu Leu Tyr Ala Trp Met Lys Cys Val Lys Gly Gln Pro His Asp His
             820                 825                 830        
 Lys His Leu Met Pro Thr Gln Ile Ile Pro Gly Ser Val Leu Thr Asp
         835                 840                 845            
 Leu Leu Asp Ala Met His Thr Leu Arg Glu Lys Tyr Gly Ile Lys Ser
     850                 855                 860                
 His Cys His Cys Thr Asn Lys Gln Asn Leu Gln Val Gly Asn Phe Pro
 865                 870                 875                 880
 Thr Met Asn Gly Val Ser Gln Val Leu Gln Asn Val Leu Asn His Ser
                 885                 890                 895    
 Asn Lys Ile Ser Leu Cys Met Pro Glu Ser Gln Gln Gln Asn Thr Pro
             900                 905                 910        
 Pro Lys Ser Glu Lys Asn Gly Gly Ser Ser Pro Glu Ser Asp Val Gly
         915                 920                 925            
 Thr Asp Asn Lys Leu Thr Pro Pro Glu Ser Gln Ser Pro Leu His Trp
     930                 935                 940                
 Leu Ala Asp Leu Ala Glu Gln Lys Ala Arg Glu Glu Lys Lys Glu Asn
 945                 950                 955                 960
 Lys Glu Leu Thr Leu Glu Asn Gln Ile Lys Glu Glu Arg Glu Gln Asp
                 965                 970                 975    
 Asn Ser Glu Ser Pro Asn Gly Arg Thr Ser Pro Leu Val Ser Gln Asn
             980                 985                 990        
 Asn Glu Gln Gly Ser Thr Leu Arg Asp Leu Leu Thr Thr Thr Ala Gly
         995                1000                1005            
 Lys Leu Arg Val Gly Ser Thr Asp Ala Gly Ile Ala Phe Ala Pro Val
    1010                1015                1020                
 Tyr Ser Met Gly Ala Pro Ser Ser Lys Ser Gly Arg Thr Met Pro Asn
1025                1030                1035                1040
 Ile Leu Asp Asp Ile Ile Ala Ser Val Val Glu Asn Lys Ile Pro Pro
                1045                1050                1055    
 Ser Lys Thr Ser Lys Ile Asn Val Lys Pro Glu Leu Lys Glu Glu Pro
            1060                1065                1070        
 Glu Glu Ser Ile Ile Ser Ala Val Asp Glu Asn Asn Lys Leu Tyr Ser
        1075                1080                1085            
 Asp Ile Pro His Ser Trp Ile Cys Glu Lys His Ile Leu Trp Leu Lys
    1090                1095                1100                
 Asp Tyr Lys Asn Ser Ser Asn Trp Lys Leu Phe Lys Glu Cys Trp Lys
1105                1110                1115                1120
 Gln Gly Gln Pro Ala Val Val Ser Gly Val His Lys Lys Met Asn Ile
                1125                1130                1135    
 Ser Leu Trp Lys Ala Glu Ser Ile Ser Leu Asp Phe Gly Asp His Gln
            1140                1145                1150        
 Ala Asp Leu Leu Asn Cys Lys Asp Ser Ile Ile Ser Asn Ala Asn Val
        1155                1160                1165            
 Lys Glu Phe Trp Asp Gly Phe Glu Glu Val Ser Lys Arg Gln Lys Asn
    1170                1175                1180                
 Lys Ser Gly Glu Thr Val Val Leu Lys Leu Lys Asp Trp Pro Ser Gly
1185                1190                1195                1200
 Glu Asp Phe Lys Thr Met Met Pro Ala Arg Tyr Glu Asp Leu Leu Lys
                1205                1210                1215    
 Ser Leu Pro Leu Pro Glu Tyr Cys Asn Pro Glu Gly Lys Phe Asn Leu
            1220                1225                1230        
 Ala Ser His Leu Pro Gly Phe Phe Val Arg Pro Asp Leu Gly Pro Arg
        1235                1240                1245            
 Leu Cys Ser Ala Tyr Gly Val Val Ala Ala Lys Asp His Asp Ile Gly
    1250                1255                1260                
 Thr Thr Asn Leu His Ile Glu Val Ser Asp Val Val Asn Ile Leu Val
1265                1270                1275                1280
 Tyr Val Gly Ile Ala Lys Gly Asn Gly Ile Leu Ser Lys Ala Gly Ile
                1285                1290                1295    
 Leu Lys Lys Phe Glu Glu Glu Asp Leu Asp Asp Ile Leu Arg Lys Arg
            1300                1305                1310        
 Leu Lys Asp Ser Ser Glu Ile Pro Gly Ala Leu Trp His Ile Tyr Ala
        1315                1320                1325            
 Gly Lys Asp Val Asp Lys Ile Arg Glu Phe Leu Gln Lys Ile Ser Lys
    1330                1335                1340                
 Glu Gln Gly Leu Glu Val Leu Pro Glu His Asp Pro Ile Arg Asp Gln
1345                1350                1355                1360
 Ser Trp Tyr Val Asn Lys Lys Leu Arg Gln Arg Leu Leu Glu Glu Tyr
                1365                1370                1375    
 Gly Val Arg Thr Cys Thr Leu Ile Gln Phe Leu Gly Asp Ala Ile Val
            1380                1385                1390        
 Leu Pro Ala Gly Ala Leu His Gln Val Gln Asn Phe His Ser Cys Ile
        1395                1400                1405            
 Gln Val Thr Glu Asp Phe Val Ser Pro Glu His Leu Val Glu Ser Phe
    1410                1415                1420                
 His Leu Thr Gln Glu Leu Arg Leu Leu Lys Glu Glu Ile Asn Tyr Asp
1425                1430                1435                1440
 Asp Lys Leu Gln Val Lys Asn Ile Leu Tyr His Ala Val Lys Glu Met
                1445                1450                1455    
 Val Arg Ala Leu Lys Ile His Glu Asp Glu Val Glu Asp Met Glu Glu
            1460                1465                1470        
 Asn
    



      <210> 851
      <211> 220
      <212> PRT
      <213> Homo sapiens


      <400> 851
 Met Pro His Pro Ser Val Arg Gly Tyr Arg Leu Gly Ala Met Ser Leu
   1               5                  10                  15    
 Lys Pro Phe Thr Tyr Pro Phe Pro Glu Thr Arg Phe Leu His Ala Gly
              20                  25                  30        
 Pro Asn Val Tyr Lys Phe Lys Ile Arg Tyr Gly Lys Ser Ile Arg Gly
          35                  40                  45            
 Glu Glu Ile Glu Asn Lys Glu Val Ile Thr Gln Glu Leu Glu His His
      50                  55                  60                
 Phe Pro Asp Lys Ser Lys Trp Glu Arg Val Ser His Leu Lys Phe Lys
  65                  70                  75                  80
 His Gly Glu Ile Ile Leu Ile Pro Tyr Pro Phe Val Phe Thr Leu Tyr
                  85                  90                  95    
 Val Glu Met Lys Trp Phe His Glu Asn Leu Ser Pro Gly Lys Trp Asn
             100                 105                 110        
 Asp Val Asn Val Asp Gly Arg Glu Glu Asn Gly Leu Ala Val Pro Ala
         115                 120                 125            
 Arg Tyr Arg Glu Arg Gly Tyr Gln Ile Arg Leu Gln Pro Tyr Ser Ala
     130                 135                 140                
 Gln Asn Arg Glu Arg Lys Thr Gln Gln Gly Leu Gln Glu Thr Leu Ala
 145                 150                 155                 160
 Ser Asp Ile Thr Asp Val Gln Lys Gln Asp Ser Glu Trp Gly His Ser
                 165                 170                 175    
 Leu Pro Gly Arg Ile Val Pro Pro Leu Gln His Asn Ser Pro Pro Pro
             180                 185                 190        
 Lys Glu Arg Ala Ala Thr Gly Phe Phe Gly Phe Leu Ser Ser Leu Phe
         195                 200                 205            
 Pro Phe Arg Tyr Phe Phe Arg Lys Ser Ser His Ser
     210                 215                 220



      <210> 852
      <211> 107
      <212> PRT
      <213> Homo sapiens


      <400> 852
 Met Tyr Glu Gln Asn Gly Asn Thr Asn Asn Glu Thr Glu Asn Pro Lys
   1               5                  10                  15    
 Gly Asn Gln Thr Glu Asn Met Lys Leu Lys Ser Thr Ile Asn Glu Met
              20                  25                  30        
 Lys Asn Ser Leu Lys Gly Phe Lys Gly Arg Ser Ala Gln Ala Gln Glu
          35                  40                  45            
 Arg Ile Ser Glu Cys Glu Asp Arg Thr Met Gly Asn Ile Lys Tyr Pro
      50                  55                  60                
 Glu Gln Lys Glu Lys Arg Leu Lys Lys Ser Glu Gln Ser Leu Arg Asp
  65                  70                  75                  80
 Leu Val Asp Ile Ile Lys Gln Ala Asn Ile Cys Leu Val Gly Leu Leu
                  85                  90                  95    
 Glu Gly Glu Glu Arg Asn Gly Gln Asp Ile Ile
             100                 105        



      <210> 853
      <211> 1092
      <212> PRT
      <213> Homo sapiens


      <400> 853
 Met Gly Ala Phe Asn Val Glu Arg Lys Gly Asp Arg Ser Leu Glu Pro
   1               5                  10                  15    
 Pro Leu Ala Lys Pro Val Glu Ala Arg Arg Gly Asp Arg Leu Gly Met
              20                  25                  30        
 Pro Gly Ser Ala Gly Ala Arg Ser Gln Glu Glu Glu Ile Val Glu Thr
          35                  40                  45            
 Asn Asn Met Arg Ser Tyr Arg Ile Pro Leu Leu Val Ile Ser Ser Gln
      50                  55                  60                
 Glu Ser Lys Lys His Pro Val Phe Leu Ile Leu Met Met Ser Glu Gly
  65                  70                  75                  80
 Lys Pro Pro Asp Lys Lys Arg Pro Arg Arg Ser Leu Ser Ile Ser Lys
                  85                  90                  95    
 Asn Lys Lys Lys Ala Ser Asn Ser Ile Ile Ser Cys Phe Asn Asn Ala
             100                 105                 110        
 Pro Pro Ala Lys Leu Ala Cys Pro Val Cys Ser Lys Met Val Pro Arg
         115                 120                 125            
 Tyr Asp Leu Asn Arg His Leu Asp Glu Met Cys Ala Asn Asn Asp Phe
     130                 135                 140                
 Val Gln Val Asp Pro Gly Gln Val Gly Leu Ile Asn Ser Asn Val Ser
 145                 150                 155                 160
 Met Val Asp Leu Thr Ser Val Thr Leu Glu Asp Val Thr Pro Lys Lys
                 165                 170                 175    
 Ser Pro Pro Pro Lys Thr Asn Leu Thr Pro Gly Gln Ser Asp Ser Ala
             180                 185                 190        
 Lys Arg Glu Val Lys Gln Lys Ile Ser Pro Tyr Phe Lys Ser Asn Asp
         195                 200                 205            
 Val Val Cys Lys Asn Gln Asp Glu Leu Arg Asn Arg Ser Val Lys Val
     210                 215                 220                
 Ile Cys Leu Gly Ser Leu Ala Ser Lys Leu Ser Arg Lys Tyr Val Lys
 225                 230                 235                 240
 Ala Lys Lys Ser Ile Asp Lys Asp Glu Glu Phe Ala Gly Ser Ser Pro
                 245                 250                 255    
 Gln Ser Ser Lys Ser Thr Val Val Lys Ser Leu Ile Asp Asn Ser Ser
             260                 265                 270        
 Glu Ile Glu Asp Glu Asp Gln Ile Leu Glu Asn Ser Ser Gln Lys Glu
         275                 280                 285            
 Asn Val Phe Lys Cys Asp Ser Leu Lys Glu Glu Cys Ile Pro Glu His
     290                 295                 300                
 Met Val Arg Gly Ser Lys Ile Met Glu Ala Glu Ser Gln Lys Ala Thr
 305                 310                 315                 320
 Arg Glu Cys Glu Lys Ser Ala Leu Thr Pro Gly Phe Ser Asp Asn Ala
                 325                 330                 335    
 Ile Met Leu Phe Ser Pro Asp Phe Thr Leu Arg Asn Thr Leu Lys Ser
             340                 345                 350        
 Thr Ser Glu Asp Ser Leu Val Lys Gln Glu Cys Ile Lys Glu Val Val
         355                 360                 365            
 Glu Lys Arg Glu Ala Cys His Cys Glu Glu Val Lys Met Thr Val Ala
     370                 375                 380                
 Ser Glu Ala Lys Ile Gln Leu Ser Asp Ser Glu Ala Lys Ser His Ser
 385                 390                 395                 400
 Ser Ala Asp Asp Ala Ser Ala Trp Ser Asn Ile Gln Glu Ala Pro Leu
                 405                 410                 415    
 Gln Asp Asp Ser Cys Leu Asn Asn Asp Ile Pro His Ser Ile Pro Leu
             420                 425                 430        
 Glu Gln Gly Ser Ser Cys Asn Gly Pro Gly Gln Thr Thr Gly His Pro
         435                 440                 445            
 Tyr Tyr Leu Arg Ser Phe Leu Val Val Leu Lys Thr Val Leu Glu Asn
     450                 455                 460                
 Glu Asp Asp Met Leu Leu Phe Asp Glu Gln Glu Lys Gly Ile Val Thr
 465                 470                 475                 480
 Lys Phe Tyr Gln Leu Ser Ala Thr Gly Gln Lys Leu Tyr Val Arg Leu
                 485                 490                 495    
 Phe Gln Arg Lys Leu Ser Trp Ile Lys Met Thr Lys Leu Glu Tyr Glu
             500                 505                 510        
 Glu Ile Ala Leu Asp Leu Thr Pro Val Ile Glu Glu Leu Thr Asn Ala
         515                 520                 525            
 Gly Phe Leu Gln Thr Glu Ser Glu Leu Gln Glu Leu Ser Glu Val Leu
     530                 535                 540                
 Glu Leu Leu Ser Ala Pro Glu Leu Lys Ser Leu Ala Lys Thr Phe His
 545                 550                 555                 560
 Leu Val Asn Pro Asn Gly Gln Lys Gln Gln Leu Val Asp Ala Phe Leu
                 565                 570                 575    
 Lys Leu Ala Lys Gln Arg Ser Val Cys Thr Trp Gly Lys Asn Lys Pro
             580                 585                 590        
 Gly Ile Gly Ala Val Ile Leu Lys Arg Ala Lys Ala Leu Ala Gly Gln
         595                 600                 605            
 Ser Val Arg Ile Cys Lys Gly Pro Arg Ala Val Phe Ser Arg Ile Leu
     610                 615                 620                
 Leu Leu Phe Ser Leu Thr Asp Ser Met Glu Asp Glu Asp Ala Ala Cys
 625                 630                 635                 640
 Gly Gly Gln Gly Gln Leu Ser Thr Val Leu Leu Val Asn Leu Gly Arg
                 645                 650                 655    
 Met Glu Phe Pro Ser Tyr Thr Ile Asn Arg Lys Thr His Ile Phe Gln
             660                 665                 670        
 Asp Arg Asp Asp Leu Ile Arg Tyr Ala Ala Ala Thr His Met Leu Ser
         675                 680                 685            
 Asp Ile Ser Ser Ala Met Ala Asn Gly Asn Trp Glu Glu Ala Lys Glu
     690                 695                 700                
 Leu Ala Gln Cys Ala Lys Arg Asp Trp Asn Arg Leu Lys Asn His Pro
 705                 710                 715                 720
 Ser Leu Arg Cys His Glu Asp Leu Pro Leu Phe Leu Arg Cys Phe Thr
                 725                 730                 735    
 Val Gly Trp Ile Tyr Thr Arg Ile Leu Ser Arg Phe Val Glu Ile Leu
             740                 745                 750        
 Gln Arg Leu His Met Tyr Glu Glu Ala Val Arg Glu Leu Glu Ser Leu
         755                 760                 765            
 Leu Ser Gln Arg Ile Tyr Cys Pro Asp Ser Arg Gly Arg Trp Trp Asp
     770                 775                 780                
 Arg Leu Ala Leu Asn Leu His Gln His Leu Lys Arg Leu Glu Pro Thr
 785                 790                 795                 800
 Ile Lys Cys Ile Thr Glu Gly Leu Ala Asp Pro Glu Val Arg Thr Gly
                 805                 810                 815    
 His Arg Leu Ser Leu Tyr Gln Arg Ala Val Arg Leu Arg Glu Ser Pro
             820                 825                 830        
 Ser Cys Lys Lys Phe Lys His Leu Phe Gln Gln Leu Pro Glu Met Ala
         835                 840                 845            
 Val Gln Asp Val Lys His Val Thr Ile Thr Gly Arg Leu Cys Pro Gln
     850                 855                 860                
 Arg Gly Met Cys Lys Ser Val Phe Val Met Glu Ala Gly Glu Ala Ala
 865                 870                 875                 880
 Asp Pro Thr Thr Val Leu Cys Ser Val Glu Glu Leu Ala Leu Ala His
                 885                 890                 895    
 Tyr Arg Arg Ser Gly Phe Asp Gln Gly Ile His Gly Glu Gly Ser Thr
             900                 905                 910        
 Phe Ser Thr Leu Tyr Gly Leu Leu Leu Trp Asp Ile Ile Phe Met Asp
         915                 920                 925            
 Gly Ile Pro Asp Val Phe Arg Asn Ala Cys Gln Ala Phe Pro Leu Asp
     930                 935                 940                
 Leu Cys Thr Asp Ser Phe Phe Thr Ser Arg Arg Pro Ala Leu Glu Ala
 945                 950                 955                 960
 Arg Leu Gln Leu Ile His Asp Ala Pro Glu Glu Ser Leu Arg Ala Trp
                 965                 970                 975    
 Val Ala Ala Thr Trp His Glu Gln Glu Gly Arg Val Ala Ser Leu Val
             980                 985                 990        
 Ser Trp Asp Arg Phe Thr Ser Leu Gln Gln Ala Gln Asp Leu Val Ser
         995                1000                1005            
 Cys Leu Gly Gly Pro Val Leu Ser Gly Val Cys Arg His Leu Ala Ala
    1010                1015                1020                
 Asp Phe Arg His Cys Arg Gly Gly Leu Pro Asp Leu Val Val Trp Asn
1025                1030                1035                1040
 Ser Gln Ser Arg His Phe Lys Leu Val Glu Val Lys Gly Pro Asn Asp
                1045                1050                1055    
 Arg Leu Ser His Lys Gln Met Ile Trp Leu Ala Glu Leu Gln Lys Leu
            1060                1065                1070        
 Gly Ala Glu Val Glu Val Cys His Val Val Ala Val Gly Ala Lys Ser
        1075                1080                1085            
 Gln Ser Leu Ser
    1090        



      <210> 854
      <211> 316
      <212> PRT
      <213> Homo sapiens


      <400> 854
 Met Ala Ser Pro Gln Gly Gly Gln Ile Ala Ile Ala Met Arg Leu Arg
   1               5                  10                  15    
 Asn Gln Leu Gln Ser Val Tyr Lys Met Asp Pro Leu Arg Asn Glu Glu
              20                  25                  30        
 Glu Val Arg Val Lys Ile Lys Asp Leu Asn Glu His Ile Val Cys Cys
          35                  40                  45            
 Leu Cys Ala Gly Tyr Phe Val Asp Ala Thr Thr Ile Thr Glu Cys Leu
      50                  55                  60                
 His Thr Phe Cys Lys Ser Cys Ile Val Lys Tyr Leu Gln Thr Ser Lys
  65                  70                  75                  80
 Tyr Cys Pro Met Cys Asn Ile Lys Ile His Glu Thr Gln Pro Leu Leu
                  85                  90                  95    
 Asn Leu Lys Leu Asp Arg Val Met Gln Asp Ile Val Tyr Lys Leu Val
             100                 105                 110        
 Pro Gly Leu Gln Asp Ser Glu Glu Lys Arg Ile Arg Glu Phe Tyr Gln
         115                 120                 125            
 Ser Arg Gly Leu Asp Arg Val Thr Gln Pro Thr Gly Glu Glu Pro Ala
     130                 135                 140                
 Leu Ser Asn Leu Gly Leu Pro Phe Ser Ser Phe Asp His Ser Lys Ala
 145                 150                 155                 160
 His Tyr Tyr Arg Tyr Asp Glu Gln Leu Asn Leu Cys Leu Glu Arg Leu
                 165                 170                 175    
 Ser Ser Gly Lys Asp Lys Asn Lys Ser Val Leu Gln Asn Lys Tyr Val
             180                 185                 190        
 Arg Cys Ser Val Arg Ala Glu Val Arg His Leu Arg Arg Val Leu Cys
         195                 200                 205            
 His Arg Leu Met Leu Asn Pro Gln His Val Gln Leu Leu Phe Asp Asn
     210                 215                 220                
 Glu Val Leu Pro Asp His Met Thr Met Lys Gln Ile Trp Leu Ser Arg
 225                 230                 235                 240
 Trp Phe Gly Lys Asp Ser His Pro Lys Ala Thr Ala Pro Gly Phe Ala
                 245                 250                 255    
 Pro Ala Phe Gly Thr Glu Glu Asp Gly Ser Leu Ser Gln Pro Gly Gln
             260                 265                 270        
 Ser Phe Pro Gly Leu Asp Gly Lys Lys Asp Phe Pro Arg Arg Gly Tyr
         275                 280                 285            
 Ser Glu Gly Pro Pro Thr Leu Leu His Ile His Arg Ile Gln Trp Asn
     290                 295                 300                
 Val Arg Ala Gly Asn Pro Arg Leu Lys Val Val Tyr
 305                 310                 315    



      <210> 855
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 855
 Met Val Leu Leu Glu Ser Glu Gln Phe Leu Thr Glu Leu Thr Arg Leu
   1               5                  10                  15    
 Phe Gln Lys Cys Arg Thr Ser Gly Ser Val Tyr Ile Thr Leu Lys Lys
              20                  25                  30        
 Tyr Asp Gly Arg Thr Lys Pro Ile Pro Lys Lys Gly Thr Val Glu Gly
          35                  40                  45            
 Phe Glu Pro Ala Asp Asn Lys Cys Leu Leu Arg Ala Thr Asp Gly Lys
      50                  55                  60                
 Lys Lys Ile Ser Thr Val Val Ser Ser Lys Glu Val Asn Lys Phe Gln
  65                  70                  75                  80
 Met Ala Tyr Ser Asn Leu Leu Arg Ala Asn Met Asp Gly Leu Lys Lys
                  85                  90                  95    
 Arg Asp Lys Lys Lys Gln Gln Gln Gln Gln Gln Gln Gln His Ser Lys
             100                 105                 110        
 Gly His Thr Phe Pro Ala Phe Thr Asn
         115                 120    



      <210> 856
      <211> 226
      <212> PRT
      <213> Homo sapiens


      <400> 856
 Met Ser Met Trp Gly Ile Ser Thr Ala Leu Ala Ser Ser Arg Pro Arg
   1               5                  10                  15    
 Ala Glu Ser Ala Ser Met Thr Glu Arg Arg Val Pro Phe Ser Leu Leu
              20                  25                  30        
 Arg Gly Pro Ser Trp Asp Pro Phe Arg Asp Trp Tyr Pro His Ser Arg
          35                  40                  45            
 Leu Phe Asp Gln Ala Phe Gly Leu Pro Arg Leu Pro Glu Glu Trp Ser
      50                  55                  60                
 Gln Trp Leu Gly Gly Ser Ser Trp Pro Gly Tyr Val Arg Pro Leu Pro
  65                  70                  75                  80
 Pro Ala Ala Ile Glu Ser Pro Ala Val Ala Ala Pro Ala Tyr Ser Arg
                  85                  90                  95    
 Ala Leu Ser Arg Gln Leu Ser Ser Gly Val Ser Glu Ile Arg His Thr
             100                 105                 110        
 Ala Asp Arg Trp Arg Val Ser Leu Asp Val Asn His Phe Ala Pro Asp
         115                 120                 125            
 Glu Leu Thr Val Lys Thr Lys Asp Gly Val Val Glu Ile Thr Gly Lys
     130                 135                 140                
 His Glu Glu Arg Gln Asp Glu His Gly Tyr Ile Ser Arg Cys Phe Thr
 145                 150                 155                 160
 Arg Lys Tyr Thr Leu Pro Pro Gly Val Asp Pro Thr Gln Val Ser Ser
                 165                 170                 175    
 Ser Leu Ser Pro Glu Gly Thr Leu Thr Val Glu Ala Pro Met Pro Lys
             180                 185                 190        
 Leu Ala Thr Gln Ser Asn Glu Ile Thr Ile Pro Val Thr Phe Glu Ser
         195                 200                 205            
 Arg Ala Gln Leu Gly Gly Pro Glu Ala Ala Lys Ser Asp Glu Thr Ala
     210                 215                 220                
 Ala Lys
 225    



      <210> 857
      <211> 127
      <212> PRT
      <213> Homo sapiens


      <400> 857
 Met Arg Thr Lys Met Arg Ile Met Gly Phe Asn Ala Ala Ala Ile Lys
   1               5                  10                  15    
 Pro Leu Asn Glu Gly Ala Ala Ala Glu Leu Gly Ala Glu Leu Leu Gly
              20                  25                  30        
 Glu Gly Ile Ile Phe Ile Thr Ala Cys Ser Cys Leu Met Leu Glu Tyr
          35                  40                  45            
 Trp Arg His Gln Leu Gln Gln Arg Arg Lys Glu Lys Glu Arg Arg Val
      50                  55                  60                
 Ala Arg Glu Ala Leu Arg Gly Glu Val Gly His Leu Gly Leu Ala Leu
  65                  70                  75                  80
 Glu Glu Leu Gln Ala Gln Val Gln Ala Thr Ser Thr Gln Leu Ala Leu
                  85                  90                  95    
 Glu Glu Leu Arg Ala Gln Leu Gln Glu Val Arg Ala His Leu Cys Leu
             100                 105                 110        
 Arg Asp Pro Pro Pro Ala Pro Pro Val Ala Pro Ala Ser Glu Lys
         115                 120                 125        



      <210> 858
      <211> 268
      <212> PRT
      <213> Homo sapiens


      <400> 858
 Met Glu Leu Pro Asn Tyr Ser Arg Gln Leu Leu Gln Gln Leu Tyr Thr
   1               5                  10                  15    
 Leu Cys Lys Glu Gln Gln Phe Cys Asp Cys Thr Ile Ser Ile Gly Thr
              20                  25                  30        
 Ile Tyr Phe Arg Ala His Lys Leu Val Leu Ala Ala Ala Ser Leu Leu
          35                  40                  45            
 Phe Lys Thr Leu Leu Asp Asn Thr Asp Thr Ile Ser Ile Asp Ala Ser
      50                  55                  60                
 Val Val Ser Pro Glu Glu Phe Ala Leu Leu Leu Glu Met Met Tyr Thr
  65                  70                  75                  80
 Gly Lys Leu Pro Val Gly Lys His Asn Phe Ser Lys Ile Ile Ser Leu
                  85                  90                  95    
 Ala Asp Ser Leu Gln Met Phe Asp Val Ala Val Ser Cys Lys Asn Leu
             100                 105                 110        
 Leu Thr Ser Leu Val Asn Cys Ser Val Gln Gly Gln Val Val Arg Asp
         115                 120                 125            
 Val Ser Ala Pro Ser Ser Glu Thr Phe Arg Lys Glu Pro Glu Lys Pro
     130                 135                 140                
 Gln Val Glu Ile Leu Ser Ser Glu Gly Ala Gly Glu Pro His Ser Ser
 145                 150                 155                 160
 Pro Glu Leu Ala Ala Thr Pro Gly Gly Pro Val Lys Ala Glu Thr Glu
                 165                 170                 175    
 Glu Ala Ala His Ser Val Ser Gln Glu Met Ser Val Asn Ser Pro Thr
             180                 185                 190        
 Ala Gln Glu Ser Gln Arg Asn Ala Glu Thr Pro Ala Glu Thr Pro Thr
         195                 200                 205            
 Thr Ala Glu Ala Cys Ser Pro Ser Pro Ala Val Gln Thr Phe Ser Glu
     210                 215                 220                
 Ala Lys Lys Thr Ser Thr Glu Pro Gly Cys Glu Arg Lys His Tyr Gln
 225                 230                 235                 240
 Leu Asn Phe Leu Leu Glu Asn Glu Gly Val Phe Ser Asp Ala Leu Met
                 245                 250                 255    
 Val Thr Gln Asp Val Leu Lys Lys Lys Lys Lys Lys
             260                 265            



      <210> 859
      <211> 226
      <212> PRT
      <213> Homo sapiens


      <400> 859
 Met Cys Arg His Arg Pro Gly Gly Ser Glu Cys Trp Gln Pro Arg Glu
   1               5                  10                  15    
 Gly Pro Ala Phe Pro Ala Glu Gly Arg Glu Ala Leu Pro Thr Ala Leu
              20                  25                  30        
 Gly Leu Arg Ile Asn Lys Tyr Lys Asn Tyr Tyr Glu Val Leu Gly Val
          35                  40                  45            
 Thr Lys Asp Ser Gly Asp Glu Asp Leu Lys Lys Ala Tyr Arg Lys Leu
      50                  55                  60                
 Ala Leu Lys Phe His Pro Asp Lys Asn His Ala Pro Gly Ala Thr Asp
  65                  70                  75                  80
 Ala Phe Lys Lys Val Gly Asn Ala Tyr Ala Val Leu Ser Asn Pro Glu
                  85                  90                  95    
 Lys Arg Lys Gln Tyr Asp Leu Thr Gly Asn Glu Glu Gln Ala Cys Asn
             100                 105                 110        
 His Gln Asn Asn Gly Arg Phe Asn Phe His Arg Gly Phe Val Lys Ser
         115                 120                 125            
 Gly Thr Gly Gln Thr Ile Lys Thr Gln Thr Glu Asn Leu Gly Gly Val
     130                 135                 140                
 Tyr Tyr Val Ser Lys Asp Phe Lys Asn Glu Tyr Lys Gly Met Leu Leu
 145                 150                 155                 160
 Gln Lys Ala Glu Lys Ser Val Glu Glu Asp Tyr Val Thr Asn Ile Arg
                 165                 170                 175    
 Asn Asn Cys Trp Lys Glu Arg Gln Gln Lys Thr Asp Met Gln Tyr Ala
             180                 185                 190        
 Ala Lys Val Tyr Arg Gly Asp Arg Leu Arg Arg Lys Ser Asp Ala Leu
         195                 200                 205            
 Ser Met Asp Asn Cys Lys Glu Leu Glu Arg Leu Thr Gly Leu Tyr Lys
     210                 215                 220                
 Gly Gly
 225    



      <210> 860
      <211> 294
      <212> PRT
      <213> Homo sapiens


      <400> 860
 Met Ala Arg Ile Leu Ser Arg Gly Leu Gln Lys Thr Gly Gly Thr Ser
   1               5                  10                  15    
 Lys Asn Gln Arg Ser Trp Met Trp Arg Asn Val Arg Ser Thr Glu Glu
              20                  25                  30        
 Gln Gln Leu Val Glu Arg Asp Thr Val Gln Ile Pro Phe His Val Gly
          35                  40                  45            
 Thr Gly His Phe Pro Asp Phe Leu Arg Leu Gly Ile Phe Thr Val Lys
      50                  55                  60                
 Gly Met Leu Leu Tyr Pro Lys Thr Ser Lys Ile Val Gln Arg Arg Trp
  65                  70                  75                  80
 Lys Phe Val Pro Val Thr Asn Asn Ala Glu Val Gln Val Gly Glu Cys
                  85                  90                  95    
 Phe Phe Tyr Met Gln Ser Leu Met Asn Pro Gly Ser Phe His Pro Val
             100                 105                 110        
 Ala Val Thr Lys Gly Ile Val Phe Val Cys Ile Val Ser Ala Arg Pro
         115                 120                 125            
 Gln Ala His Ser Tyr Ser Ala Gln Gly Lys Lys Glu Glu Ser Cys Ser
     130                 135                 140                
 Gly Thr Arg Ser Phe Phe Thr Leu Lys Met Thr Gln Lys Leu His Leu
 145                 150                 155                 160
 Ala Leu Pro Cys Val Pro His Trp Pro Glu Leu Ser His Met Ala Thr
                 165                 170                 175    
 Leu Ser Arg Lys Gly Asp Cys Trp Ser Ser Lys Met Val Ser Val Ile
             180                 185                 190        
 Pro Val Lys Glu Lys Lys Leu Leu Asp Val Lys Leu Gly Glu Leu Pro
         195                 200                 205            
 Ser Trp Ile Leu Met Gln Asp Phe Thr Pro Ser Gly Ile Ala Gly Ala
     210                 215                 220                
 Phe Gln Arg Gly Phe Tyr Trp Tyr Tyr Asn Lys Tyr Ile Asp Val Lys
 225                 230                 235                 240
 Lys Gly Cys Leu Arg Gly Phe His Gly Thr Gly Ser Leu His Ala Leu
                 245                 250                 255    
 Gln Leu Leu Pro Phe Leu Gln Gly Ala Gln Ala Pro Ala Ala Thr Gln
             260                 265                 270        
 Val Ser Leu Lys Lys Lys Ala His Ser Ala Leu Pro His Thr Thr Phe
         275                 280                 285            
 Leu Ala Arg Ala Pro Pro
     290                



      <210> 861
      <211> 416
      <212> PRT
      <213> Homo sapiens


      <400> 861
 Met Ala Gly Gly Pro Pro Lys Ala Leu Pro Ser Thr Gly Pro His Ser
   1               5                  10                  15    
 Leu Arg Asp Met Pro His Pro Leu Ala Gly Ser Ser Ser Glu Glu Ala
              20                  25                  30        
 Val Gly Gly Asp Ser Thr Pro Ser Pro Asp Leu Leu Met Ala Arg Ser
          35                  40                  45            
 Phe Gly Asp Lys Asp Leu Ile Leu Pro Asn Gly Gly Thr Pro Ala Gly
      50                  55                  60                
 Thr Ser Ser Pro Ala Ser Ser Ser Ser Leu Leu Asn Arg Leu Gln Leu
  65                  70                  75                  80
 Asp Asp Asp Ile Asp Gly Glu Thr Arg Asp Leu Phe Val Ile Val Asp
                  85                  90                  95    
 Asp Pro Lys Lys His Val Cys Thr Met Glu Thr Tyr Ile Thr Tyr Arg
             100                 105                 110        
 Ile Thr Thr Lys Ser Thr Arg Val Glu Phe Asp Leu Pro Glu Tyr Ser
         115                 120                 125            
 Val Arg Arg Arg Tyr Gln Asp Phe Asp Trp Leu Arg Ser Lys Leu Glu
     130                 135                 140                
 Glu Ser Gln Pro Thr His Leu Ile Pro Pro Leu Pro Glu Lys Phe Val
 145                 150                 155                 160
 Val Lys Gly Val Val Asp Arg Phe Ser Glu Glu Phe Val Glu Thr Arg
                 165                 170                 175    
 Arg Lys Ala Leu Asp Lys Phe Leu Lys Arg Ile Thr Asp His Pro Val
             180                 185                 190        
 Leu Ser Phe Asn Glu His Phe Asn Ile Phe Leu Thr Ala Lys Asp Leu
         195                 200                 205            
 Asn Ala Tyr Lys Lys Gln Gly Ile Ala Leu Leu Thr Arg Met Gly Glu
     210                 215                 220                
 Ser Val Lys His Val Thr Gly Gly Tyr Lys Leu Arg Thr Arg Pro Leu
 225                 230                 235                 240
 Glu Phe Ala Ala Ile Gly Asp Tyr Leu Asp Thr Phe Ala Leu Lys Leu
                 245                 250                 255    
 Gly Thr Ile Asp Arg Ile Ala Gln Arg Ile Ile Lys Glu Glu Ile Glu
             260                 265                 270        
 Tyr Leu Val Glu Leu Arg Glu Tyr Gly Pro Val Tyr Ser Thr Trp Ser
         275                 280                 285            
 Ala Leu Glu Gly Glu Leu Ala Glu Pro Leu Glu Gly Val Ser Ala Cys
     290                 295                 300                
 Ile Gly Asn Cys Ser Thr Ala Leu Glu Glu Leu Thr Asp Asp Met Thr
 305                 310                 315                 320
 Glu Asp Phe Leu Pro Val Leu Arg Glu Tyr Ile Leu Tyr Ser Asp Ser
                 325                 330                 335    
 Met Lys Ser Val Leu Lys Lys Arg Asp Gln Val Gln Ala Glu Tyr Glu
             340                 345                 350        
 Ala Lys Leu Glu Ala Val Ala Leu Arg Lys Glu Asp Arg Pro Lys Val
         355                 360                 365            
 Pro Ala Asp Val Glu Lys Cys Gln Asp Arg Met Glu Cys Phe Asn Ala
     370                 375                 380                
 Asp Leu Lys Ala Asp Met Glu Arg Trp Gln Asn Asn Lys Arg Gln Asp
 385                 390                 395                 400
 Phe Arg Gln Leu Leu Met Gly Met Ala Asp Lys Asn Ile Gln Tyr Leu
                 405                 410                 415    





      <210> 862
      <211> 415
      <212> PRT
      <213> Homo sapiens


      <400> 862
 Met Ser Tyr Arg Arg Glu Leu Glu Lys Tyr Arg Asp Leu Asp Glu Asp
   1               5                  10                  15    
 Glu Ile Leu Gly Ala Leu Thr Glu Glu Glu Leu Arg Thr Leu Glu Asn
              20                  25                  30        
 Glu Leu Asp Glu Leu Asp Pro Asp Phe Lys Glu Lys Arg Arg Glu Thr
          35                  40                  45            
 Arg Glu Arg Ile Gly Asp Asn Gly Gly Gln His Thr Val Ile Phe Ile
      50                  55                  60                
 Ser Leu Ile Thr Val Pro Ser Gln Arg Gln Leu Ser Glu Lys Asp Met
  65                  70                  75                  80
 Glu Phe Val Thr Val Thr Glu Asp Met His Phe Asn Gly Thr Lys Ile
                  85                  90                  95    
 Glu Ser Gly Ala Gly Asn Gly Leu Arg Gln Lys Asp Gln Thr Thr Lys
             100                 105                 110        
 Ala Pro Thr Gly Pro Phe Lys Arg Glu Glu Leu Leu Asp His Leu Glu
         115                 120                 125            
 Lys Gln Ala Lys Glu Phe Lys Asp Arg Glu Asp Leu Val Pro Tyr Thr
     130                 135                 140                
 Gly Glu Lys Arg Gly Lys Val Trp Val Pro Lys Gln Lys Pro Leu Asp
 145                 150                 155                 160
 Pro Val Leu Glu Ser Val Thr Leu Glu Pro Glu Leu Glu Glu Ala Leu
                 165                 170                 175    
 Ala Asn Ala Ser Asp Ala Glu Leu Cys Asp Ile Ala Ala Ile Leu Gly
             180                 185                 190        
 Met His Thr Leu Met Ser Asn Gln Gln Tyr Tyr Gln Ala Leu Ser Ser
         195                 200                 205            
 Ser Ser Ile Met Asn Lys Glu Gly Leu Asn Ser Val Ile Lys Pro Thr
     210                 215                 220                
 Gln Tyr Lys Pro Val Pro Asp Glu Glu Pro Asn Ser Thr Asp Val Glu
 225                 230                 235                 240
 Glu Thr Leu Glu Arg Ile Lys Asn Asn Asp Pro Lys Leu Glu Glu Val
                 245                 250                 255    
 Asn Leu Asn Asn Ile Arg Asn Ile Pro Ile Pro Thr Leu Lys Ala Tyr
             260                 265                 270        
 Ala Glu Ala Leu Lys Glu Asn Ser Tyr Val Lys Lys Phe Ser Ile Val
         275                 280                 285            
 Gly Thr Arg Ser Asn Asp Pro Val Ala Tyr Ala Leu Ala Glu Met Leu
     290                 295                 300                
 Lys Glu Asn Lys Val Leu Lys Thr Leu Asn Val Glu Ser Asn Phe Ile
 305                 310                 315                 320
 Ser Gly Ala Gly Ile Leu Arg Leu Val Glu Ala Leu Pro Tyr Asn Thr
                 325                 330                 335    
 Ser Leu Val Glu Met Lys Ile Asp Asn Gln Ser Gln Pro Leu Gly Asn
             340                 345                 350        
 Lys Val Glu Met Glu Ile Val Ser Met Leu Glu Lys Asn Ala Thr Leu
         355                 360                 365            
 Leu Lys Phe Gly Tyr His Phe Thr Gln Gln Gly Pro Arg Leu Arg Ala
     370                 375                 380                
 Ser Asn Ala Met Met Asn Asn Asn Asp Leu Val Arg Lys Arg Arg Leu
 385                 390                 395                 400
 Ala Asp Leu Thr Gly Pro Ile Ile Pro Lys Cys Arg Ser Gly Val
                 405                 410                 415



      <210> 863
      <211> 228
      <212> PRT
      <213> Homo sapiens


      <400> 863
 Met Leu Phe Pro Ile Gln Ala Tyr Thr Val Leu Glu Arg Phe Asp Asp
   1               5                  10                  15    
 Lys Ile Gln Ile Pro Gln Pro Ile Asn Thr Lys Trp Lys Lys Lys Lys
              20                  25                  30        
 Glu Glu Ala Tyr Asn Leu Asp Cys Tyr Glu Phe Thr Lys Val Thr Lys
          35                  40                  45            
 Asp Val Ile Lys Glu Phe Ala Asp Asp Gly Val Lys Tyr Leu Glu Leu
      50                  55                  60                
 Arg Ser Thr Pro Arg Arg Glu Asn Ala Thr Gly Met Thr Lys Lys Thr
  65                  70                  75                  80
 Tyr Val Glu Ser Ile Leu Glu Gly Ile Lys Gln Ser Lys Gln Glu Asn
                  85                  90                  95    
 Leu Asp Ile Asp Val Arg Ile Gly His Gly Thr Phe Leu Asn Ser Gly
             100                 105                 110        
 Glu Gly Gly Ser Leu Asp Leu Val Asp Phe Val Arg Gln His Arg Ile
         115                 120                 125            
 Pro Leu Glu Leu Cys Leu Thr Ser Asn Val Lys Ser Gln Thr Val Pro
     130                 135                 140                
 Ser Tyr Asp Gln His His Phe Gly Phe Trp Tyr Ser Ile Ala His Pro
 145                 150                 155                 160
 Ser Val Ile Cys Thr Asp Asp Lys Gly Val Phe Ala Thr His Leu Ser
                 165                 170                 175    
 Gln Glu Tyr Gln Leu Ala Ala Glu Thr Phe Asn Leu Thr Gln Ser Gln
             180                 185                 190        
 Val Trp Asp Leu Ser Tyr Glu Ser Ile Asn Tyr Ile Phe Ala Ser Asp
         195                 200                 205            
 Ser Thr Arg Ser Glu Leu Arg Lys Lys Trp Asn His Leu Lys Pro Arg
     210                 215                 220                
 Val Leu His Ile
 225            



      <210> 864
      <211> 337
      <212> PRT
      <213> Homo sapiens


      <400> 864
 Met Gln Leu Phe Val Arg Ala Gln Glu Leu His Thr Phe Glu Val Thr
   1               5                  10                  15    
 Gly Gln Glu Thr Val Ala Gln Ile Lys Ala His Val Ala Ser Leu Glu
              20                  25                  30        
 Gly Ile Ala Pro Glu Asp Gln Val Val Leu Leu Ala Gly Ala Pro Leu
          35                  40                  45            
 Glu Asp Glu Ala Thr Leu Gly Gln Cys Gly Val Glu Ala Leu Thr Thr
      50                  55                  60                
 Leu Glu Val Ala Gly Arg Met Leu Gly Gly Lys Val His Gly Ser Leu
  65                  70                  75                  80
 Ala Arg Ala Gly Lys Val Arg Gly Gln Thr Pro Lys Val Ala Lys Gln
                  85                  90                  95    
 Glu Lys Lys Lys Lys Lys Thr Gly Arg Ala Lys Arg Arg Met Gln Tyr
             100                 105                 110        
 Asn Arg Arg Phe Val Asn Val Val Pro Thr Phe Gly Lys Lys Lys Gly
         115                 120                 125            
 Thr Thr Phe Thr Lys Ile Phe Val Gly Gly Leu Pro Tyr His Thr Thr
     130                 135                 140                
 Asp Ala Ser Leu Arg Lys Tyr Phe Glu Gly Phe Gly Asp Ile Glu Glu
 145                 150                 155                 160
 Ala Val Val Ile Thr Asp Arg Gln Thr Gly Lys Ser Arg Gly Tyr Gly
                 165                 170                 175    
 Phe Val Thr Met Ala Asp Arg Ala Ala Ala Glu Arg Ala Cys Lys Asp
             180                 185                 190        
 Pro Asn Pro Ile Ile Asp Gly Arg Lys Ala Asn Val Asn Leu Ala Tyr
         195                 200                 205            
 Leu Gly Ala Lys Pro Arg Ser Leu Gln Thr Gly Phe Ala Ile Gly Val
     210                 215                 220                
 Gln Gln Leu His Pro Thr Leu Ile Gln Arg Thr Tyr Gly Leu Thr Pro
 225                 230                 235                 240
 His Tyr Ile Tyr Pro Pro Ala Ile Val Gln Pro Ser Val Val Ile Pro
                 245                 250                 255    
 Ala Ala Pro Val Pro Ser Leu Ser Ser Pro Tyr Ile Glu Tyr Thr Pro
             260                 265                 270        
 Ala Ser Pro Ala Tyr Ala Gln Tyr Pro Pro Ala Thr Tyr Asp Gln Tyr
         275                 280                 285            
 Pro Tyr Ala Ala Ser Pro Ala Thr Ala Ala Ser Phe Val Gly Tyr Ser
     290                 295                 300                
 Tyr Pro Ala Ala Val Pro Gln Ala Leu Ser Ala Ala Ala Pro Ala Gly
 305                 310                 315                 320
 Thr Thr Phe Val Gln Tyr Gln Ala Pro Gln Leu Gln Pro Asp Arg Met
                 325                 330                 335    
 Gln
    



      <210> 865
      <211> 451
      <212> PRT
      <213> Homo sapiens


      <400> 865
 Met Lys Ile Ser Cys Cys Ser His Asp Leu Lys Lys Glu Val Asp Leu
   1               5                  10                  15    
 Leu Gln His Leu Gln Val Ser Pro Pro Val Ser Gly Leu Gln Lys Val
              20                  25                  30        
 Val Leu Asp Val Leu Arg His Ala Leu Ser Trp Leu Glu Glu Val Glu
          35                  40                  45            
 Gln Leu Leu Arg Asp Leu Gly Ile Leu Pro Ser Ser Pro Asn Lys Gly
      50                  55                  60                
 Asn Asn Asp Val Ser Ser Ala Pro Arg Glu His Val Pro His Ser Gly
  65                  70                  75                  80
 Gly Leu Ile His Ile Cys Gly Leu Glu Gly Trp Met Glu Gly Ser Ala
                  85                  90                  95    
 Asp Gly Trp Met Asp Gly Arg Met Glu Glu Arg Met Asp Gly Ser Ile
             100                 105                 110        
 Gly Gly Trp Val Asp Gly Trp Met Asp Gly Arg Val Glu Glu Arg Met
         115                 120                 125            
 Asp Gly Arg Ile Lys Phe Asn Ser Ser Gln Glu Thr Gln Gln Ser Leu
     130                 135                 140                
 Leu Gln Glu Lys Leu Arg Glu His Leu Ala Glu Lys Glu Lys Leu Asn
 145                 150                 155                 160
 Glu Glu Arg Leu Glu Gln Glu Glu Lys Leu Lys Ala Lys Ile Arg Gln
                 165                 170                 175    
 Leu Thr Glu Glu Lys Ala Ala Leu Glu Glu Tyr Ile Thr Gln Glu Arg
             180                 185                 190        
 Asn Arg Ala Lys Glu Thr Leu Glu Glu Glu Arg Lys Arg Met Gln Glu
         195                 200                 205            
 Leu Glu Ser Leu Leu Ala Gln Gln Lys Lys Ala Leu Ala Lys Ser Ile
     210                 215                 220                
 Thr Gln Glu Lys Asn Arg Val Lys Glu Ala Leu Glu Glu Glu Gln Thr
 225                 230                 235                 240
 Arg Val Gln Glu Leu Glu Glu Arg Leu Ala Arg Gln Lys Glu Ile Ser
                 245                 250                 255    
 Glu Ser Asn Ile Ala Tyr Glu Lys Arg Lys Ala Lys Glu Ala Met Glu
             260                 265                 270        
 Lys Glu Lys Lys Lys Val Gln Asp Leu Glu Asn Arg Leu Thr Lys Gln
         275                 280                 285            
 Lys Glu Glu Leu Glu Leu Lys Glu Gln Lys Glu Asp Val Leu Asn Asn
     290                 295                 300                
 Lys Leu Ser Asp Ala Leu Ala Met Val Glu Glu Thr Gln Lys Thr Lys
 305                 310                 315                 320
 Ala Thr Glu Ser Leu Lys Ala Glu Ser Leu Ala Leu Lys Leu Asn Glu
                 325                 330                 335    
 Thr Leu Ala Glu Leu Glu Thr Thr Lys Thr Lys Met Ile Met Val Glu
             340                 345                 350        
 Glu Arg Leu Ile Leu Gln Gln Lys Met Val Lys Ala Leu Gln Asp Glu
         355                 360                 365            
 Gln Glu Ser Gln Arg His Gly Phe Glu Glu Glu Ile Met Glu Tyr Lys
     370                 375                 380                
 Glu Gln Ile Lys Gln His Ala Gln Thr Ile Val Ser Leu Glu Glu Lys
 385                 390                 395                 400
 Leu Gln Lys Val Thr Gln His His Lys Lys Ile Glu Gly Glu Ile Ala
                 405                 410                 415    
 Thr Leu Lys Asp Asn Asp Pro Gly Gln Gly Glu Lys Gly Glu Asp Leu
             420                 425                 430        
 Gly Trp Val Pro Asp Glu Glu Pro Gly Gln Asn Trp Gly Pro Ser Ser
         435                 440                 445            
 Val Val Leu
     450    



      <210> 866
      <211> 2404
      <212> PRT
      <213> Homo sapiens


      <400> 866
 Met Ser Leu Ser Glu Pro Pro Gln Pro Leu Ala Arg Lys Asp Leu Met
   1               5                  10                  15    
 Glu Ser Thr Trp Met Gln Pro Glu Arg Leu Ser Pro Gln Val His His
              20                  25                  30        
 Ser Gln Pro Gln Pro Phe Ala Gly Thr Ala Gly Ser Leu Leu Ser His
          35                  40                  45            
 Leu Leu Ser Leu Glu His Val Gly Ile Leu His Lys Asp Phe Glu Ser
      50                  55                  60                
 Ile Leu Pro Thr Arg Lys Asn His Asn Met Ala Ser Arg Pro Leu Thr
  65                  70                  75                  80
 Phe Thr Pro Gln Pro Tyr Val Thr Ser Pro Ala Ala Tyr Thr Asp Ala
                  85                  90                  95    
 Leu Leu Lys Pro Ser Ala Ser Gln Tyr Lys Ser Lys Leu Asp Arg Ile
             100                 105                 110        
 Glu Ala Leu Lys Ala Thr Ala Ala Ser Leu Ser Ser Arg Ile Glu Ser
         115                 120                 125            
 Glu Ala Lys Lys Leu Ala Gly Ala Ser Ile Asn Tyr Gly Ser Ala Trp
     130                 135                 140                
 Asn Thr Glu Tyr Asp Val Gln Gln Ala Pro Gln Glu Asp Gly Pro Trp
 145                 150                 155                 160
 Thr Lys Ala Val Thr Pro Pro Val Lys Asp Asp Asn Glu Asp Val Phe
                 165                 170                 175    
 Ser Ala Arg Ile Gln Lys Met Leu Gly Ser Cys Val Ser His Ala Thr
             180                 185                 190        
 Phe Asp Asp Asp Leu Pro Gly Val Gly Asn Leu Ser Glu Phe Lys Lys
         195                 200                 205            
 Leu Pro Glu Met Ile Arg Pro Gln Ser Ala Ile Ser Ser Phe Arg Val
     210                 215                 220                
 Arg Ser Pro Gly Pro Lys Pro Glu Gly Leu Leu Ala Gln Leu Cys Lys
 225                 230                 235                 240
 Arg Gln Thr Asp Ser Ser Ser Ser Asp Met Gln Ala Cys Ser Gln Asp
                 245                 250                 255    
 Lys Ala Lys Ile Ser Leu Gly Ser Ser Ile Asp Ser Val Ser Glu Gly
             260                 265                 270        
 Pro Leu Leu Ser Glu Gly Ser Leu Ser Glu Glu Glu Gly Asp Gln Asp
         275                 280                 285            
 Gly Gln Pro Leu Leu Lys Val Ala Glu Ile Leu Lys Glu Lys Glu Phe
     290                 295                 300                
 Cys Pro Gly Glu Arg Asn Ser Tyr Glu Pro Ile Lys Glu Phe Gln Lys
 305                 310                 315                 320
 Glu Ala Glu Lys Phe Leu Pro Leu Phe Gly His Ile Gly Gly Thr Gln
                 325                 330                 335    
 Ser Lys Gly Pro Trp Glu Glu Leu Ala Lys Gly Ser Pro His Ser Val
             340                 345                 350        
 Ile Asn Ile Phe Thr Lys Ser Tyr Gln Leu Tyr Gly Lys Gly Phe Glu
         355                 360                 365            
 Asp Lys Leu Asp Arg Gly Thr Ser Thr Ser Arg Pro Leu Asn Ala Thr
     370                 375                 380                
 Ala Thr Pro Leu Ser Gly Val Ser Tyr Glu Asp Asp Phe Val Ser Ser
 385                 390                 395                 400
 Pro Gly Thr Gly Thr Ser Thr Glu Lys Lys Ser Thr Leu Glu Pro His
                 405                 410                 415    
 Ser Thr Leu Ser Pro Gln Glu Asp His Ser Asn Arg Lys Ser Ala Tyr
             420                 425                 430        
 Asp Pro Ser Ser Val Asp Val Thr Ser Gln His Ser Ser Gly Ala Gln
         435                 440                 445            
 Ser Ala Ala Ser Ser Arg Ser Ser Thr Ser Ser Lys Gly Lys Lys Gly
     450                 455                 460                
 Lys Lys Glu Lys Thr Glu Trp Leu Asp Ser Phe Thr Gly Asn Val Gln
 465                 470                 475                 480
 Asn Ser Leu Leu Asp Glu Glu Lys Ala Glu Arg Gly Ser His Gln Gly
                 485                 490                 495    
 Lys Lys Ser Gly Thr Ser Ser Lys Leu Ser Val Lys Asp Phe Glu Gln
             500                 505                 510        
 Thr Leu Asp Thr Asp Ser Thr Leu Glu Asp Leu Ser Gly His Ser Val
         515                 520                 525            
 Ser Val Ser Ser Asp Lys Gly Arg Ser Gln Lys Thr Pro Thr Ser Pro
     530                 535                 540                
 Leu Ser Pro Ser Ser Gln Lys Ser Leu Gln Phe Asp Val Ala Gly Thr
 545                 550                 555                 560
 Ser Ser Glu Arg Ser Lys Ser Ser Val Met Pro Pro Thr Ile Thr Gly
                 565                 570                 575    
 Phe Lys Pro Asn Ala Pro Leu Thr Asp Leu Asn Pro Ala Ala Ser Arg
             580                 585                 590        
 Thr Thr Thr Glu Asn Met Ala Pro Ile Pro Gly Ser Lys Arg Phe Ser
         595                 600                 605            
 Pro Ala Gly Leu His His Arg Met Ala Ala Glu Leu Ser Tyr Leu Asn
     610                 615                 620                
 Ala Ile Glu Glu Ser Val Arg Gln Leu Ser Asp Val Glu Arg Val Arg
 625                 630                 635                 640
 Gly Ile Ser Leu Ala Gln Gln Glu Ser Val Ser Leu Ala Gln Ile Ile
                 645                 650                 655    
 Lys Ala Gln Gln Gln Arg His Glu Arg Asp Leu Ala Leu Leu Lys Leu
             660                 665                 670        
 Lys Ala Glu Gln Glu Ala Leu Glu Ser Gln Arg Gln Leu Glu Glu Thr
         675                 680                 685            
 Arg Asn Lys Ala Ala Gln Val His Ala Glu Ser Leu Gln Gln Val Val
     690                 695                 700                
 Gln Ser Gln Arg Glu Val Thr Glu Val Leu Gln Glu Ala Thr Cys Lys
 705                 710                 715                 720
 Ile Ala Ala Gln Gln Ser Glu Thr Ala Arg Leu Thr Thr Asp Ala Ala
                 725                 730                 735    
 Arg Gln Ile Cys Glu Met Ala Glu Leu Thr Arg Thr His Ile Ser Asp
             740                 745                 750        
 Ala Val Val Ala Ser Gly Ala Pro Leu Ala Ile Leu Tyr Asp His Gln
         755                 760                 765            
 Arg Gln His Leu Pro Asp Phe Val Lys Gln Leu Arg Thr Arg Thr Glu
     770                 775                 780                
 Thr Asp Arg Lys Ser Pro Ser Val Ser Leu Ser Gln Ser Lys Glu Gly
 785                 790                 795                 800
 Thr Leu Asp Ser Lys His Gln Lys Tyr Ser Ala Ser Tyr Asp Ser Tyr
                 805                 810                 815    
 Ser Glu Ser Ser Gly Tyr Lys Asn His Asp Arg Arg Ser Ser Ser Gly
             820                 825                 830        
 Ser Ser Arg Gln Glu Ser Pro Ser Val Pro Ser Cys Lys Glu Asn Glu
         835                 840                 845            
 Lys Lys Leu Asn Gly Glu Lys Ile Glu Ser Ser Ile Asp Glu Gln Val
     850                 855                 860                
 Gln Thr Ala Ala Asp Asp Ser Leu Arg Ser Asp Ser Val Pro Ser Leu
 865                 870                 875                 880
 Pro Asp Glu Lys Asp Ser Thr Ser Ile Ala Thr Glu Tyr Ser Leu Lys
                 885                 890                 895    
 Phe Asp Glu Ser Met Thr Glu Asp Glu Ile Glu Glu Gln Ser Phe Arg
             900                 905                 910        
 Ser Leu Leu Pro Ser Glu Ser His Arg Arg Phe Asn Met Glu Lys Arg
         915                 920                 925            
 Arg Gly His His Asp Asp Ser Asp Glu Glu Ala Ser Pro Glu Lys Thr
     930                 935                 940                
 Thr Leu Ser Thr Ala Lys Glu Leu Asn Met Pro Phe Ser Gly Gly Gln
 945                 950                 955                 960
 Asp Ser Phe Ser Lys Phe Thr Met Glu Met Val Arg Gln Tyr Met Lys
                 965                 970                 975    
 Glu Glu Glu Met Arg Ala Ala His Gln Ser Ser Leu Leu Arg Leu Arg
             980                 985                 990        
 Glu Lys Ala Leu Lys Glu Lys Thr Lys Ala Glu Leu Ala Trp Leu Glu
         995                1000                1005            
 His Gln Lys Lys His Leu Arg Asp Lys Gly Glu Asp Asp Lys Met Pro
    1010                1015                1020                
 Pro Leu Arg Lys Lys Gln Arg Gly Leu Leu Leu Arg Leu Gln Gln Glu
1025                1030                1035                1040
 Lys Ala Glu Ile Lys Arg Leu Gln Glu Ala Asn Lys Ala Ala Arg Lys
                1045                1050                1055    
 Glu Arg Gln Leu Ile Leu Lys Gln Gln Glu Glu Ile Glu Lys Ile Arg
            1060                1065                1070        
 Gln Thr Thr Ile Lys Leu Gln Glu Lys Leu Lys Ser Ala Gly Glu Ser
        1075                1080                1085            
 Lys Leu Asp Ser His Ser Asp Asp Asp Thr Lys Asp Asn Lys Ala Thr
    1090                1095                1100                
 Ser Pro Gly Pro Thr Asp Leu Glu Thr Arg Ser Pro Ser Pro Ile Ser
1105                1110                1115                1120
 Ile Ser Ser Ser Glu Thr Ser Ser Ile Met Gln Lys Leu Lys Lys Met
                1125                1130                1135    
 Arg Ser Arg Met Asp Glu Lys Phe Leu Thr Lys Arg Glu Gln Lys Leu
            1140                1145                1150        
 Met Gln Arg Arg Gln His Ala Glu Glu Leu Leu Glu Trp Lys Arg Arg
        1155                1160                1165            
 Leu Asp Ala Glu Glu Ala Glu Ile Arg Gln Met Glu Lys Gln Ala Leu
    1170                1175                1180                
 Ala Ala Trp Asp Lys Glu Leu Ile Lys Pro Lys Thr Pro Lys Lys Glu
1185                1190                1195                1200
 Leu Glu Asp Gln Arg Thr Glu Gln Lys Glu Ile Ala Ser Glu Glu Glu
                1205                1210                1215    
 Ser Pro Val Pro Leu Tyr Ser His Leu Asn Ser Glu Ser Ser Ile Pro
            1220                1225                1230        
 Glu Glu Leu Gly Ser Pro Ala Val Glu Tyr Val Pro Ser Glu Ser Ile
        1235                1240                1245            
 Gly Gln Glu Gln Pro Gly Ser Pro Asp His Ser Ile Leu Thr Glu Glu
    1250                1255                1260                
 Met Ile Cys Ser Gln Glu Leu Glu Ser Ser Thr Ser Pro Ser Lys His
1265                1270                1275                1280
 Ser Leu Pro Lys Ser Cys Thr Ser Val Ser Lys Gln Glu Ser Ser Lys
                1285                1290                1295    
 Gly Ser His Arg Thr Gly Gly Gln Cys His Leu Pro Ile Lys Ser His
            1300                1305                1310        
 Gln His Cys Tyr Ser Trp Ser Asp Glu Ser Leu Ser Met Thr Gln Ser
        1315                1320                1325            
 Glu Thr Thr Ser Asp Gln Ser Asp Ile Glu Gly Arg Ile Arg Ala Leu
    1330                1335                1340                
 Lys Asp Glu Leu Arg Lys Arg Lys Ser Val Val Asn Gln Leu Lys Lys
1345                1350                1355                1360
 Glu Gln Lys Lys Arg Gln Lys Glu Arg Leu Lys Ala Gln Glu Ala Ser
                1365                1370                1375    
 Leu Ile Lys Gln Leu Glu Ser Tyr Asp Glu Phe Ile Lys Lys Thr Glu
            1380                1385                1390        
 Ala Glu Leu Ser Gln Asp Leu Glu Thr Ser Pro Thr Ala Lys Pro Gln
        1395                1400                1405            
 Ile Lys Thr Leu Ser Ser Ala Ser Glu Lys Pro Lys Ile Lys Pro Leu
    1410                1415                1420                
 Thr Pro Leu His Arg Ser Glu Thr Ala Lys Asn Trp Lys Ser Leu Thr
1425                1430                1435                1440
 Glu Ser Glu Arg Ser Arg Gly Ser Leu Glu Ser Ile Ala Glu His Val
                1445                1450                1455    
 Asp Ala Ser Leu Ser Gly Ser Glu Arg Ser Val Ser Glu Arg Ser Leu
            1460                1465                1470        
 Ser Ala Tyr Ala Lys Arg Val Asn Glu Trp Asp Ser Arg Thr Glu Asp
        1475                1480                1485            
 Phe Gln Thr Pro Ser Pro Val Leu Arg Ser Ser Arg Lys Ile Arg Glu
    1490                1495                1500                
 Glu Ser Gly Asp Ser Leu Glu Asn Val Pro Ala Leu His Leu Leu Lys
1505                1510                1515                1520
 Glu Leu Asn Ala Thr Ser Arg Ile Leu Asp Met Ser Asp Gly Lys Val
                1525                1530                1535    
 Gly Glu Ser Ser Lys Lys Ser Glu Ile Lys Glu Ile Glu Tyr Thr Lys
            1540                1545                1550        
 Leu Lys Lys Ser Lys Ile Glu Asp Ala Phe Ser Lys Glu Gly Lys Ser
        1555                1560                1565            
 Asp Val Leu Leu Lys Leu Val Leu Glu Gln Gly Asp Ser Ser Glu Ile
    1570                1575                1580                
 Leu Ser Lys Lys Asp Leu Pro Leu Asp Ser Glu Asn Val Gln Lys Asp
1585                1590                1595                1600
 Leu Val Gly Leu Ala Ile Glu Asn Leu His Lys Ser Glu Glu Met Leu
                1605                1610                1615    
 Lys Glu Arg Gln Ser Asp Gln Asp Met Asn His Ser Pro Asn Ile Gln
            1620                1625                1630        
 Ser Gly Lys Asp Ile His Glu Gln Lys Asn Thr Lys Glu Lys Asp Leu
        1635                1640                1645            
 Ser Trp Ser Glu His Leu Phe Ala Pro Lys Glu Ile Pro Tyr Ser Glu
    1650                1655                1660                
 Asp Phe Glu Val Ser Ser Phe Lys Lys Glu Ile Ser Ala Glu Leu Tyr
1665                1670                1675                1680
 Lys Asp Asp Phe Glu Val Ser Ser Leu Leu Ser Leu Arg Lys Asp Ser
                1685                1690                1695    
 Gln Ser Cys Arg Asp Lys Pro Gln Pro Met Arg Ser Ser Thr Ser Gly
            1700                1705                1710        
 Ala Thr Ser Phe Gly Ser Asn Glu Glu Ile Ser Glu Cys Leu Ser Glu
        1715                1720                1725            
 Lys Ser Leu Ser Ile His Ser Asn Val His Ser Asp Arg Leu Leu Glu
    1730                1735                1740                
 Leu Lys Ser Pro Thr Glu Leu Met Lys Ser Lys Glu Arg Ser Asp Val
1745                1750                1755                1760
 Glu His Glu Gln Gln Val Thr Glu Ser Pro Ser Leu Ala Ser Val Pro
                1765                1770                1775    
 Thr Ala Asp Glu Leu Phe Asp Phe His Ile Gly Asp Arg Val Leu Ile
            1780                1785                1790        
 Gly Asn Val Gln Pro Gly Ile Leu Arg Phe Lys Gly Glu Thr Ser Phe
        1795                1800                1805            
 Ala Lys Gly Phe Trp Ala Gly Val Glu Leu Asp Lys Pro Glu Gly Asn
    1810                1815                1820                
 Asn Asn Gly Thr Tyr Asp Gly Ile Ala Tyr Phe Glu Cys Lys Glu Lys
1825                1830                1835                1840
 His Gly Ile Phe Ala Pro Pro Gln Lys Ile Ser His Ile Pro Glu Asn
                1845                1850                1855    
 Phe Asp Asp Tyr Val Asp Ile Asn Glu Asp Glu Asp Cys Tyr Ser Asp
            1860                1865                1870        
 Glu Arg Tyr Gln Cys Tyr Asn Gln Glu Gln Asn Asp Thr Glu Gly Pro
        1875                1880                1885            
 Lys Asp Arg Glu Lys Asp Val Ser Glu Tyr Phe Tyr Glu Lys Ser Leu
    1890                1895                1900                
 Pro Ser Val Asn Asp Ile Glu Ala Ser Val Asn Arg Ser Arg Ser Leu
1905                1910                1915                1920
 Lys Ile Glu Thr Asp Asn Val Gln Asp Ile Ser Gly Val Leu Glu Ala
                1925                1930                1935    
 His Val His Gln Gln Ser Ser Val Asp Ser Gln Ile Ser Ser Lys Glu
            1940                1945                1950        
 Asn Lys Asp Leu Ile Ser Asp Ala Thr Glu Lys Val Ser Ile Ala Ala
        1955                1960                1965            
 Glu Asp Asp Thr Leu Asp Asn Thr Phe Ser Glu Glu Leu Glu Lys Gln
    1970                1975                1980                
 Gln Gln Phe Thr Glu Glu Glu Asp Asn Leu Tyr Ala Glu Ala Ser Glu
1985                1990                1995                2000
 Lys Leu Cys Thr Pro Leu Leu Asp Leu Leu Thr Arg Glu Lys Asn Gln
                2005                2010                2015    
 Leu Glu Ala Gln Leu Lys Ser Ser Leu Asn Glu Glu Lys Lys Ser Lys
            2020                2025                2030        
 Gln Gln Leu Glu Lys Ile Ser Leu Leu Thr Asp Ser Leu Leu Lys Val
        2035                2040                2045            
 Phe Val Lys Asp Thr Val Asn Gln Leu Gln Gln Ile Lys Lys Thr Arg
    2050                2055                2060                
 Asp Glu Lys Ile Gln Leu Ser Asn Gln Glu Leu Leu Gly Asp Asp Gln
2065                2070                2075                2080
 Lys Lys Val Thr Pro Gln Asp Leu Ser Gln Asn Val Glu Glu Gln Ser
                2085                2090                2095    
 Pro Ser Ile Ser Gly Cys Phe Leu Ser Ser Glu Leu Glu Asp Glu Lys
            2100                2105                2110        
 Glu Glu Ile Ser Ser Pro Asp Met Cys Pro Arg Pro Glu Ser Pro Val
        2115                2120                2125            
 Phe Gly Ala Ser Gly Gln Glu Glu Leu Ala Lys Arg Leu Ala Glu Leu
    2130                2135                2140                
 Glu Leu Ser Arg Glu Phe Leu Ser Ala Leu Gly Asp Asp Gln Asp Trp
2145                2150                2155                2160
 Phe Asp Glu Asp Phe Gly Leu Ser Ser Ser His Lys Ile Gln Lys Asn
                2165                2170                2175    
 Lys Ala Glu Glu Thr Ile Val Pro Leu Met Ala Glu Pro Lys Arg Val
            2180                2185                2190        
 Thr Gln Gln Pro Cys Glu Thr Leu Leu Ala Val Pro His Thr Ala Glu
        2195                2200                2205            
 Glu Val Glu Ile Leu Val His Asn Ala Ala Glu Glu Leu Trp Lys Trp
    2210                2215                2220                
 Lys Glu Leu Gly His Asp Leu His Ser Ile Ser Ile Pro Thr Lys Leu
2225                2230                2235                2240
 Leu Gly Cys Ala Ser Lys Gly Leu Asp Ile Glu Ser Thr Ser Lys Arg
                2245                2250                2255    
 Val Tyr Lys Gln Ala Val Phe Asp Leu Thr Lys Glu Ile Phe Glu Glu
            2260                2265                2270        
 Ile Phe Ala Glu Asp Pro Asn Leu Asn Gln Pro Val Trp Met Lys Pro
        2275                2280                2285            
 Cys Arg Ile Asn Ser Ser Tyr Phe Arg Arg Val Lys Asn Pro Asn Asn
    2290                2295                2300                
 Leu Asp Glu Ile Lys Ser Phe Ile Ala Ser Glu Val Leu Lys Leu Phe
2305                2310                2315                2320
 Ser Leu Lys Lys Glu Pro Asn His Lys Thr Asp Trp Gln Lys Met Met
                2325                2330                2335    
 Lys Phe Gly Arg Lys Lys Arg Asp Arg Val Asp His Ile Leu Val Gln
            2340                2345                2350        
 Glu Leu His Glu Glu Glu Ala Gln Trp Val Asn Tyr Asp Glu Asp Glu
        2355                2360                2365            
 Leu Cys Val Lys Met Gln Leu Ala Asp Gly Ile Phe Glu Thr Leu Ile
    2370                2375                2380                
 Lys Asp Thr Ile Asp Val Leu Asn Gln Ile Ser Glu Lys Gln Gly Arg
2385                2390                2395                2400
 Met Leu Leu Val
                



      <210> 867
      <211> 1969
      <212> PRT
      <213> Homo sapiens


      <400> 867
 Met Glu Ile Lys Glu Asp Phe Leu Cys Gln Asn Val Glu Lys Gln Ser
   1               5                  10                  15    
 Ser Ser Gly Thr Asn Cys Ser Ser Asp His Val Phe Asn Glu Asn Gly
              20                  25                  30        
 Asn Leu Glu Val Leu Val Gln Ser His Arg Asp Gly Gly Ser Thr Glu
          35                  40                  45            
 Phe Val Asp His Asp His Phe Phe Asp Glu Asp Leu Gln Ala Ala Ile
      50                  55                  60                
 Asp Phe Phe Lys Leu Pro Pro Pro Leu Leu Ser Pro Val Pro Ser Pro
  65                  70                  75                  80
 Pro Pro Met Ser Ser Pro His Pro Gly Ser Leu Pro Ser Ser Phe Ala
                  85                  90                  95    
 Pro Glu Thr Tyr Phe Gly Glu Tyr Thr Asp Ser Ser Asp Asn Asp Ser
             100                 105                 110        
 Val Gln Leu Arg Asn Ser Ala Glu Ser Val Ser Glu Asp Asp Thr Thr
         115                 120                 125            
 Glu Ser Gln Asn Tyr Phe Gly Ser Leu Arg Lys Asn Lys Gly Ser Gly
     130                 135                 140                
 Thr Trp Glu Glu Lys Pro Lys Ser His Glu Ala Ile Gln Ala Leu Asn
 145                 150                 155                 160
 Thr Trp Glu Val Asn Lys Val Thr Thr Ser Gly Leu Glu Thr Phe Thr
                 165                 170                 175    
 Ala Thr Leu Arg Glu Ser Ser Ala Thr His Ser Leu Val Gly Glu Lys
             180                 185                 190        
 His Trp Thr Thr Ala Ser Arg Ser Met Ser Asp Arg Lys Arg Asp Ile
         195                 200                 205            
 Leu His Glu Thr Lys Thr Gln Met Glu Val Arg Glu Met Asp Lys Ser
     210                 215                 220                
 Val Gln Thr Glu Lys Thr Ile His Lys Leu Thr Arg Gly Leu Cys Ile
 225                 230                 235                 240
 Glu Arg Leu Ser Ala Ser Pro Ala Gln Glu Lys Glu Ala Ala Pro Gly
                 245                 250                 255    
 Lys Ser Glu Leu Cys Ser Ser Pro Leu Gly Lys Arg Pro Leu Asn Glu
             260                 265                 270        
 Leu Met Glu Ser Glu Gly Lys Thr Val Leu Ser Lys Met Met Gly Ser
         275                 280                 285            
 Pro Lys Ser Glu Phe Thr Lys Trp Thr Arg Ile Asn Glu Ile Thr Ser
     290                 295                 300                
 Glu Pro Asp Arg Ile Thr Val Ser Gly His Phe His Arg Leu Ser Arg
 305                 310                 315                 320
 Glu Leu Glu Lys Glu Lys Glu Asp Thr Gln Gly Phe Thr Leu Gly Glu
                 325                 330                 335    
 Ser Pro Glu Ser Glu Asp Asp Asp Ser Gly Asp Gly Met Asp Val Ala
             340                 345                 350        
 Gly Leu Asp Ile Glu Thr Ser Phe Ser Ser Ser Ser Thr Leu Val Ala
         355                 360                 365            
 Leu Ser Val Gly Ser Asn Pro Gln Ser Ser Ser Gly Leu Asp Cys Gly
     370                 375                 380                
 Asn Asp Thr Asp Ile Thr Thr Lys Val Phe Ser Thr Glu Pro His His
 385                 390                 395                 400
 Ser Glu His Lys Leu Gln Thr Lys Thr Leu Asn Thr Leu His Leu Gln
                 405                 410                 415    
 Ser Glu Pro Pro Glu Cys Ser Ile Gly Gly Asn Asn Leu Glu Asn Ser
             420                 425                 430        
 Leu Cys Ala Leu Ser Pro Glu Leu Gly Ala Ser Asn Phe Asn Asp Gln
         435                 440                 445            
 Lys Ser Ser Gly Ile Glu Tyr Thr Lys Val Val Lys Gly Leu Thr Lys
     450                 455                 460                
 Ile His Ser Leu Pro Arg Ser Val Phe Met Lys Ala Thr Lys Asp Gly
 465                 470                 475                 480
 Gln Cys Glu Ser Gln Asp Pro Arg Ile Glu Leu Thr Leu Asn Lys Pro
                 485                 490                 495    
 Asp Phe Thr Ser Leu Ile Gly Ser Gln Ala Ala Leu Ile Lys Ser Gly
             500                 505                 510        
 Leu Gly Phe Val Lys Ser Thr Ser Trp His His Ser Asp Leu Leu Arg
         515                 520                 525            
 Lys Gly Gly Glu Glu Ser Leu Arg Ala Lys Ser Glu His Glu Gln Lys
     530                 535                 540                
 Thr Ser His Gln Leu Gln Lys Ala Met Pro Phe Leu Gln Asn Arg Gly
 545                 550                 555                 560
 Pro Thr Pro Lys Pro Asp Leu Leu Arg Glu Asn Asn Asn Pro Val Glu
                 565                 570                 575    
 Phe Lys Thr Thr Ala Ser Val Leu Pro Asn Gln Val Ser Val Ile Thr
             580                 585                 590        
 Lys Gln Thr Arg Pro Glu Lys Val Gln Ser Ala Lys Leu Glu His Leu
         595                 600                 605            
 Arg Pro His Arg Val Glu Pro Thr Leu Val Thr Glu Asn Ser Gly Asn
     610                 615                 620                
 Lys Thr Gly Met Ser Thr Ile Ala Lys Cys Asp Gly Glu Arg Asp Asp
 625                 630                 635                 640
 Thr Thr Gln Asn Ile Thr Glu Val Ala Ala Val Lys Ser Ile Ser Pro
                 645                 650                 655    
 Glu Val Ser Ala Ser Arg Arg Lys Leu Asp Phe Asn Ser Pro Gly Gly
             660                 665                 670        
 Ser Ser Pro Val Glu Asn Ser Asp Cys Ser Thr Asn Ser Arg Leu Ser
         675                 680                 685            
 Phe Ser Pro Glu Asn Ile Leu Ile Gln Asn Gln Asp Ile Val Arg Glu
     690                 695                 700                
 Ala Ala Val Gln Gly Asp Gly Gln Lys Gln Arg Gln Pro Gln Ala Thr
 705                 710                 715                 720
 Asp Leu Asp Ser Ser Gly Thr His Gly Ser Glu Met Leu Pro Ala Thr
                 725                 730                 735    
 Glu Val Thr Val Ser Gly Gly Phe Ser Val Glu Glu Thr Ser Cys Gly
             740                 745                 750        
 Asp Thr Gly Arg Ser Gly Gly Glu Ala Leu Ala Val Ala Asn Asp Ser
         755                 760                 765            
 Thr Ser Thr Pro Gln Asn Ala Asn Gly Leu Trp Lys Leu Lys Ser Thr
     770                 775                 780                
 Thr Pro Gly Gly Ala Leu Pro Glu Cys Phe Gly Thr Thr Asp Thr Thr
 785                 790                 795                 800
 Phe Ser Ser Ala Phe Cys Arg Lys His Gly Glu Thr Gln Asp Thr Ser
                 805                 810                 815    
 Gln Ser Ser Leu Pro Gly Thr Leu His Cys Tyr Thr Gly Ile Arg Glu
             820                 825                 830        
 Gly Gly Asp Asp Thr Glu Val Glu Ser Glu Ala Phe Ser Cys Ser Glu
         835                 840                 845            
 Gly Ser Glu Gln Gln Asp Ala Pro Asp Asp Ser Gln Lys Asn Leu Gly
     850                 855                 860                
 Asp Thr Asp Ala Ala Val Ala Glu Val Arg Pro Ser Leu Glu Val Gly
 865                 870                 875                 880
 Tyr Leu Thr Ser Ala Leu Gln Asp Phe Asn Ile Ser Thr Phe Ser Glu
                 885                 890                 895    
 Leu Asp Arg Leu Ser Thr Ser Glu Val Val Met Phe Leu Glu Ser Cys
             900                 905                 910        
 Gln Leu Gly Asp Tyr Ser Ser Gly Asp Ser Val Ser Glu Cys Ser Ser
         915                 920                 925            
 Lys Gly Thr Leu Ser Lys Glu Met Asn Lys Glu Leu Lys Ala Ser Glu
     930                 935                 940                
 Ile Gly Glu Lys Tyr Arg Lys Gln Pro Cys Glu Glu Glu Thr Leu Gly
 945                 950                 955                 960
 Thr Cys Glu Glu Trp Ile Glu Ser Glu Glu Asp Asp Tyr Ser Leu Lys
                 965                 970                 975    
 Asn Thr Ser Gln Leu Thr Gln Cys Ser Leu Glu Thr Leu Ser Glu Val
             980                 985                 990        
 Leu Thr Lys Ile Arg Gln Glu Leu Gln Thr Asn Ser Glu Asp Cys Asn
         995                1000                1005            
 Gly Lys Asp Thr Gly Ser Leu Leu Leu Leu Asn Asn Gln Pro His Lys
    1010                1015                1020                
 Gln Leu Pro Leu Asp Thr Glu Gly Ser Ser Pro Ile Ser Gly Met Pro
1025                1030                1035                1040
 Gln Asn Glu Asn Pro Gln Ser Arg Pro Glu Ala Arg Ser Asp Ala Gly
                1045                1050                1055    
 Arg Gln Thr Asp Gly Gly Glu Glu Asp Leu Pro Glu Pro Val Glu Pro
            1060                1065                1070        
 Ser Ala Leu Cys Ser Asp Ser Val Met Glu Pro Ser Ile Glu Gln Ser
        1075                1080                1085            
 Ser Asn Cys Glu Ala Glu Thr Thr Phe Gln Cys Gln Ile Ala Thr Val
    1090                1095                1100                
 Thr Ser Glu Val Ile Asn Val Leu Ile Asn Lys Asp Gln Asn Leu Val
1105                1110                1115                1120
 Ile Glu Lys Gly Asp Asn Trp Thr Ile Ile Ser Gly Val Ala Val Leu
                1125                1130                1135    
 Pro His Val Asp Gln Val Thr Leu Cys Asp Ile Pro Gly Asp Ile Pro
            1140                1145                1150        
 Ile Ser Gln Asp Gln Gly Glu Leu Glu Ala Gly Cys Ile Pro Val Thr
        1155                1160                1165            
 Ser Ala Glu Lys Ser Pro Glu Ala Ser His Thr Gly Pro Ala Phe Gln
    1170                1175                1180                
 Glu Ala Pro Cys Gly Asn Asn Leu Ser Cys Pro Gln Glu Asp Val Ser
1185                1190                1195                1200
 Ser Ser Gly Gln Ser Thr Asn Phe Asp Lys Ser Arg Leu Arg Asn Arg
                1205                1210                1215    
 Pro Val Lys Pro Ser Ile Trp Ile Ser Ser Gln Ile Tyr Asp Gln Asn
            1220                1225                1230        
 Phe Glu Thr Gln Ile Val Ala Ser Asp His Thr Tyr Tyr Asn Ser Lys
        1235                1240                1245            
 Leu Glu Pro Ser Gly Lys Asn Lys Asn Arg Ser Lys Ile Ser Asn Lys
    1250                1255                1260                
 Asp Gln Ser Asn Lys Pro Val Lys Thr Ser Ala Ser Ser Arg Val Glu
1265                1270                1275                1280
 Thr His Gln Ser Glu Val Ala Gln Ser Phe Ser Gly Glu Lys Ala Asn
                1285                1290                1295    
 Thr Lys Thr Gln Arg Ser Gln Thr Gln Thr Ile Leu Ala Asn Ala Asp
            1300                1305                1310        
 Thr Ser Thr Pro Thr Asp Cys Ser Pro Asp Thr Leu Ser Lys Ile Arg
        1315                1320                1325            
 Gln Glu Val Gly Pro Pro Leu Pro Pro Leu Leu Ala Pro Leu Ile Ala
    1330                1335                1340                
 Thr Pro Pro Arg Thr Ser Gln Pro Leu Ser Pro Leu Ile Ser Ser Ser
1345                1350                1355                1360
 Ser Pro Ser Ser Pro Ala Ser Pro Val Gly Gln Val Ser Pro Phe Arg
                1365                1370                1375    
 Glu Thr Pro Val Pro Pro Ala Met Ser Pro Trp Pro Glu Asp Pro Arg
            1380                1385                1390        
 Arg Ala Ser Pro Pro Asp Pro Ser Pro Ser Pro Ser Ala Ala Ser Ala
        1395                1400                1405            
 Ser Glu Arg Val Val Pro Ser Pro Leu Gln Phe Cys Ala Ala Thr Pro
    1410                1415                1420                
 Lys His Ala Leu Pro Val Pro Gly Arg Leu Pro Pro Cys Ala Ser Gly
1425                1430                1435                1440
 His Ala Ala Val Gly Gly Pro Gln Glu Asn Ser Val Lys Ile Leu Asp
                1445                1450                1455    
 Thr Met Tyr Pro Glu Leu Ser Ala Arg Ala Arg Thr Leu Asn Ile Leu
            1460                1465                1470        
 Lys Gly Asn Ile Gln Leu Thr Arg Gly Pro Pro Ala Asp Cys Lys Asn
        1475                1480                1485            
 Leu Pro Gly Pro Ala Ser Ala Met Ile Gly Phe Lys Thr Ile Thr Ser
    1490                1495                1500                
 Ala Ala Thr Ala Phe Val Lys Thr Gly Ser Ser Ser Gly Gly Asp Cys
1505                1510                1515                1520
 Asn Gln Asp Lys Ser Arg Asp Leu Gly Thr Gln Gln Asp Ser Ser Gly
                1525                1530                1535    
 Lys Arg Thr Leu Ser Thr Ser Thr Leu Arg Ser Ala Lys Arg Leu Arg
            1540                1545                1550        
 Leu Asp Thr Gly Ser Pro Glu Pro Glu Thr Arg Gly Val Thr Ala Glu
        1555                1560                1565            
 Gly Ile His Lys Asn Leu Pro Gly Asn Leu Pro Pro Ala Glu Val Ala
    1570                1575                1580                
 Thr Thr Asn Glu Glu Arg Ser Cys Ser Ser Pro Ala Val Ser Ala Val
1585                1590                1595                1600
 Ser Gln Leu Pro Leu Ser Pro Lys Glu Thr Val Glu Ser His Asp Lys
                1605                1610                1615    
 Ala Ile Ala Asn Ala Leu Lys Lys Ile Ala Glu Phe Ser Phe Asp Leu
            1620                1625                1630        
 Leu Pro Val Ile Arg Ser His Val Tyr Val Gly Asn Ile Ser Lys Lys
        1635                1640                1645            
 Pro Val Met Arg Asp Gln Glu Lys Glu Val Val Tyr Glu Phe Ser Thr
    1650                1655                1660                
 Thr Lys Lys His Leu Ala Glu Cys Leu Leu His Ser Ile Leu Ser Glu
1665                1670                1675                1680
 Leu Lys Ile Gln Lys Ile Ser Met Asp His Asn Tyr Ile His Ala Leu
                1685                1690                1695    
 Cys Arg Val Tyr Val Gly Ile Cys Arg Gln Leu Gly Asp Leu Glu Arg
            1700                1705                1710        
 Ala Arg Leu Phe Cys Tyr Ser Leu Leu Lys Glu Asp Phe Pro Glu Ser
        1715                1720                1725            
 Glu Lys Leu Thr Leu Phe Ile Ala Asn Met Trp His Asp Ile Phe Leu
    1730                1735                1740                
 Ser Gln Ser Val Ile Asn Lys Ala Met Gln Leu Val Ala Arg Gln Arg
1745                1750                1755                1760
 Ala Lys Gly Glu Val Leu Asn Cys Leu Arg Ala Phe Leu Asn Trp Glu
                1765                1770                1775    
 Lys Asn Ala Pro Val Asp Val Gly Phe Met Val Ser Lys Leu Leu Leu
            1780                1785                1790        
 Thr Ile Gln Leu Cys Pro Lys Thr Glu Phe Gln Pro Ser Glu Lys Phe
        1795                1800                1805            
 Gly Glu Asp Leu Ser Asp Asn Thr Trp Glu Tyr Ile Phe Ala Ile Asp
    1810                1815                1820                
 Leu Leu Cys Cys His Gln Lys Trp Ile Trp Thr His Asp Asn Ile Ile
1825                1830                1835                1840
 Ser Lys Glu Leu Trp Pro Val Met Asp Lys Trp Ile Lys Tyr Arg Lys
                1845                1850                1855    
 Gly His Ala Asn Ile Ala Tyr Thr Pro Asp Ile Ile Ile Ala Ser Ile
            1860                1865                1870        
 Leu Arg Leu Ile Gly Arg Leu Gly Gln Leu Gly Leu Lys Glu Gly Phe
        1875                1880                1885            
 Pro Ser Ala Val Lys Asn Ile Ser Ser Val Ile Gly Met Phe Ile Gln
    1890                1895                1900                
 His Ala His Asp Glu Asp Ile Pro Trp Gly Ile Gln Leu Ala Ala Val
1905                1910                1915                1920
 Tyr Ala Leu Cys Asp Leu Ser Pro Ser Asn Pro Ala Glu Ile Ser Lys
                1925                1930                1935    
 Ile Leu Glu Ala Trp Arg Arg Glu Ala Ser Lys Ser Val Pro Ser Ala
            1940                1945                1950        
 Ile Val Ser Cys Leu Glu Glu Val Ser Ala Leu Ser Thr Glu Glu Leu
        1955                1960                1965            
 Gly
    



      <210> 868
      <211> 284
      <212> PRT
      <213> Homo sapiens


      <400> 868
 Met Val Ala Pro Lys Ser His Thr Asp Asp Trp Ala Pro Gly Pro Phe
   1               5                  10                  15    
 Ser Ser Lys Pro Gln Arg Ser Gln Leu Gln Ile Phe Ser Ser Val Leu
              20                  25                  30        
 Gln Thr Ser Leu Leu Phe Leu Leu Met Gly Leu Arg Ala Ser Gly Lys
          35                  40                  45            
 Asp Ser Ala Pro Thr Val Val Ser Gly Ile Leu Gly Gly Ser Val Thr
      50                  55                  60                
 Leu Pro Leu Asn Ile Ser Val Asp Thr Glu Ile Glu Asn Val Ile Trp
  65                  70                  75                  80
 Ile Gly Pro Lys Asn Ala Leu Ala Phe Ala Arg Pro Lys Glu Asn Val
                  85                  90                  95    
 Thr Ile Met Val Lys Ser Tyr Leu Gly Arg Leu Asp Ile Thr Lys Trp
             100                 105                 110        
 Ser Tyr Ser Leu Cys Ile Ser Asn Leu Thr Leu Asn Asp Ala Gly Ser
         115                 120                 125            
 Tyr Lys Ala Gln Ile Asn Gln Arg Asn Phe Glu Val Thr Thr Glu Glu
     130                 135                 140                
 Glu Phe Thr Leu Phe Val Tyr Glu Gln Leu Gln Glu Pro Gln Val Thr
 145                 150                 155                 160
 Met Lys Ser Val Lys Val Ser Glu Asn Phe Ser Cys Asn Ile Thr Leu
                 165                 170                 175    
 Met Cys Ser Val Lys Gly Ala Glu Lys Ser Val Leu Tyr Ser Trp Thr
             180                 185                 190        
 Pro Arg Glu Pro His Ala Ser Glu Ser Asn Gly Gly Ser Ile Leu Thr
         195                 200                 205            
 Val Ser Arg Thr Pro Cys Asp Pro Asp Leu Pro Tyr Ile Cys Thr Ala
     210                 215                 220                
 Gln Asn Pro Val Ser Gln Arg Ser Ser Leu Pro Val His Val Gly Gln
 225                 230                 235                 240
 Phe Cys Thr Asp Pro Gly Ala Ser Arg Gly Arg Asn Asn Gly Gly Asp
                 245                 250                 255    
 Cys Gly Arg Gly Pro Gly Arg Ala Ser His Pro Ala Thr Cys Thr Pro
             260                 265                 270        
 Ser Leu Pro Gly His Arg Glu Gly Cys Leu Val Val
         275                 280                



      <210> 869
      <211> 631
      <212> PRT
      <213> Homo sapiens


      <400> 869
 Met Gly Leu Pro Arg Gly Pro Glu Gly Gln Gly Leu Pro Glu Val Glu
   1               5                  10                  15    
 Thr Arg Glu Asp Glu Glu Gln Asn Val Lys Leu Thr Glu Ile Leu Glu
              20                  25                  30        
 Leu Leu Val Ala Ala Gly Tyr Phe Arg Ala Arg Ile Lys Gly Leu Ser
          35                  40                  45            
 Pro Phe Asp Lys Val Val Gly Gly Met Thr Trp Cys Ile Thr Thr Cys
      50                  55                  60                
 Asn Phe Asp Val Asp Val Asp Leu Leu Phe Gln Glu Asn Ser Thr Ile
  65                  70                  75                  80
 Gly Gln Lys Ile Ala Leu Ser Glu Lys Ile Val Ser Val Leu Pro Arg
                  85                  90                  95    
 Met Lys Cys Pro His Gln Leu Glu Pro His Gln Ile Gln Gly Met Asp
             100                 105                 110        
 Phe Ile His Ile Phe Pro Val Val Gln Trp Leu Val Lys Arg Ala Ile
         115                 120                 125            
 Glu Thr Lys Glu Glu Met Gly Asp Tyr Ile Arg Ser Tyr Ser Val Ser
     130                 135                 140                
 Gln Phe Gln Lys Thr Tyr Ser Leu Pro Glu Asp Asp Asp Phe Ile Lys
 145                 150                 155                 160
 Arg Lys Glu Lys Ala Ile Lys Thr Val Val Asp Leu Ser Glu Val Tyr
                 165                 170                 175    
 Lys Pro Arg Arg Lys Tyr Lys Arg His Gln Gly Ala Glu Glu Leu Leu
             180                 185                 190        
 Asp Glu Glu Ser Arg Ile His Ala Thr Leu Leu Glu Tyr Gly Arg Arg
         195                 200                 205            
 Tyr Gly Phe Ser Arg Gln Ser Lys Met Glu Lys Ala Glu Asp Lys Lys
     210                 215                 220                
 Thr Ala Leu Pro Ala Gly Leu Ser Ala Thr Glu Lys Ala Asp Ala His
 225                 230                 235                 240
 Glu Glu Asp Glu Leu Arg Ala Ala Glu Glu Gln Arg Ile Gln Ser Leu
                 245                 250                 255    
 Met Thr Lys Met Thr Ala Met Ala Asn Glu Glu Ser Arg Leu Thr Ala
             260                 265                 270        
 Ser Ser Val Gly Gln Ile Val Gly Leu Cys Ser Ala Glu Ile Lys Gln
         275                 280                 285            
 Ile Val Ser Glu Tyr Ala Glu Lys Gln Ser Glu Leu Ser Ala Glu Glu
     290                 295                 300                
 Ser Pro Glu Lys Leu Gly Thr Ser Gln Leu His Arg Arg Lys Val Ile
 305                 310                 315                 320
 Ser Leu Asn Lys Gln Ile Ala Gln Lys Thr Lys His Leu Glu Glu Leu
                 325                 330                 335    
 Arg Ala Ser His Thr Ser Leu Gln Ala Arg Tyr Asn Glu Ala Lys Lys
             340                 345                 350        
 Thr Leu Thr Glu Leu Lys Thr Tyr Ser Glu Lys Leu Asp Lys Glu Gln
         355                 360                 365            
 Ala Ala Leu Glu Lys Ile Glu Ser Lys Ala Asp Pro Ser Ile Leu Gln
     370                 375                 380                
 Asn Leu Arg Ala Leu Val Ala Met Asn Glu Asn Leu Lys Ser Gln Glu
 385                 390                 395                 400
 Gln Glu Phe Lys Ala His Cys Arg Glu Glu Met Thr Arg Leu Gln Gln
                 405                 410                 415    
 Glu Ile Glu Asn Leu Lys Ala Glu Arg Ala Pro Arg Gly Asp Glu Lys
             420                 425                 430        
 Thr Leu Ser Ser Gly Glu Pro Pro Gly Thr Leu Thr Ser Ala Met Thr
         435                 440                 445            
 His Asp Glu Asp Leu Asp Arg Arg Tyr Asn Met Glu Lys Glu Lys Leu
     450                 455                 460                
 Tyr Lys Ile Arg Leu Leu Gln Ala Arg Arg Asn Arg Glu Ile Ala Ile
 465                 470                 475                 480
 Leu His Arg Lys Ile Asp Glu Val Pro Ser Arg Ala Glu Leu Ile Gln
                 485                 490                 495    
 Tyr Gln Lys Arg Phe Ile Glu Leu Tyr Arg Gln Ile Ser Ala Val His
             500                 505                 510        
 Lys Glu Thr Lys Gln Phe Phe Thr Leu Tyr Asn Thr Leu Asp Asp Lys
         515                 520                 525            
 Lys Val Tyr Leu Glu Lys Glu Ile Ser Leu Leu Asn Ser Ile His Glu
     530                 535                 540                
 Asn Phe Ser Gln Ala Met Ala Ser Pro Ala Ala Arg Asp Gln Phe Leu
 545                 550                 555                 560
 Arg Gln Met Glu Gln Ile Val Glu Gly Ile Lys Gln Ser Arg Met Lys
                 565                 570                 575    
 Met Glu Lys Lys Lys Gln Glu Asn Lys Met Arg Arg Asp Gln Leu Asn
             580                 585                 590        
 Asp Gln Tyr Leu Glu Leu Leu Glu Lys Gln Arg Leu Tyr Phe Lys Thr
         595                 600                 605            
 Val Lys Glu Phe Lys Glu Glu Gly Arg Lys Asn Glu Met Leu Leu Ser
     610                 615                 620                
 Lys Val Lys Ala Lys Ala Ser
 625                 630    



      <210> 870
      <211> 152
      <212> PRT
      <213> Homo sapiens


      <400> 870
 Met Glu Ser Ser Ser Asn Gly Ile Glu Trp Asn His His Gln Met Val
   1               5                  10                  15    
 Ser Asn Gly Ile Ile Glu Gln Asn Leu Met Glu Ser Ser Leu Asn Glu
              20                  25                  30        
 Leu Asn Ala Ile Ile Glu Trp Ser Arg Met Glu Ser Ser Ser Asn Gly
          35                  40                  45            
 Lys Glu Trp Asn His Arg Ile Glu Ser Asn Gly Ile Ile Ile Glu Trp
      50                  55                  60                
 Asn Arg Met Val Ser Thr Pro Asn Gly Lys Lys Arg Asn Phe Arg Met
  65                  70                  75                  80
 Glu Thr Lys Arg Ile Phe Glu Arg Thr Arg Met Glu Leu Ser Asn Gly
                  85                  90                  95    
 Met Glu Trp Asn Asn Pro Trp Thr Arg Met Gln Ser Ser Ser Asn Gly
             100                 105                 110        
 Ile Glu Trp Asn His Arg Met Asp Ser Asn Gly Ile Ile Ile Glu Arg
         115                 120                 125            
 Asn Arg Met Glu Ser Ser Ser Asp Gly Asn Glu Trp Asn His His Arg
     130                 135                 140                
 Met Glu Met Lys Gly Val Ile Ile
 145                 150        



      <210> 871
      <211> 126
      <212> PRT
      <213> Homo sapiens


      <400> 871
 Met Ala Lys Gly Thr Arg Leu Met Asp Ile Ile Ile Val Arg Ala Tyr
   1               5                  10                  15    
 Cys Lys Glu Lys Lys Glu Ser Leu Lys Cys Ile Thr Gly Ala Asp Thr
              20                  25                  30        
 Ile Ser Cys Thr Ser Val Pro Ser Leu Val Leu Ile His Thr His Gln
          35                  40                  45            
 Pro Ile Pro Asn Ala Ile Leu Asp Leu Gly Pro Trp Asp Leu Ser Ala
      50                  55                  60                
 Ser Pro Pro Val Val Gly Pro Leu Phe Asn Thr Ile Pro Leu Thr Leu
  65                  70                  75                  80
 Asp Met Val Leu Asn Lys Ala Lys Leu Ala Glu Met Thr Glu Met Lys
                  85                  90                  95    
 Phe Arg Leu Trp Ile Gly Met Lys Ile Ile Lys Ile Gln Glu Asp Gly
             100                 105                 110        
 Lys Ile Gln Ser Lys Glu Ile Glu Asp His Asn Lys Met Ile
         115                 120                 125    



      <210> 872
      <211> 1033
      <212> PRT
      <213> Homo sapiens


      <400> 872
 Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu Arg Tyr Tyr Tyr Asn Lys
   1               5                  10                  15    
 Arg Ile Leu His Lys Thr Lys Gly Lys Arg Phe Thr Tyr Lys Phe Asn
              20                  25                  30        
 Phe Asn Lys Leu Val Leu Val Asn Tyr Pro Phe Ile Asp Val Gly Leu
          35                  40                  45            
 Ala Gly Gly Ala Val Pro Gln Ser Ala Pro Pro Val Pro Ser Gly Gly
      50                  55                  60                
 Ser His Phe Arg Phe Pro Pro Ser Thr Pro Ser Glu Val Leu Ser Pro
  65                  70                  75                  80
 Thr Glu Asp Pro Arg Ser Pro Pro Ala Cys Ser Ser Ser Ser Ser Ser
                  85                  90                  95    
 Leu Phe Ser Ala Val Val Ala Arg Arg Leu Gly Arg Gly Ser Val Ser
             100                 105                 110        
 Asp Cys Ser Asp Gly Thr Ser Glu Leu Glu Glu Pro Leu Gly Glu Asp
         115                 120                 125            
 Pro Arg Ala Arg Pro Pro Gly Pro Pro Asp Leu Gly Ala Phe Arg Gly
     130                 135                 140                
 Pro Pro Leu Ala Arg Leu Pro His Asp Pro Gly Val Phe Arg Val Tyr
 145                 150                 155                 160
 Pro Arg Pro Arg Gly Gly Pro Glu Pro Leu Ser Pro Phe Pro Val Ser
                 165                 170                 175    
 Pro Leu Ala Gly Pro Gly Ser Leu Leu Pro Pro Gln Leu Ser Pro Ala
             180                 185                 190        
 Leu Pro Met Thr Pro Thr His Leu Ala Tyr Thr Pro Ser Pro Thr Leu
         195                 200                 205            
 Ser Pro Met Tyr Pro Ser Gly Gly Gly Gly Pro Ser Gly Ser Gly Gly
     210                 215                 220                
 Gly Ser His Phe Ser Phe Ser Pro Glu Asp Met Lys Arg Tyr Leu Gln
 225                 230                 235                 240
 Ala His Thr Gln Ser Val Tyr Asn Tyr His Leu Ser Pro Arg Ala Phe
                 245                 250                 255    
 Leu His Tyr Pro Gly Leu Val Val Pro Gln Pro Gln Arg Pro Asp Lys
             260                 265                 270        
 Cys Pro Leu Pro Pro Met Ala Pro Glu Thr Pro Pro Val Pro Ser Ser
         275                 280                 285            
 Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Pro Phe Lys Phe Lys Leu
     290                 295                 300                
 Gln Pro Pro Pro Leu Gly Arg Arg Gln Arg Ala Ala Gly Glu Lys Ala
 305                 310                 315                 320
 Val Ala Gly Ala Asp Lys Ser Gly Gly Ser Ala Gly Gly Leu Ala Glu
                 325                 330                 335    
 Gly Ala Gly Ala Leu Ala Pro Pro Pro Pro Pro Pro Gln Ile Lys Val
             340                 345                 350        
 Glu Pro Ile Ser Glu Gly Glu Ser Glu Glu Val Glu Val Thr Asp Ile
         355                 360                 365            
 Ser Asp Glu Asp Glu Glu Asp Gly Glu Val Phe Lys Thr Pro Arg Ala
     370                 375                 380                
 Pro Pro Ala Pro Pro Lys Pro Glu Pro Gly Glu Ala Pro Gly Ala Ser
 385                 390                 395                 400
 Gln Cys Met Pro Leu Lys Leu Arg Phe Lys Arg Arg Trp Ser Glu Asp
                 405                 410                 415    
 Cys Arg Leu Glu Gly Gly Gly Gly Pro Ala Gly Gly Phe Glu Asp Glu
             420                 425                 430        
 Gly Glu Asp Lys Lys Ser Ala Asp Arg Leu Pro Trp Thr Pro Phe Pro
         435                 440                 445            
 Asp Val Gln Arg Asp Pro Ser Phe Pro Pro Ile Ile Pro Ala Val Tyr
     450                 455                 460                
 Ser Glu Ala Phe Val Asp Phe Ile Ser Arg Arg Ala Thr Arg Leu Ser
 465                 470                 475                 480
 Val Arg Ala Glu Gly Gly Asp Gly Gly Ala Asp Asp Ser Arg Thr Ala
                 485                 490                 495    
 Ser Pro Gly Val Pro Arg Gly Gly Arg Trp Ala Gly Ala Gly Ala Gln
             500                 505                 510        
 Ala Arg Ala Ala Arg Pro Gly Arg Gly Gln Gly Pro Gly Glu Ala Ala
         515                 520                 525            
 Ala Ala Ala Ala Ala Gly Ala Ala Arg Ala Ala Arg Ala Pro Gln Pro
     530                 535                 540                
 Gly Pro Val Leu Gly Ala Met Ser Gly Gly Gly Pro Ser Gly Gly Gly
 545                 550                 555                 560
 Pro Gly Gly Ser Gly Arg Ala Arg Thr Ser Ser Phe Ala Glu Pro Gly
                 565                 570                 575    
 Gly Gly Gly Gly Gly Gly Gly Gly Gly Pro Gly Gly Ser Ala Ser Gly
             580                 585                 590        
 Pro Gly Gly Thr Gly Gly Gly Lys Ala Ser Val Gly Ala Met Gly Gly
         595                 600                 605            
 Gly Val Gly Ala Ser Ser Ser Gly Gly Gly Pro Gly Gly Ser Gly Gly
     610                 615                 620                
 Gly Gly Ser Gly Gly Pro Gly Ala Gly Thr Ser Phe Pro Pro Pro Gly
 625                 630                 635                 640
 Val Lys Leu Gly Arg Asp Ser Gly Lys Val Thr Thr Val Val Ala Thr
                 645                 650                 655    
 Leu Gly Gln Gly Pro Glu Arg Ser Gln Glu Val Ala Tyr Thr Asp Ile
             660                 665                 670        
 Lys Val Ile Gly Asn Gly Ser Phe Gly Val Val Tyr Gln Ala Arg Leu
         675                 680                 685            
 Ala Glu Thr Arg Glu Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys
     690                 695                 700                
 Arg Phe Lys Asn Arg Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys
 705                 710                 715                 720
 Asn Ile Val Arg Leu Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys
                 725                 730                 735    
 Asp Glu Leu Tyr Leu Asn Leu Val Leu Glu Tyr Val Pro Glu Thr Val
             740                 745                 750        
 Tyr Arg Val Ala Arg His Phe Thr Lys Ala Lys Leu Thr Ile Pro Ile
         755                 760                 765            
 Leu Tyr Val Lys Val Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr
     770                 775                 780                
 Ile His Ser Gln Gly Val Cys His Arg Asp Ile Lys Pro Gln Asn Leu
 785                 790                 795                 800
 Leu Val Asp Pro Asp Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Gly
                 805                 810                 815    
 Ala Lys Gln Leu Val Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser
             820                 825                 830        
 Arg Tyr Tyr Arg Ala Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr
         835                 840                 845            
 Ser Ser Ile Asp Val Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu
     850                 855                 860                
 Leu Gly Gln Pro Ile Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val
 865                 870                 875                 880
 Glu Ile Ile Lys Val Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu
                 885                 890                 895    
 Met Asn Pro Asn Tyr Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His
             900                 905                 910        
 Pro Trp Thr Lys Val Phe Lys Ser Arg Thr Pro Pro Glu Ala Ile Ala
         915                 920                 925            
 Leu Cys Ser Ser Leu Leu Glu Tyr Thr Pro Ser Ser Arg Leu Ser Pro
     930                 935                 940                
 Leu Glu Ala Cys Ala His Ser Phe Phe Asp Glu Leu Arg Cys Leu Gly
 945                 950                 955                 960
 Thr Gln Leu Pro Asn Asn Arg Pro Leu Pro Pro Leu Phe Asn Phe Ser
                 965                 970                 975    
 Ala Gly Glu Leu Ser Ile Gln Pro Ser Leu Asn Ala Ile Leu Ile Pro
             980                 985                 990        
 Pro His Leu Arg Ser Pro Ala Gly Thr Thr Thr Leu Thr Pro Ser Ser
         995                1000                1005            
 Gln Ala Leu Thr Glu Thr Pro Thr Ser Ser Asp Trp Gln Ser Thr Asp
    1010                1015                1020                
 Ala Thr Pro Thr Leu Thr Asn Ser Ser
1025                1030            



      <210> 873
      <211> 1108
      <212> PRT
      <213> Homo sapiens


      <400> 873
 Met Lys Thr Pro Ala Asp Thr Gly Phe Ala Phe Pro Asp Trp Ala Tyr
   1               5                  10                  15    
 Lys Pro Glu Ser Ser Pro Gly Ser Arg Gln Ile Gln Leu Trp His Phe
              20                  25                  30        
 Ile Leu Glu Leu Leu Arg Lys Glu Glu Tyr Gln Gly Val Ile Ala Trp
          35                  40                  45            
 Gln Gly Asp Tyr Gly Glu Phe Val Ile Lys Asp Pro Asp Glu Val Ala
      50                  55                  60                
 Arg Leu Trp Gly Val Arg Lys Cys Lys Pro Gln Met Asn Tyr Asp Lys
  65                  70                  75                  80
 Leu Ser Arg Ala Leu Arg Tyr Tyr Tyr Asn Lys Arg Ile Leu His Lys
                  85                  90                  95    
 Thr Lys Gly Lys Arg Phe Thr Tyr Lys Phe Asn Phe Asn Lys Leu Val
             100                 105                 110        
 Leu Val Asn Tyr Pro Phe Ile Asp Val Gly Leu Ala Gly Gly Ala Val
         115                 120                 125            
 Pro Gln Ser Ala Pro Pro Val Pro Ser Gly Gly Ser His Phe Arg Phe
     130                 135                 140                
 Pro Pro Ser Thr Pro Ser Glu Val Leu Ser Pro Thr Glu Asp Pro Arg
 145                 150                 155                 160
 Ser Pro Pro Ala Cys Ser Ser Ser Ser Ser Ser Leu Phe Ser Ala Val
                 165                 170                 175    
 Val Ala Arg Arg Leu Gly Arg Gly Ser Val Ser Asp Cys Ser Asp Gly
             180                 185                 190        
 Thr Ser Glu Leu Glu Glu Pro Leu Gly Glu Asp Pro Arg Ala Arg Pro
         195                 200                 205            
 Pro Gly Pro Pro Asp Leu Gly Ala Phe Arg Gly Pro Pro Leu Ala Arg
     210                 215                 220                
 Leu Pro His Asp Pro Gly Val Phe Arg Val Tyr Pro Arg Pro Arg Gly
 225                 230                 235                 240
 Gly Pro Glu Pro Leu Ser Pro Phe Pro Val Ser Pro Leu Ala Gly Pro
                 245                 250                 255    
 Gly Ser Leu Leu Pro Pro Gln Leu Ser Pro Ala Leu Pro Met Thr Pro
             260                 265                 270        
 Thr His Leu Ala Tyr Thr Pro Ser Pro Thr Leu Ser Pro Met Tyr Pro
         275                 280                 285            
 Ser Gly Gly Gly Gly Pro Ser Gly Ser Gly Gly Gly Ser His Phe Ser
     290                 295                 300                
 Phe Ser Pro Glu Asp Met Lys Arg Tyr Leu Gln Ala His Thr Gln Ser
 305                 310                 315                 320
 Val Tyr Asn Tyr His Leu Ser Pro Arg Ala Phe Leu His Tyr Pro Gly
                 325                 330                 335    
 Leu Val Val Pro Gln Pro Gln Arg Pro Asp Lys Cys Pro Leu Pro Pro
             340                 345                 350        
 Met Ala Pro Glu Thr Pro Pro Val Pro Ser Ser Ala Ser Ser Ser Ser
         355                 360                 365            
 Ser Ser Ser Ser Ser Pro Phe Lys Phe Lys Leu Gln Pro Pro Pro Leu
     370                 375                 380                
 Gly Arg Arg Gln Arg Ala Ala Gly Glu Lys Ala Val Ala Gly Ala Asp
 385                 390                 395                 400
 Lys Ser Gly Gly Ser Ala Gly Gly Leu Ala Glu Gly Ala Gly Ala Leu
                 405                 410                 415    
 Ala Pro Pro Pro Pro Pro Pro Gln Ile Lys Val Glu Pro Ile Ser Glu
             420                 425                 430        
 Gly Glu Ser Glu Glu Val Glu Val Thr Asp Ile Ser Asp Glu Asp Glu
         435                 440                 445            
 Glu Asp Gly Glu Val Phe Lys Thr Pro Arg Ala Pro Pro Ala Pro Pro
     450                 455                 460                
 Lys Pro Glu Pro Gly Glu Ala Pro Gly Ala Ser Gln Cys Met Pro Leu
 465                 470                 475                 480
 Lys Leu Arg Phe Lys Arg Arg Trp Ser Glu Asp Cys Arg Leu Glu Gly
                 485                 490                 495    
 Gly Gly Gly Pro Ala Gly Gly Phe Glu Asp Glu Gly Glu Asp Lys Lys
             500                 505                 510        
 Ser Ala Asp Arg Leu Pro Trp Thr Pro Phe Pro Asp Val Gln Arg Asp
         515                 520                 525            
 Pro Ser Phe Pro Pro Ile Ile Pro Ala Val Tyr Ser Glu Ala Phe Val
     530                 535                 540                
 Asp Phe Ile Ser Arg Arg Ala Thr Arg Leu Ser Val Arg Ala Glu Gly
 545                 550                 555                 560
 Gly Asp Gly Gly Ala Asp Asp Ser Arg Thr Ala Ser Pro Gly Val Pro
                 565                 570                 575    
 Arg Gly Gly Arg Trp Ala Gly Ala Gly Ala Gln Ala Arg Ala Ala Arg
             580                 585                 590        
 Pro Gly Arg Gly Gln Gly Pro Gly Glu Ala Ala Ala Ala Ala Ala Ala
         595                 600                 605            
 Gly Ala Ala Arg Ala Ala Arg Ala Pro Gln Pro Gly Pro Val Leu Gly
     610                 615                 620                
 Ala Met Ser Gly Gly Gly Pro Ser Gly Gly Gly Pro Gly Gly Ser Gly
 625                 630                 635                 640
 Arg Ala Arg Thr Ser Ser Phe Ala Glu Pro Gly Gly Gly Gly Gly Gly
                 645                 650                 655    
 Gly Gly Gly Gly Pro Gly Gly Ser Ala Ser Gly Pro Gly Gly Thr Gly
             660                 665                 670        
 Gly Gly Lys Ala Ser Val Gly Ala Met Gly Gly Gly Val Gly Ala Ser
         675                 680                 685            
 Ser Ser Gly Gly Gly Pro Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
     690                 695                 700                
 Pro Gly Ala Gly Thr Ser Phe Pro Pro Pro Gly Val Lys Leu Gly Arg
 705                 710                 715                 720
 Asp Ser Gly Lys Val Thr Thr Val Val Ala Thr Leu Gly Gln Gly Pro
                 725                 730                 735    
 Glu Arg Ser Gln Glu Val Ala Tyr Thr Asp Ile Lys Val Ile Gly Asn
             740                 745                 750        
 Gly Ser Phe Gly Val Val Tyr Gln Ala Arg Leu Ala Glu Thr Arg Glu
         755                 760                 765            
 Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg
     770                 775                 780                
 Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu
 785                 790                 795                 800
 Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Leu Tyr Leu
                 805                 810                 815    
 Asn Leu Val Leu Glu Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg
             820                 825                 830        
 His Phe Thr Lys Ala Lys Leu Thr Ile Pro Ile Leu Tyr Val Lys Val
         835                 840                 845            
 Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Gln Gly
     850                 855                 860                
 Val Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Val Asp Pro Asp
 865                 870                 875                 880
 Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Gly Ala Lys Gln Leu Val
                 885                 890                 895    
 Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala
             900                 905                 910        
 Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val
         915                 920                 925            
 Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile
     930                 935                 940                
 Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val
 945                 950                 955                 960
 Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr
                 965                 970                 975    
 Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val
             980                 985                 990        
 Phe Lys Ser Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Ser Leu
         995                1000                1005            
 Leu Glu Tyr Thr Pro Ser Ser Arg Leu Ser Pro Leu Glu Ala Cys Ala
    1010                1015                1020                
 His Ser Phe Phe Asp Glu Leu Arg Cys Leu Gly Thr Gln Leu Pro Asn
1025                1030                1035                1040
 Asn Arg Pro Leu Pro Pro Leu Phe Asn Phe Ser Ala Gly Glu Leu Ser
                1045                1050                1055    
 Ile Gln Pro Ser Leu Asn Ala Ile Leu Ile Pro Pro His Leu Arg Ser
            1060                1065                1070        
 Pro Ala Gly Thr Thr Thr Leu Thr Pro Ser Ser Gln Ala Leu Thr Glu
        1075                1080                1085            
 Thr Pro Thr Ser Ser Asp Trp Gln Ser Thr Asp Ala Thr Pro Thr Leu
    1090                1095                1100                
 Thr Asn Ser Ser
1105            



      <210> 874
      <211> 161
      <212> PRT
      <213> Homo sapiens


      <400> 874
 Met Ala Gly Arg Lys Leu Ala Leu Lys Thr Ile Asp Trp Val Ser Phe
   1               5                  10                  15    
 Val Glu Val Met Pro Gln Asn Gln Lys Ala Ile Gly Asn Ala Leu Lys
              20                  25                  30        
 Ser Trp Asn Glu Thr Phe His Ala Arg Leu Ala Ser Leu Ser Glu Lys
          35                  40                  45            
 Pro Pro Ala Ile Asp Trp Ala Tyr Tyr Arg Ala Asn Val Ala Lys Pro
      50                  55                  60                
 Gly Leu Val Asp Asp Phe Glu Lys Lys Tyr Asn Ala Leu Lys Ile Pro
  65                  70                  75                  80
 Val Pro Glu Asp Lys Tyr Thr Ala Leu Val Asp Gln Glu Glu Lys Glu
                  85                  90                  95    
 Asp Val Lys Ser Cys Ala Glu Phe Val Ser Gly Ser Gln Leu Arg Ile
             100                 105                 110        
 Gln Glu Tyr Glu Lys Gln Leu Glu Lys Met Arg Asn Ile Ile Pro Phe
         115                 120                 125            
 Asp Gln Met Thr Ile Asp Asp Leu Asn Glu Ile Phe Pro Glu Thr Lys
     130                 135                 140                
 Leu Asp Lys Lys Lys Tyr Pro Tyr Trp Pro His Gln Pro Ile Glu Asn
 145                 150                 155                 160
 Leu
    



      <210> 875
      <211> 253
      <212> PRT
      <213> Homo sapiens


      <400> 875
 Met Ser Phe Ser Val His Asn Gln Lys Gly Ser Lys Arg Pro Leu Pro
   1               5                  10                  15    
 Leu Glu Pro Leu Leu Phe Leu Gln Val Pro Arg Ser Asn Tyr Leu His
              20                  25                  30        
 Phe Gln Glu Glu Lys Gln Arg Leu His Leu Lys Lys Phe Leu Leu Asp
          35                  40                  45            
 Arg Met Phe Leu Val Ala Lys Ile Gln Ala Asn Val Glu Arg Lys Asp
      50                  55                  60                
 Val Ala Asp Tyr Tyr Glu Gln Met Phe Gln Ser Val Leu Lys His His
  65                  70                  75                  80
 Leu Gly Glu Ala Val Thr Gly Leu Leu Leu Ile Tyr Pro Thr Ser Ile
                  85                  90                  95    
 Leu His Ile Leu Glu Ser Ser Ser Asp Thr Leu Tyr Lys Val Leu Leu
             100                 105                 110        
 Asp Tyr Ile Gly His Val Lys Asp Glu Thr Val Phe Phe Ile Gln Gln
         115                 120                 125            
 Met Lys Ile Ile Val Ile Ser His Asn Ile Pro Met Arg Leu Phe Met
     130                 135                 140                
 Gln Trp His Val Ser Val Ile Lys Val Pro Val Met Tyr Leu Asp Asp
 145                 150                 155                 160
 Val Thr Gln Ser Gln Ser Leu Lys Glu Val Ile Thr Asp Phe Leu Thr
                 165                 170                 175    
 Gln Thr His Lys Leu Ser Leu Tyr Leu Cys Gln Thr Met Lys Val Gly
             180                 185                 190        
 Thr Lys Gly Pro Gly Asp Asn Leu His Gln Val Ala Pro Asp Leu Leu
         195                 200                 205            
 Leu Pro Glu Gln Ile Ile Lys Tyr Leu Cys Lys Ser Glu Glu Phe Met
     210                 215                 220                
 Asp Pro Ala Thr Phe Ile Asn Met Tyr Asn Arg Pro Ile His Ile Thr
 225                 230                 235                 240
 Leu Asp Ser Glu Val Val Trp Pro Ala Pro Ser Arg Phe
                 245                 250            



      <210> 876
      <211> 118
      <212> PRT
      <213> Homo sapiens


      <400> 876
 Met Asn Pro Thr Asp His Thr Gln Leu Thr Pro Gln Leu Lys Glu His
   1               5                  10                  15    
 Gln Pro Tyr Gln Met Arg Lys Asn Gln His Lys Asn Ser Gly Asn Ser
              20                  25                  30        
 Lys Asn His Ser Val Pro Leu Pro Pro Asn Glu Ser Thr Ser Ser Pro
          35                  40                  45            
 Ala Met Val Leu Asn Gln Ser Glu Met Thr Glu Met Thr Asp Ile Glu
      50                  55                  60                
 Phe Arg Ile Trp Met Ala Lys Lys Leu Ile Glu Ile Gln Lys Lys Val
  65                  70                  75                  80
 Glu Thr Gln Ser Lys Glu Ser Lys Gln Ser Ser Lys Met Ile Gln Gly
                  85                  90                  95    
 Leu Lys Asp Glu Ile Ala Ile Val Arg Lys Asn Gln Ser Glu Leu Leu
             100                 105                 110        
 Lys Leu Lys Asn Ser Leu
         115            



      <210> 877
      <211> 81
      <212> PRT
      <213> Homo sapiens


      <400> 877
 Met Glu Gly Ala Gly Ala Gly Ser Gly Phe Arg Lys Glu Leu Val Ser
   1               5                  10                  15    
 Arg Leu Leu His Leu His Phe Lys Asp Asp Lys Thr Lys Val Ser Gly
              20                  25                  30        
 Asp Ala Leu Gln Leu Met Val Glu Leu Leu Lys Val Phe Val Val Glu
          35                  40                  45            
 Ala Ala Val Arg Gly Val Arg Gln Ala Gln Ala Glu Asp Ala Leu Arg
      50                  55                  60                
 Val Asp Val Asp Gln Leu Glu Lys Val Leu Pro Gln Leu Leu Leu Asp
  65                  70                  75                  80
 Phe
    



      <210> 878
      <211> 457
      <212> PRT
      <213> Homo sapiens


      <400> 878
 Met Met Glu Arg Arg Met Glu Cys Gly Ala Val Ile Met Asn Gly Cys
   1               5                  10                  15    
 Ile Tyr Val Thr Gly Gly Tyr Ser Tyr Ser Lys Gly Thr Tyr Leu Gln
              20                  25                  30        
 Ser Ile Glu Lys Tyr Asp Pro Asp Leu Asn Lys Trp Glu Ile Ile Ala
          35                  40                  45            
 Ala Met Ala Glu Asn Gly Asp Asn Glu Lys Met Ala Ala Leu Glu Ala
      50                  55                  60                
 Lys Ile Cys His Gln Ile Glu Tyr Tyr Phe Gly Asp Phe Asn Leu Pro
  65                  70                  75                  80
 Arg Asp Lys Phe Leu Lys Glu Gln Ile Lys Leu Asp Glu Gly Trp Val
                  85                  90                  95    
 Pro Leu Glu Ile Met Ile Lys Phe Asn Arg Leu Asn Arg Leu Thr Thr
             100                 105                 110        
 Asp Phe Asn Val Ile Val Glu Ala Leu Ser Lys Ser Lys Ala Glu Leu
         115                 120                 125            
 Met Glu Ile Ser Glu Asp Lys Thr Lys Ile Arg Arg Ser Pro Ser Lys
     130                 135                 140                
 Pro Leu Pro Glu Val Thr Asp Glu Tyr Lys Asn Asp Val Lys Asn Arg
 145                 150                 155                 160
 Ser Val Tyr Ile Lys Gly Phe Pro Thr Asp Ala Thr Leu Asp Asp Ile
                 165                 170                 175    
 Lys Glu Trp Leu Glu Asp Lys Gly Gln Val Leu Asn Ile Gln Met Arg
             180                 185                 190        
 Arg Thr Leu His Lys Ala Phe Lys Gly Ser Ile Phe Val Val Phe Asp
         195                 200                 205            
 Ser Ile Glu Ser Ala Lys Lys Phe Val Glu Thr Pro Gly Gln Lys Tyr
     210                 215                 220                
 Lys Glu Thr Asp Leu Leu Ile Leu Phe Lys Asp Asp Tyr Phe Ala Lys
 225                 230                 235                 240
 Lys Asn Glu Glu Arg Lys Gln Asn Lys Val Glu Ala Lys Leu Arg Ala
                 245                 250                 255    
 Lys Gln Glu Gln Glu Ala Lys Gln Lys Leu Glu Glu Asp Ala Glu Met
             260                 265                 270        
 Lys Ser Leu Glu Glu Lys Ile Gly Cys Leu Leu Lys Phe Ser Gly Asp
         275                 280                 285            
 Leu Asp Asp Gln Thr Cys Arg Glu Asp Leu His Ile Leu Phe Ser Asn
     290                 295                 300                
 His Gly Glu Ile Lys Trp Ile Asp Phe Val Arg Gly Ala Lys Glu Gly
 305                 310                 315                 320
 Ile Ile Leu Phe Lys Glu Lys Ala Lys Glu Ala Leu Gly Lys Ala Lys
                 325                 330                 335    
 Asp Ala Asn Asn Gly Asn Leu Gln Leu Arg Asn Lys Glu Val Thr Trp
             340                 345                 350        
 Glu Val Leu Glu Gly Glu Val Glu Lys Glu Ala Leu Lys Lys Ile Ile
         355                 360                 365            
 Glu Asp Gln Gln Glu Ser Leu Asn Lys Trp Lys Ser Lys Gly Arg Arg
     370                 375                 380                
 Phe Lys Gly Lys Gly Lys Gly Asn Lys Ala Ala Gln Pro Gly Ser Gly
 385                 390                 395                 400
 Lys Gly Lys Val Gln Phe Gln Gly Lys Lys Thr Lys Phe Ala Ser Asp
                 405                 410                 415    
 Asp Glu His Asp Glu His Asp Glu Asn Gly Ala Thr Gly Pro Val Lys
             420                 425                 430        
 Arg Ala Arg Glu Glu Thr Asp Lys Glu Glu Pro Ala Ser Lys Gln Gln
         435                 440                 445            
 Lys Thr Glu Asn Gly Ala Gly Asp Gln
     450                 455        



      <210> 879
      <211> 214
      <212> PRT
      <213> Homo sapiens


      <400> 879
 Met Gly Leu Met His Ile Ala Gln Gln Ser Gly Ala Ile Lys Trp Cys
   1               5                  10                  15    
 Gln Ser Ala Ile Val Arg Arg Asn Asp Gln Phe Pro Arg Glu Gly Leu
              20                  25                  30        
 Asp Lys Pro Pro Ile His Ile Tyr Asn Asp Phe Asp Thr Glu Glu Gln
          35                  40                  45            
 Arg Gly Asp Ile Val Gly Ala Tyr Val Thr Val Lys Thr Asp Asp Gly
      50                  55                  60                
 Asp Tyr Leu Thr His Thr Met Gly Ile Asp Ala Ile Tyr Ser Ile Arg
  65                  70                  75                  80
 Asp Arg Ser Glu Ala Trp Lys Lys Tyr Lys Ser Asp Asn Ser Lys Lys
                  85                  90                  95    
 Cys Pro Trp Val Thr Asp Glu Glu Gln Met Ile Leu Lys Thr Val Val
             100                 105                 110        
 Lys Gln Ala Ala Lys Tyr Trp Pro Arg Arg Glu Arg Leu Asp Ala Ala
         115                 120                 125            
 Ile Asp His Val Asn Thr Glu Gly Glu Glu Gly Ile Asn Phe Ser Ala
     130                 135                 140                
 Glu Arg Gln Pro Glu Arg Asp Val Thr Pro Ala Gly Asp Glu Ile Ile
 145                 150                 155                 160
 Lys Glu Ile Asn Asp Val Leu Ile Ala Met Asp Lys Thr Trp Glu Glu
                 165                 170                 175    
 Asn Leu Leu Pro Val Cys Ser Gln Ile Phe Arg Arg Asp Ile Arg Asp
             180                 185                 190        
 Ser Ser Glu Leu Thr Gln Ala Glu Ala Val Lys Ala Leu Gly Phe Leu
         195                 200                 205            
 Lys Lys Lys Ala Ala Ala
     210                



      <210> 880
      <211> 226
      <212> PRT
      <213> Homo sapiens


      <400> 880
 Met Asn Leu Glu Ser Ile Ala Lys Tyr Phe Ala Pro Lys Ser Pro Met
   1               5                  10                  15    
 Phe Ser Asp Ser Pro Arg Ala Thr Ala Ser Asp Ser Leu Thr Gly Thr
              20                  25                  30        
 Asp Val Met Ala Ala Leu Gly Leu Ala Gly His Lys Cys Gly Phe Gly
          35                  40                  45            
 Phe Asp Leu Tyr Leu Ser Lys Ile Gly Ile Ser Ser Pro Asp Ile Ala
      50                  55                  60                
 Leu Glu Arg Leu Tyr Glu Gln Ala Arg Lys Leu Ser Gly Lys Phe Arg
  65                  70                  75                  80
 Ala Leu Ser Glu Leu Asp Glu Ser Ala Arg Ser Gly Val Leu Lys Val
                  85                  90                  95    
 Leu Cys Ala Phe Ala Tyr Gln Asp Tyr Ser Arg Ser Ala Ala Ser Thr
             100                 105                 110        
 Arg Lys Cys Asp Cys Cys Asp Gly Gly Gly Phe Thr Glu Ala Gln Val
         115                 120                 125            
 Phe Thr Asn Lys Val Ser Tyr Pro Trp Gly Lys Pro Pro Tyr Trp Ser
     130                 135                 140                
 Lys Met Ser Arg Ala Val Arg Pro Ser Asp Trp Glu Ser Trp Thr Gln
 145                 150                 155                 160
 Ala Arg Glu Val Val Arg Val Lys Cys Lys Pro Cys Asn Gly Lys Gly
                 165                 170                 175    
 Val Ile Ser Asn Ser Cys Arg Cys His Gly Lys Gly Lys Val Leu Asp
             180                 185                 190        
 Lys Ala Glu Ser Asp Arg Gln Gly Val Pro Val Met Lys Ala Cys Asp
         195                 200                 205            
 Arg Cys Gly Gly Arg Gly Tyr Ala Arg Leu Lys Phe Ser Thr Val Leu
     210                 215                 220                
 Arg Gly
 225    



      <210> 881
      <211> 446
      <212> PRT
      <213> Homo sapiens


      <400> 881
 Met Ser Ala Glu Ala Gly Gly Gly Trp Trp Ala Thr Gly Arg Ile Leu
   1               5                  10                  15    
 Ile Ala Val Arg Arg Pro Tyr Leu Gly Pro Gly Leu Thr Pro Ala Ala
              20                  25                  30        
 Leu Pro Ala Pro Pro Ser Ser Ile Met Ala Ser Pro Arg Thr Arg Lys
          35                  40                  45            
 Val Leu Lys Glu Val Arg Val Gln Asp Glu Asn Asn Val Cys Phe Glu
      50                  55                  60                
 Cys Gly Ala Phe Asn Pro Gln Trp Val Ser Val Thr Tyr Gly Ile Trp
  65                  70                  75                  80
 Ile Cys Leu Glu Cys Ser Gly Arg His Arg Gly Leu Gly Val His Leu
                  85                  90                  95    
 Ser Phe Val Arg Ser Val Thr Met Asp Lys Trp Lys Asp Ile Glu Leu
             100                 105                 110        
 Glu Lys Met Lys Ala Gly Gly Asn Ala Lys Phe Arg Glu Phe Leu Glu
         115                 120                 125            
 Ser Gln Glu Asp Tyr Asp Pro Cys Trp Ser Leu Gln Glu Lys Tyr Asn
     130                 135                 140                
 Ser Arg Ala Ala Ala Leu Phe Arg Asp Lys Val Val Ala Leu Ala Glu
 145                 150                 155                 160
 Gly Arg Glu Trp Ser Leu Glu Ser Ser Pro Ala Gln Asn Trp Thr Pro
                 165                 170                 175    
 Pro Gln Pro Arg Thr Leu Pro Ser Met Val His Arg Val Ser Gly Gln
             180                 185                 190        
 Pro Gln Ser Val Thr Ala Ser Ser Asp Lys Ala Phe Glu Asp Trp Leu
         195                 200                 205            
 Asn Asp Asp Leu Gly Ser Tyr Gln Gly Ala Gln Gly Asn Arg Tyr Val
     210                 215                 220                
 Gly Phe Gly Asn Thr Pro Pro Pro Gln Lys Lys Glu Asp Asp Phe Leu
 225                 230                 235                 240
 Asn Asn Ala Met Ser Ser Leu Tyr Ser Gly Trp Ser Ser Phe Thr Thr
                 245                 250                 255    
 Gly Ala Ser Arg Phe Ala Ser Ala Ala Lys Glu Gly Ala Thr Lys Phe
             260                 265                 270        
 Gly Ser Gln Ala Ser Gln Lys Ala Ser Glu Leu Gly His Ser Leu Asn
         275                 280                 285            
 Glu Asn Val Leu Lys Pro Ala Gln Glu Lys Val Lys Glu Gly Lys Ile
     290                 295                 300                
 Phe Asp Asp Val Ser Ser Gly Val Ser Gln Leu Ala Ser Lys Val Gln
 305                 310                 315                 320
 Gly Val Gly Ser Lys Gly Trp Arg Asp Val Thr Thr Phe Phe Ser Gly
                 325                 330                 335    
 Lys Ala Glu Gly Pro Leu Asp Ser Pro Ser Glu Gly His Ser Tyr Gln
             340                 345                 350        
 Asn Ser Gly Leu Asp His Phe Gln Asn Ser Asn Ile Asp Gln Ser Phe
         355                 360                 365            
 Trp Glu Thr Phe Gly Ser Ala Glu Pro Thr Lys Thr Arg Lys Ser Pro
     370                 375                 380                
 Ser Ser Asp Ser Trp Thr Cys Ala Asp Thr Ser Thr Glu Arg Arg Ser
 385                 390                 395                 400
 Ser Asp Ser Trp Glu Val Trp Gly Ser Ala Ser Thr Asn Arg Asn Ser
                 405                 410                 415    
 Asn Ser Asp Gly Gly Glu Gly Gly Glu Gly Thr Lys Lys Ala Val Pro
             420                 425                 430        
 Pro Ala Val Pro Thr Asp Asp Gly Trp Asp Asn Gln Asn Trp
         435                 440                 445    



      <210> 882
      <211> 807
      <212> PRT
      <213> Homo sapiens


      <400> 882
 Met Glu Glu Glu Leu Lys Cys Pro Val Cys Gly Ser Leu Phe Arg Glu
   1               5                  10                  15    
 Pro Ile Ile Leu Pro Cys Ser His Asn Val Cys Leu Pro Cys Ala Arg
              20                  25                  30        
 Thr Ile Ala Val Gln Thr Pro Asp Gly Glu Gln His Leu Pro Gln Pro
          35                  40                  45            
 Leu Leu Leu Ser Arg Gly Ser Gly Leu Gln Ala Gly Ala Ala Ala Ala
      50                  55                  60                
 Ala Ser Leu Glu His Asp Ala Ala Ala Gly Pro Ala Cys Gly Gly Ala
  65                  70                  75                  80
 Gly Gly Ser Ala Ala Gly Gly Leu Gly Gly Gly Ala Gly Gly Gly Gly
                  85                  90                  95    
 Asp His Ala Asp Lys Leu Ser Leu Tyr Ser Glu Thr Asp Ser Gly Tyr
             100                 105                 110        
 Gly Ser Tyr Thr Pro Ser Leu Lys Ser Pro Asn Gly Val Arg Val Leu
         115                 120                 125            
 Pro Met Val Pro Ala Pro Pro Gly Ser Ser Ala Ala Ala Ala Arg Gly
     130                 135                 140                
 Ala Ala Cys Ser Ser Leu Ser Ser Ser Ser Ser Ser Ile Thr Cys Pro
 145                 150                 155                 160
 Gln Cys His Arg Ser Ala Ser Leu Asp His Arg Gly Leu Arg Gly Phe
                 165                 170                 175    
 Gln Arg Asn Arg Leu Leu Glu Ala Ile Val Gln Arg Tyr Gln Gln Gly
             180                 185                 190        
 Arg Gly Ala Val Pro Gly Thr Ser Ala Ala Ala Ala Val Ala Ile Cys
         195                 200                 205            
 Gln Leu Cys Asp Arg Thr Pro Pro Glu Pro Ala Ala Thr Leu Cys Glu
     210                 215                 220                
 Gln Cys Asp Val Leu Tyr Cys Ser Ala Cys Gln Leu Lys Cys His Pro
 225                 230                 235                 240
 Ser Arg Gly Pro Phe Ala Lys His Arg Leu Val Gln Pro Pro Pro Pro
                 245                 250                 255    
 Pro Pro Pro Pro Ala Glu Ala Ala Ser Gly Pro Thr Gly Thr Ala Gln
             260                 265                 270        
 Gly Ala Pro Ser Gly Gly Gly Gly Cys Lys Ser Pro Gly Gly Ala Gly
         275                 280                 285            
 Ala Gly Ala Thr Gly Gly Ser Thr Ala Arg Lys Phe Pro Thr Cys Pro
     290                 295                 300                
 Glu His Glu Met Glu Asn Tyr Ser Met Tyr Cys Val Ser Cys Arg Thr
 305                 310                 315                 320
 Pro Val Cys Tyr Leu Cys Leu Glu Glu Gly Arg His Ala Lys His Glu
                 325                 330                 335    
 Val Lys Pro Leu Gly Ala Met Trp Lys Gln His Lys Ala Gln Leu Ser
             340                 345                 350        
 Gln Ala Leu Asn Gly Val Ser Asp Lys Ala Lys Glu Ala Lys Glu Phe
         355                 360                 365            
 Leu Val Gln Leu Lys Asn Ile Leu Gln Gln Ile Gln His Ser Pro Asp
     370                 375                 380                
 Phe Ser Ile Phe Pro Leu Lys Leu Phe Ala Ser Ser Gln Pro Thr Pro
 385                 390                 395                 400
 Asn Leu Cys Gln Glu Asn Gly Leu Asp Tyr Glu Ala Cys Leu Val Ala
                 405                 410                 415    
 Gln Cys Asp Ala Leu Val Asp Ala Leu Thr Arg Gln Lys Ala Lys Leu
             420                 425                 430        
 Leu Thr Lys Val Thr Lys Glu Arg Glu His Lys Leu Lys Met Val Trp
         435                 440                 445            
 Asp Gln Ile Asn His Cys Thr Leu Lys Leu Arg Gln Ser Thr Gly Leu
     450                 455                 460                
 Met Glu Tyr Cys Leu Glu Val Ile Lys Glu Asn Asp Pro Ser Gly Phe
 465                 470                 475                 480
 Leu Gln Ile Ser Asp Ala Leu Ile Lys Arg Val Gln Val Ser Gln Glu
                 485                 490                 495    
 Gln Trp Val Lys Gly Ala Leu Glu Pro Lys Val Ser Ala Glu Phe Asp
             500                 505                 510        
 Leu Thr Leu Asp Ser Glu Pro Leu Leu Gln Ala Ile His Gln Leu Asp
         515                 520                 525            
 Phe Ile Gln Met Lys Cys Arg Val Pro Pro Val Pro Leu Leu Gln Leu
     530                 535                 540                
 Glu Lys Cys Cys Thr Arg Asn Asn Ser Val Thr Leu Ala Trp Arg Met
 545                 550                 555                 560
 Pro Pro Phe Thr His Ser Pro Val Asp Gly Tyr Ile Leu Glu Leu Asp
                 565                 570                 575    
 Asp Gly Ala Gly Gly Gln Phe Arg Glu Val Tyr Val Gly Lys Glu Thr
             580                 585                 590        
 Leu Cys Thr Ile Asp Gly Leu His Phe Asn Ser Thr Tyr Asn Ala Arg
         595                 600                 605            
 Val Lys Ala Phe Asn Ser Ser Gly Val Gly Pro Tyr Ser Lys Thr Val
     610                 615                 620                
 Val Leu Gln Thr Ser Asp Val Ala Trp Phe Thr Phe Asp Pro Asn Ser
 625                 630                 635                 640
 Gly His Arg Asp Ile Ile Leu Ser Asn Asp Asn Gln Thr Ala Thr Cys
                 645                 650                 655    
 Ser Ser Tyr Asp Asp Arg Val Val Leu Gly Thr Ala Ala Phe Ser Lys
             660                 665                 670        
 Gly Val His Tyr Trp Glu Leu His Val Asp Arg Tyr Asp Asn His Pro
         675                 680                 685            
 Asp Pro Ala Phe Gly Val Ala Arg Ala Ser Val Val Lys Asp Met Met
     690                 695                 700                
 Leu Gly Lys Asp Asp Lys Ala Trp Ala Met Tyr Val Asp Asn Asn Arg
 705                 710                 715                 720
 Ser Trp Phe Met His Cys Asn Ser His Thr Asn Arg Thr Glu Gly Gly
                 725                 730                 735    
 Val Cys Lys Gly Ala Thr Val Gly Val Leu Leu Asp Leu Asn Lys His
             740                 745                 750        
 Thr Leu Thr Phe Phe Ile Asn Gly Gln Gln Gln Gly Pro Thr Ala Phe
         755                 760                 765            
 Ser His Val Asp Gly Val Phe Met Pro Ala Leu Ser Leu Asn Arg Asn
     770                 775                 780                
 Val Gln Val Thr Leu His Thr Gly Leu Glu Val Pro Thr Asn Leu Gly
 785                 790                 795                 800
 Arg Pro Lys Leu Ser Gly Asn
                 805        



      <210> 883
      <211> 576
      <212> PRT
      <213> Homo sapiens


      <400> 883
 Met Ser Lys Arg Gly Met Ser Ser Arg Ala Lys Gly Asp Lys Ala Glu
   1               5                  10                  15    
 Ala Leu Ala Ala Leu Gln Ala Ala Asn Glu Asp Leu Arg Ala Lys Leu
              20                  25                  30        
 Thr Asp Ile Gln Ile Glu Leu Gln Gln Glu Lys Ser Lys Val Ser Lys
          35                  40                  45            
 Val Glu Arg Glu Lys Asn Gln Glu Leu Arg Gln Val Arg Glu His Glu
      50                  55                  60                
 Gln His Lys Thr Ala Val Leu Leu Thr Glu Leu Lys Thr Lys Leu His
  65                  70                  75                  80
 Glu Glu Lys Met Lys Glu Leu Gln Ala Val Arg Glu Thr Leu Leu Arg
                  85                  90                  95    
 Gln His Glu Ala Glu Leu Leu Arg Val Ile Lys Ile Lys Asp Asn Glu
             100                 105                 110        
 Asn Gln Arg Leu Gln Ala Leu Leu Ser Ala Leu Arg Asp Gly Gly Pro
         115                 120                 125            
 Glu Lys Val Lys Thr Val Leu Leu Ser Glu Ala Lys Glu Glu Ala Lys
     130                 135                 140                
 Lys Gly Phe Glu Val Glu Lys Val Lys Met Gln Gln Glu Ile Ser Glu
 145                 150                 155                 160
 Leu Lys Gly Ala Lys Arg Gln Val Glu Glu Ala Leu Thr Leu Val Ile
                 165                 170                 175    
 Gln Ala Asp Lys Ile Lys Ala Ala Glu Ile Arg Ser Val Tyr His Leu
             180                 185                 190        
 His Gln Glu Glu Ile Thr Arg Ile Lys Lys Glu Cys Glu Arg Glu Ile
         195                 200                 205            
 Arg Arg Leu Met Glu Glu Ile Lys Phe Lys Asp Arg Ala Val Phe Val
     210                 215                 220                
 Leu Glu Arg Glu Leu Gly Val Gln Ala Gly His Ala Gln Arg Leu Gln
 225                 230                 235                 240
 Leu Gln Lys Glu Ala Leu Asp Glu Gln Leu Ser Gln Val Arg Glu Ala
                 245                 250                 255    
 Asp Arg His Pro Gly Ser Pro Arg Arg Glu Leu Pro His Ala Ala Gly
             260                 265                 270        
 Ala Gly Asp Ala Ser Asp His Ser Gly Ser Pro Glu Gln Gln Leu Asp
         275                 280                 285            
 Glu Lys Asp Ala Arg Arg Phe Gln Leu Lys Ile Ala Glu Leu Ser Ala
     290                 295                 300                
 Ile Ile Arg Lys Leu Glu Asp Arg Asn Ala Leu Leu Ser Glu Glu Arg
 305                 310                 315                 320
 Asn Glu Leu Leu Lys Arg Val Arg Glu Ala Glu Ser Gln Tyr Lys Pro
                 325                 330                 335    
 Leu Leu Asp Lys Asn Lys Arg Leu Ser Arg Lys Asn Glu Asp Leu Ser
             340                 345                 350        
 His Ala Leu Arg Arg Met Glu Asn Lys Leu Lys Phe Val Thr Gln Glu
         355                 360                 365            
 Asn Ile Glu Met Arg Gln Arg Ala Gly Ile Ile Arg Arg Pro Ser Ser
     370                 375                 380                
 Leu Asn Asp Leu Asp Gln Ser Gln Asp Glu Arg Glu Val Asp Phe Leu
 385                 390                 395                 400
 Lys Leu Gln Ile Val Glu Gln Gln Asn Leu Ile Asp Glu Leu Ser Lys
                 405                 410                 415    
 Thr Leu Glu Thr Ala Gly Tyr Val Lys Ser Val Leu Glu Arg Asp Lys
             420                 425                 430        
 Leu Leu Arg Phe Arg Lys Gln Arg Lys Lys Met Ala Lys Leu Pro Lys
         435                 440                 445            
 Pro Val Val Val Glu Thr Phe Phe Gly Tyr Asp Glu Glu Ala Ser Leu
     450                 455                 460                
 Glu Ser Asp Gly Ser Ser Val Ser Tyr Gln Thr Asp Arg Thr Asp Gln
 465                 470                 475                 480
 Thr Pro Cys Thr Pro Asp Asp Asp Leu Glu Glu Gly Met Ala Lys Glu
                 485                 490                 495    
 Glu Thr Glu Leu Arg Phe Arg Gln Leu Thr Met Glu Tyr Gln Ala Leu
             500                 505                 510        
 Gln Arg Ala Tyr Ala Leu Leu Gln Glu Gln Val Gly Gly Thr Leu Asp
         515                 520                 525            
 Ala Glu Arg Glu Val Lys Val Tyr Val Thr Ser Thr Ala Arg Ser Gly
     530                 535                 540                
 Pro Pro Ser Pro Gly Gly Ala His Gly Ser Arg Ser Lys Pro Gly Ile
 545                 550                 555                 560
 Gly Asp Pro Gly Asp Gly Ser Trp Pro Arg Pro Ser Leu Cys Cys Phe
                 565                 570                 575    





      <210> 884
      <211> 251
      <212> PRT
      <213> Homo sapiens


      <400> 884
 Met Pro Arg Phe Ala Ser Pro Leu Leu Arg Asn Val Ile Ile Arg Ser
   1               5                  10                  15    
 Gln Phe Asp Gly Ile Lys Arg Lys Gln Cys Leu Gln Tyr Leu Lys Thr
              20                  25                  30        
 Leu Arg Thr Leu Gln Tyr Asp Gly Phe Lys Thr Val Tyr Phe Gly Glu
          35                  40                  45            
 Thr Asn Ile Pro Glu Ser Leu Val Thr Gly Glu Asp Ile Ser Asp Gly
      50                  55                  60                
 Tyr Phe Ile Gln Thr Pro Thr Trp Cys Ile Val His Ala Ala Gly Ser
  65                  70                  75                  80
 Gln Gly Trp Val Pro Trp Lys Tyr Arg Val Phe Leu Arg Asp Glu Leu
                  85                  90                  95    
 Cys Ile Lys Gln Glu Asp Ser Leu Phe Ser Glu Phe Cys Asp Val Val
             100                 105                 110        
 Arg Lys Ala Tyr Gly Lys Cys Val Ile Val Val Lys Glu Arg Arg Gln
         115                 120                 125            
 Gln Glu Glu Gln Arg Pro Lys Glu Asp Arg Glu Ala Glu Gly Gln Phe
     130                 135                 140                
 Tyr Ile Pro Thr Val Ile Ser Leu Ala Ser Ile Met Cys Cys Pro Glu
 145                 150                 155                 160
 Val Ala Lys Ser Cys Gly His Glu Leu Leu Ser Leu Pro Ser Pro Cys
                 165                 170                 175    
 Asn Tyr Leu Asn Pro Leu Asp Ser Ala Trp Ser Ser Leu Lys Trp Phe
             180                 185                 190        
 Ile Ile Asn Asn Arg Asn Glu Phe Cys Leu Gln Ser Ile Asp Ser Gly
         195                 200                 205            
 Tyr Ser Tyr Gln Cys Ile Leu Phe Ser Asn Leu Ile Ser Lys Gly Ile
     210                 215                 220                
 Glu Arg Ile Asn Ala Ser Lys Trp Arg Thr Leu Thr Ser Lys Val Arg
 225                 230                 235                 240
 Arg Trp Glu Asn Tyr Tyr Leu Gly Lys Phe Ser
                 245                 250    



      <210> 885
      <211> 1684
      <212> PRT
      <213> Homo sapiens


      <400> 885
 Met Glu Asp Leu Val Gln Asp Gly Val Ala Ser Pro Ala Thr Pro Gly
   1               5                  10                  15    
 Thr Gly Lys Ser Lys Leu Glu Thr Leu Pro Lys Glu Asp Leu Ile Lys
              20                  25                  30        
 Phe Ala Lys Lys Gln Met Met Leu Ile Gln Lys Ala Lys Ser Arg Cys
          35                  40                  45            
 Thr Glu Leu Glu Lys Glu Ile Glu Glu Leu Arg Ser Lys Pro Val Thr
      50                  55                  60                
 Glu Gly Thr Gly Asp Ile Ile Lys Ala Leu Thr Glu Arg Leu Asp Ala
  65                  70                  75                  80
 Leu Leu Leu Glu Lys Ala Glu Thr Glu Gln Gln Cys Leu Ser Leu Lys
                  85                  90                  95    
 Lys Glu Asn Ile Lys Met Lys Gln Glu Val Glu Asp Ser Val Thr Lys
             100                 105                 110        
 Met Gly Asp Ala His Lys Glu Leu Glu Gln Ser His Ile Asn Tyr Val
         115                 120                 125            
 Lys Glu Ile Glu Asn Leu Lys Asn Glu Leu Met Ala Val Arg Ser Lys
     130                 135                 140                
 Tyr Ser Glu Asp Lys Ala Asn Leu Gln Lys Gln Leu Glu Glu Ala Met
 145                 150                 155                 160
 Asn Thr Gln Leu Glu Leu Ser Glu Gln Leu Lys Phe Gln Asn Asn Ser
                 165                 170                 175    
 Glu Asp Asn Val Lys Lys Leu Gln Glu Glu Ile Glu Lys Ile Arg Pro
             180                 185                 190        
 Gly Phe Glu Glu Gln Ile Leu Tyr Leu Gln Lys Gln Leu Asp Ala Thr
         195                 200                 205            
 Thr Asp Glu Lys Lys Glu Thr Val Thr Gln Leu Gln Asn Ile Ile Glu
     210                 215                 220                
 Ala Asn Ser Gln His Tyr Gln Lys Asn Ile Asn Ser Leu Gln Glu Glu
 225                 230                 235                 240
 Leu Leu Gln Leu Lys Ala Ile His Gln Glu Glu Val Lys Glu Leu Met
                 245                 250                 255    
 Cys Gln Ile Glu Ala Ser Ala Lys Glu His Glu Ala Glu Ile Asn Lys
             260                 265                 270        
 Leu Asn Glu Leu Lys Glu Asn Leu Val Lys Gln Cys Glu Ala Ser Glu
         275                 280                 285            
 Lys Asn Ile Gln Lys Lys Tyr Glu Cys Glu Leu Glu Asn Leu Arg Lys
     290                 295                 300                
 Ala Thr Ser Asn Ala Asn Gln Asp Asn Gln Ile Cys Ser Ile Leu Leu
 305                 310                 315                 320
 Gln Glu Asn Thr Phe Val Glu Gln Val Val Asn Glu Lys Val Lys His
                 325                 330                 335    
 Leu Glu Asp Thr Leu Lys Glu Leu Glu Ser Gln His Ser Ile Leu Lys
             340                 345                 350        
 Asp Glu Val Thr Tyr Met Asn Asn Leu Lys Leu Lys Leu Glu Met Asp
         355                 360                 365            
 Ala Gln His Ile Lys Asp Glu Phe Phe His Glu Arg Glu Asp Leu Glu
     370                 375                 380                
 Phe Lys Ile Asn Glu Leu Leu Leu Ala Lys Glu Glu Gln Gly Cys Val
 385                 390                 395                 400
 Ile Glu Lys Leu Lys Ser Glu Leu Ala Gly Leu Asn Lys Gln Phe Cys
                 405                 410                 415    
 Tyr Thr Val Glu Gln His Asn Arg Glu Val Gln Ser Leu Lys Glu Gln
             420                 425                 430        
 His Gln Lys Glu Ile Ser Glu Leu Asn Glu Thr Phe Leu Ser Asp Ser
         435                 440                 445            
 Glu Lys Lys Lys Leu Thr Leu Met Phe Glu Ile Gln Gly Leu Lys Glu
     450                 455                 460                
 Gln Cys Glu Asn Leu Gln Gln Glu Lys Gln Glu Ala Ile Leu Asn Tyr
 465                 470                 475                 480
 Glu Ser Leu Arg Glu Ile Met Glu Ile Leu Gln Thr Glu Leu Gly Glu
                 485                 490                 495    
 Ser Ala Gly Lys Ile Ser Gln Glu Phe Glu Ser Met Lys Gln Gln Gln
             500                 505                 510        
 Ala Ser Asp Val His Glu Leu Gln Gln Lys Leu Arg Thr Ala Phe Thr
         515                 520                 525            
 Glu Lys Asp Ala Leu Leu Glu Thr Val Asn Arg Leu Gln Gly Glu Asn
     530                 535                 540                
 Glu Lys Leu Leu Ser Gln Gln Glu Leu Val Pro Glu Leu Glu Asn Thr
 545                 550                 555                 560
 Ile Lys Asn Leu Gln Glu Lys Asn Gly Val Tyr Leu Leu Ser Leu Ser
                 565                 570                 575    
 Gln Arg Asp Thr Met Leu Lys Glu Leu Glu Gly Lys Ile Asn Ser Leu
             580                 585                 590        
 Thr Glu Glu Lys Asp Asp Phe Ile Asn Lys Leu Lys Asn Ser His Glu
         595                 600                 605            
 Glu Met Asp Asn Phe His Lys Lys Cys Glu Arg Glu Glu Arg Leu Ile
     610                 615                 620                
 Leu Glu Leu Gly Lys Lys Val Glu Gln Thr Ile Gln Tyr Asn Ser Glu
 625                 630                 635                 640
 Leu Glu Gln Lys Val Asn Glu Leu Thr Gly Gly Leu Glu Glu Thr Leu
                 645                 650                 655    
 Lys Glu Lys Asp Gln Asn Asp Gln Lys Leu Glu Lys Leu Met Val Gln
             660                 665                 670        
 Met Lys Val Leu Ser Glu Asp Lys Glu Val Leu Ser Ala Glu Val Lys
         675                 680                 685            
 Ser Leu Tyr Glu Glu Asn Asn Lys Leu Ser Ser Glu Lys Lys Gln Leu
     690                 695                 700                
 Ser Arg Asp Leu Glu Val Phe Leu Ser Gln Lys Glu Asp Val Ile Leu
 705                 710                 715                 720
 Lys Glu His Ile Thr Gln Leu Glu Lys Lys Leu Gln Leu Met Val Glu
                 725                 730                 735    
 Glu Gln Asp Asn Leu Asn Lys Leu Leu Glu Asn Glu Gln Val Gln Lys
             740                 745                 750        
 Leu Phe Val Lys Thr Gln Leu Tyr Gly Phe Leu Lys Glu Met Gly Ser
         755                 760                 765            
 Glu Val Ser Glu Asp Ser Glu Glu Lys Asp Val Val Asn Val Leu Gln
     770                 775                 780                
 Ala Val Gly Glu Ser Leu Ala Lys Ile Asn Glu Glu Lys Cys Asn Leu
 785                 790                 795                 800
 Ala Phe Gln Arg Asp Glu Lys Val Leu Glu Leu Glu Lys Glu Ile Lys
                 805                 810                 815    
 Cys Leu Gln Glu Glu Ser Val Val Gln Cys Glu Glu Leu Lys Ser Leu
             820                 825                 830        
 Leu Arg Asp Tyr Glu Gln Glu Lys Val Leu Leu Arg Lys Glu Leu Glu
         835                 840                 845            
 Glu Ile Gln Ser Glu Lys Glu Ala Leu Gln Ser Asp Leu Leu Glu Met
     850                 855                 860                
 Lys Asn Ala Asn Glu Lys Thr Arg Leu Glu Asn Gln Asn Leu Leu Ile
 865                 870                 875                 880
 Gln Val Glu Glu Val Ser Gln Thr Cys Ser Lys Ser Glu Ile His Asn
                 885                 890                 895    
 Glu Lys Glu Lys Cys Phe Ile Lys Glu His Glu Asn Leu Lys Pro Leu
             900                 905                 910        
 Leu Glu Gln Lys Glu Leu Arg Asp Arg Arg Ala Glu Leu Ile Leu Leu
         915                 920                 925            
 Lys Asp Ser Leu Ala Lys Ser Pro Ser Val Lys Asn Asp Pro Leu Ser
     930                 935                 940                
 Ser Val Lys Glu Leu Glu Glu Lys Ile Glu Asn Leu Glu Lys Glu Cys
 945                 950                 955                 960
 Lys Glu Lys Glu Glu Lys Ile Asn Lys Ile Lys Leu Val Ala Val Lys
                 965                 970                 975    
 Ala Lys Lys Glu Leu Asp Ser Ser Arg Lys Glu Thr Gln Thr Val Lys
             980                 985                 990        
 Glu Glu Leu Glu Ser Leu Arg Ser Glu Lys Asp Gln Leu Ser Ala Ser
         995                1000                1005            
 Met Arg Asp Leu Ile Gln Gly Ala Glu Ser Tyr Lys Asn Leu Leu Leu
    1010                1015                1020                
 Glu Tyr Glu Lys Gln Ser Glu Gln Leu Asp Val Glu Lys Glu Arg Ala
1025                1030                1035                1040
 Asn Asn Phe Glu His Arg Ile Glu Asp Leu Thr Arg Gln Leu Arg Asn
                1045                1050                1055    
 Ser Thr Leu Gln Cys Glu Thr Ile Asn Ser Asp Asn Glu Asp Leu Leu
            1060                1065                1070        
 Ala Arg Ile Glu Thr Leu Gln Ser Asn Ala Lys Leu Leu Glu Val Gln
        1075                1080                1085            
 Ile Leu Glu Val Gln Arg Ala Lys Ala Met Val Asp Lys Glu Leu Glu
    1090                1095                1100                
 Ala Glu Lys Leu Gln Lys Glu Gln Lys Ile Lys Glu His Ala Thr Thr
1105                1110                1115                1120
 Val Asn Glu Leu Glu Glu Leu Gln Val Gln Leu Gln Lys Glu Lys Lys
                1125                1130                1135    
 Gln Leu Gln Lys Thr Met Gln Glu Leu Glu Leu Val Lys Lys Asp Ala
            1140                1145                1150        
 Gln Gln Thr Thr Leu Met Asn Met Glu Ile Ala Asp Tyr Glu Arg Leu
        1155                1160                1165            
 Met Lys Glu Leu Asn Gln Lys Leu Thr Asn Lys Asn Asn Lys Ile Glu
    1170                1175                1180                
 Asp Leu Glu Gln Glu Ile Lys Ile Gln Lys Gln Lys Gln Glu Thr Leu
1185                1190                1195                1200
 Gln Glu Glu Ile Thr Ser Leu Gln Ser Ser Val Gln Gln Tyr Glu Glu
                1205                1210                1215    
 Lys Asn Thr Lys Ile Lys Gln Leu Leu Val Lys Thr Lys Lys Glu Leu
            1220                1225                1230        
 Ala Asp Ser Lys Gln Ala Glu Thr Asp His Leu Ile Leu Gln Ala Ser
        1235                1240                1245            
 Leu Lys Gly Glu Leu Glu Ala Ser Gln Gln Gln Val Glu Val Tyr Lys
    1250                1255                1260                
 Ile Gln Leu Ala Glu Ile Thr Ser Glu Lys His Lys Ile His Glu His
1265                1270                1275                1280
 Leu Lys Thr Ser Ala Glu Gln His Gln Arg Thr Leu Ser Ala Tyr Gln
                1285                1290                1295    
 Gln Arg Val Thr Ala Leu Gln Glu Glu Cys Arg Ala Ala Lys Ala Glu
            1300                1305                1310        
 Gln Ala Thr Val Thr Ser Glu Phe Glu Ser Tyr Lys Val Arg Val His
        1315                1320                1325            
 Asn Val Leu Lys Lys Lys Lys Asn Lys Ser Met Ser Gln Ala Glu Thr
    1330                1335                1340                
 Glu Gly Ala Lys Gln Glu Arg Glu His Leu Glu Met Leu Ile Asp Gln
1345                1350                1355                1360
 Leu Lys Ile Lys Leu Gln Asp Ser Gln Asn Asn Leu Gln Ile Asn Val
                1365                1370                1375    
 Ser Glu Leu Gln Thr Leu Gln Ser Glu His Asp Thr Leu Leu Glu Arg
            1380                1385                1390        
 His Asn Lys Met Leu Gln Glu Thr Val Ser Lys Glu Ala Glu Leu Arg
        1395                1400                1405            
 Glu Lys Leu Cys Ser Ile Gln Ser Glu Asn Met Met Met Lys Ser Glu
    1410                1415                1420                
 His Thr Gln Thr Val Ser Gln Leu Thr Ser Gln Asn Glu Val Leu Arg
1425                1430                1435                1440
 Asn Ser Phe Arg Asp Gln Val Arg His Leu Gln Glu Glu His Arg Lys
                1445                1450                1455    
 Thr Val Glu Thr Leu Gln Gln Gln Leu Ser Lys Met Glu Ala Gln Leu
            1460                1465                1470        
 Phe Gln Leu Lys Asn Glu Pro Thr Thr Arg Ser Pro Val Ser Ser Gln
        1475                1480                1485            
 Gln Ser Leu Lys Asn Leu Arg Glu Arg Arg Asn Thr Asp Leu Pro Leu
    1490                1495                1500                
 Leu Asp Met His Thr Val Thr Arg Glu Glu Gly Glu Gly Met Glu Thr
1505                1510                1515                1520
 Thr Asp Thr Glu Ser Val Ser Ser Ala Ser Thr Tyr Thr Gln Ser Leu
                1525                1530                1535    
 Glu Gln Leu Leu Asn Ser Pro Glu Thr Lys Leu Glu Pro Pro Leu Trp
            1540                1545                1550        
 His Ala Glu Phe Thr Lys Glu Glu Leu Val Gln Lys Leu Ser Ser Thr
        1555                1560                1565            
 Thr Lys Ser Ala Asp His Leu Asn Gly Leu Leu Arg Glu Thr Glu Ala
    1570                1575                1580                
 Thr Asn Ala Ile Leu Met Glu Gln Ile Lys Leu Leu Lys Ser Glu Ile
1585                1590                1595                1600
 Arg Arg Leu Glu Arg Asn Gln Glu Arg Glu Lys Ser Ala Ala Asn Leu
                1605                1610                1615    
 Glu Tyr Leu Lys Asn Val Leu Leu Gln Phe Ile Phe Leu Lys Pro Gly
            1620                1625                1630        
 Ser Glu Arg Glu Arg Leu Leu Pro Val Ile Asn Thr Met Leu Gln Leu
        1635                1640                1645            
 Ser Pro Glu Glu Lys Gly Lys Leu Ala Ala Val Ala Gln Gly Glu Glu
    1650                1655                1660                
 Glu Asn Ala Ser Arg Ser Ser Gly Trp Ala Ser Tyr Leu His Ser Trp
1665                1670                1675                1680
 Ser Gly Leu Arg
                



      <210> 886
      <211> 452
      <212> PRT
      <213> Homo sapiens


      <400> 886
 Met Ala Gly Ala Ile Thr Arg Asn Gln Trp Lys Arg Lys Lys Arg Lys
   1               5                  10                  15    
 Gln Met Asn Gln Tyr Ser Tyr Ile Asp Phe Lys Phe Glu Gln Gly Asp
              20                  25                  30        
 Ile Lys Ile Glu Lys Arg Met Phe Phe Leu Glu Asn Lys Arg Arg His
          35                  40                  45            
 Cys Arg Ser Tyr Asp Arg Arg Ala Leu Leu Pro Ala Val Gln Gln Glu
      50                  55                  60                
 Gln Glu Phe Tyr Glu Gln Lys Ile Lys Glu Met Ala Glu His Glu Asp
  65                  70                  75                  80
 Phe Leu Leu Ala Leu Gln Met Asn Glu Glu Gln Tyr Gln Lys Asp Gly
                  85                  90                  95    
 Gln Leu Ile Glu Cys Arg Cys Cys Tyr Gly Glu Phe Pro Phe Glu Glu
             100                 105                 110        
 Leu Thr Gln Cys Ala Asp Ala His Leu Phe Cys Lys Glu Cys Leu Ile
         115                 120                 125            
 Arg Tyr Ala Gln Glu Ala Val Phe Gly Ser Gly Lys Leu Glu Leu Ser
     130                 135                 140                
 Cys Met Glu Gly Ser Cys Thr Cys Ser Phe Pro Thr Ser Glu Leu Glu
 145                 150                 155                 160
 Lys Val Leu Pro Gln Thr Ile Leu Tyr Lys Tyr Tyr Glu Arg Lys Ala
                 165                 170                 175    
 Glu Glu Glu Val Ala Ala Ala Tyr Ala Asp Glu Leu Val Arg Cys Pro
             180                 185                 190        
 Ser Cys Ser Phe Pro Ala Leu Leu Asp Ser Asp Val Lys Arg Phe Ser
         195                 200                 205            
 Cys Pro Asn Pro His Cys Arg Lys Glu Thr Cys Arg Lys Cys Gln Gly
     210                 215                 220                
 Leu Trp Lys Glu His Asn Gly Leu Thr Cys Glu Glu Leu Ala Glu Lys
 225                 230                 235                 240
 Asp Asp Ile Lys Tyr Arg Thr Ser Ile Glu Glu Lys Met Thr Ala Ala
                 245                 250                 255    
 Arg Ile Arg Lys Cys His Lys Cys Gly Thr Gly Leu Ile Lys Ser Glu
             260                 265                 270        
 Gly Cys Asn Arg Met Ser Cys Arg Cys Gly Ala Gln Met Cys Tyr Leu
         275                 280                 285            
 Cys Arg Val Ser Ile Asn Gly Tyr Asp His Phe Cys Gln His Pro Arg
     290                 295                 300                
 Ser Pro Gly Ala Pro Cys Gln Glu Cys Ser Arg Cys Ser Leu Trp Thr
 305                 310                 315                 320
 Asp Pro Thr Glu Asp Asp Glu Lys Leu Ile Glu Glu Ile Gln Lys Glu
                 325                 330                 335    
 Ala Glu Glu Glu Gln Lys Arg Lys Asn Gly Glu Asn Thr Phe Lys Arg
             340                 345                 350        
 Ile Gly Pro Pro Leu Glu Lys Pro Val Glu Lys Val Gln Arg Val Glu
         355                 360                 365            
 Ala Leu Pro Arg Pro Val Pro Gln Asn Leu Pro Gln Pro Gln Met Pro
     370                 375                 380                
 Pro Tyr Ala Phe Ala His Pro Pro Phe Pro Leu Pro Pro Val Arg Pro
 385                 390                 395                 400
 Val Phe Asn Asn Phe Pro Leu Asn Met Gly Pro Ile Pro Ala Pro Tyr
                 405                 410                 415    
 Val Pro Pro Leu Pro Asn Val Arg Val Asn Tyr Asp Phe Gly Pro Ile
             420                 425                 430        
 His Met Pro Leu Glu His Asn Leu Pro Met His Phe Gly Pro Gln Pro
         435                 440                 445            
 Arg His Arg Phe
     450        



      <210> 887
      <211> 200
      <212> PRT
      <213> Homo sapiens


      <400> 887
 Met Ser Ser Arg Gly Gly Lys Lys Lys Ser Thr Lys Thr Ser Arg Ser
   1               5                  10                  15    
 Ala Lys Ala Gly Val Ile Phe Pro Val Gly Arg Met Leu Arg Tyr Ile
              20                  25                  30        
 Lys Lys Gly His Pro Lys Tyr Arg Ile Gly Val Gly Ala Pro Val Tyr
          35                  40                  45            
 Met Ala Ala Val Leu Glu Tyr Leu Thr Gly Asn Thr Leu Glu Lys Lys
      50                  55                  60                
 Gly Gly Lys Glu Phe Val Glu Ala Val Leu Glu Leu Arg Lys Lys Asn
  65                  70                  75                  80
 Gly Pro Leu Glu Val Ala Gly Ala Ala Val Ser Ala Gly His Gly Leu
                  85                  90                  95    
 Pro Ala Lys Phe Val Ile His Cys Asn Ser Pro Val Trp Gly Ala Asp
             100                 105                 110        
 Lys Cys Glu Glu Leu Leu Glu Lys Thr Val Lys Asn Cys Leu Ala Leu
         115                 120                 125            
 Ala Asp Asp Lys Lys Leu Lys Ser Ile Ala Phe Pro Ser Ile Gly Ser
     130                 135                 140                
 Gly Arg Asn Gly Phe Pro Lys Gln Thr Ala Ala Gln Leu Ile Leu Lys
 145                 150                 155                 160
 Ala Ile Ser Ser Tyr Phe Val Ser Thr Met Ser Ser Ser Ile Lys Thr
                 165                 170                 175    
 Val Tyr Phe Val Leu Phe Asp Ser Glu Ser Ile Gly Ile Tyr Val Gln
             180                 185                 190        
 Glu Met Ala Lys Leu Asp Ala Asn
         195                 200



      <210> 888
      <211> 618
      <212> PRT
      <213> Homo sapiens


      <400> 888
 Met Lys Ser Gly Phe Lys Val Cys Ala Cys Asn Thr Val Arg Asp Ile
   1               5                  10                  15    
 Leu Glu Gly Arg Thr Ile Ser Val Gln Phe Asn Gln Leu Phe Leu Arg
              20                  25                  30        
 Pro Asn Lys Glu Lys Ile Asp Phe Leu Leu Glu Val Cys Ser Arg Ser
          35                  40                  45            
 Val Asn Leu Glu Lys Ala Ser Glu Ser Leu Lys Gly Asn Met Ala Ala
      50                  55                  60                
 Phe Leu Lys Asn Val Cys Leu Gly Leu Glu Asp Leu Gln Tyr Val Phe
  65                  70                  75                  80
 Met Ile Ser Ser His Glu Leu Phe Ile Thr Leu Leu Lys Asp Glu Glu
                  85                  90                  95    
 Arg Lys Leu Leu Val Asp Gln Met Arg Lys Arg Ser Pro Arg Val Asn
             100                 105                 110        
 Leu Cys Ile Lys Pro Val Thr Ser Phe Tyr Asp Ile Pro Ala Ser Ala
         115                 120                 125            
 Ser Val Asn Ile Gly Gln Leu Glu His Gln Leu Ile Leu Ser Val Asp
     130                 135                 140                
 Pro Trp Arg Ile Arg Gln Ile Leu Ile Glu Leu His Gly Met Thr Ser
 145                 150                 155                 160
 Glu Arg Gln Phe Trp Thr Val Ser Asn Lys Trp Glu Val Pro Ser Val
                 165                 170                 175    
 Tyr Ser Gly Val Ile Leu Gly Ile Lys Asp Asn Leu Thr Arg Asp Leu
             180                 185                 190        
 Val Tyr Ile Leu Met Ala Lys Gly Leu His Cys Ser Thr Val Lys Asp
         195                 200                 205            
 Phe Ser His Ala Lys Gln Leu Phe Ala Ala Cys Leu Glu Leu Val Thr
     210                 215                 220                
 Glu Phe Ser Pro Lys Leu Arg Gln Val Met Leu Asn Glu Met Leu Leu
 225                 230                 235                 240
 Leu Asp Ile His Thr His Glu Ala Gly Thr Gly Gln Ala Gly Glu Arg
                 245                 250                 255    
 Pro Pro Ser Asp Leu Ile Ser Arg Val Arg Gly Tyr Leu Glu Met Arg
             260                 265                 270        
 Leu Pro Asp Ile Pro Leu Arg Gln Val Ile Ala Glu Glu Cys Val Ala
         275                 280                 285            
 Phe Met Leu Asn Trp Arg Glu Asn Glu Tyr Leu Thr Leu Gln Val Pro
     290                 295                 300                
 Ala Phe Leu Leu Gln Ser Asn Pro Tyr Val Lys Leu Gly Gln Leu Leu
 305                 310                 315                 320
 Ala Ala Thr Cys Lys Glu Leu Pro Gly Pro Lys Glu Ser Arg Arg Thr
                 325                 330                 335    
 Ala Lys Asp Leu Trp Glu Val Val Val Gln Ile Cys Ser Val Ser Ser
             340                 345                 350        
 Gln His Lys Arg Gly Asn Asp Gly Arg Val Ser Leu Ile Lys Gln Arg
         355                 360                 365            
 Glu Ser Thr Leu Gly Ile Met Tyr Arg Ser Glu Leu Leu Ser Phe Ile
     370                 375                 380                
 Lys Lys Leu Arg Glu Pro Leu Val Leu Thr Ile Ile Leu Ser Leu Phe
 385                 390                 395                 400
 Val Lys Leu His Asn Val Arg Glu Asp Ile Val Asn Asp Ile Thr Ala
                 405                 410                 415    
 Glu His Ile Ser Ile Trp Pro Ser Ser Ile Pro Asn Leu Gln Ser Val
             420                 425                 430        
 Asp Phe Glu Ala Val Ala Ile Thr Val Lys Glu Leu Val Arg Tyr Thr
         435                 440                 445            
 Leu Ser Ile Asn Pro Asn Asn His Ser Trp Leu Ile Ile Gln Ala Asp
     450                 455                 460                
 Ile Tyr Phe Ala Thr Asn Gln Tyr Ser Ala Ala Leu His Tyr Tyr Leu
 465                 470                 475                 480
 Gln Ala Gly Ala Val Cys Ser Asp Phe Phe Asn Lys Ala Val Pro Pro
                 485                 490                 495    
 Asp Val Tyr Thr Asp Gln Val Ile Lys Arg Met Ile Lys Cys Cys Ser
             500                 505                 510        
 Leu Leu Asn Cys His Thr Gln Val Ala Ile Leu Cys Gln Phe Leu Arg
         515                 520                 525            
 Glu Ile Asp Tyr Lys Thr Ala Phe Lys Ser Leu Gln Glu Gln Asn Ser
     530                 535                 540                
 His Asp Ala Met Asp Ser Tyr Tyr Asp Tyr Ile Trp Asp Val Thr Ile
 545                 550                 555                 560
 Leu Glu Tyr Leu Thr Tyr Leu His His Lys Arg Gly Glu Thr Asp Lys
                 565                 570                 575    
 Arg Gln Ile Ala Ile Lys Ala Ile Gly Gln Thr Glu Leu Asn Ala Ser
             580                 585                 590        
 Asn Pro Glu Glu Val Leu Gln Leu Ala Ala Gln Arg Arg Lys Lys Lys
         595                 600                 605            
 Phe Leu Gln Ala Met Ala Lys Leu Tyr Phe
     610                 615            



      <210> 889
      <211> 1200
      <212> PRT
      <213> Homo sapiens


      <400> 889
 Met Arg His Pro Phe Pro Val Pro Pro Cys Phe Pro Pro Met Pro Pro
   1               5                  10                  15    
 Pro Met Pro Cys Pro Asn Asn Pro Pro Val Pro Gly Ala Pro Pro Gly
              20                  25                  30        
 Gln Gly Thr Phe Pro Phe Met Met Pro Pro Pro Ser Met Pro His Pro
          35                  40                  45            
 Pro Pro Pro Pro Val Met Pro Gln Gln Val Lys Tyr Gln Tyr Pro Pro
      50                  55                  60                
 Gly Tyr Ser His His Asn Phe Pro Pro Pro Ser Phe Asn Ser Phe Gln
  65                  70                  75                  80
 Asn Asn Pro Ser Ser Phe Leu Pro Ser Ala Asn Asn Ser Ser Ser Pro
                  85                  90                  95    
 His Phe Arg His Leu Pro Pro Tyr Pro Leu Pro Lys Ala Pro Ser Glu
             100                 105                 110        
 Arg Arg Ser Pro Glu Arg Leu Lys His Tyr Asp Asp His Arg His Arg
         115                 120                 125            
 Asp His Ser His Gly Arg Gly Glu Arg His Arg Ser Leu Asp Arg Arg
     130                 135                 140                
 Glu Arg Gly Arg Ser Pro Asp Arg Arg Arg Gln Asp Ser Arg Tyr Arg
 145                 150                 155                 160
 Ser Asp Tyr Asp Arg Gly Arg Thr Pro Ser Arg His Arg Ser Tyr Glu
                 165                 170                 175    
 Arg Ser Ser Arg Ser Pro Ser Arg Glu Lys Lys Arg Ala Arg Trp Glu
             180                 185                 190        
 Glu Glu Lys Asp Arg Trp Ser Asp Asn Gln Ser Ser Gly Lys Asp Lys
         195                 200                 205            
 Asn Tyr Thr Ser Ile Lys Glu Lys Glu Pro Glu Glu Thr Met Pro Asp
     210                 215                 220                
 Lys Asn Glu Glu Glu Glu Glu Glu Leu Leu Lys Pro Val Trp Val Arg
 225                 230                 235                 240
 Cys Thr His Ser Glu Asn Tyr Tyr Ser Ser Asp Pro Met Asp Gln Val
                 245                 250                 255    
 Gly Asp Ser Thr Val Val Gly Thr Ser Arg Leu Arg Asp Leu Tyr Asp
             260                 265                 270        
 Lys Phe Glu Glu Glu Leu Gly Ser Arg Gln Glu Lys Ala Lys Ala Ala
         275                 280                 285            
 Arg Pro Pro Trp Glu Pro Pro Lys Thr Lys Leu Asp Glu Asp Leu Glu
     290                 295                 300                
 Ser Ser Ser Glu Ser Glu Cys Glu Ser Asp Glu Asp Ser Thr Cys Ser
 305                 310                 315                 320
 Ser Ser Ser Asp Ser Glu Val Phe Asp Val Ile Ala Glu Ile Lys Arg
                 325                 330                 335    
 Lys Lys Ala His Pro Asp Arg Leu His Asp Glu Leu Trp Tyr Asn Asp
             340                 345                 350        
 Pro Gly Gln Met Asn Asp Gly Pro Leu Cys Lys Cys Ser Ala Lys Ala
         355                 360                 365            
 Arg Arg Thr Gly Ile Arg His Ser Ile Tyr Pro Gly Glu Glu Ala Ile
     370                 375                 380                
 Lys Pro Cys Arg Pro Met Thr Asn Asn Ala Gly Arg Leu Phe His Tyr
 385                 390                 395                 400
 Arg Ile Thr Val Ser Pro Pro Thr Asn Phe Leu Thr Asp Arg Pro Thr
                 405                 410                 415    
 Val Ile Glu Tyr Asp Asp His Glu Tyr Ile Phe Glu Gly Phe Ser Met
             420                 425                 430        
 Phe Ala His Ala Pro Leu Thr Asn Ile Pro Leu Cys Lys Val Ile Arg
         435                 440                 445            
 Phe Asn Ile Asp Tyr Thr Ile His Phe Ile Glu Glu Met Met Pro Glu
     450                 455                 460                
 Asn Phe Cys Val Lys Gly Leu Glu Leu Phe Ser Leu Phe Leu Phe Arg
 465                 470                 475                 480
 Asp Ile Leu Glu Leu Tyr Asp Trp Asn Leu Lys Gly Pro Leu Phe Glu
                 485                 490                 495    
 Asp Ser Pro Pro Cys Cys Pro Arg Phe His Phe Met Pro Arg Phe Val
             500                 505                 510        
 Arg Phe Leu Pro Asp Gly Gly Lys Glu Val Leu Ser Met His Gln Ile
         515                 520                 525            
 Leu Leu Tyr Leu Leu Arg Cys Ser Lys Ala Leu Val Pro Glu Glu Glu
     530                 535                 540                
 Ile Ala Asn Met Leu Gln Trp Glu Glu Leu Glu Trp Gln Lys Tyr Ala
 545                 550                 555                 560
 Glu Glu Cys Lys Gly Met Ile Val Thr Asn Pro Gly Thr Lys Pro Ser
                 565                 570                 575    
 Ser Val Arg Ile Asp Gln Leu Asp Arg Glu Gln Phe Asn Pro Asp Val
             580                 585                 590        
 Ile Thr Phe Pro Ile Ile Val His Phe Gly Ile Arg Pro Ala Gln Leu
         595                 600                 605            
 Ser Tyr Ala Gly Asp Pro Gln Tyr Gln Lys Leu Trp Lys Ser Tyr Val
     610                 615                 620                
 Lys Leu Arg His Leu Leu Ala Asn Ser Pro Lys Val Lys Gln Thr Asp
 625                 630                 635                 640
 Lys Gln Lys Leu Ala Gln Arg Glu Glu Ala Leu Gln Lys Ile Arg Gln
                 645                 650                 655    
 Lys Asn Thr Met Arg Arg Glu Val Thr Val Glu Leu Ser Ser Gln Gly
             660                 665                 670        
 Phe Trp Lys Thr Gly Ile Arg Ser Asp Val Cys Gln His Ala Met Met
         675                 680                 685            
 Leu Pro Val Leu Thr His His Ile Arg Tyr His Gln Cys Leu Met His
     690                 695                 700                
 Leu Asp Lys Leu Ile Gly Tyr Thr Phe Gln Asp Arg Cys Leu Leu Gln
 705                 710                 715                 720
 Leu Ala Met Thr His Pro Ser His His Leu Asn Phe Gly Met Asn Pro
                 725                 730                 735    
 Asp His Ala Arg Asn Ser Leu Ser Asn Cys Gly Ile Arg Gln Pro Lys
             740                 745                 750        
 Tyr Gly Asp Arg Lys Val His His Met His Met Arg Lys Lys Gly Ile
         755                 760                 765            
 Asn Thr Leu Ile Asn Ile Met Ser Arg Leu Gly Gln Asp Asp Pro Thr
     770                 775                 780                
 Pro Ser Arg Ile Asn His Asn Glu Arg Leu Glu Phe Leu Gly Asp Ala
 785                 790                 795                 800
 Val Val Glu Phe Leu Thr Ser Val His Leu Tyr Tyr Leu Phe Pro Ser
                 805                 810                 815    
 Leu Glu Glu Gly Gly Leu Ala Thr Tyr Arg Thr Ala Ile Val Gln Asn
             820                 825                 830        
 Gln His Leu Ala Met Leu Ala Lys Lys Leu Glu Leu Asp Arg Phe Met
         835                 840                 845            
 Leu Tyr Ala His Gly Pro Asp Leu Cys Arg Glu Ser Asp Leu Arg His
     850                 855                 860                
 Ala Met Ala Asn Cys Phe Glu Ala Leu Ile Gly Ala Val Tyr Leu Glu
 865                 870                 875                 880
 Gly Ser Leu Glu Glu Ala Lys Gln Leu Phe Gly Arg Leu Leu Phe Asn
                 885                 890                 895    
 Asp Pro Asp Leu Arg Glu Val Trp Leu Asn Tyr Pro Leu His Pro Leu
             900                 905                 910        
 Gln Leu Gln Glu Pro Asn Thr Asp Arg Gln Leu Ile Glu Thr Ser Pro
         915                 920                 925            
 Val Leu Gln Lys Leu Thr Glu Phe Glu Glu Ala Ile Gly Val Ile Phe
     930                 935                 940                
 Thr His Val Arg Leu Leu Ala Arg Ala Phe Thr Leu Arg Thr Val Gly
 945                 950                 955                 960
 Phe Asn His Leu Thr Leu Gly His Asn Gln Arg Met Glu Phe Leu Gly
                 965                 970                 975    
 Asp Ser Ile Met Gln Leu Val Ala Thr Glu Tyr Leu Phe Ile His Phe
             980                 985                 990        
 Pro Asp His His Glu Gly His Leu Thr Leu Leu Arg Ser Ser Leu Val
         995                1000                1005            
 Asn Asn Arg Thr Gln Ala Lys Val Ala Glu Glu Leu Gly Met Gln Glu
    1010                1015                1020                
 Tyr Ala Ile Thr Asn Asp Lys Thr Lys Arg Pro Val Ala Leu Arg Thr
1025                1030                1035                1040
 Lys Thr Leu Ala Asp Leu Leu Glu Ser Phe Ile Ala Ala Leu Tyr Ile
                1045                1050                1055    
 Asp Lys Asp Leu Glu Tyr Val His Thr Phe Met Asn Val Cys Phe Phe
            1060                1065                1070        
 Pro Arg Leu Lys Glu Phe Ile Leu Asn Gln Asp Trp Asn Asp Pro Lys
        1075                1080                1085            
 Ser Gln Leu Gln Gln Cys Cys Leu Thr Leu Arg Thr Glu Gly Lys Glu
    1090                1095                1100                
 Pro Asp Ile Pro Leu Tyr Lys Thr Leu Gln Thr Val Gly Pro Ser His
1105                1110                1115                1120
 Ala Arg Thr Tyr Thr Val Ala Val Tyr Phe Lys Gly Glu Arg Ile Gly
                1125                1130                1135    
 Cys Gly Lys Gly Pro Ser Ile Gln Gln Ala Glu Met Gly Ala Ala Met
            1140                1145                1150        
 Asp Ala Leu Glu Lys Tyr Asn Phe Pro Gln Met Ala His Gln Lys Arg
        1155                1160                1165            
 Phe Ile Glu Arg Lys Tyr Arg Gln Glu Leu Lys Glu Met Arg Trp Glu
    1170                1175                1180                
 Arg Glu His Gln Glu Arg Glu Pro Asp Glu Thr Glu Asp Ile Lys Lys
1185                1190                1195                1200





      <210> 890
      <211> 176
      <212> PRT
      <213> Homo sapiens


      <400> 890
 Met Glu Gly Gly Pro Ala Thr Thr Met Asn Ser Lys Gly Gln Tyr Pro
   1               5                  10                  15    
 Thr Gln Pro Thr Tyr Pro Val Gln Pro Pro Gly Asn Pro Val Tyr Pro
              20                  25                  30        
 Gln Thr Leu His Leu Pro Gln Ala Pro Pro Tyr Thr Asp Ala Pro Pro
          35                  40                  45            
 Ala Tyr Ser Glu Leu Tyr Arg Pro Ser Phe Val His Pro Gly Ala Ala
      50                  55                  60                
 Thr Val Pro Thr Met Ser Ala Ala Phe Pro Gly Ala Ser Leu Tyr Leu
  65                  70                  75                  80
 Pro Met Ala Gln Ser Val Ala Val Gly Pro Leu Gly Ser Thr Ile Pro
                  85                  90                  95    
 Met Ala Tyr Tyr Pro Val Gly Pro Ile Tyr Pro Pro Gly Ser Thr Val
             100                 105                 110        
 Leu Val Glu Gly Gly Tyr Asp Ala Gly Ala Arg Phe Gly Ala Gly Ala
         115                 120                 125            
 Thr Ala Gly Asn Ile Pro Pro Pro Pro Pro Gly Cys Pro Pro Asn Ala
     130                 135                 140                
 Ala Gln Leu Ala Val Met Gln Gly Ala Asn Val Leu Val Thr Gln Arg
 145                 150                 155                 160
 Lys Gly Asn Phe Phe Met Gly Gly Ser Asp Gly Gly Tyr Thr Ile Trp
                 165                 170                 175    





      <210> 891
      <211> 87
      <212> PRT
      <213> Homo sapiens


      <400> 891
 Met Glu Gly Gly Pro Ala Thr Thr Met Asn Ser Lys Gly Gln Tyr Pro
   1               5                  10                  15    
 Thr Gln Pro Thr Tyr Pro Val Gln Pro Pro Gly Asn Pro Val Tyr Pro
              20                  25                  30        
 Gln Thr Leu His Leu Pro Gln Ala Pro Pro Tyr Thr Asp Ala Pro Pro
          35                  40                  45            
 Pro Gly Cys Pro Pro Asn Ala Ala Gln Leu Ala Val Met Gln Gly Ala
      50                  55                  60                
 Asn Val Leu Val Thr Gln Arg Lys Gly Asn Phe Phe Met Gly Gly Ser
  65                  70                  75                  80
 Asp Gly Gly Tyr Thr Ile Trp
                  85        



      <210> 892
      <211> 271
      <212> PRT
      <213> Homo sapiens


      <400> 892
 Met Ala Cys Ala Arg Leu Leu Ile Ser Val Tyr Ser Glu Ser Gly Glu
   1               5                  10                  15    
 Ser Ser Gly Lys Asn Val Thr Leu Pro Ala Val Phe Lys Ala Pro Ile
              20                  25                  30        
 Arg Pro Asp Ile Val Asn Phe Val His Thr Asn Leu His Lys Asn Asn
          35                  40                  45            
 Arg Gln Pro Tyr Ala Val Ser Glu Leu Ala Gly Arg Gln Thr Ser Ala
      50                  55                  60                
 Glu Ser Trp Gly Thr Gly Arg Ala Val Ala Gln Ile Pro Arg Val Gln
  65                  70                  75                  80
 Ala Leu Ser Ala Leu Val Met Ser Lys Gly His Ser Ile Glu Glu Val
                  85                  90                  95    
 Pro Glu Leu Pro Leu Val Val Glu Asp Lys Val Glu Gly Tyr Lys Lys
             100                 105                 110        
 Thr Lys Glu Ala Val Ser Leu Leu Lys Lys Phe Lys Ala Trp Asn Asp
         115                 120                 125            
 Ile Lys Lys Asp Tyr Ala Ser Gln Arg Met Arg Ala Gly Lys Gly Lys
     130                 135                 140                
 Met Arg Asn Arg His Cys Ile Gln Cys Thr Gly Pro Tyr Ile Ile Tyr
 145                 150                 155                 160
 Asn Glu Asp Asn Gly Ile Ile Lys Ala Phe Arg Asn Ile Pro Gly Ile
                 165                 170                 175    
 Thr Leu Leu Asn Ala Arg Asn His Lys Leu Trp Val Asp Lys Ala Ala
             180                 185                 190        
 Ala Ala Ala Glu Ala Leu Glu Ala Lys Ser Asp Glu Lys Gly Val Ala
         195                 200                 205            
 Gly Lys Lys Pro Val Val Gly Lys Lys Gly Lys Lys Ile Ala Val Gly
     210                 215                 220                
 Val Lys Lys Gln Lys Lys Pro Leu Val Gly Lys Lys Ala Ala Ala Thr
 225                 230                 235                 240
 Lys Lys Pro Val Pro Glu Lys Lys Pro Ala Glu Lys Lys Pro Thr Thr
                 245                 250                 255    
 Glu Glu Arg Ser Leu Leu His Lys Leu Leu Asn Leu Ile Ile Pro
             260                 265                 270    



      <210> 893
      <211> 270
      <212> PRT
      <213> Homo sapiens


      <400> 893
 Met Glu Gly Val Leu Tyr Lys Trp Thr Asn Tyr Leu Thr Gly Trp Gln
   1               5                  10                  15    
 Pro Arg Trp Phe Val Leu Asp Asn Gly Ile Leu Ser Tyr Tyr Asp Ser
              20                  25                  30        
 Gln Asp Asp Val Cys Lys Gly Ser Lys Gly Ser Ile Lys Met Ala Val
          35                  40                  45            
 Cys Glu Ile Lys Ala Asp Asn Thr Arg Met Glu Leu Ile Ile Pro Gly
      50                  55                  60                
 Glu Gln His Phe Tyr Met Lys Ala Val Asn Ala Ala Glu Arg Gln Arg
  65                  70                  75                  80
 Trp Leu Val Ala Leu Gly Ser Ser Lys Ala Cys Leu Thr Asp Thr Arg
                  85                  90                  95    
 Thr Lys Asn Glu Lys Glu Arg Ser Glu Thr Ser Glu Ser Leu Lys Thr
             100                 105                 110        
 Lys Met Ser Glu Leu Arg Leu Tyr Cys Asp Leu Leu Met Gln Gln Val
         115                 120                 125            
 His Thr Ile Gln Glu Phe Val His His Asp Glu Asn His Ser Ser Pro
     130                 135                 140                
 Ser Ala Glu Val Glu Arg Arg Gly Ser Leu His Asn Met Asn Glu Ala
 145                 150                 155                 160
 Ser Ser Leu Leu Ser Ala Thr Cys Asn Thr Phe Ile Thr Thr Leu Glu
                 165                 170                 175    
 Glu Cys Val Lys Ile Ala Asn Ala Lys Phe Lys Pro Glu Met Phe Gln
             180                 185                 190        
 Leu His His Pro Asp Pro Leu Val Ser Pro Val Ser Pro Ser Pro Val
         195                 200                 205            
 Gln Met Arg Thr Gly Val Asn Ile Asp Arg Met Phe Asn Val Phe Ile
     210                 215                 220                
 Asn Val Phe Ile Gly Pro Val His Cys Ser Lys Asn Thr Leu Asn Gly
 225                 230                 235                 240
 Asp Leu Ala Ser Ala Thr Ile Pro Glu Glu Ser Arg Leu Met Ala Lys
                 245                 250                 255    
 Lys Gln Ser Glu Ser Glu Asp Thr Leu Pro Ser Phe Ser Ser
             260                 265                 270



      <210> 894
      <211> 216
      <212> PRT
      <213> Homo sapiens


      <400> 894
 Met Glu Ala Glu Gly Cys Arg Tyr Gln Phe Arg Val Ala Leu Leu Gly
   1               5                  10                  15    
 Asp Ala Ala Val Gly Lys Thr Ser Leu Leu Arg Ser Tyr Val Ala Gly
              20                  25                  30        
 Ala Pro Gly Ala Pro Gln Pro Lys Pro Glu Pro Thr Val Gly Ala Glu
          35                  40                  45            
 Cys Tyr Arg Arg Ala Leu Gln Leu Arg Ala Gly Pro Arg Val Lys Leu
      50                  55                  60                
 Gln Leu Trp Asp Thr Ala Gly His Glu Arg Phe Ser Cys Ile Thr Gly
  65                  70                  75                  80
 Ser Phe Tyr Arg Asn Val Val Gly Val Leu Leu Val Phe Asp Val Thr
                  85                  90                  95    
 Asn Arg Lys Ser Phe Glu His Ile Gln Asp Trp His Gln Glu Val Met
             100                 105                 110        
 Ala Thr Gln Gly Pro Asp Lys Val Ile Phe Leu Leu Val Gly His Lys
         115                 120                 125            
 Ser Asp Leu Gln Ser Thr Arg Cys Val Ser Ala Gln Glu Ala Glu Glu
     130                 135                 140                
 Leu Ala Ala Ser Leu Gly Met Ala Phe Val Glu Thr Ser Val Lys Asn
 145                 150                 155                 160
 Asn Cys Asn Val Asp Leu Ala Phe Asp Thr Leu Ala Asp Ala Ile Gln
                 165                 170                 175    
 Gln Ala Leu Gln Gln Gly Asp Ile Lys Leu Glu Glu Gly Trp Gly Gly
             180                 185                 190        
 Val Arg Leu Ile His Lys Thr Gln Ile Pro Arg Ser Pro Ser Arg Lys
         195                 200                 205            
 Gln His Ser Gly Pro Cys Gln Cys
     210                 215    



      <210> 895
      <211> 961
      <212> PRT
      <213> Homo sapiens


      <400> 895
 Met Asn Leu Gln Asp Ile Arg Tyr Ile Leu Lys Asn Asp Leu Lys Ala
   1               5                  10                  15    
 Ser Pro Glu Asp Phe Thr Gly Ala Gln Arg Thr Gln Pro Thr Glu Ser
              20                  25                  30        
 Pro Arg Val Gln Arg Tyr Gly Leu His Pro Asp Val Asn Val Tyr Leu
          35                  40                  45            
 Gly Leu Thr Ser Glu His Pro Arg Glu Thr Pro Asp Met Glu Ile Ile
      50                  55                  60                
 Glu Leu Lys Glu Met Gly Ser Gln Pro His Ser Pro Arg Val His Ser
  65                  70                  75                  80
 Leu Phe Thr Glu Gly Thr Leu Asp Pro Gln Ala Pro Asp Pro Cys Leu
                  85                  90                  95    
 Met Ala Arg Glu Thr Gln Asn Gln Asp Ala Pro Cys Pro Ala Pro Phe
             100                 105                 110        
 Met Ala Glu Glu Ala Ser Ser Pro Ser Thr Gly Gln Pro Ser Leu Cys
         115                 120                 125            
 Ser Phe Glu Ile Asn Glu Ile Tyr Ser Gly Cys Leu Ile Leu Glu Asp
     130                 135                 140                
 Asp Ile Glu Glu Pro Pro Gly Ala Ala Ser Ser Leu Glu Ala Asp Gly
 145                 150                 155                 160
 Pro Asn Gln Val Asp Glu Leu Lys Ser Met Glu Glu Glu Leu Asp Lys
                 165                 170                 175    
 Met Glu Arg Glu Ala Cys Cys Phe Gly Ser Glu Asp Glu Ser Ser Ser
             180                 185                 190        
 Lys Ala Glu Thr Glu Tyr Ser Phe Asp Asp Trp Asp Trp Gln Asn Gly
         195                 200                 205            
 Ser Leu Ser Ser Leu Ser Leu Pro Glu Ser Thr Arg Glu Ala Lys Ser
     210                 215                 220                
 Asn Leu Asn Asn Met Ser Thr Thr Glu Glu Tyr Leu Ile Ser Lys Cys
 225                 230                 235                 240
 Val Leu Asp Leu Lys Ile Met Gln Thr Ile Met His Glu Asn Asp Asp
                 245                 250                 255    
 Arg Leu Arg Asn Ile Glu Gln Ile Leu Asp Glu Val Glu Met Lys Gln
             260                 265                 270        
 Lys Glu Gln Glu Glu Arg Met Ser Leu Trp Ala Thr Ser Arg Glu Phe
         275                 280                 285            
 Thr Asn Ala Tyr Lys Leu Pro Leu Ala Val Gly Pro Pro Ser Leu Asn
     290                 295                 300                
 Tyr Ile Pro Pro Val Leu Gln Leu Ser Gly Gly Gln Lys Pro Asp Thr
 305                 310                 315                 320
 Ser Gly Asn Tyr Pro Thr Leu Pro Arg Phe Pro Arg Met Leu Pro Thr
                 325                 330                 335    
 Leu Cys Asp Pro Gly Lys Gln Asn Thr Asp Glu Gln Phe Gln Cys Thr
             340                 345                 350        
 Gln Gly Ala Lys Asp Ser Leu Glu Thr Ser Arg Ile Gln Asn Thr Ser
         355                 360                 365            
 Ser Gln Gly Arg Pro Arg Glu Ser Thr Ala Gln Ala Lys Ala Thr Gln
     370                 375                 380                
 Phe Asn Ser Ala Leu Phe Thr Leu Ser Ser His Arg Gln Gly Pro Ser
 385                 390                 395                 400
 Ala Ser Pro Ser Cys His Trp Asp Ser Thr Arg Met Ser Val Glu Pro
                 405                 410                 415    
 Val Ser Ser Glu Ile Tyr Asn Ala Glu Ser Arg Asn Lys Asp Asp Gly
             420                 425                 430        
 Lys Val His Leu Lys Trp Lys Met Glu Val Lys Glu Met Ala Lys Lys
         435                 440                 445            
 Ala Ala Thr Gly Gln Leu Thr Val Pro Pro Trp His Pro Gln Ser Ser
     450                 455                 460                
 Leu Thr Leu Glu Ser Glu Ala Glu Asn Glu Pro Asp Ala Leu Leu Gln
 465                 470                 475                 480
 Pro Pro Ile Arg Ser Pro Glu Asn Thr Asp Trp Gln Arg Val Ile Glu
                 485                 490                 495    
 Tyr His Arg Glu Asn Asp Glu Pro Arg Gly Asn Gly Lys Phe Asp Lys
             500                 505                 510        
 Thr Gly Asn Asn Asp Cys Asp Ser Asp Gln His Gly Arg Gln Pro Arg
         515                 520                 525            
 Leu Gly Ser Phe Thr Ser Ile Arg His Pro Ser Pro Arg Gln Lys Glu
     530                 535                 540                
 Gln Pro Glu His Ser Glu Ala Phe Gln Ala Ser Ser Asp Thr Leu Val
 545                 550                 555                 560
 Ala Val Glu Lys Ser Tyr Ser Thr Ser Ser Pro Ile Glu Glu Asp Phe
                 565                 570                 575    
 Glu Gly Ile Gln Gly Ala Phe Ala Gln Pro Gln Val Ser Gly Glu Glu
             580                 585                 590        
 Lys Phe Gln Met Arg Lys Ile Leu Gly Lys Asn Ala Glu Ile Leu Pro
         595                 600                 605            
 Arg Ser Gln Phe Gln Pro Val Arg Ser Thr Glu Asp Glu Gln Glu Glu
     610                 615                 620                
 Thr Ser Lys Glu Ser Pro Lys Glu Leu Lys Glu Lys Asp Ile Ser Leu
 625                 630                 635                 640
 Thr Asp Ile Gln Asp Leu Ser Ser Ile Ser Tyr Glu Pro Asp Ser Ser
                 645                 650                 655    
 Phe Lys Glu Ala Ser Cys Lys Thr Pro Lys Ile Asn His Ala Pro Thr
             660                 665                 670        
 Ser Val Ser Thr Pro Leu Ser Pro Gly Ser Val Ser Ser Ala Ala Ser
         675                 680                 685            
 Gln Tyr Lys Asp Cys Leu Glu Ser Ile Thr Phe Gln Val Lys Thr Glu
     690                 695                 700                
 Phe Ala Ser Cys Trp Asn Ser Gln Glu Phe Ile Gln Thr Leu Ser Asp
 705                 710                 715                 720
 Asp Phe Ile Ser Val Arg Glu Arg Ala Lys Lys Leu Asp Ser Leu Leu
                 725                 730                 735    
 Thr Ser Ser Glu Thr Pro Pro Ser Arg Leu Thr Gly Leu Lys Arg Leu
             740                 745                 750        
 Ser Ser Phe Ile Gly Ala Gly Ser Pro Ser Leu Val Lys Ala Cys Asp
         755                 760                 765            
 Ser Ser Pro Pro His Ala Thr Gln Arg Arg Ser Leu Pro Lys Val Glu
     770                 775                 780                
 Ala Phe Ser Gln His Arg Ile Asp Glu Leu Pro Pro Pro Ser Gln Glu
 785                 790                 795                 800
 Leu Leu Asp Asp Ile Glu Leu Leu Lys Gln Gln Gln Gly Ser Ser Thr
                 805                 810                 815    
 Val Leu His Glu Asn Thr Ala Ser Asp Gly Gly Gly Thr Ala Asn Asp
             820                 825                 830        
 Gln Arg His Leu Glu Glu Gln Glu Thr Asp Ser Lys Lys Glu Asp Ser
         835                 840                 845            
 Ser Met Leu Leu Ser Lys Glu Thr Glu Asp Leu Gly Glu Asp Thr Glu
     850                 855                 860                
 Arg Ala His Ser Thr Leu Asp Glu Asp Leu Glu Arg Trp Leu Gln Pro
 865                 870                 875                 880
 Pro Glu Glu Ser Val Glu Leu Gln Asp Leu Pro Lys Gly Ser Glu Arg
                 885                 890                 895    
 Glu Thr Asn Ile Lys Asp Gln Lys Val Gly Glu Glu Lys Arg Lys Arg
             900                 905                 910        
 Glu Asp Ser Ile Thr Pro Glu Arg Arg Lys Ser Glu Gly Val Leu Gly
         915                 920                 925            
 Thr Ser Glu Glu Asp Glu Leu Lys Ser Cys Phe Trp Lys Arg Leu Gly
     930                 935                 940                
 Trp Ser Glu Ser Ser Arg Ile Ile Val Leu Asp Gln Ser Asp Leu Ser
 945                 950                 955                 960
 Asp
    



      <210> 896
      <211> 828
      <212> PRT
      <213> Homo sapiens


      <400> 896
 Met Ala Ser Leu Asp Phe Thr Leu Asp Gln Ser Cys Phe Thr Cys Leu
   1               5                  10                  15    
 Pro Ala Gly Gln Pro Arg Met Ser Gly His Cys Glu Pro Ile Ala Phe
              20                  25                  30        
 Leu Leu Phe Val Phe Tyr Leu Cys Ala Asp Leu Val Gln Asn Thr Thr
          35                  40                  45            
 Ser Gly Gln Gly Ile Val Thr Gly Gln Gln Ser Pro Arg Gly Glu Val
      50                  55                  60                
 Ala Gly Ala Met Val Leu Pro Gly Gln Val Lys Gly Asp Val Asn Trp
  65                  70                  75                  80
 His Leu Ala Phe Ser Trp Ser Leu Glu Gly Leu Phe Gly Thr Gln Lys
                  85                  90                  95    
 Met Gly Ser Arg Leu Met Asp Ser Asp Met Asp Tyr Glu Arg Pro Asn
             100                 105                 110        
 Val Glu Thr Ile Lys Cys Val Val Val Gly Asp Asn Ala Val Gly Lys
         115                 120                 125            
 Thr Arg Leu Ile Cys Ala Arg Ala Cys Asn Ala Thr Leu Thr Gln Tyr
     130                 135                 140                
 Gln Leu Leu Ala Thr His Val Pro Thr Val Trp Ala Ile Asp Gln Tyr
 145                 150                 155                 160
 Arg Val Cys Gln Glu Val Leu Glu Arg Ser Arg Asp Val Val Asp Asp
                 165                 170                 175    
 Val Ser Val Ser Leu Arg Leu Trp Asp Thr Phe Gly Asp His His Lys
             180                 185                 190        
 Asp Arg Arg Phe Ala Tyr Gly Arg Ser Asp Val Val Val Leu Cys Phe
         195                 200                 205            
 Ser Ile Ala Asn Pro Asn Ser Leu His His Val Lys Thr Met Trp Tyr
     210                 215                 220                
 Pro Glu Ile Lys His Phe Cys Pro Arg Ala Pro Val Ile Leu Val Gly
 225                 230                 235                 240
 Cys Gln Leu Asp Leu Arg Tyr Ala Asp Leu Glu Ala Val Asn Arg Ala
                 245                 250                 255    
 Arg Arg Pro Leu Ala Arg Pro Ile Lys Pro Asn Glu Ile Leu Pro Pro
             260                 265                 270        
 Glu Lys Gly Arg Glu Val Ala Lys Glu Leu Gly Ile Pro Tyr Tyr Glu
         275                 280                 285            
 Thr Ser Val Val Ala Gln Phe Gly Ile Lys Asp Val Phe Asp Asn Ala
     290                 295                 300                
 Ile Arg Ala Ala Leu Ile Ser Arg Arg His Leu Gln Phe Trp Lys Ser
 305                 310                 315                 320
 His Leu Arg Asn Val Gln Arg Pro Leu Leu Gln Ala Pro Phe Leu Pro
                 325                 330                 335    
 Pro Lys Pro Pro Pro Pro Ile Ile Val Val Pro Asp Pro Pro Ser Ser
             340                 345                 350        
 Ser Glu Glu Cys Pro Ala His Leu Leu Glu Asp Pro Leu Cys Ala Asp
         355                 360                 365            
 Val Ile Leu Val Leu Gln Glu Arg Val Arg Ile Phe Ala His Lys Ile
     370                 375                 380                
 Tyr Leu Ser Thr Ser Ser Ser Lys Phe Tyr Asp Leu Phe Leu Met Asp
 385                 390                 395                 400
 Leu Ser Glu Gly Glu Leu Gly Gly Pro Ser Glu Pro Gly Gly Thr His
                 405                 410                 415    
 Pro Glu Asp His Gln Gly His Ser Asp Gln His His His His His His
             420                 425                 430        
 His His His Gly Arg Asp Phe Leu Leu Arg Ala Ala Ser Phe Asp Val
         435                 440                 445            
 Cys Glu Ser Val Asp Glu Ala Gly Gly Ser Gly Pro Ala Gly Leu Arg
     450                 455                 460                
 Ala Ser Thr Ser Asp Gly Ile Leu Arg Gly Asn Gly Thr Gly Tyr Leu
 465                 470                 475                 480
 Pro Gly Arg Gly Arg Val Leu Ser Ser Trp Ser Arg Ala Phe Val Ser
                 485                 490                 495    
 Ile Gln Glu Glu Met Ala Glu Asp Pro Leu Thr Tyr Lys Ser Arg Leu
             500                 505                 510        
 Met Val Val Val Lys Met Asp Ser Ser Ile Gln Pro Gly Pro Phe Arg
         515                 520                 525            
 Ala Val Leu Lys Tyr Leu Tyr Thr Gly Glu Leu Asp Glu Asn Glu Arg
     530                 535                 540                
 Asp Leu Met His Ile Ala His Ile Ala Glu Leu Leu Glu Val Phe Asp
 545                 550                 555                 560
 Leu Arg Met Met Val Ala Asn Ile Leu Asn Asn Glu Ala Phe Met Asn
                 565                 570                 575    
 Gln Glu Ile Thr Lys Ala Phe His Val Arg Arg Thr Asn Arg Val Lys
             580                 585                 590        
 Glu Cys Leu Ala Lys Gly Thr Phe Ser Asp Val Thr Phe Ile Leu Asp
         595                 600                 605            
 Asp Gly Thr Ile Ser Ala His Lys Pro Leu Leu Ile Ser Ser Cys Asp
     610                 615                 620                
 Trp Met Ala Ala Met Phe Gly Gly Pro Phe Val Glu Ser Ser Thr Arg
 625                 630                 635                 640
 Glu Val Val Phe Pro Tyr Thr Ser Lys Ser Cys Met Arg Ala Val Leu
                 645                 650                 655    
 Glu Tyr Leu Tyr Thr Gly Met Phe Thr Ser Ser Pro Asp Leu Asp Asp
             660                 665                 670        
 Met Lys Leu Ile Ile Leu Ala Asn Arg Leu Cys Leu Pro His Leu Val
         675                 680                 685            
 Ala Leu Thr Glu Gln Tyr Thr Val Thr Gly Leu Met Glu Ala Thr Gln
     690                 695                 700                
 Met Met Val Asp Ile Asp Gly Asp Val Leu Val Phe Leu Glu Leu Ala
 705                 710                 715                 720
 Gln Phe His Cys Ala Tyr Gln Leu Ala Asp Trp Cys Leu His His Ile
                 725                 730                 735    
 Cys Thr Asn Tyr Asn Asn Val Cys Arg Lys Phe Pro Arg Asp Met Lys
             740                 745                 750        
 Ala Met Ser Pro Glu Asn Gln Glu Tyr Phe Glu Lys His Arg Trp Pro
         755                 760                 765            
 Pro Val Trp Tyr Leu Lys Glu Glu Asp His Tyr Gln Arg Ala Arg Lys
     770                 775                 780                
 Glu Arg Glu Lys Glu Asp Tyr Leu His Leu Lys Arg Gln Pro Lys Arg
 785                 790                 795                 800
 Arg Trp Leu Phe Trp Asn Ser Pro Ser Ser Pro Ser Ser Ser Ala Ala
                 805                 810                 815    
 Ser Ser Ser Ser Pro Ser Ser Ser Ser Ala Val Val
             820                 825            



      <210> 897
      <211> 583
      <212> PRT
      <213> Homo sapiens


      <400> 897
 Met Cys Gln Leu Pro Glu Ala Gln Ser Gln Gly Pro Ser His Ile Ser
   1               5                  10                  15    
 Cys Leu Arg Ala Phe Leu Thr Ser Trp Pro Trp Ala Lys Leu Leu Ser
              20                  25                  30        
 Leu Ser Arg Leu Pro Ser Met Leu Glu Asp Gln Val Gln Glu Met Pro
          35                  40                  45            
 Leu Pro Asp Gln Pro Arg Thr Ala Val Ser Ile Pro Arg Pro Gln Cys
      50                  55                  60                
 Gly Leu Trp Gly Cys Val Gln Ser Val Arg Asp Ala Met Ser Ser Lys
  65                  70                  75                  80
 Gly Ser Val Val Leu Ala Tyr Ser Gly Gly Leu Asp Thr Ser Cys Ile
                  85                  90                  95    
 Leu Val Trp Leu Lys Glu Gln Gly Tyr Asp Val Ile Ala Tyr Leu Ala
             100                 105                 110        
 Asn Ile Gly Gln Lys Glu Asp Phe Glu Glu Ala Arg Lys Lys Ala Leu
         115                 120                 125            
 Lys Leu Gly Ala Lys Lys Val Phe Ile Glu Asp Val Ser Arg Glu Phe
     130                 135                 140                
 Val Glu Glu Phe Ile Trp Pro Ala Ile Gln Ser Ser Ala Leu Tyr Glu
 145                 150                 155                 160
 Asp Arg Tyr Leu Leu Gly Thr Ser Leu Ala Arg Pro Cys Ile Ala Arg
                 165                 170                 175    
 Lys Gln Val Glu Ile Ala Gln Arg Glu Gly Ala Lys Tyr Val Ser His
             180                 185                 190        
 Gly Ala Thr Gly Lys Gly Asn Asp Gln Val Arg Phe Glu Leu Ser Cys
         195                 200                 205            
 Tyr Ser Leu Ala Pro Gln Ile Lys Val Ile Ala Pro Trp Arg Met Pro
     210                 215                 220                
 Glu Phe Tyr Asn Arg Phe Lys Gly Arg Asn Asp Leu Met Glu Tyr Ala
 225                 230                 235                 240
 Lys Gln His Gly Ile Pro Ile Pro Val Thr Pro Lys Asn Pro Trp Ser
                 245                 250                 255    
 Met Asp Glu Asn Leu Met His Ile Ser Tyr Glu Ala Gly Ile Leu Glu
             260                 265                 270        
 Asn Pro Lys Asn Gln Ala Pro Pro Gly Leu Tyr Thr Lys Thr Gln Asp
         275                 280                 285            
 Pro Ala Lys Ala Pro Asn Thr Pro Asp Ile Leu Glu Ile Glu Phe Lys
     290                 295                 300                
 Lys Gly Val Pro Val Lys Val Thr Asn Val Lys Asp Gly Thr Thr His
 305                 310                 315                 320
 Gln Thr Ser Leu Glu Leu Phe Met Tyr Leu Asn Glu Val Ala Gly Lys
                 325                 330                 335    
 His Gly Val Gly Arg Ile Asp Ile Val Glu Asn Arg Phe Ile Gly Met
             340                 345                 350        
 Lys Ser Arg Gly Ile Tyr Glu Thr Pro Ala Gly Thr Ile Leu Tyr His
         355                 360                 365            
 Ala His Leu Asp Ile Glu Ala Phe Thr Met Asp Arg Glu Val Arg Lys
     370                 375                 380                
 Ile Lys Gln Gly Leu Gly Leu Lys Phe Ala Glu Leu Val Tyr Thr Gly
 385                 390                 395                 400
 Phe Trp His Ser Pro Glu Cys Glu Phe Val Arg His Cys Ile Ala Lys
                 405                 410                 415    
 Ser Gln Glu Arg Val Glu Gly Lys Val Gln Val Ser Val Leu Lys Gly
             420                 425                 430        
 Gln Val Tyr Ile Leu Gly Arg Glu Ser Pro Leu Ser Leu Tyr Asn Glu
         435                 440                 445            
 Glu Leu Val Ser Met Asn Val Gln Gly Asp Tyr Glu Pro Thr Asp Ala
     450                 455                 460                
 Thr Gly Phe Ile Asn Ile Lys Phe Leu Ser Pro His Pro Val Thr Tyr
 465                 470                 475                 480
 Gln Ile Glu Ala Ser Leu Lys Pro Glu Gln Pro Gly Val Thr Leu Val
                 485                 490                 495    
 Ser Ile Pro Val Phe Leu Ala Pro Ser Trp His Lys Ala Ser Glu Leu
             500                 505                 510        
 Ile Pro Thr Gln Ser Phe Arg Ala Gln Ala Trp Gly Ser Val Arg Phe
         515                 520                 525            
 Met Ala Pro Leu Leu Gly Ala Ala Asp Pro Val His Pro Ala Trp Leu
     530                 535                 540                
 Gly Pro Pro Ile Cys Gln Cys Cys Val Gln Lys Pro His Val Ser Ser
 545                 550                 555                 560
 Val Leu Ala Val Asp Ile Leu Asp Val Arg Arg Gly Arg Asn Pro Ser
                 565                 570                 575    
 His His Leu Tyr Lys Lys Thr
             580            



      <210> 898
      <211> 250
      <212> PRT
      <213> Homo sapiens


      <400> 898
 Met Leu Arg Glu Asp Asp Arg Met Gly Gln Phe Gly Gly Pro Ala Gly
   1               5                  10                  15    
 Leu Ser Leu Ala Ser Thr Val Phe Gly Arg Asn Arg Ser Gly Asp Ser
              20                  25                  30        
 Leu Pro Ala Ser Asp Arg Pro Pro Ile Ser Ser Pro Leu Ala Thr Ser
          35                  40                  45            
 Gly Thr Ile Phe Ser Ala Ile Ser Cys Phe Trp Asp Leu Pro Ala Pro
      50                  55                  60                
 Phe Leu Trp Leu Ala Pro Ser Cys Gln Pro Thr Met Ser Ser Gln Ile
  65                  70                  75                  80
 Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val
                  85                  90                  95    
 Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr
             100                 105                 110        
 Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg
         115                 120                 125            
 Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met
     130                 135                 140                
 Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro
 145                 150                 155                 160
 Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met
                 165                 170                 175    
 Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu
             180                 185                 190        
 Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His
         195                 200                 205            
 Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu
     210                 215                 220                
 Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr
 225                 230                 235                 240
 Leu Phe Glu Arg Leu Thr Leu Lys His Asp
                 245                 250



      <210> 899
      <211> 516
      <212> PRT
      <213> Homo sapiens


      <400> 899
 Met Pro Cys His Pro Pro His Thr Arg Ala Ser Glu Pro Pro Gly Ala
   1               5                  10                  15    
 His Leu Gly Thr Gly Lys Val Pro Ala Trp Ser Leu Lys Ser Val Val
              20                  25                  30        
 Arg Cys Glu Gln Arg Arg Val Met Gln Gln Ala Cys Ala Tyr Pro Asp
          35                  40                  45            
 Arg Lys Lys Gly Met Gln Arg Leu Lys Asp Gly Val Cys Ser Ala Cys
      50                  55                  60                
 Ala Gln Thr Thr Gly Lys Gln Asp Cys Glu Asn Ala Trp Cys Val Pro
  65                  70                  75                  80
 Leu Ile Gln Val Glu Thr Glu Gln Pro Glu Glu Ser Phe Pro Asn Thr
                  85                  90                  95    
 Glu Thr Asn Gly Glu Phe Gly Lys Cys Pro Ala Glu Asp Met Glu Glu
             100                 105                 110        
 Glu Gln Ala Leu Lys Arg Ser Arg Asn Thr Asp Glu Met Val Glu Leu
         115                 120                 125            
 His Ile Leu Leu Gln Asn Lys Asn Ser Gly Ala Val Ile Gly Glu Gly
     130                 135                 140                
 Gly Lys Asn Ile Lys Ala Pro Cys Ile Asp Tyr Ser Ala Ser Val Ser
 145                 150                 155                 160
 Val Pro Asp Ser Ser Gly Pro Lys Cys Ile Leu Ser Ile Ser Ala Gly
                 165                 170                 175    
 Ile Glu Thr Ile Gly Glu Ile Leu Lys Lys Ile Ile Pro Thr Leu Glu
             180                 185                 190        
 Glu Gly Leu Gln Leu Pro Leu Leu Thr Pro Thr Ser Gln Leu Leu Leu
         195                 200                 205            
 Glu Ser Asp Ala Val Glu Cys Leu Asn Tyr Gln His Tyr Lys Gly Arg
     210                 215                 220                
 Asp Phe Glu Cys Glu Leu Lys Leu Leu Ile Tyr Gln Ser Leu Ala Gly
 225                 230                 235                 240
 Gly Ile Leu Gly Ser Lys Glu Cys Cys Ser His Pro Thr Asp Arg Val
                 245                 250                 255    
 Val Leu Ile Gly Gly Lys Pro Asn Arg Val Val Glu Cys Ile Lys Ile
             260                 265                 270        
 Ile Leu Asp Leu Ile Ser Glu Ser Pro Ile Lys Gly Pro Ala Gln Pro
         275                 280                 285            
 Tyr Asp Pro Ser Phe Tyr Asn Glu Thr Tyr Asp Tyr Gly Gly Phe Thr
     290                 295                 300                
 Met Met Phe Asp Asp Arg Pro Gly Cys Pro Val Gly Phe Pro Met Trp
 305                 310                 315                 320
 Gly Arg Gly Gly Phe Asp Arg Met Pro Pro Gly Trp Gly Gly Arg Pro
                 325                 330                 335    
 Met Pro Pro Ser Arg Arg Asp Met Ser Pro His Arg Gly Pro Pro Pro
             340                 345                 350        
 Pro Leu Thr Gly Arg Gly Gly Arg Gly Gly Ser Arg Ala Arg Asn Leu
         355                 360                 365            
 Pro Leu Pro Pro Pro Pro Pro Pro Arg Gly Glu Asp Leu Met Ala Tyr
     370                 375                 380                
 Asp Arg Arg Gly Arg Pro Gly Asp Cys Tyr Asp Gly Met Val Gly Phe
 385                 390                 395                 400
 Ser Pro Asp Glu Thr Trp Asn Ser Ala Ile Asp Thr Trp Ser Pro Ser
                 405                 410                 415    
 Glu Trp Gln Met Ala Tyr Glu Pro Gln Gly Gly Ser Gly Tyr Asp Tyr
             420                 425                 430        
 Ser Tyr Ala Gly Ile Gly Gly Ser Tyr Gly Asp Leu Gly Gly Pro Ile
         435                 440                 445            
 Thr Thr Ala Gln Val Thr Ile Pro Lys Asp Leu Thr Gly Ser Ile Ile
     450                 455                 460                
 Gly Lys Gly Gly Gln Arg Ile Lys Gln Ile Gly His Glu Leu Gly Ala
 465                 470                 475                 480
 Ser Ile Lys Ile Asp Glu Pro Leu Glu Gly Ser Glu Asp Gln Ile Thr
                 485                 490                 495    
 Ile Ile Thr Gly Thr Gln Asp Gln Ile Gln Asn Ala Gln Tyr Leu Leu
             500                 505                 510        
 Gln Asn Asn Val
         515    



      <210> 900
      <211> 260
      <212> PRT
      <213> Homo sapiens


      <400> 900
 Met Thr Gln Thr Pro Arg Gly Ala Ser Ser Ala Gly Ala Leu Pro Pro
   1               5                  10                  15    
 Thr Ser Trp Ser Pro Ala Ser Gly Arg Gly Glu Gly Gln Ser Arg Gly
              20                  25                  30        
 Pro Ala Ala Leu Ser Ser Ile Ser Leu Gln Gly Leu Gly Pro Thr Gly
          35                  40                  45            
 Pro Ala Leu Arg Arg Ala Leu Glu Cys Ala Ala Arg Gln Ser His Arg
      50                  55                  60                
 Thr Asp Ala Thr Ile Cys Gly Lys Asp Arg Gly Glu Glu Asp Leu Thr
  65                  70                  75                  80
 Leu Gln Gln Gln Asp Leu Thr Thr Thr Met Ser Ser Lys Arg Thr Lys
                  85                  90                  95    
 Thr Lys Thr Lys Lys Arg Pro Gln Arg Ala Thr Ser Asn Val Phe Ala
             100                 105                 110        
 Met Phe Asp Gln Ser Gln Ile Gln Glu Phe Lys Glu Ala Phe Asn Met
         115                 120                 125            
 Ile Asp Gln Asn Arg Asp Gly Phe Ile Asp Lys Glu Asp Leu His Asp
     130                 135                 140                
 Met Leu Ala Ser Leu Gly Lys Asn Pro Thr Asp Ala Tyr Leu Asp Ala
 145                 150                 155                 160
 Met Met Asn Glu Ala Pro Gly Pro Ile Asn Phe Thr Met Phe Leu Thr
                 165                 170                 175    
 Met Phe Gly Glu Lys Leu Asn Gly Thr Asp Pro Glu Asp Val Ile Arg
             180                 185                 190        
 Asn Ala Phe Ala Cys Phe Asp Glu Glu Ala Thr Gly Thr Ile Gln Glu
         195                 200                 205            
 Asp Tyr Leu Arg Glu Leu Leu Thr Thr Met Gly Asp Arg Phe Thr Asp
     210                 215                 220                
 Glu Glu Val Asp Glu Leu Tyr Arg Glu Ala Pro Ile Asp Lys Lys Gly
 225                 230                 235                 240
 Asn Phe Asn Tyr Ile Glu Phe Thr Arg Ile Leu Lys His Gly Ala Lys
                 245                 250                 255    
 Asp Lys Asp Asp
             260



      <210> 901
      <211> 267
      <212> PRT
      <213> Homo sapiens


      <400> 901
 Met Glu Ala Glu Asp Ile Gln Glu Glu Leu Thr Cys Pro Ile Cys Leu
   1               5                  10                  15    
 Asp Tyr Phe Gln Asp Pro Val Ser Ile Glu Cys Gly His Asn Phe Cys
              20                  25                  30        
 Arg Gly Cys Leu His Arg Asn Trp Ala Pro Gly Gly Gly Pro Phe Pro
          35                  40                  45            
 Cys Pro Glu Cys Arg His Pro Ser Ala Pro Ala Ala Leu Arg Pro Asn
      50                  55                  60                
 Trp Ala Leu Ala Arg Leu Thr Glu Lys Thr Gln Arg Arg Arg Leu Gly
  65                  70                  75                  80
 Pro Val Pro Pro Gly Leu Cys Gly Arg His Trp Glu Pro Leu Arg Leu
                  85                  90                  95    
 Phe Cys Glu Asp Asp Gln Arg Pro Val Cys Leu Val Cys Arg Glu Ser
             100                 105                 110        
 Gln Glu His Gln Thr His Ala Met Ala Pro Ile Asp Glu Ala Phe Glu
         115                 120                 125            
 Ser Tyr Arg Glu Lys Leu Leu Lys Ser Gln Arg Asn Leu Val Ala Lys
     130                 135                 140                
 Met Lys Lys Val Met His Leu Gln Asp Val Glu Val Lys Asn Ala Thr
 145                 150                 155                 160
 Gln Trp Lys Asp Lys Ile Lys Ser Gln Arg Met Arg Ile Ser Thr Glu
                 165                 170                 175    
 Phe Ser Lys Leu His Asn Phe Leu Val Glu Glu Glu Asp Leu Phe Leu
             180                 185                 190        
 Gln Arg Leu Asn Lys Glu Glu Glu Glu Thr Lys Lys Lys Leu Asn Glu
         195                 200                 205            
 Asn Thr Leu Lys Leu Asn Gln Thr Ile Ala Ser Leu Lys Lys Leu Ile
     210                 215                 220                
 Leu Glu Val Gly Glu Lys Ser Gln Ala Pro Thr Leu Glu Leu Leu Gln
 225                 230                 235                 240
 Val Arg Gln Leu Arg Val Gly Val Ile Ser Ser Ser Leu Thr Glu Leu
                 245                 250                 255    
 Ser Leu Val Phe Arg Ala Glu Cys Pro Ser Trp
             260                 265        



      <210> 902
      <211> 326
      <212> PRT
      <213> Homo sapiens


      <400> 902
 Met Asn Ser Gly Val Pro Ala Thr Leu Ala Val Arg Arg Val Lys Phe
   1               5                  10                  15    
 Phe Gly Gln His Gly Gly Glu Val Asn Ser Ser Ala Phe Ser Pro Asp
              20                  25                  30        
 Gly Gln Met Leu Leu Thr Gly Ser Glu Asp Gly Cys Val Tyr Gly Trp
          35                  40                  45            
 Glu Thr Arg Ser Gly Gln Leu Leu Trp Arg Leu Gly Gly His Thr Gly
      50                  55                  60                
 Pro Val Lys Phe Cys Arg Phe Ser Pro Asp Gly His Leu Phe Ala Ser
  65                  70                  75                  80
 Ala Ser Cys Asp Cys Thr Val Arg Leu Trp Asp Val Ala Arg Ala Lys
                  85                  90                  95    
 Cys Leu Arg Val Leu Lys Gly His Gln Arg Ser Val Glu Thr Val Ser
             100                 105                 110        
 Phe Ser Pro Asp Ser Arg Gln Leu Ala Ser Gly Gly Trp Asp Lys Arg
         115                 120                 125            
 Val Met Leu Trp Asp Val Gln Trp Pro His Thr His Leu Glu Leu Ser
     130                 135                 140                
 Gly Gly Lys Gly Met Asp Ser Gly Ser Arg Leu Asp Ala Glu Trp Val
 145                 150                 155                 160
 Glu Ser Trp Leu Gly Gln Thr His Arg Ser Cys Leu Gln Ala Thr Gly
                 165                 170                 175    
 Ser Trp Asp Ser Thr Val Arg Ile Trp Asp Leu Arg Met Val Thr Pro
             180                 185                 190        
 Ala Val Ser His Gln Ala Leu Glu Gly His Ser Gly Asn Ile Ser Cys
         195                 200                 205            
 Leu Cys Tyr Ser Ala Ser Gly Leu Leu Ala Ser Gly Ser Trp Asp Lys
     210                 215                 220                
 Thr Ile His Ile Trp Lys Pro Thr Thr Ser Ser Leu Leu Ile Gln Leu
 225                 230                 235                 240
 Lys Gly His Val Thr Trp Val Lys Ser Ile Ala Phe Ser Pro Asp Glu
                 245                 250                 255    
 Leu Trp Leu Ala Ser Ala Gly Tyr Ser Arg Met Val Lys Val Trp Asp
             260                 265                 270        
 Cys Asn Thr Gly Lys Cys Leu Glu Thr Leu Lys Gln Gly Val Leu Asp
         275                 280                 285            
 Val Ala His Thr Cys Ala Phe Thr Pro Asp Gly Lys Ile Leu Val Ser
     290                 295                 300                
 Gly Ala Ala Asp Gln Thr Arg Arg Gln Ile Ser Arg Thr Ser Lys Ser
 305                 310                 315                 320
 Pro Arg Asp Pro Gln Thr
                 325    



      <210> 903
      <211> 387
      <212> PRT
      <213> Homo sapiens


      <400> 903
 Met Ser Phe Thr Thr Arg Ser Ile Phe Ser Thr Asn Tyr Leu Phe Leu
   1               5                  10                  15    
 Gly Ser Val Gln Val Ser Asn Tyr Gly Ala Arg Pro Ala Ser Cys Met
              20                  25                  30        
 Ala Ser Val Tyr Ala Gly Ala Gly Gly Ser Gly Ser Arg Ile Ser Val
          35                  40                  45            
 Ser Arg Ser Thr Ser Phe Arg Gly Gly Met Gly Ser Gly Asp Leu Ala
      50                  55                  60                
 Ala Gly Met Ala Gly Gly Leu Ala Gly Met Gly Gly Ile Gln Asn Lys
  65                  70                  75                  80
 Lys Glu Thr Met Gln Ser Leu Asn Asp Arg Leu Ala Ser Tyr Leu Asp
                  85                  90                  95    
 Arg Val Arg Ser Leu Glu Thr Lys Asn Arg Lys Leu Glu Ser Lys Ile
             100                 105                 110        
 Arg Glu His Leu Glu Lys Lys Gly Leu Gln Val Arg Asp Trp Ser His
         115                 120                 125            
 Tyr Leu Lys Thr Ile Glu Asp Leu Arg Val Gln Ile Phe Ala Asn Thr
     130                 135                 140                
 Val Asp Asn Ala Gly Ile Val Leu Gln Ile Asp Asn Ala Cys Leu Ala
 145                 150                 155                 160
 Ala Asp Asp Phe Arg Val Lys Ser Leu Met Thr Asn Val Thr Trp Leu
                 165                 170                 175    
 Pro Leu Glu Thr Glu Met Glu Ala Leu Lys Glu Glu Leu Leu Phe Met
             180                 185                 190        
 Lys Lys Asn His Glu Glu Glu Val Lys Asp Leu Gln Ala Gln Ile Thr
         195                 200                 205            
 Ser Ser Gly Leu Thr Met Glu Leu Pro Gln Lys Ser Arg Glu Glu Pro
     210                 215                 220                
 Asp Lys Tyr Cys Ser Gln Gln Met Glu Glu Ser Thr Thr Val Val Thr
 225                 230                 235                 240
 Met Gln Ser Ala Lys Val Gly Ala Ala Glu Met Met Leu Met Lys Leu
                 245                 250                 255    
 Arg Arg Thr Val Gln Ser Leu Glu Ile Asp Leu Asp Ser Met Arg Asn
             260                 265                 270        
 Leu Lys Val Ser Leu Gly Asn Ser Leu Arg Glu Val Glu Ala His Tyr
         275                 280                 285            
 Thr Leu Gln Met Glu Gln Leu Asn Gly Ile Leu Leu His Leu Glu Ser
     290                 295                 300                
 Glu Leu Ala Gln Thr Gln Ala Glu Gly Gln Cys Gln Ala Gln Glu Tyr
 305                 310                 315                 320
 Lys Ala Leu Leu Asn Ile Lys Leu Lys Leu Glu Ala Glu Ile Thr Thr
                 325                 330                 335    
 Tyr His Cys Leu Leu Glu Asp Gly Lys Asp Phe Asn Leu Gly Asp Ala
             340                 345                 350        
 Leu Asp Ser Ser Asn Ser Met Gln Ile Ile Gln Lys Asn Thr Thr His
         355                 360                 365            
 Trp Ile Val Asp Gly Lys Val Val Ser Glu Asn Asn Asp Thr Lys Val
     370                 375                 380                
 Leu Arg His
 385        



      <210> 904
      <211> 575
      <212> PRT
      <213> Homo sapiens


      <400> 904
 Met Phe Gly Ile Gln Asp Thr Leu Gly Arg Gly Pro Thr Leu Lys Glu
   1               5                  10                  15    
 Lys Ser Leu Gly Ala Glu Met Asp Ser Val Arg Ser Trp Val Arg Asn
              20                  25                  30        
 Val Gly Val Val Asp Ala Asn Val Ala Ala Gln Ser Gly Val Ala Leu
          35                  40                  45            
 Ser Arg Ala His Phe Glu Lys Gln Pro Pro Ser Asn Leu Arg Lys Ser
      50                  55                  60                
 Asn Phe Phe His Phe Val Leu Ala Leu Tyr Asp Arg Gln Gly Gln Pro
  65                  70                  75                  80
 Val Glu Ile Glu Arg Thr Ala Phe Val Asp Phe Val Glu Asn Asp Lys
                  85                  90                  95    
 Glu Gln Gly Asn Glu Lys Thr Asn Asn Gly Thr His Tyr Lys Leu Gln
             100                 105                 110        
 Leu Leu Tyr Ser Asn Gly Val Arg Thr Glu Gln Asp Leu Tyr Val Arg
         115                 120                 125            
 Leu Ile Asp Ser Val Thr Lys Gln Pro Ile Ala Tyr Gly Gly Gln Asn
     130                 135                 140                
 Lys Asn Pro Glu Met Cys Arg Val Leu Leu Thr His Glu Val Met Cys
 145                 150                 155                 160
 Ser Arg Cys Cys Glu Lys Lys Ser Cys Gly Asn Arg Asn Glu Thr Pro
                 165                 170                 175    
 Ser Asp Pro Val Ile Ile Asp Arg Phe Phe Leu Lys Phe Phe Leu Lys
             180                 185                 190        
 Cys Asn Gln Asn Cys Leu Lys Thr Ala Gly Asn Pro Arg Asp Met Arg
         195                 200                 205            
 Arg Phe Gln Val Val Leu Ser Thr Thr Val Asn Val Asp Gly His Val
     210                 215                 220                
 Leu Ala Val Ser Asp Asn Met Phe Val His Asn Asn Ser Lys His Gly
 225                 230                 235                 240
 Arg Arg Ala Arg Arg Leu Asp Pro Ser Glu Ala Thr Pro Cys Ile Lys
                 245                 250                 255    
 Ala Ile Ser Pro Ser Glu Gly Trp Thr Thr Gly Gly Ala Met Val Ile
             260                 265                 270        
 Ile Ile Gly Asp Asn Phe Phe Asp Gly Leu Gln Val Val Phe Gly Thr
         275                 280                 285            
 Met Leu Val Trp Ser Glu Leu Ile Thr Pro His Ala Ile Arg Val Gln
     290                 295                 300                
 Thr Pro Pro Arg His Ile Pro Gly Val Val Glu Val Thr Leu Ser Tyr
 305                 310                 315                 320
 Lys Ser Lys Gln Phe Cys Lys Gly Ala Pro Gly Arg Phe Ile Tyr Thr
                 325                 330                 335    
 Ala Leu Asn Glu Pro Thr Ile Asp Tyr Gly Phe Gln Arg Leu Gln Lys
             340                 345                 350        
 Val Ile Pro Arg His Pro Gly Asp Pro Glu Arg Leu Ala Lys Glu Met
         355                 360                 365            
 Leu Leu Lys Arg Ala Ala Asp Leu Val Glu Ala Leu Tyr Gly Thr Pro
     370                 375                 380                
 His Asn Asn Gln Asp Ile Ile Leu Lys Arg Ala Ala Asp Ile Ala Glu
 385                 390                 395                 400
 Ala Leu Tyr Ser Val Pro Arg Asn Pro Ser Gln Leu Pro Ala Leu Ser
                 405                 410                 415    
 Ser Ser Pro Ala His Ser Gly Met Met Gly Ile Asn Ser Tyr Gly Ser
             420                 425                 430        
 Gln Leu Gly Val Ser Ile Ser Glu Ser Thr Gln Gly Asn Asn Gln Gly
         435                 440                 445            
 Tyr Ile Arg Asn Thr Ser Ser Ile Ser Pro Arg Gly Tyr Ser Ser Ser
     450                 455                 460                
 Ser Thr Pro Gln Gln Ser Asn Tyr Ser Thr Ser Ser Asn Ser Met Asn
 465                 470                 475                 480
 Gly Tyr Ser Asn Val Pro Met Ala Asn Leu Gly Val Pro Gly Ser Pro
                 485                 490                 495    
 Gly Phe Leu Asn Gly Ser Pro Thr Gly Ser Pro Tyr Gly Ile Met Ser
             500                 505                 510        
 Ser Ser Pro Thr Val Gly Ser Ser Ser Thr Ser Ser Ile Leu Pro Phe
         515                 520                 525            
 Ser Ser Ser Val Phe Pro Ala Val Lys Gln Lys Ser Ala Phe Ala Pro
     530                 535                 540                
 Val Ile Arg Pro Gln Gly Ser Pro Ser Pro Ala Cys Ser Ser Gly Asn
 545                 550                 555                 560
 Gly Asn Gly Phe Arg Ala Met Thr Gly Leu Val Val Pro Pro Met
                 565                 570                 575



      <210> 905
      <211> 204
      <212> PRT
      <213> Homo sapiens


      <400> 905
 Met Ala Thr Arg Val Arg Thr Ala Ser Ile Trp Val Pro Pro Leu Gln
   1               5                  10                  15    
 Glu Arg Asn Ser Ser Trp Asp Arg Ile Arg Lys Leu Gln Gly Gln Glu
              20                  25                  30        
 Ser Ile Leu Gly Gln Gly Thr Pro Gly Leu Gln Pro Leu Pro Gly Thr
          35                  40                  45            
 Pro Arg Gln Lys Gln Lys Ser Arg Arg Ile Glu Lys Val Leu Glu Trp
      50                  55                  60                
 Leu Phe Ile Ser Gln Glu Gln Pro Lys Ile Thr Lys Ser Trp Gly Pro
  65                  70                  75                  80
 Leu Ser Phe Met Asp Val Phe Val Asp Phe Thr Trp Glu Glu Trp Gln
                  85                  90                  95    
 Leu Leu Asp Pro Ala Gln Lys Cys Leu Tyr Arg Ser Val Met Leu Glu
             100                 105                 110        
 Asn Tyr Ser Asn Leu Val Ser Leu Gly Tyr Gln His Thr Lys Pro Asp
         115                 120                 125            
 Ile Ile Phe Lys Leu Glu Gln Gly Glu Glu Leu Cys Leu Val Gln Ala
     130                 135                 140                
 Gln Val Pro Asn Gln Thr Cys Pro Ile Leu Lys Ala Gly Lys Ser Lys
 145                 150                 155                 160
 Ala Lys Val Leu Ala Gly Leu Val Ser Gly Glu Gly Leu Leu Cys Ala
                 165                 170                 175    
 Ser Lys Met Thr Pro Cys Leu Leu His Pro Leu Glu Thr Gln Ser Gly
             180                 185                 190        
 Lys Leu Met Thr Leu Met Asp Trp His Gln Asp Lys
         195                 200                



      <210> 906
      <211> 176
      <212> PRT
      <213> Homo sapiens


      <400> 906
 Met Ala Ala Ala Gly Arg Gly Arg Glu Gln Asp Ser Ala Arg Phe Val
   1               5                  10                  15    
 Tyr Val Thr Arg Phe Gly Ser His Gln Cys Ser Gly Val Leu Gln Leu
              20                  25                  30        
 Gly Gly Arg Gly Ala Gln Gly Leu Trp Gly Gln Gly Pro Gly Ala Gly
          35                  40                  45            
 Cys Arg Gln Glu Lys Pro Arg Glu Ala Met Ala Val Ala Gly Val Gln
      50                  55                  60                
 Gly Gly Ser Glu Leu Pro Leu Gly Ser Gln Leu Arg Val Pro Thr Thr
  65                  70                  75                  80
 Pro Gly Val Glu Ala Ala Ala Ser Ala Ser Ser Gln Leu Arg Ala Ser
                  85                  90                  95    
 Arg Val Gln Ser Gly Thr Arg Gln Ser Ala Arg Ala Gly Leu Ile Gln
             100                 105                 110        
 Lys Asp Ala Ala Lys Lys Tyr Asp Phe Pro Ile Pro Leu Asn Glu Ala
         115                 120                 125            
 Ser Lys Ile Met Lys Lys Lys Lys Lys Val Leu Val Trp Asn Arg Val
     130                 135                 140                
 Tyr Lys Val Ile Ser Arg Met Leu Glu Glu Asn Glu Lys Tyr Arg His
 145                 150                 155                 160
 Arg Leu Lys Cys Gln Arg Leu Ser Ser Glu Ser Ser Asn Tyr Thr Arg
                 165                 170                 175    





      <210> 907
      <211> 176
      <212> PRT
      <213> Homo sapiens


      <400> 907
 Met Leu Ser Ser Phe Pro Val Val Leu Leu Glu Thr Met Ser His Tyr
   1               5                  10                  15    
 Thr Asp Glu Pro Arg Phe Thr Ile Glu Gln Ile Asp Leu Leu Gln Arg
              20                  25                  30        
 Leu Arg Arg Thr Gly Met Thr Lys His Glu Ile Leu His Ala Leu Glu
          35                  40                  45            
 Thr Leu Asp Arg Leu Asp Gln Glu His Ser Asp Lys Phe Gly Arg Arg
      50                  55                  60                
 Ser Ser Tyr Gly Gly Ser Ser Tyr Gly Asn Ser Thr Asn Asn Val Pro
  65                  70                  75                  80
 Ala Ser Ser Ser Thr Ala Thr Ala Ser Thr Gln Thr Gln His Ser Gly
                  85                  90                  95    
 Met Ser Pro Ser Pro Ser Asn Ser Tyr Asp Thr Ser Pro Gln Pro Cys
             100                 105                 110        
 Thr Thr Asn Gln Asn Gly Arg Glu Asn Asn Glu Arg Leu Ser Thr Ser
         115                 120                 125            
 Asn Gly Lys Met Ser Pro Thr Arg Tyr His Ala Asn Ser Met Gly Gln
     130                 135                 140                
 Arg Ser Tyr Ser Phe Glu Ala Ser Glu Glu Asp Leu Asp Val Asp Asp
 145                 150                 155                 160
 Lys Val Glu Glu Leu Met Arg Leu Val Thr Leu Leu Ile Gln Ser Pro
                 165                 170                 175    





      <210> 908
      <211> 272
      <212> PRT
      <213> Homo sapiens


      <400> 908
 Met Ser Lys Arg Gly Arg Gly Gly Ser Ser Gly Ala Lys Phe Arg Ile
   1               5                  10                  15    
 Ser Leu Gly Leu Pro Val Gly Ala Val Ile Asn Cys Ala Asp Asn Thr
              20                  25                  30        
 Gly Ala Lys Asn Leu Tyr Ile Ile Ser Val Lys Gly Ile Lys Gly Arg
          35                  40                  45            
 Leu Asn Arg Leu Pro Ala Ala Gly Val Gly Asp Met Val Met Ala Thr
      50                  55                  60                
 Val Lys Lys Gly Lys Pro Glu Leu Arg Lys Lys Val His Pro Ala Val
  65                  70                  75                  80
 Val Ile Arg Gln Arg Lys Ser Tyr Arg Arg Lys Asp Gly Val Phe Leu
                  85                  90                  95    
 Tyr Phe Glu Asp Asn Ala Gly Val Ile Val Asn Asn Lys Gly Glu Met
             100                 105                 110        
 Lys Gly Phe Ala Ile Thr Gly Pro Val Ala Lys Glu Cys Ala Asp Leu
         115                 120                 125            
 Trp Pro Arg Ile Ala Ser Asn Ala Gly Ser Ile Ala Leu Ile Leu Gln
     130                 135                 140                
 Tyr Ile Gly Thr His Ile Asn Lys Lys Leu Asn Pro Ile Asn Pro Thr
 145                 150                 155                 160
 Thr Thr Asn Asn Thr His Thr Thr Val Gly Gly Pro Glu His Arg Ala
                 165                 170                 175    
 Pro Gly Lys Arg Phe Ser Lys Thr His Leu Val Arg Pro Arg Gly Pro
             180                 185                 190        
 His Thr Leu His Arg Asn Arg Gly Pro Gln Pro Gly Pro Arg Glu Asp
         195                 200                 205            
 Arg Gly Thr Thr Lys Gly Arg Gly Ile His Thr Gln Asn Lys Lys Thr
     210                 215                 220                
 Pro Gly Gly Thr Thr Glu Ala Val Leu Gly Gln Gln Pro Pro Lys Gly
 225                 230                 235                 240
 Ala Pro Ala Arg Thr Asn Gly Pro His His Arg Gly Pro Gln Arg Pro
                 245                 250                 255    
 Glu Ile Lys Arg Ser Ser Arg Gly Arg Gln Asn His His Ile Asn Lys
             260                 265                 270        





      <210> 909
      <211> 117
      <212> PRT
      <213> Homo sapiens


      <400> 909
 Met Ala Tyr Gly Val Pro Arg Lys Asn Thr Val Lys Thr Ile Leu Arg
   1               5                  10                  15    
 Gly Ser Cys Tyr Asn Val Gln Glu Pro Trp Asp Ile Ala Leu Leu Ala
              20                  25                  30        
 Lys Thr Trp Tyr Thr Asn Leu Ala Asn Ile Lys Leu Pro Phe Leu Glu
          35                  40                  45            
 Glu Ile Ser Phe Gly Gly Ser Val Gln Leu Thr Lys Cys Thr Thr Ile
      50                  55                  60                
 Lys Asp Gly Leu Leu Pro Ser Ala Glu Ser Ile Lys Leu Glu Arg Glu
  65                  70                  75                  80
 Tyr Glu Val Lys Arg Leu Cys Lys Leu Lys Cys Gln Glu Asn Thr Ser
                  85                  90                  95    
 Lys Glu Ile Gln Leu Leu Leu Arg Glu Arg Pro Ala Gly Leu Arg Arg
             100                 105                 110        
 Pro Leu Pro Ser Lys
         115        



      <210> 910
      <211> 604
      <212> PRT
      <213> Homo sapiens


      <400> 910
 Met Leu Asp Thr Ile Ala Arg Ala Leu Gln Asp Leu Gly Arg Gln Val
   1               5                  10                  15    
 Leu Pro Thr Leu Pro Ser Leu Ser Gln Glu Glu Val Ser Ile Ile Trp
              20                  25                  30        
 Gly Asn Val Ser Glu Phe Val Arg Arg Gln Leu Thr Leu His Lys Gly
          35                  40                  45            
 Val Gln Ile Pro Ala Phe Gly Thr Phe Thr Phe Ile Arg Gln Lys Leu
      50                  55                  60                
 Glu Val Gly Asn Asn Lys Phe Ile Leu Ile Gln Arg Pro Val Phe Ile
  65                  70                  75                  80
 Met Val Glu Lys Leu Val Gln Ile His Gly Leu Lys Gln Asn Lys Val
                  85                  90                  95    
 Tyr Thr Pro Gly Glu Ile Pro Ile Val Pro Leu Asn Phe Val Met Ile
             100                 105                 110        
 Ser Leu Glu Gly Pro Phe Asn Arg Asp Val Val Glu Gly Cys Val Lys
         115                 120                 125            
 Glu Thr Leu Leu Phe Leu Ser Arg Ser Ile Ser Met Lys Gln Asn Val
     130                 135                 140                
 Glu Phe Thr Phe Lys Gly Ile Gly Val Leu Met Ile Arg Asp Ser Lys
 145                 150                 155                 160
 Val Lys Met Arg Phe Tyr Lys Asp Phe Leu Cys Thr Met Asp Gly Ser
                 165                 170                 175    
 Gly Ala Leu Ala Lys Ala Leu Ala Asn Arg Pro Gly Thr Val Asp Ser
             180                 185                 190        
 Val Leu Ser Ser Arg Glu Ala Leu Arg Lys Trp Pro Ser Ser Val Leu
         195                 200                 205            
 Ala Phe Pro Arg Ile Glu Leu Lys Glu Met Glu Asn Lys Leu Pro Met
     210                 215                 220                
 Glu Thr Leu Val Glu Glu Cys Gly Glu Asn Arg Glu Arg Lys Cys Lys
 225                 230                 235                 240
 Leu Lys Asp Gln Ser Asp Lys Glu Glu Gly Thr Arg Asp Ile Ser Ser
                 245                 250                 255    
 Pro Lys Arg Leu Arg Asp Arg Gln Ala Leu Phe Pro Ala Lys Val Thr
             260                 265                 270        
 Asn Val Ser Leu Leu Glu Lys Phe Glu Arg Ser Glu Ser Gly Gly Lys
         275                 280                 285            
 Ile Met Thr Pro Glu Ser Glu Glu Arg Arg Arg Glu Ile Glu Asp Glu
     290                 295                 300                
 Arg Leu Ile Gln Gln Tyr Gln Met Leu Lys Asp Gln Glu Ala Leu Phe
 305                 310                 315                 320
 Arg His Gln Met Lys Ser Leu Ala Thr Arg Glu Gln Asn Gln Lys Asn
                 325                 330                 335    
 Ala Ala Tyr Asn Leu Gly Val Ala Glu Ala Ile Arg Asn His Lys Asn
             340                 345                 350        
 Glu Lys Pro Glu Phe Tyr Lys Ser Phe Leu Phe Asp Lys Arg Pro Leu
         355                 360                 365            
 Ser Pro Ala Leu Asn Ala Leu Lys Gln Glu Glu Tyr Ser Arg Ser Leu
     370                 375                 380                
 Leu Lys Gln Met Asp Asn Arg Gln Glu Asn Glu Ile Lys Gln Arg Gln
 385                 390                 395                 400
 Tyr Arg Glu Leu Met Asp Arg Leu Glu Gln Val Gln Leu Thr Glu Glu
                 405                 410                 415    
 Leu Ala Ala Gln Arg Ala Lys Phe Leu Lys Asp Lys Met Glu Glu Thr
             420                 425                 430        
 Gln Cys Tyr Lys Arg Ala Leu Asp Ala Gln Ile Lys Asn Lys Pro Ser
         435                 440                 445            
 Arg Leu Pro Pro Phe Glu Pro Asp Ser Ser Glu Pro Ile Phe Gly Lys
     450                 455                 460                
 Asn Glu Gly Glu Leu Met Val Glu Lys Gln Lys Arg Glu Gln Asn Tyr
 465                 470                 475                 480
 Met Lys His Gln Leu Glu Ala Ala Ala Asn His Lys Arg Lys Ala Ile
                 485                 490                 495    
 Leu His Gln Leu Val Asp Gln Arg Arg Asp Leu Gln Met Leu Gln Arg
             500                 505                 510        
 Thr Gln Arg Glu His Leu Ala Asp Arg Thr Ala Glu Leu Glu Arg Val
         515                 520                 525            
 Asn Arg Val Asn Gln Cys Leu Gln Glu Asp Trp Glu Arg Ser Ala Ala
     530                 535                 540                
 Met Lys Lys Gln Arg Asp Leu Glu Asp Lys Ala Phe Glu Arg Ala Ser
 545                 550                 555                 560
 Asp Lys Leu Phe Leu Leu Asp Gln Cys Glu Lys Tyr Arg Arg Cys Lys
                 565                 570                 575    
 Gln Cys Gln Arg Arg Thr Ser Asn Val Gly Glu Ser Asn Leu Trp Pro
             580                 585                 590        
 Leu Asn Lys Phe Leu Pro Gly Ser Arg Leu Leu Val
         595                 600                



      <210> 911
      <211> 99
      <212> PRT
      <213> Homo sapiens


      <400> 911
 Met Trp Pro Gln Pro Arg Leu Pro Pro Arg Pro Ala Met Ser Glu Glu
   1               5                  10                  15    
 Thr Arg Gln Ser Lys Leu Ala Ala Ala Lys Lys Lys Leu Arg Glu Tyr
              20                  25                  30        
 Gln Gln Arg Asn Ser Pro Gly Val Pro Thr Gly Ala Lys Lys Lys Lys
          35                  40                  45            
 Lys Ile Lys Asn Gly Ser Asn Pro Glu Thr Thr Thr Ser Gly Gly Cys
      50                  55                  60                
 His Ser Pro Glu Asp Val Ser Leu Gly Trp Pro Gly Ser Trp Gly Gln
  65                  70                  75                  80
 Gly Ala Gln Gly Ala Val Glu Gly Asn Cys Tyr Asp Cys Gly Arg Thr
                  85                  90                  95    
 Val Gly Tyr
            



      <210> 912
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 912
 Met Ile Lys Gly Leu Ile His Gln Glu Asp Ile Thr Ile Val Lys Val
   1               5                  10                  15    
 Tyr Ala Pro Asn Ile Asp Pro Pro Lys Tyr Ile Lys Gln Phe Leu Asn
              20                  25                  30        
 Asp Val Lys Arg Glu Ile Gly Cys Asn Thr Ile Ile Arg Asp Leu Asn
          35                  40                  45            
 Thr Leu Leu Phe Thr Met Gly Arg Leu Ile Pro Arg Gln Lys Ser Asn
      50                  55                  60                
 Lys Glu Thr Met Asp Phe Asn Tyr Thr Leu Asp Gln Thr Asp Leu Thr
  65                  70                  75                  80
 Gly Ile Tyr Glu Thr Phe His Pro Glu Ala Ala Lys Tyr Ile Leu Phe
                  85                  90                  95    
 Ser Asn Ala His Gly Thr Phe Ser Arg Ile Tyr Val Ser Pro Gln Asn
             100                 105                 110        





      <210> 913
      <211> 126
      <212> PRT
      <213> Homo sapiens


      <400> 913
 Met Gly Ser Pro Pro Gln Val His Thr His Thr His Val Trp Ile His
   1               5                  10                  15    
 Leu His Ser His Ala Trp Val His Pro His Ala Phe Thr His Thr Cys
              20                  25                  30        
 Val Gly Ser Pro Thr Leu Thr Leu Met Leu Gly Phe Thr His Thr His
          35                  40                  45            
 Ser His Thr His Ala Trp Val His Pro His Ser His Thr Pro Thr Arg
      50                  55                  60                
 Gly Phe Thr Arg Met Tyr Ser His Ala His Ser Arg Val Gly Ser Pro
  65                  70                  75                  80
 Ala His Thr His Met His Thr His Thr Trp Val His Pro His Ala His
                  85                  90                  95    
 Thr His Arg Ala His Ser Gly Ala Cys Met Asp Thr Val Arg Pro Val
             100                 105                 110        
 Leu Ser Glu Val Arg Trp Arg Ala Ser Phe Trp Glu Leu Pro
         115                 120                 125    



      <210> 914
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 914
 Met Met Leu Arg Val Pro Gly Ser Gly Ser Phe Met Met Gln Arg Val
   1               5                  10                  15    
 Pro Leu Ser His Leu Gly Arg Leu Pro Ala Pro Ala Ser Ser Trp Gln
              20                  25                  30        
 Pro Gly Gly Arg Leu Arg Thr Arg Arg Pro Ala Thr Ile Leu Ser Val
          35                  40                  45            
 Ala Ala Ala Trp Gln Arg Ala Ser Leu Gly Gln Leu Val Ser Cys Gly
      50                  55                  60                
 Arg Val Ala Ala Thr Arg Ser Ser Thr Gln Asp Ser Leu Val Glu Pro
  65                  70                  75                  80
 Leu Val Cys Arg Leu Gln Val Leu Phe Leu Lys Lys Ala Gly Ser Glu
                  85                  90                  95    
 Arg Pro Cys Glu Thr Thr Pro Gly Ala Lys Gly Asp Ser His Lys Thr
             100                 105                 110        
 Gln Val Leu Leu Glu His Arg Lys Val Ser Leu Gln Val Glu Glu Gly
         115                 120                 125            
 Arg Glu Ser Ser Phe Pro His Leu His Gly Cys Leu Val Ala Arg Ile
     130                 135                 140                
 Arg Cys
 145    



      <210> 915
      <211> 267
      <212> PRT
      <213> Homo sapiens


      <400> 915
 Met Cys Ile His Glu Gly Leu Gln Ser Arg Gln Ile Thr Leu His Phe
   1               5                  10                  15    
 Asn Asp His Ser Lys Thr Ser Lys Ile Arg Thr Lys Lys Asn Lys Asp
              20                  25                  30        
 Pro Thr Gln Trp Ile Ala Thr Phe Gly Ala Thr Ile Thr Pro Pro Ala
          35                  40                  45            
 Val Lys Arg Asn Val Arg Lys Ile Ile Leu His Glu Asn Tyr His Arg
      50                  55                  60                
 Glu Thr Asn Glu Asn Asp Ile Ala Leu Val Gln Leu Ser Thr Gly Val
  65                  70                  75                  80
 Glu Phe Ser Asn Ile Val Gln Arg Val Cys Leu Pro Asp Ser Ser Ile
                  85                  90                  95    
 Lys Leu Pro Pro Lys Thr Ser Val Phe Val Thr Gly Phe Gly Ser Ile
             100                 105                 110        
 Val Asp Asp Gly Pro Ile Gln Asn Thr Leu Arg Gln Ala Arg Val Glu
         115                 120                 125            
 Thr Ile Ser Thr Asp Val Cys Asn Arg Lys Asp Val Tyr Asp Gly Leu
     130                 135                 140                
 Ile Thr Pro Gly Met Leu Cys Ala Gly Phe Met Glu Gly Lys Ile Asp
 145                 150                 155                 160
 Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Tyr Asp Asn His Asp
                 165                 170                 175    
 Ile Trp Tyr Ile Val Gly Ile Val Ser Trp Gly Gln Ser Cys Ala Leu
             180                 185                 190        
 Pro Lys Lys Pro Gly Val Tyr Thr Arg Val Thr Lys Tyr Arg Asp Trp
         195                 200                 205            
 Ile Ala Ser Lys Thr Gly Ser Ser Ser Leu Arg Thr Asp Thr Asn Glu
     210                 215                 220                
 Leu Pro Gly Gln Ile Ser Ser Ala Gln Val Ser Leu Pro Glu Glu Lys
 225                 230                 235                 240
 Gln Ile Lys Gly His Arg Met Phe Tyr Glu Asn Leu Trp Cys Val Lys
                 245                 250                 255    
 Ser Leu Pro Leu Lys Glu Met Asn Ile Arg Ala
             260                 265        



      <210> 916
      <211> 308
      <212> PRT
      <213> Homo sapiens


      <400> 916
 Met Lys Leu Thr Asp Ser Val Leu Arg Ser Phe Arg Val Ala Lys Val
   1               5                  10                  15    
 Phe Arg Glu Asn Ser Asp Lys Ile Asn Cys Phe Asp Phe Ser Pro Asn
              20                  25                  30        
 Gly Glu Thr Val Ile Ser Ser Ser Asp Asp Asp Ser Ile Val Leu Tyr
          35                  40                  45            
 Asp Cys Gln Glu Gly Lys Pro Lys Arg Thr Leu Tyr Ser Lys Lys Tyr
      50                  55                  60                
 Gly Val Asp Leu Ile Arg Tyr Thr His Ala Ala Asn Thr Val Val Tyr
  65                  70                  75                  80
 Ser Ser Asn Lys Ile Asp Asp Thr Ile Arg Tyr Leu Ser Leu His Asp
                  85                  90                  95    
 Asn Lys Tyr Ile Arg Tyr Phe Pro Gly His Ser Lys Arg Val Val Ala
             100                 105                 110        
 Leu Ser Met Ser Pro Val Asp Asp Thr Phe Ile Ser Gly Ser Leu Asp
         115                 120                 125            
 Lys Thr Ile Arg Leu Trp Asp Leu Arg Ser Pro Asn Cys Gln Gly Leu
     130                 135                 140                
 Met His Leu Gln Gly Lys Pro Val Cys Ser Phe Asp Pro Glu Gly Leu
 145                 150                 155                 160
 Ile Phe Ala Ala Gly Val Asn Ser Glu Met Val Lys Leu Tyr Asp Leu
                 165                 170                 175    
 Arg Ser Phe Asp Lys Gly Pro Phe Ala Thr Phe Lys Met Gln Tyr Asp
             180                 185                 190        
 Arg Thr Cys Glu Trp Thr Gly Leu Lys Phe Ser Asn Asp Gly Lys Leu
         195                 200                 205            
 Ile Leu Ile Ser Thr Asn Gly Ser Phe Ile Arg Leu Ile Asp Ala Phe
     210                 215                 220                
 Lys Gly Val Val Met His Thr Phe Gly Gly Tyr Ala Asn Ser Lys Ala
 225                 230                 235                 240
 Val Thr Leu Glu Ala Ser Phe Thr Pro Asp Ser Gln Phe Ile Met Ile
                 245                 250                 255    
 Gly Ser Glu Asp Gly Lys Ile His Val Trp Asn Gly Glu Ser Gly Ile
             260                 265                 270        
 Lys Val Ala Val Leu Asp Gly Lys His Thr Gly Pro Ile Thr Cys Leu
         275                 280                 285            
 Gln Phe Asn Pro Lys Phe Met Thr Phe Ala Ser Ala Cys Ser Asn Met
     290                 295                 300                
 Val Cys Glu Gln
 305            



      <210> 917
      <211> 216
      <212> PRT
      <213> Homo sapiens


      <400> 917
 Met Val Gly His Leu His Leu Gln Gly Met Glu Asp Ser Leu Lys Glu
   1               5                  10                  15    
 Gln Gly Arg Glu Gly Leu Leu Asp Ser Pro Asp Ser Gly Leu Pro Pro
              20                  25                  30        
 Ser Pro Ser Pro Ser Pro Pro Phe Tyr Ser Leu Ala Pro Gly Ile Leu
          35                  40                  45            
 Asp Ala Arg Ala Gly Gly Ala Gly Ala Ser Ser Glu Pro Pro Gly Pro
      50                  55                  60                
 Ser Glu Ala Arg Arg Ala Pro Ser Gln Leu Pro Asn Pro Pro Ala Ser
  65                  70                  75                  80
 Glu Met Arg Pro Arg Met Leu Pro Val Phe Phe Gly Glu Ser Ile Lys
                  85                  90                  95    
 Val Asn Pro Glu Pro Thr His Glu Ile Arg Cys Asn Ser Glu Val Lys
             100                 105                 110        
 Tyr Ala Ser Glu Lys His Phe Gln Asp Lys Val Phe Tyr Ala Pro Val
         115                 120                 125            
 Pro Thr Val Thr Ala Tyr Ser Glu Thr Ile Val Ala Ala Pro Asn Cys
     130                 135                 140                
 Thr Trp Arg Asn Tyr Arg Ser Gln Leu Thr Leu Glu Pro Arg Pro Arg
 145                 150                 155                 160
 Ala Leu Arg Phe Arg Ser Thr Thr Ile Ile Phe Pro Lys His Ala Arg
                 165                 170                 175    
 Ser Thr Phe Arg Thr Thr Leu His Cys Ser Leu Gly Arg Pro Ser Arg
             180                 185                 190        
 Trp Phe Thr Ala Ser Val Gln Leu Gln Leu Cys Gln Asp Pro Ala Pro
         195                 200                 205            
 Ser Leu Leu Gly Pro Ala Thr Leu
     210                 215    



      <210> 918
      <211> 810
      <212> PRT
      <213> Homo sapiens


      <400> 918
 Met Thr Thr Glu Lys Ser Leu Val Thr Glu Ala Glu Asn Ser Gln His
   1               5                  10                  15    
 Gln Gln Lys Glu Glu Gly Glu Glu Ala Ile Asn Ser Gly Gln Gln Glu
              20                  25                  30        
 Pro Gln Gln Glu Glu Ser Cys Gln Thr Ala Ala Glu Gly Asp Asn Trp
          35                  40                  45            
 Cys Glu Gln Lys Leu Lys Ala Ser Asn Gly Asp Thr Pro Thr His Glu
      50                  55                  60                
 Asp Leu Thr Lys Asn Lys Glu Arg Thr Ser Glu Ser Arg Gly Leu Ser
  65                  70                  75                  80
 Arg Leu Phe Ser Ser Phe Leu Lys Arg Pro Lys Ser Gln Val Ser Glu
                  85                  90                  95    
 Glu Glu Gly Lys Glu Val Glu Ser Asp Lys Glu Lys Gly Glu Gly Gly
             100                 105                 110        
 Gln Lys Glu Ile Glu Phe Gly Thr Ser Leu Asp Glu Glu Ile Ile Leu
         115                 120                 125            
 Lys Ala Pro Ile Ala Ala Pro Glu Pro Glu Leu Lys Thr Asp Pro Ser
     130                 135                 140                
 Leu Asp Leu His Ser Leu Ser Ser Ala Glu Thr Gln Pro Ala Gln Glu
 145                 150                 155                 160
 Glu Leu Arg Glu Asp Pro Asp Phe Glu Ile Lys Glu Gly Glu Gly Leu
                 165                 170                 175    
 Glu Glu Cys Ser Lys Ile Glu Val Lys Glu Glu Ser Pro Gln Ser Lys
             180                 185                 190        
 Ala Glu Thr Glu Leu Lys Ala Ser Gln Lys Pro Ile Arg Lys His Arg
         195                 200                 205            
 Asn Met His Cys Lys Val Ser Leu Leu Asp Asp Thr Val Tyr Glu Cys
     210                 215                 220                
 Val Val Glu Lys His Ala Lys Gly Gln Asp Leu Leu Lys Arg Val Cys
 225                 230                 235                 240
 Glu His Leu Asn Leu Leu Glu Glu Asp Tyr Phe Gly Leu Ala Ile Trp
                 245                 250                 255    
 Asp Asn Ala Thr Ser Lys Thr Trp Leu Asp Ser Ala Lys Glu Ile Lys
             260                 265                 270        
 Lys Gln Val Arg Gly Val Pro Trp Asn Phe Thr Phe Asn Val Lys Phe
         275                 280                 285            
 Tyr Pro Pro Asp Pro Ala Gln Leu Thr Glu Asp Ile Thr Arg Tyr Tyr
     290                 295                 300                
 Leu Cys Leu Gln Leu Arg Gln Asp Ile Val Ala Gly Arg Leu Pro Cys
 305                 310                 315                 320
 Ser Phe Ala Thr Leu Ala Leu Leu Gly Ser Tyr Thr Ile Gln Ser Glu
                 325                 330                 335    
 Leu Gly Asp Tyr Asp Pro Glu Leu His Gly Val Asp Tyr Val Ser Asp
             340                 345                 350        
 Phe Lys Leu Ala Pro Asn Gln Thr Lys Glu Leu Glu Glu Lys Val Met
         355                 360                 365            
 Glu Leu His Lys Ser Tyr Arg Ser Met Thr Pro Ala Gln Ala Asp Leu
     370                 375                 380                
 Glu Phe Leu Glu Asn Ala Lys Lys Leu Ser Met Tyr Gly Val Asp Leu
 385                 390                 395                 400
 His Lys Ala Lys Asp Leu Glu Gly Val Asp Ile Ile Leu Gly Val Cys
                 405                 410                 415    
 Ser Ser Gly Leu Leu Val Tyr Lys Asp Lys Leu Arg Ile Asn Arg Phe
             420                 425                 430        
 Pro Trp Pro Lys Val Leu Lys Ile Ser Tyr Lys Arg Ser Ser Phe Phe
         435                 440                 445            
 Ile Lys Ile Arg Pro Gly Glu Gln Glu Gln Tyr Glu Ser Thr Ile Gly
     450                 455                 460                
 Phe Lys Leu Pro Ser Tyr Arg Ala Ala Lys Lys Leu Trp Lys Val Cys
 465                 470                 475                 480
 Val Glu His His Thr Phe Phe Arg Leu Thr Ser Thr Asp Thr Ile Pro
                 485                 490                 495    
 Lys Ser Lys Phe Leu Ala Leu Gly Ser Lys Phe Arg Tyr Ser Gly Arg
             500                 505                 510        
 Thr Gln Ala Gln Thr Arg Gln Ala Ser Ala Leu Ile Asp Arg Pro Ala
         515                 520                 525            
 Pro His Phe Glu Arg Thr Ala Ser Lys Arg Ala Ser Arg Ser Leu Asp
     530                 535                 540                
 Gly Ala Ala Ala Val Asp Ser Ala Asp Arg Ser Pro Arg Pro Thr Ser
 545                 550                 555                 560
 Ala Pro Ala Ile Thr Gln Gly Gln Val Ala Glu Gly Gly Val Leu Asp
                 565                 570                 575    
 Ala Ser Ala Lys Lys Thr Val Val Pro Lys Ala Gln Lys Glu Thr Val
             580                 585                 590        
 Lys Ala Glu Val Lys Lys Glu Asp Glu Pro Pro Glu Gln Ala Glu Pro
         595                 600                 605            
 Glu Pro Thr Glu Ala Trp Lys Asp Leu Asp Lys Ser Gln Glu Glu Ile
     610                 615                 620                
 Lys Lys His His Ala Ser Ile Ser Glu Leu Lys Lys Asn Phe Met Glu
 625                 630                 635                 640
 Ser Val Pro Glu Pro Arg Pro Ser Glu Trp Asp Lys Arg Leu Ser Thr
                 645                 650                 655    
 His Ser Pro Phe Arg Thr Leu Asn Ile Asn Gly Gln Ile Pro Thr Gly
             660                 665                 670        
 Glu Gly Pro Pro Leu Val Lys Thr Gln Thr Val Thr Ile Ser Asp Asn
         675                 680                 685            
 Ala Asn Ala Val Lys Ser Glu Ile Pro Thr Lys Asp Val Pro Ile Val
     690                 695                 700                
 His Thr Glu Thr Lys Thr Ile Thr Tyr Glu Ala Ala Gln Thr Asp Asp
 705                 710                 715                 720
 Asn Ser Gly Asp Leu Asp Pro Gly Val Leu Leu Thr Ala Gln Thr Ile
                 725                 730                 735    
 Thr Ser Glu Thr Pro Ser Ser Thr Thr Thr Thr Lys Ile Thr Lys Thr
             740                 745                 750        
 Val Lys Gly Gly Ile Ser Glu Thr Arg Ile Glu Lys Arg Ile Val Ile
         755                 760                 765            
 Thr Gly Asp Ala Asp Ile Asp His Asp Gln Val Leu Val Gln Ala Ile
     770                 775                 780                
 Lys Glu Ala Lys Glu Gln His Pro Asp Met Ser Val Thr Lys Val Val
 785                 790                 795                 800
 Val His Gln Glu Thr Glu Ile Ala Asp Glu
                 805                 810



      <210> 919
      <211> 762
      <212> PRT
      <213> Homo sapiens


      <400> 919
 Met Thr Thr Glu Lys Ser Leu Val Thr Glu Ala Glu Asn Ser Gln His
   1               5                  10                  15    
 Gln Gln Lys Glu Glu Gly Glu Glu Ala Ile Asn Ser Gly Gln Gln Glu
              20                  25                  30        
 Pro Gln Gln Glu Glu Ser Cys Gln Thr Ala Ala Glu Gly Asp Asn Trp
          35                  40                  45            
 Cys Glu Gln Lys Leu Lys Ala Ser Asn Gly Asp Thr Pro Thr His Glu
      50                  55                  60                
 Asp Leu Thr Lys Asn Lys Glu Arg Thr Ser Glu Ser Arg Gly Leu Ser
  65                  70                  75                  80
 Arg Leu Phe Ser Ser Phe Leu Lys Arg Pro Lys Ser Gln Val Ser Glu
                  85                  90                  95    
 Glu Glu Gly Lys Glu Val Glu Ser Asp Lys Glu Lys Gly Glu Gly Gly
             100                 105                 110        
 Gln Lys Glu Ile Glu Phe Gly Thr Ser Leu Asp Glu Glu Ile Ile Leu
         115                 120                 125            
 Lys Ala Pro Ile Ala Ala Pro Glu Pro Glu Leu Lys Thr Asp Pro Ser
     130                 135                 140                
 Leu Asp Leu His Ser Leu Ser Ser Ala Glu Thr Gln Pro Ala Gln Glu
 145                 150                 155                 160
 Glu Leu Arg Glu Asp Pro Asp Phe Glu Ile Lys Glu Gly Glu Gly Leu
                 165                 170                 175    
 Glu Glu Cys Ser Lys Ile Glu Val Lys Glu Glu Ser Pro Gln Ser Lys
             180                 185                 190        
 Ala Glu Thr Glu Leu Lys Ala Ser Gln Lys Pro Ile Arg Lys His Arg
         195                 200                 205            
 Asn Met His Cys Lys Val Ser Leu Leu Asp Asp Thr Val Tyr Glu Cys
     210                 215                 220                
 Val Val Glu Thr Trp Leu Asp Ser Ala Lys Glu Ile Lys Lys Gln Val
 225                 230                 235                 240
 Arg Gly Val Pro Trp Asn Phe Thr Phe Asn Val Lys Phe Tyr Pro Pro
                 245                 250                 255    
 Asp Pro Ala Gln Leu Thr Glu Asp Ile Thr Arg Tyr Tyr Leu Cys Leu
             260                 265                 270        
 Gln Leu Arg Gln Asp Ile Val Ala Gly Arg Leu Pro Cys Ser Phe Ala
         275                 280                 285            
 Thr Leu Ala Leu Leu Gly Ser Tyr Thr Ile Gln Ser Glu Leu Gly Asp
     290                 295                 300                
 Tyr Asp Pro Glu Leu His Gly Val Asp Tyr Val Ser Asp Phe Lys Leu
 305                 310                 315                 320
 Ala Pro Asn Gln Thr Lys Glu Leu Glu Glu Lys Val Met Glu Leu His
                 325                 330                 335    
 Lys Ser Tyr Arg Ser Met Thr Pro Ala Gln Ala Asp Leu Glu Phe Leu
             340                 345                 350        
 Glu Asn Ala Lys Lys Leu Ser Met Tyr Gly Val Asp Leu His Lys Ala
         355                 360                 365            
 Lys Asp Leu Glu Gly Val Asp Ile Ile Leu Gly Val Cys Ser Ser Gly
     370                 375                 380                
 Leu Leu Val Tyr Lys Asp Lys Leu Arg Ile Asn Arg Phe Pro Trp Pro
 385                 390                 395                 400
 Lys Val Leu Lys Ile Ser Tyr Lys Arg Ser Ser Phe Phe Ile Lys Ile
                 405                 410                 415    
 Arg Pro Gly Glu Gln Glu Gln Tyr Glu Ser Thr Ile Gly Phe Lys Leu
             420                 425                 430        
 Pro Ser Tyr Arg Ala Ala Lys Lys Leu Trp Lys Val Cys Val Glu His
         435                 440                 445            
 His Thr Phe Phe Arg Leu Thr Ser Thr Asp Thr Ile Pro Lys Ser Lys
     450                 455                 460                
 Phe Leu Ala Leu Gly Ser Lys Phe Arg Tyr Ser Gly Arg Thr Gln Ala
 465                 470                 475                 480
 Gln Thr Arg Gln Ala Ser Ala Leu Ile Asp Arg Pro Ala Pro His Phe
                 485                 490                 495    
 Glu Arg Thr Ala Ser Lys Arg Ala Ser Arg Ser Leu Asp Gly Ala Ala
             500                 505                 510        
 Ala Val Asp Ser Ala Asp Arg Ser Pro Arg Pro Thr Ser Ala Pro Ala
         515                 520                 525            
 Ile Thr Gln Gly Gln Val Ala Glu Gly Gly Val Leu Asp Ala Ser Ala
     530                 535                 540                
 Lys Lys Thr Val Val Pro Lys Ala Gln Lys Glu Thr Val Lys Ala Glu
 545                 550                 555                 560
 Val Lys Lys Glu Asp Glu Pro Pro Glu Gln Ala Glu Pro Glu Pro Thr
                 565                 570                 575    
 Glu Ala Trp Lys Lys Lys Arg Glu Arg Leu Asp Gly Glu Asn Ile Tyr
             580                 585                 590        
 Ile Arg His Ser Asn Leu Met Leu Glu Asp Leu Asp Lys Ser Gln Glu
         595                 600                 605            
 Glu Ile Lys Lys His His Ala Ser Ile Ser Glu Leu Lys Lys Asn Phe
     610                 615                 620                
 Met Glu Ser Val Pro Glu Pro Arg Pro Ser Glu Trp Asp Lys Arg Leu
 625                 630                 635                 640
 Ser Thr His Ser Pro Phe Arg Thr Leu Asn Ile Asn Gly Gln Ile Pro
                 645                 650                 655    
 Thr Gly Glu Gly Pro Pro Leu Val Lys Thr Gln Thr Val Thr Ile Ser
             660                 665                 670        
 Asp Asn Ala Asn Ala Val Lys Ser Glu Ile Pro Thr Lys Asp Val Pro
         675                 680                 685            
 Ile Val His Thr Glu Thr Lys Thr Ile Thr Tyr Glu Ala Ala Gln Thr
     690                 695                 700                
 Val Lys Gly Gly Ile Ser Glu Thr Arg Ile Glu Lys Arg Ile Val Ile
 705                 710                 715                 720
 Thr Gly Asp Ala Asp Ile Asp His Asp Gln Val Leu Val Gln Ala Ile
                 725                 730                 735    
 Lys Glu Ala Lys Glu Gln His Pro Asp Met Ser Val Thr Lys Val Val
             740                 745                 750        
 Val His Gln Glu Thr Glu Ile Ala Asp Glu
         755                 760        



      <210> 920
      <211> 797
      <212> PRT
      <213> Homo sapiens


      <400> 920
 Met Thr Thr Glu Lys Ser Leu Val Thr Glu Ala Glu Asn Ser Gln His
   1               5                  10                  15    
 Gln Gln Lys Glu Glu Gly Glu Glu Ala Ile Asn Ser Gly Gln Gln Glu
              20                  25                  30        
 Pro Gln Gln Glu Glu Ser Cys Gln Thr Ala Ala Glu Gly Asp Asn Trp
          35                  40                  45            
 Cys Glu Gln Lys Leu Lys Ala Ser Asn Gly Asp Thr Pro Thr His Glu
      50                  55                  60                
 Asp Leu Thr Lys Asn Lys Glu Arg Thr Ser Glu Ser Arg Gly Leu Ser
  65                  70                  75                  80
 Arg Leu Phe Ser Ser Phe Leu Lys Arg Pro Lys Ser Gln Val Ser Glu
                  85                  90                  95    
 Glu Glu Gly Lys Glu Val Glu Ser Asp Lys Glu Lys Gly Glu Gly Gly
             100                 105                 110        
 Gln Lys Glu Ile Glu Phe Gly Thr Ser Leu Asp Glu Glu Ile Ile Leu
         115                 120                 125            
 Lys Ala Pro Ile Ala Ala Pro Glu Pro Glu Leu Lys Thr Asp Pro Ser
     130                 135                 140                
 Leu Asp Leu His Ser Leu Ser Ser Ala Glu Thr Gln Pro Ala Gln Glu
 145                 150                 155                 160
 Glu Leu Arg Glu Asp Pro Asp Phe Glu Ile Lys Glu Gly Glu Gly Leu
                 165                 170                 175    
 Glu Glu Cys Ser Lys Ile Glu Val Lys Glu Glu Ser Pro Gln Ser Lys
             180                 185                 190        
 Ala Glu Thr Glu Leu Lys Ala Ser Gln Lys Pro Ile Arg Lys His Arg
         195                 200                 205            
 Asn Met His Cys Lys Val Ser Leu Leu Asp Asp Thr Val Tyr Glu Cys
     210                 215                 220                
 Val Val Glu Lys His Ala Lys Gly Gln Asp Leu Leu Lys Arg Val Cys
 225                 230                 235                 240
 Glu His Leu Asn Leu Leu Glu Glu Asp Tyr Phe Gly Leu Ala Ile Trp
                 245                 250                 255    
 Asp Asn Ala Thr Ser Lys Thr Trp Leu Asp Ser Ala Lys Glu Ile Lys
             260                 265                 270        
 Lys Gln Val Arg Gly Val Pro Trp Asn Phe Thr Phe Asn Val Lys Phe
         275                 280                 285            
 Tyr Pro Pro Asp Pro Ala Gln Leu Thr Glu Asp Ile Thr Arg Tyr Tyr
     290                 295                 300                
 Leu Cys Leu Gln Leu Arg Gln Asp Ile Val Ala Gly Arg Leu Pro Cys
 305                 310                 315                 320
 Ser Phe Ala Thr Leu Ala Leu Leu Gly Ser Tyr Thr Ile Gln Ser Glu
                 325                 330                 335    
 Leu Gly Asp Tyr Asp Pro Glu Leu His Gly Val Asp Tyr Val Ser Asp
             340                 345                 350        
 Phe Lys Leu Ala Pro Asn Gln Thr Lys Glu Leu Glu Glu Lys Val Met
         355                 360                 365            
 Glu Leu His Lys Ser Tyr Arg Ser Met Thr Pro Ala Gln Ala Asp Leu
     370                 375                 380                
 Glu Phe Leu Glu Asn Ala Lys Lys Leu Ser Met Tyr Gly Val Asp Leu
 385                 390                 395                 400
 His Lys Ala Lys Asp Leu Glu Gly Val Asp Ile Ile Leu Gly Val Cys
                 405                 410                 415    
 Ser Ser Gly Leu Leu Val Tyr Lys Asp Lys Leu Arg Ile Asn Arg Phe
             420                 425                 430        
 Pro Trp Pro Lys Val Leu Lys Ile Ser Tyr Lys Arg Ser Ser Phe Phe
         435                 440                 445            
 Ile Lys Ile Arg Pro Gly Glu Gln Glu Gln Tyr Glu Ser Thr Ile Gly
     450                 455                 460                
 Phe Lys Leu Pro Ser Tyr Arg Ala Ala Lys Lys Leu Trp Lys Val Cys
 465                 470                 475                 480
 Val Glu His His Thr Phe Phe Arg Leu Thr Ser Thr Asp Thr Ile Pro
                 485                 490                 495    
 Lys Ser Lys Phe Leu Ala Leu Gly Ser Lys Phe Arg Tyr Ser Gly Arg
             500                 505                 510        
 Thr Gln Ala Gln Thr Arg Gln Ala Ser Ala Leu Ile Asp Arg Pro Ala
         515                 520                 525            
 Pro His Phe Glu Arg Thr Ala Ser Lys Arg Ala Ser Arg Ser Leu Asp
     530                 535                 540                
 Gly Ala Ala Ala Val Asp Ser Ala Asp Arg Ser Pro Arg Pro Thr Ser
 545                 550                 555                 560
 Ala Pro Ala Ile Thr Gln Gly Gln Val Ala Glu Gly Gly Val Leu Asp
                 565                 570                 575    
 Ala Ser Ala Lys Lys Thr Val Val Pro Lys Ala Gln Lys Glu Thr Val
             580                 585                 590        
 Lys Ala Glu Val Lys Lys Glu Asp Glu Pro Pro Glu Gln Ala Glu Pro
         595                 600                 605            
 Glu Pro Thr Glu Ala Trp Lys Lys Lys Arg Glu Arg Leu Asp Gly Glu
     610                 615                 620                
 Asn Ile Tyr Ile Arg His Ser Asn Leu Met Leu Glu Asp Leu Asp Lys
 625                 630                 635                 640
 Ser Gln Glu Glu Ile Lys Lys His His Ala Ser Ile Ser Glu Leu Lys
                 645                 650                 655    
 Lys Asn Phe Met Glu Ser Val Pro Glu Pro Arg Pro Ser Glu Trp Asp
             660                 665                 670        
 Lys Arg Leu Ser Thr His Ser Pro Phe Arg Thr Leu Asn Ile Asn Gly
         675                 680                 685            
 Gln Ile Pro Thr Gly Glu Gly Pro Pro Leu Val Lys Thr Gln Thr Val
     690                 695                 700                
 Thr Ile Ser Asp Asn Ala Asn Ala Val Lys Ser Glu Ile Pro Thr Lys
 705                 710                 715                 720
 Asp Val Pro Ile Val His Thr Glu Thr Lys Thr Ile Thr Tyr Glu Ala
                 725                 730                 735    
 Ala Gln Thr Val Lys Gly Gly Ile Ser Glu Thr Arg Ile Glu Lys Arg
             740                 745                 750        
 Ile Val Ile Thr Gly Asp Ala Asp Ile Asp His Asp Gln Val Leu Val
         755                 760                 765            
 Gln Ala Ile Lys Glu Ala Lys Glu Gln His Pro Asp Met Ser Val Thr
     770                 775                 780                
 Lys Val Val Val His Gln Glu Thr Glu Ile Ala Asp Glu
 785                 790                 795        



      <210> 921
      <211> 485
      <212> PRT
      <213> Homo sapiens


      <400> 921
 Met Pro Ala Ser Ser Leu Glu Ser Cys Leu Met Pro Glu Tyr Phe Glu
   1               5                  10                  15    
 Pro Gln Ile Lys Asp Ile Ser Glu Ala Ala Leu Lys Glu Arg Ile Glu
              20                  25                  30        
 Leu Arg Lys Val Lys Ala Ser Val Asp Met Phe Asp Gln Leu Leu Gln
          35                  40                  45            
 Ala Ala Pro Ala Leu Glu Ala Ala Gly Tyr Arg Ala Asn Thr Asp Leu
      50                  55                  60                
 Cys Asn Ala Asn Gln Ala Cys Ile Ala Leu Arg Gln Pro His Pro Arg
  65                  70                  75                  80
 Pro Trp Phe Ile Asn Lys Asp Lys Ile Tyr Ser Cys Lys Lys Ser Cys
                  85                  90                  95    
 Gln Glu Glu Glu Asn Asp Glu Thr Ser Arg Arg Lys Ala Gly His Gln
             100                 105                 110        
 Phe Gly Val Thr Trp Arg Ala Lys Asn Asn Ala Glu Arg Ile Phe Ser
         115                 120                 125            
 Leu Met Pro Glu Lys Asn Glu His Ser Tyr Cys Thr Met Ile Arg Gly
     130                 135                 140                
 Met Val Lys His Arg Ala Tyr Glu Gln Ala Leu Asn Leu Tyr Thr Glu
 145                 150                 155                 160
 Leu Leu Asn Asn Arg Leu His Ala Asp Val Tyr Thr Phe Asn Ala Leu
                 165                 170                 175    
 Ile Glu Ala Thr Val Cys Ala Ile Asn Glu Lys Phe Glu Glu Lys Trp
             180                 185                 190        
 Ser Lys Ile Leu Glu Leu Leu Arg His Met Val Ala Gln Lys Val Lys
         195                 200                 205            
 Pro Asn Leu Gln Thr Phe Asn Thr Ile Leu Lys Cys Leu Arg Arg Phe
     210                 215                 220                
 His Val Phe Ala Arg Ser Pro Ala Leu Gln Val Leu Arg Glu Met Lys
 225                 230                 235                 240
 Ala Ile Gly Ile Ala Met Cys Leu Val Ala Thr Met Cys Arg Asp Ala
                 245                 250                 255    
 Asp Ser Glu His Phe His Leu Cys Gln Lys Phe Val Asp Val Ser Ala
             260                 265                 270        
 Pro Glu Glu Ser Ser Lys Phe Phe Asp Leu Ile Cys Leu Met Glu Gln
         275                 280                 285            
 Ile Asp Val Thr Leu Lys Trp Tyr Glu Asp Leu Ile Pro Ser Ala Tyr
     290                 295                 300                
 Phe Pro His Ser Gln Thr Met Ile His Leu Leu Gln Ala Leu Asp Val
 305                 310                 315                 320
 Ala Asn Arg Leu Glu Val Ile Pro Lys Ile Trp Lys Asp Ser Lys Glu
                 325                 330                 335    
 Tyr Gly His Thr Phe Arg Ser Asp Leu Arg Glu Glu Ile Leu Met Leu
             340                 345                 350        
 Met Ala Arg Asp Lys His Pro Pro Glu Gly Trp Glu Asn Ser Gly Ser
         355                 360                 365            
 Leu Val Ser Thr Val Pro Gln Val Tyr Thr Leu Glu Ala Phe Val Phe
     370                 375                 380                
 Glu Ser Lys Thr Leu Ala His Ala Gly Arg Gly Ser Phe Ile Trp Pro
 385                 390                 395                 400
 His Asn Thr Ser Glu Leu Leu Asn Glu Leu Met Asp Ser Ala Lys Val
                 405                 410                 415    
 Ser Asn Ser Pro Ser Gln Ala Ile Glu Val Val Glu Leu Ala Ser Ala
             420                 425                 430        
 Phe Ser Leu Pro Ile Cys Glu Gly Leu Thr Gln Arg Val Met Ser Asp
         435                 440                 445            
 Phe Ala Ile Asn Gln Glu Gln Lys Glu Ala Leu Ser Asn Leu Thr Ala
     450                 455                 460                
 Leu Thr Ser Asp Ser Asp Thr Asp Ser Ser Ser Asp Ser Asp Ser Asp
 465                 470                 475                 480
 Thr Ser Glu Gly Lys
                 485



      <210> 922
      <211> 299
      <212> PRT
      <213> Homo sapiens


      <400> 922
 Met Arg Gln Gly Asp Val Ala Gly Ser Pro Ala Ser Ser Ser Arg Ser
   1               5                  10                  15    
 Gly Leu Ser Lys Arg Leu Gln Ser Ala Thr Ile Thr Val Arg Thr Pro
              20                  25                  30        
 Arg Thr His Leu Glu Gly Ile Val Glu Pro Gln His Arg Ala Gly Gly
          35                  40                  45            
 Asp Ile Ser Asp Ala Val Gln Val Pro Arg Asp Glu Ala Gly Leu Val
      50                  55                  60                
 Gln Ser Leu Glu Gln Asp Ala Asn Trp Tyr Pro Glu Trp Glu Lys Leu
  65                  70                  75                  80
 Arg Cys Arg Thr Trp Ser Val Cys Ser Arg Ser Val Cys Thr Ser Thr
                  85                  90                  95    
 Gln Gly Thr Val Ser Tyr Ser Arg Trp Asn Ser Ser Tyr Gln Asp Met
             100                 105                 110        
 Ala Ala Ala Ala Gly Ser Leu Gly Gln Lys Pro Gln Arg Pro Arg Arg
         115                 120                 125            
 Pro Ala Ser Pro Ile Ser Thr Ile Gln Pro Lys Ala Asn Phe Asp Ala
     130                 135                 140                
 Gln Gln Phe Ala Gly Thr Trp Leu Leu Val Ala Val Gly Ser Ala Cys
 145                 150                 155                 160
 Arg Phe Leu Gln Glu Gln Gly His Arg Ala Glu Ala Thr Thr Leu His
                 165                 170                 175    
 Val Ala Pro Gln Gly Thr Ala Met Ala Val Ser Thr Phe Arg Lys Leu
             180                 185                 190        
 Asp Gly Ile Cys Trp Gln Val Arg Gln Leu Tyr Gly Asp Thr Gly Val
         195                 200                 205            
 Leu Gly Arg Phe Leu Leu Gln Ala Arg Asp Ala Arg Gly Ala Val His
     210                 215                 220                
 Val Val Val Ala Glu Thr Asp Tyr Gln Ser Phe Ala Val Leu Tyr Leu
 225                 230                 235                 240
 Glu Arg Ala Gly Gln Leu Ser Val Lys Leu Tyr Ala Arg Ser Leu Pro
                 245                 250                 255    
 Val Ser Asp Ser Val Leu Ser Gly Phe Glu Gln Arg Val Gln Glu Ala
             260                 265                 270        
 His Leu Thr Glu Asp Gln Ile Phe Tyr Phe Pro Lys Tyr Gly Phe Cys
         275                 280                 285            
 Glu Ala Ala Asp Gln Phe His Val Leu Asp Lys
     290                 295                



      <210> 923
      <211> 543
      <212> PRT
      <213> Homo sapiens


      <400> 923
 Met Ser Arg Gln Leu Asn Ile Lys Ser Ser Gly Asp Lys Gly Asn Phe
   1               5                  10                  15    
 Ser Val His Ser Ala Val Val Pro Arg Lys Ala Val Gly Ser Leu Ala
              20                  25                  30        
 Ser Tyr Cys Ala Ala Gly Arg Gly Ala Gly Ala Gly Phe Gly Ser Arg
          35                  40                  45            
 Ser Leu Tyr Ser Leu Gly Gly Asn Arg Arg Ile Ser Phe Asn Val Ala
      50                  55                  60                
 Gly Gly Gly Val Arg Ala Gly Gly Tyr Gly Phe Arg Pro Gly Ser Gly
  65                  70                  75                  80
 Tyr Gly Gly Gly Arg Ala Ser Gly Phe Ala Gly Ser Met Phe Gly Ser
                  85                  90                  95    
 Val Ala Leu Gly Pro Ala Cys Leu Ser Val Cys Pro Pro Gly Gly Ile
             100                 105                 110        
 His Gln Val Thr Val Asn Lys Ser Leu Leu Ala Pro Leu Asn Val Glu
         115                 120                 125            
 Leu Asp Pro Glu Ile Gln Lys Val Arg Ala Gln Glu Arg Glu Gln Ile
     130                 135                 140                
 Lys Val Leu Asn Asp Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe
 145                 150                 155                 160
 Leu Glu Gln Gln Asn Gln Val Leu Glu Thr Lys Trp Glu Leu Leu Gln
                 165                 170                 175    
 Gln Leu Asp Leu Asn Asn Cys Lys Lys Asn Leu Glu Pro Ile Leu Glu
             180                 185                 190        
 Gly Tyr Ile Ser Asn Leu Arg Lys Gln Leu Glu Thr Leu Ser Gly Asp
         195                 200                 205            
 Arg Val Arg Leu Asp Ser Glu Leu Arg Ser Met Arg Asp Leu Val Glu
     210                 215                 220                
 Asp Tyr Lys Lys Arg Tyr Glu Val Glu Ile Asn Arg Arg Thr Thr Ala
 225                 230                 235                 240
 Glu Asn Glu Phe Val Val Leu Lys Lys Asp Ala Asp Ala Ala Tyr Ala
                 245                 250                 255    
 Val Lys Val Glu Leu Gln Ala Lys Val Asp Ser Leu Asp Lys Asp Ile
             260                 265                 270        
 Lys Phe Leu Lys Cys Leu Tyr Asp Ala Glu Ile Ala Gln Ile Gln Thr
         275                 280                 285            
 His Ala Ser Glu Thr Ser Val Ile Leu Ser Met Asp Asn Asn Arg Asp
     290                 295                 300                
 Leu Asp Leu Asp Ser Ile Ile Ala Glu Val Arg Met His Tyr Glu Glu
 305                 310                 315                 320
 Ile Ala Leu Lys Ser Lys Ala Glu Ala Glu Ala Leu Tyr Gln Thr Lys
                 325                 330                 335    
 Cys Pro Cys Leu Ile Thr Asn Phe Leu Ser Leu Gly Asn Gln Ile Gln
             340                 345                 350        
 Glu Leu Gln Leu Ala Ala Ser Arg His Gly Asp Asp Leu Lys His Thr
         355                 360                 365            
 Arg Ser Glu Met Val Glu Leu Asn Arg Leu Ile Gln Arg Ile Arg Cys
     370                 375                 380                
 Glu Ile Gly Asn Val Lys Lys Gln Arg Ala Ser Leu Glu Thr Ala Ile
 385                 390                 395                 400
 Ala Asp Ala Glu Gln Arg Gly Asp Asn Ala Leu Lys Asp Ala Gln Ala
                 405                 410                 415    
 Lys Leu Asp Glu Leu Glu Gly Ala Leu His Gln Ala Lys Glu Glu Leu
             420                 425                 430        
 Ala Arg Met Leu Arg Glu Tyr Gln Glu Leu Met Ser Leu Lys Leu Ala
         435                 440                 445            
 Leu Asp Met Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu
     450                 455                 460                
 Cys Arg Met Ser Gly Glu Asn Pro Ser Ser Val Ser Ile Ser Val Ile
 465                 470                 475                 480
 Ser Ser Ser Ser Tyr Ser Tyr His His Pro Ser Ser Ala Gly Val Asp
                 485                 490                 495    
 Leu Gly Ala Ser Ala Val Ala Gly Ser Ser Gly Ser Thr Gln Ser Gly
             500                 505                 510        
 Gln Thr Lys Thr Thr Glu Ala Arg Gly Gly Asp Leu Lys Asp Thr Gln
         515                 520                 525            
 Gly Lys Ser Thr Pro Ala Ser Ile Pro Ala Arg Lys Ala Thr Arg
     530                 535                 540            



      <210> 924
      <211> 279
      <212> PRT
      <213> Homo sapiens


      <400> 924
 Met Ser Ser Tyr Phe Val Asn Ser Leu Phe Ser Lys Tyr Lys Thr Gly
   1               5                  10                  15    
 Glu Ser Leu Arg Pro Asn Tyr Tyr Asp Cys Gly Phe Ala Gln Asp Leu
              20                  25                  30        
 Gly Gly Arg Pro Thr Val Val Tyr Gly Pro Ser Ser Gly Gly Ser Phe
          35                  40                  45            
 Gln His Pro Ser Gln Ile Gln Glu Phe Tyr His Gly Pro Ser Ser Leu
      50                  55                  60                
 Ser Thr Ala Pro Tyr Gln Gln Asn Pro Cys Ala Val Ala Cys His Gly
  65                  70                  75                  80
 Asp Pro Gly Asn Phe Tyr Gly Tyr Asp Pro Leu Gln Arg Gln Ser Leu
                  85                  90                  95    
 Phe Gly Ala Gln Asp Pro Asp Leu Val Gln Tyr Ala Asp Cys Lys Leu
             100                 105                 110        
 Ala Ala Ala Ser Gly Leu Gly Glu Glu Ala Glu Gly Ser Glu Gln Ser
         115                 120                 125            
 Pro Ser Pro Thr Gln Leu Phe Pro Trp Met Arg Pro Gln Ala Ala Ala
     130                 135                 140                
 Gly Arg Arg Arg Gly Arg Gln Thr Tyr Ser Arg Tyr Gln Thr Leu Glu
 145                 150                 155                 160
 Leu Glu Lys Glu Phe Leu Phe Asn Pro Tyr Leu Thr Arg Lys Arg Arg
                 165                 170                 175    
 Ile Glu Val Ser His Ala Leu Gly Leu Thr Glu Arg Gln Val Lys Ile
             180                 185                 190        
 Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Asn Asn Lys Asp
         195                 200                 205            
 Lys Phe Pro Ser Ser Lys Cys Glu Gln Glu Glu Leu Glu Lys Gln Lys
     210                 215                 220                
 Leu Glu Arg Ala Pro Glu Ala Ala Asp Glu Gly Asp Ala Gln Lys Gly
 225                 230                 235                 240
 Asp Lys Lys Asn Gly Ser Val Gln Gly Pro Trp Ala Gly Ser Cys Ala
                 245                 250                 255    
 Leu Gly Ala Pro Arg Lys Thr Cys Ser Ile Ser Ala Arg Ile Ser Gly
             260                 265                 270        
 Ala Pro Arg Glu Thr Glu Ser
         275                



      <210> 925
      <211> 343
      <212> PRT
      <213> Homo sapiens


      <400> 925
 Met Leu Val Leu His Asn Ser Gln Lys Leu Gln Ile Leu Tyr Lys Ser
   1               5                  10                  15    
 Leu Glu Lys Ser Ile Pro Glu Ser Ile Lys Val Tyr Gly Ala Ile Phe
              20                  25                  30        
 Asn Ile Lys Asp Lys Asn Pro Phe Asn Met Glu Val Leu Val Asp Ala
          35                  40                  45            
 Trp Pro Asp Tyr Gln Ile Val Ile Thr Arg Pro Gln Lys Gln Val Gly
      50                  55                  60                
 Ala Ile Val Thr Glu Tyr Glu Gly Ser His Ser Pro Asp Val Leu Cys
  65                  70                  75                  80
 Met Ala Met Arg Glu Leu Lys Leu Arg Ser Gly Glu Lys Asn Ile Asp
                  85                  90                  95    
 Thr Val Asp Val Cys Arg Phe Trp Lys Gly Cys Leu Gly Asp Arg Glu
             100                 105                 110        
 Met Lys Asp Asp Gln Asp His Tyr Thr Asn Thr Tyr His Ile Phe Thr
         115                 120                 125            
 Lys Ala Pro Asp Lys Leu Glu Glu Val Leu Ser Tyr Ser Asn Val Ile
     130                 135                 140                
 Ser Trp Glu Gln Thr Leu Gln Ile Gln Gly Cys Gln Glu Gly Leu Asp
 145                 150                 155                 160
 Glu Ala Ile Arg Lys Val Ala Thr Ser Lys Ser Val Gln Val Asp Tyr
                 165                 170                 175    
 Met Lys Thr Ile Leu Phe Ile Pro Glu Leu Pro Lys Lys His Lys Thr
             180                 185                 190        
 Ser Ser Asn Asp Lys Met Glu Leu Phe Glu Val Asp Asp Asp Asn Lys
         195                 200                 205            
 Glu Gly Asn Phe Ser Asn Met Phe Leu Asp Ala Ser His Ala Gly Leu
     210                 215                 220                
 Val Asn Glu His Trp Ala Phe Gly Lys Asn Glu Arg Ser Leu Lys Tyr
 225                 230                 235                 240
 Ile Glu Arg Cys Leu Gln Asp Phe Leu Gly Phe Gly Val Leu Gly Pro
                 245                 250                 255    
 Glu Gly Gln Leu Val Ser Trp Ile Val Met Glu Gln Ser Cys Glu Leu
             260                 265                 270        
 Arg Met Gly Tyr Thr Val Pro Lys Tyr Arg His Gln Gly Asn Met Leu
         275                 280                 285            
 Gln Ile Gly Tyr His Leu Glu Lys Tyr Leu Ser Gln Lys Glu Ile Pro
     290                 295                 300                
 Phe Tyr Phe His Val Ala Asp Asn Asn Glu Lys Ser Leu Gln Ala Leu
 305                 310                 315                 320
 Asn Asn Leu Gly Phe Lys Ile Cys Pro Cys Gly Trp His Gln Trp Lys
                 325                 330                 335    
 Cys Thr Pro Lys Lys Tyr Cys
             340            



      <210> 926
      <211> 432
      <212> PRT
      <213> Homo sapiens


      <400> 926
 Met Lys Asp Gln His Leu Arg Gly Phe Phe Ser Asp Ser Thr Ser Phe
   1               5                  10                  15    
 Asn Ile Leu Met Asp Met Leu Phe Ile Lys Gly Lys Tyr Lys Ser Ala
              20                  25                  30        
 Leu Gln Val Leu Ile Glu Met Lys Asn Leu Asp Val Lys Phe Thr Lys
          35                  40                  45            
 Asp Thr Tyr Val Leu Ala Phe Ala Ile Cys Tyr Lys Leu Asn Ser Pro
      50                  55                  60                
 Glu Ser Phe Lys Ile Cys Thr Thr Leu Arg Glu Glu Ala Leu Leu Lys
  65                  70                  75                  80
 Gly Glu Ile Leu Ser Arg Arg Ala Ser Cys Phe Ala Val Ala Leu Ala
                  85                  90                  95    
 Leu Asn Gln Asn Glu Met Ala Lys Ala Val Ser Ile Phe Ser Gln Ile
             100                 105                 110        
 Met Asn Pro Glu Ser Ile Ala Cys Ile Asn Leu Asn Ile Ile Ile His
         115                 120                 125            
 Ile Gln Ser Asn Met Leu Glu Asn Leu Ile Lys Thr Leu Lys Asn Ala
     130                 135                 140                
 Ala Glu Gly Asn Leu Ser Lys Phe Val Lys Arg His Val Phe Ser Glu
 145                 150                 155                 160
 Glu Val Leu Ala Lys Val Arg Glu Lys Val Lys Asp Val Pro Ala Leu
                 165                 170                 175    
 Val Ala Lys Phe Asp Glu Ile Tyr Gly Thr Leu His Ile Thr Gly Gln
             180                 185                 190        
 Val Thr Thr Asp Ser Leu Asp Ala Val Leu Cys His Thr Pro Arg Asp
         195                 200                 205            
 Arg Lys Ser His Thr Leu Leu Leu Asn Lys Arg Met Ser Thr Tyr Gly
     210                 215                 220                
 Ser Glu Gly Pro Ala Ser Ser Glu Leu Leu Pro Phe Leu Arg Ser Gln
 225                 230                 235                 240
 Val Ser His Phe Ser Arg Gln Cys Ala Asp Thr Trp Ser Ser Pro Glu
                 245                 250                 255    
 Ile Pro Lys Phe Thr Glu Trp Leu Arg Lys Arg Ser Met Gln Glu Arg
             260                 265                 270        
 Pro Asn Leu Asn Cys Arg Leu Cys Pro Lys Thr Arg Ala Gln Glu Glu
         275                 280                 285            
 Glu Arg Thr Asp Ala Leu Val Gln Asp Asp Phe Phe Met Gly Ile Asp
     290                 295                 300                
 Arg Tyr Ile Leu Glu Asn His Pro Lys Tyr Leu Glu Glu Thr Leu Val
 305                 310                 315                 320
 Gln Leu Cys Ile Val Gln Gln Leu Met Arg Lys Val Thr Arg Thr Leu
                 325                 330                 335    
 Gly Ala Val His Leu Leu Pro Lys Cys Val Ser Gln Cys Pro Ala Ser
             340                 345                 350        
 Tyr Ala Ala Phe Asp Met Ser Lys Val Pro Gln Gly Val Ser Pro Ser
         355                 360                 365            
 Leu Asn Ile Arg Phe Leu Ile Tyr Thr Pro Asn Ser Leu Tyr Thr Ser
     370                 375                 380                
 Gly Ser Cys Pro Ser Leu Asn Lys Ala Gly Lys Phe Pro Ser Leu Phe
 385                 390                 395                 400
 Met His Asn Glu Asn Ile Val Ala Arg Val Asp Glu Val Lys Ser Thr
                 405                 410                 415    
 Ile Asn Phe Leu Thr Glu Val Leu Cys Leu Ala Met Thr Asn Ala Met
             420                 425                 430        





      <210> 927
      <211> 236
      <212> PRT
      <213> Homo sapiens


      <400> 927
 Met Asp Lys Glu Asp Lys Ser Leu Ala Leu Val Thr Gly Arg Ile Lys
   1               5                  10                  15    
 Lys Ser Gly Lys Asn Asp Cys Gly Gly Ala Pro Glu Pro Leu Thr Gly
              20                  25                  30        
 Leu Ser Ala Ala Ala Asn Ala Arg Arg Ser Pro Asp Ala Arg Ile Arg
          35                  40                  45            
 Pro Gly Leu Pro Asp Pro Leu Arg Ala Leu Glu Asp Pro Gly Leu Glu
      50                  55                  60                
 Gly Ala Ala Leu Ala Arg Leu Ala Pro Arg Leu Pro Glu Lys Gln Leu
  65                  70                  75                  80
 Cys Pro Pro Phe Gly Cys Ala His Leu Leu Ser Ala Ser Val Met Ala
                  85                  90                  95    
 Ala Ala Val Ala Ala Ala Gly Ala Gly Glu Pro Gln Ser Pro Asp Glu
             100                 105                 110        
 Leu Leu Pro Lys Gly Asp Ala Glu Lys Pro Glu Glu Glu Leu Glu Glu
         115                 120                 125            
 Asp Asp Asp Glu Glu Leu Asp Glu Thr Leu Ser Glu Arg Leu Trp Gly
     130                 135                 140                
 Leu Thr Glu Met Phe Pro Glu Arg Val Arg Ser Ala Ala Gly Ala Thr
 145                 150                 155                 160
 Phe Asp Leu Ser Leu Phe Val Ala Gln Lys Met Tyr Arg Phe Ser Arg
                 165                 170                 175    
 Ala Ala Leu Trp Ile Gly Thr Thr Ser Phe Met Ile Leu Val Leu Pro
             180                 185                 190        
 Val Val Phe Glu Thr Glu Lys Leu Gln Met Glu Gln Gln Gln Gln Leu
         195                 200                 205            
 Gln Gln Arg Gln Ile Leu Leu Gly Pro Asn Thr Gly Leu Ser Gly Gly
     210                 215                 220                
 Met Pro Gly Ala Leu Pro Ser Leu Pro Gly Lys Ile
 225                 230                 235    



      <210> 928
      <211> 428
      <212> PRT
      <213> Homo sapiens


      <400> 928
 Met Ala Ser Asn Asp Lys Gly Met Ala Pro Ser Leu Gly Ser Pro Trp
   1               5                  10                  15    
 Ala Ser Gln Met Gly Pro Trp Asp Ala Ile Leu Lys Ala Val Lys Asp
              20                  25                  30        
 Gln Leu Pro Ser Leu Asp Ser Asp Ser Pro Leu Asp Arg Ala Arg Thr
          35                  40                  45            
 Pro Thr Glu Asn Ala Gln Phe Gln Cys Ile Val Ile Ser Leu Arg Gly
      50                  55                  60                
 Ile Leu His Leu Trp Phe Gly Val Pro Glu Met Ala Leu Lys Asp Ala
  65                  70                  75                  80
 Gln Thr Asn Ser Pro Ser Pro Leu Ile Cys Pro Gln Ser Asp Tyr Gly
                  85                  90                  95    
 Glu Glu Glu Leu Phe Ile Phe Gln Arg Asn Gln Thr Ser Leu Ile Pro
             100                 105                 110        
 Asp Leu Ser Glu Glu Leu Ala Glu Asp Pro Ala Asp Gly Asp Lys Ser
         115                 120                 125            
 Arg Ala Trp Val Ala Ala Ala Glu Glu Ser Leu Pro Glu Pro Val Leu
     130                 135                 140                
 Val Pro Ala Glu Leu Ala Thr Glu Pro Gly Cys Arg Gln Asn Thr Arg
 145                 150                 155                 160
 Thr Lys Asp Ala Ser Ser Gln Glu Gly Arg Asp Pro Gly Arg Pro Phe
                 165                 170                 175    
 Glu Ser Ser Gly Glu Val Ser Ala Leu Leu Gly Met Ala Glu Glu Pro
             180                 185                 190        
 Pro Arg Trp Leu Glu Gly Asp Leu Gly Ser Leu Ser Phe Asn Thr Lys
         195                 200                 205            
 Gly Ser Gln Gly Pro Pro Trp Asp Pro Gln Ala Glu Ala Thr Leu Ser
     210                 215                 220                
 Cys His Glu Gly Asp Pro Lys Ala Glu Pro Leu Ser Thr Ala Ser Gln
 225                 230                 235                 240
 Glu Ser Val Asn Arg Arg Ala Leu Arg Gln Glu Arg Arg Lys Met Ile
                 245                 250                 255    
 Glu Thr Asp Ile Leu Gln Lys Val Thr Arg Asp Ala Cys Gly Pro Thr
             260                 265                 270        
 Ser Ser Asp Lys Gly Gly Val Lys Glu Ala Pro Cys His Ala Ala Glu
         275                 280                 285            
 Ser Ala Pro Arg Ser Lys Met Pro Leu Val Glu Pro Pro Glu Gly Pro
     290                 295                 300                
 Pro Val Leu Ser Leu Gln Gln Leu Glu Ala Trp Asp Leu Asp Asp Ile
 305                 310                 315                 320
 Leu Gln Ser Leu Ala Gly Gln Glu Asp Asn Gln Gly Asn Arg Ala Pro
                 325                 330                 335    
 Gly Thr Val Trp Trp Ala Ala Asp His Arg Gln Val Gln Asp Cys Met
             340                 345                 350        
 Val Pro Ser Ala His Asn Arg Leu Met Glu Gln Leu Ala Leu Leu Cys
         355                 360                 365            
 Thr Thr Gln Ser Lys Ala Ser Ala Cys Ala Arg Lys Val Pro Ala Asp
     370                 375                 380                
 Thr Pro Gln Asp Thr Lys Glu Ala Asp Ser Gly Ser Arg Cys Ala Ser
 385                 390                 395                 400
 Arg Lys Arg Gly Ser Gln Ala Gly Pro Gly Pro Gln Leu Ala Gln Gly
                 405                 410                 415    
 Met Arg Leu Asn Ala Gly Val Pro His His Leu Tyr
             420                 425            



      <210> 929
      <211> 766
      <212> PRT
      <213> Homo sapiens


      <400> 929
 Met Ala Ala Asp Pro Thr Glu Leu Arg Leu Gly Ser Leu Pro Val Phe
   1               5                  10                  15    
 Thr Arg Asp Asp Phe Glu Gly Asp Trp Arg Leu Val Ala Ser Gly Gly
              20                  25                  30        
 Phe Ser Gln Val Phe Gln Ala Arg His Arg Arg Trp Arg Thr Glu Tyr
          35                  40                  45            
 Ala Ile Lys Cys Ala Pro Cys Leu Pro Pro Asp Ala Ala Ser Ser Asp
      50                  55                  60                
 Val Asn Tyr Leu Ile Glu Glu Ala Ala Lys Met Lys Lys Ile Lys Phe
  65                  70                  75                  80
 Gln His Ile Val Ser Ile Tyr Gly Val Cys Lys Gln Pro Leu Gly Ile
                  85                  90                  95    
 Val Met Glu Phe Met Ala Asn Gly Ser Leu Glu Lys Val Leu Ser Thr
             100                 105                 110        
 His Ser Leu Cys Trp Lys Leu Arg Phe Arg Ile Ile His Glu Thr Ser
         115                 120                 125            
 Leu Ala Met Asn Phe Leu His Ser Ile Lys Pro Pro Leu Leu His Leu
     130                 135                 140                
 Asp Leu Lys Pro Gly Asn Ile Leu Leu Asp Ser Asn Met His Val Lys
 145                 150                 155                 160
 Ile Ser Asp Phe Gly Leu Ser Lys Trp Met Glu Gln Ser Thr Arg Met
                 165                 170                 175    
 Gln Tyr Ile Glu Arg Ser Ala Leu Arg Gly Met Leu Ser Tyr Ile Pro
             180                 185                 190        
 Pro Glu Met Phe Leu Glu Ser Asn Lys Ala Pro Gly Pro Lys Tyr Asp
         195                 200                 205            
 Val Tyr Ser Phe Ala Ile Val Ile Trp Glu Leu Leu Thr Gln Lys Lys
     210                 215                 220                
 Pro Tyr Ser Gly Phe Asn Met Met Met Ile Ile Ile Arg Val Ala Ala
 225                 230                 235                 240
 Gly Met Arg Pro Ser Leu Gln Pro Val Ser Asp Gln Trp Pro Ser Glu
                 245                 250                 255    
 Ala Gln Gln Met Val Asp Leu Met Lys Arg Cys Trp Asp Gln Asp Pro
             260                 265                 270        
 Lys Lys Arg Pro Cys Phe Leu Asp Ile Thr Ile Glu Thr Asp Ile Leu
         275                 280                 285            
 Leu Ser Leu Leu Gln Ser Arg Val Ala Val Pro Glu Ser Lys Ala Leu
     290                 295                 300                
 Ala Arg Lys Val Ser Cys Lys Leu Ser Leu Arg Gln Pro Gly Glu Val
 305                 310                 315                 320
 Asn Glu Asp Ile Ser Gln Glu Leu Met Asp Ser Ala Asp Ser Gly Asn
                 325                 330                 335    
 Tyr Leu Lys Arg Ala Leu Gln Leu Ser Asp Arg Lys Asn Leu Val Pro
             340                 345                 350        
 Arg Asp Glu Glu Leu Cys Ile Tyr Glu Asn Lys Val Thr Pro Leu His
         355                 360                 365            
 Phe Leu Val Ala Gln Gly Ser Val Glu Gln Val Arg Leu Leu Leu Ala
     370                 375                 380                
 His Glu Val Asp Val Asp Cys Gln Thr Ala Ser Gly Tyr Thr Pro Leu
 385                 390                 395                 400
 Leu Ile Ala Ala Gln Asp Gln Gln Pro Asp Leu Cys Ala Leu Leu Leu
                 405                 410                 415    
 Ala His Gly Ala Asp Ala Asn Arg Val Asp Glu Asp Gly Trp Ala Pro
             420                 425                 430        
 Leu His Phe Ala Ala Gln Asn Gly Asp Asp Gly Thr Ala Arg Leu Leu
         435                 440                 445            
 Leu Asp His Gly Ala Cys Val Asp Ala Gln Glu Arg Glu Gly Trp Thr
     450                 455                 460                
 Pro Leu His Leu Ala Ala Gln Asn Asn Phe Glu Asn Val Ala Arg Leu
 465                 470                 475                 480
 Leu Val Ser Arg Gln Ala Asp Pro Asn Leu His Glu Ala Glu Gly Lys
                 485                 490                 495    
 Thr Pro Leu His Val Ala Ala Tyr Phe Gly His Val Ser Leu Val Lys
             500                 505                 510        
 Leu Leu Thr Ser Gln Gly Ala Glu Leu Asp Ala Gln Gln Arg Asn Leu
         515                 520                 525            
 Arg Thr Pro Leu His Leu Ala Val Glu Arg Gly Lys Val Arg Ala Ile
     530                 535                 540                
 Gln His Leu Leu Lys Ser Gly Ala Val Pro Asp Ala Leu Asp Gln Ser
 545                 550                 555                 560
 Gly Tyr Gly Pro Leu His Thr Ala Ala Ala Arg Gly Lys Tyr Leu Ile
                 565                 570                 575    
 Cys Lys Met Leu Leu Arg Tyr Gly Ala Ser Leu Glu Leu Pro Thr His
             580                 585                 590        
 Gln Gly Trp Thr Pro Leu His Leu Ala Ala Tyr Lys Gly His Leu Glu
         595                 600                 605            
 Ile Ile His Leu Leu Ala Glu Ser His Ala Asn Met Gly Ala Leu Gly
     610                 615                 620                
 Ala Val Asn Trp Thr Pro Leu His Leu Ala Ala Arg His Gly Glu Glu
 625                 630                 635                 640
 Ala Val Val Ser Ala Leu Leu Gln Cys Gly Ala Asp Pro Asn Ala Ala
                 645                 650                 655    
 Glu Gln Ser Gly Trp Thr Pro Leu His Leu Ala Val Gln Arg Ser Thr
             660                 665                 670        
 Phe Leu Ser Val Ile Asn Leu Leu Glu His His Ala Asn Val His Ala
         675                 680                 685            
 Arg Asn Lys Val Gly Trp Thr Pro Ala His Leu Ala Ala Leu Lys Gly
     690                 695                 700                
 Asn Thr Ala Ile Leu Lys Val Leu Val Glu Ala Gly Ala Gln Leu Asp
 705                 710                 715                 720
 Val Gln Asp Gly Val Ser Cys Thr Pro Leu Gln Leu Ala Leu Arg Ser
                 725                 730                 735    
 Arg Lys Gln Gly Ile Met Ser Phe Leu Glu Gly Lys Glu Pro Ser Val
             740                 745                 750        
 Ala Thr Leu Gly Gly Ser Lys Pro Gly Ala Glu Met Glu Ile
         755                 760                 765    



      <210> 930
      <211> 141
      <212> PRT
      <213> Homo sapiens


      <400> 930
 Met Pro Leu Leu Pro His Pro Gln His Val Glu Ser Arg Thr Gly His
   1               5                  10                  15    
 Arg Arg Tyr His Gly Asn Leu Asn Pro Ala Pro Gln Glu Tyr Glu Ser
              20                  25                  30        
 Glu Asp Asp Ser Tyr Glu Val Leu Asp Leu Thr Glu Tyr Ala Arg Arg
          35                  40                  45            
 His Gln Trp Trp Asn Pro Val Phe Gly His Ser Ser Gly Ser Met Val
      50                  55                  60                
 Glu Lys Tyr Ala Val Ala Thr Gln Ile Ile Ala Ser His Ser Gly Tyr
  65                  70                  75                  80
 Val Gln Ile Asn Trp Lys Arg Val Glu Lys Asp Ser Asn Lys Ala Lys
                  85                  90                  95    
 Arg Gln Met Lys Lys Arg Ala Asn Lys Ala Ala Pro Glu Ile Asn Asn
             100                 105                 110        
 Leu Ile Glu Glu Ala Ile Glu Phe Ile Lys Gln His Ile Val Ile Pro
         115                 120                 125            
 Gly Arg Phe Val Gly Gly Phe Leu Leu Gly Leu Ala Ser
     130                 135                 140    



      <210> 931
      <211> 154
      <212> PRT
      <213> Homo sapiens


      <400> 931
 Met Pro Ser Arg Thr Ala Arg Tyr Ala Arg Tyr Ser Pro Arg Gln Arg
   1               5                  10                  15    
 Arg Arg Arg Met Leu Ala Asp Arg Ser Val Arg Phe Pro Asn Asp Val
              20                  25                  30        
 Leu Phe Leu Asp His Ile Arg Gln Gly Asp Leu Glu Gln Val Gly Arg
          35                  40                  45            
 Phe Ile Arg Thr Arg Lys Val Ser Leu Ala Thr Ile His Pro Ser Gly
      50                  55                  60                
 Leu Ala Ala Leu His Glu Ala Val Leu Ser Gly Asn Leu Glu Cys Val
  65                  70                  75                  80
 Lys Leu Leu Val Lys Tyr Gly Ala Asp Ile His Gln Arg Asp Glu Ala
                  85                  90                  95    
 Gly Trp Thr Pro Leu His Ile Ala Cys Ser Asp Gly Tyr Pro Asp Ile
             100                 105                 110        
 Ala Arg Tyr Leu Ile Ser Leu Gly Ala Asp Arg Asp Ala Thr Asn Asp
         115                 120                 125            
 Asp Gly Asp Leu Pro Ser Asp Leu Ile Asp Pro Asp Tyr Lys Glu Leu
     130                 135                 140                
 Val Glu Leu Phe Lys Gly Thr Thr Met Asp
 145                 150                



      <210> 932
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 932
 Met Ala Ser Ala Lys Lys Gly Gly Gln Lys Lys Lys Gly Arg Ser Ala
   1               5                  10                  15    
 Ile Asn Glu Val Val Thr Gln Glu Tyr Thr Ile Asn Ile His Lys Arg
              20                  25                  30        
 Thr His Gly Val Arg Phe Lys Lys Cys Ala Pro Trp Ala Leu Lys Glu
          35                  40                  45            
 Ile Arg Lys Phe Ala Met Lys Glu Met Val Ala Pro Asp Met Cys Val
      50                  55                  60                
 Ala Thr Arg Leu Asn Lys Ala Val Trp Ala Lys Gly Ile Arg Asn Val
  65                  70                  75                  80
 Pro Tyr Arg Ile Arg Val Arg Leu Ser Arg Lys Arg Asn Glu Asp Glu
                  85                  90                  95    
 Asp Ser Pro Asn Lys Leu Tyr Thr Leu Val Thr Tyr Val Pro Val Thr
             100                 105                 110        
 Thr Phe Lys Ser Lys Phe Ser Ile Pro
         115                 120    



      <210> 933
      <211> 81
      <212> PRT
      <213> Homo sapiens


      <400> 933
 Met Val Ser Asn Arg Ala Ile Thr Leu Thr Ala Trp Pro Lys Ile Pro
   1               5                  10                  15    
 Phe Leu Gly Ile Arg Glu Ala Lys Asn Pro Arg Ser Glu Asn Met Arg
              20                  25                  30        
 Leu Ala Thr Ile Leu Glu Val Ala Ser Ala Ile Leu Glu Ala Ala His
          35                  40                  45            
 His Arg Leu Gly Ser Gly Pro Pro Pro Ser Trp Glu Leu Trp Glu Gln
      50                  55                  60                
 Gly Pro Leu Gly Asn Lys Asn Thr Val Leu Arg Lys Ser Ile Glu Lys
  65                  70                  75                  80
 Glu
    



      <210> 934
      <211> 556
      <212> PRT
      <213> Homo sapiens


      <400> 934
 Met Glu Arg Asp Ser His Gly Asn Ala Ser Pro Ala Arg Thr Pro Ser
   1               5                  10                  15    
 Ala Gly Ala Ser Pro Ala Gln Ala Ser Pro Ala Gly Thr Pro Pro Gly
              20                  25                  30        
 Arg Ala Ser Pro Ala Gln Ala Ser Pro Ala Gln Ala Ser Pro Ala Gly
          35                  40                  45            
 Thr Pro Pro Gly Arg Ala Ser Pro Ala Gln Ala Ser Pro Ala Gly Thr
      50                  55                  60                
 Pro Pro Gly Arg Ala Ser Pro Gly Arg Ala Ser Pro Ala Gln Ala Ser
  65                  70                  75                  80
 Pro Ala Gln Ala Ser Pro Ala Gln Ala Ser Pro Ala Arg Ala Ser Pro
                  85                  90                  95    
 Ala Leu Ala Ser Leu Ser Arg Ser Ser Ser Gly Arg Ser Ser Ser Ala
             100                 105                 110        
 Arg Ser Ala Ser Val Thr Thr Ser Pro Thr Arg Val Tyr Leu Val Arg
         115                 120                 125            
 Ala Thr Pro Val Gly Ala Val Pro Ile Arg Ser Ser Pro Ala Arg Ser
     130                 135                 140                
 Ala Pro Ala Thr Arg Ala Thr Arg Glu Ser Pro Val Gln Phe Trp Gln
 145                 150                 155                 160
 Gly His Thr Gly Ile Arg Tyr Lys Glu Gln Arg Glu Ser Cys Pro Lys
                 165                 170                 175    
 His Ala Val Arg Cys Asp Gly Val Val Asp Cys Lys Leu Lys Ser Asp
             180                 185                 190        
 Glu Leu Gly Cys Val Arg Phe Asp Trp Asp Lys Ser Leu Leu Lys Ile
         195                 200                 205            
 Tyr Ser Gly Ser Ser His Gln Trp Leu Pro Ile Cys Ser Ser Asn Trp
     210                 215                 220                
 Asn Asp Ser Tyr Ser Glu Lys Thr Cys Gln Gln Leu Gly Phe Glu Ser
 225                 230                 235                 240
 Ala His Arg Thr Thr Glu Val Ala His Arg Asp Phe Ala Asn Ser Phe
                 245                 250                 255    
 Ser Ile Leu Arg Tyr Asn Ser Thr Ile Gln Glu Ser Leu His Arg Ser
             260                 265                 270        
 Glu Cys Pro Ser Gln Arg Tyr Ile Ser Leu Gln Cys Ser His Cys Gly
         275                 280                 285            
 Leu Arg Ala Met Thr Gly Arg Ile Val Gly Gly Ala Leu Ala Ser Asp
     290                 295                 300                
 Ser Lys Trp Pro Trp Gln Val Ser Leu His Phe Gly Thr Thr His Ile
 305                 310                 315                 320
 Cys Gly Gly Thr Leu Ile Asp Ala Gln Trp Val Leu Thr Ala Ala His
                 325                 330                 335    
 Cys Phe Phe Val Thr Arg Glu Lys Val Leu Glu Gly Trp Lys Val Tyr
             340                 345                 350        
 Ala Gly Thr Ser Asn Leu His Gln Leu Pro Glu Ala Ala Ser Ile Ala
         355                 360                 365            
 Glu Ile Ile Ile Asn Ser Asn Tyr Thr Asp Glu Glu Asp Asp Tyr Asp
     370                 375                 380                
 Ile Ala Leu Met Arg Leu Ser Lys Pro Leu Thr Leu Ser Ala His Ile
 385                 390                 395                 400
 His Pro Ala Cys Leu Pro Met His Gly Gln Thr Phe Ser Leu Asn Glu
                 405                 410                 415    
 Thr Cys Trp Ile Thr Gly Phe Gly Lys Thr Arg Glu Thr Asp Asp Lys
             420                 425                 430        
 Thr Ser Pro Phe Leu Arg Glu Val Gln Val Asn Leu Ile Asp Phe Lys
         435                 440                 445            
 Lys Cys Asn Asp Tyr Leu Val Tyr Asp Ser Tyr Leu Thr Pro Arg Met
     450                 455                 460                
 Met Cys Ala Gly Asp Leu Arg Gly Gly Arg Asp Ser Cys Gln Gly Asp
 465                 470                 475                 480
 Ser Gly Gly Pro Leu Val Cys Glu Gln Asn Asn Arg Trp Tyr Leu Ala
                 485                 490                 495    
 Gly Val Thr Ser Trp Gly Thr Gly Cys Gly Gln Arg Asn Lys Pro Gly
             500                 505                 510        
 Val Tyr Thr Lys Val Thr Glu Val Leu Pro Trp Ile Tyr Ser Lys Met
         515                 520                 525            
 Glu Val Arg Ser Leu Gln Gln Asp Thr Ala Pro Ser Arg Leu Gly Thr
     530                 535                 540                
 Ser Ser Gly Gly Asp Pro Gly Gly Ala Pro Arg Val
 545                 550                 555    



      <210> 935
      <211> 309
      <212> PRT
      <213> Homo sapiens


      <400> 935
 Met Ala Gly Ile Ser Arg Pro Asp Pro Pro Val Arg Ala Trp Gly Ala
   1               5                  10                  15    
 Arg Lys Gly Thr Asn Phe Leu Ala His Glu Lys Ile Trp Phe Asp Lys
              20                  25                  30        
 Phe Lys Tyr Asp Asp Ala Glu Arg Arg Phe Tyr Glu Gln Met Asn Gly
          35                  40                  45            
 Pro Val Arg Gly Ala Ser Arg Gln Glu Asn Gly Ala Ser Val Ile Leu
      50                  55                  60                
 Arg Asp Ile Ala Arg Ala Arg Glu Asn Ile Gln Lys Ser Leu Ala Gly
  65                  70                  75                  80
 Ser Ser Gly Pro Gly Ala Ser Ser Gly Thr Ser Gly Asp His Gly Glu
                  85                  90                  95    
 Leu Val Val Arg Ile Ala Ser Leu Glu Val Glu Asn Gln Ser Leu Arg
             100                 105                 110        
 Gly Val Val Gln Glu Leu Gln Gln Ala Ile Ser Lys Leu Glu Ala Arg
         115                 120                 125            
 Leu Asn Val Leu Glu Lys Ser Ser Pro Gly His Arg Ala Thr Ala Pro
     130                 135                 140                
 Gln Thr Gln His Val Ser Pro Met Arg Gln Val Glu Pro Pro Ala Lys
 145                 150                 155                 160
 Lys Pro Ala Thr Pro Ala Glu Asp Asp Glu Asp Asp Asp Ile Asp Leu
                 165                 170                 175    
 Phe Gly Ser Asp Asn Glu Glu Glu Asp Lys Glu Ala Ala Gln Leu Arg
             180                 185                 190        
 Glu Glu Arg Leu Arg Gln Tyr Ala Glu Lys Lys Ala Lys Lys Pro Ala
         195                 200                 205            
 Leu Val Ala Lys Ser Ser Ile Leu Leu Asp Val Asn Pro Trp Asp Asp
     210                 215                 220                
 Glu Thr Asp Met Ala Gln Leu Glu Ala Cys Val Arg Ser Ile Gln Leu
 225                 230                 235                 240
 Asp Gly Leu Val Trp Gly Ala Ser Lys Leu Val Pro Val Gly Tyr Gly
                 245                 250                 255    
 Ile Arg Lys Leu Gln Ile Gln Cys Leu Val Glu Asp Ala Lys Val Gly
             260                 265                 270        
 Thr Asn Leu Val Glu Glu Glu Ile Pro Lys Phe Glu Glu Arg Val Gln
         275                 280                 285            
 Ser Val Asp Ile Pro Ala Phe Asn Lys Ile Leu Ser Leu Ser Val Cys
     290                 295                 300                
 Thr Arg Gly Arg Ala
 305                



      <210> 936
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 936
 Met Gln His His Thr Gly Ala Gly Val Ser Gln Ser Leu Arg His Lys
   1               5                  10                  15    
 Val Ala Lys Lys Gly Lys Asp Val Ala Leu Arg Tyr Asp Pro Ile Ser
              20                  25                  30        
 Gly His Asn Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Leu
          35                  40                  45            
 Glu Phe Pro Ile Tyr Phe Gln Gly Lys Asp Ala Ala Asp Lys Ser Gly
      50                  55                  60                
 Leu Pro Arg Asp Arg Phe Ser Ala Gln Arg Ser Glu Gly Ser Ile Ser
  65                  70                  75                  80
 Thr Leu Lys Phe Gln Arg Thr Gln Gln Gly Asp Leu Ala Val Tyr Leu
                  85                  90                  95    
 Cys Ala Ser Ser Ser Ala Thr Ala Leu Leu Leu Gln Cys Gln Leu Gly
             100                 105                 110        
 Ser Leu Gly Asn Gly Val Ser Arg Thr
         115                 120    



      <210> 937
      <211> 679
      <212> PRT
      <213> Homo sapiens


      <400> 937
 Met Ser Gly Glu Tyr Thr Asn Ser Val Ser Ile Ser Val Ile Asn Ser
   1               5                  10                  15    
 Ser Met Ala Gly Met Ala Gly Thr Gly Ala Gly Phe Gly Phe Ser Asn
              20                  25                  30        
 Ala Gly Thr Tyr Gly Tyr Trp Pro Ser Ser Val Ser Gly Gly Tyr Ser
          35                  40                  45            
 Met Leu Pro Gly Gly Cys Val Thr Gly Ser Gly Asn Cys Ser Pro His
      50                  55                  60                
 Thr His Pro Glu Gly Gln Pro His Trp Lys Phe Pro Gly Val Ile Leu
  65                  70                  75                  80
 Gly Val Ile Thr Pro Val Ile Gly Gly Gln Gln Val Glu Ile Arg Ser
                  85                  90                  95    
 Leu Ser His Asp Asn Ala Gly Gly Ile His Gly Glu Phe Thr Val Glu
             100                 105                 110        
 Gln Thr Lys Ile Ser His Arg Tyr Leu Arg Ala Met Ser Arg Gln Leu
         115                 120                 125            
 Thr His Phe Pro Arg Gly Glu Arg Leu Gly Phe Ser Gly Cys Ser Ala
     130                 135                 140                
 Val Leu Ser Gly Gly Ile Gly Ser Ser Ser Ala Ser Phe Arg Ala Arg
 145                 150                 155                 160
 Val Lys Gly Ser Ala Ser Phe Gly Ser Lys Ser Leu Ser Cys Leu Gly
                 165                 170                 175    
 Gly Ser Arg Ser Leu Ala Leu Ser Ala Ala Ala Arg Arg Gly Gly Gly
             180                 185                 190        
 Arg Leu Gly Gly Phe Val Gly Thr Ala Phe Gly Ser Ala Gly Leu Gly
         195                 200                 205            
 Pro Lys Cys Pro Ser Val Cys Pro Pro Gly Gly Ile Pro Gln Val Thr
     210                 215                 220                
 Val Asn Lys Ser Leu Leu Ala Pro Leu Asn Val Glu Met Asp Pro Glu
 225                 230                 235                 240
 Ile Gln Arg Val Arg Ala Gln Glu Arg Glu Gln Ile Lys Ala Leu Asn
                 245                 250                 255    
 Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln
             260                 265                 270        
 Asn Gln Val Leu Glu Thr Lys Trp Asn Leu Leu Gln Gln Leu Asp Leu
         275                 280                 285            
 Asn Asn Cys Arg Lys Asn Leu Glu Pro Ile Tyr Glu Gly Tyr Ile Ser
     290                 295                 300                
 Asn Leu Gln Lys Gln Leu Glu Met Leu Ser Gly Asp Gly Val Arg Leu
 305                 310                 315                 320
 Asp Ser Glu Leu Arg Asn Met Gln Asp Leu Val Glu Asp Tyr Lys Lys
                 325                 330                 335    
 Arg Thr Leu Ala Gln Ala Leu His Gly Glu Pro Lys Glu Gly Gly Asp
             340                 345                 350        
 Thr Val Pro Asp Leu Arg Glu His Thr Asp Cys Glu Asp Arg Leu Lys
         355                 360                 365            
 Glu Gln Phe Gln Ile Ala Thr Asn Lys Lys Lys Gln Ile Trp Tyr Glu
     370                 375                 380                
 Val Glu Ile Asn Arg Arg Thr Ala Ala Glu Asn Glu Phe Val Val Leu
 385                 390                 395                 400
 Lys Lys Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu Leu Gln Ala
                 405                 410                 415    
 Lys Val Asp Ser Leu Thr Asp Glu Ile Lys Phe Phe Lys Cys Leu Tyr
             420                 425                 430        
 Glu Gly Glu Ile Thr Gln Ile Gln Ser His Ile Ser Asp Thr Ser Ile
         435                 440                 445            
 Val Leu Ser Met Asp Asn Asn Arg Asp Leu Asp Leu Asp Ser Ile Ile
     450                 455                 460                
 Ala Glu Val Arg Ala Gln Tyr Glu Glu Ile Ala Leu Lys Ser Lys Ala
 465                 470                 475                 480
 Glu Ala Glu Thr Leu Tyr Gln Thr Lys Ile Gln Glu Leu Gln Val Thr
                 485                 490                 495    
 Ala Gly Gln His Gly Asp Asp Leu Lys Leu Thr Lys Ala Glu Ile Ser
             500                 505                 510        
 Glu Leu Asn Arg Leu Ile Gln Arg Ile Arg Ser Glu Ile Gly Asn Val
         515                 520                 525            
 Lys Lys Gln Cys Ala Asp Leu Glu Thr Ala Ile Ala Asp Ala Glu Gln
     530                 535                 540                
 Arg Gly Asp Cys Ala Leu Lys Asp Ala Arg Ala Lys Leu Asp Glu Leu
 545                 550                 555                 560
 Glu Gly Ala Leu His Gln Ala Lys Glu Glu Leu Ala Arg Met Leu Arg
                 565                 570                 575    
 Glu Tyr Gln Glu Leu Val Ser Leu Lys Leu Ala Leu Asp Met Glu Ile
             580                 585                 590        
 Ala Thr Tyr Arg Lys Leu Leu Glu Ser Glu Glu Cys Arg Met Ser Gly
         595                 600                 605            
 Glu Tyr Pro Asn Ser Val Ser Ile Ser Val Ile Ser Ser Thr Asn Ala
     610                 615                 620                
 Gly Ala Gly Gly Ala Gly Phe Ser Met Gly Phe Gly Ala Ser Ser Ser
 625                 630                 635                 640
 Tyr Ser Tyr Lys Thr Ala Ala Ala Asp Val Lys Thr Lys Gly Ser Cys
                 645                 650                 655    
 Gly Ser Glu Leu Lys Asp Pro Leu Ala Lys Thr Ser Gly Ser Ser Cys
             660                 665                 670        
 Ala Thr Lys Lys Ala Ser Arg
         675                



      <210> 938
      <211> 815
      <212> PRT
      <213> Homo sapiens


      <400> 938
 Met Ala Asn Ser Val Glu Glu Ala Gln Ile Trp Met Arg Gly Leu Gln
   1               5                  10                  15    
 Leu Leu Val Asp Leu Val Thr Ser Met Asp His Gln Glu Arg Leu Asp
              20                  25                  30        
 Gln Tyr Arg Gln Asp Gly Val Arg Val Gly Val Ile Trp Cys Gln Leu
          35                  40                  45            
 Val Glu Gln Trp Val Met Ala Ser Leu Leu Gln Asp Gln Leu Thr Thr
      50                  55                  60                
 Asp Gln Asp Leu Leu Leu Met Gln Glu Gly Met Pro Met Arg Lys Val
  65                  70                  75                  80
 Arg Ser Lys Ser Trp Lys Lys Leu Arg Tyr Phe Arg Leu Gln Asn Asp
                  85                  90                  95    
 Gly Met Thr Val Trp His Ala Arg Gln Ala Arg Gly Ser Ala Lys Pro
             100                 105                 110        
 Ser Phe Ser Ile Ser Asp Val Glu Thr Ile Arg Asn Gly His Asp Ser
         115                 120                 125            
 Glu Leu Leu Arg Ser Leu Ala Glu Glu Leu Pro Leu Glu Gln Gly Phe
     130                 135                 140                
 Thr Ile Val Phe His Gly Arg Arg Ser Asn Leu Asp Leu Met Ala Asn
 145                 150                 155                 160
 Ser Val Glu Glu Ala Gln Ile Trp Met Arg Gly Leu Gln Leu Leu Val
                 165                 170                 175    
 Asp Leu Val Thr Ser Met Asp His Gln Glu Arg Leu Asp Gln Trp Leu
             180                 185                 190        
 Ser Asp Trp Phe Gln Arg Gly Asp Lys Asn Gln Asp Gly Lys Met Ser
         195                 200                 205            
 Phe Gln Glu Val Gln Arg Leu Leu His Leu Met Asn Val Glu Met Asp
     210                 215                 220                
 Gln Glu Tyr Ala Phe Ser Leu Phe Gln Ala Ala Asp Thr Ser Gln Ser
 225                 230                 235                 240
 Gly Thr Leu Glu Gly Glu Glu Phe Val Gln Phe Tyr Lys Ala Leu Thr
                 245                 250                 255    
 Lys Arg Ala Glu Val Gln Glu Leu Phe Glu Ser Phe Ser Ala Asp Gly
             260                 265                 270        
 Gln Lys Leu Thr Leu Leu Glu Phe Leu Asp Phe Leu Gln Glu Glu Gln
         275                 280                 285            
 Lys Glu Arg Asp Cys Thr Ser Glu Leu Ala Leu Glu Leu Ile Asp Arg
     290                 295                 300                
 Tyr Glu Pro Ser Asp Ser Gly Lys Leu Arg His Val Leu Ser Met Asp
 305                 310                 315                 320
 Gly Phe Leu Ser Tyr Leu Cys Ser Lys Asp Gly Asp Ile Phe Asn Pro
                 325                 330                 335    
 Ala Cys Leu Pro Ile Tyr Gln Asp Met Thr Gln Pro Leu Asn His Tyr
             340                 345                 350        
 Phe Ile Cys Ser Ser His Asn Thr Tyr Leu Val Gly Asp Gln Leu Cys
         355                 360                 365            
 Gly Gln Ser Ser Val Glu Gly Tyr Ile Arg Ala Leu Lys Arg Gly Cys
     370                 375                 380                
 Arg Cys Val Glu Val Asp Val Trp Asp Gly Pro Ser Gly Glu Pro Val
 385                 390                 395                 400
 Val Tyr His Gly His Thr Leu Thr Ser Arg Ile Leu Phe Lys Asp Val
                 405                 410                 415    
 Val Ala Thr Val Ala Gln Tyr Ala Phe Gln Thr Ser Asp Tyr Pro Val
             420                 425                 430        
 Ile Leu Ser Leu Glu Thr His Cys Ser Trp Glu Gln Gln Gln Thr Met
         435                 440                 445            
 Ala Arg His Leu Thr Glu Ile Leu Gly Glu Gln Leu Leu Ser Thr Thr
     450                 455                 460                
 Leu Asp Gly Val Leu Pro Thr Gln Leu Pro Ser Pro Glu Glu Leu Arg
 465                 470                 475                 480
 Arg Lys Ile Leu Val Lys Gly Lys Lys Leu Thr Leu Glu Glu Asp Leu
                 485                 490                 495    
 Glu Tyr Glu Glu Glu Glu Ala Glu Pro Glu Leu Glu Glu Ser Glu Leu
             500                 505                 510        
 Ala Leu Glu Ser Gln Phe Glu Thr Glu Pro Glu Pro Gln Glu Gln Asn
         515                 520                 525            
 Leu Gln Asn Lys Asp Lys Lys Lys Lys Ser Lys Pro Ile Leu Cys Pro
     530                 535                 540                
 Ala Leu Ser Ser Leu Val Ile Tyr Leu Lys Ser Val Ser Phe Arg Ser
 545                 550                 555                 560
 Phe Thr His Ser Lys Glu His Tyr His Phe Tyr Glu Ile Ser Ser Phe
                 565                 570                 575    
 Ser Glu Thr Lys Ala Lys Arg Leu Ile Lys Glu Ala Gly Asn Glu Phe
             580                 585                 590        
 Val Gln His Asn Thr Trp Gln Leu Ser Arg Val Tyr Pro Ser Gly Leu
         595                 600                 605            
 Arg Thr Asp Ser Ser Asn Tyr Asn Pro Gln Glu Leu Trp Asn Ala Gly
     610                 615                 620                
 Cys Gln Met Val Ala Met Asn Met Gln Thr Ala Gly Leu Glu Met Asp
 625                 630                 635                 640
 Ile Cys Asp Gly His Phe Arg Gln Asn Gly Gly Cys Gly Tyr Val Leu
                 645                 650                 655    
 Lys Pro Asp Phe Leu Arg Asp Ile Gln Ser Ser Phe His Pro Glu Lys
             660                 665                 670        
 Pro Ile Ser Pro Phe Lys Ala Gln Thr Leu Leu Ile Gln Val Ile Ser
         675                 680                 685            
 Gly Gln Gln Leu Pro Lys Val Asp Lys Thr Lys Glu Gly Ser Ile Val
     690                 695                 700                
 Asp Pro Leu Val Lys Val Gln Ile Phe Gly Val Arg Leu Asp Thr Ala
 705                 710                 715                 720
 Arg Gln Glu Thr Asn Tyr Val Glu Asn Asn Gly Phe Asn Pro Tyr Trp
                 725                 730                 735    
 Gly Gln Thr Leu Cys Phe Arg Val Leu Val Pro Glu Leu Ala Met Leu
             740                 745                 750        
 Arg Phe Val Val Met Asp Tyr Asp Trp Lys Ser Arg Asn Asp Phe Ile
         755                 760                 765            
 Gly Gln Tyr Thr Leu Pro Trp Thr Cys Met Gln Gln Gly Tyr Arg His
     770                 775                 780                
 Ile His Leu Leu Ser Lys Asp Gly Ile Ser Leu Arg Pro Ala Ser Ile
 785                 790                 795                 800
 Phe Val Tyr Ile Cys Ile Gln Glu Gly Leu Glu Gly Asp Glu Ser
                 805                 810                 815



      <210> 939
      <211> 115
      <212> PRT
      <213> Homo sapiens


      <400> 939
 Met Cys Asp Phe Thr Glu Asp Gln Thr Ala Glu Phe Lys Glu Ala Phe
   1               5                  10                  15    
 Gln Leu Phe Asp Arg Thr Glu Met Asn Val Lys Val Leu Asp Phe Glu
              20                  25                  30        
 His Phe Leu Pro Met Leu Gln Thr Val Ala Lys Asn Lys Asp Gln Gly
          35                  40                  45            
 Thr Tyr Glu Asp Tyr Val Glu Gly Leu Arg Val Phe Asp Lys Glu Gly
      50                  55                  60                
 Asn Gly Thr Val Met Gly Ala Glu Ile Arg His Val Leu Val Thr Leu
  65                  70                  75                  80
 Gly Glu Lys Met Thr Glu Glu Glu Val Glu Met Leu Val Ala Gly His
                  85                  90                  95    
 Glu Asp Ser Asn Gly Cys Ile Asn Tyr Glu Ala Phe Val Arg His Ile
             100                 105                 110        
 Leu Ser Gly
         115



      <210> 940
      <211> 110
      <212> PRT
      <213> Homo sapiens


      <400> 940
 Met Leu Arg Leu Pro Pro Thr Gly Thr Met Pro Pro Val Arg Met Gln
   1               5                  10                  15    
 His Ser Leu Ala Gly Gln Thr Tyr Ala Val Pro Leu Ile Gln Pro Asp
              20                  25                  30        
 Leu Arg Arg Glu Glu Ala Val Gln Gln Met Ala Asp Ala Leu Gln Tyr
          35                  40                  45            
 Leu Gln Lys Val Ser Gly Asp Ile Phe Ser Arg Cys Ser Pro Val Pro
      50                  55                  60                
 Ser Thr Leu Leu Gln Ser Ala Cys Arg Asn Met Ala Pro Ser Ser Pro
  65                  70                  75                  80
 Ala Pro Arg Thr Leu Ala Cys Arg Asp Ala Pro Ala Thr Gly Ser Arg
                  85                  90                  95    
 Ala Ser Thr Ala Pro Trp Thr Ser Gly Pro Cys Arg Arg Ser
             100                 105                 110



      <210> 941
      <211> 274
      <212> PRT
      <213> Homo sapiens


      <400> 941
 Met Asp Gln Lys Gly Val Thr Val Gln Ala Leu Ser Thr Val Pro Val
   1               5                  10                  15    
 Met Phe Ser Tyr Trp Ala Lys Pro Glu Asp Thr Leu Asn Leu Cys Gln
              20                  25                  30        
 Leu Leu Asn Asn Asp Leu Ala Ser Thr Val Val Ser Tyr Pro Arg Arg
          35                  40                  45            
 Phe Val Gly Leu Gly Thr Leu Pro Met Gln Ala Pro Glu Leu Ala Val
      50                  55                  60                
 Lys Glu Met Glu Arg Cys Val Lys Glu Leu Gly Phe Pro Gly Val Gln
  65                  70                  75                  80
 Ile Gly Thr His Val Asn Glu Trp Asp Leu Asn Ala Gln Glu Leu Phe
                  85                  90                  95    
 Pro Val Tyr Ala Ala Ala Glu Arg Leu Lys Cys Ser Leu Phe Val His
             100                 105                 110        
 Pro Trp Asp Met Gln Met Asp Gly Arg Met Ala Lys Tyr Trp Leu Pro
         115                 120                 125            
 Trp Leu Val Gly Met Pro Ala Glu Thr Thr Ile Ala Ile Cys Ser Met
     130                 135                 140                
 Ile Met Gly Gly Val Phe Glu Lys Phe Pro Lys Leu Lys Val Cys Phe
 145                 150                 155                 160
 Ala His Gly Gly Gly Ala Phe Pro Phe Thr Val Gly Arg Ile Ser His
                 165                 170                 175    
 Gly Phe Ser Met Arg Pro Asp Leu Cys Ala Gln Asp Asn Pro Met Asn
             180                 185                 190        
 Pro Lys Lys Tyr Leu Gly Ser Phe Tyr Thr Asp Ala Leu Val His Asp
         195                 200                 205            
 Pro Leu Ser Leu Lys Leu Leu Thr Asp Val Ile Gly Lys Asp Lys Val
     210                 215                 220                
 Ile Leu Gly Thr Asp Tyr Pro Phe Pro Leu Gly Glu Leu Glu Pro Gly
 225                 230                 235                 240
 Lys Leu Ile Glu Ser Met Glu Glu Phe Asp Glu Glu Thr Lys Asn Lys
                 245                 250                 255    
 Leu Lys Ala Gly Asn Ala Leu Ala Phe Leu Gly Leu Glu Arg Lys Gln
             260                 265                 270        
 Phe Glu
        



      <210> 942
      <211> 254
      <212> PRT
      <213> Homo sapiens


      <400> 942
 Met Pro Thr Thr Gln Gln Ser Pro Gln Asp Glu Gln Glu Lys Leu Leu
   1               5                  10                  15    
 Asp Glu Ala Ile Gln Ala Val Lys Val Gln Ser Phe Gln Met Lys Arg
              20                  25                  30        
 Cys Leu Asp Lys Asn Lys Leu Met Asp Ala Leu Lys His Ala Ser Asn
          35                  40                  45            
 Met Leu Gly Glu Leu Arg Thr Ser Met Leu Ser Pro Lys Ser Tyr Tyr
      50                  55                  60                
 Glu Leu Tyr Met Ala Ile Ser Asp Glu Leu His Tyr Leu Glu Val Tyr
  65                  70                  75                  80
 Leu Thr Asp Glu Phe Ala Lys Gly Arg Lys Val Ala Asp Leu Tyr Glu
                  85                  90                  95    
 Leu Val Gln Tyr Ala Gly Asn Ile Ile Pro Arg Leu Tyr Leu Leu Ile
             100                 105                 110        
 Thr Val Gly Val Val Tyr Val Lys Ser Phe Pro Gln Ser Arg Lys Asp
         115                 120                 125            
 Ile Leu Lys Asp Leu Val Glu Met Cys Arg Gly Val Gln His Pro Leu
     130                 135                 140                
 Arg Gly Leu Phe Leu Arg Asn Tyr Leu Leu Gln Cys Thr Arg Asn Ile
 145                 150                 155                 160
 Leu Pro Asp Glu Gly Glu Pro Thr Asp Glu Glu Thr Thr Gly Asp Ile
                 165                 170                 175    
 Ser Asp Ser Met Asp Phe Val Leu Leu Asn Phe Ala Glu Met Asn Lys
             180                 185                 190        
 Leu Trp Val Arg Met Gln His Gln Gly His Ser Arg Asp Arg Glu Lys
         195                 200                 205            
 Arg Glu Arg Glu Arg Gln Glu Leu Arg Ile Leu Val Gly Thr Asn Leu
     210                 215                 220                
 Val Arg Leu Thr Leu Val Ser Trp Arg Cys Lys Cys Gly Thr Leu Gln
 225                 230                 235                 240
 Thr Asp Cys Phe Asp Trp His Ile Gly Ala Ser Cys Lys Leu
                 245                 250                



      <210> 943
      <211> 229
      <212> PRT
      <213> Homo sapiens


      <400> 943
 Met Phe Arg Arg Lys Leu Thr Ala Leu Asp Tyr His Asn Pro Ala Gly
   1               5                  10                  15    
 Phe Asn Cys Lys Asp Glu Thr Glu Phe Arg Asn Phe Ile Val Trp Leu
              20                  25                  30        
 Glu Asp Gln Lys Ile Arg His Tyr Lys Ile Glu Asp Arg Gly Asn Leu
          35                  40                  45            
 Arg Asn Ile His Ser Ser Asp Trp Pro Lys Phe Phe Glu Lys Tyr Leu
      50                  55                  60                
 Arg Asp Val Asn Cys Pro Phe Lys Ile Gln Asp Arg Gln Glu Ala Ile
  65                  70                  75                  80
 Asp Trp Leu Leu Gly Leu Ala Val Arg Leu Glu Tyr Gly Asp Asn Ala
                  85                  90                  95    
 Glu Lys Tyr Lys Asp Leu Val Pro Asp Asn Ser Lys Thr Ala Asp Asn
             100                 105                 110        
 Ala Thr Lys Asn Ala Glu Pro Leu Ile Asn Leu Asp Val Asn Asn Pro
         115                 120                 125            
 Asp Phe Lys Ala Gly Val Met Ala Leu Ala Asn Leu Leu Gln Ile Gln
     130                 135                 140                
 Arg His Asp Asp Tyr Leu Val Met Leu Lys Ala Ile Arg Ile Leu Val
 145                 150                 155                 160
 Gln Glu Arg Leu Thr Gln Asp Ala Val Ala Lys Ala Asn Gln Thr Lys
                 165                 170                 175    
 Glu Gly Asp Ala Val Leu Asn Glu Ala Ala Gln Ile Leu Arg Leu Leu
             180                 185                 190        
 His Ile Glu Glu Leu Arg Glu Leu Gln Thr Lys Ile Asn Glu Ala Ile
         195                 200                 205            
 Val Ala Val Gln Ala Ile Ile Ala Asp Pro Lys Thr Asp His Arg Leu
     210                 215                 220                
 Gly Lys Val Gly Arg
 225                



      <210> 944
      <211> 408
      <212> PRT
      <213> Homo sapiens


      <400> 944
 Met Glu Leu Ala Thr Arg Tyr Gln Ile Pro Lys Glu Val Ala Asp Ile
   1               5                  10                  15    
 Phe Asn Ala Pro Ser Asp Asp Glu Glu Phe Val Gly Phe Arg Asp Asp
              20                  25                  30        
 Val Pro Met Glu Thr Leu Ser Ser Glu Glu Ser Cys Asp Ser Phe Asp
          35                  40                  45            
 Ser Leu Glu Ser Gly Lys Gln Val Val Glu Ser Asp Leu Ser Asp Asp
      50                  55                  60                
 Gly Lys Ala Ser Leu Val Ser Glu Glu Glu Glu Asp Glu Glu Glu Asp
  65                  70                  75                  80
 Lys Ala Thr Pro Arg Arg Ser Arg Ser Arg Arg Ser Ser Ile Gly Leu
                  85                  90                  95    
 Arg Val Ala Phe Gln Phe Pro Thr Lys Lys Leu Ala Asn Lys Pro Asp
             100                 105                 110        
 Lys Asn Ser Ser Ser Glu Gln Leu Phe Ser Ser Ala Arg Leu Gln Asn
         115                 120                 125            
 Glu Lys Lys Thr Ile Leu Glu Arg Lys Lys Asp Cys Arg Gln Val Ile
     130                 135                 140                
 Gln Arg Glu Asp Ser Thr Ser Glu Ser Glu Asp Asp Ser Arg Asp Glu
 145                 150                 155                 160
 Ser Gln Glu Ser Ser Asp Ala Leu Leu Lys Arg Thr Met Asn Ile Lys
                 165                 170                 175    
 Glu Asn Lys Ala Met Leu Ala Gln Leu Leu Ala Glu Leu Asn Ser Met
             180                 185                 190        
 Pro Asp Phe Phe Pro Val Arg Thr Pro Thr Ser Ala Ser Arg Lys Lys
         195                 200                 205            
 Thr Val Arg Arg Ala Phe Ser Glu Gly Gln Ile Thr Arg Arg Met Asn
     210                 215                 220                
 Pro Thr Arg Ser Ala Arg Pro Pro Glu Lys Phe Ala Leu Glu Asn Phe
 225                 230                 235                 240
 Thr Val Ser Ala Ala Lys Phe Ala Glu Glu Phe Tyr Ser Phe Arg Arg
                 245                 250                 255    
 Arg Lys Thr Ile Gly Gly Lys Cys Arg Glu Tyr Arg Arg Arg His Arg
             260                 265                 270        
 Ile Ser Ser Phe Arg Pro Val Glu Asp Ile Thr Glu Glu Asp Leu Glu
         275                 280                 285            
 Asn Val Ala Ile Thr Val Arg Asp Lys Ile Tyr Asp Lys Val Leu Gly
     290                 295                 300                
 Asn Thr Cys His Gln Cys Arg Gln Lys Thr Ile Asp Thr Lys Thr Val
 305                 310                 315                 320
 Cys Arg Asn Gln Gly Cys Cys Gly Val Arg Gly Gln Phe Cys Gly Pro
                 325                 330                 335    
 Cys Leu Arg Asn Arg Tyr Gly Glu Asp Val Arg Ser Ala Leu Leu Asp
             340                 345                 350        
 Pro Asp Trp Val Cys Pro Pro Cys Arg Gly Ile Cys Asn Cys Ser Tyr
         355                 360                 365            
 Cys Arg Lys Arg Asp Gly Arg Cys Ala Thr Gly Ile Leu Ile His Leu
     370                 375                 380                
 Ala Lys Phe Tyr Gly Tyr Asp Asn Val Lys Glu Tyr Leu Glu Ser Leu
 385                 390                 395                 400
 Gln Lys Glu Leu Val Glu Asp Asn
                 405            



      <210> 945
      <211> 164
      <212> PRT
      <213> Homo sapiens


      <400> 945
 Met Ala Ser Gly Asn Ala Arg Ile Gly Lys Pro Ala Pro Asp Phe Lys
   1               5                  10                  15    
 Ala Thr Ala Val Val Asp Gly Ala Phe Lys Glu Val Lys Leu Ser Asp
              20                  25                  30        
 Tyr Lys Gly Lys Tyr Val Val Leu Phe Phe Tyr Pro Leu Asp Phe Thr
          35                  40                  45            
 Phe Val Cys Pro Thr Glu Ile Thr Ala Val Ser Ser His Ala Glu Asp
      50                  55                  60                
 Phe Arg Lys Leu Gly Cys Glu Val Leu Gly Ile Leu Val Asp Ser Gln
  65                  70                  75                  80
 Phe Thr His Leu Ala Trp Ile Asn Ile Pro Arg Lys Glu Gly Gly Leu
                  85                  90                  95    
 Gly Pro Leu Asn Ile Pro Leu Leu Ala Asn Ile Thr Val Asn Asp Leu
             100                 105                 110        
 Pro Val Gly Arg Ser Leu Asp Glu Ala Leu Gln Leu Val Gln Thr Ile
         115                 120                 125            
 Gln Tyr Thr Asp Glu His Arg Glu Val Cys Pro Ala Gly Trp Lys Leu
     130                 135                 140                
 Gly Ser Asp Thr Ile Lys Leu Asn Val Asp Asp Gly Glu Glu Tyr Phe
 145                 150                 155                 160
 Ser Lys Gln Asn
                



      <210> 946
      <211> 287
      <212> PRT
      <213> Homo sapiens


      <400> 946
 Met Asp Thr Pro Ser Pro Asp Pro Leu Pro Ser Pro Leu Pro Gly Glu
   1               5                  10                  15    
 Glu Glu Lys Pro Leu Ala Leu Ser Pro Pro Val Pro Arg Gly Arg Arg
              20                  25                  30        
 Gly Arg Arg Pro Gly Gly Ala Thr Ser Ser Asn Arg Thr Leu Lys Ala
          35                  40                  45            
 Ser Leu Pro Arg Lys Arg Gly Arg Pro Pro Lys Ser Gly Gln Glu Pro
      50                  55                  60                
 Pro Leu Val Gln Val Gln Gly Val Thr Ala Pro Val Gly Ser Ser Gly
  65                  70                  75                  80
 Gly Ser Asp Leu Leu Leu Ile Asp Asp Gln Gly Val Pro Tyr Thr Val
                  85                  90                  95    
 Ser Glu Gly Ser Ala Ala Gly Pro Glu Gly Ser Gly Pro Arg Lys Ala
             100                 105                 110        
 Pro His Phe Cys Pro Val Cys Leu Arg Ala Phe Pro Tyr Leu Ser Asp
         115                 120                 125            
 Leu Glu Arg His Ser Ile Ser His Ser Glu Leu Lys Pro His Gln Cys
     130                 135                 140                
 Lys Val Cys Gly Lys Thr Phe Lys Arg Ser Ser His Leu Arg Arg His
 145                 150                 155                 160
 Cys Asn Ile His Ala Gly Leu Arg Pro Phe Arg Cys Pro Leu Cys Pro
                 165                 170                 175    
 Arg Arg Phe Arg Glu Ala Gly Glu Leu Ala His His His Arg Val His
             180                 185                 190        
 Ser Gly Glu Arg Pro Tyr Gln Cys Pro Ile Cys Arg Leu Arg Phe Thr
         195                 200                 205            
 Glu Ala Asn Thr Leu Arg Arg His Ala Lys Arg Lys His Pro Glu Ala
     210                 215                 220                
 Met Gly Val Pro Leu Cys Ala Pro Asp Pro Gly Ser Glu Pro Pro Trp
 225                 230                 235                 240
 Asp Glu Glu Gly Ile Pro Ala Thr Ala Gly Ala Glu Glu Pro Val Asp
                 245                 250                 255    
 Thr Leu Trp Lys Gly Glu Pro Ala Pro Ala Pro Cys Gln Ala Gln Ala
             260                 265                 270        
 Pro Gly Gly His Gly Gly Thr Pro Val Cys Thr Arg Ser Arg Val
         275                 280                 285        



      <210> 947
      <211> 440
      <212> PRT
      <213> Homo sapiens


      <400> 947
 Met Pro Gly Lys Cys Leu Tyr Ala Arg Leu Arg Glu Ala Ala Ala Arg
   1               5                  10                  15    
 Arg Arg Ser Leu Ser Pro Ala Thr Met Ser Thr Lys Gln Ile Thr Cys
              20                  25                  30        
 Arg Tyr Phe Met His Gly Val Cys Arg Glu Gly Ser Gln Cys Leu Phe
          35                  40                  45            
 Ser His Asp Leu Ala Asn Ser Lys Pro Ser Thr Ile Cys Lys Tyr Tyr
      50                  55                  60                
 Gln Lys Gly Tyr Cys Ala Tyr Gly Thr Arg Cys Arg Tyr Asp His Thr
  65                  70                  75                  80
 Arg Pro Ser Ala Ala Ala Gly Gly Ala Val Gly Thr Met Ala His Ser
                  85                  90                  95    
 Val Pro Ser Pro Ala Phe His Ser Pro His Pro Pro Ser Glu Val Thr
             100                 105                 110        
 Ala Ser Ile Val Lys Thr Asn Ser His Glu Pro Gly Lys Arg Glu Lys
         115                 120                 125            
 Arg Thr Leu Val Leu Arg Asp Arg Asn Leu Ser Gly Met Ala Glu Arg
     130                 135                 140                
 Lys Thr Gln Pro Ser Met Val Ser Asn Pro Gly Ser Cys Ser Asp Pro
 145                 150                 155                 160
 Gln Pro Ser Pro Glu Met Lys Pro His Ser Tyr Leu Asp Ala Ile Arg
                 165                 170                 175    
 Ser Gly Leu Asp Asp Val Glu Ala Ser Ser Ser Tyr Ser Asn Glu Gln
             180                 185                 190        
 Gln Leu Cys Pro Tyr Ala Ala Ala Gly Glu Cys Arg Phe Gly Asp Ala
         195                 200                 205            
 Cys Val Tyr Leu His Gly Glu Val Cys Glu Ile Cys Arg Leu Gln Val
     210                 215                 220                
 Leu His Pro Phe Asp Pro Glu Gln Arg Lys Ala His Glu Lys Ile Cys
 225                 230                 235                 240
 Met Leu Thr Phe Glu His Glu Met Glu Lys Ala Phe Ala Phe Gln Ala
                 245                 250                 255    
 Ser Gln Asp Lys Val Cys Ser Ile Cys Met Glu Val Ile Leu Glu Lys
             260                 265                 270        
 Ala Ser Ala Ser Glu Arg Arg Phe Gly Ile Leu Ser Asn Cys Asn His
         275                 280                 285            
 Thr Tyr Cys Leu Ser Cys Ile Arg Gln Trp Arg Cys Ala Lys Gln Phe
     290                 295                 300                
 Glu Asn Pro Ile Ile Lys Ser Cys Pro Glu Cys Arg Val Ile Ser Glu
 305                 310                 315                 320
 Phe Val Ile Pro Ser Val Tyr Trp Val Glu Asp Gln Asn Lys Lys Asn
                 325                 330                 335    
 Glu Leu Ile Glu Ala Phe Lys Gln Gly Met Gly Lys Lys Ala Cys Lys
             340                 345                 350        
 Tyr Phe Glu Gln Gly Lys Gly Thr Cys Pro Phe Gly Ser Lys Cys Leu
         355                 360                 365            
 Tyr Arg His Ala Tyr Pro Asp Gly Arg Leu Ala Glu Pro Glu Lys Pro
     370                 375                 380                
 Arg Lys Gln Leu Ser Ser Gln Gly Thr Val Arg Phe Phe Asn Ser Val
 385                 390                 395                 400
 Arg Leu Trp Asp Phe Ile Glu Asn Arg Glu Ser Arg His Val Pro Asn
                 405                 410                 415    
 Asn Glu Asp Val Asp Met Thr Glu Leu Gly Asp Leu Phe Met His Leu
             420                 425                 430        
 Ser Gly Val Glu Ser Ser Glu Pro
         435                 440



      <210> 948
      <211> 1489
      <212> PRT
      <213> Homo sapiens


      <400> 948
 Met Glu Lys Leu Gln Pro Leu Tyr Glu Thr Leu Lys Gln Arg Gly Glu
   1               5                  10                  15    
 Glu Met Ile Ala Arg Ser Gly Gly Thr Asp Lys Asp Ile Ser Ala Lys
              20                  25                  30        
 Ala Val Gln Asp Lys Leu Asp Gln Met Val Phe Ile Trp Glu Asn Ile
          35                  40                  45            
 His Thr Leu Val Glu Glu Arg Glu Ala Lys Leu Leu Asp Val Met Glu
      50                  55                  60                
 Leu Ala Glu Lys Phe Trp Cys Asp His Met Ser Leu Ile Val Thr Ile
  65                  70                  75                  80
 Lys Asp Thr Gln Asp Phe Ile Arg Asp Leu Glu Asp Pro Gly Ile Asp
                  85                  90                  95    
 Pro Ser Val Val Lys Gln Gln Gln Glu Ala Ala Glu Thr Ile Arg Glu
             100                 105                 110        
 Glu Ile Asp Gly Leu Gln Glu Glu Leu Asp Ile Val Ile Asn Leu Gly
         115                 120                 125            
 Ser Glu Leu Ile Ala Ala Cys Gly Glu Pro Asp Lys Pro Ile Val Lys
     130                 135                 140                
 Lys Ser Ile Asp Glu Leu Asn Ser Ala Trp Asp Ser Leu Asn Lys Ala
 145                 150                 155                 160
 Trp Lys Asp Arg Ile Asp Lys Leu Glu Glu Ala Met Gln Ala Ala Val
                 165                 170                 175    
 Gln Tyr Gln Asp Gly Leu Gln Ala Val Phe Asp Trp Val Asp Ile Ala
             180                 185                 190        
 Gly Gly Lys Leu Ala Ser Met Ser Pro Ile Gly Thr Asp Leu Glu Thr
         195                 200                 205            
 Val Lys Gln Gln Ile Glu Glu Leu Lys Gln Phe Lys Ser Glu Ala Tyr
     210                 215                 220                
 Gln Gln Gln Ile Glu Met Glu Arg Leu Asn His Gln Ala Glu Leu Leu
 225                 230                 235                 240
 Leu Lys Lys Val Thr Glu Glu Ser Asp Lys His Thr Val Gln Asp Pro
                 245                 250                 255    
 Leu Met Glu Leu Lys Leu Ile Trp Asp Ser Leu Glu Glu Arg Ile Ile
             260                 265                 270        
 Asn Arg Gln His Lys Leu Glu Gly Ala Leu Leu Ala Leu Gly Gln Phe
         275                 280                 285            
 Gln His Ala Leu Asp Glu Leu Leu Ala Trp Leu Thr His Thr Glu Gly
     290                 295                 300                
 Leu Leu Ser Glu Gln Lys Pro Val Gly Gly Asp Pro Lys Ala Ile Glu
 305                 310                 315                 320
 Ile Glu Leu Ala Lys His His Val Leu Gln Asn Asp Val Leu Ala His
                 325                 330                 335    
 Gln Ser Thr Val Glu Ala Val Asn Lys Ala Gly Asn Asp Leu Ile Glu
             340                 345                 350        
 Ser Ser Ala Gly Glu Glu Ala Ser Asn Leu Gln Asn Lys Leu Glu Val
         355                 360                 365            
 Leu Asn Gln Arg Trp Gln Asn Val Leu Glu Lys Thr Glu Gln Arg Lys
     370                 375                 380                
 Gln Gln Leu Asp Gly Ala Leu Arg Gln Ala Lys Gly Phe His Gly Glu
 385                 390                 395                 400
 Ile Glu Asp Leu Gln Gln Trp Leu Thr Asp Thr Glu Arg His Leu Leu
                 405                 410                 415    
 Ala Ser Lys Pro Leu Gly Gly Leu Pro Glu Thr Ala Lys Glu Gln Leu
             420                 425                 430        
 Asn Val His Met Glu Val Cys Ala Ala Phe Glu Ala Lys Glu Glu Thr
         435                 440                 445            
 Tyr Lys Ser Leu Met Gln Lys Gly Gln Gln Met Leu Ala Arg Cys Pro
     450                 455                 460                
 Lys Ser Ala Glu Thr Asn Ile Asp Gln Asp Ile Asn Asn Leu Lys Lys
 465                 470                 475                 480
 Lys Trp Glu Ser Val Glu Thr Lys Leu Asn Glu Arg Lys Thr Lys Leu
                 485                 490                 495    
 Glu Glu Ala Leu Asn Leu Ala Met Glu Phe His Asn Ser Leu Gln Asp
             500                 505                 510        
 Phe Ile Asn Trp Leu Thr Gln Ala Glu Gln Thr Leu Asn Val Ala Ser
         515                 520                 525            
 Arg Pro Ser Leu Ile Leu Asp Thr Val Leu Phe Gln Ile Asp Glu His
     530                 535                 540                
 Lys Val Phe Ala Asn Glu Val Asn Ser His Arg Glu Gln Ile Ile Glu
 545                 550                 555                 560
 Leu Asp Lys Thr Gly Thr His Leu Lys Tyr Phe Ser Gln Lys Gln Asp
                 565                 570                 575    
 Val Val Leu Ile Lys Asn Leu Leu Ile Ser Val Gln Ser Arg Trp Glu
             580                 585                 590        
 Lys Val Val Gln Arg Leu Val Glu Arg Gly Arg Ser Leu Asp Asp Ala
         595                 600                 605            
 Arg Lys Arg Ala Lys Gln Phe His Glu Ala Trp Ser Lys Leu Met Glu
     610                 615                 620                
 Trp Leu Glu Glu Ser Glu Lys Ser Leu Asp Ser Glu Leu Glu Ile Ala
 625                 630                 635                 640
 Asn Asp Pro Asp Lys Ile Lys Thr Gln Leu Ala Gln His Lys Glu Phe
                 645                 650                 655    
 Gln Lys Ser Leu Gly Ala Lys His Ser Val Tyr Asp Thr Thr Asn Arg
             660                 665                 670        
 Thr Gly Arg Ser Leu Lys Glu Lys Thr Ser Leu Ala Asp Asp Asn Leu
         675                 680                 685            
 Lys Leu Asp Asp Met Leu Ser Glu Leu Arg Asp Lys Trp Asp Thr Ile
     690                 695                 700                
 Cys Gly Lys Ser Val Glu Arg Gln Asn Lys Leu Glu Glu Ala Leu Leu
 705                 710                 715                 720
 Phe Ser Gly Gln Phe Thr Asp Ala Leu Gln Ala Leu Ile Asp Trp Leu
                 725                 730                 735    
 Tyr Arg Val Glu Pro Gln Leu Ala Glu Asp Gln Pro Val His Gly Asp
             740                 745                 750        
 Ile Asp Leu Val Met Asn Leu Ile Asp Asn His Lys Ala Phe Gln Lys
         755                 760                 765            
 Glu Leu Gly Lys Arg Thr Ser Ser Val Gln Ala Leu Lys Arg Ser Ala
     770                 775                 780                
 Arg Glu Leu Ile Glu Gly Ser Arg Asp Asp Ser Ser Trp Val Lys Val
 785                 790                 795                 800
 Gln Met Gln Glu Leu Ser Thr Arg Trp Glu Thr Val Cys Ala Leu Ser
                 805                 810                 815    
 Ile Ser Lys Gln Thr Arg Leu Glu Ala Ala Leu Arg Gln Ala Glu Glu
             820                 825                 830        
 Phe His Ser Val Val His Ala Leu Leu Glu Trp Leu Ala Glu Ala Glu
         835                 840                 845            
 Gln Thr Leu Arg Phe His Gly Val Leu Pro Asp Asp Glu Asp Ala Leu
     850                 855                 860                
 Arg Thr Leu Ile Asp Gln His Lys Glu Phe Met Lys Lys Leu Glu Glu
 865                 870                 875                 880
 Lys Arg Ala Glu Leu Asn Lys Ala Thr Thr Met Gly Asp Thr Val Leu
                 885                 890                 895    
 Ala Ile Cys His Pro Asp Ser Ile Thr Thr Ile Lys His Trp Ile Thr
             900                 905                 910        
 Ile Ile Arg Ala Arg Phe Glu Glu Val Leu Ala Trp Ala Lys Gln His
         915                 920                 925            
 Gln Gln Arg Leu Ala Ser Ala Leu Ala Gly Leu Ile Ala Lys Gln Glu
     930                 935                 940                
 Leu Leu Glu Ala Leu Leu Ala Trp Leu Gln Trp Ala Glu Thr Thr Leu
 945                 950                 955                 960
 Thr Asp Lys Asp Lys Glu Val Ile Pro Gln Glu Ile Glu Glu Val Lys
                 965                 970                 975    
 Ala Leu Ile Ala Glu His Gln Thr Phe Met Glu Glu Met Thr Arg Lys
             980                 985                 990        
 Gln Pro Asp Val Asp Lys Val Thr Lys Thr Tyr Lys Arg Arg Ala Ala
         995                1000                1005            
 Asp Pro Ser Ser Leu Gln Ser His Ile Pro Val Leu Asp Lys Gly Arg
    1010                1015                1020                
 Ala Gly Arg Lys Arg Phe Pro Ala Ser Ser Leu Tyr Pro Ser Gly Ser
1025                1030                1035                1040
 Gln Thr Gln Ile Glu Thr Lys Asn Pro Arg Val Asn Leu Leu Val Ser
                1045                1050                1055    
 Lys Trp Gln Gln Val Trp Leu Leu Ala Leu Glu Arg Arg Arg Lys Leu
            1060                1065                1070        
 Asn Asp Ala Leu Asp Arg Leu Glu Glu Leu Arg Glu Phe Ala Asn Phe
        1075                1080                1085            
 Asp Phe Asp Ile Trp Arg Lys Lys Tyr Met Arg Trp Met Asn His Lys
    1090                1095                1100                
 Lys Ser Arg Val Met Asp Phe Phe Arg Arg Ile Asp Lys Asp Gln Asp
1105                1110                1115                1120
 Gly Lys Ile Thr Arg Gln Glu Phe Ile Asp Gly Ile Leu Ser Ser Lys
                1125                1130                1135    
 Phe Pro Thr Ser Arg Leu Glu Met Ser Ala Val Ala Asp Ile Phe Asp
            1140                1145                1150        
 Arg Asp Gly Asp Gly Tyr Ile Asp Tyr Tyr Glu Phe Val Ala Ala Leu
        1155                1160                1165            
 His Pro Asn Lys Asp Ala Tyr Lys Pro Ile Thr Asp Ala Asp Lys Ile
    1170                1175                1180                
 Glu Asp Glu Val Thr Arg Gln Val Ala Lys Cys Lys Cys Ala Lys Arg
1185                1190                1195                1200
 Phe Gln Val Glu Gln Ile Gly Asp Asn Lys Tyr Arg Phe Phe Leu Gly
                1205                1210                1215    
 Asn Gln Phe Gly Asp Ser Gln Gln Leu Arg Leu Val Arg Ile Leu Arg
            1220                1225                1230        
 Ser Thr Val Met Val Arg Val Gly Gly Gly Trp Met Ala Leu Asp Glu
        1235                1240                1245            
 Phe Leu Val Lys Asn Asp Pro Cys Arg Ala Lys Gly Arg Thr Asn Met
    1250                1255                1260                
 Glu Leu Arg Glu Lys Phe Ile Leu Ala Asp Gly Ala Ser Gln Gly Met
1265                1270                1275                1280
 Ala Ala Phe Arg Pro Arg Gly Arg Arg Ser Arg Pro Ser Ser Arg Gly
                1285                1290                1295    
 Ala Ser Pro Asn Arg Ser Thr Ser Val Ser Ser Gln Ala Ala Gln Ala
            1300                1305                1310        
 Ala Ser Pro Gln Val Pro Ala Thr Thr Thr Pro Lys Ile Leu His Pro
        1315                1320                1325            
 Leu Thr Arg Asn Tyr Gly Lys Pro Trp Leu Thr Asn Ser Lys Met Ser
    1330                1335                1340                
 Thr Pro Cys Lys Ala Ala Glu Cys Ser Asp Phe Pro Val Pro Ser Ala
1345                1350                1355                1360
 Glu Gly Thr Pro Ile Gln Gly Ser Lys Leu Arg Leu Pro Gly Tyr Leu
                1365                1370                1375    
 Ser Gly Lys Gly Phe His Ser Gly Glu Asp Ser Gly Leu Ile Thr Thr
            1380                1385                1390        
 Ala Ala Ala Arg Val Arg Thr Gln Phe Ala Asp Ser Lys Lys Thr Pro
        1395                1400                1405            
 Ser Arg Pro Gly Ser Arg Ala Gly Ser Lys Ala Gly Ser Arg Ala Ser
    1410                1415                1420                
 Ser Arg Arg Gly Ser Asp Ala Ser Asp Phe Asp Ile Ser Glu Ile Gln
1425                1430                1435                1440
 Ser Val Cys Ser Asp Val Glu Thr Val Pro Gln Thr His Arg Pro Thr
                1445                1450                1455    
 Pro Arg Ala Gly Ser Arg Pro Ser Thr Ala Lys Pro Ser Lys Ile Pro
            1460                1465                1470        
 Thr Pro Gln Arg Lys Ser Pro Ala Ser Lys Leu Asp Lys Ser Ser Lys
        1475                1480                1485            
 Arg
    



      <210> 949
      <211> 640
      <212> PRT
      <213> Homo sapiens


      <400> 949
 Met Ser Ser Phe Asn Ala Phe Glu Ser Lys Gln Gln Ser Ala Asp Gln
   1               5                  10                  15    
 Asp Ala Glu Ser Ala Tyr Thr Glu Pro Tyr Lys Val Cys Pro Ile Ser
              20                  25                  30        
 Ser Ala Ala Pro Lys Glu Asp Leu Thr Ser Asp Glu Glu Gln Arg Ser
          35                  40                  45            
 Ser Glu Glu Glu Asp Ser Ala Ser Arg Asp Pro Ser Val Thr His Lys
      50                  55                  60                
 Val Glu Gly Gln Ser Arg Ala Leu Val Ile Ala Gln Glu Leu Leu Ser
  65                  70                  75                  80
 Ser Glu Lys Ala Tyr Val Glu Met Leu Gln His Leu Asn Leu Asp Phe
                  85                  90                  95    
 His Gly Ala Val Met Arg Ala Leu Asp Asp Met Asp His Glu Gly Arg
             100                 105                 110        
 Asp Thr Leu Ala Arg Glu Glu Leu Arg Gln Gly Leu Ser Glu Leu Pro
         115                 120                 125            
 Ala Ile His Asp Leu His Gln Gly Ile Leu Glu Glu Leu Glu Glu Arg
     130                 135                 140                
 Leu Ser Asn Trp Glu Ser Gln Gln Lys Val Ala Asp Val Phe Leu Ala
 145                 150                 155                 160
 Arg Glu Gln Gly Phe Asp His His Ala Thr His Ile Leu Gln Phe Asp
                 165                 170                 175    
 Arg Tyr Leu Gly Leu Leu Ser Glu Asn Cys Leu His Ser Pro Arg Leu
             180                 185                 190        
 Ala Ala Ala Val Arg Glu Phe Glu Gln Ser Val Gln Gly Gly Ser Gln
         195                 200                 205            
 Thr Ala Lys His Arg Leu Leu Arg Val Val Gln Arg Leu Phe Gln Tyr
     210                 215                 220                
 Gln Val Leu Leu Thr Asp Tyr Leu Asn Asn Leu Cys Pro Asp Ser Ala
 225                 230                 235                 240
 Glu Tyr Asp Asn Thr Gln Gly Ala Leu Ser Leu Ile Ser Lys Val Thr
                 245                 250                 255    
 Asp Arg Ala Asn Asp Ser Met Glu Gln Gly Glu Asn Leu Gln Lys Leu
             260                 265                 270        
 Val His Ile Glu His Ser Val Arg Gly Gln Gly Asp Leu Leu Gln Pro
         275                 280                 285            
 Gly Arg Glu Phe Leu Lys Glu Gly Thr Leu Met Lys Val Thr Gly Lys
     290                 295                 300                
 Asn Arg Arg Pro Arg His Leu Phe Leu Met Asn Asp Val Leu Leu Tyr
 305                 310                 315                 320
 Thr Tyr Pro Gln Lys Asp Gly Lys Tyr Arg Leu Lys Asn Thr Leu Ala
                 325                 330                 335    
 Val Ala Asn Met Lys Val Ser Arg Pro Val Met Glu Lys Val Pro Tyr
             340                 345                 350        
 Ala Leu Lys Ile Glu Thr Ser Glu Ser Cys Leu Met Leu Ser Ala Ser
         355                 360                 365            
 Ser Cys Ala Glu Arg Asp Glu Trp Tyr Gly Cys Leu Ser Arg Ala Leu
     370                 375                 380                
 Pro Glu Asp Tyr Lys Ala Gln Ala Leu Ala Ala Phe His His Ser Val
 385                 390                 395                 400
 Glu Ile Arg Glu Arg Leu Gly Val Ser Leu Gly Glu Arg Pro Pro Thr
                 405                 410                 415    
 Leu Val Pro Val Thr His Val Met Met Cys Met Asn Cys Gly Cys Asp
             420                 425                 430        
 Phe Ser Leu Thr Leu Arg Arg His His Cys His Ala Cys Gly Lys Ile
         435                 440                 445            
 Val Cys Arg Asn Cys Ser Arg Asn Lys Tyr Pro Leu Lys Tyr Leu Lys
     450                 455                 460                
 Asp Arg Met Ala Lys Val Cys Asp Gly Cys Phe Gly Glu Leu Lys Lys
 465                 470                 475                 480
 Arg Gly Arg Ala Val Pro Gly Leu Met Arg Glu Arg Pro Val Ser Met
                 485                 490                 495    
 Ser Phe Pro Leu Ser Ser Pro Arg Phe Ser Gly Ser Ala Phe Ser Ser
             500                 505                 510        
 Val Phe Gln Ser Ile Asn Pro Ser Thr Phe Lys Lys Gln Lys Lys Val
         515                 520                 525            
 Pro Ser Ala Leu Thr Glu Val Ala Ala Ser Gly Glu Gly Ser Ala Ile
     530                 535                 540                
 Ser Gly Tyr Leu Ser Arg Cys Lys Arg Gly Lys Arg His Trp Lys Lys
 545                 550                 555                 560
 Leu Trp Phe Val Ile Lys Gly Lys Val Leu Tyr Thr Tyr Met Ala Ser
                 565                 570                 575    
 Glu Asp Lys Val Ala Leu Glu Ser Met Pro Leu Leu Gly Phe Thr Ile
             580                 585                 590        
 Ala Pro Glu Lys Gly Glu Gly Ser Ser Glu Val Gly Pro Ile Phe His
         595                 600                 605            
 Leu Tyr His Lys Lys Thr Leu Phe Tyr Ser Phe Lys Ala Glu Asp Thr
     610                 615                 620                
 Asn Ser Ala Gln Arg Trp Ile Glu Ala Met Glu Asp Ala Ser Val Leu
 625                 630                 635                 640





      <210> 950
      <211> 1100
      <212> PRT
      <213> Homo sapiens


      <400> 950
 Met Lys Glu Trp Lys Ser Lys Met Glu Ile Ser Glu Glu Lys Lys Ser
   1               5                  10                  15    
 Ala Arg Ala Ala Ser Glu Lys Leu Gln Arg Gln Ile Thr Gln Glu Cys
              20                  25                  30        
 Glu Leu Val Glu Thr Ser Asn Ser Glu Asp Arg Leu Leu Lys His Trp
          35                  40                  45            
 Val Ser Pro Leu Lys Asp Ala Met Arg His Leu Pro Ser Gln Glu Ser
      50                  55                  60                
 Gly Ile Arg Glu Met His Ile Ile Pro Gln Lys Ala Ile Val Gly Glu
  65                  70                  75                  80
 Ile Gly His Gly Cys Asn Glu Gly Glu Lys Ile Leu Ser Ala Gly Glu
                  85                  90                  95    
 Ser Ser His Arg Tyr Glu Val Ser Gly Gln Asn Phe Lys Gln Lys Ser
             100                 105                 110        
 Gly Leu Thr Glu His Gln Lys Ile His Asn Ile Asn Lys Thr Tyr Glu
         115                 120                 125            
 Cys Lys Glu Cys Glu Lys Thr Phe Asn Arg Ser Ser Asn Leu Ile Ile
     130                 135                 140                
 His Gln Arg Ile His Thr Gly Asn Lys Pro Tyr Val Cys Asn Glu Cys
 145                 150                 155                 160
 Gly Lys Asp Ser Asn Gln Ser Ser Asn Leu Ile Ile His Gln Arg Ile
                 165                 170                 175    
 His Thr Gly Lys Lys Pro Tyr Ile Cys His Glu Cys Gly Lys Asp Phe
             180                 185                 190        
 Asn Gln Ser Ser Asn Leu Val Arg His Lys Gln Ile His Ser Gly Gly
         195                 200                 205            
 Asn Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Lys Gly Ser Ser
     210                 215                 220                
 Asn Leu Val Leu His Gln Arg Ile His Ser Arg Gly Lys Pro Tyr Leu
 225                 230                 235                 240
 Cys Asn Lys Cys Gly Lys Ala Phe Ser Gln Ser Thr Asp Leu Ile Ile
                 245                 250                 255    
 His His Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Tyr Asp Cys
             260                 265                 270        
 Gly Gln Met Phe Ser Gln Ser Ser His Leu Val Pro His Gln Arg Ile
         275                 280                 285            
 His Thr Gly Glu Lys Pro Leu Lys Cys Asn Glu Cys Glu Lys Ala Phe
     290                 295                 300                
 Arg Gln His Ser His Leu Thr Glu His Gln Arg Leu His Ser Gly Glu
 305                 310                 315                 320
 Lys Pro Tyr Glu Cys His Arg Cys Gly Lys Thr Phe Ser Gly Arg Thr
                 325                 330                 335    
 Ala Phe Leu Lys His Gln Arg Leu His Ala Gly Glu Lys Ile Glu Glu
             340                 345                 350        
 Cys Glu Lys Thr Phe Ser Lys Asp Glu Glu Leu Arg Glu Glu Gln Arg
         355                 360                 365            
 Ile His Gln Glu Glu Lys Ala Tyr Trp Cys Asn Gln Cys Gly Arg Asn
     370                 375                 380                
 Phe Gln Gly Thr Ser Asp Leu Ile Arg His Gln Val Thr His Thr Gly
 385                 390                 395                 400
 Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Thr Phe Asn Gln Ser
                 405                 410                 415    
 Ser Asp Leu Leu Arg His His Arg Ile His Ser Gly Glu Lys Pro Cys
             420                 425                 430        
 Val Cys Ser Lys Cys Gly Lys Ser Phe Arg Gly Ser Ser Asp Leu Ile
         435                 440                 445            
 Arg His His Arg Val His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Glu
     450                 455                 460                
 Cys Gly Lys Ala Phe Ser Gln Arg Ser His Leu Val Thr His Gln Lys
 465                 470                 475                 480
 Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Thr Glu Cys Gly Lys Ala
                 485                 490                 495    
 Phe Arg Arg Arg Ser Leu Leu Ile Gln His Arg Arg Ile His Ser Gly
             500                 505                 510        
 Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Leu Phe Ile Trp Arg
         515                 520                 525            
 Thr Ala Phe Leu Lys His Gln Ser Leu His Thr Gly Glu Lys Leu Glu
     530                 535                 540                
 Cys Glu Lys Thr Phe Ser Gln Asp Glu Glu Leu Arg Gly Glu Gln Lys
 545                 550                 555                 560
 Ile His Gln Glu Ala Lys Ala Tyr Trp Cys Asn Gln Cys Gly Arg Ala
                 565                 570                 575    
 Phe Gln Gly Ser Ser Asp Leu Ile Arg His Gln Val Thr His Thr Arg
             580                 585                 590        
 Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Thr Phe Asn Gln Ser
         595                 600                 605            
 Ser Asp Leu Leu Arg His His Arg Ile His Ser Gly Glu Lys Pro Tyr
     610                 615                 620                
 Val Cys Asn Lys Cys Gly Lys Ser Phe Arg Gly Ser Ser Asp Leu Ile
 625                 630                 635                 640
 Lys His His Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Glu
                 645                 650                 655    
 Cys Gly Lys Ala Phe Ser Gln Arg Ser His Leu Ala Thr His Gln Lys
             660                 665                 670        
 Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Ser Glu Cys Gly Asn Ala
         675                 680                 685            
 Phe Arg Arg Arg Ser Leu Leu Ile Gln His Arg Arg Leu His Ser Gly
     690                 695                 700                
 Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Leu Phe Met Trp His
 705                 710                 715                 720
 Thr Ala Phe Leu Lys His Gln Arg Leu His Ala Gly Glu Lys Leu Glu
                 725                 730                 735    
 Glu Cys Glu Lys Thr Phe Ser Lys Asp Glu Glu Leu Arg Lys Glu Gln
             740                 745                 750        
 Arg Thr His Gln Glu Lys Lys Val Tyr Trp Cys Asn Gln Cys Ser Arg
         755                 760                 765            
 Thr Phe Gln Gly Ser Ser Asp Leu Ile Arg His Gln Ser Ser Asp Leu
     770                 775                 780                
 Leu Arg His His Arg Ile His Ser Gly Glu Lys Pro Tyr Val Cys Asn
 785                 790                 795                 800
 Lys Cys Gly Glu Ser Phe Arg Ser Ser Ser Asp Leu Ile Lys His His
                 805                 810                 815    
 Arg Val His Thr Gly Glu Lys Pro His Glu Cys Ser Glu Cys Gly Lys
             820                 825                 830        
 Val Phe Ser Gln Arg Ser His Leu Val Thr His Gln Lys Ile His Thr
         835                 840                 845            
 Gly Glu Lys Pro Tyr Gln Cys Thr Glu Cys Glu Lys Ala Phe Arg Arg
     850                 855                 860                
 Arg Ser Leu Leu Ile Gln Arg Arg Arg Ile His Ser Gly Glu Lys Pro
 865                 870                 875                 880
 Tyr Glu Cys Lys Glu Cys Gly Lys Leu Phe Met Trp His Thr Ala Phe
                 885                 890                 895    
 Leu Lys His Gln Arg Leu His Ala Gly Glu Lys Leu Glu Glu Cys Glu
             900                 905                 910        
 Lys Thr Phe Ser Lys Asp Glu Glu Leu Arg Gly Glu Gln Lys Ile His
         915                 920                 925            
 Gln Glu Glu Lys Ala Tyr Trp Cys Asn Gln Cys Gly Arg Ala Phe Gln
     930                 935                 940                
 Gly Ser Ser Asp Leu Ile Gly His Gln Val Thr His Thr Gly Glu Lys
 945                 950                 955                 960
 Pro Tyr Glu Cys Lys Glu Cys Gly Lys Thr Phe Asn Gln Ser Ser Asp
                 965                 970                 975    
 Leu Leu Arg His His Arg Ile His Ser Gly Glu Lys Pro Tyr Val Cys
             980                 985                 990        
 Asn Lys Cys Gly Lys Ser Phe Arg Gly Ser Ser Asp Leu Ile Arg His
         995                1000                1005            
 His Arg Val His Thr Gly Glu Lys Pro Tyr Glu Cys Pro Glu Cys Trp
    1010                1015                1020                
 Lys Ala Phe Ser Gln Asn Ser His Leu Val Ser His Gln Arg Ile His
1025                1030                1035                1040
 Thr Arg Glu Lys Pro Phe Glu Cys Ser Asn Cys Gly Lys Ala Phe Ser
                1045                1050                1055    
 Gly Trp Thr Ala Phe Leu Lys His Gln Lys Leu His Ile Gly Lys Glu
            1060                1065                1070        
 Phe Glu Asp Cys Lys Ser Leu Gln Thr Gly Pro Ile Leu Ile Gly Ser
        1075                1080                1085            
 Arg Asn Leu Met Asn Ala Val Lys Leu Gly Lys Val
    1090                1095                1100



      <210> 951
      <211> 718
      <212> PRT
      <213> Homo sapiens


      <400> 951
 Met His His Ala Leu Leu Gln Glu Val Asp Val Val Val Ala Pro Cys
   1               5                  10                  15    
 Gln Gly Leu Arg Pro Thr Val Asp Val Leu Gly Asp Leu Val Asn Asp
              20                  25                  30        
 Phe Leu Pro Val Ile Thr Tyr Ala Leu His Lys Asp Glu Leu Ser Glu
          35                  40                  45            
 Arg Asp Glu Gln Glu Leu Gln Glu Ile Arg Lys Tyr Phe Ser Phe Pro
      50                  55                  60                
 Val Phe Phe Phe Lys Val Pro Lys Leu Gly Ser Glu Ile Ile Asp Ser
  65                  70                  75                  80
 Ser Thr Arg Arg Met Glu Ser Glu Arg Ser Pro Leu Tyr Arg Gln Leu
                  85                  90                  95    
 Ile Asp Leu Gly Tyr Leu Ser Ser Ser His Trp Asn Cys Gly Ala Pro
             100                 105                 110        
 Gly Gln Asp Thr Lys Ala Gln Ser Met Leu Val Glu Gln Ser Glu Lys
         115                 120                 125            
 Leu Arg His Leu Ser Thr Phe Ser His Gln Val Leu Gln Thr Arg Leu
     130                 135                 140                
 Val Asp Ala Ala Lys Ala Leu Asn Leu Val His Cys His Cys Leu Asp
 145                 150                 155                 160
 Ile Phe Ile Asn Gln Ala Phe Asp Met Gln Arg Asp Leu Gln Ile Thr
                 165                 170                 175    
 Pro Lys Arg Leu Glu Tyr Thr Arg Lys Lys Glu Asn Glu Leu Tyr Glu
             180                 185                 190        
 Ser Leu Met Asn Ile Ala Asn Arg Lys Gln Glu Glu Met Lys Asp Met
         195                 200                 205            
 Ile Val Glu Thr Leu Asn Thr Met Lys Glu Glu Leu Leu Asp Asp Ala
     210                 215                 220                
 Thr Asn Met Glu Phe Lys Asp Val Ile Val Pro Glu Ser Gly Glu Pro
 225                 230                 235                 240
 Val Gly Thr Arg Glu Ile Lys Cys Cys Ile Arg Gln Ile Gln Glu Leu
                 245                 250                 255    
 Ile Ile Ser Arg Leu Asn Gln Ala Val Ala Asn Lys Leu Ile Ser Ser
             260                 265                 270        
 Val Asp Tyr Leu Arg Glu Ser Phe Val Gly Thr Leu Glu Arg Cys Leu
         275                 280                 285            
 Gln Ser Leu Glu Lys Ser Gln Asp Val Ser Val His Ile Thr Ser Asn
     290                 295                 300                
 Tyr Leu Lys Gln Ile Leu Asn Ala Ala Tyr His Val Glu Val Thr Phe
 305                 310                 315                 320
 His Ser Gly Ser Ser Val Thr Arg Met Leu Trp Glu Gln Ile Lys Gln
                 325                 330                 335    
 Ile Ile Gln Arg Ile Thr Trp Val Ser Pro Pro Ala Ile Thr Leu Glu
             340                 345                 350        
 Trp Lys Arg Lys Val Ala Gln Glu Ala Ile Glu Ser Leu Ser Ala Ser
         355                 360                 365            
 Lys Leu Ala Lys Ser Ile Cys Ser Gln Phe Arg Thr Arg Leu Asn Ser
     370                 375                 380                
 Ser His Glu Ala Phe Ala Ala Ser Leu Arg Gln Leu Glu Ala Gly His
 385                 390                 395                 400
 Ser Gly Arg Leu Glu Lys Thr Glu Asp Leu Trp Leu Arg Val Arg Lys
                 405                 410                 415    
 Asp His Ala Pro Arg Leu Ala Arg Leu Ser Leu Glu Ser Arg Ser Leu
             420                 425                 430        
 Gln Asp Val Leu Leu His Arg Lys Pro Lys Leu Gly Gln Glu Leu Gly
         435                 440                 445            
 Arg Gly Gln Tyr Gly Val Val Tyr Leu Cys Asp Asn Trp Gly Gly His
     450                 455                 460                
 Phe Pro Cys Ala Leu Lys Ser Val Val Pro Pro Asp Glu Lys His Trp
 465                 470                 475                 480
 Asn Asp Leu Ala Leu Glu Phe His Tyr Met Arg Ser Leu Pro Lys His
                 485                 490                 495    
 Glu Arg Leu Val Asp Leu His Gly Ser Val Ile Asp Tyr Asn Tyr Gly
             500                 505                 510        
 Gly Gly Ser Ser Ile Ala Val Leu Leu Ile Met Glu Arg Leu His Arg
         515                 520                 525            
 Asp Leu Tyr Thr Gly Leu Lys Ala Gly Leu Thr Leu Glu Thr Arg Leu
     530                 535                 540                
 Gln Ile Ala Leu Asp Val Val Glu Gly Ile Arg Phe Leu His Ser Gln
 545                 550                 555                 560
 Gly Leu Val His Arg Asp Ile Lys Leu Lys Asn Val Leu Leu Asp Lys
                 565                 570                 575    
 Gln Asn Arg Ala Lys Ile Thr Asp Leu Gly Phe Cys Lys Pro Glu Ala
             580                 585                 590        
 Met Met Ser Gly Ser Ile Val Gly Thr Pro Ile His Met Ala Pro Glu
         595                 600                 605            
 Leu Phe Thr Gly Lys Tyr Asp Asn Ser Val Asp Val Tyr Ala Phe Gly
     610                 615                 620                
 Ile Leu Phe Trp Tyr Ile Cys Ser Gly Ser Val Lys Leu Pro Glu Ala
 625                 630                 635                 640
 Phe Glu Arg Cys Ala Ser Lys Asp His Leu Trp Asn Asn Val Arg Arg
                 645                 650                 655    
 Gly Ala Arg Pro Glu Arg Leu Pro Val Phe Asp Glu Glu Cys Trp Gln
             660                 665                 670        
 Leu Met Glu Ala Cys Trp Asp Gly Asp Pro Leu Lys Arg Pro Leu Leu
         675                 680                 685            
 Gly Ile Val Gln Pro Met Leu Gln Gly Ile Met Asn Arg Leu Cys Lys
     690                 695                 700                
 Ser Asn Ser Glu Gln Pro Asn Arg Gly Leu Asp Asp Ser Thr
 705                 710                 715            



      <210> 952
      <211> 183
      <212> PRT
      <213> Homo sapiens


      <400> 952
 Met Asp Asn Cys Leu Ala Ala Ala Ala Leu Asn Gly Val Asp Arg Arg
   1               5                  10                  15    
 Ser Leu Gln Arg Ser Ala Arg Leu Ala Leu Glu Val Leu Glu Arg Ala
              20                  25                  30        
 Lys Arg Arg Ala Val Asp Trp His Ala Leu Glu Arg Pro Lys Gly Cys
          35                  40                  45            
 Met Gly Val Leu Ala Arg Glu Ala Pro His Leu Glu Lys Gln Pro Ala
      50                  55                  60                
 Ala Gly Pro Gln Arg Val Leu Pro Gly Glu Lys Tyr Tyr Ser Ser Val
  65                  70                  75                  80
 Pro Glu Glu Gly Gly Ala Thr His Val Tyr Arg Tyr His Arg Gly Glu
                  85                  90                  95    
 Ser Lys Leu His Met Cys Leu Asp Ile Gly Asn Gly Gln Arg Lys Asp
             100                 105                 110        
 Arg Lys Lys Thr Ser Leu Gly Pro Gly Gly Ser Tyr Gln Ile Ser Glu
         115                 120                 125            
 His Ala Pro Glu Ala Ser Gln Pro Ala Glu Asn Ile Ser Lys Asp Leu
     130                 135                 140                
 Tyr Ile Glu Val Tyr Pro Gly Thr Tyr Ser Val Thr Val Gly Ser Asn
 145                 150                 155                 160
 Asp Leu Thr Lys Lys Thr His Val Val Ala Val Asp Ser Gly Gln Ser
                 165                 170                 175    
 Val Asp Leu Val Phe Pro Val
             180            



      <210> 953
      <211> 276
      <212> PRT
      <213> Homo sapiens


      <400> 953
 Met Ser Lys Ser Glu Ser Leu Lys Glu Pro Glu Gln Leu Gln Lys Leu
   1               5                  10                  15    
 Leu Thr Gly Gly Leu Ser Ile Glu Ala Thr Asn Glu Ser Leu Arg Ser
              20                  25                  30        
 His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Leu Arg Asp
          35                  40                  45            
 Pro Asn Thr Lys Cys Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr
      50                  55                  60                
 Val Glu Glu Val Asp Ala Ala Thr Asn Ala Arg Pro His Lys Val Asp
  65                  70                  75                  80
 Gly Arg Val Val Glu Thr Lys Arg Ala Val Ser Arg Glu Asp Ser Gln
                  85                  90                  95    
 Arg Pro Gly Ala His Leu Thr Val Lys Lys Phe Gly Lys Met Glu Val
             100                 105                 110        
 Ile Glu Ile Met Thr Asp His Gly Ser Gly Lys Lys Arg Asp Phe Ala
         115                 120                 125            
 Phe Val Thr Phe Asp Asp His Asp Ser Val Asp Lys Thr Val Ile Gln
     130                 135                 140                
 Lys Tyr His Ile Val Asn Gly His Asn Cys Glu Val Arg Lys Ala Leu
 145                 150                 155                 160
 Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser Gln Arg Gly Arg Thr
                 165                 170                 175    
 Gly Ser Gly Asn Phe Gly Gly Gly Cys Arg Gly Gly Phe Gly Gly Asn
             180                 185                 190        
 Asp Asn Phe Gly His Gly Gly Asp Phe Ser Gly His Ser Gly Phe Gly
         195                 200                 205            
 Gly Ser Gln Gly Gly Gly Gly Tyr Asp Gly Ser Gly Asp Gly Tyr Asn
     210                 215                 220                
 Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Ser Gly Gly Ser Tyr Ser
 225                 230                 235                 240
 Asp Phe Gly Asn Tyr Ser Asn Gln Ser Ser Asp Phe Gly Pro Lys Lys
                 245                 250                 255    
 Gly Glu Asn Phe Gly Gly Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly
             260                 265                 270        
 Gln Tyr Phe Ala
         275    



      <210> 954
      <211> 58
      <212> PRT
      <213> Homo sapiens


      <400> 954
 Met Ala Gly Pro Glu Ser Asp Ala Gln Tyr Gln Phe Thr Gly Ile Lys
   1               5                  10                  15    
 Lys Tyr Phe Asn Ser Tyr Thr Leu Thr Gly Arg Met Asn Cys Val Leu
              20                  25                  30        
 Val Thr Tyr Arg Ser Ile Ala Leu Ile Val Leu Tyr Phe Lys Leu Arg
          35                  40                  45            
 Ser Lys Lys Thr Pro Ala Met Lys Ala Thr
      50                  55            



      <210> 955
      <211> 881
      <212> PRT
      <213> Homo sapiens


      <400> 955
 Met Asn Tyr Pro Gly Arg Gly Ser Pro Arg Ser Pro Glu His Asn Gly
   1               5                  10                  15    
 Arg Gly Gly Gly Gly Gly Ala Trp Glu Leu Gly Ser Asp Ala Arg Pro
              20                  25                  30        
 Ala Phe Gly Gly Gly Val Cys Arg Leu Glu His Leu Pro Gly Gly Asp
          35                  40                  45            
 Pro Asp Asp Gly Asp Val Pro Leu Ala Leu Leu Arg Gly Glu Pro Gly
      50                  55                  60                
 Leu His Leu Ala Pro Gly Thr Asp Asp His Asn His His Leu Ala Leu
  65                  70                  75                  80
 Asp Pro Cys Leu Ser Asp Glu Asn Tyr Asp Phe Ser Ser Ala Glu Ser
                  85                  90                  95    
 Gly Ser Ser Leu Arg Tyr Tyr Ser Glu Gly Glu Ser Gly Gly Gly Gly
             100                 105                 110        
 Gly Gly Ser Ser Leu Ser Leu His Pro Pro Gln Gln Pro Pro Leu Val
         115                 120                 125            
 Pro Thr Asn Ser Gly Gly Gly Gly Ala Thr Gly Gly Ser Pro Gly Glu
     130                 135                 140                
 Arg Lys Arg Thr Arg Leu Gly Gly Pro Ala Ala Arg His Arg Tyr Glu
 145                 150                 155                 160
 Val Val Thr Glu Leu Gly Pro Glu Glu Val Arg Trp Phe Tyr Lys Glu
                 165                 170                 175    
 Asp Lys Lys Thr Trp Lys Pro Phe Ile Gly Tyr Asp Ser Leu Arg Ile
             180                 185                 190        
 Glu Leu Ala Phe Arg Thr Leu Leu Gln Thr Thr Gly Ala Arg Pro Gln
         195                 200                 205            
 Gly Gly Asp Arg Asp Gly Asp His Val Cys Ser Pro Thr Gly Pro Ala
     210                 215                 220                
 Ser Ser Ser Gly Glu Asp Asp Asp Glu Asp Arg Ala Cys Gly Phe Cys
 225                 230                 235                 240
 Gln Ser Thr Thr Gly His Glu Pro Glu Met Val Glu Leu Val Asn Ile
                 245                 250                 255    
 Glu Pro Val Cys Val Arg Gly Gly Leu Tyr Glu Val Asp Val Thr Gln
             260                 265                 270        
 Gly Glu Cys Tyr Pro Val Tyr Trp Asn Gln Ala Asp Lys Ile Pro Val
         275                 280                 285            
 Met Arg Gly Gln Trp Phe Ile Asp Gly Thr Trp Gln Pro Leu Glu Glu
     290                 295                 300                
 Glu Glu Ser Asn Leu Ile Glu Gln Glu His Leu Asn Cys Phe Arg Gly
 305                 310                 315                 320
 Gln Gln Met Gln Glu Asn Phe Asp Ile Glu Val Ser Lys Ser Ile Asp
                 325                 330                 335    
 Gly Lys Asp Gly Ser Gly Ile Asn Tyr Ser Ala Val His Ser Phe Lys
             340                 345                 350        
 Leu Ser Arg Asn His Val Asp Trp His Ser Val Asp Glu Val Tyr Leu
         355                 360                 365            
 Tyr Ser Asp Ala Thr Thr Ser Lys Ile Ala Arg Thr Val Thr Gln Lys
     370                 375                 380                
 Leu Gly Phe Ser Lys Ala Ser Ser Ser Gly Thr Arg Leu His Arg Gly
 385                 390                 395                 400
 Tyr Val Glu Glu Ala Thr Leu Glu Asp Lys Pro Ser Gln Thr Thr His
                 405                 410                 415    
 Ile Val Phe Val Val His Gly Ile Gly Gln Lys Met Asp Gln Gly Arg
             420                 425                 430        
 Ile Ile Lys Asn Thr Ala Met Met Arg Glu Ala Ala Arg Lys Ile Glu
         435                 440                 445            
 Glu Arg His Phe Ser Asn His Ala Thr His Val Glu Phe Leu Pro Val
     450                 455                 460                
 Glu Trp Arg Ser Lys Leu Thr Leu Asp Gly Asp Thr Val Asp Ser Ile
 465                 470                 475                 480
 Thr Pro Asp Lys Val Arg Gly Leu Arg Asp Met Leu Asn Ser Ser Ala
                 485                 490                 495    
 Met Asp Ile Met Tyr Tyr Thr Ser Pro Leu Tyr Arg Asp Glu Leu Val
             500                 505                 510        
 Lys Gly Leu Gln Gln Glu Leu Asn Arg Leu Tyr Ser Leu Phe Cys Ser
         515                 520                 525            
 Arg Asn Pro Asp Phe Glu Glu Lys Gly Gly Lys Val Ser Ile Val Ser
     530                 535                 540                
 His Ser Leu Gly Cys Val Ile Thr Tyr Asp Ile Met Thr Gly Trp Asn
 545                 550                 555                 560
 Pro Val Arg Leu Tyr Glu Gln Leu Leu Gln Lys Glu Glu Glu Leu Pro
                 565                 570                 575    
 Asp Glu Arg Trp Met Ser Tyr Glu Glu Arg His Leu Leu Asp Glu Leu
             580                 585                 590        
 Tyr Ile Thr Lys Arg Arg Leu Lys Glu Ile Glu Glu Arg Leu His Gly
         595                 600                 605            
 Leu Lys Ala Ser Ser Met Thr Gln Thr Pro Ala Leu Lys Phe Lys Val
     610                 615                 620                
 Glu Asn Phe Phe Cys Met Gly Ser Pro Leu Ala Val Phe Leu Ala Leu
 625                 630                 635                 640
 Arg Gly Ile Arg Pro Gly Asn Thr Gly Ser Gln Asp His Ile Leu Pro
                 645                 650                 655    
 Arg Glu Ile Cys Asn Arg Leu Leu Asn Ile Phe His Pro Thr Asp Pro
             660                 665                 670        
 Val Ala Tyr Arg Leu Glu Pro Leu Ile Leu Lys His Tyr Ser Asn Ile
         675                 680                 685            
 Ser Pro Val Gln Ile His Trp Tyr Asn Thr Ser Asn Pro Leu Pro Tyr
     690                 695                 700                
 Glu His Met Lys Pro Ser Phe Leu Asn Pro Ala Lys Glu Pro Thr Ser
 705                 710                 715                 720
 Val Ser Glu Asn Glu Gly Ile Ser Thr Ile Pro Ser Pro Val Thr Ser
                 725                 730                 735    
 Pro Val Leu Ser Arg Arg His Tyr Gly Glu Ser Ile Thr Asn Ile Gly
             740                 745                 750        
 Lys Ala Ser Ile Leu Gly Ala Ala Ser Ile Gly Lys Gly Leu Gly Gly
         755                 760                 765            
 Met Leu Phe Ser Arg Phe Gly Arg Ser Ser Thr Thr Gln Ser Ser Glu
     770                 775                 780                
 Thr Ser Lys Asp Ser Met Glu Asp Glu Lys Lys Pro Val Ala Ser Pro
 785                 790                 795                 800
 Ser Ala Thr Thr Val Gly Thr Gln Thr Leu Pro His Ser Ser Ser Gly
                 805                 810                 815    
 Phe Leu Asp Ser Ala Leu Glu Leu Asp His Arg Ile Asp Phe Glu Leu
             820                 825                 830        
 Arg Glu Gly Leu Val Glu Ser Arg Tyr Trp Ser Ala Val Thr Ser His
         835                 840                 845            
 Thr Ala Tyr Trp Ser Ser Leu Asp Val Ala Leu Phe Leu Leu Thr Phe
     850                 855                 860                
 Met Tyr Lys His Glu His Asp Asp Asp Ala Lys Pro Asn Leu Asp Pro
 865                 870                 875                 880
 Ile
    



      <210> 956
      <211> 769
      <212> PRT
      <213> Homo sapiens


      <400> 956
 Met Ala Ala Leu Asp Val Asp Ser Gly Gly Gly Gly Gly Gly Gly Gly
   1               5                  10                  15    
 Gly His Gly Glu Tyr Leu Gln Gln Gln Gln Gln His Gly Asn Gly Ala
              20                  25                  30        
 Val Ala Ala Ala Ala Ala Ala Gln Asp Thr Gln Pro Ser Pro Leu Ala
          35                  40                  45            
 Leu Leu Ala Ala Thr Cys Ser Lys Ile Gly Pro Pro Ser Pro Gly Asp
      50                  55                  60                
 Asp Glu Glu Glu Ala Ala Ala Ala Ala Gly Ala Pro Ala Ala Ala Gly
  65                  70                  75                  80
 Ala Thr Gly Asp Leu Ala Ser Ala Gln Leu Gly Gly Ala Pro Asn Arg
                  85                  90                  95    
 Trp Glu Val Leu Ser Ala Thr Pro Thr Thr Ile Lys Asp Glu Ala Gly
             100                 105                 110        
 Asn Leu Val Gln Ile Pro Ser Ala Ala Thr Ser Ser Gly Gln Tyr Val
         115                 120                 125            
 Leu Pro Leu Gln Asn Leu Gln Asn Gln Gln Ile Phe Ser Val Ala Pro
     130                 135                 140                
 Gly Ser Asp Ser Ser Asn Gly Thr Val Ser Ser Val Gln Tyr Gln Val
 145                 150                 155                 160
 Ile Pro Gln Ile Gln Ser Ala Asp Gly Gln Gln Val Gln Ile Gly Phe
                 165                 170                 175    
 Thr Gly Ser Ser Asp Asn Gly Gly Ile Asn Gln Glu Ser Ser Gln Ile
             180                 185                 190        
 Gln Ile Ile Pro Gly Ser Asn Gln Thr Leu Leu Ala Ser Gly Thr Pro
         195                 200                 205            
 Ser Ala Asn Ile Gln Asn Leu Ile Pro Gln Thr Gly Gln Val Gln Val
     210                 215                 220                
 Gln Gly Val Ala Ile Gly Gly Ser Ser Phe Pro Gly Gln Thr Gln Val
 225                 230                 235                 240
 Val Ala Asn Val Pro Leu Gly Leu Pro Gly Asn Ile Thr Phe Val Pro
                 245                 250                 255    
 Ile Asn Ser Val Asp Leu Asp Ser Leu Gly Leu Ser Gly Ser Ser Gln
             260                 265                 270        
 Thr Met Thr Ala Gly Ile Asn Ala Asp Gly His Leu Ile Asn Thr Gly
         275                 280                 285            
 Gln Ala Met Asp Ser Ser Asp Asn Ser Glu Arg Thr Gly Glu Arg Val
     290                 295                 300                
 Ser Pro Asp Ile Asn Glu Thr Asn Thr Asp Thr Asp Leu Phe Val Pro
 305                 310                 315                 320
 Thr Ser Ser Ser Ser Gln Leu Pro Val Thr Ile Asp Ser Thr Gly Ile
                 325                 330                 335    
 Leu Gln Gln Asn Thr Asn Ser Leu Thr Thr Ser Ser Gly Gln Val His
             340                 345                 350        
 Ser Ser Asp Leu Gln Gly Asn Tyr Ile Gln Ser Pro Val Ser Glu Glu
         355                 360                 365            
 Thr Gln Ala Gln Asn Ile Gln Val Ser Thr Ala Gln Pro Val Val Gln
     370                 375                 380                
 His Leu Gln Leu Gln Glu Ser Gln Gln Pro Thr Ser Gln Ala Gln Ile
 385                 390                 395                 400
 Val Gln Gly Ile Thr Pro Gln Thr Ile His Gly Val Gln Ala Ser Gly
                 405                 410                 415    
 Gln Asn Ile Ser Gln Gln Ala Leu Gln Asn Leu Gln Leu Gln Leu Asn
             420                 425                 430        
 Pro Gly Thr Phe Leu Ile Gln Ala Gln Thr Val Thr Pro Ser Gly Gln
         435                 440                 445            
 Val Thr Trp Gln Thr Phe Gln Val Gln Gly Val Gln Asn Leu Gln Asn
     450                 455                 460                
 Leu Gln Ile Gln Asn Thr Ala Ala Gln Gln Ile Thr Leu Thr Pro Val
 465                 470                 475                 480
 Gln Thr Leu Thr Leu Gly Gln Val Ala Ala Gly Gly Ala Phe Thr Ser
                 485                 490                 495    
 Thr Pro Val Ser Leu Ser Thr Gly Gln Leu Pro Asn Leu Gln Thr Val
             500                 505                 510        
 Thr Val Asn Ser Ile Asp Ser Ala Gly Ile Gln Leu His Pro Gly Glu
         515                 520                 525            
 Asn Ala Asp Ser Pro Ala Asp Ile Arg Ile Lys Glu Glu Glu Pro Asp
     530                 535                 540                
 Pro Glu Glu Trp Gln Leu Ser Gly Asp Ser Thr Leu Asn Thr Asn Asp
 545                 550                 555                 560
 Leu Thr His Leu Arg Val Gln Val Val Asp Glu Glu Gly Asp Gln Gln
                 565                 570                 575    
 His Gln Glu Gly Lys Arg Leu Arg Arg Val Ala Cys Thr Cys Pro Asn
             580                 585                 590        
 Cys Lys Glu Gly Gly Gly Arg Gly Thr Asn Leu Gly Lys Lys Lys Gln
         595                 600                 605            
 His Ile Cys His Ile Pro Gly Cys Gly Lys Val Tyr Gly Lys Thr Ser
     610                 615                 620                
 His Leu Arg Ala His Leu Arg Trp His Ser Gly Glu Arg Pro Phe Val
 625                 630                 635                 640
 Cys Asn Trp Met Tyr Cys Gly Lys Arg Phe Thr Arg Ser Asp Glu Leu
                 645                 650                 655    
 Gln Arg His Arg Arg Thr His Thr Gly Glu Lys Lys Phe Val Cys Pro
             660                 665                 670        
 Glu Cys Ser Lys Arg Phe Met Arg Ser Asp His Leu Ala Lys His Ile
         675                 680                 685            
 Lys Thr His Gln Asn Lys Lys Gly Ile His Ser Ser Ser Thr Val Leu
     690                 695                 700                
 Ala Ser Val Glu Ala Ala Arg Asp Asp Thr Leu Ile Thr Ala Gly Gly
 705                 710                 715                 720
 Thr Thr Leu Ile Leu Ala Asn Ile Gln Gln Gly Ser Val Ser Gly Ile
                 725                 730                 735    
 Gly Thr Val Asn Thr Ser Ala Thr Ser Asn Gln Asp Ile Leu Thr Asn
             740                 745                 750        
 Thr Glu Ile Pro Leu Gln Leu Val Thr Val Ser Gly Asn Glu Thr Met
         755                 760                 765            
 Glu
    



      <210> 957
      <211> 376
      <212> PRT
      <213> Homo sapiens


      <400> 957
 Met Pro Lys Arg Pro Ser Tyr Ala Pro Ser Pro Thr Pro Ala Ser Ala
   1               5                  10                  15    
 Thr Gln Met Pro Ser Thr Pro Ala Phe Ala Gly Tyr Asn Pro Tyr Cys
              20                  25                  30        
 His Leu Ala Tyr Ser Asn Tyr Arg Leu Gly Gly Asn Pro Ala Thr Asn
          35                  40                  45            
 Ser Arg Val Arg Gly Ser Ser Ser Ile Thr Ile Pro Lys Pro Pro Lys
      50                  55                  60                
 Pro Pro Asp Lys Pro Leu Met Pro Tyr Met Arg Tyr Ser Arg Lys Val
  65                  70                  75                  80
 Trp Asp Gln Val Lys Ala Ser Asn Pro Asp Val Lys Leu Trp Glu Ile
                  85                  90                  95    
 Gly Lys Ile Ile Ala Gly Met Trp Gln Asp Leu Ala Asp Glu Glu Lys
             100                 105                 110        
 Gln Tyr Leu Asn Glu Tyr Glu Val Glu Lys Ile Glu Tyr Asn Glu Ser
         115                 120                 125            
 Met Asn Ala His His Asn Ser Pro Val Tyr Leu Ala Tyr Ile Asn Ala
     130                 135                 140                
 Lys Ser Leu Ala Glu Ala Ala Leu Glu Glu Asp Asn Thr Ala Thr Val
 145                 150                 155                 160
 Arg Phe Gln Arg Asn Arg Arg Leu Ile Ser Glu Ile Leu Ser Glu Ser
                 165                 170                 175    
 Val Val Pro Glu Val Gln Ser Val Val Thr Thr Thr Arg Met Gln Val
             180                 185                 190        
 Pro Lys Gln Gln Val Gln Ser Leu Met Val His Gln Arg Lys Leu Glu
         195                 200                 205            
 Ala Glu Leu Leu Pro Lys Glu Asp Arg His Gln Glu Lys Ala Lys Phe
     210                 215                 220                
 Leu Glu Ser Thr Asp Ser Phe Asn Asn Glu Leu Lys Arg Leu Cys Gly
 225                 230                 235                 240
 Leu Lys Val Glu Val Asp Met Glu Lys Ile Ala Ala Glu Met Ala Gln
                 245                 250                 255    
 Ala Glu Glu Gln Ala Arg Lys Arg Gln Glu Glu Arg Glu Lys Glu Ala
             260                 265                 270        
 Ala Glu Gln Ala Glu Arg Ser Gln Ser Ser Ile Val Pro Glu Glu Glu
         275                 280                 285            
 Gln Ala Ala Asn Lys Gly Glu Glu Lys Lys Asp Asp Glu Asn Ile Pro
     290                 295                 300                
 Met Glu Thr Glu Glu Thr His Leu Glu Glu Thr Thr Glu Ser Gln Gln
 305                 310                 315                 320
 Asn Gly Glu Glu Gly Thr Ser Thr Pro Glu Asp Lys Glu Ser Gly Gln
                 325                 330                 335    
 Glu Gly Val Asp Ser Met Ala Glu Glu Gly Thr Ser Asp Ser Asn Thr
             340                 345                 350        
 Gly Ser Glu Ser Asn Ser Ala Thr Val Glu Glu Pro Pro Thr Asp Pro
         355                 360                 365            
 Ile Pro Glu Asp Glu Lys Lys Glu
     370                 375    



      <210> 958
      <211> 805
      <212> PRT
      <213> Homo sapiens


      <400> 958
 Met Ala Thr Glu Thr Lys Asp Glu Gln Ile Ser Gly Thr Val Ser Ser
   1               5                  10                  15    
 Gln Lys Gln Pro Ala Leu Lys Ala Thr Ser Asp Lys Lys Asp Ser Val
              20                  25                  30        
 Ser Asn Ile Pro Thr Glu Ile Lys Asp Gly Gln Gln Ser Gly Thr Val
          35                  40                  45            
 Ser Ser Gln Lys Gln Pro Ala Trp Lys Ala Thr Ser Val Lys Lys Asp
      50                  55                  60                
 Ser Val Ser Asn Ile Ala Thr Glu Ile Lys Asp Gly Gln Ile Arg Gly
  65                  70                  75                  80
 Thr Val Ser Ser Gln Arg Arg Pro Ala Leu Lys Thr Thr Gly Asp Glu
                  85                  90                  95    
 Lys Asp Ser Val Ser Asn Ile Ala Arg Glu Ile Lys Asp Gly Glu Lys
             100                 105                 110        
 Ser Gly Thr Val Ser Pro Gln Lys Gln Ser Ala Gln Lys Val Ile Phe
         115                 120                 125            
 Lys Lys Lys Val Ser Leu Leu Asn Ile Ala Thr Arg Ile Thr Gly Gly
     130                 135                 140                
 Gly Lys Ser Gly Thr Glu Tyr Pro Glu Asn Leu Arg Thr Leu Lys Ala
 145                 150                 155                 160
 Thr Ile Glu Asn Lys Asp Ser Val Leu Asn Thr Ala Thr Lys Met Lys
                 165                 170                 175    
 Asp Val Gln Thr Ser Thr Pro Glu Gln Asp Leu Glu Met Ala Ser Glu
             180                 185                 190        
 Gly Glu Gln Lys Arg Leu Glu Glu Tyr Glu Asn Asn Gln Pro Gln Val
         195                 200                 205            
 Lys Asn Gln Ile His Ser Arg Asp Asp Leu Asp Asp Ile Ile Gln Ser
     210                 215                 220                
 Ser Gln Thr Val Ser Glu Asp Gly Asp Ser Leu Cys Cys Asn Cys Lys
 225                 230                 235                 240
 Asn Val Ile Leu Leu Ile Asp Gln His Glu Met Lys Cys Lys Asp Cys
                 245                 250                 255    
 Val His Leu Leu Lys Ile Lys Lys Thr Phe Cys Leu Cys Lys Arg Leu
             260                 265                 270        
 Thr Glu Leu Lys Asp Asn His Cys Glu Gln Leu Arg Val Lys Ile Arg
         275                 280                 285            
 Lys Leu Lys Asn Lys Ala Ser Val Leu Gln Lys Arg Leu Ser Glu Lys
     290                 295                 300                
 Glu Glu Ile Lys Ser Gln Leu Lys His Glu Thr Leu Glu Leu Glu Lys
 305                 310                 315                 320
 Glu Leu Cys Ser Leu Arg Phe Ala Ile Gln Gln Glu Lys Lys Lys Arg
                 325                 330                 335    
 Arg Asn Val Glu Glu Val His Gln Lys Val Arg Glu Lys Leu Arg Ile
             340                 345                 350        
 Thr Glu Glu Gln Tyr Arg Ile Glu Ala Asp Val Thr Lys Pro Ile Lys
         355                 360                 365            
 Pro Ala Leu Lys Ser Ala Glu Val Glu Leu Lys Thr Gly Gly Asn Asn
     370                 375                 380                
 Ser Asn Gln Val Ser Glu Thr Asp Glu Lys Glu Asp Leu Leu His Glu
 385                 390                 395                 400
 Asn Arg Leu Met Gln Asp Glu Ile Ala Arg Leu Arg Leu Glu Lys Asp
                 405                 410                 415    
 Thr Ile Lys Asn Gln Asn Leu Glu Lys Lys Tyr Leu Lys Asp Phe Glu
             420                 425                 430        
 Ile Val Lys Arg Lys His Glu Asp Leu Gln Lys Ala Leu Lys Arg Asn
         435                 440                 445            
 Gly Glu Thr Leu Ala Lys Thr Ile Ala Cys Tyr Ser Gly Gln Leu Ala
     450                 455                 460                
 Ala Leu Thr Asp Glu Asn Thr Thr Leu Arg Ser Lys Leu Glu Lys Gln
 465                 470                 475                 480
 Arg Glu Ser Arg Gln Arg Leu Glu Thr Glu Met Gln Ser Tyr His Cys
                 485                 490                 495    
 Arg Leu Asn Ala Ala Arg Cys Asp His Asp Gln Ser His Ser Ser Lys
             500                 505                 510        
 Arg Asp Gln Glu Leu Ala Phe Gln Gly Thr Val Asp Lys Cys Arg His
         515                 520                 525            
 Leu Gln Glu Asn Leu Asn Ser His Val Leu Ile Leu Ser Leu Gln Leu
     530                 535                 540                
 Ser Lys Ala Glu Ser Lys Ser Arg Val Leu Lys Thr Glu Leu His Tyr
 545                 550                 555                 560
 Thr Gly Glu Ala Leu Lys Glu Lys Ala Leu Val Phe Glu His Val Gln
                 565                 570                 575    
 Ser Glu Leu Lys Gln Lys Gln Ser Gln Met Lys Asp Ile Glu Lys Met
             580                 585                 590        
 Tyr Lys Ser Gly Tyr Asn Thr Met Glu Lys Cys Ile Glu Lys Gln Glu
         595                 600                 605            
 Arg Phe Cys Gln Leu Lys Lys Gln Asn Met Leu Leu Gln Gln Gln Leu
     610                 615                 620                
 Asp Asp Ala Arg Asn Lys Ala Asp Asn Gln Glu Lys Ala Ile Leu Asn
 625                 630                 635                 640
 Ile Gln Ala Arg Cys Asp Ala Arg Val Gln Asn Leu Gln Ala Glu Cys
                 645                 650                 655    
 Arg Lys His Arg Leu Leu Leu Glu Glu Asp Asn Lys Met Leu Val Asn
             660                 665                 670        
 Glu Leu Asn His Ser Lys Glu Lys Glu Cys Gln Tyr Glu Lys Glu Lys
         675                 680                 685            
 Ala Glu Arg Glu Val Ala Val Arg Gln Leu Gln Gln Lys Arg Asp Asp
     690                 695                 700                
 Val Leu Asn Lys Gly Ser Ala Thr Lys Ala Leu Leu Asp Ala Ser Ser
 705                 710                 715                 720
 Arg His Cys Thr Tyr Leu Glu Asn Gly Met Gln Asp Ser Arg Lys Lys
                 725                 730                 735    
 Leu Asp Gln Met Arg Ser Gln Phe Gln Glu Ile Gln Asp Gln Leu Thr
             740                 745                 750        
 Ala Thr Ile Arg Cys Thr Lys Glu Met Glu Gly Asp Thr Gln Lys Leu
         755                 760                 765            
 Glu Val Glu His Val Met Met Arg Lys Ile Ile Lys Lys Gln Asp Asp
     770                 775                 780                
 Gln Ile Glu Arg Leu Glu Lys Ile Leu Gln His Ser Ser Leu Met Leu
 785                 790                 795                 800
 Gln Val Phe Glu Ser
                 805



      <210> 959
      <211> 756
      <212> PRT
      <213> Homo sapiens


      <400> 959
 Met Ala Thr Glu Thr Lys Asp Glu Gln Ile Ser Gly Thr Val Ser Ser
   1               5                  10                  15    
 Gln Lys Gln Pro Ala Leu Lys Ala Thr Ser Asp Lys Lys Asp Ser Val
              20                  25                  30        
 Ser Asn Ile Pro Thr Glu Ile Lys Asp Gly Gln Gln Ser Gly Thr Val
          35                  40                  45            
 Ser Ser Gln Lys Gln Pro Ala Trp Lys Ala Thr Ser Val Lys Lys Asp
      50                  55                  60                
 Ser Val Ser Asn Ile Ala Thr Glu Ile Lys Asp Gly Gln Ile Arg Gly
  65                  70                  75                  80
 Thr Val Ser Ser Gln Arg Arg Pro Ala Leu Lys Thr Thr Gly Asp Glu
                  85                  90                  95    
 Lys Asp Ser Val Ser Asn Ile Ala Arg Glu Ile Lys Asp Gly Glu Lys
             100                 105                 110        
 Ser Gly Thr Val Ser Pro Gln Lys Gln Ser Ala Gln Lys Val Ile Phe
         115                 120                 125            
 Lys Lys Lys Val Ser Leu Leu Asn Ile Ala Thr Arg Ile Thr Gly Gly
     130                 135                 140                
 Gly Lys Ser Gly Thr Glu Tyr Pro Glu Asn Leu Arg Thr Leu Lys Ala
 145                 150                 155                 160
 Thr Ile Glu Asn Lys Asp Ser Val Leu Asn Thr Ala Thr Lys Met Lys
                 165                 170                 175    
 Asp Val Gln Thr Ser Thr Pro Glu Gln Asp Leu Glu Met Ala Ser Glu
             180                 185                 190        
 Gly Glu Gln Lys Arg Leu Glu Glu Tyr Glu Asn Asn Gln Pro Gln Val
         195                 200                 205            
 Lys Asn Gln Ile His Ser Arg Asp Asp Leu Asp Asp Ile Ile Gln Ser
     210                 215                 220                
 Ser Gln Thr Val Ser Glu Asp Gly Asp Ser Leu Cys Cys Asn Cys Lys
 225                 230                 235                 240
 Asn Val Ile Leu Leu Ile Asp Gln His Glu Met Lys Cys Lys Asp Cys
                 245                 250                 255    
 Val His Leu Leu Lys Ile Lys Lys Thr Phe Cys Leu Cys Lys Arg Leu
             260                 265                 270        
 Thr Glu Leu Lys Asp Asn His Cys Glu Gln Leu Arg Val Lys Ile Arg
         275                 280                 285            
 Lys Leu Lys Asn Lys Ala Ser Val Leu Gln Lys Arg Leu Ser Glu Lys
     290                 295                 300                
 Glu Glu Ile Lys Ser Gln Leu Lys His Glu Thr Leu Glu Leu Glu Lys
 305                 310                 315                 320
 Glu Leu Cys Ser Leu Arg Phe Ala Ile Gln Gln Glu Lys Lys Lys Arg
                 325                 330                 335    
 Arg Asn Val Glu Glu Val His Gln Lys Val Arg Glu Lys Leu Arg Ile
             340                 345                 350        
 Thr Glu Glu Gln Tyr Arg Ile Glu Ala Asp Val Thr Lys Pro Ile Lys
         355                 360                 365            
 Pro Ala Leu Lys Ser Ala Glu Val Glu Leu Lys Thr Gly Gly Asn Asn
     370                 375                 380                
 Ser Asn Gln Val Ser Glu Thr Asp Glu Lys Glu Asp Leu Leu His Glu
 385                 390                 395                 400
 Asn Arg Leu Met Gln Asp Glu Ile Ala Arg Leu Arg Leu Glu Lys Asp
                 405                 410                 415    
 Thr Ile Lys Asn Gln Asn Leu Glu Lys Lys Tyr Leu Lys Asp Phe Glu
             420                 425                 430        
 Ile Val Lys Arg Lys His Glu Asp Leu Gln Lys Ala Leu Lys Arg Asn
         435                 440                 445            
 Gly Glu Thr Leu Ala Lys Thr Ile Ala Cys Tyr Ser Gly Gln Leu Ala
     450                 455                 460                
 Ala Leu Thr Asp Glu Asn Thr Thr Leu Arg Ser Lys Leu Glu Lys Gln
 465                 470                 475                 480
 Arg Glu Ser Arg Gln Arg Leu Glu Thr Glu Met Gln Ser Tyr His Cys
                 485                 490                 495    
 Arg Leu Asn Ala Ala Arg Cys Asp His Asp Gln Ser His Ser Ser Lys
             500                 505                 510        
 Arg Asp Gln Glu Leu Ala Phe Gln Gly Thr Val Asp Lys Cys Arg His
         515                 520                 525            
 Leu Gln Glu Asn Leu Asn Ser His Val Leu Ile Leu Ser Leu Gln Leu
     530                 535                 540                
 Ser Lys Ala Glu Ser Lys Ser Arg Val Leu Lys Thr Glu Leu His Tyr
 545                 550                 555                 560
 Thr Gly Glu Ala Leu Lys Glu Lys Ala Leu Val Phe Glu His Val Gln
                 565                 570                 575    
 Ser Glu Leu Lys Gln Lys Gln Ser Gln Met Lys Asp Ile Glu Lys Met
             580                 585                 590        
 Tyr Lys Ser Gly Tyr Asn Thr Met Glu Lys Cys Ile Glu Lys Gln Glu
         595                 600                 605            
 Arg Phe Cys Gln Leu Lys Lys Gln Asn Met Leu Leu Gln Gln Gln Leu
     610                 615                 620                
 Asp Asp Ala Arg Asn Lys Ala Asp Asn Gln Glu Lys Ala Ile Leu Asn
 625                 630                 635                 640
 Ile Gln Ala Arg Cys Asp Ala Arg Val Gln Asn Leu Gln Ala Glu Cys
                 645                 650                 655    
 Arg Lys His Arg Leu Leu Leu Glu Glu Asp Asn Lys Met Leu Val Asn
             660                 665                 670        
 Glu Leu Asn His Ser Lys Glu Lys Glu Cys Gln Tyr Glu Lys Glu Lys
         675                 680                 685            
 Ala Glu Arg Glu Val Ala Val Arg Gln Leu Gln Gln Lys Arg Asp Asp
     690                 695                 700                
 Val Leu Asn Lys Gly Ser Ala Thr Lys Ala Leu Leu Asp Ala Ser Ser
 705                 710                 715                 720
 Arg His Cys Thr Tyr Leu Glu Asn Gly Met Gln Asp Ser Arg Lys Lys
                 725                 730                 735    
 Leu Asp Gln Met Arg Ser Gln Val Cys Met Gln Leu Cys Thr Pro Thr
             740                 745                 750        
 Thr Val Asn Leu
         755    



      <210> 960
      <211> 462
      <212> PRT
      <213> Homo sapiens


      <400> 960
 Met Ser Glu Gly Val Asp Leu Ile Asp Ile Tyr Ala Asp Glu Glu Phe
   1               5                  10                  15    
 Asn Gln Asp Pro Glu Phe Asn Asn Thr Asp Gln Ile Asp Leu Tyr Asp
              20                  25                  30        
 Asp Val Leu Thr Ala Thr Ser Gln Pro Ser Asp Asp Arg Ser Ser Ser
          35                  40                  45            
 Thr Glu Pro Pro Pro Pro Val Arg Gln Glu Pro Ser Pro Lys Pro Asn
      50                  55                  60                
 Asn Lys Thr Pro Ala Ile Leu Tyr Thr Tyr Ser Gly Leu Arg Asn Arg
  65                  70                  75                  80
 Arg Ala Ala Val Tyr Val Gly Ser Phe Ser Trp Trp Thr Thr Asp Gln
                  85                  90                  95    
 Gln Leu Ile Gln Val Ile Arg Ser Ile Gly Val Tyr Asp Val Val Glu
             100                 105                 110        
 Leu Lys Phe Ala Glu Asn Arg Ala Asn Gly Gln Ser Lys Gly Tyr Ala
         115                 120                 125            
 Glu Val Val Val Ala Ser Glu Asn Ser Val His Lys Leu Leu Glu Leu
     130                 135                 140                
 Leu Pro Gly Lys Val Leu Asn Gly Glu Lys Val Asp Val Arg Pro Ala
 145                 150                 155                 160
 Thr Arg Gln Asn Leu Ser Gln Phe Glu Ala Gln Ala Arg Lys Arg Ile
                 165                 170                 175    
 Pro Pro Arg Ala His Ser Arg Asp Ser Ser Asp Ser Ala Asp Gly Arg
             180                 185                 190        
 Ala Thr Pro Ser Glu Asn Leu Val Pro Ser Ser Ala Arg Val Asp Lys
         195                 200                 205            
 Pro Pro Ser Val Leu Pro Tyr Phe Asn Arg Pro Pro Ser Ala Leu Pro
     210                 215                 220                
 Leu Met Gly Leu Pro Pro Pro Pro Ile Pro Pro Pro Pro Pro Leu Ser
 225                 230                 235                 240
 Ser Ser Phe Gly Val Pro Pro Pro Pro Pro Gly Ile His Tyr Gln His
                 245                 250                 255    
 Leu Met Pro Pro Pro Pro Arg Leu Pro Pro His Leu Ala Val Pro Pro
             260                 265                 270        
 Pro Gly Ala Ile Pro Pro Ala Leu His Leu Asn Pro Ala Phe Phe Pro
         275                 280                 285            
 Pro Ala Asn Ala Thr Val Gly Pro Pro Pro Asp Thr Tyr Met Lys Ala
     290                 295                 300                
 Ser Ala Pro Tyr Asn His His Gly Ser Arg Asp Ser Gly Pro Pro Pro
 305                 310                 315                 320
 Ser Thr Val Ser Glu Ala Glu Phe Glu Asp Ile Met Lys Arg Asn Arg
                 325                 330                 335    
 Ala Ile Ser Ser Ser Ala Ile Ser Lys Ala Val Ser Gly Ala Ser Ala
             340                 345                 350        
 Gly Asp Tyr Ser Asp Ala Ile Glu Thr Leu Leu Thr Ala Ile Ala Val
         355                 360                 365            
 Ile Lys Gln Ser Arg Val Ala Asn Asp Glu Arg Cys Arg Val Leu Ile
     370                 375                 380                
 Ser Ser Leu Lys Asp Cys Leu His Gly Ile Glu Ala Lys Ser Tyr Ser
 385                 390                 395                 400
 Val Gly Ala Ser Gly Ser Ser Ser Arg Lys Arg His Arg Ser Arg Glu
                 405                 410                 415    
 Arg Ser Pro Ser Arg Ser Arg Glu Ser Ser Arg Arg His Arg Asp Leu
             420                 425                 430        
 Leu His Asn Glu Asp Arg His Asp Asp Tyr Phe Gln Glu Arg Asn Arg
         435                 440                 445            
 Glu His Glu Arg His Arg Asp Arg Glu Arg Asp Arg His His
     450                 455                 460        



      <210> 961
      <211> 266
      <212> PRT
      <213> Homo sapiens


      <400> 961
 Met Ile Glu Asp Glu Glu Gly Leu Val Asp Asp Arg Ala Pro Thr Thr
   1               5                  10                  15    
 Thr Arg Gly Leu Trp Ala Ile Ser Glu Thr Glu Arg Ser Met Lys Ala
              20                  25                  30        
 Ile Leu Ser Phe Ala Lys Ser His Arg Phe Asp Val Glu Phe Val Asp
          35                  40                  45            
 Glu Gly Ser Thr Ser Met Asp Leu Phe Glu Ala Trp Lys Lys Glu Tyr
      50                  55                  60                
 Lys Leu Leu His Glu Tyr Trp Met Ala Leu Arg Asn Arg Val Ser Ala
  65                  70                  75                  80
 Val Asp Glu Leu Ala Met Ala Thr Glu Arg Leu Arg Val Arg Asp Pro
                  85                  90                  95    
 Arg Glu Pro Lys Pro Asn Pro Pro Val Leu His Ile Ile Glu Pro His
             100                 105                 110        
 Glu Val Glu Gln Asn Arg Ile Lys Leu Leu Asn Asp Lys Ala Val Ala
         115                 120                 125            
 Thr Ser Gln Leu Gln Lys Lys Leu Gly Gln Leu Leu Tyr Leu Thr Asn
     130                 135                 140                
 Leu Glu Lys Ser Gln Asp Lys Thr Ser Gly Gly Val Asn Pro Glu Pro
 145                 150                 155                 160
 Cys Pro Ile Cys Ala Arg Gln Leu Gly Lys Gln Trp Ala Val Leu Thr
                 165                 170                 175    
 Cys Gly His Cys Phe Cys Asn Glu Cys Ile Ser Ile Ile Ile Glu Gln
             180                 185                 190        
 Tyr Ser Val Gly Ser His Arg Ser Ser Ile Lys Cys Ala Ile Cys Arg
         195                 200                 205            
 Gln Thr Thr Ser His Lys Glu Ile Ser Tyr Val Phe Thr Ser Glu Lys
     210                 215                 220                
 Ala Asn Gln Glu Glu Asp Ile Pro Val Lys Gly Ser His Ser Thr Lys
 225                 230                 235                 240
 Val Glu Ala Val Val Arg Thr Leu Met Lys Ile Gln Leu Arg Asp Pro
                 245                 250                 255    
 Gly Ala Lys Ala Leu Val Phe Ser Thr Val
             260                 265    



      <210> 962
      <211> 996
      <212> PRT
      <213> Homo sapiens


      <400> 962
 Met Arg Ser Ala Lys Ser Ala Ser Ser Ser Glu Glu Leu Ile Asn Lys
   1               5                  10                  15    
 Leu Asn Phe Leu Asp Glu Ala Glu Lys Asp Leu Ala Thr Val Asn Ser
              20                  25                  30        
 Asn Pro Phe Asp Asp Pro Asp Ala Ala Glu Leu Asn Pro Phe Gly Asp
          35                  40                  45            
 Pro Asp Ser Glu Glu Pro Ile Thr Glu Thr Ala Ser Pro Arg Lys Thr
      50                  55                  60                
 Glu Asp Ser Phe Tyr Asn Asn Ser Tyr Asn Pro Phe Lys Glu Val Gln
  65                  70                  75                  80
 Thr Pro Gln Tyr Leu Asn Pro Phe Asp Glu Pro Glu Ala Phe Val Thr
                  85                  90                  95    
 Ile Lys Asp Ser Pro Pro Gln Ser Thr Lys Arg Lys Asn Ile Arg Pro
             100                 105                 110        
 Val Asp Met Ser Lys Tyr Leu Tyr Ala Asp Ser Ser Lys Thr Glu Glu
         115                 120                 125            
 Glu Glu Leu Asp Glu Ser Asn Pro Phe Tyr Glu Pro Lys Ser Thr Pro
     130                 135                 140                
 Pro Pro Asn Asn Leu Val Asn Pro Val Gln Glu Leu Glu Thr Glu Arg
 145                 150                 155                 160
 Arg Val Lys Arg Lys Ala Pro Ala Pro Pro Val Leu Ser Pro Lys Thr
                 165                 170                 175    
 Gly Val Leu Asn Glu Asn Thr Val Ser Ala Gly Lys Asp Leu Ser Thr
             180                 185                 190        
 Ser Pro Lys Pro Ser Pro Ile Pro Ser Pro Val Leu Gly Arg Lys Pro
         195                 200                 205            
 Asn Ala Ser Gln Ser Leu Leu Val Trp Cys Lys Glu Val Thr Lys Asn
     210                 215                 220                
 Tyr Arg Gly Val Lys Ile Thr Asn Phe Thr Thr Ser Trp Arg Asn Gly
 225                 230                 235                 240
 Leu Ser Phe Cys Ala Ile Leu His His Phe Arg Pro Asp Leu Ile Asp
                 245                 250                 255    
 Tyr Lys Ser Leu Asn Pro Gln Asp Ile Lys Glu Asn Asn Lys Lys Ala
             260                 265                 270        
 Tyr Asp Gly Phe Ala Ser Ile Gly Ile Ser Arg Leu Leu Glu Pro Ser
         275                 280                 285            
 Asp Met Val Leu Leu Ala Ile Pro Asp Lys Leu Thr Val Met Thr Tyr
     290                 295                 300                
 Leu Tyr Gln Ile Arg Ala His Phe Ser Gly Gln Glu Leu Asn Val Val
 305                 310                 315                 320
 Gln Ile Glu Glu Asn Ser Ser Lys Ser Thr Tyr Lys Val Gly Asn Tyr
                 325                 330                 335    
 Glu Thr Asp Thr Asn Ser Ser Val Asp Gln Glu Lys Phe Tyr Ala Glu
             340                 345                 350        
 Leu Ser Asp Leu Lys Arg Glu Pro Glu Leu Gln Gln Pro Ile Ser Gly
         355                 360                 365            
 Ala Val Asp Phe Leu Ser Gln Asp Asp Ser Val Phe Val Asn Asp Ser
     370                 375                 380                
 Gly Val Gly Glu Ser Glu Ser Glu His Gln Thr Pro Asp Asp His Leu
 385                 390                 395                 400
 Ser Pro Ser Thr Ala Ser Pro Tyr Cys Arg Arg Thr Lys Ser Asp Thr
                 405                 410                 415    
 Glu Pro Gln Lys Ser Gln Gln Ser Ser Gly Arg Thr Ser Gly Ser Asp
             420                 425                 430        
 Asp Pro Gly Ile Cys Ser Asn Thr Asp Ser Thr Gln Ala Gln Val Leu
         435                 440                 445            
 Leu Gly Lys Lys Arg Leu Leu Lys Ala Glu Thr Leu Glu Leu Ser Asp
     450                 455                 460                
 Leu Tyr Val Ser Asp Lys Lys Lys Asp Met Ser Pro Pro Phe Ile Cys
 465                 470                 475                 480
 Glu Glu Thr Asp Glu Gln Lys Leu Gln Thr Leu Asp Ile Gly Ser Asn
                 485                 490                 495    
 Leu Glu Lys Glu Lys Leu Glu Asn Ser Arg Ser Leu Glu Cys Arg Ser
             500                 505                 510        
 Asp Pro Glu Ser Pro Ile Lys Lys Thr Ser Leu Ser Pro Thr Ser Lys
         515                 520                 525            
 Leu Gly Tyr Ser Tyr Ser Arg Asp Leu Asp Leu Ala Lys Lys Lys His
     530                 535                 540                
 Ala Ser Leu Arg Gln Thr Glu Ser Asp Pro Asp Ala Asp Arg Thr Thr
 545                 550                 555                 560
 Leu Asn His Ala Asp His Ser Ser Lys Ile Val Gln His Arg Leu Leu
                 565                 570                 575    
 Ser Arg Gln Glu Glu Leu Lys Glu Arg Ala Arg Val Leu Leu Glu Gln
             580                 585                 590        
 Ala Arg Arg Asp Ala Ala Leu Lys Ala Gly Asn Lys His Asn Thr Asn
         595                 600                 605            
 Thr Ala Thr Pro Phe Cys Asn Arg Gln Leu Ser Asp Gln Gln Asp Glu
     610                 615                 620                
 Glu Arg Arg Arg Gln Leu Arg Glu Arg Ala Arg Gln Leu Ile Ala Glu
 625                 630                 635                 640
 Ala Arg Ser Gly Val Lys Met Ser Glu Leu Pro Ser Tyr Gly Glu Met
                 645                 650                 655    
 Ala Ala Glu Lys Leu Lys Glu Arg Ser Lys Ala Ser Gly Asp Glu Asn
             660                 665                 670        
 Asp Asn Ile Glu Ile Asp Thr Asn Glu Glu Ile Pro Glu Gly Phe Val
         675                 680                 685            
 Val Gly Gly Gly Asp Glu Leu Thr Asn Leu Glu Asn Asp Leu Asp Thr
     690                 695                 700                
 Pro Glu Gln Asn Ser Lys Leu Val Asp Leu Lys Leu Lys Lys Leu Leu
 705                 710                 715                 720
 Glu Val Gln Pro Gln Val Ala Asn Ser Pro Ser Ser Ala Ala Gln Lys
                 725                 730                 735    
 Ala Val Thr Glu Ser Ser Glu Gln Asp Met Lys Ser Gly Thr Glu Asp
             740                 745                 750        
 Leu Arg Thr Glu Arg Leu Gln Lys Thr Thr Glu Arg Phe Arg Asn Pro
         755                 760                 765            
 Val Val Phe Ser Lys Asp Ser Thr Val Arg Lys Thr Gln Leu Gln Ser
     770                 775                 780                
 Phe Ser Gln Tyr Ile Glu Asn Arg Pro Glu Met Lys Arg Gln Arg Ser
 785                 790                 795                 800
 Ile Gln Glu Asp Thr Lys Lys Gly Asn Glu Glu Lys Ala Ala Ile Thr
                 805                 810                 815    
 Glu Thr Gln Arg Lys Pro Ser Glu Asp Glu Val Leu Asn Lys Gly Phe
             820                 825                 830        
 Lys Asp Thr Ser Gln Tyr Val Val Gly Glu Leu Ala Ala Leu Glu Asn
         835                 840                 845            
 Glu Gln Lys Gln Ile Asp Thr Arg Ala Ala Leu Val Glu Lys Arg Leu
     850                 855                 860                
 Arg Tyr Leu Met Asp Thr Gly Arg Asn Thr Glu Glu Glu Glu Ala Met
 865                 870                 875                 880
 Met Gln Glu Trp Phe Met Leu Val Asn Lys Lys Asn Ala Leu Ile Arg
                 885                 890                 895    
 Arg Met Asn Gln Leu Ser Leu Leu Glu Lys Glu His Asp Leu Glu Arg
             900                 905                 910        
 Arg Tyr Glu Leu Leu Asn Arg Glu Leu Arg Ala Met Leu Ala Ile Glu
         915                 920                 925            
 Asp Trp Gln Lys Thr Glu Ala Gln Lys Arg Arg Glu Gln Leu Leu Leu
     930                 935                 940                
 Asp Glu Leu Val Ala Leu Val Asn Lys Arg Asp Ala Leu Val Arg Asp
 945                 950                 955                 960
 Leu Asp Ala Gln Glu Lys Gln Ala Glu Glu Glu Asp Glu His Leu Glu
                 965                 970                 975    
 Arg Thr Leu Glu Gln Asn Lys Gly Lys Met Ala Lys Lys Glu Glu Lys
             980                 985                 990        
 Cys Val Leu Gln
         995    



      <210> 963
      <211> 960
      <212> PRT
      <213> Homo sapiens


      <400> 963
 Met Arg Ser Ala Lys Ser Ala Ser Ser Ser Glu Glu Leu Ile Asn Lys
   1               5                  10                  15    
 Leu Asn Phe Leu Asp Glu Ala Glu Lys Asp Leu Ala Thr Val Asn Ser
              20                  25                  30        
 Asn Pro Phe Asp Asp Pro Asp Ala Ala Glu Leu Asn Pro Phe Gly Asp
          35                  40                  45            
 Pro Asp Ser Glu Glu Pro Ile Thr Glu Thr Ala Ser Pro Arg Lys Thr
      50                  55                  60                
 Glu Asp Ser Phe Tyr Asn Asn Ser Tyr Asn Pro Phe Lys Glu Val Gln
  65                  70                  75                  80
 Thr Pro Gln Tyr Leu Asn Pro Phe Asp Glu Pro Glu Ala Phe Val Thr
                  85                  90                  95    
 Ile Lys Asp Ser Pro Pro Gln Ser Thr Lys Arg Lys Asn Ile Arg Pro
             100                 105                 110        
 Val Asp Met Ser Lys Tyr Leu Tyr Ala Asp Ser Ser Lys Thr Glu Glu
         115                 120                 125            
 Glu Glu Leu Asp Glu Ser Asn Pro Phe Tyr Glu Pro Lys Ser Thr Pro
     130                 135                 140                
 Pro Pro Asn Asn Leu Val Asn Pro Val Gln Glu Leu Glu Thr Glu Arg
 145                 150                 155                 160
 Arg Val Lys Arg Lys Ala Pro Ala Pro Pro Val Leu Ser Pro Lys Thr
                 165                 170                 175    
 Gly Val Leu Asn Glu Asn Thr Val Ser Ala Gly Lys Asp Leu Ser Thr
             180                 185                 190        
 Ser Pro Lys Pro Ser Pro Ile Pro Ser Pro Val Leu Gly Arg Lys Pro
         195                 200                 205            
 Asn Ala Ser Gln Ser Leu Leu Val Trp Cys Lys Glu Val Thr Lys Asn
     210                 215                 220                
 Tyr Arg Gly Val Lys Ile Thr Asn Phe Thr Thr Ser Trp Arg Asn Gly
 225                 230                 235                 240
 Leu Ser Phe Cys Ala Ile Leu His His Phe Arg Pro Asp Leu Ile Asp
                 245                 250                 255    
 Tyr Lys Ser Leu Asn Pro Gln Asp Ile Lys Glu Asn Asn Lys Lys Ala
             260                 265                 270        
 Tyr Asp Gly Phe Ala Ser Ile Gly Ile Ser Arg Leu Leu Glu Pro Ser
         275                 280                 285            
 Asp Met Val Leu Leu Ala Ile Pro Asp Lys Leu Thr Val Met Thr Tyr
     290                 295                 300                
 Leu Tyr Gln Ile Arg Ala His Phe Ser Gly Gln Glu Leu Asn Val Val
 305                 310                 315                 320
 Gln Ile Glu Glu Asn Ser Ser Lys Ser Thr Tyr Lys Val Gly Asn Tyr
                 325                 330                 335    
 Glu Thr Asp Thr Asn Ser Ser Val Asp Gln Glu Lys Phe Tyr Ala Glu
             340                 345                 350        
 Leu Ser Asp Leu Lys Arg Glu Pro Glu Leu Gln Gln Pro Ile Ser Gly
         355                 360                 365            
 Ala Val Asp Phe Leu Ser Gln Asp Asp Ser Val Phe Val Asn Asp Ser
     370                 375                 380                
 Gly Val Gly Glu Ser Glu Ser Glu His Gln Thr Pro Asp Asp His Leu
 385                 390                 395                 400
 Ser Pro Ser Thr Ala Ser Pro Tyr Cys Arg Arg Thr Lys Ser Asp Thr
                 405                 410                 415    
 Glu Pro Gln Lys Ser Gln Gln Ser Ser Gly Arg Thr Ser Gly Ser Asp
             420                 425                 430        
 Asp Pro Gly Ile Cys Ser Asn Thr Asp Ser Thr Gln Ala Gln Val Leu
         435                 440                 445            
 Leu Gly Lys Lys Arg Leu Leu Lys Ala Glu Thr Leu Glu Leu Ser Asp
     450                 455                 460                
 Leu Tyr Val Ser Asp Lys Lys Lys Asp Met Ser Pro Pro Phe Ile Cys
 465                 470                 475                 480
 Glu Glu Thr Asp Glu Gln Lys Leu Gln Thr Leu Asp Ile Gly Ser Asn
                 485                 490                 495    
 Leu Glu Lys Glu Lys Leu Glu Asn Ser Arg Ser Leu Glu Cys Arg Ser
             500                 505                 510        
 Asp Pro Glu Ser Pro Ile Lys Lys Thr Ser Leu Ser Pro Thr Ser Lys
         515                 520                 525            
 Leu Gly Tyr Ser Tyr Ser Arg Asp Leu Asp Leu Ala Lys Lys Lys His
     530                 535                 540                
 Ala Ser Leu Arg Gln Thr Glu Ser Asp Pro Asp Ala Asp Arg Thr Thr
 545                 550                 555                 560
 Leu Asn His Ala Asp His Ser Ser Lys Ile Val Gln His Arg Leu Leu
                 565                 570                 575    
 Ser Arg Gln Glu Glu Leu Lys Glu Arg Ala Arg Val Leu Leu Glu Gln
             580                 585                 590        
 Ala Arg Arg Asp Ala Ala Leu Lys Ala Gly Asn Lys His Asn Thr Asn
         595                 600                 605            
 Thr Ala Thr Pro Phe Cys Asn Arg Gln Leu Ser Asp Gln Gln Asp Glu
     610                 615                 620                
 Glu Arg Arg Arg Gln Leu Arg Glu Arg Ala Arg Gln Leu Ile Ala Glu
 625                 630                 635                 640
 Ala Arg Ser Gly Val Lys Met Ser Glu Leu Pro Ser Tyr Gly Glu Met
                 645                 650                 655    
 Ala Ala Glu Lys Leu Lys Glu Arg Ser Lys Ala Ser Gly Glu Gln Asn
             660                 665                 670        
 Ser Lys Leu Val Asp Leu Lys Leu Lys Lys Leu Leu Glu Val Gln Pro
         675                 680                 685            
 Gln Val Ala Asn Ser Pro Ser Ser Ala Ala Gln Lys Ala Val Thr Glu
     690                 695                 700                
 Ser Ser Glu Gln Asp Met Lys Ser Gly Thr Glu Asp Leu Arg Thr Glu
 705                 710                 715                 720
 Arg Leu Gln Lys Thr Thr Glu Arg Phe Arg Asn Pro Val Val Phe Ser
                 725                 730                 735    
 Lys Asp Ser Thr Val Arg Lys Thr Gln Leu Gln Ser Phe Ser Gln Tyr
             740                 745                 750        
 Ile Glu Asn Arg Pro Glu Met Lys Arg Gln Arg Ser Ile Gln Glu Asp
         755                 760                 765            
 Thr Lys Lys Gly Asn Glu Glu Lys Ala Ala Ile Thr Glu Thr Gln Arg
     770                 775                 780                
 Lys Pro Ser Glu Asp Glu Val Leu Asn Lys Gly Phe Lys Asp Thr Ser
 785                 790                 795                 800
 Gln Tyr Val Val Gly Glu Leu Ala Ala Leu Glu Asn Glu Gln Lys Gln
                 805                 810                 815    
 Ile Asp Thr Arg Ala Ala Leu Val Glu Lys Arg Leu Arg Tyr Leu Met
             820                 825                 830        
 Asp Thr Gly Arg Asn Thr Glu Glu Glu Glu Ala Met Met Gln Glu Trp
         835                 840                 845            
 Phe Met Leu Val Asn Lys Lys Asn Ala Leu Ile Arg Arg Met Asn Gln
     850                 855                 860                
 Leu Ser Leu Leu Glu Lys Glu His Asp Leu Glu Arg Arg Tyr Glu Leu
 865                 870                 875                 880
 Leu Asn Arg Glu Leu Arg Ala Met Leu Ala Ile Glu Asp Trp Gln Lys
                 885                 890                 895    
 Thr Glu Ala Gln Lys Arg Arg Glu Gln Leu Leu Leu Asp Glu Leu Val
             900                 905                 910        
 Ala Leu Val Asn Lys Arg Asp Ala Leu Val Arg Asp Leu Asp Ala Gln
         915                 920                 925            
 Glu Lys Gln Ala Glu Glu Glu Asp Glu His Leu Glu Arg Thr Leu Glu
     930                 935                 940                
 Gln Asn Lys Gly Lys Met Ala Lys Lys Glu Glu Lys Cys Val Leu Gln
 945                 950                 955                 960





      <210> 964
      <211> 490
      <212> PRT
      <213> Homo sapiens


      <400> 964
 Met Asn Pro Gln Ile Arg Asn Pro Met Glu Arg Met Tyr Arg Asp Thr
   1               5                  10                  15    
 Phe Tyr Asp Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr
              20                  25                  30        
 Thr Trp Leu Cys Tyr Glu Val Lys Ile Lys Arg Gly Arg Ser Asn Leu
          35                  40                  45            
 Leu Trp Asp Thr Gly Val Phe Arg Gly Gln Val Tyr Phe Glu Pro Gln
      50                  55                  60                
 Tyr His Ala Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu
  65                  70                  75                  80
 Pro Ala Tyr Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr Pro
                  85                  90                  95    
 Cys Leu Asp Cys Val Ala Lys Leu Ala Glu Phe Leu Ser Glu His Pro
             100                 105                 110        
 Asn Val Thr Leu Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu
         115                 120                 125            
 Arg Asp Tyr Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg
     130                 135                 140                
 Val Thr Ile Met Asp Tyr Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe
 145                 150                 155                 160
 Val Tyr Asn Glu Gly Gln Gln Phe Met Pro Trp Tyr Lys Phe Asp Glu
                 165                 170                 175    
 Asn Tyr Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu Arg Tyr Leu
             180                 185                 190        
 Met Asp Pro Asp Thr Phe Thr Phe Asn Phe Asn Asn Asp Pro Leu Val
         195                 200                 205            
 Leu Arg Arg Arg Gln Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp
     210                 215                 220                
 Asn Gly Thr Trp Val Leu Met Asp Gln His Met Gly Phe Leu Cys Asn
 225                 230                 235                 240
 Glu Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu
                 245                 250                 255    
 Arg Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile
             260                 265                 270        
 Tyr Arg Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly
         275                 280                 285            
 Cys Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val Arg
     290                 295                 300                
 Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys
 305                 310                 315                 320
 Glu Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile Met
                 325                 330                 335    
 Thr Tyr Asp Glu Phe Glu Tyr Cys Trp Asp Thr Phe Val Tyr Arg Gln
             340                 345                 350        
 Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Glu Glu His Ser Gln Ala
         355                 360                 365            
 Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Val Arg Ala Ser Ser Leu
     370                 375                 380                
 Cys Leu Val Pro His Arg Pro Pro Pro Pro Pro Arg Ser Pro Val Pro
 385                 390                 395                 400
 Cys Leu Pro Leu Cys Ser Glu Pro Pro Leu Gly Ser Leu Leu Pro Thr
                 405                 410                 415    
 Gly Arg Pro Ala Pro Ser Leu Pro Phe Leu Leu Thr Ala Ser Phe Ser
             420                 425                 430        
 Phe Pro Pro Pro Ala Ser Leu Pro Pro Leu Pro Ser Leu Ser Leu Ser
         435                 440                 445            
 Pro Gly His Leu Pro Val Pro Ser Phe His Ser Leu Thr Ser Cys Ser
     450                 455                 460                
 Ile Gln Pro Pro Cys Ser Ser Arg Ile Arg Glu Thr Glu Gly Trp Ala
 465                 470                 475                 480
 Ser Val Ser Lys Glu Gly Arg Asp Leu Gly
                 485                 490



      <210> 965
      <211> 422
      <212> PRT
      <213> Homo sapiens


      <400> 965
 Met Ala Thr Gly Asp Glu Arg Phe Tyr Ala Glu His Leu Met Pro Thr
   1               5                  10                  15    
 Leu Gln Gly Leu Leu Asp Pro Glu Ser Ala His Arg Leu Ala Val Arg
              20                  25                  30        
 Phe Thr Ser Leu Gly Leu Leu Pro Arg Ala Arg Phe Gln Asp Ser Asp
          35                  40                  45            
 Met Leu Val Val Leu Pro Asp Thr Leu Tyr Ile Lys Tyr Lys Gly Glu
      50                  55                  60                
 Gly Cys Ser Pro Leu Asn Phe Ser Ala Gly Thr Asp Leu Phe Glu Asn
  65                  70                  75                  80
 Gln Asn Pro Lys Ile Arg Pro Cys Ser Pro Arg Glu Ala Phe Ala Ser
                  85                  90                  95    
 Leu Leu Lys Gly Arg Trp Ser Pro Ser Glu Val Arg Val Leu Gly His
             100                 105                 110        
 Lys Phe Arg Asn Pro Val Gly Ile Ala Ala Gly Phe Asp Lys His Gly
         115                 120                 125            
 Glu Ala Val Asp Gly Leu Tyr Lys Met Gly Phe Gly Phe Val Glu Ile
     130                 135                 140                
 Gly Ser Val Thr Pro Lys Pro Gln Glu Gly Asn Pro Arg Pro Arg Val
 145                 150                 155                 160
 Phe Arg Leu Pro Glu Asp Gln Ala Val Ile Asn Arg Tyr Gly Phe Asn
                 165                 170                 175    
 Ser His Gly Leu Ser Val Val Glu His Arg Leu Arg Ala Arg Gln Gln
             180                 185                 190        
 Lys Gln Ala Lys Leu Thr Glu Asp Gly Leu Pro Leu Gly Val Asn Leu
         195                 200                 205            
 Gly Lys Asn Lys Thr Ser Val Asp Ala Ala Glu Asp Tyr Ala Glu Gly
     210                 215                 220                
 Val Arg Val Leu Gly Pro Leu Ala Asp Tyr Leu Val Val Asn Val Ser
 225                 230                 235                 240
 Ser Pro Asn Thr Ala Gly Leu Arg Ser Leu Gln Gly Lys Ala Glu Leu
                 245                 250                 255    
 Arg Arg Leu Leu Thr Lys Val Leu Gln Glu Arg Asp Gly Leu Arg Arg
             260                 265                 270        
 Val His Arg Pro Ala Val Leu Val Lys Ile Ala Pro Asp Leu Thr Ser
         275                 280                 285            
 Gln Asp Lys Glu Asp Ile Ala Ser Val Val Lys Glu Leu Gly Ile Asp
     290                 295                 300                
 Gly Leu Ile Val Thr Asn Thr Thr Val Ser Arg Pro Ala Gly Leu Gln
 305                 310                 315                 320
 Gly Ala Leu Arg Ser Glu Thr Gly Gly Leu Ser Gly Lys Pro Leu Arg
                 325                 330                 335    
 Asp Leu Ser Thr Gln Thr Ile Arg Glu Met Tyr Ala Leu Thr Gln Gly
             340                 345                 350        
 Arg Val Pro Ile Ile Gly Val Gly Gly Val Ser Ser Gly Gln Asp Ala
         355                 360                 365            
 Leu Glu Lys Ile Arg Ala Gly Ala Ser Leu Val Gln Leu Tyr Thr Ala
     370                 375                 380                
 Leu Thr Phe Trp Gly Pro Pro Val Val Gly Lys Val Lys Arg Glu Leu
 385                 390                 395                 400
 Glu Ala Leu Leu Lys Glu Gln Gly Phe Gly Gly Val Thr Asp Ala Ile
                 405                 410                 415    
 Gly Ala Asp His Arg Arg
             420        



      <210> 966
      <211> 490
      <212> PRT
      <213> Homo sapiens


      <400> 966
 Met Leu Ser Asp Gly Cys Gly Ser Glu Glu Lys Ile Ser Val Pro Ser
   1               5                  10                  15    
 Cys Tyr Gly Gly Ile Gly Ala Pro Val Ser Arg Gln Val Pro Ala Ser
              20                  25                  30        
 His Asp Ser Glu Leu Met Ala Phe Met Thr Arg Lys Leu Trp Asp Leu
          35                  40                  45            
 Glu Gln Gln Val Lys Ala Gln Thr Asp Glu Ile Leu Ser Lys Asp Gln
      50                  55                  60                
 Lys Ile Ala Ala Leu Glu Asp Leu Val Gln Thr Leu Arg Pro His Pro
  65                  70                  75                  80
 Ala Glu Ala Thr Leu Gln Arg Gln Glu Glu Leu Glu Thr Met Cys Val
                  85                  90                  95    
 Gln Leu Gln Arg Gln Val Arg Glu Met Glu Arg Phe Leu Ser Asp Tyr
             100                 105                 110        
 Gly Leu Gln Trp Val Gly Glu Pro Met Asp Gln Glu Asp Ser Glu Ser
         115                 120                 125            
 Lys Thr Val Ser Glu His Gly Glu Arg Asp Trp Met Thr Ala Lys Lys
     130                 135                 140                
 Phe Trp Lys Pro Gly Asp Ser Leu Ala Pro Pro Glu Val Asp Phe Asp
 145                 150                 155                 160
 Arg Leu Leu Ala Ser Leu Gln Asp Leu Ser Glu Leu Val Val Glu Gly
                 165                 170                 175    
 Asp Thr Gln Val Thr Pro Val Pro Gly Gly Ala Arg Leu Arg Thr Leu
             180                 185                 190        
 Glu Pro Ile Pro Leu Lys Leu Tyr Arg Asn Gly Ile Met Met Phe Asp
         195                 200                 205            
 Gly Pro Phe Gln Pro Phe Tyr Asp Pro Ser Thr Gln Arg Cys Leu Arg
     210                 215                 220                
 Asp Ile Leu Asp Gly Phe Phe Pro Ser Glu Leu Gln Arg Leu Tyr Pro
 225                 230                 235                 240
 Asn Gly Val Pro Phe Lys Val Ser Asp Leu Arg Asn Gln Val Tyr Leu
                 245                 250                 255    
 Glu Asp Gly Leu Asp Pro Phe Pro Gly Glu Gly Arg Val Val Gly Arg
             260                 265                 270        
 Gln Leu Met His Lys Ala Leu Asp Arg Val Glu Glu His Pro Gly Ser
         275                 280                 285            
 Arg Met Thr Ala Glu Lys Phe Leu Asn Arg Leu Pro Lys Phe Val Ile
     290                 295                 300                
 Arg Gln Gly Glu Val Ile Asp Ile Arg Gly Pro Ile Arg Asp Thr Leu
 305                 310                 315                 320
 Gln Asn Cys Cys Pro Leu Pro Ala Arg Ile Gln Glu Ile Val Val Glu
                 325                 330                 335    
 Thr Pro Thr Leu Ala Ala Glu Arg Glu Arg Ser Gln Glu Ser Pro Asn
             340                 345                 350        
 Thr Pro Ala Pro Pro Leu Ser Met Leu Arg Ile Lys Ser Glu Asn Gly
         355                 360                 365            
 Glu Gln Ala Phe Leu Leu Met Met Gln Pro Asp Asn Thr Ile Gly Asp
     370                 375                 380                
 Val Arg Ala Leu Leu Ala Gln Ala Arg Val Met Asp Ala Ser Ala Phe
 385                 390                 395                 400
 Glu Ile Phe Ser Thr Phe Pro Pro Thr Leu Tyr Gln Asp Asp Thr Leu
                 405                 410                 415    
 Thr Leu Gln Ala Ala Gly Leu Val Pro Lys Ala Ala Leu Leu Leu Arg
             420                 425                 430        
 Ala Arg Arg Ala Pro Lys Ser Ser Leu Lys Phe Ser Pro Gly Pro Cys
         435                 440                 445            
 Pro Gly Pro Gly Pro Gly Pro Ser Pro Gly Pro Gly Pro Gly Pro Ser
     450                 455                 460                
 Pro Gly Pro Gly Pro Gly Pro Ser Pro Gly Pro Gly Pro Gly Pro Ser
 465                 470                 475                 480
 Pro Cys Pro Gly Pro Ser Pro Ser Pro Gln
                 485                 490



      <210> 967
      <211> 55
      <212> PRT
      <213> Homo sapiens


      <400> 967
 Met Ser Leu Leu Gly His Gln Glu Gly Thr Gln Asp Leu Ser Glu Leu
   1               5                  10                  15    
 Trp Asn Arg Pro Ser Tyr Ser Gly Ala Arg Ser Leu Pro Arg Lys Gln
              20                  25                  30        
 Gln Val Ala Leu Pro Gly Cys Arg Ala Gln Leu Ile Gly Cys Pro Trp
          35                  40                  45            
 Ala Ser Ser Pro Ser Ser Glu
      50                  55



      <210> 968
      <211> 999
      <212> PRT
      <213> Homo sapiens


      <400> 968
 Met Glu Glu Lys Pro Ser Gly Pro Ile Pro Asp Met Leu Ala Thr Ala
   1               5                  10                  15    
 Glu Pro Ser Ser Ser Glu Thr Asp Lys Glu Val Leu Ser Pro Ala Val
              20                  25                  30        
 Pro Ala Ala Ala Pro Ser Ser Ser Met Ser Glu Glu Pro Gly Pro Glu
          35                  40                  45            
 Gln Ala Ala Thr Pro Pro Val Trp Glu Arg Gly Gly Ala Gly Gly Met
      50                  55                  60                
 Gln Gln Gly Ser Ser Pro Ala Pro Asp Ser Cys Gln Pro Gly Pro Gly
  65                  70                  75                  80
 Pro Ser Pro Gly Leu Thr Ser Ile Val Ser Gly Thr Ser Glu Asp Leu
                  85                  90                  95    
 Arg Pro Pro Arg Arg Arg Pro Pro Pro Gly Lys Gln Ile Pro Cys Ser
             100                 105                 110        
 Ser Pro Gly Cys Cys Leu Ser Phe Pro Ser Val Arg Asp Leu Ala Gln
         115                 120                 125            
 His Leu Arg Thr His Cys Pro Pro Thr Gln Ser Leu Glu Gly Lys Leu
     130                 135                 140                
 Phe Arg Cys Ser Ala Leu Ser Cys Thr Glu Thr Phe Pro Ser Met Gln
 145                 150                 155                 160
 Glu Leu Val Ala His Ser Lys Leu His Tyr Lys Pro Asn Arg Tyr Phe
                 165                 170                 175    
 Lys Cys Glu Asn Cys Leu Leu Arg Phe Arg Thr His Arg Ser Leu Phe
             180                 185                 190        
 Lys His Leu His Val Cys Ala Glu His Ala Gln Ser Pro Ala Pro Pro
         195                 200                 205            
 Pro Pro Pro Ala Leu Asp Arg Glu Pro Pro Ala Pro Glu Arg Pro Pro
     210                 215                 220                
 Glu Val Asp Pro Ala Ser Ala Pro Gly Leu Pro Phe Pro Leu Leu Glu
 225                 230                 235                 240
 Pro Phe Thr Thr Pro Ala Pro Ala Pro Thr Gly Pro Phe Leu Pro Tyr
                 245                 250                 255    
 Leu Asn Pro Ala Pro Phe Gly Leu Ser Pro Pro Arg Leu Arg Pro Phe
             260                 265                 270        
 Leu Ala Ala Ala Pro Gly Pro Pro Ala Ser Ser Ala Ala Val Trp Lys
         275                 280                 285            
 Lys Ser Gln Gly Ala Gly Ser Ser Pro Arg Arg Pro Gln Gly Gly Ser
     290                 295                 300                
 Asp Ala Pro Ser Gly His Ala Ala Pro Ser Arg Ile Val Trp Glu His
 305                 310                 315                 320
 Thr Arg Gly Arg Tyr Ser Cys Met Gln Cys Ala Phe Ser Thr Ala Ser
                 325                 330                 335    
 Arg Pro Ala Met Thr Leu His Leu Glu Asp His Arg Pro Gly Ala Pro
             340                 345                 350        
 Ala Ala Pro Ala Pro Gly Pro Pro Arg Pro Asp Ala Pro Ala Gly Ser
         355                 360                 365            
 Arg Gly Pro Pro Gly Val Phe Val Pro Ile Ser Phe Phe Ile Arg Pro
     370                 375                 380                
 Pro Pro Asp Leu Gly His Ala Ser Ser Gln Ser Val Ser Ile Phe Pro
 385                 390                 395                 400
 Glu Lys Pro Arg Ala Asn Thr Ser Val Gln Gly Pro Leu Pro Tyr Pro
                 405                 410                 415    
 Ile Thr His Gly Asp Gly Thr Ala Leu Pro Lys Arg Pro Pro Thr Leu
             420                 425                 430        
 Lys Pro Ala Pro Asn Pro His Ala Gln Glu Pro Ser Pro Leu Gly Pro
         435                 440                 445            
 Arg Leu Arg Pro Ala Gly Gly Ala Leu Glu Ser Gln Thr Arg Gly Asn
     450                 455                 460                
 Glu Ser Arg Glu Ser Ser Gly Asp Ser Gly Gln Gln Pro Pro Pro Cys
 465                 470                 475                 480
 Val Leu Thr Val Glu Gln Lys Pro Gln Ser Leu Pro Glu Gly Ser Gly
                 485                 490                 495    
 Pro Ser Ser Gly Pro Thr His Pro Met Ala His His Leu Pro Ala Ala
             500                 505                 510        
 Met Glu Ser His Gln Asp Phe Arg Ser Ile Lys Ala Lys Phe Gln Ala
         515                 520                 525            
 Ser Gln Pro Glu Pro Ser Asp Leu Pro Lys Lys Pro Pro Lys Pro Glu
     530                 535                 540                
 Phe Gly Lys Leu Lys Lys Phe Ser Gln Pro Glu Leu Ser Glu His Pro
 545                 550                 555                 560
 Lys Lys Ala Pro Leu Pro Glu Phe Gly Ala Val Ser Leu Lys Pro Pro
                 565                 570                 575    
 Pro Pro Glu Val Thr Asp Leu Pro Lys Lys Pro Pro Pro Pro Glu Val
             580                 585                 590        
 Thr Asp Leu Pro Lys Lys Pro Pro Pro Pro Glu Val Thr Asp Leu Pro
         595                 600                 605            
 Lys Lys Pro Pro Pro Pro Glu Val Thr Asp Leu Pro Lys Lys Pro Ser
     610                 615                 620                
 Lys Leu Glu Leu Ser Asp Leu Ser Lys Lys Phe Pro Gln Leu Gly Ala
 625                 630                 635                 640
 Thr Pro Phe Pro Arg Lys Pro Leu Gln Pro Glu Val Gly Glu Ala Pro
                 645                 650                 655    
 Leu Lys Ala Ser Leu Pro Glu Pro Gly Ala Pro Ala Arg Lys Pro Leu
             660                 665                 670        
 Gln Pro Asp Glu Leu Ser His Pro Ala Arg Pro Pro Ser Glu Pro Lys
         675                 680                 685            
 Ser Gly Ala Phe Pro Arg Lys Leu Trp Gln Pro Glu Ala Gly Glu Ala
     690                 695                 700                
 Thr Pro Arg Ser Pro Gln Pro Glu Leu Ser Thr Phe Pro Lys Lys Pro
 705                 710                 715                 720
 Ala Gln Pro Glu Phe Asn Val Tyr Pro Lys Lys Pro Pro Gln Pro Gln
                 725                 730                 735    
 Val Gly Gly Leu Pro Lys Lys Ser Val Pro Gln Pro Glu Phe Ser Glu
             740                 745                 750        
 Ala Ala Gln Thr Pro Leu Trp Lys Pro Gln Ser Ser Glu Pro Lys Arg
         755                 760                 765            
 Asp Ser Ser Ala Phe Pro Lys Lys Ala Ser Gln Pro Pro Leu Ser Asp
     770                 775                 780                
 Phe Pro Lys Lys Pro Pro Gln Pro Glu Leu Gly Asp Leu Thr Arg Thr
 785                 790                 795                 800
 Ser Ser Glu Pro Glu Val Ser Val Leu Pro Lys Arg Pro Arg Pro Ala
                 805                 810                 815    
 Glu Phe Lys Ala Leu Ser Lys Lys Pro Pro Gln Pro Glu Leu Gly Gly
             820                 825                 830        
 Leu Pro Arg Thr Ser Ser Glu Pro Glu Phe Asn Ser Leu Pro Arg Lys
         835                 840                 845            
 Leu Leu Gln Pro Glu Arg Arg Gly Pro Pro Arg Lys Phe Ser Gln Pro
     850                 855                 860                
 Glu Pro Ser Ala Val Leu Lys Arg His Pro Gln Pro Glu Phe Phe Gly
 865                 870                 875                 880
 Asp Leu Pro Arg Lys Pro Pro Leu Pro Ser Ser Ala Ser Glu Ser Ser
                 885                 890                 895    
 Leu Pro Ala Ala Val Ala Gly Phe Ser Ser Arg His Pro Leu Ser Pro
             900                 905                 910        
 Gly Phe Gly Ala Ala Gly Thr Pro Arg Trp Arg Ser Gly Gly Leu Val
         915                 920                 925            
 His Ser Gly Gly Ala Arg Pro Gly Leu Arg Pro Ser His Pro Pro Arg
     930                 935                 940                
 Arg Arg Pro Leu Pro Pro Ala Ser Ser Leu Gly His Pro Pro Ala Lys
 945                 950                 955                 960
 Pro Pro Leu Pro Pro Gly Pro Val Asp Met Gln Ser Phe Arg Arg Pro
                 965                 970                 975    
 Ser Ala Ala Ser Ile Asp Leu Arg Arg Thr Arg Ser Ala Ala Gly Leu
             980                 985                 990        
 His Tyr Pro Gly Pro Thr Ala
         995                



      <210> 969
      <211> 135
      <212> PRT
      <213> Homo sapiens


      <400> 969
 Met Asn His Thr Val Gln Thr Phe Phe Ser Pro Val Asn Ser Gly Gln
   1               5                  10                  15    
 Pro Pro Asn Tyr Glu Met Leu Lys Glu Glu His Glu Val Ala Val Leu
              20                  25                  30        
 Gly Ala Pro His Asn Pro Ala Pro Pro Thr Ser Thr Val Ile His Ile
          35                  40                  45            
 Arg Ser Glu Thr Ser Val Pro Asp His Val Val Trp Ser Leu Phe Asn
      50                  55                  60                
 Thr Leu Phe Met Asn Pro Cys Cys Leu Gly Phe Ile Ala Phe Ala Tyr
  65                  70                  75                  80
 Ser Val Lys Val Arg Met Ala Pro Gly Asn Ala Gln Arg Val Pro Leu
                  85                  90                  95    
 Ser Leu Glu Leu His Leu Pro Thr Cys Cys Leu Gly Trp Gly Leu Val
             100                 105                 110        
 Cys Pro Cys Asp Cys Glu Phe Val Cys Thr Ser Val Pro Cys Val Pro
         115                 120                 125            
 Thr Ser Val Ala Leu Ser Val
     130                 135



      <210> 970
      <211> 314
      <212> PRT
      <213> Homo sapiens


      <400> 970
 Met Thr Ser Gln Glu Lys Thr Glu Glu Tyr Pro Phe Ala Asp Ile Phe
   1               5                  10                  15    
 Asp Glu Asp Glu Thr Glu Arg Asn Phe Leu Leu Ser Lys Pro Val Cys
              20                  25                  30        
 Phe Val Val Phe Gly Lys Pro Gly Val Gly Lys Thr Thr Leu Ala Arg
          35                  40                  45            
 Tyr Ile Thr Gln Ala Trp Lys Cys Ile Arg Val Glu Ala Leu Pro Ile
      50                  55                  60                
 Leu Glu Glu Gln Ile Ala Ala Glu Thr Glu Ser Gly Val Met Leu Gln
  65                  70                  75                  80
 Ser Met Leu Ile Ser Gly Gln Ser Ile Pro Asp Glu Leu Val Ile Lys
                  85                  90                  95    
 Leu Met Leu Glu Lys Leu Asn Ser Pro Glu Val Cys His Phe Gly Tyr
             100                 105                 110        
 Ile Ile Thr Glu Ile Pro Ser Leu Ser Gln Asp Ala Met Thr Thr Leu
         115                 120                 125            
 Gln Gln Ile Glu Leu Ile Lys Asn Leu Asn Leu Lys Pro Asp Val Ile
     130                 135                 140                
 Ile Asn Ile Lys Cys Pro Asp Tyr Asp Leu Cys Gln Arg Ile Ser Gly
 145                 150                 155                 160
 Gln Arg Gln His Asn Asn Thr Gly Tyr Ile Tyr Ser Arg Asp Gln Trp
                 165                 170                 175    
 Asp Pro Glu Val Ile Glu Asn His Arg Lys Lys Lys Lys Glu Ala Gln
             180                 185                 190        
 Lys Asp Gly Lys Gly Glu Glu Glu Glu Glu Glu Glu Glu Gln Glu Glu
         195                 200                 205            
 Glu Glu Ala Phe Ile Ala Glu Met Gln Met Val Ala Glu Ile Leu His
     210                 215                 220                
 His Leu Val Gln Arg Pro Glu Asp Tyr Leu Glu Asn Val Glu Asn Ile
 225                 230                 235                 240
 Val Lys Leu Tyr Lys Glu Thr Ile Leu Gln Thr Leu Glu Glu Val Met
                 245                 250                 255    
 Ala Glu His Asn Pro Gln Tyr Leu Ile Glu Leu Asn Gly Asn Lys Pro
             260                 265                 270        
 Ala Glu Glu Leu Phe Met Val Ser Ala Val Leu Ser Arg Asn Thr Ser
         275                 280                 285            
 Gln His Gly Lys Phe Lys Ser Ile Asp Ser Ile Val Leu Leu Leu Ile
     290                 295                 300                
 Asn Arg Ser Ile Phe Ile Phe Glu His His
 305                 310                



      <210> 971
      <211> 897
      <212> PRT
      <213> Homo sapiens


      <400> 971
 Met Trp Lys Lys Asp Asn Lys Thr Gln Arg Asn Lys Ser Cys Ile Thr
   1               5                  10                  15    
 Leu Arg Asp Val Lys Glu Glu Cys Arg Phe Met Gly Val Cys Phe Ile
              20                  25                  30        
 Pro Tyr Gly Ile Pro Thr Thr Leu Ser Cys Ala Trp His Val Gly Ser
          35                  40                  45            
 Asn Asp Trp Gly Leu Val Val Thr Leu Leu Phe Gly Lys Thr Asn Ser
      50                  55                  60                
 Glu Lys Tyr Leu Glu Gln Cys Glu His Ser Phe Leu Pro Pro Thr Ser
  65                  70                  75                  80
 Pro Gly Val Pro Lys Cys Leu Glu Glu Met Lys Arg Glu Ala Arg Thr
                  85                  90                  95    
 Ile Lys Ile Asp Arg Arg Leu Thr Gly Ala Asn Ile Ile Asp Glu Pro
             100                 105                 110        
 Leu Gln Gln Val Ile Gln Phe Ser Leu Arg Asp Tyr Val Gln Tyr Trp
         115                 120                 125            
 Tyr Tyr Thr Leu Ser Asp Asp Glu Ser Phe Leu Leu Glu Ile Arg Gln
     130                 135                 140                
 Thr Leu Gln Asn Ala Leu Ile Gln Phe Ala Thr Arg Ser Lys Glu Ile
 145                 150                 155                 160
 Asp Trp Gln Pro Tyr Phe Thr Thr Arg Ile Val Asp Asp Phe Gly Thr
                 165                 170                 175    
 His Leu Arg Val Phe Arg Lys Ala Gln Gln Lys Ile Thr Glu Lys Asp
             180                 185                 190        
 Asp Gln Val Lys Gly Thr Ala Glu Asp Leu Val Asp Thr Phe Phe Glu
         195                 200                 205            
 Val Glu Val Glu Met Glu Lys Glu Val Cys Arg Asp Leu Val Cys Thr
     210                 215                 220                
 Ser Pro Lys Asp Glu Glu Gly Phe Leu Arg Asp Leu Cys Glu Val Leu
 225                 230                 235                 240
 Leu Tyr Leu Leu Leu Pro Pro Gly Asp Phe Gln Asn Lys Ile Met Arg
                 245                 250                 255    
 Tyr Phe Val Arg Glu Ile Leu Ala Arg Gly Ile Leu Leu Pro Leu Ile
             260                 265                 270        
 Asn Gln Leu Ser Asp Pro Asp Tyr Ile Asn Gln Tyr Val Ile Trp Met
         275                 280                 285            
 Ile Arg Asp Ser Asn Cys Asn Tyr Glu Ala Phe Met Asn Ile Ile Lys
     290                 295                 300                
 Leu Ser Asp Asn Ile Gly Glu Leu Glu Ala Val Arg Asp Lys Ala Ala
 305                 310                 315                 320
 Glu Glu Leu Gln Tyr Leu Arg Ser Leu Asp Thr Ala Gly Asp Asp Ile
                 325                 330                 335    
 Asn Thr Ile Lys Asn Gln Ile Asn Ser Leu Leu Phe Val Lys Lys Val
             340                 345                 350        
 Cys Asp Ser Arg Ile Gln Arg Leu Gln Ser Gly Lys Glu Ile Asn Thr
         355                 360                 365            
 Val Lys Leu Ala Ala Asn Phe Gly Lys Leu Cys Thr Val Pro Leu Asp
     370                 375                 380                
 Ser Ile Leu Val Asp Asn Val Ala Leu Gln Phe Phe Met Asp Tyr Met
 385                 390                 395                 400
 Gln Gln Thr Gly Gly Gln Ala His Leu Phe Phe Trp Met Thr Val Glu
                 405                 410                 415    
 Gly Tyr Arg Val Thr Ala Gln Gln Gln Leu Glu Val Leu Leu Ser Arg
             420                 425                 430        
 Gln Arg Asp Gly Lys His Gln Thr Asn Gln Thr Lys Gly Leu Leu Arg
         435                 440                 445            
 Ala Ala Ala Val Gly Ile Tyr Glu Gln Tyr Leu Ser Glu Lys Ala Ser
     450                 455                 460                
 Pro Arg Val Thr Val Asp Asp Tyr Leu Val Ala Lys Leu Ala Asp Thr
 465                 470                 475                 480
 Leu Asn His Glu Asp Pro Thr Pro Glu Ile Phe Asp Asp Ile Gln Arg
                 485                 490                 495    
 Lys Val Tyr Glu Leu Met Leu Arg Asp Glu Arg Phe Tyr Pro Ser Phe
             500                 505                 510        
 Arg Gln Asn Ala Leu Tyr Val Arg Met Leu Ala Glu Leu Asp Met Leu
         515                 520                 525            
 Lys Asp Pro Ser Phe Arg Gly Ser Asp Asp Gly Asp Gly Glu Ser Phe
     530                 535                 540                
 Asn Gly Ser Pro Thr Gly Ser Ile Asn Leu Ser Leu Asp Asp Leu Ser
 545                 550                 555                 560
 Asn Val Ser Ser Asp Asp Ser Val Gln Leu His Ala Tyr Ile Ser Asp
                 565                 570                 575    
 Thr Val Tyr Ala Asp Tyr Asp Pro Tyr Ala Val Ala Gly Val Cys Asn
             580                 585                 590        
 Asp His Gly Lys Thr Tyr Ala Leu Tyr Ala Ile Thr Val His Arg Arg
         595                 600                 605            
 Asn Leu Asn Ser Glu Glu Met Trp Lys Thr Tyr Arg Arg Tyr Ser Asp
     610                 615                 620                
 Phe His Asp Phe His Met Arg Ile Thr Glu Gln Phe Glu Ser Leu Ser
 625                 630                 635                 640
 Ser Ile Leu Lys Leu Pro Gly Lys Lys Thr Phe Asn Asn Met Asp Arg
                 645                 650                 655    
 Asp Phe Leu Glu Lys Arg Lys Lys Asp Leu Asn Ala Tyr Leu Gln Leu
             660                 665                 670        
 Leu Leu Ala Pro Glu Met Met Lys Ala Ser Pro Ala Leu Ala His Tyr
         675                 680                 685            
 Val Tyr Asp Phe Leu Glu Asn Lys Ala Tyr Ser Lys Gly Lys Gly Asp
     690                 695                 700                
 Phe Ala Arg Lys Met Asp Thr Phe Val Asn Pro Leu Arg Asn Ser Met
 705                 710                 715                 720
 Arg Asn Val Ser Asn Ala Val Lys Ser Leu Pro Asp Ser Leu Ala Glu
                 725                 730                 735    
 Gly Met Thr Lys Met Ser Asp Asn Met Gly Lys Met Ser Glu Arg Leu
             740                 745                 750        
 Gly Gln Asp Ile Lys Gln Ser Phe Phe Lys Val Pro Pro Leu Ile Pro
         755                 760                 765            
 Lys Thr Asp Ser Asp Pro Glu His Arg Arg Val Ser Ala Gln Leu Asp
     770                 775                 780                
 Asp Asn Val Asp Asp Asn Ile Pro Leu Arg Val Met Leu Leu Leu Met
 785                 790                 795                 800
 Asp Glu Val Phe Asp Leu Lys Glu Arg Asn Gln Trp Leu Arg Arg Asn
                 805                 810                 815    
 Ile Lys Asn Leu Leu Gln Gln Leu Ile Arg Ala Thr Tyr Gly Asp Thr
             820                 825                 830        
 Ile Asn Arg Lys Ile Val Asp His Val Asp Trp Met Thr Ser Pro Glu
         835                 840                 845            
 Gln Val Ala Asp Ser Val Lys Arg Phe Arg Asp Ala Phe Trp Pro Asn
     850                 855                 860                
 Gly Ile Leu Ala Glu Ala Val Pro Cys Arg Asp Lys Ser Ile Arg Met
 865                 870                 875                 880
 Arg Thr Arg Val Ala Gly Lys Thr Lys Leu Leu Ala Ile Met Pro Gly
                 885                 890                 895    
 Glu
    



      <210> 972
      <211> 886
      <212> PRT
      <213> Homo sapiens


      <400> 972
 Met Trp Lys Lys Asp Asn Lys Thr Gln Arg Asn Lys Ser Cys Ile Thr
   1               5                  10                  15    
 Leu Arg Asp Val Lys Glu Glu Cys Arg Phe Met Gly Val Cys Phe Ile
              20                  25                  30        
 Pro Tyr Gly Ile Pro Thr Thr Leu Ser Cys Ala Trp His Val Gly Ser
          35                  40                  45            
 Asn Asp Trp Gly Leu Val Val Thr Leu Leu Phe Gly Lys Thr Asn Ser
      50                  55                  60                
 Glu Lys Tyr Leu Glu Gln Cys Glu His Ser Phe Leu Pro Pro Thr Ser
  65                  70                  75                  80
 Pro Gly Val Pro Lys Cys Leu Glu Glu Met Lys Arg Glu Ala Arg Thr
                  85                  90                  95    
 Ile Lys Ile Asp Arg Arg Leu Thr Gly Ala Asn Ile Ile Asp Glu Pro
             100                 105                 110        
 Leu Gln Gln Val Ile Gln Phe Ser Leu Arg Asp Tyr Val Gln Tyr Trp
         115                 120                 125            
 Tyr Tyr Thr Leu Ser Asp Asp Glu Ser Phe Leu Leu Glu Ile Arg Gln
     130                 135                 140                
 Thr Leu Gln Asn Ala Leu Ile Gln Phe Ala Thr Arg Ser Lys Glu Ile
 145                 150                 155                 160
 Asp Trp Gln Pro Tyr Phe Thr Thr Arg Ile Val Asp Asp Phe Gly Thr
                 165                 170                 175    
 His Leu Arg Val Phe Arg Lys Ala Gln Gln Lys Ile Thr Glu Lys Asp
             180                 185                 190        
 Asp Gln Val Lys Gly Thr Ala Glu Asp Leu Val Asp Thr Phe Phe Glu
         195                 200                 205            
 Val Glu Val Glu Met Glu Lys Glu Val Cys Arg Asp Leu Val Cys Thr
     210                 215                 220                
 Ser Pro Lys Asp Glu Glu Gly Phe Leu Arg Asp Leu Cys Glu Val Leu
 225                 230                 235                 240
 Leu Tyr Leu Leu Leu Pro Pro Gly Asp Phe Gln Asn Lys Ile Met Arg
                 245                 250                 255    
 Tyr Phe Val Arg Glu Ile Leu Ala Arg Gly Ile Leu Leu Pro Leu Ile
             260                 265                 270        
 Asn Gln Leu Ser Asp Pro Asp Tyr Ile Asn Gln Tyr Val Ile Trp Met
         275                 280                 285            
 Ile Arg Asp Ser Asn Cys Asn Tyr Glu Ala Phe Met Asn Ile Ile Lys
     290                 295                 300                
 Leu Ser Asp Asn Ile Gly Glu Leu Glu Ala Val Arg Asp Lys Ala Ala
 305                 310                 315                 320
 Glu Glu Leu Gln Tyr Leu Arg Ser Leu Asp Thr Ala Gly Asp Asp Ile
                 325                 330                 335    
 Asn Thr Ile Lys Asn Gln Ile Asn Ser Leu Leu Phe Val Lys Lys Val
             340                 345                 350        
 Cys Asp Ser Arg Ile Gln Arg Leu Gln Ser Gly Lys Glu Ile Asn Thr
         355                 360                 365            
 Val Lys Leu Ala Ala Asn Phe Gly Lys Leu Cys Thr Val Pro Leu Asp
     370                 375                 380                
 Ser Ile Leu Val Asp Asn Val Ala Leu Gln Phe Phe Met Asp Tyr Met
 385                 390                 395                 400
 Gln Gln Thr Gly Gly Gln Ala His Leu Phe Phe Trp Met Thr Val Glu
                 405                 410                 415    
 Gly Tyr Arg Val Thr Ala Gln Gln Gln Leu Glu Val Leu Leu Ser Arg
             420                 425                 430        
 Gln Arg Asp Gly Lys His Gln Thr Asn Gln Thr Lys Gly Leu Leu Arg
         435                 440                 445            
 Ala Ala Ala Val Gly Ile Tyr Glu Gln Tyr Leu Ser Glu Lys Ala Ser
     450                 455                 460                
 Pro Arg Val Thr Val Asp Asp Tyr Leu Val Ala Lys Leu Ala Asp Thr
 465                 470                 475                 480
 Leu Asn His Glu Asp Pro Thr Pro Glu Ile Phe Asp Asp Ile Gln Arg
                 485                 490                 495    
 Lys Val Tyr Glu Leu Met Leu Arg Asp Glu Arg Phe Tyr Pro Ser Phe
             500                 505                 510        
 Arg Gln Asn Ala Leu Tyr Val Arg Met Leu Ala Glu Leu Asp Met Leu
         515                 520                 525            
 Lys Asp Pro Ser Phe Arg Gly Ser Asp Asp Gly Asp Gly Glu Ser Phe
     530                 535                 540                
 Asn Gly Ser Pro Thr Gly Ser Ile Asn Leu Ser Leu Asp Asp Leu Ser
 545                 550                 555                 560
 Asn Val Ser Ser Asp Asp Ser Val Gln Leu His Ala Tyr Ile Ser Asp
                 565                 570                 575    
 Thr Gly Val Cys Asn Asp His Gly Lys Thr Tyr Ala Leu Tyr Ala Ile
             580                 585                 590        
 Thr Val His Arg Arg Asn Leu Asn Ser Glu Glu Met Trp Lys Thr Tyr
         595                 600                 605            
 Arg Arg Tyr Ser Asp Phe His Asp Phe His Met Arg Ile Thr Glu Gln
     610                 615                 620                
 Phe Glu Ser Leu Ser Ser Ile Leu Lys Leu Pro Gly Lys Lys Thr Phe
 625                 630                 635                 640
 Asn Asn Met Asp Arg Asp Phe Leu Glu Lys Arg Lys Lys Asp Leu Asn
                 645                 650                 655    
 Ala Tyr Leu Gln Leu Leu Leu Ala Pro Glu Met Met Lys Ala Ser Pro
             660                 665                 670        
 Ala Leu Ala His Tyr Val Tyr Asp Phe Leu Glu Asn Lys Ala Tyr Ser
         675                 680                 685            
 Lys Gly Lys Gly Asp Phe Ala Arg Lys Met Asp Thr Phe Val Asn Pro
     690                 695                 700                
 Leu Arg Asn Ser Met Arg Asn Val Ser Asn Ala Val Lys Ser Leu Pro
 705                 710                 715                 720
 Asp Ser Leu Ala Glu Gly Met Thr Lys Met Ser Asp Asn Met Gly Lys
                 725                 730                 735    
 Met Ser Glu Arg Leu Gly Gln Asp Ile Lys Gln Ser Phe Phe Lys Val
             740                 745                 750        
 Pro Pro Leu Ile Pro Lys Thr Asp Ser Asp Pro Glu His Arg Arg Val
         755                 760                 765            
 Ser Ala Gln Leu Asp Asp Asn Val Asp Asp Asn Ile Pro Leu Arg Val
     770                 775                 780                
 Met Leu Leu Leu Met Asp Glu Val Phe Asp Leu Lys Glu Arg Asn Gln
 785                 790                 795                 800
 Trp Leu Arg Arg Asn Ile Lys Asn Leu Leu Gln Gln Leu Ile Arg Ala
                 805                 810                 815    
 Thr Tyr Gly Asp Thr Ile Asn Arg Lys Ile Val Asp His Val Asp Trp
             820                 825                 830        
 Met Thr Ser Pro Glu Gln Val Ala Asp Ser Val Lys Arg Phe Arg Asp
         835                 840                 845            
 Ala Phe Trp Pro Asn Gly Ile Leu Ala Glu Ala Val Pro Cys Arg Asp
     850                 855                 860                
 Lys Ser Ile Arg Met Arg Thr Arg Val Ala Gly Lys Thr Lys Leu Leu
 865                 870                 875                 880
 Ala Ile Met Pro Gly Glu
                 885    



      <210> 973
      <211> 757
      <212> PRT
      <213> Homo sapiens


      <400> 973
 Met Ala Glu Val Gly Arg Thr Gly Ile Ser Tyr Pro Gly Ala Leu Leu
   1               5                  10                  15    
 Pro Gln Gly Phe Trp Ala Ala Val Glu Val Trp Leu Glu Arg Pro Gln
              20                  25                  30        
 Val Ala Asn Lys Arg Leu Cys Gly Ala Arg Leu Glu Ala Arg Trp Ser
          35                  40                  45            
 Ala Ala Leu Pro Cys Ala Glu Ala Arg Gly Pro Gly Thr Ser Ala Gly
      50                  55                  60                
 Ser Glu Gln Lys Glu Arg Gly Pro Gly Pro Gly Gln Gly Ser Pro Gly
  65                  70                  75                  80
 Gly Gly Pro Gly Pro Arg Ser Leu Ser Gly Pro Glu Gln Gly Thr Ala
                  85                  90                  95    
 Cys Cys Glu Leu Glu Glu Ala Gln Gly Gln Cys Gln Gln Glu Glu Ala
             100                 105                 110        
 Gln Arg Glu Ala Ala Ser Val Pro Leu Arg Asp Ser Gly His Pro Gly
         115                 120                 125            
 His Ala Glu Gly Arg Glu Gly Asp Phe Pro Ala Ala Asp Leu Asp Ser
     130                 135                 140                
 Leu Trp Glu Asp Phe Ser Gln Ser Leu Ala Arg Gly Asn Ser Glu Leu
 145                 150                 155                 160
 Leu Ala Phe Leu Thr Ser Ser Gly Ala Gly Ser Gln Pro Glu Ala Gln
                 165                 170                 175    
 Arg Glu Leu Asp Val Val Leu Arg Thr Val Ile Pro Lys Thr Ser Pro
             180                 185                 190        
 His Cys Pro Leu Thr Thr Pro Arg Arg Glu Ile Val Val Gln Asp Val
         195                 200                 205            
 Leu Asn Gly Thr Ile Thr Phe Leu Pro Leu Glu Glu Asp Asp Glu Gly
     210                 215                 220                
 Asn Leu Lys Val Lys Met Ser Asn Val Tyr Gln Ile Gln Leu Ser His
 225                 230                 235                 240
 Ser Lys Glu Glu Trp Phe Ile Ser Val Leu Ile Phe Cys Pro Glu Arg
                 245                 250                 255    
 Trp His Ser Asp Gly Ile Val Tyr Pro Lys Pro Thr Trp Leu Gly Glu
             260                 265                 270        
 Glu Leu Leu Ala Lys Leu Ala Lys Trp Ser Val Glu Asn Lys Lys Ser
         275                 280                 285            
 Asp Phe Lys Ser Thr Leu Ser Leu Ile Ser Ile Met Lys Tyr Ser Lys
     290                 295                 300                
 Ala Tyr Gln Asp Leu Lys Glu Lys Tyr Lys Glu Met Val Lys Val Trp
 305                 310                 315                 320
 Pro Glu Val Thr Asp Pro Glu Lys Phe Val Tyr Glu Asp Val Ala Ile
                 325                 330                 335    
 Ala Ala Tyr Leu Leu Ile Leu Trp Glu Glu Glu Arg Ala Glu Arg Gly
             340                 345                 350        
 Leu Thr Ala Arg Gln Ser Phe Val Asp Leu Gly Cys Gly Asn Gly Leu
         355                 360                 365            
 Leu Val His Ile Leu Ser Ser Glu Gly His Pro Gly Arg Gly Ile Asp
     370                 375                 380                
 Val Arg Arg Arg Lys Ile Trp Asp Met Tyr Gly Pro Gln Thr Gln Leu
 385                 390                 395                 400
 Glu Glu Asp Ala Ile Thr Pro Asn Asp Lys Thr Leu Phe Pro Asp Val
                 405                 410                 415    
 Asp Trp Leu Ile Gly Asn His Ser Asp Glu Leu Thr Pro Trp Ile Pro
             420                 425                 430        
 Val Ile Ala Ala Arg Ser Ser Tyr Asn Cys Arg Phe Phe Val Leu Pro
         435                 440                 445            
 Cys Cys Phe Phe Asp Phe Ile Gly Arg Tyr Ser Arg Arg Gln Ser Lys
     450                 455                 460                
 Lys Thr Gln Tyr Arg Glu Tyr Leu Asp Phe Ile Lys Glu Val Gly Phe
 465                 470                 475                 480
 Thr Cys Gly Phe His Val Asp Glu Asp Cys Leu Arg Ile Pro Ser Thr
                 485                 490                 495    
 Lys Arg Val Cys Leu Val Gly Lys Ser Arg Thr Tyr Pro Ser Ser Arg
             500                 505                 510        
 Glu Ala Ser Val Asp Glu Lys Arg Thr Gln Tyr Ile Lys Ser Arg Arg
         515                 520                 525            
 Gly Cys Pro Val Ser Pro Pro Gly Trp Glu Leu Ser Pro Ser Pro Arg
     530                 535                 540                
 Trp Val Ala Ala Gly Ser Ala Gly His Cys Asp Gly Gln Gln Ala Leu
 545                 550                 555                 560
 Asp Ala Arg Val Gly Cys Val Thr Arg Ala Trp Ala Ala Glu His Gly
                 565                 570                 575    
 Ala Gly Pro Gln Ala Glu Gly Pro Trp Leu Pro Gly Phe His Pro Arg
             580                 585                 590        
 Glu Lys Ala Glu Arg Val Arg Asn Cys Ala Ala Leu Pro Arg Asp Phe
         595                 600                 605            
 Ile Asp Gln Val Val Leu Gln Val Ala Asn Leu Leu Leu Gly Gly Lys
     610                 615                 620                
 Gln Leu Asn Thr Arg Ser Ser Arg Asn Gly Ser Leu Lys Thr Trp Asn
 625                 630                 635                 640
 Gly Gly Glu Ser Leu Ser Leu Ala Glu Val Ala Asn Glu Leu Asp Thr
                 645                 650                 655    
 Glu Thr Leu Arg Arg Leu Lys Arg Glu Cys Gly Gly Leu Gln Thr Leu
             660                 665                 670        
 Leu Arg Asn Ser His Gln Val Phe Gln Val Val Asn Gly Arg Val His
         675                 680                 685            
 Ile Arg Asp Trp Arg Glu Glu Thr Leu Trp Lys Thr Lys Gln Pro Glu
     690                 695                 700                
 Ala Lys Gln Arg Leu Leu Ser Glu Ala Cys Lys Thr Arg Leu Cys Trp
 705                 710                 715                 720
 Phe Phe Met His His Pro Asp Gly Cys Ala Leu Ser Thr Asp Cys Cys
                 725                 730                 735    
 Pro Phe Ala His Gly Pro Ala Glu Leu Arg Pro Pro Arg Thr Thr Pro
             740                 745                 750        
 Arg Lys Lys Ile Ser
         755        



      <210> 974
      <211> 125
      <212> PRT
      <213> Homo sapiens


      <400> 974
 Met Glu Pro Asn Pro His Trp His Pro Val Leu Arg Thr Leu Lys Asn
   1               5                  10                  15    
 Arg Ile Glu Glu Asn Thr Gly His Thr Phe Asn Ser Leu Leu Cys Asn
              20                  25                  30        
 Leu Tyr Arg Asn Glu Lys Asp Ser Val Asp Trp His Ser Asp Asp Glu
          35                  40                  45            
 Pro Ser Leu Gly Arg Cys Pro Ile Ile Ala Ser Leu Ser Phe Gly Ala
      50                  55                  60                
 Thr Arg Thr Phe Glu Met Arg Lys Lys Pro Pro Pro Glu Glu Asn Gly
  65                  70                  75                  80
 Asp Tyr Thr Tyr Val Glu Arg Val Lys Ile Pro Leu Asp His Gly Thr
                  85                  90                  95    
 Leu Leu Ile Met Glu Gly Ala Thr Gln Ala Asp Trp Gln Ser Tyr Val
             100                 105                 110        
 Tyr Phe His Leu Ala Ser Ser Ala Gln Arg Ile Pro Leu
         115                 120                 125



      <210> 975
      <211> 408
      <212> PRT
      <213> Homo sapiens


      <400> 975
 Met Glu Lys Ile Glu Glu Gln Phe Ala Asn Leu His Ile Val Lys Cys
   1               5                  10                  15    
 Ser Leu Gly Thr Lys Glu Pro Thr Tyr Leu Leu Gly Ile Asp Thr Ser
              20                  25                  30        
 Lys Thr Val Gln Ala Gly Lys Glu Asn Leu Val Ala Val Leu Cys Ser
          35                  40                  45            
 Asn Gly Ser Ile Arg Ile Tyr Asp Lys Glu Arg Leu Asn Val Leu Arg
      50                  55                  60                
 Glu Phe Ser Gly Tyr Pro Gly Leu Leu Asn Gly Val Arg Phe Ala Asn
  65                  70                  75                  80
 Ser Cys Asp Ser Val Tyr Ser Ala Cys Thr Asp Gly Thr Val Lys Cys
                  85                  90                  95    
 Trp Asp Ala Arg Val Ala Arg Glu Lys Pro Val Gln Leu Phe Lys Gly
             100                 105                 110        
 Tyr Pro Ser Asn Ile Phe Ile Ser Phe Asp Ile Asn Cys Asn Asp His
         115                 120                 125            
 Ile Ile Cys Ala Gly Thr Glu Lys Val Asp Asp Asp Ala Leu Leu Val
     130                 135                 140                
 Phe Trp Asp Ala Arg Met Asn Ser Gln Asn Leu Ser Thr Thr Lys Asp
 145                 150                 155                 160
 Ser Leu Gly Ala Tyr Ser Glu Thr His Ser Asp Asp Val Thr Gln Val
                 165                 170                 175    
 Arg Phe His Pro Ser Asn Pro Asn Met Val Val Ser Gly Ser Ser Asp
             180                 185                 190        
 Gly Leu Val Asn Val Phe Asp Ile Asn Ile Asp Asn Glu Glu Asp Ala
         195                 200                 205            
 Leu Val Thr Thr Cys Asn Ser Ile Ser Ser Val Ser Cys Ile Gly Trp
     210                 215                 220                
 Ser Gly Lys Gly Tyr Lys Gln Ile Tyr Cys Met Thr His Asp Glu Gly
 225                 230                 235                 240
 Phe Tyr Trp Trp Asp Leu Asn His Leu Asp Thr Asp Glu Pro Val Thr
                 245                 250                 255    
 Arg Leu Asn Ile Gln Asp Val Arg Glu Val Val Asn Met Lys Glu Asp
             260                 265                 270        
 Ala Leu Asp Tyr Leu Ile Gly Gly Leu Tyr His Glu Lys Thr Asp Thr
         275                 280                 285            
 Leu His Val Ile Gly Gly Thr Asn Lys Gly Arg Ile His Leu Met Asn
     290                 295                 300                
 Cys Ser Met Ser Gly Leu Thr His Val Thr Ser Leu Gln Gly Gly His
 305                 310                 315                 320
 Ala Ala Thr Val Arg Ser Phe Cys Trp Asn Val Gln Asp Asp Ser Leu
                 325                 330                 335    
 Leu Thr Gly Gly Glu Asp Ala Gln Leu Leu Leu Trp Lys Pro Gly Ala
             340                 345                 350        
 Ile Glu Lys Thr Phe Thr Lys Lys Glu Ser Met Lys Ile Ala Ser Ser
         355                 360                 365            
 Val His Gln Arg Val Arg Val His Ser Asn Asp Ser Tyr Lys Glu Gly
     370                 375                 380                
 Lys Ser Ser Ser Leu Glu Leu Ala Leu Ala Arg Ser Ala Ser Ser Val
 385                 390                 395                 400
 Glu Pro Lys Ala Ser Thr Arg Ile
                 405            



      <210> 976
      <211> 996
      <212> PRT
      <213> Homo sapiens


      <400> 976
 Met Val Ser Thr Leu Ile Lys His Asn Thr Ser Leu Asp Gln Pro Cys
   1               5                  10                  15    
 Val Lys Arg Trp Ser Ala Met His Glu Ala Ala Lys Gln Gly Arg Lys
              20                  25                  30        
 Asp Ile Val Ala Leu Leu Leu Lys His Gly Gly Asn Val His Leu Arg
          35                  40                  45            
 Asp Gly Phe Gly Val Thr Pro Leu Gly Val Ala Ala Glu Tyr Gly His
      50                  55                  60                
 Cys Asp Val Leu Glu His Leu Ile His Lys Gly Gly Asp Val Leu Ala
  65                  70                  75                  80
 Leu Ala Asp Asp Gly Ala Ser Val Leu Phe Glu Ala Ala Gly Gly Gly
                  85                  90                  95    
 Asn Pro Asp Cys Ile Ser Leu Leu Leu Glu Tyr Gly Gly Ser Gly Asn
             100                 105                 110        
 Val Pro Asn Arg Ala Gly His Leu Pro Ile His Arg Ala Ala Tyr Glu
         115                 120                 125            
 Gly His Tyr Leu Ala Leu Lys Tyr Leu Ile Pro Val Thr Ser Lys Asn
     130                 135                 140                
 Ala Ile Arg Lys Ser Gly Leu Thr Pro Ile His Ser Ala Ala Asp Gly
 145                 150                 155                 160
 Gln Asn Ala Gln Cys Leu Glu Leu Leu Ile Glu Asn Gly Phe Asp Val
                 165                 170                 175    
 Asn Thr Leu Leu Ala Asp His Ile Ser Gln Ser Tyr Asp Asp Glu Arg
             180                 185                 190        
 Lys Thr Ala Leu Tyr Phe Gly Val Ser Asn Asn Asp Val His Cys Thr
         195                 200                 205            
 Glu Val Leu Leu Ala Ala Gly Ala Asp Pro Asn Leu Asp Pro Leu Asn
     210                 215                 220                
 Cys Leu Leu Val Ala Val Arg Ala Asn Asn Tyr Glu Ile Val Arg Leu
 225                 230                 235                 240
 Leu Leu Ser His Gly Ala Asn Val Asn Cys Tyr Phe Met His Val Asn
                 245                 250                 255    
 Asp Thr Arg Phe Pro Ser Val Ile Gln Tyr Ala Leu Asn Asp Glu Val
             260                 265                 270        
 Met Leu Arg Leu Leu Leu Asn Asn Gly Tyr Gln Val Glu Met Cys Phe
         275                 280                 285            
 Asp Cys Met His Gly Asp Ile Phe Gly Asn Ser Phe Val Trp Ser Glu
     290                 295                 300                
 Ile Gln Glu Glu Val Leu Pro Gly Trp Thr Ser Cys Val Ile Lys Asp
 305                 310                 315                 320
 Asn Pro Asp Leu Glu Ser Ser Lys Val Thr Val Val Met Thr Leu Arg
                 325                 330                 335    
 Arg Glu Pro Tyr Gln Gly Asp Arg Cys Leu Gly Cys Ser Pro Ser Thr
             340                 345                 350        
 Ser Phe Phe Leu Ile Leu Gln Arg Thr Thr Leu Ser Lys Leu Val Arg
         355                 360                 365            
 Pro Thr Leu Gly Val Ser Gly Gln Arg Lys Gly Leu Ser Ser Glu Asp
     370                 375                 380                
 Leu Phe Glu Thr Ala Pro Ser Gly Ser Asp Lys Ala Gly Thr Met Ser
 385                 390                 395                 400
 Thr Phe Gly Tyr Arg Arg Gly Leu Ser Lys Tyr Glu Ser Ile Asp Glu
                 405                 410                 415    
 Asp Glu Leu Leu Ala Ser Leu Ser Ala Glu Glu Leu Lys Glu Leu Glu
             420                 425                 430        
 Arg Glu Leu Glu Asp Ile Glu Pro Asp Arg Asn Leu Pro Val Gly Leu
         435                 440                 445            
 Arg Gln Lys Ser Leu Thr Glu Lys Thr Pro Thr Gly Thr Phe Ser Arg
     450                 455                 460                
 Glu Ala Leu Met Ala Tyr Trp Glu Lys Glu Ser Gln Lys Leu Leu Glu
 465                 470                 475                 480
 Lys Glu Arg Leu Gly Glu Cys Gly Lys Val Ala Glu Asp Lys Glu Glu
                 485                 490                 495    
 Ser Glu Glu Glu Leu Ile Phe Thr Glu Ser Asn Ser Glu Val Ser Glu
             500                 505                 510        
 Glu Val Tyr Thr Glu Glu Glu Glu Glu Glu Ser Gln Glu Glu Glu Glu
         515                 520                 525            
 Glu Glu Asp Ser Asp Glu Glu Glu Arg Thr Ile Glu Thr Ala Lys Gly
     530                 535                 540                
 Ile Asn Gly Thr Val Asn Tyr Asp Ser Val Asn Ser Asp Asn Ser Lys
 545                 550                 555                 560
 Pro Lys Ile Phe Lys Ser Gln Ile Glu Asn Ile Asn Leu Thr Asn Gly
                 565                 570                 575    
 Ser Asn Gly Arg Asn Thr Glu Ser Pro Ala Ala Ile His Pro Cys Gly
             580                 585                 590        
 Asn Pro Thr Val Ile Glu Asp Ala Leu Asp Lys Ile Lys Ser Asn Asp
         595                 600                 605            
 Pro Asp Thr Thr Glu Val Asn Leu Asn Asn Ile Glu Asn Ile Thr Thr
     610                 615                 620                
 Gln Thr Leu Thr Arg Phe Ala Glu Ala Leu Lys Asp Asn Thr Val Val
 625                 630                 635                 640
 Lys Thr Phe Ser Leu Ala Asn Thr His Ala Asp Asp Ser Ala Ala Met
                 645                 650                 655    
 Ala Ile Ala Glu Met Leu Lys Val Asn Glu His Ile Thr Asn Val Asn
             660                 665                 670        
 Val Glu Ser Asn Phe Ile Thr Gly Lys Gly Ile Leu Ala Ile Met Arg
         675                 680                 685            
 Ala Leu Gln His Asn Thr Val Leu Thr Glu Leu Arg Phe His Asn Gln
     690                 695                 700                
 Arg His Ile Met Gly Ser Gln Val Glu Met Glu Ile Val Lys Leu Leu
 705                 710                 715                 720
 Lys Glu Asn Thr Thr Leu Leu Arg Leu Gly Tyr His Phe Glu Leu Pro
                 725                 730                 735    
 Gly Pro Arg Met Ser Met Thr Ser Ile Leu Thr Arg Asn Met Asp Lys
             740                 745                 750        
 Gln Arg Gln Lys Arg Leu Gln Glu Gln Lys Gln Gln Glu Gly Tyr Asp
         755                 760                 765            
 Gly Gly Pro Asn Leu Arg Thr Lys Val Trp Gln Arg Gly Thr Pro Ser
     770                 775                 780                
 Ser Ser Pro Tyr Val Ser Pro Arg His Ser Pro Trp Ser Ser Pro Lys
 785                 790                 795                 800
 Leu Pro Lys Lys Val Gln Thr Val Arg Ser Arg Pro Leu Ser Pro Val
                 805                 810                 815    
 Ala Thr Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ser
             820                 825                 830        
 Ser Gln Arg Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro
         835                 840                 845            
 Glu Lys Lys Leu Ile Thr Arg Asn Ile Ala Glu Val Ile Lys Gln Gln
     850                 855                 860                
 Glu Ser Ala Gln Arg Ala Leu Gln Asn Gly Gln Lys Lys Lys Lys Gly
 865                 870                 875                 880
 Lys Lys Val Lys Lys Gln Pro Asn Ser Ile Leu Lys Glu Ile Lys Asn
                 885                 890                 895    
 Ser Leu Arg Ser Val Gln Glu Lys Lys Met Glu Asp Ser Ser Arg Pro
             900                 905                 910        
 Ser Thr Pro Gln Arg Ser Ala His Glu Asn Leu Met Glu Ala Ile Arg
         915                 920                 925            
 Gly Ser Ser Ile Lys Gln Leu Lys Arg Met Thr Glu Val Pro Cys Asp
     930                 935                 940                
 Asp Gln Met Leu Gly Gln Cys Arg Val Thr Ala Ala Asn Glu Pro Lys
 945                 950                 955                 960
 Tyr Asn His Met His Gln Ser Gln Arg Leu Ala Pro Gln Asn Lys Pro
                 965                 970                 975    
 Ala Phe Leu Val Arg Asp Gly His Arg Met Leu Ala Ala Ser Ile Asn
             980                 985                 990        
 Thr Gln Met Ile
         995    



      <210> 977
      <211> 104
      <212> PRT
      <213> Homo sapiens


      <400> 977
 Met Gly Pro Ala Asp Arg Asp Ala Val Gly Arg Ala Pro Arg Arg Pro
   1               5                  10                  15    
 Phe Ser Gln Ala Ser Pro Trp Pro Arg Val Leu Leu Ala Gln Gly His
              20                  25                  30        
 Glu Ser Lys Met Lys Arg Leu Val Phe Leu Leu Asp Thr Ser Gly Gln
          35                  40                  45            
 Ala Glu Asn Lys Arg Leu Lys Arg Gly Ser Pro Arg Ile Glu Glu Met
      50                  55                  60                
 Arg Ala Leu Arg Ser Ala Arg Leu Pro Arg Gln Leu Thr His Lys Ser
  65                  70                  75                  80
 Ser Gly Pro Asn Cys Thr Lys Tyr Phe Val Arg Ser Pro Asn Thr Asn
                  85                  90                  95    
 Phe Phe Thr Thr Ala His Val Arg
             100                



      <210> 978
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 978
 Met Ala Pro Lys Trp Leu Gln Ala Met Val Gln Arg Asp His Trp Arg
   1               5                  10                  15    
 Glu Pro Trp Arg Leu Leu Ser Leu His Val Pro Ala His Leu Gly Ala
              20                  25                  30        
 Asp Leu Pro Thr Leu Val Thr Arg Val Tyr Ile Ser Leu Tyr Ala Ser
          35                  40                  45            
 His Gln Leu Thr Leu Leu Arg Gly Pro Leu Leu Asn Ser Trp Phe Leu
      50                  55                  60                
 Tyr Pro Ser Gly Asn Val Tyr Lys Phe Gln Thr Gly Ser Arg Phe His
  65                  70                  75                  80
 Ala Ile Leu Trp His Lys His Leu Asp Asp Ala Cys Lys Ser Asn Arg
                  85                  90                  95    
 Pro Gln Glu Ala Gly Ala Ala Pro Gly Pro Thr Gly Thr Asp Ser His
             100                 105                 110        
 Glu Val Asp His Leu Glu Gly Gly Ala Gly Lys Glu Ala Gly Pro Cys
         115                 120                 125            
 Ala
    



      <210> 979
      <211> 188
      <212> PRT
      <213> Homo sapiens


      <400> 979
 Met Pro Ser Thr Ser Glu Gly Ser Ile Tyr Pro Glu Met Ala His Phe
   1               5                  10                  15    
 Leu Arg Asn Lys Leu Ala Gly Ser Ser Val Arg Lys Pro Asp Ser Gly
              20                  25                  30        
 Phe Leu Trp Glu Gly Ala Leu Arg Ala Trp Ser Ser Met Val Ala Pro
          35                  40                  45            
 Ser Gly Ser Val Asn Cys Glu Glu Phe Ala Glu Phe Gln Glu Leu Leu
      50                  55                  60                
 Lys Val Met Arg Pro Ile Asp Asp Arg Ile Val His Glu Leu Asn Thr
  65                  70                  75                  80
 Thr Val Pro Thr Pro Ser Phe Ala Gly Lys Ile Asp Ala Ser Gln Thr
                  85                  90                  95    
 Cys Lys Gln Leu Tyr Glu Ser Leu Met Ala Ala His Ala Ser Arg Asp
             100                 105                 110        
 Arg Val Ile Lys Asn Cys Ile Ala Gln Thr Ser Ala Val Val Lys Asn
         115                 120                 125            
 Leu Arg Glu Glu Arg Glu Lys Asn Leu Asp Asp Leu Thr Leu Leu Lys
     130                 135                 140                
 Gln Leu Arg Lys Glu Gln Thr Lys Leu Lys Trp Met Gln Ser Glu Leu
 145                 150                 155                 160
 Asn Val Glu Glu Val Val Asn Asp Arg Ser Trp Lys Val Phe Asn Glu
                 165                 170                 175    
 Arg Cys Arg Ile His Phe Lys Pro Pro Lys Asn Glu
             180                 185            



      <210> 980
      <211> 373
      <212> PRT
      <213> Homo sapiens


      <400> 980
 Met Ala Glu Leu Asp Gln Leu Pro Asp Glu Ser Ser Ser Ala Lys Ala
   1               5                  10                  15    
 Leu Val Ser Leu Lys Glu Gly Ser Leu Ser Asn Thr Trp Asn Glu Lys
              20                  25                  30        
 Tyr Ser Ser Leu Gln Lys Thr Pro Val Trp Lys Gly Arg Asn Thr Ser
          35                  40                  45            
 Ser Ala Val Glu Met Pro Phe Arg Asn Ser Lys Arg Ser Arg Leu Phe
      50                  55                  60                
 Ser Asp Glu Asp Asp Arg Gln Ile Asn Thr Arg Ser Pro Lys Arg Asn
  65                  70                  75                  80
 Gln Arg Val Ala Met Val Pro Gln Lys Phe Thr Ala Thr Met Ser Thr
                  85                  90                  95    
 Pro Asp Lys Lys Ala Ser Gln Lys Ile Gly Phe Arg Leu Arg Asn Leu
             100                 105                 110        
 Leu Lys Leu Pro Lys Ala His Lys Trp Cys Ile Tyr Glu Trp Phe Tyr
         115                 120                 125            
 Ser Asn Ile Asp Lys Pro Leu Phe Glu Gly Asp Asn Asp Phe Cys Val
     130                 135                 140                
 Cys Leu Lys Glu Ser Phe Pro Asn Leu Lys Thr Arg Lys Leu Thr Arg
 145                 150                 155                 160
 Val Glu Trp Gly Lys Ile Arg Arg Leu Met Gly Lys Pro Arg Arg Cys
                 165                 170                 175    
 Ser Ser Ala Phe Phe Glu Glu Glu Arg Ser Ala Leu Lys Gln Lys Arg
             180                 185                 190        
 Gln Lys Ile Arg Leu Leu Gln Gln Arg Lys Val Ala Asp Val Ser Gln
         195                 200                 205            
 Phe Lys Asp Leu Pro Asp Glu Ile Pro Leu Pro Leu Val Ile Gly Thr
     210                 215                 220                
 Lys Val Thr Ala Arg Leu Arg Gly Val His Asp Gly Leu Phe Thr Gly
 225                 230                 235                 240
 Gln Ile Asp Ala Val Asp Thr Leu Asn Ala Thr Tyr Arg Val Thr Phe
                 245                 250                 255    
 Asp Arg Thr Gly Leu Gly Thr His Thr Ile Pro Asp Tyr Glu Val Leu
             260                 265                 270        
 Ser Asn Glu Pro His Glu Thr Met Pro Ile Ala Ala Phe Gly Gln Lys
         275                 280                 285            
 Gln Arg Pro Ser Arg Phe Phe Met Thr Pro Pro Arg Leu His Tyr Thr
     290                 295                 300                
 Pro Pro Leu Gln Ser Pro Ile Ile Asp Asn Asp Pro Leu Leu Gly Gln
 305                 310                 315                 320
 Ser Pro Trp Arg Ser Lys Ile Ser Gly Ser Asp Thr Glu Thr Leu Gly
                 325                 330                 335    
 Gly Phe Pro Val Glu Phe Leu Ile Gln Val Thr Arg Leu Ser Lys Ile
             340                 345                 350        
 Leu Met Ile Lys Lys Glu His Ile Lys Lys Leu Arg Glu Met Asn Thr
         355                 360                 365            
 Glu Ala Glu Lys Leu
     370            



      <210> 981
      <211> 524
      <212> PRT
      <213> Homo sapiens


      <400> 981
 Met Leu Gln Val Ser Ala Lys Arg Pro Pro Lys Thr Pro Pro Cys Pro
   1               5                  10                  15    
 Pro Ser Cys Ser Cys Thr Arg Asp Thr Cys Phe Cys Val Asp Ser Lys
              20                  25                  30        
 Ala Val Pro Arg Asn Leu Pro Ser Glu Val Ile Ser Leu Thr Leu Val
          35                  40                  45            
 Asn Ala Ala Phe Ser Glu Ile Gln Asp Gly Ala Phe Ser His Leu Pro
      50                  55                  60                
 Leu Leu Gln Phe Leu Leu Leu Asn Ser Asn Lys Phe Thr Leu Ile Gly
  65                  70                  75                  80
 Asp Asn Ala Phe Thr Gly Leu Ser His Leu Gln Tyr Leu Phe Ile Glu
                  85                  90                  95    
 Asn Asn Asp Ile Trp Ala Leu Ser Lys Phe Thr Phe Arg Gly Leu Lys
             100                 105                 110        
 Ser Leu Thr His Leu Ser Leu Ala Asn Asn Asn Leu Gln Thr Leu Pro
         115                 120                 125            
 Arg Asp Ile Phe Arg Pro Leu Asp Ile Leu Asn Asp Leu Asp Leu Arg
     130                 135                 140                
 Gly Asn Ser Leu Asn Cys Asp Cys Lys Val Lys Trp Leu Val Glu Trp
 145                 150                 155                 160
 Leu Ala His Thr Asn Thr Thr Val Ala Pro Ile Tyr Cys Ala Ser Pro
                 165                 170                 175    
 Pro Arg Phe Gln Glu His Lys Val Gln Asp Leu Pro Leu Arg Glu Phe
             180                 185                 190        
 Asp Cys Ile Thr Thr Asp Phe Val Leu Tyr Gln Thr Leu Ala Phe Pro
         195                 200                 205            
 Ala Val Ser Ala Glu Pro Phe Leu Tyr Ser Ser Asp Leu Tyr Leu Ala
     210                 215                 220                
 Leu Ala Gln Pro Gly Val Ser Ala Cys Thr Ile Leu Lys Trp Asp Tyr
 225                 230                 235                 240
 Val Glu Arg Gln Leu Arg Asp Tyr Asp Arg Ile Pro Ala Pro Ser Ala
                 245                 250                 255    
 Val His Cys Lys Pro Met Val Val Asp Ser Gln Leu Tyr Val Val Val
             260                 265                 270        
 Ala Gln Leu Phe Gly Gly Ser Tyr Ile Tyr His Trp Asp Pro Asn Thr
         275                 280                 285            
 Thr Arg Phe Thr Arg Leu Gln Asp Ile Asp Pro Gln Arg Val Arg Lys
     290                 295                 300                
 Pro Asn Asp Leu Glu Ala Phe Arg Ile Asp Gly Asp Trp Tyr Phe Ala
 305                 310                 315                 320
 Val Ala Asp Ser Ser Lys Ala Gly Ala Thr Ser Leu Tyr Arg Trp His
                 325                 330                 335    
 Gln Asn Gly Phe Tyr Ser His Gln Ala Leu His Pro Trp His Arg Asp
             340                 345                 350        
 Thr Asp Leu Glu Phe Val Asp Gly Glu Gly Lys Pro Arg Leu Ile Val
         355                 360                 365            
 Ser Ser Ser Ser Gln Ala Pro Val Ile Tyr Gln Trp Ser Arg Thr Gln
     370                 375                 380                
 Lys Gln Phe Val Ala Gln Gly Glu Val Thr Gln Val Pro Asp Ala Gln
 385                 390                 395                 400
 Ala Val Lys His Phe Arg Ala Gly Arg Asp Ser Tyr Leu Cys Leu Ser
                 405                 410                 415    
 Arg Tyr Ile Gly Asp Ser Lys Ile Leu Arg Trp Glu Gly Thr Arg Phe
             420                 425                 430        
 Ser Glu Val Gln Ala Leu Pro Ser Arg Gly Ser Leu Ala Leu Gln Pro
         435                 440                 445            
 Phe Leu Val Gly Gly Arg Arg Tyr Leu Ala Leu Gly Ser Asp Phe Ser
     450                 455                 460                
 Phe Thr Gln Ile Tyr Gln Trp Asp Glu Gly Arg Gln Lys Phe Val Arg
 465                 470                 475                 480
 Phe Gln Glu Leu Ala Val Gln Ala Pro Arg Ala Phe Cys Tyr Met Pro
                 485                 490                 495    
 Ala Gly Asp Ala Gln Leu Leu Leu Ala Pro Ser Phe Lys Gly Gln Thr
             500                 505                 510        
 Leu Val Tyr Arg His Ile Val Val Asp Leu Ser Ala
         515                 520                



      <210> 982
      <211> 782
      <212> PRT
      <213> Homo sapiens


      <400> 982
 Met Thr Cys Leu Arg Thr Gly Thr Glu Gly Ala Gln Gly Gly Val Gly
   1               5                  10                  15    
 Arg Gly Thr Gln Ala Gly Gly Pro Gly Gly Ala Pro Ser Leu Thr Pro
              20                  25                  30        
 Glu Ala Ala Gly Ala Ala Arg Arg Glu Asp Thr Ser Gly Pro Ser Val
          35                  40                  45            
 Pro Leu Ser Phe Pro Ala Ala Arg Cys Pro Arg Lys Val Pro Gly Leu
      50                  55                  60                
 Pro Pro Leu Gly Leu Leu Glu Ser Phe Gly Gly Cys Arg Ala Leu Ala
  65                  70                  75                  80
 Ala Arg Arg Gln Ala Ser Arg Gly Ala Gly Thr Ala Ala Gly Ser Gly
                  85                  90                  95    
 Arg Ala Arg Leu Glu Cys Ser Val Gln Asp Ala Arg Thr Gly Pro Ala
             100                 105                 110        
 Arg Asn Pro Arg Pro Arg Ala Ser Pro Pro Ala Leu Thr Arg Pro Val
         115                 120                 125            
 Arg Lys Ala Asp Arg Ala Gly Asp Ala Asn Leu Arg Pro Ala Pro Ser
     130                 135                 140                
 Asp Ser Lys Phe Ser His Trp Ser Arg Asp Pro Ala Arg His Gly Asn
 145                 150                 155                 160
 Arg Arg Arg Leu Gly Gly Cys Ala Glu Met Thr Ala Cys His Trp Ala
                 165                 170                 175    
 Ser Gly Met Ser Val Pro Ala Asp Asp Arg Pro Pro Arg Gly Gly Ala
             180                 185                 190        
 Ala Ala Pro His Leu Pro Glu Pro Leu Arg Arg Arg Trp Gln Gly Thr
         195                 200                 205            
 Arg Asp Arg Ser Leu Pro Ala Asp Leu Arg Glu His Pro Pro Thr Ile
     210                 215                 220                
 Gln Pro Arg Ala Gly Thr Gly Arg Ala Gly Ala Pro Ser Pro Asp Ser
 225                 230                 235                 240
 Gly Arg Val Ala Ser Ala Thr Thr Pro Ser Ser Gln Val Ser Phe Phe
                 245                 250                 255    
 Ser Ala Cys Tyr Ser Leu Arg Ala Ala Arg Arg Ser Leu Leu Ser Thr
             260                 265                 270        
 Ser Asn Cys Ile Leu His Ala Ser Arg Glu Arg Glu Phe Cys Cys Tyr
         275                 280                 285            
 Pro His Phe Thr Val Gly Lys Gln Pro Gln Arg Gly Ser His Leu Leu
     290                 295                 300                
 Glu His Ser Arg Leu Thr Leu Gly Pro Gly Gly Ser Leu Ile Leu Thr
 305                 310                 315                 320
 Pro Leu Gly Pro Arg Ser Gly Glu Thr Met Glu Gly Ala Ala Glu Ser
                 325                 330                 335    
 Pro Lys Ala Ala Gly Ser Gly Ser Ala Gln Thr Pro Ala Gln Pro Glu
             340                 345                 350        
 Ala Leu Ala Gln Pro Arg Gly Arg Gly Ala Arg Arg Trp Gln Pro Pro
         355                 360                 365            
 Ser Asp Ser Ala Pro Ser Gln Arg Asp Ala Gly Met Arg Arg Ala Ala
     370                 375                 380                
 Pro Pro Leu Ala Ala Arg Pro Asn Gly Glu Arg Ala Gly Phe Gly Leu
 385                 390                 395                 400
 Gly Gly Thr Gly Leu Ala Ala Val Ala Arg Gly Arg Gly Thr Arg Lys
                 405                 410                 415    
 Ser Ala Ala Val Ala Glu Ala Thr Ser Arg Pro Val Ser Ala Glu Pro
             420                 425                 430        
 Pro Cys Thr Thr Met Cys Ile Ile Phe Phe Lys Phe Asp Pro Arg Pro
         435                 440                 445            
 Val Ser Lys Asn Ala Tyr Arg Val Leu Gly Ala Gln Pro Val Leu Met
     450                 455                 460                
 Pro Pro Lys Leu Leu Cys Ala Gly Arg Leu Ile Leu Ala Ala Asn Arg
 465                 470                 475                 480
 Asp Glu Phe Tyr Ser Arg Pro Ser Lys Leu Ala Asp Phe Trp Gly Asn
                 485                 490                 495    
 Asn Asn Glu Ile Leu Ser Gly Leu Asp Met Glu Glu Gly Lys Glu Gly
             500                 505                 510        
 Gly Thr Trp Leu Gly Ile Ser Thr Arg Gly Lys Leu Ala Ala Leu Thr
         515                 520                 525            
 Asn Tyr Leu Gln Pro Gln Leu Asp Trp Gln Ala Arg Gly Arg Gly Glu
     530                 535                 540                
 Leu Val Thr His Phe Leu Thr Thr Asp Val Asp Ser Leu Ser Tyr Leu
 545                 550                 555                 560
 Lys Lys Val Ser Met Glu Gly His Leu Tyr Asn Gly Phe Asn Leu Ile
                 565                 570                 575    
 Ala Ala Asp Leu Ser Thr Ala Lys Gly Asp Val Ile Cys Tyr Tyr Gly
             580                 585                 590        
 Asn Arg Gly Glu Pro Asp Pro Ile Val Leu Thr Pro Gly Thr Tyr Gly
         595                 600                 605            
 Leu Ser Asn Ala Leu Leu Glu Thr Pro Trp Arg Lys Leu Cys Phe Gly
     610                 615                 620                
 Lys Gln Leu Phe Leu Glu Ala Val Glu Arg Ser Gln Ala Leu Pro Lys
 625                 630                 635                 640
 Asp Val Leu Ile Ala Ser Leu Leu Asp Val Leu Asn Asn Glu Glu Ala
                 645                 650                 655    
 Gln Leu Pro Asp Pro Ala Ile Glu Asp Gln Gly Gly Glu Tyr Val Gln
             660                 665                 670        
 Pro Met Leu Ser Lys Tyr Ala Ala Val Cys Val Arg Cys Pro Gly Tyr
         675                 680                 685            
 Gly Thr Arg Tyr Cys Ser Thr Val Gly Ala Pro Pro Pro Ile Pro Cys
     690                 695                 700                
 Pro Thr Ser His Ala Arg Gly Pro Ala Lys Lys Pro Ser Ala His Ser
 705                 710                 715                 720
 Gln Ser Gln Ala Ser Ser Ser Pro Glu Trp Ile Pro Glu Leu Leu Pro
                 725                 730                 735    
 Cys Pro Asp Ala Ala Ala Gly Thr Asn Thr Ile Ile Leu Val Asp Ala
             740                 745                 750        
 Asp Gly His Val Thr Phe Thr Glu Arg Ser Met Met Asp Lys Asp Leu
         755                 760                 765            
 Ser His Trp Glu Thr Arg Thr Tyr Glu Phe Thr Leu Gln Ser
     770                 775                 780        



      <210> 983
      <211> 430
      <212> PRT
      <213> Homo sapiens


      <400> 983
 Met Gly Ser Leu Thr Leu Pro Asp His Glu Val Ser Val Gln Pro Pro
   1               5                  10                  15    
 Gly Glu Asp Gln Ala Tyr Tyr Gln Leu Ala Asn Ile Thr Val Lys Pro
              20                  25                  30        
 Ala Asp Val Glu Val Thr Ile Thr Ser Glu Pro Lys Asn Glu Thr Glu
          35                  40                  45            
 Ser Ser Gln Ala Gln Gln Glu Ala Pro Ile Gln Pro Pro Glu Glu Val
      50                  55                  60                
 Ala Pro Ser Ala Thr Gln Gln Glu Ala Pro Thr Glu Pro Pro Gly Pro
  65                  70                  75                  80
 Pro Met Glu Pro Glu Leu Ser Pro Ser Glu Gln Glu Gln Pro Ala Gln
                  85                  90                  95    
 Pro Ser Glu Ser Ser Gly Glu Val Glu Ser Ser Pro Ala Gln His Glu
             100                 105                 110        
 Thr Pro Ala Gln Pro Pro Glu Glu Met Glu Pro Ser Ala Phe Gln Glu
         115                 120                 125            
 Glu Ala Pro Thr Glu Pro Pro Arg Pro Pro Ile Glu Pro Glu Leu Ser
     130                 135                 140                
 Pro Lys Ser Ser Glu Glu Ala Gly His Leu Gln Ile Gln Gln Glu Thr
 145                 150                 155                 160
 Ser Val Gln Ser Pro Glu Pro Ile Asn Lys Glu Asn Thr Thr Pro Thr
                 165                 170                 175    
 Gln Gln Glu Ala Ala Ala Glu His Pro Gln Thr Ala Glu Glu Asp Lys
             180                 185                 190        
 Gly Gln Ala Gln Leu Ser His Leu Thr Glu Ala Thr Val Gln Pro Leu
         195                 200                 205            
 Asp Leu Glu Leu Ser Ile Thr Thr Glu Pro Thr Thr Glu Val Lys Pro
     210                 215                 220                
 Ser Pro Thr Thr Glu Glu Thr Ser Ala Gln Pro Leu Asp Pro Gly Leu
 225                 230                 235                 240
 Ala Ile Thr Pro Glu Pro Thr Thr Glu Ile Gly His Ser Thr Ala Leu
                 245                 250                 255    
 Glu Lys Thr Arg Ala Pro His Pro Asp Gln Val Gln Thr Leu His Arg
             260                 265                 270        
 Ser Leu Thr Glu Val Thr Gly Pro Pro Thr Lys Leu Glu Ser Ser Gln
         275                 280                 285            
 Asp Ser Leu Val Gln Ser Glu Thr Ala Pro Glu Glu Gln Lys Ala Ser
     290                 295                 300                
 Thr Gly Thr Asn Ile Cys Glu Leu Cys Thr Cys Gly Asp Glu Thr Leu
 305                 310                 315                 320
 Ser Cys Val Gly Leu Ser Pro Lys Gln Arg Leu Arg Gln Val Pro Val
                 325                 330                 335    
 Pro Glu Pro Tyr Thr Tyr Asn Gly Ile Phe Thr Thr Leu Asn Phe Gln
             340                 345                 350        
 Gly Asn Tyr Ile Ser Tyr Ile Asp Gly Asn Val Trp Lys Ala Tyr Ser
         355                 360                 365            
 Trp Thr Glu Lys Leu Ile Leu Ser Glu Asn Tyr Leu Thr Glu Leu Pro
     370                 375                 380                
 Lys Asp Ser Phe Glu Gly Leu Leu Ser Leu Gln Tyr Leu Gln Ile Leu
 385                 390                 395                 400
 Ser Asn Val Lys Gly Leu Arg Lys Val Gly Val Lys Ala Leu Lys Trp
                 405                 410                 415    
 Met Pro Lys Cys Cys Arg Gly His Glu Val Ile Lys Leu His
             420                 425                 430



      <210> 984
      <211> 310
      <212> PRT
      <213> Homo sapiens


      <400> 984
 Met Val Pro Gly Ala Gly Met Gly Ser Trp Asp Gly Ala Met Ile Trp
   1               5                  10                  15    
 Ser Glu Thr Lys Phe Ala His Gln Ser Glu Ala Ser Phe Pro Val Glu
              20                  25                  30        
 Asp Glu Ser Arg Lys Gln Thr Arg Thr Gly Glu Lys Thr Arg Pro Trp
          35                  40                  45            
 Ser Cys Arg Cys Lys His Glu Ala Asn Met Asp Pro Arg Asp Leu Glu
      50                  55                  60                
 Lys Leu Ile Cys Met Ile Glu Met Thr Glu Asp Pro Ser Val His Glu
  65                  70                  75                  80
 Ile Ala Asn Asn Ala Leu Tyr Asn Ser Ala Asp Tyr Ser Tyr Ser His
                  85                  90                  95    
 Glu Val Val Arg Asn Val Gly Gly Ile Ser Val Ile Glu Ser Leu Leu
             100                 105                 110        
 Asn Asn Pro Tyr Pro Ser Val Arg Gln Lys Ala Leu Asn Ala Leu Asn
         115                 120                 125            
 Asn Ile Ser Val Ala Ala Glu Asn His Arg Lys Val Lys Thr Tyr Leu
     130                 135                 140                
 Asn Gln Val Cys Glu Asp Thr Val Thr Tyr Pro Leu Asn Ser Asn Val
 145                 150                 155                 160
 Gln Leu Ala Gly Leu Arg Leu Ile Arg His Leu Thr Ile Thr Ser Glu
                 165                 170                 175    
 Tyr Gln His Met Val Thr Asn Tyr Ile Ser Glu Phe Leu Arg Leu Leu
             180                 185                 190        
 Thr Val Gly Ser Gly Glu Thr Lys Asp His Val Leu Gly Met Leu Leu
         195                 200                 205            
 Asn Phe Ser Lys Asn Pro Ser Met Thr Lys Asp Leu Leu Ile Ala Asn
     210                 215                 220                
 Ala Pro Thr Ser Leu Ile Asn Ile Phe Ser Lys Lys Glu Thr Lys Glu
 225                 230                 235                 240
 Asn Ile Leu Asn Ala Leu Ser Leu Phe Glu Asn Ile Asn Tyr His Phe
                 245                 250                 255    
 Lys Arg Arg Ala Lys Ala Phe Thr Gln Asp Lys Phe Ser Lys Asn Ser
             260                 265                 270        
 Leu Tyr Phe Leu Phe Gln Arg Pro Lys Ala Cys Ala Lys Lys Leu Arg
         275                 280                 285            
 Ala Leu Ala Ala Glu Cys Asn Asp Pro Glu Val Lys Glu Arg Val Glu
     290                 295                 300                
 Leu Leu Ile Ser Lys Leu
 305                 310



      <210> 985
      <211> 1685
      <212> PRT
      <213> Homo sapiens


      <400> 985
 Met Leu Pro Pro Lys His Leu Ser Ala Thr Lys Pro Lys Lys Ser Trp
   1               5                  10                  15    
 Ala Pro Asn Leu Tyr Glu Leu Asp Ser Asp Leu Thr Lys Glu Pro Asp
              20                  25                  30        
 Val Ile Ile Gly Glu Gly Pro Thr Asp Ser Glu Phe Phe His Gln Arg
          35                  40                  45            
 Phe Arg Asn Leu Ile Tyr Val Glu Phe Val Gly Pro Arg Lys Thr Leu
      50                  55                  60                
 Ile Lys Leu Arg Asn Leu Cys Leu Asp Trp Leu Gln Pro Glu Thr Arg
  65                  70                  75                  80
 Thr Lys Glu Glu Ile Ile Glu Leu Leu Val Leu Glu Gln Tyr Leu Thr
                  85                  90                  95    
 Ile Ile Pro Glu Lys Leu Lys Pro Trp Val Arg Ala Lys Lys Pro Glu
             100                 105                 110        
 Asn Cys Glu Lys Leu Val Thr Leu Leu Glu Asn Tyr Lys Glu Met Tyr
         115                 120                 125            
 Gln Pro Glu Gly Glu Ser Leu His Gly Val Leu Val Val Ser Ala Gly
     130                 135                 140                
 Leu Arg Cys Pro Leu Gly Leu Ser Ala Ser Thr Leu Leu Thr Trp Ser
 145                 150                 155                 160
 Gly Leu Asp Asn Ser Leu Ser Trp Ala Ala Val Gly Met Ser Cys Val
                 165                 170                 175    
 Leu Trp Asp Ile Glu Leu His His Asp Phe Leu Gly Val Ala Thr Lys
             180                 185                 190        
 Ser Val Ser Thr His Ala Gln Gly Asp Ala Ala Gln Gly Leu Gly Gly
         195                 200                 205            
 Thr Ile Val Arg Met Trp Ala Arg Asp Ser Asn Leu Ala Thr Gly Val
     210                 215                 220                
 Leu Leu Asp Asp Asn Asn Ser Asp Val Thr Ser Asp Asp Asp Met Thr
 225                 230                 235                 240
 Arg Asn Arg Arg Glu Ser Ser Pro Pro His Ser Val His Ser Phe Ser
                 245                 250                 255    
 Gly Asp Arg Asp Trp Asp Arg Arg Gly Arg Ser Arg Asp Met Glu Pro
             260                 265                 270        
 Arg Asp Arg Trp Ser His Thr Arg Asn Pro Arg Ser Arg Met Pro Pro
         275                 280                 285            
 Arg Asp Leu Ser Leu Pro Val Val Ala Lys Thr Ser Phe Glu Met Asp
     290                 295                 300                
 Arg Glu Asp Asp Arg Asp Ser Arg Ala Tyr Glu Ser Arg Ser Gln Asp
 305                 310                 315                 320
 Ala Glu Ser Tyr Gln Asn Val Val Asp Leu Ala Glu Asp Arg Lys Pro
                 325                 330                 335    
 His Asn Thr Ile Gln Asp Asn Met Glu Asn Tyr Arg Lys Leu Leu Ser
             340                 345                 350        
 Leu Gly Val Gln Leu Ala Glu Asp Asp Gly His Ser His Met Thr Gln
         355                 360                 365            
 Gly His Ser Ser Arg Ser Lys Arg Ser Ala Tyr Pro Ser Thr Ser Arg
     370                 375                 380                
 Gly Leu Lys Thr Met Pro Glu Ala Lys Lys Ser Thr His Arg Arg Gly
 385                 390                 395                 400
 Ile Cys Glu Asp Glu Ser Ser His Gly Val Ile Met Glu Lys Phe Ile
                 405                 410                 415    
 Lys Asp Val Ser Arg Ser Ser Lys Ser Gly Arg Ala Arg Glu Ser Ser
             420                 425                 430        
 Asp Arg Ser Gln Arg Phe Pro Arg Met Ser Asp Asp Asn Trp Lys Asp
         435                 440                 445            
 Ile Ser Leu Asn Lys Arg Glu Ser Val Ile Gln Gln Arg Val Tyr Glu
     450                 455                 460                
 Gly Asn Ala Phe Arg Gly Gly Phe Arg Phe Asn Ser Thr Leu Val Ser
 465                 470                 475                 480
 Arg Lys Arg Val Leu Glu Arg Lys Arg Arg Tyr His Phe Asp Thr Asp
                 485                 490                 495    
 Gly Lys Gly Ser Ile His Asp Gln Lys Gly Cys Pro Arg Lys Lys Pro
             500                 505                 510        
 Phe Glu Cys Gly Ser Glu Met Arg Lys Ala Met Ser Val Ser Ser Leu
         515                 520                 525            
 Ser Ser Leu Ser Ser Pro Ser Phe Thr Glu Ser Gln Pro Ile Asp Phe
     530                 535                 540                
 Gly Ala Met Pro Tyr Val Cys Asp Glu Cys Gly Arg Ser Phe Ser Val
 545                 550                 555                 560
 Ile Ser Glu Phe Val Glu His Gln Ile Met His Thr Arg Glu Asn Leu
                 565                 570                 575    
 Tyr Glu Tyr Gly Glu Ser Phe Ile His Ser Val Ala Val Ser Glu Val
             580                 585                 590        
 Gln Lys Ser Gln Val Gly Gly Lys Arg Phe Glu Cys Lys Asp Cys Gly
         595                 600                 605            
 Glu Thr Phe Asn Lys Ser Ala Ala Leu Ala Glu His Arg Lys Ile His
     610                 615                 620                
 Ala Arg Gly Tyr Leu Val Glu Cys Lys Asn Gln Glu Cys Glu Glu Ala
 625                 630                 635                 640
 Phe Met Pro Ser Pro Thr Phe Ser Glu Leu Gln Lys Ile Tyr Gly Lys
                 645                 650                 655    
 Asp Lys Phe Tyr Glu Cys Arg Val Cys Lys Glu Thr Phe Leu His Ser
             660                 665                 670        
 Ser Ala Leu Ile Glu His Gln Lys Ile His Phe Gly Asp Asp Lys Asp
         675                 680                 685            
 Asn Glu Arg Glu His Glu Arg Glu Arg Glu Arg Glu Arg Gly Glu Thr
     690                 695                 700                
 Phe Arg Pro Ser Pro Ala Leu Asn Glu Phe Gln Lys Met Tyr Gly Lys
 705                 710                 715                 720
 Glu Lys Met Tyr Glu Cys Lys Val Cys Gly Glu Thr Phe Leu His Ser
                 725                 730                 735    
 Ser Ser Leu Lys Glu His Gln Lys Ile His Thr Arg Gly Asn Pro Phe
             740                 745                 750        
 Glu Asn Lys Gly Lys Val Cys Glu Glu Thr Phe Ile Pro Gly Gln Ser
         755                 760                 765            
 Leu Lys Arg Arg Gln Lys Thr Tyr Asn Lys Glu Lys Leu Cys Asp Phe
     770                 775                 780                
 Thr Asp Gly Arg Asp Ala Phe Met Gln Ser Ser Glu Leu Ser Glu His
 785                 790                 795                 800
 Gln Lys Ile His Ser Arg Lys Asn Leu Phe Glu Gly Arg Gly Tyr Glu
                 805                 810                 815    
 Lys Ser Val Ile His Ser Gly Pro Phe Thr Glu Ser Gln Lys Ser His
             820                 825                 830        
 Thr Ile Thr Arg Pro Leu Glu Ser Asp Glu Asp Glu Lys Ala Phe Pro
         835                 840                 845            
 Ile Ser Ser Asn Pro Tyr Glu Asn Gln Lys Ile Pro Thr Lys Glu Asn
     850                 855                 860                
 Val Tyr Glu Ala Lys Ser Tyr Glu Arg Ser Val Ile His Ser Leu Ala
 865                 870                 875                 880
 Ser Val Glu Ala Gln Lys Ser His Ser Val Ala Gly Pro Ser Lys Pro
                 885                 890                 895    
 Lys Val Met Ala Glu Ser Thr Ile Gln Ser Phe Asp Ala Ile Asn His
             900                 905                 910        
 Gln Arg Val Arg Ala Gly Gly Asn Thr Ser Glu Gly Arg Glu Tyr Ser
         915                 920                 925            
 Arg Ser Val Ile His Ser Leu Val Ala Ser Lys Pro Pro Arg Ser His
     930                 935                 940                
 Asn Gly Asn Glu Leu Val Glu Ser Asn Glu Lys Gly Glu Ser Ser Ile
 945                 950                 955                 960
 Tyr Ile Ser Asp Leu Asn Asp Lys Arg Gln Lys Ile Pro Ala Arg Glu
                 965                 970                 975    
 Asn Pro Cys Glu Gly Gly Ser Lys Asn Arg Asn Tyr Glu Asp Ser Val
             980                 985                 990        
 Ile Gln Ser Val Phe Arg Ala Lys Pro Gln Lys Ser Val Pro Gly Glu
         995                1000                1005            
 Gly Ser Gly Glu Phe Lys Lys Asp Gly Glu Phe Ser Val Pro Ser Ser
    1010                1015                1020                
 Asn Val Arg Glu Tyr Gln Lys Ala Arg Ala Lys Lys Lys Tyr Ile Glu
1025                1030                1035                1040
 His Arg Ser Asn Glu Thr Ser Val Ile His Ser Leu Pro Phe Gly Glu
                1045                1050                1055    
 Gln Thr Phe Arg Pro Arg Gly Met Leu Tyr Glu Cys Gln Glu Cys Gly
            1060                1065                1070        
 Glu Cys Phe Ala His Ser Ser Asp Leu Thr Glu His Gln Lys Ile His
        1075                1080                1085            
 Asp Arg Glu Lys Pro Ser Gly Ser Arg Asn Tyr Glu Trp Ser Val Ile
    1090                1095                1100                
 Arg Ser Leu Ala Pro Thr Asp Pro Gln Thr Ser Tyr Ala Gln Glu Gln
1105                1110                1115                1120
 Tyr Ala Lys Glu Gln Ala Arg Asn Lys Cys Lys Asp Phe Arg Gln Phe
                1125                1130                1135    
 Phe Ala Thr Ser Glu Asp Leu Asn Thr Asn Gln Lys Ile Tyr Asp Gln
            1140                1145                1150        
 Glu Lys Ser His Gly Glu Glu Ser Gln Gly Glu Asn Thr Asp Gly Glu
        1155                1160                1165            
 Glu Thr His Ser Glu Glu Thr His Gly Gln Glu Thr Ile Glu Asp Pro
    1170                1175                1180                
 Val Ile Gln Gly Ser Asp Met Glu Asp Pro Gln Lys Asp Asp Pro Asp
1185                1190                1195                1200
 Asp Lys Ile Tyr Glu Cys Glu Asp Cys Gly Leu Gly Phe Val Asp Leu
                1205                1210                1215    
 Thr Asp Leu Thr Asp His Gln Lys Val His Ser Arg Lys Cys Leu Val
            1220                1225                1230        
 Asp Ser Arg Glu Tyr Thr His Ser Val Ile His Thr His Ser Ile Ser
        1235                1240                1245            
 Glu Tyr Gln Arg Asp Tyr Thr Gly Glu Gln Leu Tyr Glu Cys Pro Lys
    1250                1255                1260                
 Cys Gly Glu Ser Phe Ile His Ser Ser Phe Leu Phe Glu His Gln Arg
1265                1270                1275                1280
 Ile His Glu Gln Asp Gln Leu Tyr Ser Met Lys Gly Cys Asp Asp Gly
                1285                1290                1295    
 Phe Ile Ala Leu Leu Pro Met Lys Pro Arg Arg Asn Arg Ala Ala Glu
            1300                1305                1310        
 Arg Asn Pro Ala Leu Ala Gly Ser Ala Ile Arg Cys Leu Leu Cys Gly
        1315                1320                1325            
 Gln Gly Phe Ile His Ser Ser Ala Leu Asn Glu His Met Arg Leu His
    1330                1335                1340                
 Arg Glu Asp Asp Leu Leu Glu Gln Ser Gln Met Ala Glu Glu Ala Ile
1345                1350                1355                1360
 Ile Pro Gly Leu Ala Leu Thr Glu Phe Gln Arg Ser Gln Thr Glu Glu
                1365                1370                1375    
 Arg Leu Phe Glu Cys Ala Val Cys Gly Glu Ser Phe Val Asn Pro Ala
            1380                1385                1390        
 Glu Leu Ala Asp His Val Thr Val His Lys Asn Glu Pro Tyr Glu Tyr
        1395                1400                1405            
 Gly Ser Ser Tyr Thr His Thr Ser Phe Leu Thr Glu Pro Leu Lys Gly
    1410                1415                1420                
 Ala Ile Pro Phe Tyr Glu Cys Lys Asp Cys Gly Lys Ser Phe Ile His
1425                1430                1435                1440
 Ser Thr Val Leu Thr Lys His Lys Glu Leu His Leu Glu Glu Glu Glu
                1445                1450                1455    
 Glu Asp Glu Ala Ala Ala Ala Ala Gly Ala Ala Ala Gln Glu Val Glu
            1460                1465                1470        
 Ala Asn Val His Val Pro Gln Val Val Leu Arg Ile Gln Gly Leu Asn
        1475                1480                1485            
 Val Glu Ala Ala Glu Pro Glu Val Glu Ala Ala Glu Pro Glu Val Glu
    1490                1495                1500                
 Ala Ala Glu Pro Glu Val Glu Ala Ala Glu Pro Asn Gly Glu Ala Glu
1505                1510                1515                1520
 Gly Pro Asp Gly Glu Ala Ala Glu Pro Ile Gly Glu Ala Gly Gln Pro
                1525                1530                1535    
 Asn Gly Glu Ala Glu Gln Pro Asn Gly Asp Ala Asp Glu Pro Asp Gly
            1540                1545                1550        
 Ala Gly Ile Glu Asp Pro Glu Glu Arg Ala Glu Glu Pro Glu Gly Lys
        1555                1560                1565            
 Ala Glu Glu Pro Glu Gly Asp Ala Asp Glu Pro Asp Gly Val Gly Ile
    1570                1575                1580                
 Glu Asp Pro Glu Glu Gly Glu Asp Gln Glu Ile Gln Val Glu Glu Pro
1585                1590                1595                1600
 Tyr Tyr Asp Cys His Glu Cys Thr Glu Thr Phe Thr Ser Ser Thr Ala
                1605                1610                1615    
 Phe Ser Glu His Leu Lys Thr His Ala Ser Met Ile Ile Phe Glu Pro
            1620                1625                1630        
 Ala Asn Ala Phe Gly Glu Cys Ser Gly Tyr Ile Glu Arg Ala Ser Thr
        1635                1640                1645            
 Ser Thr Gly Gly Ala Asn Gln Ala Asp Glu Lys Tyr Phe Lys Cys Asp
    1650                1655                1660                
 Val Cys Gly Gln Leu Phe Asn Asp Arg Leu Ser Leu Ala Arg His Gln
1665                1670                1675                1680
 Asn Thr His Thr Gly
                1685



      <210> 986
      <211> 297
      <212> PRT
      <213> Homo sapiens


      <400> 986
 Met Ala Lys Met Phe Ser Phe Asn Asp Ser Asn Ala Ala Arg Ile His
   1               5                  10                  15    
 Gln Asp Thr Gln Glu Leu Met Cys Phe Gly Arg Trp Cys Trp Lys Asp
              20                  25                  30        
 Gly Ile Pro Gly Ser Leu Cys Ile Pro Cys Ser Gln Pro Met Ser Ile
          35                  40                  45            
 Ser Thr Val Gln Gln Gly Lys Lys Ala Ala Ser Ser His Tyr Ser Arg
      50                  55                  60                
 Gly Gly Ala Lys Tyr Glu Gly Glu Ala Val Lys Arg Ser Leu Val Glu
  65                  70                  75                  80
 Ser Tyr Thr His Pro Asn Ser Asn Glu Thr Glu Arg Arg Glu Asn Ile
                  85                  90                  95    
 Asp Thr Val Met Asn Cys Phe Ser Thr Glu Asp Phe Asp Phe Val Thr
             100                 105                 110        
 Leu Tyr Tyr Arg Glu Pro Asp Asn Val Gly His Arg Phe Gly Pro Glu
         115                 120                 125            
 Ala Glu Lys Arg Lys Leu Met Ile Gln Gln Ile Gly Arg Thr Ile Val
     130                 135                 140                
 Tyr Leu Val Gly Ala Thr Glu Lys His Ser Leu Gln Ser Thr Ser Ala
 145                 150                 155                 160
 Pro Trp Gly Asp His Arg Glu Glu Glu Thr Gln Arg Gln Gln Asp Pro
                 165                 170                 175    
 Leu Thr Asn Tyr Ile Lys Phe Arg Val Trp Val Lys Phe Asp Ile Ala
             180                 185                 190        
 Gly Tyr Gly Gly Phe Gly Leu Pro Leu Pro Lys Leu Gly Gln Glu Glu
         195                 200                 205            
 Ala Leu Tyr Gln Ala Leu Lys Asn Ala His Pro His Leu Gln Val Tyr
     210                 215                 220                
 Lys Lys Glu Glu Phe Pro Glu His Phe His Leu Ala Lys His Asp Arg
 225                 230                 235                 240
 Val Leu Pro Ile Val Ile Phe Gln Arg Ile Ile Met Cys Phe Asn Lys
                 245                 250                 255    
 Gly Ser His Gly Phe Asp Asn Val Leu Met Asp Met Asn Ile Ile Phe
             260                 265                 270        
 Arg Ala Phe Gly Pro Asp Phe Lys Arg Asn Arg Leu Ala Glu Pro Phe
         275                 280                 285            
 Asn Ser Ile His Ile Tyr Pro Phe Val
     290                 295        



      <210> 987
      <211> 228
      <212> PRT
      <213> Homo sapiens


      <400> 987
 Met Gly Ser Arg Glu Ser Val Glu Gly Ser Gly Arg Ser Gly Gly Ser
   1               5                  10                  15    
 Pro Phe Leu Pro Phe Ser Trp Phe Thr Asp Ser Gly Lys Gly Ser Ala
              20                  25                  30        
 Ser Ser Gly Ser Thr Thr Ser Pro Thr Cys Ser Pro Lys His Glu Gly
          35                  40                  45            
 Phe Ser Pro Lys Lys Ser Ala Ser Gln Ala Gln Leu Leu Ala His Ala
      50                  55                  60                
 Gln Glu Ala Leu Ser Asn Ser Trp Cys Leu Val Gln Asp Phe Gly Ser
  65                  70                  75                  80
 Thr Gln Ile Gly Met Glu Ser Thr Leu Ser Asp Asp Ser Thr Pro Pro
                  85                  90                  95    
 Ser Ser Ser Pro Lys Ile Pro Ser Gly Pro Trp Gln Glu Ala Lys Cys
             100                 105                 110        
 Ser Tyr Pro Tyr His Thr Leu Ser Gln Ser Ser Asp Glu Phe Leu Asp
         115                 120                 125            
 Glu Pro Leu Pro Pro Val His His Trp Thr Ser Gln Gln Val Gly Gln
     130                 135                 140                
 Trp Leu Gln Ser Leu Asn Leu Glu Gln Tyr Ala Ala Glu Phe Ala Ala
 145                 150                 155                 160
 Arg Gln Val Asp Gly Pro Gln Leu Leu Gln Leu Asp Gly Ser Lys Leu
                 165                 170                 175    
 Lys Ser Leu Gly Leu Ser Asn Ser His Asp Arg Ala Leu Val Lys Arg
             180                 185                 190        
 Lys Leu Lys Glu Met Ala Ala Ala Ala Glu Lys Glu Arg Lys Ala Gln
         195                 200                 205            
 Glu Lys Ala Ala Arg Gln Arg Glu Lys Leu Arg Arg Arg Glu Gln Glu
     210                 215                 220                
 Ala Lys Lys Ser
 225            



      <210> 988
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 988
 Met Val Lys Ile Gln Pro Leu Trp Lys Arg Val Trp Arg Phe His Asn
   1               5                  10                  15    
 Lys Ser Lys Leu Glu Leu Pro Cys Asp Pro Ala Ile Ser Leu Leu Ser
              20                  25                  30        
 Met Tyr Pro Lys Glu Met Lys Ser Val Cys Gln Arg Asp Val Cys Thr
          35                  40                  45            
 Pro Arg Leu Ser Thr Ala Pro Leu Thr Ile Ala Gly Met Trp Asn Pro
      50                  55                  60                
 Pro Lys Arg Ser Ser Met Asp
  65                  70    



      <210> 989
      <211> 343
      <212> PRT
      <213> Homo sapiens


      <400> 989
 Met Ser Leu Ser Cys Glu Arg Leu Arg Ala Leu Leu Pro Gln Phe Asp
   1               5                  10                  15    
 Gly Arg Arg Glu Asp Met Ala Ser Val Leu Glu Met Ser Val Gln Phe
              20                  25                  30        
 Leu Arg Leu Ala Ser Ala Leu Gly Pro Ser Gln Glu Gln His Ala Val
          35                  40                  45            
 Ser Cys Lys Gly Arg Arg Arg Gln Ser Ser Gly Ile Thr Val Met Gly
      50                  55                  60                
 His Leu Thr Thr Leu Gln Ala Ile Leu Ala Ser Ser Lys Glu Met Trp
  65                  70                  75                  80
 His Ser Leu Gln Glu Asp Val Leu Gln Leu Thr Leu Ser Ser Gln Ile
                  85                  90                  95    
 Gln Ala Gly Val Pro Asp Pro Gly Thr Gly Ala Ser Ser Gly Thr Arg
             100                 105                 110        
 Thr Pro Asp Val Lys Ala Phe Leu Glu Ser Pro Trp Ser Leu Asp Pro
         115                 120                 125            
 Ala Ser Ala Ser Pro Glu Pro Val Pro His Ile Leu Ala Ser Ser Arg
     130                 135                 140                
 Gln Trp Asp Pro Ala Ser Cys Thr Ser Leu Gly Thr Asp Lys Cys Glu
 145                 150                 155                 160
 Ala Leu Leu Gly Leu Cys Gln Val Arg Gly Gly Leu Pro Pro Phe Ser
                 165                 170                 175    
 Glu Pro Ser Ser Leu Val Pro Trp Pro Pro Gly Arg Ser Leu Pro Lys
             180                 185                 190        
 Ala Val Arg Pro Pro Leu Ser Trp Pro Pro Phe Ser Gln Gln Gln Thr
         195                 200                 205            
 Leu Pro Val Met Ser Gly Glu Ala Leu Gly Trp Leu Gly Gln Ala Gly
     210                 215                 220                
 Pro Leu Ala Met Gly Ala Ala Pro Leu Gly Glu Pro Ala Lys Glu Asp
 225                 230                 235                 240
 Pro Met Leu Ala Gln Glu Ala Gly Ser Ala Leu Gly Ser Asp Val Asp
                 245                 250                 255    
 Asp Gly Thr Ser Phe Leu Leu Thr Ala Gly Pro Ser Ser Trp Pro Gly
             260                 265                 270        
 Ser Leu Glu Gly Arg Gly Gly Ser Gly Pro Ala Trp Ala Pro Ala Glu
         275                 280                 285            
 Ser Ser Pro Leu Asp Val Gly Glu Pro Gly Phe Leu Gly Asp Pro Glu
     290                 295                 300                
 Leu Gly Ser Gln Glu Leu Gln Asp Ser Pro Leu Glu Pro Trp Gly Leu
 305                 310                 315                 320
 Asp Val Asp Cys Ala Gly Leu Ala Leu Lys Asp Glu Val Glu Ser Ile
                 325                 330                 335    
 Phe Pro Asp Phe Phe Ala Cys
             340            



      <210> 990
      <211> 99
      <212> PRT
      <213> Homo sapiens


      <400> 990
 Met Gly Arg Ile Gln Ser Thr Lys Ala Glu Asn Ser Lys Asn Glu Ser
   1               5                  10                  15    
 Thr Ser Ser Pro Pro Lys Glu His Ser Thr Ser Pro Ala Thr Glu Gln
              20                  25                  30        
 Ser Arg Met Glu Asn Asp Phe Asp Glu Leu Arg Glu Asp Phe Arg Arg
          35                  40                  45            
 Ser Val Ile Thr Asn Phe Ser Glu Leu Lys Glu Asp Val Arg Thr Leu
      50                  55                  60                
 Cys Lys Glu Ala Lys Asn Leu Glu Lys Arg Leu Asp Glu Trp Leu Thr
  65                  70                  75                  80
 Arg Ile Asn Ser Ile Glu Lys Thr Leu Asn Asp Leu Met Glu Leu Lys
                  85                  90                  95    
 Thr Met Ala
            



      <210> 991
      <211> 199
      <212> PRT
      <213> Homo sapiens


      <400> 991
 Met Gly Asn Tyr Gln Glu Tyr Leu Lys Thr Leu Ala Ser Pro Leu Arg
   1               5                  10                  15    
 Glu Ile Asp Pro Asp Gln Pro Lys Arg Leu His Thr Phe Gly Asn Pro
              20                  25                  30        
 Phe Lys Gln Asp Lys Lys Gly Met Met Ile Asp Glu Ala Asp Glu Phe
          35                  40                  45            
 Val Ala Gly Pro Gln Asn Lys Val Lys Arg Pro Gly Glu Pro Asn Ser
      50                  55                  60                
 Pro Met Ser Ser Lys Arg Arg Arg Asn Ala Thr Ile Ile His Asp Gly
  65                  70                  75                  80
 His Glu Glu Lys Met Glu Asn Gly Gln Ile Thr Pro Asp Gly Phe Leu
                  85                  90                  95    
 Ser Lys Ser Ala Pro Ser Glu Leu Ile Asn Met Thr Gly Asp Leu Met
             100                 105                 110        
 Pro Pro Asn Gln Val Asp Ser Leu Ser Asp Asp Phe Thr Ser Leu Ser
         115                 120                 125            
 Lys Asp Gly Leu Ile Gln Lys Pro Gly Ser Asn Ala Phe Val Gly Gly
     130                 135                 140                
 Ala Lys Asn Cys Ser Leu Ser Val Asp Asp Gln Lys Asp Pro Val Ala
 145                 150                 155                 160
 Ser Thr Leu Gly Ala Met Pro Asn Thr Leu Gln Ile Thr Pro Ala Met
                 165                 170                 175    
 Ala Gln Gly Ile Asn Ala Asp Ile Lys His Gln Leu Met Lys Glu Val
             180                 185                 190        
 Arg Lys Phe Gly Arg Ser Lys
         195                



      <210> 992
      <211> 213
      <212> PRT
      <213> Homo sapiens


      <400> 992
 Met Glu Thr Tyr Ala Glu Val Gly Lys Glu Gly Lys Pro Ser Cys Ala
   1               5                  10                  15    
 Ser Val Asp Leu Gln Gly Asp Ser Ser Leu Gln Val Glu Ile Ser Asp
              20                  25                  30        
 Ala Val Ser Glu Arg Asp Lys Val Lys Phe Thr Val Gln Thr Lys Ser
          35                  40                  45            
 Cys Leu Pro His Phe Ala Gln Thr Glu Phe Ser Val Val Arg Gln His
      50                  55                  60                
 Glu Glu Phe Ile Trp Leu His Asp Ala Tyr Val Glu Asn Glu Glu Tyr
  65                  70                  75                  80
 Ala Gly Leu Ile Ile Pro Pro Ala Pro Pro Arg Pro Asp Phe Glu Ala
                  85                  90                  95    
 Ser Arg Glu Lys Leu Gln Lys Leu Gly Glu Gly Asp Ser Ser Val Thr
             100                 105                 110        
 Arg Glu Glu Phe Ala Lys Met Lys Gln Glu Leu Glu Ala Glu Tyr Leu
         115                 120                 125            
 Ala Ile Phe Lys Lys Thr Val Ala Met His Glu Val Phe Leu Gln Arg
     130                 135                 140                
 Leu Ala Ala His Pro Thr Leu Arg Arg Asp His Asn Phe Phe Val Phe
 145                 150                 155                 160
 Leu Glu Tyr Gly Gln Asp Leu Ser Val Arg Gly Lys Asn Arg Lys Glu
                 165                 170                 175    
 Leu Leu Gly Gly Phe Leu Arg Asn Ile Val Lys Ser Ala Asp Glu Ala
             180                 185                 190        
 Leu Ile Thr Gly Met Ser Gly Leu Lys Ala Trp Gln Thr Ile Ile Ser
         195                 200                 205            
 Leu Ser Gln Leu Arg
     210            



      <210> 993
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 993
 Met Ser Lys Leu Ser Phe Arg Ala Arg Ala Leu Asp Ala Ala Lys Pro
   1               5                  10                  15    
 Leu Pro Ile Tyr Arg Gly Lys Asp Met Pro Asp Leu Asn Asp Cys Val
              20                  25                  30        
 Ser Ile Asn Arg Ala Val Pro Gln Met Pro Thr Gly Met Glu Lys Glu
          35                  40                  45            
 Glu Glu Ser Glu His His Leu Gln Arg Ala Ile Ser Ala Gln Gln Val
      50                  55                  60                
 Phe Arg Glu Lys Lys Glu Ser Met Val Ile Pro Val Pro Glu Ala Glu
  65                  70                  75                  80
 Ser Asn Val Asn Tyr Tyr Asn Arg Leu Tyr Lys Gly Glu Phe Lys Gln
                  85                  90                  95    
 Pro Lys Gln Phe Ile His Ile Gln Leu Lys Leu His Leu Lys Leu Leu
             100                 105                 110        
 Leu Phe Arg Ile Glu Val Leu Phe Phe
         115                 120    



      <210> 994
      <211> 180
      <212> PRT
      <213> Homo sapiens


      <400> 994
 Met Gly Pro Ile Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Thr
   1               5                  10                  15    
 Gly Pro Gln Gly Glu Pro Gly Val Arg Gly Ile Arg Gly Trp Lys Gly
              20                  25                  30        
 Asp Arg Gly Glu Lys Gly Lys Ile Gly Glu Thr Leu Val Leu Pro Lys
          35                  40                  45            
 Ser Ala Phe Thr Val Gly Leu Thr Val Leu Ser Lys Phe Pro Ser Ser
      50                  55                  60                
 Asp Met Pro Ile Lys Phe Asp Lys Ile Leu Tyr Asn Glu Phe Asn His
  65                  70                  75                  80
 Tyr Asp Thr Ala Ala Gly Lys Phe Thr Cys His Ile Ala Gly Val Tyr
                  85                  90                  95    
 Tyr Phe Thr Tyr His Ile Thr Val Phe Ser Arg Asn Val Gln Val Ser
             100                 105                 110        
 Leu Val Lys Asn Gly Val Lys Ile Leu His Thr Lys Asp Ala Tyr Met
         115                 120                 125            
 Ser Ser Glu Asp Gln Ala Ser Gly Gly Ile Val Leu Gln Leu Lys Leu
     130                 135                 140                
 Gly Asp Glu Val Trp Leu Gln Val Thr Gly Gly Glu Arg Phe Asn Gly
 145                 150                 155                 160
 Leu Phe Ala Asp Glu Asp Asp Asp Thr Thr Phe Thr Gly Phe Leu Leu
                 165                 170                 175    
 Phe Ser Ser Pro
             180



      <210> 995
      <211> 897
      <212> PRT
      <213> Homo sapiens


      <400> 995
 Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser Arg Asp Ser Gln Gly
   1               5                  10                  15    
 His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala
              20                  25                  30        
 Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly Arg Met Asn Gln Gly
          35                  40                  45            
 Thr Ala Arg Leu Ala Ser Leu Met Asn Leu Gly Met Ser Ser Ser Leu
      50                  55                  60                
 Asn Gln Gln Gly Ala His Ser Ala Leu Ser Ser Ala Ser Thr Ser Ser
  65                  70                  75                  80
 His Asn Leu Gln Ser Ile Phe Asn Ile Gly Ser Arg Gly Pro Leu Pro
                  85                  90                  95    
 Leu Ser Ser Gln His Arg Gly Asp Ala Asp Gln Ala Ser Asn Ile Leu
             100                 105                 110        
 Ala Ser Phe Gly Leu Ser Ala Arg Asp Leu Asp Glu Leu Ser Arg Tyr
         115                 120                 125            
 Pro Glu Asp Lys Ile Thr Pro Glu Asn Leu Pro Gln Ile Leu Leu Gln
     130                 135                 140                
 Leu Lys Arg Arg Arg Thr Glu Glu Gly Pro Thr Leu Ser Tyr Gly Arg
 145                 150                 155                 160
 Asp Gly Arg Ser Ala Thr Arg Glu Pro Pro Tyr Arg Val Pro Arg Asp
                 165                 170                 175    
 Asp Trp Glu Glu Lys Arg His Phe Arg Arg Asp Ser Phe Asp Asp Arg
             180                 185                 190        
 Gly Pro Ser Leu Asn Pro Val Leu Asp Tyr Asp His Gly Ser Arg Ser
         195                 200                 205            
 Gln Glu Ser Gly Tyr Tyr Asp Arg Met Asp Tyr Glu Asp Asp Arg Leu
     210                 215                 220                
 Arg Asp Gly Glu Arg Cys Arg Asp Asp Ser Phe Phe Gly Glu Thr Ser
 225                 230                 235                 240
 His Asn Tyr His Lys Phe Asp Ser Glu Tyr Glu Arg Met Gly Arg Gly
                 245                 250                 255    
 Ser Gly Pro Leu Gln Glu Arg Ser Leu Phe Glu Lys Lys Arg Gly Ala
             260                 265                 270        
 Pro Ser Ser Ser Asn Ile Val Asp Val His Trp Thr Leu Thr Glu Arg
         275                 280                 285            
 Val Ile Pro Ile Cys Ala Leu Tyr Val Ile Gly Gln Val Ile Leu Ile
     290                 295                 300                
 Arg Ser Gly Val Asn Ile Ser Met Glu Gln Val Thr Val Val Asp Ala
 305                 310                 315                 320
 Ser Phe Phe Leu Lys Ser Thr Gln Asn Gly Ile Leu Thr Met Ile Gln
                 325                 330                 335    
 Asp Thr Gln Trp Val Ile His Ser Cys Cys Ser Ser Leu Gln Ile Gln
             340                 345                 350        
 His Gln Glu Phe Trp Asp Leu His Leu Pro His Phe Ile Leu Gly Asp
         355                 360                 365            
 Gln Gln Leu Asp Gln Glu Glu Ile Trp Val Leu Glu Met Glu Thr Cys
     370                 375                 380                
 Lys Asp Leu Asp Thr Cys Arg Lys Ala Glu Trp Lys Leu Ser Arg Val
 385                 390                 395                 400
 Val His Ile Met Gly Phe Ser Thr Glu Glu Lys Thr Leu Arg Tyr Gln
                 405                 410                 415    
 Leu Leu Gln Leu Val Glu Pro Phe Gly Val Ile Ser Asn His Leu Ile
             420                 425                 430        
 Leu Asn Lys Ile Asn Glu Ala Phe Ile Glu Met Ala Thr Thr Glu Asp
         435                 440                 445            
 Ala Gln Ala Ala Val Asp Tyr Tyr Thr Thr Thr Pro Ala Leu Val Phe
     450                 455                 460                
 Gly Lys Pro Val Arg Val His Leu Ser Gln Lys Tyr Lys Arg Ile Lys
 465                 470                 475                 480
 Lys Pro Glu Gly Lys Pro Asp Gln Lys Phe Asp Gln Lys Gln Glu Leu
                 485                 490                 495    
 Gly Arg Val Ile His Leu Ser Asn Leu Pro His Ser Gly Tyr Ser Asp
             500                 505                 510        
 Ser Ala Val Leu Lys Leu Ala Glu Pro Tyr Gly Lys Ile Lys Asn Tyr
         515                 520                 525            
 Ile Leu Met Arg Met Lys Ser Gln Ala Phe Ile Glu Met Glu Thr Arg
     530                 535                 540                
 Glu Asp Ala Met Ala Met Val Asp His Cys Leu Lys Lys Ala Leu Trp
 545                 550                 555                 560
 Phe Gln Gly Arg Cys Val Lys Val Asp Leu Ser Glu Lys Cys Lys Lys
                 565                 570                 575    
 Leu Val Leu Arg Ile Pro Asn Arg Gly Ile Asp Leu Leu Lys Lys Asp
             580                 585                 590        
 Lys Ser Arg Lys Arg Ser Tyr Ser Pro Asp Gly Lys Glu Ser Pro Ser
         595                 600                 605            
 Asp Lys Lys Ser Lys Thr Asp Gly Ser Gln Lys Thr Glu Ser Ser Thr
     610                 615                 620                
 Glu Gly Lys Glu Gln Glu Glu Lys Ser Gly Glu Asp Gly Glu Lys Asp
 625                 630                 635                 640
 Thr Lys Asp Asp Gln Thr Glu Gln Glu Pro Asn Met Leu Leu Glu Ser
                 645                 650                 655    
 Glu Asp Glu Leu Leu Val Asp Glu Glu Glu Ala Ala Ala Leu Leu Glu
             660                 665                 670        
 Ser Gly Ser Ser Val Gly Asp Glu Thr Asp Leu Ala Asn Leu Gly Asp
         675                 680                 685            
 Val Ala Ser Asp Gly Lys Lys Glu Pro Ser Asp Lys Ala Val Lys Lys
     690                 695                 700                
 Asp Gly Ser Ala Ser Ala Ala Ala Lys Lys Lys Leu Lys Lys Arg Arg
 705                 710                 715                 720
 Phe Pro Gly Ser Met Glu Gly Phe Val Thr Leu Asp Glu Val Gly Asp
                 725                 730                 735    
 Glu Glu Asp Ser Glu Leu Gln Lys Leu Arg Lys Ser Gly Met Ala Phe
             740                 745                 750        
 Lys Ser Gly Asp Lys Asn Asp Asp Gly Leu Val Glu Ile Lys Val Asp
         755                 760                 765            
 Lys Ile Glu Glu Leu Asp Gln Glu Asn Glu Ala Ala Leu Glu Asn Gly
     770                 775                 780                
 Ile Lys Asn Glu Glu Asn Thr Glu Pro Gly Ala Glu Ser Ser Glu Asn
 785                 790                 795                 800
 Ala Asp Asp Pro Asn Lys Asp Thr Ser Glu Asn Ala Asp Gly Gln Ser
                 805                 810                 815    
 Asp Glu Asn Lys Asp Asp Tyr Thr Ile Pro Asp Glu Tyr Arg Ile Gly
             820                 825                 830        
 Pro Tyr Gln Pro Asn Val Pro Val Gly Ile Asp Tyr Val Ile Pro Lys
         835                 840                 845            
 Thr Gly Phe Tyr Cys Lys Leu Cys Ser Leu Phe Tyr Thr Asn Glu Glu
     850                 855                 860                
 Val Ala Lys Asn Thr His Cys Ser Ser Leu Pro His Tyr Gln Lys Leu
 865                 870                 875                 880
 Lys Lys Phe Leu Asn Lys Leu Ala Glu Glu Arg Arg Gln Lys Lys Glu
                 885                 890                 895    
 Thr
    



      <210> 996
      <211> 99
      <212> PRT
      <213> Homo sapiens


      <400> 996
 Met Val Gln Asn Gln Ser Gly Pro Gly Phe Arg Gly Pro Ser Gly Ser
   1               5                  10                  15    
 Leu Gly Cys Ser Phe Phe Pro Arg Ser Leu Gly Arg Val Leu Pro Pro
              20                  25                  30        
 Gly Cys Gln Arg Pro Gly Ala His Ala Asp Ser Ser Pro Pro Pro Thr
          35                  40                  45            
 Pro Gln Phe Ala Glu Gly His Gly Ala Ala Ala Pro Ala Gly Glu Glu
      50                  55                  60                
 Val Ala Gly Arg Tyr Ile Gly Arg Arg Leu Lys Pro His Pro Trp Arg
  65                  70                  75                  80
 Arg Leu Arg Glu Arg Ser Pro Thr Trp Thr His Gly Arg Leu Arg Asp
                  85                  90                  95    
 Ala Pro Ala
            



      <210> 997
      <211> 63
      <212> PRT
      <213> Homo sapiens


      <400> 997
 Met Leu Trp Gly Ser Ser Ser Ile Val Cys Ile Leu His Arg His Lys
   1               5                  10                  15    
 Arg Arg Val Gln His Ile His Arg Thr Ser Val Ser Pro Thr Ser Ser
              20                  25                  30        
 Pro Glu Ser Gly Ala Thr Lys Thr Ile Leu Leu Val Ser Thr Phe Val
          35                  40                  45            
 Ser Phe Tyr Thr Leu Ser Ser Pro Phe Lys Phe Val Trp Leu Phe
      50                  55                  60            



      <210> 998
      <211> 445
      <212> PRT
      <213> Homo sapiens


      <400> 998
 Met Pro Leu Gln Gly Ser Val Ser Phe Lys Asp Val Thr Val Asp Phe
   1               5                  10                  15    
 Thr Gln Glu Glu Trp Gln Gln Leu Asp Pro Ala Gln Lys Ala Leu Tyr
              20                  25                  30        
 Arg Asp Val Met Leu Glu Asn Tyr Cys His Phe Val Ser Val Gly Phe
          35                  40                  45            
 His Met Ala Lys Pro Asp Met Ile Arg Lys Leu Glu Gln Gly Glu Glu
      50                  55                  60                
 Leu Trp Thr Gln Arg Ile Phe Pro Ser Tyr Ser Tyr Leu Val Asn Leu
  65                  70                  75                  80
 His Lys Gln Thr Glu Arg Val Leu Ser Gly Lys Gln Glu Leu Ile Gln
                  85                  90                  95    
 His Gln Lys Val Gln Ala Pro Glu Gln Pro Phe Asp His Asn Glu Cys
             100                 105                 110        
 Glu Lys Ser Phe Leu Met Lys Gly Met Leu Phe Thr His Thr Arg Ala
         115                 120                 125            
 His Arg Gly Glu Arg Thr Phe Glu Tyr Asn Lys Asp Gly Ile Ala Phe
     130                 135                 140                
 Ile Glu Lys Ser Ser Leu Ser Val His Pro Ser Asn Leu Met Glu Lys
 145                 150                 155                 160
 Lys Pro Ser Ala Tyr Asn Lys Tyr Gly Lys Phe Leu Cys Arg Lys Pro
                 165                 170                 175    
 Val Phe Ile Met Pro Gln Arg Pro Gln Thr Glu Glu Lys Pro Phe His
             180                 185                 190        
 Cys Pro Tyr Cys Gly Asn Asn Phe Arg Arg Lys Ser Tyr Leu Ile Glu
         195                 200                 205            
 His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Val Cys Asn Gln Cys
     210                 215                 220                
 Gly Lys Ala Phe Arg Gln Lys Thr Ala Leu Thr Leu His Glu Lys Thr
 225                 230                 235                 240
 His Ile Glu Gly Lys Pro Phe Ile Cys Ile Asp Cys Gly Lys Ser Phe
                 245                 250                 255    
 Arg Gln Lys Ala Thr Leu Thr Arg His His Lys Thr His Thr Gly Glu
             260                 265                 270        
 Lys Ala Tyr Glu Cys Pro Gln Cys Gly Ser Ala Phe Arg Lys Lys Ser
         275                 280                 285            
 Tyr Leu Ile Asp His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Gln
     290                 295                 300                
 Cys Asn Glu Cys Gly Lys Ala Phe Ile Gln Lys Thr Thr Leu Thr Val
 305                 310                 315                 320
 His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Ile Cys Asn Glu Cys
                 325                 330                 335    
 Gly Lys Ser Phe Cys Gln Lys Thr Thr Leu Thr Leu His Gln Arg Ile
             340                 345                 350        
 His Thr Gly Glu Lys Pro Tyr Ile Cys Asn Glu Cys Gly Lys Ser Phe
         355                 360                 365            
 Arg Gln Lys Ala Ile Leu Thr Val His His Arg Ile His Thr Gly Glu
     370                 375                 380                
 Lys Ser Asn Gly Cys Pro Gln Cys Gly Lys Ala Phe Ser Arg Lys Ser
 385                 390                 395                 400
 Asn Leu Ile Arg His Gln Lys Thr His Thr Gly Glu Lys Pro Tyr Glu
                 405                 410                 415    
 Cys Lys Gln Cys Gly Lys Phe Phe Ser Cys Lys Ser Asn Leu Ile Val
             420                 425                 430        
 His Gln Lys Thr His Lys Val Glu Thr Thr Gly Ile Gln
         435                 440                 445



      <210> 999
      <211> 63
      <212> PRT
      <213> Homo sapiens


      <400> 999
 Met Ser Leu Thr Pro Gln Gly Leu Ala Trp Ile Pro Lys Gln Leu Gln
   1               5                  10                  15    
 Gln Ile Ser Ser Glu Pro Gly Thr Glu Asn Ser Val Leu Leu Leu Leu
              20                  25                  30        
 Arg Lys Glu Val Phe Arg Met Pro Arg Ala Glu Gln Pro Val Ile Thr
          35                  40                  45            
 Leu Phe Val Leu Thr Trp Val Arg Thr Leu Met Met Gln Trp Leu
      50                  55                  60            



      <210> 1000
      <211> 569
      <212> PRT
      <213> Homo sapiens


      <400> 1000
 Met Ala Pro Pro Gln Pro Leu Ser Arg Ile Cys Leu Cys Asp His Thr
   1               5                  10                  15    
 Gly Leu Ser Trp Ala Arg Ala Phe Ser His Ser Ala Ala Leu Trp Thr
              20                  25                  30        
 Pro Val Gln Glu Pro Ala Ala Arg Gly Gly Tyr Leu Leu Arg Val His
          35                  40                  45            
 Ile Leu Leu Gly Val Pro Asn Ser Cys Pro Ala Ser Pro Arg Gly Ala
      50                  55                  60                
 Gly Ser Ser Ser Tyr Arg Phe Val Gln Asn Val Thr Ser Asp Leu Gln
  65                  70                  75                  80
 Leu Ala Ala Glu Phe Ala Ala Lys Ala Ala Ser Glu Gln Gln Ala Asp
                  85                  90                  95    
 Thr Ser Gly Gly Asp Ser Pro Lys Asp Glu Ser Lys Pro Pro Phe Ser
             100                 105                 110        
 Tyr Ala Gln Leu Ile Val Gln Ala Ile Ser Ser Ala Gln Asp Arg Gln
         115                 120                 125            
 Leu Thr Leu Ser Gly Ile Tyr Ala His Ile Thr Lys His Tyr Pro Tyr
     130                 135                 140                
 Tyr Arg Thr Ala Asp Lys Gly Trp Gln Asn Ser Ile Arg His Asn Leu
 145                 150                 155                 160
 Ser Leu Asn Arg Tyr Phe Ile Lys Val Pro Arg Ser Gln Glu Glu Pro
                 165                 170                 175    
 Gly Lys Gly Ser Phe Trp Arg Ile Asp Pro Ala Ser Glu Ala Lys Leu
             180                 185                 190        
 Val Glu Gln Ala Phe Arg Lys Arg Arg Gln Arg Gly Val Ser Cys Phe
         195                 200                 205            
 Arg Thr Pro Phe Gly Pro Leu Ser Ser Arg Ser Ala Pro Ala Ser Pro
     210                 215                 220                
 Thr His Pro Gly Leu Met Ser Pro Arg Ser Gly Gly Leu Gln Thr Pro
 225                 230                 235                 240
 Glu Cys Leu Ser Arg Glu Gly Ser Pro Ile Pro His Asp Pro Glu Phe
                 245                 250                 255    
 Gly Ser Lys Leu Ala Ser Val Pro Glu Tyr Arg Tyr Ser Gln Ser Ala
             260                 265                 270        
 Pro Gly Ser Pro Val Ser Ala Gln Pro Val Ile Met Ala Val Pro Pro
         275                 280                 285            
 Arg Pro Ser Ser Leu Val Ala Lys Pro Val Ala Tyr Met Pro Ala Ser
     290                 295                 300                
 Ile Val Thr Ser Gln Gln Pro Ala Gly His Ala Ile His Val Val Gln
 305                 310                 315                 320
 Gln Ala Pro Thr Val Thr Met Val Arg Val Val Thr Thr Ser Ala Asn
                 325                 330                 335    
 Ser Ala Asn Gly Tyr Ile Leu Thr Ser Gln Gly Ala Ala Gly Gly Ser
             340                 345                 350        
 His Asp Ala Ala Gly Ala Ala Val Leu Asp Leu Gly Ser Glu Ala Arg
         355                 360                 365            
 Gly Leu Glu Glu Lys Pro Thr Ile Ala Phe Ala Thr Ile Pro Ala Ala
     370                 375                 380                
 Gly Gly Val Ile Gln Thr Val Ala Ser Gln Met Ala Pro Gly Val Pro
 385                 390                 395                 400
 Gly His Thr Val Thr Ile Leu Gln Pro Ala Thr Pro Val Thr Leu Gly
                 405                 410                 415    
 Gln His His Leu Pro Val Arg Ala Val Thr Gln Asn Gly Lys His Ala
             420                 425                 430        
 Val Pro Thr Asn Ser Leu Ala Gly Asn Ala Tyr Ala Leu Thr Ser Pro
         435                 440                 445            
 Leu Gln Leu Leu Ala Thr Gln Ala Ser Ser Ser Ala Pro Val Val Val
     450                 455                 460                
 Thr Arg Val Cys Glu Val Gly Pro Lys Glu Pro Ala Ala Ala Val Ala
 465                 470                 475                 480
 Ala Thr Ala Thr Thr Thr Pro Ala Thr Ala Thr Thr Ala Ser Ala Ser
                 485                 490                 495    
 Ala Ser Ser Thr Gly Glu Pro Glu Val Lys Arg Ser Arg Val Glu Glu
             500                 505                 510        
 Pro Ser Gly Ala Val Thr Thr Pro Ala Gly Val Ile Ala Ala Ala Gly
         515                 520                 525            
 Pro Gln Gly Pro Gly Thr Gly Glu Ser Ala Val Ser Phe Ala Gly Arg
     530                 535                 540                
 Ser Gly Ala Gly Ser Pro Gly Pro Gly Pro Gln Arg Glu Thr Ala Thr
 545                 550                 555                 560
 Asp Ser Thr Gln Ser Ser Gly Ser Ala
                 565                



      <210> 1001
      <211> 244
      <212> PRT
      <213> Homo sapiens


      <400> 1001
 Met Glu Tyr Tyr Lys Arg Arg Ile Asn Ile Ser Leu Gly Thr Asn Tyr
   1               5                  10                  15    
 Gln Gly Thr Tyr Ala His Leu Ser Gly Asp Asp Ala Lys Ala Leu Ala
              20                  25                  30        
 Phe Gln Ser Phe Val Gln Ser Gln Lys Asp Val Arg Pro Arg Arg Ala
          35                  40                  45            
 Asn Ala Ser Leu Phe Gly Leu Ser Ser Leu Ile Val Lys Thr Pro Leu
      50                  55                  60                
 Thr Tyr Gly Ser Phe Leu Ala Gly Glu Glu Thr Glu Val Arg Val Gly
  65                  70                  75                  80
 His Pro Glu Leu Gly Arg Ala Val Gly Ser Leu Gln Pro Leu Arg Ser
                  85                  90                  95    
 Arg Gln Ile Phe Pro Gly Pro Gln Pro Gly Thr Leu His Thr Pro Ala
             100                 105                 110        
 His Ser Pro Ala Asn His Leu Ser Arg Thr Gln Ala Gly Gly Ala Ser
         115                 120                 125            
 Arg Pro Pro Ala Ser Pro Leu Ala His Arg Trp Gly Leu Pro Ala Arg
     130                 135                 140                
 Leu Ser Ala Ala Glu Val Gly Ala Leu Ala Gly Val Arg Ser Arg Ser
 145                 150                 155                 160
 Ser Thr Gly Ser Gly Pro Leu Gln Gln Pro Ala Trp Ser Pro Ser Met
                 165                 170                 175    
 Ala Gly Arg Gly Arg Gly Gly Gly Thr Gly Ile Ala Pro Pro Ser Leu
             180                 185                 190        
 Gly Arg Gly Arg Gly Ser Cys Ala Arg Trp Ala Cys Ala Pro Ser Ser
         195                 200                 205            
 Pro Trp Ala Leu Leu Glu Asn Pro Pro His Pro Ala Gly Pro Gly Pro
     210                 215                 220                
 Pro Ala Ala Ser Gln Ala Trp Ala Ile Cys Pro Val Ala Ser Ala Trp
 225                 230                 235                 240
 His Ser Thr Ser
                



      <210> 1002
      <211> 578
      <212> PRT
      <213> Homo sapiens


      <400> 1002
 Met Leu Arg Arg Gly His Leu Ala Phe Arg Asp Met Ala Ile Glu Phe
   1               5                  10                  15    
 Pro Gln Glu Glu Trp Lys Cys Leu Asp Pro Ala Gln Arg Thr Leu Tyr
              20                  25                  30        
 Arg Glu Val Met Val Glu Asn Tyr Arg Asn Leu Val Phe Leu Gly Ile
          35                  40                  45            
 Cys Leu Pro Asp Leu Ser Val Ile Ser Met Leu Glu Gln Arg Arg Asp
      50                  55                  60                
 Pro Arg Asn Leu Gln Ser Glu Val Lys Ile Ala Asn Asn Pro Gly Gly
  65                  70                  75                  80
 Arg Glu Cys Ile Lys Gly Val Asn Ala Glu Ser Ser Ser Lys Leu Gly
                  85                  90                  95    
 Ser Asn Ala Gly Asn Lys Ser Leu Lys Asn Gln Leu Gly Leu Thr Phe
             100                 105                 110        
 Gln Leu His Leu Ser Glu Leu Gln Leu Phe Gln Ala Glu Arg Asn Ile
         115                 120                 125            
 Ser Gly Cys Lys His Val Glu Lys Pro Ile Asn Asn Asn Ser Leu Val
     130                 135                 140                
 Ser Pro Leu Gln Lys Ile Tyr Ser Ser Val Lys Ser His Ile Leu Asn
 145                 150                 155                 160
 Lys Tyr Arg Asn Asp Phe Asp Asp Ser Pro Phe Leu Pro Gln Glu Gln
                 165                 170                 175    
 Lys Ala Gln Ile Arg Glu Lys Pro Cys Glu Cys Asn Glu His Gly Lys
             180                 185                 190        
 Ala Phe Arg Val Ser Ser Ser Leu Ala Asn His Gln Val Ile His Thr
         195                 200                 205            
 Ala Asp Asn Pro Tyr Lys Cys Asn Glu Cys Asp Lys Val Phe Ser Asn
     210                 215                 220                
 Ser Ser Asn Leu Val Gln His Gln Arg Ile His Thr Gly Glu Lys Pro
 225                 230                 235                 240
 Tyr Lys Cys His Glu Cys Gly Lys Leu Phe Asn Arg Ile Ser Leu Leu
                 245                 250                 255    
 Ala Arg His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys His
             260                 265                 270        
 Glu Cys Gly Lys Val Phe Thr Gln Asn Ser His Leu Ala Asn His His
         275                 280                 285            
 Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys
     290                 295                 300                
 Val Phe Asn Arg Asn Ala His Leu Ala Arg His Gln Lys Ile His Ser
 305                 310                 315                 320
 Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe Ser Gly
                 325                 330                 335    
 Gly Ser Gly Leu Thr Ala His Leu Val Ile His Thr Gly Glu Lys Leu
             340                 345                 350        
 Tyr Lys Cys Asn Lys Cys Gly Lys Val Phe Asn Arg Asn Ala His Leu
         355                 360                 365            
 Thr Arg His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys
     370                 375                 380                
 Glu Cys Gly Lys Val Phe Arg His Lys Phe Cys Leu Thr Asn His His
 385                 390                 395                 400
 Arg Met His Thr Gly Glu Gln Pro Tyr Lys Cys Asn Glu Cys Gly Lys
                 405                 410                 415    
 Ala Phe Arg Asp Cys Ser Gly Leu Thr Ala His Leu Leu Ile His Thr
             420                 425                 430        
 Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Ala Lys Val Phe Arg His
         435                 440                 445            
 Arg Leu Ser Leu Ser Asn His Gln Arg Phe His Thr Gly Glu Lys Pro
     450                 455                 460                
 Tyr Arg Cys Asp Glu Cys Gly Lys Asp Phe Thr Arg Asn Ser Asn Leu
 465                 470                 475                 480
 Ala Asn His His Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Ser
                 485                 490                 495    
 Glu Cys His Lys Val Phe Ser His Asn Ser His Leu Ala Arg His Arg
             500                 505                 510        
 Gln Ile His Thr Gly Glu Lys Ser Tyr Lys Cys Asn Glu Cys Gly Lys
         515                 520                 525            
 Val Phe Ser His Lys Leu Tyr Leu Lys Lys His Glu Arg Ile His Thr
     530                 535                 540                
 Gly Glu Lys Pro Tyr Arg Cys His Glu Cys Gly Lys Asp Phe Thr Arg
 545                 550                 555                 560
 Asn Ser Asn Leu Ala Asn His His Arg Ile His Thr Gly Glu Lys Pro
                 565                 570                 575    
 Tyr Arg
        



      <210> 1003
      <211> 631
      <212> PRT
      <213> Homo sapiens


      <400> 1003
 Met Ser His Gln Glu Gly Ser Thr Asp Gly Leu Pro Asp Leu Gly Thr
   1               5                  10                  15    
 Glu Ser Leu Phe Ser Ser Pro Glu Glu Gln Ser Gly Ala Val Ala Ala
              20                  25                  30        
 Thr Glu Ala Ser Ser Asp Ile Asp Ile Ala Thr Ser Glu Leu Ser Val
          35                  40                  45            
 Thr Val Thr Gly Asp Gly Ser Asp Ser Arg Asp Gly Gly Phe Pro Asn
      50                  55                  60                
 Asp Ala Ser Thr Glu Asn Arg Ser Ser Asp Gln Glu Ser Ala Ser Glu
  65                  70                  75                  80
 Asp Ile Glu Leu Glu Ser Leu Glu Asp Phe Glu His Phe Leu Met Ser
                  85                  90                  95    
 Gly Glu Ser Leu Phe His Tyr Pro Leu Val Gly Glu Glu Glu Thr Glu
             100                 105                 110        
 Arg Glu Glu Glu Asp Glu Glu Ile Gln Glu Glu Gly Gly Glu Glu Glu
         115                 120                 125            
 Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
     130                 135                 140                
 Glu Glu Glu Gln Pro Arg Ala Gly Pro Gln Gly Ser Gly Gly Asn His
 145                 150                 155                 160
 Glu Gln Tyr Ser Leu Glu Glu Asp Gln Ala Leu Glu Glu Trp Val Ser
                 165                 170                 175    
 Ser Glu Thr Ser Ala Leu Pro Arg Pro Arg Trp Gln Val Val Thr Ala
             180                 185                 190        
 Leu His Gln Arg Gln Leu Gly Ser Arg Pro Arg Phe Val Tyr Glu Ala
         195                 200                 205            
 Cys Gly Ala Arg Ala Phe Val Gln Arg Phe Arg Leu Gln Tyr Arg Leu
     210                 215                 220                
 Ala Asp His Val Gly Cys Val Asn Thr Val His Phe Asn Gln Arg Gly
 225                 230                 235                 240
 Thr Arg Leu Ala Ser Ser Gly Asp Asp Leu Lys Val Ile Val Trp Asp
                 245                 250                 255    
 Trp Val Arg Gln Arg Pro Val Leu Asn Phe Glu Ser Gly His Thr Asn
             260                 265                 270        
 Asn Val Phe Gln Ala Lys Phe Leu Pro Asn Cys Gly Asp Ser Thr Leu
         275                 280                 285            
 Ala Met Cys Ala Arg Asp Gly Gln Val Arg Val Ala Glu Leu Ile Asn
     290                 295                 300                
 Ala Ser Tyr Phe Asn Asn Thr Lys Cys Val Ala Gln His Arg Gly Pro
 305                 310                 315                 320
 Ala His Lys Leu Ala Leu Glu Pro Asp Ser Pro Tyr Lys Phe Leu Thr
                 325                 330                 335    
 Ser Gly Glu Asp Ala Val Val Phe Thr Ile Asp Leu Arg Gln Asp Arg
             340                 345                 350        
 Pro Ala Ser Lys Val Val Val Thr Arg Glu Asn Asp Lys Lys Val Gly
         355                 360                 365            
 Leu Tyr Thr Ile Thr Val Asn Pro Ala Asn Thr Tyr Gln Phe Ala Val
     370                 375                 380                
 Gly Gly Gln Asp Gln Phe Val Arg Ile Tyr Asp Gln Arg Lys Ile Asp
 385                 390                 395                 400
 Lys Lys Glu Asn Asn Gly Val Leu Lys Lys Phe Thr Pro His His Leu
                 405                 410                 415    
 Val Asn Cys Asp Phe Pro Thr Asn Ile Thr Cys Val Val Tyr Ser His
             420                 425                 430        
 Asp Gly Thr Glu Leu Leu Ala Ser Tyr Asn Asp Asp Asp Ile Tyr Leu
         435                 440                 445            
 Phe Asn Ser Ser His Ser Asp Gly Ala Gln Tyr Ser Lys Arg Phe Lys
     450                 455                 460                
 Gly His Arg Asn Asn Thr Thr Val Lys Gly Val Asn Phe Tyr Gly Pro
 465                 470                 475                 480
 Arg Ser Glu Phe Val Val Ser Gly Ser Asp Cys Gly His Ile Phe Phe
                 485                 490                 495    
 Trp Glu Lys Ser Ser Cys Gln Ile Ile Gln Phe Leu Lys Gly Ser Arg
             500                 505                 510        
 Glu Gly Thr Ile Asn Cys Leu Glu Pro His Pro Tyr Leu Pro Val Leu
         515                 520                 525            
 Ala Cys Ser Gly Leu Asp His Asp Val Lys Ile Trp Thr Pro Thr Ala
     530                 535                 540                
 Lys Ala Ala Thr Glu Leu Thr Gly Leu Lys Lys Val Ile Lys Lys Asn
 545                 550                 555                 560
 Lys Trp Glu Arg Asp Glu Asp Ser Leu His His Gly Ser Leu Phe Asp
                 565                 570                 575    
 Gln Tyr Met Leu Trp Phe Leu Leu Arg His Val Thr Gln Arg Gly Arg
             580                 585                 590        
 His Gln Asp Trp Arg Ser Gly Glu Ala Glu Phe Pro Asp Glu Glu Ser
         595                 600                 605            
 Asp Glu Ser Ser Ser Thr Ser Glu Thr Ser Glu Glu Glu Val Gln Asp
     610                 615                 620                
 Arg Val Gln Cys Met Pro Ser
 625                 630    



      <210> 1004
      <211> 1426
      <212> PRT
      <213> Homo sapiens


      <400> 1004
 Met His Ser Ser Asn Pro Lys Val Arg Ser Ser Pro Ser Gly Asn Thr
   1               5                  10                  15    
 Gln Ser Ser Pro Lys Ser Lys Gln Glu Val Met Val Arg Pro Pro Thr
              20                  25                  30        
 Val Met Ser Pro Ser Gly Asn Pro Gln Leu Asp Ser Lys Phe Ser Asn
          35                  40                  45            
 Gln Gly Lys Gln Gly Gly Ser Ala Ser Gln Ser Gln Pro Ser Pro Cys
      50                  55                  60                
 Asp Ser Lys Ser Gly Gly His Thr Pro Lys Ala Leu Pro Gly Pro Gly
  65                  70                  75                  80
 Gly Ser Met Gly Leu Lys Asn Gly Ala Gly Asn Gly Ala Lys Gly Lys
                  85                  90                  95    
 Gly Lys Arg Glu Arg Ser Ile Ser Ala Asp Ser Phe Asp Gln Arg Asp
             100                 105                 110        
 Pro Gly Thr Pro Asn Asp Asp Ser Asp Ile Lys Glu Cys Asn Ser Ala
         115                 120                 125            
 Asp His Ile Lys Ser Gln Asp Ser Gln His Thr Pro His Ser Met Thr
     130                 135                 140                
 Pro Ser Asn Ala Thr Ala Pro Arg Ser Ser Thr Pro Ser His Gly Gln
 145                 150                 155                 160
 Thr Thr Ala Thr Glu Pro Thr Pro Ala Gln Lys Thr Pro Ala Lys Val
                 165                 170                 175    
 Val Tyr Val Phe Ser Thr Glu Met Ala Asn Lys Ala Ala Glu Ala Val
             180                 185                 190        
 Leu Lys Gly Gln Val Glu Thr Ile Val Ser Phe His Ile Gln Asn Ile
         195                 200                 205            
 Ser Asn Asn Lys Thr Glu Arg Ser Thr Ala Pro Leu Asn Thr Gln Ile
     210                 215                 220                
 Ser Ala Leu Arg Asn Asp Pro Lys Pro Leu Pro Gln Gln Pro Pro Ala
 225                 230                 235                 240
 Pro Ala Asn Gln Asp Gln Asn Ser Ser Gln Asn Thr Arg Leu Gln Pro
                 245                 250                 255    
 Thr Pro Pro Ile Pro Ala Pro Ala Pro Lys Pro Ala Ala Pro Pro Arg
             260                 265                 270        
 Pro Leu Asp Arg Glu Ser Pro Gly Val Glu Asn Lys Leu Ile Pro Ser
         275                 280                 285            
 Val Gly Ser Pro Ala Ser Ser Thr Pro Leu Pro Pro Asp Gly Thr Gly
     290                 295                 300                
 Pro Asn Ser Thr Pro Asn Asn Arg Ala Val Thr Pro Val Ser Gln Gly
 305                 310                 315                 320
 Ser Asn Ser Ser Ser Ala Asp Pro Lys Ala Pro Pro Pro Pro Pro Val
                 325                 330                 335    
 Ser Ser Gly Glu Pro Pro Thr Leu Gly Glu Asn Pro Asp Gly Leu Ser
             340                 345                 350        
 Gln Glu Gln Leu Glu His Arg Glu Arg Ser Leu Gln Thr Leu Arg Asp
         355                 360                 365            
 Ile Gln Arg Met Leu Phe Pro Asp Glu Lys Glu Phe Thr Gly Ala Gln
     370                 375                 380                
 Ser Gly Gly Pro Gln Gln Asn Pro Gly Val Leu Asp Gly Pro Gln Lys
 385                 390                 395                 400
 Lys Pro Glu Gly Pro Ile Gln Ala Met Met Ala Gln Ser Gln Ser Leu
                 405                 410                 415    
 Gly Lys Gly Pro Gly Pro Arg Thr Asp Val Gly Ala Pro Phe Gly Pro
             420                 425                 430        
 Gln Gly His Arg Asp Val Pro Phe Ser Pro Asp Glu Met Val Pro Pro
         435                 440                 445            
 Ser Met Asn Ser Gln Ser Gly Thr Ile Gly Pro Asp His Leu Asp His
     450                 455                 460                
 Met Thr Pro Glu Gln Ile Ala Trp Leu Lys Leu Gln Gln Glu Phe Tyr
 465                 470                 475                 480
 Glu Glu Lys Arg Arg Lys Pro Glu Gln Val Val Val Gln Gln Cys Ser
                 485                 490                 495    
 Leu Gln Asp Met Met Val His Gln His Gly Pro Arg Gly Val Val Arg
             500                 505                 510        
 Gly Pro Pro Pro Pro Tyr Gln Met Thr Pro Ser Glu Gly Trp Ala Pro
         515                 520                 525            
 Gly Gly Thr Glu Pro Phe Ser Asp Gly Ile Asn Met Pro His Ser Leu
     530                 535                 540                
 Pro Pro Arg Gly Met Ala Pro His Pro Asn Met Pro Gly Ser Gln Met
 545                 550                 555                 560
 Arg Leu Pro Gly Phe Ala Gly Met Ile Asn Ser Glu Met Glu Gly Pro
                 565                 570                 575    
 Asn Val Pro Asn Pro Ala Ser Arg Pro Gly Leu Ser Gly Val Ser Trp
             580                 585                 590        
 Pro Asp Asp Val Pro Lys Ile Pro Asp Gly Arg Asn Phe Pro Pro Gly
         595                 600                 605            
 Gln Gly Ile Phe Ser Gly Pro Gly Arg Gly Glu Arg Phe Pro Asn Pro
     610                 615                 620                
 Gln Gly Leu Ser Glu Glu Met Phe Gln Gln Gln Leu Ala Glu Lys Gln
 625                 630                 635                 640
 Leu Gly Leu Pro Pro Gly Met Ala Met Glu Gly Ile Arg Pro Ser Met
                 645                 650                 655    
 Glu Met Asn Arg Met Ile Pro Gly Ser Gln Arg His Met Glu Pro Gly
             660                 665                 670        
 Asn Asn Pro Ile Phe Pro Arg Ile Pro Val Glu Gly Pro Leu Ser Pro
         675                 680                 685            
 Ser Arg Gly Asp Phe Pro Lys Gly Ile Pro Pro Gln Met Gly Pro Gly
     690                 695                 700                
 Arg Glu Leu Glu Phe Gly Met Val Pro Ser Gly Met Lys Gly Asp Val
 705                 710                 715                 720
 Asn Leu Asn Val Asn Met Gly Ser Asn Ser Gln Met Ile Pro Gln Lys
                 725                 730                 735    
 Met Arg Glu Ala Gly Ala Gly Pro Glu Glu Met Leu Lys Leu Arg Pro
             740                 745                 750        
 Gly Gly Ser Asp Met Leu Pro Ala Gln Gln Lys Met Val Pro Leu Pro
         755                 760                 765            
 Phe Gly Glu His Pro Gln Gln Glu Tyr Gly Met Gly Pro Arg Pro Phe
     770                 775                 780                
 Leu Pro Met Ser Gln Gly Pro Gly Ser Asn Ser Gly Leu Arg Asn Leu
 785                 790                 795                 800
 Arg Glu Pro Ile Gly Pro Asp Gln Arg Thr Asn Ser Arg Leu Ser His
                 805                 810                 815    
 Met Pro Pro Leu Pro Leu Asn Pro Ser Ser Asn Pro Thr Ser Leu Asn
             820                 825                 830        
 Thr Ala Pro Pro Val Gln Arg Gly Leu Gly Arg Lys Pro Leu Asp Ile
         835                 840                 845            
 Ser Val Ala Gly Ser Gln Val His Ser Pro Gly Ile Asn Pro Leu Lys
     850                 855                 860                
 Ser Pro Thr Met His Gln Val Gln Ser Pro Met Leu Gly Ser Pro Ser
 865                 870                 875                 880
 Gly Asn Leu Lys Ser Pro Gln Thr Pro Ser Gln Leu Ala Gly Met Leu
                 885                 890                 895    
 Ala Gly Pro Ala Ala Ala Ala Ser Ile Lys Ser Pro Pro Val Leu Gly
             900                 905                 910        
 Ser Ala Ala Ala Ser Pro Val His Leu Lys Ser Pro Ser Leu Pro Ala
         915                 920                 925            
 Pro Ser Pro Gly Trp Thr Ser Ser Pro Lys Pro Pro Leu Gln Ser Pro
     930                 935                 940                
 Gly Ile Pro Pro Asn His Lys Ala Pro Leu Thr Met Ala Ser Pro Ala
 945                 950                 955                 960
 Met Leu Gly Asn Val Glu Ser Gly Gly Pro Pro Pro Pro Thr Ala Ser
                 965                 970                 975    
 Gln Pro Ala Ser Val Asn Ile Pro Gly Ser Leu Pro Ser Ser Thr Pro
             980                 985                 990        
 Tyr Thr Met Pro Pro Glu Pro Thr Leu Ser Gln Asn Pro Leu Ser Ile
         995                1000                1005            
 Met Met Ser Arg Met Ser Lys Phe Ala Met Pro Ser Ser Thr Pro Leu
    1010                1015                1020                
 Tyr His Asp Ala Ile Lys Thr Val Ala Ser Ser Asp Asp Asp Ser Pro
1025                1030                1035                1040
 Pro Ala Arg Ser Pro Asn Leu Pro Ser Met Asn Asn Met Pro Gly Met
                1045                1050                1055    
 Gly Ile Asn Thr Gln Asn Pro Arg Ile Ser Gly Pro Asn Pro Val Val
            1060                1065                1070        
 Pro Met Pro Thr Leu Ser Pro Met Glu Met Thr Gln Pro Leu Ser His
        1075                1080                1085            
 Ser Asn Gln Met Pro Ser Pro Asn Ala Val Gly Pro Asn Ile Pro Pro
    1090                1095                1100                
 His Gly Val Pro Met Gly Pro Gly Leu Met Ser His Asn Pro Ile Met
1105                1110                1115                1120
 Gly His Gly Ser Gln Glu Pro Pro Met Val Pro Gln Gly Arg Met Gly
                1125                1130                1135    
 Phe Pro Gln Gly Phe Pro Pro Val Gln Ser Pro Pro Gln Gln Val Pro
            1140                1145                1150        
 Phe Pro His Asn Gly Pro Ser Gly Gly Gln Gly Ser Phe Pro Gly Gly
        1155                1160                1165            
 Met Gly Phe Pro Gly Glu Gly Pro Leu Gly Arg Pro Ser Asn Leu Pro
    1170                1175                1180                
 Gln Ser Ser Ala Asp Ala Ala Leu Cys Lys Pro Gly Gly Pro Gly Gly
1185                1190                1195                1200
 Pro Asp Ser Phe Thr Val Leu Gly Asn Ser Met Pro Ser Val Phe Thr
                1205                1210                1215    
 Asp Pro Asp Leu Gln Glu Val Ile Arg Pro Gly Ala Thr Gly Ile Pro
            1220                1225                1230        
 Glu Phe Asp Leu Ser Arg Ile Ile Pro Ser Glu Lys Pro Ser Gln Thr
        1235                1240                1245            
 Leu Gln Tyr Phe Pro Arg Gly Glu Val Pro Gly Arg Lys Gln Pro Gln
    1250                1255                1260                
 Gly Pro Gly Pro Gly Phe Ser His Met Gln Gly Met Met Gly Glu Gln
1265                1270                1275                1280
 Ala Pro Arg Met Gly Leu Ala Leu Pro Gly Met Gly Gly Pro Gly Pro
                1285                1290                1295    
 Val Gly Thr Pro Asp Ile Pro Leu Gly Thr Ala Pro Ser Met Pro Gly
            1300                1305                1310        
 His Asn Pro Met Arg Pro Pro Ala Phe Leu Gln Gln Gly Met Met Gly
        1315                1320                1325            
 Pro His His Arg Met Met Ser Pro Ala Gln Ser Thr Met Pro Gly Gln
    1330                1335                1340                
 Pro Thr Leu Met Ser Asn Pro Ala Ala Ala Val Gly Met Ile Pro Gly
1345                1350                1355                1360
 Lys Asp Arg Gly Pro Ala Gly Leu Tyr Thr His Pro Gly Pro Val Gly
                1365                1370                1375    
 Ser Pro Gly Met Met Met Ser Met Gln Gly Met Met Gly Pro Gln Gln
            1380                1385                1390        
 Asn Ile Met Ile Pro Pro Gln Met Arg Pro Arg Gly Met Ala Ala Asp
        1395                1400                1405            
 Val Gly Met Gly Gly Phe Ser Gln Gly Pro Gly Asn Pro Gly Asn Met
    1410                1415                1420                
 Met Phe
1425    



      <210> 1005
      <211> 202
      <212> PRT
      <213> Homo sapiens


      <400> 1005
 Met Asn Gly Gln Asn Phe Arg Ala Ala Phe Thr Glu Leu Val Met Phe
   1               5                  10                  15    
 Glu Leu Gly Ile Arg Leu Lys Arg Asn Leu Gln Cys Arg Ser Arg Lys
              20                  25                  30        
 Glu Glu Leu Asp Ile Gln Ala Arg Val Ala Ala Gly Ala Arg Thr Gln
          35                  40                  45            
 Asn Arg Glu Ser Val Thr Phe Glu Asp Val Ala Val Tyr Phe Ser Glu
      50                  55                  60                
 Asn Glu Trp Ile Gly Leu Gly Pro Ala Gln Arg Ala Leu Tyr Arg Asp
  65                  70                  75                  80
 Val Met Leu Glu Asn Tyr Gly Ala Val Ala Ser Leu Ala Ala Phe Pro
                  85                  90                  95    
 Phe Pro Lys Pro Ala Leu Ile Ser Gln Leu Glu Arg Gly Glu Thr Pro
             100                 105                 110        
 Trp Cys Ser Val Pro Arg Gly Ala Leu Asp Gly Glu Ala Pro Arg Gly
         115                 120                 125            
 Ile Ser Ser Val Glu Lys Ser Trp Ala Pro Ser Leu Phe Pro Gly Thr
     130                 135                 140                
 Arg Tyr Asp Ile Glu Phe His Asp Tyr Ala Cys Thr Leu Gly Tyr Asn
 145                 150                 155                 160
 Pro Pro Gly Gly Arg Thr Ser Ile Val Ser Phe Phe Val Leu Pro Thr
                 165                 170                 175    
 Glu Pro Val Gly Asp Leu His Thr Gly Ala Leu Gln Ser Val Leu Ile
             180                 185                 190        
 Glu Leu Leu Lys Ala Ala Ser Leu Gln Ser
         195                 200        



      <210> 1006
      <211> 120
      <212> PRT
      <213> Homo sapiens


      <400> 1006
 Met Gly Leu His Ser Pro Cys Ala Phe Leu Pro Gln Glu Arg Asp Ala
   1               5                  10                  15    
 Gly Val Leu Ser Arg Val Cys Gly Leu Leu Arg Gln Leu His Thr Ala
              20                  25                  30        
 Tyr Ser Gly Leu Val Ser Ser Leu Gln Gly Leu Pro Ala Glu Leu Gln
          35                  40                  45            
 Gln Pro Val Gly Arg Ala Arg His Ser Leu Cys Glu Leu Tyr Gly Ile
      50                  55                  60                
 Val Ala Ser Ala Gly Ser Val Glu Glu Leu Pro Ala Glu Arg Leu Val
  65                  70                  75                  80
 Gln Ser Arg Glu Gly Val His Gln Ala Trp Gln Gly Leu Glu Gln Leu
                  85                  90                  95    
 Leu Glu Gly Leu Gln His Asn Pro Pro Leu Ser Trp Leu Val Gly Pro
             100                 105                 110        
 Phe Ala Leu Pro Ala Gly Gly Gln
         115                 120



      <210> 1007
      <211> 87
      <212> PRT
      <213> Homo sapiens


      <400> 1007
 Met Glu Lys Glu Val Ala Gln Ser Leu Leu Asn Ala Lys Glu Gln Leu
   1               5                  10                  15    
 Thr Arg Glu Leu Glu Glu Leu Lys Glu Ile Glu Ala Asp Leu Glu Arg
              20                  25                  30        
 Gln Glu Lys Glu Val Asp Glu Asp Thr Thr Val Thr Ile Pro Ser Ala
          35                  40                  45            
 Val Tyr Val Ala Gln Leu Tyr His Gln Val Ser Lys Ile Glu Trp Asp
      50                  55                  60                
 Tyr Glu Cys Glu Pro Gly Met Val Lys Gly Arg Gly Met Phe Glu Cys
  65                  70                  75                  80
 His Gly Val Pro Arg Leu Cys
                  85        



      <210> 1008
      <211> 591
      <212> PRT
      <213> Homo sapiens


      <400> 1008
 Met Gly Glu Ser Gly Ser Ala Gln Asn Tyr Arg Arg Phe Arg Glu Thr
   1               5                  10                  15    
 Val Ala Gln Pro Arg Gly Gly Arg Arg Phe Met Asp Ser Lys Arg Lys
              20                  25                  30        
 Ala Arg Glu Ser Lys Ser Gln Gly Ser Ser Leu Pro Val Pro Val Leu
          35                  40                  45            
 Gln Arg Arg Lys Val Met Glu Leu Gly Cys Val Gly Gly Asn Asn Pro
      50                  55                  60                
 Asp Glu Glu Lys Asn Ser Thr Ala Asn Ser Gly Val Ser Ser Thr Asp
  65                  70                  75                  80
 Ile Leu Ser Phe Gly Tyr Gln Gly Ser Leu Leu Ser His Thr Gln Asp
                  85                  90                  95    
 Gln Asp Arg Asn Thr Glu Glu Leu Asp Met Ala Gly Val Gln Ser Leu
             100                 105                 110        
 Val Pro Arg Leu Arg His Gln Leu Ser Phe Leu Pro Leu Lys Gly Ala
         115                 120                 125            
 Gly Ser Ser Cys Pro Pro Ser Pro Pro Glu Ile Ser Ala Gly Glu Ile
     130                 135                 140                
 Tyr Phe Val Glu Leu Val Lys Glu Asp Gly Thr Leu Gly Phe Ser Val
 145                 150                 155                 160
 Thr Gly Cys Asn Leu Ala Thr Ser Ile Ile Met Lys Asn Ala His Ile
                 165                 170                 175    
 Leu Trp Pro Ile Lys Ala His Lys Thr Cys Gln Ala Gln Ala Phe Arg
             180                 185                 190        
 Pro Ile Ala Ile Ser Thr Tyr Ala Gly His Tyr Leu Tyr Arg Asp Ser
         195                 200                 205            
 Gly Ala Ser His Gly Gly Ile Asn Thr Ser Val Pro Tyr Gly Gly Ile
     210                 215                 220                
 Tyr Val Lys Ser Ile Val Pro Gly Arg Pro Ala Ala Lys Glu Gly Gln
 225                 230                 235                 240
 Ile Leu Gln Gly Asp Arg Leu Leu Gln Val Asp Gly Val Ile Leu Cys
                 245                 250                 255    
 Gly Leu Thr His Lys Gln Ala Val Gln Cys Leu Lys Gly Pro Gly Gln
             260                 265                 270        
 Val Ala Arg Leu Val Leu Glu Arg Arg Val Pro Arg Ser Thr Gln Gln
         275                 280                 285            
 Cys Pro Ser Ala Asn Asp Ser Met Gly Asp Glu Arg Thr Ala Val Ser
     290                 295                 300                
 Leu Val Thr Ala Leu Pro Gly Arg Pro Ser Ser Cys Val Ser Val Thr
 305                 310                 315                 320
 Asp Gly Pro Lys Phe Glu Val Lys Leu Lys Lys Asn Ala Asn Gly Leu
                 325                 330                 335    
 Gly Phe Ser Phe Val Gln Met Glu Lys Glu Ser Cys Ser His Leu Lys
             340                 345                 350        
 Ser Asp Leu Val Arg Ile Lys Arg Leu Phe Pro Gly Gln Pro Ala Glu
         355                 360                 365            
 Glu Asn Gly Ala Ile Ala Ala Gly Asp Ile Ile Leu Ala Val Asn Gly
     370                 375                 380                
 Arg Ser Thr Glu Gly Leu Ile Phe Gln Glu Val Leu His Leu Leu Arg
 385                 390                 395                 400
 Gly Ala Pro Gln Glu Val Thr Leu Leu Leu Cys Arg Pro Pro Pro Gly
                 405                 410                 415    
 Ala Leu Pro Glu Met Glu Gln Glu Trp Gln Thr Pro Glu Leu Ser Ala
             420                 425                 430        
 Asp Lys Glu Phe Thr Arg Ala Thr Cys Thr Asp Ser Cys Thr Ser Pro
         435                 440                 445            
 Ile Leu Asp Gln Glu Asp Ser Trp Arg Asp Ser Ala Ser Pro Asp Ala
     450                 455                 460                
 Gly Glu Gly Leu Gly Leu Arg Pro Glu Ser Ser Gln Lys Ala Ile Arg
 465                 470                 475                 480
 Glu Ala Gln Trp Gly Gln Asn Arg Glu Arg Pro Trp Ala Ser Ser Leu
                 485                 490                 495    
 Thr His Ser Pro Glu Ser His Pro His Leu Cys Lys Leu His Gln Glu
             500                 505                 510        
 Arg Asp Glu Ser Thr Leu Ala Thr Ser Leu Glu Lys Asp Val Arg Gln
         515                 520                 525            
 Asn Cys Tyr Ser Val Cys Asp Ile Met Arg Leu Gly Ser Glu Ala Gln
     530                 535                 540                
 Phe Gly Thr Asp Ala Ser Gly Ser Thr Gly Glu Glu Asp Val Leu Ser
 545                 550                 555                 560
 Gly Tyr Leu Arg Val Cys Ser Tyr Trp Gly Ala Pro Glu Pro Ile Leu
                 565                 570                 575    
 Arg Glu Arg Gly Asn Ala Gly Lys Glu Lys Glu Ser Ser Ser Thr
             580                 585                 590    



      <210> 1009
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 1009
 Met Thr Leu Thr Lys Gly Ser Phe Thr Tyr Ser Ser Gly Glu Glu Tyr
   1               5                  10                  15    
 Arg Gly Glu Trp Lys Glu Gly Arg Arg His Gly Phe Gly Gln Leu Met
              20                  25                  30        
 Phe Ala Asp Gly Gly Thr Tyr Leu Gly His Phe Glu Asn Gly Leu Phe
          35                  40                  45            
 Asn Gly Phe Gly Val Leu Thr Phe Ser Asp Gly Ser Arg Tyr Glu Gly
      50                  55                  60                
 Glu Phe Ala Gln Gly Lys Phe Asn Gly Val Gly Val Phe Ile Arg Tyr
  65                  70                  75                  80
 Asp Asn Met Thr Phe Glu Gly Glu Phe Lys Asn Gly Arg Val Asp Gly
                  85                  90                  95    
 Phe Gly Leu Leu Thr Phe Pro Asp Gly Ser His Gly Ile Pro Arg Asn
             100                 105                 110        
 Glu Gly Leu Phe Glu Asn Asn Lys Leu Leu Arg Arg Glu Lys Cys Ser
         115                 120                 125            
 Ala Ile Val Gln Arg Ala Gln Ser Ala Ser Lys Ser Ala Arg Asn Leu
     130                 135                 140                
 Thr Ala
 145    



      <210> 1010
      <211> 244
      <212> PRT
      <213> Homo sapiens


      <400> 1010
 Met His Ala Ala Arg His Gly Trp Asp Val Glu Lys Asp Ala Pro Leu
   1               5                  10                  15    
 Phe Arg Asn Trp Ala Ile His Thr Gly Lys His Gln Pro Gly Val Asp
              20                  25                  30        
 Lys Pro Asp Pro Lys Thr Trp Lys Ala Asn Phe Arg Cys Ala Met Asn
          35                  40                  45            
 Ser Leu Pro Asp Ile Glu Glu Val Lys Asp Lys Ser Ile Lys Lys Gly
      50                  55                  60                
 Asn Asn Ala Phe Arg Val Tyr Arg Met Leu Pro Leu Ser Glu Arg Pro
  65                  70                  75                  80
 Ser Lys Lys Gly Lys Lys Pro Lys Thr Glu Lys Glu Asp Lys Val Lys
                  85                  90                  95    
 His Ile Lys Gln Glu Pro Val Glu Ser Ser Leu Gly Leu Ser Asn Gly
             100                 105                 110        
 Val Ser Asp Leu Ser Pro Glu Tyr Ala Val Leu Thr Ser Thr Ile Lys
         115                 120                 125            
 Asn Glu Val Asp Ser Thr Val Asn Ile Ile Val Val Gly Gln Ser His
     130                 135                 140                
 Leu Asp Ser Asn Ile Glu Asn Gln Glu Ile Val Thr Asn Pro Pro Asp
 145                 150                 155                 160
 Ile Cys Gln Val Val Glu Val Thr Thr Glu Ser Asp Glu Gln Pro Val
                 165                 170                 175    
 Thr Ser Asn Lys Pro Asp Leu Gln Val Thr Ile Lys Glu Glu Ser Asn
             180                 185                 190        
 Pro Val Pro Tyr Asn Ser Ser Trp Pro Pro Phe Gln Asp Leu Pro Leu
         195                 200                 205            
 Ser Ser Ser Met Thr Pro Ala Ser Ser Ser Ser Arg Pro Asp Arg Glu
     210                 215                 220                
 Thr Arg Ala Ser Val Ile Lys Lys Thr Ser Asp Ile Thr Gln Ala Arg
 225                 230                 235                 240
 Val Lys Ser Cys
                



      <210> 1011
      <211> 166
      <212> PRT
      <213> Homo sapiens


      <400> 1011
 Met Gly Arg Cys His Leu Gly Leu Leu Leu Ser Arg Tyr Met Asp Ala
   1               5                  10                  15    
 Thr Val Ser Gly Ser His Arg Arg Leu Thr Phe Asp Arg Lys Arg Met
              20                  25                  30        
 Val Cys Lys Phe Gln Glu His Arg Val Gly Phe Gln Gly Gln Asp Lys
          35                  40                  45            
 Lys Gln Gly Thr Gln Lys Ser Lys Arg Asp Arg Thr Leu Gln Pro Arg
      50                  55                  60                
 Tyr Val Pro Asp Pro Gln Arg Asp Arg Pro Phe Pro Ala Ala Ala Phe
  65                  70                  75                  80
 Ser Ser His Gln Pro Ser Ser Asn Thr Pro Ile Lys Met Leu Pro Val
                  85                  90                  95    
 Arg Ser Lys Ser Leu Ala His Gly Cys Ser Glu Ser Arg Ala Phe Val
             100                 105                 110        
 Gly Ala Leu Leu Lys Thr Ser Cys Lys Gln Gln Glu Phe Tyr Cys Met
         115                 120                 125            
 Asp Val His Ser Thr Asn Pro His Lys Gln Gly Arg Thr Ser Gln Gly
     130                 135                 140                
 Cys Lys Met Lys Leu Lys Leu Leu Pro Ala Leu Leu Leu Ser Gln Val
 145                 150                 155                 160
 Ala Gly Pro Met Leu Asp
                 165    



      <210> 1012
      <211> 852
      <212> PRT
      <213> Homo sapiens


      <400> 1012
 Met Tyr Val Ile Phe Met Ser Leu Thr Gly Thr Gly Pro Asp Gly Arg
   1               5                  10                  15    
 Ile Thr Lys Lys Asp Ile Asp Ser Phe Val Pro Ser Lys Val Ala Pro
              20                  25                  30        
 Ala Pro Ala Ala Val Val Pro Pro Thr Gly Pro Gly Met Ala Pro Val
          35                  40                  45            
 Pro Thr Gly Val Phe Thr Asp Ile Pro Ile Ser Asn Ile Arg Arg Val
      50                  55                  60                
 Ile Ala Gln Arg Leu Met Gln Ser Lys Gln Thr Ile Pro His Tyr Tyr
  65                  70                  75                  80
 Leu Ser Ile Asp Val Asn Met Gly Glu Val Leu Leu Val Arg Lys Glu
                  85                  90                  95    
 Leu Asn Lys Asp Ala Leu Gln Gln Arg Leu Thr Gln Gln Asp Thr Ser
             100                 105                 110        
 Val Leu Gln Leu Lys Gln Glu Leu Leu Arg Ala Asn Met Asp Lys Asp
         115                 120                 125            
 Glu Leu His Asn Gln Asn Val Asp Leu Gln Arg Lys Leu Asp Glu Arg
     130                 135                 140                
 Asn Arg Leu Leu Gly Glu Tyr Lys Lys Glu Leu Gly Gln Lys Asp Arg
 145                 150                 155                 160
 Leu Leu Gln Gln His Gln Ala Lys Leu Glu Glu Ala Leu Arg Lys Leu
                 165                 170                 175    
 Ser Asp Val Ser Tyr His Gln Asn Arg His His Leu Pro Ser His Ile
             180                 185                 190        
 Gly Gly Tyr Thr Val Asp Leu Glu Gln Gln Glu Ser Gln Leu Cys Arg
         195                 200                 205            
 Ser Thr Tyr Pro Gln Ile Phe Phe His Leu Cys His Leu Pro Asp Arg
     210                 215                 220                
 Gln Ala Asp Leu Ser Pro Gly Leu Arg Pro Glu Ala Glu Pro Gly Arg
 225                 230                 235                 240
 Asn Ser Asp Ser Pro Val Asp Leu Gly Ile Pro Arg Ser Arg Ser Ser
                 245                 250                 255    
 Arg Thr Asn Pro Gly Val Pro Arg Thr Gln Leu Asp Val Val Pro Arg
             260                 265                 270        
 Leu Val Thr Leu Val Thr Gly Val Ala Val Cys Gln Gly Thr Glu Arg
         275                 280                 285            
 Arg Asp Asp Leu Ala Gln Ser Asp Pro Glu Gly Tyr Glu Lys Phe Ile
     290                 295                 300                
 Gln Gln Gln Leu Lys Glu Gly Lys Gln Leu Cys Ala Ala Pro Glu Pro
 305                 310                 315                 320
 Gln Leu Cys Leu Gln Thr Arg Ile Leu Lys Pro Lys Glu Lys Ile Leu
                 325                 330                 335    
 Phe Ile Asn Leu Cys Gln Trp Thr Arg Ile Pro Ala Pro Gln Ser Thr
             340                 345                 350        
 Thr His Pro Val Pro Leu Thr Val Gly Lys Pro Glu Asp Thr Thr Glu
         355                 360                 365            
 Ile Ser Asp Ala Tyr Thr Val Ile Asp Val Ala Tyr Asn Pro Asp Val
     370                 375                 380                
 Leu His Ala Ala Glu Lys Asp Gln Val Lys Lys Asn Gln Leu Ile Gln
 385                 390                 395                 400
 Met Ala Met Lys Cys Ile Glu Glu Lys Phe Gln Phe Thr Leu Ser His
                 405                 410                 415    
 Ser Tyr His Ile Thr Lys Phe Arg Ile Lys Gly Ser Ile Gln Arg Met
             420                 425                 430        
 Lys Gln Asn Leu Met Gly Ile Gln Thr Asp Ser Ile His Leu Arg Glu
         435                 440                 445            
 Lys Met Arg Arg Glu Leu Thr Leu Gly Gln Ile Arg Ser Ser Thr Met
     450                 455                 460                
 Ser Asn Pro Asp His Phe Pro Gln Leu Leu Leu Pro Lys Asp Gln Val
 465                 470                 475                 480
 Ser Gly Lys Ala Val Cys Leu Ile Glu Glu Ile Ser Ser Thr Glu Ile
                 485                 490                 495    
 Gln Val Glu Met Lys Met Pro Ala Tyr Glu Leu Lys Ile Val His Asp
             500                 505                 510        
 His Ser Glu Lys Pro Leu Lys Ile Glu Leu Lys Val Glu Leu Pro Gly
         515                 520                 525            
 Ile Asn Ser Val Ser Leu Cys Asp Leu Ser Val Ser Glu Ser Pro Val
     530                 535                 540                
 Pro Asp Ser Pro Gln Leu Ser Ser Leu Gly Lys Ser Asp Ser Ser Phe
 545                 550                 555                 560
 Ser Glu Ile Ser Gly Leu Phe Tyr Lys Asp Glu Ala Leu Glu Lys Asp
                 565                 570                 575    
 Leu Asn Gly Pro Ser Gly Thr Leu Leu Pro Arg Ser Ala Pro Arg Pro
             580                 585                 590        
 Arg Ser Val Glu Lys Glu Arg Ala Cys Arg Ala Phe Leu Ala Trp Gly
         595                 600                 605            
 Ala Gly Gly Val Asn Leu Arg Glu Pro Phe Tyr Asp Asn Val Arg Leu
     610                 615                 620                
 Cys Gly Val Ala Asp Gly Asn Ala Ala Ala Leu Gly Glu Val Pro Leu
 625                 630                 635                 640
 Pro Ser Leu Ser Pro Thr Met Gln Ala Gly Thr Ile Ala Arg Trp Glu
                 645                 650                 655    
 Lys Lys Glu Gly Asp Lys Ile Asn Glu Gly Asp Leu Ile Ala Glu Val
             660                 665                 670        
 Glu Thr Asp Lys Ala Thr Val Gly Phe Glu Ser Leu Glu Glu Cys Tyr
         675                 680                 685            
 Met Ala Lys Ile Leu Val Ala Glu Gly Thr Arg Asp Val Pro Ile Gly
     690                 695                 700                
 Ala Ile Ile Cys Ile Thr Val Gly Lys Pro Glu Asp Ile Glu Ala Phe
 705                 710                 715                 720
 Lys Asn Tyr Thr Leu Asp Ser Ser Ala Ala Pro Thr Pro Gln Ala Ala
                 725                 730                 735    
 Pro Ala Pro Thr Pro Ala Ala Thr Ala Ser Pro Pro Thr Pro Ser Ala
             740                 745                 750        
 Gln Ala Pro Gly Ser Ser Tyr Pro Pro His Met Gln Leu Ala Glu Pro
         755                 760                 765            
 Phe Ala Pro Leu Ala Thr Ala Trp Thr Val Ser Lys Glu Leu Ser Pro
     770                 775                 780                
 Ser Ala Phe Cys Pro Pro Gly Cys Gln Arg Trp Leu Leu Lys Trp Leu
 785                 790                 795                 800
 Pro Pro Ala Ala Val Tyr Thr Ala Ser Gly Arg Gly Lys Glu Pro Gln
                 805                 810                 815    
 Thr Phe Gln Ile Ala Ser Ser Arg Asn Lys Leu Phe Val Ala Asp Met
             820                 825                 830        
 Gly Glu Tyr His Phe Arg Gly Glu Val Leu Lys Leu Phe Ala Leu Met
         835                 840                 845            
 Phe Pro Leu His
     850        



      <210> 1013
      <211> 1550
      <212> PRT
      <213> Homo sapiens


      <400> 1013
 Met Glu Cys Pro Ser Cys Gln His Val Ser Lys Glu Glu Thr Pro Lys
   1               5                  10                  15    
 Phe Cys Ser Gln Cys Gly Glu Arg Leu Pro Pro Ala Ala Pro Ile Ala
              20                  25                  30        
 Asp Ser Glu Asn Asn Asn Ser Thr Met Ala Ser Ala Ser Glu Gly Glu
          35                  40                  45            
 Met Glu Cys Gly Gln Glu Leu Lys Glu Glu Gly Gly Pro Cys Leu Phe
      50                  55                  60                
 Pro Gly Ser Asp Ser Trp Gln Glu Asn Pro Glu Glu Pro Cys Ser Lys
  65                  70                  75                  80
 Ala Ser Trp Thr Val Gln Glu Ser Lys Lys Lys Lys Arg Lys Lys Lys
                  85                  90                  95    
 Lys Lys Gly Asn Lys Ser Ala Ser Ser Glu Leu Ala Ser Leu Pro Leu
             100                 105                 110        
 Ser Pro Ala Ser Pro Cys His Leu Thr Leu Leu Ser Asn Pro Trp Pro
         115                 120                 125            
 Gln Asp Thr Ala Leu Pro His Ser Gln Ala Gln Gln Ser Gly Pro Thr
     130                 135                 140                
 Gly Gln Pro Ser Gln Pro Pro Gly Thr Ala Thr Thr Pro Leu Glu Gly
 145                 150                 155                 160
 Asp Gly Leu Ser Ala Pro Thr Glu Val Gly Asp Ser Pro Leu Gln Ala
                 165                 170                 175    
 Gln Ala Leu Gly Glu Ala Gly Val Ala Thr Gly Ser Glu Ala Gln Ser
             180                 185                 190        
 Ser Pro Gln Phe Gln Asp His Thr Glu Gly Glu Asp Gln Asp Ala Ser
         195                 200                 205            
 Ile Pro Ser Gly Gly Arg Gly Leu Ser Gln Glu Gly Thr Gly Pro Pro
     210                 215                 220                
 Thr Ser Ala Gly Glu Gly His Ser Arg Thr Glu Asp Ala Ala Gln Glu
 225                 230                 235                 240
 Leu Leu Leu Pro Glu Ser Lys Gly Gly Ser Ser Glu Pro Gly Thr Glu
                 245                 250                 255    
 Leu Gln Thr Thr Glu Gln Gln Ala Gly Ala Ser Ala Ser Met Ala Val
             260                 265                 270        
 Asp Ala Val Ala Glu Pro Ala Asn Ala Val Lys Gly Ala Gly Lys Glu
         275                 280                 285            
 Met Lys Glu Lys Thr Gln Arg Met Lys Gln Pro Pro Ala Thr Thr Pro
     290                 295                 300                
 Pro Phe Lys Thr His Cys Gln Glu Ala Glu Thr Lys Thr Lys Asp Glu
 305                 310                 315                 320
 Met Ala Ala Ala Glu Glu Lys Val Gly Lys Asn Glu Gln Gly Glu Pro
                 325                 330                 335    
 Glu Asp Leu Lys Lys Pro Glu Gly Lys Asn Arg Ser Ala Ala Ala Val
             340                 345                 350        
 Lys Asn Glu Lys Glu Gln Lys Asn Gln Glu Ala Asp Val Gln Glu Val
         355                 360                 365            
 Lys Ala Ser Thr Leu Ser Pro Gly Gly Gly Val Thr Val Phe Phe His
     370                 375                 380                
 Ala Ile Ile Ser Leu His Phe Pro Phe Asn Pro Asp Leu His Lys Val
 385                 390                 395                 400
 Phe Ile Arg Gly Gly Glu Glu Phe Gly Glu Ser Lys Trp Asp Ser Asn
                 405                 410                 415    
 Ile Cys Glu Leu His Tyr Thr Arg Asp Leu Gly His Asp Arg Val Leu
             420                 425                 430        
 Val Glu Gly Ile Val Cys Ile Ser Lys Lys His Leu Asp Lys Tyr Ile
         435                 440                 445            
 Pro Tyr Lys Tyr Val Ile Tyr Asn Gly Glu Ser Phe Glu Tyr Glu Phe
     450                 455                 460                
 Ile Tyr Lys His Gln Gln Lys Lys Gly Glu Tyr Val Asn Arg Cys Leu
 465                 470                 475                 480
 Phe Ile Lys Ser Ser Leu Leu Gly Ser Gly Asp Trp His Gln Tyr Tyr
                 485                 490                 495    
 Asp Ile Val Tyr Met Lys Pro His Gly Arg Leu Gln Lys Val Met Asn
             500                 505                 510        
 His Ile Thr Asp Gly Pro Arg Lys Asp Leu Val Lys Gly Lys Gln Ile
         515                 520                 525            
 Ala Ala Ala Leu Met Leu Asp Ser Thr Phe Ser Ile Leu Gln Thr Trp
     530                 535                 540                
 Asp Thr Ile Asn Leu Asn Ser Phe Phe Thr Gln Phe Glu Gln Phe Cys
 545                 550                 555                 560
 Phe Val Leu Gln Gln Pro Met Ile Tyr Glu Gly Gln Ala Gln Leu Trp
                 565                 570                 575    
 Thr Asp Leu Gln Tyr Arg Glu Lys Glu Val Lys Arg Tyr Leu Trp Gln
             580                 585                 590        
 His Leu Lys Lys His Val Val Pro Leu Pro Asp Gly Lys Ser Thr Asp
         595                 600                 605            
 Phe Leu Pro Val Asp Cys Pro Val Arg Ser Lys Leu Lys Thr Gly Leu
     610                 615                 620                
 Ile Val Leu Phe Val Val Glu Lys Ile Glu Leu Leu Leu Glu Gly Ser
 625                 630                 635                 640
 Leu Asp Trp Leu Cys His Leu Leu Thr Ser Asp Ala Ser Ser Pro Asp
                 645                 650                 655    
 Glu Phe His Arg Asp Leu Ser His Ile Leu Gly Ile Pro Gln Ser Trp
             660                 665                 670        
 Arg Leu Tyr Leu Val Asn Leu Cys Gln Arg Cys Met Asp Thr Arg Thr
         675                 680                 685            
 Tyr Thr Trp Leu Gly Ala Leu Pro Val Leu His Cys Cys Met Glu Leu
     690                 695                 700                
 Ala Pro Arg His Lys Asp Ala Trp Arg Gln Pro Glu Asp Thr Trp Ala
 705                 710                 715                 720
 Ala Leu Glu Gly Leu Ser Phe Ser Pro Phe Arg Glu Gln Met Leu Asp
                 725                 730                 735    
 Thr Ser Ser Leu Leu Gln Phe Met Arg Glu Lys Gln His Leu Leu Ser
             740                 745                 750        
 Ile Asp Glu Pro Leu Phe Arg Ser Trp Phe Ser Leu Leu Pro Leu Ser
         755                 760                 765            
 His Leu Val Met Tyr Met Glu Asn Phe Ile Glu His Leu Gly Arg Phe
     770                 775                 780                
 Pro Ala His Ile Leu Asp Cys Leu Ser Gly Ile Tyr Tyr Arg Leu Pro
 785                 790                 795                 800
 Gly Leu Glu Gln Val Leu Asn Thr Gln Asp Val Gln Asp Val Gln Asn
                 805                 810                 815    
 Val Gln Asn Ile Leu Glu Met Leu Leu Arg Leu Leu Asp Thr Tyr Arg
             820                 825                 830        
 Asp Lys Ile Pro Glu Glu Ala Leu Ser Pro Ser Tyr Leu Thr Val Cys
         835                 840                 845            
 Leu Lys Leu His Glu Ala Ile Cys Ser Ser Thr Lys Leu Leu Lys Phe
     850                 855                 860                
 Tyr Glu Leu Pro Ala Leu Ser Ala Glu Ile Val Cys Arg Met Ile Arg
 865                 870                 875                 880
 Leu Leu Ser Leu Val Asp Ser Ala Gly Gln Arg Asp Glu Thr Gly Asn
                 885                 890                 895    
 Asn Ser Val Gln Thr Val Phe Gln Gly Thr Leu Ala Ala Thr Lys Arg
             900                 905                 910        
 Trp Leu Arg Glu Val Phe Thr Lys Asn Met Leu Thr Ser Ser Gly Ala
         915                 920                 925            
 Ser Phe Thr Tyr Val Lys Glu Ile Glu Val Trp Arg Arg Leu Val Glu
     930                 935                 940                
 Ile Gln Phe Pro Ala Glu His Gly Trp Lys Glu Ser Leu Leu Gly Asp
 945                 950                 955                 960
 Met Glu Trp Arg Leu Thr Lys Glu Glu Pro Leu Ser Gln Ile Thr Ala
                 965                 970                 975    
 Tyr Cys Asn Ser Cys Trp Asp Thr Lys Gly Leu Glu Asp Ser Val Ala
             980                 985                 990        
 Lys Thr Phe Glu Lys Cys Ile Ile Glu Ala Val Ser Ser Ala Cys Gln
         995                1000                1005            
 Ser Gln Thr Ser Ile Leu Gln Gly Phe Ser Tyr Ser Asp Leu Arg Lys
    1010                1015                1020                
 Phe Gly Ile Val Leu Ser Ala Val Ile Thr Lys Ser Trp Pro Arg Thr
1025                1030                1035                1040
 Ala Asp Asn Phe Asp Asp Ile Leu Lys His Leu Leu Thr Leu Ala Asp
                1045                1050                1055    
 Val Lys His Val Phe Arg Leu Cys Gly Thr Asp Glu Lys Ile Leu Ala
            1060                1065                1070        
 Asn Val Thr Glu Asp Ala Lys Arg Leu Ile Ala Val Ala Asp Ser Val
        1075                1080                1085            
 Leu Thr Lys Val Val Gly Asp Leu Leu Ser Gly Thr Ile Leu Val Gly
    1090                1095                1100                
 Gln Leu Glu Leu Ile Ile Lys His Lys Asn Gln Phe Leu Asp Ile Trp
1105                1110                1115                1120
 Gln Leu Arg Glu Lys Ser Leu Ser Pro Gln Asp Glu Lys Cys Ala Val
                1125                1130                1135    
 Glu Glu Ala Leu Asp Trp Arg Arg Glu Glu Leu Leu Leu Leu Lys Lys
            1140                1145                1150        
 Glu Lys Arg Cys Val Asp Ser Leu Leu Lys Met Cys Gly Asn Val Lys
        1155                1160                1165            
 His Leu Ile Gln Val Asp Phe Gly Val Leu Ala Val Arg His Ser Gln
    1170                1175                1180                
 Asp Leu Ser Ser Lys Arg Leu Asn Asp Thr Met Thr Val Arg Leu Ser
1185                1190                1195                1200
 Thr Ser Ser Asn Ser Gln Arg Ala Thr His Tyr His Leu Ser Ser Gln
                1205                1210                1215    
 Val Gln Glu Met Ala Gly Lys Ile Asp Leu Leu Arg Asp Ser His Ile
            1220                1225                1230        
 Phe Gln Leu Phe Trp Arg Glu Ala Ala Glu Pro Leu Ser Glu Pro Lys
        1235                1240                1245            
 Glu Asp Gln Glu Ala Ala Glu Leu Leu Ser Glu Pro Glu Glu Glu Ser
    1250                1255                1260                
 Glu Arg His Ile Leu Glu Leu Gln Glu Val Tyr Asp Tyr Leu Tyr Gln
1265                1270                1275                1280
 Pro Ser Tyr Arg Lys Phe Ile Lys Leu His Gln Asp Leu Lys Ser Gly
                1285                1290                1295    
 Glu Val Thr Leu Ala Glu Ile Asp Val Ile Phe Lys Asp Phe Val Asn
            1300                1305                1310        
 Lys Tyr Thr Asp Leu Asp Ser Glu Leu Lys Ile Met Cys Thr Val Asp
        1315                1320                1325            
 His Gln Gly Gln Arg Asp Trp Ile Lys Asp Arg Val Glu Gln Ile Lys
    1330                1335                1340                
 Glu Tyr His His Leu His Gln Ala Val His Ala Ala Lys Val Ile Leu
1345                1350                1355                1360
 Gln Val Lys Glu Ser Leu Gly Leu Asn Gly Asp Phe Ser Val Leu Asn
                1365                1370                1375    
 Thr Leu Leu Asn Phe Thr Asp Asn Phe Asp Asp Phe Arg Arg Glu Thr
            1380                1385                1390        
 Leu Asp Gln Ile Asn Gln Glu Leu Ile Gln Ala Lys Lys Leu Leu Gln
        1395                1400                1405            
 Asp Ile Ser Glu Ala Arg Cys Lys Gly Leu Gln Ala Leu Ser Leu Arg
    1410                1415                1420                
 Lys Glu Phe Ile Cys Trp Val Arg Glu Ala Leu Gly Gly Ile Asn Glu
1425                1430                1435                1440
 Leu Lys Val Phe Val Asp Leu Ala Ser Ile Ser Ala Gly Glu Asn Asp
                1445                1450                1455    
 Ile Asp Val Asp Arg Val Ala Cys Phe His Asp Ala Val Gln Gly Tyr
            1460                1465                1470        
 Ala Ser Leu Leu Phe Lys Leu Asp Pro Ser Val Asp Phe Ser Ala Phe
        1475                1480                1485            
 Met Lys His Leu Lys Lys Leu Trp Lys Ala Leu Asp Lys Asp Gln Tyr
    1490                1495                1500                
 Leu Pro Arg Lys Leu Val Ser Leu Ile Leu Ser Leu Met Gln Ile Leu
1505                1510                1515                1520
 Leu Asn Arg Ala Leu Leu Ser Asn Val Arg Ala Val Thr Val Glu Met
                1525                1530                1535    
 Val Ala His Leu Cys Gly Arg Phe Val His Ser Arg Phe Gln
            1540                1545                1550



      <210> 1014
      <211> 564
      <212> PRT
      <213> Homo sapiens


      <400> 1014
 Met Asp Val Pro Ala Pro Asn Ala Pro Gly Val Arg Leu Gln Leu Lys
   1               5                  10                  15    
 Ala Glu Gly Cys Pro Glu Glu Leu Ala Val His Leu Gly Phe Asn Leu
              20                  25                  30        
 Cys Ala Glu Glu Gln Ala Phe Leu Ser Arg Arg Lys Gln Val Val Ala
          35                  40                  45            
 Lys Ala Leu Lys Gln Ala Leu Gln Leu Asp Arg Asp Leu Gln Glu Asp
      50                  55                  60                
 Glu Val Pro Val Val Gly Ile Met Ala Thr Gly Gly Gly Ala Arg Ala
  65                  70                  75                  80
 Met Thr Ser Leu Tyr Gly His Leu Leu Ala Leu Gln Lys Leu Gly Leu
                  85                  90                  95    
 Leu Asp Cys Val Thr Tyr Phe Ser Gly Ile Ser Gly Ser Thr Trp Thr
             100                 105                 110        
 Met Ala His Leu Tyr Gly Asp Pro Glu Trp Ser Gln Arg Asp Leu Glu
         115                 120                 125            
 Gly Pro Ile Arg Tyr Ala Arg Glu His Leu Ala Lys Ser Lys Leu Glu
     130                 135                 140                
 Val Phe Ser Pro Glu Arg Leu Ala Ser Tyr Arg Arg Glu Leu Glu Leu
 145                 150                 155                 160
 Arg Ala Glu Gln Gly His Pro Thr Thr Phe Val Asp Leu Trp Ala Leu
                 165                 170                 175    
 Val Leu Glu Ser Met Leu His Gly Gln Val Met Asp Gln Lys Leu Ser
             180                 185                 190        
 Gly Gln Arg Ala Ala Leu Glu Arg Gly Gln Asn Pro Leu Pro Leu Tyr
         195                 200                 205            
 Leu Ser Leu Asn Val Lys Glu Ser Asn Leu Glu Thr Leu Asp Phe Lys
     210                 215                 220                
 Glu Trp Val Glu Phe Ser Pro Tyr Glu Val Gly Phe Leu Lys Tyr Gly
 225                 230                 235                 240
 Ala Phe Val Pro Pro Glu Leu Phe Gly Ser Glu Phe Phe Met Gly Arg
                 245                 250                 255    
 Leu Met Arg Arg Ile Pro Glu Pro Arg Ile Cys Phe Leu Glu Ala Ile
             260                 265                 270        
 Trp Ser Asn Ile Phe Ser Leu Asn Leu Leu Asp Ala Trp Tyr Asp Leu
         275                 280                 285            
 Thr Ser Ser Gly Glu Ser Trp Lys Gln His Ile Lys Asp Lys Thr Arg
     290                 295                 300                
 Ser Leu Glu Lys Glu Pro Leu Thr Thr Ser Gly Thr Ser Ser Arg Leu
 305                 310                 315                 320
 Glu Ala Ser Trp Leu Gln Pro Gly Thr Ala Leu Ala Gln Ala Phe Lys
                 325                 330                 335    
 Gly Phe Leu Thr Gly Arg Pro Leu His Gln Arg Ser Pro Asn Phe Leu
             340                 345                 350        
 Gln Gly Leu Gln Leu His Gln Asp Tyr Cys Ser His Lys Asp Phe Ser
         355                 360                 365            
 Thr Trp Ala Asp Tyr Gln Leu Asp Ser Met Pro Ser Gln Leu Thr Pro
     370                 375                 380                
 Lys Glu Pro Arg Leu Cys Leu Val Asp Ala Ala Tyr Phe Ile Asn Thr
 385                 390                 395                 400
 Ser Ser Pro Ser Met Phe Arg Pro Gly Arg Arg Leu Asp Leu Ile Leu
                 405                 410                 415    
 Ser Phe Asp Tyr Ser Leu Ser Ala Pro Phe Glu Ala Leu Gln Gln Thr
             420                 425                 430        
 Glu Leu Tyr Cys Arg Ala Arg Gly Leu Pro Phe Pro Arg Val Glu Pro
         435                 440                 445            
 Ser Pro Gln Asp Gln His Gln Pro Arg Glu Cys His Leu Phe Ser Asp
     450                 455                 460                
 Pro Ala Cys Pro Glu Ala Pro Ile Leu Leu His Phe Pro Leu Val Asn
 465                 470                 475                 480
 Ala Ser Phe Lys Asp His Ser Ala Pro Gly Val Gln Arg Ser Pro Ala
                 485                 490                 495    
 Glu Leu Gln Gly Gly Gln Val Asp Leu Thr Gly Ala Thr Cys Pro Tyr
             500                 505                 510        
 Thr Leu Ser Asn Met Thr Tyr Lys Glu Glu Asp Phe Glu Arg Leu Leu
         515                 520                 525            
 Arg Leu Ser Asp Tyr Asn Val Gln Thr Ser Gln Gly Ala Ile Leu Gln
     530                 535                 540                
 Ala Leu Arg Thr Ala Leu Lys His Arg Thr Leu Glu Ala Arg Pro Pro
 545                 550                 555                 560
 Arg Ala Gln Thr
                



      <210> 1015
      <211> 94
      <212> PRT
      <213> Homo sapiens


      <400> 1015
 Met Pro Phe Thr Lys Ser Thr Phe Tyr Phe Phe Tyr Met Asn Pro Phe
   1               5                  10                  15    
 His Asp Leu His Arg Pro Ser Met Thr Cys Leu Asp Phe Leu Thr Cys
              20                  25                  30        
 Pro Lys His Pro Ser Leu Asn Asn His Ser Phe Asn Phe Arg Ala Arg
          35                  40                  45            
 Ile Tyr His Thr Gly Ser Cys Leu Ile Gln Asn Tyr Tyr Cys Tyr Ile
      50                  55                  60                
 Leu Pro Tyr Gln Glu Tyr Ile Phe Ile Tyr Ile Thr Phe Phe Thr Ser
  65                  70                  75                  80
 Leu Ser Arg Thr Tyr Trp Phe Leu Thr Thr Leu Phe His Lys
                  85                  90                



      <210> 1016
      <211> 778
      <212> PRT
      <213> Homo sapiens


      <400> 1016
 Met Gln Gln Glu Ser Glu Arg Cys Arg Val Arg Ala Arg Arg Pro Asp
   1               5                  10                  15    
 Met Ala Leu Tyr Val Pro Lys Ala Arg Arg Gly Ala Val Leu Leu Lys
              20                  25                  30        
 Thr Gly Asp Glu Glu Glu Ser Cys Gly Ser Pro Asn Ser Val Val Lys
          35                  40                  45            
 Glu Lys Gln Lys Glu Ser Ser Leu Ser Gln Lys Glu Val Phe Lys Asp
      50                  55                  60                
 Lys Pro Glu Ala Arg Arg Leu Asn Ile Asn Pro Asp Arg Lys Glu His
  65                  70                  75                  80
 Asn Cys Arg Glu Glu Lys Lys Ser Ser Thr Lys Leu Arg Met Asp Thr
                  85                  90                  95    
 Cys Leu Gln Lys Thr Asn Arg Val Cys Ser Lys Arg Gly Thr Thr Glu
             100                 105                 110        
 Ser Lys Glu Val Leu Ser Gln Gly Gln Gln Gln Gly Ala Pro Asn Ala
         115                 120                 125            
 Gly Val Ile Thr Asn Ala Pro Leu Gln Arg His Phe Lys Pro Lys Lys
     130                 135                 140                
 Val Glu Cys Leu Glu Val Glu Thr Thr Asp Val Thr Gly His Glu Arg
 145                 150                 155                 160
 Ile Leu Leu Ser Gln Ala Cys Leu Glu Ile Ser Glu Ala Gln Val Pro
                 165                 170                 175    
 Ser Lys Pro Phe Gln Asn Val Glu Phe Cys Asp Phe Ser Arg His Glu
             180                 185                 190        
 Pro Asp Gly Glu Ala Phe Glu Asp Lys Asp Leu Glu Gly Arg Ile Glu
         195                 200                 205            
 Thr Asp Thr Lys Val Leu Glu Ile Leu Tyr Glu Phe Pro Arg Val Phe
     210                 215                 220                
 Ser Ser Val Met Lys Pro Glu Asn Met Ile Val Pro Ile Lys Leu Ser
 225                 230                 235                 240
 Ser Asp Ser Glu Ile Val Gln Gln Ser Met Gln Thr Ser Asp Gly Ile
                 245                 250                 255    
 Leu Asn Pro Ser Ser Gly Gly Ile Thr Thr Thr Ser Val Pro Gly Ser
             260                 265                 270        
 Pro Asp Gly Val Phe Asp Gln Thr Cys Val Asp Phe Glu Val Glu Ser
         275                 280                 285            
 Val Gly Gly Ile Ala Asn Ser Thr Gly Phe Ile Leu Asp Gln Lys Asp
     290                 295                 300                
 Thr Asp Ser Ile Pro Ala Thr Met Gly His Ile Ser Leu Ser Glu Ser
 305                 310                 315                 320
 Thr Asn Asp Thr Val Ser Pro Val Met Ile Arg Glu Cys Glu Lys Asn
                 325                 330                 335    
 Asp Ser Thr Ala Asp Glu Leu His Val Lys His Glu Pro Pro Asp Thr
             340                 345                 350        
 Ala Val Leu Ala His Glu Thr His Arg Asp Ser Gly Phe Lys Asn Val
         355                 360                 365            
 Gly Asp Ile Thr Asn Lys Ala Cys Met Met Asp Thr Thr Gly Met Ser
     370                 375                 380                
 Cys Ser Asp His Val Thr Val Asp Ser Pro Tyr Val Val Ala Val Arg
 385                 390                 395                 400
 Ile Ala Asp Glu Thr Ser Ile Asn Thr Arg Ser Phe Ser Lys Phe Val
                 405                 410                 415    
 Gly Met Ser Ala Asp Ala Thr Pro Leu His Val Ala Arg Ser Gly Asn
             420                 425                 430        
 Asp Thr Glu Asp Phe Ser Asn Pro Ser Ala Cys Ser Asp Ile Tyr Gly
         435                 440                 445            
 Glu Ser Ile Ser Ser His Phe Thr Glu Ser Thr Gly Lys Leu Ile Glu
     450                 455                 460                
 Ser Leu Ser Asp Cys Ala Ser Ser Leu Pro Ile Lys Lys Ile Ala Gly
 465                 470                 475                 480
 Ser Asn Tyr Asn Thr Phe Leu Asp Ser Glu Leu Ser Met Leu Asn Gly
                 485                 490                 495    
 Thr Lys Val Leu Ser Asp Ser Ala Val Gly Ile Asp Leu Gly Ser Thr
             500                 505                 510        
 Gly Asp Thr Thr Glu Ala Leu His Glu Leu Arg Thr Ala Glu Glu Phe
         515                 520                 525            
 Lys Thr Glu Glu Gln Asp Asp Ser Gly Ser Ile Glu Phe Gly Val Ser
     530                 535                 540                
 Phe Pro Asp Arg Glu Ser Ser Ser Met Glu Thr Ser Ile Glu Pro Lys
 545                 550                 555                 560
 Ala Thr Glu Thr Ser Arg Thr Glu Gly Ile Thr Ala Ile Glu Glu Ser
                 565                 570                 575    
 Trp Glu Ser Met Phe Asn Asp Asp Gly Asp Cys Leu Asp Pro Arg Leu
             580                 585                 590        
 Leu Gln Glu Leu Ser Gly Asn Thr Lys Ser Arg Glu Ser Ile Gln Glu
         595                 600                 605            
 Pro Arg Ser Asp Tyr Tyr Asn His Glu Val Pro Asp Ile Asp Leu Ser
     610                 615                 620                
 Asp Cys Glu Phe Pro His Val Ile Glu Ile Tyr Asp Phe Pro Gln Glu
 625                 630                 635                 640
 Phe Arg Thr Glu Asp Leu Leu Arg Val Phe Cys Ser Tyr Gln Lys Lys
                 645                 650                 655    
 Gly Phe Asp Ile Lys Trp Val Asp Asp Thr His Ala Leu Gly Val Phe
             660                 665                 670        
 Ser Ser Pro Ile Thr Ala Arg Asp Ala Leu Gly Ile Lys His Thr Met
         675                 680                 685            
 Val Lys Ile Arg Pro Leu Ser Gln Ala Thr Arg Ala Ala Lys Ala Lys
     690                 695                 700                
 Ala Arg Ala Tyr Ala Glu Phe Leu Gln Pro Ala Lys Glu Arg Pro Glu
 705                 710                 715                 720
 Thr Ser Ala Ala Leu Ala Arg Arg Leu Val Ile Ser Ala Leu Gly Val
                 725                 730                 735    
 Arg Ser Lys Gln Ser Lys Thr Glu Arg Glu Ala Glu Leu Lys Lys Leu
             740                 745                 750        
 Gln Glu Ala Arg Glu Arg Lys Arg Leu Glu Ala Lys Gln Arg Glu Asp
         755                 760                 765            
 Ile Trp Glu Gly Arg Asp Gln Ser Thr Val
     770                 775            



      <210> 1017
      <211> 301
      <212> PRT
      <213> Homo sapiens


      <400> 1017
 Met Ser Gln Gly Thr Thr Pro Trp Gly Pro Thr Pro Ala Gly Pro Thr
   1               5                  10                  15    
 Pro Ala Gly Thr Thr Pro Glu Ser Glu Arg Asp Thr Glu Phe Gln Glu
              20                  25                  30        
 His Glu Lys Ile Leu Ser Pro Asp Phe Leu Ser Val Ala Gln Ile Thr
          35                  40                  45            
 Asp Leu Leu Met Glu Asp Ile Asp Gly Val Gln Glu Lys Leu Arg Ile
      50                  55                  60                
 Phe Leu Asn Phe Lys Asn Leu Glu Thr Cys Leu Lys Asp Ala Ile Leu
  65                  70                  75                  80
 Leu Asp Tyr Tyr Val Ser Gly Phe Leu Trp Ala Arg Gly Met Asp Phe
                  85                  90                  95    
 Ser Ile Ile Gln Tyr Ser Lys Phe Met Thr Leu Leu Ala Met Ser Leu
             100                 105                 110        
 Gln Asn Leu Lys Thr Leu His Met Ser Leu Glu Glu Ser Ile Lys Trp
         115                 120                 125            
 Leu Gly Glu Val Met Ala Glu Ile Gly Pro Thr His Ser Gln Lys Ser
     130                 135                 140                
 Glu Asp Trp Asn Ile Phe Asp Val Lys Gln Ala Asn Ala Ile Ile Asp
 145                 150                 155                 160
 Tyr Leu Lys Ile Ser Leu Phe Gln His Tyr Lys Leu Tyr Glu Phe Met
                 165                 170                 175    
 Phe Tyr Ser Ala Arg Glu Glu Ile Val Ile Gly Thr Glu Gln Val Ile
             180                 185                 190        
 Glu Val Val Lys Ser Ala Cys Gly Pro Phe Pro Asn Pro Leu Glu Glu
         195                 200                 205            
 Gly Ile Ser Phe Asp Ile Tyr Ser Thr Phe Ile Glu Pro Pro Thr Ile
     210                 215                 220                
 Leu Asp Thr Glu Met Lys Arg Leu Asp Gln Glu Gln Gly Pro Glu Glu
 225                 230                 235                 240
 Ser Gln Pro Glu Thr Asp Thr Ser Asp Met Asp Pro Leu Val Gly Phe
                 245                 250                 255    
 Thr Ile Glu Asp Val Lys Ser Val Leu Asp Gln Val Thr Asp Asp Ile
             260                 265                 270        
 Leu Ile Gly Ile Gln Thr Glu Ile Asn Glu Lys Leu Gln Ile Gln Glu
         275                 280                 285            
 Glu Ala Phe Asn Ala Arg Ile Glu Lys Leu Lys Lys Ala
     290                 295                 300    



      <210> 1018
      <211> 58
      <212> PRT
      <213> Homo sapiens


      <400> 1018
 Met Ala Gly Phe Leu Asp Asn Phe Arg Trp Pro Glu Cys Glu Cys Ile
   1               5                  10                  15    
 Asp Trp Ser Glu Arg Arg Asn Val Val Ala Ser Val Val Ala Gly Ile
              20                  25                  30        
 Leu Val Ser Glu Lys Asp Trp Leu Val Thr Cys Ile Pro Tyr Leu Leu
          35                  40                  45            
 Pro Trp Lys Leu Met Pro Val Pro Leu Asn
      50                  55            



      <210> 1019
      <211> 107
      <212> PRT
      <213> Homo sapiens


      <400> 1019
 Met Gln Glu Asp Arg Asp Gly Ser Cys Ser Thr Val Gly Gly Val Gly
   1               5                  10                  15    
 Tyr Gly Gly Glu Tyr Gly Ala Pro Glu Ala Arg Leu Met Cys Leu Pro
              20                  25                  30        
 Phe Ser Met Thr Gly Cys Ala Thr Asp Leu Trp Ser Asp Pro Arg Ser
          35                  40                  45            
 Pro Ser Ala Leu Gly Pro Pro Gly Phe Asp Trp Ala Pro Arg Val Val
      50                  55                  60                
 Ala Gln Arg Asp Gly Leu Glu Pro Val Ala Ala Thr Trp Leu Gly Leu
  65                  70                  75                  80
 Pro Gly Asp Gly Gly Glu Asn Ala Met Gly Trp Arg Arg Lys Cys His
                  85                  90                  95    
 Gly Met Ala Phe Pro Ser Ala Gly Glu Ala Pro
             100                 105        



      <210> 1020
      <211> 798
      <212> PRT
      <213> Homo sapiens


      <400> 1020
 Met Gly Asp Met Lys Thr Pro Asp Phe Asp Asp Leu Leu Ala Ala Phe
   1               5                  10                  15    
 Asp Ile Pro Asp Ile Asp Ala Asn Glu Ala Ile His Ser Gly Pro Glu
              20                  25                  30        
 Glu Asn Glu Gly Pro Gly Gly Pro Gly Lys Pro Glu Pro Gly Val Gly
          35                  40                  45            
 Ser Glu Ser Glu Asp Thr Ala Ala Ala Ser Ala Gly Asp Gly Pro Gly
      50                  55                  60                
 Val Pro Ala Gln Ala Ser Asp His Gly Leu Pro Pro Pro Asp Ile Ser
  65                  70                  75                  80
 Val Val Ser Val Ile Val Lys Asn Thr Val Cys Pro Glu Gln Ser Glu
                  85                  90                  95    
 Ala Leu Ala Gly Gly Ser Ala Gly Asp Gly Ala Gln Ala Ala Gly Val
             100                 105                 110        
 Thr Lys Glu Gly Pro Val Gly Pro His Arg Met Gln Asn Gly Phe Gly
         115                 120                 125            
 Ser Pro Glu Pro Ser Leu Pro Gly Thr Pro His Ser Pro Ala Pro Pro
     130                 135                 140                
 Ser Gly Gly Thr Trp Lys Glu Lys Gly Met Glu Gly Lys Thr Pro Leu
 145                 150                 155                 160
 Asp Leu Phe Ala His Phe Gly Pro Glu Pro Gly Asp His Ser Asp Pro
                 165                 170                 175    
 Leu Pro Pro Ser Ala Pro Ser Pro Thr Arg Glu Gly Ala Leu Thr Pro
             180                 185                 190        
 Pro Pro Phe Pro Ser Ser Phe Glu Leu Ala Gln Glu Asn Gly Pro Gly
         195                 200                 205            
 Met Gln Pro Pro Val Ser Ser Pro Pro Leu Gly Ala Leu Lys Gln Glu
     210                 215                 220                
 Ser Cys Ser Pro His His Pro Gln Val Leu Ala Gln Gln Gly Ser Gly
 225                 230                 235                 240
 Ser Ser Pro Lys Ala Thr Asp Ile Pro Ala Ser Ala Ser Pro Pro Pro
                 245                 250                 255    
 Val Ala Gly Val Pro Phe Phe Lys Gln Ser Pro Gly His Gln Ser Pro
             260                 265                 270        
 Leu Ala Ser Pro Lys Val Pro Val Cys Gln Pro Leu Lys Glu Glu Asp
         275                 280                 285            
 Asp Asp Glu Gly Pro Val Asp Lys Ser Ser Pro Gly Ser Pro Gln Ser
     290                 295                 300                
 Pro Ser Ser Gly Ala Glu Ala Ala Asp Glu Asp Ser Asn Asp Ser Pro
 305                 310                 315                 320
 Ala Ser Ser Ser Ser Arg Pro Leu Lys Val Arg Ile Lys Thr Ile Lys
                 325                 330                 335    
 Thr Ser Cys Gly Asn Ile Thr Arg Thr Val Thr Gln Val Pro Ser Asp
             340                 345                 350        
 Pro Asp Pro Pro Ala Pro Leu Ala Glu Gly Ala Phe Leu Ala Glu Ala
         355                 360                 365            
 Ser Leu Leu Lys Leu Ser Pro Ala Thr Pro Thr Ser Glu Gly Pro Lys
     370                 375                 380                
 Val Val Ser Val Gln Leu Gly Asp Gly Thr Arg Leu Lys Gly Thr Val
 385                 390                 395                 400
 Leu Pro Val Ala Thr Ile Gln Asn Ala Ser Thr Ala Met Leu Met Ala
                 405                 410                 415    
 Ala Ser Val Ala Arg Lys Ala Val Val Leu Pro Gly Gly Thr Ala Thr
             420                 425                 430        
 Ser Pro Lys Met Ile Ala Lys Asn Val Leu Gly Leu Val Pro Gln Ala
         435                 440                 445            
 Leu Pro Lys Ala Asp Gly Arg Ala Gly Leu Gly Thr Gly Gly Gln Lys
     450                 455                 460                
 Val Asn Gly Ala Ser Val Val Met Val Gln Pro Ser Lys Thr Ala Thr
 465                 470                 475                 480
 Gly Pro Ser Thr Gly Gly Gly Thr Val Ile Ser Arg Thr Gln Ser Ser
                 485                 490                 495    
 Leu Val Glu Ala Phe Asn Lys Ile Leu Asn Ser Lys Asn Leu Leu Pro
             500                 505                 510        
 Ala Tyr Arg Pro Asn Leu Ser Pro Pro Ala Glu Ala Gly Leu Ala Leu
         515                 520                 525            
 Pro Pro Thr Gly Tyr Arg Cys Leu Glu Cys Gly Asp Ala Phe Ser Leu
     530                 535                 540                
 Glu Lys Ser Leu Ala Arg His Tyr Asp Arg Arg Ser Met Arg Ile Glu
 545                 550                 555                 560
 Val Thr Cys Asn His Cys Ala Arg Arg Leu Val Phe Phe Asn Lys Cys
                 565                 570                 575    
 Ser Leu Leu Leu His Ala Arg Glu His Lys Asp Lys Gly Leu Val Met
             580                 585                 590        
 Gln Cys Ser His Leu Val Met Arg Pro Val Ala Leu Asp Gln Met Val
         595                 600                 605            
 Gly Gln Pro Asp Ile Thr Pro Leu Leu Pro Val Ala Val Pro Pro Val
     610                 615                 620                
 Ser Gly Pro Leu Ala Leu Pro Ala Leu Gly Lys Ser Glu Gly Ala Ile
 625                 630                 635                 640
 Thr Ser Ser Ala Ile Thr Thr Val Ala Ala Glu Ala Pro Val Leu Pro
                 645                 650                 655    
 Leu Ser Thr Glu Pro Pro Ala Ala Pro Ala Thr Ser Ala Tyr Thr Cys
             660                 665                 670        
 Phe Arg Cys Leu Glu Cys Lys Glu Gln Cys Arg Asp Lys Ala Gly Met
         675                 680                 685            
 Ala Ala His Phe Gln Gln Leu Gly Pro Pro Ala Pro Gly Ala Thr Ser
     690                 695                 700                
 Asn Val Cys Pro Thr Cys Pro Met Met Leu Pro Asn Arg Cys Ser Phe
 705                 710                 715                 720
 Ser Ala His Gln Arg Met His Lys Asn Arg Pro Pro His Val Cys Pro
                 725                 730                 735    
 Glu Cys Gly Gly Asn Phe Leu Gln Ala Asn Phe Gln Thr His Leu Arg
             740                 745                 750        
 Glu Ala Cys Leu His Val Ser Arg Arg Val Gly Tyr Arg Cys Pro Ser
         755                 760                 765            
 Cys Ser Val Val Phe Gly Gly Val Asn Ser Ile Lys Ser His Ile Gln
     770                 775                 780                
 Thr Ser His Cys Glu Val Phe Gln Ser Thr Arg Pro Arg Ile
 785                 790                 795            



      <210> 1021
      <211> 222
      <212> PRT
      <213> Homo sapiens


      <400> 1021
 Met Ala Ala Pro Val Val Thr Ala Pro Gly Arg Ala Leu Leu Arg Ala
   1               5                  10                  15    
 Gly Ala Gly Arg Leu Leu Arg Gly Gly Val Gln Glu Leu Leu Arg Pro
              20                  25                  30        
 Arg His Glu Gly Asn Ala Pro Asp Leu Ala Cys Asn Phe Ser Leu Ser
          35                  40                  45            
 Gln Asn Arg Gly Thr Val Ile Val Glu Arg Trp Trp Lys Val Pro Leu
      50                  55                  60                
 Ala Gly Glu Gly Arg Lys Pro Arg Leu His Arg Arg His Arg Val Tyr
  65                  70                  75                  80
 Lys Leu Val Glu Asp Thr Lys His Arg Pro Lys Glu Asn Leu Glu Leu
                  85                  90                  95    
 Ile Leu Thr Gln Ser Val Glu Asn Val Gly Val Arg Gly Asp Leu Val
             100                 105                 110        
 Ser Val Lys Lys Ser Leu Gly Arg Asn Arg Leu Leu Pro Gln Gly Leu
         115                 120                 125            
 Ala Val Tyr Ala Ser Pro Glu Asn Lys Lys Leu Phe Glu Glu Glu Lys
     130                 135                 140                
 Leu Leu Arg Gln Glu Gly Lys Leu Glu Lys Ile Gln Thr Lys Ala Gly
 145                 150                 155                 160
 Glu Ala Thr Val Lys Phe Leu Lys Ser Cys Arg Leu Glu Val Gly Met
                 165                 170                 175    
 Lys Asn Asn Val Lys Trp Glu Leu Asn Pro Glu Ile Val Ala Arg His
             180                 185                 190        
 Phe Phe Lys Asn Val Asn Gly Leu Asp Thr Val Arg Val Pro Met Ser
         195                 200                 205            
 Val Val Asn Phe Glu Lys Pro Lys Thr Lys Arg Tyr Lys Tyr
     210                 215                 220        



      <210> 1022
      <211> 271
      <212> PRT
      <213> Homo sapiens


      <400> 1022
 Met Ser Ser Thr Gln Phe Asn Lys Gly Pro Ser Tyr Gly Leu Ser Ala
   1               5                  10                  15    
 Glu Val Lys Asn Arg Leu Leu Ser Lys Tyr Asp Pro Gln Lys Glu Ala
              20                  25                  30        
 Glu Leu Arg Thr Trp Ile Glu Gly Leu Thr Gly Leu Ser Ile Gly Pro
          35                  40                  45            
 Asp Phe Gln Lys Gly Leu Lys Asp Gly Thr Ile Leu Cys Thr Leu Met
      50                  55                  60                
 Asn Lys Leu Gln Pro Gly Ser Val Pro Lys Ile Asn Arg Ser Met Gln
  65                  70                  75                  80
 Asn Trp His Gln Leu Glu Asn Leu Ser Asn Phe Ile Lys Ala Met Val
                  85                  90                  95    
 Ser Tyr Gly Met Asn Pro Val Asp Leu Phe Glu Ala Asn Asp Leu Phe
             100                 105                 110        
 Glu Ser Gly Asn Asn Met Gln Val Arg Val Ser Leu Leu Ala Leu Ala
         115                 120                 125            
 Gly Lys Ala Lys Thr Lys Gly Leu Arg Ser Gly Val Asp Ile Arg Asp
     130                 135                 140                
 Lys Tyr Ser Lys Lys Gln Asn Phe Asp Asp Thr Thr Met Lys Ala Ser
 145                 150                 155                 160
 Gln Cys Val Ile Arg Leu Gln Met Gly Thr Asn Lys Cys Ala Ser Gln
                 165                 170                 175    
 Ser Gly Met Thr Ala Tyr Gly Thr Arg Arg His Leu Tyr Asp Pro Lys
             180                 185                 190        
 Asn Arg Ile Leu Pro Pro Met Asp Asn Ser Thr Ile Ser Leu Gln Met
         195                 200                 205            
 Gly Thr Asn Lys Tyr Ala Ser Gln Val Gly Met Thr Ala Pro Gly Thr
     210                 215                 220                
 Gln Arg His Ile Tyr Asp Thr Asn Leu Gly Ile Asp Lys Cys Glu Asn
 225                 230                 235                 240
 Ser Ser Met Ser Leu Lys Met Gly Tyr Thr Gln Val Ala Asn His Ser
                 245                 250                 255    
 Gly Gln Val Phe Gly Leu Gly Arg Gln Ile Tyr Glu Pro Lys Tyr
             260                 265                 270    



      <210> 1023
      <211> 627
      <212> PRT
      <213> Homo sapiens


      <400> 1023
 Met Glu Arg Ser Leu His Arg Val Ser Leu Gly Ser Arg Arg Ala His
   1               5                  10                  15    
 Pro Asp Leu Ser Phe Tyr Leu Thr Thr Phe Gly Gln Leu Arg Leu Ser
              20                  25                  30        
 Ile Asp Ala Gln Asp Arg Val Leu Leu Leu His Ile Ile Glu Gly Lys
          35                  40                  45            
 Gly Leu Ile Ser Lys Gln Pro Gly Thr Cys Asp Pro Tyr Val Lys Cys
      50                  55                  60                
 Leu Pro Thr Val Asp Val Met Asp Ser Ser Ile Cys Gln Ala Phe Thr
  65                  70                  75                  80
 Lys Cys Thr Lys Pro Gly Ala Gln Gly Leu Val Val Arg Ile Asn Gln
                  85                  90                  95    
 Gly Leu Val Pro Glu Thr Leu His Leu Val Arg Val Gln Ala Leu Pro
             100                 105                 110        
 Arg Glu Ile Ser Gly Trp Tyr Tyr Leu Leu Gly Glu His Leu Gly Arg
         115                 120                 125            
 Thr Lys His Leu Lys Val Ala Arg Arg Arg Leu Arg Pro Leu Arg Asp
     130                 135                 140                
 Pro Leu Leu Arg Met Pro Gly Gly Gly Asp Thr Glu Asn Gly Lys Lys
 145                 150                 155                 160
 Leu Lys Gly Ala His Ala Arg Leu Thr Gly Pro Val Arg Ala Pro Ala
                 165                 170                 175    
 Ala Gly Gly Glu Leu Gly Phe His Gly Ala Ala Ala Glu Ala Gly Pro
             180                 185                 190        
 Ala Ala Met Asn Arg Phe Asn Gly Leu Cys Lys Val Cys Ser Glu Arg
         195                 200                 205            
 Arg Tyr Arg Gln Ile Thr Ile Pro Arg Gly Lys Asp Gly Phe Gly Phe
     210                 215                 220                
 Thr Ile Cys Cys Asp Ser Pro Val Arg Val Gln Ala Val Asp Ser Gly
 225                 230                 235                 240
 Gly Pro Ala Glu Arg Ala Gly Leu Gln Gln Leu Asp Thr Val Leu Gln
                 245                 250                 255    
 Leu Asn Glu Arg Pro Val Glu His Trp Lys Cys Val Glu Leu Ala His
             260                 265                 270        
 Glu Ile Arg Ser Cys Pro Ser Glu Ile Ile Leu Leu Val Trp Arg Met
         275                 280                 285            
 Val Pro Gln Val Lys Pro Gly Pro Asp Gly Gly Val Leu Arg Arg Ala
     290                 295                 300                
 Ser Cys Lys Ser Thr His Asp Leu Gln Ser Pro Pro Asn Lys Arg Glu
 305                 310                 315                 320
 Lys Asn Cys Thr His Gly Val Gln Ala Arg Pro Glu Gln Arg His Ser
                 325                 330                 335    
 Cys His Leu Val Cys Asp Ser Ser Asp Gly Leu Leu Leu Gly Gly Trp
             340                 345                 350        
 Glu Arg Tyr Thr Glu Val Ala Lys Arg Gly Gly Gln His Thr Leu Pro
         355                 360                 365            
 Ala Leu Ser Arg Ala Thr Ala Pro Thr Asp Pro Asn Tyr Ile Ile Leu
     370                 375                 380                
 Ala Pro Leu Asn Pro Gly Ser Gln Leu Leu Arg Pro Val Tyr Gln Glu
 385                 390                 395                 400
 Asp Thr Ile Pro Glu Glu Ser Gly Ser Pro Ser Lys Gly Lys Ser Tyr
                 405                 410                 415    
 Thr Gly Leu Gly Lys Lys Ser Arg Leu Met Lys Thr Val Gln Thr Met
             420                 425                 430        
 Lys Gly His Gly Asn Tyr Gln Asn Cys Pro Val Val Arg Pro His Ala
         435                 440                 445            
 Thr His Ser Ser Tyr Gly Thr Tyr Val Thr Leu Ala Pro Lys Val Leu
     450                 455                 460                
 Val Phe Pro Val Phe Val Gln Pro Leu Asp Leu Cys Asn Pro Ala Arg
 465                 470                 475                 480
 Thr Leu Leu Leu Ser Glu Glu Leu Leu Leu Tyr Glu Gly Arg Asn Lys
                 485                 490                 495    
 Ala Ala Glu Val Thr Leu Phe Ala Tyr Ser Asp Leu Leu Leu Phe Thr
             500                 505                 510        
 Lys Glu Asp Glu Pro Gly Arg Cys Asp Val Leu Arg Asn Pro Leu Tyr
         515                 520                 525            
 Leu Gln Ser Val Lys Leu Gln Glu Gly Ser Ser Glu Asp Leu Lys Phe
     530                 535                 540                
 Cys Val Leu Tyr Leu Ala Glu Lys Ala Glu Cys Leu Phe Thr Leu Glu
 545                 550                 555                 560
 Ala His Ser Gln Glu Gln Lys Lys Arg Val Cys Trp Cys Leu Ser Glu
                 565                 570                 575    
 Asn Ile Ala Lys Gln Gln Gln Leu Ala Ala Ser Pro Pro Asp Ser Lys
             580                 585                 590        
 Lys Leu His Pro Phe Gly Ser Leu Gln Gln Glu Met Gly Pro Val Asn
         595                 600                 605            
 Ser Thr Asn Ala Thr Gln Asp Arg Ser Phe Thr Ser Pro Gly Gln Thr
     610                 615                 620                
 Leu Ile Gly
 625        



      <210> 1024
      <211> 178
      <212> PRT
      <213> Homo sapiens


      <400> 1024
 Met Glu Ile Glu Ser Thr Phe His Met Tyr Val Gln Pro Val Val His
   1               5                  10                  15    
 Pro Gln Leu Thr Pro Phe Cys Thr Glu Leu Thr Gly Ile Ile Gln Ala
              20                  25                  30        
 Met Val Asp Gly Gln Pro Ser Leu Gln Gln Val Leu Glu Arg Val Asp
          35                  40                  45            
 Glu Trp Met Ala Lys Glu Gly Leu Leu Asp Pro Asn Val Lys Ser Ile
      50                  55                  60                
 Phe Val Thr Cys Gly Asp Trp Asp Leu Lys Val Met Leu Pro Gly Gln
  65                  70                  75                  80
 Cys Gln Tyr Leu Gly Leu Pro Val Ala Asp Tyr Phe Lys Gln Trp Ile
                  85                  90                  95    
 Asn Leu Lys Lys Ala Tyr Ser Phe Ala Met Gly Cys Trp Pro Lys Asn
             100                 105                 110        
 Gly Leu Leu Asp Met Asn Lys Gly Leu Ser Leu Gln His Ile Gly Arg
         115                 120                 125            
 Pro His Ser Gly Ile Val Ser Ser Phe Cys Lys Glu Ser Val Leu Val
     130                 135                 140                
 Val Gln Ala Ile Leu Glu Glu Asp Asp Cys Lys Asn Ile Ala Asn Ile
 145                 150                 155                 160
 Met Lys Thr Leu Ala Tyr Arg Gly Phe Ile Phe Lys Gln Thr Ser Lys
                 165                 170                 175    
 Pro Phe
        



      <210> 1025
      <211> 253
      <212> PRT
      <213> Homo sapiens


      <400> 1025
 Met Gly Ala Asn Thr Ser Arg Lys Pro Pro Val Phe Asp Glu Asn Glu
   1               5                  10                  15    
 Asp Val Asn Phe Asp His Phe Glu Ile Leu Arg Ala Ile Gly Lys Gly
              20                  25                  30        
 Ser Phe Gly Lys Val Cys Ile Val Gln Lys Asn Asp Thr Lys Lys Met
          35                  40                  45            
 Tyr Ala Met Lys Tyr Met Asn Lys Gln Lys Cys Val Glu Arg Asn Glu
      50                  55                  60                
 Val Arg Asn Val Phe Lys Glu Leu Gln Ile Met Gln Gly Leu Glu His
  65                  70                  75                  80
 Pro Phe Leu Val Asn Leu Trp Tyr Ser Phe Gln Asp Glu Glu Asp Met
                  85                  90                  95    
 Phe Met Val Val Asp Leu Leu Leu Gly Gly Asp Leu Arg Tyr His Leu
             100                 105                 110        
 Gln Gln Asn Val His Phe Lys Glu Glu Thr Val Lys Leu Phe Ile Cys
         115                 120                 125            
 Glu Leu Val Met Ala Leu Asp Tyr Leu Gln Asn Gln Arg Ile Ile His
     130                 135                 140                
 Arg Ser Val Lys Ser Lys Glu Met Ala Met Asn Leu Leu Leu Ser Ala
 145                 150                 155                 160
 Arg Ser Gln Lys Gly Leu Phe Val Leu Lys Cys Leu Leu Thr Met Val
                 165                 170                 175    
 Lys Met Leu Ser Met Ala Ala Ala Leu Arg Gly Ala Arg Asp Thr Tyr
             180                 185                 190        
 Ala Trp Pro Pro Ala Ser Gly Thr His Arg Arg Lys Trp Tyr Met Trp
         195                 200                 205            
 Asn Gly Gln Thr Glu Asn Ser Leu Lys Leu Glu Ala Lys Leu Cys Glu
     210                 215                 220                
 Lys Asp Lys Tyr Phe Arg Glu Asp Ser Val Glu Ser Gln Asn Lys Phe
 225                 230                 235                 240
 His Glu Ser Ser Tyr Arg Lys Gln Pro Lys Thr Arg Ser
                 245                 250            



      <210> 1026
      <211> 263
      <212> PRT
      <213> Homo sapiens


      <400> 1026
 Met Thr Ile Met Glu Val Ser Leu Leu Thr Gly Phe Tyr Pro Asn Gln
   1               5                  10                  15    
 Asp Asp Leu Lys Gln Leu Thr Ser Asp Val Glu Arg Tyr Ala Phe Gln
              20                  25                  30        
 Tyr Lys Thr Lys Thr Ser Thr Ser Asp Ser Thr Val Val Leu Tyr Leu
          35                  40                  45            
 Glu Lys Leu Ser His Glu Lys Asn Thr Val Leu Gly Phe Arg Val His
      50                  55                  60                
 Arg Met Leu Gln Ala Glu Phe Leu Gln Ala Ala Leu Val Thr Ile Tyr
  65                  70                  75                  80
 Asp Tyr Tyr Glu Pro Ser Arg Arg Cys Ser Thr Phe Tyr Asn Leu Pro
                  85                  90                  95    
 Thr Glu Gln Ser Ser Leu Arg Lys Ile Cys His Lys Asp Ile Cys Arg
             100                 105                 110        
 Cys Ala Glu Gly Gln Cys Pro Ser Leu Gln Lys Pro Ser Gly Gln Leu
         115                 120                 125            
 Arg Gln Glu Glu Leu Gln Thr Thr Ala Cys Glu Ala Gly Val Asp Phe
     130                 135                 140                
 Val Tyr Lys Thr Lys Leu Glu Ser Val Glu Val Ser Ala Ser Asn Pro
 145                 150                 155                 160
 Tyr Val Tyr Tyr Asn Thr Gln Leu Glu Asp Ile Ile Lys Ser Gly Thr
                 165                 170                 175    
 Asp Pro Ala Thr Pro Leu Ala Met Lys Lys Phe Val Ser His Ala Thr
             180                 185                 190        
 Cys His Asp Ser Leu Gly Leu Gln Glu Gln Glu Ser Tyr Leu Ile Met
         195                 200                 205            
 Gly Gln Thr Ser Asp Leu Trp Arg Ile Lys Ser Asp Tyr Ser Tyr Val
     210                 215                 220                
 Leu Gly Lys Glu Thr Phe Leu Ile Leu Trp Pro Ala Asp Gly Asp Ala
 225                 230                 235                 240
 Ser Lys Lys Glu Leu Arg Asp Gln Leu Glu Glu Phe Leu Glu Tyr Met
                 245                 250                 255    
 Arg Thr His Gly Cys Gln Ser
             260            



      <210> 1027
      <211> 739
      <212> PRT
      <213> Homo sapiens


      <400> 1027
 Met Pro Ser Ala Cys Thr His Gly Pro Gly Leu Met Thr Cys Pro Trp
   1               5                  10                  15    
 Arg Thr Ser Pro Cys Ile Arg Cys Gly Cys Cys Arg Arg Leu Leu Ser
              20                  25                  30        
 Ser Lys His Ala Ser Gly Phe Leu Gly Glu His Ser Pro Gly Gly Gln
          35                  40                  45            
 Arg Ser Cys Arg Gly Gly Leu Ser Leu Glu Arg Leu Pro Asn Ser Ile
      50                  55                  60                
 Ala Ser Arg Phe Arg Leu Thr Glu Arg Glu Glu Glu Val Ile Thr Cys
  65                  70                  75                  80
 Phe Glu Arg Ala Ser Trp Ile Ala Gln Val Phe Leu Gln Glu Leu Glu
                  85                  90                  95    
 Lys Thr Thr Asn Asn Ser Thr Ser Arg His Leu Lys Gly Cys His Pro
             100                 105                 110        
 Leu Asp Tyr Glu Leu Thr Tyr Phe Leu Glu Ala Ala Leu Gln Ser Ala
         115                 120                 125            
 Tyr Val Lys Asn Leu Lys Lys Gly Asn Ile Val Lys Gly Met Arg Glu
     130                 135                 140                
 Leu Arg Glu Val Leu Arg Thr Val Glu Thr Lys Ala Thr Gln Asn Phe
 145                 150                 155                 160
 Lys Val Met Ala Ala Lys His Leu Ala Gly Val Leu Leu His Ser Leu
                 165                 170                 175    
 Ser Glu Glu Cys Tyr Trp Ser Pro Leu Ser His Pro Leu Pro Glu Phe
             180                 185                 190        
 Met Gly Lys Glu Glu Ser Ser Phe Ala Thr Gln Ala Leu Arg Lys Pro
         195                 200                 205            
 His Leu Tyr Glu Gly Asp Asn Leu Tyr Cys Pro Lys Asp Asn Ile Glu
     210                 215                 220                
 Glu Ala Leu Leu Leu Leu Leu Ile Ser Glu Ser Met Ala Thr Arg Asp
 225                 230                 235                 240
 Val Val Leu Ser Arg Val Pro Glu Gln Glu Glu Asp Arg Thr Val Ser
                 245                 250                 255    
 Leu Gln Asn Ala Ala Ala Ile Tyr Asp Leu Leu Ser Ile Thr Leu Gly
             260                 265                 270        
 Arg Arg Gly Gln Tyr Val Met Leu Ser Glu Cys Leu Glu Arg Ala Met
         275                 280                 285            
 Lys Phe Ala Phe Gly Glu Phe His Leu Trp Tyr Gln Val Ala Leu Ser
     290                 295                 300                
 Met Val Ala Cys Gly Lys Ser Ala Tyr Ala Val Ser Leu Leu Arg Glu
 305                 310                 315                 320
 Cys Val Lys Leu Arg Pro Ser Asp Pro Thr Val Pro Leu Met Ala Ala
                 325                 330                 335    
 Lys Val Cys Ile Gly Ser Leu Arg Trp Leu Glu Glu Ala Glu His Phe
             340                 345                 350        
 Ala Met Met Val Ile Ser Leu Gly Glu Glu Ala Gly Glu Phe Leu Pro
         355                 360                 365            
 Lys Gly Tyr Leu Ala Leu Gly Leu Thr Tyr Ser Leu Gln Ala Thr Asp
     370                 375                 380                
 Ala Thr Leu Lys Ser Lys Gln Asp Glu Leu His Arg Lys Ala Leu Gln
 385                 390                 395                 400
 Thr Leu Glu Arg Ala Gln Gln Leu Ala Pro Ser Asp Pro Gln Val Ile
                 405                 410                 415    
 Leu Tyr Val Ser Leu Gln Leu Ala Leu Val Arg Gln Ile Ser Ser Ala
             420                 425                 430        
 Met Glu Gln Leu Gln Glu Ala Leu Lys Val Arg Lys Asp Asp Ala His
         435                 440                 445            
 Ala Leu His Leu Leu Ala Leu Leu Phe Ser Ala Gln Lys His His Gln
     450                 455                 460                
 His Ala Leu Asp Val Val Asn Met Ala Ile Thr Glu His Pro Glu Asn
 465                 470                 475                 480
 Phe Asn Leu Met Phe Thr Lys Val Lys Leu Glu Gln Val Leu Lys Gly
                 485                 490                 495    
 Pro Glu Glu Ala Leu Val Thr Cys Arg Gln Val Leu Arg Leu Trp Gln
             500                 505                 510        
 Thr Leu Tyr Ser Phe Ser Gln Leu Gly Gly Leu Glu Lys Asp Gly Ser
         515                 520                 525            
 Phe Gly Glu Gly Leu Thr Met Lys Lys Gln Ser Gly Met His Leu Thr
     530                 535                 540                
 Leu Pro Asp Ala His Asp Ala Asp Ser Gly Ser Arg Arg Ala Ser Ser
 545                 550                 555                 560
 Ile Ala Ala Ser Arg Leu Glu Glu Ala Met Ser Glu Leu Thr Met Pro
                 565                 570                 575    
 Ser Ser Val Leu Lys Gln Gly Pro Met Gln Leu Trp Thr Thr Leu Glu
             580                 585                 590        
 Gln Ile Trp Leu Gln Ala Ala Glu Leu Phe Met Glu Gln Gln His Leu
         595                 600                 605            
 Lys Glu Ala Gly Phe Cys Ile Gln Glu Ala Ala Gly Leu Phe Pro Thr
     610                 615                 620                
 Ser His Ser Val Leu Tyr Met Arg Gly Arg Leu Ala Glu Val Lys Gly
 625                 630                 635                 640
 Asn Leu Glu Glu Ala Lys Gln Leu Tyr Lys Glu Ala Leu Thr Val Asn
                 645                 650                 655    
 Pro Asp Gly Val Arg Ile Met His Ser Leu Gly Leu Met Leu Ser Arg
             660                 665                 670        
 Leu Gly His Lys Ser Leu Ala Gln Lys Val Leu Arg Asp Ala Val Glu
         675                 680                 685            
 Arg Gln Ser Thr Cys His Glu Ala Trp Gln Gly Leu Gly Glu Val Leu
     690                 695                 700                
 Gln Ala Gln Gly Gln Asn Glu Ala Ala Val Asp Cys Phe Leu Thr Ala
 705                 710                 715                 720
 Leu Glu Leu Glu Ala Ser Ser Pro Val Leu Pro Phe Ser Ile Ile Pro
                 725                 730                 735    
 Arg Glu Leu
            



      <210> 1028
      <211> 59
      <212> PRT
      <213> Homo sapiens


      <400> 1028
 Met Gln Asn Asp Ala Gly Glu Phe Val Asp Leu Tyr Val Pro Arg Lys
   1               5                  10                  15    
 Cys Ser Ala Ser Asn Arg Ile Ile Gly Ala Lys Asp His Ala Ser Ile
              20                  25                  30        
 Gln Met Asn Val Ala Glu Gly Glu Ser Asp Asp Ser Ile Leu Arg Leu
          35                  40                  45            
 Ala Lys Ala Asp Gly Ile Val Ser Lys Asn Phe
      50                  55                



      <210> 1029
      <211> 2199
      <212> PRT
      <213> Homo sapiens


      <400> 1029
 Met Val Ile Arg Cys Leu Pro Gln Arg Glu Leu Asp Cys Asp Arg Gly
   1               5                  10                  15    
 Asn Trp Thr Ala Thr Ser Ala Glu Leu Thr Gly Ile Lys Trp Arg Arg
              20                  25                  30        
 Tyr Asn Phe Gly Gly His Gly Asp Cys Gly Pro Ile Ile Ser Ala Pro
          35                  40                  45            
 Ala Gln Asp Asp Pro Ile Leu Leu Ser Phe Ile Arg Cys Leu Gln Ala
      50                  55                  60                
 Asn Leu Leu Cys Val Trp Arg Arg Asp Val Lys Pro Asp Cys Lys Glu
  65                  70                  75                  80
 Leu Trp Ile Phe Trp Trp Gly Asp Glu Pro Asn Leu Val Gly Val Ile
                  85                  90                  95    
 His His Glu Leu Gln Val Val Glu Glu Gly Leu Trp Glu Asn Gly Leu
             100                 105                 110        
 Ser Tyr Glu Cys Arg Thr Leu Leu Phe Lys Ala Ile His Asn Leu Leu
         115                 120                 125            
 Glu Arg Cys Leu Met Asp Lys Asn Phe Val Arg Ile Gly Lys Trp Phe
     130                 135                 140                
 Val Arg Pro Tyr Glu Lys Asp Glu Lys Pro Val Asn Lys Ser Glu His
 145                 150                 155                 160
 Leu Ser Cys Ala Phe Thr Phe Phe Leu His Gly Glu Ser Asn Val Cys
                 165                 170                 175    
 Thr Ser Val Glu Ile Ala Gln His Gln Pro Ile Tyr Leu Ile Asn Glu
             180                 185                 190        
 Glu His Ile His Met Ala Gln Ser Ser Pro Ala Pro Phe Gln Val Leu
         195                 200                 205            
 Val Ser Pro Tyr Gly Leu Asn Gly Thr Leu Thr Gly Gln Ala Tyr Lys
     210                 215                 220                
 Met Ser Asp Pro Ala Thr Arg Lys Leu Ile Glu Glu Trp Gln Tyr Phe
 225                 230                 235                 240
 Tyr Pro Met Val Leu Lys Lys Lys Glu Glu Ser Lys Glu Glu Asp Glu
                 245                 250                 255    
 Leu Gly Tyr Asp Asp Asp Phe Pro Val Ala Val Glu Val Ile Val Ala
             260                 265                 270        
 Phe Val Leu Ile Ser Gln Asn Asp Ile Pro Val Pro Gln Ser Val Ala
         275                 280                 285            
 Ser Ala Gly Gly His Ile Ala Val Gly Gln Gln Gly Leu Gly Ser Val
     290                 295                 300                
 Lys Asp Pro Ser Asn Cys Gly Met Pro Leu Thr Pro Pro Thr Ser Pro
 305                 310                 315                 320
 Glu Gln Ala Ile Leu Gly Glu Ser Gly Gly Met Gln Ser Ala Ala Ser
                 325                 330                 335    
 His Leu Val Ser Gln Asp Gly Gly Met Ile Thr Met His Ser Pro Lys
             340                 345                 350        
 Arg Ser Gly Lys Ile Pro Pro Lys Leu His Asn His Met Val His Arg
         355                 360                 365            
 Val Trp Lys Glu Cys Ile Leu Asn Arg Thr Gln Ser Lys Arg Ser Gln
     370                 375                 380                
 Met Ser Thr Pro Thr Leu Glu Glu Glu Pro Ala Ser Asn Pro Ala Thr
 385                 390                 395                 400
 Trp Asp Phe Val Asp Pro Thr Gln Arg Val Ser Cys Ser Cys Ser Arg
                 405                 410                 415    
 His Lys Leu Leu Lys Arg Cys Ala Val Gly Pro Asn Arg Pro Pro Thr
             420                 425                 430        
 Val Ser Gln Pro Gly Phe Ser Ala Gly Pro Ser Ser Ser Ser Ser Leu
         435                 440                 445            
 Pro Pro Pro Ala Ser Ser Lys His Lys Thr Ala Glu Arg Gln Glu Lys
     450                 455                 460                
 Gly Asp Lys Leu Gln Lys Arg Pro Leu Ile Pro Phe His His Arg Pro
 465                 470                 475                 480
 Ser Val Ala Glu Glu Leu Cys Met Glu Gln Asp Thr Pro Gly Gln Lys
                 485                 490                 495    
 Leu Gly Leu Ala Gly Ile Asp Ser Ser Leu Glu Val Ser Ser Ser Arg
             500                 505                 510        
 Lys Tyr Asp Lys Gln Met Ala Val Pro Ser Arg Asn Thr Ser Lys Gln
         515                 520                 525            
 Met Asn Leu Asn Pro Met Asp Ser Pro His Ser Pro Ile Ser Pro Leu
     530                 535                 540                
 Pro Pro Thr Leu Ser Pro Gln Pro Arg Gly Gln Glu Thr Glu Ser Leu
 545                 550                 555                 560
 Asp Pro Pro Ser Val Pro Val Asn Pro Ala Leu Tyr Gly Asn Gly Leu
                 565                 570                 575    
 Glu Leu Gln Gln Leu Ser Thr Leu Asp Asp Arg Thr Val Leu Val Gly
             580                 585                 590        
 Gln Arg Leu Pro Leu Met Ala Glu Val Ser Glu Thr Ala Leu Tyr Cys
         595                 600                 605            
 Gly Ile Arg Pro Ser Asn Pro Glu Ser Ser Glu Lys Trp Trp His Ser
     610                 615                 620                
 Tyr Arg Leu Pro Pro Ser Asp Asp Ala Glu Phe Arg Pro Pro Glu Leu
 625                 630                 635                 640
 Gln Gly Glu Arg Cys Asp Ala Lys Met Glu Val Asn Ser Glu Ser Thr
                 645                 650                 655    
 Ala Leu Gln Arg Leu Leu Ala Gln Pro Asn Lys Arg Phe Lys Ile Trp
             660                 665                 670        
 Gln Asp Lys Gln Pro Gln Leu Gln Pro Leu His Phe Leu Asp Pro Leu
         675                 680                 685            
 Pro Leu Ser Gln Gln Pro Gly Asp Ser Leu Gly Glu Val Asn Asp Pro
     690                 695                 700                
 Tyr Thr Phe Glu Asp Gly Asp Ile Lys Tyr Ile Phe Thr Ala Asn Lys
 705                 710                 715                 720
 Lys Cys Lys Gln Gly Thr Glu Lys Asp Ser Leu Lys Lys Asn Lys Ser
                 725                 730                 735    
 Glu Asp Gly Phe Gly Thr Lys Asp Val Thr Thr Pro Gly His Ser Thr
             740                 745                 750        
 Pro Val Pro Asp Gly Lys Asn Ala Met Ser Ile Phe Ser Ser Ala Thr
         755                 760                 765            
 Lys Thr Asp Val Arg Gln Asp Asn Ala Ala Gly Arg Ala Gly Ser Ser
     770                 775                 780                
 Ser Leu Thr Gln Val Thr Asp Leu Ala Pro Ser Leu His Asp Leu Asp
 785                 790                 795                 800
 Asn Ile Phe Asp Asn Ser Asp Asp Asp Glu Leu Gly Ala Val Ser Pro
                 805                 810                 815    
 Ala Leu Arg Ser Ser Lys Met Pro Ala Val Gly Thr Glu Asp Arg Pro
             820                 825                 830        
 Leu Gly Lys Asp Gly Arg Ala Ala Val Pro Tyr Pro Pro Thr Val Ala
         835                 840                 845            
 Asp Leu Gln Arg Met Phe Pro Thr Pro Pro Ser Leu Glu Gln His Pro
     850                 855                 860                
 Ala Phe Ser Pro Val Met Asn Tyr Lys Asp Gly Ile Ser Ser Glu Thr
 865                 870                 875                 880
 Val Thr Ala Leu Gly Met Met Glu Ser Pro Met Val Ser Met Val Ser
                 885                 890                 895    
 Thr Gln Leu Thr Glu Phe Lys Met Glu Val Glu Asp Gly Leu Gly Ser
             900                 905                 910        
 Pro Lys Pro Glu Glu Ile Lys Asp Phe Ser Tyr Val His Lys Val Pro
         915                 920                 925            
 Ser Phe Gln Pro Phe Val Gly Ser Ser Met Phe Ala Pro Leu Lys Met
     930                 935                 940                
 Leu Pro Ser His Cys Leu Leu Pro Leu Lys Ile Pro Asp Ala Cys Leu
 945                 950                 955                 960
 Phe Arg Pro Ser Trp Ala Ile Pro Pro Lys Ile Glu Gln Leu Pro Met
                 965                 970                 975    
 Pro Pro Ala Ala Thr Phe Ile Arg Asp Gly Tyr Asn Asn Val Pro Ser
             980                 985                 990        
 Val Gly Ser Leu Ala Asp Pro Asp Tyr Leu Asn Thr Pro Gln Met Asn
         995                1000                1005            
 Thr Pro Val Thr Leu Asn Ser Ala Ala Pro Ala Ser Asn Ser Gly Ala
    1010                1015                1020                
 Gly Val Leu Pro Ser Pro Ala Thr Pro Arg Phe Ser Val Pro Thr Pro
1025                1030                1035                1040
 Arg Thr Pro Arg Thr Pro Arg Thr Pro Arg Gly Gly Gly Thr Ala Ser
                1045                1050                1055    
 Gly Gln Gly Ser Val Lys Tyr Asp Ser Thr Asp Gln Gly Ser Pro Ala
            1060                1065                1070        
 Ser Thr Pro Ser Thr Thr Arg Pro Leu Asn Ser Val Glu Pro Ala Thr
        1075                1080                1085            
 Met Gln Pro Ile Pro Glu Ala His Ser Leu Tyr Val Thr Leu Ile Leu
    1090                1095                1100                
 Ser Asp Ser Val Met Asn Ile Phe Lys Asp Arg Asn Phe Asp Ser Cys
1105                1110                1115                1120
 Cys Ile Cys Ala Cys Asn Met Asn Ile Lys Gly Ala Asp Val Gly Leu
                1125                1130                1135    
 Tyr Ile Pro Asp Ser Ser Asn Glu Asp Gln Tyr Arg Cys Thr Cys Gly
            1140                1145                1150        
 Phe Ser Ala Ile Met Asn Arg Lys Leu Gly Tyr Asn Ser Gly Leu Phe
        1155                1160                1165            
 Leu Glu Asp Glu Leu Asp Ile Phe Gly Lys Asn Ser Asp Ile Gly Gln
    1170                1175                1180                
 Ala Ala Glu Arg Arg Leu Met Met Cys Gln Ser Thr Phe Leu Pro Gln
1185                1190                1195                1200
 Val Glu Gly Thr Lys Lys Pro Gln Glu Pro Pro Ile Ser Leu Leu Leu
                1205                1210                1215    
 Leu Leu Gln Asn Gln His Thr Gln Pro Phe Ala Ser Leu Asn Phe Leu
            1220                1225                1230        
 Asp Tyr Ile Ser Ser Asn Asn Arg Gln Thr Leu Pro Cys Val Ser Trp
        1235                1240                1245            
 Ser Tyr Asp Arg Val Gln Ala Asp Asn Asn Asp Tyr Trp Thr Glu Cys
    1250                1255                1260                
 Phe Asn Ala Leu Glu Gln Gly Arg Gln Tyr Val Asp Asn Pro Thr Gly
1265                1270                1275                1280
 Gly Lys Val Asp Glu Ala Leu Val Arg Ser Ala Thr Val His Ser Trp
                1285                1290                1295    
 Pro His Ser Asn Val Leu Asp Ile Ser Met Leu Ser Ser Gln Asp Val
            1300                1305                1310        
 Val Arg Met Leu Leu Ser Leu Gln Pro Phe Leu Gln Asp Ala Ile Gln
        1315                1320                1325            
 Lys Lys Arg Thr Gly Arg Thr Trp Glu Asn Ile Gln His Val Gln Gly
    1330                1335                1340                
 Pro Leu Thr Trp Gln Gln Phe His Lys Met Ala Gly Arg Gly Thr Tyr
1345                1350                1355                1360
 Gly Ser Glu Glu Ser Pro Glu Pro Leu Pro Ile Pro Thr Leu Leu Val
                1365                1370                1375    
 Gly Tyr Asp Lys Asp Phe Leu Thr Ile Ser Pro Phe Ser Leu Pro Phe
            1380                1385                1390        
 Trp Glu Arg Leu Leu Leu Asp Pro Tyr Gly Gly His Arg Asp Val Ala
        1395                1400                1405            
 Tyr Ile Val Val Cys Pro Glu Asn Glu Ala Leu Leu Glu Gly Ala Lys
    1410                1415                1420                
 Thr Phe Phe Arg Asp Leu Ser Ala Val Tyr Glu Met Cys Arg Leu Gly
1425                1430                1435                1440
 Gln His Lys Pro Ile Cys Lys Val Leu Arg Asp Gly Ile Met Arg Val
                1445                1450                1455    
 Gly Lys Thr Val Ala Gln Lys Leu Thr Asp Glu Leu Val Ser Glu Trp
            1460                1465                1470        
 Phe Asn Gln Pro Trp Ser Gly Glu Glu Asn Asp Asn His Ser Arg Leu
        1475                1480                1485            
 Lys Leu Tyr Ala Gln Val Cys Arg His His Leu Ala Pro Tyr Leu Ala
    1490                1495                1500                
 Thr Leu Gln Leu Asp Ser Ser Leu Leu Ile Pro Pro Lys Tyr Gln Thr
1505                1510                1515                1520
 Pro Pro Ala Ala Ala Gln Gly Gln Ala Thr Pro Gly Asn Ala Gly Pro
                1525                1530                1535    
 Leu Ala Pro Asn Gly Ser Ala Ala Pro Pro Ala Gly Ser Ala Phe Asn
            1540                1545                1550        
 Pro Thr Ser Asn Ser Ser Ser Thr Asn Pro Ala Ala Ser Ser Ser Ala
        1555                1560                1565            
 Ser Gly Ser Ser Val Pro Pro Val Ser Ser Ser Ala Ser Ala Pro Gly
    1570                1575                1580                
 Ile Ser Gln Ile Ser Thr Thr Ser Ser Ser Gly Phe Ser Gly Ser Val
1585                1590                1595                1600
 Gly Gly Gln Asn Pro Ser Thr Gly Gly Ile Ser Ala Asp Arg Thr Gln
                1605                1610                1615    
 Gly Asn Ile Gly Cys Gly Gly Asp Thr Asp Pro Gly Gln Ser Ser Ser
            1620                1625                1630        
 Gln Pro Ser Gln Asp Gly Gln Glu Ser Val Thr Glu Arg Glu Arg Ile
        1635                1640                1645            
 Gly Ile Pro Thr Glu Pro Asp Ser Ala Asp Ser His Ala His Pro Pro
    1650                1655                1660                
 Ala Val Val Ile Tyr Met Val Asp Pro Phe Thr Tyr Ala Ala Glu Glu
1665                1670                1675                1680
 Asp Ser Thr Ser Gly Asn Phe Trp Leu Leu Ser Leu Met Arg Cys Tyr
                1685                1690                1695    
 Thr Glu Met Leu Asp Asn Leu Pro Glu His Met Arg Asn Ser Phe Ile
            1700                1705                1710        
 Leu Gln Ile Val Pro Cys Gln Tyr Met Leu Gln Thr Met Lys Asp Glu
        1715                1720                1725            
 Gln Val Phe Tyr Ile Gln Tyr Leu Lys Ser Met Ala Phe Ser Val Tyr
    1730                1735                1740                
 Cys Gln Cys Arg Arg Pro Leu Pro Thr Gln Ile His Ile Lys Ser Leu
1745                1750                1755                1760
 Thr Gly Phe Gly Pro Ala Ala Ser Ile Glu Met Thr Leu Lys Asn Pro
                1765                1770                1775    
 Glu Arg Pro Ser Pro Ile Gln Leu Tyr Ser Pro Pro Phe Ile Leu Ala
            1780                1785                1790        
 Pro Ile Lys Asp Lys Gln Thr Glu Leu Gly Glu Thr Phe Gly Glu Ala
        1795                1800                1805            
 Ser Gln Lys Tyr Asn Val Leu Phe Val Gly Tyr Cys Leu Ser His Asp
    1810                1815                1820                
 Gln Arg Trp Leu Leu Ala Ser Cys Thr Asp Leu His Gly Glu Leu Leu
1825                1830                1835                1840
 Glu Thr Cys Val Val Asn Ile Ala Leu Pro Asn Arg Ser Arg Arg Ser
                1845                1850                1855    
 Lys Val Ser Ala Arg Lys Ile Gly Leu Gln Lys Leu Trp Glu Trp Cys
            1860                1865                1870        
 Ile Gly Ile Val Gln Met Thr Ser Leu Pro Trp Arg Val Val Ile Gly
        1875                1880                1885            
 Arg Leu Gly Arg Leu Gly His Gly Glu Leu Lys Asp Trp Ser Ile Leu
    1890                1895                1900                
 Leu Gly Glu Cys Ser Leu Gln Thr Ile Ser Lys Lys Leu Lys Asp Val
1905                1910                1915                1920
 Cys Arg Met Cys Gly Ile Ser Ala Ala Asp Ser Pro Ser Ile Leu Ser
                1925                1930                1935    
 Ala Cys Leu Val Ala Met Glu Pro Gln Gly Ser Phe Val Val Met Pro
            1940                1945                1950        
 Asp Ala Val Thr Met Gly Ser Val Phe Gly Arg Ser Thr Ala Leu Asn
        1955                1960                1965            
 Met Gln Ser Ser Gln Leu Asn Thr Pro Gln Asp Ala Ser Cys Thr His
    1970                1975                1980                
 Ile Leu Val Phe Pro Thr Ser Ser Thr Ile Gln Val Ala Pro Ala Asn
1985                1990                1995                2000
 Tyr Pro Asn Glu Asp Gly Phe Ser Pro Asn Asn Asp Asp Met Phe Val
                2005                2010                2015    
 Asp Leu Pro Phe Pro Asp Asp Met Asp Asn Asp Ile Gly Ile Leu Met
            2020                2025                2030        
 Thr Gly Asn Leu His Ser Ser Pro Asn Ser Ser Pro Val Pro Ser Pro
        2035                2040                2045            
 Gly Ser Pro Ser Gly Ile Gly Val Gly Ser His Phe Gln His Ser Arg
    2050                2055                2060                
 Ser Gln Gly Glu Arg Leu Leu Ser Arg Glu Ala Pro Glu Glu Leu Lys
2065                2070                2075                2080
 Gln Gln Pro Leu Ala Leu Gly Tyr Phe Val Ser Thr Ala Lys Ala Glu
                2085                2090                2095    
 Asn Leu Pro Gln Trp Phe Trp Ser Ser Cys Pro Gln Ala Gln Asn Gln
            2100                2105                2110        
 Cys Pro Leu Phe Leu Lys Ala Ser Leu His His His Ile Ser Val Ala
        2115                2120                2125            
 Gln Thr Asp Glu Leu Leu Pro Ala Arg Asn Ser Gln Arg Val Pro His
    2130                2135                2140                
 Pro Leu Asp Ser Lys Thr Thr Ser Asp Val Leu Arg Phe Val Leu Glu
2145                2150                2155                2160
 Gln Tyr Asn Ala Leu Ser Trp Leu Thr Cys Asn Pro Ala Thr Gln Asp
                2165                2170                2175    
 Arg Thr Ser Cys Leu Pro Val His Phe Val Val Leu Thr Gln Leu Tyr
            2180                2185                2190        
 Asn Ala Ile Met Asn Ile Leu
        2195                



      <210> 1030
      <211> 88
      <212> PRT
      <213> Homo sapiens


      <400> 1030
 Met Ile Thr Cys Leu Leu Thr Gly Met Gly Lys Asn Ala His Lys Ala
   1               5                  10                  15    
 Val Asn Ser Glu Lys Leu Arg Glu Ile Thr Gln Glu Pro Gln Lys Asn
              20                  25                  30        
 Pro Ala Leu Phe Leu Ser Cys Ile Thr Glu Ala Met Leu Lys Tyr Thr
          35                  40                  45            
 Asn Leu Asp Pro Glu Ser Arg Glu Gly Gln Thr Phe Leu His Leu Gln
      50                  55                  60                
 Phe Ile Ser Gln Ser Ser Pro Asp Ile Arg Lys Ile Ile Thr Lys Leu
  65                  70                  75                  80
 Arg Gly Arg Thr Asn Phe Arg His
                  85            



      <210> 1031
      <211> 612
      <212> PRT
      <213> Homo sapiens


      <400> 1031
 Met Asp Ser Glu Tyr Tyr Ser Gly Asp Gln Ser Asp Asp Gly Gly Ala
   1               5                  10                  15    
 Thr Pro Val Gln Asp Glu Arg Asp Ser Gly Ser Asp Gly Glu Asp Asp
              20                  25                  30        
 Val Asn Glu Gln His Ser Gly Ser Asp Thr Gly Ser Val Glu Arg His
          35                  40                  45            
 Ser Glu Asn Glu Thr Ser Asp Ser Glu Asn Glu Glu Leu Pro Lys Pro
      50                  55                  60                
 Arg Ile Ser Asp Ser Glu Ser Glu Asp Pro Pro Arg Asn Gln Ala Ser
  65                  70                  75                  80
 Asp Ser Glu Asn Glu Glu Leu Pro Lys Pro Arg Val Ser Asp Ser Glu
                  85                  90                  95    
 Ser Glu Gly Pro Gln Lys Gly Pro Ala Ser Asp Ser Glu Thr Glu Asp
             100                 105                 110        
 Ala Ser Arg His Lys Gln Lys Pro Glu Ser Asp Asp Asp Ser Asp Arg
         115                 120                 125            
 Glu Asn Lys Gly Glu Asp Thr Glu Met Gln Asn Asp Ser Phe His Ser
     130                 135                 140                
 Asp Ser His Met Asp Arg Lys Lys Phe His Ser Ser Asp Ser Glu Glu
 145                 150                 155                 160
 Glu Glu His Lys Lys Gln Lys Met Asp Ser Asp Glu Asp Glu Lys Glu
                 165                 170                 175    
 Gly Glu Glu Glu Lys Val Ala Lys Arg Lys Ala Ala Val Leu Ser Asp
             180                 185                 190        
 Ser Glu Asp Glu Glu Lys Ala Ser Ala Lys Lys Ser Arg Val Val Ser
         195                 200                 205            
 Asp Ala Asp Asp Ser Asp Ser Asp Ala Val Ser Asp Lys Ser Gly Lys
     210                 215                 220                
 Arg Glu Lys Thr Ile Ala Ser Asp Ser Glu Glu Glu Ala Gly Lys Glu
 225                 230                 235                 240
 Leu Ser Asp Lys Lys Asn Glu Glu Lys Asp Leu Phe Gly Ser Asp Ser
                 245                 250                 255    
 Glu Ser Gly Asn Glu Glu Glu Asn Leu Ile Ala Asp Ile Phe Gly Glu
             260                 265                 270        
 Ser Gly Asp Glu Glu Glu Glu Glu Phe Thr Gly Phe Asn Gln Glu Asp
         275                 280                 285            
 Leu Glu Glu Glu Lys Gly Glu Thr Gln Val Lys Glu Ala Glu Asp Ser
     290                 295                 300                
 Asp Ser Asp Asp Asn Ile Lys Arg Gly Lys His Met Asp Phe Leu Ser
 305                 310                 315                 320
 Asp Phe Glu Met Met Leu Gln Arg Lys Lys Ser Met Ser Gly Lys Arg
                 325                 330                 335    
 Arg Arg Asn Arg Asp Gly Gly Thr Phe Ile Ser Asp Ala Asp Asp Val
             340                 345                 350        
 Val Ser Ala Met Ile Val Lys Met Asn Glu Ala Ala Glu Glu Asp Arg
         355                 360                 365            
 Gln Leu Asn Asn Gln Lys Lys Pro Ala Leu Lys Lys Leu Thr Leu Leu
     370                 375                 380                
 Pro Ala Val Val Met His Leu Lys Lys Gln Asp Leu Lys Glu Thr Phe
 385                 390                 395                 400
 Ile Asp Ser Gly Val Met Ser Ala Ile Lys Glu Trp Leu Ser Pro Leu
                 405                 410                 415    
 Pro Asp Arg Ser Leu Pro Ala Leu Lys Ile Arg Glu Glu Leu Leu Lys
             420                 425                 430        
 Ile Leu Gln Glu Leu Pro Ser Val Ser Gln Glu Thr Leu Lys His Ser
         435                 440                 445            
 Gly Ile Gly Arg Ala Val Met Tyr Leu Tyr Lys His Pro Lys Glu Ser
     450                 455                 460                
 Arg Ser Asn Lys Asp Met Ala Gly Lys Leu Ile Asn Glu Trp Ser Arg
 465                 470                 475                 480
 Pro Ile Phe Gly Leu Thr Ser Asn Tyr Lys Gly Met Thr Arg Glu Glu
                 485                 490                 495    
 Arg Glu Gln Arg Asp Leu Glu Gln Met Pro Gln Arg Arg Arg Met Asn
             500                 505                 510        
 Ser Thr Gly Gly Gln Thr Pro Arg Arg Asp Leu Glu Lys Val Leu Thr
         515                 520                 525            
 Gly Glu Glu Lys Ala Leu Arg Pro Gly Asp Pro Gly Phe Cys Ala Arg
     530                 535                 540                
 Ala Arg Val Pro Met Pro Ser Asn Lys Asp Tyr Val Val Arg Pro Lys
 545                 550                 555                 560
 Trp Asn Val Glu Met Glu Ser Ser Arg Phe Gln Ala Thr Ser Lys Lys
                 565                 570                 575    
 Gly Ile Ser Arg Leu Asp Lys Gln Met Arg Lys Phe Thr Asp Ile Arg
             580                 585                 590        
 Lys Lys Ser Arg Ser Ala His Ala Val Lys Ile Ser Ile Glu Gly Asn
         595                 600                 605            
 Lys Met Pro Leu
     610        



      <210> 1032
      <211> 84
      <212> PRT
      <213> Homo sapiens


      <400> 1032
 Met Ala Ala His Arg Thr His Met Ser Gln Pro Ile Thr Val Thr Ser
   1               5                  10                  15    
 Pro Ser Asp Pro Thr His Glu Tyr Ser His Thr His Ile His Ile His
              20                  25                  30        
 Thr His Thr His Thr Leu Ser His Ser Leu Ser Tyr Phe Tyr Thr His
          35                  40                  45            
 Ser Asn Thr His Thr Cys Cys Pro Arg Ala Lys Ala Leu Thr Pro Ala
      50                  55                  60                
 Pro Val Thr Leu Pro His His Gln Pro Gly Ser Leu Ala Ala Gly His
  65                  70                  75                  80
 Pro His Cys Val
                



      <210> 1033
      <211> 171
      <212> PRT
      <213> Homo sapiens


      <400> 1033
 Met Leu Ser Lys Lys Gln Glu Phe Leu Glu Lys Lys Ile Glu Gln Arg
   1               5                  10                  15    
 His Gly Thr Lys Asn Lys Pro Ala Ala Leu Gln Ala Leu Lys Arg Lys
              20                  25                  30        
 Lys Arg Tyr Glu Lys Gln Leu Ala Gln Ile Asp Gly Thr Leu Ser Thr
          35                  40                  45            
 Ile Glu Phe Gln Arg Glu Ala Leu Glu Asn Ala Asn Thr Asn Thr Glu
      50                  55                  60                
 Val Leu Lys Asn Met Gly Tyr Ala Ala Lys Ala Met Lys Ala Ala His
  65                  70                  75                  80
 Asp Asn Met Asp Ile Asp Lys Val Asp Glu Leu Met Gln Asp Ile Ala
                  85                  90                  95    
 Asp Gln Gln Glu Leu Ala Glu Glu Ile Ser Thr Ala Ile Ser Lys Pro
             100                 105                 110        
 Val Gly Phe Gly Glu Glu Phe Asp Glu Asp Glu Leu Met Ala Glu Leu
         115                 120                 125            
 Glu Glu Leu Glu Gln Glu Glu Leu Asp Lys Asn Leu Leu Glu Ile Ser
     130                 135                 140                
 Gly Pro Glu Thr Val Pro Leu Pro Asn Val Pro Ser Ile Ala Leu Pro
 145                 150                 155                 160
 Ser Lys Pro Ala Lys Lys Arg Lys Thr Thr Thr
                 165                 170    



      <210> 1034
      <211> 429
      <212> PRT
      <213> Homo sapiens


      <400> 1034
 Met Ala Pro Phe Ala Asp Tyr Leu Asn Ser Ile Tyr Phe Asn Arg Phe
   1               5                  10                  15    
 Leu Gln Trp Lys Trp Leu Glu Arg Gln Pro Val Thr Lys Asn Thr Phe
              20                  25                  30        
 Arg Gln Tyr Arg Val Leu Gly Lys Gly Gly Phe Gly Glu Val Cys Ala
          35                  40                  45            
 Cys Gln Val Arg Ala Thr Gly Lys Met Tyr Ala Phe Lys Lys Leu Glu
      50                  55                  60                
 Lys Lys Arg Ile Lys Lys Gln Lys Gly Glu Ala Met Ala Leu Asn Glu
  65                  70                  75                  80
 Lys Gln Ile Leu Glu Arg Val Asn Thr Gln Ala Val Phe Tyr Val Pro
                  85                  90                  95    
 Arg Ser Ala Cys Gly Leu Glu Asp Leu His Arg Glu Arg Ile Val Tyr
             100                 105                 110        
 Arg Asp Leu Lys Leu Arg Asn Ile Leu Leu Asp Asp His Gly His Ile
         115                 120                 125            
 Leu Val Ser Asp Leu Gly Leu Ala Val His Val Pro Glu Gly Gln Thr
     130                 135                 140                
 Ile Lys Gly Arg Val Gly Thr Val Ser Tyr Met Ala Pro Glu Val Val
 145                 150                 155                 160
 Lys Asn Glu Pro Tyr Thr Phe Ser Ser Asp Cys Trp Ala Leu Gly Cys
                 165                 170                 175    
 Leu Pro Gln Glu Met Ile Ala Gly Gln Ser Leu Phe Gln Gln Arg Lys
             180                 185                 190        
 Lys Lys Ile Lys Arg Glu Glu Val Glu Arg Leu Val Lys Glu Asp Pro
         195                 200                 205            
 Glu Glu Tyr Ser Glu Arg Phe Ser Pro Gln Ala Cys Ser Gln Leu Leu
     210                 215                 220                
 Cys Lys Asp Pro Ala Glu Arg Leu Gly Cys Arg Gly Gly Ser Ala Arg
 225                 230                 235                 240
 Glu Val Lys Glu His Pro Leu Leu Lys Lys Leu Asn Phe Lys Arg Val
                 245                 250                 255    
 Gly Ala Gly Met Leu Glu Pro Pro Phe Lys Pro Asp Pro Arg Ala Ile
             260                 265                 270        
 Tyr Cys Lys Asp Ile Leu Asp Ile Lys Gln Phe Ser Arg Val Lys Gly
         275                 280                 285            
 Val Glu Leu Glu Ala Thr Asp Gln Asp Phe Tyr Gln Lys Phe Ala Thr
     290                 295                 300                
 Gly Ser Val Pro Ile Pro Trp Gln Asn Gly Met Val Glu Thr Glu Cys
 305                 310                 315                 320
 Phe Gln Glu Leu Asn Val Phe Gly Leu Asp Gly Ser Val Pro Pro Asp
                 325                 330                 335    
 Leu Asp Trp Lys Gly Gln Pro Pro Ala Arg Asp Cys Cys Arg Asp Ser
             340                 345                 350        
 Ser Val Ala Lys Gly Leu Leu Trp Lys Leu Arg Gly Gln Arg Gly Arg
         355                 360                 365            
 Ala Pro Tyr Pro Pro Leu Ala Pro Ser Gln Arg Pro Pro Arg Ala Val
     370                 375                 380                
 Gly Gly Ser Ser Tyr Ser Glu Cys Leu Leu Gln Phe Cys Thr Val Asp
 385                 390                 395                 400
 Phe Pro Ile Val His Ser Ser Cys Gly Leu Gly Asn Thr Asp Gly Thr
                 405                 410                 415    
 Val Pro Ser Val Leu Cys Pro Leu Ser Pro Trp Pro Ala
             420                 425                



      <210> 1035
      <211> 159
      <212> PRT
      <213> Homo sapiens


      <400> 1035
 Met Glu Thr Gly Pro Ser Glu Glu Pro Ser Gly Arg Lys Glu Ser Gln
   1               5                  10                  15    
 Glu Met Cys Pro Pro Gly Leu Leu Val Phe Ala Gly Ser Ser Glu Gln
              20                  25                  30        
 Asp Ala Asn Leu Ala Lys Gln Phe Trp Ile Ser Ala Ser Met Tyr Pro
          35                  40                  45            
 Pro Ser Glu Ser Gln Leu Val Leu Arg Arg Asp Ser Ser Gln Arg Leu
      50                  55                  60                
 Pro Val Ala Arg Pro Arg Arg Ser Arg Gly Ser Glu Asn Ser His Ser
  65                  70                  75                  80
 Ser Gln Ser Phe His Leu Ala Ser Asn Lys Asn Arg Asp Ile Phe Ala
                  85                  90                  95    
 Glu Ala Leu Lys Ile Gln Glu Ser Glu Glu Lys Val Lys Tyr Leu Gln
             100                 105                 110        
 Lys Lys Glu Val Thr Val Asp Glu Gln Ser Ile Ala Cys Ser Pro Lys
         115                 120                 125            
 Glu Val Ile Pro Glu Lys Phe Asp Arg Arg Ser Lys Thr Leu Cys Gln
     130                 135                 140                
 Gly Leu Thr Ala Cys Lys Arg Asn Pro Ala Met Gly Ile Gly Met
 145                 150                 155                



      <210> 1036
      <211> 650
      <212> PRT
      <213> Homo sapiens


      <400> 1036
 Met Met Thr Lys Ala Val Pro Glu Glu Pro Arg Lys Pro Gly Arg Leu
   1               5                  10                  15    
 Thr Gln Ala Leu Asn Ser Pro Leu Thr Trp Glu His Val Trp Ile Cys
              20                  25                  30        
 Val Pro Gly Gly Thr Pro Asp Cys Leu Thr Asp Thr Phe Arg Val Lys
          35                  40                  45            
 Arg Pro His Leu Arg Arg Ser Ala Ser Asn Gly His Val Pro Gly Thr
      50                  55                  60                
 Pro Val Tyr Arg Glu Lys Glu Asp Met Tyr Asp Glu Ile Ile Glu Leu
  65                  70                  75                  80
 Lys Lys Ser Leu His Val Gln Lys Ser Asp Val Asp Leu Met Arg Thr
                  85                  90                  95    
 Lys Leu Arg Arg Leu Glu Glu Glu Asn Ser Arg Lys Asp Arg Gln Ile
             100                 105                 110        
 Glu Gln Leu Leu Asp Pro Ser Arg Gly Thr Asp Phe Val Arg Thr Leu
         115                 120                 125            
 Ala Glu Lys Arg Pro Asp Ala Ser Trp Val Ile Asn Gly Leu Lys Gln
     130                 135                 140                
 Arg Ile Leu Lys Leu Glu Gln Gln Cys Lys Glu Lys Asp Gly Thr Ile
 145                 150                 155                 160
 Ser Lys Leu Gln Thr Asp Met Lys Thr Thr Asn Leu Glu Glu Met Arg
                 165                 170                 175    
 Ile Ala Met Glu Thr Tyr Tyr Glu Glu Val His Arg Leu Gln Thr Leu
             180                 185                 190        
 Leu Ala Ser Ser Glu Thr Thr Gly Lys Lys Tyr Asp Gly Arg Leu Gln
         195                 200                 205            
 Ala Val Phe Cys Val Leu Pro Ser Arg Cys Gly Ser Ser Ser Glu Asn
     210                 215                 220                
 Val Trp Leu Ser Arg Gly Pro Leu Gly Glu Lys Lys Thr Gly Ala Lys
 225                 230                 235                 240
 Arg Gln Lys Lys Met Gly Ser Ala Leu Leu Ser Leu Ser Arg Ser Val
                 245                 250                 255    
 Gln Glu Leu Thr Glu Glu Asn Gln Ser Leu Lys Glu Asp Leu Asp Arg
             260                 265                 270        
 Val Leu Ser Thr Ser Pro Thr Ile Ser Lys Thr Gln Gly Tyr Val Glu
         275                 280                 285            
 Trp Ser Lys Pro Arg Leu Leu Arg Arg Ile Val Glu Leu Glu Lys Lys
     290                 295                 300                
 Leu Ser Val Met Glu Ser Ser Lys Ser His Ala Ala Glu Pro Val Arg
 305                 310                 315                 320
 Ser His Pro Pro Ala Cys Leu Ala Ser Ser Ser Ala Leu His Arg Gln
                 325                 330                 335    
 Pro Arg Gly Asp Arg Asn Lys Asp His Glu Arg Leu Arg Gly Ala Val
             340                 345                 350        
 Arg Asp Leu Lys Glu Glu Arg Thr Ala Leu Gln Glu Gln Leu Leu Gln
         355                 360                 365            
 Arg Asp Leu Glu Val Lys Gln Leu Leu Gln Ala Lys Ala Asp Leu Glu
     370                 375                 380                
 Lys Glu Leu Glu Cys Ala Arg Glu Gly Glu Glu Glu Arg Arg Glu Arg
 385                 390                 395                 400
 Glu Glu Val Leu Arg Glu Glu Ile Gln Thr Leu Thr Ser Lys Leu Gln
                 405                 410                 415    
 Glu Leu Gln Glu Met Lys Lys Glu Glu Lys Glu Asp Cys Pro Glu Val
             420                 425                 430        
 Pro His Lys Ala Gln Glu Leu Pro Ala Pro Thr Pro Ser Ser Arg His
         435                 440                 445            
 Cys Glu Gln Asp Trp Pro Pro Asp Ser Ser Glu Glu Gly Leu Pro Arg
     450                 455                 460                
 Pro Arg Ser Pro Cys Ser Asp Gly Arg Arg Asp Ala Ala Ala Arg Val
 465                 470                 475                 480
 Leu Gln Ala Gln Trp Lys Val Tyr Lys His Lys Lys Lys Lys Ala Val
                 485                 490                 495    
 Leu Asp Glu Ala Ala Val Val Leu Gln Ala Ala Phe Arg Gly His Leu
             500                 505                 510        
 Thr Arg Thr Lys Leu Leu Ala Ser Lys Ala His Gly Ser Glu Pro Pro
         515                 520                 525            
 Ser Val Pro Gly Leu Pro Asp Gln Ser Ser Pro Val Pro Arg Val Pro
     530                 535                 540                
 Ser Pro Ile Ala Gln Ala Thr Gly Ser Pro Val Gln Glu Glu Ala Ile
 545                 550                 555                 560
 Val Ile Ile Gln Ser Ala Leu Arg Ala His Leu Ala Arg Ala Arg His
                 565                 570                 575    
 Ser Ala Thr Gly Lys Arg Thr Thr Thr Ala Ala Ser Thr Arg Arg Arg
             580                 585                 590        
 Ser Ala Ser Ala Thr His Gly Asp Ala Ser Ser Pro Pro Phe Leu Ala
         595                 600                 605            
 Ala Leu Pro Asp Pro Ser Pro Ser Gly Pro Gln Ala Leu Ala Pro Leu
     610                 615                 620                
 Pro Gly Asp Asp Val Asn Ser Asp Asp Ser Asp Asp Ile Val Ile Ala
 625                 630                 635                 640
 Pro Ser Leu Pro Thr Lys Asn Phe Pro Val
                 645                 650



      <210> 1037
      <211> 335
      <212> PRT
      <213> Homo sapiens


      <400> 1037
 Met Val Lys Glu Gln Glu Ser His Leu Leu Leu Arg Phe Gln Val Ser
   1               5                  10                  15    
 Tyr Pro Glu Thr Gln Gly Ile Phe Pro Val Leu Ser Ser Met Pro Leu
              20                  25                  30        
 Phe Pro Met His Cys Ala His Ala Thr Asn Asn Ala Ala Ser Thr Gln
          35                  40                  45            
 Phe His Ser Thr Gly Ile Ser Leu Thr Ala Glu Ala Thr Asp Cys Thr
      50                  55                  60                
 Pro Thr Tyr Thr Asp Val Ile Ser Glu Thr Leu Cys Ser Met Lys Lys
  65                  70                  75                  80
 Arg Lys Asp Asn Leu Asn Gln Leu Tyr Gln His His Trp Thr Glu Trp
                  85                  90                  95    
 Asn Tyr Phe Asp Lys His Leu Lys Glu Leu Gln Asp Asn Phe Ser Arg
             100                 105                 110        
 Glu Met Lys Asn Ile Asp Pro Lys Ala Ala Asp Thr Lys Lys Ala Asn
         115                 120                 125            
 His Met Phe Ile Pro Pro Ser Ala Val Asn Glu Glu Ser Pro Asp Lys
     130                 135                 140                
 Lys Thr Lys Gly Ser Leu Gln Arg Glu Ile Glu Phe Lys Gly Cys Ser
 145                 150                 155                 160
 Asn Lys Asn His Gly Lys Gly Arg Ser Val Asn Met Arg Gly Lys Glu
                 165                 170                 175    
 Glu Arg Glu Arg Glu Glu Lys Gln Lys Leu Asn Ile Ser Phe His Ser
             180                 185                 190        
 Leu Pro Ser Pro Glu Glu Leu His Asn Leu Glu Pro Gly Ser Ala Tyr
         195                 200                 205            
 Arg Ile Arg Asp Ile Ser Ala Thr Arg Thr Pro Leu Arg Arg Pro Ser
     210                 215                 220                
 Ser Trp Glu Pro Ser Leu Ile Tyr Gln Glu Gln Gly Val Ile Ile Val
 225                 230                 235                 240
 Val Pro His Gly Val Cys Val Arg Ser Gly Cys Met Asn Leu Trp Glu
                 245                 250                 255    
 Ala Leu Arg Thr Val Pro Asp Thr Cys Phe Tyr His Tyr Phe Met Val
             260                 265                 270        
 Tyr Ser Tyr Leu Leu Lys Lys Met Leu Thr Val Lys Gln Pro Gln Val
         275                 280                 285            
 Gly Pro Ser Gly Gly Ile Pro Glu Glu Gly Ile Val Ile Ile Gly Asp
     290                 295                 300                
 Asp Cys Cys Met His Val Ile Ala Ala Glu Thr Phe Gln Trp Asp Lys
 305                 310                 315                 320
 Asp Val Glu Val Glu Asp Ser Asp Ile Asn Asp Pro Asp Pro Val
                 325                 330                 335



      <210> 1038
      <211> 128
      <212> PRT
      <213> Homo sapiens


      <400> 1038
 Met Tyr Ala Leu Lys Asp Pro Ile Met Gly Gln Gly Ala Arg Ser Gly
   1               5                  10                  15    
 Pro Leu Met Arg Ser Ser Leu Ser Pro Gly Gln Val Asn Thr Leu Ala
              20                  25                  30        
 Gly Ile Gln Lys Thr Ile His Ala Glu His Cys Asn Val Thr Glu Met
          35                  40                  45            
 Ala Ala His Trp Pro Arg Ser Pro Gly Pro Thr Leu Arg Gly His Phe
      50                  55                  60                
 Leu Pro Tyr Gln Gln Gln His Pro Thr Ser Leu Pro Tyr Val Leu Ala
  65                  70                  75                  80
 Phe Pro Gly Ala Pro Asn Pro Gly Leu Ala Asp Arg Arg Ala Leu Pro
                  85                  90                  95    
 Pro Gly Ser Pro Phe Pro Cys Thr Pro Pro Ala Pro Pro Leu Gly Gln
             100                 105                 110        
 Thr Pro Thr Leu Pro His Val Gly Trp Ala Cys Leu Ala Thr Ala Gln
         115                 120                 125            





      <210> 1039
      <211> 441
      <212> PRT
      <213> Homo sapiens


      <400> 1039
 Met Glu Ala Pro Ala Ala Glu Pro Pro Val Arg Gly Cys Gly Pro Gln
   1               5                  10                  15    
 Pro Ala Pro Ala Pro Ala Pro Ala Pro Glu Arg Lys Lys Ser His Arg
              20                  25                  30        
 Ala Pro Ser Pro Ala Arg Pro Lys Asp Val Ala Gly Trp Ser Leu Ala
          35                  40                  45            
 Lys Gly Arg Arg Gly Pro Gly Pro Gly Ser Ala Val Ala Cys Ser Ala
      50                  55                  60                
 Ala Phe Ser Ser Arg Pro Asp Lys Lys Gly Arg Ala Val Ala Pro Gly
  65                  70                  75                  80
 Ala Arg Gly Ala Gly Val Arg Val Ala Gly Val Arg Thr Gly Val Arg
                  85                  90                  95    
 Ala Lys Gly Arg Pro Arg Ser Gly Ala Gly Pro Arg Pro Pro Pro Pro
             100                 105                 110        
 Pro Pro Ser Leu Thr Asp Ser Ser Ser Glu Val Ser Asp Cys Ala Ser
         115                 120                 125            
 Glu Glu Ala Arg Leu Leu Gly Leu Glu Leu Ala Leu Ser Ser Asp Ala
     130                 135                 140                
 Glu Ser Ala Ala Gly Gly Pro Ala Gly Val Arg Thr Gly Gln Pro Ala
 145                 150                 155                 160
 Gln Pro Ala Pro Ser Ala Gln Gln Pro Pro Arg Pro Pro Ala Ser Pro
                 165                 170                 175    
 Asp Glu Pro Ser Val Ala Ala Ser Ser Val Gly Ser Ser Arg Leu Pro
             180                 185                 190        
 Leu Ser Ala Ser Leu Ala Phe Ser Asp Leu Thr Glu Glu Met Leu Asp
         195                 200                 205            
 Cys Gly Pro Ser Gly Leu Val Arg Glu Leu Glu Glu Leu Arg Ser Glu
     210                 215                 220                
 Asn Asp Tyr Leu Lys Asp Glu Ile Glu Glu Leu Arg Ala Glu Met Leu
 225                 230                 235                 240
 Glu Met Arg Asp Val Tyr Met Glu Glu Asp Val Tyr Gln Leu Gln Glu
                 245                 250                 255    
 Leu Arg Gln Gln Leu Asp Gln Ala Ser Lys Thr Cys Arg Ile Leu Gln
             260                 265                 270        
 Tyr Arg Leu Arg Lys Ala Glu Arg Arg Ser Leu Arg Ala Ala Gln Thr
         275                 280                 285            
 Gly Gln Val Asp Gly Glu Leu Ile Arg Gly Leu Glu Gln Asp Val Lys
     290                 295                 300                
 Val Ser Lys Asp Ile Ser Met Arg Leu His Lys Glu Leu Glu Val Val
 305                 310                 315                 320
 Glu Lys Lys Arg Ala Arg Leu Glu Glu Glu Asn Glu Glu Leu Arg Gln
                 325                 330                 335    
 Arg Leu Ile Glu Thr Glu Leu Ala Lys Gln Val Leu Gln Thr Glu Leu
             340                 345                 350        
 Glu Arg Pro Arg Glu Val Arg Thr Ser Cys Ile Gln Gln Gly Gln Pro
         355                 360                 365            
 Arg Ala Gly Gly His Met Gln Ala Pro Pro Ser Gln Cys Leu Cys Glu
     370                 375                 380                
 Pro Pro Leu Val Gly Asn Gly Gln Leu Met Pro Pro Trp Gln Gly Cys
 385                 390                 395                 400
 Leu Phe Ile His Ser Ser Asn Met His Phe Leu Ser Thr Tyr Cys Val
                 405                 410                 415    
 Asn Cys Val Leu Asp Thr Lys Val Thr Met Val Asn Lys Thr His Pro
             420                 425                 430        
 Val Pro Val Leu Arg Glu Leu Thr Gly
         435                 440    



      <210> 1040
      <211> 626
      <212> PRT
      <213> Homo sapiens


      <400> 1040
 Met Tyr Phe Cys Trp Gly Ala Asp Ser Arg Glu Leu Gln Arg Arg Arg
   1               5                  10                  15    
 Thr Ala Gly Ser Pro Gly Ala Glu Leu Leu Gln Ala Ala Ser Gly Glu
              20                  25                  30        
 Arg His Ser Leu Leu Leu Leu Thr Asn His Arg Val Leu Ser Cys Gly
          35                  40                  45            
 Asp Asn Ser Arg Gly Gln Leu Gly Arg Arg Gly Ala Gln Arg Gly Glu
      50                  55                  60                
 Leu Pro Glu Pro Ile Gln Ala Leu Glu Thr Leu Ile Val Asp Leu Val
  65                  70                  75                  80
 Ser Cys Gly Lys Glu His Ser Leu Ala Val Cys His Lys Gly Arg Val
                  85                  90                  95    
 Phe Ala Trp Gly Ala Gly Ser Glu Gly Gln Leu Gly Ile Gly Glu Phe
             100                 105                 110        
 Lys Glu Ile Ser Phe Thr Pro Lys Lys Ile Met Thr Leu Asn Asp Ile
         115                 120                 125            
 Lys Ile Ile Gln Val Ser Cys Gly His Tyr His Ser Leu Ala Leu Ser
     130                 135                 140                
 Lys Asp Ser Gln Val Phe Ser Trp Gly Lys Asn Ser His Gly Gln Leu
 145                 150                 155                 160
 Gly Leu Gly Lys Glu Phe Pro Ser Gln Ala Ser Pro Gln Arg Val Arg
                 165                 170                 175    
 Ser Leu Glu Gly Ile Pro Leu Ala Gln Val Ala Ala Gly Gly Ala His
             180                 185                 190        
 Ser Phe Ala Leu Ser Leu Cys Gly Thr Ser Phe Gly Trp Gly Ser Asn
         195                 200                 205            
 Ser Ala Gly Gln Leu Ala Leu Ser Gly Arg Asn Val Pro Val Gln Ser
     210                 215                 220                
 Asn Lys Pro Leu Ser Val Gly Ala Leu Lys Asn Leu Gly Val Val Tyr
 225                 230                 235                 240
 Ile Ser Cys Gly Asp Ala His Thr Ala Val Leu Thr Gln Asp Gly Lys
                 245                 250                 255    
 Val Phe Thr Phe Gly Asp Asn Arg Ser Gly Gln Leu Gly Tyr Ser Pro
             260                 265                 270        
 Thr Pro Glu Lys Arg Gly Pro Gln Leu Val Glu Arg Ile Asp Gly Leu
         275                 280                 285            
 Val Ser Gln Ile Asp Cys Gly Ser Tyr His Thr Leu Ala Tyr Val His
     290                 295                 300                
 Thr Thr Gly Gln Val Val Ser Phe Gly His Gly Pro Ser Asp Thr Ser
 305                 310                 315                 320
 Lys Pro Thr His Pro Glu Ala Leu Thr Glu Asn Phe Asp Ile Ser Cys
                 325                 330                 335    
 Leu Ile Ser Ala Glu Asp Phe Val Asp Val Gln Val Lys His Ile Phe
             340                 345                 350        
 Ala Gly Thr Tyr Ala Asn Phe Val Thr Thr His Gln Asp Thr Ser Ser
         355                 360                 365            
 Thr Arg Ala Pro Gly Lys Thr Leu Pro Glu Ile Ser Arg Ile Ser Gln
     370                 375                 380                
 Ser Met Ala Glu Lys Trp Ile Ala Val Lys Arg Arg Ser Thr Glu His
 385                 390                 395                 400
 Glu Met Ala Lys Ser Glu Ile Arg Met Ile Phe Ser Ser Pro Ala Cys
                 405                 410                 415    
 Leu Thr Ala Ser Phe Leu Lys Lys Arg Gly Thr Gly Glu Thr Thr Ser
             420                 425                 430        
 Ile Asp Val Asp Leu Glu Met Ala Arg Asp Thr Phe Lys Lys Leu Thr
         435                 440                 445            
 Lys Lys Glu Trp Ile Ser Ser Met Ile Thr Thr Cys Leu Glu Asp Asp
     450                 455                 460                
 Leu Leu Arg Ala Leu Pro Cys His Ser Pro His Gln Glu Ala Leu Ser
 465                 470                 475                 480
 Val Phe Leu Leu Leu Pro Glu Cys Pro Val Met His Asp Ser Lys Asn
                 485                 490                 495    
 Trp Lys Asn Leu Val Val Pro Phe Ala Lys Ala Val Cys Glu Met Ser
             500                 505                 510        
 Lys Gln Ser Leu Gln Val Leu Lys Lys Cys Trp Ala Phe Leu Gln Glu
         515                 520                 525            
 Ser Ser Leu Asn Pro Leu Ile Gln Met Leu Lys Ala Ala Ile Ile Ser
     530                 535                 540                
 Gln Leu Leu His Gln Thr Lys Thr Glu Gln Asp His Cys Asn Val Lys
 545                 550                 555                 560
 Ala Leu Leu Gly Met Met Lys Glu Leu His Lys Val Asn Lys Ala Asn
                 565                 570                 575    
 Cys Arg Leu Pro Glu Asn Thr Phe Asn Ile Asn Glu Leu Ser Asn Leu
             580                 585                 590        
 Leu Asn Phe Tyr Ile Asp Arg Gly Arg Gln Leu Phe Arg Glu Tyr His
         595                 600                 605            
 Leu Ile Pro Ala Glu Thr Pro Gln Pro Val Ile Ser Arg Asp Phe Pro
     610                 615                 620                
 Phe Leu
 625    



      <210> 1041
      <211> 230
      <212> PRT
      <213> Homo sapiens


      <400> 1041
 Met Trp Asp Glu Glu Glu Glu Glu Glu Glu Asp Gln Asp Tyr Tyr Leu
   1               5                  10                  15    
 Gly Gly Leu Arg Pro Asp Leu Arg Ile Asp Val Tyr Arg Glu Glu Glu
              20                  25                  30        
 Ile Leu Glu Ala Tyr Asp Glu Asp Glu Asp Glu Glu Leu Tyr Pro Asp
          35                  40                  45            
 Ile His Pro Pro Pro Ser Leu Pro Leu Pro Gly Gln Phe Thr Cys Pro
      50                  55                  60                
 Gln Cys Arg Lys Ser Phe Thr Arg Arg Ser Phe Arg Pro Asn Leu Gln
  65                  70                  75                  80
 Leu Ala Asn Met Val Gln Ile Ile Arg Gln Met Cys Pro Thr Pro Tyr
                  85                  90                  95    
 Arg Gly Asn Arg Ser Asn Asp Gln Gly Met Cys Phe Lys His Gln Glu
             100                 105                 110        
 Ala Leu Lys Leu Phe Cys Glu Val Asp Lys Glu Ala Ile Cys Val Val
         115                 120                 125            
 Cys Arg Glu Ser Arg Ser His Lys Gln His Ser Val Leu Pro Leu Glu
     130                 135                 140                
 Glu Val Val Gln Glu Tyr Gln Ala Lys Leu Gln Gly His Val Glu Pro
 145                 150                 155                 160
 Leu Arg Lys His Leu Glu Ala Val Gln Lys Met Lys Ala Thr Gly Gly
                 165                 170                 175    
 Glu Ala Ser Asp Arg Thr Glu Glu Pro Asp Glu Val Arg Ala Gly Ser
             180                 185                 190        
 Gly Gly Leu Gly Val Gly Arg Leu Thr Arg Phe Leu Ala Glu Glu Gln
         195                 200                 205            
 Ala Gly Leu Glu Arg Arg Leu Arg Glu Met His Glu Ala Gln Leu Gly
     210                 215                 220                
 Arg Ala Gly Ala Ala Ala
 225                 230



      <210> 1042
      <211> 1124
      <212> PRT
      <213> Homo sapiens


      <400> 1042
 Met Ser Glu Ala Pro Arg Phe Phe Val Gly Pro Glu Asp Thr Glu Ile
   1               5                  10                  15    
 Asn Pro Gly Asn Tyr Arg His Phe Phe His His Ala Asp Glu Asp Asp
              20                  25                  30        
 Glu Glu Glu Asp Asp Ser Pro Pro Glu Arg Gln Ile Val Val Gly Ile
          35                  40                  45            
 Cys Ser Met Ala Lys Lys Ser Lys Ser Lys Pro Met Lys Glu Ile Leu
      50                  55                  60                
 Glu Arg Ile Ser Leu Phe Lys Tyr Ile Thr Val Val Val Phe Glu Glu
  65                  70                  75                  80
 Glu Val Ile Leu Asn Glu Pro Val Glu Asn Trp Pro Leu Cys Asp Cys
                  85                  90                  95    
 Leu Ile Ser Phe His Ser Lys Gly Phe Pro Leu Asp Lys Ala Val Ala
             100                 105                 110        
 Tyr Ala Lys Leu Arg Asn Pro Phe Val Ile Asn Asp Leu Asn Met Gln
         115                 120                 125            
 Tyr Leu Ile Gln Asp Arg Arg Glu Val Tyr Ser Ile Leu Gln Ala Glu
     130                 135                 140                
 Gly Ile Leu Leu Pro Arg Tyr Ala Ile Leu Asn Arg Asp Pro Asn Asn
 145                 150                 155                 160
 Pro Lys Glu Cys Asn Leu Ile Glu Gly Glu Asp His Val Glu Val Asn
                 165                 170                 175    
 Gly Glu Val Phe Gln Lys Pro Phe Val Glu Lys Pro Val Ser Ala Glu
             180                 185                 190        
 Asp His Asn Val Tyr Ile Tyr Tyr Pro Thr Ser Ala Gly Gly Gly Ser
         195                 200                 205            
 Gln Arg Leu Phe Arg Lys Ile Gly Ser Arg Ser Ser Val Tyr Ser Pro
     210                 215                 220                
 Glu Ser Asn Val Arg Lys Thr Gly Ser Tyr Ile Tyr Glu Glu Phe Met
 225                 230                 235                 240
 Pro Thr Asp Gly Thr Asp Val Lys Val Tyr Thr Val Gly Pro Asp Tyr
                 245                 250                 255    
 Ala His Ala Glu Ala Arg Lys Ser Pro Ala Leu Asp Gly Lys Val Glu
             260                 265                 270        
 Arg Asp Ser Glu Gly Lys Glu Val Arg Tyr Pro Val Ile Leu Asn Ala
         275                 280                 285            
 Arg Glu Lys Leu Ile Ala Trp Lys Val Cys Leu Ala Phe Lys Gln Thr
     290                 295                 300                
 Val Cys Gly Phe Asp Leu Leu Arg Ala Asn Gly Gln Ser Tyr Val Cys
 305                 310                 315                 320
 Asp Val Asn Gly Phe Ser Phe Val Lys Asn Ser Met Lys Tyr Tyr Asp
                 325                 330                 335    
 Asp Cys Ala Lys Ile Leu Gly Asn Ile Val Met Arg Glu Leu Ala Pro
             340                 345                 350        
 Gln Phe His Ile Pro Trp Ser Ile Pro Leu Glu Ala Glu Asp Ile Pro
         355                 360                 365            
 Ile Val Pro Thr Thr Ser Gly Thr Met Met Glu Leu Arg Cys Val Ile
     370                 375                 380                
 Ala Val Ile Arg His Gly Asp Arg Thr Pro Lys Lys Lys Met Lys Met
 385                 390                 395                 400
 Glu Val Arg His Gln Lys Phe Phe Asp Leu Phe Glu Lys Cys Asp Gly
                 405                 410                 415    
 Tyr Lys Ser Gly Lys Leu Lys Leu Lys Lys Pro Lys Gln Leu Gln Glu
             420                 425                 430        
 Val Leu Asp Ile Ala Arg Gln Leu Leu Met Glu Leu Gly Gln Asn Asn
         435                 440                 445            
 Asp Ser Glu Ile Glu Glu Asn Lys Pro Lys Leu Glu Gln Leu Lys Thr
     450                 455                 460                
 Val Leu Glu Met Tyr Gly His Phe Ser Gly Ile Asn Arg Lys Val Gln
 465                 470                 475                 480
 Leu Thr Tyr Leu Pro His Gly Cys Pro Lys Thr Ser Ser Glu Glu Glu
                 485                 490                 495    
 Asp Ser Arg Arg Glu Glu Pro Ser Leu Leu Leu Val Leu Lys Trp Gly
             500                 505                 510        
 Gly Glu Leu Thr Pro Ala Gly Arg Val Gln Ala Glu Glu Leu Gly Arg
         515                 520                 525            
 Ala Phe Arg Cys Met Tyr Pro Gly Gly Gln Gly Asp Tyr Ala Gly Phe
     530                 535                 540                
 Pro Gly Cys Gly Leu Leu Arg Leu His Ser Thr Tyr Arg His Asp Leu
 545                 550                 555                 560
 Lys Ile Tyr Ala Ser Asp Glu Gly Arg Val Gln Met Thr Ala Ala Ala
                 565                 570                 575    
 Phe Ala Lys Gly Leu Leu Ala Leu Glu Gly Glu Leu Thr Pro Ile Leu
             580                 585                 590        
 Val Gln Met Val Lys Ser Ala Asn Met Asn Gly Leu Leu Asp Ser Asp
         595                 600                 605            
 Ser Asp Ser Leu Ser Ser Cys Gln Gln Arg Val Lys Ala Arg Leu His
     610                 615                 620                
 Glu Ile Leu Gln Lys Asp Arg Asp Phe Thr Ala Glu Asp Tyr Glu Lys
 625                 630                 635                 640
 Leu Thr Pro Ser Gly Ser Ile Ser Leu Ile Lys Ser Met His Leu Ile
                 645                 650                 655    
 Lys Asn Pro Val Lys Thr Cys Asp Lys Val Tyr Ser Leu Ile Gln Ser
             660                 665                 670        
 Leu Thr Ser Gln Ile Arg His Arg Met Glu Asp Pro Lys Ser Ser Asp
         675                 680                 685            
 Ile Gln Leu Tyr His Ser Glu Thr Leu Glu Leu Met Leu Arg Arg Trp
     690                 695                 700                
 Ser Lys Leu Glu Lys Asp Phe Lys Thr Lys Asn Gly Arg Tyr Asp Ile
 705                 710                 715                 720
 Ser Lys Ile Pro Asp Ile Tyr Asp Cys Ile Lys Tyr Asp Val Gln His
                 725                 730                 735    
 Asn Gly Ser Leu Lys Leu Glu Asn Thr Met Glu Leu Tyr Arg Leu Ser
             740                 745                 750        
 Lys Ala Leu Ala Asp Ile Val Ile Pro Gln Glu Tyr Gly Ile Thr Lys
         755                 760                 765            
 Ala Glu Lys Leu Glu Ile Ala Lys Gly Tyr Cys Thr Pro Leu Val Arg
     770                 775                 780                
 Lys Ile Arg Ser Asp Leu Gln Arg Thr Gln Asp Asp Asp Thr Val Asn
 785                 790                 795                 800
 Lys Leu His Pro Val Tyr Ser Arg Gly Val Leu Ser Pro Glu Arg His
                 805                 810                 815    
 Val Arg Thr Arg Leu Tyr Phe Thr Ser Glu Ser His Val His Ser Leu
             820                 825                 830        
 Leu Ser Ile Leu Arg Tyr Gly Ala Leu Cys Asn Glu Ser Lys Asp Glu
         835                 840                 845            
 Gln Trp Lys Arg Ala Met Asp Tyr Leu Asn Val Val Asn Glu Leu Asn
     850                 855                 860                
 Tyr Met Thr Gln Ile Val Ile Met Leu Tyr Glu Asp Pro Asn Lys Asp
 865                 870                 875                 880
 Leu Ser Ser Glu Glu Arg Phe His Val Glu Leu His Phe Ser Pro Gly
                 885                 890                 895    
 Ala Lys Gly Cys Glu Glu Asp Lys Asn Leu Pro Ser Gly Tyr Gly Tyr
             900                 905                 910        
 Arg Pro Ala Ser Arg Glu Asn Glu Gly Arg Arg Pro Phe Lys Ile Asp
         915                 920                 925            
 Asn Asp Asp Glu Pro His Thr Ser Lys Arg Asp Glu Val Asp Arg Ala
     930                 935                 940                
 Val Ile Leu Phe Lys Pro Met Val Ser Glu Pro Ile His Ile His Arg
 945                 950                 955                 960
 Lys Ser Pro Leu Pro Arg Ser Arg Lys Thr Ala Thr Asn Asp Val Val
                 965                 970                 975    
 Ser Glu Asn Ala Asn Tyr Leu Arg Thr Pro Arg Thr Leu Val Glu Gln
             980                 985                 990        
 Lys Gln Asn Pro Thr Val Gly Phe Glu Leu Tyr Ser Met Val Pro Ser
         995                1000                1005            
 Ile Cys Pro Leu Glu Thr Leu His Asn Ala Leu Ser Leu Lys Gln Val
    1010                1015                1020                
 Asp Glu Phe Leu Ala Ser Ile Ala Ser Pro Ser Ser Asp Val Pro Arg
1025                1030                1035                1040
 Lys Thr Ala Glu Ile Ser Ser Thr Ala Leu Arg Ser Ser Pro Ile Met
                1045                1050                1055    
 Arg Lys Lys Val Ser Leu Asn Thr Tyr Thr Pro Ala Lys Ile Leu Pro
            1060                1065                1070        
 Thr Pro Pro Ala Thr Leu Lys Ser Thr Lys Ala Ser Ser Lys Pro Ala
        1075                1080                1085            
 Thr Ser Gly Pro Ser Ser Ala Val Val Pro Asn Thr Ser Ser Arg Lys
    1090                1095                1100                
 Lys Asn Ile Thr Ser Lys Thr Glu Thr His Glu His Lys Lys Asn Thr
1105                1110                1115                1120
 Gly Lys Lys Lys
                



      <210> 1043
      <211> 579
      <212> PRT
      <213> Homo sapiens


      <400> 1043
 Met Glu Ile Ala Ser Phe Val Gly Pro Asn Val Asn Thr Val Gly Asn
   1               5                  10                  15    
 Leu Arg Pro Ala Gln Ser Ala Ala Gly Asp Gly Asp Glu Val Gln Ser
              20                  25                  30        
 Val His Ser Gln Arg Gln Asp Cys Gln Ala Thr Gly Ser Leu Ser Asn
          35                  40                  45            
 Gly Glu Asn Asn Glu Lys Asn Ala Phe Thr Thr Tyr Gln Gln Glu Thr
      50                  55                  60                
 Lys Asn Thr Thr Thr Pro Gln Ser Val Tyr Phe Leu Gly Val Asn Lys
  65                  70                  75                  80
 Met Ser Ser Gln His Arg Glu Gly Ser Arg Gly Thr Ser Pro Pro Leu
                  85                  90                  95    
 Pro Val Leu Ala Cys Phe Glu Leu Ala Val Ala Arg Val Gly Pro Arg
             100                 105                 110        
 Thr Pro Glu Val Val Arg Arg Ser Leu Ala Ala Glu Gly Ala Gly Ser
         115                 120                 125            
 Arg Gly Leu Asp Cys Phe Arg Leu Ala Arg Arg Ser Lys Met Ala Asp
     130                 135                 140                
 Ile Ser Leu Asp Glu Leu Ile Arg Lys Arg Gly Ala Ala Ala Lys Gly
 145                 150                 155                 160
 Arg Leu Asn Ala Arg Pro Gly Val Gly Gly Val Arg Ser Arg Val Gly
                 165                 170                 175    
 Ile Gln Gln Gly Leu Leu Ser Gln Ser Thr Arg Thr Ala Thr Phe Gln
             180                 185                 190        
 Gln Arg Phe Asp Ala Arg Gln Lys Ile Gly Leu Ser Asp Ala Arg Leu
         195                 200                 205            
 Lys Leu Gly Val Lys Asp Ala Arg Glu Lys Leu Leu Gln Lys Asp Ala
     210                 215                 220                
 Arg Phe Arg Ile Lys Gly Lys Val Gln Asp Ala Arg Glu Met Leu Asn
 225                 230                 235                 240
 Ser Arg Lys Gln Gln Thr Thr Val Pro Gln Lys Pro Arg Gln Val Ala
                 245                 250                 255    
 Asp Ala Arg Glu Lys Ile Ser Leu Lys Arg Ser Ser Pro Ala Ala Phe
             260                 265                 270        
 Ile Asn Pro Pro Ile Gly Thr Val Thr Pro Ala Leu Lys Leu Thr Lys
         275                 280                 285            
 Thr Ile Gln Arg Met His Val Asp Pro Val Gly Trp Ile Leu Thr Thr
     290                 295                 300                
 Glu Cys Phe Gln Val Pro Gln Gln Lys Ala Met Ala Pro Leu His Pro
 305                 310                 315                 320
 His Pro Ala Gly Met Arg Ile Asn Val Val Asn Asn His Gln Ala Lys
                 325                 330                 335    
 Gln Asn Leu Tyr Asp Leu Asp Glu Asp Asp Asp Gly Ile Ala Ser Val
             340                 345                 350        
 Pro Thr Lys Gln Met Lys Phe Ala Ala Ser Gly Gly Phe Leu His His
         355                 360                 365            
 Met Ala Gly Leu Ser Ser Ser Lys Leu Ser Met Ser Lys Ala Leu Pro
     370                 375                 380                
 Leu Thr Lys Val Val Gln Asn Asp Ala Tyr Thr Ala Pro Ala Leu Pro
 385                 390                 395                 400
 Ser Ser Ile Arg Thr Lys Ala Leu Thr Asn Met Ser Arg Thr Leu Val
                 405                 410                 415    
 Asn Lys Glu Glu Pro Pro Lys Glu Leu Pro Ala Ala Glu Pro Val Leu
             420                 425                 430        
 Ser Pro Leu Glu Gly Thr Lys Met Thr Val Asn Asn Leu His Pro Arg
         435                 440                 445            
 Val Thr Glu Glu Asp Ile Val Glu Leu Phe Cys Val Cys Gly Ala Leu
     450                 455                 460                
 Lys Arg Ala Arg Leu Val His Pro Gly Val Ala Glu Val Val Phe Val
 465                 470                 475                 480
 Lys Lys Asp Asp Ala Ile Thr Ala Tyr Lys Lys Tyr Asn Asn Arg Cys
                 485                 490                 495    
 Leu Asp Gly Gln Pro Met Lys Cys Asn Leu His Met Asn Gly Asn Val
             500                 505                 510        
 Ile Thr Ser Asp Gln Pro Ile Leu Leu Arg Leu Ser Asp Ser Pro Ser
         515                 520                 525            
 Met Lys Lys Glu Ser Glu Leu Pro Arg Arg Val Asn Ser Ala Ser Ser
     530                 535                 540                
 Ser Asn Pro Pro Ala Glu Val Asp Pro Asp Thr Ile Leu Lys Ala Leu
 545                 550                 555                 560
 Phe Lys Ser Ser Gly Ala Ser Val Thr Thr Gln Pro Thr Glu Phe Lys
                 565                 570                 575    
 Ile Lys Leu
            



      <210> 1044
      <211> 78
      <212> PRT
      <213> Homo sapiens


      <400> 1044
 Met Gly Thr Trp Gln Leu Lys Thr Asp Gly Ser Arg Thr Lys Glu Thr
   1               5                  10                  15    
 Phe Ala Leu Glu Ala Gln Pro Asn Ser Pro Gly His Arg His Arg Trp
              20                  25                  30        
 His Leu Glu His Gly Leu Pro Gln Ser Gly Gly Arg Ala Cys Val Val
          35                  40                  45            
 Gln Arg Ala Gln Pro Gly Thr Lys Lys Glu Met Arg Pro Leu Ser Ser
      50                  55                  60                
 Met Ser Pro Cys Pro Asp Thr Tyr Leu Gly Arg Asn Phe Phe
  65                  70                  75            



      <210> 1045
      <211> 1412
      <212> PRT
      <213> Homo sapiens


      <400> 1045
 Met Lys Gln Ala Lys Glu Glu Ala Gly Gly Asp Glu Ser Arg Glu Glu
   1               5                  10                  15    
 Ala Gly Cys Tyr Gly Thr Trp Cys Gly Val Arg Glu Arg Asn Leu Lys
              20                  25                  30        
 Gln Lys Asp Ala Ser His Val Leu Thr Met Ser Ala Pro Asp Glu Gly
          35                  40                  45            
 Arg Arg Asp Pro Pro Lys Pro Lys Gly Lys Thr Leu Gly Ser Phe Phe
      50                  55                  60                
 Gly Ser Leu Pro Gly Phe Ser Ser Ala Arg Asn Leu Val Ala Asn Ala
  65                  70                  75                  80
 His Ser Ser Ala Arg Ala Arg Pro Ala Ala Asp Pro Thr Gly Ala Pro
                  85                  90                  95    
 Ala Ala Glu Ala Ala Gln Pro Gln Ala Gln Val Ala Ala His Pro Glu
             100                 105                 110        
 Gln Thr Ala Pro Trp Thr Glu Lys Glu Leu Gln Pro Ser Glu Lys Met
         115                 120                 125            
 Val Ser Gly Ala Lys Asp Leu Val Cys Ser Lys Met Ser Arg Ala Lys
     130                 135                 140                
 Asp Ala Val Ser Ser Gly Val Ala Ser Val Val Asp Val Ala Lys Gly
 145                 150                 155                 160
 Val Val Gln Gly Gly Leu Asp Thr Thr Arg Ser Ala Leu Thr Gly Thr
                 165                 170                 175    
 Lys Glu Val Val Ser Ser Gly Val Thr Gly Ala Met Asp Met Ala Lys
             180                 185                 190        
 Gly Ala Val Gln Gly Gly Leu Asp Thr Ser Lys Ala Val Leu Thr Gly
         195                 200                 205            
 Thr Lys Asp Thr Val Ser Thr Gly Leu Thr Gly Ala Val Asn Val Ala
     210                 215                 220                
 Lys Gly Thr Val Gln Ala Gly Val Asp Thr Thr Lys Thr Val Leu Thr
 225                 230                 235                 240
 Gly Thr Lys Asp Thr Val Thr Thr Gly Val Met Gly Ala Val Asn Leu
                 245                 250                 255    
 Ala Lys Gly Thr Val Gln Thr Gly Val Glu Thr Ser Lys Ala Val Leu
             260                 265                 270        
 Thr Gly Thr Lys Asp Ala Val Ser Thr Gly Leu Thr Gly Ala Val Asn
         275                 280                 285            
 Val Ala Arg Gly Ser Ile Gln Thr Gly Val Asp Thr Ser Lys Thr Val
     290                 295                 300                
 Leu Thr Gly Thr Lys Asp Thr Val Cys Ser Gly Val Thr Gly Ala Met
 305                 310                 315                 320
 Asn Val Ala Lys Gly Thr Ile Gln Thr Gly Val Asp Thr Ser Lys Thr
                 325                 330                 335    
 Val Leu Thr Gly Thr Lys Asp Thr Val Cys Ser Gly Val Thr Gly Ala
             340                 345                 350        
 Met Asn Val Ala Lys Gly Thr Ile Gln Thr Gly Val Asp Thr Ser Lys
         355                 360                 365            
 Thr Val Leu Thr Gly Thr Lys Asp Thr Val Cys Ser Gly Val Thr Gly
     370                 375                 380                
 Ala Met Asn Val Ala Lys Gly Thr Ile Gln Thr Gly Val Asp Thr Thr
 385                 390                 395                 400
 Lys Thr Val Leu Thr Gly Thr Lys Asn Thr Val Cys Ser Gly Val Thr
                 405                 410                 415    
 Gly Ala Val Asn Leu Ala Lys Glu Ala Ile Gln Gly Gly Leu Asp Thr
             420                 425                 430        
 Thr Lys Ser Met Val Met Gly Thr Lys Asp Thr Met Ser Thr Gly Leu
         435                 440                 445            
 Thr Gly Ala Ala Asn Val Ala Lys Gly Ala Met Gln Thr Gly Leu Asn
     450                 455                 460                
 Thr Thr Gln Asn Ile Ala Thr Gly Thr Lys Asp Thr Val Cys Ser Gly
 465                 470                 475                 480
 Val Thr Gly Ala Met Asn Leu Ala Arg Gly Thr Ile Gln Thr Gly Val
                 485                 490                 495    
 Asp Thr Thr Lys Ile Val Leu Thr Gly Thr Lys Asp Thr Val Cys Ser
             500                 505                 510        
 Gly Val Thr Gly Ala Ala Asn Val Ala Lys Gly Ala Val Gln Gly Gly
         515                 520                 525            
 Leu Asp Thr Thr Lys Ser Val Leu Thr Gly Thr Lys Asp Ala Val Ser
     530                 535                 540                
 Thr Gly Leu Thr Gly Ala Val Asn Val Ala Lys Gly Thr Val Gln Thr
 545                 550                 555                 560
 Gly Val Asp Thr Thr Lys Thr Val Leu Thr Gly Thr Lys Asp Thr Val
                 565                 570                 575    
 Cys Ser Gly Val Thr Ser Ala Val Asn Val Ala Lys Gly Ala Val Gln
             580                 585                 590        
 Gly Gly Leu Asp Thr Thr Lys Ser Val Val Ile Gly Thr Lys Asp Thr
         595                 600                 605            
 Met Ser Thr Gly Leu Thr Gly Ala Ala Asn Val Ala Lys Gly Ala Val
     610                 615                 620                
 Gln Thr Gly Val Asp Thr Ala Lys Thr Val Leu Thr Gly Thr Lys Asp
 625                 630                 635                 640
 Thr Val Thr Thr Gly Leu Val Gly Ala Val Asn Val Ala Lys Gly Thr
                 645                 650                 655    
 Val Gln Thr Gly Met Asp Thr Thr Lys Thr Val Leu Thr Gly Thr Lys
             660                 665                 670        
 Asp Thr Ile Tyr Ser Gly Val Thr Ser Ala Val Asn Val Ala Lys Gly
         675                 680                 685            
 Ala Val Gln Thr Gly Leu Lys Thr Thr Gln Asn Ile Ala Thr Gly Thr
     690                 695                 700                
 Lys Asn Thr Phe Gly Ser Gly Val Thr Ser Ala Val Asn Val Ala Lys
 705                 710                 715                 720
 Gly Ala Ala Gln Thr Gly Val Asp Thr Ala Lys Thr Val Leu Thr Gly
                 725                 730                 735    
 Thr Lys Asp Thr Val Thr Thr Gly Leu Met Gly Ala Val Asn Val Ala
             740                 745                 750        
 Lys Gly Thr Val Gln Thr Ser Val Asp Thr Thr Lys Thr Val Leu Thr
         755                 760                 765            
 Gly Thr Lys Asp Thr Val Cys Ser Gly Val Thr Gly Ala Ala Asn Val
     770                 775                 780                
 Ala Lys Gly Ala Ile Gln Gly Gly Leu Asp Thr Thr Lys Ser Val Leu
 785                 790                 795                 800
 Thr Gly Thr Lys Asp Ala Val Ser Thr Gly Leu Thr Gly Ala Val Lys
                 805                 810                 815    
 Leu Ala Lys Gly Thr Val Gln Thr Gly Met Asp Thr Thr Lys Thr Val
             820                 825                 830        
 Leu Thr Gly Thr Lys Asp Ala Val Cys Ser Gly Val Thr Gly Ala Ala
         835                 840                 845            
 Asn Val Ala Lys Gly Ala Val Gln Met Gly Val Asp Thr Ala Lys Thr
     850                 855                 860                
 Val Leu Thr Gly Thr Lys Asp Thr Val Cys Ser Gly Val Thr Gly Ala
 865                 870                 875                 880
 Ala Asn Val Ala Lys Gly Ala Val Gln Thr Gly Leu Lys Thr Thr Gln
                 885                 890                 895    
 Asn Ile Ala Thr Gly Thr Lys Asn Thr Leu Gly Ser Gly Val Thr Gly
             900                 905                 910        
 Ala Ala Lys Val Ala Lys Gly Ala Val Gln Gly Gly Leu Asp Thr Thr
         915                 920                 925            
 Lys Ser Val Leu Thr Gly Thr Lys Asp Ala Val Ser Thr Gly Leu Thr
     930                 935                 940                
 Gly Ala Val Asn Leu Ala Lys Gly Thr Val Gln Thr Gly Val Asp Thr
 945                 950                 955                 960
 Ser Lys Thr Val Leu Thr Gly Thr Lys Asp Thr Val Cys Ser Gly Val
                 965                 970                 975    
 Thr Gly Ala Val Asn Val Ala Lys Gly Thr Val Gln Thr Gly Val Asp
             980                 985                 990        
 Thr Ala Lys Thr Val Leu Ser Gly Ala Lys Asp Ala Val Thr Thr Gly
         995                1000                1005            
 Val Thr Gly Ala Val Asn Val Ala Lys Gly Thr Val Gln Thr Gly Val
    1010                1015                1020                
 Asp Ala Ser Lys Ala Val Leu Met Gly Thr Lys Asp Thr Val Phe Ser
1025                1030                1035                1040
 Gly Val Thr Gly Ala Met Ser Met Ala Lys Gly Ala Val Gln Gly Gly
                1045                1050                1055    
 Leu Asp Thr Thr Lys Thr Val Leu Thr Gly Thr Lys Asp Ala Val Ser
            1060                1065                1070        
 Ala Gly Leu Met Gly Ser Gly Asn Val Ala Thr Gly Ala Thr His Thr
        1075                1080                1085            
 Gly Leu Ser Thr Phe Gln Asn Trp Leu Pro Ser Thr Pro Ala Thr Ser
    1090                1095                1100                
 Trp Gly Gly Leu Thr Ser Ser Arg Thr Thr Asp Asn Gly Gly Glu Gln
1105                1110                1115                1120
 Thr Ala Leu Ser Pro Gln Glu Ala Pro Phe Ser Gly Ile Ser Thr Pro
                1125                1130                1135    
 Pro Asp Val Leu Ser Val Gly Pro Glu Pro Ala Trp Glu Ala Ala Ala
            1140                1145                1150        
 Thr Thr Lys Gly Leu Ala Thr Asp Val Ala Thr Phe Thr Gln Gly Ala
        1155                1160                1165            
 Ala Pro Gly Arg Glu Asp Thr Gly Leu Leu Ala Thr Thr His Gly Pro
    1170                1175                1180                
 Glu Glu Ala Pro Arg Leu Ala Met Leu Gln Asn Glu Leu Glu Gly Leu
1185                1190                1195                1200
 Gly Asp Ile Phe His Pro Met Asn Ala Glu Glu Gln Ala Gln Leu Ala
                1205                1210                1215    
 Ala Ser Gln Pro Gly Pro Lys Val Leu Ser Ala Glu Gln Gly Ser Tyr
            1220                1225                1230        
 Phe Val Arg Leu Gly Asp Leu Gly Pro Ser Phe Arg Gln Arg Ala Phe
        1235                1240                1245            
 Glu His Ala Val Ser His Leu Gln His Gly Gln Phe Gln Ala Arg Asp
    1250                1255                1260                
 Thr Leu Ala Gln Leu Gln Asp Cys Phe Arg Leu Ile Glu Lys Ala Gln
1265                1270                1275                1280
 Gln Ala Pro Glu Gly Gln Pro Arg Leu Asp Gln Gly Ser Gly Ala Ser
                1285                1290                1295    
 Ala Glu Asp Ala Ala Val Gln Glu Glu Arg Asp Ala Gly Val Leu Ser
            1300                1305                1310        
 Arg Val Cys Gly Leu Leu Arg Gln Leu His Thr Ala Tyr Ser Gly Leu
        1315                1320                1325            
 Val Ser Ser Leu Gln Gly Leu Pro Ala Glu Leu Gln Gln Pro Val Gly
    1330                1335                1340                
 Arg Ala Arg His Ser Leu Cys Glu Leu Tyr Gly Ile Val Ala Ser Ala
1345                1350                1355                1360
 Gly Ser Val Glu Glu Leu Pro Ala Glu Arg Leu Val Gln Ser Arg Glu
                1365                1370                1375    
 Gly Val His Gln Ala Trp Gln Gly Leu Glu Gln Leu Leu Glu Gly Leu
            1380                1385                1390        
 Gln His Asn Pro Pro Leu Ser Trp Leu Val Gly Pro Phe Ala Leu Pro
        1395                1400                1405            
 Ala Gly Gly Gln
    1410        



      <210> 1046
      <211> 264
      <212> PRT
      <213> Homo sapiens


      <400> 1046
 Met Asp Glu Thr Val Ala Glu Phe Ile Lys Arg Thr Ile Leu Lys Ile
   1               5                  10                  15    
 Pro Met Asn Glu Leu Thr Thr Ile Leu Lys Ala Trp Asp Phe Leu Ser
              20                  25                  30        
 Glu Asn Gln Leu Gln Thr Val Asn Phe Arg Gln Arg Lys Glu Ser Val
          35                  40                  45            
 Val Gln His Leu Ile His Leu Cys Glu Glu Lys Arg Ala Ser Ile Ser
      50                  55                  60                
 Asp Ala Ala Leu Leu Asp Ile Ile Tyr Met Gln Phe His Gln His Gln
  65                  70                  75                  80
 Lys Val Trp Asp Val Phe Gln Met Ser Lys Gly Pro Gly Glu Asp Val
                  85                  90                  95    
 Asp Leu Phe Asp Met Lys Gln Phe Lys Asn Ser Phe Lys Lys Ile Leu
             100                 105                 110        
 Gln Arg Ala Leu Lys Asn Val Thr Val Ser Phe Arg Glu Thr Glu Glu
         115                 120                 125            
 Asn Ala Val Trp Ile Arg Ile Ala Trp Gly Thr Gln Tyr Thr Lys Pro
     130                 135                 140                
 Asn Gln Tyr Lys Pro Thr Tyr Val Val Tyr Tyr Ser Gln Thr Pro Tyr
 145                 150                 155                 160
 Ala Phe Thr Ser Ser Ser Met Leu Arg Arg Asn Thr Pro Leu Leu Gly
                 165                 170                 175    
 Gln Ala Leu Thr Ile Ala Ser Lys His His Gln Ile Val Lys Met Asp
             180                 185                 190        
 Leu Arg Ser Arg Tyr Leu Asp Ser Leu Lys Ala Ile Val Phe Lys Gln
         195                 200                 205            
 Tyr Asn Gln Thr Phe Glu Thr His Asn Ser Thr Thr Pro Leu Gln Glu
     210                 215                 220                
 Arg Ser Leu Gly Leu Asp Ile Asn Met Asp Ser Arg Ile Ile His Glu
 225                 230                 235                 240
 Asn Ile Val Glu Lys Glu Arg Val Gln Thr Asn Asn Ser Arg Thr His
                 245                 250                 255    
 Leu Glu Ile Ile Leu Asn His Asn
             260                



      <210> 1047
      <211> 148
      <212> PRT
      <213> Homo sapiens


      <400> 1047
 Met His Arg Gly Gly Gln Pro Leu Lys Lys Arg Arg Gly Ser Phe Lys
   1               5                  10                  15    
 Met Ala Glu Leu Asp Gln Leu Pro Asp Glu Ser Ser Ser Ala Lys Ala
              20                  25                  30        
 Leu Val Ser Leu Lys Glu Gly Ser Leu Ser Asn Thr Trp Asn Glu Lys
          35                  40                  45            
 Tyr Ser Ser Leu Gln Lys Thr Pro Val Trp Lys Gly Arg Asn Thr Ser
      50                  55                  60                
 Ser Ala Val Glu Met Pro Phe Arg Asn Ser Lys Arg Ser Arg Leu Phe
  65                  70                  75                  80
 Ser Asp Glu Asp Asp Arg Gln Ile Asn Thr Arg Ser Pro Lys Arg Asn
                  85                  90                  95    
 Gln Arg Val Ala Met Val Pro Gln Lys Phe Thr Ala Thr Met Ser Thr
             100                 105                 110        
 Pro Asp Lys Lys Ala Ser Gln Lys Ile Gly Phe Arg Leu Arg Asn Leu
         115                 120                 125            
 Leu Lys Leu Pro Lys Ala His Lys Trp Cys Ile Tyr Glu Trp Phe Tyr
     130                 135                 140                
 Ser Lys Asn Lys
 145            



      <210> 1048
      <211> 328
      <212> PRT
      <213> Homo sapiens


      <400> 1048
 Met Val Phe Gln Phe Pro Ser Thr Glu Gln Arg Ala Val Arg Glu Lys
   1               5                  10                  15    
 Lys Ile Gln Ser Ile Leu Asn Gln Lys Ile Arg Asn Leu Arg Ala Leu
              20                  25                  30        
 Pro Ile Asn Ala Ser Ser Val Gln Val Asn Val Ala Met Val Lys Asn
          35                  40                  45            
 Gly Asn Val Gly Pro Gly Ser Gly Ala Gly Glu Ala Pro Gly Leu Gly
      50                  55                  60                
 Ala Gly Pro Ala Trp Ser Pro Met Ser Ser Ser Thr Gly Glu Leu Thr
  65                  70                  75                  80
 Val Gln Ala Ser Cys Gly Lys Arg Val Val Pro Leu Asn Val Asn Arg
                  85                  90                  95    
 Ile Ala Ser Gly Val Ile Ala Pro Lys Ala Ala Trp Pro Trp Gln Ala
             100                 105                 110        
 Ser Leu Gln Tyr Asp Asn Ile His Gln Cys Gly Ala Thr Leu Ile Ser
         115                 120                 125            
 Asn Thr Trp Leu Val Thr Ala Ala His Cys Phe Gln Lys Tyr Lys Asn
     130                 135                 140                
 Pro His Gln Trp Thr Val Ser Phe Gly Thr Lys Ile Asn Pro Pro Leu
 145                 150                 155                 160
 Met Lys Arg Asn Val Arg Arg Phe Ile Ile His Glu Lys Tyr Arg Ser
                 165                 170                 175    
 Ala Ala Arg Glu Tyr Asp Ile Ala Val Val Gln Val Ser Ser Arg Val
             180                 185                 190        
 Thr Phe Ser Asp Asp Ile Arg Gln Ile Cys Leu Pro Glu Ala Ser Ala
         195                 200                 205            
 Ser Phe Gln Pro Asn Leu Thr Val His Ile Thr Gly Phe Gly Ala Leu
     210                 215                 220                
 Tyr Tyr Gly Gly Glu Ser Gln Asn Asp Leu Arg Glu Ala Arg Val Lys
 225                 230                 235                 240
 Ile Ile Ser Asp Asp Val Cys Lys Gln Pro Gln Val Tyr Gly Asn Asp
                 245                 250                 255    
 Ile Lys Pro Gly Met Phe Cys Ala Gly Tyr Met Glu Gly Ile Tyr Asp
             260                 265                 270        
 Ala Cys Arg Gly Asp Ser Gly Gly Pro Leu Val Thr Arg Asp Leu Lys
         275                 280                 285            
 Asp Thr Trp Tyr Leu Ile Gly Ile Val Ser Trp Gly Asp Asn Cys Gly
     290                 295                 300                
 Gln Lys Asp Lys Pro Gly Val Tyr Thr Gln Val Thr Tyr Tyr Arg Asn
 305                 310                 315                 320
 Trp Ile Ala Ser Lys Thr Gly Ile
                 325            



      <210> 1049
      <211> 300
      <212> PRT
      <213> Homo sapiens


      <400> 1049
 Met Val Phe Gln Phe Pro Ser Thr Glu Gln Arg Ala Val Arg Glu Lys
   1               5                  10                  15    
 Lys Ile Gln Ser Ile Leu Asn Gln Lys Ile Arg Asn Leu Arg Ala Leu
              20                  25                  30        
 Pro Ile Asn Ala Ser Ser Val Gln Val Asn Ala Met Ser Ser Ser Thr
          35                  40                  45            
 Gly Glu Leu Thr Val Gln Ala Ser Cys Gly Lys Arg Val Val Pro Leu
      50                  55                  60                
 Asn Val Asn Arg Ile Ala Ser Gly Val Ile Ala Pro Lys Ala Ala Trp
  65                  70                  75                  80
 Pro Trp Gln Ala Ser Leu Gln Tyr Asp Asn Ile His Gln Cys Gly Ala
                  85                  90                  95    
 Thr Leu Ile Ser Asn Thr Trp Leu Val Thr Ala Ala His Cys Phe Gln
             100                 105                 110        
 Lys Tyr Lys Asn Pro His Gln Trp Thr Val Ser Phe Gly Thr Lys Ile
         115                 120                 125            
 Asn Pro Pro Leu Met Lys Arg Asn Val Arg Arg Phe Ile Ile His Glu
     130                 135                 140                
 Lys Tyr Arg Ser Ala Ala Arg Glu Tyr Asp Ile Ala Val Val Gln Val
 145                 150                 155                 160
 Ser Ser Arg Val Thr Phe Ser Asp Asp Ile Arg Arg Ile Cys Leu Pro
                 165                 170                 175    
 Glu Ala Ser Ala Ser Phe Gln Pro Asn Leu Thr Val His Ile Thr Gly
             180                 185                 190        
 Phe Gly Ala Leu Tyr Tyr Gly Gly Glu Ser Gln Asn Asp Leu Arg Glu
         195                 200                 205            
 Ala Arg Val Lys Ile Ile Ser Asp Asp Val Cys Lys Gln Pro Gln Val
     210                 215                 220                
 Tyr Gly Asn Asp Ile Lys Pro Gly Met Phe Cys Ala Gly Tyr Met Glu
 225                 230                 235                 240
 Gly Ile Tyr Asp Ala Cys Arg Gly Asp Ser Gly Gly Pro Leu Val Thr
                 245                 250                 255    
 Arg Asp Leu Lys Asp Thr Trp Tyr Leu Ile Gly Ile Val Ser Trp Gly
             260                 265                 270        
 Asp Asn Cys Gly Gln Lys Asp Lys Pro Gly Val Tyr Thr Gln Val Thr
         275                 280                 285            
 Tyr Tyr Arg Asn Trp Ile Ala Ser Lys Thr Gly Ile
     290                 295                 300



      <210> 1050
      <211> 416
      <212> PRT
      <213> Homo sapiens


      <400> 1050
 Met Phe Ala Leu Phe Lys Lys Lys Lys Gln Asp Ala Gly Leu Asn Gly
   1               5                  10                  15    
 Ile Thr Glu Arg Tyr Val Val Asp Phe Gln Cys Asn Phe Pro Ala Ile
              20                  25                  30        
 Arg Ala Pro Arg Met Arg Arg Arg Leu Ala Val Gly Arg Arg Cys Glu
          35                  40                  45            
 Glu Ala Leu Ser Thr Gly Glu Thr Leu Asn Cys Glu Glu Val Leu Cys
      50                  55                  60                
 Cys Glu Glu Met Leu Asn Cys Glu Glu Ala Leu Ser Cys Glu Glu Ala
  65                  70                  75                  80
 Leu Ser Cys Glu Glu Ala Leu Ser Cys Glu Glu Ala Leu Ser Cys Glu
                  85                  90                  95    
 Val Leu Ser Cys Glu Glu Met Leu Asn Cys Glu Glu Ala Leu Cys Cys
             100                 105                 110        
 Gly Glu Ala Leu Ser Cys Glu Glu Ala Leu Cys Met Arg Glu Ala Leu
         115                 120                 125            
 Gly Arg Gly Glu Ala Leu Gly Ser Gly Glu Ala Leu Gly Ser Gly Glu
     130                 135                 140                
 Ala Leu Cys Ser Gly Glu Ala Leu Cys Arg Gly Glu Ala Leu Gly Ser
 145                 150                 155                 160
 Glu Glu Ala Leu Cys Ser Glu Glu Ala Leu Cys Ser Glu Glu Val Leu
                 165                 170                 175    
 Cys Arg Gly Glu Ala Leu Gly Ser Glu Glu Ala Leu Cys Ser Glu Glu
             180                 185                 190        
 Ala Leu Gly Ser Glu Glu Val Leu Cys Arg Gly Glu Ala Leu Asn Cys
         195                 200                 205            
 Glu Glu Ala Leu Cys Leu Gly Glu Ala Leu Asn Cys Gly Gln Ala Leu
     210                 215                 220                
 Asn Cys Asp Glu Ala Leu Cys Ser Glu Glu Ala Leu Cys Ser Leu Gln
 225                 230                 235                 240
 Gln Met Leu Val Glu Glu Trp Met Asn Gly Pro Asn Cys Ile Ile Gly
                 245                 250                 255    
 Cys Lys Gly Arg Arg Ile Pro Asn Asp Val Leu Ala Ser Glu Met Arg
             260                 265                 270        
 Asn Gln Glu Arg Arg Pro Gly Asp Arg Glu Leu Gln Val Val Phe Glu
         275                 280                 285            
 Ile Cys Ser Val Leu Lys Pro Lys Cys Asp Glu Val Lys Arg Asn Ser
     290                 295                 300                
 His Ser Gly His Ser Arg Ile Thr Glu Pro Ala Ala Ser Ala Ser Glu
 305                 310                 315                 320
 Pro Ala Trp Gly Leu Pro Gly Ala His Ser Asp Leu Glu Val Ala Thr
                 325                 330                 335    
 Gly Ala Ala Gly Arg Arg Tyr Gly Cys Cys Pro Phe Phe Gln Lys Val
             340                 345                 350        
 His Pro Pro His Pro Gly Gly Ser Cys Ile Pro His Cys Ile Ser Gly
         355                 360                 365            
 Ala Gly Gln Pro Ala Pro Thr Lys Val Arg Met Leu Gln Gly Glu Gly
     370                 375                 380                
 Glu Ala Arg Val Ser Glu Thr Cys Arg Leu Gln Ile Gln Asp Thr Ala
 385                 390                 395                 400
 Ser Gln Lys Val Ile Phe Leu Phe His Phe Thr Ser Lys Leu Asn Tyr
                 405                 410                 415    





      <210> 1051
      <211> 234
      <212> PRT
      <213> Homo sapiens


      <400> 1051
 Met Glu Pro Ser Lys Thr Phe Met Arg Asn Leu Pro Ile Thr Pro Gly
   1               5                  10                  15    
 Tyr Ser Gly Phe Val Pro Phe Leu Ser Cys Gln Gly Met Ser Lys Glu
              20                  25                  30        
 Asp Asp Met Asn His Cys Val Lys Thr Phe Gln Glu Lys Thr Gln Arg
          35                  40                  45            
 Tyr Lys Glu Gln Leu Arg Glu Leu Cys Cys Ala Val Ala Thr Ala Pro
      50                  55                  60                
 Lys Leu Lys Pro Val Asn Ser Glu Glu Thr Val Leu Gln Ala Leu His
  65                  70                  75                  80
 Gln Tyr Asn Leu Gln Tyr His Pro Leu Ile Leu Glu Cys Lys Tyr Val
                  85                  90                  95    
 Lys Lys Pro Leu Gln Glu Pro Pro Ile Pro Gly Trp Ala Gly Tyr Leu
             100                 105                 110        
 Pro Arg Ala Lys Val Thr Glu Phe Gly Cys Gly Thr Arg Tyr Thr Val
         115                 120                 125            
 Met Ala Lys Asn Cys Tyr Lys Asp Phe Leu Glu Ile Thr Glu Arg Ala
     130                 135                 140                
 Lys Lys Ala His Leu Lys Pro Tyr Glu Glu Ile Tyr Gly Val Ser Ser
 145                 150                 155                 160
 Thr Lys Thr Ser Ala Pro Ser Pro Lys Val Leu Gln His Glu Glu Leu
                 165                 170                 175    
 Leu Pro Lys Tyr Pro Asp Phe Ser Ile Pro Asp Gly Ser Cys Pro Ala
             180                 185                 190        
 Leu Gly Arg Pro Leu Arg Glu Asp Pro Lys Thr Pro Leu Thr Cys Gly
         195                 200                 205            
 Cys Ala Gln Arg Pro Ser Ile Pro Cys Ser Gly Lys Met Tyr Leu Glu
     210                 215                 220                
 Pro Leu Ser Ser Ala Lys Tyr Ala Glu Gly
 225                 230                



      <210> 1052
      <211> 81
      <212> PRT
      <213> Homo sapiens


      <400> 1052
 Met Arg Arg Lys Glu Leu Gln Pro Phe Gly Glu Pro Arg Pro Arg Gly
   1               5                  10                  15    
 Ser Pro Ser Glu Gly Cys Asp Thr Ile Phe Gly Ala Pro Gln Ser Leu
              20                  25                  30        
 Ala Ser Pro Ser Phe Gln Ala Pro Pro Cys Ser Gln Val Pro Thr Leu
          35                  40                  45            
 Glu Ala Ala Cys Gly Thr Pro Asp Pro Ala Thr Ala Ser His Gly Ala
      50                  55                  60                
 Gly Thr Cys Thr Ser Ile Trp Gly Cys Leu Pro Cys Cys Ser Arg His
  65                  70                  75                  80
 Thr
    



      <210> 1053
      <211> 206
      <212> PRT
      <213> Homo sapiens


      <400> 1053
 Met Gly Cys Ser Gly Val Leu Lys Lys Arg Ile Val Leu Met Ser Ser
   1               5                  10                  15    
 Ile Leu Pro Lys Glu Val Asn Leu Ala Leu Ala Ala Asp Lys Val Gln
              20                  25                  30        
 Arg Phe Leu Ser Gly His Glu Ser Arg Arg Cys Gln Trp Leu Gly Leu
          35                  40                  45            
 Pro Leu Ser Gly Arg Ala Val Glu Trp Arg Thr Glu Ala Leu Glu Pro
      50                  55                  60                
 Ala Leu Leu Leu Pro Val Phe Lys Asn Ile Lys Thr Val Met Lys Ala
  65                  70                  75                  80
 Phe Glu Leu Ile Asp Val Asn Lys Thr Gly Leu Val Arg Pro Gln Glu
                  85                  90                  95    
 Leu Arg Arg Val Leu Glu Thr Phe Cys Met Lys Leu Arg Asp Glu Glu
             100                 105                 110        
 Tyr Glu Lys Phe Ser Lys His Tyr Asn Ile His Lys Asp Thr Ala Val
         115                 120                 125            
 Asp Tyr Asn Val Phe Leu Lys Asn Leu Ser Ile Asn Asn Asp Leu Asn
     130                 135                 140                
 Leu Arg Tyr Cys Met Gly Asn Gln Glu Val Ser Leu Glu Asn Gln Gln
 145                 150                 155                 160
 Ala Lys Asn Ser Lys Lys Glu Arg Leu Leu Gly Ser Ala Ser Ser Glu
                 165                 170                 175    
 Asp Ile Trp Arg Asn Tyr Ser Leu Asp Glu Ile Glu Arg Asn Phe Cys
             180                 185                 190        
 Leu Gln Val Arg Cys Phe Pro Lys Pro Gln Leu Pro Thr Glu
         195                 200                 205    



      <210> 1054
      <211> 92
      <212> PRT
      <213> Homo sapiens


      <400> 1054
 Met Gln Pro Gly Gly Thr Ala Gly Leu Gln Ser Arg His Glu Gly Gly
   1               5                  10                  15    
 Arg Gly Arg Gln Pro Gln Val Gly Leu Ser Arg Pro Thr Cys Gly Leu
              20                  25                  30        
 Pro Ala Ser Ser Pro Gly Pro Ala Leu Pro Pro Gly Cys Val Ser Arg
          35                  40                  45            
 Pro Asp Cys Cys Leu Pro Thr Thr Ser Leu Asp Ser Ala Pro Ala His
      50                  55                  60                
 Leu Leu Ala Ala Leu Val Gly Pro Gln Leu Pro Gln Ala Lys Leu Pro
  65                  70                  75                  80
 Arg Pro Arg Ser Gly Leu Thr Val Ala Ser Pro Gly
                  85                  90        



      <210> 1055
      <211> 450
      <212> PRT
      <213> Homo sapiens


      <400> 1055
 Met Ser Leu Arg Leu Ser Ser Ala Ser Arg Arg Ser Cys Pro Arg Pro
   1               5                  10                  15    
 Thr Thr Gly Ser Leu Arg Leu Tyr Gly Gly Gly Thr Ser Phe Gly Thr
              20                  25                  30        
 Gly Asn Ser Cys Gly Ile Ser Gly Ile Gly Ser Gly Phe Ser Ser Ala
          35                  40                  45            
 Phe Gly Gly Ser Ser Ser Gly Gly Asn Thr Gly Gly Gly Asn Pro Cys
      50                  55                  60                
 Ala Ala Phe Thr Val Asn Glu Arg Gly Leu Leu Ser Gly Asn Glu Lys
  65                  70                  75                  80
 Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr Leu Asp Ser
                  85                  90                  95    
 Val His Ala Leu Glu Glu Ala Asn Ala Asp Leu Glu Gln Lys Ile Lys
             100                 105                 110        
 Gly Trp Tyr Glu Lys Phe Gly Pro Gly Ser Cys Arg Gly Leu Asp His
         115                 120                 125            
 Asp Tyr Ser Arg Tyr Phe Pro Ile Ile Asp Asp Leu Lys Asn Gln Ile
     130                 135                 140                
 Ile Ala Ser Thr Thr Ser Asn Ala Asn Ala Val Leu Gln Ile Asp Asn
 145                 150                 155                 160
 Ala Arg Leu Thr Ala Asp Asp Phe Arg Leu Lys Tyr Glu Asn Glu Leu
                 165                 170                 175    
 Ala Leu His Gln Ser Val Glu Ala Asp Val Asn Gly Leu Arg Arg Val
             180                 185                 190        
 Leu Asp Glu Ile Thr Leu Cys Arg Thr Asp Leu Glu Ile Gln Tyr Glu
         195                 200                 205            
 Thr Leu Ser Glu Glu Met Thr Tyr Leu Lys Lys Asn His Lys Glu Glu
     210                 215                 220                
 Met Gln Val Leu Gln Cys Ala Ala Gly Gly Asn Val Asn Val Glu Met
 225                 230                 235                 240
 Asn Ala Ala Pro Gly Val Asp Leu Thr Val Leu Leu Asn Asn Met Arg
                 245                 250                 255    
 Ala Glu Tyr Glu Ala Leu Ala Glu Gln Asn Arg Arg Asp Ala Glu Ala
             260                 265                 270        
 Trp Phe Asn Glu Lys Ser Ala Ser Leu Gln Gln Gln Ile Ser Glu Asp
         275                 280                 285            
 Val Gly Ala Thr Thr Ser Ala Arg Asn Glu Leu Thr Glu Met Lys Arg
     290                 295                 300                
 Thr Leu Gln Thr Leu Glu Ile Glu Leu Gln Ser Leu Leu Ala Thr Lys
 305                 310                 315                 320
 His Ser Leu Glu Cys Ser Leu Thr Glu Thr Glu Ser Asn Tyr Cys Ala
                 325                 330                 335    
 Gln Leu Ala Gln Ile Gln Ala Gln Ile Gly Ala Leu Glu Glu Gln Leu
             340                 345                 350        
 His Gln Val Arg Thr Glu Thr Glu Gly Gln Lys Leu Glu Tyr Glu Gln
         355                 360                 365            
 Leu Leu Asp Ile Lys Leu His Leu Glu Lys Glu Ile Glu Thr Tyr Cys
     370                 375                 380                
 Leu Leu Ile Gly Gly Asp Asp Gly Ala Cys Lys Ser Gly Gly Tyr Lys
 385                 390                 395                 400
 Ser Lys Asp Tyr Gly Ser Gly Asn Val Gly Ser Gln Val Lys Asp Pro
                 405                 410                 415    
 Ala Lys Ala Ile Val Val Lys Lys Val Leu Glu Glu Val Asp Gln Arg
             420                 425                 430        
 Ser Lys Ile Leu Thr Thr Arg Leu His Ser Leu Glu Glu Lys Ser Gln
         435                 440                 445            
 Ser Asn
     450



      <210> 1056
      <211> 454
      <212> PRT
      <213> Homo sapiens


      <400> 1056
 Met Ser Leu Arg Leu Ser Ser Ala Ser Arg Arg Ser Cys Pro Arg Pro
   1               5                  10                  15    
 Thr Thr Gly Ser Leu Arg Leu Tyr Gly Gly Gly Thr Ser Phe Gly Thr
              20                  25                  30        
 Gly Asn Ser Cys Gly Ile Ser Gly Ile Gly Ser Gly Phe Ser Ser Ala
          35                  40                  45            
 Phe Gly Gly Ser Ser Ser Gly Gly Asn Thr Gly Gly Gly Asn Pro Cys
      50                  55                  60                
 Ala Ala Phe Thr Val Asn Glu Arg Gly Leu Leu Ser Gly Asn Glu Lys
  65                  70                  75                  80
 Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr Leu Asp Ser
                  85                  90                  95    
 Val His Ala Leu Glu Glu Ala Asn Ala Asp Leu Glu Gln Lys Ile Lys
             100                 105                 110        
 Gly Trp Tyr Glu Lys Phe Gly Pro Gly Ser Cys Arg Gly Leu Asp His
         115                 120                 125            
 Asp Tyr Ser Arg Tyr Phe Pro Ile Ile Asp Asp Leu Lys Asn Gln Ile
     130                 135                 140                
 Ile Ala Ser Thr Thr Ser Asn Ala Asn Ala Val Leu Gln Ile Asp Asn
 145                 150                 155                 160
 Ala Arg Leu Thr Ala Asp Asp Phe Arg Leu Lys Tyr Glu Asn Glu Leu
                 165                 170                 175    
 Ala Leu His Gln Ser Val Glu Ala Asp Val Asn Gly Leu Arg Arg Val
             180                 185                 190        
 Leu Asp Glu Ile Thr Leu Cys Arg Thr Asp Leu Glu Ile Gln Tyr Glu
         195                 200                 205            
 Thr Leu Ser Glu Glu Met Thr Tyr Leu Lys Lys Asn His Lys Glu Glu
     210                 215                 220                
 Met Gln Val Leu Gln Cys Ala Ala Gly Gly Asn Val Asn Val Glu Met
 225                 230                 235                 240
 Asn Ala Ala Pro Gly Val Asp Leu Thr Val Leu Leu Asn Asn Met Arg
                 245                 250                 255    
 Ala Glu Tyr Glu Ala Leu Ala Glu Gln Asn Arg Arg Asp Ala Glu Ala
             260                 265                 270        
 Trp Phe Asn Glu Lys Ser Ala Ser Leu Gln Gln Gln Ile Ser Asp Asp
         275                 280                 285            
 Ala Gly Ala Thr Thr Ser Ala Arg Asn Glu Leu Thr Glu Met Lys Arg
     290                 295                 300                
 Thr Leu Gln Thr Leu Glu Ile Glu Leu Gln Ser Leu Leu Ala Thr Lys
 305                 310                 315                 320
 His Ser Leu Glu Cys Ser Leu Thr Glu Thr Glu Ser Asn Tyr Cys Ala
                 325                 330                 335    
 Gln Leu Ala Gln Ile Gln Ala Gln Ile Gly Ala Leu Glu Glu Gln Leu
             340                 345                 350        
 His Gln Val Arg Thr Glu Thr Glu Gly Gln Lys Leu Glu Tyr Glu Gln
         355                 360                 365            
 Leu Leu Asp Ile Lys Val His Leu Glu Lys Glu Ile Glu Thr Tyr Cys
     370                 375                 380                
 Leu Leu Ile Asp Gly Glu Asp Gly Ser Cys Ser Lys Ser Lys Gly Tyr
 385                 390                 395                 400
 Gly Gly Pro Gly Asn Gln Thr Lys Asp Ser Ser Lys Thr Thr Ile Val
                 405                 410                 415    
 Lys Thr Val Val Glu Glu Ile Asp Pro Arg Gly Lys Val Leu Ser Ser
             420                 425                 430        
 Arg Val His Thr Val Glu Glu Lys Ser Thr Lys Val Asn Asn Lys Asn
         435                 440                 445            
 Glu Gln Arg Val Ser Ser
     450                



      <210> 1057
      <211> 238
      <212> PRT
      <213> Homo sapiens


      <400> 1057
 Met Thr Asp Leu Leu Arg Ser Val Val Thr Val Ile Asp Val Phe Tyr
   1               5                  10                  15    
 Lys Tyr Thr Lys Gln Asp Gly Glu Cys Gly Thr Leu Ser Lys Gly Glu
              20                  25                  30        
 Leu Lys Glu Leu Leu Glu Lys Glu Leu His Pro Val Leu Lys Asn Pro
          35                  40                  45            
 Asp Asp Pro Asp Thr Val Asp Val Ile Met His Met Leu Asp Arg Asp
      50                  55                  60                
 His Asp Arg Arg Leu Asp Phe Thr Glu Phe Leu Leu Met Ile Phe Lys
  65                  70                  75                  80
 Leu Thr Met Ala Cys Asn Lys Val Leu Ser Lys Glu Tyr Cys Lys Ala
                  85                  90                  95    
 Ser Gly Ser Lys Lys His Arg Arg Gly His Arg His Gln Glu Glu Glu
             100                 105                 110        
 Ser Glu Thr Glu Glu Asp Glu Glu Asp Thr Pro Gly His Lys Ser Gly
         115                 120                 125            
 Tyr Arg His Ser Ser Trp Ser Glu Gly Glu Glu His Gly Tyr Ser Ser
     130                 135                 140                
 Gly His Ser Arg Gly Thr Val Lys Cys Arg His Gly Ser Asn Ser Arg
 145                 150                 155                 160
 Arg Leu Gly Arg Gln Gly Asn Leu Ser Ser Ser Gly Asn Gln Glu Gly
                 165                 170                 175    
 Ser Gln Lys Arg Tyr His Arg Ser Ser Cys Gly His Ser Trp Ser Gly
             180                 185                 190        
 Gly Lys Asp Arg His Gly Ser Ser Ser Val Glu Leu Arg Glu Arg Ile
         195                 200                 205            
 Asn Lys Ser His Ile Ser Pro Ser Arg Glu Ser Gly Glu Glu Tyr Glu
     210                 215                 220                
 Ser Gly Ser Gly Ser Asn Ser Trp Glu Arg Lys Gly His Gly
 225                 230                 235            



      <210> 1058
      <211> 666
      <212> PRT
      <213> Homo sapiens


      <400> 1058
 Met Val Ser Ala Lys Ile Thr Gln Ala Lys Leu Gln Val Pro Gly Gly
   1               5                  10                  15    
 Asp Ser Asp Glu Asp Ser Lys Thr Pro Ser Ala Ser Pro Arg His Gly
              20                  25                  30        
 Arg Ser Arg Pro Ser Ser Ser Ile Gln Glu Ser Ser Ser Glu Ser Glu
          35                  40                  45            
 Asp Gly Asp Ala Arg Gly Glu Ile Phe Asp Ile Tyr Val Val Thr Ala
      50                  55                  60                
 Asp Tyr Leu Pro Leu Gly Ala Glu Gln Asp Ala Ile Thr Leu Arg Glu
  65                  70                  75                  80
 Gly Gln Tyr Val Glu Val Leu Asp Ala Ala His Pro Leu Arg Trp Leu
                  85                  90                  95    
 Val Arg Thr Lys Pro Thr Lys Ser Ser Pro Ser Arg Gln Gly Trp Val
             100                 105                 110        
 Ser Pro Ala Tyr Leu Asp Arg Arg Leu Lys Leu Ser Pro Glu Trp Gly
         115                 120                 125            
 Ala Ala Glu Ala Pro Glu Phe Pro Gly Glu Ala Val Ser Glu Asp Glu
     130                 135                 140                
 Tyr Lys Ala Arg Leu Ser Ser Val Ile Gln Glu Leu Leu Ser Ser Glu
 145                 150                 155                 160
 Gln Ala Phe Val Glu Glu Leu Gln Phe Leu Gln Ser His His Leu Gln
                 165                 170                 175    
 His Leu Glu Arg Cys Pro His Val Pro Ile Ala Val Ala Gly Gln Lys
             180                 185                 190        
 Ala Val Ile Phe Arg Asn Val Arg Asp Ile Gly Arg Phe His Ser Ser
         195                 200                 205            
 Phe Leu Gln Glu Leu Gln Gln Cys Asp Thr Asp Asp Asp Val Ala Met
     210                 215                 220                
 Cys Phe Ile Lys Asn Gln Ala Ala Phe Glu Gln Tyr Leu Glu Phe Leu
 225                 230                 235                 240
 Val Gly Arg Val Gln Ala Glu Ser Val Val Val Ser Thr Ala Ile Gln
                 245                 250                 255    
 Glu Phe Tyr Lys Lys Tyr Ala Glu Glu Ala Leu Leu Ala Gly Asp Pro
             260                 265                 270        
 Ser Gln Pro Pro Pro Pro Pro Leu Gln His Tyr Leu Glu Gln Pro Val
         275                 280                 285            
 Glu Arg Val Gln Arg Tyr Gln Ala Leu Leu Lys Glu Leu Ile Arg Asn
     290                 295                 300                
 Lys Ala Arg Asn Arg Gln Asn Cys Ala Leu Leu Glu Gln Ala Tyr Ala
 305                 310                 315                 320
 Val Val Ser Ala Leu Pro Gln Arg Ala Glu Asn Lys Leu His Val Ser
                 325                 330                 335    
 Leu Met Glu Asn Tyr Pro Gly Thr Leu Glu Ala Leu Gly Glu Pro Ile
             340                 345                 350        
 Arg Gln Gly His Phe Ile Val Trp Glu Gly Ala Pro Gly Ala Arg Met
         355                 360                 365            
 Pro Trp Lys Gly His Asn Arg His Val Phe Leu Phe Arg Asn His Leu
     370                 375                 380                
 Val Ile Cys Lys Pro Arg Arg Asp Ser Arg Thr Asp Thr Val Ser Tyr
 385                 390                 395                 400
 Val Phe Arg Asn Met Met Lys Leu Ser Ser Ile Asp Leu Asn Asp Gln
                 405                 410                 415    
 Val Glu Gly Asp Asp Arg Ala Phe Glu Val Trp Gln Glu Arg Glu Asp
             420                 425                 430        
 Ser Val Arg Lys Tyr Leu Leu Gln Ala Arg Thr Ala Ile Ile Lys Ser
         435                 440                 445            
 Ser Trp Val Lys Glu Ile Cys Gly Ile Gln Gln Arg Leu Ala Leu Pro
     450                 455                 460                
 Val Trp Arg Pro Pro Asp Phe Glu Glu Glu Leu Ala Asp Cys Thr Ala
 465                 470                 475                 480
 Glu Leu Gly Glu Thr Val Lys Leu Ala Cys Arg Val Thr Gly Thr Pro
                 485                 490                 495    
 Lys Pro Val Ile Ser Trp Tyr Lys Asp Gly Lys Ala Val Gln Val Asp
             500                 505                 510        
 Pro His His Ile Leu Ile Glu Asp Pro Asp Gly Ser Cys Ala Leu Ile
         515                 520                 525            
 Leu Asp Ser Leu Thr Gly Val Asp Ser Gly Gln Tyr Met Cys Phe Ala
     530                 535                 540                
 Ala Ser Ala Ala Gly Asn Cys Ser Thr Leu Gly Lys Ile Leu Val Gln
 545                 550                 555                 560
 Val Pro Pro Arg Phe Val Asn Lys Val Arg Ala Ser Pro Phe Val Glu
                 565                 570                 575    
 Gly Glu Asp Ala Gln Phe Thr Cys Thr Ile Glu Gly Ala Pro Tyr Pro
             580                 585                 590        
 Gln Thr Arg Trp Tyr Lys Asp Gly Ala Leu Leu Thr Thr Gly Asn Lys
         595                 600                 605            
 Phe Gln Thr Leu Ser Glu Pro Arg Ser Gly Leu Leu Val Leu Val Ile
     610                 615                 620                
 Arg Ala Ala Ser Lys Glu Asp Leu Gly Leu Tyr Glu Cys Glu Val Arg
 625                 630                 635                 640
 Ser Ala Gly Val Gly Thr Gly Leu Gly Thr Gln Ala Ile Leu Ala Gly
                 645                 650                 655    
 His Pro Leu Gly Ser Asp Cys Gly Gly Ala
             660                 665    



      <210> 1059
      <211> 443
      <212> PRT
      <213> Homo sapiens


      <400> 1059
 Met Gln Arg Ser Ile Met Ser Phe Phe His Pro Lys Lys Glu Gly Lys
   1               5                  10                  15    
 Ala Lys Lys Pro Glu Lys Glu Ala Ser Asn Ser Ser Arg Glu Thr Glu
              20                  25                  30        
 Pro Pro Pro Lys Ala Ala Leu Lys Glu Trp Asn Gly Val Val Ser Glu
          35                  40                  45            
 Ser Asp Ser Pro Val Lys Arg Pro Gly Arg Lys Ala Ala Arg Val Leu
      50                  55                  60                
 Gly Ser Glu Gly Glu Glu Glu Asp Glu Ala Leu Ser Pro Ala Lys Gly
  65                  70                  75                  80
 Gln Lys Pro Ala Leu Asp Cys Ser Gln Val Ser Pro Pro Arg Pro Ala
                  85                  90                  95    
 Thr Ser Pro Glu Asn Asn Ala Ser Leu Ser Asp Thr Ser Pro Met Asp
             100                 105                 110        
 Ser Ser Pro Ser Gly Ile Pro Lys Arg Arg Thr Ala Arg Lys Gln Leu
         115                 120                 125            
 Pro Lys Arg Thr Ile Gln Glu Val Leu Glu Glu Gln Ser Glu Asp Glu
     130                 135                 140                
 Asp Arg Glu Ala Lys Arg Lys Lys Glu Glu Glu Glu Glu Glu Thr Pro
 145                 150                 155                 160
 Lys Glu Ser Leu Thr Glu Ala Glu Val Ala Thr Glu Lys Glu Gly Glu
                 165                 170                 175    
 Asp Gly Asp Gln Pro Thr Thr Pro Pro Lys Pro Leu Lys Thr Ser Lys
             180                 185                 190        
 Ala Glu Thr Pro Thr Glu Ser Val Ser Glu Pro Glu Val Ala Thr Lys
         195                 200                 205            
 Gln Glu Leu Gln Glu Glu Glu Glu Gln Thr Lys Pro Pro Arg Arg Ala
     210                 215                 220                
 Pro Lys Thr Leu Ser Ser Phe Phe Thr Pro Arg Lys Pro Ala Val Lys
 225                 230                 235                 240
 Lys Glu Val Lys Glu Glu Glu Pro Gly Ala Pro Gly Lys Glu Gly Ala
                 245                 250                 255    
 Ala Glu Gly Pro Leu Asp Pro Ser Gly Tyr Asn Pro Ala Lys Asn Asn
             260                 265                 270        
 Tyr His Pro Val Glu Asp Ala Cys Trp Lys Pro Gly Gln Lys Val Pro
         275                 280                 285            
 Tyr Leu Ala Val Ala Arg Thr Phe Glu Lys Ile Glu Glu Val Ser Ala
     290                 295                 300                
 Arg Leu Arg Met Val Glu Thr Leu Ser Asn Leu Leu Arg Ser Val Val
 305                 310                 315                 320
 Ala Leu Ser Pro Pro Asp Leu Leu Pro Val Leu Tyr Leu Ser Leu Asn
                 325                 330                 335    
 His Leu Gly Pro Pro Gln Gln Gly Leu Glu Leu Gly Val Gly Asp Gly
             340                 345                 350        
 Val Leu Leu Lys Ala Val Ala Gln Ala Thr Gly Arg Gln Leu Glu Ser
         355                 360                 365            
 Val Arg Ala Glu Ala Ala Glu Lys Gly Asp Val Gly Leu Val Ala Glu
     370                 375                 380                
 Asn Ser Arg Arg His Pro Glu Ala His Ala Ala Thr Thr Ser Ala His
 385                 390                 395                 400
 Cys Leu Arg Gly Leu Gln Gln Val Pro Arg His Arg Gln Ala His Trp
                 405                 410                 415    
 Gln Cys Phe His Ser Gln Glu Asp Arg His His Gln Arg Pro Leu Cys
             420                 425                 430        
 Gly Leu Pro Pro Leu Arg Ser Pro Val His Arg
         435                 440            



      <210> 1060
      <211> 107
      <212> PRT
      <213> Homo sapiens


      <400> 1060
 Met Pro Ser Arg Phe Ser Leu Thr Gln Gly Gly Glu Ser Gln Ser Leu
   1               5                  10                  15    
 Ser Thr Trp Asn Ile Ser Thr His Ala Gly Leu Ser Gly Glu Asp Gln
              20                  25                  30        
 Val Thr Gln Ser Pro Glu Ala Leu Arg Leu Gln Glu Gly Glu Ser Ser
          35                  40                  45            
 Ser Leu Asn Cys Ser Tyr Thr Val Ser Gly Leu Arg Gly Leu Phe Trp
      50                  55                  60                
 Tyr Arg Gln Asp Pro Gly Lys Gly Pro Glu Phe Leu Phe Thr Leu Tyr
  65                  70                  75                  80
 Ser Ala Gly Glu Glu Lys Glu Lys Glu Arg Leu Lys Ala Thr Leu Thr
                  85                  90                  95    
 Lys Lys Glu Ser Phe Leu Ala His His Ser Pro
             100                 105        



      <210> 1061
      <211> 393
      <212> PRT
      <213> Homo sapiens


      <400> 1061
 Met Pro Asn Gln Gly Ser Leu Asn Ala Met Trp Tyr Ala Glu Val Lys
   1               5                  10                  15    
 Glu Leu Arg Glu Lys Ala Glu Phe Tyr Arg Lys Arg Val Gln Gly Thr
              20                  25                  30        
 His Phe Ser Arg Asp His Leu Asn Gln Ile Leu Ser Asp Ser Asn Cys
          35                  40                  45            
 Cys Trp Asp Val Ser Ser Thr Thr Ser Ser Glu Gly Thr Val Ser Ser
      50                  55                  60                
 Asn Ile Arg Ala Leu Asp Leu Ala Gly Asp Pro Thr Ser His Lys Thr
  65                  70                  75                  80
 Leu Gln Lys Cys Pro Ser Thr Glu Pro Glu Glu Lys Gly Asn Ile Val
                  85                  90                  95    
 Glu Glu Gln Pro Gln Lys Asn Thr Thr Glu Lys Leu Gly Val Ser Ala
             100                 105                 110        
 Pro Thr Ile Pro Val Arg Arg Arg Leu Ala Trp Asp Thr Glu Asn Thr
         115                 120                 125            
 Ser Glu Asp Val Gln Lys Gln Pro Gly Glu Lys Glu Glu Glu Asp Asp
     130                 135                 140                
 Asn Glu Glu Glu Gly Asp Arg Lys Thr Gly Lys Gln Ala Phe Met Gly
 145                 150                 155                 160
 Glu Gln Glu Lys Leu Asp Val His Glu Lys Ser Lys Ala Asp Lys Met
                 165                 170                 175    
 Lys Glu Gly Ser Asp Ser Ser Val Ser Ser Glu Lys Gly Gly Arg Leu
             180                 185                 190        
 Pro Thr Pro Lys Leu Arg Glu Leu Gly Gly Ile Gln Arg Thr His His
         195                 200                 205            
 Asp Leu Thr Thr Pro Ala Val Gly Gly Ala Val Leu Val Ser Pro Ser
     210                 215                 220                
 Lys Met Lys Pro Pro Ala Pro Glu Gln Arg Lys Arg Met Thr Ser Gln
 225                 230                 235                 240
 Asp Cys Leu Glu Thr Ser Lys Asn Asp Phe Thr Lys Lys Glu Ser Arg
                 245                 250                 255    
 Ala Val Ser Leu Leu Thr Ser Pro Ala Ala Gly Ile Lys Thr Val Asp
             260                 265                 270        
 Pro Leu Pro Leu Arg Glu Asp Ser Glu Asp Asn Ile His Lys Phe Ala
         275                 280                 285            
 Glu Ala Thr Leu Pro Val Ser Lys Ile Pro Lys Tyr Pro Thr Asn Pro
     290                 295                 300                
 Pro Gly Gln Leu Pro Ser Pro Pro His Val Pro Ser Tyr Trp His Pro
 305                 310                 315                 320
 Ser Arg Arg Ile Gln Gly Ser Leu Arg Asp Pro Glu Phe Gln His Asn
                 325                 330                 335    
 Val Gly Lys Ala Arg Met Asn Asn Leu Gln Leu Pro Gln His Glu Ala
             340                 345                 350        
 Phe Asn Asp Glu Asp Glu Asp Arg Leu Ser Glu Ile Ser Ala Arg Ser
         355                 360                 365            
 Ala Ala Ser Ser Leu Arg Ala Phe Gln Thr Leu Ala Arg Ala Lys Lys
     370                 375                 380                
 Arg Lys Glu Asn Phe Trp Gly Lys Thr
 385                 390            



      <210> 1062
      <211> 59
      <212> PRT
      <213> Homo sapiens


      <400> 1062
 Met Ala Ser Asn Arg Ala Ile Thr Leu Thr Ala Trp Pro Lys Ile Pro
   1               5                  10                  15    
 Phe Leu Gly Ile Cys Glu Ala Lys Asn Pro Arg Ser Glu Asn Met Arg
              20                  25                  30        
 Leu Ala Thr Ile Leu Glu Val Ala Cys His His Leu Gly Ser Ser Gly
          35                  40                  45            
 Ser Lys Asp Pro Leu Val Thr Val Val Asp Thr
      50                  55                



      <210> 1063
      <211> 259
      <212> PRT
      <213> Homo sapiens


      <400> 1063
 Met Ala Ser Pro Gln Gly Gly Gln Ile Ala Ile Ala Met Arg Leu Arg
   1               5                  10                  15    
 Asn Gln Leu Gln Ser Val Tyr Lys Met Asp Pro Leu Arg Asn Glu Glu
              20                  25                  30        
 Glu Val Arg Val Lys Ile Lys Asp Leu Asn Glu His Ile Val Cys Cys
          35                  40                  45            
 Leu Cys Ala Gly Tyr Phe Val Asp Ala Thr Thr Ile Thr Glu Cys Leu
      50                  55                  60                
 His Thr Phe Cys Lys Ser Cys Ile Val Lys Tyr Leu Gln Thr Ser Lys
  65                  70                  75                  80
 Tyr Cys Pro Met Cys Asn Ile Lys Ile His Glu Thr Gln Pro Leu Leu
                  85                  90                  95    
 Asn Leu Lys Leu Asp Arg Val Met Gln Asp Ile Val Tyr Lys Leu Val
             100                 105                 110        
 Pro Gly Leu Gln Asp Ser Glu Glu Lys Arg Ile Arg Glu Phe Tyr Gln
         115                 120                 125            
 Ser Arg Gly Leu Asp Arg Val Thr Gln Pro Thr Gly Glu Glu Pro Ala
     130                 135                 140                
 Leu Ser Asn Leu Gly Leu Pro Phe Ser Ser Phe Asp His Ser Lys Ala
 145                 150                 155                 160
 His Tyr Tyr Arg Tyr Asp Glu Gln Leu Asn Leu Cys Leu Glu Arg Leu
                 165                 170                 175    
 Ser Ser Gly Lys Asp Lys Asn Lys Ser Val Leu Gln Asn Lys Tyr Val
             180                 185                 190        
 Arg Cys Ser Val Arg Ala Glu Val Arg His Leu Arg Arg Val Leu Cys
         195                 200                 205            
 His Arg Leu Met Leu Asn Pro Gln His Val Gln Leu Leu Phe Asp Asn
     210                 215                 220                
 Glu Val Leu Pro Asp His Met Thr Met Lys Gln Ile Trp Leu Ser Arg
 225                 230                 235                 240
 Trp Phe Gly Lys Pro Ser Pro Leu Leu Leu Gln Tyr Ser Val Lys Glu
                 245                 250                 255    
 Lys Arg Arg
            



      <210> 1064
      <211> 757
      <212> PRT
      <213> Homo sapiens


      <400> 1064
 Met Ala Lys Arg Ser Ser Leu Tyr Ile Arg Ile Val Glu Gly Lys Asn
   1               5                  10                  15    
 Leu Pro Ala Lys Asp Ile Thr Gly Ser Ser Asp Pro Tyr Cys Ile Val
              20                  25                  30        
 Lys Val Asp Asn Glu Pro Ile Ile Arg Thr Ala Thr Val Trp Lys Thr
          35                  40                  45            
 Leu Cys Pro Phe Trp Gly Glu Glu Tyr Gln Val His Leu Pro Pro Thr
      50                  55                  60                
 Phe His Ala Val Ala Phe Tyr Val Met Asp Glu Asp Ala Leu Ser Arg
  65                  70                  75                  80
 Asp Asp Val Ile Gly Lys Val Cys Leu Thr Arg Asp Thr Ile Ala Ser
                  85                  90                  95    
 His Pro Lys Gly Phe Ser Gly Trp Ala His Leu Thr Glu Val Asp Pro
             100                 105                 110        
 Asp Glu Glu Val Gln Gly Glu Ile His Leu Arg Leu Glu Val Trp Pro
         115                 120                 125            
 Gly Ala Arg Ala Cys Arg Leu Arg Cys Ser Val Leu Glu Ala Arg Asp
     130                 135                 140                
 Leu Ala Pro Lys Asp Arg Asn Gly Thr Ser Asp Pro Phe Val Arg Val
 145                 150                 155                 160
 Arg Tyr Lys Gly Arg Thr Arg Glu Thr Ser Ile Val Lys Lys Ser Cys
                 165                 170                 175    
 Tyr Pro Arg Trp Asn Glu Thr Phe Glu Phe Glu Leu Gln Glu Gly Ala
             180                 185                 190        
 Met Glu Ala Leu Cys Val Glu Ala Trp Asp Trp Asp Leu Val Ser Arg
         195                 200                 205            
 Asn Asp Phe Leu Gly Lys Val Val Ile Asp Val Gln Arg Leu Arg Val
     210                 215                 220                
 Val Gln Gln Glu Glu Gly Trp Phe Arg Leu Gln Pro Asp Gln Ser Lys
 225                 230                 235                 240
 Ser Arg Arg His Asp Glu Gly Asn Leu Gly Ser Leu Gln Leu Glu Val
                 245                 250                 255    
 Arg Leu Arg Asp Glu Thr Val Leu Pro Ser Ser Tyr Tyr Gln Pro Leu
             260                 265                 270        
 Val His Leu Leu Cys His Glu Val Lys Leu Gly Met Gln Gly Pro Gly
         275                 280                 285            
 Gln Leu Ile Pro Leu Ile Glu Glu Thr Thr Ser Thr Glu Cys Arg Gln
     290                 295                 300                
 Asp Val Ala Thr Asn Leu Leu Lys Leu Phe Leu Gly Gln Gly Leu Ala
 305                 310                 315                 320
 Lys Asp Phe Leu Asp Leu Leu Phe Gln Leu Glu Leu Ser Arg Thr Ser
                 325                 330                 335    
 Glu Thr Asn Thr Leu Phe Arg Ser Asn Ser Leu Ala Ser Lys Ser Met
             340                 345                 350        
 Glu Ser Phe Leu Lys Val Ala Gly Met Gln Tyr Leu His Gly Val Leu
         355                 360                 365            
 Gly Pro Ile Ile Asn Lys Val Phe Glu Glu Lys Lys Tyr Val Glu Leu
     370                 375                 380                
 Asp Pro Ser Lys Val Glu Val Lys Asp Val Gly Cys Ser Gly Leu His
 385                 390                 395                 400
 Arg Pro Gln Thr Glu Ala Glu Val Leu Glu Gln Ser Ala Gln Thr Leu
                 405                 410                 415    
 Arg Ala His Leu Gly Ala Leu Leu Ser Ala Leu Ser Arg Ser Val Arg
             420                 425                 430        
 Ala Cys Pro Ala Val Val Arg Ala Thr Phe Arg Gln Leu Phe Arg Arg
         435                 440                 445            
 Val Arg Glu Arg Phe Pro Gly Ala Gln His Glu Asn Val Pro Phe Ile
     450                 455                 460                
 Ala Val Thr Ser Phe Leu Cys Leu Arg Phe Phe Ser Pro Ala Ile Met
 465                 470                 475                 480
 Ser Pro Lys Leu Phe His Leu Arg Glu Arg His Ala Asp Ala Arg Thr
                 485                 490                 495    
 Ser Arg Thr Leu Leu Leu Leu Ala Lys Ala Val Gln Asn Val Gly Asn
             500                 505                 510        
 Met Asp Thr Pro Ala Ser Arg Ala Lys Glu Ala Trp Met Glu Pro Leu
         515                 520                 525            
 Gln Pro Thr Val Arg Gln Gly Val Ala Gln Leu Lys Asp Phe Ile Thr
     530                 535                 540                
 Lys Leu Val Asp Ile Glu Glu Lys Asp Glu Leu Asp Leu Gln Arg Thr
 545                 550                 555                 560
 Leu Ser Leu Gln Ala Pro Pro Val Lys Glu Gly Pro Leu Phe Ile His
                 565                 570                 575    
 Arg Thr Lys Gly Lys Gly Pro Leu Met Ser Ser Ser Phe Lys Lys Leu
             580                 585                 590        
 Tyr Phe Ser Leu Thr Thr Glu Ala Leu Ser Phe Ala Lys Met Pro Ser
         595                 600                 605            
 Ser Lys Cys Val Asn Glu Leu Asn Gln Trp Leu Ser Ala Leu Arg Lys
     610                 615                 620                
 Val Ser Ile Asn Asn Thr Gly Leu Leu Gly Ser Tyr His Pro Gly Val
 625                 630                 635                 640
 Phe Arg Gly Asp Lys Trp Ser Cys Cys His Gln Lys Glu Lys Thr Gly
                 645                 650                 655    
 Gln Gly Cys Asp Lys Thr Arg Ser Arg Val Thr Leu Gln Glu Trp Asn
             660                 665                 670        
 Asp Pro Leu Asp His Asp Leu Glu Ala Gln Leu Ile Tyr Arg His Leu
         675                 680                 685            
 Leu Gly Val Glu Ala Met Leu Trp Glu Arg His Arg Glu Leu Ser Gly
     690                 695                 700                
 Gly Thr Glu Ala Gly Thr Val Pro Thr Ser Pro Gly Lys Val Pro Glu
 705                 710                 715                 720
 Asp Ser Leu Ala Arg Leu Leu Arg Val Leu Gln Asp Leu Arg Glu Ala
                 725                 730                 735    
 His Ser Ser Ser Pro Ala Gly Ser Pro Pro Ser Glu Pro Asn Cys Leu
             740                 745                 750        
 Leu Glu Leu Gln Thr
         755        



      <210> 1065
      <211> 515
      <212> PRT
      <213> Homo sapiens


      <400> 1065
 Met Gly Ala Gly Gln Ser Phe Asn Ser Gln Phe Leu Gln His Gly Gly
   1               5                  10                  15    
 Pro Arg Gly Pro Ser Val Pro Ala Gly Met Asn Pro Thr Gly Ile Gly
              20                  25                  30        
 Gly Val Met Gly Pro Ser Gly Leu Ser Pro Leu Ala Met Asn Pro Thr
          35                  40                  45            
 Arg Ala Ala Gly Met Thr Pro Leu Tyr Ala Gly Gln Arg Leu Pro Gln
      50                  55                  60                
 His Gly Tyr Pro Gly Pro Pro Gln Ala Gln Pro Leu Pro Arg Gln Gly
  65                  70                  75                  80
 Val Lys Arg Thr Tyr Ser Glu Val Tyr Pro Gly Gln Gln Tyr Leu Gln
                  85                  90                  95    
 Gly Gly Gln Tyr Ala Pro Ser Thr Ala Gln Phe Ala Pro Ser Pro Gly
             100                 105                 110        
 Gln Pro Pro Ala Pro Ser Pro Ser Tyr Pro Gly His Arg Leu Pro Leu
         115                 120                 125            
 Gln Gln Gly Met Thr Gln Ser Leu Ser Val Pro Gly Pro Thr Gly Leu
     130                 135                 140                
 His Tyr Lys Pro Thr Glu Gln Phe Asn Gly Gln Gly Ala Ser Phe Asn
 145                 150                 155                 160
 Gly Gly Ser Val Ser Tyr Ser Gln Pro Gly Leu Ser Gly Pro Thr Arg
                 165                 170                 175    
 Ser Ile Pro Gly Tyr Pro Ser Ser Pro Leu Pro Gly Asn Pro Thr Pro
             180                 185                 190        
 Pro Met Thr Pro Ser Ser Ser Val Pro Tyr Met Ser Pro Asn Gln Glu
         195                 200                 205            
 Val Lys Ser Pro Phe Leu Pro Asp Leu Lys Pro Asn Leu Asn Ser Leu
     210                 215                 220                
 His Ser Ser Pro Ser Gly Ser Gly Pro Cys Asp Glu Leu Arg Leu Thr
 225                 230                 235                 240
 Phe Pro Val Arg Asp Gly Val Val Leu Glu Pro Phe Arg Leu Gln His
                 245                 250                 255    
 Asn Leu Ala Val Ser Asn His Val Phe Gln Leu Arg Asp Ser Val Tyr
             260                 265                 270        
 Lys Thr Leu Ile Met Arg Pro Asp Leu Glu Leu Gln Phe Lys Cys Tyr
         275                 280                 285            
 His His Glu Asp Arg Gln Met Asn Thr Asn Trp Pro Ala Ser Val Gln
     290                 295                 300                
 Val Ser Val Asn Ala Thr Pro Leu Thr Ile Glu Arg Gly Asp Asn Lys
 305                 310                 315                 320
 Thr Ser His Lys Pro Leu Tyr Leu Lys His Val Cys Gln Pro Gly Arg
                 325                 330                 335    
 Asn Thr Ile Gln Ile Thr Val Thr Ala Cys Cys Cys Ser His Leu Phe
             340                 345                 350        
 Val Leu Gln Leu Val His Arg Pro Ser Val Arg Ser Val Leu Gln Gly
         355                 360                 365            
 Leu Leu Lys Lys Arg Leu Leu Pro Ala Glu His Cys Ile Thr Lys Ile
     370                 375                 380                
 Lys Arg Asn Phe Ser Ser Gly Thr Ile Pro Gly Thr Pro Gly Pro Asn
 385                 390                 395                 400
 Gly Glu Asp Gly Val Glu Gln Thr Ala Ile Lys Val Ser Leu Lys Cys
                 405                 410                 415    
 Pro Ile Thr Phe Arg Arg Ile Gln Leu Pro Ala Arg Gly His Asp Cys
             420                 425                 430        
 Arg His Ile Gln Cys Phe Asp Leu Glu Ser Tyr Leu Gln Leu Asn Cys
         435                 440                 445            
 Glu Arg Gly Thr Trp Arg Cys Pro Val Cys Asn Lys Thr Ala Leu Leu
     450                 455                 460                
 Glu Gly Leu Glu Val Asp Gln Tyr Met Leu Gly Ile Leu Ile Tyr Ile
 465                 470                 475                 480
 Gln Asn Ser Asp Tyr Glu Glu Ile Thr Ile Asp Pro Thr Cys Ser Trp
                 485                 490                 495    
 Lys Pro Val Pro Val Lys Pro Asp Met His Ile Lys Glu Glu Pro Asp
             500                 505                 510        
 Gly Pro His
         515



      <210> 1066
      <211> 247
      <212> PRT
      <213> Homo sapiens


      <400> 1066
 Met Ala Ser Glu Leu Cys Lys Thr Ile Ser Val Ala Arg Leu Glu Lys
   1               5                  10                  15    
 His Lys Asn Leu Phe Leu Asn Tyr Arg Asn Leu His His Phe Pro Leu
              20                  25                  30        
 Glu Leu Leu Lys Asp Glu Gly Leu Gln Tyr Leu Glu Arg Leu Tyr Met
          35                  40                  45            
 Lys Arg Asn Ser Leu Thr Ser Leu Pro Glu Asn Leu Ala Gln Lys Leu
      50                  55                  60                
 Pro Asn Leu Val Glu Leu Tyr Leu His Ser Asn Asn Ile Val Val Val
  65                  70                  75                  80
 Pro Glu Ala Ile Gly Ser Leu Val Lys Leu Gln Cys Leu Asp Leu Ser
                  85                  90                  95    
 Asp Asn Ala Leu Lys Ile Val Cys Pro Glu Ile Gly Arg Leu Arg Ala
             100                 105                 110        
 Leu Arg His Leu Arg Leu Ala Asn Asn Gln Leu Gln Phe Leu Pro Pro
         115                 120                 125            
 Glu Val Gly Asp Leu Lys Glu Leu Gln Thr Leu Asp Ile Ser Thr Asn
     130                 135                 140                
 Arg Leu Leu Thr Leu Pro Glu Arg Leu His Met Cys Leu Ser Leu Gln
 145                 150                 155                 160
 Tyr Leu Thr Val Asp Arg Asn Arg Leu Trp Tyr Val Pro Arg His Leu
                 165                 170                 175    
 Cys Gln Leu Pro Ser Leu Asn Glu Leu Ser Met Ala Gly Asn Arg Leu
             180                 185                 190        
 Ala Phe Leu Pro Leu Asp Leu Gly Arg Ser Arg Glu Leu Gln Tyr Val
         195                 200                 205            
 Tyr Val Asp Asn Asn Ile His Leu Lys Gly Leu Pro Ser Tyr Leu Tyr
     210                 215                 220                
 Asn Lys Val Ile Gly Cys Ser Gly Ser Thr Leu Phe Thr Val Gly Gly
 225                 230                 235                 240
 Asp Tyr Met Glu Ser Asp His
                 245        



      <210> 1067
      <211> 364
      <212> PRT
      <213> Homo sapiens


      <400> 1067
 Met Val Leu Ser Ser Val Thr Arg Ile Ser Phe Ala Gln Arg Gly Thr
   1               5                  10                  15    
 Pro Ala Gly Thr Ser Ser Pro Ala Ser Ser Ser Ser Leu Leu Asn Arg
              20                  25                  30        
 Leu Gln Leu Asp Asp Asp Ile Asp Gly Glu Thr Arg Asp Leu Phe Val
          35                  40                  45            
 Ile Val Asp Asp Pro Lys Lys His Val Cys Thr Met Glu Thr Tyr Ile
      50                  55                  60                
 Thr Tyr Arg Ile Thr Thr Lys Ser Thr Arg Val Glu Phe Asp Leu Pro
  65                  70                  75                  80
 Glu Tyr Ser Val Arg Arg Arg Tyr Gln Asp Phe Asp Trp Leu Arg Ser
                  85                  90                  95    
 Lys Leu Glu Glu Ser Gln Pro Thr His Leu Ile Ser Pro Leu Pro Glu
             100                 105                 110        
 Lys Phe Val Val Lys Gly Val Val Asp Arg Phe Ser Glu Glu Phe Val
         115                 120                 125            
 Glu Thr Arg Arg Lys Ala Leu Asp Lys Phe Leu Lys Arg Ile Thr Asp
     130                 135                 140                
 His Pro Val Leu Ser Phe Asn Glu His Phe Asn Ile Phe Leu Thr Ala
 145                 150                 155                 160
 Lys Asp Leu Asn Ala Tyr Lys Lys Gln Gly Ile Ala Leu Leu Thr Arg
                 165                 170                 175    
 Met Gly Glu Ser Val Lys His Val Thr Gly Gly Tyr Lys Leu Arg Thr
             180                 185                 190        
 Arg Pro Leu Glu Phe Ala Ala Ile Gly Asp Tyr Leu Asp Thr Phe Ala
         195                 200                 205            
 Leu Lys Leu Gly Thr Ile Asp Arg Ile Ala Gln Arg Ile Ile Lys Glu
     210                 215                 220                
 Glu Ile Glu Tyr Leu Val Glu Leu Arg Glu Tyr Gly Pro Val Tyr Ser
 225                 230                 235                 240
 Thr Trp Ser Ala Leu Glu Gly Glu Leu Ala Glu Pro Leu Glu Gly Val
                 245                 250                 255    
 Ser Ala Cys Ile Gly Asn Cys Ser Thr Ala Leu Glu Glu Leu Thr Asp
             260                 265                 270        
 Asp Met Thr Glu Asp Phe Leu Pro Val Leu Arg Glu Tyr Ile Leu Tyr
         275                 280                 285            
 Ser Asp Ser Met Lys Ser Val Leu Lys Lys Arg Asp Gln Val Gln Ala
     290                 295                 300                
 Glu Tyr Glu Ala Lys Leu Glu Ala Val Ala Leu Arg Lys Glu Asp Arg
 305                 310                 315                 320
 Pro Lys Val Pro Ala Asp Val Asp Lys Cys Gln Asp Arg Met Glu Cys
                 325                 330                 335    
 Phe Asn Ala Asp Leu Lys Ala Asp Met Glu Arg Trp Gln Asn Asn Lys
             340                 345                 350        
 Arg Gln Asp Phe Arg Pro Ala Thr His Ala Asp Gly
         355                 360                



      <210> 1068
      <211> 426
      <212> PRT
      <213> Homo sapiens


      <400> 1068
 Met Met Lys Ile Pro His Gln Thr Gln Lys Lys Arg Ser Leu Glu Asp
   1               5                  10                  15    
 Pro Asn Ser Arg Pro Arg Arg Arg Arg Ser Lys Met Ala Ala Thr Ala
              20                  25                  30        
 Ala Ala Val Val Ala Glu Glu Asp Thr Glu Leu Arg Asp Leu Leu Val
          35                  40                  45            
 Gln Thr Leu Glu Asn Ser Gly Val Leu Asn Arg Ile Lys Ala Glu Leu
      50                  55                  60                
 Arg Ala Ala Val Phe Leu Ala Leu Glu Glu Gln Glu Lys Val Glu Asn
  65                  70                  75                  80
 Lys Thr Pro Leu Val Asn Glu Ser Leu Lys Lys Phe Leu Asn Thr Lys
                  85                  90                  95    
 Asp Gly Arg Leu Val Ala Ser Leu Val Ala Glu Phe Leu Gln Phe Phe
             100                 105                 110        
 Asn Leu Asp Phe Thr Leu Ala Val Phe Gln Pro Glu Thr Ser Thr Leu
         115                 120                 125            
 Gln Gly Leu Glu Gly Arg Glu Asn Leu Ala Arg Asp Leu Gly Ile Ile
     130                 135                 140                
 Glu Ala Glu Gly Thr Val Gly Gly Pro Leu Leu Leu Glu Val Ile Arg
 145                 150                 155                 160
 Arg Cys Gln Gln Lys Glu Lys Gly Pro Thr Thr Gly Glu Gly Ala Leu
                 165                 170                 175    
 Asp Leu Ser Asp Val His Ser Pro Pro Lys Ser Pro Glu Gly Lys Thr
             180                 185                 190        
 Ser Ala Gln Thr Thr Pro Ser Lys Ile Pro Arg Tyr Lys Gly Gln Gly
         195                 200                 205            
 Lys Lys Lys Thr Ser Gly Gln Lys Ala Gly Asp Lys Lys Ala Asn Asp
     210                 215                 220                
 Glu Ala Asn Gln Ser Asp Thr Ser Val Ser Leu Ser Glu Pro Lys Ser
 225                 230                 235                 240
 Lys Ser Ser Leu His Leu Leu Ser His Glu Thr Lys Ile Val Ser Phe
                 245                 250                 255    
 Leu Ser Asn Arg Thr Leu Asp Gly Lys Asp Lys Ala Gly Leu Cys Pro
             260                 265                 270        
 Asp Glu Asp Asp Met Glu Gly Asp Ser Phe Phe Asp Asp Pro Ile Pro
         275                 280                 285            
 Lys Pro Glu Lys Thr Tyr Gly Leu Arg Lys Glu Pro Arg Lys Gln Ala
     290                 295                 300                
 Gly Ser Leu Ala Ser Leu Ser Asp Ala Pro Pro Leu Lys Ser Gly Leu
 305                 310                 315                 320
 Ser Ser Leu Ala Gly Ala Pro Ser Leu Lys Asp Ser Glu Ser Lys Arg
                 325                 330                 335    
 Gly Asn Thr Val Leu Lys Asp Leu Lys Leu Ile Ser Asp Lys Ile Gly
             340                 345                 350        
 Ser Leu Gly Leu Gly Thr Gly Glu Asp Asp Asp Tyr Val Asp Asp Phe
         355                 360                 365            
 Asn Ser Thr Ser His Arg Ser Glu Lys Ser Glu Ile Ser Ile Gly Glu
     370                 375                 380                
 Glu Ile Glu Glu Asp Leu Ser Val Glu Ile Asp Asp Ile Asn Thr Ser
 385                 390                 395                 400
 Asp Lys Leu Asp Asp Leu Thr Gln Asp Leu Thr Val Ser Gln Leu Ser
                 405                 410                 415    
 Asp Val Ala Asp Tyr Leu Glu Asp Val Ala
             420                 425    



      <210> 1069
      <211> 406
      <212> PRT
      <213> Homo sapiens


      <400> 1069
 Met Met Lys Ile Pro His Gln Thr Gln Lys Lys Arg Ser Leu Glu Asp
   1               5                  10                  15    
 Pro Asn Ser Arg Pro Arg Arg Arg Arg Ser Lys Met Ala Ala Thr Ala
              20                  25                  30        
 Ala Ala Val Val Ala Glu Glu Asp Thr Glu Leu Arg Asp Leu Leu Val
          35                  40                  45            
 Gln Thr Leu Glu Asn Ser Gly Val Leu Asn Arg Ile Lys Ala Glu Leu
      50                  55                  60                
 Arg Ala Ala Val Phe Leu Ala Leu Glu Glu Gln Glu Lys Val Glu Asn
  65                  70                  75                  80
 Lys Thr Pro Leu Val Asn Glu Ser Leu Lys Lys Phe Leu Asn Thr Lys
                  85                  90                  95    
 Asp Gly Arg Leu Val Ala Ser Leu Val Ala Glu Phe Leu Gln Phe Phe
             100                 105                 110        
 Asn Leu Asp Phe Thr Leu Ala Val Phe Gln Pro Glu Thr Ser Thr Leu
         115                 120                 125            
 Gln Gly Leu Glu Gly Arg Glu Asn Leu Ala Arg Asp Leu Gly Ile Ile
     130                 135                 140                
 Glu Ala Glu Gly Thr Val Gly Gly Pro Leu Leu Leu Glu Val Ile Arg
 145                 150                 155                 160
 Arg Cys Gln Gln Lys Glu Lys Gly Pro Thr Thr Gly Glu Gly Ala Leu
                 165                 170                 175    
 Asp Leu Ser Asp Val His Ser Pro Pro Lys Ser Pro Glu Gly Lys Thr
             180                 185                 190        
 Ser Ala Gln Thr Thr Pro Ser Lys Lys Ala Asn Asp Glu Ala Asn Gln
         195                 200                 205            
 Ser Asp Thr Ser Val Ser Leu Ser Glu Pro Lys Ser Lys Ser Ser Leu
     210                 215                 220                
 His Leu Leu Ser His Glu Thr Lys Ile Val Ser Phe Leu Ser Asn Arg
 225                 230                 235                 240
 Thr Leu Asp Gly Lys Asp Lys Ala Gly Leu Cys Pro Asp Glu Asp Asp
                 245                 250                 255    
 Met Glu Gly Asp Ser Phe Phe Asp Asp Pro Ile Pro Lys Pro Glu Lys
             260                 265                 270        
 Thr Tyr Gly Leu Arg Lys Glu Pro Arg Lys Gln Ala Gly Ser Leu Ala
         275                 280                 285            
 Ser Leu Ser Asp Ala Pro Pro Leu Lys Ser Gly Leu Ser Ser Leu Ala
     290                 295                 300                
 Gly Ala Pro Ser Leu Lys Asp Ser Glu Ser Lys Arg Gly Asn Thr Val
 305                 310                 315                 320
 Leu Lys Asp Leu Lys Leu Ile Ser Asp Lys Ile Gly Ser Leu Gly Leu
                 325                 330                 335    
 Gly Thr Gly Glu Asp Asp Asp Tyr Val Asp Asp Phe Asn Ser Thr Ser
             340                 345                 350        
 His Arg Ser Glu Lys Ser Glu Ile Ser Ile Gly Glu Glu Ile Glu Glu
         355                 360                 365            
 Asp Leu Ser Val Glu Ile Asp Asp Ile Asn Thr Ser Asp Lys Leu Asp
     370                 375                 380                
 Asp Leu Thr Gln Asp Leu Thr Val Ser Gln Leu Ser Asp Val Ala Asp
 385                 390                 395                 400
 Tyr Leu Glu Asp Val Ala
                 405    



      <210> 1070
      <211> 85
      <212> PRT
      <213> Homo sapiens


      <400> 1070
 Met Gln Thr Gly Leu Lys His Ala Pro Cys Ser Pro Tyr Cys Arg Gln
   1               5                  10                  15    
 Arg Arg Gln Lys Leu Gln Pro Phe Arg Glu Pro Arg Leu Gly Ser Ser
              20                  25                  30        
 Pro Arg His Gly Cys Asn Ser Leu Phe Gly Thr Leu Trp Phe Leu Ala
          35                  40                  45            
 Ser Pro Ser Phe Trp Val Pro Pro His Phe Pro Val Pro Ala Gly Glu
      50                  55                  60                
 Ala Val Cys Ser Ala Pro Gly Pro Ala Ala Ala Ser Gln Arg Ala Ser
  65                  70                  75                  80
 Ala His Ala Gly Thr
                  85



      <210> 1071
      <211> 327
      <212> PRT
      <213> Homo sapiens


      <400> 1071
 Met Arg Ile Pro Val Asp Pro Ser Thr Ser Arg Arg Phe Thr Pro Pro
   1               5                  10                  15    
 Ser Pro Ala Phe Pro Cys Gly Gly Gly Gly Gly Lys Met Gly Glu Asn
              20                  25                  30        
 Ser Gly Ala Leu Ser Ala Gln Ala Ala Val Gly Pro Gly Gly Arg Ala
          35                  40                  45            
 Arg Pro Glu Val Arg Ser Met Val Asp Val Leu Ala Asp His Ala Gly
      50                  55                  60                
 Glu Leu Val Arg Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro
  65                  70                  75                  80
 Ser His Trp Arg Cys Asn Lys Thr Leu Pro Val Ala Phe Lys Val Val
                  85                  90                  95    
 Ala Leu Gly Asp Val Pro Asp Gly Thr Val Val Thr Val Met Ala Gly
             100                 105                 110        
 Asn Asp Glu Asn Tyr Ser Ala Glu Leu Arg Asn Ala Ser Ala Val Met
         115                 120                 125            
 Lys Asn Gln Val Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser
     130                 135                 140                
 Gly Arg Gly Thr Ser Glu Leu Asn Pro Phe Ser Asp Pro Arg Gln Phe
 145                 150                 155                 160
 Asp Arg Ser Phe Pro Thr Leu Pro Thr Leu Thr Glu Ser Arg Phe Pro
                 165                 170                 175    
 Asp Pro Arg Met His Tyr Pro Gly Ala Met Ser Ala Ala Phe Pro Tyr
             180                 185                 190        
 Ser Ala Thr Pro Ser Gly Thr Ser Ile Ser Ser Leu Ser Val Ala Gly
         195                 200                 205            
 Met Pro Ala Thr Ser Arg Phe His His Thr Tyr Leu Pro Pro Pro Tyr
     210                 215                 220                
 Pro Gly Ala Pro Gln Asn Gln Ser Gly Pro Phe Gln Ala Asn Pro Ser
 225                 230                 235                 240
 Pro Tyr His Leu Tyr Tyr Gly Thr Ser Ser Gly Ser Tyr Gln Phe Ser
                 245                 250                 255    
 Met Val Ala Gly Ser Ser Ser Gly Gly Asp Arg Ser Pro Thr Arg Met
             260                 265                 270        
 Leu Ala Ser Cys Thr Ser Ser Ala Ala Ser Val Ala Ala Gly Asn Leu
         275                 280                 285            
 Met Asn Pro Ser Leu Gly Gly Gln Ser Asp Gly Val Glu Ala Asp Gly
     290                 295                 300                
 Ser His Ser Asn Ser Pro Thr Ala Leu Ser Thr Pro Gly Arg Met Asp
 305                 310                 315                 320
 Glu Ala Val Trp Arg Pro Tyr
                 325        



      <210> 1072
      <211> 447
      <212> PRT
      <213> Homo sapiens


      <400> 1072
 Met Ser Asn Ser His Pro Leu Arg Pro Phe Thr Ala Val Gly Glu Ile
   1               5                  10                  15    
 Asp His Val His Ile Leu Ser Glu His Ile Gly Ala Leu Leu Ile Gly
              20                  25                  30        
 Glu Glu Tyr Gly Asp Val Thr Phe Val Val Glu Lys Lys Arg Phe Pro
          35                  40                  45            
 Ala His Arg Val Ile Leu Ala Ala Arg Cys Gln Tyr Phe Arg Ala Leu
      50                  55                  60                
 Leu Tyr Gly Gly Met Arg Glu Ser Gln Pro Glu Ala Glu Ile Pro Leu
  65                  70                  75                  80
 Gln Asp Thr Thr Ala Glu Ala Phe Thr Met Leu Leu Lys Tyr Ile Tyr
                  85                  90                  95    
 Thr Gly Arg Ala Thr Leu Thr Asp Glu Lys Glu Glu Val Leu Leu Asp
             100                 105                 110        
 Phe Leu Ser Leu Ala His Lys Tyr Gly Phe Pro Glu Leu Glu Asp Ser
         115                 120                 125            
 Thr Ser Glu Tyr Leu Cys Thr Ile Leu Asn Ile Gln Asn Val Cys Met
     130                 135                 140                
 Thr Phe Asp Val Ala Ser Leu Tyr Ser Leu Pro Lys Leu Thr Cys Met
 145                 150                 155                 160
 Cys Cys Met Phe Met Asp Arg Asn Ala Gln Glu Val Leu Ser Ser Glu
                 165                 170                 175    
 Gly Phe Leu Ser Leu Ser Lys Thr Ala Leu Leu Asn Ile Val Leu Arg
             180                 185                 190        
 Asp Ser Phe Ala Ala Pro Glu Lys Asp Ile Phe Leu Ala Leu Leu Asn
         195                 200                 205            
 Trp Cys Lys His Asn Ser Lys Glu Asn His Ala Glu Ile Met Gln Ala
     210                 215                 220                
 Val Arg Leu Pro Leu Met Ser Leu Thr Glu Leu Leu Asn Val Val Arg
 225                 230                 235                 240
 Pro Ser Gly Leu Leu Ser Pro Asp Ala Ile Leu Asp Ala Ile Lys Val
                 245                 250                 255    
 Arg Ser Glu Ser Arg Asp Met Asp Leu Asn Tyr Arg Gly Met Leu Ile
             260                 265                 270        
 Pro Glu Glu Asn Ile Ala Thr Met Lys Tyr Gly Ala Gln Val Val Lys
         275                 280                 285            
 Gly Glu Leu Lys Ser Ala Leu Leu Asp Gly Asp Thr Gln Asn Tyr Asp
     290                 295                 300                
 Leu Asp His Gly Phe Ser Arg His Pro Ile Asp Asp Asp Cys Arg Ser
 305                 310                 315                 320
 Gly Ile Glu Ile Lys Leu Gly Gln Pro Ser Ile Ile Asn His Val Arg
                 325                 330                 335    
 Ile Leu Leu Trp Asp Arg Asp Ser Arg Ser Tyr Ser Tyr Phe Ile Glu
             340                 345                 350        
 Val Ser Met Asp Glu Leu Asp Trp Val Arg Val Ile Asp His Ser Gln
         355                 360                 365            
 Tyr Leu Cys Arg Ser Trp Gln Lys Leu Tyr Phe Pro Ala Arg Val Cys
     370                 375                 380                
 Arg Tyr Ile Arg Ile Val Gly Thr His Asn Thr Val Asn Lys Ile Phe
 385                 390                 395                 400
 His Ile Val Ala Phe Glu Cys Met Phe Thr Asn Lys Thr Phe Thr Leu
                 405                 410                 415    
 Glu Lys Gly Leu Ile Gly Tyr Tyr Phe Gly Ile Val Thr Leu Lys Val
             420                 425                 430        
 Asp Thr Val Glu His Leu Gly Glu Lys Arg Lys Arg Pro His Glu
         435                 440                 445        



      <210> 1073
      <211> 1154
      <212> PRT
      <213> Homo sapiens


      <400> 1073
 Met Phe Gly Leu Lys Pro Pro Leu Tyr Tyr Leu Pro Gly Ser Ser Leu
   1               5                  10                  15    
 Ser Ser Glu Ser Ser Pro Val Ser Ser Pro Ala Thr Asn His Ser Ser
              20                  25                  30        
 Pro Ala Ser Thr Pro Lys Arg Val Pro Met Gly Pro Ile Ile Val Pro
          35                  40                  45            
 Pro Gly Gly His Ser Val Pro Ser Thr Pro Pro Val Val Thr Ile Ala
      50                  55                  60                
 Pro Thr Lys Thr Val Asn Gly Val Trp Arg Ser Glu Ser Arg Gln Asp
  65                  70                  75                  80
 Ala Gly Pro Arg Ser Ser Ser Gly Gly Arg Glu Arg Leu Ile Val Glu
                  85                  90                  95    
 Pro Pro Leu Pro Gln Glu Lys Ala Gly Gly Pro Ala Ile Pro Ser His
             100                 105                 110        
 Leu Leu Ser Thr Pro Tyr Pro Phe Gly Leu Ser Pro Ser Ser Val Val
         115                 120                 125            
 Gln Asp Ser Arg Phe Pro Pro Leu Asn Leu Gln Arg Pro Val His His
     130                 135                 140                
 Val Val Pro Pro Ser Thr Val Thr Glu Asp Tyr Leu Arg Ser Phe Arg
 145                 150                 155                 160
 Pro Tyr His Thr Thr Asp Asp Leu Arg Met Ser Ser Leu Pro Pro Leu
                 165                 170                 175    
 Gly Leu Asp Pro Ala Thr Ala Ala Ala Tyr Tyr His Pro Ser Tyr Leu
             180                 185                 190        
 Ala Pro His Pro Phe Pro His Pro Ala Phe Arg Met Asp Asp Ser Tyr
         195                 200                 205            
 Cys Leu Ser Ala Leu Arg Ser Pro Phe Tyr Pro Ile Pro Thr Pro Gly
     210                 215                 220                
 Ser Leu Pro Pro Leu His Pro Ser Ala Met His Leu His Leu Ser Gly
 225                 230                 235                 240
 Val Arg Tyr Pro Pro Glu Leu Ser His Ser Ser Leu Ala Ala Leu His
                 245                 250                 255    
 Ser Glu Arg Met Ser Gly Leu Ser Ala Glu Arg Leu Gln Met Asp Glu
             260                 265                 270        
 Glu Leu Arg Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg
         275                 280                 285            
 Glu Ala Asp Arg Glu Arg Glu Lys Glu Arg Glu Arg Glu Arg Glu Lys
     290                 295                 300                
 Glu Arg Glu Gln Glu Lys Glu Arg Glu Arg Glu Lys Glu Arg Glu Arg
 305                 310                 315                 320
 Glu Leu Glu Arg Gln Arg Glu Gln Arg Ala Arg Glu Lys Glu Leu Leu
                 325                 330                 335    
 Ala Ala Lys Ala Leu Glu Pro Ser Phe Leu Pro Val Ala Glu Leu His
             340                 345                 350        
 Gly Leu Arg Gly His Ala Thr Glu Glu Arg Gly Lys Pro Ser Glu Gln
         355                 360                 365            
 Leu Thr Pro Thr Arg Ala Glu Lys Leu Lys Asp Ala Ser Leu Gln Ala
     370                 375                 380                
 Pro Lys Pro Val Gln His Pro Leu His Pro Val Pro Thr Pro His His
 385                 390                 395                 400
 Thr Val Pro Ser Leu Ile Ser Asn His Gly Ile Phe Ser Leu Pro Ser
                 405                 410                 415    
 Ser Ser Ala Ala Thr Ala Leu Leu Ile Gln Arg Thr Asn Glu Glu Glu
             420                 425                 430        
 Lys Trp Leu Ala Arg Gln Arg Arg Leu Arg Gln Glu Lys Glu Asp Arg
         435                 440                 445            
 Gln Ser Gln Val Ser Glu Phe Arg Gln Gln Val Leu Glu Gln His Leu
     450                 455                 460                
 Asp Met Gly Arg Pro Pro Val Pro Ala Glu Ala Glu His Arg Pro Glu
 465                 470                 475                 480
 Ser Thr Thr Arg Pro Gly Pro Asn Arg His Glu Pro Gly Gly Arg Asp
                 485                 490                 495    
 Pro Pro Gln His Phe Gly Gly Pro Pro Pro Leu Ile Ser Pro Lys Pro
             500                 505                 510        
 Gln Leu His Ala Ala Pro Thr Ala Leu Trp Asn Pro Val Ser Leu Met
         515                 520                 525            
 Asp Asn Thr Leu Glu Thr Arg Arg Ala Glu Ser His Ser Leu His Ser
     530                 535                 540                
 His Pro Ala Ala Phe Glu Pro Ser Arg Gln Ala Ala Val Pro Leu Val
 545                 550                 555                 560
 Lys Val Glu Arg Val Phe Cys Pro Glu Lys Ala Glu Glu Gly Pro Arg
                 565                 570                 575    
 Lys Arg Glu Pro Ala Pro Leu Asp Lys Tyr Gln Pro Pro Pro Pro Pro
             580                 585                 590        
 Pro Arg Glu Gly Gly Ser Leu Glu His Gln Pro Phe Leu Pro Gly Pro
         595                 600                 605            
 Gly Pro Phe Leu Ala Glu Leu Glu Lys Ser Thr Gln Thr Ile Leu Gly
     610                 615                 620                
 Gln Gln Arg Ala Ser Leu Pro Gln Ala Ala Thr Phe Gly Glu Leu Ser
 625                 630                 635                 640
 Gly Pro Leu Lys Pro Gly Ser Pro Tyr Arg Pro Pro Val Pro Arg Ala
                 645                 650                 655    
 Pro Asp Pro Ala Tyr Ile Tyr Asp Glu Phe Leu Gln Gln Arg Arg Arg
             660                 665                 670        
 Leu Val Ser Lys Leu Asp Leu Glu Glu Arg Arg Arg Arg Glu Ala Gln
         675                 680                 685            
 Glu Lys Gly Tyr Tyr Tyr Asp Leu Asp Asp Ser Tyr Asp Glu Ser Asp
     690                 695                 700                
 Glu Glu Glu Val Arg Ala His Leu Arg Cys Val Ala Glu Gln Pro Pro
 705                 710                 715                 720
 Leu Lys Leu Asp Thr Ser Ser Glu Lys Leu Glu Phe Leu Gln Leu Phe
                 725                 730                 735    
 Gly Leu Thr Thr Gln Gln Gln Lys Glu Glu Leu Val Ala Gln Lys Arg
             740                 745                 750        
 Arg Lys Arg Arg Arg Met Leu Arg Glu Arg Ser Pro Ser Pro Pro Thr
         755                 760                 765            
 Ile Gln Ser Lys Arg Gln Thr Pro Ser Pro Arg Leu Ala Leu Ser Thr
     770                 775                 780                
 Arg Tyr Ser Pro Asp Glu Met Asn Asn Ser Pro Asn Phe Glu Glu Lys
 785                 790                 795                 800
 Lys Lys Phe Leu Thr Ile Phe Asn Leu Thr His Ile Ser Ala Glu Lys
                 805                 810                 815    
 Arg Lys Asp Lys Glu Arg Leu Val Glu Met Leu Arg Ala Met Lys Gln
             820                 825                 830        
 Lys Ala Leu Ser Ala Ala Val Ala Asp Ser Leu Thr Asn Ser Pro Arg
         835                 840                 845            
 Asp Ser Pro Ala Val Ser Leu Ser Glu Pro Ala Thr Gln Gln Ala Ser
     850                 855                 860                
 Leu Asp Val Glu Lys Pro Val Gly Val Ala Ala Ser Leu Ser Asp Ile
 865                 870                 875                 880
 Pro Lys Ala Ala Glu Pro Gly Lys Leu Glu Gln Val Arg Pro Gln Glu
                 885                 890                 895    
 Leu Ser Arg Val Gln Glu Leu Ala Pro Ala Ser Gly Glu Lys Ala Arg
             900                 905                 910        
 Leu Ser Glu Ala Pro Gly Gly Lys Lys Ser Leu Ser Met Leu His Tyr
         915                 920                 925            
 Ile Arg Gly Ala Ala Pro Lys Asp Ile Pro Val Pro Leu Ser His Ser
     930                 935                 940                
 Thr Asn Gly Lys Ser Lys Pro Trp Glu Pro Phe Val Ala Glu Glu Phe
 945                 950                 955                 960
 Ala His Gln Phe His Glu Ser Val Leu Gln Ser Thr Gln Lys Ala Leu
                 965                 970                 975    
 Gln Lys His Lys Gly Ser Val Ala Val Leu Ser Ala Glu Gln Asn His
             980                 985                 990        
 Lys Val Asp Thr Ser Val His Tyr Asn Ile Pro Glu Leu Gln Ser Ser
         995                1000                1005            
 Ser Arg Ala Pro Pro Pro Gln His Asn Gly Gln Gln Glu Pro Pro Thr
    1010                1015                1020                
 Ala Arg Lys Gly Pro Pro Thr Gln Glu Leu Asp Arg Asp Ser Glu Glu
1025                1030                1035                1040
 Glu Glu Glu Glu Asp Asp Glu Asp Gly Glu Asp Glu Glu Glu Val Pro
                1045                1050                1055    
 Lys Arg Lys Trp Gln Gly Ile Glu Ala Val Phe Glu Ala Tyr Gln Glu
            1060                1065                1070        
 His Ile Glu Glu Gln Asn Leu Glu Arg Gln Val Leu Gln Thr Gln Cys
        1075                1080                1085            
 Arg Arg Leu Glu Ala Arg His Tyr Ser Leu Ser Leu Thr Ala Glu Gln
    1090                1095                1100                
 Leu Ser His Ser Val Ala Glu Leu Arg Ser Gln Lys Gln Lys Met Val
1105                1110                1115                1120
 Ser Glu Arg Glu Arg Leu Gln Ala Glu Leu Asp His Leu Arg Lys Cys
                1125                1130                1135    
 Leu Ala Leu Pro Ala Met His Trp Pro Arg Gly Tyr Leu Lys Gly Tyr
            1140                1145                1150        
 Pro Arg
        



      <210> 1074
      <211> 64
      <212> PRT
      <213> Homo sapiens


      <400> 1074
 Met Glu Leu Ser Ser Asn Gly Ile Glu Trp Tyr Gln Pro Ile Lys Arg
   1               5                  10                  15    
 Lys Lys Thr Glu Leu Ser Asn Gly Ile Glu Glu Asn His Arg Met Asp
              20                  25                  30        
 Ser Asn Gly Ile Ile Ile Glu Arg Asn Arg Met Glu Ser Ser Ser Asp
          35                  40                  45            
 Gly Asn Glu Trp Asn His His Arg Met Glu Met Lys Gly Val Ile Ile
      50                  55                  60                





      <210> 1075
      <211> 73
      <212> PRT
      <213> Homo sapiens


      <400> 1075
 Met Glu Asn Gln Leu Ser Ser Glu Ser His Phe Cys Ser Pro Ser Lys
   1               5                  10                  15    
 Trp Trp Leu Phe Phe Ser Asn Leu Asn Leu Thr Tyr Leu Ile Phe Pro
              20                  25                  30        
 Arg Leu Gly Ser Arg Gly Pro Arg Thr Thr Ala Arg Leu Phe Thr Gln
          35                  40                  45            
 Phe Lys Glu Asn Pro Ala Arg Cys Arg Leu Met Pro Phe Tyr Tyr Ile
      50                  55                  60                
 Pro Phe Ile Gln Phe Phe Val Phe Tyr
  65                  70            



      <210> 1076
      <211> 75
      <212> PRT
      <213> Homo sapiens


      <400> 1076
 Met Thr Gly Ile Asp Ser Ser Pro Glu Glu Ile Leu Arg Gln Val Gly
   1               5                  10                  15    
 Cys Lys Gln Gln Gln Gly Lys Gly Val Glu His Val Glu Gly Ser Ser
              20                  25                  30        
 Ala Glu Ala Gly Glu Ala Ala Arg Gly Gly Gly Ala Lys Gly Gly Gly
          35                  40                  45            
 Gly Ala Ala Gly Lys Gly Thr Ser Lys Val Gly Thr Leu Arg Ala Pro
      50                  55                  60                
 Glu Ser Leu Ser Met Phe Ile Ser Tyr Thr Pro
  65                  70                  75



      <210> 1077
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 1077
 Met Pro Asn Leu Leu Asn Thr Met Met Glu Leu Arg Lys Cys Cys Asn
   1               5                  10                  15    
 His Pro Tyr Leu Ile Asn Gly Ala Glu Glu Lys Ile Leu Thr Glu Phe
              20                  25                  30        
 Arg Glu Ala Cys His Ile Ile Pro His Asp Phe His Leu Gln Ala Met
          35                  40                  45            
 Val Arg Ser Ala Gly Lys Leu Val Leu Ile Asp Lys Leu Leu Pro Lys
      50                  55                  60                
 Leu Lys Ala Gly Gly His Lys Val Leu Ile Phe Ser Gln Met Val Arg
  65                  70                  75                  80
 Cys Leu Asp Ile Leu Glu Asp Tyr Leu Ile Gln Arg Arg Tyr Leu Tyr
                  85                  90                  95    
 Glu Arg Ile Asp Gly Arg Val Arg Gly Asn Leu Arg Gln Ala Ala Ile
             100                 105                 110        
 Asp Arg Phe Ser Lys Pro Asp Ser Asp Arg Phe Val Phe Leu Leu Cys
         115                 120                 125            
 Thr Arg Ala Gly Gly Leu Gly Ile Asn Leu Thr Ala Ala Gly Glu Asp
     130                 135                 140                
 Ala
 145



      <210> 1078
      <211> 409
      <212> PRT
      <213> Homo sapiens


      <400> 1078
 Met Ala Glu Phe Gly Pro Thr Ser His Ala Pro Gly Arg His Gly Arg
   1               5                  10                  15    
 Gly Ile Ser Arg Val Asp Asp Phe Val Ser Val Gln Cys Tyr Gln Phe
              20                  25                  30        
 Gly Trp Ser Pro Asn Phe Pro Thr Cys Lys Gly Gln Val Arg Ser Cys
          35                  40                  45            
 Gly Pro Pro Pro Gln Leu Ser Asn Gly Glu Val Lys Glu Ile Arg Lys
      50                  55                  60                
 Glu Glu Tyr Gly His Asn Glu Val Val Glu Tyr Asp Cys Asn Pro Asn
  65                  70                  75                  80
 Phe Ile Ile Asn Gly Pro Lys Lys Ile Gln Cys Val Asp Gly Glu Trp
                  85                  90                  95    
 Thr Thr Leu Pro Thr Cys Val Glu Gln Val Lys Thr Cys Gly Tyr Ile
             100                 105                 110        
 Pro Glu Leu Glu Tyr Gly Tyr Val Gln Pro Ser Val Pro Pro Tyr Gln
         115                 120                 125            
 His Gly Val Ser Val Glu Val Asn Cys Arg Asn Glu Tyr Ala Met Ile
     130                 135                 140                
 Gly Asn Asn Met Ile Thr Cys Ile Asn Gly Ile Trp Thr Glu Leu Pro
 145                 150                 155                 160
 Met Cys Val Ala Thr His Gln Leu Lys Arg Cys Lys Ile Ala Gly Val
                 165                 170                 175    
 Asn Ile Lys Thr Leu Leu Lys Leu Ser Gly Lys Glu Phe Asn His Asn
             180                 185                 190        
 Ser Arg Ile Arg Tyr Arg Cys Ser Asp Ile Phe Arg Tyr Arg His Ser
         195                 200                 205            
 Val Cys Ile Asn Gly Lys Trp Asn Pro Glu Val Asp Cys Thr Glu Lys
     210                 215                 220                
 Arg Glu Gln Phe Cys Pro Pro Pro Pro Gln Ile Pro Asn Ala Gln Asn
 225                 230                 235                 240
 Met Thr Thr Thr Val Asn Tyr Gln Asp Gly Glu Lys Val Ala Val Leu
                 245                 250                 255    
 Cys Lys Glu Asn Tyr Leu Leu Pro Glu Ala Lys Glu Ile Val Cys Lys
             260                 265                 270        
 Asp Gly Arg Trp Gln Ser Leu Pro Arg Cys Val Glu Ser Thr Ala Tyr
         275                 280                 285            
 Cys Gly Pro Pro Pro Ser Ile Asn Asn Gly Asp Thr Thr Ser Phe Pro
     290                 295                 300                
 Leu Ser Val Tyr Pro Pro Gly Ser Thr Val Thr Tyr Arg Cys Gln Ser
 305                 310                 315                 320
 Phe Tyr Lys Leu Gln Gly Ser Val Thr Val Thr Cys Arg Asn Lys Gln
                 325                 330                 335    
 Trp Ser Glu Pro Pro Arg Cys Leu Asp Pro Cys Val Val Ser Glu Glu
             340                 345                 350        
 Asn Met Asn Lys Asn Asn Ile Gln Leu Lys Trp Arg Asn Asp Gly Lys
         355                 360                 365            
 Leu Tyr Ala Lys Thr Gly Asp Ala Val Glu Phe Gln Cys Lys Phe Pro
     370                 375                 380                
 His Lys Ala Met Ile Ser Ser Pro Pro Phe Arg Ala Ile Cys Gln Glu
 385                 390                 395                 400
 Gly Lys Phe Glu Tyr Pro Ile Cys Glu
                 405                



      <210> 1079
      <211> 83
      <212> PRT
      <213> Homo sapiens


      <400> 1079
 Met Thr Thr Ser Pro Ile Thr Ser Pro Gly Leu Gln Arg Gln Pro Pro
   1               5                  10                  15    
 Gln Ser Phe Leu Val Met Tyr Gln Arg Ile Pro Asp Gly Arg Cys Val
              20                  25                  30        
 Thr Trp Cys Ser Ile Leu Pro Val Lys His Asn Ser Leu Ser Met Glu
          35                  40                  45            
 Ala Phe Glu Lys Lys Thr Pro Phe Lys Val Lys Leu Tyr Tyr Val Thr
      50                  55                  60                
 Gly Thr Phe Val Lys Asn Leu Leu Thr Ser Lys Lys Pro Arg Thr Glu
  65                  70                  75                  80
 Ile Gln Gln
            



      <210> 1080
      <211> 294
      <212> PRT
      <213> Homo sapiens


      <400> 1080
 Met Lys Ser Leu Ala Glu Gln Met Arg Asn His Asp Arg Glu Gln Met
   1               5                  10                  15    
 Ser Arg Met Ala His Asn Leu Pro Glu Gln Tyr Gln Glu Cys Ala Pro
              20                  25                  30        
 Val Glu Gln Val Ala Gln Val Phe Asn Lys Leu Phe Asn Glu Leu Arg
          35                  40                  45            
 Ala Ala Phe Pro Ala Ser Met Ala Asn Phe Arg Thr Gln Glu Asp Leu
      50                  55                  60                
 Asn Glu Phe Arg Arg Gln Trp Leu Leu Ala Phe Gln Glu Asn Gly Ile
  65                  70                  75                  80
 His Thr Met Ala Gln Val Asp Ala Gly Met Arg Ile Ala Arg Arg Gln
                  85                  90                  95    
 Glu Arg Pro Phe Leu Pro Ser Pro Gly Gln Phe Val Ala Trp Cys Lys
             100                 105                 110        
 Gln Ser Gly Gly Ala Leu Gly Val Asn Val Asp Gln Val Ile Ala Glu
         115                 120                 125            
 Tyr Trp Glu Trp Arg Asn Arg Ser Phe Glu Phe Ile Ser Ser Glu Gln
     130                 135                 140                
 Phe Pro Trp Ser Gln Pro Val Met Tyr His Ile Cys Val Glu Leu Arg
 145                 150                 155                 160
 His Arg Ser Thr Glu Arg Gln Leu Thr His Gly Glu Leu Ala Arg Glu
                 165                 170                 175    
 Ala Gly Asp Leu Leu Asp Met Trp Glu Arg Arg Val Thr Glu Gly Lys
             180                 185                 190        
 Pro Val Pro Pro Val Arg Arg Ala Ile Ala Ala Pro Ala Ala Glu Gln
         195                 200                 205            
 Gly Pro Thr Pro Ile Gln Leu Leu Leu Ala Lys Tyr Asn Arg Asn Lys
     210                 215                 220                
 Ser Asn Gly Met Thr Ile Ala Glu Leu Glu Glu Glu Arg Asp Ala Thr
 225                 230                 235                 240
 Pro Gly Ala Val Asn Glu Asp Ala Ala Met Ala Leu Ala Ala Met Lys
                 245                 250                 255    
 Leu Ala Leu Ala Ser Leu Glu Ala Glu Pro Val Ala Trp Leu Leu Ser
             260                 265                 270        
 Gly Gly Gly Ala Lys Asn Asn Val Ser Phe Asp Ser Gly Asn Ala Tyr
         275                 280                 285            
 Ala Ala Gln Leu Arg Glu
     290                



      <210> 1081
      <211> 282
      <212> PRT
      <213> Homo sapiens


      <400> 1081
 Met Gly Pro Leu Pro Arg Thr Val Glu Leu Phe Tyr Asp Val Leu Ser
   1               5                  10                  15    
 Pro Tyr Ser Trp Leu Gly Phe Glu Ile Leu Cys Arg Tyr Gln Asn Ile
              20                  25                  30        
 Trp Asn Ile Asn Leu Gln Leu Arg Pro Ser Leu Ile Thr Gly Ile Met
          35                  40                  45            
 Lys Asp Ser Gly Asn Lys Pro Pro Gly Leu Leu Pro Arg Lys Gly Leu
      50                  55                  60                
 Tyr Met Ala Asn Asp Leu Lys Leu Leu Arg His His Leu Gln Ile Pro
  65                  70                  75                  80
 Ile His Phe Pro Lys Asp Phe Leu Ser Val Met Leu Glu Lys Gly Ser
                  85                  90                  95    
 Leu Ser Ala Met Arg Phe Leu Thr Ala Val Asn Leu Glu His Pro Glu
             100                 105                 110        
 Met Leu Glu Lys Ala Ser Arg Glu Leu Trp Met Arg Val Trp Ser Arg
         115                 120                 125            
 Val Ser Val Gly Leu Trp Glu Ser Ser Gly Arg Thr Leu Asp Asp Phe
     130                 135                 140                
 Leu Thr Phe Pro Arg His Val Phe Arg Val Met Ile Leu Pro Pro Pro
 145                 150                 155                 160
 Gly Asp Ser Thr Val Leu Pro Val Thr Pro Leu Ser Pro His Arg Leu
                 165                 170                 175    
 Pro Ala Val Phe Ser Ser Ser Gln Asn Glu Asp Ile Thr Glu Pro Gln
             180                 185                 190        
 Ser Ile Leu Ala Ala Ala Glu Lys Ala Gly Met Ser Ala Glu Gln Ala
         195                 200                 205            
 Gln Gly Leu Leu Glu Lys Ile Ala Thr Pro Lys Val Lys Asn Gln Leu
     210                 215                 220                
 Lys Glu Thr Thr Glu Ala Ala Cys Arg Tyr Gly Ala Phe Gly Leu Pro
 225                 230                 235                 240
 Ile Thr Val Ala His Val Asp Gly Gln Thr His Met Leu Phe Gly Ser
                 245                 250                 255    
 Asp Arg Met Glu Leu Leu Ala His Leu Leu Gly Glu Lys Trp Met Gly
             260                 265                 270        
 Pro Ile Pro Pro Ala Val Asn Ala Arg Leu
         275                 280        



      <210> 1082
      <211> 214
      <212> PRT
      <213> Homo sapiens


      <400> 1082
 Met Gly Pro Leu Pro Arg Thr Val Glu Leu Phe Tyr Asp Val Leu Ser
   1               5                  10                  15    
 Pro Tyr Ser Trp Leu Gly Phe Glu Ile Leu Cys Arg Tyr Gln Asn Ile
              20                  25                  30        
 Trp Asn Ile Asn Leu Gln Leu Arg Pro Ser Leu Ile Thr Gly Ile Met
          35                  40                  45            
 Lys Asp Ser Gly Asn Lys Pro Pro Gly Leu Leu Pro Arg Lys Gly Leu
      50                  55                  60                
 Tyr Met Ala Asn Asp Leu Lys Leu Leu Arg His His Leu Gln Ile Pro
  65                  70                  75                  80
 Ile His Phe Pro Lys Asp Phe Leu Ser Val Met Leu Glu Lys Gly Ser
                  85                  90                  95    
 Leu Ser Ala Met Arg Phe Leu Thr Ala Val Asn Leu Glu His Pro Glu
             100                 105                 110        
 Met Leu Glu Lys Ala Ser Arg Glu Leu Trp Met Arg Val Trp Ser Arg
         115                 120                 125            
 Ala Ala Glu Lys Ala Gly Met Ser Ala Glu Gln Ala Gln Gly Leu Leu
     130                 135                 140                
 Glu Lys Ile Ala Thr Pro Lys Val Lys Asn Gln Leu Lys Glu Thr Thr
 145                 150                 155                 160
 Glu Ala Ala Cys Arg Tyr Gly Ala Phe Gly Leu Pro Ile Thr Val Ala
                 165                 170                 175    
 His Val Asp Gly Gln Thr His Met Leu Phe Gly Ser Asp Arg Met Glu
             180                 185                 190        
 Leu Leu Ala His Leu Leu Gly Glu Lys Trp Met Gly Pro Ile Pro Pro
         195                 200                 205            
 Ala Val Asn Ala Arg Leu
     210                



      <210> 1083
      <211> 94
      <212> PRT
      <213> Homo sapiens


      <400> 1083
 Met Arg Leu Asn Lys Glu Asp Met His Leu Phe Gly His Tyr Pro Ala
   1               5                  10                  15    
 His Asp Asp Phe Tyr Leu Val Val Cys Ser Ala Cys Asn Gln Val Val
              20                  25                  30        
 Lys Pro Gln Val Phe Gln Ser His Cys Gly Lys Trp Thr Pro Ala Pro
          35                  40                  45            
 Ser Ala Thr Ser Ala Ala Ala Ala Leu Gly Thr Val Ala Phe Pro Trp
      50                  55                  60                
 Ala Pro Arg Gln Gly Leu Ala Met Ser Cys Leu Ser Leu Arg Leu Trp
  65                  70                  75                  80
 Val Lys Ser Ser Trp Ala Ala Ala Ser Ala Arg Arg Leu Phe
                  85                  90                



      <210> 1084
      <211> 987
      <212> PRT
      <213> Homo sapiens


      <400> 1084
 Met Gly Leu Ala Gln Glu Ala Gln Arg Gln Glu Val Leu Gln Gln Val
   1               5                  10                  15    
 Leu Arg Leu Gln Val Arg Glu Glu Gly Arg Ser Leu Gln Leu Leu Ser
              20                  25                  30        
 Gln Glu Thr His Gly Thr Arg His Ile Pro Gly Ala His Lys His Thr
          35                  40                  45            
 Val Phe His Asp Thr Leu Ala Cys Arg Cys Ser Gln Lys Thr Ala Val
      50                  55                  60                
 Pro His Gln His Pro Asp Thr Glu Thr Cys Arg Ser Leu Asp Thr Trp
  65                  70                  75                  80
 Ile Leu Lys Ser Arg His Ile Val Pro Ser Pro Val Leu Ser Val Pro
                  85                  90                  95    
 Arg His Leu Gln Thr Thr Gln Pro Thr Pro Asp Pro Ser Ala Pro Cys
             100                 105                 110        
 Leu Gln Lys Pro Lys Leu Trp Gly Arg Glu Gly Pro Gly Thr Gly Ser
         115                 120                 125            
 Glu Pro Leu Pro Pro Glu Leu Gly Lys Gly Asp Pro Met Glu Cys Ile
     130                 135                 140                
 Thr Phe Gly Ile Ile Phe Ala Ala Val Gly Leu Arg Thr Leu Trp Ser
 145                 150                 155                 160
 Cys Val His Cys Arg Ala Ala Cys Trp Glu Gly Gly Leu Glu Val Glu
                 165                 170                 175    
 Met Thr Asp Pro Phe Cys Val Gly Gly Arg Arg Leu Pro Gly Ser Ser
             180                 185                 190        
 Lys Ser Gly Pro Gly Lys Asp Gly Ser Arg Lys Glu Val Arg Leu Pro
         195                 200                 205            
 Met Leu His Asp Pro Pro Lys Met Gly Met Pro Val Val Arg Gly Gly
     210                 215                 220                
 Gln Thr Val Pro Gly Gln Ala Pro Leu Cys Phe Asp Pro Gly Ser Pro
 225                 230                 235                 240
 Ala Ser Asp Lys Thr Glu Gly Lys Lys Lys Gly Arg Pro Lys Ala Glu
                 245                 250                 255    
 Asn Gln Ala Leu Arg Asp Ile Pro Leu Ser Leu Met Asn Asp Trp Lys
             260                 265                 270        
 Asp Glu Phe Lys Ala His Ser Arg Val Lys Cys Pro Asn Ser Gly Cys
         275                 280                 285            
 Trp Leu Glu Phe Pro Ser Ile Tyr Gly Leu Lys Tyr His Tyr Gln Arg
     290                 295                 300                
 Cys Gln Gly Gly Ala Ile Ser Asp Arg Leu Ala Phe Pro Cys Pro Phe
 305                 310                 315                 320
 Cys Glu Ala Ala Phe Thr Ser Lys Thr Gln Leu Glu Lys His Arg Ile
                 325                 330                 335    
 Trp Asn His Met Asp Arg Pro Leu Pro Ala Ser Lys Pro Gly Pro Ile
             340                 345                 350        
 Ser Arg Pro Val Thr Ile Ser Arg Pro Val Gly Val Ser Lys Pro Ile
         355                 360                 365            
 Gly Val Ser Lys Pro Val Thr Ile Gly Lys Pro Val Gly Val Ser Lys
     370                 375                 380                
 Pro Ile Gly Ile Ser Lys Pro Val Ser Val Gly Arg Pro Met Pro Val
 385                 390                 395                 400
 Thr Lys Ala Ile Pro Val Thr Arg Pro Val Pro Val Thr Lys Pro Val
                 405                 410                 415    
 Thr Val Ser Arg Pro Met Pro Val Thr Lys Ala Met Pro Val Thr Lys
             420                 425                 430        
 Pro Ile Thr Val Thr Lys Ser Val Pro Val Thr Lys Pro Val Pro Val
         435                 440                 445            
 Thr Lys Pro Ile Thr Val Thr Lys Leu Val Thr Val Thr Lys Pro Val
     450                 455                 460                
 Pro Val Thr Lys Pro Val Thr Val Ser Arg Pro Ile Val Val Ser Lys
 465                 470                 475                 480
 Pro Val Thr Val Ser Arg Pro Ile Ala Ile Ser Arg His Thr Pro Pro
                 485                 490                 495    
 Cys Lys Met Val Leu Leu Thr Arg Ser Glu Asn Lys Ala Pro Arg Ala
             500                 505                 510        
 Thr Gly Arg Asn Ser Gly Lys Lys Arg Ala Ala Asp Ser Leu Asp Thr
         515                 520                 525            
 Cys Pro Thr Pro Pro Lys Gln Ala Arg Pro Glu Asn Gly Glu Tyr Gly
     530                 535                 540                
 Pro Ser Ser Met Gly Gln Ser Ser Ala Phe Gln Leu Ser Ala Asp Thr
 545                 550                 555                 560
 Ser Ser Gly Ser Leu Ser Pro Gly Ser Arg Pro Ser Gly Gly Met Glu
                 565                 570                 575    
 Ala Leu Lys Ala Ala Gly Pro Ala Ser Pro Pro Glu Glu Asp Pro Glu
             580                 585                 590        
 Arg Thr Lys His Ser Leu Val Lys Ala Glu Asp Lys Ala Arg Val His
         595                 600                 605            
 Arg Ser Lys Lys Gln Glu Gly Pro Gly Pro Glu Asp Ala Arg Lys Lys
     610                 615                 620                
 Val Pro Ala Ala Pro Ile Thr Val Ser Lys Glu Ala Pro Ala Pro Val
 625                 630                 635                 640
 Ala His Pro Ala Pro Gly Gly Pro Glu Glu Gln Trp Gln Arg Ala Ile
                 645                 650                 655    
 His Glu Arg Gly Glu Ala Val Cys Pro Thr Cys Asn Val Val Thr Arg
             660                 665                 670        
 Lys Thr Leu Val Gly Leu Lys Lys His Met Glu Val Cys Gln Lys Leu
         675                 680                 685            
 Gln Asp Ala Leu Lys Cys Gln His Cys Arg Lys Gln Phe Lys Ser Lys
     690                 695                 700                
 Ala Gly Leu Asn Tyr His Thr Met Ala Glu His Ser Ala Lys Pro Ser
 705                 710                 715                 720
 Asp Ala Glu Ala Ser Glu Gly Gly Glu Gln Glu Glu Arg Glu Arg Leu
                 725                 730                 735    
 Arg Lys Val Leu Lys Gln Met Gly Arg Leu Arg Cys Pro Gln Glu Gly
             740                 745                 750        
 Cys Gly Ala Ala Phe Ser Ser Leu Met Gly Tyr Gln Tyr His Gln Arg
         755                 760                 765            
 Arg Cys Gly Lys Pro Pro Cys Glu Val Asp Ser Pro Ser Phe Pro Cys
     770                 775                 780                
 Thr His Cys Gly Lys Thr Tyr Arg Ser Lys Ala Gly His Asp Tyr His
 785                 790                 795                 800
 Val Arg Ser Glu His Thr Ala Pro Pro Pro Glu Glu Pro Thr Asp Lys
                 805                 810                 815    
 Ser Pro Glu Ala Glu Asp Pro Leu Gly Val Glu Arg Thr Pro Ser Gly
             820                 825                 830        
 Arg Val Arg Arg Thr Ser Ala Gln Val Ala Val Phe His Leu Gln Glu
         835                 840                 845            
 Ile Ala Glu Asp Glu Leu Ala Arg Asp Trp Thr Lys Arg Arg Met Lys
     850                 855                 860                
 Asp Asp Leu Val Pro Glu Thr Ala Arg Leu Asn Tyr Thr Arg Pro Gly
 865                 870                 875                 880
 Leu Pro Thr Leu Asn Pro Gln Leu Leu Glu Ala Trp Lys Asn Glu Val
                 885                 890                 895    
 Lys Glu Lys Gly His Val Asn Cys Pro Asn Asp Cys Cys Glu Ala Ile
             900                 905                 910        
 Tyr Ser Ser Val Ser Gly Leu Lys Ala His Leu Ala Ser Cys Ser Lys
         915                 920                 925            
 Gly Ala His Leu Ala Gly Lys Tyr Arg Cys Leu Leu Cys Pro Lys Glu
     930                 935                 940                
 Phe Ser Ser Glu Ser Gly Val Lys Tyr His Ile Leu Lys Thr His Ala
 945                 950                 955                 960
 Glu Asn Trp Phe Arg Thr Ser Ala Asp Pro Pro Pro Lys His Arg Ser
                 965                 970                 975    
 Gln Asp Ser Leu Val Pro Lys Lys Lys Lys Lys
             980                 985        



      <210> 1085
      <211> 106
      <212> PRT
      <213> Homo sapiens


      <400> 1085
 Met Lys Val Tyr Val Leu Pro Gly Lys Tyr Lys Tyr Asn Arg Gly Ser
   1               5                  10                  15    
 Ile Ser Ile Thr Asn Glu Ser Ile Ser Thr Ala Ser Val Thr Arg Gly
              20                  25                  30        
 Pro Cys Ser Glu Ser Ser Gln Asp Gly Gly Gly Pro Leu Pro Lys Trp
          35                  40                  45            
 Arg Gln Ala Thr Ser Lys Met Val Ala Ser Leu Val Phe Ser Asp Leu
      50                  55                  60                
 Gly Phe Leu Ala Ser Arg Ile Pro Arg Asn Gly Ile Leu Gly Arg Ala
  65                  70                  75                  80
 Val Ser Val Ile Ala Leu Leu Glu Val Val Gly His Arg Arg Glu Pro
                  85                  90                  95    
 Trp Asn Pro Val Thr Ser Val Gln Leu Asp
             100                 105    



      <210> 1086
      <211> 690
      <212> PRT
      <213> Homo sapiens


      <400> 1086
 Met Met Val Glu Ser Ala Ser Glu Thr Ile Arg Ser Ala Pro Ser Gly
   1               5                  10                  15    
 Gln Asn Gly Val Gly Ser Leu Ser Gly Gln Ala Asp Gly Ser Ser Gly
              20                  25                  30        
 Gly Ala Thr Gly Thr Thr Ala Ser Gly Thr Gly Arg Glu Val Thr Thr
          35                  40                  45            
 Gly Ala Asp Ser Asn Gly Glu Met Ser Pro Ala Glu Leu Leu His Phe
      50                  55                  60                
 Gln Gln Gln Gln Ala Leu Gln Val Ala Arg Gln Phe Leu Leu Gln Gln
  65                  70                  75                  80
 Ala Ser Gly Leu Ser Ser Pro Gly Asn Asn Asp Ser Lys Gln Ser Ala
                  85                  90                  95    
 Ser Ala Val Gln Gly Thr Gly Leu Thr Gly Arg Ile Leu Gln Val Pro
             100                 105                 110        
 Val Ser Val Ala Met Met Ser Pro Gln Met Leu Thr Pro Gln Gln Met
         115                 120                 125            
 Gln Gln Ile Leu Ser Pro Pro Gln Leu Gln Ala Leu Leu Gln Gln Gln
     130                 135                 140                
 Gln Ala Leu Met Leu Gln Gln Leu Gln Glu Tyr Tyr Lys Lys Gln Gln
 145                 150                 155                 160
 Glu Gln Leu His Leu Gln Leu Leu Thr Gln Gln Gln Ala Gly Lys Pro
                 165                 170                 175    
 Gln Pro Lys Glu Ala Leu Gly Asn Lys Gln Leu Ala Phe Gln Gln Gln
             180                 185                 190        
 Leu Leu Gln Met Gln Gln Leu Gln Gln Gln His Leu Leu Asn Leu Gln
         195                 200                 205            
 Arg Gln Gly Leu Val Ser Leu Gln Pro Asn Gln Ala Ser Gly Pro Leu
     210                 215                 220                
 Gln Thr Leu Pro Gln Ala Ala Val Cys Pro Thr Asp Leu Pro Gln Leu
 225                 230                 235                 240
 Trp Lys Gly Glu Gly Ala Pro Gly Gln Pro Ala Glu Asp Ser Val Lys
                 245                 250                 255    
 Gln Glu Gly Leu Asp Leu Thr Gly Thr Ala Ala Thr Ala Thr Ser Phe
             260                 265                 270        
 Ala Ala Pro Pro Lys Val Ser Pro Pro Leu Ser His His Thr Leu Pro
         275                 280                 285            
 Asn Gly Gln Pro Thr Val Leu Thr Ser Arg Arg Asp Ser Ser Ser His
     290                 295                 300                
 Glu Glu Thr Pro Gly Ser His Pro Leu Tyr Gly His Gly Glu Cys Lys
 305                 310                 315                 320
 Trp Pro Gly Cys Glu Thr Leu Cys Glu Asp Leu Gly Gln Phe Ile Lys
                 325                 330                 335    
 His Leu Asn Thr Glu His Ala Leu Asp Asp Arg Ser Thr Ala Gln Cys
             340                 345                 350        
 Arg Val Gln Met Gln Val Val Gln Gln Leu Glu Ile Gln Leu Ala Lys
         355                 360                 365            
 Glu Ser Glu Arg Leu Gln Ala Met Met Ala His Leu His Met Arg Pro
     370                 375                 380                
 Ser Glu Pro Lys Pro Phe Ser Gln Pro Leu Asn Pro Val Pro Gly Ser
 385                 390                 395                 400
 Ser Ser Phe Ser Lys Val Thr Val Ser Ala Ala Asp Ser Phe Pro Asp
                 405                 410                 415    
 Gly Leu Val His Pro Pro Thr Ser Ala Ala Ala Pro Val Thr Pro Leu
             420                 425                 430        
 Arg Pro Pro Gly Leu Gly Ser Ala Ser Leu His Gly Gly Gly Pro Ala
         435                 440                 445            
 Arg Arg Arg Ser Ser Asp Lys Phe Cys Ser Pro Ile Ser Ser Glu Leu
     450                 455                 460                
 Ala Gln Asn His Glu Phe Tyr Lys Asn Ala Asp Val Arg Pro Pro Phe
 465                 470                 475                 480
 Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu Thr Pro Asp Arg
                 485                 490                 495    
 Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr Arg Met Phe Ala
             500                 505                 510        
 Tyr Phe Arg Arg Asn Thr Ala Thr Trp Lys Asn Ala Val Arg His Asn
         515                 520                 525            
 Leu Ser Leu His Lys Cys Phe Ala Arg Val Glu Asn Val Lys Gly Ala
     530                 535                 540                
 Val Trp Thr Val Asp Glu Arg Glu Tyr Gln Lys Arg Arg Pro Pro Lys
 545                 550                 555                 560
 Met Thr Gly Ser Pro Thr Leu Val Lys Asn Met Ile Ser Gly Leu Ser
                 565                 570                 575    
 Tyr Gly Ala Leu Asn Ala Ser Tyr Gln Ala Ala Leu Ala Glu Ser Ser
             580                 585                 590        
 Phe Pro Leu Leu Asn Ser Pro Gly Met Leu Asn Pro Gly Ser Ala Ser
         595                 600                 605            
 Ser Leu Leu Pro Leu Ser His Asp Asp Val Gly Ala Pro Val Glu Pro
     610                 615                 620                
 Leu Pro Ser Asn Gly Ser Ser Ser Pro Pro Arg Leu Ser Pro Pro Gln
 625                 630                 635                 640
 Tyr Ser His Gln Val Gln Val Lys Glu Glu Pro Ala Glu Ala Glu Glu
                 645                 650                 655    
 Asp Arg Gln Pro Gly Pro Pro Leu Gly Ala Pro Asn Pro Ser Ala Ser
             660                 665                 670        
 Gly Pro Pro Glu Asp Arg Asp Leu Glu Glu Glu Leu Pro Gly Glu Glu
         675                 680                 685            
 Leu Ser
     690



      <210> 1087
      <211> 379
      <212> PRT
      <213> Homo sapiens


      <400> 1087
 Met Val Asp Lys Ala Arg Val Ser Gln Gly Ser Cys Leu Tyr Glu Lys
   1               5                  10                  15    
 Glu Glu Ser Glu Tyr Ile Cys Leu Val Ile Phe Ala Lys Asn Glu Glu
              20                  25                  30        
 Met Thr Thr Glu Glu Thr Gln Phe Arg Glu Arg Val Arg Asp Ala Ala
          35                  40                  45            
 Glu Leu Pro Cys Pro Gly Leu Val Arg Gly Arg Glu Lys Val Phe Glu
      50                  55                  60                
 Glu Glu Lys Ala His Pro Ser Ser Glu Lys Leu Arg Leu Arg Gly Thr
  65                  70                  75                  80
 His Ser Phe Ser Tyr Lys Met Gly Glu Asn Ser Pro Lys Gly His Ile
                  85                  90                  95    
 Leu Met Gln Glu Ser Gln Arg Asn Val Lys Leu Cys Ala Ser Gln Ser
             100                 105                 110        
 Pro Val Thr Met Glu Gly Ala Cys Gly Lys Leu Met Lys Ile Thr Gly
         115                 120                 125            
 Pro Val Thr Val Lys Thr Ser Gly Thr Arg Phe Gly Ala Trp Met Thr
     130                 135                 140                
 Asp Pro Leu Ala Ser Glu Lys Asn Asn Arg Val Trp Tyr Met Asp Ser
 145                 150                 155                 160
 Tyr Thr Asn Asn Lys Ile Val Arg Glu Tyr Lys Ser Ile Ala Asp Phe
                 165                 170                 175    
 Val Ser Gly Ala Glu Ser Arg Thr Tyr Asn Leu Pro Phe Lys Trp Ala
             180                 185                 190        
 Gly Thr Asn His Val Val Tyr Asn Gly Ser Leu Tyr Phe Asn Lys Tyr
         195                 200                 205            
 Gln Ser Asn Ile Ile Ile Lys Tyr Ser Phe Asp Met Gly Arg Val Leu
     210                 215                 220                
 Ala Gln Arg Ser Leu Glu Tyr Ala Gly Phe His Asn Val Tyr Pro Tyr
 225                 230                 235                 240
 Thr Trp Gly Gly Phe Ser Asp Ile Asp Leu Met Ala Asp Glu Ile Gly
                 245                 250                 255    
 Leu Trp Ala Val Tyr Ala Thr Asn Gln Asn Ala Gly Asn Ile Val Ile
             260                 265                 270        
 Ser Gln Leu Asn Gln Asp Thr Leu Glu Val Met Lys Ser Trp Ser Thr
         275                 280                 285            
 Gly Tyr Pro Lys Arg Ser Ala Gly Glu Ser Phe Met Ile Cys Gly Thr
     290                 295                 300                
 Leu Tyr Val Thr Asn Ser His Leu Thr Gly Ala Lys Val Tyr Tyr Ser
 305                 310                 315                 320
 Tyr Ser Thr Lys Thr Ser Thr Tyr Glu Tyr Thr Asp Ile Pro Phe His
                 325                 330                 335    
 Asn Gln Tyr Phe His Ile Ser Met Leu Asp Tyr Asn Ala Arg Asp Arg
             340                 345                 350        
 Ala Leu Tyr Ala Trp Asn Asn Gly His Gln Val Leu Phe Asn Val Thr
         355                 360                 365            
 Leu Phe His Ile Ile Lys Thr Glu Asp Asp Thr
     370                 375                



      <210> 1088
      <211> 293
      <212> PRT
      <213> Homo sapiens


      <400> 1088
 Leu Ala Leu Glu Ala Lys Asn Ser Ala Arg Gly Lys Pro Arg Thr Gly
   1               5                  10                  15    
 Ile Met Ala Ala Glu Thr Arg Asn Val Ala Gly Ala Glu Ala Pro Pro
              20                  25                  30        
 Pro Gln Lys Arg Tyr Tyr Arg Gln Arg Ala His Ser Asn Pro Met Ala
          35                  40                  45            
 Asp His Thr Leu Arg Tyr Pro Val Lys Pro Glu Glu Met Asp Trp Ser
      50                  55                  60                
 Glu Leu Tyr Pro Glu Phe Phe Ala Pro Leu Thr Gln Asn Gln Ser His
  65                  70                  75                  80
 Asp Asp Pro Lys Asp Lys Lys Glu Lys Arg Ala Gln Ala Gln Val Glu
                  85                  90                  95    
 Phe Ala Asp Ile Gly Cys Gly Tyr Gly Gly Leu Leu Val Glu Leu Ser
             100                 105                 110        
 Pro Leu Phe Pro Asp Thr Leu Ile Leu Gly Leu Glu Ile Arg Val Lys
         115                 120                 125            
 Val Ser Asp Tyr Val Gln Asp Arg Ile Arg Ala Leu Arg Ala Ala Pro
     130                 135                 140                
 Ala Gly Gly Phe Gln Asn Ile Ala Cys Leu Arg Ser Asn Ala Met Lys
 145                 150                 155                 160
 His Leu Pro Asn Phe Phe Tyr Lys Gly Gln Leu Thr Lys Met Phe Phe
                 165                 170                 175    
 Leu Phe Pro Asp Pro His Phe Lys Arg Thr Lys His Lys Trp Arg Ile
             180                 185                 190        
 Ile Ser Pro Thr Leu Leu Ala Glu Tyr Ala Tyr Val Leu Arg Val Gly
         195                 200                 205            
 Gly Leu Val Tyr Thr Ile Thr Asp Val Leu Glu Leu His Asp Trp Met
     210                 215                 220                
 Cys Thr His Phe Glu Glu His Pro Leu Phe Glu Arg Val Pro Leu Glu
 225                 230                 235                 240
 Asp Leu Ser Glu Asp Pro Val Val Gly His Leu Gly Thr Ser Thr Glu
                 245                 250                 255    
 Glu Gly Lys Lys Val Leu Arg Asn Gly Gly Lys Asn Phe Pro Ala Ile
             260                 265                 270        
 Phe Arg Arg Ile Gln Asp Pro Val Leu Gln Ala Val Thr Ser Gln Thr
         275                 280                 285            
 Ser Leu Pro Gly His
     290            



      <210> 1089
      <211> 97
      <212> PRT
      <213> Homo sapiens


      <400> 1089
 Met Arg Gly Gln Lys Ala Gly His Leu Lys Asn Asp Thr His Val His
   1               5                  10                  15    
 Ala Pro Val Tyr Thr Phe Thr Asp Ala His Thr Tyr Thr His Ala His
              20                  25                  30        
 Thr Leu Thr Cys Thr His Thr Tyr Ala Leu Asn Lys His Ile His Ile
          35                  40                  45            
 Leu Val Glu Thr His Ala His Thr Phe Thr Gln Thr Cys Thr Tyr Thr
      50                  55                  60                
 His Leu Tyr Val His Ile His Ile His Lys Pro Thr Asp Thr Cys Arg
  65                  70                  75                  80
 Tyr Ile Tyr Arg His Thr His Ser His Thr Pro Thr Val Leu Arg Pro
                  85                  90                  95    
 Leu
    



      <210> 1090
      <211> 466
      <212> PRT
      <213> Homo sapiens


      <400> 1090
 Met Lys Ile Pro His Gln Thr Gln Lys Lys Arg Ser Leu Glu Asp Pro
   1               5                  10                  15    
 Asn Ser Arg Pro Arg Arg Pro Ser Leu Arg Ser Ala Arg Arg Gln Ser
              20                  25                  30        
 Ala Pro Ser Leu Thr Glu Ser Pro Thr Ser Leu Pro Ser Cys Ile Ser
          35                  40                  45            
 Lys Met Ser Leu Ser Asn Lys Leu Thr Leu Asp Lys Leu Asp Val Lys
      50                  55                  60                
 Gly Lys Arg Val Val Met Arg Val Asp Phe Asn Val Pro Met Lys Asn
  65                  70                  75                  80
 Asn Gln Ile Thr Asn Asn Gln Arg Ile Lys Ala Ala Val Pro Ser Ile
                  85                  90                  95    
 Lys Phe Cys Leu Asp Asn Gly Ala Lys Ser Val Val Leu Met Ser His
             100                 105                 110        
 Leu Gly Arg Pro Asp Gly Val Pro Met Pro Asp Lys Tyr Ser Leu Glu
         115                 120                 125            
 Pro Val Ala Val Glu Leu Lys Ser Leu Leu Gly Lys Asp Val Leu Phe
     130                 135                 140                
 Leu Lys Asp Cys Val Gly Pro Glu Val Glu Lys Ala Cys Ala Asn Pro
 145                 150                 155                 160
 Ala Ala Gly Ser Val Ile Leu Leu Glu Asn Leu Arg Phe His Val Glu
                 165                 170                 175    
 Glu Glu Gly Lys Gly Lys Asp Ala Ser Gly Asn Lys Val Lys Ala Glu
             180                 185                 190        
 Pro Ala Lys Ile Glu Ala Phe Arg Ala Ser Leu Ser Lys Leu Gly Asp
         195                 200                 205            
 Val Tyr Val Asn Asp Ala Phe Gly Thr Ala His Arg Ala His Ser Ser
     210                 215                 220                
 Met Val Gly Val Asn Leu Pro Gln Lys Ala Gly Gly Phe Leu Met Lys
 225                 230                 235                 240
 Lys Glu Leu Asn Tyr Phe Ala Lys Ala Leu Glu Ser Pro Glu Arg Pro
                 245                 250                 255    
 Phe Leu Ala Ile Leu Gly Gly Ala Lys Val Ala Asp Lys Ile Gln Leu
             260                 265                 270        
 Ile Asn Asn Met Leu Asp Lys Val Asn Glu Met Ile Ile Gly Gly Gly
         275                 280                 285            
 Met Ala Phe Thr Phe Leu Lys Val Leu Asn Asn Met Glu Ile Gly Thr
     290                 295                 300                
 Ser Leu Phe Asp Glu Glu Gly Ala Lys Ile Val Lys Asp Leu Met Ser
 305                 310                 315                 320
 Lys Ala Glu Lys Asn Gly Val Lys Ile Thr Leu Pro Val Asp Phe Val
                 325                 330                 335    
 Thr Ala Asp Lys Phe Asp Glu Asn Ala Lys Thr Gly Gln Ala Thr Val
             340                 345                 350        
 Ala Ser Gly Ile Pro Ala Gly Trp Met Gly Leu Asp Cys Gly Pro Glu
         355                 360                 365            
 Ser Ser Lys Lys Tyr Ala Glu Ala Val Thr Arg Ala Lys Gln Ile Val
     370                 375                 380                
 Trp Asn Gly Pro Val Gly Val Phe Glu Trp Glu Ala Phe Ala Arg Gly
 385                 390                 395                 400
 Thr Lys Ala Leu Met Asp Glu Val Val Lys Ala Thr Ser Arg Gly Cys
                 405                 410                 415    
 Ile Thr Ile Ile Gly Gly Gly Asp Thr Ala Thr Cys Cys Ala Lys Trp
             420                 425                 430        
 Asn Thr Glu Asp Lys Val Ser His Val Ser Thr Gly Gly Gly Ala Ser
         435                 440                 445            
 Leu Glu Leu Leu Glu Gly Lys Val Leu Pro Gly Val Asp Ala Leu Ser
     450                 455                 460                
 Asn Ile
 465    



      <210> 1091
      <211> 260
      <212> PRT
      <213> Homo sapiens


      <400> 1091
 Met Gln Lys Tyr Glu Lys Leu Glu Lys Ile Gly Glu Gly Thr Tyr Gly
   1               5                  10                  15    
 Thr Val Phe Lys Ala Lys Asn Arg Glu Thr His Glu Ile Val Ala Leu
              20                  25                  30        
 Lys Arg Val Arg Leu Asp Asp Asp Asp Glu Gly Val Pro Ser Ser Ala
          35                  40                  45            
 Leu Arg Glu Ile Cys Leu Leu Lys Glu Leu Lys His Lys Asn Ile Val
      50                  55                  60                
 Arg Leu His Asp Val Leu His Ser Asp Lys Lys Leu Thr Leu Val Phe
  65                  70                  75                  80
 Glu Phe Cys Asp Gln Asp Leu Lys Lys Tyr Phe Asp Ser Cys Asn Gly
                  85                  90                  95    
 Asp Leu Asp Pro Glu Ile Val Lys Asn Gly Glu Leu Lys Leu Ala Asp
             100                 105                 110        
 Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Val Arg Cys Tyr Ser Ala
         115                 120                 125            
 Glu Val Val Thr Leu Trp Tyr Arg Pro Pro Asp Val Leu Phe Gly Ala
     130                 135                 140                
 Lys Leu Tyr Ser Thr Ser Ile Asp Met Trp Ser Ala Gly Cys Ile Phe
 145                 150                 155                 160
 Ala Glu Leu Ala Asn Ala Gly Arg Pro Leu Phe Pro Gly Asn Asp Val
                 165                 170                 175    
 Asp Asp Gln Leu Lys Arg Ile Phe Arg Leu Leu Gly Thr Pro Thr Glu
             180                 185                 190        
 Glu Gln Trp Pro Ser Met Thr Lys Leu Pro Asp Tyr Lys Pro Tyr Pro
         195                 200                 205            
 Met Tyr Pro Ala Thr Thr Ser Leu Val Asn Val Val Pro Lys Leu Asn
     210                 215                 220                
 Ala Thr Gly Arg Asp Leu Leu Gln Asn Leu Leu Lys Cys Asn Pro Val
 225                 230                 235                 240
 Gln Arg Ile Ser Ala Glu Glu Ala Leu Gln His Pro Tyr Phe Ser Asp
                 245                 250                 255    
 Phe Cys Pro Pro
             260



      <210> 1092
      <211> 342
      <212> PRT
      <213> Homo sapiens


      <400> 1092
 Met Asp Ala Ala Thr Leu Thr Tyr Asp Thr Leu Arg Phe Ala Glu Phe
   1               5                  10                  15    
 Glu Asp Phe Pro Glu Thr Ser Glu Pro Val Trp Ile Leu Gly Arg Lys
              20                  25                  30        
 Tyr Ser Ile Phe Thr Glu Lys Asp Glu Ile Leu Ser Asp Val Ala Ser
          35                  40                  45            
 Arg Leu Trp Phe Thr Tyr Arg Lys Asn Phe Pro Ala Ile Gly Gly Thr
      50                  55                  60                
 Gly Pro Thr Ser Asp Thr Gly Trp Gly Cys Met Leu Arg Cys Gly Gln
  65                  70                  75                  80
 Met Ile Phe Ala Gln Ala Leu Val Cys Arg His Leu Gly Arg Asp Trp
                  85                  90                  95    
 Arg Trp Thr Gln Arg Lys Arg Gln Pro Asp Ser Tyr Phe Ser Val Leu
             100                 105                 110        
 Asn Ala Phe Ile Asp Arg Lys Asp Ser Tyr Tyr Ser Ile His Gln Ile
         115                 120                 125            
 Gly Arg Leu Cys Arg Thr Ser Val Pro Cys Ala Gly Ala Thr Ala Phe
     130                 135                 140                
 Pro Ala Asp Ser Asp Arg His Cys Asn Gly Phe Pro Ala Gly Ala Glu
 145                 150                 155                 160
 Val Thr Asn Arg Pro Ser Pro Trp Arg Pro Leu Val Leu Leu Ile Pro
                 165                 170                 175    
 Leu Arg Leu Gly Leu Thr Asp Ile Asn Glu Ala Tyr Val Glu Thr Leu
             180                 185                 190        
 Lys His Cys Phe Met Met Pro Gln Ser Leu Gly Val Ile Gly Gly Lys
         195                 200                 205            
 Pro Asn Ser Ala His Tyr Phe Ile Gly Tyr Val Gly Glu Glu Leu Ile
     210                 215                 220                
 Tyr Leu Asp Pro His Thr Thr Gln Pro Ala Val Glu Pro Thr Asp Gly
 225                 230                 235                 240
 Cys Phe Ile Pro Asp Glu Ser Phe His Cys Gln His Pro Pro Cys Arg
                 245                 250                 255    
 Met Ser Ile Ala Glu Leu Asp Pro Ser Ile Ala Val Gly Phe Phe Cys
             260                 265                 270        
 Lys Thr Glu Asp Asp Phe Asn Asp Trp Cys Gln Gln Val Lys Lys Leu
         275                 280                 285            
 Ser Leu Leu Gly Gly Ala Leu Pro Met Phe Glu Leu Val Glu Gln Gln
     290                 295                 300                
 Pro Ser His Leu Ala Cys Pro Asp Val Leu Asn Leu Ser Leu Asp Ser
 305                 310                 315                 320
 Ser Asp Val Glu Arg Leu Glu Arg Phe Phe Asp Ser Glu Asp Glu Asp
                 325                 330                 335    
 Phe Glu Ile Leu Ser Leu
             340        



      <210> 1093
      <211> 249
      <212> PRT
      <213> Homo sapiens


      <400> 1093
 Met Ile Glu Val Leu Thr Thr Thr Asp Ser Gln Lys Leu Leu His Gln
   1               5                  10                  15    
 Leu Asn Ala Leu Leu Glu Gln Glu Ser Arg Cys Gln Pro Lys Val Cys
              20                  25                  30        
 Gly Leu Arg Leu Ile Glu Ser Ala His Asp Asn Gly Leu Arg Met Thr
          35                  40                  45            
 Ala Arg Leu Arg Asp Phe Glu Val Lys Asp Leu Leu Ser Leu Thr Gln
      50                  55                  60                
 Phe Phe Gly Phe Asp Thr Glu Thr Phe Ser Leu Ala Val Asn Leu Leu
  65                  70                  75                  80
 Asp Arg Phe Leu Ser Lys Met Lys Val Gln Pro Lys His Leu Gly Cys
                  85                  90                  95    
 Val Gly Leu Ser Cys Phe Tyr Leu Ala Val Lys Ser Ile Glu Glu Glu
             100                 105                 110        
 Arg Asn Val Pro Leu Ala Thr Asp Leu Ile Arg Ile Ser Gln Tyr Arg
         115                 120                 125            
 Phe Thr Val Ser Asp Leu Met Arg Met Glu Lys Ile Val Leu Glu Lys
     130                 135                 140                
 Val Cys Trp Lys Val Lys Ala Thr Thr Ala Phe Gln Phe Leu Gln Leu
 145                 150                 155                 160
 Tyr Tyr Ser Leu Leu Gln Glu Asn Leu Pro Leu Glu Arg Arg Asn Ser
                 165                 170                 175    
 Ile Asn Phe Glu Arg Leu Glu Ala Gln Leu Lys Ala Cys His Cys Arg
             180                 185                 190        
 Ile Ile Phe Ser Lys Ala Lys Pro Ser Val Trp His Val Tyr His Cys
         195                 200                 205            
 Ile Arg Asp Pro Ser Thr Glu Val Cys Arg Val Asn Arg Arg Asn Arg
     210                 215                 220                
 Met Ser Ser Glu Thr Phe Gln Asp Lys Trp Gln Arg Ser Asp Leu Leu
 225                 230                 235                 240
 Ala Arg Ala Cys Ile Gln Met Phe Asn
                 245                



      <210> 1094
      <211> 428
      <212> PRT
      <213> Homo sapiens


      <400> 1094
 Met Tyr Ser Asn Val Ile Gly Thr Val Thr Ser Gly Thr Cys His Gly
   1               5                  10                  15    
 Ser Pro Val Asp Ile Cys Thr Ala Lys Pro Arg Asp Ile Pro Met Asn
              20                  25                  30        
 Pro Met Cys Ile Tyr Arg Ser Pro Glu Lys Lys Ala Thr Glu Asp Glu
          35                  40                  45            
 Gly Ser Glu Gln Lys Ile Pro Glu Ala Thr Asn Arg Arg Val Trp Glu
      50                  55                  60                
 Leu Ser Lys Ala Asn Ser Arg Phe Ala Thr Thr Phe Tyr Gln His Leu
  65                  70                  75                  80
 Ala Asp Ser Lys Asn Asp Asn Asp Asn Ile Phe Leu Ser Pro Leu Ser
                  85                  90                  95    
 Ile Ser Thr Ala Phe Ala Met Thr Lys Leu Gly Ala Cys Asn Asp Thr
             100                 105                 110        
 Leu Gln Gln Leu Met Glu Val Phe Lys Phe Asp Thr Ile Ser Glu Lys
         115                 120                 125            
 Thr Ser Asp Gln Ile His Phe Phe Phe Ala Lys Leu Asn Cys Arg Leu
     130                 135                 140                
 Tyr Arg Lys Ala Asn Lys Ser Ser Lys Leu Val Ser Ala Asn Arg Leu
 145                 150                 155                 160
 Phe Gly Asp Lys Ser Leu Thr Phe Asn Glu Thr Tyr Gln Asp Ile Ser
                 165                 170                 175    
 Glu Leu Val Tyr Gly Ala Lys Leu Gln Pro Leu Asp Phe Lys Glu Gly
             180                 185                 190        
 Arg Ile Thr Asp Val Ile Pro Ser Glu Ala Ile Asn Glu Leu Thr Val
         195                 200                 205            
 Leu Val Leu Val Asn Thr Ile Tyr Phe Lys Gly Leu Trp Lys Ser Lys
     210                 215                 220                
 Phe Ser Pro Glu Asn Thr Arg Lys Glu Leu Phe Tyr Lys Ala Asp Gly
 225                 230                 235                 240
 Glu Ser Cys Ser Ala Ser Met Met Tyr Gln Glu Gly Lys Phe Arg Tyr
                 245                 250                 255    
 Arg Arg Val Ala Glu Ser Thr Gln Val Leu Glu Leu Pro Phe Lys Gly
             260                 265                 270        
 Asp Asp Ile Thr Met Val Leu Ile Leu Pro Lys Pro Glu Lys Ser Leu
         275                 280                 285            
 Ala Lys Val Glu Lys Glu Leu Thr Pro Glu Val Leu Gln Glu Trp Leu
     290                 295                 300                
 Asp Glu Leu Glu Glu Met Met Leu Val Val His Met Pro Arg Phe Arg
 305                 310                 315                 320
 Ile Glu Asp Arg Phe Ser Leu Lys Glu Gln Leu Gln Asp Met Gly Leu
                 325                 330                 335    
 Val Asp Leu Phe Ser Pro Glu Lys Ser Lys Leu Pro Gly Ile Val Ala
             340                 345                 350        
 Glu Gly Arg Asp Asp Leu Tyr Val Ser Asp Ala Phe His Lys Ala Phe
         355                 360                 365            
 Leu Glu Val Asn Glu Glu Gly Ser Glu Ala Ala Ala Ser Thr Ala Val
     370                 375                 380                
 Val Ile Ala Gly Arg Ser Leu Asn Pro Asn Arg Val Thr Phe Lys Ala
 385                 390                 395                 400
 Asn Arg Pro Phe Leu Val Phe Ile Arg Glu Val Pro Leu Asn Thr Ile
                 405                 410                 415    
 Ile Phe Met Gly Arg Val Ala Asn Pro Cys Val Lys
             420                 425            



      <210> 1095
      <211> 346
      <212> PRT
      <213> Homo sapiens


      <400> 1095
 Met Ser Met Phe Gln Met Arg Lys Leu Lys Asn Gly Glu Arg Ala Asn
   1               5                  10                  15    
 Glu Thr Val Ser Gln Ser Val Val Pro Lys Ser Pro His His Leu Ala
              20                  25                  30        
 Val Ser Tyr Leu Ser Ser Ser Leu Gln Pro Phe Phe Leu Ile Thr Pro
          35                  40                  45            
 Pro Val Ile Ile Thr His Ile Ile Ser Gly His Met Ala Lys His Arg
      50                  55                  60                
 Arg Asp Leu Ala Glu Gly His Ser Pro Glu Gln Val Leu Asp Thr Glu
  65                  70                  75                  80
 Pro Gly Thr Ala Glu Gly Leu His Cys Gln Lys Lys Gln Trp Pro His
                  85                  90                  95    
 Ser Pro Val Leu Pro Leu Leu Leu Val Leu Ser Ser Glu Gln Pro Pro
             100                 105                 110        
 Val Leu Arg Asp Phe Asn Ile Lys Leu Phe Tyr Phe Arg Phe Ser Lys
         115                 120                 125            
 Leu Cys Leu Arg Asp Asp Ser Gly Gln Gln Arg Leu Ser Lys Asn Phe
     130                 135                 140                
 Cys Gly Leu Val Ala Tyr Ala Ala Pro Glu Leu Leu Gln Gly Ile Pro
 145                 150                 155                 160
 Tyr Gln Pro Met Val Tyr Asp Ile Trp Ser Leu Gly Met Ile Leu Tyr
                 165                 170                 175    
 Ile Met Val Cys Ser Ser Met Pro Tyr Asp Ser Asn Ile Arg Lys Met
             180                 185                 190        
 Leu Arg Ile Gln Lys Glu His Arg Val Asp Phe Pro His Ser Lys Asn
         195                 200                 205            
 Leu Thr Asp Glu Cys Lys Asp Leu Ile Tyr Cys Met Leu Gln Pro Asp
     210                 215                 220                
 Val Ser Gln Arg Leu His Ile His Asp Thr Leu Ser Gln Cys Trp Val
 225                 230                 235                 240
 Gln Pro Lys Ala Gln Gly Leu Pro Ser Met Val Phe Asn Lys Glu Gly
                 245                 250                 255    
 Glu Ser Ser Gln Gly Thr Glu Leu Leu Trp Thr Pro Glu Pro Gly Ser
             260                 265                 270        
 Ala Lys Arg Ser Ala Thr Lys Leu Glu Pro Gly Glu Gln Thr Gln Pro
         275                 280                 285            
 Glu Gly Gln Pro Glu Thr Lys Pro Glu Gly Leu Ala Met Gln Met Ser
     290                 295                 300                
 Arg Gln Ser Asp Ile Leu Gly Phe Pro Ser Lys Pro Ser Thr Arg Glu
 305                 310                 315                 320
 Lys Glu Glu Gly Pro Pro Ser Ser Leu Gln Arg Cys Ala Pro Ser Glu
                 325                 330                 335    
 Pro Phe Val Ala Gln Cys Ala Ser Gly Glu
             340                 345    



      <210> 1096
      <211> 570
      <212> PRT
      <213> Homo sapiens


      <400> 1096
 Met Gln Glu Gly Lys Pro Asn Leu Leu Asp Met Gly Ser Leu Met Ile
   1               5                  10                  15    
 Lys Pro Ile Gln Arg Val Met Lys Tyr Pro Leu Leu Leu Cys Glu Leu
              20                  25                  30        
 Arg Asn Ser Thr Pro Pro Ser His Pro Asp Tyr Arg Ala Leu Asp Asp
          35                  40                  45            
 Ala Phe Ala Ala Val Lys Asp Ile Asn Val Asn Ile Asn Glu Leu Lys
      50                  55                  60                
 Arg Arg Lys Asp Leu Gly Glu Asn Val Leu Gly Ile Thr Ser Leu Glu
  65                  70                  75                  80
 Asn Asn Leu Thr Ile Pro Ser Lys Val Glu Asp Ala Gln Thr Gly Asp
                  85                  90                  95    
 Ser Glu Asn Glu Phe Leu Ser Ile Cys Pro Arg Glu Thr Leu Ala His
             100                 105                 110        
 Val Leu Lys Glu Arg Cys Thr Val Leu Lys Tyr Lys Lys Asn Asp Glu
         115                 120                 125            
 Asp Glu Ser Leu Lys Asp Lys Leu Ser Lys Leu Asn Ile His Ser Ile
     130                 135                 140                
 Ser Lys Lys Ser Lys Arg Val Thr Asn His Leu Lys Ile Leu Thr Arg
 145                 150                 155                 160
 Gly Glu Ser Gln Asp Ala Met Pro Leu Ala Leu Gln Ser Val Met Asp
                 165                 170                 175    
 Leu Gln Glu Ile Ser Tyr Asn Lys Asp Asp Glu Met Asp Tyr Ser Glu
             180                 185                 190        
 Thr Leu Ser Asn Ala Leu Asn Ser Cys His Asp Phe Ala Ser His Leu
         195                 200                 205            
 Gln Arg Leu Ile Leu Thr Pro Leu Ser Ala Leu Leu Ser Leu Phe Pro
     210                 215                 220                
 Gly Pro His Lys Leu Ile Gln Lys Arg Tyr Asp Lys Leu Leu Asp Cys
 225                 230                 235                 240
 Asn Ser Tyr Leu Gln Arg Ser Thr Gly Glu Glu Ser Asp Leu Ala Lys
                 245                 250                 255    
 Lys Glu Tyr Glu Ala Leu Asn Ala Gln Leu Val Glu Glu Leu Gln Ala
             260                 265                 270        
 Phe Asn Gln Ala Ala Arg Lys Ile Leu Leu Asn Cys Leu Cys Ser Phe
         275                 280                 285            
 Ile Thr Leu Leu Arg Asp Leu Met Leu Val Ala Gln Gln Ala Tyr Ser
     290                 295                 300                
 Thr Leu Val Pro Met Pro Leu Leu Val Ser Ser Ile Ser Glu Ile Gln
 305                 310                 315                 320
 Asn Gln Val Leu Glu Glu Ile Gln Asn Leu Asn Cys Val Lys Glu Asn
                 325                 330                 335    
 Ser Ala Thr Phe Ile Glu Arg Lys Leu Ser Phe Glu Lys Lys Lys Pro
             340                 345                 350        
 Val Gln Ile Leu Pro Glu Met Pro His Gln Thr Asp Ile His Arg Ser
         355                 360                 365            
 Lys Leu Leu Ser Thr Tyr Ser Ala Glu Glu Leu Tyr Gln Ala Lys Arg
     370                 375                 380                
 Lys Cys Asn Ala Thr Gln Glu Tyr Asp Ile Asn Leu Leu Glu Gly Asp
 385                 390                 395                 400
 Leu Val Ala Val Ile Glu Gln Lys Asp Pro Leu Gly Ser Thr Ser Arg
                 405                 410                 415    
 Trp Leu Val Asp Thr Gly Asn Val Lys Gly Tyr Val Tyr Ser Ser Phe
             420                 425                 430        
 Leu Lys Pro Tyr Asn Pro Ala Lys Met Gln Lys Val Asp Ala Glu Asn
         435                 440                 445            
 Arg Phe Cys Asp Asp Asp Phe Glu Asn Ile Ser Leu Phe Val Ser Ser
     450                 455                 460                
 Arg Pro Ala Ser Asp Ser Val Thr Gly Thr Ser Glu Ser Ser Ile Gly
 465                 470                 475                 480
 Asp Ser Ser Ser Ser Leu Ser Gly Thr Cys Gly Lys Phe Glu Thr Asn
                 485                 490                 495    
 Gly Thr Asp Val Asp Ser Phe Gln Glu Val Asp Glu Gln Ile Phe Tyr
             500                 505                 510        
 Ala Val His Ala Phe Gln Ala Arg Ser Asp His Glu Leu Ser Leu Gln
         515                 520                 525            
 Glu Tyr Gln Arg Val His Ile Leu Arg Phe Cys Asp Leu Ser Gly Asn
     530                 535                 540                
 Lys Glu Trp Trp Leu Ala Glu Ala Gln Gly Gln Lys Gly Tyr Val Pro
 545                 550                 555                 560
 Ala Asn Tyr Leu Gly Lys Met Thr Tyr Ala
                 565                 570



      <210> 1097
      <211> 89
      <212> PRT
      <213> Homo sapiens


      <400> 1097
 Met Cys Asp Arg Lys Ala Gly Ile Lys Asn Ala Asp Met Ser Glu Glu
   1               5                  10                  15    
 Met Leu Gln Asp Ser Val Asp Cys Ala Thr Gln Ala Leu Glu Asn Tyr
              20                  25                  30        
 His Ile Lys Lys Glu Ile Gly Ala His Ile Arg Lys Glu Phe Asp Lys
          35                  40                  45            
 Lys Tyr His Pro Thr Trp Arg Trp Val Lys Gly Arg Asn Phe Gly Ser
      50                  55                  60                
 Tyr Val Thr His Glu Thr Lys His Phe Ile Tyr Phe Tyr Leu Gly Gln
  65                  70                  75                  80
 Gly Gly Ile Leu Leu Phe Lys Phe Gly
                  85                



      <210> 1098
      <211> 51
      <212> PRT
      <213> Homo sapiens


      <400> 1098
 Met Asp Thr Ser Asn Asn Val Ile His Arg Val Gly Ser Ser Arg Ala
   1               5                  10                  15    
 Ala Pro Leu Phe Pro Ala Gly Gln Glu Cys Asp Phe Thr Val Lys Arg
              20                  25                  30        
 His Val Gln Val Thr Leu Tyr Val Ala Met Pro Ala Thr His Lys Lys
          35                  40                  45            
 Gly Gly Leu
      50    



      <210> 1099
      <211> 1032
      <212> PRT
      <213> Homo sapiens


      <400> 1099
 Met Pro Gly Val Ser Gln Glu Ser Thr Ala Ser His Ser Ser Pro Gly
   1               5                  10                  15    
 Ser Thr Asp Thr Thr Leu Ser Pro Gly Ser Thr Thr Ala Ser Ser Leu
              20                  25                  30        
 Gly Pro Glu Ser Thr Thr Phe His Ser Gly Pro Gly Ser Thr Glu Thr
          35                  40                  45            
 Thr Leu Leu Pro Asp Asn Thr Thr Ala Ser Gly Leu Leu Glu Ala Ser
      50                  55                  60                
 Thr Pro Val His Ser Ser Thr Gly Ser Pro His Thr Thr Leu Ser Pro
  65                  70                  75                  80
 Ala Gly Ser Thr Thr Arg Gln Gly Glu Ser Thr Thr Phe Gln Ser Trp
                  85                  90                  95    
 Pro Asn Ser Lys Asp Thr Thr Pro Ala Pro Pro Thr Thr Thr Ser Ala
             100                 105                 110        
 Phe Val Glu Leu Ser Thr Thr Ser His Gly Ser Pro Ser Ser Thr Pro
         115                 120                 125            
 Thr Thr His Phe Ser Ala Ser Ser Thr Thr Leu Gly Arg Ser Glu Glu
     130                 135                 140                
 Ser Thr Thr Val His Ser Ser Pro Val Ala Thr Ala Thr Thr Pro Ser
 145                 150                 155                 160
 Pro Ala Arg Ser Thr Thr Ser Gly Leu Val Glu Glu Ser Thr Thr Tyr
                 165                 170                 175    
 His Ser Ser Pro Gly Ser Thr Gln Thr Met His Phe Pro Glu Ser Asp
             180                 185                 190        
 Thr Thr Ser Gly Arg Gly Glu Glu Ser Thr Thr Ser His Ser Ser Thr
         195                 200                 205            
 Thr His Thr Ile Ser Ser Ala Pro Ser Thr Thr Ser Ala Leu Val Glu
     210                 215                 220                
 Glu Pro Thr Ser Tyr His Ser Ser Pro Gly Ser Thr Ala Thr Thr His
 225                 230                 235                 240
 Phe Pro Asp Ser Ser Thr Thr Ser Gly Arg Ser Glu Glu Ser Thr Ala
                 245                 250                 255    
 Ser His Ser Ser Gln Asp Ala Thr Gly Thr Ile Val Leu Pro Ala Arg
             260                 265                 270        
 Ser Thr Thr Ser Val Leu Leu Gly Glu Ser Thr Thr Ser Pro Ile Ser
         275                 280                 285            
 Ser Gly Ser Met Glu Thr Thr Ala Leu Pro Gly Ser Thr Thr Thr Pro
     290                 295                 300                
 Gly Leu Ser Glu Lys Ser Thr Thr Phe His Ser Ser Pro Arg Ser Pro
 305                 310                 315                 320
 Ala Thr Thr Leu Ser Pro Ala Ser Thr Thr Ser Ser Gly Val Ser Glu
                 325                 330                 335    
 Glu Ser Thr Thr Ser His Ser Arg Pro Gly Ser Thr His Thr Thr Ala
             340                 345                 350        
 Phe Pro Asp Ser Thr Thr Thr Pro Gly Leu Ser Arg His Ser Thr Thr
         355                 360                 365            
 Ser His Ser Ser Pro Gly Ser Thr Asp Thr Thr Leu Leu Pro Ala Ser
     370                 375                 380                
 Thr Thr Thr Ser Gly Pro Ser Gln Glu Ser Thr Thr Ser His Ser Ser
 385                 390                 395                 400
 Pro Gly Ser Thr Asp Thr Ala Leu Ser Pro Gly Ser Thr Thr Ala Leu
                 405                 410                 415    
 Ser Phe Gly Gln Glu Ser Thr Thr Phe His Ser Ser Pro Gly Ser Thr
             420                 425                 430        
 His Thr Thr Leu Phe Pro Asp Ser Thr Thr Ser Ser Gly Ile Val Glu
         435                 440                 445            
 Ala Ser Thr Arg Val His Ser Ser Thr Gly Ser Pro Arg Thr Thr Leu
     450                 455                 460                
 Ser Pro Ala Ser Ser Thr Ser Pro Gly Leu Gln Gly Glu Ser Thr Ala
 465                 470                 475                 480
 Phe Gln Thr His Pro Ala Ser Thr His Thr Thr Pro Ser Pro Pro Ser
                 485                 490                 495    
 Thr Ala Thr Ala Pro Val Glu Glu Ser Thr Thr Tyr His Arg Ser Pro
             500                 505                 510        
 Gly Ser Thr Pro Thr Thr His Phe Pro Ala Ser Ser Thr Thr Ser Gly
         515                 520                 525            
 His Ser Glu Lys Ser Thr Ile Phe His Ser Ser Pro Asp Ala Ser Gly
     530                 535                 540                
 Thr Thr Pro Ser Ser Ala His Ser Thr Thr Ser Gly Arg Gly Glu Ser
 545                 550                 555                 560
 Thr Thr Ser Arg Ile Ser Pro Gly Ser Thr Glu Ile Thr Thr Leu Pro
                 565                 570                 575    
 Gly Ser Thr Thr Thr Pro Gly Leu Ser Glu Ala Ser Thr Thr Phe Tyr
             580                 585                 590        
 Ser Ser Pro Arg Ser Pro Thr Thr Thr Leu Ser Pro Ala Ser Met Thr
         595                 600                 605            
 Ser Leu Gly Val Gly Glu Glu Ser Thr Thr Ser Arg Ser Gln Pro Gly
     610                 615                 620                
 Ser Thr His Ser Thr Val Ser Pro Ala Ser Thr Thr Thr Pro Gly Leu
 625                 630                 635                 640
 Ser Glu Glu Ser Thr Thr Val Tyr Ser Ser Ser Pro Gly Ser Thr Glu
                 645                 650                 655    
 Thr Thr Val Phe Pro Arg Ser Thr Thr Thr Ser Val Arg Gly Glu Glu
             660                 665                 670        
 Pro Thr Thr Phe His Ser Arg Pro Ala Ser Thr His Thr Thr Leu Phe
         675                 680                 685            
 Thr Glu Asp Ser Thr Thr Ser Gly Leu Thr Glu Glu Ser Thr Ala Phe
     690                 695                 700                
 Pro Gly Ser Pro Ala Ser Thr Gln Thr Gly Leu Pro Ala Thr Leu Thr
 705                 710                 715                 720
 Thr Ala Asp Leu Gly Glu Glu Ser Thr Thr Phe Pro Ser Ser Ser Gly
                 725                 730                 735    
 Ser Thr Gly Thr Thr Leu Ser Pro Ala Arg Ser Thr Thr Ser Gly Leu
             740                 745                 750        
 Val Gly Glu Ser Thr Pro Ser Arg Leu Ser Pro Ser Ser Thr Glu Thr
         755                 760                 765            
 Thr Thr Leu Pro Gly Ser Pro Thr Thr Pro Ser Leu Ser Glu Lys Ser
     770                 775                 780                
 Thr Thr Phe Tyr Thr Ser Pro Arg Ser Pro Asp Ala Thr Leu Ser Pro
 785                 790                 795                 800
 Ala Thr Thr Thr Ser Ser Gly Val Ser Glu Glu Ser Ser Thr Ser His
                 805                 810                 815    
 Ser Gln Pro Gly Ser Thr His Thr Thr Ala Phe Pro Asp Ser Thr Thr
             820                 825                 830        
 Thr Ser Gly Leu Ser Gln Glu Pro Thr Thr Ser His Ser Ser Gln Gly
         835                 840                 845            
 Ser Thr Glu Ala Thr Leu Ser Pro Gly Ser Thr Thr Ala Ser Ser Leu
     850                 855                 860                
 Gly Gln Gln Ser Thr Thr Phe His Ser Ser Pro Gly Asp Thr Glu Thr
 865                 870                 875                 880
 Thr Leu Leu Pro Asp Asp Thr Ile Thr Ser Gly Leu Val Glu Ala Ser
                 885                 890                 895    
 Thr Pro Thr His Ser Ser Thr Gly Ser Leu His Thr Thr Leu Thr Pro
             900                 905                 910        
 Ala Ser Ser Thr Ser Ala Gly Leu Gln Glu Glu Ser Thr Thr Phe Gln
         915                 920                 925            
 Ser Trp Pro Ser Ser Ser Asp Thr Thr Pro Ser Pro Pro Gly Thr Thr
     930                 935                 940                
 Ala Ala Pro Val Glu Val Ser Thr Thr Tyr His Ser Arg Pro Ser Ser
 945                 950                 955                 960
 Thr Pro Thr Thr His Phe Ser Ala Ser Ser Thr Thr Leu Gly Arg Ser
                 965                 970                 975    
 Glu Glu Ser Thr Thr Val His Ser Ser Pro Gly Ala Thr Gly Thr Ala
             980                 985                 990        
 Leu Phe Pro Thr Arg Ser Ala Thr Ser Val Leu Val Gly Glu Pro Thr
         995                1000                1005            
 Met Ser Pro His Gln Phe Arg Leu Asn Gly Asn Asn Ser Val Thr Trp
    1010                1015                1020                
 Gln Tyr His Tyr Ser Arg Pro Glu
1025                1030        



      <210> 1100
      <211> 1004
      <212> PRT
      <213> Homo sapiens


      <400> 1100
 Met Pro Gly Val Ser Gln Glu Ser Thr Ala Ser His Ser Ser Pro Gly
   1               5                  10                  15    
 Ser Thr Asp Thr Thr Leu Ser Pro Gly Ser Thr Thr Ala Ser Ser Leu
              20                  25                  30        
 Gly Pro Glu Ser Thr Thr Phe His Ser Gly Pro Gly Ser Thr Glu Thr
          35                  40                  45            
 Thr Leu Leu Pro Asp Asn Thr Thr Ala Ser Gly Leu Leu Glu Ala Ser
      50                  55                  60                
 Thr Pro Val His Ser Ser Thr Gly Ser Pro His Thr Thr Leu Ser Pro
  65                  70                  75                  80
 Ala Gly Ser Thr Thr Arg Gln Gly Glu Ser Thr Thr Phe Gln Ser Trp
                  85                  90                  95    
 Pro Asn Ser Lys Asp Thr Thr Pro Ala Pro Pro Thr Thr Thr Ser Ala
             100                 105                 110        
 Phe Val Glu Leu Ser Thr Thr Ser His Gly Ser Pro Ser Ser Thr Pro
         115                 120                 125            
 Thr Thr His Phe Ser Ala Ser Ser Thr Thr Leu Gly Arg Ser Glu Glu
     130                 135                 140                
 Ser Thr Thr Val His Ser Ser Pro Val Ala Thr Ala Thr Thr Pro Ser
 145                 150                 155                 160
 Pro Ala Arg Ser Thr Thr Ser Gly Leu Val Glu Glu Ser Thr Thr Tyr
                 165                 170                 175    
 His Ser Ser Pro Gly Ser Thr Gln Thr Met His Phe Pro Glu Ser Asp
             180                 185                 190        
 Thr Thr Ser Gly Arg Gly Glu Glu Ser Thr Thr Ser His Ser Ser Thr
         195                 200                 205            
 Thr His Thr Ile Ser Ser Ala Pro Ser Thr Thr Ser Ala Leu Val Glu
     210                 215                 220                
 Glu Pro Thr Ser Tyr His Ser Ser Pro Gly Ser Thr Ala Thr Thr His
 225                 230                 235                 240
 Phe Pro Asp Ser Ser Thr Thr Ser Gly Arg Ser Glu Glu Ser Thr Ala
                 245                 250                 255    
 Ser His Ser Ser Gln Asp Ala Thr Gly Thr Ile Val Leu Pro Ala Arg
             260                 265                 270        
 Ser Thr Thr Ser Val Leu Leu Gly Glu Ser Thr Thr Ser Pro Ile Ser
         275                 280                 285            
 Ser Gly Ser Met Glu Thr Thr Ala Leu Pro Gly Ser Thr Thr Thr Pro
     290                 295                 300                
 Gly Leu Ser Glu Lys Ser Thr Thr Phe His Ser Ser Pro Arg Ser Pro
 305                 310                 315                 320
 Ala Thr Thr Leu Ser Pro Ala Ser Thr Thr Ser Ser Gly Val Ser Glu
                 325                 330                 335    
 Glu Ser Thr Thr Ser His Ser Arg Pro Gly Ser Thr His Thr Thr Ala
             340                 345                 350        
 Phe Pro Asp Ser Thr Thr Thr Pro Gly Leu Ser Gln Glu Ser Thr Thr
         355                 360                 365            
 Ser His Ser Ser Pro Gly Ser Thr Asp Thr Ala Leu Ser Pro Gly Ser
     370                 375                 380                
 Thr Thr Ala Leu Ser Phe Gly Gln Glu Ser Thr Thr Phe His Ser Ser
 385                 390                 395                 400
 Pro Gly Ser Thr His Thr Thr Leu Phe Pro Asp Ser Thr Thr Ser Ser
                 405                 410                 415    
 Gly Ile Val Glu Ala Ser Thr Arg Val His Ser Ser Thr Gly Ser Pro
             420                 425                 430        
 Arg Thr Thr Leu Ser Pro Ala Ser Ser Thr Ser Pro Gly Leu Gln Gly
         435                 440                 445            
 Glu Ser Thr Ala Phe Gln Thr His Pro Ala Ser Thr His Thr Thr Pro
     450                 455                 460                
 Ser Pro Pro Ser Thr Ala Thr Ala Pro Val Glu Glu Ser Thr Thr Tyr
 465                 470                 475                 480
 His Arg Ser Pro Gly Ser Thr Pro Thr Thr His Phe Pro Ala Ser Ser
                 485                 490                 495    
 Thr Thr Ser Gly His Ser Glu Lys Ser Thr Ile Phe His Ser Ser Pro
             500                 505                 510        
 Asp Ala Ser Gly Thr Thr Pro Ser Ser Ala His Ser Thr Thr Ser Gly
         515                 520                 525            
 Arg Gly Glu Ser Thr Thr Ser Arg Ile Ser Pro Gly Ser Thr Glu Ile
     530                 535                 540                
 Thr Thr Leu Pro Gly Ser Thr Thr Thr Pro Gly Leu Ser Glu Ala Ser
 545                 550                 555                 560
 Thr Thr Phe Tyr Ser Ser Pro Arg Ser Pro Thr Thr Thr Leu Ser Pro
                 565                 570                 575    
 Ala Ser Met Thr Ser Leu Gly Val Gly Glu Glu Ser Thr Thr Ser Arg
             580                 585                 590        
 Ser Gln Pro Gly Ser Thr His Ser Thr Val Ser Pro Ala Ser Thr Thr
         595                 600                 605            
 Thr Pro Gly Leu Ser Glu Glu Ser Thr Thr Val Tyr Ser Ser Ser Pro
     610                 615                 620                
 Gly Ser Thr Glu Thr Thr Val Phe Pro Arg Ser Thr Thr Thr Ser Val
 625                 630                 635                 640
 Arg Gly Glu Glu Pro Thr Thr Phe His Ser Arg Pro Ala Ser Thr His
                 645                 650                 655    
 Thr Thr Leu Phe Thr Glu Asp Ser Thr Thr Ser Gly Leu Thr Glu Glu
             660                 665                 670        
 Ser Thr Ala Phe Pro Gly Ser Pro Ala Ser Thr Gln Thr Gly Leu Pro
         675                 680                 685            
 Ala Thr Leu Thr Thr Ala Asp Leu Gly Glu Glu Ser Thr Thr Phe Pro
     690                 695                 700                
 Ser Ser Ser Gly Ser Thr Gly Thr Thr Leu Ser Pro Ala Arg Ser Thr
 705                 710                 715                 720
 Thr Ser Gly Leu Val Gly Glu Ser Thr Pro Ser Arg Leu Ser Pro Ser
                 725                 730                 735    
 Ser Thr Glu Thr Thr Thr Leu Pro Gly Ser Pro Thr Thr Pro Ser Leu
             740                 745                 750        
 Ser Glu Lys Ser Thr Thr Phe Tyr Thr Ser Pro Arg Ser Pro Asp Ala
         755                 760                 765            
 Thr Leu Ser Pro Ala Thr Thr Thr Ser Ser Gly Val Ser Glu Glu Ser
     770                 775                 780                
 Ser Thr Ser His Ser Gln Pro Gly Ser Thr His Thr Thr Ala Phe Pro
 785                 790                 795                 800
 Asp Ser Thr Thr Thr Ser Gly Leu Ser Gln Glu Pro Thr Thr Ser His
                 805                 810                 815    
 Ser Ser Gln Gly Ser Thr Glu Ala Thr Leu Ser Pro Gly Ser Thr Thr
             820                 825                 830        
 Ala Ser Ser Leu Gly Gln Gln Ser Thr Thr Phe His Ser Ser Pro Gly
         835                 840                 845            
 Asp Thr Glu Thr Thr Leu Leu Pro Asp Asp Thr Ile Thr Ser Gly Leu
     850                 855                 860                
 Val Glu Ala Ser Thr Pro Thr His Ser Ser Thr Gly Ser Leu His Thr
 865                 870                 875                 880
 Thr Leu Thr Pro Ala Ser Ser Thr Ser Ala Gly Leu Gln Glu Glu Ser
                 885                 890                 895    
 Thr Thr Phe Gln Ser Trp Pro Ser Ser Ser Asp Thr Thr Pro Ser Pro
             900                 905                 910        
 Pro Gly Thr Thr Ala Ala Pro Val Glu Val Ser Thr Thr Tyr His Ser
         915                 920                 925            
 Arg Pro Ser Ser Thr Pro Thr Thr His Phe Ser Ala Ser Ser Thr Thr
     930                 935                 940                
 Leu Gly Arg Ser Glu Glu Ser Thr Thr Val His Ser Ser Pro Gly Ala
 945                 950                 955                 960
 Thr Gly Thr Ala Leu Phe Pro Thr Arg Ser Ala Thr Ser Val Leu Val
                 965                 970                 975    
 Gly Glu Pro Thr Met Ser Pro His Gln Phe Arg Leu Asn Gly Asn Asn
             980                 985                 990        
 Ser Val Thr Trp Gln Tyr His Tyr Ser Arg Pro Glu
         995                1000                



      <210> 1101
      <211> 156
      <212> PRT
      <213> Homo sapiens


      <400> 1101
 Met Thr Glu Arg Leu Ser Ala Glu Gln Ile Lys Glu Tyr Lys Gly Val
   1               5                  10                  15    
 Phe Glu Met Phe Asp Glu Glu Gly Asn Gly Glu Val Lys Thr Gly Glu
              20                  25                  30        
 Leu Glu Trp Leu Met Ser Leu Leu Gly Ile Asn Pro Thr Lys Ser Glu
          35                  40                  45            
 Leu Ala Ser Met Ala Lys Asp Val Asp Arg Asp Asn Lys Gly Phe Phe
      50                  55                  60                
 Asn Cys Asp Gly Phe Leu Ala Leu Met Gly Val Tyr His Glu Lys Ala
  65                  70                  75                  80
 Gln Asn Gln Glu Ser Glu Leu Arg Ala Ala Phe Arg Val Phe Asp Lys
                  85                  90                  95    
 Glu Gly Lys Gly Tyr Ile Asp Trp Asn Thr Leu Lys Tyr Val Leu Met
             100                 105                 110        
 Asn Ala Gly Glu Pro Leu Asn Glu Val Glu Ala Glu Gln Met Met Lys
         115                 120                 125            
 Glu Ala Asp Lys Asp Gly Asp Arg Thr Ile Asp Tyr Glu Glu Phe Val
     130                 135                 140                
 Ala Met Met Thr Gly Glu Ser Phe Lys Leu Ile Gln
 145                 150                 155    



      <210> 1102
      <211> 124
      <212> PRT
      <213> Homo sapiens


      <400> 1102
 Met Gln Met Pro Val Arg Glu Thr Arg Arg Gln Ile Tyr Leu Asp Ala
   1               5                  10                  15    
 Gln Asn Glu Val Gln Gly Gly Glu Trp Leu Tyr Val Tyr Gln Pro Phe
              20                  25                  30        
 Ser Thr Thr Asp Ile Phe Asn Cys Lys Gln His Thr Pro Ser Tyr Thr
          35                  40                  45            
 Glu Lys Pro Gln Ala Leu Ile Asp Leu Met Leu Ser Ile Phe Leu Thr
      50                  55                  60                
 His Ser Pro Thr Trp Ala Asp Cys Lys Gln Leu Leu Leu Ser Leu Phe
  65                  70                  75                  80
 Asn Thr Glu Glu Arg Cys Arg Val Ile Gln Val Ala Asn Gln Trp Leu
                  85                  90                  95    
 Glu Ser Asn Thr Pro Val Gly Met Ala Asp Val Lys Gln Tyr Ala Gln
             100                 105                 110        
 Gln Thr Leu Pro Ile Glu Thr Asp Pro Gly Trp Asp
         115                 120                



      <210> 1103
      <211> 358
      <212> PRT
      <213> Homo sapiens


      <400> 1103
 Met Ala Gly Gln Gly Asp Cys Cys Val Lys Val Ala Val Arg Ile Arg
   1               5                  10                  15    
 Pro Gln Leu Ser Lys Glu Lys Ile Glu Gly Cys His Ile Cys Thr Ser
              20                  25                  30        
 Val Thr Pro Gly Glu Pro Gln Val Leu Leu Gly Lys Asp Lys Ala Phe
          35                  40                  45            
 Thr Tyr Asp Phe Val Phe Asp Leu Asp Thr Trp Gln Glu Gln Ile Tyr
      50                  55                  60                
 Ser Thr Cys Val Ser Lys Leu Ile Glu Gly Cys Phe Glu Gly Tyr Asn
  65                  70                  75                  80
 Ala Thr Val Leu Ala Tyr Gly Gln Thr Gly Ala Gly Lys Thr Tyr Thr
                  85                  90                  95    
 Met Gly Thr Gly Phe Asp Met Ala Thr Ser Glu Glu Glu Gln Gly Ile
             100                 105                 110        
 Ile Pro Arg Ala Ile Ala His Leu Phe Gly Gly Ile Ala Glu Arg Lys
         115                 120                 125            
 Arg Arg Ala Gln Glu Gln Gly Val Ala Gly Pro Glu Phe Lys Val Ser
     130                 135                 140                
 Ala Gln Phe Leu Glu Leu Tyr Asn Glu Glu Ile Leu Asp Leu Phe Asp
 145                 150                 155                 160
 Ser Thr Arg Asp Pro Asp Thr Arg His Arg Arg Ser Asn Ile Lys Ile
                 165                 170                 175    
 His Glu Asp Ala Asn Gly Gly Ile Tyr Thr Thr Gly Val Thr Ser Arg
             180                 185                 190        
 Leu Ile His Ser Gln Glu Glu Leu Ile Gln Cys Leu Lys Gln Gly Ala
         195                 200                 205            
 Leu Ser Arg Thr Thr Ala Ser Thr Gln Met Asn Val Gln Ser Ser Arg
     210                 215                 220                
 Ser His Ala Ile Phe Thr Ile His Leu Cys Gln Met Arg Met Cys Thr
 225                 230                 235                 240
 Gln Pro Asp Leu Val Asn Glu Ala Val Thr Gly Leu Pro Asp Gly Thr
                 245                 250                 255    
 Pro Pro Ser Ser Glu Tyr Glu Thr Leu Thr Ala Lys Phe His Phe Val
             260                 265                 270        
 Asp Leu Ala Gly Ser Glu Arg Leu Lys Arg Thr Gly Ala Thr Gly Glu
         275                 280                 285            
 Arg Ala Lys Glu Gly Ile Ser Ile Asn Cys Gly Leu Leu Ala Leu Gly
     290                 295                 300                
 Asn Val Ile Ser Ala Leu Gly Asp Gln Ser Lys Lys Val Val His Val
 305                 310                 315                 320
 Pro Tyr Arg Asp Ser Lys Leu Thr Arg Leu Leu Gln Asp Ser Leu Gly
                 325                 330                 335    
 Gly Asn Arg Tyr Leu Val Thr Asn Thr Gln Gly Arg Asp Arg Gly Gly
             340                 345                 350        
 Arg Glu Val Pro Gly Lys
         355            



      <210> 1104
      <211> 191
      <212> PRT
      <213> Homo sapiens


      <400> 1104
 Met Ala Ala Met Gly Gly Leu Thr Glu Pro Val Pro Thr Leu Asp Leu
   1               5                  10                  15    
 Gly Lys Lys Leu Ser Val Pro Gln Asp Leu Met Met Glu Glu Leu Ser
              20                  25                  30        
 Leu Arg Asn Asn Arg Gly Ser Leu Leu Phe Gln Lys Arg Gln Arg Arg
          35                  40                  45            
 Val Gln Lys Phe Thr Phe Glu Leu Ala Ala Ser Gln Arg Ala Val Asn
      50                  55                  60                
 Ala Gly Arg Lys Arg Gln Glu Glu Gly Asp Trp Asn Ser Gly Val Gly
  65                  70                  75                  80
 Asp Gly Tyr Ala Glu Pro Leu Lys Gly Val Pro Pro Glu Lys Phe Asn
                  85                  90                  95    
 His Thr Ala Ile Ser Lys Gly Tyr Arg Cys Pro Trp Gln Glu Phe Val
             100                 105                 110        
 Ser Tyr Arg Asp Tyr Gln Ser Asp Gly Arg Ser His Thr Pro Ser Pro
         115                 120                 125            
 Asn Asp Tyr Arg Asn Phe Asn Lys Thr Pro Val Pro Phe Gly Gly Pro
     130                 135                 140                
 Leu Val Gly Gly Thr Phe Pro Arg Pro Gly Thr Pro Phe Ile Pro Glu
 145                 150                 155                 160
 Pro Leu Ser Gly Leu Glu Leu Leu Arg Leu Arg Pro Ser Phe Asn Arg
                 165                 170                 175    
 Val Ala Gln Gly Trp Val Arg Asn Leu Pro Glu Ser Glu Glu Leu
             180                 185                 190    



      <210> 1105
      <211> 527
      <212> PRT
      <213> Homo sapiens


      <400> 1105
 Met Ala Lys Glu Arg Cys Leu Lys Lys Ser Phe Gln Asp Ser Leu Glu
   1               5                  10                  15    
 Asp Ile Lys Lys Arg Met Lys Glu Lys Arg Asn Lys Asn Leu Ala Glu
              20                  25                  30        
 Ile Gly Lys Arg Arg Ser Phe Ile Ala Ala Pro Cys Gln Ile Ile Thr
          35                  40                  45            
 Asn Thr Ser Thr Leu Leu Lys Asn Tyr Gln Asp Asn Asn Lys Met Leu
      50                  55                  60                
 Val Leu Ala Leu Glu Asn Glu Lys Ser Lys Val Lys Glu Ala Gln Asp
  65                  70                  75                  80
 Ile Ile Leu Gln Leu Arg Lys Glu Cys Tyr Tyr Leu Thr Cys Gln Leu
                  85                  90                  95    
 Tyr Ala Leu Lys Gly Lys Leu Thr Ser Gln Gln Thr Val Glu Pro Ala
             100                 105                 110        
 Gln Asn Gln Glu Ile Cys Ser Ser Gly Met Asp Pro Asn Ser Asp Asp
         115                 120                 125            
 Ser Ser Arg Asn Leu Phe Val Lys Asp Leu Pro Gln Ile Pro Leu Glu
     130                 135                 140                
 Glu Thr Glu Leu Pro Gly Gln Gly Glu Ser Phe Gln Ile Glu Asp Gln
 145                 150                 155                 160
 Ile Pro Thr Ile Pro Gln Asp Thr Leu Gly Val Asp Phe Asp Ser Gly
                 165                 170                 175    
 Glu Ala Lys Ser Thr Asp Asn Val Leu Pro Arg Thr Val Ser Val Arg
             180                 185                 190        
 Ser Ser Leu Lys Lys His Cys Asn Ser Ile Cys Gln Phe Asp Ser Leu
         195                 200                 205            
 Asp Asp Phe Glu Thr Ser His Leu Ala Gly Lys Ser Phe Glu Phe Glu
     210                 215                 220                
 Arg Val Gly Phe Leu Asp Pro Leu Val Asn Met His Ile Pro Glu Asn
 225                 230                 235                 240
 Val Gln His Asn Ala Cys Gln Trp Ser Lys Asp Gln Val Asn Leu Ser
                 245                 250                 255    
 Pro Lys Leu Ile Gln Pro Gly Thr Phe Thr Lys Thr Lys Glu Asp Ile
             260                 265                 270        
 Leu Glu Ser Lys Ser Glu Gln Thr Lys Ser Lys Gln Arg Asp Thr Gln
         275                 280                 285            
 Glu Arg Lys Arg Glu Glu Lys Arg Lys Ala Asn Arg Arg Lys Ser Lys
     290                 295                 300                
 Arg Met Ser Lys Tyr Lys Glu Asn Lys Ser Glu Asn Lys Lys Thr Val
 305                 310                 315                 320
 Pro Gln Lys Lys Met His Lys Ser Val Ser Ser Asn Asp Ala Tyr Asn
                 325                 330                 335    
 Phe Asn Leu Glu Glu Gly Val His Leu Thr Pro Phe Arg Gln Lys Val
             340                 345                 350        
 Ser Asn Asp Ser Asn Arg Glu Glu Asn Asn Glu Ser Glu Val Ser Leu
         355                 360                 365            
 Cys Glu Ser Ser Gly Ser Gly Asp Asp Ser Asp Asp Leu Tyr Leu Pro
     370                 375                 380                
 Thr Cys Lys Tyr Ile Gln Asn Pro Thr Ser Asn Ser Asp Arg Pro Val
 385                 390                 395                 400
 Thr Arg Pro Leu Ala Lys Arg Ala Leu Lys Tyr Thr Asp Glu Lys Glu
                 405                 410                 415    
 Thr Glu Gly Ser Lys Pro Thr Lys Thr Pro Thr Thr Thr Pro Pro Glu
             420                 425                 430        
 Thr Gln Gln Ser Pro His Leu Ser Leu Lys Asp Ile Thr Asn Val Ser
         435                 440                 445            
 Leu Tyr Pro Val Val Lys Ile Arg Arg Leu Ser Leu Ser Pro Lys Lys
     450                 455                 460                
 Asn Lys Ala Ser Pro Ala Val Ala Leu Pro Lys Arg Arg Cys Thr Ala
 465                 470                 475                 480
 Ser Val Asn Tyr Lys Glu Pro Thr Leu Ala Ser Lys Leu Arg Arg Gly
                 485                 490                 495    
 Asp Pro Phe Thr Asp Leu Cys Phe Leu Asn Ser Pro Ile Phe Lys Gln
             500                 505                 510        
 Lys Lys Asp Leu Arg Arg Ser Lys Lys Ser Met Lys Gln Ile Gln
         515                 520                 525        



      <210> 1106
      <211> 255
      <212> PRT
      <213> Homo sapiens


      <400> 1106
 Met Asp Lys Met Val Gln Glu Lys Asn Thr Ala Gly Ala Leu Gly Leu
   1               5                  10                  15    
 Leu Thr Glu Leu Gln Asn Val Leu Glu Leu Leu Arg Ser Thr Gly Thr
              20                  25                  30        
 Gly Met Leu Leu Asn Val Ser Leu Lys Gln Ser Ala Asp Glu Glu Val
          35                  40                  45            
 Thr Ser Leu Ala Lys Ser Leu Val Lys Ser Trp Lys Lys Leu Pro Asp
      50                  55                  60                
 Lys Pro Ser Ser Glu Lys Asp Pro Lys Glu Lys Gln Ile Glu Pro Ala
  65                  70                  75                  80
 Met Thr Ser Gln Asn Ser Lys Arg Asn Thr Ser Asp Ser Val Arg Met
                  85                  90                  95    
 Lys Tyr Arg Glu Met Leu Pro Ala Ala Leu Arg Thr Gly Asp Asp Cys
             100                 105                 110        
 Ile Glu Met Gly Thr Asp Glu Glu Glu Leu Gly Ser Arg Thr Glu Glu
         115                 120                 125            
 Ala Ile Asp Pro Glu Arg Gly Asn Thr Gly Met Lys Tyr Lys Asn Arg
     130                 135                 140                
 Val Gln Ser Lys Ile Ser Asn Leu Thr Asp Ala Lys Asn Pro Asp Leu
 145                 150                 155                 160
 Arg Lys Asn Ala Pro Cys Gly Asn Ile Pro Pro Asp Leu Leu Ala Arg
                 165                 170                 175    
 Met Thr Ala Glu Glu Met Ala Ser Asp Glu Leu Lys Glu Met His Lys
             180                 185                 190        
 Asn Leu Thr Lys Glu Ala Ile Arg Glu His Gln Met Ala Lys Thr Gly
         195                 200                 205            
 Gly Thr Gln Pro Asp Ser Leu Thr Cys Ala Lys Cys Lys Lys Lys Asn
     210                 215                 220                
 Cys Thr Ser Thr Gln Val Gln Ala Cys Ser Ala Gly Glu Pro Met Thr
 225                 230                 235                 240
 Thr Phe Val Asp Cys Asn Glu Cys Gly Asn Gln Gln Lys Phe Cys
                 245                 250                 255



      <210> 1107
      <211> 390
      <212> PRT
      <213> Homo sapiens


      <400> 1107
 Met Ala Glu Thr Lys Asp Ala Ala Gln Met Leu Val Thr Phe Lys Asp
   1               5                  10                  15    
 Val Ala Val Thr Phe Thr Arg Glu Glu Trp Arg Gln Leu Asp Leu Ala
              20                  25                  30        
 Gln Arg Thr Leu Tyr Arg Glu Val Met Leu Glu Thr Cys Gly Leu Leu
          35                  40                  45            
 Val Ser Leu Gly Asp Arg Ala Gln Val His Thr Arg Glu Pro Thr Thr
      50                  55                  60                
 Tyr Pro Pro Val Leu Ser Glu Arg Ala Phe Leu Arg Gly Ser Leu Thr
  65                  70                  75                  80
 Leu Glu Ser Ser Thr Ser Ser Asp Ser Arg Leu Gly Arg Ala Arg Asp
                  85                  90                  95    
 Glu Glu Gly Leu Leu Glu Met Gln Lys Gly Lys Val Thr Pro Glu Thr
             100                 105                 110        
 Asp Leu His Lys Glu Thr His Leu Gly Lys Val Ser Leu Glu Gly Glu
         115                 120                 125            
 Gly Leu Gly Thr Asp Asp Gly Leu His Ser Arg Ala Leu Gln Glu Trp
     130                 135                 140                
 Leu Ser Ala Asp Val Leu His Glu Cys Asp Ser Gln Gln Pro Gly Lys
 145                 150                 155                 160
 Asp Ala Leu Ile His Ala Gly Thr Asn Pro Tyr Lys Cys Lys Gln Cys
                 165                 170                 175    
 Gly Lys Gly Phe Asn Arg Lys Trp Tyr Leu Val Arg His Gln Arg Val
             180                 185                 190        
 His Thr Gly Met Lys Pro Tyr Glu Cys Asn Ala Cys Gly Lys Ala Phe
         195                 200                 205            
 Ser Gln Ser Ser Thr Leu Ile Arg His Tyr Leu Ile His Thr Gly Glu
     210                 215                 220                
 Lys Pro Tyr Lys Cys Leu Glu Cys Gly Lys Ala Phe Lys Arg Arg Ser
 225                 230                 235                 240
 Tyr Leu Met Gln His His Pro Ile His Thr Gly Glu Lys Pro Tyr Glu
                 245                 250                 255    
 Cys Ser Gln Cys Arg Lys Ala Phe Thr His Arg Ser Thr Phe Ile Arg
             260                 265                 270        
 His Asn Arg Thr His Thr Gly Glu Lys Pro Phe Glu Cys Lys Glu Cys
         275                 280                 285            
 Glu Lys Ala Phe Ser Asn Arg Ala His Leu Ile Gln His Tyr Ile Ile
     290                 295                 300                
 His Thr Gly Glu Lys Pro Tyr Asp Cys Met Ala Cys Gly Lys Ala Phe
 305                 310                 315                 320
 Arg Cys Ser Ser Glu Leu Ile Gln His Gln Arg Ile His Thr Gly Glu
                 325                 330                 335    
 Lys Pro Tyr Glu Cys Thr Gln Cys Gly Lys Ala Phe His Arg Ser Thr
             340                 345                 350        
 Tyr Leu Ile Gln His Ser Val Ile His Thr Gly Glu Met Pro Tyr Lys
         355                 360                 365            
 Cys Ile Glu Cys Gly Lys Ala Phe Lys Arg Arg Ser His Leu Leu Gln
     370                 375                 380                
 His Gln Arg Val His Thr
 385                 390



      <210> 1108
      <211> 116
      <212> PRT
      <213> Homo sapiens


      <400> 1108
 Met Tyr Ile Leu Ser Ala Gln Ile Pro Ser His Gln Leu Leu Arg Thr
   1               5                  10                  15    
 His Ser Gln Thr Gly Leu Lys Gln Phe Thr Leu Leu Gln Ser Leu Val
              20                  25                  30        
 Met Arg Arg Ala Thr Pro Gln His Phe Thr Gly Asp Tyr Cys Glu His
          35                  40                  45            
 Trp Arg Pro Pro His Pro Val Gly Ser Leu Ser Ala Ala Ala Tyr Leu
      50                  55                  60                
 Leu Pro Pro Asp Phe Gly Glu Phe Ile Gln Val Asn Ile Asn Glu Val
  65                  70                  75                  80
 Glu Ser His Ser Ile Arg Arg Leu Thr Leu Arg Thr Gln Asp Leu Leu
                  85                  90                  95    
 His Gln Asp Ile Gln Glu Asn Leu Asp Ser Ala Lys Glu Pro Asn Ala
             100                 105                 110        
 Cys Phe Cys Glu
         115    



      <210> 1109
      <211> 276
      <212> PRT
      <213> Homo sapiens


      <400> 1109
 Met Lys Asp Phe Leu Glu Lys Arg Asp Lys Gly Lys Leu Leu Ile Gln
   1               5                  10                  15    
 Arg Ser Arg Arg Leu Lys Gln Asn Leu Leu Arg Pro Met Gln Leu Ser
              20                  25                  30        
 Val Thr Glu Asp Gly Tyr Ile His Tyr Gly Asp Lys Val Met Leu Val
          35                  40                  45            
 Asn Pro Asp Asp Pro Asp Thr Glu Ala Asp Val Phe Leu Arg Gly Asp
      50                  55                  60                
 Leu Ser Leu Cys Met Thr Pro Asp Glu Ile Gln Ser His Leu Lys Asp
  65                  70                  75                  80
 Glu Leu Glu Val Pro Cys Gly Leu Ser Ala Val Gln Ala Lys Thr Pro
                  85                  90                  95    
 Ile Gly Arg Asn Thr Phe Ile Ile Leu Ser Val His Arg Asp Ala Thr
             100                 105                 110        
 Gly Gln Val Leu Arg Tyr Gly Gln Asp Phe Cys Leu Gly Ile Thr Gly
         115                 120                 125            
 Gly Phe Asp Asn Lys Met Leu Tyr Leu Ser Ser Asp His Arg Thr Leu
     130                 135                 140                
 Leu Lys Ser Ser Lys Arg Ser Trp Leu Gln Glu Val Tyr Leu Thr Asp
 145                 150                 155                 160
 Glu Val Ser His Val Asn Cys Trp Gln Ala Ala Phe Pro Asp Pro Gln
                 165                 170                 175    
 Leu Arg Leu Glu Tyr Glu Gly Phe Pro Val Pro Ala Asn Ala Lys Ile
             180                 185                 190        
 Leu Ile Asn His Cys His Thr Asn Arg Gly Leu Ala Ala His Arg His
         195                 200                 205            
 Leu Phe Leu Ser Thr Tyr Phe Gly Lys Glu Ala Glu Val Val Ala His
     210                 215                 220                
 Thr Tyr Leu Asp Ser His Arg Val Glu Lys Pro Arg Asn His Trp Met
 225                 230                 235                 240
 Leu Val Thr Gly Asn Pro Arg Asp Ala Ser Ser Ser Met Leu Asp Leu
                 245                 250                 255    
 Pro Lys Pro Pro Thr Glu Asp Thr Arg Ala Met Glu Gln Ala Met Gly
             260                 265                 270        
 Leu Asp Thr Gln
         275    



      <210> 1110
      <211> 302
      <212> PRT
      <213> Homo sapiens


      <400> 1110
 Met Lys Ser Ala Asn Ile Cys Ile Gly Arg Pro Val Leu Leu Thr Ser
   1               5                  10                  15    
 Leu Asn Gly Lys Gln Glu Val Tyr Thr Ala Trp Pro Met Ala Gly Phe
              20                  25                  30        
 Pro Gly Gly Lys Val Gly Leu Ser Glu Met Ala Gln Lys Asn Val Gly
          35                  40                  45            
 Val Arg Pro Gly Asp Ala Ile Gln Val Gln Pro Leu Val Gly Ala Val
      50                  55                  60                
 Leu Gln Ala Glu Glu Met Asp Val Ala Leu Ser Asp Lys Asp Met Glu
  65                  70                  75                  80
 Ile Asn Glu Glu Glu Leu Thr Gly Cys Ile Leu Arg Lys Leu Asp Gly
                  85                  90                  95    
 Lys Ile Val Leu Pro Gly Asn Phe Leu Tyr Cys Thr Phe Tyr Gly Arg
             100                 105                 110        
 Pro Tyr Lys Leu Gln Val Leu Arg Val Lys Gly Ala Asp Gly Met Ile
         115                 120                 125            
 Leu Gly Gly Pro Gln Ser Asp Ser Asp Thr Asp Ala Gln Arg Met Ala
     130                 135                 140                
 Phe Glu Gln Ser Ser Met Glu Thr Ser Ser Leu Glu Leu Ser Leu Gln
 145                 150                 155                 160
 Leu Ser Gln Leu Asp Leu Glu Asp Thr Gln Ile Pro Thr Ser Arg Ser
                 165                 170                 175    
 Thr Pro Tyr Lys Pro Ile Asp Asp Arg Ile Thr Asn Lys Ala Ser Asp
             180                 185                 190        
 Val Leu Leu Asp Val Thr Gln Ser Pro Gly Asp Gly Ser Gly Leu Met
         195                 200                 205            
 Leu Glu Glu Val Thr Gly Leu Lys Cys Asn Phe Glu Ser Ala Arg Glu
     210                 215                 220                
 Gly Asn Glu Gln Leu Thr Glu Glu Glu Arg Leu Leu Lys Phe Ser Ile
 225                 230                 235                 240
 Gly Ala Lys Cys Asn Thr Asp Thr Phe Tyr Phe Ile Ser Ser Thr Thr
                 245                 250                 255    
 Arg Val Asn Phe Thr Glu Ile Asp Lys Asn Ser Lys Glu Gln Asp Asn
             260                 265                 270        
 Gln Phe Lys Val Thr Tyr Asp Met Ile Gly Gly Leu Ser Ser Gln Leu
         275                 280                 285            
 Lys Ala Ile Arg Glu Ile Ile Glu Leu Pro Leu Lys Thr Ala
     290                 295                 300        



      <210> 1111
      <211> 362
      <212> PRT
      <213> Homo sapiens


      <400> 1111
 Met Lys Tyr Leu Thr Val Gly Asp Leu Glu Asp Cys Leu Leu Asn Lys
   1               5                  10                  15    
 Val Asp Leu Arg Arg Gln Gln Ile Ser Gln Ala Val Glu Glu Val Gln
              20                  25                  30        
 Lys Val Val His His Leu Thr Thr Asn Ile Ser Asn Gln Asp Ile Arg
          35                  40                  45            
 Phe Gln Ala Val Pro Tyr Ser Asp Thr Tyr Asn Glu Asn Ile Lys Val
      50                  55                  60                
 Leu Ala Pro Ser Gln Phe Leu Val Thr Val Pro Ile Lys Gly Leu Ala
  65                  70                  75                  80
 Gly Tyr Arg Glu Ala Arg Glu Gln His Trp Arg Tyr Tyr Thr Leu Gln
                  85                  90                  95    
 Gly Thr Arg Leu Pro Cys Pro Leu Arg Asp Pro Glu Gly Leu Gln Gln
             100                 105                 110        
 Trp Leu Glu Val Glu Gln Phe Met Lys Ser Leu Trp Gln Trp His Glu
         115                 120                 125            
 Thr Asp Val Asn Ile Asp Gly Asp Ile Val Pro Ala Lys Val Leu Leu
     130                 135                 140                
 Val Phe Arg Lys Leu Val Glu Asn Ala Val Arg Thr Cys His Leu Ser
 145                 150                 155                 160
 Gly Lys Val Ser Leu Leu Gly Asn Arg Ser Ala Val Trp Val Ala Val
                 165                 170                 175    
 Glu Thr Ser Ala Tyr Gln Val Glu Leu Glu Leu Val Pro Ala Val Glu
             180                 185                 190        
 Ile Pro Thr Thr Trp Ser Lys Lys Ala Arg Trp Pro Arg Cys Leu Gln
         195                 200                 205            
 Arg Trp Pro Ser Gln Glu Arg Val Glu Cys Ile Lys Ser Phe Gly Phe
     210                 215                 220                
 Asn Leu Leu Ala Cys Ser Asn Tyr His Trp Gln Leu Ser Phe Leu Arg
 225                 230                 235                 240
 Ala Glu Gln Val Leu Leu Glu Gln Leu Asp Glu Asp Gly Gly Cys Arg
                 245                 250                 255    
 Arg Lys Cys Phe Gln Val Met Arg His Leu Lys Glu Asp Ile Trp Cys
             260                 265                 270        
 Pro Gly Asn Arg Pro Val Ile Thr Ser His His Leu Gln Thr Val Leu
         275                 280                 285            
 Phe Trp Thr Cys Glu Lys Tyr Pro His Phe Lys Asp Trp Gln Val Phe
     290                 295                 300                
 Ser Lys Ala Phe Leu Arg Leu Val Arg Lys Leu His Lys Cys Val Ser
 305                 310                 315                 320
 Gln His Phe Leu Lys His Tyr Phe Val Arg Asn Ser Asn Leu Phe Gln
                 325                 330                 335    
 Cys Thr Asn Pro Thr Glu Leu Asp Thr Val Ala Gln Lys Leu Ala Thr
             340                 345                 350        
 Phe Leu Lys Asn Pro Gln Ile Gly Pro Pro
         355                 360        



      <210> 1112
      <211> 465
      <212> PRT
      <213> Homo sapiens


      <400> 1112
 Met Phe Gln Gly Thr Arg Thr Glu Arg Ser Thr Glu Thr Met Glu Leu
   1               5                  10                  15    
 Trp Gly Thr Ala Lys Lys Gly Leu Leu Thr Asp Leu Lys Glu Ala Ser
              20                  25                  30        
 Cys Ser Met Thr Ser Phe His Pro Arg Gly Leu Gln Ala Ala Arg Ala
          35                  40                  45            
 Gln Lys Phe Lys Ser Lys Arg Pro Arg Ser Asn Ser Asp Cys Phe Gln
      50                  55                  60                
 Glu Glu Asp Leu Arg Gln Gly Phe Gln Trp Arg Lys Ser Leu Pro Phe
  65                  70                  75                  80
 Gly Ala Ala Ser Ser Tyr Leu Asn Leu Glu Lys Leu Gly Glu Gly Ser
                  85                  90                  95    
 Tyr Ala Thr Val Tyr Lys Gly Ile Ser Arg Ile Asn Gly Gln Leu Val
             100                 105                 110        
 Ala Leu Lys Val Ile Ser Met Asn Ala Glu Glu Gly Val Pro Phe Thr
         115                 120                 125            
 Ala Ile Arg Glu Ala Ser Leu Leu Lys Gly Leu Lys His Ala Asn Ile
     130                 135                 140                
 Val Leu Leu His Asp Ile Ile His Thr Lys Glu Thr Leu Thr Phe Val
 145                 150                 155                 160
 Phe Glu Tyr Met His Thr Asp Leu Ala Gln Tyr Met Ser Gln His Pro
                 165                 170                 175    
 Gly Gly Leu His Pro His Asn Val Arg Leu Phe Met Phe Gln Leu Leu
             180                 185                 190        
 Arg Gly Leu Ala Tyr Ile His His Gln His Val Leu His Arg Asp Leu
         195                 200                 205            
 Lys Pro Gln Asn Leu Leu Ile Ser His Leu Gly Glu Leu Lys Leu Ala
     210                 215                 220                
 Asp Phe Gly Leu Ala Arg Ala Lys Ser Ile Pro Ser Gln Thr Tyr Ser
 225                 230                 235                 240
 Ser Glu Val Val Thr Leu Trp Tyr Arg Pro Pro Asp Ala Leu Leu Gly
                 245                 250                 255    
 Ala Thr Glu Tyr Ser Ser Glu Leu Asp Ile Trp Gly Ala Gly Cys Ile
             260                 265                 270        
 Phe Ile Glu Met Phe Gln Gly Gln Pro Leu Phe Pro Gly Val Ser Asn
         275                 280                 285            
 Ile Leu Glu Gln Leu Glu Lys Ile Trp Glu Val Leu Gly Val Pro Thr
     290                 295                 300                
 Glu Asp Thr Trp Pro Gly Val Ser Lys Leu Pro Asn Tyr Asn Pro Glu
 305                 310                 315                 320
 Trp Phe Pro Leu Pro Thr Pro Arg Ser Leu His Val Val Trp Asn Arg
                 325                 330                 335    
 Leu Gly Arg Val Pro Glu Ala Glu Asp Leu Ala Ser Gln Met Leu Lys
             340                 345                 350        
 Gly Phe Pro Arg Asp Arg Val Ser Ala Gln Glu Ala Leu Val His Asp
         355                 360                 365            
 Tyr Phe Ser Ala Leu Pro Ser Gln Leu Tyr Gln Leu Pro Asp Gly Glu
     370                 375                 380                
 Arg Gly Ser Val Cys Val Cys Val Ser Ala Cys Ala Thr Gly Gly Glu
 385                 390                 395                 400
 Arg Leu Gln Gly Pro Leu Cys Asn Gly Pro Asp Ile Ser Gln Val His
                 405                 410                 415    
 Ile Tyr Thr Gln Lys Leu Asp Glu Met Asp Val Val Ser Glu Leu Phe
             420                 425                 430        
 Ala Leu Ala Thr Ile Cys Gln Glu Ala Thr Pro Val Phe Leu Thr Arg
         435                 440                 445            
 Leu Phe Ser Leu Ser Ala Glu Ser Lys Met Ile Gly Glu Ala Asp Met
     450                 455                 460                
 Ser
 465



      <210> 1113
      <211> 535
      <212> PRT
      <213> Homo sapiens


      <400> 1113
 Met Asp Pro Ser Pro Met Thr Val Met Cys Leu Gly Ser His Glu Ala
   1               5                  10                  15    
 Lys Ser Ser Ser Thr Gly Glu Arg Pro Leu Trp Gly Leu Thr Phe Cys
              20                  25                  30        
 Val Phe Ile His Lys Tyr Glu Tyr Ile Leu His Asp Ile Arg Leu Gln
          35                  40                  45            
 Phe Ile Leu Ile Asn Met Lys Gly Pro Asn Glu Tyr Leu Leu Gly Ser
      50                  55                  60                
 Ser Cys Val Leu Asp Thr Phe Thr Asn Val Leu Arg Lys Leu Leu Thr
  65                  70                  75                  80
 Gln Pro Gln Gln Ala Lys Ala Asp Val Leu Ser Leu Glu Glu Ile Leu
                  85                  90                  95    
 Ala Glu Gly Val Glu Glu Ser Asp Ala Ser Ser Gln Gly Ser Gly Ser
             100                 105                 110        
 Glu Gly Pro Val Arg Leu Ser Arg Thr Arg Thr Lys Ala Leu Gln Glu
         115                 120                 125            
 Ala Met Tyr Tyr Ser Ala Glu His Gly Tyr Val Asp Ile Thr Met Glu
     130                 135                 140                
 Leu Arg Ala Leu Gly Val Pro Trp Lys Leu His Ile Trp Ile Glu Ser
 145                 150                 155                 160
 Leu Arg Thr Ser Phe Ser Gln Ser Arg Tyr Ser Val Val Gln Ser Leu
                 165                 170                 175    
 Leu Arg Asp Phe Ser Ser Ile Arg Glu Glu Glu Tyr Asn Glu Glu Leu
             180                 185                 190        
 Val Thr Glu Gly Leu Gln Leu Met Phe Asp Ile Leu Lys Thr Ser Lys
         195                 200                 205            
 Asn Asp Ser Val Ile Gln Gln Leu Ala Thr Ile Phe Thr His Cys Tyr
     210                 215                 220                
 Gly Ser Ser Pro Ile Pro Ser Ile Pro Glu Ile Arg Lys Thr Leu Pro
 225                 230                 235                 240
 Ala Arg Leu Asp Pro His Phe Leu Asn Asn Lys Glu Met Ser Asp Val
                 245                 250                 255    
 Thr Phe Leu Val Glu Gly Lys Leu Phe Tyr Ala His Lys Val Leu Leu
             260                 265                 270        
 Val Thr Ala Ser Asn Arg Phe Lys Thr Leu Met Thr Asn Lys Ser Glu
         275                 280                 285            
 Gln Asp Gly Asp Ser Ser Lys Thr Ile Glu Ile Ser Asp Met Lys Tyr
     290                 295                 300                
 His Ile Phe Gln Met Met Met Gln Tyr Leu Tyr Tyr Gly Gly Thr Glu
 305                 310                 315                 320
 Ser Met Glu Ile Pro Thr Ala Asp Ile Leu Glu Leu Leu Ser Ala Ala
                 325                 330                 335    
 Ser Leu Phe Gln Leu Asp Ala Leu Gln Arg His Cys Glu Ile Leu Cys
             340                 345                 350        
 Ser Gln Thr Leu Ser Met Glu Ser Ala Val Asn Thr Tyr Lys Tyr Ala
         355                 360                 365            
 Lys Ile His Asn Ala Pro Glu Leu Ala Leu Phe Cys Glu Gly Phe Phe
     370                 375                 380                
 Leu Lys His Met Lys Ala Leu Leu Glu Gln Asp Ala Phe Arg Gln Leu
 385                 390                 395                 400
 Ile Tyr Gly Arg Ser Ser Lys Val Gln Gly Leu Asp Pro Leu Gln Asp
                 405                 410                 415    
 Leu Gln Asn Thr Leu Ala Glu Arg Val His Ser Val Tyr Ile Thr Ser
             420                 425                 430        
 Arg Val Leu Leu Gly Trp Glu Ala Leu Asp Thr Leu Leu Thr Phe Asp
         435                 440                 445            
 Leu Asp Thr Asn Thr Phe Gln Ile Pro Pro Gly Ser Gln Asp Pro Pro
     450                 455                 460                
 Glu Glu Thr Ser Ser Lys His Ala Pro Arg Pro Phe Val Pro Val Lys
 465                 470                 475                 480
 Ala Thr Val Leu Lys Ala Lys Ala Ile Met Gly Pro Val Leu His Leu
                 485                 490                 495    
 Pro Tyr Cys Thr Lys Gln Arg Gln Val Thr Leu Thr Val Gly Phe Cys
             500                 505                 510        
 Ala Ala Pro Gln Ser Ile Trp Glu Met Arg Pro Ala Ser Met Leu Asp
         515                 520                 525            
 Pro Ser Arg Cys His Ser Asp
     530                 535



      <210> 1114
      <211> 460
      <212> PRT
      <213> Homo sapiens


      <400> 1114
 Met Ile Ile Ser Arg Lys Lys Glu Lys Glu Gly Arg Arg Thr Ala Gln
   1               5                  10                  15    
 Leu Thr Ala Val Leu Arg Lys Ile Leu Asp Pro Arg Leu Ile Ser Thr
              20                  25                  30        
 Glu Glu Asn Thr Gln Gly Ala Glu Thr Met Gly Pro Leu Ser Ala Pro
          35                  40                  45            
 Pro Cys Thr Gln His Ile Thr Trp Lys Gly Leu Leu Leu Thr Ala Ser
      50                  55                  60                
 Leu Leu Asn Phe Trp Asn Pro Pro Thr Thr Ala Gln Val Thr Ile Glu
  65                  70                  75                  80
 Ala Gln Pro Pro Lys Val Ser Glu Gly Lys Asp Val Leu Leu Leu Val
                  85                  90                  95    
 His Asn Leu Pro Gln Asn Leu Thr Gly Tyr Ile Trp Tyr Lys Gly Gln
             100                 105                 110        
 Ile Arg Asp Leu Tyr His Tyr Val Thr Ser Tyr Val Val Asp Gly Gln
         115                 120                 125            
 Ile Ile Lys Tyr Gly Pro Ala Tyr Ser Gly Arg Glu Thr Val Tyr Ser
     130                 135                 140                
 Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln Glu Asp Thr Gly Ser
 145                 150                 155                 160
 Tyr Thr Leu His Ile Ile Lys Arg Gly Asp Gly Thr Gly Gly Val Thr
                 165                 170                 175    
 Gly Arg Phe Thr Phe Thr Leu Tyr Leu Glu Thr Pro Lys Pro Ser Ile
             180                 185                 190        
 Ser Ser Ser Asn Phe Asn Pro Arg Glu Ala Thr Glu Ala Val Ile Leu
         195                 200                 205            
 Thr Cys Asp Pro Glu Thr Pro Asp Ala Ser Tyr Leu Trp Trp Met Asn
     210                 215                 220                
 Gly Gln Ser Leu Pro Met Thr His Ser Leu Gln Leu Ser Glu Thr Asn
 225                 230                 235                 240
 Arg Thr Leu Tyr Leu Phe Gly Val Thr Asn Tyr Thr Ala Gly Pro Tyr
                 245                 250                 255    
 Glu Cys Glu Ile Arg Asn Pro Val Ser Ala Ser Arg Ser Asp Pro Val
             260                 265                 270        
 Thr Leu Asn Leu Leu Pro Lys Leu Pro Lys Pro Tyr Ile Thr Ile Asn
         275                 280                 285            
 Asn Leu Asn Pro Arg Glu Asn Lys Asp Val Ser Thr Phe Thr Cys Glu
     290                 295                 300                
 Pro Lys Ser Glu Asn Tyr Thr Tyr Ile Trp Trp Leu Asn Gly Gln Ser
 305                 310                 315                 320
 Leu Pro Val Ser Pro Arg Val Lys Arg Arg Ile Glu Asn Arg Ile Leu
                 325                 330                 335    
 Ile Leu Pro Ser Val Thr Arg Asn Glu Thr Gly Pro Tyr Gln Cys Glu
             340                 345                 350        
 Ile Arg Asp Arg Tyr Gly Gly Ile Arg Ser Asp Pro Val Thr Leu Asn
         355                 360                 365            
 Val Leu Tyr Gly Pro Asp Leu Pro Arg Ile Tyr Pro Ser Phe Thr Tyr
     370                 375                 380                
 Tyr His Ser Gly Gln Asn Leu Tyr Leu Ser Cys Phe Ala Asp Ser Asn
 385                 390                 395                 400
 Pro Pro Ala Gln Tyr Ser Trp Thr Ile Asn Gly Lys Phe Gln Leu Ser
                 405                 410                 415    
 Gly Gln Lys Leu Ser Ile Pro Gln Ile Thr Thr Lys His Ser Gly Leu
             420                 425                 430        
 Tyr Ala Cys Ser Val Arg Asn Ser Ala Thr Gly Lys Glu Ser Ser Lys
         435                 440                 445            
 Ser Val Thr Val Arg Val Ser Asp Trp Thr Leu Pro
     450                 455                 460



      <210> 1115
      <211> 373
      <212> PRT
      <213> Homo sapiens


      <400> 1115
 Met Ile Ile Ser Arg Lys Lys Glu Lys Glu Gly Arg Arg Thr Ala Gln
   1               5                  10                  15    
 Leu Thr Ala Val Leu Trp Lys Leu Leu Asp Pro Arg Leu Ile Ser Thr
              20                  25                  30        
 Glu Glu Asn Met His Ala Ala Glu Ile Met Gly Pro Leu Ser Ala Pro
          35                  40                  45            
 Pro Cys Thr Glu His Ile Lys Trp Lys Gly Leu Leu Leu Thr Ala Leu
      50                  55                  60                
 Leu Leu Asn Phe Trp Asn Leu Pro Thr Thr Ala Gln Val Met Ile Glu
  65                  70                  75                  80
 Ala Gln Pro Pro Lys Val Ser Glu Gly Lys Asp Val Leu Leu Leu Val
                  85                  90                  95    
 His Asn Leu Pro Gln Asn Leu Thr Gly Tyr Ile Trp Tyr Lys Gly Gln
             100                 105                 110        
 Ile Arg Asp Leu Tyr His Tyr Ile Thr Ser Tyr Val Val Asp Gly Gln
         115                 120                 125            
 Ile Ile Ile Tyr Gly Pro Ala Tyr Ser Gly Arg Glu Thr Val Tyr Ser
     130                 135                 140                
 Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Arg Glu Asp Ala Gly Ser
 145                 150                 155                 160
 Tyr Thr Leu His Ile Ile Lys Arg Gly Asp Gly Thr Arg Gly Val Thr
                 165                 170                 175    
 Gly Tyr Phe Thr Phe Thr Leu Tyr Leu Glu Thr Pro Lys Pro Ser Ile
             180                 185                 190        
 Ser Ser Ser Asn Leu Asn Pro Arg Glu Ala Met Glu Thr Val Ile Leu
         195                 200                 205            
 Thr Cys Asn Pro Glu Thr Pro Asp Ala Ser Tyr Leu Trp Trp Met Asn
     210                 215                 220                
 Gly Gln Ser Leu Pro Met Thr His Arg Met Gln Leu Ser Glu Thr Asn
 225                 230                 235                 240
 Arg Thr Leu Phe Leu Phe Gly Val Thr Lys Tyr Thr Ala Gly Pro Tyr
                 245                 250                 255    
 Glu Cys Glu Ile Trp Asn Ser Gly Ser Ala Ser Arg Ser Asp Pro Val
             260                 265                 270        
 Thr Leu Asn Leu Leu His Gly Pro Asp Leu Pro Arg Ile Phe Pro Ser
         275                 280                 285            
 Val Thr Ser Tyr Tyr Ser Gly Glu Asn Leu Asp Leu Ser Cys Phe Ala
     290                 295                 300                
 Asp Ser Asn Pro Pro Ala Gln Tyr Ser Trp Thr Ile Asn Gly Lys Phe
 305                 310                 315                 320
 Gln Leu Ser Gly Gln Lys Leu Phe Ile Pro Gln Ile Thr Pro Lys His
                 325                 330                 335    
 Asn Gly Leu Tyr Ala Cys Ser Ala Arg Asn Ser Ala Thr Gly Glu Glu
             340                 345                 350        
 Ser Ser Thr Ser Leu Thr Ile Arg Val Ile Ala Pro Pro Gly Leu Gly
         355                 360                 365            
 Thr Phe Cys Phe Gln
     370            



      <210> 1116
      <211> 169
      <212> PRT
      <213> Homo sapiens


      <400> 1116
 Met Leu Leu Ser Leu Phe Cys Phe Asp Gly Thr Ala Gly Asp Ser Lys
   1               5                  10                  15    
 Ala Leu Lys Glu Ala Ser Lys Glu Ser Asp His Val Val Thr Val Ile
              20                  25                  30        
 Asp Ala His Thr Ala Glu Ala Ile Thr Cys Glu Lys Ala Leu Ser Ser
          35                  40                  45            
 Leu Ser Ala Gly Thr Ala Ala Pro Gly Ser Ile Ser Asp Arg Asp Arg
      50                  55                  60                
 Ala Met Ala Thr Ser Arg Ser Ser Asp Gly Ala Ser Ser Thr Phe Arg
  65                  70                  75                  80
 Leu Phe Arg Gly Ser Phe Leu Leu Ala Ile Ile Met Cys Arg Cys Ser
                  85                  90                  95    
 Tyr Pro Cys Lys Leu Leu Leu Gln Gly Gln Gly His Arg Ser Val Ala
             100                 105                 110        
 Leu Trp Gly Arg Gly Pro Lys Pro Ile His Cys Gly Glu Ala Pro Lys
         115                 120                 125            
 Ile Arg Glu Asn Lys Leu Gln Arg Gln Ala His Pro Gln Thr Ser Ala
     130                 135                 140                
 Leu Ser Ala Pro Ala Asp His Gly Glu Gln Val Glu Arg Lys Glu Thr
 145                 150                 155                 160
 Arg Thr Gln Leu His Ser Ala Gly Trp
                 165                



      <210> 1117
      <211> 101
      <212> PRT
      <213> Homo sapiens


      <400> 1117
 Met Ile Asp Met Asp Asn Thr Val Met Leu Ser Gly Leu Glu Lys Trp
   1               5                  10                  15    
 Asn Ala Lys Arg Glu Arg Thr Asn Lys Gln Glu Glu Gln Arg Thr Asp
              20                  25                  30        
 Glu Ile Asn Asn Lys Gln Val Leu Lys Thr Leu Ser Ser Glu Gly Tyr
          35                  40                  45            
 Thr Gly Ser Phe Tyr Gln Met Phe Leu Lys Glu Leu Ile Leu Ile Leu
      50                  55                  60                
 Pro Arg Leu Phe Gln Lys Thr Glu Glu Arg Lys Thr Pro Leu Asn Ser
  65                  70                  75                  80
 Ser Tyr Glu Ala Lys Asn Ile Arg Ile Pro Lys Pro Asp Glu Asp Ile
                  85                  90                  95    
 Thr Arg Lys Thr Tyr
             100    



      <210> 1118
      <211> 242
      <212> PRT
      <213> Homo sapiens


      <400> 1118
 Met Ser Asp Lys Leu Lys Glu Arg Lys Arg Thr Pro Val Ser His Lys
   1               5                  10                  15    
 Val Ile Glu Lys Arg Arg Arg Asp Arg Ile Asn Arg Cys Leu Asn Glu
              20                  25                  30        
 Leu Gly Lys Thr Val Pro Met Ala Leu Ala Lys Gln Ser Ser Gly Lys
          35                  40                  45            
 Leu Glu Lys Ala Glu Ile Leu Glu Met Thr Val Gln Tyr Leu Arg Ala
      50                  55                  60                
 Leu His Ser Ala Asp Phe Pro Arg Gly Arg Glu Lys Ala Glu Leu Leu
  65                  70                  75                  80
 Ala Glu Phe Ala Asn Tyr Phe His Tyr Gly Tyr His Glu Cys Met Lys
                  85                  90                  95    
 Asn Leu Val His Tyr Leu Thr Thr Val Glu Arg Met Glu Thr Lys Asp
             100                 105                 110        
 Thr Lys Tyr Ala Arg Ile Leu Ala Phe Leu Gln Ser Lys Ala Arg Leu
         115                 120                 125            
 Gly Ala Glu Pro Ala Phe Pro Pro Leu Gly Ser Leu Pro Glu Pro Asp
     130                 135                 140                
 Phe Ser Tyr Gln Leu His Pro Ala Gly Pro Glu Phe Ala Gly His Ser
 145                 150                 155                 160
 Pro Gly Glu Ala Ala Val Phe Pro Gln Gly Ser Gly Ala Gly Pro Phe
                 165                 170                 175    
 Pro Trp Pro Pro Gly Ala Ala Arg Ser Pro Ala Leu Pro Tyr Leu Pro
             180                 185                 190        
 Ser Ala Pro Val Pro Leu Ala Ser Pro Ala Gln Gln His Ser Pro Phe
         195                 200                 205            
 Leu Thr Pro Val Gln Gly Leu Asp Arg His Tyr Leu Asn Leu Ile Gly
     210                 215                 220                
 His Ala His Pro Asn Ala Leu Asn Leu His Thr Pro Gln His Pro Pro
 225                 230                 235                 240
 Val Leu
        



      <210> 1119
      <211> 279
      <212> PRT
      <213> Homo sapiens


      <400> 1119
 Met Ser Asp Lys Leu Lys Glu Arg Lys Arg Thr Pro Val Ser His Lys
   1               5                  10                  15    
 Val Ile Glu Lys Arg Arg Arg Asp Arg Ile Asn Arg Cys Leu Asn Glu
              20                  25                  30        
 Leu Gly Lys Thr Val Pro Met Ala Leu Ala Lys Gln Glu Ala Leu Ala
          35                  40                  45            
 Gln Ile Arg Ser Arg Val Arg Ser Leu Val Leu Ser Ser Ala Thr Val
      50                  55                  60                
 Pro Asp Gln Gln Ala Leu Gly Arg Cys Glu Gly Pro Phe Leu Leu Leu
  65                  70                  75                  80
 Gln Ser Ser Gly Lys Leu Glu Lys Ala Glu Ile Leu Glu Met Thr Val
                  85                  90                  95    
 Gln Tyr Leu Arg Ala Leu His Ser Ala Asp Phe Pro Arg Gly Arg Glu
             100                 105                 110        
 Lys Ala Glu Leu Leu Ala Glu Phe Ala Asn Tyr Phe His Tyr Gly Tyr
         115                 120                 125            
 His Glu Cys Met Lys Asn Leu Val His Tyr Leu Thr Thr Val Glu Arg
     130                 135                 140                
 Met Glu Thr Lys Asp Thr Lys Tyr Ala Arg Ile Leu Ala Phe Leu Gln
 145                 150                 155                 160
 Ser Lys Ala Arg Leu Gly Ala Glu Pro Ala Phe Pro Pro Leu Gly Ser
                 165                 170                 175    
 Leu Pro Glu Pro Asp Phe Ser Tyr Gln Leu His Pro Ala Gly Pro Glu
             180                 185                 190        
 Phe Ala Gly His Ser Pro Gly Glu Ala Ala Val Phe Pro Gln Gly Ser
         195                 200                 205            
 Gly Ala Gly Pro Phe Pro Trp Pro Pro Gly Ala Ala Arg Ser Pro Ala
     210                 215                 220                
 Leu Pro Tyr Leu Pro Ser Ala Pro Val Pro Leu Ala Ser Pro Ala Gln
 225                 230                 235                 240
 Gln His Ser Pro Phe Leu Thr Pro Val Gln Gly Leu Asp Arg His Tyr
                 245                 250                 255    
 Leu Asn Leu Ile Gly His Ala His Pro Asn Ala Leu Asn Leu His Thr
             260                 265                 270        
 Pro Gln His Pro Pro Val Leu
         275                



      <210> 1120
      <211> 151
      <212> PRT
      <213> Homo sapiens


      <400> 1120
 Met Ala His Ser Trp Lys Leu Val Ala Leu Ser Arg Cys Gln Gly Trp
   1               5                  10                  15    
 Gln Thr Phe Lys Met Ala Ser Ala Ala Val Pro Asn His Leu Pro Leu
              20                  25                  30        
 Ile Gln Thr Phe Tyr Pro Ile Ile Ser Pro Met Arg Pro Lys Ala Glu
          35                  40                  45            
 Asn Thr Cys Tyr Ile Tyr Asn Lys Glu Asn Asp Ser Leu Lys Thr Glu
      50                  55                  60                
 Thr Gln Thr Met His Gln Lys Pro Met Thr Asp Asn Ala Arg Gln Met
  65                  70                  75                  80
 Ser Arg Asp Thr Pro Val Pro Ile Asn Phe Thr Asp Gln Gln Thr Thr
                  85                  90                  95    
 Asp Asn Pro Asp Asp Val Lys Glu Lys Lys His Pro Glu Asn Asn Gln
             100                 105                 110        
 Lys Ser Glu Asn Asn Gln Lys Leu Leu Thr Gly Ala Asn Ser Ser Arg
         115                 120                 125            
 Phe Leu Asp Gly Asn Val Ala Cys Ser Leu Gly Lys Leu Phe Leu Thr
     130                 135                 140                
 Ser Met Ile Trp Ile Ile Cys
 145                 150    



      <210> 1121
      <211> 212
      <212> PRT
      <213> Homo sapiens


      <400> 1121
 Met Glu Asp Leu Phe Ser Cys Phe Phe Asn Phe Thr Ser Pro Ser Gly
   1               5                  10                  15    
 Val Val Leu Ser Pro Asn Tyr Pro Glu Asp Tyr Gly Asn His Leu His
              20                  25                  30        
 Cys Val Trp Leu Ile Leu Ala Arg Pro Glu Ser Arg Ile His Leu Ala
          35                  40                  45            
 Phe Asn Asp Ile Asp Val Glu Pro Gln Phe Asp Phe Leu Val Ile Lys
      50                  55                  60                
 Asp Gly Ala Thr Ala Glu Ala Pro Val Leu Gly Thr Phe Ser Gly Asn
  65                  70                  75                  80
 Gln Leu Pro Ser Ser Ile Thr Ser Ser Gly His Val Ala Arg Leu Glu
                  85                  90                  95    
 Phe Gln Thr Asp His Ser Thr Gly Lys Arg Gly Phe Asn Ile Thr Phe
             100                 105                 110        
 Thr Thr Gly Pro Pro Ser Glu Cys Leu Pro Leu Arg Met Ile Glu Gly
         115                 120                 125            
 Ala Pro Met Glu Gly Gly Gly Ala Phe Arg His Asn Glu Cys Pro Asp
     130                 135                 140                
 Pro Gly Val Pro Val Asn Gly Lys Arg Phe Gly Asp Ser Leu Gln Leu
 145                 150                 155                 160
 Gly Ser Ser Ile Ser Phe Leu Cys Asp Glu Gly Phe Leu Gly Thr Gln
                 165                 170                 175    
 Gly Ser Glu Thr Ile Thr Cys Val Leu Lys Glu Gly Ser Val Val Trp
             180                 185                 190        
 Asn Ser Ala Val Leu Arg Cys Glu Ala Ala Leu Asp Asn Thr Glu Val
         195                 200                 205            
 Asn Gly Leu Asp
     210        



      <210> 1122
      <211> 798
      <212> PRT
      <213> Homo sapiens


      <400> 1122
 Met Gln Thr Gln Glu Pro Pro Gln Leu Gln Ser Thr Pro Arg Pro Leu
   1               5                  10                  15    
 Gln Glu Glu Val Pro Val Val Arg Pro Leu Gln Pro Arg Ala Ala Arg
              20                  25                  30        
 Gly Gly Ala Gly Gly Gly Ala Gln Ser Gln Gly Val Lys Glu Pro Gly
          35                  40                  45            
 Pro Glu Ala Gly Leu His Thr Ala Pro Leu Gln Glu Arg Arg Ile Gly
      50                  55                  60                
 Gly Val Phe Gln Asp Leu Val Val Asn Thr Arg Gln Asp Met Lys His
  65                  70                  75                  80
 Val Lys Asp Ser Lys Thr Gly Ser Glu Gly Thr Val Val Gln Leu Leu
                  85                  90                  95    
 Ala Asn His Phe Arg Val Ile Ser Arg Pro Gln Trp Val Ala Tyr Lys
             100                 105                 110        
 Tyr Asn Val Asp Tyr Lys Pro Asp Ile Glu Asp Gly Asn Leu Arg Thr
         115                 120                 125            
 Ile Leu Leu Asp Gln His Arg Arg Lys Phe Gly Glu Arg His Ile Phe
     130                 135                 140                
 Asp Gly Asn Ser Leu Leu Leu Ser Arg Pro Leu Lys Glu Arg Arg Val
 145                 150                 155                 160
 Glu Trp Leu Ser Thr Thr Lys Asp Lys Asn Ile Val Lys Ile Thr Val
                 165                 170                 175    
 Glu Phe Ser Lys Glu Leu Thr Pro Thr Ser Pro Asp Cys Leu Arg Tyr
             180                 185                 190        
 Tyr Asn Ile Leu Phe Arg Arg Thr Phe Lys Leu Leu Asp Phe Glu Gln
         195                 200                 205            
 Val Gly Arg Asn Tyr Tyr Thr Lys Lys Lys Ala Ile Gln Leu Tyr Arg
     210                 215                 220                
 His Gly Thr Ser Leu Glu Ile Trp Leu Gly Tyr Val Thr Ser Val Leu
 225                 230                 235                 240
 Gln Tyr Glu Asn Ser Ile Thr Leu Cys Ala Asp Val Ser His Lys Leu
                 245                 250                 255    
 Leu Arg Ile Glu Thr Ala Tyr Asp Phe Ile Lys Arg Thr Ser Ala Gln
             260                 265                 270        
 Ala Gln Thr Gly Asn Ile Arg Glu Glu Val Thr Asn Lys Leu Ile Gly
         275                 280                 285            
 Ser Ile Val Leu Thr Lys Tyr Asn Asn Lys Thr Tyr Arg Val Asp Asp
     290                 295                 300                
 Ile Asp Trp Lys Gln Asn Pro Glu Asp Thr Phe Asn Lys Ser Asp Gly
 305                 310                 315                 320
 Ser Lys Ile Thr Tyr Ile Asp Tyr Tyr Arg Gln Gln His Lys Glu Ile
                 325                 330                 335    
 Val Thr Val Lys Lys Gln Pro Leu Leu Val Ser Gln Gly Arg Trp Lys
             340                 345                 350        
 Lys Gly Leu Thr Gly Thr Gln Arg Glu Pro Ile Leu Leu Ile Pro Gln
         355                 360                 365            
 Leu Cys His Met Thr Gly Thr Asp Gly Leu Gln Pro Leu Phe Lys Val
     370                 375                 380                
 Arg Tyr Asn Tyr Asp Leu Thr Gln Ala Phe Gln Gly Ile Arg Arg Val
 385                 390                 395                 400
 Lys Ala Asn Ser Gln Gly Asp Trp Ser Arg Glu Ile Arg Glu Leu Pro
                 405                 410                 415    
 Leu Leu Asn Ala Met Pro Leu His Ser Trp Leu Ile Leu Tyr Ser Arg
             420                 425                 430        
 Ser Ser His Arg Glu Ala Met Ser Leu Lys Gly His Leu Gln Ser Val
         435                 440                 445            
 Thr Ala Pro Met Gly Ile Thr Met Lys Pro Ala Glu Met Ile Glu Val
     450                 455                 460                
 Asp Gly Asp Ala Asn Ser Tyr Ile Asp Thr Leu Arg Lys Tyr Thr Arg
 465                 470                 475                 480
 Pro Thr Leu Gln Met Gly Met Ser Cys Leu Leu Val Phe Lys Val Ile
                 485                 490                 495    
 Cys Ile Leu Pro Asn Asp Asp Lys Arg Arg Tyr Asp Ser Ile Lys Arg
             500                 505                 510        
 Tyr Leu Cys Thr Lys Cys Pro Ile Pro Ser Gln Cys Val Val Lys Lys
         515                 520                 525            
 Thr Leu Glu Lys Val Gln Ala Arg Thr Ile Val Thr Lys Ile Ala Gln
     530                 535                 540                
 Gln Met Asn Cys Lys Met Gly Gly Ala Leu Trp Lys Val Glu Thr Asn
 545                 550                 555                 560
 Val Gln Arg Thr Met Phe Val Gly Ile Asp Cys Phe His Asp Ile Val
                 565                 570                 575    
 Asn Arg Gln Lys Ser Ile Ala Gly Phe Val Ala Ser Thr Asn Ala Glu
             580                 585                 590        
 Leu Thr Lys Trp Tyr Ser Gln Cys Val Ile Gln Lys Thr Gly Glu Glu
         595                 600                 605            
 Leu Val Lys Glu Leu Glu Ile Cys Leu Lys Ala Ala Leu Asp Val Trp
     610                 615                 620                
 Cys Lys Asn Glu Ser Ser Met Pro His Ser Val Ile Val Tyr Arg Asp
 625                 630                 635                 640
 Gly Val Gly Asp Gly Gln Leu Gln Ala Leu Leu Asp His Glu Ala Lys
                 645                 650                 655    
 Lys Met Ser Thr Tyr Leu Lys Thr Ile Ser Pro Asn Asn Phe Thr Leu
             660                 665                 670        
 Ala Phe Ile Val Val Lys Lys Arg Ile Asn Thr Arg Phe Phe Leu Lys
         675                 680                 685            
 His Gly Ser Asn Phe Gln Asn Pro Pro Pro Gly Thr Val Ile Asp Val
     690                 695                 700                
 Glu Leu Thr Arg Asn Glu Trp Tyr Asp Phe Phe Ile Val Ser Gln Ser
 705                 710                 715                 720
 Val Gln Asp Gly Thr Val Thr Pro Thr His Tyr Asn Val Ile Tyr Asp
                 725                 730                 735    
 Thr Ile Gly Leu Ser Pro Asp Thr Val Gln Arg Leu Thr Tyr Cys Leu
             740                 745                 750        
 Cys His Met Tyr Tyr Asn Leu Pro Gly Ile Ile Arg Val Pro Ala Pro
         755                 760                 765            
 Cys His Tyr Ala His Lys Leu Ala Tyr Leu Val Gly Gln Ser Ile His
     770                 775                 780                
 Gln Glu Pro Asn Arg Ser Leu Ser Thr Arg Leu Phe Tyr Leu
 785                 790                 795            



      <210> 1123
      <211> 314
      <212> PRT
      <213> Homo sapiens


      <400> 1123
 Met Asp Thr Val Arg Lys Asp Leu Pro Pro Thr Pro Ala Leu Thr Gln
   1               5                  10                  15    
 Leu Val Cys Asp Thr Leu Gly Lys Glu Phe Phe Phe Leu Asp Ser Glu
              20                  25                  30        
 Thr Arg Leu Cys Lys Ile Ala Pro Glu Gly Trp Arg Glu Gln Pro Gln
          35                  40                  45            
 Lys Thr Ser Met Asn Thr Phe Thr Leu Phe Leu Arg Ile Lys Phe Phe
      50                  55                  60                
 Val Ser His Tyr Gly Leu Leu Gln His Ser Leu Thr Arg His Gln Phe
  65                  70                  75                  80
 Tyr Leu Gln Leu Arg Lys Asp Ile Leu Glu Glu Arg Leu Tyr Cys Asn
                  85                  90                  95    
 Glu Glu Ile Leu Leu Gln Leu Gly Val Leu Ala Leu Gln Ala Glu Phe
             100                 105                 110        
 Gly Asn Tyr Pro Lys Glu Val Ser Thr Asn Pro Leu Glu Phe Leu Ala
         115                 120                 125            
 Pro Gln Val Asp Pro Leu Asp Thr Phe Ser His Pro Pro Ile Pro Leu
     130                 135                 140                
 Ala Ser Thr Gly Gly Tyr Ser Leu Asn Thr Phe Met Cys Ser Asn Asp
 145                 150                 155                 160
 Ala Lys Ala Lys Thr Ser Leu Ser Pro Pro Ala Ser Val Trp Ile Val
                 165                 170                 175    
 Pro Phe Pro Ser Thr Ser Tyr Phe Gln Gln Val Glu Ser Lys Pro Tyr
             180                 185                 190        
 Phe His Val Glu Asp Tyr Ile Pro Ala Ser Leu Ile Glu Arg Met Thr
         195                 200                 205            
 Ala Leu Arg Val Gln Val Glu Val Ser Glu Met His Arg Leu Ser Ser
     210                 215                 220                
 Ala Leu Trp Gly Glu Asp Ala Glu Leu Lys Phe Leu Arg Val Thr Gln
 225                 230                 235                 240
 Gln Leu Pro Glu Tyr Gly Val Leu Val His Gln Val Phe Ser Glu Lys
                 245                 250                 255    
 Arg Arg Pro Glu Glu Glu Met Ala Leu Gly Ile Cys Ala Lys Gly Val
             260                 265                 270        
 Ile Val Tyr Glu Val Lys Asn Asn Ser Arg Ile Ala Met Leu Arg Phe
         275                 280                 285            
 Gln Trp Arg Glu Thr Gly Lys Ile Ser Thr Tyr Val Ser Val Ala Gln
     290                 295                 300                
 Leu Ile Asn Asn Leu His Phe Ile Phe Leu
 305                 310                



      <210> 1124
      <211> 553
      <212> PRT
      <213> Homo sapiens


      <400> 1124
 Met Asp Val Asp Lys Glu Leu Gly Met Glu Ser Val Lys Ala Gly Ala
   1               5                  10                  15    
 Ser Gly Lys Pro Glu Met Arg Leu Gly Thr Gln Glu Glu Thr Ser Glu
              20                  25                  30        
 Gly Asp Ala Asn Glu Ser Ser Leu Leu Val Leu Ser Ser Asn Val Pro
          35                  40                  45            
 Leu Leu Ala Leu Glu Phe Leu Glu Ile Ala Gln Ala Lys Glu Lys Ala
      50                  55                  60                
 Phe Leu Pro Met Val Ser His Thr Phe His Met Arg Thr Glu Glu Ser
  65                  70                  75                  80
 Asp Ala Ser Gln Glu Gly Asp Asp Leu Pro Lys Ser Ser Ala Asn Thr
                  85                  90                  95    
 Ser His Pro Lys Gln Asp Asp Ser Pro Lys Ser Ser Glu Glu Thr Ile
             100                 105                 110        
 Gln Pro Lys Glu Gly Asp Ile Pro Lys Ala Pro Glu Glu Thr Ile Gln
         115                 120                 125            
 Ser Lys Lys Glu Asp Leu Pro Lys Ser Ser Glu Lys Ala Ile Gln Pro
     130                 135                 140                
 Lys Glu Ser Asn Ile Pro Lys Ser Ser Ala Lys Pro Ile Gln Pro Lys
 145                 150                 155                 160
 Leu Gly Asn Ile Pro Lys Ala Ser Val Lys Pro Ser Gln Pro Lys Glu
                 165                 170                 175    
 Gly Asp Ile Pro Lys Ala Pro Glu Glu Thr Ile Gln Ser Lys Lys Glu
             180                 185                 190        
 Asp Leu Pro Lys Ser Ser Glu Glu Ala Ile Gln Pro Lys Glu Gly Asp
         195                 200                 205            
 Ile Pro Lys Ser Ser Ala Lys Pro Ile Gln Pro Lys Leu Gly Asn Ile
     210                 215                 220                
 Ala Lys Thr Ser Val Lys Pro Ser Gln Pro Lys Glu Ser Asp Ile Pro
 225                 230                 235                 240
 Lys Ser Pro Glu Glu Thr Ile Gln Pro Lys Glu Gly Asp Ile Pro Lys
                 245                 250                 255    
 Ser Ser Ala Lys Pro Ile Gln Pro Lys Leu Gly Asn Ile Pro Lys Ala
             260                 265                 270        
 Ser Val Lys Pro Ser Gln Pro Lys Glu Gly Asp Ile Ser Lys Ser Pro
         275                 280                 285            
 Glu Glu Ala Ile Gln Pro Lys Glu Gly Asp Leu Pro Lys Ser Leu Glu
     290                 295                 300                
 Glu Ala Ile Gln Pro Lys Glu Gly Asp Ile Pro Lys Ser Pro Glu Glu
 305                 310                 315                 320
 Ala Ile Gln Pro Lys Glu Gly Asp Ile Pro Lys Ser Leu Glu Glu Ala
                 325                 330                 335    
 Ile Gln Pro Lys Glu Gly Asp Ile Pro Lys Ser Pro Glu Glu Thr Ile
             340                 345                 350        
 Gln Pro Lys Lys Gly Asp Ile Pro Lys Ser Pro Glu Glu Ala Ile Gln
         355                 360                 365            
 Pro Lys Glu Gly Asp Ile Pro Lys Ser Pro Lys Gln Ala Ile Gln Pro
     370                 375                 380                
 Lys Glu Gly Asp Ile Pro Lys Ser Leu Glu Glu Ala Ile Pro Pro Lys
 385                 390                 395                 400
 Glu Ile Asp Ile Pro Lys Ser Pro Glu Glu Thr Ile Gln Pro Lys Glu
                 405                 410                 415    
 Asp Asp Ser Pro Lys Ser Leu Glu Glu Ala Thr Pro Ser Lys Glu Gly
             420                 425                 430        
 Asp Ile Leu Lys Pro Glu Glu Glu Thr Met Glu Phe Pro Glu Gly Asp
         435                 440                 445            
 Lys Val Lys Val Ile Leu Ser Lys Glu Asp Phe Glu Ala Ser Leu Lys
     450                 455                 460                
 Glu Ala Gly Glu Arg Leu Val Ala Val Asp Phe Ser Ala Thr Trp Cys
 465                 470                 475                 480
 Gly Pro Cys Arg Thr Ile Arg Pro Phe Phe His Ala Leu Ser Val Lys
                 485                 490                 495    
 His Glu Asp Val Val Phe Leu Glu Val Asp Ala Asp Asn Cys Glu Glu
             500                 505                 510        
 Val Val Arg Glu Cys Ala Ile Met Cys Val Pro Thr Phe Gln Phe Tyr
         515                 520                 525            
 Lys Lys Glu Glu Lys Val Asp Glu Leu Cys Gly Ala Leu Lys Glu Lys
     530                 535                 540                
 Leu Glu Ala Val Ile Ala Glu Leu Lys
 545                 550            



      <210> 1125
      <211> 290
      <212> PRT
      <213> Homo sapiens


      <400> 1125
 Met Cys Asn Pro Glu Glu Ala Ala Leu Leu Arg Leu Glu Glu Val Phe
   1               5                  10                  15    
 Ser Ala Thr Leu Ala His Val Asn Ser Leu Val Leu Gln Pro Leu Leu
              20                  25                  30        
 Pro Ala Ala Pro Asp Pro Ser Asp Pro Trp Gly Arg Glu Cys Leu Arg
          35                  40                  45            
 Leu Leu Gln Gln Leu His Lys Ser Ser Gln Gln Leu Trp Glu Val Thr
      50                  55                  60                
 Glu Glu Ser Leu His Ser Leu Gln Glu Arg Leu Arg Tyr Pro Asp Ser
  65                  70                  75                  80
 Thr Gly Leu Glu Ser Leu Leu Leu Leu Arg Gly Ala Asp Arg Val Leu
                  85                  90                  95    
 Gln Ala His Ile Glu Tyr Ile Glu Ser Tyr Thr Ser Cys Met Val Val
             100                 105                 110        
 Gln Ala Phe Gln Lys Ala Ala Lys Arg Arg Ser Glu Tyr Trp Arg Gly
         115                 120                 125            
 Gln Arg Lys Ala Leu Arg Gln Leu Leu Ser Gly Val Ser Ser Glu Gly
     130                 135                 140                
 Ser Val Gly Ala Ser Leu Gly Gln Ala Leu His Gln Pro Leu Ala His
 145                 150                 155                 160
 His Val Gln Gln Tyr Val Leu Leu Leu Leu Ser Leu Gly Asp Thr Ile
                 165                 170                 175    
 Gly Glu His His Pro Thr Arg Glu Leu Val Val Asn Ala Val Thr Leu
             180                 185                 190        
 Phe Gly Asn Leu Gln Ser Phe Met Lys Gln Glu Leu Asp Gln Ala Val
         195                 200                 205            
 Ala Thr Gln Ala Leu Trp His Thr Leu Arg Gly Arg Leu Arg Asp Val
     210                 215                 220                
 Leu Cys Thr Pro Ala His Arg Leu Leu Gln Asp Ser Gln Asp Val Pro
 225                 230                 235                 240
 Val Thr Val Ala Pro Val Gln Ser Leu Ala Ala Ala Arg Gly Thr Gly
                 245                 250                 255    
 Leu Ser Gly Pro Glu Gly Val Pro Phe Leu Lys Leu Trp Cys Leu Gly
             260                 265                 270        
 Asp Leu Leu Ser Thr Leu Leu Gly Thr Cys Arg Cys Pro Ser Arg Ala
         275                 280                 285            
 Gln Phe
     290



      <210> 1126
      <211> 53
      <212> PRT
      <213> Homo sapiens


      <400> 1126
 Met Leu Cys Lys Gln Tyr Met Phe Glu Val Ala Ile Met Arg Glu Asp
   1               5                  10                  15    
 Glu Ala Val Lys Arg Leu Leu Arg Thr Ala Leu Glu Leu Asp Pro His
              20                  25                  30        
 Ser Glu Leu Asp Gln Lys Leu Gln Lys His Ile Met Lys Asn Leu Leu
          35                  40                  45            
 Lys Lys Leu Ile Ser
      50            



      <210> 1127
      <211> 423
      <212> PRT
      <213> Homo sapiens


      <400> 1127
 Met Ile Trp Glu Glu Gln Asn Thr Glu Asp Gln Tyr Lys Asn Pro Arg
   1               5                  10                  15    
 Arg Asn Leu Arg Cys His Met Val Glu Arg Phe Ser Glu Ser Lys Asp
              20                  25                  30        
 Ser Ser Gln Cys Gly Glu Thr Phe Ser Leu Ile Arg Asp Ser Ile Val
          35                  40                  45            
 Asn Asn Ser Ile Cys Pro Gly Glu Asp Pro Cys Gln Ser Ala Glu Cys
      50                  55                  60                
 Glu Glu Val Ile Met Gly His Leu Ser Leu Asn Ser His Ile Arg Val
  65                  70                  75                  80
 Asp Ser Gly His Lys Pro His Glu Tyr Gln Glu Tyr Gly Glu Lys Pro
                  85                  90                  95    
 His Thr His Lys Gln Arg Gly Lys Ala Leu Ser Tyr His His Ser Phe
             100                 105                 110        
 Gln Ser Arg Gly Arg Pro His Thr Gly Lys Lys Arg Tyr Glu Cys Lys
         115                 120                 125            
 Glu Cys Gly Lys Thr Phe Ser Ser Arg Arg Asn Leu Arg Arg His Met
     130                 135                 140                
 Val Val Gln Gly Gly Asn Arg Pro Tyr Lys Cys Lys Leu Cys Gly Lys
 145                 150                 155                 160
 Ala Phe Phe Trp Pro Ser Leu Leu Arg Met His Glu Arg Thr His Thr
                 165                 170                 175    
 Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Ser Lys Ala Phe Pro Phe
             180                 185                 190        
 Tyr Ser Ser Tyr Arg Arg His Glu Arg Met His Thr Gly Glu Lys Pro
         195                 200                 205            
 Tyr Glu Cys Lys Gln Cys Ser Lys Ala Leu Pro Asp Ser Ser Ser Tyr
     210                 215                 220                
 Ile Arg His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr Thr Cys Lys
 225                 230                 235                 240
 Gln Cys Gly Lys Ala Phe Ser Val Ser Ser Ser Leu Arg Arg His Glu
                 245                 250                 255    
 Thr Thr His Ser Ala Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys
             260                 265                 270        
 Thr Phe His His Leu Gly Ser Phe Gln Ile His Met Lys Arg His Thr
         275                 280                 285            
 Gly Asp Arg Pro His Lys Cys Lys Ile Cys Gly Lys Gly Phe Asp Arg
     290                 295                 300                
 Pro Ser Leu Val Arg Tyr His Glu Arg Ile His Thr Gly Glu Lys Pro
 305                 310                 315                 320
 Tyr Glu Cys Lys Gln Cys Gly Lys Thr Leu Ser His Ser Ser Ser Phe
                 325                 330                 335    
 Arg Arg His Met Ile Met His Thr Gly Gly Gly Pro His Lys Cys Lys
             340                 345                 350        
 Ile Cys Gly Lys Ala Phe Val Tyr Pro Ser Val Cys Gln Arg His Glu
         355                 360                 365            
 Lys Ser His Ser Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys
     370                 375                 380                
 Ala Leu Ser His Ser Ser Ser Phe Arg Arg His Met Val Met His Thr
 385                 390                 395                 400
 Gly Asp Gly Pro Asn Lys Cys Lys Val Cys Gly Lys Ala Phe Val Tyr
                 405                 410                 415    
 Pro Ser Val Cys Gln Ser Thr
             420            



      <210> 1128
      <211> 109
      <212> PRT
      <213> Homo sapiens


      <400> 1128
 Met Ala Phe Lys Glu Ile Lys Lys Ala Leu Thr Trp Ala Pro Ala Leu
   1               5                  10                  15    
 Gly Leu Pro Asp Met Thr Lys Pro Phe Tyr Leu Tyr Val His Glu Arg
              20                  25                  30        
 Lys Gly Met Ala Thr Gly Val Leu Val Gln Thr Leu Glu Ser Trp Tyr
          35                  40                  45            
 Trp Pro Val Ala Tyr Leu Ser Lys Gln Leu Asp Leu Val Ala Met Gly
      50                  55                  60                
 Trp Pro Pro Cys Phe Lys Ala Leu Ala Ala Thr Ala Leu Leu Ala Glu
  65                  70                  75                  80
 Asp Ala Asn Lys Leu Thr Phe Gly Gln Lys Leu Ile Ile Arg Val Pro
                  85                  90                  95    
 His Thr Val Val Thr Leu Met Glu Gln Arg Gly His Arg
             100                 105                



      <210> 1129
      <211> 665
      <212> PRT
      <213> Homo sapiens


      <400> 1129
 Met Gln Gln Glu Gly Thr Ile Tyr Glu Glu Ala Arg Thr Ser Pro Asp
   1               5                  10                  15    
 Thr Glu Ser Val Gly Ala Leu Met Gly Leu Leu Ser Leu Gln Asn Tyr
              20                  25                  30        
 Leu Lys Gln Ile Lys Ile Asp Leu Gly Lys Phe Ser Asp Asn Pro Asp
          35                  40                  45            
 Gly Tyr Val Asp Val Leu Gln Gly Leu Gly Gln Ser Phe Asp Leu Thr
      50                  55                  60                
 Trp Arg Asp Ile Met Leu Leu Leu Asp Gln Thr Leu Thr Pro Asn Lys
  65                  70                  75                  80
 Arg Ser Ala Ala Ile Thr Val Ala Arg Glu Phe Gly Asp Leu Trp Tyr
                  85                  90                  95    
 Leu Asn Gln Val Asn Asp Ser Met Thr Thr Glu Glu Arg Glu Gln Phe
             100                 105                 110        
 Pro Thr Gly Gln Gln Tyr Pro Leu Arg Ser Thr Gln Leu Ser Asp Gly
         115                 120                 125            
 Gln Pro Asn Lys Pro Gln Leu Gly Leu Gln Lys Ile Val Lys Asp Leu
     130                 135                 140                
 Lys Ala Gln Gly Leu Val Lys Pro Cys Asn Ser Pro Cys Asn Thr Pro
 145                 150                 155                 160
 Ile Leu Gly Val Gln Lys Pro Asn Gly Gln Trp Arg Leu Val Gln Asp
                 165                 170                 175    
 Leu Arg Ile Ile Ser Glu Ala Val Val Pro Leu Tyr Pro Ala Val Pro
             180                 185                 190        
 Asn Pro Tyr Thr Leu Leu Ser Gln Ile Pro Glu Glu Ala Glu Trp Phe
         195                 200                 205            
 Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Ile Pro Val His Pro
     210                 215                 220                
 Asp Ser Gln Phe Leu Phe Ala Phe Glu Asp Pro Leu Asn Pro Thr Ser
 225                 230                 235                 240
 Gln Leu Thr Trp Thr Ala Leu Pro Gln Val Phe Arg Asp Ser Pro His
                 245                 250                 255    
 Leu Phe Asp Gln Ala Leu Ala Gln Asp Leu Ser Gln Phe Ser Tyr Leu
             260                 265                 270        
 Asp Thr Leu Ala Leu Trp Tyr Val Asp Asp Leu Leu Leu Ala Ala Arg
         275                 280                 285            
 Ser Glu Thr Leu Cys His Arg Val Thr Gln Ala Leu Leu Asn Phe Leu
     290                 295                 300                
 Ala Thr Cys Gly Tyr Lys Val Ser Lys Pro Lys Ala Gln Phe Cys Leu
 305                 310                 315                 320
 Gln Gln Val Lys Tyr Leu Gly Leu Lys Leu Ser Lys Gly Thr Arg Ala
                 325                 330                 335    
 Leu Met Ser Pro Ser Ser Leu Val Val Glu Ala Ser Pro Trp Ser Pro
             340                 345                 350        
 Gly Val Gln Ala Pro Leu Trp Arg Gln Leu Leu Ala Pro Ser Pro Trp
         355                 360                 365            
 Asp Arg Ser Arg Gly Gly Leu Cys Arg Gly Ala Gly Trp Lys Arg Trp
     370                 375                 380                
 Pro Leu Arg Gly Ala Ala Gly Glu Ser Thr Asp Leu Pro Arg Thr Pro
 385                 390                 395                 400
 Gly Arg Gly Gly Gly Arg Ser Lys Ser Thr Gly Val Glu Gly Gly Gln
                 405                 410                 415    
 Cys Gly Ala Asp Ala Cys Val Pro Ser Ser Asp Thr Gly Arg Val Val
             420                 425                 430        
 Asp Val Arg Arg Val Trp Leu Gly Tyr Leu Ser Ser Lys Pro Pro Val
         435                 440                 445            
 Ser Ile Arg Glu Leu Ala Val Thr Met Ala Met Arg Glu Leu Val Glu
     450                 455                 460                
 Ala Glu Cys Gly Gly Ala Asn Pro Leu Met Lys Leu Ala Gly His Phe
 465                 470                 475                 480
 Thr Gln Asp Lys Ala Leu Arg Gln Glu Gly Leu Arg Pro Gly Pro Trp
                 485                 490                 495    
 Pro Pro Gly Ala Pro Ala Ser Glu Ala Val Ser Val Leu Glu Val Glu
             500                 505                 510        
 Ser Pro Gly Ala Ala Ser Glu Ala Val Ser Val Leu Glu Val Glu Ser
         515                 520                 525            
 Pro Gly Ala Ala Ser Glu Ala Ala Ser Lys Pro Leu Gly Val Ala Ser
     530                 535                 540                
 Glu Asp Glu Leu Val Gly Glu Phe Leu Gln Asp His Ser Val Pro Leu
 545                 550                 555                 560
 Tyr Pro Val Pro Leu Arg Pro Ser Arg Trp Met Asn Ser Trp Leu Arg
                 565                 570                 575    
 Cys Ser Arg Leu Lys Ser Gln Thr Ser Ser Arg Leu Pro Arg Glu Pro
             580                 585                 590        
 Leu Val Trp Pro Thr Trp Pro Cys Leu Arg Thr Gly Pro Arg Val Thr
         595                 600                 605            
 Cys Ser Trp Arg Cys Arg Arg His Arg Leu Val Cys Met Ala Leu Phe
     610                 615                 620                
 Ser Gly Glu Ala Leu Gly Glu Arg Leu Val Leu Arg Arg Leu Trp Tyr
 625                 630                 635                 640
 His Leu Ser Cys Leu Asn Lys Arg Met Thr Val Tyr Ile Leu Asp Ser
                 645                 650                 655    
 Ser Met Ile Pro Glu Lys Lys Ile Phe
             660                 665



      <210> 1130
      <211> 498
      <212> PRT
      <213> Homo sapiens


      <400> 1130
 Met Arg Arg Tyr Thr Thr Leu Lys Lys Asn Cys Leu Ser Phe Val Thr
   1               5                  10                  15    
 Tyr Ile Thr Glu Ile Trp Ile Thr Gly Met Gly Met Tyr Ile Lys Gly
              20                  25                  30        
 Asp Leu Leu Pro Phe Thr Arg Ala Thr Val His Trp Gly Lys Gly Tyr
          35                  40                  45            
 Asp Arg Thr Phe Trp Gly Leu Leu Asp Thr Gly Ser Glu Leu Thr Leu
      50                  55                  60                
 Thr Pro Gly Asp Pro Lys His His Cys Gly Pro Pro Val Lys Val Gly
  65                  70                  75                  80
 Val Tyr Glu Asn Gln Thr His Pro Val Val Ile Ser Pro Val Pro Lys
                  85                  90                  95    
 Cys Ile Ile Gly Ile Asp Ile Leu Ser Ser Trp Gln Asn Thr His Val
             100                 105                 110        
 Ser Ala Leu Thr Gly Tyr His Thr Val His Tyr Ile Asp Asp Ile Ile
         115                 120                 125            
 Leu Ile Gly Ser Ser Glu Gln Glu Val Ala Asp Thr Leu Asp Leu Leu
     130                 135                 140                
 Val Lys Asn Lys Leu Leu His Leu Ala Pro Pro Thr Thr Lys Lys Gly
 145                 150                 155                 160
 Thr Thr Pro Lys Gln Glu Lys Ala Leu Gln Gln Val Gln Ala Ala Val
                 165                 170                 175    
 Gln Ala Ala Leu Pro Leu Gly Pro Tyr Asp Pro Ala Asp Pro Met Val
             180                 185                 190        
 Leu Glu Val Ser Leu Ala Asp Arg Asp Ala Val Trp Ser Leu Trp Gln
         195                 200                 205            
 Ala Pro Leu Ala Thr Pro Val Ile Ala Gln Trp Ala His Glu Gln Ser
     210                 215                 220                
 Gly His Gly Gly Arg Asp Gly Gly Tyr Ala Trp Ala Gln Gln Leu Gly
 225                 230                 235                 240
 Leu Pro Leu Thr Lys Ala Asp Leu Ala Thr Ala Ala Ala Glu Cys Pro
                 245                 250                 255    
 Ile Cys Gln Gln Gln Arg Pro Thr Leu Ser Pro Gln Tyr Gly Thr Ile
             260                 265                 270        
 Pro Arg Ala Ala Thr Trp Ile His Gly Ser Arg Asn Gln Gly Val Glu
         275                 280                 285            
 Val Glu Val Ala Pro Leu Thr Ile Thr Ser Ser Asp Pro Leu Gly Lys
     290                 295                 300                
 Phe Leu Leu Pro Val Pro Met Ile Leu His Ser Ala Gly Leu Glu Val
 305                 310                 315                 320
 Leu Val Pro Glu Gly Gly Thr Leu Pro Pro Gly Asp Thr Thr Thr Ile
                 325                 330                 335    
 Pro Leu Asn Trp Lys Leu Arg Leu Pro Pro Gly His Phe Gly Leu Leu
             340                 345                 350        
 Leu Pro Leu Ser Gln Gln Ala Lys Arg Gly Val Thr Val Leu Asp Gly
         355                 360                 365            
 Thr Ile Asp Leu Asp Tyr Gln Asp Glu Ile Ser Leu Leu Leu His Asn
     370                 375                 380                
 Gly Glu Leu Pro Lys Phe Leu Tyr Glu Lys Gln Ser Gln Pro Glu Pro
 385                 390                 395                 400
 Pro Gly Ser Gly Val Pro Ser His Pro Glu Arg Arg Leu Gly Pro Leu
                 405                 410                 415    
 Glu Lys Val Pro Ser Gln Lys Val Phe Phe Leu Leu Pro Tyr Arg Leu
             420                 425                 430        
 Asp Gln Phe Ser Lys Gln Phe Leu Cys Gln Arg His Tyr Val Ala Glu
         435                 440                 445            
 Asn Gly Arg Ala Ser Trp Asp Val Asp Arg Thr Cys Asp Leu Pro Leu
     450                 455                 460                
 Ala Met Glu Cys Gly Arg Gly Asp Arg Met Leu Leu Gln Cys Asp Tyr
 465                 470                 475                 480
 Val Pro Leu Ala Gly Arg Leu Ile Leu Gly Thr Leu Trp Gln Thr Leu
                 485                 490                 495    
 Lys Lys
        



      <210> 1131
      <211> 168
      <212> PRT
      <213> Homo sapiens


      <400> 1131
 Met Thr Ser His Ala Arg Val Arg Lys Leu Gly Ser Ser Arg Ala Ala
   1               5                  10                  15    
 Pro Thr Thr Thr Ile Arg Leu Arg Glu Asp Asp Arg Arg Glu Ser Gly
              20                  25                  30        
 Phe Gly Trp Ala Ile Trp Met Glu Gly Leu Val Phe Ser Arg Leu Ser
          35                  40                  45            
 Pro Glu Tyr Tyr Asp Leu Ala Arg Ala His Leu Arg Asp Glu Glu Lys
      50                  55                  60                
 Ser Cys Pro Cys Leu Ala Gln Glu Gly Pro Gln Gly Asp Leu Leu Thr
  65                  70                  75                  80
 Lys Thr Gln Glu Leu Gly Arg Asp Tyr Arg Thr Cys Leu Thr Ile Val
                  85                  90                  95    
 Gln Lys Leu Lys Lys Met Val Asp Lys Pro Thr Gln Arg Ser Val Ser
             100                 105                 110        
 Asn Ala Ala Thr Arg Val Cys Arg Thr Gly Arg Ser Arg Trp Arg Asp
         115                 120                 125            
 Val Cys Arg Asn Phe Met Arg Arg Tyr Gln Ser Arg Val Thr Gln Gly
     130                 135                 140                
 Leu Val Ala Gly Glu Thr Ala Gln Gln Ile Cys Glu Asp Leu Arg Leu
 145                 150                 155                 160
 Cys Ile Pro Ser Thr Gly Pro Leu
                 165            



      <210> 1132
      <211> 197
      <212> PRT
      <213> Homo sapiens


      <400> 1132
 Met Ala Asp Lys Val Leu Lys Glu Lys Arg Lys Leu Phe Ile His Ser
   1               5                  10                  15    
 Met Gly Glu Gly Thr Ile Asn Gly Leu Leu Asp Glu Leu Leu Gln Thr
              20                  25                  30        
 Arg Val Leu Asn Gln Glu Glu Met Glu Lys Val Lys Arg Glu Asn Ala
          35                  40                  45            
 Thr Val Met Asp Lys Thr Arg Ala Leu Ile Asp Ser Val Ile Pro Lys
      50                  55                  60                
 Gly Ala Gln Ala Cys Gln Ile Cys Ile Thr Tyr Ile Cys Glu Glu Asp
  65                  70                  75                  80
 Ser Tyr Leu Ala Glu Thr Leu Gly Leu Ser Ala Ala Leu Gln Ala Val
                  85                  90                  95    
 Gln Asp Asn Pro Ala Met Pro Thr Cys Ser Ser Pro Glu Gly Arg Ile
             100                 105                 110        
 Lys Leu Cys Phe Leu Glu Asp Ala Gln Arg Ile Trp Lys Gln Lys Leu
         115                 120                 125            
 Gln Arg Cys His Val Gln Asn Thr Ile Ile Lys Trp Ser Glu Arg Tyr
     130                 135                 140                
 Thr Ser Gly Ser Phe Glu Met Gln Trp Leu Phe Leu Arg Thr Asn Phe
 145                 150                 155                 160
 Ile Glu Arg Phe Trp Arg Asn Ile Leu Leu Leu Pro Leu His Lys Gly
                 165                 170                 175    
 Ser Leu Tyr Pro Arg Ile Pro Gly Leu Gly Lys Glu Leu Gln Thr Gly
             180                 185                 190        
 Thr His Lys Leu Ser
         195        



      <210> 1133
      <211> 148
      <212> PRT
      <213> Homo sapiens


      <400> 1133
 Met Gly Leu Trp Leu Lys Pro Ser Arg Gly Cys Val His Arg Ala Leu
   1               5                  10                  15    
 Arg Ser Ala Arg Glu Ala Arg Pro Ser Pro Pro Arg Ala Arg Thr Ser
              20                  25                  30        
 Pro Arg Leu Ser Pro Val Gly Gly Gly Ala Gly Thr Ser Leu Gln Cys
          35                  40                  45            
 Phe Lys Gly Thr Leu Val Ile Phe Cys Ser Ala Arg Gly Ser Arg Cys
      50                  55                  60                
 Ala Leu Glu Ser Arg Cys Phe Leu Tyr Pro Gln Gly Asn Pro Gly Ser
  65                  70                  75                  80
 Gly Phe Arg Leu Glu Asn Lys Thr Thr Ala Asp Gly Asn Tyr Pro Pro
                  85                  90                  95    
 Gly Ser Leu Val Lys Gly Cys Phe Trp Ser Arg Ile Ser Thr Cys Val
             100                 105                 110        
 Pro Val Cys Val Ala His Pro Pro Gln Glu Gln Pro Arg Asn Phe Pro
         115                 120                 125            
 Trp Asn Leu Pro Phe Pro Thr Thr Pro Gly Pro Gly Glu Asp Ile Ile
     130                 135                 140                
 His Ile Ser Glu
 145            



      <210> 1134
      <211> 437
      <212> PRT
      <213> Homo sapiens


      <400> 1134
 Met Glu Glu Lys Asn Gln Ala Val Cys His Asp Tyr Asp Ile His Phe
   1               5                  10                  15    
 Tyr Pro Thr Phe Arg Tyr Phe Lys Ala Phe Thr Lys Glu Phe Thr Thr
              20                  25                  30        
 Gly Glu Asn Phe Lys Gly Pro Asp Arg Glu Leu Arg Thr Val Arg Gln
          35                  40                  45            
 Thr Met Ile Asp Phe Leu Gln Asn His Thr Glu Gly Ser Arg Pro Pro
      50                  55                  60                
 Ala Cys Pro Arg Leu Asp Pro Ile Gln Pro Ser Asp Val Leu Ser Leu
  65                  70                  75                  80
 Leu Asp Asn Arg Gly Ser His Tyr Val Ala Ile Val Phe Glu Ser Asn
                  85                  90                  95    
 Ser Ser Tyr Leu Gly Arg Glu Val Ile Leu Asp Leu Ile Pro Tyr Glu
             100                 105                 110        
 Ser Ile Val Val Thr Arg Ala Leu Asp Gly Asp Lys Ala Phe Leu Glu
         115                 120                 125            
 Lys Leu Gly Val Ser Ser Val Pro Ser Cys Tyr Leu Ile Tyr Pro Asn
     130                 135                 140                
 Gly Ser His Gly Leu Ile Asn Val Val Lys Pro Leu Arg Ala Phe Phe
 145                 150                 155                 160
 Ser Ser Tyr Leu Lys Ser Leu Pro Asp Val Arg Lys Lys Ser Leu Pro
                 165                 170                 175    
 Leu Pro Glu Lys Pro His Lys Glu Glu Asn Ser Glu Ile Val Val Trp
             180                 185                 190        
 Arg Glu Phe Asp Lys Ser Lys Leu Tyr Thr Val Asp Leu Glu Ser Gly
         195                 200                 205            
 Leu His Tyr Leu Leu Arg Val Glu Leu Ala Ala His Lys Ser Leu Ala
     210                 215                 220                
 Gly Ala Glu Leu Lys Thr Leu Lys Asp Phe Val Thr Val Leu Ala Lys
 225                 230                 235                 240
 Leu Phe Pro Gly Arg Pro Pro Val Lys Lys Leu Leu Glu Met Leu Gln
                 245                 250                 255    
 Glu Trp Leu Ala Ser Leu Pro Leu Asp Arg Ile Pro Tyr Asn Ala Val
             260                 265                 270        
 Leu Asp Leu Val Asn Asn Lys Met Arg Ile Ser Gly Ile Phe Leu Thr
         275                 280                 285            
 Asn His Ile Lys Trp Val Gly Cys Gln Gly Ser Arg Ser Glu Leu Arg
     290                 295                 300                
 Gly Tyr Pro Cys Ser Leu Trp Lys Leu Phe His Thr Leu Thr Val Glu
 305                 310                 315                 320
 Ala Ser Thr His Pro Asp Ala Leu Val Gly Thr Gly Phe Glu Asp Asp
                 325                 330                 335    
 Pro Gln Ala Val Leu Gln Thr Met Arg Arg Tyr Val His Thr Phe Phe
             340                 345                 350        
 Gly Cys Lys Glu Cys Gly Glu His Phe Glu Glu Met Ala Lys Glu Ser
         355                 360                 365            
 Met Asp Ser Val Lys Thr Pro Asp Gln Ala Ile Leu Trp Leu Trp Lys
     370                 375                 380                
 Lys His Asn Met Val Asn Gly Arg Leu Ala Gly Glu Lys Pro Leu Gly
 385                 390                 395                 400
 Met Gly Gly Ser Ala Arg Ala Glu Gly Gly Pro Gly Pro Gly Thr Ala
                 405                 410                 415    
 Arg Thr Ala Arg Leu Pro Trp Gly Leu Ser Leu Ser Phe Ala Ala Ser
             420                 425                 430        
 Cys His Pro Leu Cys
         435        



      <210> 1135
      <211> 1743
      <212> DNA
      <213> Homo sapiens


      <400> 1135
 caggcctggt ctctgataac gggatgggtg gtgctggacc tcgggcgggg ccgggcctcg     60
 tggcgggagg aggcagggca gggcctctgg gacggggctg gacggcttgt tgacggaaac    120
 gagcccttga cgctgtggcc cggaagtgga gcggctgtcg cagtgcggct ccggcagtgg    180
 cagcggaggc ctgtgtttgc ggccttcggc aagcgactga gatggcgagc gcaactgcac    240
 cctgcagccg cagtccccac ccctggcttc gccctttgga gcagctccgg cacttggcgg    300
 aggagctgcg gtttgctcct gcctcgagtg cgggtcggcg aagcccagga gaccaccgag    360
 gagtttaatc gagagatgtt ctggagaaga ctcaatgagg cagctgtgac tgtgtcaagg    420
 gaagccacga gctctgacca tagtcttctc tcagcttcca cttgccgtct ccacaggaaa    480
 cccagaagtt cttgttgaac aagtccatgg ttgccatcaa ggcattttat ttgcagtgta    540
 ctatttgctt ccaaaggatc aggggatcac cctgaagaaa gctggttacg ggggcgccac    600
 cctggacatc gtggatgggc atggctcagc tcatggaagt actttccgtc actccaactc    660
 agagccctga gaacaatgac cttatttcct acaacagtgt ctgggttgcg tgccagcaga    720
 tgcctcagat accaagagat aacaaagctg cagctctttt gatgctgacc aagaatgtgg    780
 ggttttgtga aggatgcaca tgaagaaatg gagcaggctg tggaagaatg tgacccttac    840
 tctggcctct tgaatgatac tgaggagaac aactctgaca accacaatca tgaggatgat    900
 gtgttggggt ttcccagcaa tcaggacttg tattggtcag aggacgatca agagcatcat    960
 aatcccatgc cctggcgctg gtcagagcat caaaagcctg cctgaagaaa attcggatgt   1020
 tacgtggcag agaatgggaa gaaggatcag gtggccacag ctgggatgac attgtgggat   1080
 atttctgatt gaaatcagcc ctagtgtggg atgatttggg ctcctgagca tatatcccac   1140
 ctatgtgtca ccctgaccgg tgcgaatcaa tttctggcga aacttgtatt ctgttttaaa   1200
 gaagggcact ttgaaaatta ccaaaagcaa gtcatgttga cccctcagcc agaagatagg   1260
 ttggatccct ttaccttatt taatgcccat ggatcatggc catgaatgga atccagggag   1320
 ctccactcca ggagtgaact tgaaattatg gaccttttcc aggcctccat ttggtactct   1380
 cttccccctc tccatcgtcc atggtccagg ctctgatacc ctgcctttta aaatggagcc   1440
 tagaatgcct tgcctggatt gaaaggggag tgccctatcc tatatttagc caagagacac   1500
 tattacccaa agattgttgg gttagggcca gattggacac ctatttataa acccatatgc   1560
 ggtatatttt tcctgtgcta tatatgaaaa ataattgcat gatttctcat tcctgagtca   1620
 tttctcagag attcctagga aagctgcctt tattctcttt ttgcagtaaa gtatgttgta   1680
 ttcattggaa agatgttgat ggtctcaata aaaagctaac ttgcccagtg attaaaaaaa   1740
 aaa                                                                 1743



      <210> 1136
      <211> 390
      <212> DNA
      <213> Homo sapiens


      <400> 1136
 cgcttccgca aagctcagtg taccattgtg gagcgcctca ctaactccat gatgatgcac     60
 ggccgcaaca acggcaagaa gctcatgact gtgcgcatcg tcaagcatgc cttcgagatc    120
 atacacctgc tcacaggcga gaaccctctg caggtcctgg tgaacgccat catcaacatg    180
 tgtcccccct gcgccgtgtg aaccatgcca tctggctgct gtgcacaggc gctcgtgagg    240
 ctgccttccg gaacattaag accattgctg agtgcctggc agatgagctc atcaatgctg    300
 ccaagggctc ctcgaactcc tatgccatta agaacaagga cgagctggag cgtgtggcca    360
 agtccaaccg atgattttcc cagctgctgc                                     390



      <210> 1137
      <211> 390
      <212> DNA
      <213> Homo sapiens


      <400> 1137
 tttcgtgcgg cggcgacggt cgggcggcac actttacctg agcattggtc ctacggggtg     60
 tgccgggatg gccgcgtctt cttcatcaat gaccagctcc gctgcacgac ctggctgcac    120
 ccgcgcaccg gggagcccgt caactcgggc cacatgatcc gctcatacct gccccgcggc    180
 tgggaggagg gcttcacgga ggagggcgcc agctacttca tcgaccataa ccagcagacc    240
 acagcattca ggcatcctgt gacgggacag ttttctccag aaaatagtga attcattctt    300
 caagaagagc cgaatccaca tatgtcgaag caagacagaa accaaagacc gtccagcatg    360
 gtcagtgaaa catccacggc tgggaccgcc                                     390



      <210> 1138
      <211> 485
      <212> DNA
      <213> Homo sapiens


      <400> 1138
 gcgcggagag acgcagcgga ggttttcctg gtttcggacc ccagcggccg gatggtgaaa     60
 ttctccctgc agcggatcct caatagccac tgcttcgcca gagagaagga aggggataaa    120
 cccagcgcca ccatccacgc cagccgcacc atgccgctcc taagcctgca cagccgcggc    180
 ggcagcagca gtgagaggat gatcggctga atgtaacaga ggaactaacg tccaacgaca    240
 agacgaggat tctcaacgtc cagtccaggc tcacagacgc caaacgcatt aactggcgaa    300
 cagtgctgag tggcggcagc ctctacatcg agatcccggg cggcgcgctg cccgagggga    360
 gcaaggacag ctttgcagtt ctcctggagt tcgctgagga gcagctgcga gccgaccatg    420
 tcttcatttg cttccacaag aaccgcgagg acagagccgc cttgctccga accttcagct    480
 ttttg                                                                485



      <210> 1139
      <211> 1285
      <212> DNA
      <213> Homo sapiens


      <400> 1139
 cacacgtccg gctaattttt gtatttttag tagagacagg gtttcgccat gttggccagg     60
 ctggtctgga actcctgact tcacgtgatc catctgcctc ggcctcccaa agtgctggga    120
 ttacgggcgt gagccacagt gcccagccaa aatgcgacac ttcttccctg tctagcagtg    180
 caagatctta aagtcagatt ataaaacaag ttgtattctc actttatcat ttttctctgc    240
 agttctaggg caggtttatc tgaattactt aagtccttca tagtatagtg agcataaaag    300
 aggacacaag ccaaatgtat acttaaatta aatagcatga tttaatttag ttggtgctta    360
 accctgaatc ctcttaagtt aaaaaaaaag ttataattaa ctattaacgt taatgaattt    420
 aaaccttcca gaaagcatga atccaaaagg aaatgtccaa caggtgatat gaaccagata    480
 ttttatggcc tttcctgttt cagtctcaaa ctttctaaac atcaatgggg aaaaaaaatt    540
 ctctagagtt tttcagtttt attcttctag agcacaattt tccggcctgt tactgagtac    600
 ggtcttctaa caggtacaca attaactcat aagtagacaa cacaatggca gtatttggga    660
 tctgccggat aagctgggca aacagtcctc tataaaaggc aaggtagcct tcttcccgga    720
 acaccaggcg cgccgtctgg acaaaagact tgtacttggt gccctcttcc cggagcctcg    780
 tccttatgac ttcgtgtgga taagcaatgc aggaggcaca gcccttagaa agagcagcag    840
 ctgccataag tccaaaaaaa cttgtggaat ttttctcagt cccatttgca gaagaggcta    900
 atggagcttc tttcagatac ttctttaaac tttcataaat agcaaagcag attatagttt    960
 cggaaattcc agcatacgag gcagttaatc ctctatagaa gccacgaatg ccttcggtct   1020
 ggtaaacgta acgagcacac tggagtgtat tcatctgctt agagcccctc actttctgtt   1080
 ctagctgcat tcgggtttta accatccata taggattcat taaggaattt gtgataaaag   1140
 ctgcagagcc agctgagaaa atatgcacaa tattgctgtt aggcacgaaa atgccattaa   1200
 attgctcttt ggctttggag taacatgcaa agtatacagc ccttgatggt gcaactccaa   1260
 ccaaatttgg acccaagcct ctaaa                                         1285



      <210> 1140
      <211> 1122
      <212> DNA
      <213> Homo sapiens


      <400> 1140
 cgtgtggagg aattcgtcag atctgggtgt catactatca gaattccctc tggcccctga     60
 gctggccaaa gccctgctgg cctcatgcga gtttgactgt gtggacgaga tgctcaccct    120
 ggctgccatg ctcacagctg cccctgggtt tacccgtcct ccactcagtg cagaagaagc    180
 tgccctgcgt cgggccctgg aacacacgga tggtgaccac agttctctga tccaggtgta    240
 tgaagccttt atacaaagtg gagcagatga ggcttggtgc caggctcgag gtctgaattg    300
 ggcagcattg tgccaagccc ataaacttcg gggagaactc ctagaactca tgcaacgaat    360
 tgaacttccc ttgtccctac cagcctttgg ctctgagcag aatcgcagag accttcagaa    420
 agcactggtg tcaggatact ttctcaaggt ggccagagac acagacggga ctggaaatta    480
 cctactccta acccataagc atgtggccca gctctcctca tactgctgct accgaagccg    540
 cagagctcct ggccagaccc ccaccatggg tggcttttac cacaattttc accatatcca    600
 aagacaactg cctttccatt gtttctgaga ttcaaccaca gatgctggtg gaattggccc    660
 ctccatactt cctgagtaac ttgcctccca gtgagagcag agaccttctg aaccagctaa    720
 gggaaggaat ggcagattct acagcaggga gcaaatcatc cctcagcccc cggagttcag    780
 agatcccctg tgtccctgca gtgaccctgc ctgccctatg gaatggagct gggttcatct    840
 catcacatta gattatccct cagggtgaca ccaaagcacc cagacagatt tagaagccca    900
 aagtttaggg tcaaatgtaa accctggaac ctgagtccca agaaatggta gactgggaat    960
 ggaaagaatg gggtaaacca cagtctacat agggaaggac tctttcctta gccttctctt   1020
 attgattgga gagggactga catgctcctc attctcttaa ctttgccaaa cccattcttg   1080
 tactcccttg tgatctataa aagatttttc tatgatgcca aa                      1122



      <210> 1141
      <211> 4700
      <212> DNA
      <213> Homo sapiens


      <400> 1141
 tttttttttt tttaagtcag aaacaggaaa cgtttattta aatagtgtag tcttaatttc     60
 tttaatataa aaccccccca aatctgatga aaacaaagtt ttatatacca tataaacaag    120
 atttgtcaga tttgaaagtg aaagttaaag taatttacag ttagctttta accctctcgg    180
 gacatttaga tacatcctcg ataatccatc ttgtaattag tgtgtgtcaa ttttacaata    240
 cactggggga aaactcaggc tattgtattt aacgggtaca gtttcattta tcaaagtgtt    300
 tcccattaat tcccattatt aggtggacag ctaaccaagt gaccccatca aaatgaagtg    360
 aatgacatta gactgtggcc agagtgaacc acatctggga ttggctttct ataattcacc    420
 cagtttgcgg ggaagtaaac attctttgga tttgttcata atatactgaa gttacctata    480
 acactggtgc agtaacacag ctagttcctc tgtattggtt atgggtaaga acgggatttt    540
 ggtaatataa agttaacagg aaaaaaatgc ttcacacatt atgtggtgga aacttatctc    600
 cacaaaaaga ccattaaaat aaaaaggata gagggaaaaa taaaccatgc agaagagacg    660
 gcttccccca tcttccaacc tgtttcccat gggctcactc attgcccata catcacttgc    720
 cacactatca agtgactcct ttctgctttg gtgacagaag gttcaagtgg aagatcctct    780
 ccaagaagtt ctgattctcc accttcatca cccattcgga agtcgatgta gccctctcct    840
 ccactgatga caagcataga cttcaagggc gtctgactac caggctcctg tgcagatggc    900
 ccctgccttt gtcacccgtc agatccgtgc cactactgct actttgtggg ctgatgactt    960
 gacctgggac tgccacaaag aatttcacag catcccggtg cccatggaag caaagctgtg   1020
 catgtgccat tgaacaatag ggtataaatg tccctggagt cactttatca ctgttttcat   1080
 caccatatac acggattaca cttccaggac gatttcctgg tacacctgag gttttatttg   1140
 ccctcagccc cagtaaacgt ccctggtgga ggattacggt ttctgtcaat gggatggaga   1200
 taatgacacc atttcctgtc cccacccaca aacgattaca agacaccata agagctgtaa   1260
 ttctcacaaa agagaagccc agttttccag tacctaacat tttgcttaca taaggctcaa   1320
 tgtccacatc ctgtagatgt tgataagtgt gtgcatgata gagacggagc gtagaatcca   1380
 agcgaatgga gacccacacg ccatccccca cccacgcaag ctgtcgcact tggctctcct   1440
 tcctgggatg tgcatcaaaa gatttctcta ttttcatggc ctttggctgc accacataga   1500
 ttttgttcct atagccacac cagactttgt catgtaccac agtcatgcaa cggatggaat   1560
 gatgaggccg tccaaggtct aagaggtgat agtttgacaa atcccactgc ccatccactc   1620
 ctctgtgaaa gattgcaagg gtgccgtcag ccagggctac taacacgatt cccttcacgt   1680
 gtacaatact gagaatcgaa tctttaagtt taatggaatg gagacatttc ctccactggg   1740
 ctacagatga atggacatac aaacagccat tttgagctcc aagccacata gttggtaaaa   1800
 gactactcat tttctgggct tcttctctca ccaagtcttg ttcatttggc agtactgata   1860
 tttgatcttt atatgcatct gagtcattgc tcgactgata cactggggag aggtcttctg   1920
 ggatctgaac ttcccaaagg atctgtaaag acatgctctg tgtagacgcc agtttgggag   1980
 atgtccaact gtgtcttcag ctgaccccgc attcccttct gtagcttcag ttgctttctt   2040
 ctgctgttgg aacattttca tcaacctcac tattttctgc ttccatttct ggtggtttat   2100
 ccatcactgg agaagcacca tttgtactag gggaagtggc agctcccgtc acaccttctg   2160
 cagaacaacc aaccactgtg atgcctccta acaggctgtc tgtctctgct gagctgttgc   2220
 ttgtcatact tccacataaa gatgctttgt ctacctgacc agattctgaa agatcttctc   2280
 ctgcagggta gtctgtttct cgtgcacctg gcacacttgc aatgcacaga acatgagagt   2340
 tgcaaacagt gaaactgtct aggatgttgc caggttgaac agcatcaata ataagaactt   2400
 ttgtagccga atgagtgctg gtacagatcc aaactagact ggataattct tcttgatttt   2460
 ttaactcctt ctgctgttcc ttaagttcct gatctaactt atctaaacta ctctgagagg   2520
 cacttcgctg tttactgcct tctgtatcca aaccagcaac atccttgtaa aatacacttg   2580
 ctccaacaac agaaccacca tctctggtct tcccaccaga taaattgact ccaacagcac   2640
 accacagctt cattgatgta tcttttttat ccagaggtct gagatagaca ggcacaggta   2700
 aatttttcat cttattttca ccttgaccat tggttacctg tttgtacttc tgaggcagac   2760
 tccagccaaa agcctgcact ctaccgtctt ccttctgaac atgtgctttt acctgacgat   2820
 actgctctct cttttgttct ctgcgtgagg ctaaactagc ttcagtttct tcactaagga   2880
 aatcaaaggc tttggactta tccccaggga gctgagataa ggtgctgctt cttttcttga   2940
 cggacggagt aacatgagac gtgggtgcat tgtacttcag attaacaggt ggttcaggct   3000
 tcttagtcgt gttacttgag gagctgaaaa gtcggctaaa aaactgccaa atgcttgacc   3060
 tttttttttc ctgcatggct ggattttctc gtgatgcccg aatcatctct gtccatcgaa   3120
 cagcttcctg aagctccatc aatctctctt tatactggtt tcgctccatg agaacacggg   3180
 ccatttctac tctagtaaac cgtttcctct gggctgtggg aatatcacta tcatcgtcat   3240
 cttttgcttt ttgccttgca tcttcagctt ctgcccgagc tttcctaagc tcttcctcca   3300
 attctctgtt cttttcctct agtttcagtt tggcttgctt cacagcctcc aattcccctt   3360
 gcagcacatc tttctcacag gtcagttcat ccacttttgc tatcaaatca ttcttcacta   3420
 tgttcaaagc atttttggtt tccaacagtt gtgtattttc taatataaga ttctcaactt   3480
 cccgacccat tcctagtaaa tctgctcctt catccacatc tcctattagg cctgagccag   3540
 ctgaagacag ttcttcaaag agagattctg tattgcgatc aaaagctttg ttctctatgc   3600
 ctttggtggg agtgcttgaa cctttatatc cactgagatc tttgtccata tccagctcag   3660
 gagtagattc gatgattgct tgaacttctg acttttcttc attttcagca gagccagtag   3720
 atacatttct agtttcctgg gctacctgta cttcaatgtg tttgcttatc tctgatttat   3780
 ttggcgcatc tgtaaccttc acaaatcctt cgttttcttc ctttaaggga gtatcagtag   3840
 gaattgttgc cacatctgaa ttagctgttg atgctggagt ggtagcttta gatccgcctt   3900
 ggctaacatc agaaagctca tccttcaggc tggtatgaga acgtggttga cttaattcct   3960
 gaaatttcca ttgctcagat ccaggggtct ctcctccttt ctgagcatca ggtgtaagca   4020
 atccatctcc agcaggtaat gggaaaattc ctaatgatat agggcgttct tttctaattc   4080
 tactatgagc tgtggattct agttgatcac tccctgagag ctgatgaagt tttgttcttt   4140
 ctaaatgttc catataatta tggatcatct cagtgtgtct ttgatgtaat gcattatatt   4200
 ccttcttcag ttctgcttct ctttcttcaa gtatgctaat ctggtcagca tagtttttcg   4260
 ctttcagctc aagttgtctt gtttgagatt ctaaagattc cactcgggtc tgtaagtcct   4320
 ttttttcctg ttcttgagag tcttcaaatt caatgaattt ctcctcagcg tgcttgcgca   4380
 gcgccttctc tcgctcgtac tgggtgatga gctgctcgtt gtcgtcccgc agcagctcca   4440
 gctccacctg gtgctcctgg tcctgcgcga acaccgagtc caggttctcc agcacagcca   4500
 ccaccagcgg gatcagctct ttgaccacct cctcgtcata gcgcacgata agccgctcga   4560
 actcgcggta gatggagccg gccaggccgg acacccgctc cgacatcacg gccccggagc   4620
 cgccgggctc ctcctgatac accacaccgt cctccagctc catggttggc aagcggacgg   4680
 gcgggcggcc cggggcgtcg                                               4700



      <210> 1142
      <211> 1895
      <212> DNA
      <213> Homo sapiens


      <400> 1142
 atggatgggc tccaggccag tgcagggccg ttgaggcgcg ggcggccgaa gcgccggcgc     60
 aagccccagc cacacagcgg gtcggtcctg gccctgccct tgaggtccag gaagatacga    120
 aagcagctgc gaagtgttgt atcccgcatg gcagcgctga ggacgcagac gctgcctagc    180
 gagaactcgg aggaatcgag ggtggagtcg acggccgacg acctggggga cgcgctaccc    240
 gcccggcgag agccatacgg ccacctgggg cccgcagagc tgctggaggc ctcgcccgcc    300
 gcgcgctccc tgcagacccc gtcggcgcgc ctggtgcccg cttccgcgcc gcccgcgcgc    360
 ctggtggagg tgcccgccgc gccggtccgg gtggtggaga cctcggccct gctgtgcacc    420
 gcgcaacact tagcggccgt ccagtcgtcc ggggcccctg cgacggcgtc ggggccgcag    480
 gtggataaca cgggtgggga gccggcctgg gactccccgc tgcggcgcgt cttggccgag    540
 ctgaaccgca tccccagcag ccggcggcga gcggcccgcc tctttgagtg gctcatcgcg    600
 cccatgccgc cagatcactt ttaccggcgc ctatgggagc gcgaggcggt gctggtgcgg    660
 cggcaggacc acacctacta ccagggactt ttctctaccg ctgacctgga ttcgatgctg    720
 cgcaacgagg aggtgcagtt cggccagcat ttggacgccg ctcgctacat caacggacga    780
 cgcgagaccc tgaacccacc cggccgcgcg ctgcccgccg accgcgtggt ccctgtacca    840
 ggccggctgc tcgcttgcgt ctcctctgtc cgcaggcttt ctctactact gtgtggcagt    900
 ttttggctgt gcttcaagag cagtttggaa gcatggcagg ctccaacgtt tacctcacgc    960
 cccctaactc gcagggcttt gccccccact acgacgacat cgaggccttc gtgctgcagc   1020
 tggaaggtag gaaactctgg cgtgtatacc gaccccgagt cccaaccgag gaactggctc   1080
 tgacatccag ccccaacttc agtcaggacg acctcggtga gccggtgctg cagaccgtgc   1140
 tggaacctgg agatttgctg tattttcctc ggggcttcat tcaccaagct gaatgccagg   1200
 atggagtcca ctctctgcac ctcaccttgt ccacgtacca gcgcaatacc tggggtgact   1260
 tcttagaggc catactgcct ctggcagtgc aggctgcaat ggaagaaaat gtggagtttc   1320
 ggaggggtct gccccgagac ttcatggatt acatgggggc ccagcattca gattctaagg   1380
 atccgcgaag aaccgctttc atggagaagg tgcgggtctt ggttgcccgc ctgggacact   1440
 ttgctcctgt tgatgctgtg gccgaccagc gagccaaaga cttcattcac gattctctgc   1500
 cccctgtttt gactgatagg gagagggcac taagtgttta cgggcttcca attcgctggg   1560
 aggctggaga acctgtaaac gtgggggccc agttgacaac agaaacagaa gtccatatgc   1620
 ttcaggatgg gatagctcgg ctggtgggtg aggggggcca tttgtttctc tattacacag   1680
 tggaaaactc ccgtgtgtat catctggaag aacccaagtg cttggaaata tacccccagc   1740
 aagctgatgc catggaactg ttgcttggtt cttatccaga gtttgtgaga gtgggggacc   1800
 tgccctgtga cagtgtggag gaccagctgt ccttggcaac cacgttgtat gataaggggc   1860
 tgctgctcac taagatgcct ctagccctaa attag                              1895



      <210> 1143
      <211> 791
      <212> DNA
      <213> Homo sapiens


      <400> 1143
 tattgcaaga gaacactcag atcgagccaa gtgaacccaa aaaccaagaa gaaaagaaac     60
 tgtcccaggt gctaaatgag ttgcaagtat cacacgcaga gaccacattg gaactagaaa    120
 agaccaggga catgcttatt ctgcagcgca aaatcaacgt gtgttatcag gtgcaaggaa    180
 agatggtaca ggaaggggat ggataacagg aacgtgggaa ccactcacag gactgggaat    240
 gaagcaagac ctaagtttcc agggctgata ccaggaggaa ctggaggcaa tgatgacaaa    300
 agctgacaat gataatagag atcacaaaga aaagctggag aggttgactc gactactaga    360
 cctcaagaat aaccgtatca agcagctgga aggtatttta agaagccatg accttccaac    420
 atctgctcaa agatgttgct tatggcaccc gaccgttgtc gttatgtttg gaaacactgc    480
 cagcccatgg agatgaggat aaagtggata tttctctgct gcatcagggt gagaatcttt    540
 ttgaactgca catccaccag gccttcctga catctgccgc cctagctcag gctggagata    600
 cccaacctac cactttctgc acctattcct tctatgactt tgaaacccac tgtaccccat    660
 tatctgtggg gccacagccc ctctatgact tcacctccca gtatgtgatg gagacagatt    720
 cgcttttctt acactacctt caagaggctt cagcccggct tgacatacac caggccatgg    780
 ccagtgaaca c                                                         791



      <210> 1144
      <211> 634
      <212> DNA
      <213> Homo sapiens


      <400> 1144
 tccgcgattt ccggttcgac ccacgcgtcc ggatagctca ctctctggta cagtgatggc     60
 ggagattaat tttgtgaaga ggagaaggaa tattttgatg atagcacaga agaaaggttt    120
 tacaagcagt cttccatgtc tgaagatagt gatagcggtg acgacttctt cattgggaaa    180
 gtcagacgga cacgaaagaa ggaaagtagt tgtcattctt cagttaagga acaaaaacca    240
 ctagaaaaag tgtttcttaa agaagataca ggtgaaactc atggggatac aagaaatgac    300
 aaaatcaagc caagtacaga aaccagaaag ttagaatcag tgtttttcca ctctttatct    360
 ggatctaaaa gctctagaag aaatttcaaa gaacaggctc caaaaacaag atccctagat    420
 tttccacaga atgagcctca gatcaagaat cagtttaata agaagctatc aggaagactt    480
 gaaaatacaa aacagcaatt gcagctgcct cttcatcctt catgggaagc aagcagaagg    540
 cgaaaagaac agcaatctaa tattgctgtg tttcagggga aaaaaattac gtttgatgat    600
 tgattagtgc ctctttctgc aaacttttcc atct                                634



      <210> 1145
      <211> 737
      <212> DNA
      <213> Homo sapiens


      <400> 1145
 aggcatgact tcatctggat ccaggcctca cctatcagcg cttccttcct gggcagggct     60
 gaggattcac tcactgccca cggccggctg agcagggaca ggagaatgag aggcctccgc    120
 tggcgttaca ctcggctgcc cagccaggtg gaggacaccc tgtctgggga ggagggtaac    180
 gaagaggaag aggaggagga ggcagctcca gacccagctg ctgctcctga ggatcccacg    240
 gtgccccagc tgacagaagc cagccaggtt ttgagtgcct cagagattcg gcagctcagc    300
 tttcacttcc caccaagagt caccggccat ccctggagtc tggtcttctg cacgtcaagg    360
 gacggtttca gcctgcagag cctgtaccgg cggatggagg gctgcagcgg gccagtgctg    420
 ctggtgctca gggaccagga cgggcagata tttggagcct tctcctcctc ggctatccga    480
 ctcagcaaag gcttctatgg tactggcgag acattcctct tctccttctc cccacagctg    540
 aaggtcttta agtggactgg aagcaactct ttctttgtga agggagactt ggattcactg    600
 atgatgggca gtggcagtgg cggtttgggc tgtggttgga tggagacttg ttccgcgggg    660
 gaagctcccc ttgcccgacc ttcaacaacg aggttctggc ccggcaggaa gcaagttctg    720
 caatccagga gctggag                                                   737



      <210> 1146
      <211> 2255
      <212> DNA
      <213> Homo sapiens


      <400> 1146
 cagggactga tcagctgggt atttttctgc aggatatgca ctgataagca acatagcttg     60
 ggcatgtgga atttgtgcca gttccactct cccgtcacca tcaccccctg gaaggaggta    120
 aggaaagtcc tcccagagta aatgacattg aatctgagac accaagaaca tgtaggctgt    180
 agctcagcaa gatgagagga ggtgtccaga tgaaaggagt agtatacaca aatgcccaga    240
 ttcaggggaa acacaggccc acagatccca cacagcctca tttctaagaa aaatattttg    300
 ttctgaagga cgaaaatgac cttcaaagac cttgggatgg atgacttggg tatttactct    360
 tgcgatgtaa cagacactga tggaatagca tcaagctact taatagatga ggaagaattg    420
 aaacgtttac ttgctctcag ccatgaacac aagttcccaa ctgtcccagt taaatcagag    480
 ttggcagttg aaattttgga gaaaggccag gtccggtttt ggatgcaggc tgagaaactg    540
 tctggcaatg ccaaagtcaa ctacatattt aacgagaagg aaatttttga aggcccgaaa    600
 tataaaatgc atattgaccg aaacactggc atcatcgaaa tgttcatgga aaagctacag    660
 gatgaggatg agggaacgta cactttccag cttcaagatg gaaaagcaac taaccattct    720
 actgttgttc tcgttggaga tgttttcaaa aagctccaga aagaagctga attccagcgg    780
 caagaatgga tcaggaaaca aggtcctcac tttgttgagt atttgagctg ggaagtgact    840
 ggtgaatgta atgtactatt gaaatgcaag gtggcaaata ttaagaagga gactcatatt    900
 gtgtggtaca aagatgagag ggagatatca gtggatgaaa agcatgactt taaggatggt    960
 atatgtaccc tgcttataac agagttttcc aagaaagatg ctgggattta tgaagttatc   1020
 ctgaaagatg accgaggaaa agataagagc agactgaagc ttgtggatga agcctttaag   1080
 gaactgatga tggaagtatg caaaaaaata gctttgtctg ctacagacct gaaaatccag   1140
 agcacagccg agggcatcca actgtactct tttgtaactt actatgtgga ggatttgaaa   1200
 gttaactggt cccacaatgg gtccgccatt aggtactcag acagagttaa gaccggggtc   1260
 actggagagc agatctggct acaaatcaac gagcccaccc cgaatgacaa agggaagtat   1320
 gtcatggagc tctttgatgg caaaactgga catcagaaga cagtggatct ctctggacaa   1380
 gcatacgatg aggcttatgc tgaattccag aggttgaaac aagctgccat tgccgagaaa   1440
 aatcgtgccc gggtgttggg aggtctccca gacgtggtca ccatccagga ggggaaggcc   1500
 cttaatctca cttgcaacgt gtggggagac ccgcctccgg aggtgtcgtg gttgaagaac   1560
 gagaaggccc tggcctcaga cgaccactgc aacctcaagt tcgaggctgg gaggaccgcg   1620
 tacttcacca tcaacggcgt gagcaccgct gactcgggca aatacgggct ggttgtgaag   1680
 aacaagtatg gctcggagac cagcgacttc accgtcagcg tgttcatccc agaggaggag   1740
 gcgaggatgg ccgccttgga gtccctgaaa ggcggcaaga aggccaagtg accggaggtg   1800
 cgaggagagc cagccggcct gtgtgacttg ggtgtgaatg gtttgggtta aggatgagac   1860
 gtcttcatgc tttctcctcc ctattatttt ctggcttgag gggaaaataa tgtcaggtct   1920
 ttcactcata taaaaaagca ccaactaatg acactttaat tgtttttctt tatctacaaa   1980
 attatgtgtt aagaaaatac cattcatagc atgaagatta ggaaacagtt ttaaggagaa   2040
 gacttgaatg aagttggagg gacattgaat gatggtcaga gggcagacga atgtgtcgtg   2100
 gggcgaattg ggatttgctg cagctgtgaa gccatggccg tgtctcgtgt gttgttacag   2160
 aggtgatgtg cttttcgacg ggcgcctcgt ggcttggaac ctcctctgta tgaataaaca   2220
 gttttcacgt ctgtcctctt ccccgaaaaa aaaaa                              2255



      <210> 1147
      <211> 673
      <212> DNA
      <213> Homo sapiens


      <400> 1147
 caaccccaag accaagaagc acctgggcat tgccaaggtg gtctttgcca cggtccgggg     60
 agccaaggat gccgttcagc acttgcacag cacttccgtc atgggcaaca ttatccacgt    120
 ggagctggac accaaaggtg agcctggcag gggaggagcg tggggagacc tgtcagcccg    180
 accctttccc tccccaccct tcctgcagcg tggggaggac cccccctcac tcttccttgg    240
 gatccccccc cacaacctta tttcttagcc ccctcctgag ggtagagtcg cgtggagcta    300
 aatgtgttgt ctgttgctag gagacagtct gtaatttacc aaatgtgccg gtccttggcc    360
 accgcacccc tagggaccac ccggaggctt ccccaccgct gacacccccg cgggccccct    420
 ctctgagccc tggtggcttg ggtttagaca gtccccagtg ttgcctgtgt taggggagga    480
 gacagagttt gtttacttgt gggggactga ggaagtgcca ctaggatgcc ttgaaataca    540
 tcaagagaag gtctgaaaac tgaaaagaga gtcctctaag gatccagggt gtccccccac    600
 ctccttgctg acccttcccc tctggaagtg gcagccaatc tggggcccag gaatgttgtt    660
 tcattgataa ggg                                                       673



      <210> 1148
      <211> 1178
      <212> DNA
      <213> Homo sapiens


      <400> 1148
 tggcccgcgt ttccccggca acccgcggcc gccgccatgg acgcgctgtt gggcacaggg     60
 cctcgccggg ctcgcggctg cctgggcgcg gctggaccca cgtcttcagg tcgcgcggcg    120
 cggaccccgg cggcgccctg ggcgcgcttc tccgcctggc tggagtgtgt gtgcgtggtc    180
 accttcgacc tggagctggg ccaggcgctg gagctggtgt atccgaacga ctttcggctc    240
 acagacaagg agaaaagcag catctgctac ctgtcttttc ccgactcgca ctcaggctgc    300
 cttggagaca ctcagttcag cttccgcatg cgccagtgtg gagggcagag gagcccctgg    360
 catgccgacg acaggcacta caacagcagg gcccctgtgg cactgcagag ggagccggca    420
 cactactttg gctacgtgta cttcaggcag gtgaaggaca gctctgtgaa gaggggctac    480
 ttccagaagt ctttggtgct ggtgtcccgc ttgccctttg tccggctgtt ccaagcgctg    540
 ctaagcctca tcgcccccga gtactttgac aagctggcgc cctgcctgga agcagtgtgc    600
 agtgagatcg accagtggcc ggcgcctgcg cctgggcaga ccctgaacct acctgtcatg    660
 ggcgttgttg tccaggtgcg catcccatcc agggtggaca agtccgagtc cagtcctccg    720
 aagcaatttg accaagagaa cctgctgcca gccccagtgg ttcttgctag cgtccacgag    780
 ctggacctgt tcaggtgctt ccggcctgtg ctgactcata tgcagacact gtgggagctc    840
 atgctcctcg gggagcccct gctagtcctg gcaccctcgc ccgacgtgtc ctcggagatg    900
 gtgctggcct tgaccagctg cctgcagccc ctcaggttct gctgcgactt ccgtccctac    960
 ttcaccatcc atgacagcga gttcaaggag ttcaccacac gcacgcaggc cccaccaaac   1020
 gtggtcctgg gagtcacaaa ccctttcttt atcaaaacac tccagcactg gccccacatc   1080
 ctccgagtcg gggagcccaa gatgtcagga gacctgccta agcaagtcaa gctgaaaaag   1140
 cctttcaagg tttgaagacc ctgggacacc aagccagg                           1178



      <210> 1149
      <211> 524
      <212> DNA
      <213> Homo sapiens


      <400> 1149
 ggaattcccg ggtcgacgat ttcgtggcgg ccggcggcgg cggaggcagc agtaaggcct     60
 cctcctcgtc ggcctcttcg gcaggggctc tggagtcctc gttggatcga aaattccagt    120
 cggtaaccaa caccatggag tccattcaag gcttgtcgtc ttggtgtata gagaacaaaa    180
 aacaccacag tactatcgtc tatcattgga tgaagtggct ccggagatct gcatatcccc    240
 accgtttgaa tctcttttac cttgccaatg atgtcataca gaactgtaaa aggaaaaatg    300
 caatcatatt ccgtgaatca tttgctgatg tacttcctga agcagctgct ctagtgaagg    360
 atccatctgt ctctaagtct gtagaacgaa tctttaaaat ctgggaagat agaaatgtat    420
 acccagaaga aatgattgtg gcattgagag aagctttgag taccactttc aaaactcaga    480
 agcagctgaa agaaaatctg aacaaacaac cgaataagca gtgc                     524



      <210> 1150
      <211> 870
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(870)
      <223> n = a,t,c or g


      <400> 1150
 tttttttttt ttcacagcca catatatgtt tattctgcga gtccgtgtcc cacagtctga     60
 gactcttctt cccctcccct tcccgccccg tgaagtggcc cggggccgag ccccgcctcc    120
 atcttggctc agccaattcc cacccagttt ccaggagtct catttgcatt tccgggagca    180
 gctgtccaat gggaaggcag caccctgccc ccccccacaa gggggcggca ctcctggtgg    240
 atcgcaccac tcttgggatc cagggatggg gggaacgggc ttccactgag gtccgggtga    300
 caggagggtg gtcttccctc aaggcagggt tggagttcag tggaggaggg agttctggcc    360
 ttggaagagg cccagcagtc cgctgtctgg ggcgggctcc ttgatgagtt tctggatctc    420
 cttgaactgg gggtggacgg catcgcccac aagctgcaga atgagccctt cgctggtgga    480
 gaggaaggca ccactctgtc tcatgcgggc cagagccacc agccggtcca cctggctgcg    540
 tgaggagcag gcgtccacca ccacatggac ctgcagcccc cggtctagga ggtccagggt    600
 cgtgttctgt gggtagagag aggtcagggc caaccccgga taagaacggg ggtcctgggt    660
 aaggaattgg ggatggtgag tcagaattag gggcccagaa tggggaggag ggaggctcgg    720
 atcagaggaa ggggccccca ggtcaggagg ggatccaaga taggatgggg cccacaggtg    780
 aggagagagg gcccaggtca ggatgggggt cctgcaggca agtggaggtn nnnnnnnnng    840
 nagngaagac ggnatcaggn nnagncccct                                     870



      <210> 1151
      <211> 922
      <212> DNA
      <213> Homo sapiens


      <400> 1151
 tttttttttt tttgacttgc aacaggaaga acttttattg aaacaccacc atagagaaaa     60
 agccaaagaa atggtactat tctaaaaata acttgtctta attcattgga agaaaagcag    120
 aaaaataagg ggacccttat ttaggaaact agcttcattt tggtatttta atttgggggc    180
 cattctgtct cagaggctgg agttcaggaa gacaccctct gttcattctt gttgttgact    240
 ttggtggatt tctcttccac agtgtgaact ctggatgaga gaactttgcc acgaggatct    300
 atctcttcaa caactgtttt gacaatggtg gttttagatg aatcttttgt ttgatttcct    360
 gggcctccat agccttttga tttagaacag gagccatctt ctccatctat caggaggcag    420
 taggtctcaa tttctttttc caggtggacc ttgatgtcaa ggagctgctc atactcgagc    480
 ttctggccct cggtctcggt tctgacctgg tgcagctgct cctccagggc cccgatctga    540
 gcctggatct gtgccagctg tgcacagtag ttactctcgg tctctgtcaa ggagcactcc    600
 agggagtgtt tcgttgctaa gagggactga agttcaatct caagggtttg aagagtgcgt    660
 ttcatctcgg taagctcatt ccgggctgag gtggtggcgc cagcgtcgtc agagatctgc    720
 tgctgcagcg aggcgctctt ttcgttgaac caggcctccg cgtccctgcg gttctgctct    780
 gcgagggctt cgtactcagc tcgcatattg ttcagcagaa ccgtgaggtc taccccgggg    840
 gccgcgttca tctccacgtt cacgttgcct ccagccgcgc actgaagagc tttcatttcc    900
 tcctcatgat tcttcttgag ga                                             922



      <210> 1152
      <211> 1224
      <212> DNA
      <213> Homo sapiens


      <400> 1152
 tttttttcag atttaaaccg tctttatttc tacagcaaca tcttgaaaat agagagcagc     60
 cgcctcaccc gcaacagggg gagcccctcc tgccaccagg ggaccgtcgc cgcccctcgc    120
 gagaagaggg acgagggtgc cgaagggccg gcgagtgctt agtgttcttg gctctggggt    180
 ctggggaggc caggccactg agtctatggt ggagactcca gccggcacct cctgctggcc    240
 cgaacctagg gaagagggcc ctgctggaag gaataaataa gggatggagc tggagtgggc    300
 aggcccagcc tccagggctc aggctgagat gacaagggag aaggttaccc tgagattgaa    360
 cagaaaagac aggggctgtg ggagagacag gcgggacaag cagcaggccc atgcgcaggg    420
 ctggggtgag gggggtgtgc caggtgggcg ctctggtgac tggctgcccc ttcagcatta    480
 gcccaccagg gagcttcgtc gggagaggtc catggagctg gagctgagag tgcggctgtc    540
 agagagacct gtgcctccag gctgggtcgg ctcttccacg ctcttgttga ggaagttgag    600
 ggaactggcc cgcttcatcc tggggttagg gggctcctgg ggggtgcccc cctgcagctt    660
 ctttaccagc atctcactgc tgcgcctcag ggcatcccgg agtttcccaa aggacccgct    720
 gcgcctcaag gagccactgc catccccatt ccactcagct gtaggtccca cgtcctcgag    780
 gtcagactca gaccgaggcc cggcaccccc agccatgtct cggctgctgc ggcggtctcc    840
 ccgcctgcca ctgccatctt tcagcagttc taccaccttg gtctggcttg cggggtccaa    900
 accctgaggg aggggcaggg gcatcaggca gtgaatggac cacacccagg gccacacagg    960
 tgtctgccca ccccctcctg catggagccc cacctgcttg cggttacggc tggcacagtc   1020
 ctctagtgtg tgcgcggctt ccagcttgcc ctggcgccgg tatagggccc ccaagctgcg   1080
 cagggtggtg ttgactgtgg ggctgtggat gggacagtct caaactccat gttcccccag   1140
 acccagggcc catcctggca cccagcccac agtgggccct gaggaagcat ggacctccgg   1200
 ggtagccaga atccattcct tccc                                          1224



      <210> 1153
      <211> 654
      <212> DNA
      <213> Homo sapiens


      <400> 1153
 cgacccacgc gtccgctgtt ttcctgcgca ggagccgcag ggccgtaggc agccatggcg     60
 cccagccgga atggcatggt cttgaagccc cacttccaca aggactggca gcggcgcgtg    120
 gccacgtggt tcaaccagcc ggcccgtaag atccgcagac gtaaggcccg gcaagccaag    180
 gcgcgccgca tcgccccgcg ccccgcgtcg ggtcccatcc ggcccatcgt gcgctgcccc    240
 acggttcggt accacacgaa ggtgcgcgcc ggccgcggct tcagcctgga ggagctcagg    300
 gtggccggca ttcacaagaa ggtggcccgg accatcggca tttctgtgga tccgaggagg    360
 cggaacaagt ccacggagtc cctgcaggcc aacgtgcagc ggctgaagga gtaccgctcc    420
 aaactcatcc tcttccccag gaagccctcg gcccccaaga agggagacag ttctgctgaa    480
 gaactgaaac tggccaccca gctgaccgga ccggtcatgc ccgtccggaa cgtctataag    540
 aaggagaaag ctcgagtcat cactgaggaa gagaagaatt tcaaagcctt cgctagtctc    600
 gtaatgcccg tacaaagacc ggatcttcga catacggcac aaagagccag ggaa          654



      <210> 1154
      <211> 1346
      <212> DNA
      <213> Homo sapiens


      <400> 1154
 tttttttttt ttttaatgga taactgaaat gtatggtttt catttataaa gtataagtta     60
 tctttaataa cacacatgta caataaataa ttcatatatg aaaattctca tcagatagct    120
 tcatgctttg atcagtggaa gaagccacag caccagggaa atcagaaggc aatcttagta    180
 aatcttctac ctcttcttgc agggcttctg ctttttcatg caacaggcat ctttgctgat    240
 gaaacaattt gcttggcttg gcgatcttga taaatgatca attgtcctta cgaggcactt    300
 caggatttgc attagctaag tgcattagac ttttgtaacc tgcactggta taactgtttt    360
 tggctcggac cctctaaaac tccagtaact tccatgagag ggattaattc tgcctttaca    420
 cagtaagtca gcttcttggt aagttctacc aaaagggctc tgtaaaccca aaactcctca    480
 agctcctcac agaaatgtaa cacacaagat gagaatgagg cagttccagt gagaagattt    540
 tgtatatatc ctcgaggcat attaaatttt tcagatacag tccaaatgtt ggtctctttg    600
 agcaaggtat aaagaacaaa agacagatat agcctgttga caacgttctt gtccaccttc    660
 tttccgatgg cttggcctga tgctttcttc ccaataaagc tttcagagac tccaagaatg    720
 gcagctacat tttgttctgc tggactgagt tggctaaact gcctgaagta tatcatccaa    780
 tcagggttac actgtgaaac cagatcatag ggggttgtta ggtagattag atgaagaagg    840
 ctttcaagca caagtccttc aagacctttc ttcaagtctc tgtacagaat gtcacaataa    900
 gctaaatcta tagttccctt aaatgaagca cgtcccaact ttgtaatatg aaaattatat    960
 tggacctctt cttcagactt ataaatagtg tctttttgta ggagtccttt ttctgtcagg   1020
 tatctaagtg attcaacagt tatttcccag agactttttt ctttcaataa aaccttttgc   1080
 tgaacaccaa aaaatgtacc attcatgaaa tgatagatgt catcaagatt cgttgcaatc   1140
 ttcaaaccaa tcaaagagag aaataatgtt tggattccct tggtgaattc ctgaacaaga   1200
 tggctgtaac agttttccaa tggtttagtt attaactcca atacctgttg tttgtctttt   1260
 tcttgcaata tgaggatact ctccccaata gtatctattc cagcacgacc agccctcgtg   1320
 ccaagctggg cgtaataatg gtctca                                        1346



      <210> 1155
      <211> 1110
      <212> DNA
      <213> Homo sapiens


      <400> 1155
 ggaattccag gtaggtcatc cttgcggcct tgcggcatgg gcagtatccg ccgccatcct     60
 cttccgtgag gcgcgctgag acccggaccg gccctcctga gaggatgccg gtgcgggcgc    120
 ccgcggagag ggtagggagt ggtgggcgcg gcggcctcgg gggcggggtc ccggaaagcc    180
 gggctggcgg gggtacccgg gccgcccggc cgcgctaatc gtgagtcgcc cccaggaccc    240
 gtcgccatgg gccgtgtgat ccgtggacag aggaagggcg ccggtgtctg tgttccgcgc    300
 gcacgtgaag caccgtaaag gcgctgcgcg cctgcgcgcc gtggatttcg ctgagcggca    360
 cggctacatc aaagggcatc gtcaaggaca tcatccacga cccgggccgc ggcgcgcccc    420
 tcgccaaggt gggtcttccg ggattcgtat cggtttaaga agcggacgga gcttgttcat    480
 tgccgccgag gggcattcac acgggccagt tttgtgtatt gcggcaagaa ggcccagctc    540
 aacattggca atgtgctccc tgtgggcacc aatgcctgag ggtacaatcg tgtgcttgcc    600
 ttggaggaga agccttggag accgtggcaa gcctggcccg ggcatcaggg aactattgcc    660
 accgttatct cccacaaccc ttgagaccaa gaagaccccg tgtgaagctg cccttccggg    720
 tccaaagaag gttatctccc tcagccaaca agagcttgtg gttggtgttg gtggctggag    780
 ggtggcccga atgtgacaaa cccatctttg aaggctggct cgggccgtcc cccaaatata    840
 aaggcaaaag aggaactgct gggccacgag ttacgggggt gtgggccatg aatccttttg    900
 aagcattctt tttgaagggg ggaaaccccc cagcacatcg gcaaagccct ccacccatcc    960
 gcagagatgc ccctgctggc cgcaaagtgg gtctcattgc tgcccgccgg actggacgtc   1020
 tccggggaac caagactgtg caggagaaag agaactagtg ctgagggcct caataaagtt   1080
 tgtgtttatg ccaaaaaaaa aaaaaaaaaa                                    1110



      <210> 1156
      <211> 929
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(929)
      <223> n = a,t,c or g


      <400> 1156
 ttttggtttg acacttgtta gccagcattt agttcacaag catagtgaaa gtgaccttcc     60
 cacacctggg agagggatag aggagggaga gccagcccag tgtatgccat gggcttatcc    120
 gtggcagccc cagtgtgcaa ctatcaaaaa cagacatcaa aacagcatgg tgaatgcctg    180
 gcactcagca ttctcagttt actcttcagt ttggtggggt agctcctgga ctagatactg    240
 ctgcaaaaag aaaacaagca cgaagggaac ccaagatgat ttcttcgggc tgatacaacc    300
 tgttctgacc tgcaaaaatc ctaccttccc ccacctcccc accgtaatag tcatagtata    360
 agggttgtac agacgcctca ggagacctgc ctgattcctt tacatccttc tccctaacat    420
 ctagactatc tctagagctg tttcctagtc gtgaatgcgt gatggtcctt ctttgtccct    480
 gcaagtatga tccaacatgg cccagttcag aatcagaata tgtcttctgt gtcatggtgg    540
 catttggtcc atggtgggag aaagaaatca acttttccca gtggtggagt gaggacaggg    600
 gagggccggc cctctcagcc ttggatgtga tccatttgct gtagtcttcc accttggtgt    660
 acagaaacag gccagggcac gtctcaccac cgaagttcag gactcctctc agaacccaca    720
 gatcgaactg ctgtagctgg cacatcattg ggcttcctgg gtccccctgt gataaaagac    780
 agaaggcttc aagtcttaga aaaactagtt tttgttgtaa atctatcctt gtgcaatata    840
 ctgtttgttc tnnnnnnnnn nnnnnnnnnn nnnngggggg gggccgtttt aaaggaacaa    900
 attttacttc cgcgggcggg ggaggtttt                                      929



      <210> 1157
      <211> 1992
      <212> DNA
      <213> Homo sapiens


      <400> 1157
 aaatatactt acttagaact tcccttcatc gagaaagaga acaagcgcaa caacttcatc     60
 aacttcttgc attgaaagaa caggaacaca ggaaggaact tgaaacaagg gagtttttta    120
 ctgatgctga cttccaggat gccttagcta aagaaatagc caaagaagag aaaaagcatg    180
 agcaaatgat aaaagaatac caagagaaaa ttgacgtgtt aagccagcag tatatggatt    240
 tagaaaatga attccgtatt gctttaactg ttgaagccag aagatttcaa gatgttaaag    300
 atggttttga aaatgttgca actgagttag caaagagcaa acatgctctt atttgggctc    360
 aacgaaaaga aaatgagtct tcctctttaa ttaaagatct gacctgtatg gtaaaggaac    420
 aaaaaacaaa actggcagaa gtttctaaat tgaaacaaga aacagcagca aatttacaga    480
 atcaaatcaa cacccttgaa attttaattg aagatgacaa gcagaagagt attcaaatag    540
 aacttctcaa gcacgaaaaa gtccagctta tttctgagct agcagccaag gaatcactaa    600
 tatttggttt aaggacagaa agaaaagtat ggggacatga gctggcacaa caaggatctt    660
 ctctagccca aaatcgtgga aaattggagg ctcaaattga gagtttatct agagagaatg    720
 aatgtctgcg aaagacaaat gaaagtgata gtgatgcatt aagaataaag tgcaaaatca    780
 tagacgacca aactgaaact attagaaaat taaaagattg tttacaagaa aaagatgaac    840
 acatcaaaag attacaagaa aagatcacag aaatagaaaa atgcactcaa gaacaacttg    900
 atgaaaaatc ttcacaactg gatgaggtac ttgagaagtt ggaaaggcac aatgaaagaa    960
 aagaaaaact aaaacaacag ttgaaaggaa aggaagtaga acttgaagaa atcagaaaag   1020
 cttacagtac actgaatcgg aagtggcatg ataaaggaga acttctatgt catcttgaaa   1080
 cacaagtaaa agaagtgaaa gaaaaatttg aaaacaagga aaagaaactt aaagcggaaa   1140
 gagacaaaag tattgaacta caaaagaatg caatggaaaa acttcatagt atggatgatg   1200
 cctttaaaag acaagttgat gcaattgttg aagctcatca agctgaaata gcacagctgg   1260
 ccaatgaaaa gcagaagtgt attgattctg caaatttaaa ggtccatcaa attgaaaaag   1320
 aaatgcgtga acttttggaa gaaacatgca agaacataaa aacaatggaa gcaaaaatta   1380
 agcaacttgc ttttgcttta aatgaaattc agcaagatat gtgatggttc tgagaatgaa   1440
 tttaattgaa atagaccagc agacctattg taaaaatgat taaatattgt aatagtagta   1500
 actgctatga ctttgaaatg tctctttcta tacatttcat tatgaatata tttttaaaga   1560
 cttttgatca agtattaatt gtataggttt tttataataa attgttgaca attttgtcta   1620
 ttagaaaaaa ctatcataac tagacttaca atatttttct tgtttctgta ctatacgttg   1680
 tttggtaatt acacatttgc ctacaaattt gtgaatgaaa agattagtat tttcaccata   1740
 tgaggtaaaa cattttaatc attgttatct tattgtgatg atgaagaact aattatattt   1800
 gttatttaat tgatgtagct caattctttt aaagtactta tgtagccaaa aagcatttga   1860
 aatctgtatg ataaaagatg tggcattctt aagaaagtat atgtagccat ctccacatca   1920
 ctcattatga ccccttcttt tataatgctt atatcttttc attaaagatt acatttaagg   1980
 ttttataaaa aa                                                       1992



      <210> 1158
      <211> 364
      <212> DNA
      <213> Homo sapiens


      <400> 1158
 ctgaccctgc ggcccccaag cctggcagcc ccctacgccc cagtgcagag ttggcaacac     60
 cagccagaga aactcatctt cgagtcctgt ggttatgaag ccaattatct gggctccatg    120
 ctgatcaaag atctgcgagg gacagaatcc acgcaagacg cctgtgccaa gatgcggaaa    180
 tctacggagc acatgaagaa gatccccacc atcatcctgt ccatcacata caaaggtgtc    240
 aagttcatcg atgcctccaa caagaacgtc attgcagagc acgagatccg gaacatttcc    300
 tgtgcggccc aggacccgga ggacctctgt acctttgcct acatcaccaa gggacctggc    360
 gacc                                                                 364



      <210> 1159
      <211> 364
      <212> DNA
      <213> Homo sapiens


      <400> 1159
 ctgaccctgc ggcccccaag cctggcagcc ccctacgccc cagtgcagag ttggcaacac     60
 cagccagaga aactcatctt cgagtcctgt ggttatgaag ccaattatct gggctccatg    120
 ctgatcaaag atctgcgagg gacagaatcc acgcaagacg cctgtgccaa gatgcggaaa    180
 tctacggagc acatgaagaa gatccccacc atcatcctgt ccatcacata caaaggtgtc    240
 aagttcatcg atgcctccaa caagaacgtc attgcagagc acgagatccg gaacatttcc    300
 tgtgcggccc aggacccgga ggacctctgt acctttgcct acatcaccaa gggacctggc    360
 gacc                                                                 364



      <210> 1160
      <211> 1499
      <212> DNA
      <213> Homo sapiens


      <400> 1160
 cgaccaaact aaagaaggag caggagaatc tgttgaagca gcggtgggag ctagagaggc     60
 tggaggaaga gcgaaagcag atggaagcct tccggcagaa ggcagagctg gggcgtttct    120
 tgagacatca gtataacgct caactcagca gacgcacaca gcagatccaa gaggagctgg    180
 aggcagacag gcggatcctg caggccctcc tcgagaagga ggacgagagc cagcgcctcc    240
 acctggccag gcgggagcag gtcatggccg atgtggcctg gatgaagcag gccattgagg    300
 agcagctgca gctggagcgg gcgcgggagg cagagctgca gatgctgctg agggaggagg    360
 ccaaggagat gtgggaaaag agagaggcag agtgggcccg agagcgcagc gcacgggaca    420
 gactgatgag cgaggttctg acagggagac aacagcaaat acaagagaag attgagcaga    480
 accgacgggc acaagaggaa tccctgaaac acagggagca acttattcga aatcttgagg    540
 aggtgagaga gttggctcgt cgcgagaaag aggagagtga aaagctgaaa tcggccagga    600
 agcaggagct ggaagcccag gttgcagagc gccggctgca ggcatgggaa gcagaccagc    660
 aggaggagga ggaagaggag gaggcccggc gggtcgagca gctctcagat gccctgctgc    720
 agcaggaggc ggagactatg gctgagcagg gctaccggcc taagccttac ggacatccaa    780
 aaattgcttg gaactgactt catgggtacc ataagtacag agaacaaggg atgctgaggc    840
 ttctgatccc agccgccagg cagttttaca gggctctgtt aacagtaagt gcccggggca    900
 ctgtcagatg gctcagcagt gcctgctcag gttcatcatt gaaacatccc agtgtttggc    960
 cagacattaa ggtgtcgtga gagtcccttt catgcctttc ttacccaagc aagggtcttt   1020
 gatgggcacg tgtttacagc gctgctgcat tagtcttgta atatattaac agtcacatca   1080
 actgaaggtc aatactaaga gccacaggtt gtacctgtga tggggcgtgt ggtttcctgt   1140
 tgtctcacct ttaattgtca acctccagtg ttgactctag aaatatgagg aaagcttttc   1200
 agtttttaaa attgccattt aaatttagtc tattaaaaac aaacctagag gtcttggtgc   1260
 agttgatttc agagtttatt aatttagtgg tcccaaaagt attacatctt ttatattctg   1320
 gaagaaaaga actgtgaaca aattagaacc ccggaacact ctgacgtcca tggacgcatt   1380
 ccagaaaagt ggcaagagat gagtctttcc tcctccagga agcattttgg tagaatttcc   1440
 atagagcatt gtctgtgagt gactgatccc aacatgtatg ttactaagcc ccaaaacga    1499



      <210> 1161
      <211> 3458
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(3458)
      <223> n = a,t,c or g


      <400> 1161
 ggtttacacg tacctccgcc tcatcgtgga ccaccatggg actgcccagc tccaggccct     60
 gcgacagaag gaagtagact tctgcatctc actgcttcgg gaacggttca tggaatgtct    120
 gatgattggt cgggatctcg taagactact tcagaatgtt gctaggatac cagaatttga    180
 actgctttgg aaagatatta tccataatcc tcaggccttg agtcctcagt tcacaggtat    240
 cctacagctt cttcagtcaa gaacatcccg aaaattccta gcatgtcgtc taaccccgga    300
 catggagact aaactcctct tcatgacatc ccgggtgcga tttggtcaac aaaagcgata    360
 ccaagattgg ttccagcgcc agtacctgtc aactccagat agtcagtctc tgcgctgtga    420
 cctcattcgc tacatctgtg gggtagtcca cccttctaat gaagtactga gttcagatat    480
 cttgccccgg tgggccatca ttggttggct cctgacaacg tgcacgtcaa atgtcgctgc    540
 ctccaatgcc aagctggctt tgttttatga ctggctgttc tttagtccag acaaggatag    600
 cattatgaac atagaaccag ccatcctggt catgcaccac tccatgaagc cccacccagc    660
 catcactgcc acactcctgg acttcatgtg ccgcatcatt cccaacttct atccaccatt    720
 ggagggccac gtgcggcagg gtgtcttttc ctccctcaac cacattgtgg agaaacgggt    780
 cttggcgtgt aaaaagtatt ggctctacct cagactgctg ggcatatgtc ttcttggctc    840
 ttagaggaat ttctctcctg ccatcgtatt acaaagacac ctagctcccc tgtttgacaa    900
 ccctaagttg gataaggagc tgcgggcaat gctgagagag aagtttcctg agttctgcag    960
 ctcaccctcc ccacctgtgg aagtcaaaat tgaggagcca gtttccatgg agatggacaa   1020
 ccatatgtcg gataaggatg agagttgcta tgacaatgca gaggcagcct tcagtgacga   1080
 tgaagaggat ctcaacagca aaggaaagaa gagggagttt cgcttccacc ctatcaagga   1140
 gacagttgtg gaggagccag ttgatatcac cccttacctt gaccagttgg atgagtccct   1200
 gagggacaaa gtactccagc tacagaaggg gagtgatacg gaggcccagt gtgaggtcat   1260
 gcaggaaatt gtggaccagg tcctggagga agactttgac tcggagcagc tgtctgtcct   1320
 tgcttcctgc ctacaggagc tcttcaaggc ccactttcga ggggaggtcc tgcctgagga   1380
 gattactgag gagtccctgg aggagtctgt aggaaagcct ctgtacctaa tatttaggaa   1440
 cctatgtcag atgcaggaag acaacagcag cttctctcta cttctagacc ttctctccga   1500
 gctatatcag aagcagccca agattggcta ccacctgctc tactacctga gggccagcaa   1560
 agccgccgca gggaagatga acctgtacga gtcatttgcc caggctaccc agctgggcga   1620
 tctgcacacc tgcctgatga tggacatgaa ggcctgccag gaggacgatg tgcggctcct   1680
 gtgccacctc acgccctcca tctacacaga gtttccagat gaaaccttga ggagcggaga   1740
 gctgctgaac atgatcgtgg ctgttattga ctctgcacag ctccaggagc tggtctgcca   1800
 cgtgatgatg ggtaacctgg ttatgtttcg aaaagactca gttctcaaca tactcattca   1860
 gagcctagac tgggagacct ttgagcagta ttgtgcctgg cagctctttc tggcccacaa   1920
 tattcccctg gagaccataa tccccatcct gcagcacctc aaatacaagg agcacccaga   1980
 ggccctgtcc tgcctactgc ttcaactccg aagagaaaag cccagcgagg agatggtgaa   2040
 gatggtgctg agccggccct gccatcctga cgaccagttc accaccagca tcctgcggca   2100
 ctggtgcatg aaacatgacg agctgctggc cgagcacatc aagtccctgc tcatcaagaa   2160
 caacagcctg cctcgcaaga gacagagcct gaggagctct agcagcaagc tggcccagct   2220
 gactctggag cagatcctgg agcacttgga caatctgcgg ctcaacctga ccaacaccaa   2280
 gcagaacttt tttagccaga cgccaattct ccaggcgctg cagcatgtcc aagcgagctg   2340
 tgacgaagcc cacaagatga aattcagtga tctcttctcc ctggcggagg aatatgagga   2400
 ctcttccacc aagccaccca agagccggcg aaaagcagct ctgtccagcc ctcgaagtcg   2460
 aaagaatgcc acacagcccc ccaatgccga aggaaggagt cggggttcca gcagtgtttt   2520
 caggaaggag ggaaggacac ggaaaccgaa gccttaccaa gcgggaaacg gaaaagggtc   2580
 ctctgcagtg ggctctgaca gtgactgagg ccctgcattc cccatcccac ccccggctgg   2640
 actgccctct ccttcttggt gattcaaagg ttaatagagg ctgaggagat tgcaggggaa   2700
 acacccttgc tgcatcccca agctcccccg gtggaaggag gagctttctc ctctggctga   2760
 gtttgagaag ctgccatgca cgccctagcc ccttccctcc tcctggggcc tccagcccct   2820
 cacactgctg ttcccagtga tatttgggat ctgactgaag ccagaggctc tgtaaaatca   2880
 gaccatagtg gaagtcctca gccccctggc cccttccgca atctcctccc ccagtctccc   2940
 aaagagccat ttcaacagag aagggaaatg acaaaggggc agctggccag ataagctagg   3000
 atgagagcag agactcagtg tgtgggtgtc ccttcctgct tcccccttca ggtcttggtt   3060
 tgttctgaag ggacgtttta tagtcactat ccacatgcca gtgtgaaatg ggcatctatg   3120
 acgtggtcag ggtgtccatt cctaatcatg gggggngggg gggnccccaa agaatgccac   3180
 cnaagcattc agaaaggagt ctgaaagggt ggccacagcc ccacgatggt gtgccctggg   3240
 aggcttaggt tggtcttgag gttgggcacc tcaatctaca ccagagcccc aggggagtcc   3300
 cagagggcaa gttttcacag aattgtcaaa tgatcccatt tccttgagtc tgtttttttt   3360
 ttttgttttt ttttgttttt tttttggcag agataatcgt gttcttaaaa ttgttttttt   3420
 aaatgacaat aaaacaagcc agaatgtcaa aaaaaaaa                           3458



      <210> 1162
      <211> 3458
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(3458)
      <223> n = a,t,c or g


      <400> 1162
 ggtttacacg tacctccgcc tcatcgtgga ccaccatggg actgcccagc tccaggccct     60
 gcgacagaag gaagtagact tctgcatctc actgcttcgg gaacggttca tggaatgtct    120
 gatgattggt cgggatctcg taagactact tcagaatgtt gctaggatac cagaatttga    180
 actgctttgg aaagatatta tccataatcc tcaggccttg agtcctcagt tcacaggtat    240
 cctacagctt cttcagtcaa gaacatcccg aaaattccta gcatgtcgtc taaccccgga    300
 catggagact aaactcctct tcatgacatc ccgggtgcga tttggtcaac aaaagcgata    360
 ccaagattgg ttccagcgcc agtacctgtc aactccagat agtcagtctc tgcgctgtga    420
 cctcattcgc tacatctgtg gggtagtcca cccttctaat gaagtactga gttcagatat    480
 cttgccccgg tgggccatca ttggttggct cctgacaacg tgcacgtcaa atgtcgctgc    540
 ctccaatgcc aagctggctt tgttttatga ctggctgttc tttagtccag acaaggatag    600
 cattatgaac atagaaccag ccatcctggt catgcaccac tccatgaagc cccacccagc    660
 catcactgcc acactcctgg acttcatgtg ccgcatcatt cccaacttct atccaccatt    720
 ggagggccac gtgcggcagg gtgtcttttc ctccctcaac cacattgtgg agaaacgggt    780
 cttggcgtgt aaaaagtatt ggctctacct cagactgctg ggcatatgtc ttcttggctc    840
 ttagaggaat ttctctcctg ccatcgtatt acaaagacac ctagctcccc tgtttgacaa    900
 ccctaagttg gataaggagc tgcgggcaat gctgagagag aagtttcctg agttctgcag    960
 ctcaccctcc ccacctgtgg aagtcaaaat tgaggagcca gtttccatgg agatggacaa   1020
 ccatatgtcg gataaggatg agagttgcta tgacaatgca gaggcagcct tcagtgacga   1080
 tgaagaggat ctcaacagca aaggaaagaa gagggagttt cgcttccacc ctatcaagga   1140
 gacagttgtg gaggagccag ttgatatcac cccttacctt gaccagttgg atgagtccct   1200
 gagggacaaa gtactccagc tacagaaggg gagtgatacg gaggcccagt gtgaggtcat   1260
 gcaggaaatt gtggaccagg tcctggagga agactttgac tcggagcagc tgtctgtcct   1320
 tgcttcctgc ctacaggagc tcttcaaggc ccactttcga ggggaggtcc tgcctgagga   1380
 gattactgag gagtccctgg aggagtctgt aggaaagcct ctgtacctaa tatttaggaa   1440
 cctatgtcag atgcaggaag acaacagcag cttctctcta cttctagacc ttctctccga   1500
 gctatatcag aagcagccca agattggcta ccacctgctc tactacctga gggccagcaa   1560
 agccgccgca gggaagatga acctgtacga gtcatttgcc caggctaccc agctgggcga   1620
 tctgcacacc tgcctgatga tggacatgaa ggcctgccag gaggacgatg tgcggctcct   1680
 gtgccacctc acgccctcca tctacacaga gtttccagat gaaaccttga ggagcggaga   1740
 gctgctgaac atgatcgtgg ctgttattga ctctgcacag ctccaggagc tggtctgcca   1800
 cgtgatgatg ggtaacctgg ttatgtttcg aaaagactca gttctcaaca tactcattca   1860
 gagcctagac tgggagacct ttgagcagta ttgtgcctgg cagctctttc tggcccacaa   1920
 tattcccctg gagaccataa tccccatcct gcagcacctc aaatacaagg agcacccaga   1980
 ggccctgtcc tgcctactgc ttcaactccg aagagaaaag cccagcgagg agatggtgaa   2040
 gatggtgctg agccggccct gccatcctga cgaccagttc accaccagca tcctgcggca   2100
 ctggtgcatg aaacatgacg agctgctggc cgagcacatc aagtccctgc tcatcaagaa   2160
 caacagcctg cctcgcaaga gacagagcct gaggagctct agcagcaagc tggcccagct   2220
 gactctggag cagatcctgg agcacttgga caatctgcgg ctcaacctga ccaacaccaa   2280
 gcagaacttt tttagccaga cgccaattct ccaggcgctg cagcatgtcc aagcgagctg   2340
 tgacgaagcc cacaagatga aattcagtga tctcttctcc ctggcggagg aatatgagga   2400
 ctcttccacc aagccaccca agagccggcg aaaagcagct ctgtccagcc ctcgaagtcg   2460
 aaagaatgcc acacagcccc ccaatgccga aggaaggagt cggggttcca gcagtgtttt   2520
 caggaaggag ggaaggacac ggaaaccgaa gccttaccaa gcgggaaacg gaaaagggtc   2580
 ctctgcagtg ggctctgaca gtgactgagg ccctgcattc cccatcccac ccccggctgg   2640
 actgccctct ccttcttggt gattcaaagg ttaatagagg ctgaggagat tgcaggggaa   2700
 acacccttgc tgcatcccca agctcccccg gtggaaggag gagctttctc ctctggctga   2760
 gtttgagaag ctgccatgca cgccctagcc ccttccctcc tcctggggcc tccagcccct   2820
 cacactgctg ttcccagtga tatttgggat ctgactgaag ccagaggctc tgtaaaatca   2880
 gaccatagtg gaagtcctca gccccctggc cccttccgca atctcctccc ccagtctccc   2940
 aaagagccat ttcaacagag aagggaaatg acaaaggggc agctggccag ataagctagg   3000
 atgagagcag agactcagtg tgtgggtgtc ccttcctgct tcccccttca ggtcttggtt   3060
 tgttctgaag ggacgtttta tagtcactat ccacatgcca gtgtgaaatg ggcatctatg   3120
 acgtggtcag ggtgtccatt cctaatcatg gggggngggg gggnccccaa agaatgccac   3180
 cnaagcattc agaaaggagt ctgaaagggt ggccacagcc ccacgatggt gtgccctggg   3240
 aggcttaggt tggtcttgag gttgggcacc tcaatctaca ccagagcccc aggggagtcc   3300
 cagagggcaa gttttcacag aattgtcaaa tgatcccatt tccttgagtc tgtttttttt   3360
 ttttgttttt ttttgttttt tttttggcag agataatcgt gttcttaaaa ttgttttttt   3420
 aaatgacaat aaaacaagcc agaatgtcaa aaaaaaaa                           3458



      <210> 1163
      <211> 504
      <212> DNA
      <213> Homo sapiens


      <400> 1163
 tttttttttt tttttttcag cttcggaatg tgacaattta tttggcgttg atacaatatt     60
 gaagagcagc agaacaaacg tacaagacag agtaatcggc acagacccac ccctcccccg    120
 gaaccgccga atccagaatg gagcccaaac ccacaccccc aactaagcgt cttctccaca    180
 gggggagggg cagggtggac tgggggacct gccccccatg ctggggcggc acctccgttt    240
 tccatctcct gccaacccca ctcttttccc atctttgacc actggaggca aagtttagcc    300
 agctgggagc tggatggttg aaccacatac aaaggcaaca acacttcatt ttaaaaatga    360
 gagaaaaaag agacagtgcc cctccccaaa tatagagcta tatatgtata ttttatatat    420
 atagaattca ttcgtgcaca attcattaaa tgaacgtctc aaaaattaaa aaaattataa    480
 gatacgtatt tctttaggcc tttg                                           504



      <210> 1164
      <211> 1662
      <212> DNA
      <213> Homo sapiens


      <400> 1164
 cgctggtgtt gcggcgctgg cgacagtcgg ggttgcgagc ggcccggggc cggggcggcc     60
 agggccgctg caggacgaga ccctgggtgt ggcgtccgtg ccctcgcagt ggagggccgt    120
 ccagggcatc cgcggggaga cgaaaagttg ccagacggcc agcattgcca ctgccagtgc    180
 atccgcccag gccaggaatc atgtggacgc ccaggtgcag acggaggccc ccgtgcctgt    240
 cagcgtgcag cccccgtccc agtatgacat acccaggctc gcagcctttc ttcggagagt    300
 ggaggccatg gtcatccgag agctgaacaa gaattggcag agccacgcgt ttgatggctt    360
 cgaggtgaac tggaccgagc agcagcagat ggtgtcttgt ctgtataccc tgggctaccc    420
 gccagcccaa gcgcagggtc tgcatgtgac cagcatctcc tggaactcca ctggctctgt    480
 ggtggcctgt gcctacggcc ggctggacca tggggactgg agcacgctta agtccttcgt    540
 gtgtgcctgg aacctggacc ggcgagacct gcgtccccag caaccgtcgg ccgtggtgga    600
 ggtccccagc gctgtcctgt gtctggcctt ccaccccacg cagccctccc acgtcgcagg    660
 agggctgtac agtggtgagg tgttggtgtg ggacctgagc cgtcttgagg acccgctgct    720
 gtggcgcaca ggcctgacgg atgacaccca cacagaccct gtgtcccagg tggtgtggct    780
 gcccgagcct gggcacagcc accgcttcca ggtgctgagt gtggccaccg acgggaaggt    840
 gctactctgg cagggcatcg gggtaggcca gctgcagctc acagagggct tcgccctggt    900
 catgcagcag ctgccacgga gcaccaagct caagaagcat ccccgcgggg agaccgaggt    960
 gggcgccacg gcagtggcct tctccagctt tgaccctagg ctgttcattc tgggcacgga   1020
 aggcggcttc ccgctcaagt gttccctggc agctggagag gcagccctca cgcggatgcc   1080
 cagctccgtg cccctgcggg ccccagcaca gtttaccttc tccccccacg gcggtcccat   1140
 ctactctgtg agctgttccc ccttccacag gaatctcttc ctgagcgctg ggactgacgg   1200
 gcatgtccac ctgtactcca tgctgcaggc ccctcccttg acttcgctgc agctctccct   1260
 caagtatctg tttgctgtgc gctggtcccc agtgcggccc ttggtttttg cagctgcctc   1320
 tgggaaaggt gacgtgcagc tgtttgatct ccagaaaagc tcccagaaac ccacagtttt   1380
 gatcaagcaa acccaggatg aaagccctgt ctactgtctg gagttcaaca gccagcagac   1440
 tcagctcttg gctgcgggcg atgcccaggg cacagtgaag gtgtggcagc tgagcacaga   1500
 gttcacggaa caagggcccc gggaagctga ggacctggac tgcctggcag cagaggtggc   1560
 ggcctgaggg gtcccgggag gcgggtgcaa gccttcgctg tgccgagcct tgtgtttctg   1620
 acgcaagcca aatgaagaaa agcaaagctt ataaaaaaaa aa                      1662



      <210> 1165
      <211> 717
      <212> DNA
      <213> Homo sapiens


      <400> 1165
 tacggctgcg agaagacgac agaagggtac ggctgcgaga agacgacaga agggtacggc     60
 tgcgagaaga cgacagaagg gtacggctgc gagaagacga cagaaggggc ttccgccacg    120
 gccgtctctg gagagcagca gccatggccc tacgctaccc tatggccgtg ggcctcaaca    180
 agggccacaa agtgaccaag aacgtgagca agcccaggca cagccgacgc cgcgggcgtc    240
 tgaccaaaca caccaagttc gtgcgggaca tgattcggga ggtgtgtggc tttgccccgt    300
 acgagcggcg cgccatggag ttactgaagg tctccaagga caaacgggcc ctcaaattta    360
 tcaagaaaag ggtggggacg cacatccgcg ccaagaggaa gcgggaggag ctgagcaacg    420
 tactggccgc catgaggaaa gctgctgcca agaaagactg agcccctccc ctgccctctc    480
 cctgaaataa agaacagctt gacagaagcc ctggctctcc tgctgtccgt gggtgggtgt    540
 gggtgtgtcg ggggcccgca gtcccctgtc tggtgcccgc tttgagccac accctctccg    600
 ggtgctgcct ggtcgtgaat caaaagccgt ggcccgccca cccttcccgg ggcagcaggt    660
 gaggaagccg ccgtactgca aatgacttta atcattaaat agcttatatg ccccaaa       717



      <210> 1166
      <211> 574
      <212> DNA
      <213> Homo sapiens


      <400> 1166
 acgagggctc cagtcaggcc aatacgctcc gctcacggaa ggaaaacaga aataacttgc     60
 tggcttgtct ggagtcacat gtacttaggt gacaatttac agaaagtcat ctctgcagct    120
 tgatgggcga caaccctttt caaccaaaaa gtaattcaaa aatggcagaa ctgtttatgg    180
 aatgtgaaga agaggagctg gaaccatggc agaagaaagt aaaagaagtt gaggatgacg    240
 atgatgatga gccaatcttt gttggcgaga tatcaagttc aaaaccagca atttcaaata    300
 ttttgaacag agttaacccc agctcatatt caaggggact aaagaatggt gcactcagtc    360
 gaggtattac tgctgcattc aagcctacaa gtcaacacta cacgaatcca acatcaaatc    420
 cagtgcctgc ctcaccaata aattttcatc ctgagtctag atcttcagat agttctgtta    480
 ttggtcagcc tttttctaaa cctgtaagtg tttctaaaac tatacggcca gctcagggat    540
 ccattggatg ttgtttatca atatcaacag tacc                                574



      <210> 1167
      <211> 3575
      <212> DNA
      <213> Homo sapiens


      <400> 1167
 atgtcgaggc gcaagcaggc gaaaccccag cacatcaact cggaggagga ccagggcgag     60
 cagcagccgc agcagcagac cccggagttt gcagatgcgg ccccagcggc gcccgcggcg    120
 ggggagctgg gtgctccagt gaaccaccca gggaatgacg aggtggcgag tgaggatgaa    180
 gccacagtaa agcggcttcg tcgggaggag acgcacgtct gtgagaaatg ctgtgcggag    240
 ttcttcagca tctctgagtt cctggaacat aagaaaaatt gcactaaaaa tccacctgtc    300
 ctcatcatga atgacagcga ggggcctgtg ccttcagaag acttctccgg agctgtactg    360
 agccaccagc ccaccagtcc cggcagtaag gactgtcaca gggagaatgg cggcagctca    420
 gaggacatga aggagaagcc ggatgcggag tctgtggtgt acctaaagac agagacagcc    480
 ctgccaccca ccccccagga cataagctat ttagccaaag gcaaagtggc caacactaat    540
 gtgaccttgc aggcactacg gggcaccaag gtggcggtga atcagcggag cgcggatgca    600
 ctccctgccc ccgtgcctgg tgccaacagc atcccgtggg tcctcgagca gatcttgtgt    660
 ctgcagcagc agcagctaca gcagatccag ctcaccgagc agatccgcat ccaggtgaac    720
 atgtgggcct cccacgccct ccactcaagc ggggcagggg ccgacactct gaagaccttg    780
 ggcagccaca tgtctcagca ggtttctgca gctgtggctt tgctcagcca gaaagctgga    840
 agccaaggtc tgtctctgga tgccttgaaa caagccaagc tacctcacgc caacatccct    900
 tctgccacca gctccctgtc cccagggctg gcacccttca ctctgaagcc ggatgggacc    960
 cgggtgctcc cgaacgtcat gtcccgcctc ccgagcgctt tgcttcctca ggccccgggc   1020
 tcggtgctct tccagagccc tttctccact gtggcgctag acacatccaa gaaagggaag   1080
 gggaagccac cgaacatctc cgcggtggat gtcaaaccca aagacgaggc ggccctctac   1140
 aagcacaagt gtaagtactg tagcaaggtt tttgggactg atagctcctt gcagatccac   1200
 ctccgctccc acactggaga gagacccttc gtgtgctctg tctgtggtca tcgcttcacc   1260
 accaagggca acctcaaggt gcactttcac cgacatcccc aggtgaaggc aaacccccag   1320
 ctgtttgccg agttccagga caaagtggcg gccggcaatg gcatccccta tgcactctct   1380
 gtacctgacc ccatagatga accgagtctt tctttagaca gcaaacctgt ccttgtaacc   1440
 acctctgtag ggctacctca gaatctttct tcggggacta atcccaagga cctcacgggt   1500
 ggctccttgc ccggtgacct gcagcctggg ccttctccag aaagtgaggg tggacccaca   1560
 ctccctgggg tgggaccaaa ctataattcc ccaagggctg gtggcttcca agggagtggg   1620
 acccctgagc cagggtcaga gaccctgaaa ttgcagcagt tggtggagaa cattgacaag   1680
 gccaccactg atcccaacga atgtctcatt tgccaccgag tcttaagctg tcagagctcc   1740
 ctcaagatgc attatcgcac ccacaccggg gagagaccgt tccagtgtaa gatctgtggc   1800
 cgagcctttt ctaccaaagg taacctgaag acacaccttg gggttcaccg aaccaacaca   1860
 tccattaaga cgcagcattc gtgccccatc tgccagaaga agttcactaa tgccgtgatg   1920
 ctgcagcaac atattcggat gcacatgggc ggtcagattc ccaacacgcc cctgccagag   1980
 aatccctgtg actttacggg ttctgagcca atgaccgtgg gtgagaacgg cagcaccggc   2040
 gctatctgcc atgatgatgt catcgaaagc atcgatgtag aggaagtcag ctcccaggag   2100
 gctcccagca gctcctccaa ggtccccacg cctcttccca gcatccactc ggcatcaccc   2160
 acgctagggt ttgccatgat ggcttcctta gatgccccag ggaaagcggg tcctgcccct   2220
 tttaacctgc agcgccaggg cagcagagaa aacgggtccg tggagagcga tggcttgacc   2280
 aacgactcat cctcgctgat gggagaccag gagtatcaga gccgaagccc agatatcctg   2340
 gaaaccacat ccttccaggc actctccccg gccaatagtc aagccgaaag catcaagtca   2400
 aagtctcccg atgctgggag caaagcagag agctccgaga acagccgcac tgagatggaa   2460
 ggtcggagca gcctcccttc cacgtttatc cgagccccgc cgacctatgt caaggttgaa   2520
 gttcctggca catttgtggg accctcgaca ttgtccccag ggatgacccc tttgttagca   2580
 gcccagccac gccgacaggc caagcaacat ggctgcacac ggtgtgggaa gaacttctcg   2640
 tctgctagcg ctcttcagat ccacgagcgg actcacactg gagagaagcc ttttgtgtgc   2700
 aacatttgtg ggcgagcttt taccaccaaa ggcaacttaa aggttcacta catgacacac   2760
 ggggcgaaca ataactcagc ccgccgtgga aggaagttgg ccatcgagaa caccatggct   2820
 ctgttaggta cggacggaaa aagagtctca gaaatctttc ccaaggaaat cctggcccct   2880
 tcagtgaatg tggaccctgt tgtgtggaac cagtacacca gcatgctcaa tggcggtctg   2940
 gccgtgaaga ccaatgagat ctctgtgatc cagagtgggg taggttccta ccctcccggt   3000
 ttccttgggg gccacctccg ttgtgaataa cgccactgtc tccaagatgg atggctccca   3060
 gtcgggtatc agtgcagatg tggaaaaacc aagtgctact gacggcgttc ccaaacacca   3120
 gtttcctcac ttcctggaag aaaacaagat tgcggtcagc taagggagaa cttgcgtgga   3180
 aggagcaatg cagacacagt gaaatctcta gaatctgctt tgttttgtaa gaactcatct   3240
 cctcctgttt tctttttctt actgatatgc aaatgatgtt tactacgttg gttgtgacca   3300
 caacctcagg caagtgctac aatcacgatt gttgctatgc tgctttgcaa aaagttgaaa   3360
 aaataaaaaa aaaatgcata ccaaaacaaa tacagactct ttttttttga gatggagtct   3420
 cgctctatca cccaggctgg agtgcagtgg catgatctcg gttcactgca acctccccat   3480
 tctgggttca agtgattctc ctgccttagc ctccagagta gctgggatta caggcaggtg   3540
 ccaccacgcc cggctaattt tgaattttga gtaga                              3575



      <210> 1168
      <211> 1540
      <212> DNA
      <213> Homo sapiens


      <400> 1168
 tttttttttt ttcatatttc aaatagttta attttaaaaa tattctattc agtgctaaaa     60
 tatgtcttca ctcactgttg cccatttcca ttttcttaaa cttttttgaa acaaaaaata    120
 aaatcacaaa gttcaattca acatgcagat ttcaaagaaa agggagcttt ctagaaactg    180
 agctgaaggg gtactgtggg ggatgggtac tgttgtcaga acctcaaatt cttgctgggg    240
 cagtttgtga caagaggcag ggatgctgga atgacaggta gaggtgagaa caaagctgcg    300
 tgtgtgcaga tgtgtgtgct gagggcaggg gatggggacg gcggccacaa agggctgtca    360
 gcagctaggg tgcccgtgag aggtaggacc acctcaggca tgggcagagc tggcaggaca    420
 gcaagaaatc tagacggact ctctgccctt gtgtggagaa aagcccttcc cttccctcca    480
 atgtctctac ccagtcctcc aacagcagcc tacagggccc ccagtcctag gggaaagtcc    540
 gggagtctac agtctccgtt caagttcaag taacctgagg cacgctctct tctagaaggt    600
 gccttccaca tctctctctt ctcgcagaag ctgccagcag ctccgtccag agattctgga    660
 gcagagactg ctgcctggag gtcacagatg aatcttgggg tggccgatgc tccagccaac    720
 ttggggtgca aaaaagacat gagcgctcct cttctcggga gcaagtagac acaggtgcca    780
 gggtcaggaa gatgatgcta cagccccaag tcctacgcca gccttccagc ccggaaggct    840
 catgtgtgca ggctcttgac cccagtgctt gcccttaccc cagcaacgcg gcgcggccag    900
 aaccagaatg caataaatag aggcagggcc aggaggcgga gggccgggat ggtgctagct    960
 ttctgacgcc gtctgcggca ctgtgggttg gtccacacag aagcgcttca ggggcggggc   1020
 acctgagtct tcctcttcct caacgacctg tgtctctagt ggaactggtt cttccttggt   1080
 gagggtagga ggttcatcag caacttccga ggagggcagg gagggctcct ccaggatctc   1140
 ctggcccagc gttgggggct gggagtcatc cgtgcggaag tcggaggtgt gtgctgggct   1200
 cagggactca ctctgctggg ggctggggct tgagttggtg ctgctgtcca ccttaagctg   1260
 atagacgtca gacacggaac tctggttgct gttttcgtcc tggaattcaa gaaggagaga   1320
 ggaattggct gaggcatcag aaggaaagcc attaggttct cgggctgctg aactgttcga   1380
 ttttgacttt tctttctcct tgctgtctgt cacaggaacc cacttaaata tcctcaggga   1440
 cgtgtcaccc acagtcaccc acttcttctc cccaacttca acgcctgaat acgcagagcg   1500
 ctcagcctgg cgaactgaca ccactccagg gctactcgct                         1540



      <210> 1169
      <211> 1732
      <212> DNA
      <213> Homo sapiens


      <400> 1169
 tttttttttt tttgcgaaag aacagaagag tataatgttc aacatgcagg gaaaaaaata     60
 acaatacata tttcagaaat aggagcagct tcagtgcagg cagtatcatg gcagccactc    120
 cacgggagga acgggatcct ctgccaacct tgtcagccac tccaactaag cagctgctgc    180
 accaggtgtg ttgctgctgt ctttctaagg gttcaagaac atgggctctg gggtcatatg    240
 gcctgcgttc acattccagc tccattcata gcctgcatga cctttagcac atgtcttggc    300
 ttctctgcct caatttcccc atctcatgga cctgctggcc aaggacgacc agaatggcga    360
 ggcggaggcc ttcaaggcag agatcaagaa gaccgacgtg aaagaggaga agaggaagaa    420
 ggagctgaac gaaatcttga aaagcacagt gagcagcaac gacaagaaaa ccaaaggccg    480
 gacgggctgg ccgcagcacg tctgggccct ggagctcaag cagtgaggag gaggagaagg    540
 aggaggagga gagcgcgagt gagcaggggc caaggcgcca gatgcagacc caggactccg    600
 gaaaagccgt ccgcgctccg ctctgaggac tccttgcatt tggaatcatc cggtttattt    660
 atgtgcaatt tccttcccct ctctttgacc ccctttgagg catctgctcc ccgtctcccc    720
 ctccaaaaaa aaagtggata tttgaagaaa agcattccat attttaatac gaagaggaca    780
 ctcccgtgtg gtaagggatc ccgtcgtctc atagattctg tgtgcgtgaa tgttccctct    840
 tggctgtgta gacaccagcg ttgccccccg ccaacctact caaccccttc cagataaaga    900
 cagtgggcac tagtgcgttt gtgaagtgta tctttaatac ttggcctttg gatataaata    960
 ttcctgggta ttataaagtt ttatttcaaa gcagaaaaca gggccgctaa catttccgtt   1020
 ggggtcggta tctagtgcta tccattcatc tgtggtcgtt ccctctttga agatgtttcc   1080
 aacagccact tgttttgtgc acttccgtcc tctaaaacta aatggaattt aattaatatt   1140
 gaaggtgtaa acgttgtaag tattcaataa accactgtgt tttttttttt acaaaaacct   1200
 taatttttta atggctgata cctcaaaaga gttttgaaaa caaagctgtt atacttgttt   1260
 tcgtaatatt taaaatattc agaagtaaac taaattatca tgattgcctc taactttatt   1320
 ttaaagactc agtgggttcc aaccagttca ccctgacctg cggcctacgc agaagggagg   1380
 gagggtgctc ttaaagagga aggtgtcctt gttacaaaat cctgcaaatg ggtctggggg   1440
 tttgtcgggt gtgggtgtct ccttcccctc ttccccccag ctgggggaac ggctggagta   1500
 ggtctctaga aggaagatct gggctggaga acccagtccg gcagttcgct cagaaggtgt   1560
 aaaggtgctc ttggctttcc tgaagtcaat cagaagccat ttcttgaggc cgtcagtttt   1620
 tgtttggaga gtgtttctgg tggaggagtt gtgaggagaa ccccggcatt attgctgcaa   1680
 cgggaactag tctggggtgt ttaattcaaa ctatggggct ttcatccaaa aa           1732



      <210> 1170
      <211> 803
      <212> DNA
      <213> Homo sapiens


      <400> 1170
 tttttttttt ttgccaatgg aacaggacat catttaattg cctctagggt cctcctggga     60
 gagggactgc ggggcctttg gcagagctct ggctgatgga accaacagag gtgcccatca    120
 gccagtgcca ggcaggatgg cggccccaat gcttggctgg gggcagccag catttggggc    180
 tgttgcttaa gacaatttct gagactaatg ggtaaggaat gttgccttta gatggaggag    240
 aggggactac atttagagag gagggaggag aagtggcctg cattggggga gggactctaa    300
 ggttaggtta ggaatgacag ggagttggtc aaaaggtcct tcatggccag gtgaaggctg    360
 gggggagtgt ggtgatggag tccagcaggg gaactctgga caggcttgac tcaagccagc    420
 ttcaggaact cctgcagcgt gttttgttcc acagcctcca cgaagagctc atagtcccca    480
 cagtactggt ccccgttgac aatctggggt ggggtggcct tggggttgcc tgccaaggct    540
 cgcatctcat ccctcagggc gttgtcctgg gagatgtcca ctagctggta ttggatgcgc    600
 ttcccatcca ggattcgggt cacctcgctc tgctgggact tgatttcgcg ggagccggtg    660
 accgacgtgc tgtagacgcg caggccgctc atgctggggg tagacagacg ggccggcggg    720
 cagagggcgg cggtagcggc agctgcactg ccgggagacg acgccgccgc cgtgctcggg    780
 agcggtttcc ttcctgcacg aaa                                            803



      <210> 1171
      <211> 1842
      <212> DNA
      <213> Homo sapiens


      <400> 1171
 aagtacaaaa taatatttta ataacatagg aacatgaaca tgaaaacaat gtaaacaggt     60
 tagaattttt ggatatgata cctaccaaac gtgatttgga accgtaccgc aactgggtaa    120
 aatttctatg gcaaaaggat taaccaaggc atatcatagg aaatccactt tgcccaatat    180
 aagcagttct cagcacatac tcaaatgcac acaaacatga aaatcggaaa taaaggaatg    240
 ttaaaaaaat aacttaggca gacacaaata aaaccacccc actagtgtat gaatgatgcc    300
 acgtttctta tgatcttaat tacatttaag gatttaaaaa atgccactga tctcacagtt    360
 tacaatatcc aaatcttcaa acctgctgga agaagtccca cagcacagcc tggaaattcg    420
 catccgttgc attctctcgt gcagttacct gcttatgggc tgtaccttct gccttgatat    480
 gtagtcagtt cttcctgaag gatggaagct ctcttttgca gaaaattaac ctgtgatttt    540
 agggaggaaa tggtgtcttc aagttcttgt cttagggatg ctggcatcaa tcctttcaat    600
 tttgtttcat attcttgtcg tatgtaagtt atctgttcct gtgactccaa ttctttgtgt    660
 tgtaattttt tctctgcaca tcgcacctga ttagaacggt tttctaattc atcttgtaaa    720
 accttgattg cttggtcatt atctctaatc agctgcttct tctcatcttc aaacttttgt    780
 ctaacatcct ggagccgcct ttctgcagca agctgctgct ggctgttctc ttctttcaga    840
 gaggaaatgg ttgtctgaag ttctgctatg atctgtgaag atttggcaag cttctgagtg    900
 tattccttct caatctgctt cagcttgctg ttggcctttt ccagtgtcat ctctgtctca    960
 gcagcatgag tctttttcag ctctattttc atcttttctg attcagcctt cagtttattg   1020
 acgacaatct catgttccct tgtagccctt tgcttttcct cttcacgaag aagaccaagc   1080
 tctaccagct gctgtttccg ctgtgagttc acattgatca attcttctct caacttgtga   1140
 acctgggcct ccatgtcggc aataacctgt gcatctcgtt tcttgaactc ctgaatttga   1200
 ttttcgtgct ccatattggc agcgcgaagc tgtttttcca ggttttcaat ttcccgttca   1260
 tggtctcgga ctaggctatc cttctctgcg ttatgctgct gtaataggtg cgtcttctcc   1320
 tgttcatgct ccagcttcag ctctactatc tgttgttcat accgctgtct gatgtcctcc   1380
 agttgccata aaaactcctt tgattgtttc tcacgaagag atttggatct agttagatct   1440
 gcctccactt tttccatttc aaagcttcct caaatttatg aattttcttt tgagtatctt   1500
 cttttccttt atcaagttca ctctgcaagt catgagcctt tttttcatag atgtgtttta   1560
 gatgactttt ctccatctga aacttatttt cttgatccct tagttgttgc tttctttgaa   1620
 gttctgattc ctgtaactgc tgttttaatt gacagacatt ctgctctaat tcttcaatca   1680
 tactagatgc cttagaagct gaaagagcat gttcttgttt tagaaggttt atatcagcat   1740
 catatttggt ttgtaacagt ttcatgtttt gctcataatc atttacaaga tggtccttct   1800
 ctttatgcag tgtgttacgc cttgccttta cttcttgtaa tt                      1842



      <210> 1172
      <211> 1371
      <212> DNA
      <213> Homo sapiens


      <400> 1172
 tttttttttt ttctgggaga acaatggctt tattcagatg ttggtgcctc tgcccctctg     60
 gtgcccccga tccccacaag gggccgcgag gcgggcaggt cacagcaggt tgaagtcccc    120
 tttgtgctgt tccagccact ggtccagcgt cagggccttg gggttgagtc tcagggtcag    180
 ctcgatgtca cggtcgggtc tcagggcata gaaacggaac atgttggcca ggtcccgggc    240
 accgggaaag ccaagctttt cgtagtcctc aggagtcatc ttggcatcgt gcacgacctt    300
 gcgggtgtgc ttggtgagca gggcagcgta ctcctcggcc gtgtgcctgc aagtgctcag    360
 cccgatgttc tggccgacgt atttttctgg catcttcaaa aggctgagca ccacaggacc    420
 caggtcagac acggacatgc catccatggg aacgtcacct gtgggcaagc tcagcaagta    480
 gctctttccg tctggggctt tctggggcaa gaagtgggag aggaggttct caaaatagca    540
 gggcagccgc acactggtca tgggaacgcc aatgtcccgg aaatattcct ccacctcccc    600
 tttgccgtca aagtgcgcgg cggccaatct ccctgccgtc agcttcttga tgttctccag    660
 gccgctgtag accacatagt ggaggcccag gcgcctggcc agatcagcga gcagcttccc    720
 ctgcttgacc tcctgctcct ggctgcagct ctcccagtaa ttggtcacga tgaaggtggc    780
 gtaagcccca ttcagggcca gctccatgat gacctggtca tcttggtctc cctgcactac    840
 ttctgcacct tgcagcctca gctcctttgc tgccttcttc ctagggtttc gggtcaccac    900
 tcgaaccttg aatgtcccat cttccaggag tgtgcgggcc acggagccac cctgggcacc    960
 tgtgcctccg aaaaccacca ccagtttctt gtccaccatg aggacgagaa tgggacgaat   1020
 ccggtccaga gatctggcag agcgccgctc acggaagccc agcgtcggag gacccctggc   1080
 tgcagccgcc aatcccgacg tgtcggccga aacccctcct ccggcgcagt tggctcctcc   1140
 tggatcccgc gggactcggc gtcgtttccg ggtttgcccg ccccaggcac gtgcacagtg   1200
 agtttgtgta aatccagtta gaccaaaatg agcgaggtgg agagcctctt aaccggatgc   1260
 tacgggtgat gacccgctga gcagagcctg agcctgcaac ctccagagat ctggggaaag   1320
 ccacatactc cgcttcccgc ccccctcgtg ccaagcaggg cgtaagcagg t            1371



      <210> 1173
      <211> 449
      <212> DNA
      <213> Homo sapiens


      <400> 1173
 agacactgct cagcaaccta gaagaagcca agaagaagaa agaggatgcc ctaaatgaga     60
 ccagggaatc atagacaaag ctgaaggagc tcccaggagt gtgcaatgag accatgatgg    120
 ccctctggga agagtgtaag ccctgcctga aacagacctg catgaagatc tacgcacgcg    180
 tctgcataag tggctcaggc ctggttggcc gccagcttga ggagttcctg aaccagagct    240
 cgcccttcta cttctggatg aatggagacc gcatcgactc cctgctggag aacgaccggc    300
 agcagacgca catgctggat gtcatgcagg accacttcag ccgcgcgttc agcatcatag    360
 acgagctttt tccaggacag gttcttcacc cgggagcccc aggataccta ccactacctg    420
 cccttcagcc tgccccaccg gaggcctca                                      449



      <210> 1174
      <211> 476
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(476)
      <223> n = a,t,c or g


      <400> 1174
 gtggcgacgg tggcggacac ttggggtctg gacgcaacgg cggcgggagc atgaacgccc     60
 ctccagcctt cgagtcgttc ttgctcttcg agggcgagaa gatcaccatt aacaaggaca    120
 ccaaggtacc caatgcctgt ttattcacca tgaacaaaga agaccacaca ctgggaaaca    180
 tcattaaatc acaactccta aaagacccgc aagtgctatt tgctggctac aaagtccccc    240
 accccttgga gcacaagatc atcatccgag tgcagaccac gccggactac agcccccagg    300
 aagcctttac caacgccatc accgacctca tcagcgagct gtccctgctg gaggagcgct    360
 tccgggtgag ggcggggcct ggaggggcag acggngtggg ctggacactg gcccgtgtgc    420
 ccaggcctgg gacagccctg gcctggttct ttggaggtcc tcaaggagag gcggcg        476



      <210> 1175
      <211> 1441
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1441)
      <223> n = a,t,c or g


      <400> 1175
 tttttttttt ttaatttcac tccttcatga ctgtcacatg gacaaaatga aactaaactt     60
 aaatcataac taaaaaaacc accaactata tttttgaaga tttttctaat tcttgccact    120
 caaaggacaa cattttccac accggtttgt atgttatcct tttggtcatt gtcttctgaa    180
 ccaatgaaat gttgattctc caagggattt gagttttcgt ggcacacgtc acctattttc    240
 tcctgctgac ttgggctttt gaataagtgt ttcttttggt gcattccaag ggcagcagct    300
 gttttgcaaa ttttggggca ctggaagcag gcatagccct tcccattatg ctcccgaata    360
 tgcctctgct cgtgattcct tttggtggag agatacaaaa atctctgaaa gcagaactga    420
 cagtggtaac gcttttctcc agtatggatt ctttcatgga ttttgagggt ctcattcaag    480
 gtgaatgcct tgttgcaata ctgacagacg aactccttca agcccaggtg gatgcgttca    540
 tgtttctgta agtttccttg caccgaaaag caccgtccgc aggtcttgca ctggtatggc    600
 ttctccccgg tgtgacatct catgtgcatt ttgagtgtgg aagggctctg gaactgcttg    660
 gcgcagagct cgcaggcata tggccgagaa gtaagatgtc ggtggggcct tccttggttt    720
 ccagccccca ctgctttgtc tccatcacag agttcacact gcagcttggg catctcttta    780
 gtttcttctt cctcaaaggg tttatcctga ggagccttcc ccacggcgca atccagttct    840
 gctgggtatt tacatttatg gctcgggctc ctgtttccgt gctccttcct ccagttgact    900
 ttcctcattt ttttcaactg tctggatttc tttttgggtt tgtagttgta gtaagggcgc    960
 cacggtttgt cagtggaatc ctggtcactt gcgtcatcga acacttcact catctccatg   1020
 cactcggatt ggcaaagacc gagtgggctg tctccactgg gttatgggtc attcccctgt   1080
 ggcaaaggct cctcctgcat ctgatacttg ggtcttctcc ctcttttata aaacaattta   1140
 gatcatagaa tgtgcctttt cacaatggct tcgtttccaa ttttcactgt tatttggcaa   1200
 aggggtgcaa cattactatt tgtggaggtt cccggcagag caggttttgc aatgtaggtt   1260
 tcaattttgc tggtttcttc agcaatattt gtggttttgc tcagtgatcc tccaggatca   1320
 gcaacatagt ttgactcaac cggtatttct cccctggtat gtgatgtagt tttctttttc   1380
 tccttagtgc ttttgggtct gaacttccnc gcnnattgct aatgaactcg aangagcccc   1440
 a                                                                   1441



      <210> 1176
      <211> 5798
      <212> DNA
      <213> Homo sapiens


      <400> 1176
 gaaacttcat ggccacagcc ccaggccctg ctggcattgc catgggcagc gtgggcagcc     60
 tgttggaacg gcaggacttc tcccctgaag agctgggggc ggcacttgcc gggtctcggg    120
 gctcccgcca gcctgatggg ctcctccgga agggcttggg ccagcgtgag ttcctcagct    180
 acctgcacct ccccaagaag gacagcaaga gcaccaagaa caccaagcgg gcccctcgga    240
 acgagcctgc cgactatgcc accctctact accgggaaca ttctcgcgcg ggtgacttca    300
 gcaagacctc gctgccagaa cggggtcgct ttgacaagtg ccgcattcgc ccctcagtgt    360
 tcaagcctac ggcgggcaac gggaaaggct tcctatccat gcaaagcctg gcgtcccaca    420
 aaggccagaa gctgtggcgc agcaatggca gcctgcacac gctggcctgc cacccgcccc    480
 tgagccccgg gccccgggcc agccaggccc gggcacagct gctgcacgcc ctcagcctag    540
 atgagggcgg ccctgagccc gagcccagcc tgtccgactc ctccagtggg ggtagttttg    600
 gtcgcagtcc tggtactggc cctagcccct tcagctcctc ccttggccac cttaaccacc    660
 tcgggggctc cctggaccgg gcctctcaag gacccaagga ggctgggcca ccagctgtgc    720
 tgagctgcct gcccgagcca ccacccccct acgagttctc ctgctcctct gccgaggaaa    780
 tgggagccgt gctgcccgag acctgtgagg agctcaagag gggccttggc gatgaggacg    840
 gctccaaccc cttcacgcag gtgctggagg agcgccagcg gctgtggctg gctgagctga    900
 agcgcctgta tgtggagcgg ctgcacgagg tgacccagaa ggctgagcgc agcgagcgca    960
 acctccagct gcagctgttt atggctcagc aggagcagcg gcgcctgcgc aaggagctgc   1020
 gggctcagca gggcctggct ccggagcctc gggcccccgg caccctccca gaggctgacc   1080
 ccagtgcacg accagaggag gaagcccgat gggaggtgtg ccagaagaca gcagagatta   1140
 gcctcttgaa gcagcagctg cgtgaagccc aggcggaact ggcccacaag ctggcggaga   1200
 tcttcagtct gaagacacaa cttcggggca gccgggcaca agcccaggct caggacgcag   1260
 agctggtccg gctgcgcgag gctgtgcgca gcctgcagga gcaggcccct cgggaggaag   1320
 ccccaggcag ctgtgagact gatgactgca agagcagggg cctgctaggg gaggcaggag   1380
 gcagcgaggc cagagacagt gctgagcagc tgcgggctga gctgctgcag gagcgacttc   1440
 ggggccagga gcaggcgctg cgctttgagc aggagcggcg gacttggcag gaggagaagg   1500
 agcgcgtgct gcgctaccag cgggagatcc agggagggta catggacatg taccgccgca   1560
 accaggcact ggagcaggaa ctgcgggcac tgcgggagcc ccccacaccc tggagtcccc   1620
 ggctcgagtc ctccaagatc tgaggccagc agagcgagct gacagcagca acactgtcag   1680
 aaggtgccct gagacggccg gctcagcctt cccttgcact ggttggggtg gaacctgcag   1740
 aggccagccc ggggctgggg aggcgcaagg agaggaggga tccagtgggg ccgtgggctg   1800
 ggtagggtgc cttggcagga gccaggacaa ggccctcctg gcagaggagc acctaggcag   1860
 ggcccagccc tgcttcctgg agtggatgtg gcccagagaa ggaggctggg ggatcaccag   1920
 ccccaaggtc ccgaagggca ggtcagaggg agagaggctg gagacctggg ctggggcctt   1980
 cctccaggga aggaggctgg ggtgggaaca ctggcctccc ccagaataaa accatgtttt   2040
 ctaccagagg ctcagaatac gctgagcctg tgaccagagg atgatggatg gtcgggattg   2100
 aggctgttga cctgggcagt agctcctccc atggccagtg gtcagtggga gggtgtgccc   2160
 tgcgcctgtc tgcataccca ctgggcatgt gtgttgggag cagaggagtc ctactccttg   2220
 cctcagcccc acacggttcc ttagctgccg tgtgggctga aattcctttc tttagcacca   2280
 gtggagtttt cagaaggaac aacaccaggg aatgccaaaa aaacaaaggg caagtcaacc   2340
 aaggcatttt gagaacatga aatgtcttct tggtgggaag gctgggcccc aggagtatcc   2400
 acaggctcag gccatgcccc tccccgcacc cacctcctgt ctccctccct ccctccatag   2460
 gagtgggggg cccctagaag tgctctgcct cattccctgt tcgtaggaag gtgcaggaga   2520
 ggaggtgggc aagcttatgg gtttcttggt aaagagcctt taccacagca aggaatggga   2580
 acatttcccc atcagcaacg gggctctagg gcattattaa gtaggggtga aatatgattg   2640
 atttgcattc tggaaagctc tcccaggagg aagcattccc caccccacct tgcctctgtc   2700
 ctgcgctggg ctccaggacg gtcagtcctc ccagatccct gctctcagct aaggctggtc   2760
 cctaaaaccc acacctgcct ttggtctctc agaggcctgg cttgccctct gggcctttgc   2820
 tcccccgctg ggtgcccggc ctggaacaca ggttctgtct ggctgtgtga gtggcgtctc   2880
 tcccttcctt tgagggaagc tcagctttct tacgcgctca tcgttggacg ggctgccatg   2940
 cattgcgtgc ttactgggcg ccaggtgctg tgctgggccc ttgtgagtgt gggggcacag   3000
 gctgaattag atgagctcct gccgcagggg gccctgcaca ctgatgtcag ctcaccagtc   3060
 tcttccctga cagggcagct cagggaactt ctgagaagtt atctgcagag agccccccct   3120
 cactcccttt ggctaccctg gccgtgcctg gcagcccctc aggccccaca ggtgggtcct   3180
 ggttgtgaag tggagttagt gcacatggat gtcaggggac gggtgtgagg catgagctgg   3240
 gggggccccc tttttcaggg cagagaatga ggcgtgtgca ctgtctgctg tggggatggt   3300
 gtgtttatgg ccatgtaagt ggcaggtgtg tgtaaagatg tgcttgtggg tggtgggtgt   3360
 gtctgagggg gtgtgtttgg gagcctggcc tccaaaagcc agtgtctggg ttggagacag   3420
 tgcaggcccc ttcttggccc caccctctac cccattcctt cctgtcagcc ccagtctgtc   3480
 ttggcactgg ccaggcttgg gtggagcctg tgtcccagac agatccccta ggcctatctg   3540
 agacccatgc aggcccacac ctgagctcct gtctgcctga ggagggaaag ggggagtggc   3600
 caggtcaggc aggccagtcg tctacacacc cccttggtac ccattcccat ttcacaaact   3660
 cctccaaacc ccaaacccca aacggaaatc tctgggacaa tggctcctcc agagggcccc   3720
 tcagagccag gtgctggcca gatgccttga tcacagcctc catggccagg ggcctgtcaa   3780
 gccaggggcc cacacacctg gtgccagggc ccacctcggt ataccagctc ggcagaacag   3840
 ttccccaccc agcgattagg gagctgggct ggccagtaca gccagtgggg agtgggtggg   3900
 aggcaccaaa acttggcagc tgtgccagaa accaaagcca ggcccagatg tagggggagg   3960
 gcacgagagc tgaacctgag cctggggcgt ctcggagctg gatccccgtc agctcatcca   4020
 ggctggacaa accagttcct gggtccccca gccggctggg tggctctggg gccaaccgac   4080
 cacaggtgtc actgatcaca ggtgtcaccg tagtggctac cacctcaggg cagcccctcc   4140
 ctccagctgg cggggcctca gcttcccagc tgccctggct taaccttccc tgcagcccct   4200
 ccccaacagg cttggtccgg gcagcctgct ctgcggaagg tggcagcctc ctggtgctgg   4260
 gctccctgcc tctggggcct ccagtccttc actcagtgtc atcccttcca gcagctccct   4320
 gggcctcttg gtccatccct tcaggcttct gacacactag tggcctcgag tcactgatag   4380
 tggtgcctcc tccttacctt ggcaagccct tgtagccctc tgagccctca tcctgcaggc   4440
 agagcccctc agtgctctga gaaacctgcc ctgaactcac cgcctcccct gcctgggcac   4500
 tccctcctcc ctgcgcccac agcccccatg ccaatctccg tcagctcttt ctgtgctgct   4560
 gtaattgttg gtttgcctgt ctcctttgag ctgtgggcat tgccggggta gggtggtgtc   4620
 ttcaccacag ctccagaagg cactggtggg atgtggagtc aggagcaacc agagaccccc   4680
 caatactaga atgggtttga gcttggggtg gggtggatgg ggaagactta ctctgaatgt   4740
 tcgttcacca tccgtgggca ccaggtctgt gccaagcaca gggactccag gggcagctgc   4800
 cattcgttcc agtgatgtat ttggggcctt ctcaggtgag gaagccaagg tggccaaggc   4860
 cctcggtccc ctgccctgat agggcttacc tgtgggtggg ggagggagac cacacatgtc   4920
 aaaggtagtg aaggccgctc caaatagtga ctggggccag gcaggcggaa aagagaacag   4980
 aagagaatcc agaagtgttc agacagaact agggacaaca gaggggcctc catggtggca   5040
 tgggtcagca gagcatggag caggcagagg aagcctatct gtggggctgg gtacatttct   5100
 ctgagactca cggaatgtaa gtgttgaggt ttctgcaaag agggcgcagg ccctgcagtg   5160
 acggttcaga tattgataac ccatccccct tggcaggtgg gggcttaggc atccatattg   5220
 gattcagaaa agaaaaagaa tgatgcttct tgcaacaaaa acaaaagtga ttatgtcacg   5280
 agaggagagg ctggagggcc atgggagttc ccagctggct cactcatccg tccaggaggt   5340
 gggtctcatg gtttcatttt gctttgggct tacttagagt tttggcaaat gcagagttat   5400
 gtaacgaacc caacaatgaa gatacagttc tgtcaccccc ccagcattct cctgtggccc   5460
 tctagtccac cccccgcccc accccagccc ctggcaacca ctgatctgct ttcacaataa   5520
 ccgtatgggg ttttttctct ttcctttttt gtgagcggta tttaattcct ttgctctaat   5580
 atgtaatatt agaacatatt acaaagtagc aagaaaaata cgacattggt gtaaaaataa   5640
 tctacacctc atggaaagaa tgaagagcca gaaatagatt ctattctgta gaaaatctta   5700
 cacaataaag gacttcaaaa taagggtaag gaaggatgct ttaacaagcg gtgctgggat   5760
 aactggataa aaatttggga aaaaagtcat actatgtg                           5798



      <210> 1177
      <211> 5148
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(5148)
      <223> n = a,t,c or g


      <400> 1177
 ggcggtagtg cgtcggctgc tgcccgggtc tggcagaact cgggtttttt gggctgagac     60
 agtggcagct gcggccccga ccccaagtgc ggggacctcc ggcgaataaa ggtcggcctg    120
 cgggtaggcc ggtagggcct gcggtccggc ctgcgggaga actgggtcgt cagtcctccg    180
 agtggtgggg ctggggactt tgagggagtt ggctctaggg cacagtccct gcctggccag    240
 gtcggaggaa caagtgctgg gatctggcgt gtgtgctcca ggggctcttt ccgcggccct    300
 ttccacctct tttcactttg gggacggtag gcctttataa acggactaat gctgggtgat    360
 ttgttcctgt ggttgttgat gccgaggaaa gactctgggc cccaggactc acctaaactg    420
 gagttcgaat actgttcgct cgctgtgtga ccttggaaaa aaaaacaagc ttttctgaag    480
 tgagaagctg ttctcagcca cgagtcctgt gcaagatcac taatgattac ctggcatttc    540
 tgcgacacag gcaggtcctc agggtttgtg caagtttgca aacatgttca ccctgtctca    600
 gacctcgaga gcatggttca tcgaatagag cccgtcaggc acgaaaagaa aggcttgtgc    660
 agaaggaacg ggagcgggca gctgttgtga tccaggccca tgtccggaag ttttnctact    720
 gtcggagtcg actgcagaga gatatcagga gagagattga tgactttttt aaagcagatg    780
 accctgagtc cactaaaaga agtgcacttt gtattttcaa gattgccagg aaactgctgt    840
 tcctattcag aatcaaagag gataatgaga gatttgagaa gttgtgtcgc agcatcctga    900
 gcagcatgga tgctgagaat gagcctaagg tgtggtatgt gtccctggct tgttctaagg    960
 acctcaccct cctttggatt caacagatca agaacatttt gtggtactgc tgtgattttc   1020
 tcaagcagct caagcctgaa atcctgcagg actcccgact catcaccctg tacctcacga   1080
 tgcttgtcac cttcacagac acttcaacgt ggaaaattct tcggggaaaa ggtgaaagtc   1140
 ttcgaccagc gatgaaccac atttgtgcaa atataatggg acatctcaac cagcatggat   1200
 tttattctgt gctgcagata ttgttaaccc gtggcctggc aagaccccgt ccttgtctat   1260
 ccaaaggcac tttaacagca gctttttctc tagcgttacg ccctgtgatt gctgcacagt   1320
 tctcagacaa tctgattcgg ccgttcctca tccacatcat gtgtgtgcct gctctggtga   1380
 ctcatctcag cacagtgacc cctgagcgcc tcactgtttt agaatcccat gacatgcttc   1440
 gtaaattcat catattttta agagaccaag atcgatgccg tgatgtatgt gaaagtttag   1500
 aaggatgcca tacgctttgt ctaatgggca acctcctaca cttgggctcc ctcagcccca   1560
 gagtgttaga ggaggagaca gatgggttcg tgagtttgct cacccagacg ctgtgctact   1620
 gtcggaagta tgtgtctcag aagaagtcca acctgaccca ctggcatcct gtccttggct   1680
 ggttctccca atctgtggat tatggcctta acgagtcaat gcacttgatc accaaacagc   1740
 tgcagttctt gtggggggtg cctctgatcc ggatcttctt ctgtgacatc ctgagcaaga   1800
 agctactgga gagccaggag ccagcccacg cacagccagc atcccctcag aatgtgctcc   1860
 cagtgaagag tctcctaaag cgtgcttttc aaaagtcggc atcagtccgg aatattctca   1920
 ggcctgtcgg gggtaaacgg gtcgactctg cagaagtcca gaaggtttgc aacatctgtg   1980
 tcctctacca gacctcgctg acaactctca cacagattcg gctgcagata ctcacaggtc   2040
 tcacttacct tgatgacctg cttcccaaac tgtgggcatt tatctgtgag ctcgggcccc   2100
 acggagggtt aaagctcttc ttggaatgcc tgaacaatga cactgaagag tccaagcaac   2160
 tcttggccat gctgatgctg ttctgtgact gttcgcggca cctcatcaca atccttgatg   2220
 acattgaagt ttatgaagaa cagatttcat tcaaactgga agagctggtc actatctcct   2280
 ctttcctgaa ttcttttgtg tttaagatga tctgggatgg aattgtagag aacgccaagg   2340
 gtgagacctt ggagctgttc cagtctgtcc acgggtggct tatggtgctg tacgagcggg   2400
 actgccggcg gcgcttcacc cccgaggacc actggctgcg aaaggatctc aaacctagcg   2460
 tgctcttcca agaactcgac agggacagaa aacgggcaca gttgatcctg cagtacatcc   2520
 cacatgtcat ccctcacaaa aacagagttc tactgtttcg aaccatggtt accaaggaga   2580
 aggagaaact ggggctggtg gaaaccagct ctgcctcccc gcatgtcact cacatcacca   2640
 tccgccggtc caggatgctg gagagcttgt ttgagtgccc ctggccactg gtgatcaatg   2700
 ccgagagctg ctaggaaggc agtgtgtgct gaacagtgga tgtttctgac attcttcaag   2760
 gacggctacg agcagcttag gcagctctcc cagcacgcca tgaagggggt catcccgtgt   2820
 gaagtttgtc aatgacctcg gggtggacga agcagggatt gatcaagacg gtgtttttaa   2880
 ggagttcttg ggaagagatc atcaagagag tttttgaccc agcacttcaa tctgttcaag   2940
 acaaccaagt ggggatgaga ggctgtaccc ctcacccaca tccatacatc catgagaatt   3000
 acctgcagct cttccgagtt tgtggggaag atgctgggga aggctgtgta tgagggaatt   3060
 gtggtggacg tgccatttgc atccttcttc ctgagccaac tgcttgggca ccaccacagc   3120
 gtcttctata gctcggtgga tgaactgcct tctctggact ccgagttcta taaaaacctc   3180
 acctccatca agcgctatga tggggacatc actgacctgg gcctgacgct gtcttacgac   3240
 gaggacgtca tgggtcagct tgtttgccat gaactgattc ctggagggaa gaccattcct   3300
 gttacaaatg aaaataaaat tagctacatc catctgatgg cacattttcg aatgcacact   3360
 caaataaaaa accaaacagc tgccctcatt agcggattcc gttccattat caaacccgag   3420
 tggatccgaa tgttctcaac tcctgaactg cagcgtctca tctctggcga caatgctgag   3480
 attgatctgg aagatttaaa gaagcacaca gtctactacg gtggtttcca tggaagtcac   3540
 agagtcatca tctggctctg ggatattctg gcctccgact tcacaccgga tgagagagct   3600
 atgtttctga agttcgtgac cagctgctcc agacccccgc tcctgggatt cgcctacctc   3660
 aagcctccat tctccatccg ctgcgtggag gtgtcggacg atcaggacac cggggacact   3720
 ctgggcagcg tcctccgggg cttcttcacc atccgcaagc gggagccagg cggccgcctg   3780
 cccacctcct ccacctgctt caacctgctc aagcttgccc aaactacagc aagaagagcg   3840
 tcctccgcga ggaagctgcg ctacagccat cagcactgaa cacgggcttt gaactctcct   3900
 agctcctgtc ccagccctgc ctccagggct cctgggctgc cagggacctt cagctcccag   3960
 aggcagtgtg gtcctgggaa tgtgaccaac atgccaggtg acattggccc ctagaccctc   4020
 tctatagcca tgagactcct tgtggcctca agaaatttag acgcccacga cagcactaca   4080
 cagcatctcc aggtgatgcc caaggcacag ggctgcagaa aataaacctc cagattccac   4140
 caacacgggt ccattcttcc tggtgatggc agaggggctt cttttagcta gtttgatctt   4200
 ttgggagtct gtcttttcct tagccgtctg agtgagctgt gtatgaacaa gtcccaggag   4260
 ttccaagagt ctagagtggt ttttgcagca tgggttgagt gtacaaagcc tactgtgcgt   4320
 gagatcctct ccttccgttt ctgaaatctc ttactcaggt aaggcctcgc caagcctcta   4380
 tgcaccccac aaagtttctg cctccatgcc gtccacagcg cctcttccca gacagccagg   4440
 cccatctgct gcccagggaa gcgcaggcgc ctgctaggga cgctatggac accgtgagtc   4500
 caaggcgctg ctcctgcctt gaagccacgc gctccacgcc gcggccctcc cattttctgc   4560
 gtcctcagcg ggctgagctg ccagagagcc ttcccggacc tattcccgtc ctatgcattc   4620
 acattggcat cctggtttgg gggaagaaaa acaacggccc ttagcagcag ccccgtttcc   4680
 agaatgtgct gcctgttccc caaagcctgc ttgtcccgcg gaggacggct gcctttgacc   4740
 ctgcttattt gtctcactgg ttatctaatg aggaacaaac actaacctaa ggtacacatc   4800
 ccatctgggc ggtggcttca ctcctgagtc tgcaaaatcc caggaaactt gggtcttgct   4860
 gcccatcctt cctcagcaca gggaacccgg aagcccgttg cactgacaga ggctcacacc   4920
 ctctgggttt tttgtttttt ttttaaactt catttctctt ccaacccatt gggttcctct   4980
 gccctcattc tttacctttg ttgtaagaac tttagctcca gggaactgag gcaaaggccc   5040
 tgtttgtggt ctgtgttgac agccacccac cctctcccac ctcatgctcc tgcacctgca   5100
 ccaccaaggt tgatgccgga ttcgaagcca ggaaggccca gtccctcg                5148



      <210> 1178
      <211> 1175
      <212> DNA
      <213> Homo sapiens


      <400> 1178
 attgaatgtc actactccag tgcggtggaa ttcggtgttt taagatgcct gagccagcca     60
 agtctgctcc cgccccgaag aagggctcca agaaggcagt gaccaaagcg cagaagaaag    120
 atggcaagaa gcgcaagcgc agccgcaagg agagttactc tgtgtacgtg tacaaggtgc    180
 tgaaacaggt ccatcccgac actggcatct cttccaaggc catgggcatc atgaattctt    240
 tcgttaacga catatttgag cgcatcgcgg gcgaggcttc ccgcctggcg cattacaaca    300
 agcgctcgac catcacctcc agggagatcc agacggccgt gcgcctgctg cttcccggag    360
 agctggccaa gcacgccgtg tcggagggca ccaaggccgt caccaagtac accagctcca    420
 agtaaacatt ccaaggggag acaacagctt ttagacatat cttttccaac agtcgtcact    480
 gctggacact gtttcatctt gcaaataaac caatgaaaat gagtgatcct agaagaagat    540
 aaatggaggt attttgaaca atcaaagaag gacaaatgaa cacctggctg agaaaaatta    600
 gctctttttt ctatgcataa aactattaaa atattcttca tagaaattta tgacacagga    660
 aacataaaga caaaattaaa ataactccta gtatctccta ttctttttat atgtatatta    720
 tatatactca tattcatata tacatatatc tcacatcatg tatcatatat aaaataaatt    780
 taggtgtcat gatatatatt tagataaata tacttagaaa cttttttatg gatgtataat    840
 ttatggatat attgataatt atgtatttgt tattgactac ttcaattgat tcccattttt    900
 atgcattata ttatagatta tatagctcac acatctttgt acataaatct ttgttcaaat    960
 attatttcct aaggatagac ttcatgaagt ggaaatacta aatcaaaagt gaaaaacatt   1020
 ttctaaggtt cttaacatat acattgccaa attgctattc aggatcatac caatttataa   1080
 tcccaaaata atatggaaat tcctgtttta tagcactcat atttacaata aattttaaaa   1140
 atcattgtta acctaatagt ccttcaaaaa aaaaa                              1175



      <210> 1179
      <211> 2513
      <212> DNA
      <213> Homo sapiens


      <400> 1179
 tttttttttt ttaaatttaa aaagatgtcc tcactgcaca agtgatctac gggctacagg     60
 caaggatggg agacggaggc ttcaacacaa ctcattgcac ttagaaccgt tactaaccga    120
 aacaccattt gcttgtcaac aatgtaccct tgacagcagg gagaaacttc tttatagtct    180
 ctgcttcaga caagatttac agctttctcc aaggccagag gccaattgtg accacaagtc    240
 ttgtttcttg tccaccagac ccaatcctct ggcaccttgt accccccgtt cctcagcaat    300
 atgctcggcc taggttccag aggcagctgg aaggaagcag ctatgggctc attcagttct    360
 gtttgcccaa atccagaagc cctaggaaag tcccgtctga gtcttgactc ctgacccttg    420
 cagtggctgg agtcggtact ggtgcacacc cccactccca cggtgtgggt agtgctgtga    480
 attggaaacc gcagataccc tggaggcctg gtagacagct gactgcccag cactgggcag    540
 actgatagtc cgtaagtctg atggcaatga cgacctagag ttctgaggaa aggaggtgga    600
 actcagagtt cctgtgctgg actgagaaac tgaatctgag gttggcgagt ctgagggtcc    660
 ctgcagggta gggctagcag cactagaagg gcagctcctc cttggaagat tgctgccagt    720
 gctgtttcca gaatgtggct ggctgctaaa ataccctggt gtccccgtaa atggggccaa    780
 cgagtctgtg gacacagggt gggcggggct ggaataggac gtggaagaga gggatgattc    840
 tgaagaaccg tgagaggggg ggtttccagg tctcagtgca gtagttcgat aactgtatcc    900
 tggagactgt gtaggatgtc ctctgaaggg ggaggaactc tgctgaagga ggctttgtga    960
 ttctgtccga ggactatcac actgcaggag ctggtagctg tatctggaag ggctgtaaac   1020
 tgttgctcct ttagagagtg ctgagcttaa tgtctctggg ccttctccat ctgcagggtc   1080
 tgagtctttc tctgtgatgt tactctccca tgtgggagag ggctctccct tttgggccac   1140
 cctcacgctg cttcggagga ccttggggat gctccctcct tctcggagtc gttctactga   1200
 tgtgggaacc atccacctac tgctgatatt ctcttgaggt ctgcagtgag atgaagaagt   1260
 gcctctggaa tctgatgggc ttaccgcctc caaatgggac atagaggaat gagatgggga   1320
 gaattttttg tgaggggaag atggagttcg ggctgaggat ccctgcacac catgggcacc   1380
 agtgtcggaa acggagttac tgctgccttg cccagctcct gcagacttgc ttttgctctg   1440
 tgcagagtca cctcccccac cagcagaatt ttccttagct tcttgtttcc gttttcggta   1500
 ctccagcagg gatacttttt tcctctgtgg tgggttctgg ggggcagatg ggactccttc   1560
 acaggccctt tcaccaccag gtgacaagga tccacgagag aggtctttca ttaagccatg   1620
 ttcatatctg ctggaaaatc cttctgcagg ggaacaatat cccccatcca aatgtaaagg   1680
 cttcctatcc cccactagag gagatcctcg atacagtcca tctgctcgag gcatagcatt   1740
 caaaggggag taggcataca tcaagttgaa ctctgtccga aatgcctggt ctgagtttct   1800
 cacgagggtc tgatgtccat ctccacttct gcttgggaaa ccagtctcag aagtgggtcc   1860
 gagggaggga tgaggagcca ggtcagaatg actgagttga gtagggaagg tctatcagca   1920
 cagctgttag tgttggagtc aaggtatcct acttttgcca aatccaggtc ttttcggtga   1980
 caaagctcaa actgtagagg agtgttgcag cgactagcag tagtaagaga tgttgactgg   2040
 tgaaaacatg aggctgtatc catttcgaca ctcctcttct cctgggtgag atgagccagg   2100
 tgtggccagc tggggactct ttgagcctga attgggaggg ggtggtgtga ctggagacag   2160
 aggccgaagt aacttggtga cattctgctc catcagatag cgagacttcc atttctttaa   2220
 tgggctcaac aagtctgcat tgtctttgca gatactagaa gagctactaa tctcattgct   2280
 ttggtatagg tgctgagttc tagtctcttg gggtacagat gatgtttgag tcatcccttc   2340
 ttctaaggct tgttttatcc agcgcttctt acaggagctg aatgtgccat caggcagaag   2400
 gggccttcga cgtctctcag ggataaaggg tgagccaaag cgaatggagg gttttggggt   2460
 gtgcaataac cgggaattgt tagactggta actgtttaag gcggtgcact caa          2513



      <210> 1180
      <211> 1164
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1164)
      <223> n = a,t,c or g


      <400> 1180
 agctcaagga tccttaatta atttaatccc cccccccccc ccccccgatt ccgggctcga     60
 aggctgtgcg gtctgccagg agctgcggcc ccgtccggcc cgggctggca tgggttggaa    120
 ttggagccta tcccccaacc cgaaggctaa cagcatcatg tggttactaa ctgttcctca    180
 ttcaccggtt gatgcctccc agaaaaaaac gccgccagcc ttcccagaaa gccccgctgc    240
 tgttccacca acaaccactg gagggcccca aacacagctg tgcatctaca cagcttccca    300
 tcactcacac tcgacaggtg cccagcaagc ccattgacca cagcaccatc acttcctggg    360
 tatcacctga ttttgataca gcagcaggaa gcttgttccc agcctaccag aaacaccaaa    420
 accgggcgag acactcaagt cgaaaaccta ccacctccaa gtttccacat ctaacttttg    480
 agagtccgca atcttccagt tcagagacat tggggatccc cttaatccga gagtgcccca    540
 gtgaatcaga aaaggatgtt tccagaagac ccttagttcc agtgctcagt ccccaaagct    600
 gtgggaacat gtcagtgcag gcacttcaga gcttacctta tgtgttcatt ccacctgata    660
 tccagacccc agagtcatcg tctgtgaagg aagaactcat tccccaagat cagaaggaaa    720
 acagccttct aagctgcact cttcacactg gcactcctaa tagcccagag cctggacctg    780
 ttctggttaa agacaccccc gaggacaagt atggaataaa ggtcacatgg aggagacgac    840
 agcacctgct tgcttacctc agggagagag ggaagctgag cagaagccaa ttccttgtga    900
 aaagctgact gccatcagta atctcaatag aaaagagata tgttttctgg agtcataaag    960
 gaattcaatt cctagggttt ttgnttttgg ttttgagatg taatattgct ctgttgccca   1020
 ggctggnagt gcagtggtat gatctcaccn tactgcaacc accacttcct ggggttcaaa   1080
 gcgattctcc tgcctcaagc ctccccaata agctgggatt nnaaggcacc agccaccatg   1140
 cctggctaaa ttttttgaaa tttt                                          1164



      <210> 1181
      <211> 2303
      <212> DNA
      <213> Homo sapiens


      <400> 1181
 tttttttttt ttcagtctgt catttttatt aagcctgcag agctgttttt tttttctaca     60
 cacgacaaat actttgatat aatctaggat aataaaatag ttgaacaact ttttaagatt    120
 tatatttgta tagaaacaat ctgtggaact cctcccctca aaatgaaggt gtctaaaaac    180
 agtgattcat cagcattgct ttaaataatt gtttggttaa aagttgtggt ttccattctc    240
 aaccgaaatg cgtctccatg cagttttcct tgggtccaaa gcttaaggcc ttgggaaggg    300
 ggccaagaaa aaaagaatgg ccactctcct ttctgtcctt cccttgtgtg gaggacagtg    360
 attgaaacag gggagttaaa aagccaggaa gaaaagaaat caattgcaca tctctagttc    420
 gcaagcgtca aagtcacaac aagtctgtac acaacaactc tctatctgta gatatgaaat    480
 tccatcatga tagcacagcg cctgcttgcc cctaaatgtt cctttcttct gctaatcatg    540
 tcagttacta tggatgggct gtggccataa gttctccctc aagggctggt ccttctgtca    600
 ccttgaagtg tcagcccctg aattatgcca cttggatgct atgtcttgat acccaataaa    660
 ggtctaccat cccctaagaa atcccttacc ccaccctcaa acccccaaag tgcctaagag    720
 tgaagacgaa gatgccatgg agacggcgtc ttcagtgaac acctccccaa agatgcccgg    780
 ggactcgggc ctatatcatc ccattgatct tagtccactc gtagatgtcc tgttcgcaca    840
 ctatgtcaga gttgatgagg aggtatctgt cacctacaca gaaatgcttc tgacaggcgg    900
 cgcacttgaa acattccagg tgatacactt tgtctttcac ccgcattgtc atctcatagg    960
 cacgaatccg cttgtcacag gatgcgcaga gaccgtcttg cccaaaaagc ctgagatagt   1020
 ctctccggca gagcttccgg cccagtttgt agtagaggcg ccgccccacc tcacccagcc   1080
 ggcagccaca gaggtcgcag ctcaggcagt cctcgtgcca gtactggtcg atggccttca   1140
 ggaagtagcg gtccccgatg ttctgctggc agccgccgca tgtcagcagg gatgggggga   1200
 tctgcagcac ctcatccact ggttcctctg aagggtccag gctcttcctt tcgatggccg   1260
 aggacattgg ggagggaggc ggggtgccgg gcggcggggg cgctcccttt gtggcgcggg   1320
 gctggccggc tgccggggct cggaccccct cgggtgctcg ggcgccgccg ccgccgccgc   1380
 cgtcgccgcc gctcctgcct ccgcttgctc ggcctccgcc ggcgagctcg cccctccgcg   1440
 ctcaaggaca gtcaccgcgc tcccttccat cccggtcccg ccgccgccac cgcccggtcc   1500
 ctctcgcgcg ctgtcgccgg ctccgcgccg cccgcgggga tggtgtgcgc ccgcccggcc   1560
 gcccggagcc cctggcacct ttccggcccc gggtcgcggc gccctgctcg ccgccgaggg   1620
 cagagagggg gcggcggcct aggggcgggg aggggaccgt gcgtctctct ccgggcttcc   1680
 tcctctctcg ggaaggtcta ttttggctca ggcttccctc tgtctctgtt tcatttcctt   1740
 tttcctgcct ctccactagc tactgcaagt tcaggttgaa aaatatcttc ttttcagagc   1800
 agttgttaca gcagatgatg taatcctggt ggcttccccc atcagatcta ggctgcctgc   1860
 cccacggata ccttctgggc taattgcctg ctttgcacct gttccttctc gggaggccct   1920
 ggcaccctag cacctggtgc ctgtgccatc tcccctctct gccaggacac ccagaggccc   1980
 ttgtgaatag caaagcccac ttaacggctg agggcaggtg ggggtatttc cttctcaatt   2040
 ctgctcaagg cccgttgctg ttctttgagg atgttgcaaa tccagggttt ggagggctgg   2100
 gcctcttggt ggcctggttg tctatctgat agggcggagc cttcaccctt gcagcgagct   2160
 ctctcacacc agatgtgctc tgcgtggaat cctaggccat caggggattc cttagcaagc   2220
 cctgcaggac ccaaatccta actcagaccc tcatcctcct actcagaatg tggagacttg   2280
 tgatcctcag tttggacgaa ttc                                           2303



      <210> 1182
      <211> 1840
      <212> DNA
      <213> Homo sapiens


      <400> 1182
 gcggccgccg ccgccgctgc ggacgggttg ggggagtgag ttgggagttt agcgcagtcg     60
 ccggagtgcg aggacaacga ccatccggcc ctagcctggc cgtgcgggtg ccgggagctt    120
 ccctttctca gcgcggcgcg aaggtggctc gccgtcagcg cctgcttccc tcgacctcgt    180
 cctcctcccc gctccggagg agctgcgaga tgtggcgcct ctgactccac ttctccccgc    240
 ccctgtcacc gagaggggga accgagctct cgcccactcg ccggaggaga cggcccctgg    300
 actcccaacc ccgcgcggcg aaaccatgag ctccgtccag cagcagccgc cgccgccgcg    360
 taggatcacc aacgtggagt ctctgttgct caccccgcag gagaacgagt ccctcttcac    420
 tttcctcggc aagaaatgtg tgactatgtc ttcagcagtg ctgcagttat atgcagcaga    480
 tcggaactgt atgtggtcaa agaagtgcag tggtgttgct tgtcttgtta aggacaatcc    540
 acagagatct tattctttaa gaatatttga cattaaggat gggaaactat tgtgggaaca    600
 agagctatac aataactttg tatataatag tcctagagga tattttcata cctttgctgg    660
 agatacttgt caagttgctc ttaattttgc caatgaagaa gaagcaaaaa aatttcgaaa    720
 agcagttaca gaccttttgg gccgtcgaca aaggaaatct gagaaaagac gagatccccc    780
 aaatggtcct aatctaccca tggctacagt tgatataaaa aatccagaaa tcacaacaaa    840
 tagattttat ggtccacaag tcaacaacat ctcccatacc aaagaaaaga agaagggaaa    900
 agctaaaaag aagagattaa ccaagggaga tataggaaca ccaagcaatt tccagcacat    960
 tggacatgtt ggttgggatc caaatacagg ctctgatctg aataatttgg atccagaatt   1020
 gaagaatctt tttgatatgt gtggaatctt agaggcacaa cttaaagaaa gagaaacatt   1080
 aaaagttata tatgacttta ttgaaaaaac aggaggtgtt gaagctgtta aaaatgaact   1140
 gcggaggcaa gcaccaccac ctccaccacc atcaagggga gggccacctc ctcctcctcc   1200
 ccctccacat agctcgggtc ctcctcctcc tcctgctagg ggaagaggcg ctcctccccc   1260
 accaccttca agagctccca cagctgcacc tccaccaccg cctccttcca ggccaagtgt   1320
 agaagtccct ccaccaccgc caaataggat gtaccctcct ccacctccag cccttccctc   1380
 ctcagcacct tcagggcctc caccaccacc tccatctgtg ttgggggtag ggccagtggc   1440
 accaccccca ccgcctccac ctccacctcc tcctgggcca ccgcccccgc ctggcctgcc   1500
 ttctgatggg gaccatcagg ttccaactac tgcaggaaac aaagcagctc ttttagatca   1560
 aattagagag ggtgctcagc taaaaaaagt ggagcagaac agtcggccag tgtcctgctc   1620
 tggacgagat gcactgttag accagatacg acagggtatc caactaaaat ctgtggctga   1680
 tggccaagag tctacaccac caacacctgc acccacttca ggaattgtgg gtgcattaat   1740
 ggaagtgatg cagaaaagga gcaaagccat tcattcttca gatgaagatg aagatgaaga   1800
 tgatgaagaa gattttgagg atgatgatga gtgggaagac                         1840



      <210> 1183
      <211> 349
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(349)
      <223> n = a,t,c or g


      <400> 1183
 ggcacgagcg gcacgagtga agaagctttg tccaagttta cattgaaaaa ggtattgttg     60
 ttggtctgtt ttcttgatta tgctaaaatt tccagactca ttgatcatga tccttgtctc    120
 ttctgtaaag atgccgaatt caaggctagt aaagaaatcc ttttggcttt ttcacgagat    180
 ttcctaagtg gtgaaggtga cctttcccgt caccttggct tattgggatt acctgttaac    240
 catgttcaga caccatttga tgaatttgat tttgccgtta caaatcttgc cgtagacttg    300
 caatgtggag tgcgccttgt gcgaaccatg gaacttctca cacagaacn                349



      <210> 1184
      <211> 936
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(936)
      <223> n = a,t,c or g


      <400> 1184
 ctggcggccg ttgaaaaatg gcgactgtgg cagagttgaa ggctgtttta aaggacacct     60
 tggaaaacca gggggtatta gggcatttaa aagcaaggat ccgagctgaa gttttcaatg    120
 ccctagatga tgaccgtgaa ccccgaccat cattgtctca tgaaaacctt ctaattaatg    180
 aattaattcg agagtattta gaattcaaca agtataagta tacagcatct gtcctcatag    240
 cagaatctgg tcaacctgta gttccgttgg acagacagtt tctcatccat gaactaaatg    300
 catttgaaga atcaaaggat aatacaatac ctcttttata tgggatttta gcccatttct    360
 tgcgtggaac taaggatggc atccagaatg catttctgaa agggccttca cttcagcctt    420
 cagacccaag tcttggcaga caacctagta gaagaaagcc aatggatgat cacctaagaa    480
 agaaggagca gaaaagtact aacattgaag atcttcatgt ttctcaggca gtcaacagat    540
 aatgctttgt ttggggtatc ttttgtctta aaattgtatt attaattaaa taacttattt    600
 attgtcccaa tgttaccaaa atgcaccact aatgtttgta gaaattagag tttctacaaa    660
 acacccctca tgtttaacta catttgtgaa taaaagctaa ctcttgtcat ctagcttatt    720
 ggatttgact tgaaaaaaaa agtattgttt ttacaaagta ttttttgttt ttttgagatg    780
 gagtctcgct ctgtcaccca gactggagtg cagtggcacg attctcggct cactgcaatc    840
 tctgcctccc ggattcaagt gattctcctg cctcagcctc ccaagtagct gggaaaacag    900
 gcctgtgcca ccacaccgga gtagtttntg tattgt                              936



      <210> 1185
      <211> 996
      <212> DNA
      <213> Homo sapiens


      <400> 1185
 ctcgcggtca cctcttgtta ctgttttcat tttccctttc aatgaaatgg tgtgaagatg     60
 ggaggcacaa gagagggatc ctgttttttc tgcgggacac gtcttaatcc catcatgcgt    120
 gtttcttcag ctatgtattc taataatctg ctaaagtaga aagtaaaaga cctgctattt    180
 tatctcattg ggaccgtacg ttttagagat cgggaagtaa acagtccact aaccctgccg    240
 ataactatca tctggcccgg aggagaaccc tgcaggtggt tgtgagctcc ttgctgacag    300
 aggcagggtt tgagagtgcc gagaaagcat ccgtggaaac gctgacagag atgctgcaga    360
 gctacatttc agaaattggg agaagtgcca agtcttactg tgagcacaca gccaggaccc    420
 agcccacact gtccgatatc gtggtcacac ttgttgagat gggtttcaat gtggacactc    480
 tccctgctta tgcaaaacgg tctcagagga tggtcatcac tgctcctccg gtgaccaatc    540
 agccagtgac ccccaaggcc ctcactgcag ggcagaaccg accccacccg ccgcacatcc    600
 ccagccattt tcctgagttc cctgatcccc acacctacat caaaactccg acgtaccgtg    660
 agcccgtgtc agactaccag gtcctgcggg agaaggctgc atcccagagg cgcgatgtgg    720
 agcgggcact tacccgtttc atggccaaga caggcgagac tcagagtctt ttcaaagatg    780
 acgtcagcac atttccattg attgctgcca gacctttcac catcccctac ctgacagctc    840
 ttcttccgtc tgaactggag atgcaacaaa tggaagagac agattcctcg gagcaggatg    900
 aacagacaga cacagagaac cttgctcttc atatcagcat ggaggattct ggagccgaga    960
 aggagaacac ctctgtcctg cagcagaacc cctcct                              996



      <210> 1186
      <211> 1196
      <212> DNA
      <213> Homo sapiens


      <400> 1186
 ccggccggat tcctgggcga catttccgca ctgggcgcgc gagagctgct agggcggttt     60
 ctctgcctcg ggcctgttgg gcagggccgg ctaaggtgcg cgtgctcgct ggttctaacc    120
 cttctgttgg gcgtttctgc ggagaggcgg gaggcgctga gagtctgtgc ggaggtccat    180
 gcacagactg ctttgcctgt tgttgctctt cggaggcggc gatccccgaa ggcgagctga    240
 aatacggctg caggctacaa tttgcagccg acgattaagg aagacgacga gcgggagagg    300
 tggcccaccc tcatggagcg cttgtgctcg gatggcttcg catttcccca ttactacatt    360
 aaaccgtatc atctgaagag gatccacaga gctgtcttac gtggtaatct ggagaaactg    420
 aagtaccttc tgctcacgta ttatgacgcc aataagagag acaggaagga aaggactgcc    480
 ctacatttgg cctgtgccac tggccaaccg gaaatggtac atctcctggt gtccagaaga    540
 tgtgagctta acctctgcga ccgtgaagac aggacacctc tgatcaaggc tgtacaactg    600
 aggcaggagg cttgtgcaac tcttctgctg caaaatggcg cccgatccaa atattacgga    660
 tgtctttgga aggactgctc tgcactacgc tgtgtataat gaagatacat ccatgataga    720
 aaaacttctt tcacatggta caaatattga agaatgcagc aaggtatagg tcaaccaatg    780
 ttattttcaa actatctgaa atgcatttat tttaacattg acacatgtaa gggtcaattt    840
 ttcatatttg gaagctcaaa cattccttga atgaaaatat tttgaaatgc cttaactgtc    900
 taagatttta ctttaaatat tggaactttt aaagaagcat tatagggaac agcctttttt    960
 catgcactta tggtaaataa ctataaaaac aaatgaatta caataaattt ataattcatg   1020
 acaactgaat ttgggaaagg taatagttaa gtgtttttcc cctaaattac tttttttcta   1080
 atcagtgtga agtgacacag gaaagtaaaa ttgtccctta taaataggct ttattttaaa   1140
 tgtcaaagaa aattaaagaa tttcccaata aatgtacatg ttgttgctgt tgaaaa       1196



      <210> 1187
      <211> 607
      <212> DNA
      <213> Homo sapiens


      <400> 1187
 tcggggcagg aaatggagtt gggtgcccca ggtggggtgc tccaacgagc tctttctcat     60
 gggatccccc acagatccat acaaacaggc tgaccatcag ggctggtccc aggccaccag    120
 gctgggtgca atgcagaaat ggagatctgc cccggggaag gcagggtttc tgcccaaacg    180
 gagccacgtg aggacgtctt tggggatgtg tctccaagaa aagtgtgggc tgccttcctc    240
 accctggatg cctgtgggct gccttcctca ccctggatgc ctgtgggctg ccttcctcac    300
 cctggatgcc tgtgggcagc cttcctcacc ctggatgcct gtgggctgcc ttcctcaccc    360
 tggatgcctg tgggctgcct tcctcaccct ggatgcctgt gacttggttt ccatgggggc    420
 ttcctaagct cagggacccc aagcctccat caaatctaat gacccgccct gtctctgaac    480
 acacctgtgt tgtccccgag cccctcacca accccctctg caacccggcc cacgcatttc    540
 ccatccctga agggtccagc tcataggccg gcccatgtgt ttccctttaa cccctgcttt    600
 gtcccta                                                              607



      <210> 1188
      <211> 489
      <212> DNA
      <213> Homo sapiens


      <400> 1188
 ttgtcacctc attacgccaa gcttggggaa gggaactact tcagtttgat cacgggcagt     60
 caaatccaac ttactacatc aggctggcta atcgtgatct agttctgagg aagaagcccc    120
 cagggacact ccttccatct gcccatgcca tagagaggga gttcaggatt atgaaagccc    180
 ttgcaaatgc tggagtacct gtccctaacg ttcttgatct ctgtgaagat tcaagtgtca    240
 ttggcacccc cttctatgtg atggagtact gcccaggtct catctacaaa gacccttccc    300
 tgccaggctt ggagcccagc cacagacgag ccatatacac tgccatgaac acagtcctgt    360
 gcaaaattca cagtgtggat ctgcaggctg tgggacttga agactatggg aagcaaggct    420
 cgacaacctg ggtgtttcat ccagaagagc cagaggtgct ttgctgttcc ttgactggga    480
 actttctac                                                            489



      <210> 1189
      <211> 822
      <212> DNA
      <213> Homo sapiens


      <400> 1189
 tttttttagt taaacaatca ttttattgct tgagtacaca gacaaattta tgcgaccagg     60
 gcagaggctg tagatgattc atatttccaa ttgggaggga ggactcgctt ggtcttataa    120
 tatcgagcca aacggtgaat ccggctctct attagaatca gacggaattt agcatcctta    180
 tcctttctgt tcctctcaag atgctttcga acagcaactg ctttcttaat taaatggtag    240
 agatcttcag gaagatcagg agcaagtccc ttagacttaa gaattcttaa aattttgttg    300
 cctgatcgcc gccatcatgg gtcgcatgca tgctcccggg aagggcctgt cccagtcggc    360
 tttaccctat cgacgcagcg tccccacttg gttgaagttg acatctgacg acgtgaagga    420
 gcagatttac aaactggcca agaagggcct tactccttca cagatcggtg taatcctgag    480
 agattcacat ggtgttgcac aagtacgttt tgtgacaggc aataaaattt taagaattct    540
 taagtctaag ggacttgctc ctgatcttcc tgaagatctc taccatttaa ttaagaaagc    600
 agttgctgtt cgaaagcatc ttgagaggaa cagaaaggat aaggatgcta aattccgtct    660
 gattctaata gagagccgga ttcaccgttt ggctcgatat tataagacca agcgagtcct    720
 ccctcccaat tggaaatatg aatcatctac agcctctgcc ctggtcgcat aaatttgtct    780
 gtgtactcaa gcaataaaat gattgtttaa ctaaaaaaaa aa                       822



      <210> 1190
      <211> 1973
      <212> DNA
      <213> Homo sapiens


      <400> 1190
 tttttttttt ttctctccaa gtccttcctt taatgtcagg tagtgcttca acccaaacac     60
 aagcagtata cataccatag agaaagggac ctgagggcat ctgagtcatg catggtgtgg    120
 tacatacaaa ccttggccca gcccaaagga gcagtcaagg gcctggaaga aagatggttt    180
 gctctttccc cctcctcctc tctctttcct accgggctta aagtccgtgg aagagaaagt    240
 ttttaatcag tggaactgat aaggcctcag ggccgtggag ggtagatttg gttgttcagt    300
 aatataaaat gtgtttaaga aaaaaaacag cccaggcttc ccagcagtag cccatgtgtt    360
 ggctggttca gcagcctgac ctctacatct agacaaggaa gtgaggaggg tgattgctgg    420
 gcattggtgt aggtttatga cggagcagca taagattttc cgtgccctgt gaacacgtat    480
 acaaacattc atagcccctt cccctcagcc ctgctctgct gcaaggaagc tgctgagagt    540
 gagtgaacag ctggggccac aaagtgtctt gtgagaccag ctatagggtc taatgcagtg    600
 aagtcagtca tttaggacct attttcacac aggggcaagg aaaaaccaga aacaacttct    660
 ctcttaccct ttaaactaag atacttcatt ctacacgatt acctgaaaca aatgtctcag    720
 gtcaaatcac aagccttagc ttctgctagg gtttgaagtc tgggaaatat ataatccagc    780
 tcttctcttt cagtccaagc tctagcttgt cagcaagact gttgcagaag atctatcctt    840
 aagaggcaga aacatctgcg gtgaggaagg cagctattga aggtattcca ggagcatgag    900
 actgagtttg cagagctgag ggttgtcaat ttccttttct actgatatct tcttccttta    960
 gagcaaactt cctccttagg acctcagaga taagcacagc agggtcttcc tccttcaata   1020
 aactccggtt cagatcttga ctctgtttca ttcggtgaaa gtccttcagg atacccatca   1080
 tgtctgcaaa gctgctggcc ttggacaaag agacgcagtc atcctcttca gacgaactgc   1140
 aggcagcttt gtgttctggt ttgcaacatt cagggctggc agaacaaagc agggggactg   1200
 atggaagctc agggacctcc acctctgtct cctcggtgat gtcactaatg acaaaggaag   1260
 ttgtagagtg gaatgaggat ccaaaacaag gtaagggaga agagacattt gaacttcctg   1320
 gagataagaa atctggcgtt aatgaagccg aagctgcatc agctgccact atctttgcaa   1380
 tctggctgcg caagtggctc agctcgtcct gcagctcagt agtgcggctt agggctggca   1440
 gagctggctt cttcagggcc agaagcctct cctcggaccc acgcaggttg ggaacagagg   1500
 cattgcgctg catgacaatc agagggctgg gtttccaggt gtgcctcagg gggcgcgtat   1560
 cactcctgac ccgggcatat gtctcctctt catccgcagc aatccaggcg atgtcagcca   1620
 gggtagggac tgggggcaca tctctcaaac acaggtcaga gatgttgggc agggtctcaa   1680
 aggacgcccg ggcacacggc ttcaagggta ggttggtccc aattcttctt actacacttc   1740
 gagcagcccc atgtggcttg ttttgccaga ttgggatggt cacagtggct tccattcctg   1800
 acatttgaac cagctcctgc acttgaagga caaggcagcc actgggcagc tccgggaggc   1860
 gggaggcgtg actccttcat atcaggccat ctcaagctcg ggctcccgga ctctctcacc   1920
 tcacggcccc tccttccacc ttgggccgcc cagcctcgtg ccaagcttgg cgt          1973



      <210> 1191
      <211> 4227
      <212> DNA
      <213> Homo sapiens


      <400> 1191
 atggacccag tccttatgga tcatagtcca ggaaagagga aacaccggat aggagagctc     60
 aaggttacca ctgactattt cctaacagta cacatgggct ccaaaaatca tgttttcacc    120
 caaaccagct cttccctgga aaaactatct ttctcaccaa ctgagctgaa ggggatggga    180
 gtagccccag acaaaaaggt ggcaaactca cactgttctt ccccaaattc cagtgctgct    240
 gataagtctg atgacattct ggttgccatt ttttctgtga acaaaagtgc ctgcctgcca    300
 gctctggaga gagcagcaga tctcccagca cagaggactg gtcaaagaac taccgaagaa    360
 aacattcctt tggggccacc agtgaatgaa aatgtgagtc tagctatctc aggcagatac    420
 ctctcagcag gggttgacag acacctcata caggagatct ctggctggca tttgctgggt    480
 gcccctctgg gacgaagctt ccagaggaag gaaaaggaag caatctttgc tgttctgcag    540
 cctccgctgg tgatacccag gcaaacaggg tctggagtgg accaccagca aactccagca    600
 gacctgcagc agagaggcct tactgttaga aggaaaacta accaacagaa aggaatagca    660
 tcaacatcaa caaaaaggat gtccacacaa aaaccccatc tgaaggtcac caacatcaaa    720
 gcacgggaac aaaactggac agagaatgag tttgacaaat tgacagaagc aggcttcaga    780
 aggtgggtaa taacaaactc ctctaagcta aagcagcttg ttctaaccca atacaaggaa    840
 gctaagaacc ttgaaaaaag gttagacgaa ttgctaacta gaataaccag tttggagaag    900
 gacataaatg acctgatgga gctgaaaaac acagcacgag aacgttgtga agcatacaca    960
 agtatcgata gccgaatcaa tcaagcaaaa gaaaggacat cagacactgc agatcaactt   1020
 aatgaaataa agtgtgaagg caaggttaga gaaaaaagaa tgaaaaggaa cgaacaaagc   1080
 ctccaagaaa tacgcgaata tgtgaaaaga ccaaacctac atttgattgg tgtatgtgaa   1140
 agtgacgggg acaatggaac caagttggaa aacactcttc gggatattat ccaggagaat   1200
 gtccccaaca aaatcagcag ggaggtgaag cttatagagc tgtaaaatgg actgaagcaa   1260
 actggacacc tgactagaga ccaggacatc ctggcctagt ttcaggttgt gcggcacttt   1320
 cctctgactt gtagctacct gcacactcca tttattcgtg tctgcgataa tacagacagc   1380
 ttcagctatt ggctcatcca ggactggatg ctggtcaaca gtgctgaggt taagaaatcc   1440
 tgctctaggg tgaacagcca ctgtggaatg ggagaacaca gttggcttat actgctttaa   1500
 gagtgtagca caaagccagg gccttaagtc agcaggtgat gaatcctgcc agtactgggt   1560
 ccttcccttc aaggcagcgg gttcctttgt gcccaggctg tgtctttttt caaggttctt   1620
 agcttccttg cattgggtta gaacatgctt ctttagctca gaggagtttg ttattaccca   1680
 ccttctgaag cctacttctg tcaattcatc aaactcaatt ctccatccag ttttgttccc   1740
 ttgctggtga ggagctgtga tcgttggtga ccttcggatg gggtctctga gtggacgtcc   1800
 tttttgttga tgttgatgtg gctgttttct gcttgttaat tttccttcta acaggcctgt   1860
 ctgctgcagg tctgctgtgg tttgttggag gtccactaca gaccctgttt gcctgggtat   1920
 caccagcgga ggctgtagaa cagcaaagat tgctgcctgt tccttcctct ggaagcttcg   1980
 tcccagaggg gcacccacca gattccagcc agagctctcc tgtatgaggt tctgtcggcc   2040
 cctactggga ggtgtctccc agtcaggata cacaggggtc agggatccac ttgaggaggc   2100
 agtctgaccc ttagcagagc tcaaacgtgc ccgctttcca gtcgggaaac ctgtcgtgcc   2160
 agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgccagg   2220
 gtggtttttc ttttcaccag tgagacgggc aacagctgat tgcccttcac cgcctggccc   2280
 tgagagagtt gcagcaagcg gtccacgctg gtattgcccc agcaggcgaa aatcctgttt   2340
 gatggtggtt ccgaaatcgg caaaatccat taattgcgtt gcgctcactg cccgctttcc   2400
 agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg   2460
 gtttgcgtat tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga   2520
 ttgcccttca ccgcctggcc ctgagagagt tgcagcaagc ggtacacgct ggtttgcccc   2580
 agcaggcgaa aatgctgttt gatggtggtt gcgaaatcgg caaaatctag acactaaatc   2640
 tgctggtgcc ttgatcctga acttcccatc ctccaaattt ctgttactta taagccactc   2700
 agtgtatggt attttgttac tgcagtccag atgaactaag acaggtgtcc ccatcccctg   2760
 ggctgtagac gtgtaacccg ttaggaactg agctccctcc cggacgggtc ggctggcggt   2820
 acgggggctg cccctcacct ctctcccaga tggggcagct gccgggcgga gacgctcctc   2880
 acttcccata cggggtggaa aatcagcagg gaggtgaagc ttatagagct gtaaaatgga   2940
 ctggagcaaa ctggacacct gactagagac caggacatcc tggcctagtt tcatgttgtc   3000
 cgtcactttc ctctgacttg tagctacctg cacactccat ttatccgtgt ctgcgataat   3060
 acagacagct tcagctattg gctcatccag gactggatgc ttgggatttg cagcctcttg   3120
 accccgaacc ccatctacca acaatgacag tccacaggaa cttgcagtgt tccgtaagtg   3180
 ttccttaaga caaatgctgc tctgatcggc aggagagagg ccacacggcg tgtcaatgtc   3240
 aaaattatat ttatgtagca tctgctgcca gccacggacc ttctcttggc agaggcagct   3300
 tctcttccta ggaacctcag gtgatttacc accgtgaccc agatctagca tggctgaagc   3360
 gcaggcttcg tcgtcactgt ctcccagggc gctatctgag ctttcatttc ggggaatgtc   3420
 tccttcagtc ctgaagttgg ccctcttgtt gtcatcccca caagggatat tcgtaaaaag   3480
 cacgaggcca ggggcccgct ggacacacct gtgggctggg ccccagtaaa gctgaacctg   3540
 ggttgccatt cttgaggacc agggcttaaa ttccccaaaa cccaaatcct catttctcag   3600
 tggccgttga acaaggtaat ttttaccgag gattttggac aggaagttag aagaagggct   3660
 ttttcccagc tgtgcccaaa gaggattata cggatgtgtt ttggccagca tgttcactga   3720
 ctgggaggta cgtttctctg agaaggcttt gatgggaggg tgatccacag gcatgacagt   3780
 tgggacccag gccaggtggt aggttaacac cgcagtcagt aaggcagcaa aaaactggtt   3840
 tttatttatc tgttctatca gaagtgtaaa ctccttgaga aagcgctggc agagctggtt   3900
 tttttccaaa gtgccggaca tcatagtaag ccatacaggt tcagctatcc ttggaacaga   3960
 atataagttc cagatagttc ctcttgggat ttgcaggctc ttgaccccga acccatctac   4020
 caacaatgac agtccacagg aacttgcagt ggttccgtag tgttccctga ggtgggagga   4080
 tcccttctgt tttggagatc ggagctgccc tgagtccaac atccaactgg ccttccgcct   4140
 ggggtggcag agccagactc tgcttgcaga tttgccaaca agcactgtgg tggaattcca   4200
 atgtggtgga attcgccact ggaccat                                       4227




      <210> 1192
      <211> 940
      <212> DNA
      <213> Homo sapiens


      <400> 1192
 tgattacgga agaaccagga gtttggcgtg accatgggga agcaaaagaa aacaaggaag     60
 tatgcgacca tgaagcgaat gcttagtctc agagatcaga ggcttaaaga aaaggataga    120
 ttaaaaccta aaaagaaaga aaagaaggat cccagcgcat taaaggaaag agaagttccc    180
 caacaccctt cctgcttatt tttccaatat aatacacagc tgggcccacc ttaccacatc    240
 ctcgttgata ccaactttat caacttttcc ataaaagcca aactggactt agtgcagtca    300
 atgatggact gtctgtatgc caagtgtatc ccatgtataa ccgattgtgt aatggctgaa    360
 attgagaaat tggggcagaa gtatcgagtg gctctaagga ttgccaagga tccaagattt    420
 gaacgattac catgtacaca caaagggaac ctatgcagat gactgcttag tacagagagt    480
 aactcgccat aagtgttaca ttgtggccac agttgaccgg gacctgaaaa gaagaatccg    540
 taagattcct ggagttccta tcatgtacat ttctaaccat aggtgagaaa tttcccttgg    600
 agaagggaat agaaatatat aattgatatc aattgaaaat gaggataagt gataaggtta    660
 taaaggattt gaaagaaatt attgtatcaa atgtttacat agttatattt gaagaaatga    720
 gacaaagcaa gagcaagagc aaaagagaga gataggattt aaggaatgag gcaaacattt    780
 aaattgttag agtaagatta ctggaagaaa tagacgtatt gttttaaata aaagcagtaa    840
 tttaaatcaa gctaatcttt ttggccagaa atacctgttt tgaaagattt ttttttatta    900
 acacttcatc tgagaaatgg aaagcttatt taaaaaaaaa                          940



      <210> 1193
      <211> 396
      <212> DNA
      <213> Homo sapiens


      <400> 1193
 cggacgcgtg ggctgtaccc ggcgttcgcc cagcctggcc aggagtgcta cctgcagaag     60
 gagcctctgc tcttcagctg cgccggctcc aacaccaagt accgccggct ctgcccctgc    120
 cgcgacttcc gcaagggcca ggtggccttg tgccagggct gtctgtgaat ccgcctctgc    180
 caccctgcct ggcacccacg ctggctctct cctgccgcgg gagaaagcac cagcaggttc    240
 tgagccctgg ctgcttgtcc tcctcgcaac ccccccaggc cggagcttcc ttccttagcc    300
 gggaagctgg cagaggagag ccgtgcccgg gaataggagg aggcagcatg ccgagcccct    360
 gggacctccc aggcaggctc cggttctctc ctgggg                              396



      <210> 1194
      <211> 469
      <212> DNA
      <213> Homo sapiens


      <400> 1194
 tttcgtggac tccccgcgct tcagggcgac cattgacgag gtggagacgg acgtggtgga     60
 gattgaggcc aaactggaca agctggtgaa gctgtgcagt ggcatggtgg aagccggtaa    120
 ggcctacgtc agcaccagca ggcttttcgt gagcggcgtc cgcgacctgt cccagcagtg    180
 ccagggcgac accgtcatct cggaatgtct gcagaggttc gctgacagcc tacaggaggt    240
 ggtgaactac cacatgatcc tgtttgacca ggcccagagg tccgtgcggc agcagctcca    300
 gagctttgtc aaagagtgag tggcccccag ggctggggga agaacactga ggccacgctc    360
 cctcccttgg aggggaaggg ggtctggggc agagcagaag caccttgtgc ccaggcctcc    420
 aagctgtgca gcggctccac aaggcaaaaa gctcagaagc agacagccg                469



      <210> 1195
      <211> 382
      <212> DNA
      <213> Homo sapiens


      <400> 1195
 gaggacgacg aggaggagac caccgcgtcc acgctgcggg gcaagcgcca ggccgccgcc     60
 cgtctcggcg cagtccgcct tcagctacat cccgccgcgg cgcctggacc ccacagagca    120
 cagctactac taccgcccgg cgcgggaaca ggagaggccg gctggagtgc tgacgtcttc    180
 tgtctatggg aagcgcatca atcagcccat tgagccccta aaccgggact ttggccgtgc    240
 caaccatgtg caggctgact tctacaggaa gaacgacatc cccagcctca aggaacccgg    300
 ctttgggcac attgctccat cctgaagcat acccgtggcc cacagggcat gtccgatacc    360
 ctgtggcctg gcaagtttgc ac                                             382



      <210> 1196
      <211> 1812
      <212> DNA
      <213> Homo sapiens


      <400> 1196
 ttttttttac taccattttt ttttaacact ggcatctgta ggtcactctc cagcagttag     60
 gcaccttaac tggagaccag aaaccttcca gagaacacag ggctgcatcc cgagcaaccc    120
 tctgaagaag ggaattaggc tttagatttt gatagcaatg ttccaggaat gaaatataga    180
 tgttagccca agacaccatg acaaaatagc ccagcctttt gagagtaatt tgggaaaaga    240
 agctgtcaga agtttctaac ttacaaactg gtttgaaatt tttgatgccc agacagcaag    300
 tataaatcat tttggaggct tacttttcat gatacaaaag caattctgtg tgattttttt    360
 ttttaagaag aaagaaaatg caagctagtt ttgagaaagg aaggccaaat tgggtcgggg    420
 gagggtggga gtgaggaagt taaaatcact atagggagaa aaaacttttt tcaagatttc    480
 caaagagatg aaattttctt aatcctttta agttttcata gtaaacagta tggcagattg    540
 ggttggttgt cctacctggt ctatttttaa aagtcacctt ttaaagtgac attattagat    600
 acacttaaat gtttccaagg cactctctgc attacccttg tttttctctt tggatactgt    660
 cctgggacta agtgtagatt tctgcttcaa gcacttctgg cattgtgtgt ttttgtatgc    720
 actccccttc atgccacttc agatgtttat ttggatgtgg ttggggacga gagcagacac    780
 caaggaaagg gagttggaga gaatgtaagt cctgacctga aggtcttttg tgatgcatgt    840
 ataggattgc cctgacacac accctccttt cttgggatta taccagccat cttcctgaga    900
 gttttggagc cctctaggat attttttcta gtaccccacc ccccacccct aaagaaagac    960
 cttaatatgt taaaacagca ttgcttggag aaggtgtcat tgaattccgg gacgagccgg   1020
 agcctttaaa tgggtgcttc caccactaca ggctcctgac acgagtaaca ggcactgttg   1080
 cttagaagaa cacacgaagt tgccgaacac agggtaaaat ttccaaggcg ctgatcgttg   1140
 ccctggccag ggcctgatga gagccagtca gtacattctt tttttcctac agttcttggg   1200
 tttcaaactt cagtttcagg gaatttcaag tcaacaacag gtagaatgaa taaacttggt   1260
 taccagccta ataatgtgaa ttgctacaga attattctta ttatgtaaga aaacaaaaac   1320
 tttatgcaga tactttagct ataaattgat gtaaaatact gattttttta aaggaaggag   1380
 agaacagtat cttgttcaat tattatgcaa tcaatcagta aatgttttta aaatgatact   1440
 acaggagaac acatcatgga ggacctggac acaaatgcag acaagcagct gagcttcgag   1500
 gagttcatca tgctgatggc gaggctaacc tgggcctccc acgagaagat gcacgagggt   1560
 gacgagggcc ctggccacca ccataagcca ggcctcgggg agggcacccc ctaagaccac   1620
 agtggccaag atcacagtgg ccacggccac ggccacagtc atggtggcca cggccacagc   1680
 cactaatcag gaggccaggc caccctgcct ctacccaacc agggccccgg ggcctgttat   1740
 gtcaaactgt cttggctgtg gggctagggg ctggggccaa ataaagtctc ttcctccaag   1800
 tcaaaaaaaa aa                                                       1812



      <210> 1197
      <211> 1812
      <212> DNA
      <213> Homo sapiens


      <400> 1197
 ttttttttac taccattttt ttttaacact ggcatctgta ggtcactctc cagcagttag     60
 gcaccttaac tggagaccag aaaccttcca gagaacacag ggctgcatcc cgagcaaccc    120
 tctgaagaag ggaattaggc tttagatttt gatagcaatg ttccaggaat gaaatataga    180
 tgttagccca agacaccatg acaaaatagc ccagcctttt gagagtaatt tgggaaaaga    240
 agctgtcaga agtttctaac ttacaaactg gtttgaaatt tttgatgccc agacagcaag    300
 tataaatcat tttggaggct tacttttcat gatacaaaag caattctgtg tgattttttt    360
 ttttaagaag aaagaaaatg caagctagtt ttgagaaagg aaggccaaat tgggtcgggg    420
 gagggtggga gtgaggaagt taaaatcact atagggagaa aaaacttttt tcaagatttc    480
 caaagagatg aaattttctt aatcctttta agttttcata gtaaacagta tggcagattg    540
 ggttggttgt cctacctggt ctatttttaa aagtcacctt ttaaagtgac attattagat    600
 acacttaaat gtttccaagg cactctctgc attacccttg tttttctctt tggatactgt    660
 cctgggacta agtgtagatt tctgcttcaa gcacttctgg cattgtgtgt ttttgtatgc    720
 actccccttc atgccacttc agatgtttat ttggatgtgg ttggggacga gagcagacac    780
 caaggaaagg gagttggaga gaatgtaagt cctgacctga aggtcttttg tgatgcatgt    840
 ataggattgc cctgacacac accctccttt cttgggatta taccagccat cttcctgaga    900
 gttttggagc cctctaggat attttttcta gtaccccacc ccccacccct aaagaaagac    960
 cttaatatgt taaaacagca ttgcttggag aaggtgtcat tgaattccgg gacgagccgg   1020
 agcctttaaa tgggtgcttc caccactaca ggctcctgac acgagtaaca ggcactgttg   1080
 cttagaagaa cacacgaagt tgccgaacac agggtaaaat ttccaaggcg ctgatcgttg   1140
 ccctggccag ggcctgatga gagccagtca gtacattctt tttttcctac agttcttggg   1200
 tttcaaactt cagtttcagg gaatttcaag tcaacaacag gtagaatgaa taaacttggt   1260
 taccagccta ataatgtgaa ttgctacaga attattctta ttatgtaaga aaacaaaaac   1320
 tttatgcaga tactttagct ataaattgat gtaaaatact gattttttta aaggaaggag   1380
 agaacagtat cttgttcaat tattatgcaa tcaatcagta aatgttttta aaatgatact   1440
 acaggagaac acatcatgga ggacctggac acaaatgcag acaagcagct gagcttcgag   1500
 gagttcatca tgctgatggc gaggctaacc tgggcctccc acgagaagat gcacgagggt   1560
 gacgagggcc ctggccacca ccataagcca ggcctcgggg agggcacccc ctaagaccac   1620
 agtggccaag atcacagtgg ccacggccac ggccacagtc atggtggcca cggccacagc   1680
 cactaatcag gaggccaggc caccctgcct ctacccaacc agggccccgg ggcctgttat   1740
 gtcaaactgt cttggctgtg gggctagggg ctggggccaa ataaagtctc ttcctccaag   1800
 tcaaaaaaaa aa                                                       1812



      <210> 1198
      <211> 1812
      <212> DNA
      <213> Homo sapiens


      <400> 1198
 ttttttttac taccattttt ttttaacact ggcatctgta ggtcactctc cagcagttag     60
 gcaccttaac tggagaccag aaaccttcca gagaacacag ggctgcatcc cgagcaaccc    120
 tctgaagaag ggaattaggc tttagatttt gatagcaatg ttccaggaat gaaatataga    180
 tgttagccca agacaccatg acaaaatagc ccagcctttt gagagtaatt tgggaaaaga    240
 agctgtcaga agtttctaac ttacaaactg gtttgaaatt tttgatgccc agacagcaag    300
 tataaatcat tttggaggct tacttttcat gatacaaaag caattctgtg tgattttttt    360
 ttttaagaag aaagaaaatg caagctagtt ttgagaaagg aaggccaaat tgggtcgggg    420
 gagggtggga gtgaggaagt taaaatcact atagggagaa aaaacttttt tcaagatttc    480
 caaagagatg aaattttctt aatcctttta agttttcata gtaaacagta tggcagattg    540
 ggttggttgt cctacctggt ctatttttaa aagtcacctt ttaaagtgac attattagat    600
 acacttaaat gtttccaagg cactctctgc attacccttg tttttctctt tggatactgt    660
 cctgggacta agtgtagatt tctgcttcaa gcacttctgg cattgtgtgt ttttgtatgc    720
 actccccttc atgccacttc agatgtttat ttggatgtgg ttggggacga gagcagacac    780
 caaggaaagg gagttggaga gaatgtaagt cctgacctga aggtcttttg tgatgcatgt    840
 ataggattgc cctgacacac accctccttt cttgggatta taccagccat cttcctgaga    900
 gttttggagc cctctaggat attttttcta gtaccccacc ccccacccct aaagaaagac    960
 cttaatatgt taaaacagca ttgcttggag aaggtgtcat tgaattccgg gacgagccgg   1020
 agcctttaaa tgggtgcttc caccactaca ggctcctgac acgagtaaca ggcactgttg   1080
 cttagaagaa cacacgaagt tgccgaacac agggtaaaat ttccaaggcg ctgatcgttg   1140
 ccctggccag ggcctgatga gagccagtca gtacattctt tttttcctac agttcttggg   1200
 tttcaaactt cagtttcagg gaatttcaag tcaacaacag gtagaatgaa taaacttggt   1260
 taccagccta ataatgtgaa ttgctacaga attattctta ttatgtaaga aaacaaaaac   1320
 tttatgcaga tactttagct ataaattgat gtaaaatact gattttttta aaggaaggag   1380
 agaacagtat cttgttcaat tattatgcaa tcaatcagta aatgttttta aaatgatact   1440
 acaggagaac acatcatgga ggacctggac acaaatgcag acaagcagct gagcttcgag   1500
 gagttcatca tgctgatggc gaggctaacc tgggcctccc acgagaagat gcacgagggt   1560
 gacgagggcc ctggccacca ccataagcca ggcctcgggg agggcacccc ctaagaccac   1620
 agtggccaag atcacagtgg ccacggccac ggccacagtc atggtggcca cggccacagc   1680
 cactaatcag gaggccaggc caccctgcct ctacccaacc agggccccgg ggcctgttat   1740
 gtcaaactgt cttggctgtg gggctagggg ctggggccaa ataaagtctc ttcctccaag   1800
 tcaaaaaaaa aa                                                       1812



      <210> 1199
      <211> 994
      <212> DNA
      <213> Homo sapiens


      <400> 1199
 cgtacctaca aggcacggtt gaacacattc aagggtgtaa gcgccccagg gtggtgtccc     60
 attccttggg tccagtgtaa aagcgcgccc aaaggcatga ggctgtcttc cctccatcct    120
 tggaggcggc cacaagtgct gctgtccgca gccatgtcct ggactcggca cttatcagca    180
 cttttgagct gtcttctggg gtcctggtaa aaaggattgc tttgcctgcc tgattcaaga    240
 caagggaccc ccttcccaac agcacctccg ccccttgccg tgcaacccag tggtctccag    300
 tcaccccacc acatcgtccc ctctgtaacc tgacggtctc cagttccccc accaccttcc    360
 cccagaacct gttggtctcc agtccccacc ccatcaccac caactcccat ctccccactt    420
 ggaacccagc agtctcgtat ctccatcagt gaggacagtg tgagaaatgg tgtctggctc    480
 aggcacttgg cagcagcttg aggggtcctc agatgtctcc tgcccagcaa ggatctgact    540
 aaagcagtcg tgggtgtggg aggggcctgc aggcatgcct ggggttgggg gcagctggcc    600
 ctgggcaccc tggtgcaggt ccagtctgcc ctctggatgg cccctcctct tccccagatt    660
 actactttgt aaccagggag gtgatgcagc gtgacatagc agccggcgac ttcatcgagc    720
 atgccgagtt ctcggggaac ctgtatggca cgagcaaagt ggcggtgcag gccgtgcagg    780
 ccatgaaccg catctgtgtg ctggacgtgg acctgcaggg tgtgcggaac atcaaggcca    840
 ccgatctgcg gcccatctac atctctgtgc agccgccttc actgcacgtg ctggagcagc    900
 ggctgcggca gcgcaacact gaaaccgagg agagcctgat gaaacggctg gctgctgcac    960
 aggccgacat ggagagcagc aaggagcctc gaaa                                994



      <210> 1200
      <211> 654
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(654)
      <223> n = a,t,c or g


      <400> 1200
 cacagactca gagagaaccc accatggtgc tgtctcctgc cgacaagacc aacgtcaagg     60
 ccgcctgggg taaggtcggc gcgcacgctg gcgagtatgg tgcggaggcc ctggagagga    120
 tgttcctgtc cttccccacc accaagacct acttcccgca cttcgacctg agccacggct    180
 ctgcccaggt taagggccac ggcaagaagg tggccgacgc gctgaccaac gccgtggcgc    240
 acgtggacga catgcccaac gcgctgtccg ccctgagcga cctgcacgcg cacaagcttc    300
 gggtggaccc ggtcaacttc aagctcctaa gccactgcct gctggtgacc ctggccgccc    360
 acctccccgc cgagttcacc cctgcggtgc acgcctccct ggacaagttc ctggcttctg    420
 tgagcaccgt gctgacctcc aaataccgtt aagctggagc ctcggtggcc atgcttcttg    480
 ccccttgggc ctccccccag cccctcctcc ccttcctgca cccgtacccn cgtggtcttt    540
 gaataaagtc tgagtgggcg gcnnnnnnnn nnnnnnnnnn nnnntnnnnn nnnnnnnnnn    600
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ngggnnnnnn nnnnnngccg cgcg          654



      <210> 1201
      <211> 423
      <212> DNA
      <213> Homo sapiens


      <400> 1201
 gtgaactcca agactgtttt gatgttcatg atgcatcttg ggaagagcag atattctggg     60
 gatggcataa tgatgtccac atatttgaca caaagacaca gacttggttt caaccagaaa    120
 ttaaaggtgg agttccacca cagccacgag ccgcgcatac gtgtgcagtt cttggaaata    180
 agggttatat ctttggcgga cgtgttctgc aaactaggat gaatgatttg cactatctaa    240
 acctagacac ctggacttgg tctggaagga ttactattaa tggagaaagc ccaaaacatc    300
 ggtcatggca tactttaaca cctatagctg atgataaact tttcctatgt ggtggactaa    360
 atgcatataa tatgccatta agtgatggtt ggattcataa tgtcacaaca cattgttgga    420
 aac                                                                  423



      <210> 1202
      <211> 5088
      <212> DNA
      <213> Homo sapiens


      <400> 1202
 tttcgttgaa aaggaaaaac cagcgttatc caggattgtt aaattaattc ttatctgttt     60
 ccacatcttg gaccgtgatc tctgtggttt taaaatccca tattttgagt gggttccgct    120
 gttgtttaag aaaagttgct ttaaaccttt gctctgcaag cacccgaaga gaactcataa    180
 aaaggaagac aacagcagat gcaatcgcgg atgtggctta gtccttgcag ctgccccaga    240
 gtgctgtttg gagtgtaccg tcctcagtaa tgaatccaga agaacaaatc gtgacatggc    300
 ttatatcttt gggagtttta gagtccccta aaaagaccat ctgtgatccg gaggagtttt    360
 taaagtcctc gctgaaaaat ggggtagttc tgtgcaaact gatcaacaga ctcatgcctg    420
 gctctgtgga aaagttttgt ctggatcccc aaactgaagc tgactgcatc aacaacatca    480
 atgacttcct gaaaggatgt gcaaccctcc aagtggaaat atttgatcct gatgaccttt    540
 attcaggggt caatttctcc aaggtactga gtactctttt agctgtcaac aaagcaacag    600
 aagatcagct atcagaaaga ccatgtggac gttcctcttc tcttagtgct gctaatactt    660
 ctcagacaaa cccacaggga gcagtttcta gcacagtttc agggctgcaa aggcagtcaa    720
 agacagtgga gatgacggaa aatggaagtc atcagttgat agtaaaagca agattcaact    780
 ttaagcagac taatgaggat gaactgtcag tttgtaaggg ggacatcatt tacgtcacac    840
 gagttgaaga aggaggctgg tgggaaggca cattaaatgg gagaacaggc tggttcccca    900
 gtaattatgt ccgtgaaatt aaatccagtg agagacctct ctccccaaaa gccgtcaaag    960
 gatttgaaac tgctccactt accaagaatt attatactgt ggtgttacag aacatcctgg   1020
 acactgaaaa agaatatgct aaagaacttc agtctcttct tgttacttac ttaagacccc   1080
 tgcagtccaa taacaatctg agtactgtgg aggttacatc tttactggga aacttcgagg   1140
 aagtatgcac atttcaacag acactctgcc aagccttgga agaatgttca aagtttccag   1200
 aaaaccagca caaagtagga ggttgtctac tgagtctcat gcctcatttt aaatctatgt   1260
 atctggctta ctgtgcaaac catccttcag ctgtaaatgt gctcactcag cacagtgatg   1320
 agttggaaca attcatggaa aatcaaggtg catcgagccc aggtatcctc attttaacaa   1380
 caaacctcag caaaccattc atgcgactgg agaaatatgt tactctcttg caagagttag   1440
 aacggcatat ggaggatact catccagatc atcaggatat tctgaaagca atcgtagcat   1500
 tcaaaactct catggggcaa tgtcaagatc tgaggaagag aaaacagctg gagttacaga   1560
 tactgtccga acctattcag gcatgggaag gagaagatat taaaaacttg ggaaatgtga   1620
 tttttatgtc acaagtaatg gtgcagtatg gagcatgtga ggaaaaagag gagcggtacc   1680
 ttatgttatt ttcaaatgtc ctgataatgt tatctgcaag tcctcggatg agtggcttta   1740
 tctatcaggg aaaaatacca atagcaggaa cggtggtgac tagattagat gaaattgaag   1800
 ggaatgactg cacatttgaa atcactggta acacagtgga gagaattgtg gtccattgta   1860
 acaacaacca ggacttccag gaatggttgg agcagctgaa cagactgatc agaggacctg   1920
 cctcttgcag ttcattatcc aaaacctcat cgtcatcatg tagtgctcat tcttctttta   1980
 gctctaccgg acagccccga ggacccttgg agcctcctca aattataaaa ccgtggagtt   2040
 taagttgtct acgacctgca cctccactta gaccatcagc agcactaggt tataaagaga   2100
 ggatgtctta tatcttaaag gagtctagta aaagccctaa aacgatgaag aaatttcttc   2160
 ataaaaggaa gactgagaga aaaccatcgg aggaggaata tgtgattagg aaaagtacag   2220
 ctgctctgga agaggatgct caaatcctta aagtgatcga agcctactgc accagcgcaa   2280
 attttcaaca aggccatggc tcaagtactc gaaaagattc cattccacaa gtcctactcc   2340
 ctgaggaaga gaaactcatc attgaagaaa ccagaagcaa cggccagacc atcatggaag   2400
 aaaagagcct tgttgatact gtttacgcct tgaaggacga ggtcagagaa ctgaagcagg   2460
 aaaataaaag aatgaagcaa tgcctggaag aagaactgaa atcaagaagg gacctagaaa   2520
 agctggtgcg gaggcttttg aagcaaacag atgagtgtat tcgaggcgag tccagtagca   2580
 agacctcaat tcttccataa ccatcactgt gccactgggt ggagtgtgcc ttcagggcat   2640
 cttgaaatgt cccgctgaat gatttgactc agtttgctca cttctttggc ttttgttttg   2700
 tgtttgagtc tctctctctc tctccctctc tcttctcttt ctctccccgc tgtgtgcata   2760
 tgtgtgtgcg tgcacgtgcg cgcttgggca tttgctgttg tttggttatt ggttggttgt   2820
 tcattttttt tttcaacagg tgaaaaagca ggaagtggtg gtagagatgg cctcagagtc   2880
 ttttccattc agtaagaaag agaaagggaa tgcaggccag ttacttaaaa ggtcttcaga   2940
 ttgccttcag ttcacagtgc ctctgcaaca gccattgccc tcaggtcaca ttctttgggc   3000
 tggctgccct tgcaaagcag ctggccaagg cttattaaat gtgaacccaa cttttcccca   3060
 gggctttcct gtacctgcaa gcctcttagt acttaattta ccgaaggcaa atcttccaga   3120
 ctatggcttg agtaggatga aagacaaaca catctgccca atgatccagc tgcccttcct   3180
 tagaccatca catgcctccc ctcaatcaca ggttttaaaa ttactgccct atgttgtcta   3240
 taagaccaag aaaactgtag tacccttatt ccttttgtgt catgtaaatt gtaactcagg   3300
 ggggcagaag ctctggtcac ccacaccaac accaaatcca tcagcaaatt ctactggaca   3360
 atcctccctt ttagtagcag agttgaccgc cttttcccat tgcatgatag ggttctttcc   3420
 ctcattctgc ctagtgtgta agttttctat ttccccagta cttttagcca accttaccaa   3480
 gtggtgtgta aactagtatg tatgtgcttt gcttactttt taaaaaaatg tagttagact   3540
 gtgaggagtt actttatgta cgttgcatat tcaaactgtg atgttttatc cttcaaaaca   3600
 atctgcatta agaagatatt gtgccctact agacagcttt ccattcactt tattactctc   3660
 tcatatatgc tgtgagaagt tgtaatatta attggcctct ttgggtggga ctctaagcag   3720
 tatttgcaga aatatgcttc tggtccaact tgtacatcca gaacaaaagg gcccctctag   3780
 tagctgtgtg ctggattatt caggactgat taactcaagt tgctcattga atcacatcat   3840
 ccactttatc ccagaaacta gaactgtgag aaaccaggtt tagaagacag tcacagaaca   3900
 gcacacatcc aaattcagcg ccattgaaag ttggcctaag gctcagtgcc actcacccct   3960
 ccctccccaa aagacaagag aaatttggcc agatggggaa ggtcactgga aattgaggcc   4020
 aaagggctga tcagaattgc ctttataata tatttgatgg atgcctataa atgtgggttt   4080
 tgcaaatatt gtttaaaaac caaacttgaa gccaggcatg gtggcccaca cctgtggtcc   4140
 cagctactca ggaggctgag gtgggaggat catttgagcc caggaggtca aggctgcagt   4200
 gagctgtgat gacaccactg cactccaacc taggtaacag agagacacct ctgtctctga   4260
 aaaaacaaaa cttgaagttt gaaaccccca gcttgctgag gagccctttt tatttttggt   4320
 actgagagtc tcaaggtccc atagctacat ggtacagggc tgttgtctgc ttgctgcaca   4380
 gcagaaatta caccatccac aggaaatgga ctatttttgc agtccaacat cagccaacca   4440
 cacacagccg tgtttggaag ctgaagagta aagaaatttc taggaatggc tgttgttctg   4500
 ttttttagca cagccattta gatataacat ccttcactta aaaattaaaa acatcagtac   4560
 taccaccacc accaacaaca tcaacacaga tcttcacatc tgcccattct gtggttagtc   4620
 aatggcttgc aataaatgtg caaactgcat ctataggaaa catttttgtg attacggaat   4680
 actttagttg attgctgaaa atattgaaag ggcttcattt tacagtgatg agtacatatg   4740
 catgtttcgg ggacttggcc cttctgatga ggggccctcg gtactctgga taacgaagct   4800
 tgtgcagagt ggtaaccatg cttacacact aaactataat ataaaggaaa tgaagccatg   4860
 ttaatctgag agcagtgtcg ccatagttgt gttgtttaca atactctata aatgggttcc   4920
 tgttgccctg taattaaact gctgcccgta gaggcctttc agttcctttt ctgtccttcc   4980
 ccttcttaac acaagctcaa attttctaac ttgtttttat tttgaagact tttaaaatgg   5040
 acattttcaa tacataaaaa taaacagtgc tttataaaaa aaaaaaaa                5088



      <210> 1203
      <211> 468
      <212> DNA
      <213> Homo sapiens


      <400> 1203
 atgagggaca aagggtctca ggaaaggttg caacttgacc caggtcaaaa gctagttgtt     60
 agcatggaca aggctggtgg atttagtttg gagaaggagg tggctggcct ctggatcaag    120
 atcccatgca cagacacatt ggcagctgta cctttgaaca cttctgtgat gtgcttgaca    180
 tgttattcct actggggagc cctgcccaga gcccctgcgt acctatgggc ttcttgccac    240
 tgtcccttca aagaaatttg cccaattaat actagggtta gacagaccaa ggctgagcgg    300
 acagacaggt ctacaaacag tgcccagctc tctgacactt gggagatggc aaacgggatg    360
 atgatctcag ctgggacgtg gaactggagg gcataggtga agaagatgcc gatagagtac    420
 atcagcttga ctgactggta caacctgcag cacatgaatt ggatgtga                 468



      <210> 1204
      <211> 468
      <212> DNA
      <213> Homo sapiens


      <400> 1204
 atgagggaca aagggtctca ggaaaggttg caacttgacc caggtcaaaa gctagttgtt     60
 agcatggaca aggctggtgg atttagtttg gagaaggagg tggctggcct ctggatcaag    120
 atcccatgca cagacacatt ggcagctgta cctttgaaca cttctgtgat gtgcttgaca    180
 tgttattcct actggggagc cctgcccaga gcccctgcgt acctatgggc ttcttgccac    240
 tgtcccttca aagaaatttg cccaattaat actagggtta gacagaccaa ggctgagcgg    300
 acagacaggt ctacaaacag tgcccagctc tctgacactt gggagatggc aaacgggatg    360
 atgatctcag ctgggacgtg gaactggagg gcataggtga agaagatgcc gatagagtac    420
 atcagcttga ctgactggta caacctgcag cacatgaatt ggatgtga                 468



      <210> 1205
      <211> 258
      <212> DNA
      <213> Homo sapiens


      <400> 1205
 atggcccatt acaaagccgc caacttgaag cgtgagcagt tccggaggta cttggagaag     60
 tcaggggtgc tggacacact gaccaaggtg ttgcatcact taggaactgc taccccagaa    120
 aatccagaaa tagagctgct gtgcctagaa ctggcgaaaa cgaaagagaa atataaagct    180
 attgtagaaa aaaataaaaa actgaaagca aagcttgctc agtatgaacc acctcaggag    240
 gagaagtatg ctgaatag                                                  258



      <210> 1206
      <211> 258
      <212> DNA
      <213> Homo sapiens


      <400> 1206
 atggcccatt acaaagccgc caacttgaag cgtgagcagt tccggaggta cttggagaag     60
 tcaggggtgc tggacacact gaccaaggtg ttgcatcact taggaactgc taccccagaa    120
 aatccagaaa tagagctgct gtgcctagaa ctggcgaaaa cgaaagagaa atataaagct    180
 attgtagaaa aaaataaaaa actgaaagca aagcttgctc agtatgaacc acctcaggag    240
 gagaagtatg ctgaatag                                                  258



      <210> 1207
      <211> 2338
      <212> DNA
      <213> Homo sapiens


      <400> 1207
 gcggccgccg agcgcgagct agagctgctg cgcgccagtc tggagcacca gcgcggggtg     60
 agtgagcttc tgcggggccg gttgcgggag ctggaggaag cccgcgaggc tgcggaggag    120
 gcagcggcgg gggcccgggc ccagctacgc gaaggccacc acccagaccc cgtggagctg    180
 tgccgaaaag gccgcgcaga ccgagtcccc ggcagaggcg ccctccttga ctcaggagag    240
 ctcgcccgga tccatggacg gagacaaggg ccgtggcgcc cgcgggcaat cctcaaatcc    300
 atcatgaaga agagagacgg cacacctggt gcccaaccca gctccggacc caagagcctg    360
 cagtttgttg gggtcctcaa cggagagtac gagagctcct ccagcgagga caccaagcga    420
 cagcgatggc gacagcgaga acggtggcgc cgagcccccg ggtagctcct cgggctccgg    480
 ggatgacagc ggcgggggat ccgactcggg cacccctggc cctcccagcg gcggggacat    540
 ccgggaccct gagcccgagg cggaggcaga gcctcagcag gtggcacagg ggaggtgcga    600
 gctgagcccg cgtctgaggg aggcgtgcgt agcgctgcag cggcagctga gccggccccg    660
 cggagtagcc agcgacggcg gcgcagtgcg cctcgtggcc caggagtggt ttcgagtgtc    720
 cagccagcgg cgctctcagg cggagcccgt ggccaggatg ctggaagggg tgaggcgcct    780
 gggacccgaa ctgctggcgc acgtggtgaa cctggcggat ggcaacggga acacggccct    840
 gcactacagt gtgtcccacg ggaacctggc catcgcaagc ctgctcctgg atacgggggc    900
 ctgcgaggtc aaccgccaga accgagccgg ctactcggcc ctcatgctgg ctgcactcac    960
 ctctgtgagg caggaagagg aggacatggc tgtggtccag agactcttct gcatgggtga   1020
 tgtcaatgcc aaggccagtc agacggggca gacagccctc atgctggcca tcagccatgg   1080
 ccgacaggac atggtgggca accctactgg cgtgtggggc tgatgtgaat gcgcaggatg   1140
 cggatggggc cacagcgctg atgtgtgcca gtgagtatgg gcgcctggac accggtgcgg   1200
 ctgctgctca cccagccagg gctgtgaccc ctgccatcct ggacaatgag ggcaccagtg   1260
 ccctggccaa tcgccctgga aggctgaaac aggaatgaag gtggccgctc tgctaacatg   1320
 cccacctgag ctcgggccat cccgacaccc agagcggagt cacccccttg gctccccaga   1380
 cagccaacac ctggtgaagg agaatgcggt gacaaatgga gagaaccccc aggttcagta   1440
 agctgccatc gtcatggctc actacaccta gctgtgggga gatctcctcg tcagtcacct   1500
 cagcctttgg cgcacagaag ggtcccaggg tcccctggct cagaggctaa cactggccga   1560
 cagagaaagg caatttcagg ttggggtgac tgtggcagga acggggctca ctctggcccc   1620
 accaaggtga ggtggggacc caacgtgata gagccctgat ccacccactc tctgaaaact   1680
 tctttgctaa taaaacattc ctactacgct tgtgttttgt ttggggtaga aggtgcaatc   1740
 gaacaaacac gaaccccccg cctcaaaaaa ggaaaagctt cgtttggcaa gaccgcacgg   1800
 cccaggattt ccagagtgcg gaggatcggt gaaccgccct gggagcccac tcaagaaacc   1860
 tggagaaacc ctagtcgtat aacccagaac aagaacctga gttaacttga aaacacaaac   1920
 gctttaattt taaagggagc catctagagt tcacgtgtgg ggggacaaaa aaaaagggac   1980
 caaactgtga caagaccaat tccccatggg gccaaagtgg tcgatccccg acatccaaag   2040
 accccagcga gcgagccaag ctcaacgtgc acaccctccg gggcttctcg ctctgactcc   2100
 aacaagggtg agcacgtcgc cctcgcgcac ggggccattt tacattgcgc atgatggatc   2160
 aggctcgtgt cgtcccatga atttccacgg cgcacctgcg atgcagctgt ccctgagaaa   2220
 acggtcctgc ccaggacctt gggttgaccc tggctcagct tgataggctg cacacgggct   2280
 ggtgtmccat gatggcggcg cggcggcggt ctggcggaga gcgggggggg gggggggg     2338



      <210> 1208
      <211> 380
      <212> DNA
      <213> Homo sapiens


      <400> 1208
 gaaacccaga aaacaaccgt agtttctttg ggtggttttc aaaccacagc tccattgagt     60
 ctgacaagat tgtggagata atcaacgaag aattgtggcc caatcccttg cagttctacc    120
 ttttgagtga aggggctcgt gtagagaaag gaaaggaaaa agaaggcagg caaggtccag    180
 gaaagcagcc aatggagact actcagcctg gggtgagcaa atccaactga tcctgcacaa    240
 gtctccctgc tacctcctgc tgggctgctc ctggttgact acatatttgg ctctctgcct    300
 tctcttcatg ttggcctctg tgtactatag accctttgga ctttagttac aagaatatgg    360
 catttatgat caaaaaaaaa                                                380



      <210> 1209
      <211> 989
      <212> DNA
      <213> Homo sapiens


      <400> 1209
 ggaattcccg ggtcgacgat ttcgtcggga agatggcggc ctccaggaat gggtttgaag     60
 ccgtggaggc agagggcagc gcagggtgcc ggggaagctc gggaatggag gtggtgcttc    120
 ctttggatcc tgccgtcccc gccccgctgt gccctcacgg acccactctt ctgtttgtaa    180
 aggtgaccca agggaaagaa gaaactcgga ggttttatgc ctgttcagcc tgtagagata    240
 gaaaagactg taattttttt cagtgggaag aatgaaaagt tgtcaggagc tagacttgct    300
 gcccgagaag ctcataaccg aaagatgtca gcctcccctg tcccgaacgc agtgtgtgga    360
 aaggtacttg aagtttattg agttgccctt gtcatcagag aaagttttgt caaacatgtc    420
 agcagttgtt gttaccagat gactgggggc aacatagtga gcatcaggtt ctgggtaatg    480
 tgtccattac ccagttaaga aggcccagtc aactccttta tccactggaa aacaagaaga    540
 caaatgccca gtatctgttt gctgatcgga gctgtcagtt cttggtagac ttactttctg    600
 ccctcggatt cagaagagta ctgtgtgttg gaacaccaag gttgcatgag ctgatcaagt    660
 tgacagcatc aggtgacaag aagtctaaca ttaaaagcct tttattggat attgattttc    720
 ggtattcaca gtttttatat ggaagatagc ttttgccatt ataatatgtt taaccatcat    780
 ttctttgatg gaaagactgc ccttgaagta tgcagagcat ttttacagga agataaaggc    840
 gaaggaatca ttatggtgac ggatcctccg tttggtggct tggttgaacc tctggctatt    900
 acattcaaga agttaattgc tatgtggaaa gaaggtcaaa gccaaggtgt ataatttatt    960
 actgcaaaat aaatacatat ctatatatc                                      989



      <210> 1210
      <211> 2066
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2066)
      <223> n = a,t,c or g


      <400> 1210
 ctcagctgcc cccggagcgg ttcctccacc tgaggcagac tccacgtcgg ctggcatgag     60
 ccggcgcccc tgcagctgcg ccctacggcc accccgctgc tcctgcagcg ccagccccag    120
 cgcagtgaca gccgccgggc gccctcgacc ctcggatagt tgtaaagaag aaagttctac    180
 cctttctgtc aaaatgaagt gtgattttaa ttgtaaccat gttcattccg gacttaaact    240
 ggtaaaacct gatgacattg gaagacttag tttcctacaa ccctggcata tttggaaggt    300
 tcctgtaaag actgcattaa agactatgaa aggctgtcat gtattgggtc accgattgtg    360
 agccctagga ttgtacaact tgaaactgaa agcaagcgct tgcataacaa ggaaaatcaa    420
 catgtgcaac agacacttaa tagtacaaat gaaatagaag cactagagac cagtagactt    480
 tatgaagaca gtggctattc ctcattttct ctacaaagtg gcctcagtga acatgaagaa    540
 ggtagcctcc tggaggagaa tttcggtgac agtctacaat cctgcctgct acaaatacaa    600
 agcccagacc aatatcccaa caaaaacttg ctgccagttc ttcattttga aaaagtggtt    660
 tgttcaacat taaaaaagaa tgcaaaacga aatcctaaag tagatcggga gatgcctgaa    720
 ggaaattata gccagaggaa attttagact gcagaatata attggcagaa aaatgggcct    780
 agaatgtgta gatattctca gcgaactctt tcgaagggga ctcagacatg tcttagcaac    840
 tattttagca caactcagtg acatggactt aatcaatgtg tctaaagtga gcacaacttg    900
 ggaagaagat cctagaagat gataaggggg cattccagtt gtacagtaaa gcaatacaaa    960
 gagttaccga aaacaacaat aaattttcac cctcatgctt caaccagaga atatgttatg   1020
 ttcagaaccc cactggcttc tgttcagaaa tcagcagccc agacttctct caaaaaagat   1080
 gctcaaacca agttatccaa tcaaggtgat cagaaaggtt ctacttatag tcgacacaat   1140
 gaattctctg aggttgccaa gacattgaaa aagaacgaaa gcctcaaagc ctgtattcgc   1200
 tgtaattcac ctgcaaaata tgattgctat ttacaacggg caacctgcaa acgagaaggc   1260
 tgtggatttg attattgtac gaagtgtctc tgtaattatc atactactaa agactgttca   1320
 gatggcaagc tcctcaaagc cagttgtaaa gataggtccc ctgcctggta caaagaaaag   1380
 caaaaagaat ttatgaagat tgtgatcttc ttattaaatc aattgttact gatcatgaat   1440
 gttagttaga aaatgttagg ttttaactta aaaaaaaatt gtattgtgat tttcaatttt   1500
 atgttgaaat cggtgtagta tcctgaggtt tttttccccc cagaagataa agaggataga   1560
 caacctctta aaatattttt acaatttaat gagaaaaagt ttaaaattct caataccaaa   1620
 tcaaaccaat ttaaatattt taaggaaaaa gggaaaagta gatagtgata ctggagggta   1680
 aaaaaaaatt gattccaatt ttatggtaaa ggaaacccat gcaattttac ctagacagtc   1740
 ttaaatatgt ctggttttcc atctgttagc atttcagaca ttttatgttc ctcttactca   1800
 attgatacca acagaaatat caacttctgg agtctattaa atgtgttgtc acctttctaa   1860
 agcttttttt tcattgtgtg tatttcccaa gaaagtatcc tttgtaaaaa cttgcttgtt   1920
 ttccttattt ctgaaatctg ttttaatatt tttgtataca tggtaaatat ttctgtattt   1980
 ttttatattn gtcaaagaat atggtctctt gtatgtccat ataaaaataa attttgctca   2040
 atacaattgt aagcttaatg taaaaa                                        2066



      <210> 1211
      <211> 1667
      <212> DNA
      <213> Homo sapiens


      <400> 1211
 tttttttttt ttctatgtac aaaaacattt taattgaaat acctgtataa aaaaatatga     60
 tctccagaca tctcactttt gaactgaaag aacccccatc tgcgatgcct gcacacaccg    120
 cattcacaca aacacaggta ctgaataaat taaacgctca ggctctggcc ccaccccagc    180
 tttcagagcc cacaagcaga ctgtacaaag tcaataattt aaaacccaaa ccctgggcac    240
 agtgcctgga agtgtcaggg tcacccactc cccttaagtt agccactata catgttcatc    300
 ttctgacagg cggggccagg acagacgcca ggcacaggaa tcagggcctg gggtccctgg    360
 accacagcca ccccctcccc tgcctcccca ctgtcccctg gggcttggga gaggcagact    420
 gctcagagga aataacctca acaaataaat taaacaataa atagccccgg tgggccgagg    480
 gcacctccag ggggtcacac cataaataac agagttggcg gcgggtacgg ctcgcgtggg    540
 cgggcgggcg cggaggccag gacttgcatt gtgtgtgcag gacgtgccca gacgcacacc    600
 gcaggactga gggcgggagg tgggcttggg accctgcgcc ggcggaaaga gctccgggtg    660
 ggcaggcaga tgggaaggcc gcctccggac acagcagcac agaggggcgt ctggggttca    720
 agtatccacc cagggcaggc gggacctcga ccggagcgtc tttggacaga cagagcttga    780
 gaaaaccaag tcccgcggga ccagcgttca aaaggcactc aaagcgaagg tcaccagggg    840
 tcagaggtca ctgcttccgc aggaggagac ggcccacgca ggaaaaagtc agggtctggg    900
 ggcgtcccag gtctggccaa ggcaggtggt cccctagctc ccagtcaggt gcagctcctc    960
 acaagctctc gctgctggac gtggtgctgg ccacgtcatc agggtcgagg gtgcacagcc   1020
 gcaggtcaca gctctccggg gcgcccccgt cagcccccag catccaggga tgggccgcaa   1080
 tctgatccag cgacggccgc tctgagggcc gcagggacag gcaccaccgg atcagctgct   1140
 ggcactctgg agagaccctc ctccggaaga gcaggcggcc tcggaggatc tcctcgtcct   1200
 gctcgaaggg gatgtcccca cacaccatat cgtagagaag cacgcccagc gaccacacgg   1260
 tggccgagcg cccgtggtag cggtggtagc ggatccactc cggggggctg tacactcggg   1320
 tgccgtcgaa gtcggtgtag accgtgtcct tgagcagcgc acccgaaccg aagtcgatga   1380
 gcttgagctc tccggagcgc aggtccacaa gcagattttc gtccttaatg tcgcggtgca   1440
 cgaccccgca gctgtggcag tggcgcacgg cggccagcac ctgcgcgaag aaagcggcgc   1500
 gccagcggct cgtccagggc gccgcgctcc gtgataaagt cgaagatggt cctagcgccg   1560
 gctcgggccg ctccagcacc agcaggaagc cgtcgggccg ctcgaaccag tccagcaggc   1620
 ggatgacgcc gcgcgcgccg cccggcgcgc ccaccttgcg cagcagc                 1667



      <210> 1212
      <211> 2948
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2948)
      <223> n = a,t,c or g


      <400> 1212
 cccttacttg tagatgttga tctcagcttg tcagcatatg caatgccaaa aagtattatg     60
 atcacaagag atatgctgct aagaaaacac caaagactgt tgaagctgct gagaaggcat    120
 tcaagtcagc agaaaagaaa acaaagcaaa cattaaaaga agttcagact gttacccnct    180
 attcaaaaag caagaaaagt atattggttg acctgaaata gtagccagcg caccctaagg    240
 gtgaactact gaagagggtg cttaacccat tacttcccta tggaccagct ctcattgaac    300
 actgtctttt agaaaatgga ttctcgggta atgtcaaagt ggatgaaaaa cttgaaacta    360
 aagatattga aaaagtactt gtttctctgc agaaagcaga agactatatg aaaacaacat    420
 ccaacttcag tgggaaggga tatatcattc agaaaagaga aataaaacca tgcttggaag    480
 cagataaacc agttgaagac atactgacgt atgaggaatt tcatcctttc ttgttttctc    540
 aacattcaca atgtccatat atagaatttg aatcatttga caaggcggtg gatgaatttt    600
 attccaagat agaaggccag aaaattgact taaaagcttt acaacaggaa aagcaagcat    660
 tgaagaaatt agataatgtt cgaaaggatc acgaaaacag attggaagct cttcagcagg    720
 ctcaggaaat agacaaactg aaaggagagc tcatagaaat gaacctacaa atagttgaca    780
 gagccattca ggtagttcga agtgctttag ctaaccagat agattggaca gaaattgggt    840
 taattgtgaa agaagcccag gctcaaggag accctgttgc aagtgcaatc aaagaattaa    900
 aactacaaac aaaccatgtt acaatgctgc taagaaatcc atacttgtta tcagaggagg    960
 aagatgatga tgttgatggt gacgtcaatg ttgagaaaaa tgaaactgaa ccaccaaaag   1020
 gaaaaaagaa aaaacaaaag aataaacagc tgcagaagcc tcagaaaaat aagcccttac   1080
 ttgtagatgt tgatctcagc ttgtcagcat atgccaatgc caaaaagtat tatgatcaca   1140
 agagatatgc tgctaagaaa acacaaaaga ctgttgaagc tgctgagaag gcattcaagt   1200
 cagcagaaaa gaaaacaaag caaacattaa aagaagttca gactgttacc tctattcaaa   1260
 aagcaagaaa agtatattgg tttgagaaat ttctgtggtt cattagctca gagaactatc   1320
 taattatagg tggacgagat cagcaacaga atgaaataat tgtgaaaaga tacttgacac   1380
 caggagacat ttatgtacat gctgatcttc atggagctac tagctgtgta attaagaatc   1440
 caacaggaga acccatcccc ccacggacct tgactgaagc tggcacaatg gcactttgct   1500
 acagtgctgc ttgggatgca cgagttatca ctagtgcttg gtgggtgtac catcatcagg   1560
 tatctaaaac agcaccaact ggagaatatt tgacaacagg aagcttcatg ataagaggaa   1620
 aaaagaattt tcttcctccc tcatatctaa tgatggggtt tagcttcctt tttaaggtag   1680
 atgagtcttg tgtttggaga catcagggtg aacgaaaagt cagagtacag gatgaagaca   1740
 tggagacact ggcaagttgt acaagtgaac tcatatcaga agaaatggaa caattagatg   1800
 gaggtgacac gagcagtgat gaggataaag aagaacatga aactcctgtg gaagtagaac   1860
 tcatgactca ggttgaccaa gaggatatca ctcttcagag tggcagagat gaactaaatg   1920
 aggagctcat tcaggaagaa agctctgaag acgaaggaga atatgaagag gttagaaaag   1980
 atcaggattc tgttggtgaa atgaaggatg aaggggaaga gacattaaat tatcctgata   2040
 ctaccattga cttgtctcac cttcaacccc aaaggtccat ccagaaattg gcttcaaaag   2100
 aggaatcttc taattctagt gacagtaaat cacagagccg gagacatttg tcagccaagg   2160
 aaagaaggga aatgaaaaag aaaaaacttc caagtgactc aggagattta gaagcgttag   2220
 agggaaagga taaagaaaaa gaaagtactg tacacattga aactcatcag aacacaagca   2280
 aaaatgttgc ggctgtgcag ccaatgaaac gaggacaaaa gagtaaaatg aaaaaaatga   2340
 aagaaaaata caaagaccag gatgaagaag accgtgaact tatcatgaag ttgctggggt   2400
 ctgcaggttc aaacaaagaa gaaaaaggga agaaggggaa gaaaggaaaa acaaaggacg   2460
 aacctgtgaa gaaacagccc cagaaaccta gaggtggaca gagggtctct gacaacatta   2520
 agaaagaaac tccgttcctt gaggttataa ctcatgagtt acaagacttt gctgtagatg   2580
 atccacatga tgacaaggaa gagcaagatc tggatcaaca gggaaatgag gaaaacctat   2640
 ttgattcttt gacaggccag ccacatcctg aagatgtact actgtttgcc attccaatat   2700
 gtgcccctta caccaccatg acaaactaca aatataaagt gaaacttact cctggagtgc   2760
 agaaaaaggg aaaagctgca aaaacagcct tgaatagttt catgcattcc aaagaagcaa   2820
 cagcaagaga aaaagactta ttccgcagcg taaaggacac agatttatca agaaacattc   2880
 ctggcaaagt gaaaagtgtc tgcacccaat cttctgaacg taaaaaggaa atagctgaaa   2940
 tgaaattc                                                            2948



      <210> 1213
      <211> 2029
      <212> DNA
      <213> Homo sapiens


      <400> 1213
 ggcacgagga gagctagcac catgagcttc ataccctgga gctgcttcag aatccaaaag     60
 aagtgttgac caggagtgag atccaggatg tgaactattc ccttgaagct gtgaaggtga    120
 agacagtgtg ccagatacca ttgatgaagg aaatgctaaa gcgattccaa gtggctgtaa    180
 acctagctga agacacagct catcccaaac tcgtcttctc ccaggaaggg agatacgtga    240
 aaaatacagc atcagccagt tcttggccag tgttttcttc agcatggaac tactttgctg    300
 gatggaggaa tcctcagaag actgcttttg tagagagatt tcagcactta tcctgtgttc    360
 tgggaaaaaa cgttttcacc tcagggaaac attactggga agttgagagt agagatagtc    420
 tggaggttgc tgttggggtg tgtcgggagg acgtcatggg aattactgat cgttcaaaaa    480
 tgtccccaga tgtgggcatc tgggcgattt attggagtgc tgctggctat tggcccttga    540
 taggcttccc tggaactccc acccagcaag agccagctct ccaccgagtg ggggtttacc    600
 tggatcgtgg gactgggaat gtctccttct acagcgctgt ggacggagtg cacctgcaca    660
 ccttttcttg ttcttctgtc tcacgcctcc ggccattttt ttggttgagt ccattagcat    720
 ctttagtcat tccaccagtg actgatagga aatgaggctt ttcttcccct gaccaaaact    780
 ccttccctgt agtccagctg agggacacac atccctgggc cctcttctgc ccttcatgtc    840
 tctatcctgg atggtccatc ttctgggtct ccctaacggt accgtttggt atctgccctt    900
 tgtgtgcttc acaagaggca gtcccatggg aggtgggtct ggccaatgga gatgggacag    960
 gaaattttcc aagacgcttt tgggaaatct ttttgtagct tttaaagaga tgtgcgggga   1020
 agacatatgg atgttagcag ccatattgga actgagaaca caggaatggt ggaaaggtag   1080
 aagaaacaga gtttttgttg ccgttgtgaa attgttgaaa tttccttcat gccaagcttc   1140
 ttgttatatg agataattac gcccttattg tataagacaa ttttagttgt atttggttac   1200
 ttgcagcctg aagtaccgta actgcactaa agggacgtag tgtgaacatc ccgcagtata   1260
 ggcttaagtc acttttgtga aatttgacaa aggcatagaa tctttttcta tccagtcagg   1320
 cattgcctat tctttccagt aactactgat tcccccactt ttctgtctta gaaaattgtg   1380
 ggaatccccc ctcactctgc ctatgttgca ctctctctct tcccaaccat aactctgccc   1440
 tcagctatta actgtgctgt gtatttatca agttggtatg ttgtatgtac agtgttattc   1500
 atgtcatcat gagaatgttg aacgcttgtt aaataccttt tgctagcctc ttcatatgct   1560
 gttgcatatg actctcatca caactcagtg agatggaaag tcaaatccta tttgtacaaa   1620
 tgagaaaact gaactcttta gagtaactag ctcagtattg gccagctggt aaatggcagt   1680
 gttgggatta aaatccagtt cttatctact ctccctttat tcagaagcat ttattggatg   1740
 ttgatctttg tttcaggttt tgattttgtt acttttttat actgtgtata ttttcctcag   1800
 tctacccttc tgctctagat tgtctggact caggagattg tggcagttac tggatagtta   1860
 tttttaagat aatgattgct tttctctgtt tatataagtc atgtgtactt attgtagaaa   1920
 gtttgtaaga tgcaaaaagt ataaaaatta aagttatgca ctactaacat ttcaatatat   1980
 tttctcccag attttcaata aagactttca ggcagtgaaa aaaaaaaaa               2029



      <210> 1214
      <211> 1037
      <212> DNA
      <213> Homo sapiens


      <400> 1214
 gccttttcct ctcccaggtg cgcttccctg cttgatctgt gtaccctgct ctttctcctt     60
 cattccgcag cctcctttgc cctgtgacct gcaggtactg gacggtccct agagaggata    120
 ccgggacgct cctgaagccg cgagatgatt tcaagcagat gcagcctgac cattagggcc    180
 aaggccaaat tgcaaaaaaa aaaaaagttg gcctttattc tactccatcc acatctaaac    240
 tttggaggcc agggctgggg acagatcaaa aaacatagtt ccctccttct ggggctccac    300
 atccttcatt cactgatctt tggaaaggag gatgggtggc aggatgggtc ttccatgata    360
 ctgaagggag agccacatgt tgatgcccag gaccagctgc ctccttggtc tgaaaggcct    420
 gatcgaggcc aggattggct atgagagctg ggaaatggga ccatctttga agccatggga    480
 gagggtgaga gccaccatca ctcatgttct tgaatgggaa ctgcctggag accctgaaga    540
 agaaggagcc tgaaggagga aggaggaggc tgagccatcc cgggaacatg ggctggatga    600
 ggccaagcca ggagacgaca ccaccagata gaagtcacca ttcaggattt ggacttttct    660
 gtggagatcc tggccccgag atcgaaccct tctccctgtg ggtgttcccg caggagatgg    720
 tgctggagat ccaccagctg ttcatggacc atgaataccc atgtcaccac atcacttctc    780
 actgcacctg ggtggcagca cactggacca cgtctcagag ctgcgcagca tggcagggct    840
 gcaggcgggc ttgctgctcc acgtggtgga agagccctgc acaatgcaca aggcccacgg    900
 tgatgagtgc cacatttgag actgctcagg agcctggacc cagctgatgc agctccttgt    960
 ccttcctgag cgtcttcact gacagaggcc tgagagacgg caggagcaga aagacttgga   1020
 gatggacccc accgact                                                  1037



      <210> 1215
      <211> 816
      <212> DNA
      <213> Homo sapiens


      <400> 1215
 ccatggcgac gcgggacgcg gcggtggagg cggttgctac ccacttgcta gaggcgctgc     60
 gggtgtgatc caggctgggg cgagaccatg tcggacctgg gctcggagga gttggaggag    120
 gagggagaga atgatattgg ggaatatgag gggggtcgga atgaggcagg cgaaaggcac    180
 ggacgtggga gggcacggct acccaacggg gacacctacg aagggagcta cgaattcggt    240
 aaaagacatg gccaggggat ctacaaattt aaaaatggtg ctcgatatat cggagaatat    300
 gttagaaata aaaagcacgg tcaaggcact tttatatatc cagatggatc cagatatgaa    360
 ggagagtggg caaatgacct gcggcacggc catggcgtat actactacat caataatgac    420
 acctacactg gagagtggtt tgctcatcaa aggcatgggc aaggcaccta tttatacgcg    480
 gagacgggca gtaagtatgt tggcacctgg gtgaacggac agcaggaggg cacggccgag    540
 ctcattcacc tgaaccacag gtaccagggc aagttcttga acaaaaatcc tgttggccct    600
 ggaaagtatg tatttgatgt tgggtgtgaa caacatggtg aatatcgttt aacagatatg    660
 gaaagaggag aagaggaaga ggaggaagaa ttagtaactg ttgttccaaa atggaaagct    720
 acccaaatca ctgaattggc cctgtggaca ccaactctcc ccaaaaagcc gacctctacg    780
 gatggacctg gccaagacgc tccaggagct gagagg                              816



      <210> 1216
      <211> 816
      <212> DNA
      <213> Homo sapiens


      <400> 1216
 ccatggcgac gcgggacgcg gcggtggagg cggttgctac ccacttgcta gaggcgctgc     60
 gggtgtgatc caggctgggg cgagaccatg tcggacctgg gctcggagga gttggaggag    120
 gagggagaga atgatattgg ggaatatgag gggggtcgga atgaggcagg cgaaaggcac    180
 ggacgtggga gggcacggct acccaacggg gacacctacg aagggagcta cgaattcggt    240
 aaaagacatg gccaggggat ctacaaattt aaaaatggtg ctcgatatat cggagaatat    300
 gttagaaata aaaagcacgg tcaaggcact tttatatatc cagatggatc cagatatgaa    360
 ggagagtggg caaatgacct gcggcacggc catggcgtat actactacat caataatgac    420
 acctacactg gagagtggtt tgctcatcaa aggcatgggc aaggcaccta tttatacgcg    480
 gagacgggca gtaagtatgt tggcacctgg gtgaacggac agcaggaggg cacggccgag    540
 ctcattcacc tgaaccacag gtaccagggc aagttcttga acaaaaatcc tgttggccct    600
 ggaaagtatg tatttgatgt tgggtgtgaa caacatggtg aatatcgttt aacagatatg    660
 gaaagaggag aagaggaaga ggaggaagaa ttagtaactg ttgttccaaa atggaaagct    720
 acccaaatca ctgaattggc cctgtggaca ccaactctcc ccaaaaagcc gacctctacg    780
 gatggacctg gccaagacgc tccaggagct gagagg                              816



      <210> 1217
      <211> 378
      <212> DNA
      <213> Homo sapiens


      <400> 1217
 ttcgtatttc agataaagta gtgggcattc tcatgcgtgc caggaaacat ggactggtag     60
 actttgaagg agagatgcta tggcaaggcc gagatgacca tgttgtgatt acgctactca    120
 agtgaacctt caaaaacaaa agccaaattt ggcccactat ggtcttaatg ctaaatgctc    180
 atgtaggtaa aatgaaaatg caaactctct gtaataagtt agtaaatatt aaacaatttt    240
 tacataaacg actttctggc attctatttc tatctagaat gaggaatttt ggagattttg    300
 agaaggcaca aagcatttca gaaagcacat agaatgttaa tgtataataa tagtattaat    360
 agttgaaatt ccacaggg                                                  378



      <210> 1218
      <211> 1951
      <212> DNA
      <213> Homo sapiens


      <400> 1218
 ccacccctcc accaccaccc cctgccccac ctgcccagct gccctgccca cagtgctcca     60
 agtcctttgc ctcagcttcc cggctgtccc ggcaccggcg tgcagtacac gggccccctg    120
 aacggcgtca ccgctgtggg gtttgtggca agggcttcaa gaagctgatc cacgtgcgca    180
 accacctgcg gacacacacg ggtgagaggc ccttccagtg ccactcatgt ggcaagacct    240
 ttgcttcttt ggccaacctc agccgccacc agctgaccca tacgggtgca cgtccctacc    300
 aatgcctgga ctgtggcaag cgcttcacac agagctccaa cctgcagcag caccggcggt    360
 tgcacttgcg gccagtcgcc tttgcccgcg ccccccgcct ccccatcact ggtctctaca    420
 acaagagtcc ctactactgc gggacttgtg gccgctggtt ccgcgccatg gcgggcttgc    480
 gactgcatca gcgggtccat gcccgagctc ggactttgac gctacagcct cccagatcac    540
 catctcctgc cccaccccca cctccagagc ctcaacagac tatcatgtgc acagagctgg    600
 gggagaccat cgccatcatt gagacatccc agccactggc gcttgaggac accctgcagc    660
 tgtgccaggc tgcactgggg gccagtgaag caggcgggct cttgcagttg gacacggcct    720
 tcgtgtgacg cagctgaaaa gcaacaacaa aagggtttgg ttgcaacagc cagtgtgggt    780
 acctctgggg agagaggacc tcctctgaca aactggtctg gtacccacca tgtgccagga    840
 tccaccctgg cctcttttta cccactgact ccccagaaca acccttccag gcttctcttg    900
 tcatctttct ctgcctgagg ggaaactgaa gctctgaaat gcgatgtgat ctgtaccagg    960
 tcacccagct atgctgcaaa gtgggttggc caaggccctt tgcactgcat caccctggtg   1020
 cccagcaaca tcaggtaacc ttcactgagc accaagctta tgccaggtct gtgctggcca   1080
 ctctcatata cctcttcaga tcctctgctt gtacccccag cccttgcctt ccctggattt   1140
 tgggcaccca ggactttgct ctgcctggtg gagggtactt gatttctctg ggcttccttc   1200
 atctcaattc tgacagtgtg gaaggaaatc tgtaggtacc caggtcctca gctccagact   1260
 gggtgatgct ggagacccag gagcaagtca gcacaggctc tgcccacagg aggcatgcac   1320
 aatctggtag gagaaacgca caagtacaga tagcttgctc tctgagtgtg tctcattgat   1380
 tcattcagcc tgtgtgtcct aaagcctccc ttctcccata ctgggtgatg ctgggggcag   1440
 agatgagtca ggcctaaagc ttctctgggc tgtgatgggg atgtgcaggg acagtgggat   1500
 cccaggaaac agacctccat ggtgggagat cacgagttaa ggacttccta gagaaggtag   1560
 tccctgaagg aaaagtagga atctggcagt gaaagaggaa aagaacattc caggcagaca   1620
 gcactgcaag agggtgagct cttggtgtat ttggagacca tccagttatt catctgactg   1680
 cctacctgag gcaagcacca cacttaccac tgtatgtgta ctatgatccc aacaggcttg   1740
 tgacatagat ttcatattat ccctgttgta tagattttta aaactggtgg ctgggcgtgg   1800
 tggctcacgc ctgtaatccc agcactttgg gaggccgagg cgggcagatc acgaggtcag   1860
 gagatcgaga ccatcctggc taacacggtg aaaccccgtc tctactaaaa atacaaaaaa   1920
 ttagccagga gtggtggcgg gcgcctgtgg t                                  1951



      <210> 1219
      <211> 434
      <212> DNA
      <213> Homo sapiens


      <400> 1219
 cactggaaaa taggctgggt taggggggtg ctgaaagttc cagcctccaa agcaaactta     60
 tagtatggct gtgtgttgcg tgggatgctg gtggcagctt tgtcagacac agatcatggg    120
 tcttgctcca gaatccattg ggctgccaag tgactctttg aagatctgtc tgtaatgtgt    180
 gagtcttgtc catctgctct tgactctgag ctggctaggt gactgttggt tattcctggg    240
 acaggtgctg ggtaggccag gtttcagcat cgcagacaag aagcgcagga caggctgcat    300
 tggggccaaa cacagaatca gcaaagagga ggccatgcgc tggttccagc agaagtatga    360
 tgggatcatc cttcctggca aataaattcc cgtttctatc caaaagagca ataaaaagtt    420
 ttcagaaaaa tgtg                                                      434



      <210> 1220
      <211> 521
      <212> DNA
      <213> Homo sapiens


      <400> 1220
 gggtcgaccc acgcgtccgc ggacgcgtgg gggacccgcc aacatgggcc gcgttcgcac     60
 caaaaccgtg aagaaggcgg cccgggtcat catagaaaag tactacacgc gcctgggcaa    120
 cgacttccac acgaacaagc gcgtgtgcga ggagatcgcc attatcccca gcaaaaagct    180
 ccgcaacaag atagcaggtt atgtcacgca tctgatgaag cgaattcaga gaggcccagt    240
 aagaggtatc tccatcaagc tgcaggagga ggagagagaa aggagagaca attatgttcc    300
 tgaggtctca gccttggatc aggagattat tgaagtagat cctgacacta aggaaatgct    360
 gaagcttttg gacttcggca gtctgtccaa ccttcaggtc actcagccta cagttgggat    420
 gaatttcaaa acgcctcggg gacctgtttg aattttttct gtagtgctgt attattttca    480
 ataaatctgg gacaacacgg acgcgtgggc ggacgcgtgg g                        521



      <210> 1221
      <211> 4424
      <212> DNA
      <213> Homo sapiens


      <400> 1221
 cgcccccccg cttccccgca cgcgctctcc agccgcggcc gcccgcctgc cgcggtcacc     60
 ccggcctctg cctctgtccc ccagtgatcg gatcaaggcg ctgagcgagg ccctgcctgc    120
 ggggcggcca tgcggcggtg acaggagcgc gaccgacacg cacgggcccc tcgccccctc    180
 tcgcctcccg tccgctcgcc agctcccctc agccgaggct gctccgcggc ggccgcagcc    240
 cgcgcgcggc ccacactcgc ctcccctcgg cacccccggc cccggagctg cctggaggcg    300
 gccgcactcg gggatcatgg cccaagttgc aatgtccacc ctccccgttg aagatgagga    360
 gtcctcggag agcaggatgg tggtgacatt cctcatgtca gctctcgagt ccatgtgtaa    420
 agaactggcc aagtccaaag ccgaagtggc ctgcattgca gtgtatgaaa cagacgtgtt    480
 tgtcgtcgga actgaaagag gacgtgcttt tgtcaatacc agaaaggatt ttcaaaaaga    540
 ttttgtaaaa tattgtgttg aagaagaaga aaaagctgca gagatgcata aaatgaaatc    600
 tacaacccag gcaaatcgga tgagtgtaga tgctgtagaa attgaaacac tcagaaaaac    660
 agttgaggac tatttctgct tttgctatgg gaaagcttta ggcaaatcca cagtggtacc    720
 tgtaccatat gagaagatgc tgcgagacca gtcggctgtg gtagtgcagg ggcttccgga    780
 aggtgttgcc tttaaacacc ccgagaacta tgatcttgca accctgaaat ggattttgga    840
 gaacaaagca gggatttcat tcatcattaa gagacctttt ttagagccaa agaagcatgt    900
 aggtggtcgt gtgatggtaa cagatgctga caggtcaata ctatctccag gtggaagttg    960
 tggccccatc aaagtgaaaa ctgaacccac agaagattct ggcatttccc tggaaatggc   1020
 agctgtgaca gtaaaggaag aatcagaaga tcctgattat tatcaatata acattcaagg   1080
 aagccaccat tcttcagagg gcaatgaagg cacagaaatg gaagtaccag cagaagattc   1140
 tactcaacat gtccctttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200
 atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260
 tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320
 atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380
 aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440
 aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500
 gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560
 aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620
 taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680
 gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740
 ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800
 gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860
 aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920
 gaacgaatac accagtcaag gaagattgga atgtcagaat taccaagcta cggaagcaag   1980
 tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040
 taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2100
 ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2160
 ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2220
 ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2280
 ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2340
 atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2400
 agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2460
 agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2520
 tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2580
 ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2640
 tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2700
 ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2760
 atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2820
 ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2880
 tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   2940
 ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3000
 tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3060
 ttatcaaatt cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg   3120
 atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   3180
 ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag   3240
 accccacgtg gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt   3300
 ttcggacctg ttactacccc aagctgtgta atatacttgt ataacagaaa taccttctat   3360
 acaaaccttt ttttctactt ttagatagaa atgtctactt tttcagcagt tctgtgaatt   3420
 aaagagcaga gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt actatcagga   3480
 ttttacagca atgctgggaa atgacaggga aaatgacagg aatgaatctc accagatttt   3540
 ttatgtactc agcagagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct   3600
 cctacttctc ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt   3660
 cagttcttta gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg   3720
 ctctccttaa tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa   3780
 gctatctctc atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca   3840
 cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc   3900
 tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg   3960
 gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg   4020
 cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc gtggccggca   4080
 ttatttccta gttcttcttg taaccctgag gtgccagcgc ggggagtgag gaggggtcag   4140
 ggggctaagg atgcaacctc tgacgttctg cgccttccta ggagagtctt acatgtgttg   4200
 agatttcaca agcaatgcga gttgtaaaat accagctcta caagaagcta ggctctgtga   4260
 cggcatagtt ttcagtagct ttatcacaat attcacaatg gagaattata tgacatggta   4320
 gcagaaatag gcccttttat gtgttgcttc tattttacct caaattgtag atatagggta   4380
 atcaataaaa tccatccatg cctttcacac actaaaaagt cgga                    4424



      <210> 1222
      <211> 964
      <212> DNA
      <213> Homo sapiens


      <400> 1222
 gtccagtgtg gtggaattcc cgggagcctc ctcaggctcc ctctattaaa gccgatctga     60
 ctccgcccag ccagatgtcc cgagtgcgcc aaggactgtc ctctcaccca ctcctggatt    120
 ctgccctgac ctccatcctg gacactgcct tgataacata gacccttcca ctgacaccct    180
 cgctctcaca ccccctccag ctttccgacc ccacaccgac aactccccgg cttccagacc    240
 ctaccagcac taccctaacc ctcagccgac agtctcagcc ccaccgaccc actttcttgg    300
 catatagccc cacttaagac ccctcctcta cttccttctg agtcctctac aaagacatcc    360
 gggtactaca tttccatccc ttccctattt tgacaccaaa ttatggtgta gacagccctc    420
 ccccaacccc aggccagtca ggcacaatcc ccccaccccc caaacgtcct ggactgcaca    480
 gacctcccac tccagaccat ccaggcctgg ttcccaagac ccgatccttc ccctgcaacc    540
 agacagtcta caactgcccc ctccagccca ttttctgccg tgaaacccca gccagccaca    600
 ccagactctg gaaccctttt tcgactgccc caactcttgg acaccaggcc aactagaaca    660
 cccaacacca aactgtacag actctcccac cccaacctcc ccagactctg cacggatgtc    720
 ctaggccccc tccccaactc taaccagacc ccatccccct aagtcccttt gtcttgaccc    780
 ccaagtcttc aaccaagata tcctcggcaa ccccacctcc caccctcctc ctctttctcc    840
 tttcaaagac ccaactgagc acccgctctg attccccaca gcctttctcc ctgggcacca    900
 ctcccttagt ctttcccagg cttactctcc cgaataaatg tgctaggagc tctgaaaaaa    960
 aaaa                                                                 964



      <210> 1223
      <211> 478
      <212> DNA
      <213> Homo sapiens


      <400> 1223
 ctttctgggt ctacccacgc gtccgagctt acacaaaata tatttatgtc aatctggcta     60
 cttttctagt atgttcagtg gttcttggaa agaatccagc atgaatatta ttgaactgga    120
 gattcctgac cagaacattg atgtagaagc actgcaggtt gcatttggtt cactgtatcg    180
 agatgatgtc ttgataaagc ccagtcgagt tgttgccatt ttggcagcag cttgtttgct    240
 gcagttggac ggtttaatac agcagtgtgg tgagacaatg aaggaaacag ttaatgtgaa    300
 aactgtatgt ggctattaca catcagcagg gacctatgga ttagattctg taaagaaaaa    360
 gtgccttgaa tggcttctaa acaatttgat gactcaccag aatgttgaac tttttaaaga    420
 actcagtata aatgtcatga aacagctcat tggttcatct aacttatttg tgatgcag      478



      <210> 1224
      <211> 1631
      <212> DNA
      <213> Homo sapiens


      <400> 1224
 ccggccgtcc cgggtcgacg atttcgtgcg gaagcatcca tggcggaggg cggcagccca     60
 tacgggcggg cagggccggg ctccgcaggt caggtcgtaa tctgaaggag tggctgaggg    120
 agcaattttg tgatcatccg ctggagcact gtgaggacac gaggctccat gatgcagctt    180
 acgtcgggga cctccagacc ctcaggagcc tattgcaaga ggagagctac cggagccgca    240
 tcaacgagaa gtctgtctgg tgctgtggct ggctcccctg cacaccgttg cgaatcgcgg    300
 ccactgcagg ccatgggagc tgtgtggact tcctcatccg gaagggggcc gaggtggatc    360
 tggtggacgt aaaaggacag acggccctgt atgtggctgt ggtgaacggg cacctagaga    420
 gtacccagat ccttctcgaa gctggcgcgg accccaacgg aagccggcac catcgcagca    480
 cccctgtcta ccacgcctct cgcgtgggcc gggcagacat cctgaaggcc ctcatcaggt    540
 acggggctga tgttgacgtc aaccaccacc tgactcctga tgtccagcct cgattctccc    600
 ggcggctcac ctccttggtg gtctgcccct tgtacatcag cgcagcctac cacaacctcc    660
 agtgcttccg gctgctcctc ctggctggcg cgaaccctga cttcaactgc aatggtcctg    720
 tcaacacaca gggattctac aggggctccc ctgggtgcgt catggatgct gttctgcgcc    780
 acggctgtga ggcagccttc gtgagcctgc tggtagaatt tggagccaac ctgaatctag    840
 tgaagtggga atcgctgggc ccagagtcga gaggaagaag aaaagtggac cctgaggcct    900
 tgcaggtctt ttaaagaggc cagaagtgtt cccagaacct tgctgtgtct gtgccgtgtg    960
 gctgtgagaa gagctcttgg caaacaccgg cttcatctga ttccttcgct gcctctgcca   1020
 gaccccataa agaagtttct actccatgag tagactccaa gtgctgcggt tgattccagt   1080
 gagggagaaa gtgatctgca gggaggtgga caccgagccc tgagtgctgt gctgctgctg   1140
 gtctcctgat ggctgttgct gcagaagatg tcctcgtaga ctgtcattgc tcctcacaca   1200
 catgaagacg tgcccgcttc ccctttgctt tctgccatga ttgtaagttt cctgaggcgt   1260
 ccccagccct gcagaactca gcccgggggc acaggcacgc agaagagact ttcccacagc   1320
 ggttcccaga gccctggatg aggcgtcctc caaaggatta tgtcaccaag tttctgcagg   1380
 tgggcacggc ctgacgactg gattgtccaa caaaacacag aaagtgtaga caagagaaca   1440
 gcagaaagtg acgcctgcag ccacagagat gtgctcccag tctccctctt ttctgactgc   1500
 tgggggtgca caccacagcg aggcccaagg gctgtgatgg aggcctagga tggaaggtgg   1560
 ctggtccctg aattacttct aggagaggca ccatctgctg agcaggaacc cctgcctggg   1620
 acagttgcaa g                                                        1631



      <210> 1225
      <211> 1432
      <212> DNA
      <213> Homo sapiens


      <400> 1225
 aaggggcctg gaggatatag ttctggtcct gctgggagac acgagggtca caggcatgga     60
 gaatggagat ggagggggag cccggtccgt gggccccaag agccgagccg gacgagggat    120
 ggagtgggga gacgcaggag ggcggtgtct agggctgggg aatggagtcg tgtctggcac    180
 cccggtgggg actgtattgg aaggcagccc agaatgggca gcggcgagga gtgaacacct    240
 ggctgcaggt gacggcctgc aggaaggagg cgaagatggc cccagggaac caaagaggct    300
 ttgccgaccc ccgggagagg aggaggtgga ctgggaaccc ctggccaaat tccgagcagc    360
 ctgcgggcca gagctggcag acctggtggc tgaggagttg gcctttgcta ggcagcatgg    420
 gacccggggt ttccactgga ccggagctgg ctttgccctt aaggacggca cctcggactt    480
 cttcctggat ggggccctga cacgctgcag ctgctcaatt cacgccgccc gccgtctgcc    540
 ctgcatgaca cctctttgca gcgcgcctcc tcactggggc tgccttattc cacatggacc    600
 tgctcaggga ttgctggggg agagccccag agccctgacc cttcatgcct ctgcccacca    660
 ccctccacca ggagggtcgg agggcattct tcgatcccaa agataatagg gctgaggcca    720
 aggagaccgt tgcagtcccc ctggccacct tctgggtcat ccagggacct cctcatggca    780
 gtttgcctct ctgggtccaa gggcaagctg taagtggtct ctgaggtcct ggagccacag    840
 cttgggaagg tgttgatggg cagggtggat tctgagggct tccctctgga gaggaagcat    900
 gtgatgagag gtgtagacag ggtcaggctg ggacagaagg aaggaaaggg gcagagctgg    960
 ggggaggggg aggaagcgat catatgggga gtgtctggca agagtagact ggccagtcta   1020
 gggagtgcag cggggagagg ggaaagggag aaagtacaga agacagatga aggagaggag   1080
 gtaagcgaga aaaaatggaa aggggagccg gaaatggagg agagaggaca agcaaagaga   1140
 cagaaatgaa gacatgagga aaagctgggg gaagcaggag aggaagggac gggatgtagg   1200
 agggggaaga aaaatcggag atgagacaaa agaaatgtgt gggagacggg tagagacgaa   1260
 atgcaagggg cgtggttttg gtttttctcc aagacctgga gacatcgacc cccatcgcct   1320
 tctgaagaga gagggagggc gggcactggg ggtcaggaga gtctccagca ggggagggga   1380
 attgtttgga ctattgttct tcaggattgg aataaaacaa tcttaatttg ga           1432



      <210> 1226
      <211> 638
      <212> DNA
      <213> Homo sapiens


      <400> 1226
 tttttttttt ttgtgtgcca caagtttatt actcaataaa tattctgtgg tttgacgtgc     60
 tgtattgtat ttttaatgta tcctgatgag aaaaacaatc ctaagacatc ctgtaagtat    120
 cagacacgat tgaataagaa ggggaatgac tccatgaaac tatatttggc atcagtaaga    180
 ttcttctgcc agttttctcg aaagcgaacc attcctggtc tgtgaactaa tgcttggtgg    240
 tcacctacat aagaaacaac aatgggtgca tccgaaaaat attcgtcaat ttgtttaaga    300
 cccttttcca cagtgaattc accgtgagtc atccacttga tgtttttcaa agggtttcgc    360
 tcctcttcca caatcttaac agcataattg atgacatcct caaccagagc tagagctact    420
 tgagtcaatt catcctcgta gttcttgtct tgtgtattcg gcattgtttg gcttgcggct    480
 ttgttatcct catccattgc tttctggctt gttgaatttt gagtctcact cattttcttt    540
 ttccggagtg agcagatctt ctttgcttgg aacaggagca gtggtaggtg gctggggatg    600
 tctcaggatt ctctcagtag cttctctcag attgccag                            638



      <210> 1227
      <211> 1477
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1477)
      <223> n = a,t,c or g


      <400> 1227
 tttttttttt ttgacggtct tcaggtttat ttcttaaatc aattaggaaa taaaaccaca     60
 gtgcccagga aagttcacat gagacgccac ggtgtctctt gccatggccc caccactcca    120
 ggggccaggg ggtgctgctg gagggaggac agacggacag gcggcctggg tggccggccc    180
 cagaaaggct ggcgtggatg ttcgagatga gccaccagcg aagccagtag ggatgtctgg    240
 gccgtcctgg tgggattgtc tgggacatcg ccaccaacac ggtgtcagag ccatcagtgg    300
 ggacatcgga ggggccacca ccaggtgggg tatattcaac aggctagaac ccctgaggct    360
 tgagaggcca acccccggca ggagacctcc cctgacccct ctgctgcctc tcctgtggga    420
 ccctccagta gacacaccag atgaggacac ccaggaggcc tcctcccagg acaggaggca    480
 gctggctggg cagccacgca gtgcagggtt cagggccctc cagcaggagc tccatggaga    540
 tggctaaatg gggacatcaa ggcaggggct gacagtggtg acatccaagt ggtcacagtc    600
 aattccggaa gctttcaggg catcaggagg ggaaggtggg gctggggaaa tgtgacagga    660
 acggggaagt gcaaaaggca attggcctag cctgggagat tttccagttg gcctggggga    720
 cccccggctc ctccattcag cagggagggc ggagggcctg cttggaagtc acatggagct    780
 gcagcatctg gaacccaaca gccacaggag gcctggatcg gggctccgta aggcacagcc    840
 gagagggagg tggggaggcc ccagtccgag tccagggccc aggggagatg attcctgcag    900
 tccccaaaag cagctggacc ctacacaaga tgcagctccc aggacacgcg tgttccactc    960
 tcggcaggag aggagaggaa aaaggaaagg ccgggccaga ggctcacgcc tataatccca   1020
 gcactctggg aggccgaggc cagcggatca cctgaggtca ggagttcaag accaacctga   1080
 ccaacatggt gaaaccccgt ctctactaaa aatataaaaa ttagctggac gtggtggcgg   1140
 gtgcctgtaa tcccagctac tcaggagggt gaggtgggag gatcccttga accccaggag   1200
 gcagaggttg cagtgagccg agattccccc cctgcacttt aggccgggca gcaaagtgag   1260
 actttatttt taaaaaaaaa gaaagaaaga aagaaaagaa aaagagggaa gagttaaggc   1320
 cagacaggga cagggatgga aggagccaga ggctgaaaag cagggagagg aggcagacac   1380
 aggggcacca aggcagcaga gaggcacggg ttcctctgag gttccagttt ctcgnngtcc   1440
 nccgcnaggg ctntaggtca tcaatnnggn cacgcct                            1477



      <210> 1228
      <211> 639
      <212> DNA
      <213> Homo sapiens


      <400> 1228
 gcggccgcgg cgcgagccgg gacccctgga agggtcgggt gcgcggccca ggaggtaccg     60
 ctgtctcctc acaatcggcc aggcctgcag ccgctgccgc cgccgccgcc gccgccgccc    120
 tactcaggga gtggcccagg cctgcggcgc gccaccctca cctccttcat tcctaccgtc    180
 aaagcccagc cttggctacc tgacccccct gtggtctcga actcggttag tccggtgaag    240
 ggacagagaa gcctgggttc ccggcggcat cactgagatg ctcagtcctg aattctgccc    300
 tccattagga ttatctgctt tgtgggataa tttcctcatt ggttgagtca gtgagttgcg    360
 tgtctgcaag agagcatcct atctggtcgg agcagagcat ggacatggga acgagtgctc    420
 tcagcaagaa gccgcggggg acccttgcct aaaaaacttt atgcaccaat ggtgtttcac    480
 atggaagagg accaggagga gctcatcttc gggcatggtg acacatacct tcgctgcatt    540
 gaggtgcaca gccacaccct tattcagctg gagagttggt tcacagctac aggccagact    600
 cgtgtgactg tagtcggacc acacagggca aggcagggg                           639



      <210> 1229
      <211> 2068
      <212> DNA
      <213> Homo sapiens


      <400> 1229
 atggccgagg ccgcggagcc ggagggggtt gccccgggtc cccaggggcc gccggaggtc     60
 cccgcgcctc tggctgagag acccggagag ccaggagccg cgggcgggga ggcagaaggg    120
 ccggagggga gcgagggcgc agaggaggcg ccgaggggcg ccgccgctgt gaaggaggca    180
 ggaggcggcg ggccagacag gggcccggag gccgaggcgc ggggcacgag gggggcgcac    240
 ggcgagactg aggccgagga gggagccccg gagggtgccg aggtgcccca aggaggggag    300
 gagacaagcg gcgcgcagca ggtggagggg gcgagcccgg gacgcggcgc gcagggcgag    360
 ccccgcgggg aggctcagag ggagcccgag gactctgcgg cccccgagag gcaggaggag    420
 gcggagcaga ggcctgaggt cccggaaggt agcgcgtccg gggaggcggg ggacagcgta    480
 gacgcggagg gcccgctggg ggacaacata gaagcggagg gcccggcggg cgacagcgta    540
 gaggcggagg gccgggtggg ggacagcgta gacgcggaag gtccggcggg ggacagcgta    600
 gacgcggagg gcccgctggg ggacaacata caagccgagg gcccggcggg ggacagcgta    660
 gacgcggagg gccgggtggg ggacagcgta gacgcggaag gtccggcggg ggacagcgta    720
 gacgcggagg gccgggtggg ggacagcgta gaggcggggg acccggcggg ggacggcgta    780
 gaagcggggg tcccggcggg ggacagcgta gaagccgaag gcccggcggg ggacagcatg    840
 gacgccgagg gtccggcagg aagggcgcgc cgggtctcgg gtgagccgca gcaatcgggg    900
 gacggcagcc tctcgcccca ggccgaggca attgaggtcg cagccgggga gagtgcgggg    960
 cgcagccccg gtgagctcgc ctgggacgca gcggaggagg cggaggtccc gggggtaaag   1020
 gggtccgaag aagcggcccc cggggacgca agggcagacg ctggcgagga cagggtaggg   1080
 gatgggccac agcaggagcc gggggaggac gaagagagac gagagcggag cccggagggg   1140
 ccaagggagg aggaagcagc ggggggcgaa gaggaatccc ccgacagcag cccacatggg   1200
 gaggcctcca ggggcgccgc ggagcctgag gcccagctca gcaaccacct ggccgaggag   1260
 ggccccgccg agggtagcgg cgaggtcgcg cgcgtgaacg gccgccggga ggacggagag   1320
 gcgtccgagc cccgggccct ggggcaggag cacgacatca ccctcttcgt caaggctggt   1380
 tatgatggtg agagtatcgg aaattgcccg ttttctcagc gtctctttat gattctctgg   1440
 ctgaaaggcg ttatatttaa tgtgaccaca gtggacctga aaaggaaacc cgcagacctg   1500
 cagaacctgg ctcccggaac aaaccctcct ttcatgactt ttgatggtga agtcaagacg   1560
 gatgtgaata agatcgagga gttcttagag gagaaattag ctcccccgag gtatcccaag   1620
 ctggggaccc aacatcccga atctaattcc gcaggaaatg acgtgtttgc caaattctca   1680
 gcgtttataa aaaacacgaa gaaggatgca aatgagattc atgaaaagaa cctgctgaag   1740
 gccctgagga agctggataa ttacttaaat agcccctctg ccctgatgaa atagatgccc   1800
 tacagcaccg aggatgtcac tgtttcttgg aaggaaagtt ctggatggag accaccctgc   1860
 ccttgctgcc tggaacgctt tacccaagcc ccatattatt aagaatgtgg ccaagaagta   1920
 cagagatttt gaatttcctt ctgaaattga ctggcatctg ggagatactt gaataatgct   1980
 tatgcttaga gatgagttca caaatacgtg tccagctgat caagagattg aacacgcata   2040
 ttcagatgtt gcaaaaagaa tgaaatga                                      2068



      <210> 1230
      <211> 1565
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1565)
      <223> n = a,t,c or g


      <400> 1230
 ttttgcctta ttattccacc cctttacttt gcctttgtgg acacaactcc cgtgcaggcc     60
 gcgctccacg gggctcccgg cggcccaggg gagaagcttc gacaacagga cagtttttag    120
 tcacgtggcc tgaccgtttg ccatttaagg attacagcaa atgattctat ttgtaatttc    180
 tacccttccc attgcctccc ccccaaaaaa aactgtacat gagtttacaa acatattaac    240
 atataaataa tgagaaccgt cctggtggga gcctcctccg ttgtctctgc tggagatgaa    300
 cactgagggg cgctgtaacc acacagactg cctgtgacat cgggagtctc acggcagctg    360
 tcctgggccc gcagctggct tttttggcac ctccaggttc aaccaccagt ctgtctctgc    420
 tgtgcccagg gtagagcccg ggggctgtga gtatgtgtgg ctcccctgcc cgtcatcgct    480
 ctggctcaag ctcatgctgg aagggacgct tcctctcccg acagtgcttc ttgtgggcag    540
 gccagtcctt ctgctggcac tgggagccgc agtaccgggc cacctggcag cgcccacaga    600
 tgttgaactc ccggagctgc ttctcaatca ctgtgcaggg agggtagtgg cactcatagt    660
 aggtgcaaga gttctcctcc tcttccacta catccccgtt ggcattataa taccgggtca    720
 catttaggac aggaaactgt tcttctatag ggtctgtagg cagctgctga attgcaagcc    780
 aatacaagct ttgctccctc tgcttgctgg aggtctcttc agccttgggc cgccagcccc    840
 acggcaccag ttgcaggttg tccaggcgat tgtccacggt cacagcgttg aggtgcacca    900
 cctggaagcc cggggccacg cccccccggt gccgctccct agaaacagac agcaaaccct    960
 gcatctaacc cggcatcgct gcctcccacc ctcacagaca tttctggtca ggtaccaaag   1020
 tccttccagg aagaaatgtc agccatgtga tctgatcggg cccctggtcc tttggatgag   1080
 ggtacctcag gcggaaggtg ctgagagaaa cccaagcacc tgatctgtgg cccaatcagg   1140
 acagggacac agggaggacc cggcccctgg tcttcagagc acagacagcc aaagctggaa   1200
 cgcaaaacca cctaagcaga tggcctcgag acagctcccc atctgagtgg tccctaccat   1260
 gcgcaccggg gggctcggca aaacccagca aggggagcaa cctccgtccc tccagaggct   1320
 gccagtcctg ggcaagctcc cagcagaaag tccacttggt gtttgaagtg caacatacaa   1380
 atcattcgtt cctttgggtt agtggtgaag gacacaaaaa taactgcgag attcagggaa   1440
 ggcaaggcag ggcttcagcg gggcagaagg ctccagacgc cctgtgccat cggagctcac   1500
 ccaggagccc agcgnacgcg tgggtcgncc cggntntttc ggtagactat cgggcgtcag   1560
 acacc                                                               1565



      <210> 1231
      <211> 1251
      <212> DNA
      <213> Homo sapiens


      <400> 1231
 ctttgcaata tgaaatataa tttttcaagt caaaaaagaa taaaatactt caatctgtat     60
 taatgcaatt tctctttaaa acttttaaac gtttttaata tataagagat atgttacagt    120
 ttctttaact ttaataaagc tgcagtatcc tggtttcaca ggaactcctg gcccttccac    180
 gaacattcaa aaaggatcca ctgtgttcta taataagtat cataggaacc cacccacaaa    240
 ggggaacaca ctaaacagtc cacacatccc atagcactac tatcatcttc atcataatta    300
 ttactgttca ttttttccta ctttaagaaa atggaaaact tgtggggttt tcttcttttg    360
 gaagcttcct attgaagtaa agtgtaaaaa ctatcattac tagaatgtcg ccgttcctat    420
 tatttataga gcatgcattt caggtgttca ggtttcccag gctacagtac tttttatgca    480
 gatatcctgg caaattcctt tacttaaaaa ttaaatttta aaaatgagcg gatactacag    540
 ctttccaagc tcctctcgga tctcagagtg ttggtggggc cgggaaggag aagggagagg    600
 gggggcaccc agggaggcag gcgagcgctg gggaaagagg atggggaggg gttccccctt    660
 cccccagcac ggtgcgcact agcagcgccc gctgccttta agaaaagatg cggatggcct    720
 gagtgaccgc ggtgtggcag accgggcact cgggctcgct cttctcacag atgcgattgg    780
 cgcactccat gcagaagagg ttgtggccac agggcaccag cgcggcaatc acttcgctct    840
 cgaagcacac ggagcagtcg cggctgcctt tacgccgaag cccggagaag gaggatgaag    900
 agctggagga ggagctggac gaagaggagg agcacgacgt gtccgacggc tgcaagccag    960
 gcagctgtgc ccccagcccg ttggcataag cggcgtaggc caggcctcct ccacccgggt   1020
 cgctgcgcac ccggcgagcc aggtggtgct ctcccgcccc cggggccatg tgcaagggtg   1080
 gagacaggcg cgggcagctg gtgccagggt gcagccggcg gtgcaccaat agccccaggt   1140
 tggcgttgga gggcgcactg gcgccacccc cggggaagac cacggaggag gaagaagcag   1200
 acgaagatgc agaagaagag caggaagaag ataccggagc tgcaggtccg c            1251



      <210> 1232
      <211> 1349
      <212> DNA
      <213> Homo sapiens


      <400> 1232
 cagtctcctt ctctaccaca ataattagct ggtggtggtg gcatgtgcct gtagtcccaa     60
 cactcagaag gccgaggtat gaggattgct tgaactttgg aggtcgaggc tacagtgaac    120
 caagatcgcg ccactgcact ccagcctgga tgatggagcg agaccgtctc aaagaaaaaa    180
 agttttcctg gcgattctta cacatatatg agcttttaaa agcatatatt taaataacat    240
 tttaatgaca aaatttgatg ctctcaagta tcaaaatgga aataccaaca gcaaggtttc    300
 cagggatgtc caacaccaca gagcagggag gcctggctgg gcctccactg ttgaggtcat    360
 catggtgctt ccgctttatt ctgattaact tttggttaca cacattgaaa aatgacctaa    420
 gagagttgtt ttgagtggcg ctttttctca ttgtacagct cctgctagca gtttactgca    480
 acactgattt ctctggaacc tctcagtttc cagtcatcat tagggctgtt actagcaagg    540
 acctacaagc cagcctcaaa atgtgagagg gctgccgaca gtcttcctgt ggttagctgc    600
 cacagtgccc agggaccatc ttccctctcc tcctccccca ctgccagctc ctgttccagc    660
 cgcatcagtt cctcatttga gagatcttct tcatgggact gcagcaactg gtccacagca    720
 gcctcagcaa cctcttcaaa ggccacattt ctggcaaggg tcacaatgtt tttttgaagc    780
 tgtgcaatgt tatctgcctg ggaaaaacgc tgggcctgaa cacactcagg ccaaatcttc    840
 ttccacatgc tgttcattag tgctggtttg agctcctccc atgcgatggc catgtccaca    900
 gcatccatga tgctgtagtt tctccaaaat tccctgatca tagctgtgtc ctcaccatcc    960
 gctgcttcta ggatgtgctg aaaagtcctt ctcagataat gagctttcaa ggtcgagatt   1020
 acaccttgac acgtggtccg gattgagtca gctgtactgt catgaaggta ttatactctt   1080
 ggaattcttt tttttctttt tttttttgga aacggagttt aactcctgtt gcccaggatg   1140
 gagggcaagg gcgcaatttg ggttaaccaa aacttccgcc tcccaggtta aagaaatttt   1200
 cttgttttac cctcccagaa agctggaatt acgggcctgc accaccaccc cgcgttaaat   1260
 tttttttttt aataaaaacg gggtttttcc atgttggggg tgggcttgaa ctcctggacc   1320
 taggggaacc ccccgttttg ggcttccaa                                     1349



      <210> 1233
      <211> 2242
      <212> DNA
      <213> Homo sapiens


      <400> 1233
 tttttttttt ttaaaagaaa aaatttcact ttaatccagc ctcaccccca catgtgtgtt     60
 tcacacagac cttatttttt aaacagagtt tattgtattt aatacattat aaaatttgaa    120
 aaattgtagg aaagcagcag acttgaactg gagcaattct aacaaggaat aattctggcc    180
 ccttggcaaa actgatcagt tttaaaacaa agtaaagttc acatctgtga ggtggacaaa    240
 aaagtgtgac ttctgtacaa actacattta aaatttcatg tctaacatct ttgcaatgtg    300
 ctcatgaggg tttttctgaa gtcctgcctg gtccctgcct aaagaaagac gtggaacctc    360
 catatacaaa caaacttgat tcaaggtgtt ttgtttgttt tgttttttta aaaaaaaagg    420
 aaaaagaaag acaaaggaaa aaagaaatat ggatggctgt tgttggcaat ggaaactgta    480
 aggagactgg tgtcctcacc actcatggct tgtttatttg tcagaggcct cgggaggccc    540
 aggacacttc acggccatca cagcaccaac tgcggctgtc cccttttttt tttttctttt    600
 ttgcatttcc taccttttga catatatata tatatttata tattttttac accttgagga    660
 tatcactatt ccaattgttc ccatatgaat acaggtgtgg tctctattgg atataaatgt    720
 gtcttttatt cgattttacg tccaggactt ggtttgctgt cccaactgca cataaatgtc    780
 ccttttttgt ttgagttatt ggttgtgtgt gttttccttt ttgcataaga aatatgtcca    840
 tttagtccag aggctcttgc tttatccgga tgacggaggg tacacggggc gtccgcctca    900
 gttcccgccg aaggacgtat tcgctgaact gggacgagtc tactcctccc ccacaggagc    960
 ccacgatttc aaatcctctt tgctgcaacc tctcgaggac ctggactgag ttgaggtgac   1020
 agtagccatt tagtggaaac ctgatgacgt gcgtcgagtc gtgattccag cctgcattga   1080
 cagagttaca catcacgtcg ccgatctctg gaaatacttc ttctatcaag gatttgtcac   1140
 cgcttagcgt gatcctttct ccgaggtctg gggccacacg cacgacgagg cactcacagg   1200
 gccttgaaaa tcgaccagtt tctctgtcct gcttccatct ttccatctcc aacaacatgg   1260
 gctgaagctg aaaatatttt gcctcttcat ataacaaagt gtagtccttg aaatcatcag   1320
 gaatgaggag tttggatgtt cgtagaaaat tcaagatata tctgaacatc tgtccatctc   1380
 tgtcaatgaa atagtgctgt ttgagactgt ccaaaacaat gggctctgta ccatcaaaaa   1440
 gtcttccgat tctggattca gggtatttgg tgagggtggc caggctgctg gtgtacatgt   1500
 ggccgcccac atcaatgtgg acaggcgcat tggattttgt gagttgtgct ggagtaggga   1560
 tgccttggtt gttcagtgga gatgcagggg atctagtgat cagaggtctt gacatattgg   1620
 gccgactgtc ctgggtgggg gaaacaatag caggtgaaac tattgtggga gaattggtgc   1680
 ttctgtgccc attggcttct ggaagaagag gcagggggtc gtgtttcacg gaaaccacca   1740
 ccaccgcatc cacaggctcc gaggggcgga tacaaagtct tttgggggaa gtggggccgc   1800
 agatttcccc cgacccgaac acagactcgt acagggcgcg cttgggcgca gcctcggatt   1860
 tcacgtcggg cccgacctgg ctgtctttgg ggaggatgaa aatcgcttga acctgggagg   1920
 cgaagtttgc aatgagccga gattgcgcca ctgcactcca gcctgggcaa caagagagaa   1980
 actccgtctc aaaaatgaaa ataaaataaa taaaaatgaa acagcctttt aagaatgcaa   2040
 ttattaggca acgtcttcaa aagccatgaa aatgttcata tgctttgatg cacaaattgc   2100
 ttctagaagt tcatcttagg aaatatcctg ctttacttgt agtttggtaa agtttggttt   2160
 attgcatcca ggccacttgg acaaatgaat tttgtggtat atgtcacaaa ctatgctgta   2220
 gaactgcatt ttatactgtc tt                                            2242



      <210> 1234
      <211> 397
      <212> DNA
      <213> Homo sapiens


      <400> 1234
 ggcccttccc ctcctttagc atgttcatgg gtgctgggga tgccccactg ggctctcggc     60
 ctggccaccc ccattcctca tctcaggtga aaagcaagct ccaaattggc cccccttctc    120
 ctggggaagc tcagggaccc cttctgccct ctccagctag gggtctcaag tttctaaagc    180
 tgcctccaac ctcggagaag agccccagcc caggaggccc gcagctcagt ccccagctcc    240
 cccggaactc gcgaatcccc tgtcggaaca gtggctcgga cggcagcccc tccccactgt    300
 tggcccgaag gggtctgggt ggaggagagc tgtccccaga gggggcgcaa ggcctgccca    360
 ccagcccatc accctgctac acaaccccag actgtat                             397



      <210> 1235
      <211> 1211
      <212> DNA
      <213> Homo sapiens


      <400> 1235
 gcacgagctt aaggacacca ggcaggcgcg acagccttca gcctctccct ctgcagtttt     60
 ggccggttcc tttaacttgc cttcatctgg ggctgtttgg tatttccacg tgccttgggc    120
 ccgcccactg cagcctccat cttggaagcg gccgccggcg cctagaactg tatttcagaa    180
 aaaagaaact acagttttag catgcagaaa ggaaaaggga gaacaagccg gatcagaaga    240
 cgaaaactct gcggaagttc tgaatcaaga ggagtgaatg agagccacaa gtctgaattt    300
 atagagctga ggaagtggct gaaagctagg aagtttcaag attcaaactt agcgcctgct    360
 tgttttccag gtacaggaag agggctgatg agtcaaacat ccctgcagga gggacagatg    420
 attatttcgt tgcctgagag ttgcctgctc accacgggac acagtgattc gaagctactt    480
 aggggcatac attactaagt ggaagcctcc tccatctcct ctgctggcgc tgtgcacctt    540
 tttagtttca gaaaagcatg ctgggcaccg atctcttttg gaagccttac ctggagattt    600
 tacccaaggc gtatacctgc cctgtttgtt tggagccgga agtggtgaac cttcttccca    660
 aatctttaaa agcaaaggct gaagagcaga gagcccacgt gcaggagttc tttgcttcct    720
 ccagagactt tttctcttct ctgcagcctc tgtttgcgga ggctgttgac agcatcttca    780
 gctacagtgc cctgctgtgg gcttggtgca ccgtcaacac cagagccgtg tacctgaggc    840
 ccaggcagcg ggaatgcctt tctgcagagc cggacacctg tgcaactcgc tccgtacctg    900
 gacctgctga atcatagccc acatgtccag gtaaaagcag cgtttaatga agaaactcat    960
 tcttacgaaa ttagaacgac ttcacgttgg agaaagcatg aagaggtatt catctgttac   1020
 ggccctcacg ataatcaacg gctgttcctg gaatacggat ttgtttctgt ccataatcct   1080
 catgcttgtg tttatgtctc aagaggttgg aatcaacttt gttcttaaca ttaacactat   1140
 ataatttttt tccccatttg gagatgtgta ttttcagttt taataaaaat atcaaaacct   1200
 taaaaaaaaa a                                                        1211



      <210> 1236
      <211> 792
      <212> DNA
      <213> Homo sapiens


      <400> 1236
 aatgtggcta ctgaaaccta atgggaatgc aaatagaact tttttgtctt ctcaagtgtt     60
 ccaagacctg tggacgaggg gtgaggaagc gtgaactcct ctgcaagggc tctgccgcag    120
 aaaccctccc cgagagccag tgtaccagtc tccccagacc tgagctgcag gagggctgtg    180
 tgcttggacg atgccccaag aacagccggc tacagtgggt cgcttcttcg tggagcgagt    240
 gttctgcaac ctgtggtttg ggtgtgagga agagggagat gaagtgcagc gagaagggct    300
 tccagggaaa gctgataact ttcccagagc gaagatgccg taatattaag aaaccaaatc    360
 tggacttgga agagacctgc aaccgacggg cttgcccagc ccatccagtg tacaacatgg    420
 tagctggatg gtattcattg ccgtggcagc agtgcacagt cacctgtggg ggaggggtcc    480
 agacccggtc agtccactgt gttcagcaag gccggccttc ctcaagttgt ctgctccatc    540
 agaaacctcc ggtgctacga gcctgtaata caaacttctg tccagctcct gaaaagagag    600
 aggatccatc ctgcgtagat ttcttcaact ggtgtcacct agttcctcag catggtgtct    660
 gcaaccacaa gttttacgga aaacaatgct gcaagtcatg cacaaggaag atctgatctt    720
 ggtgtcctcc ccagcacctt agggccaggg gcttaccttt caacctctag agagaccacc    780
 tgcctttgag ag                                                        792



      <210> 1237
      <211> 525
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(525)
      <223> n = a,t,c or g


      <400> 1237
 gcagnaggcg ccatcatggg agtggacatc gccattaaca aggaccgaag ggttcggcgc     60
 aaggagccca agagccagga tatctacctg aggctgttgg tcaagttata caggtttctg    120
 gccagaagaa ccaactccac attcaaccag gttgtgttga agaggttgtt tatgagtcgc    180
 accaaccggc cgcctctgtc cctttcccgg atgatccgga agatgaagct tcctggccgg    240
 gaaaacaaga cggccgtggt tgtggggacc ataactgatg atgtgcgggt tcaggaggta    300
 cccaaactga aggtatgtgc actgcgcgtg accagccggg cccgcagccg catcctcagg    360
 gcagggggca agatcctcac tttcgaccag ctggccctgg actcccctac gtccgctcca    420
 agggccggaa gttcgagcgt gccagaggcc gacgggccag ccgaggctac aaaaactaac    480
 cctggatcct actctcttat taaaaagatt tttgctgaca aaaaa                    525



      <210> 1238
      <211> 5402
      <212> DNA
      <213> Homo sapiens


      <400> 1238
 gccggttccc aggccgggtg gagaccaact ctggggtctc ttggtgggag agtggggagc     60
 ccgtcttctg ctgagtgctg ccgccccttc ccaggacagc ggaggtggaa cttcgtcgcg    120
 ctgcaacccc cggctcggga tcctggggcg tcctttggca gttgattgca ccctgcacta    180
 gagagaagtc caggaatgat atattcttgg gctgtatttc tctaccctgg agttcatcca    240
 gttcatccca gaaacactga cctgattact gtgacaaagt ctgatggata gaccctttct    300
 gttgaccttg tggcgttttt ctttcatgtg gaagttggaa gacaaggtga aaggggccaa    360
 aagttacctg ctttggtgaa taggagtgct ctacttggtt ctcagaacat gggccctcgt    420
 ttaaagctgc agctgtgatc ctcggctgtc tgttggcatt gacgggacct gatgttttac    480
 gttattggtg gaatcacagt gtctgtggtt gcattcttct tcacaattaa gttcctcttt    540
 gagcttgccg cacgtgtagt cagcttcctc cagaatgagg accgcgagcg ccgaggggac    600
 cggactattt atgactacgt gcggggaaat tacctggatc cccggtcttg caaagtctcc    660
 tgggattgga aggaccccta tgaggtgggc cacagcatgg ccttccgagt gcatttattc    720
 tataagaacg ggcagccttt ccctgcacat cggcctgtgg gactaagagt tcacatctct    780
 catgtcgagc tagcagtgga aattccagtg acccaggaag tccttcagga gcccaattcc    840
 aacgtagtaa aagtggcctt cactgtgcgc aaggctgggc gttatgaaat cacagtgaag    900
 cttggtggat taaatgtggc atatagtccc tactacaaaa tttttcaacc tggaatggtg    960
 gttccttcta agaccaaaat tgtgtgccac ttttctactc ttgtattgac ctgtgggcag   1020
 ccgcacaccc ttcaaatagt accccgagat gagtatgata atcccaccaa caattccatg   1080
 tccttgagag atgagcacaa ttacaccttg tccattcatg agctcggccc tcaagaagaa   1140
 gagagtactg gtgtctcatt tgagaaatca gtaacatcca acaggcagac tttccaggtg   1200
 ttcttgcgac tcaccctgca ttctcgaggc tgcttccatg cttgcatttc ataccaaaat   1260
 cagccaatca ataatggtga atttgacatt attgtcctaa gtgaggatga gaagaatatc   1320
 gtcgaacgca atgtgtccac ttcaggcgtg agcatttact ttgaggctta tctttataat   1380
 gctaccaact gtagcagcac tccatggcac ctgccaccca tgcacatgac ctcttcccag   1440
 cgccggccat ccactgctgt tgacgaggaa gatgaagact cgccctctga gtgccacacc   1500
 cctgagaagg tgaagaaacc gaagaaggtg tactgctatg tgtcaccaaa gcaattctca   1560
 gtgaaggagt tctacctgaa gatcatcccc tggcgccttt acaccttccg agtgtgtcca   1620
 ggaacaaaat tttcatacct tggtcctgac cctgtccata agctgctcac actggtggtg   1680
 gatgatggca ttcaacctcc tgtggagctc agctgtaagg agaggaacat tctagcagcc   1740
 acttttatcc gctccctgca taagaacata ggaggctctg agacctttca ggacaaggtg   1800
 aactttttcc agcgagagct tcggcaggta catatgaaaa gaccacattc caaagtcacc   1860
 ctgaaggtca gcagacatgc cttgttggaa tcgtctctga aagccactcg gaatttctcc   1920
 atctcagatt ggagcaagaa ctttgaggtt gttttccagg atgaagaagc tctggactgg   1980
 ggagggcctc gccgggaatg gtttgagcta atctgcaaag cactatttga taccaccaat   2040
 cagctcttca cccggttcag tgacaacaac caagcattag tgcatcccaa ccctaatcgc   2100
 cccgctcatc tgcgcctgaa aatgtatgag tttgcgggac ggctcgtggg caagtgtctc   2160
 tatgagtcct ctctaggagg agcctacaag cagttggtcc gagctcgctt cacccgctct   2220
 ttcctggccc aaatcatagg actgcgtatg cattacaagt actttgaaac agatgaccca   2280
 gaattctaca aatctaaagt ttgttttatc ctcaacaatg acatgagtga gatggagctg   2340
 gtctttgcag aagagaaata taataaatca ggtcaattgg ataaggttgt agaactcatg   2400
 acaggtggag ctcaaactcc agtcaccaat gcgaataaaa tcttctattt aaatttgctg   2460
 gcccaatatc ggctggccag tcaagtgaaa gaggaggtgg aacatttcct aaaaggcctg   2520
 aatgaattgg tccctgagaa ccttttggct atttttgatg agaatgagct tgagctgctg   2580
 atgtgtggga ctggagacat cagtgtgtct gacttcaaag cccatgcagt agttgttggt   2640
 ggctcatggc atttcagaga aaaggtcatg aggtggtttt ggactgtggt ttccagtctg   2700
 acccaggagg agttggctcg gctacttcag ttcacaacag gctcctctca gctaccacct   2760
 ggaggctttg ccgccctctg tccctcattt cagattattg ccgctccgac ccatagcacg   2820
 ctgcctactg cacacacatg ttttaaccag ctgtgcctcc ctacatatga ctcctatgaa   2880
 gaggtgcaca ggatgctgca gctggccatc agcgagggtt gcgagggctt tggcatgctc   2940
 tgaccactct cctgtcatcc agttggctcc catgctctct ggagcttctg ggcgcaagtt   3000
 acagacatca taaccactga tcctaacaca cataaccatc agccagaaga tgccgcatgc   3060
 tcccctgtgt ctggaggatt ttgtcaccta caagccttgt ctttacctca cctgctccct   3120
 gcccatatct accacaggcc actttggcat ggtatgtaag ctgagctctt cattctgtca   3180
 tgagaagagg accatgctgc tatcatttat ttggtccttt gaagatctca gtagctgagg   3240
 gagatggcac acggggctca gccctgttgg gaaactggtg tggagaccct taaatccaca   3300
 ctgtgctcca aaactccctc tgctgatact ccttggagac accctctttg gccctcacta   3360
 cttgaccaga ctggtacttg agtccttctc atgggtgggg tgattgcctc ttctcatcag   3420
 gagccaggag agagggggac agataggagg tggcccatag gagcagtccc gctgcacaat   3480
 ggtaggcata ggccatggca ctggactgcc tctaaggact gctaaaaaga atattttttt   3540
 gtggtgtcag aactggaaaa agcactttcc cttcgggcat ttctggaaat gattattaat   3600
 cacaaagaag aactctgtaa gctttttctt gaattgtagc cagtgagaaa agcagataga   3660
 ctgaagaata tgaaggatag ctgagctgta gcctccagag tggggcatgc ctaggcatat   3720
 ggctggcttg gagactactg atgcttttcc ctgagtttgt tattggcact gaagtatggc   3780
 cggcttgggc cactgacttc cccattatgt agtctgctaa aagctgggga tcctttagca   3840
 ttctactgaa gaaaattttg tagcaaaaga ttagaacagt aagaatagta tgccagcaat   3900
 ccctgattct ctctctgctt ggtgttctct ggcagcacta agacaaagga acagggacta   3960
 ggagtttacg tgcttatcac aggtccttgg cgtcaggaca ctagggatga acatggaggt   4020
 gatatgttac acagtaaaca cctgccaacc cctgtactcc cctttgctcc atcagttatc   4080
 aggaaggaga actaaggagg gaggaagctt attaggttca ctgttgaatg atgattgaag   4140
 agtacctgct gctgtatctt ggaagatgac aacatccttt ttcattactg tttgattgaa   4200
 aataatttca agattcaaaa tctcattgac ttcccaaatt tgtgttttta agaaggcttt   4260
 gctgcaagct accattccca atggggcagt caactctgag aatattacaa gccatcttta   4320
 ttgccaaaac cagcaagtac acagagtcct gaaacaaggc aggactttgg caatgccttg   4380
 gcctcctgga agcatgtctg agccctcctg ttcgcaggga tcatgaggaa caagccctcc   4440
 tgagctgcta cagttcctgc ctgacctcag tctttcgcag tcatcatttg tcctttcttg   4500
 gcacatgggt gctgacctca ctcatccttg gggtccggga tccagcatca gggtctctat   4560
 accccaggat cctccatgcc acatggtcac tgctctcctc agggaccagg acaaggtgct   4620
 gctgcttgcc caaatgtttt cccatgggat atgtaccgga aggtttatca ccaccctggg   4680
 aaacataatg ctgccccttg ggcccagaaa ggggtttcca gctgggggca cgtggactgg   4740
 ttctgctgtt tttggcagtc gcttttctga attctcccct ccggcagcct tccagagact   4800
 gatcctggag attgagttga ttgtcttggc tagacctgtc attttaagct ctagtcatag   4860
 cactttttca gagcatctta ggcaccattg caacccaacc agggaagctg catccctgtg   4920
 gtggtcctta ggcaccagtc tttgttaaac aaaacccttt ggcactattg tggttttcta   4980
 ttctctgtct gaactctatt caaaagtatc tttgctctct tgggcctttt cttttactgt   5040
 tttgtttttt ttttctaatc ctgctttcat actagccagt gtggggaaaa ggtacaatat   5100
 gtcaaagaga tgagagagtg ttatttcttg ggcaattttc tattagtgtt tcttattttg   5160
 gccagttctt ttatttatgt ccttgtgacc caggtacttg gggggccagc tacccttctg   5220
 gccttttagc gtctttgaag gagaccagac atgagtgaat acctaggaga gtgtcagcat   5280
 gtttctggaa aattggcaga gaccaagccc tgctgcagat tcgtcaggcc aggtgaaagg   5340
 gccaggcagt tgcagctgat gatgtaaata ttttgtacag tagataaata aatgtttaaa   5400
 ag                                                                  5402



      <210> 1239
      <211> 840
      <212> DNA
      <213> Homo sapiens


      <400> 1239
 atgcagcgcg gcgcgctgtc cccggtgctg atgctcagcg ctgccccgga gcctccgccg     60
 cgcccgcctc ccggcctctc cccaccgggc tcgggcccag gctcgggctc ccgccatggc    120
 tcggctcgtc ccggtcctac cccagagccg tcggggagcc tgggcgcggc gctcgacagc    180
 agcctgcgtg ccgccgtggc gttcaaggca gagggccagc gctgctatcg agagaagaag    240
 ttccgggagg ccatcggcaa gtaccaccga gcgctgctgc agctgaaggc ggcgcagggg    300
 gcccgcccta gcggcctgcc cgcccccggc ccccggggcc caccagcagc cccgggccgg    360
 cgcgcctcag cgaggagcag cggcgcctgg tggagagcac ggaggtggag tgttacgatt    420
 cctcaccggc ttggcctgct gcagtcggag ctggtaaact acgagcgcgt gcgcgagtac    480
 tgtctcaagg tactggagaa gcagcagggc aacttcaggc ccccctaccg tgccgggcat    540
 tgccttttac cccctggggg actacgcacg cgcgttgcgc ttcctgcagg aggcccccag    600
 ccgggaaccc ccagacacca atgtgctccg ctacatcmca gctgactcag ctgaagatga    660
 atcgttgcag cctccagcgg gaagacagtg gggctgggtc ccagactcgg gatgtaattg    720
 gctgaggcca atccaggggg acctctctat ccctcgccct cccacctcac catgtaactt    780
 cccccgactc atgtgtttgt tggtaaaaca cttgtcactg gtgaaaaaaa aaaaaaaaaa    840



      <210> 1240
      <211> 867
      <212> DNA
      <213> Homo sapiens


      <400> 1240
 ggcacgagga gcggatgaga tcgtggggct caccagcgtc ccccatggct tctgagtagc     60
 gtgggagtgg agtcagcacc aagccaggct ccccgcgcct gccttgccct cacctgctcc    120
 tgctctctgc cagaggcagc atggtccgca gggcaccatg gggcccgaca gagtgacagc    180
 acgagaactg tgcgagaacg acgacctggc caccagcctc gtcctggacc cctacctcgg    240
 tttccgcacc cataagatga acgtcaggtc tatcgctacc tccgtgcctt cctgccggaa    300
 agtggcttta ccatcctgcc ctgcacgcgc tactccatgg agaccaacgg ggccaagatc    360
 gtgtccactc gtgcttggaa aaagaatgag aagctggagc tgctggtggg ctgcattgca    420
 gagctgcggg aggcagatga ggggctgctg agggccggtg agaatgactt cagcatcatg    480
 tactcaaccc gcaagcggag tgctcagctg tggctgggcc cagccgcctt catcaaccat    540
 gactgcaaac ccaactgcaa gtttgtgcct gcagatggga acgcagcctg cgtgaaggtg    600
 ctccgggaca ttgagcctgg ggacgaggtg acatgcttct acggcgaggg cttcttcggc    660
 gagaagaatg agcactgtga atgccacacc tgtgagagga aaggtgaagg agctttccga    720
 accaggccta gggagcccgc gttgccacca cggcccctgg acaagtacca gctgcgtgag    780
 accaagcggc ggctgcagca aggcctggga cagtggcagc cgacagggcc tgctgggccc    840
 tcgggcctgc gtgcacccat ccccgct                                        867



      <210> 1241
      <211> 620
      <212> DNA
      <213> Homo sapiens


      <400> 1241
 tttcgtccgg gacagctcgc ggcccccgag agctctagcc gtcgaggagc tgcctgggga     60
 cgatgaggaa atggaggcac agagaggtga acttgcccga agtcactcag caggatgcag    120
 tgtgtccagc tccaataccg agcccaggtc tgagtgccca gacaggactc cagaagattt    180
 ggggaactat ccactgccaa gtttgccctg gggccccagc ctggcccggg tcaccctggc    240
 atgaggagat gggcctgttg ctcctggtcc cgttgctcct gctgcccggc tcctacggac    300
 tgcccttcta caacggcttc tactactcca acagcgccaa cgaccagaac ctaggcaacg    360
 gtcatggcaa agacctcctt aatggagtga agctggtggt ggagacaccc gaggagaccc    420
 tgttcaccta ccaaggggcc agtgtgatcc tgccctgccg ctaccgctac gagccggccc    480
 tggtctcccc gcggcgtgtg cgtgtcaaat ggtggaagct gtcggagaac ggggccccag    540
 agaaggacgt gctggtggcc atcgggctga ggcaccgctc ctttggggac taccaaggcc    600
 gcgtgcacct gcggcaggac                                                620



      <210> 1242
      <211> 1983
      <212> DNA
      <213> Homo sapiens


      <400> 1242
 atgggagatg gcaccagtga cttcgaccct atcggagaca ttgggattcg tcaatctaat     60
 tactcatgtg gagggtgccc aaggatacct tatgtttgga gagtcactgg aagggctcac    120
 gggacccaga ctatagttgt attcatggct aaggtttatt acggcaatgt aatgaggagg    180
 gagaaagact caggtggagc ctggggaaat ccatgggcag gcatcctact gccccctccc    240
 tccacgagga attgcacagt gcactcttcc ttcagcaatg aaaatatatt tccccagcat    300
 acaagttcct gtgtagttgt acataatcaa tatattggag cagatttccc ctggagtaat    360
 ttctcatttg tggtggaata caattatgtg gaagactctt gttggactaa acactgcaaa    420
 gagttgaata ttccttacat ggcctttaaa gtgattcttc cagacacagt tttagaaaga    480
 agcaccttgc tggatagatt tggaggtttt cttttggaaa ttcagattcc atatgtgttt    540
 tttgcatctg aaggacttct taatactcca gacatacttc agctgctaga atccaaggac    600
 atggatgaag ctggaaacca tcattctgag caaactgtca caaggacaga aaaccaaaca    660
 ctgcatgttc tcactcatag gtgggaattg aacaatgaga acacttggac acaggatggg    720
 gaacatcaca caccggggcc tgtcgtgggg tggcgggagc ttataattgc cccaggagta    780
 gaagcaactg ccttgataat tcgacaaatt gctgaccaca gtttaatgac ctcaaagaga    840
 gatcctcatg aatggttgga taaatcctgg cttaaagttt caccatctga ggaaaatagg    900
 aatcagatta gtaccttgtc ttctcaaagt tcagcttctg atttagactc tgtcattcaa    960
 gaacataatg aatattatca gtatttagga ttaggagaga cagtgcagga agacaaaacc   1020
 accattttga atgacaactc ttccattatg gaactaaaag aaatctcaag ttttttacca   1080
 cctgtgactt catacaatca gaccagctac tggaaagact ccagctgtaa atctaatata   1140
 gggcagaata ctccttttct aattaatata gaatcaagga gaccggctta taactccttt   1200
 ctaaaccaca gtgattcaga gtcagatgtc ttttctttgg gtctaacaca aatgaactgt   1260
 gaaactataa aatcaccaac tgacactcag aagagagtgt cagttgtccc ccgttttata   1320
 aattctcaga aaaggagaac acatgaagca aaaggtttca taaataaaga tgtatcggac   1380
 cctatctttt cactagaggg cactcaatct cctcttcatt ggaactttaa gaaaaatata   1440
 tgggaacaag agaatcaccc gttcaactta caatatggtg cacagcagac tgcatgtaac   1500
 aaattgtact ctcagaaagg taatttattc actgatcagc aaaaatgtct atcagatgag   1560
 tctgaaggcc tcacatgtga aagttcaaaa gatgagactt tctggagaga attaccatct   1620
 gtccccagtt tggatttatt tcgtgcttct gattctaatg caaatcaaaa agaattcaac   1680
 agcctttatt tctaccaaag agctggaaaa agtttaggac agaaaaggca ccatgaatct   1740
 tcatttaact caggagacaa ggaatcatta acagaagaga aaacagaggc acaagagaag   1800
 atgaccacag aagacagagg cagaggctgg ggttatgcta ccacaaaccg gagaatgcca   1860
 aggattgctg gcaaccacca ggagcctggg gagaggcgtg gaacccctcc tccctcagag   1920
 gccccagaag gatccaaccc tgctaatacc ttgattttag acttcccacc cccagaactg   1980
 tga                                                                 1983



      <210> 1243
      <211> 1012
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1012)
      <223> n = a,t,c or g


      <400> 1243
 tttggtcccg tgccgggtgc gcggcctggg agtcagcggc ccgaggcggg aagcgccggg     60
 cgagcccact gtgcggccgt cgtgggggaa gcgaaggttc ctgattccac ctacctccta    120
 agtgaaggct tccgtccctg gagaggaggc ggcgccctat atcggccttc gtcctccgcg    180
 ggtgtgctag cgttgggacg gtcctttgtt gccgcgaggg gtaggagtgg gcgtggcgga    240
 gccagctccg ttcggaacac tcccgggccg acccgactcg ctcatcctgc aggagctgcg    300
 gcgccaagat gagtggagag gagaacccag ccagcaagcc cacgccggtg caggacgtac    360
 agggcgacgg gcgctggatg tccctgcacc atcggttcgt ggctgacagc aaaagataaa    420
 ggngggggna aaaaaaaaaa cccccccccc cccgaagtcg tcttcatcgg ggactccttg    480
 gtccagctca tgcaccagtg cgagatctgg cgcgagctct tctctcctct gcatgcactt    540
 taactttggc attggtggtg acggcacaca gcatgtactg tggcggctgg agaatgggga    600
 gctggaacac atccggcccc aagattgtgg tggtctgggt gggcaaccca acaaccacgg    660
 acacacagca gagcagggcc tgcttccgcg aggccaacat cccaacccac ttcgggagaa    720
 gaaccgacag gtgaacgagc ttggtacggg cggcacttgg cttggccacc ctcgggccca    780
 cttcctagat gccgaccctg gctttgtgca ctcagatggc accatcagcc atcatgacat    840
 gtatgattac ctgcatctga gccgcctggg ctacacacct gtttgccggg ctctgcactc    900
 cctgcttctg cgtctgctgg cccaagacca gggccaaggt gctcccctgc tggagcccgc    960
 accctaagca tcctgctgcc ttcccacaac attaaactct ccttcctcag tg           1012



      <210> 1244
      <211> 932
      <212> DNA
      <213> Homo sapiens


      <400> 1244
 ggcggaattc ggacatgatc ctctccgcct ctcgagataa gaccatcatc atgtggaaac     60
 tgaccaggga tgagaccaac tatggaattc cacagcgtgc tctgcggggt cactcccact    120
 ttgttagtga tgtggttatc tcctcagatg gccagtttgc cctctcaggc tcctgggatg    180
 gaaccctgcg cctctgggat ctcacaacgg gcaccaccac gaggcgattt gtgggccata    240
 ccaaggatgt gctgagtgtg gccttctcct ctgacaaccg gcagattgtc tctggatctc    300
 gagataaaac catcaagcta tggaataccc tgggtgtgtg caaatacact gtccaggatg    360
 agagccactc agagtgggtg tcttgtgtcc gcttctcgcc caacagcagc aaccctatca    420
 tcgtctcctg tggctgggac aagctggtca aggtatggaa cctggctaac tgcaagctga    480
 agaccaacca cattggccac acaggctatc tgaacacggt gactgtctct ccagatggat    540
 ccctctgtgc ttctggaggc aaggatggcc aggccatgtt atgggatctc aacgaaggca    600
 aacaccttta cacgctagat ggtggggaca tcatcaacgc cctgtgcttc agccctaacc    660
 gctactggct gtgtgctgcc acaggcccca gcatcaagat ctgggattta gagggaaaga    720
 tcattgtaga tgaactgaag caagaagtta tcagtaccag cagcaaggca gaaccacccc    780
 agtgcacctc cctggcctgg tctgctgatg gccagactct gtttgctggc tacacggaca    840
 acctggtgcg agtgtggcag gtgaccattg gcacacgcta gaagtttatg gcagagcttt    900
 acaaataaaa aaaaaaactg gctaaaaaaa aa                                  932



      <210> 1245
      <211> 932
      <212> DNA
      <213> Homo sapiens


      <400> 1245
 ggcggaattc ggacatgatc ctctccgcct ctcgagataa gaccatcatc atgtggaaac     60
 tgaccaggga tgagaccaac tatggaattc cacagcgtgc tctgcggggt cactcccact    120
 ttgttagtga tgtggttatc tcctcagatg gccagtttgc cctctcaggc tcctgggatg    180
 gaaccctgcg cctctgggat ctcacaacgg gcaccaccac gaggcgattt gtgggccata    240
 ccaaggatgt gctgagtgtg gccttctcct ctgacaaccg gcagattgtc tctggatctc    300
 gagataaaac catcaagcta tggaataccc tgggtgtgtg caaatacact gtccaggatg    360
 agagccactc agagtgggtg tcttgtgtcc gcttctcgcc caacagcagc aaccctatca    420
 tcgtctcctg tggctgggac aagctggtca aggtatggaa cctggctaac tgcaagctga    480
 agaccaacca cattggccac acaggctatc tgaacacggt gactgtctct ccagatggat    540
 ccctctgtgc ttctggaggc aaggatggcc aggccatgtt atgggatctc aacgaaggca    600
 aacaccttta cacgctagat ggtggggaca tcatcaacgc cctgtgcttc agccctaacc    660
 gctactggct gtgtgctgcc acaggcccca gcatcaagat ctgggattta gagggaaaga    720
 tcattgtaga tgaactgaag caagaagtta tcagtaccag cagcaaggca gaaccacccc    780
 agtgcacctc cctggcctgg tctgctgatg gccagactct gtttgctggc tacacggaca    840
 acctggtgcg agtgtggcag gtgaccattg gcacacgcta gaagtttatg gcagagcttt    900
 acaaataaaa aaaaaaactg gctaaaaaaa aa                                  932



      <210> 1246
      <211> 2535
      <212> DNA
      <213> Homo sapiens


      <400> 1246
 aagaagacaa aaaaggaagc tggaaataag aaatccacac cagttagcat tctttttggt     60
 tatccactct ctgagcgaaa acagatggca cttcttatgc agatgacagc aagagacaac    120
 agtccagatt ccacaccaaa tcatccatca caaacaacgc ctgcccaaaa gaaaactccc    180
 agttcttcat ctcgacagaa agataaagtt aataaaagaa atgaacgtgg tgaaactcct    240
 ttacacatgg ctgctattcg aggagatgtg aaacaagtta aagaattaat aagtttaggg    300
 gcaaatgtga atgtgaaaga ttttgcaggt tggacaccac tgcatgaagc ttgcaatgtt    360
 ggatattacg atgttgctaa gatacttata gcagctggag cagatgttaa cacacaagga    420
 ttagatgatg acactccact ccatgattct gctagtagtg ggcacagaga tatagtaaag    480
 ctgttacttc gtcacggtgg aaatccattt caagctaata aacatgggga gcgtccagtg    540
 gatgtagcag aaacagagga gttggagttg ctactaaaaa gagaggtgcc tttatctgat    600
 gatgatgaaa gttacacaga ttccgaagag gctcaatctg taaatccttc tagtgttgat    660
 gaaaatattg actctgaaac agagaaagac tctctcatct gtgaaagtaa acagatactt    720
 cccagtaaaa cacctcttcc atctgccctt gatgagtatg agttcaaaga tgatgatgat    780
 gaagaaatta ataagatgat tgatgatagg catattctta ggaaagaaca acgaaaagaa    840
 aatgaacctg aagcagaaaa aactcattta tttgcaaaac aggagaaagc cttctatcct    900
 aaatcattta aaagtaaaaa acaaaagcca tctagggtct tatattcaag tactgaaagt    960
 tctgatgaag aagctcttca gaataaaaag atttctactt catgttccgt catccctgaa   1020
 acatcaaatt ctgatatgca aaccaaaaag gaatatgtag tttcaggtga acacaaacag   1080
 aaaggcaaag ttaaaagaaa attgaaaaat cagaataaaa ataaagagaa ccaagagcta   1140
 aagcaagaaa aggaaggaaa agaaaataca agaataacaa acttgacagt aaatactgga   1200
 ctagattgtt cagaaaagac cagagaggag gggaacttta ggaaatcttt tagcccaaaa   1260
 gatgatactt cattacattt atttcatatt tccactggta aatctcccaa acattcttgt   1320
 ggattaagtg aaaaacagtc aacaccacta aaacaagaac atactaaaac atgtttatca   1380
 ccaggaagtt ctgaaatgtc attacagcct gatcttgttc ggtatgataa tacagaatct   1440
 gaattcttgc cagaaagttc aagtgtaaaa tcttgtaagc ataaggaaaa aagcaaacat   1500
 cagaaagatt tccacttaga atttggtgaa aaatcaaatg ccaaaataaa ggatgaagat   1560
 catagtccaa catttgaaaa ttcagattgc acactgaaaa aaatggataa agaaggtaaa   1620
 acattaaaaa aacataaatt gaagcataaa gagagggaaa aagaaaagca taaaaaagaa   1680
 attgaaggtg aaaaggaaaa atacaaaact aaggatagtg ccaaagaact gcagaggagt   1740
 gtggaatttg atagagaatt ttggaaagag aattttttta aaagtgatga aactgaagat   1800
 ctctttttaa atatggaaca tgaatcctta acattagaaa aaaaatcaaa attggaaaaa   1860
 aacatcaaag atgataaatc aaccaaggaa aagcatgtgt caaaagagag gaactttaaa   1920
 gaggaacgag acaagattaa aaaggaaagc gagaaatctt ttagggagga aaaaataaaa   1980
 gatctaaaag aagagagaga aaacataccc acagataaag actcagaatt tacttctttg   2040
 ggtatgagtg ccattgagga atctataggg cttcatttag tggaaaagga aatagacatt   2100
 gaaaaacaag aaaagcatat aaaggaaagt aaagaaaaac ctgagaagcg atctcaaatt   2160
 aaagaaaagg acattgagaa gatggaaaga aaaacctttg aaaaagaaaa gaagataaaa   2220
 catgagcata agtcagaaaa agacaaatta gatcttagtg aatgtgttga taaaaaaaaa   2280
 aaaaaggaca agctatattc gcatcacaca gaaaaatgcc ataaagaagg tgagaagagc   2340
 aaaaatactg ctgctattaa aaaaactgac gacagaaggg aaaagtagag aaaagatgga   2400
 taggaaacat gacaaagaaa agcctgaaaa agagaggcat ctagcagaaa gcaaagaaaa   2460
 gcacttgatg gagaaaaaaa aataaacaat cagataatag tgaatacagt aaatcagaaa   2520
 aaggcaaaaa aaaaa                                                    2535



      <210> 1247
      <211> 737
      <212> DNA
      <213> Homo sapiens


      <400> 1247
 cgttttctcg gggagatgcg ccgcccggtc tccctgccag cggagtgctg ggccgaggac     60
 agggcggcag gggtgacagt ggggtccagg agagtctcaa aatcctaagc tttcagtatt    120
 tgttattgtg aaagaagtta attcacctga aacagaggag gggcaacctg agttatcaga    180
 aagtgacttc ctggccttcc cttctttact gatcaggtca atgtctggtc tgggtccagt    240
 gttccttccc aaactgtggg aaatggaggc ggctgtgtgg gaacattgac ccctcagttc    300
 tcccagataa ttggtcctgt gatcagaaca cagcagatgt gcagtataat cgctgtgata    360
 ttcctgagga gacctggaca gggcttgaga gtgatgtggc ctatgcctcc tacatcccag    420
 gatccatcat ctgggccaag caatacggtt acccctggtg gccaggcatg atagaatctg    480
 atcctgactt aggggaatat tttcttttta cttcccatct tgattccctg ccgtctaagt    540
 accatgtgac gttttttgga gaaacagttt ctcgtgcatg gatcccagtc aacatgctaa    600
 agaacttcca ggagctgtcc ctggagctat cagtcatgaa aaagcgcaga aatgactgca    660
 gccagaaact gggggtggcc ctgatgatgg ctcaagaggc agaacagatc agcattcagg    720
 aacgggttaa cttgttt                                                   737



      <210> 1248
      <211> 592
      <212> DNA
      <213> Homo sapiens


      <400> 1248
 atgacccagg tttctttcac ggacgacacg accgccagag tcaccacaac tttaacactc     60
 tcgttctcgc gcccctgtga gctccctccg gggcaaccga gaatgtcgtg ggaatggaaa    120
 gactgtctgc aaatgtggag ccccgaactg cagtggcttc ttgggtgtaa ggccaaagaa    180
 tcaacccatt gccacggaag aaaagtcaaa gaaattcaag aagaagcaac agggaaagcg    240
 caggacccag ggtgaaatca caaaggagcg agaagatgag tgttttagtt gtggggatgc    300
 tggccagctc gtctcctgca agaaaccagg ctgcccaaaa gtttaccacg cagactgtct    360
 caatctgacc aagcgaccca ctttgggtct cctgagagct gtactgtcgc tcagtaaagc    420
 tcctcttcac cttgttcatg ctccagttgt ccgtatacct cattgttcct gaatgcagga    480
 caagaacctg ggacctgtca aatggtgggg ctgaaagagc ggtaacacaa acagggctga    540
 aatatgtctc ccttgctcgc cgtgttgcag gcaacaagaa ggagagaaga gg            592



      <210> 1249
      <211> 1990
      <212> DNA
      <213> Homo sapiens


      <400> 1249
 tttttttttt ttccaggtgt ggatttttat tttcacaaaa agacaacaat gtcttcccca     60
 catacaagta tttacaaaac ccaactgatt cacccatcta gaacctgggt ttttttccac    120
 ttctcaacat agttgggaac atggaaacat taatacccac acaattccca gagatggaat    180
 ttatccatca aacaaacagt gcagattacc taaaagtgca cttacctgca caactcggtc    240
 taagaacctt gtgaaacaaa cctcatggcc aaggtttcat gaatctattt ggtttcatac    300
 catgcaaacc tgaacaagtg tgctgctaca ctaaactgaa aatcggttct cattttacaa    360
 ttaaaaaggt tctcaacact ttagcaacta tacagaatat gaaggtttat ttcaaaaaag    420
 attacatttt tttaaaccag gatacacaga tgcacttaat gtaacagtac cttctgcaaa    480
 aataggttac ataatactca gaaatgcaat gaacaatctt attctctaaa aattagacag    540
 ctaagacttc ttaagtgtag acagccttca aaatggaggc tgaaaatgct tggtaaaaag    600
 aagtaactct agagccagac accacagagc taaggctgca aattaaacca ctaccacaca    660
 gctgcaaact actctttata ttcacacagc gttaaacaaa acgacttcaa ttccatcttt    720
 tcaaatgtgc ctcggtgctg caagaaaaaa agttgaatga tacacaaaac tattaaaagt    780
 tacaacagaa ctatttaaac atcttctcca aaattgagaa aagcaatcat gttaaatttt    840
 taaaaagaaa agtctgacag aactctcaag caagtcagag gtcctcttca taagtagtca    900
 agtaaagttt acaggagatt tcaataaatt atcttaaaac cttggcagag agctcatttt    960
 cagaatcgtc gcggaggtcc acccttaaat ggcttaaatc cggagccact tcctcttggc   1020
 atggaattgc cactgatttg tacaattcta ttaattgggg atgcgttact tgaatgttgg   1080
 gttatcatgc ctgctcctgc ccggccgtca cccattcgcc tcgtatcatg atagctaggc   1140
 ccttgagagg gtggaccatg ccactctttc cttggtccgc ttgtgtcccg tccatggcgt   1200
 tcaaccacat gtcgctcctc aggatagtgc tgtgatccac ctcctcggtc tgtgatgact   1260
 cctctgtctc cctctctgct cccgtacccc gaagcgctgc tacgattccc agggggagcg   1320
 cctctcacac tgtgccctga tacttctctc ccagatcgtt ctggcctttc aactcttgtt   1380
 tcccgtttgt cagtggacat gcttccttca cttttccagc tggtgggtct ggaaggattg   1440
 ggccctgcct ctcgaggatg tctaggatga gtgatatcag gcctgtcatg aataatcacc   1500
 gttctccttt cgtctcgctc ccctcgtact tctcgcctgt ctgattctct aagttcattt   1560
 cttggtggtg gaggctcatt tcttctggag tcactgaaat ttttgggata tctttcgaag   1620
 cttggatctt cccttcgtgc agtaggtcgt gcttttttcc cctcactttg accaacaaag   1680
 cgatcccgcc tttcaaaaga tgaagactgt actgctgaac tctcaggaaa cctgcccctc   1740
 tctcggtgat caaagtcatt aaatctgttc tgttggcgag agtagtcgga tccatggcca   1800
 aatcgtgcat ctgtatctag agacaacttt ttattctcgc tccagtaagg atcatctcgc   1860
 ctatgatcta catcacgtgg gcgtttcaag gaattccttt tttcttgttc ataacgaagc   1920
 tgctgttgtt gccttctgag ttcctctctt tctcgagcaa tccgttcagc ttccttacga   1980
 cgttcctgtt                                                          1990



      <210> 1250
      <211> 447
      <212> DNA
      <213> Homo sapiens


      <400> 1250
 gtagcctgcg acggaactcc cgggtctacc gacgcgtccg gggatgcttt gtatctggag     60
 aggcgctcct gattggcctg aggggccccc cagctccggg gagttgtcct ccattcagcc    120
 cactcaaggg ttgcacaact gcttccagcc ggacggagct cggccggctg cgccggggcc    180
 tgtcccaggt cagctcggtg cccttccttg gagctgccgg ccaccagcag agcctaccct    240
 cttcatggaa agcctcgtgc agtggccccc tggtgatggc atccgacagt gatgtgaaga    300
 tgctgctgaa cttcgtgaac ctggcgtcca gcgacatcaa ggcagccctg gataagtccg    360
 caccctgccg ccgctccgtg gaccatcgca agtacctgca gaagcagctc aagcgcttct    420
 cccagaagta ttcccggctc ccgcggg                                        447



      <210> 1251
      <211> 2061
      <212> DNA
      <213> Homo sapiens


      <400> 1251
 gagaaagcag ggactcttcg gcctaggcag ccgggaccca gccagccctg cgcctcgcgc     60
 cgtcgcgcat gcgtcctggg tatgtccacg cgcaataagg aggggcgaaa ggacattttt    120
 tttttttctt gctcccgcct ctgttcttcc cccacctgcc acgtacagag cccaagttct    180
 cgctaggctt gttgggtcag cgcgattggc cggggcccgc gcgagcctgc gagcgaggtg    240
 cggcggtcgc gaagggcaac cgagggggcc gtgaccaccg cctccccgcg acgccccagt    300
 ccagtggcct cgcgtccgcc cattcagcgg agacctgcgg agaggcggcg gccgcggcct    360
 ccgcaagccg tctttctcta gagttgtata tatagaacat cctggagtcc accatgaacg    420
 gacagttgga tctaagtggg aagctaatca tcaaagctca acttggggag gatattcggc    480
 gaattcctat tcataatgaa gatattactt atgatgaatt agtgctaatg atgcaacgag    540
 ttttcagagg aaaacttctg agtaatgatg aagtaacaat aaagtataaa gatgaagatg    600
 gagatcttat aacaattttt gatagttctg acctttcctt tgcaattcag tgcagtagga    660
 tactgaaact gacattattt gttaatggcc agccaagacc ccttgaatca agtcaggtga    720
 aatatctccg tcgagaactg atagaacttc gaaataaagt gaatcgttta ttggatagct    780
 tggaaccacc tggagaacca ggaccttcca ccaatattcc tgaaaatgat actgtggatg    840
 gtagggaaga aaagtctgct tctgattctt ctggaaaaca gtctactcag gttatggcag    900
 caagtatgtc tgcttttgat cctttaaaaa accaagatga aatcaataaa aatgttatgt    960
 cagcgtttgg cttaacagat gatcaggttt cagggccacc cagtgctcct gcagaagatc   1020
 gttcaggaac acccgacagc attgcttcct cctcctcagc agctcaccca ccaggcgttc   1080
 agccacagca gccaccatat acaggagctc agactcaagc aggtcatcag attgaaggtc   1140
 agatgtacca acagtaccag caacaggccg gctatggtgc acagcagccg caggctccac   1200
 ctcagcagcc tcaacagtat ggtattcagt attcagcaag ctatagtcag cagactggac   1260
 ctcaacaacc tcagcagttc cagggatatg gccagcaacc aacttcccag gcaccagctc   1320
 ctgccttttc tggtcagcct caacaactgc ctgctcagcc gccacagcag taccaggcga   1380
 gcaattatcc tgcacaaact tacactgccc aaacttctca gcctactaat tatactgtgg   1440
 ctcctgcctc tcaacctgga atggctccaa gccaacctgg ggcctatcaa ccaagaccag   1500
 gttttacttc acttcctgga agtaccatga cccctcctcc aagtgggcct aatccttatg   1560
 cgcgtaaccg tcctcccttt ggtcagggct atacccaacc tggacctggt tatcgataag   1620
 gaggctcctc tacaccaatt aatgtagctg ctagctattg gcctcccaaa agactccagt   1680
 actattttaa tttgtattga agaagttcag aaatttaaaa gcagagcatt ttttatgata   1740
 tcattgttgg tgttaattga aagtataatt tgctggaaca caaagaccaa aatgaaagtt   1800
 ttttcctccc tgcttaaaaa tgtagcagct tcttagttac tttggaacac tactcttaca   1860
 tgtataaagt gattgacttg actttctagc ttcccttgtc cggaggatat taaaatgcta   1920
 gggtgaggtt tagccatctt acttggcttt ttactattaa catgatgtac taaagtagag   1980
 ccctttgaga atacaagata ttatgtataa aatgtaacac tgatgatagg ttaataaaga   2040
 tgattgaatc caaaaaaaaa a                                             2061



      <210> 1252
      <211> 2193
      <212> DNA
      <213> Homo sapiens


      <400> 1252
 gaagatattt aaaggcgtcg gcgccacgcg catatccctg ctcggcgctg cccgcccagt     60
 tcctgttccc agactgaggc ccagccccct tcgcccgttt ccatcacgag tgccgccagc    120
 atgtctgaca aactgcccta caaagtcgcc gacatcggcc tggctgcctg gggacgcaag    180
 gccctggaca ttgctgagaa cgagatgccg ggcctgatgc gtatgcggga gcggtactcg    240
 gcctccaagc cactgaaggg cgcccgcatc gctggctgcc tgcacatgac cgtggagacg    300
 gccgtcctca ttgagaccct cgtcaccctg ggtgctgagg tgcagtggtc cagctgcaac    360
 atcttctcca cccaggacca tgcggcggct gccattgcca aggctggcat tccggtgtat    420
 gcctggaagg gcgaaacgga cgaggagtac ctgtggtgca ttgagcagac cctgtacttc    480
 aaggacgggc ccctcaacat gattctggac gacgggggcg acctcaccaa cctcatccac    540
 accaagtacc cgcagcttct gccaggcatc cgaggcatct ctgaggagac cacgactggg    600
 gtccacaacc tctacaagat gatggccaat gggatcctca aggtgcctgc catcaatgtc    660
 aatgactccg tcaccaagag caagtttgac aacctctatg gctgccggga gtccctcata    720
 gatggcatca agcgggccac agatgtgatg attgccggca aggtagcggt ggtagcaggc    780
 tatggtgatg tgggcaaggg ctgtgcccag gccctgcggg gtttcggagc ccgcgtcatc    840
 atcaccgaga ttgaccccat caacgcactg caggctgcca tggagggcta tgaggtgacc    900
 accatggatg aggcctgtca ggagggcaac atctttgtca ccaccacagg ctgtattgac    960
 atcatccttg gccggcactt tgagcagatg aaggatgatg ccattgtgtg taacattgga   1020
 cactttgacg tggagatcga tgtcaagtgg ctcaacgaga acgccgtgga gaaggtgaac   1080
 atcaagccgc aggtggaccg gtatcggttg aagaatgggc gccgcatcat cctgctggcc   1140
 gagggtcggc tggtcaacct gggttgtgcc atgggccacc ccagcttcgt gatgagtaac   1200
 tccttcacca accaggtgat ggcgcagatc gagctgtgga cccatccaga caagtacccc   1260
 gttggggttc atttcctgcc caagaagctg gatgaggcag tggctgaagc ccacctgggc   1320
 aagctgaatg tgaagttgac caagctaact gagaagcaag cccagtacct gggcatgtcc   1380
 tgtgatggcc ccttcaagcc ggatcactac cgctactgag agccaggtct gcgtttcacc   1440
 ctccagctgc tgtccttgcc caggccccac ctctcctccc taagagctaa tggcaccaac   1500
 tttgtgattg gtttgtcagt gtcccccatc gactctctgg ggctgatcac ttagtttttg   1560
 gcctctgctg cagccgtcat actgttccaa atgtggcagc gggaacagag taccctcttc   1620
 aagccccggt catgatggag gtcccagcca cagggaacca tgagctcagt ggtcttggaa   1680
 cagctcacta agtcagtcct tccttagcct ggaagtcagt agtggagtca caaagcccat   1740
 gtgttttgcc atctaggcct tcacctggtc tgtggactta tacctgtgtg cttggtttac   1800
 aggtccagtg gttcttcagc ccatgacaga tgagaagggg ctatattgaa gggcaaagag   1860
 gaactgttgt ttgaattttc ctgagagcct ggcttagtgc tgggccttct cttaaacctc   1920
 attacaatga ggttagtact tttagtccct gttttacagg ggttagaata gactgttaag   1980
 gggcaactga gaaagaacag agaagtgaca gctaggggtt gagaggggcc agaaaaacat   2040
 gaatgcaggc agatttcgtg aaatctgcca ccactttata accagatggt tcctttcaca   2100
 accctgggtc aaaaagagaa taatttggcc tataatgtta aaagaaagca ggaaggtggg   2160
 taaataaaaa tcttggtgcc tggaaaaaaa aaa                                2193



      <210> 1253
      <211> 992
      <212> DNA
      <213> Homo sapiens


      <400> 1253
 cggacgcgtg ggccgagacc cgccattgga cggctctgac ttttgctgtg ttgcatggac     60
 atattcctgt agttcagctc ctcctggatg ctggggccaa ggtggaaggc tcagtggagc    120
 atggcgagga gaactactcg gaaacacccc tccagctggc agctgctgta ggaaattttg    180
 agctggttag tttgctgttg gagcgtggtg ccgatcccct gataggaacc atgtacagga    240
 atggaatttc tacaaccccc cagggtgata tgaactcttt cagccaggct gcagcccacg    300
 gacacaggaa tgtgttccgc aaactgctcg cccagccaga gaaggagaag agtgatatcc    360
 tgtccctgga ggagattctg gccgagggga ctgacctggc ggagacagcc ccgcccccct    420
 tgtgcgccag ccgcaacagc aaggccaaac tgagggccct gagggaggcc atgtatcaca    480
 gcgctgagca tggctacgtg gatgtcacaa ttgatatcag gagcataggc gtcccgtgga    540
 ctctgcacac gtggctggag tctttgcgga tcgccttcca gcagcaccgc aggcctctca    600
 tccagtgctt gttaaaggag tttaagacca ttcaggagga ggaatacacg gaggagctcg    660
 ttacccaagg cctgcccctg atgtttgaga tcctgaaagc gagcaagaat gaagtgatca    720
 gccagcagct gtgcgtcatc ttcacacact gctacgggcc ctaccccatc cccaagctca    780
 cagaaatcaa acggaaacag acctcgcgct tggatcctca ttttcttaac aataaagaaa    840
 tgtctgatgt tacatttctg gtagaaggaa gaccatttta tgctcacaaa gtgctgttat    900
 ttacagcctc tccaagggtc aaagcactcc tctccagcaa gccgacaaat gatggcacct    960
 gcatagagat tggttatgtg aaatactcca tc                                  992



      <210> 1254
      <211> 2223
      <212> DNA
      <213> Homo sapiens


      <400> 1254
 atgacttctg tcatcagaga cacaataatg acaagatatg gtccaatttt acccacacat     60
 cagccacatc caattcaaca gggagcatgc tccagggata agagaatctg gtcctgggaa    120
 cagaaacagg aaactggcag ccagctgggg tgggaatgta aattagtaca actactgtgg    180
 aaaacggtgt ggagattcct taaagaacta aaagtagaat taccatttga tccagcaacc    240
 ccactactga gtatctaccc aaaggaaaag aagtcactat atgaaaaaga cacacgcaca    300
 tgcatgttta tagcagcaca gttcacaatt gcaaaaatat ggcatcagcc taagtgccca    360
 ccaaccaaca agtggataaa gaaaatgtgg tatacataca tcaagaaata ctactcaacc    420
 ataaaaagga atgaaataat gtattttgca gcaacttgga tggagctgga ggctattatt    480
 ctaagcgagc atccacttgt gctgattcat ccacagattt tccggccaga tgccccattg    540
 gcaaagccct ggagccttcc cttcattagt tctccgctcc agccatccga gaagtcaagg    600
 ttaaaaacaa cacactgggg tggcggcggc agcgaggaca gcggtcggca gggtgccttt    660
 gtcgcattcc ctgagagaag cggtgtctgt gaggtggtgt ccatcatgtt ctctttcaac    720
 atgttcaacc acctaattcc cagggtcttc caaaaccgct tctccacaca ctaccgctgc    780
 ttctctgtgt ccacgctagc agggcctaat gacaagtcag atgtggagaa aggagggaag    840
 ataattatgc tgccctcagc cctggaccaa ctcagccaac ttaacattac ctatcccatg    900
 ctgttcaaac tgaccagtaa gaatttggac cgcatgacgc actgtggcgt gctggagttt    960
 gtggctgatg agggcatctg ctacctccca cactggatga tgcagaactt gctcttggaa   1020
 gaaggcagcc tgcctcagag ccctgacatc ctggacatca ctaaccccaa agctgtatta   1080
 gacaacgcac ttaggaactt tgcctgtctg accaccggga atgtgactgc catcaactgt   1140
 aatgaaaaga tctatgaact cgaactgcgt gtgatggaaa ccaaacccaa caaggcagtg   1200
 tccatcactg agtgtgacac aaacgtggac tctgatgctc ccctgggcta caaagaaccc   1260
 gaaagacaag tccagcacga ggagttgaca gaaggtgaag ccgaccacag tggctatgct   1320
 ggagagctgg gcttccgtgc cttctccggc tctggcaaca gactggatgg aaagaaagaa   1380
 agcccctccc caatcaagcc tggagacatt aaaagaggaa ttcccaatca tgaatttaaa   1440
 cttgattccc tcaactcgtg tatgtcacct gccaggttcc tagaagcatc tgagattgtg   1500
 ttcggtgacc aggaggcaat tggctccaca ttcatgggga ctcatcccat tccagaactt   1560
 actcttactt ttaactggtg gagaagagta agcatccact ttcctgagag ctccaacaag   1620
 agagaagagt gtggagtgct tcatctggac atccacggga agaaggaaga catgagaatc   1680
 acccaacagt cttcccagct atacctgtgg gacatgggtg gttttacaat atttaagaac   1740
 ctgtggatga gcctcatacc cagagggaac aaacgctccc caaaaagagt tacagaaacc   1800
 atcctgagag attttaagca gaagcaaagt tcaaagatcc aagaggagag acgaagagag   1860
 tctgcaggac caaacctctc ttcattctgg tttgtgggca gaatctggaa ggcagctata   1920
 gggcaggtgg gtggttcttt tagatctgag tactgggcat tttcagaaga gaggcataga   1980
 gaaggtagaa gaaaagggat gctttttagc caaatcctcc atatgtttca gatctgcaaa   2040
 agcccaggaa aattacccta tggaggtgaa tctagctata gtacatttct tcggaaaaat   2100
 tactcaccca gacgctcagc tgtcctggag tggatgaagc tgagtgttca gctagaaagt   2160
 aatgtgtccg attcagtaca tcaacaaacc cgctttgttc tggggcaaaa gaagcaaatc   2220
 taa                                                                 2223



      <210> 1255
      <211> 1023
      <212> DNA
      <213> Homo sapiens


      <400> 1255
 ggacggtcaa gtgccaaggt ttgcatgctt caggtcgact tttaaagaat ccttgtggaa     60
 agagtcagaa aaagagcaag agagcttgat tcggaggccg tgcctctcag agtggcctcc    120
 cgatccttga atcggagccc gtgcctatca gcctggcctc ctgatccttg aatcggaggc    180
 cgtgcctctc agcgtggcct cccaatcctt gaatcggagg ccgtgcctct catcgtggcc    240
 tcccgaccta gcatggtgga gagcgccccc tgccggtaga tcctgggccg gcacactgag    300
 agcggcaggc cccgccggag gggccagcgc aggaccgggg agaatggagc tcacccagtg    360
 cctagccctg cgtttactct cagtttcctg ctggagagca atgcctcaaa ctacacagtc    420
 cggcggaggc gagtccgcca gctctggaag cctctgaggc acagacgagg aaagcgcctg    480
 aatgtggatc tggggtacca gaagttgccg gtggctcttg cccctgtctt cttctttgcc    540
 ttccaagaca ccaagctgtt cccacccaag gtcctggcac ttactctccc tgcacctcac    600
 accagcccca catcttccca aggccagctg ctccccatca cctgggtctc ctccaaaacc    660
 cgcacaatgc tgcatcctgc atccagtgcc tatatcccgc tggggtggcc accaccatgc    720
 ccaggagaaa ggctgaaggg gatgctgaag gagataagcc aaggtgaagg acgaaccaca    780
 gagaaggccc gcaaagttgt ctgctaaacc tgctcctcca aatccagagg ccaagcctaa    840
 aaatgcccct ggggtcacac tgtcacttcg tggaactgcc acaaggttct gaccctgaag    900
 ggtccacact tgctgattca aatcattaat agtcccagta ataggtttac acaccaacgt    960
 agatggaatg atgtgcatgg acatggccga aagcctctgc tcctccacat agcccaagcc   1020
 cat                                                                 1023



      <210> 1256
      <211> 1401
      <212> DNA
      <213> Homo sapiens


      <400> 1256
 atgacaaaga aaagaaggaa caatggtcgt gccaaaaagg gccgcggcca cgtgcagcct     60
 attcgctgca ctaactgtgc ccgatgcgtg cccaaggaca acgccattaa gaaattcgtc    120
 attcgaaaca tagtggaggc cgcagcagtc agggacattt ctgaagcgag cgtcttcgat    180
 gcctatgtgc ttcccaagct gtatgtgaag ctacattact gtgtgagttg tgcaattcac    240
 agcaaagtag tcaggaatcg atctcgtgaa gcccgcaagg accgaacacc cccacctcga    300
 tttagacctg cgggtgctgc cccacgtccc ccaccaaagc ccatgtcagg cgctggtcgg    360
 ggcaggagcc acctggatga ggggagagag ggtgcaggag atgaggtggg agagttaagt    420
 ctgcagcagg agattgacaa ggaccctctg ggtggtgcac tgggggcagg atccagggga    480
 acaaagacaa cagggatgca ggcaggcatt ggaggaggag agcaggtgct cgtcttttgg    540
 gatagctcct tgcccgctgt tgtagacagc tgcttccatc cagtgccctc tccagacacc    600
 agcgctgctc tcagctggtg ccttttgtca ttttcacgta caccccagca gccgagtcct    660
 ggcaatttta ggcctgagca cttgcctctt ctcttcctca gtaccgtcct accccagtct    720
 gtggcccaga cccaggcaag tggtaaatat ttaccttcac gctggagcca agatcgctgc    780
 ggggagtccc gtgaagcacc actgccctct aagaccttgg aaggggaaac accagaaggt    840
 gtgggtgctg agctccgctg cgtcagactg ccaggacctg agtggaactc agtgctgaaa    900
 cctgggttct cactgcagct ggatagcagc tctgcccgga tggccctagt cttcgtgtac    960
 ggcaccctga agcggggtca gcccaaccac agggtcctgc gggacggcgc ccacggctcc   1020
 gcagcctttc gggcgcgcgg ccgcacgctg gagccctacc cgttggtgat cgcgggggag   1080
 cacaacatcc cgtggctgct gcacctgccc ggctcggggc gcctcgtgga gggcgaggtc   1140
 tacgcggtag acgagcggat gctgcgcttt ctggatgact tcgagagttg cccggccctg   1200
 taccagcgca cggtgctgcg ggtacagctg ctggaggacc gggccccggg cgcagaggag   1260
 ccgccagcgc ccaccgcggt gcagtgcttc gtgtacagca gggccacctt cccgccggag   1320
 tgggcccagc tcccgcacca tgacagctac gactccgagg ggccgcacgg gctgcgctac   1380
 aacccccggg agaacagata a                                             1401



      <210> 1257
      <211> 401
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(401)
      <223> n = a,t,c or g


      <400> 1257
 cccacgcgtc cgtgcaaacc tccacagact tctccaaatt ctggaaaact ctctcccagt     60
 agcaatggct gtatgaatac acttcatatc agcagcacaa acactgtcgg ggaagtgatc    120
 gaggccctgc tcaaaaagtt tctcgtgact gagagccctg ccaagtttgc actttataag    180
 cgttgtcaca gggaagacca agtctacgcc tgcaagctct cagaccggga acatccactc    240
 tacctgcacg acancncata nnaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    300
 aaaaaaaaaa aaaaaaaaaa nggggggggg gggcctttaa aaaaaaccca ttttcacccc    360
 cggggggggg aaagaaaatt tttttttttg ggggccaaaa a                        401



      <210> 1258
      <211> 1581
      <212> DNA
      <213> Homo sapiens


      <400> 1258
 tttttttttt ttcacattca gttcttttat ttaattttct agtggacaat ttacatatct     60
 ccctcaccct gtcttttaag ttagtgtgac aattttccat aataaactac ttaaagagaa    120
 gctttggtca agaatggaat gaaatcgcaa aaaaacaaac aaaaaaatta ctgccttaaa    180
 aaaaccaaca ctttcaccaa ttttatattc aaacaaaacc acacggcatt ggcgtgatat    240
 gtgttttcag tgtttccttg gggctggctt cctcgccatc gtgccacggc acagctgcgg    300
 tcggccacag tttgtcatgc tggatggcgg aggctcactc agcttcacat tatccggagg    360
 ccctggatgg aagactcgag ggtcttgaaa tcccaaattg tcatggctcc atcgatgcca    420
 gtagtgcaaa atttgcgaca atcttgcttg tccacctcat aaatagagac ttgagtgatg    480
 ctattctggt gcagcgtctc caaggccgtg ttgcggtcct cagttgtggc tctcttgtcc    540
 atgttgcgga agcgttccat ggcagacatg ttgcgttgga tgctctgttt tggaatatct    600
 aacttggaga cgaaggtcag gcagccgcgg tcatcgtagt taaagagcat tgggcagcag    660
 tcatggccag cagccacgac gctgttctct gagacaaatg acacacttag gagcggcagg    720
 aactctgtct tcagagtcga gacctgcaca ctttttgagg catcagcaac agacacggtg    780
 ctgtcgtggc tgacccaggc caggcggctc ccactggcag agaagcttac cccgtggacc    840
 cagccaccag tgccactgcc accaaactct gacatcagct gcccaaaagg catcttgctg    900
 ccccagggcg tgctggctgg cttttcatcc acttctttaa tgtaggcaga aaacactctg    960
 catttgaagt cacatgatcc tgctgccagc aaaacgttgt tgggatgcca atccaagctg   1020
 aggactgtgg agcgaatcgg ctttttaatg tgcttgctca cccaccagtc attttcagac   1080
 tcaaagtaac aaacagaaat gagtcgtgct ccacttccca cagcaaattt gttctctagg   1140
 ggggaccact tcacaaaagt agctgcgcga ttaattctca ggatcaccag ggttggcttc   1200
 caaacaccat ctttctgact ccagacatag gcattgcggt ctgccccaca agtgacaatg   1260
 cggtcgctct tgggagccca gtcaatacct gtgatgtgtc cgttgtgctc cttgagttca   1320
 tgagctttca cccactggct cccgttcttc ttatagatgt gcacttcgtg attattggga   1380
 ctgagggcaa tctgagtacg atccctgttc caggcatgac aggtgattgg ctctagtaaa   1440
 aactgatgca gtgacattat tcttagtgtt ttcaaaggag agaaagctgg gatcggggga   1500
 gtccggacgg gctcggagcg gaggattcgc ggactctggg cagtcgacgc gaacaggctc   1560
 cgtcgggcgc gggcggagga c                                             1581



      <210> 1259
      <211> 406
      <212> DNA
      <213> Homo sapiens


      <400> 1259
 tgtgctgcaa ccatgtctct agtgatccct gaaaagttcc agcatatttt gcgagtactc     60
 aacaccaaca tcgatgggcg gcggaaaata gcctttgcca tcactggcat taaaggggtg    120
 ggccgaaaat atgctcatgt ggggttgagg aaagcaaaca ttgacctcac caagagggcg    180
 ggagaactca ctgaggatga ggtggaacgt gtgatcacca ttatgcagaa tccacgccag    240
 tacaagatgc cagactggtt cttgaacaga cataatgatg taaaggatgg agaatacagc    300
 caggtcctat ccaatggtct ggacaacaag ctccgtgaag acctggagcg actgaagaag    360
 attccggccc atagagggct gcgtcacttc tggggccttc gtgtcg                   406



      <210> 1260
      <211> 1036
      <212> DNA
      <213> Homo sapiens


      <400> 1260
 gctactgtag gaggaagaga gatttatgta aagggctttg tccactataa agtccgggct     60
 ctgtttccct gtgagaagcc gcctcggccc accgagatgt cccggcacca tagccgcttc    120
 gaaagagatt accgggtggg ctgggaccgc cgcgaatgga gcgtcaacgg gacgcatggg    180
 accaccagca tctgcagtgt cacctcgggg gccggtggcg gcacagccag cagcctcagc    240
 gtccggcccg gcctcctgcc gctgcccgtg gtgccctccc ggctgcccac cccggctaca    300
 gctcctgctc cctgcaccac cggcagcagc gaggccatca ccagcctcgt ggccagctct    360
 gcgtctgcgg tcaccaccaa ggctcccggc atctccaaag gggacagtca gtcccaggga    420
 ctggcgacca gcatccggtg ggggcagacg cctatcaatc agtccacacc ctgggacact    480
 gatgagccac cctccaaaca gatgagagag agtgacaatc caggcacagg gccatgggtg    540
 accacggtgg ccgccgggaa ccagcccacc ctgatcgcac actcctatgg agtggcccag    600
 cctcccacct tcagcccggc tgtgaacgtc caggccccgg tcattggggt gaccccctca    660
 ctgcctcccc acgtggggcc ccagctcccg ctgatgccag gccactactc gctccctcag    720
 ccgccctctc agccactgag cagcgtggtg gtcaacatgc ctgcccaggc cctgtatgcc    780
 agccctcagc ccctggccgt gtccacactg cccggtgtgg ggcaggtggc ccgcccagga    840
 cccaccgctg tgggcaacgg ccacatggca gggcccctgc tgcctccacc gccgccagcc    900
 cagccgtccg ccactctccc cagtggtgcc cctgccacca atgggccccc cacaaccgac    960
 tcggcccacg ggctgcagat gctgcggacc attggcgtgg ggaagtatga gttcaccgac   1020
 ccggggcacc ccagag                                                   1036



      <210> 1261
      <211> 723
      <212> DNA
      <213> Homo sapiens


      <400> 1261
 atgagctggg aggtggtgtg cgcccttctc ctgcctccag ctcctctctg gacccctgtc     60
 ctggcacctc ttcggtccct ggttcggtct gcccctttcc caccgcggcc cgtcttaggc    120
 caggatgtgc tccctgccct gcggactctg gagcagggcc cggccactcc ccggagcctg    180
 tatgacggga accgccccgc gccctctccc ctacgcgggg caggccagcc ctggggcgcc    240
 ttaaaaaccg gagctggcgc ttggcatcgc cactctgggc aggatccaac gtcgctccag    300
 ctgctcttga cgactccaca gataccccga agccatggca agcaagggct tgcaggacct    360
 gaagcaacag gtggagggga ccgcccagga agccggttta ccatggaacc atctctgcaa    420
 tgcagcccct tccacattgc cccagcccca tggagctggt gctccggtgg cgctgtgcaa    480
 ttgcctgttc ctgtgtgcct ctgctccccc gacactagga gccctggagg gcagggccag    540
 ggtgcatctg agaaagacat cgtgcactct ggcttggcat acacaatgga gcgttctgcc    600
 aggcaaatta tgcgcacagc catgaagtat aacctgggat tggacctgag aacagctgcc    660
 tatgttaatg ccattgagaa agtcttcaaa gtgtacaatg aagctggtgt gaccttcaca    720
 tag                                                                  723



      <210> 1262
      <211> 803
      <212> DNA
      <213> Homo sapiens


      <400> 1262
 acgtacgtat gagcaaccgg cctttatttc ccgggacgac gatttcttct gagaaagaac     60
 gacaggttca gagacgccgc taggattaag tttaagactt cgcgagaaca gaatttcttt    120
 tggcacctcc tctccgcgcg ttcttggggt gaggctgggt aattgttcct gcagggtggt    180
 gggtgatagt ggccagttga ctgcgactgt gtttgggtgg tgggaagcct gaagaaaagg    240
 ttgtttctta ccggtcgctg cctcagggag gtagtgcggt agaattttcc gctatgggtc    300
 attctcggtg tccgcgggga agggcgtgac aacgacgggc gtgacggcga agcaacagtg    360
 tctcgagagc gctgccgccc ggagggcgcc aggagaagtg cgtccgagac gccgcgcggt    420
 gatgctcctg aaaacgtctg cccggcgtag cgggaaccca gcatgatttt caggagtctc    480
 tgttgcccag gctggaatgc aatggtgcgg tctcggtcac tgcaacctct gcctcccggg    540
 ttcaagcgat tatcctgctt cagcctcccg agtagctgga attgcgggca tgtgctacca    600
 cacctggcta atttttgtat ttttagtaaa gacggggttt ggccatgttg gccgggctgg    660
 tctcgaactc ctgacctgag gtgatctgtc cgcctcagcc tcccaaagtg ctaggattat    720
 aggcttgagc caccgcgccc ggcctatttc tgagtgttta ttgtaaaaac tatagttttt    780
 aaagtttgcc agatgcaata aaa                                            803



      <210> 1263
      <211> 803
      <212> DNA
      <213> Homo sapiens


      <400> 1263
 acgtacgtat gagcaaccgg cctttatttc ccgggacgac gatttcttct gagaaagaac     60
 gacaggttca gagacgccgc taggattaag tttaagactt cgcgagaaca gaatttcttt    120
 tggcacctcc tctccgcgcg ttcttggggt gaggctgggt aattgttcct gcagggtggt    180
 gggtgatagt ggccagttga ctgcgactgt gtttgggtgg tgggaagcct gaagaaaagg    240
 ttgtttctta ccggtcgctg cctcagggag gtagtgcggt agaattttcc gctatgggtc    300
 attctcggtg tccgcgggga agggcgtgac aacgacgggc gtgacggcga agcaacagtg    360
 tctcgagagc gctgccgccc ggagggcgcc aggagaagtg cgtccgagac gccgcgcggt    420
 gatgctcctg aaaacgtctg cccggcgtag cgggaaccca gcatgatttt caggagtctc    480
 tgttgcccag gctggaatgc aatggtgcgg tctcggtcac tgcaacctct gcctcccggg    540
 ttcaagcgat tatcctgctt cagcctcccg agtagctgga attgcgggca tgtgctacca    600
 cacctggcta atttttgtat ttttagtaaa gacggggttt ggccatgttg gccgggctgg    660
 tctcgaactc ctgacctgag gtgatctgtc cgcctcagcc tcccaaagtg ctaggattat    720
 aggcttgagc caccgcgccc ggcctatttc tgagtgttta ttgtaaaaac tatagttttt    780
 aaagtttgcc agatgcaata aaa                                            803



      <210> 1264
      <211> 728
      <212> DNA
      <213> Homo sapiens


      <400> 1264
 gtccccggct cctgatggag gcggggccgc atccccggcc ggggcactgc tgcaagcctg     60
 gggggcggct ggacatgaac cacggcttcg tgcaccatat ccgacggaac cagatcgctc    120
 gggacgacta tgacaagaag gtgaagcagg cggccaagga gaaggtgagg aggcggcaca    180
 cgcccgcgcc gacgcggccc cgcaagccag acctgcaggt gtacctgccg cgacaccgag    240
 atgtctctgc ccacccacgc aacccagact atgaagagtc cggtgaaagc agcagtagtg    300
 gaggctctga gctggagcct tctggccatc agctcttctg cttagaatac gaggcagaca    360
 gtggagaggt cacatcagtt atcgtctatc agggtgatga cccaggaaag gtgagtgaga    420
 aggtgtcggc acacacgcct ctggatccac ccatgcgaga agccctcaag ttgcgtatcc    480
 aggaggagat tgcaaagcgc cagagccaac actgaccatg ttgaaggcgt tctctccagg    540
 ctggattcac tgcactcgga agaattctgc ccagggaatt tagtgtgggg gtaccaggac    600
 cagtttgtct gatcttgaga cccccagagc tgctgcatcc atagggtgtt gcaggactac    660
 acctggcctg ccttgcagtc cattctttct tatatgttga cccatttgcc cagcctgata    720
 ttctggaa                                                             728



      <210> 1265
      <211> 1190
      <212> DNA
      <213> Homo sapiens


      <400> 1265
 gcggccgccg tggccgagct gccggtgctg gacgcccgcg ggcagcgggt acccgttcgg     60
 cgcgctgttc cgggagcgcc gcgccgtggt ggtgttcgtg cggcatttcc tgtgttacat    120
 ctgcaaggaa tacgtagagg atctggccaa aatccccagg agtttcttac aagaagcaaa    180
 tgtcaccctt atagtgattg gacagtcatc ctaccatcat attgagcctt tttgcaagct    240
 gactggatat tctcatgaaa tctatgtcga tcctgagaga gaaatttata aaagattggg    300
 aatgaaaaga ggtgaagaaa ttgcttcctc aggacagagc ccccacataa aatcaaatct    360
 actctcagga agccttcaga gcctgtggcg ggcagtgact ggccctctct ttgattttca    420
 aggagaccca gctcagcaag gtggaaccct cattttaggt ccaggtaaca acatccattt    480
 tatacaccgc gataggaata ggttggatca caaacctatc aactctgttt tacagcttgt    540
 aggagttcag catgtgaact ttacaaacag accttcagtt atccatgtgt gacttaaaat    600
 gcactcagtc actttcaact ggaccttctg gaatgtgacc ttcaatgcct gggtgtaata    660
 tcctcgtgca gtgtctaacc tgctgtccct tcccagcctt tgaggagtta gggaagcata    720
 aagggggctt gaacctgttg aattgcatgc tgggaagcat cagttgtcaa aatatgttat    780
 atacttccat tttataactt ttaacatttt atacaaaaaa aatgaatata caaaatataa    840
 ctttaaaagc tataaaatca taaatactct aaattatttt acattatggt atattcagtc    900
 aatgaaagag ttttttggca atataaattc tgacagtata taaggggaca ggagaacaac    960
 acaagaccat tatattcagt gaagaaggca aaatatcaaa tctgtcaaca atgtaactgc   1020
 atttttatat gtatatattt gtatttttgt atgctttgga aaaagacagg aaataaacac   1080
 caaaatgttg ccagtaggta tctctgtgtt aagattagcg ctattatttt cttttctgta   1140
 cttttctgta tttcccaact gttatataat gagcatgatt aatattgtag              1190



      <210> 1266
      <211> 1190
      <212> DNA
      <213> Homo sapiens


      <400> 1266
 gcggccgccg tggccgagct gccggtgctg gacgcccgcg ggcagcgggt acccgttcgg     60
 cgcgctgttc cgggagcgcc gcgccgtggt ggtgttcgtg cggcatttcc tgtgttacat    120
 ctgcaaggaa tacgtagagg atctggccaa aatccccagg agtttcttac aagaagcaaa    180
 tgtcaccctt atagtgattg gacagtcatc ctaccatcat attgagcctt tttgcaagct    240
 gactggatat tctcatgaaa tctatgtcga tcctgagaga gaaatttata aaagattggg    300
 aatgaaaaga ggtgaagaaa ttgcttcctc aggacagagc ccccacataa aatcaaatct    360
 actctcagga agccttcaga gcctgtggcg ggcagtgact ggccctctct ttgattttca    420
 aggagaccca gctcagcaag gtggaaccct cattttaggt ccaggtaaca acatccattt    480
 tatacaccgc gataggaata ggttggatca caaacctatc aactctgttt tacagcttgt    540
 aggagttcag catgtgaact ttacaaacag accttcagtt atccatgtgt gacttaaaat    600
 gcactcagtc actttcaact ggaccttctg gaatgtgacc ttcaatgcct gggtgtaata    660
 tcctcgtgca gtgtctaacc tgctgtccct tcccagcctt tgaggagtta gggaagcata    720
 aagggggctt gaacctgttg aattgcatgc tgggaagcat cagttgtcaa aatatgttat    780
 atacttccat tttataactt ttaacatttt atacaaaaaa aatgaatata caaaatataa    840
 ctttaaaagc tataaaatca taaatactct aaattatttt acattatggt atattcagtc    900
 aatgaaagag ttttttggca atataaattc tgacagtata taaggggaca ggagaacaac    960
 acaagaccat tatattcagt gaagaaggca aaatatcaaa tctgtcaaca atgtaactgc   1020
 atttttatat gtatatattt gtatttttgt atgctttgga aaaagacagg aaataaacac   1080
 caaaatgttg ccagtaggta tctctgtgtt aagattagcg ctattatttt cttttctgta   1140
 cttttctgta tttcccaact gttatataat gagcatgatt aatattgtag              1190



      <210> 1267
      <211> 1190
      <212> DNA
      <213> Homo sapiens


      <400> 1267
 gcggccgccg tggccgagct gccggtgctg gacgcccgcg ggcagcgggt acccgttcgg     60
 cgcgctgttc cgggagcgcc gcgccgtggt ggtgttcgtg cggcatttcc tgtgttacat    120
 ctgcaaggaa tacgtagagg atctggccaa aatccccagg agtttcttac aagaagcaaa    180
 tgtcaccctt atagtgattg gacagtcatc ctaccatcat attgagcctt tttgcaagct    240
 gactggatat tctcatgaaa tctatgtcga tcctgagaga gaaatttata aaagattggg    300
 aatgaaaaga ggtgaagaaa ttgcttcctc aggacagagc ccccacataa aatcaaatct    360
 actctcagga agccttcaga gcctgtggcg ggcagtgact ggccctctct ttgattttca    420
 aggagaccca gctcagcaag gtggaaccct cattttaggt ccaggtaaca acatccattt    480
 tatacaccgc gataggaata ggttggatca caaacctatc aactctgttt tacagcttgt    540
 aggagttcag catgtgaact ttacaaacag accttcagtt atccatgtgt gacttaaaat    600
 gcactcagtc actttcaact ggaccttctg gaatgtgacc ttcaatgcct gggtgtaata    660
 tcctcgtgca gtgtctaacc tgctgtccct tcccagcctt tgaggagtta gggaagcata    720
 aagggggctt gaacctgttg aattgcatgc tgggaagcat cagttgtcaa aatatgttat    780
 atacttccat tttataactt ttaacatttt atacaaaaaa aatgaatata caaaatataa    840
 ctttaaaagc tataaaatca taaatactct aaattatttt acattatggt atattcagtc    900
 aatgaaagag ttttttggca atataaattc tgacagtata taaggggaca ggagaacaac    960
 acaagaccat tatattcagt gaagaaggca aaatatcaaa tctgtcaaca atgtaactgc   1020
 atttttatat gtatatattt gtatttttgt atgctttgga aaaagacagg aaataaacac   1080
 caaaatgttg ccagtaggta tctctgtgtt aagattagcg ctattatttt cttttctgta   1140
 cttttctgta tttcccaact gttatataat gagcatgatt aatattgtag              1190



      <210> 1268
      <211> 645
      <212> DNA
      <213> Homo sapiens


      <400> 1268
 aagatatttt tgagcgactg cctggcatgt gacagctgta tgactgcaga gaaaggagtc     60
 caactttccc agcaaaatgc caaggacttc ttccgcgttc tgaacctaac aagaaatgtg    120
 atacctcaaa gcacaaagtg ctggtagtgt ctgtgtgtcc tcaatctttg ccttattttg    180
 ctgctaaatt caacctcagt gtaactgatg catccagaag actctgtggt ttcctcaaaa    240
 gtcttggggt gcactatgta tttgatacga cgatagctgc ggattttagt atcctggagg    300
 atgcttaaat ggcagaggcc aagcccagac tccagacgga catgcggata aggccctgct    360
 gcggcagatg gaaggcattt acgctgacat ccctgtgcgg cgtccggagt ccagtgcaaa    420
 cgtgcaggag ctgtaccagg agtggctgga ggggatcaac tcccccaagg cccgagaggt    480
 gctgcatacc acgtaccaga gccaggagcg tggcacacac agcctggaca tcaagtggtg    540
 aagtcaggcc agggccttcc agctgctctt ggggccagag ccaagagcct ctcagtagag    600
 ggaggggctg ccctgagtgg agtattaaag acacttaaga aaacc                    645



      <210> 1269
      <211> 1533
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1533)
      <223> n = a,t,c or g


      <400> 1269
 cagatggagc acgtggtcca ggcttgccac cgcttcatcc aggccagcta tgaacctctg     60
 ggcatctccc tgcgccccct ggaagcagaa cccccaacac ccccaacggc ccctccacca    120
 ggtagtccca ggcgctccga aggacaccca gacccaccta ctgaatctcg aagctgcagt    180
 caaggccccc ccagtccagc cagccctgac cccaaggcct gcaactggaa aaagtacaag    240
 tacatcgtgc taaactctca ggcctcccaa gcagggagcc tggtcgggga gagaagttct    300
 ggtcaacctt gcccccaagc caggctcccc agtggagacg aggcctccag cagcagcagc    360
 agcagcagca gcagcagcag tgaagaagga cccattcctg gtccccagag caggctctct    420
 ccaactgctg ccactgtgca gttcaatgtg gggctccagc cagtaccccc tacctcctca    480
 catcccaggc tcaagacacc tctggatcac cctctgaacg ggctcgtcca ctaccgggaa    540
 gtgaattttt cagctgccag aactgtgagg ctgtggcagg gtgctcatcg gggctggact    600
 ccttggttcc tggggacgaa gacaaaccct ataagtgtca gctgtgccgg tcttcgttcc    660
 gctacaaggg caaccttgcc agtcaccgta cagtgcacac aggggaaaag ccttaccact    720
 gctcaatctg cggagcccgt tttaaccggc cagcaaacct gaaaacgcac agccgcatcc    780
 attcgggaga gaagccgtat aagtgtgaga cgtgcggctc gcgctttgta caggtggcac    840
 atctgcgggc gcacgtgctg atccacaccg gggagaagcc ctacccttgc cctacctgcg    900
 gaacccgctt ccgccacctg cagaccctca agagccacgt tcgcatccac accggagaga    960
 agccttacca ctgcgacccc tgtggcctgc atttccggca caagagtcaa ctgcggctgc   1020
 atctgcgcca gaaacacgga gctgctacca acaccaaagt gcactaccac attctcgggg   1080
 ggccctagct gagcgcaggc ccaggcccca cttgcttcnt gcgggtggga nagctgcagg   1140
 cccaggcctt gcttccctat caggcttggg cataggggtg tgccaggcca ctttggtatc   1200
 agaaattgcc accctcttaa tttctcactg gggagagcag gggtggcaga tcctggctag   1260
 atctgcctct gttttgctgg tcaaaacctc ttccccacaa gccagattgt ttctgaggag   1320
 agagctagct aggggctggg aaaggggaga gattggagtc ctggtctccc taagggaata   1380
 gccctccacc tgtggccccc attgcattca gtttatctgt aaatataatt tattgaggcc   1440
 tttgggtggc accggggcct tcattcgatt gcatttccca ccccctctct gaattgcccc   1500
 tgcggacgat gctaggttca ggnnnnnccc gct                                1533



      <210> 1270
      <211> 2466
      <212> DNA
      <213> Homo sapiens


      <400> 1270
 tccggggcgg cccccggcag ccagcgcgac gttccaaaat cgaacctcag tggcggcgct     60
 cggaagcgga actctgccgg ggccgcgccg gctacattgt ttcctccccc cgactccctc    120
 ccgccccctt cccccgcctt tcttccctcc gcgacccggg ccgtgcgtcc gtccccctgc    180
 ctctgcctgg cggtccctcc tcccctctcc ttgcacccat acctctttgt accgcacccc    240
 ctggggaccc ctgcgcccct cccctccccc ctgaccgcat ggaccgtccc gcaggccgct    300
 gatgccgccc gcggcgaggt ggcccggacc gcagtgcccc aagagagctc taatggtacc    360
 aagtgacagg ttggctttac tgtgactcgg ggacgccaga gctcctgaga agatgtcagc    420
 aatacaggcc gcctggccat ccggtacaga atgtattgcc aagtacaact tccacggcac    480
 tgccgagcag gacctgccct tctgcaaagg agacgtgctc accattgtgg ccgtcaccaa    540
 ggaccccaac tggtacaaag ccaaaaacaa ggtgggccgt gagggcatca tcccagccaa    600
 ctacgtccag aagcgggagg gcgtgaaggc gggtaccaaa ctcagcctca tgccttggtt    660
 ccacggcaag atcacacggg agcaggctga gcggcttctg tacccgccgg agacaggcct    720
 gttcctggtg cgggagagca ccaactaccc cggagactac acgctgtgcg tgagctgcga    780
 cggcaaggtg gagcactacc gcatcatgta ccatgccagc aagctcagca tcgacgagga    840
 ggtgtacttt gagaacctca tgcagctggt ggagcactac acctcagacg cagatggact    900
 ctgtacgcgc ctcattaaac caaaggtcat ggagggcaca gtggcggccc aggatgagtt    960
 ctaccgcagc ggctgggccc tgaacatgaa ggagctgaag ctgctgcaga ccatcgggaa   1020
 gggggagttc ggagacgtga tgctgggcga ttaccgaggg aacaaagtcg ccgtcaagtg   1080
 cattaagaac gacgccactg cccaggcctt cctggctgaa gcctcagtca tgacgcaact   1140
 gcggcatagc aacctggtgc agctcctggg cgtgatcgtg gaggagaagg gcgggctcta   1200
 catcgtcact gagtacatgg ccaaggggag ccttgtggac tacctgcggt ctaggggtcg   1260
 gtcagtgctg ggcggagact gtctcctcaa gttctcgcta gatgtctgcg aggccatgga   1320
 atacctggag ggcaacaatt tcgtgcatcg agacctggct gcccgcaatg tgctggtgtc   1380
 tgaggacaac gtggccaagg tcagcgactt tggtctcacc aaggaggcgt ccagcaccca   1440
 ggacacgggc aagctgccag tcaagtggac agcccctgag gccctgagag agaagaaatt   1500
 ctccactaag tctgacgtgt ggagtttcgg aatccttctc tgggaaatct actcctttgg   1560
 gcgagtgcct tatccaagaa ttcccctgaa ggacgtcgtc cctcgggtgg agaagggcta   1620
 caagatggat gcccccgacg gctgcccgcc cgcagtctat gaagtcatga agaactgctg   1680
 gcacctggac gccgccatgc ggccctcctt cctacagctc cgagagcagc ttgagcacat   1740
 caaaacccac gagctgcacc tgtgacggct ggcctccgcc tgggtcatgg gcctgtgggg   1800
 actgaacctg gaagatcatg gacctggtgc ccctgctcac tgggcccgag cctgaactga   1860
 gccccagcgg gctggcgggc ctttttcctg cgtcccagcc tgcacccctc cggccccgtc   1920
 tctcttggac ccacctgtgg ggcctgggga gcccactgag gggccaggga ggaaggaggc   1980
 cacggagcgg gaggcagcgc cccaccacgt cgggcttccc tggcctcccg ccactcgcct   2040
 tcttagaggt ttattccttt ccttttttga gatttttttt ccgtgtgttt attttttatt   2100
 atttttcaag ataaggagaa agaaagtacc cagcaaatgg gcattttaca agaagtacga   2160
 atcttatttt tcctgtcctg ccccttaagg gtggggggga cccgggcccc tctttaggga   2220
 ccccttggcc caagcctcat tccccatttt gtgtcccatg tcccggtgtc tcctcggttg   2280
 ccccggggtt tgggcttgac catgttgcac tgtttgcatg cgcccgaggc aaacgtttgt   2340
 caggggcttg gatttacgtg tgccgctgcc acccgcccac ccgccttgtg agatggaatc   2400
 cgtaataaac cacgccatga ggacaccgcc gcccgcctcg gcgcttcctc caccggaaaa   2460
 aaaaaa                                                              2466



      <210> 1271
      <211> 3500
      <212> DNA
      <213> Homo sapiens


      <400> 1271
 taattattgt tttctttttt ttttcaacta ataatggcct tttttattta tgtggttgga     60
 aaggttaaaa taggtgacac gtgaaaagtg ccttgcacat agaaagcact ctattaattg    120
 agggggatat tattgttact gttcattgtt agtagtagca ttaaaactga tatgattgct    180
 aatgaagaaa cagacttaaa gaggaagcaa acctcgaaca gatgccacaa taaagcaaca    240
 aaattgctga ttcttcaggg ctctttctac aggacagagg gactagagct tactctccct    300
 gaggttctct tgctgtttac tttggaagct ctgacctttc cagcagacac catcacctgt    360
 gccctgcagg gagcagagat tcggactttt taagtttccg cttctggctg ggtctgtggc    420
 ccttgtctag gctctgctaa aacagatggc aaacacggcc actcagtagg tgtctttatt    480
 catacttgtt gacatttccc atggggaatg gttgaaggga ggggcaggga gggctgagcg    540
 ggaagccacg gcttggtttt cctccatcca gtggagaaga gactcggtag ggacatgcta    600
 agtagagtga acaggggaac catcactatg tgggctgaga tgcactgtgc agtgacttca    660
 gacaacctga gtccttctgt caggaaatgc aatttctaag tggaaaaaaa aaacaagacc    720
 caaagaaaaa aacaaagtgc atacaaagca aactgctaat gtaagaaagg ttctaaggca    780
 gccagcagtg aaaagccagg ggtctggagt ggccacctgg ccatgccctg tcccactgcc    840
 ctgtgccagg ctgtcgggcc accagtgccc tcttgagaca gtctccattg gctccaaggg    900
 ttctgtgagc cacagaaggt tgtgaaagga gaagagcctg aagtgtggca gcaccagggc    960
 agcccaaagc agggctgcgt tgaaaatatc aaagtatctc tttaggggtg gctctgaggg   1020
 ttggtgggat tggaggggga aggggcgcct gggaggagta cagtcagcat ctattcttgg   1080
 gcaccgggag gagccactct ctggaatctt aaattaccag gtaggagtga gaatgctgat   1140
 tagctgtaga gctgaaggca cggctgccag gcccctccgg gtccttctct agttctccag   1200
 gcccggtgta tcgaaggcag tggagaggaa gggcctgtgg gagccagggc cagctcagca   1260
 gcctagccag tcggatttga tgcttccaaa cttcacgctc ttcagacttt ggttctccag   1320
 cttcaggtaa taggcaccct tgaagaagta gctgtgaccg ccgccctgca ggtccacgac   1380
 ggcatccagg ttatcgggga tggcattcca ggcatctgcg atgagcttgg ggaagccagg   1440
 atccattttc ttcttcacct cattgtatct ccagaatttg tctccagcaa agatgtatgt   1500
 cttcttgttt ttgctccagt taaaggcggc atccactcgc tggacatcag ggggcagtcc   1560
 caggctggtc agtggcttgg ggtaccctcg ctccagggtg ctggctgagt agatccagta   1620
 ttcattccct gcaaagaaca cagccttctc ctcctgtggg gcctcgtata ccgcatcaat   1680
 cttttccggg agctcaggcc agaatgtggc caccagcagg ggccccatgg gcttgtcacg   1740
 tggcgtcaca gtccgccaaa tgaaccggtc cttgaagaag aagatctcac cacggatctg   1800
 agcgatgcca tcaaatacaa tgtcctgttt gcagatctca ggagtgacag ggcccagcgt   1860
 gggggtgggg ccggtgccaa ggtcaatgtc aggagaggcc ccatagagct cctgaatgcc   1920
 cttgatgtca tcctgggaca gacggaagtt cttggtgtag gtgtaaatgg gtgccatcag   1980
 ggccccaggg tcttgggagt gctccagccc catggcgtgg ccaaactcgt gggctgccac   2040
 gaggaacagg ctgtaccctt ggtcagggca gaagccccac ttgcggtcgt catcgtagtt   2100
 ggctgtggtc gcacaccaca tctttccgtc actgcggccg gcgctggtgc agctctcata   2160
 tttgttgccc aggaaagtga aggggaagac acagggggca ccttctgagt tcccaccaac   2220
 agtggacatg gcggtctcag ggcagaagcc atacttcttg tcgcggtcgt agtcctcagt   2280
 ggtgccgcac cagcggtagc catccgtgcg gccctcagtg gtgcagctgt cataggatgt   2340
 gccctggaag cggaatggaa acttgcaggg ctgtccttca gcgttgccgc ccatggtgaa   2400
 cagggcttca tggggacaga agccgtactt gccatccttc tcaaagttgt aggtggtgga   2460
 gcaccagagg aagccatcgc tgcggccggt atcagtgcag ctgttgtact ccttgccatt   2520
 gaacaagaag gggaacttgc agtactcccc atcggcgttc ccatacttca cacggaccac   2580
 ttggccttct cccaaggtcc atagctcatc gtcatcaaaa tgggagtctc ccccaacacc   2640
 agtgcctggg gcgaaggcat gagccaggag tccgtcctta ccgtcaaagg ggtatccatc   2700
 gccatgctcc cagcggccaa agttgatcat gatgtctgcc tctccatcat ggattcgaga   2760
 aaaccgcagt ggggtcacat cgctccagac ttggaaggca cgagcaaagg catcatccac   2820
 tgtctctggg tccagatcag gtgtgtagcc aatgatcctg tatgtgatct ggttcttgtc   2880
 ccacttgggc ttgcgaggga agaagttgta gttggccaca tctgggttgc cgcagcgtgg   2940
 cttccgcatg gtctcgatgg tattctggtc aagatcacct gtctggggca gtccaaagaa   3000
 cttctgcatc ttctttagtg tgtccttcag cacaaacagg ttgcagctct ccttggggca   3060
 gccatagaag gtgttcaggt attgcactgc caactctttg tccgttttgg gggcgacatc   3120
 gccggggaac ttgatgatgg gcgacggcgc ggcggcggcg tggctcagca ggcagcccag   3180
 gagacagagc gccctcaggg gacccgtgag cgcggccccg ggccattagc gcctccatcg   3240
 tagcgctccc tggccccgcg cgtcgcccgg gggtcgctgg ctcggtgcgt gtggccgcct   3300
 cgccgcctgg ttggagcctg ctccgcggcg cagggctgcg ctccgagggt ccgctggctc   3360
 ggtggcctgg ggtttgcccg gctcagcggc tcatggtccg gcccccgcgc cccagccccc   3420
 gccgccgccg ccgccgccgc aggtcctggc aatccctttg tatgtttaaa gccccagatg   3480
 cgcagcctcc agccaccgcc                                               3500



      <210> 1272
      <211> 455
      <212> DNA
      <213> Homo sapiens


      <400> 1272
 tttaaacatt tgtgatttga ttttatctca gcttggaatg tggttggagt gtcccacttc     60
 taacaactgt ttgctaagtt aaggctttgg tgtttacaca gtgttgaatg aagcagcctg    120
 gtcaccagat gtgatcgctt ccccagactg tcgttttttt tcaatcagat cactgtcctc    180
 atggtcccgg ttccaacctt cttcctcagt acatccacca gcctttccaa cttttgaact    240
 ttttcattgg ccacttggga ggcctctctg gcatgttgaa gttgtaattc catatttgct    300
 cgctctgtca gagcttgttg cagttgagta gccagttcct cattttgttg ttgagtgatg    360
 gaaacaatgt tctctctgtt ttttaaagct tcttcatatg tactaagggt atagttaaac    420
 tgatccttca gattttcttc ttgagataaa gattt                               455



      <210> 1273
      <211> 491
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(491)
      <223> n = a,t,c or g


      <400> 1273
 gcgggggcaa tgcgaaccta gtncgtgtgg tggaattcga ggattgcttt aaggcactga     60
 tttggataag gaataactcc atcaccacag aagggaatat cattgtctat gggaatacaa    120
 ttgatactta caccaccgtg gagacgctct taaaccttgg cgtgagcggc agccgcatcc    180
 acctcgtgca gcccccgccc gcccccacca tcacctgcat caacaactac tcggtggaga    240
 gcgccgtggc ggacgcgcta ggagccgccg gagtcactat gtaccgggat gcgatcctgg    300
 cccagtggaa tgacggcctg cacccagacc ccatctacag cgcctccttc accacaccca    360
 ccaagccttt cagactccag tgctctatgt tcttcagctt ctgtgagaag aatgtggatt    420
 atgaaacgtt taaagccctc aatgatgcat gtcttgtgta tgacagtcga cttgtgattg    480
 ataccaactt c                                                         491



      <210> 1274
      <211> 733
      <212> DNA
      <213> Homo sapiens


      <400> 1274
 tgcagagaca tggctgcatt tattgttccc agcccggcga gaaggtgttc ccagaaaggt     60
 tccttgggtc acctgcccac ccagccttgg ctctgggctg ccatgtcccc acgggggcag    120
 gagagaggca caagtcacag tcaggcaagg gagcctcagc gtcctgggcg gtggctgttg    180
 gggtccctcc agtcttcacc tgggaccctc ggccaggctg ggacagcatc caggaggcga    240
 ggctgcatgg tccagcggtg ggtgcaggtg gcaacaggtc ggcgggctgt gcaggttcca    300
 aaaggagctc tcgggttggc actgggtgag accagccccg gggccagcag gggaatgagc    360
 ggtggagcag ggggttgctg ggcactgggg tgggccccat ctcctgtcct tccctcatgg    420
 ctgctggaag ggccgcctcc ctggctcagc atcatctcag attccgggac tcaaagaccg    480
 tctcctcgtc gctgtccagc gaggccatct ccgtggggtc ctcagtgttg gcgaggaggc    540
 cgtatcgcct ccgctgaggc ttcttcaacc taaacgcccg gatcaggaag tagagcgcgg    600
 tcaggccgca gaagcccagg atcacgtaga aggagcgcgt cagcgccgag cccgacgccc    660
 ccgacggacg cgtgtgcgtg aagttgtgtg gcgcgcccgg ctggctcccg ttcgtcacgg    720
 ccggcggcgg cga                                                       733



      <210> 1275
      <211> 857
      <212> DNA
      <213> Homo sapiens


      <400> 1275
 tttcgtgccc tggctccagc atccacggca tcaggcgcag cctctgtggg acagacatca     60
 gctagaaaga gggatgcccc agcccctaga cctctccctg cttctgaggg gcatctccag    120
 cctccagctc agacatctgg tcctacaggc tccccaccct gcatccaaac ctccccagac    180
 cctcggctct ccccctcctt ccgagcccgg cctgaggccc tccacagcag ccctgaggat    240
 cctgttttgc cacggccacc ccagaccttg cccttggatg tgggccaggg tccttcagag    300
 cctggcactc actcccctgg acttctgtcc cccaccttcc ggcctggggc cccctcaggc    360
 cagactgtgc ccccacctct gcccaagcca ccccgatcac ccagccgttc cccaagccac    420
 tccccgaatc gctctccctg tgttccccca gcccctgaca tggccctccc aaggcttggc    480
 acccagagta cagggcctgg caggtgcctg agccccaacc ttcaggccca agaagcccca    540
 gccccagtca ccacctcctc ttctacatcc accctgtcat cctccccttg gtcagctcag    600
 cctacctgga agagcgaccc cggcttccgg atcactgtgg tcacatggaa cgtgggcact    660
 gccatgcccc cagacgatgt cacatccctc ctccacctgg gcggtggtga cgacagcgac    720
 ggcgcagaca tgatcgccat agggttgcag gaagtgaact ccatgctcaa caagcgactc    780
 aaggacgccc tcttcacgga ccagtggagt gagctgttca tggatgcgct aagggccttt    840
 cacttcgtgc ttgtgag                                                   857



      <210> 1276
      <211> 1129
      <212> DNA
      <213> Homo sapiens


      <400> 1276
 tttttttaaa agcaatttat ttctgattac aaaatacagg tgaggagcat gggcgatgcc     60
 tgtaacccct tggttgtgca tcttcccagt ctatttctgc ttctagaaat accctgtgta    120
 caacagcaag ctcatgctgt ccccaagtgc ttgcacattc taacagctgc agagtatatg    180
 accaggtgga aagtccaaca gatgccccac tcacaagata gggccctcca atcagtcttc    240
 tggctccctt tcactcatag taactggttg ctcttcctat tggtcataga taaatgacac    300
 ctgcacaatt ctccgagtgc tttcaagcaa cttcgggagg cagtgactaa gaccctttcc    360
 ttgctcccag cttcctatgt cccagggctg cctgtggcac ctggactgct gctgcccctg    420
 ggtcccgtac attccagggc aacaatggag gaagggcagg caacgcatga ggaattaaca    480
 gtctttattg ggctcagacc aggagtccgt gggtcttgag gacctctgtg tatttgtcaa    540
 ttttcttctc cacgttcttc tcggcctgtt tccgtagcct catgagctgt ttcttcttcc    600
 ggtagtggat cttggctttc tctttcctct tctcctccag ggtggctgtc actgcctggt    660
 acttccagcc aacctcgtga gccaggcgcc ccagataggc aaactttctt gtaggcttca    720
 gacgcacgac cttgagggca gcaggaacca ccatccgctt tttcttgtcg tagggcggtg    780
 ggatgccgtc aaacaccttg agacggtcca gagcggcctg gcctcgcttg gttttgtggg    840
 gcagcatacc tcgcacggtc cgccagaaga tgcggctggg ggcccggaag tggtaggggc    900
 ctcgggaagg gttggtgttc atccgcttgc ggaggaaagc caggtacttc aacttgtttc    960
 tgtagaaatt gccagaaatg ttgatgcctt cacagcgtac gaccaccacc tttccggccc   1020
 agcagtaggc tggtttagcc ccgatggccg gccaggcggg cccaggagat gggcctcgac   1080
 catcaaagca ccaggacctg cacctccgcc atcttcggca gccgcttgg               1129



      <210> 1277
      <211> 466
      <212> DNA
      <213> Homo sapiens


      <400> 1277
 ttttgatact gcccggctgc acgaattcgg cacgagtata actcagattt ttgcagttga     60
 caatagagaa gatcttcaga agtggatgga agccttctgg cagcatttct ttgatcttag    120
 ccaatggaag cactgttgtg aagaacttat gaaaattgag attatgtcac cacggaaacc    180
 acctttgttc ttgacaaaag aggcaacctc agtctaccat gatatgagca ttgattcacc    240
 tatgaaactt gaaagtttaa cggatataat acaaaaaaaa attgaagaga caaatgggca    300
 gttccttatt ggtcagcgtg aagaatcctt accacctcct tgggccacac tctttgatgg    360
 taaccatcaa atggtcatcc agaaaaaggt actgtatcct gcaagtgagc cattacatga    420
 tgaaaaaggg aaaaagagac aagctcccct tcctccttct gataaa                   466



      <210> 1278
      <211> 428
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(428)
      <223> n = a,t,c or g


      <400> 1278
 gctggcgaac caggcactga accgccgccc ccgctaccgc agcagccgcc gatgacgctg     60
 cctcctctgc agccgccgct gccaaccccg gggcccctgc agcccgggct ccaccagggc    120
 caccagtgat cgaggataag ggtcctccca gcctcagccg tgcccccacg ctgaggcagc    180
 ggcagactag agctcctggt ccgagttcgt ctgcagaccc cagggcatgt tgggccccac    240
 acttcagggc cgaccagaag cctctgcatc ccctggcctt tcgcctcttg catgcacctg    300
 ctaaatggtt ttgtgtatta tattctatat aggcactaac aattatgaaa aatttggagg    360
 gntttgcttg gtttnnnnnn nnnnnnnnnn nnnnnnnnaa tttggaaaga cttttcatct    420
 tgggtgga                                                             428



      <210> 1279
      <211> 929
      <212> DNA
      <213> Homo sapiens


      <400> 1279
 ggtggaattc cccactacct gcggggcgtg aacaacgcgc gccagccgtg gcacaacgcg     60
 gatgtccggc tgcggtacgg gctgcggccg gggaacgcca cggaggaggg cctggccagc    120
 ctgcacagcg tgctgttccg caagcagccg ttcctgtggc gcgctgcact gctctactac    180
 accatccacc gcgccgcgcg catgtccttc cgtcagctct tccaggacct ggagcgctac    240
 gtgcaggacg ccgatgtgcg ctgggagtac tgcgtgcgcg ccaagcgcgg ccagaccgac    300
 acctcgctgc caggttgttt cagcaaggac caggtgtacc tggacggcat cgtgcgcatt    360
 ctgcgacatc gccagaccat cgatttcccg ttgctgacct cactgggcaa ggtgtcctat    420
 gaggatgtgg accacctgcg gccccatggg gtgctggata atacccgggt gccccacttc    480
 atgcaggact tggcacgcta ccggcagcag ctggagcaca tcatggccac caaccggctg    540
 gatgaggcgg agctgggtcg cctgctaccc gactgatgtc cgttgagggc tgcagtcaga    600
 ggccctggac agaagctcca gataggcccc tagaacatga agcagtttgc tctgtgcgtc    660
 cacggcctag gtgtttcttg ggggtgttgg gagggcagga gcattccttg aggaggagtg    720
 gcaacatcaa agtgtttgtg tcccttgcca gcctccctgg ggtctgggga cctgcagcag    780
 catgtctggc aaactgagtc gccctcctgc ctccagctct ctgttgagca gagggaaggc    840
 atgggggcag gaagagagct gagcattgat ggggatgggg gtggtttggg aatagaaact    900
 tgttcttgca tgagatggct ttggatgcg                                      929



      <210> 1280
      <211> 1455
      <212> DNA
      <213> Homo sapiens


      <400> 1280
 tttaatcgga agcaaaagca atacatgtgt atagttttta aaaatcaaac agtagaaaaa     60
 ggacatataa tgaaaagtaa tagaactgtc cctccttctc aactcttgct tccccaaatc    120
 agaaacacaa acttctacac ggtgcttgtt tagagattac accccctttt tcaataacat    180
 gcctttatta ctatttcttg acttaatgac atgaggcatt ttctgctgac ttcctgccgc    240
 ccccctcagc tctccttccc cctgaatata gtcatatcac taatttttaa ctcttctgtt    300
 ggctacctgg ttcaatgaat agcaaagtgg aatgctctga ttggattttc tcatcaccga    360
 ctccagagtc ttgatccatg tgccaatatt caaacagatt ccctttctca cactttcggc    420
 aactgttcaa aaccatgcca catctgaggt tgcttcatat gtgaaacata agtttcttgc    480
 acagttttta atgttcttcc ctgtagtttc tttctgtcat tttttttcct ttgggttgaa    540
 gaaatgtatg ccttccagaa catgttatta atgtcctcca gcttattatt caatccatct    600
 attgcttaga attcatctca ttcaattggg tctattcact tcgtttctaa ttggggagat    660
 ttgcctgctg tctgagccat tcttgttcag tttatctttc cttaagtttt tagttacctt    720
 tccccgtttt ttttttttta ttgcattctg tgcccattgt catttcctaa agttcgtgct    780
 gttttctgtt ttacggatgc aaaaacttct cagatatttt taaggatttt caaattttta    840
 agctgtattc tgttccttca aatatttcct tgagagtcaa tttttcattc tatcttagac    900
 gatttgggtt atatttcagg ctttccacaa atgctgtttt tttctttttt tgccacccat    960
 ttatactaaa agatgaggca atggaaagaa tgagtggcaa gtctgcatgc aggagcggag   1020
 ttggtcgctt tgctctaggg tgggtgagca ggtgggtgga agtcagccat cctgacgagg   1080
 agcccccaaa tgccacaaag ttagtggctc taaatatata cctgcaggtg gacgttgaga   1140
 atcaccgagg ccagaatata gaagtaaaag aagttcttgc gcagccgcca ggccaggtcg   1200
 aagaaggtga gcagcgtgcg cgtgagcgtc ttgcagaagg cgccgtaaga gccgcgggtc   1260
 ccctgcgggc gcgacagccg caccgccagg ccagacaggg ccgccgccgc catggacctg   1320
 atgctgcctc ccacatagtg cccagagccc aaggcctcca tcaggctccg ctgactcacc   1380
 gaccgtggga cagagggatg gacgcgggaa agtacgggcg ggaggcctcc tgggctgctg   1440
 ctgatccgag ctgcg                                                    1455



      <210> 1281
      <211> 685
      <212> DNA
      <213> Homo sapiens


      <400> 1281
 atgaggaggc gcttccttct gcctgtccat ggcccacagc aaaggaatgt ctgcttctgg     60
 gggttggatg ggggactgct ggcagaactg gaaaccttct tcagaaccaa tcggaactcg    120
 aggcgcagcg gctgggtatt ccaggagagc gcatgcgcag acgcatggcc acagactgcc    180
 ggtcagtgtc agcaggcggg tccgcaggcc cagaccaggc cgccgacacc aataagctac    240
 aaggaggagc tttaccgctg cctgtactac tactgcctgc gctacttccc agcctgcggc    300
 gtagggcgca gcaagggcct gacgcttagc gagcaggcgc tgcgcaccaa gcgggctgtc    360
 gcctggaggg cacgttcagg cagaagctcc tcagtggcca caagtccgct agctccggct    420
 acagcccttg ccgcacactc gcgtcacctg agcctgtgta ggatgccgaa ggacctgttc    480
 aaagtatttt ctgtaactcc aactgtaact tggttctagg aggagagaat ccatgtttgg    540
 tcaacagaac ttttcgccgc cacttaagtt tactgcttca atatcttttc cttactaatt    600
 gattgttaat taagtagtgt ccaagtgagt tagccttttt agggttgatt aattaaaaga    660
 gcagcaagaa tggcatttta aaaaa                                          685



      <210> 1282
      <211> 342
      <212> DNA
      <213> Homo sapiens


      <400> 1282
 cggacgcgtg ggagacaact ggctttggca tgatttatga ttccctggat tatgcaaaga     60
 aaaatgaacc caaacatagg cgttgcaaga catggcctgt atgagaagaa aaagacctca    120
 agaaagcaac gaaaggaacg caagaacaga atgaagaaag tcagggggac tgcaaaggcc    180
 aatgttggtg ctggcaaaaa gaagtgagct ggagattgga tcacagccga aggagtaaag    240
 gtgctgcaat gatgttagct gtggccactg tggatttttc gcaagaacat taataaacta    300
 aaaacttcaa aaaaaaaaaa aggggcggcc gttttaaaga ac                       342



      <210> 1283
      <211> 2204
      <212> DNA
      <213> Homo sapiens


      <400> 1283
 caaaaattta tataatttta caccgattag aaatactttt tacaagcaag cgtaatcaga     60
 tagttttcgc cttattccag ataaaaattt ttttatttcc attgagcgta tgatttatgt    120
 aggtaggttg tcccaataag tccctcccac agaattaggg ttcataccaa aagtcaccag    180
 ctaggtttat atatattacc atttagggaa gaaattataa tattgcaagt atgggtaaaa    240
 tttgggcccc caaagggttc tttaaaaagg gccccccttt ttttaagtat tttttttttt    300
 tccctctcat cccatttatt aaagaaacag taagaaaaga tacaatgcag gaaaaccacc    360
 aaccatcctt gcacaccagg ccgaacaaag cacagtgatt tcttcccttc atcccccacc    420
 cccaccctaa ttcccatatt cccatccaca tcagtttaaa ttttgaggtt ctttgattga    480
 ttgggagtac cagtgaagag ggagttggat gagtagaggg gccttaaatc tggccacctc    540
 taagtcccag gagaagggag ctgcaggccc agtcagtcaa gcagaaactg cattcggtgg    600
 gtctttcttt gaagtggttg tccatctccc tgttctgtgt tcaagccccc agggaaaggt    660
 atggcagtag aggatgacca ggtccaagct gcccaggtca gagctacgga agcatggtcc    720
 gttcaccaac gccacgtttc tagagagcag tgagctgatt ctccaatggt gagcagggga    780
 ctacatgtga actgggacct gcaggccaat gtatccctga ggaaaagtcc acaagaacaa    840
 ttcaagaaac tagtaagaaa caatgggcag aaagctgtgg gacgaaagca cagcaggctt    900
 ctgggaggct ggagatcctt tctctcaagg gcaggattat tcccacctgc cacagttcac    960
 atgccacaaa taacatctca ccttcagtca agaaaaacgc aaaggaaaaa gatggctcat   1020
 ttgaacttga gcccaagcta tgttcttcag actgtagctc cacaactacc cttttaccta   1080
 agacagcccc tgccaagaac cacagtgcct agaaaccaag gtggtcctgg agggaaaatg   1140
 gtgtttaagg gggcaacatt ccatttgggt acattgcagc cattggaccc cctggtctgg   1200
 ggaaagcagc tgggtttgtg ccagggaggc tccccactct aggaaatggg acgaaactct   1260
 tgcctgcagg gccattcatc cttggaaagg aagctgggtt gagacccagg gtcccagttg   1320
 gccttgtgaa aggagctggg ttgataccca cagggccagc tggagaaggg cccagatgcc   1380
 cggcagctgg cctggggaaa gtaacttgac cagggcctaa tgggccagta gaccttggga   1440
 aggtagttgg acttggaccc tgcaggccag tggcccttgg gaagttagct gggttggggc   1500
 caagtggccc agaggctctt gggaaaatgg ttggatttga gccctggagg ccagcggacc   1560
 tttggaaggt agctgggttt gatgccaatg tgccagaaga ctgagaaaag gcagatgaac   1620
 ctgctcccct gggaaaggga ttggcattta cccccatggg gccaactggc cttgagaaat   1680
 gagctgaatt agggcctatg gggccaggag cccttgacat gggagatgga tttggccctg   1740
 gaaggccaat tccccgagag ctaggacccg agtttgggcc catggggcca ggtactcttg   1800
 ccatggagga tgggcttgtg cccatgtttc cagaagcctg tgagaaagaa gctgaatttg   1860
 ctcctaaaag acctgctgct cttagaatgg gggcaagatc gaggccttga ggtccagcca   1920
 ttcttaagtt aagaccagat cctgtgccca agaggccacc tgctctggca tctagattag   1980
 ggcctgggcc caggccactt ggtcttgggt tgggcccaag gcctgggcct ggaaacacac   2040
 ctgacctggg ggcagggttt gtccctaaaa agcctgatct cagattgggg tttggtcctg   2100
 ggcccaggcc aactggccta ggattgggag gaccattccc agaggttaac agaacaccgg   2160
 ctctcaggtt aggtccagat ccagggccca tgggaccacc acct                    2204



      <210> 1284
      <211> 2513
      <212> DNA
      <213> Homo sapiens


      <400> 1284
 tttttttttt ttaaatttaa aaagatgtcc tcactgcaca agtgatctac gggctacagg     60
 caaggatggg agacggaggc ttcaacacaa ctcattgcac ttagaaccgt tactaaccga    120
 aacaccattt gcttgtcaac aatgtaccct tgacagcagg gagaaacttc tttatagtct    180
 ctgcttcaga caagatttac agctttctcc aaggccagag gccaattgtg accacaagtc    240
 ttgtttcttg tccaccagac ccaatcctct ggcaccttgt accccccgtt cctcagcaat    300
 atgctcggcc taggttccag aggcagctgg aaggaagcag ctatgggctc attcagttct    360
 gtttgcccaa atccagaagc cctaggaaag tcccgtctga gtcttgactc ctgacccttg    420
 cagtggctgg agtcggtact ggtgcacacc cccactccca cggtgtgggt agtgctgtga    480
 attggaaacc gcagataccc tggaggcctg gtagacagct gactgcccag cactgggcag    540
 actgatagtc cgtaagtctg atggcaatga cgacctagag ttctgaggaa aggaggtgga    600
 actcagagtt cctgtgctgg actgagaaac tgaatctgag gttggcgagt ctgagggtcc    660
 ctgcagggta gggctagcag cactagaagg gcagctcctc cttggaagat tgctgccagt    720
 gctgtttcca gaatgtggct ggctgctaaa ataccctggt gtccccgtaa atggggccaa    780
 cgagtctgtg gacacagggt gggcggggct ggaataggac gtggaagaga gggatgattc    840
 tgaagaaccg tgagaggggg ggtttccagg tctcagtgca gtagttcgat aactgtatcc    900
 tggagactgt gtaggatgtc ctctgaaggg ggaggaactc tgctgaagga ggctttgtga    960
 ttctgtccga ggactatcac actgcaggag ctggtagctg tatctggaag ggctgtaaac   1020
 tgttgctcct ttagagagtg ctgagcttaa tgtctctggg ccttctccat ctgcagggtc   1080
 tgagtctttc tctgtgatgt tactctccca tgtgggagag ggctctccct tttgggccac   1140
 cctcacgctg cttcggagga ccttggggat gctccctcct tctcggagtc gttctactga   1200
 tgtgggaacc atccacctac tgctgatatt ctcttgaggt ctgcagtgag atgaagaagt   1260
 gcctctggaa tctgatgggc ttaccgcctc caaatgggac atagaggaat gagatgggga   1320
 gaattttttg tgaggggaag atggagttcg ggctgaggat ccctgcacac catgggcacc   1380
 agtgtcggaa acggagttac tgctgccttg cccagctcct gcagacttgc ttttgctctg   1440
 tgcagagtca cctcccccac cagcagaatt ttccttagct tcttgtttcc gttttcggta   1500
 ctccagcagg gatacttttt tcctctgtgg tgggttctgg ggggcagatg ggactccttc   1560
 acaggccctt tcaccaccag gtgacaagga tccacgagag aggtctttca ttaagccatg   1620
 ttcatatctg ctggaaaatc cttctgcagg ggaacaatat cccccatcca aatgtaaagg   1680
 cttcctatcc cccactagag gagatcctcg atacagtcca tctgctcgag gcatagcatt   1740
 caaaggggag taggcataca tcaagttgaa ctctgtccga aatgcctggt ctgagtttct   1800
 cacgagggtc tgatgtccat ctccacttct gcttgggaaa ccagtctcag aagtgggtcc   1860
 gagggaggga tgaggagcca ggtcagaatg actgagttga gtagggaagg tctatcagca   1920
 cagctgttag tgttggagtc aaggtatcct acttttgcca aatccaggtc ttttcggtga   1980
 caaagctcaa actgtagagg agtgttgcag cgactagcag tagtaagaga tgttgactgg   2040
 tgaaaacatg aggctgtatc catttcgaca ctcctcttct cctgggtgag atgagccagg   2100
 tgtggccagc tggggactct ttgagcctga attgggaggg ggtggtgtga ctggagacag   2160
 aggccgaagt aacttggtga cattctgctc catcagatag cgagacttcc atttctttaa   2220
 tgggctcaac aagtctgcat tgtctttgca gatactagaa gagctactaa tctcattgct   2280
 ttggtatagg tgctgagttc tagtctcttg gggtacagat gatgtttgag tcatcccttc   2340
 ttctaaggct tgttttatcc agcgcttctt acaggagctg aatgtgccat caggcagaag   2400
 gggccttcga cgtctctcag ggataaaggg tgagccaaag cgaatggagg gttttggggt   2460
 gtgcaataac cgggaattgt tagactggta actgtttaag gcggtgcact caa          2513



      <210> 1285
      <211> 658
      <212> DNA
      <213> Homo sapiens


      <400> 1285
 gccatggagt acacagggag caaatatatc ggggaatatg tagatgggag gatggagggc     60
 aaagcaaggt acatcctccc taccgaaaca atatatgttg gggaaatgaa ggatggcatg    120
 tttcacggcg agggaaccct gtacttcccc agcggaagcc aatacgacgc catttgggaa    180
 aacggattgg ccataaaggg cacatatacg ttctcagatg ggctgcacta tgatgagaaa    240
 aactggcatt actgcgacgg ctatgatcgg aggttttaca cagagatcct caatggcttg    300
 aagcctgcag gtatggctca actcaccaat atggacccac ctagaaaaat ccccaagggc    360
 tattacgatt gtggagacgg cttctataac ccagtcacga gggtagtcaa ggactatagg    420
 aaccgctttc taagaaacgc agatgatgac gagcatgagt ggatcacccg tacctgtcga    480
 aagggctagg atgagatcgt gggtcacagg cccgagccgt gaactctgtg gctgcctcca    540
 ccagaggttt ccatctgccc tactagcatt ggctgccctg ggggacgggc tgtagttcta    600
 gaacctgatt ttaactcagg aataaagact ttctgcggtc agtggcaaaa aaaaaaaa      658



      <210> 1286
      <211> 1980
      <212> DNA
      <213> Homo sapiens


      <400> 1286
 tctagggaat ttggccaccc taggcagaaa gtggtaataa cacagtcagc tcttgattgt     60
 tctaatataa tggccaattt gcatattatc cacgtctttg accagttctt ctttcttctg    120
 tggcttttct tttagtcatt acatttacag ctcacccaat atagtacaga agggatattc    180
 aaattttgca acttgttgga tgaagaaggt ccttggggag gagactgaaa ctactgattg    240
 aaaaatcagg tttataaata atttgaacat ttcatttctt tgtaattgac atatacttct    300
 atatataatt atgagtttaa tgaagtgaga taatttaaga tgatcacaca ataaaacttt    360
 acagccaaaa tacaaagtct tcatcttatt ttcctacttc attttttttc atgttcttag    420
 taagtgcatt tttctacttt attttttgaa aagaacattc atttttgaaa agtttatttc    480
 accaaggacc aatcttttgt tgatgttcaa atttaaattg ttctttcata tctgtctcat    540
 aggagaaaaa catgaaaaat tgcttctgtg gtagtttctt ctaggttttc aagtactctt    600
 atagtagcaa ctggttcaaa atactgcttt gtttcaaagc atacagttta gatgtatctt    660
 cactgatgat gggaacattt tcattttgtt cctgagctgt caggtcactt tcactgtcag    720
 atagtgtaca caggagagtg tcattttcat aggttggaaa ataatactcc agttgatccc    780
 acgtctttct atcggggagc agcgaagtgt gtttagtttc ttccatgtga gttcttaagt    840
 ctgctttgga tttgaacttc acatggcagc cataacatct gcattggtga acttgcctcc    900
 gaataaaatt gaccagtttc acttgctgat agaaatttaa tccaagttct gactttattt    960
 tgagaagatc aaattcgtgt gcatcctcca tgtggacata caacttctca attgtttctg   1020
 cttgcttttc acaaaataag cagactgcag aggcagggtg ttcttcccaa tcagaccagt   1080
 catcttcctg atggtccagc aactcccgat catcttccaa ctgaacttct tcccacgatt   1140
 ttccaagttc caaataattg atgacataaa atctgtcata ttctctgttc ttaggattaa   1200
 tcttacgatg ctgttttttc ctcatgtgat ctttaagtgt atttttgtcc ctgaaggtct   1260
 tctcacagta caagcactgc aaattgtcaa gctttttctg taatgtacac aaaaattcat   1320
 tgcagtttac aatgttgtct ggcaatccaa tgttgaaagc atgttctctg gccatgtggt   1380
 tcaaaataac agatctgttt ccaaggaatt cttcattgca aaacatacaa acgccatgaa   1440
 aattggtatc atttcgttct tgctgctgtt gttccagaat ttctctcagt ctctgtttct   1500
 gaagctcttc tctaagaatt ctatcttctg gtaaaacgtc acataacaaa aaataattct   1560
 cttgttcttc aaatggagca gtggaattaa ttcttattac actacaaaaa tctgtgatgg   1620
 gctgttcagt gaaccttttc ctccaatata aaatgtacct ttggaaatca gcaaccaact   1680
 tgacatcagc tatgacaatc ttatgctcaa taatcatgtg cttcagaagt ttgtcttgtt   1740
 cagccacagg aaaatgttct tcacagaaaa tacaaggcac agatggagaa ccttctaaag   1800
 tggtggtgcc acctggactt tctggcaggg aaagcggctc caggatacaa tccttactgt   1860
 ccccataacc tacacccccg actgtgctgc agctcccatc acggtcttcc tgcattcggg   1920
 cgacagcccc ctgggtcttg gaagcagcca ttacccggca gaaaagaacg gacgcgtggg   1980



      <210> 1287
      <211> 532
      <212> DNA
      <213> Homo sapiens


      <400> 1287
 tttcgtgctg gagcttcctt aggaaagccc gaagcttgtg cacggtcaag ccgcgatgtg     60
 caaagcaggg agggctgggt gctcaggcca ttcttgttgc cctggggtag gtccttccct    120
 gggccccaga tggacagcag tgcatcaggg ttttcaaaaa ggggctgctg cctcgcagtc    180
 ctcaggcttg gccatcctct ccttgcagag gcgacgaggt gatcgccgtg gccagcatga    240
 actacgatcc cattgtgtcc aaggtcgctg aggtgctggc ctcaggccgt gccatccgga    300
 agcgggaggt ggagtgagtg tgggtgtggg aagcctgggg gtgggagtag ttccctggag    360
 tactggctaa ggtgcctatg acagccagcc gcccccacaa ccctccaggg cctttcccct    420
 cttggtttgc atcgcctgag gcttacagga ctacagggag gtgtggggca aggatcatgg    480
 tttgagagca ggctggttat gtgttcatgg tggatggaag ggatagagat gt            532



      <210> 1288
      <211> 1883
      <212> DNA
      <213> Homo sapiens


      <400> 1288
 cagtaaccgg gtcgacgatt tcgtctgtga agctccatgt ggtggacatc tgacagcgtc     60
 cagcggagtc attttgcctc ctggatggcc aggatattat aaggattctt tacattgtga    120
 atggataatt gaagcaaaac caggccactc tatcaaaata acttttgaca gatttcagac    180
 agaggtcaat tatgacacct tggaggtcag agatgggcca gccagttcgt ccccactgat    240
 cggcgagtac cacggcaccc aggcacccca gttcctcatc agcaccggga acttcatgta    300
 cctgctattc accactgaca acagccgctc cagcatcggc ttcctcatcc actatgagag    360
 tgtgacgctt gagtcggatt cctgcctgga cccgggcatc cctgtgaacg gccatcgcca    420
 cggtggagac tttggcatca ggtccacagt gactttcagc tgtgacccgg ggtacacact    480
 aagtgacgac gagcccctcg tctgtgagag gaaccaccag tggaaccacg ccttgcccag    540
 ctgcgacgct ctatgtggag gctacatcca agggaagagt ggaacagtcc tttctcctgg    600
 gtttccagat ttttatccaa actctctaaa ctgcacgtgg accattgaag tgtctcatgg    660
 gaaaggagtt caaatgatct ttcacacctt tcatcttgag agttcccacg actatttact    720
 gatcacagag gatggaagtt tttccgagcc cgttgccagg ctcaccgggt cggtgttgcc    780
 tcatacgatc aaggcaggcc tgtttggaaa cttcactgcc cagcttcggt ttatatcaga    840
 cttctcaatt tcgtacgagg gcttcaatat cacattttca gaatatgacc tggagccatg    900
 tgatgatcct ggagtccctg ccttcagccg aagaattggt tttcactttg gtgtgggaga    960
 ctctctgacg ttttcctgct tcctgggata tcgtttagaa ggtgccacca agcttacctg   1020
 cctgggtggg ggccgccgtg tgtggagtgc acctctgcca aggtgtgtgg ccgaatgtgg   1080
 agcaagtgtc aaaggaaatg aaggaacatt actgtctcca aattttccat ccaattatga   1140
 taataaccat gagtgtatct ataaaataga aacagaagcc ggcaagggca tccaccttag   1200
 aacacgaagc ttccagctgt ttgaaggaga tactctaaag gtatatgatg gaaaagacag   1260
 ttcctcacgt ccactgggca cgttcactaa aaatgaactt ctggggctga tcctaaacag   1320
 cacatccaat cacctgtggc tagagttcaa caccaatgga tctgacaccg accaaggttt   1380
 tcaactcacc tataccagtt ttgatctggt aaaatgtgag gatccgggca tccctaacta   1440
 cggttatagg atccgtgatg aaggccactt taccgacact gtagttctgt acagttgcaa   1500
 cccggggtac gccatgcatg gcagcaacac cctgacctgt ttgagtggag acaggagagt   1560
 gtgggacaaa ccactacctt cgtgcatagc ggaatgtggt ggtcagatcc atgcagccac   1620
 atcaggacga atattgtccc ctggctatcc agctccgtat gacaacaacc tccactgcac   1680
 ctggattata gaggcagacc caggaaagac cattagcctc catttcattg ttttcgacac   1740
 ggagatggct cacgacatcc tcaaggtctg ggacgggccg gtggacagtg acatcctgct   1800
 gaaggagtgg agtggctccg cccttccgga ggacatccac agcaccttca actcactcac   1860
 cctgcagttc gacagcgtgt att                                           1883



      <210> 1289
      <211> 2410
      <212> DNA
      <213> Homo sapiens


      <400> 1289
 caatgttagc ctcaagcaag aggatgaaca gttcttcacg ttctcaaatc cttctaaggt     60
 ggaagtcaga caaggctcag agtggaccct acaatgttga gaaggaaatc cttacttcaa    120
 gattcttgcg tgacactgag acctgtcgac agaattttag gaattttcca tacccagacc    180
 tggctggtcc tcgaaaggca ttgagtcaac tccgagagct ctgccttaag tggctgagac    240
 ctgagattca ctcaaaggaa caaattttgg agctgctggt gctggagcaa ttcctgacca    300
 tcctgcctgg tgaggttagg acttgggtaa agtcccagta tccagagagc agcgaggaag    360
 cagtgactct ggtggaggat ttgactcaga ttctagaaga ggaagctcct caaaactcta    420
 ccctttccca agatacccca gaggaagacc ccagaggaaa acatgctttc cagacaggat    480
 ggctaaatga cttggtgacc aaagaatcga tgacattcaa agatgtggct gtagacatca    540
 cccaggagga ctgggagtta atgcgtcctg tgcagaagga attatacaag actgtgacgt    600
 tacagaacta ttggaacatg gtttctctgg gacttacagt gtacagacca actgtgattc    660
 ccatattgga agaaccatgg atggtgataa aagaaatttt agaaggccct agtccagaat    720
 gggaaactaa agcccaagca tgtactccag tggaggataa tgtctaacct cacaaaggaa    780
 gaaacccata ccatcaaatt agaagactca tatgactacg atgatagact agagaggcga    840
 ggaaaaggtg gcttctggaa aattcacact gatgaaagag gtttcagttt gaagtcagtc    900
 ctttcacaag aatatgatcc tacagaagaa tgtcttagta aatatgatat atatagaaat    960
 aattttgaaa agcattcaaa cctaattata caatatagat acccaattag ataataaaac   1020
 tttctatgta taatgaaggc agggcaacct tcaatcatgt ctcatatggt attgtacata   1080
 ggaaaatact tcctggagag aagccttaca agtgtaatgt gtgtgggaaa aaatttagga   1140
 aatacccatc cctcctgaaa caccaaagta cccatgccaa agagaaatcg tatgaatgtg   1200
 aagaatgtgg gaaagagttt aggcatatct catcccttat tgcacatcag agaatgcaca   1260
 ctggagaaaa accatatgaa tgccaccagt gtggtaaagc cttcagccag cgtgcacacc   1320
 ttactataca tcagagaatt catactggag agaaacccta taagtgtgat gactgtggga   1380
 aagacttcag tcagcgtgca caccttacca tccatcaaag gacacatact ggagagaaac   1440
 catataaatg cttggaatgt ggtaaaacct tcagtcatag ttcatcactg attaatcatc   1500
 agagagttca tactggagaa aaaccttata tatgcaatga atgtgggaag actttcagtc   1560
 agagtacaca ccttcttcag catcaaaaaa tacatactgg gaagaaacca tataaatgca   1620
 atgaatgttg gaaagtgttt agtcagagta cttaccttat tcgacatcag agaattcatt   1680
 ctggagagaa gtgttataaa tgtaatgaat gtggaaaagc ctttgctcat tcctcaaccc   1740
 ttattcaaca tcaaaccact cacactggag agaaatccta tatatgtaat atatgtggga   1800
 aagccttcag ccagagtgca aatcttactc aacatcatag aacacatact ggagagaaac   1860
 catataaatg cagtgtgtgt gggaaagcat tcagccagag tgtgcacctt actcaacatc   1920
 agaggattca taatggagaa aaacccttta aatgcaatat atgtgggaaa gcatatagac   1980
 aaggcgcaaa tcttactcag catcaaagga ttcatactgg agaaaaaccc tataaatgta   2040
 atgaatgtgg gaaagctttc atttattcct catcacttaa tcaacatcag agaactcata   2100
 ctggagagag accctataaa tgtaatgaat gtgataagga ttttagccag agaacatgcc   2160
 ttattcaaca ccagagaatt cacacaggag agaaacccta tgcatgtcgt atatgtggta   2220
 aaaccttcac ccagagtaca aaccttattc agcatcaacg tgttcataca gaaagaaacc   2280
 ctgtgaaggg tattcaaaaa cataactcat caactctcta tttcaagtac acttatcctt   2340
 tggtatactc gggggattgg ttccaggacc acccatgtat acgaaaatct acccatactc   2400
 aagttgcacg                                                          2410



      <210> 1290
      <211> 539
      <212> DNA
      <213> Homo sapiens


      <400> 1290
 tggagatgga ggggccgagc ctgaggggtc ctgcgctccg cctggcgggg cttcccaccc     60
 aagcaggact gcaacattca agaaaaaata gacttagaaa ttcgaatgcg agaaggaata    120
 tggaaactcc tttctctgag cactcagaaa gatcaagttt tacatgcagt taagaatctc    180
 atggggtgca atgctcgact aatggcctat acatcggagc tacagaaatt agaagaacag    240
 attgcaaatc acactggaag atgtgatgtg aaatttgaaa gtaaagaacg aacagcatgt    300
 aaaggaaaga ttgccatatc agatattcga ataccactaa tgtggaaaga ctctgatcac    360
 ttcagcaata aagaacgatc acgacgctat gccatttttt gtttattcaa aatgggagct    420
 aatgtgtttg atactgatgt ggtgaatgtg gataaaacaa tcacagatat atgttttgaa    480
 aatgtaacca tattgtaagt attttttaat cttcagagaa taaaaataat ttaaaattc     539



      <210> 1291
      <211> 700
      <212> DNA
      <213> Homo sapiens


      <400> 1291
 gcggccgctg caggtgaagg tggtggggct cttcagctgc cccaactttc agattgcgaa     60
 gagcgccgct gagaatctga agaataatca tccatccaaa tttgaagatc ctatattagt    120
 tcctcttcaa gaatttgcat ggcatcaata tctacaggag aaaaaaaggg aactcaaaaa    180
 tgaaacctgg ggaatattct tcctctgtga tttcttttgt taatggtcag tttctgggtg    240
 atgcattgga tctgcagaaa tgggcccacg aggtgtggga tatagttgac attaaaccct    300
 ctgcacttta tgacgcactc actgaggatt tttccgctaa gttcttaaga gacaccaagc    360
 atgatttcgt gtttttggac atttgtattg attcttctcc aattggaaga ttgatttttg    420
 agctatactg tgatgtgtgt cccaaaacat gtaaaaattt tcaggtcttg tgcacaggaa    480
 aagcagggtt ttctcaacgt ggcataagac tacattacaa aaattccatt tttcatcgaa    540
 tagtacagaa tggctggata caaggagggg atatagtgta tggaaaagga gataatggag    600
 agtcgattta tggtccaaca tttgaagatg aaaacttttc agttcctcat aataaaagag    660
 gagtacttgg aatggccaac aaaggccgtc acagcagcgg                          700



      <210> 1292
      <211> 997
      <212> DNA
      <213> Homo sapiens


      <400> 1292
 gcgccggggc tgaaggcctg gtctctgtct aggtccatat gggttccagt tctggctttt     60
 gttccgagac acccctccgc acatttgaaa tcaaagggtc agcaggaaaa gatctgaaat    120
 gtgcagagac ttttgtgcct tcactacctc ttcttttgaa ctgtagcgga ccagagcatt    180
 tccgtgaggg aggttcaggt ggaatgtgat cagcgggccg tgctgcatgc acagagtgcg    240
 cagagttgag ccatcgatct gaggtgtaag gttttttaga acaagccaat ttgttattct    300
 ccctgagctg ctctcacccc agctggaacc tggggtatat ctggcgtcag aatttcccca    360
 tcctccacct atacgaaggg gagaattatc ccacgtagac aagggtggct tctgaccagt    420
 cagtcccgga ggtgggcggg acggagcagt gatgttttta ggtggcaaag ggaccttcca    480
 cagctcatga gccagagagg tgtttgtaac tgaaccagga gaccatgtca atttggaatc    540
 actatttctg gctgaagtgc tttgtgctgt actgctgagg ggaacgttgt agttggaggc    600
 acgaatggat gaccaggcac tagttgaagg cagcgtggtg ttcaaggatg aggatgaccc    660
 actgttcctg tccctgaggt ggtcaacttc ccgcacagta ttaattgaaa gattgtttat    720
 gacactgcca ggagtgacgt aagggtcagt ttcagggtca atgtttggat aacctttcca    780
 tggctcacca ggacgaaatt ttgcccaaga cttcatgctt aacttttcct caatcacttc    840
 tgcattcctt ctcatccgca cacgtcagtc taagcacgcc gatctgggct acatcagtag    900
 taagtccaga tgtaacaaaa ccatgtttgc tggagttttg atccaaagat gtgttcacag    960
 aaatgctgtc cactgtcgtc cacttcctta gtcttga                             997



      <210> 1293
      <211> 997
      <212> DNA
      <213> Homo sapiens


      <400> 1293
 gcgccggggc tgaaggcctg gtctctgtct aggtccatat gggttccagt tctggctttt     60
 gttccgagac acccctccgc acatttgaaa tcaaagggtc agcaggaaaa gatctgaaat    120
 gtgcagagac ttttgtgcct tcactacctc ttcttttgaa ctgtagcgga ccagagcatt    180
 tccgtgaggg aggttcaggt ggaatgtgat cagcgggccg tgctgcatgc acagagtgcg    240
 cagagttgag ccatcgatct gaggtgtaag gttttttaga acaagccaat ttgttattct    300
 ccctgagctg ctctcacccc agctggaacc tggggtatat ctggcgtcag aatttcccca    360
 tcctccacct atacgaaggg gagaattatc ccacgtagac aagggtggct tctgaccagt    420
 cagtcccgga ggtgggcggg acggagcagt gatgttttta ggtggcaaag ggaccttcca    480
 cagctcatga gccagagagg tgtttgtaac tgaaccagga gaccatgtca atttggaatc    540
 actatttctg gctgaagtgc tttgtgctgt actgctgagg ggaacgttgt agttggaggc    600
 acgaatggat gaccaggcac tagttgaagg cagcgtggtg ttcaaggatg aggatgaccc    660
 actgttcctg tccctgaggt ggtcaacttc ccgcacagta ttaattgaaa gattgtttat    720
 gacactgcca ggagtgacgt aagggtcagt ttcagggtca atgtttggat aacctttcca    780
 tggctcacca ggacgaaatt ttgcccaaga cttcatgctt aacttttcct caatcacttc    840
 tgcattcctt ctcatccgca cacgtcagtc taagcacgcc gatctgggct acatcagtag    900
 taagtccaga tgtaacaaaa ccatgtttgc tggagttttg atccaaagat gtgttcacag    960
 aaatgctgtc cactgtcgtc cacttcctta gtcttga                             997



      <210> 1294
      <211> 997
      <212> DNA
      <213> Homo sapiens


      <400> 1294
 gcgccggggc tgaaggcctg gtctctgtct aggtccatat gggttccagt tctggctttt     60
 gttccgagac acccctccgc acatttgaaa tcaaagggtc agcaggaaaa gatctgaaat    120
 gtgcagagac ttttgtgcct tcactacctc ttcttttgaa ctgtagcgga ccagagcatt    180
 tccgtgaggg aggttcaggt ggaatgtgat cagcgggccg tgctgcatgc acagagtgcg    240
 cagagttgag ccatcgatct gaggtgtaag gttttttaga acaagccaat ttgttattct    300
 ccctgagctg ctctcacccc agctggaacc tggggtatat ctggcgtcag aatttcccca    360
 tcctccacct atacgaaggg gagaattatc ccacgtagac aagggtggct tctgaccagt    420
 cagtcccgga ggtgggcggg acggagcagt gatgttttta ggtggcaaag ggaccttcca    480
 cagctcatga gccagagagg tgtttgtaac tgaaccagga gaccatgtca atttggaatc    540
 actatttctg gctgaagtgc tttgtgctgt actgctgagg ggaacgttgt agttggaggc    600
 acgaatggat gaccaggcac tagttgaagg cagcgtggtg ttcaaggatg aggatgaccc    660
 actgttcctg tccctgaggt ggtcaacttc ccgcacagta ttaattgaaa gattgtttat    720
 gacactgcca ggagtgacgt aagggtcagt ttcagggtca atgtttggat aacctttcca    780
 tggctcacca ggacgaaatt ttgcccaaga cttcatgctt aacttttcct caatcacttc    840
 tgcattcctt ctcatccgca cacgtcagtc taagcacgcc gatctgggct acatcagtag    900
 taagtccaga tgtaacaaaa ccatgtttgc tggagttttg atccaaagat gtgttcacag    960
 aaatgctgtc cactgtcgtc cacttcctta gtcttga                             997



      <210> 1295
      <211> 1050
      <212> DNA
      <213> Homo sapiens


      <400> 1295
 tttcgtgtcg ggatggaagc ttcctggcgc cgggtggccg gtggccgagg ccgatcccgg     60
 ggacgggcca ctgccgcccc ctcaggaaat ggagtccatc tccgcggcgc cggaggaggg    120
 cgagagaagg ggtcggtggg cgcagttcct tctggcacca gtcccggagg agtcgcgacc    180
 acggcggctg cagggagcag gcacagcccc gcaggatccc aagccctgca gactaccgca    240
 gccagcgagc taatgtctca gaaaaaattt gaagaaatca agaaagctaa ccaagctgca    300
 gccagaaaac ttgttgaaga acagtttagc tcttcatctg aagaaggaga tgaagatttt    360
 gaaggaaaac agggaaaaat acttgcaaat acgtttataa catacactgc tcagacaggc    420
 tcgtcggggg acccctcgga cgcggtctcc tgtacccact ttccaaccag tcccaacgag    480
 atgaaccagg tacctcactt ggaaatgcag aaatcacctg cagaaatcac atatctgcag    540
 aaatgcagaa gtcacatatc tgcagaaatg cagaagtcac atatctgcag aaatgcagaa    600
 gtcacatatc tgcagaaatg cagaagtcac atatctgcag aaatgcaaaa gtcacgtttc    660
 tgcagaaatg cagaagtcac atatctgcag aaatgcagaa gtcacgtttc tgcagaaatg    720
 cagaagtcac atatctgcag aaatgcagaa gtcacgtttc tgcagaaatg cagaagtcac    780
 gtttctgcag aaatgcagaa gtcacgtttc tgcagaaatg cagaagtcac gtttctgcag    840
 aaatgcagaa gtcacgtttc tgcagaaatg cagaagtcac gtatctgcag aaatgcagaa    900
 gtcacgtttc tgcagaaatg cagaaatcac ctgtcttctg tgttgatctc gctgggagct    960
 gtagaccaga gctgttccta ttcagcaact cccccatcaa aacaatttct tattcaacat   1020
 actagcagag ctaggattgc aaatgggtag                                    1050



      <210> 1296
      <211> 566
      <212> DNA
      <213> Homo sapiens


      <400> 1296
 gatttcgtct tccttggtca tatttttgga tgacaatcat ctgtttttgt gaggaggaat     60
 gggatgggca gtaagagtca gcttaaatcg ggctccgtga cagccaacgc agtgaccctc    120
 gccccttcct tggcagcaca tcatgcttgt gcagcggcag atgtctgtga tagaagagga    180
 cctggaagaa ttccagctcg ctctgaaaca ctacgtggag agtgcttcct cccaaagtgg    240
 atgcttgcgt atttctatac agaagctttc aaatgaatct cgctacatga tctatgagtt    300
 ctgggagaat agtagtgtat ggaatagcca ccttcagaca aattatagca agacattcca    360
 aagaagtaat gtggatttct tggaaactcc agaactcaca tctacaatgc tagttcctgc    420
 ttcgtggtgg atcctgaaca actagatgtt cctagacatt ttctttatgg ttccaagtgc    480
 aaaacaggtg ttcttatcta aaacgtcaat tagaaaatta tctgcggttg ttaatctact    540
 gtatattttt gtttggtata tttact                                         566



      <210> 1297
      <211> 401
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(401)
      <223> n = a,t,c or g


      <400> 1297
 gggtcgaccc acgcgtccga ccgtatcggc gacaaaccta tgatttatca gactcgntgn     60
 cttggntggg cccgtgggag tagggctgaa tgaactgaaa cgaaagctgc tgatcagtga    120
 cacccagcac tatggcgtga cagtgcccca taccaccaga gcaagaagaa gccaggagag    180
 tgatggtgtt gaatacattt tcatttccaa gcatttgttt gagacagatg tacaaaataa    240
 caagtttatt gaatatggag aatataaaaa caactactac ggcacaagta tagactcagt    300
 tcggtctgtc cttgctaaaa acaaagtttg gttgttggat gttcagcctc atacagtgaa    360
 gcatttaagg acactagaat ttaagcccta tgtgatattt a                        401



      <210> 1298
      <211> 356
      <212> DNA
      <213> Homo sapiens


      <400> 1298
 agaagaagtt ttaaaattag ggagagagtt ctgcctgaga gatttcaagc tttttctgct     60
 ttatttaaat tatgacttaa aggatcaggc agggaaaata ggctatggga acattttcta    120
 ttaattgacg aaaaactaga tatggggtaa agtagaaaaa ttgtttgtgt tctttgcagt    180
 acctccaaat ggtctggttg tatactgtgg aacaattgta acagaagaag gaaaggaaaa    240
 gaaagtcaac attgactttg aacctttcaa accaattaat acgtcattgt atttgtgtga    300
 caacaaattc catacagagg taagaagtca aacccagaac attttcatcg ctccag        356



      <210> 1299
      <211> 711
      <212> DNA
      <213> Homo sapiens


      <400> 1299
 atgccgaaag gaaaggaggc caaggggaag aagttggctc tggcccctgc ttttgtgaag     60
 aagcaggagg ccaagaaagt ggtgaatccc ctgtttgaga aaaggcctaa gaattttggc    120
 attggacagg acatccagcc caaaagagac ctcacctgct ttgtgaaatg gccccgctat    180
 atcaggttgc aatggcagag atccatactc tataagcagc tgaaaaccag agacaaagca    240
 agagaagaag tggaggctgt tggcccaggc agagttgtgg gcaaagggga cctccccatg    300
 aagagactac ctgtctttcg agcaggagtt aacaccgtca ccacctttgt ggataacaag    360
 aaagctccgc tggtggtgac tacacacgac atggatccca ttgagctgac tgttttcctg    420
 cctgtcctgt gtcataaaat gggggccact tgctgcatta tcaaggggaa ggcaagactg    480
 ggatgtctag ttcacaggaa gacctacacc actgtcgact tcacacaggt taactcagaa    540
 gacaaaggag ctttggctaa gctggtggaa gctatcggga ccaattacaa tgccagatac    600
 gatgagaccc actgtcactg ggacggcaat gtcctgggtc ccaagtctgt ggctcacatt    660
 gccaagctcg aaaaggcaaa ggctaaagaa cttgccacta aactgggtta a             711



      <210> 1300
      <211> 2323
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2323)
      <223> n = a,t,c or g


      <400> 1300
 ggaattcctc acctctcgtc cagggacatg acgggcacgc caggcgccgt tgccacccgg     60
 gatggcgagg cccccgagcg ctccccgccc tgcagtccga gctacgacct cacgggcaag    120
 gtgatgcttc tgggagacac aggcgtcggc aaaacatgtt tcctgatcca attcaaagac    180
 ggggccttcc tgtccggaac cttcatagcc accgtcggca tagacttcag gaacaaggtg    240
 gtgactgtgg atggcgtgag agtgaagctg cagatctggg acaccgctgg gcaggaacgg    300
 ttccgaagcg tcacccatgc ttattacaga gatgctcagg ccttgcttct gctgtatgac    360
 atcaccaaca aatcttcttt cgacaacatc agggcctggc tcactgagat tcatgagtat    420
 gcccagaggg acgtggtgat catgctgcta ggcaacaagg cggatatgag cagcgaaaga    480
 gtgatccgtt ccgaagacgg agagaccttg gccagggagt acggtgttcc cttcctggag    540
 accagcgcca agactggcat gaatgtggag ttagcctttc tggccatcgc caaggaactg    600
 aaataccggg ccgggcatca ggcggatgag cccagcttcc agatccgaga ctatgtagag    660
 tcccagaaga agcgctccag ctgctgctcc ttcatgtgaa tcccaggggg cagagaggag    720
 gctctggagg cacacaggat gcagccttcc ccctcccagg cctggcttat tccaagaggc    780
 tgagccaatg gggagaaaga tggaggactc actgcacagc cgcttcctag cagggagcta    840
 tactccaact cctacttgag ttcctgcggt ctccccgcat ccacagggag ggtaaaacac    900
 ttagctttta ttttaatagt acataattta ataccaaaaa aggcgcctgg atccccaaaa    960
 aaccgaggct gggagctagt ggcccttttg ctttctagga cttggggggc cggccctccc   1020
 tcctaagcat aacaaaggtg gtgttgctcc agctcagccc caggggacac agatgcactt   1080
 tgggggtgag ggcaggtaat gactccatcg caccctcagt tcagctggac agaggctcag   1140
 gtgaccccag ccttcactgt ctcccgctct ccaggagctt atcttcgccc catctcccaa   1200
 ataagtgggc ccttgtgctg tgaggaagac caaagcctca gggaagataa gagatatgga   1260
 gatgggaggg ggaggacaag gggcagagag tagggtctag ctggctatct ctggccttac   1320
 taacaccccc ctggaggcat gccccttttc tccagcacac aagcacattg gggcacctgg   1380
 aaatattggt tccaggctcc tgttctctgg acttcagatc ctgggggagc ccctcccccc   1440
 cctgaatccc tggcttagct accttcctgc ctgtgcacct aaaaacctca ggtcagaact   1500
 aggaaaagag ttttgttttt atttttttga aatggagtct cgttctgtcg cccaggctga   1560
 ggtgcagtag tgcaatctcc gctcactaca acctccactc cctggggctc aagcgatcct   1620
 cccacctcag cccccgaagt agctgggact ataggtgtgt accatcacac ctggctaatt   1680
 tttgtatttt ttgtagacac agggtttcgc catgttgccc aggctggtct tgaattcctg   1740
 agctcaagca acctgccggc ctcggcctcc caaagtactg ggattacacg cagaaggcac   1800
 catgcccagg ctagatgtgt cttatcccaa tcctttggca ggcatgcagc tccacaggcg   1860
 atttcttcaa gcagctgaag tgtttagccc tcctgggtta agagccagat aaggagaaat   1920
 ccctttccta ggtttggaat gtgttgtgaa aaaaaagaga aatccctggc tcctggagct   1980
 ggtgggagac aagattaagc aaacctcccc tgacatgtat ccctttgacc ccaagctctg   2040
 cctcctccct gaccacccat gccctttcct ttaacttctc aaacagatac cagggcctaa   2100
 actgctttac ctcccctcct actgagtcag gttaggtggt ggggaggttc aacccatttc   2160
 cgagtttaaa cccaatgcaa tattgagtaa aacaaagttc atgtggggta ttgtctgggg   2220
 tagagagagg ggtagcaagt tcatgtgtcc tccttggtca catatctccc aaagctctga   2280
 tccctnccat gggaagtgga caggaaacat gaggtcatga cct                     2323



      <210> 1301
      <211> 584
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(584)
      <223> n = a,t,c or g


      <400> 1301
 agcggccgcc agcgccagct ggtagtaccc ggctgcatca aacgggtcct tcaggtcgta     60
 gaagatgatg tcaccgagca ccaggtacac cttcacgtag tagaggggtc tcctcgtcaa    120
 actccagcgg cgagttgcag agcgacaggg ccttgaggta gaagtgctct gccagctcgc    180
 catggcccag tccggtgttg cagggcggcc agccgggtgg taggccacgc gctcgttcag    240
 ccggtccccc agggtgatgc tgagtgctag ggccatgtgg gcaaactcca agccctcctg    300
 gggctcctcc cagcgtggcc aagcagtgcc accagcttgt tgcacagccg cagctccgcc    360
 ttgcgtatgc ccgtagtcac tgccaagggc atgggcccgg tcccggtaga aggacacagc    420
 tttctcccgc tcccaggccc cgtcgaagaa gatgtctcca gccgcctcaa acagctccag    480
 ccccaggttg gggtcgcctg tgtacagggc cacgttctgt gccacctgga tgtagaggtc    540
 caccatgctc ntctgccgca agatgtaata gatcttccct gctt                     584



      <210> 1302
      <211> 1825
      <212> DNA
      <213> Homo sapiens


      <400> 1302
 atgagactgg gatttgaatc aaggggtgag atagcaaaag atcaagctaa acttgatcta     60
 gcagggcaaa aagaaaggga taaccaaagc tcaacattgg gggaagcaga aaccccattg    120
 attatttgct ggtcgactct agaggatccc cactatgatg tcatagttat tgacagcgcg    180
 cctaacctgg gtatcggcac gattaatgtc gtatgtgctg ctgatgtgct gattgttccc    240
 acgcctgctg agttgtttga ctacacctcc gcactgcagt ttttcgatat gcttcgtgat    300
 ctgctcaaga acgttgatct taaagggttc gagcctgatg tacgtatttt gcttaccaaa    360
 tacagcaata gtaatggctc tcagtccccg tggatggagg agcaaattcg ggatgcctgg    420
 ggaagcatgg ttctaaaaaa tgttgtacgt gaaacggatg aagttggtaa aggtcagatc    480
 cggatgagaa cctgtttttg aacaggccat tgatcaacgc tcttcaactg atacttcgtt    540
 atcgacacca gctgccccga tggtggattc gttaattgcg cgcgtaggag taatggctcg    600
 cggtaatgcc attactttgc ctgtatgtgg tcgggatgtg aagtttactc ttgaagtgct    660
 ccggggtgat agtgttgaga agacctctcg ggtatggtca ggtaatgaac gtgaccagga    720
 gctgcttact gaggacgcac tggatgatct catcccttct tttctactga ctggtcaaca    780
 gacaccggcg ttcggtcgaa gagtttcctt gtaccctctg gcaggaggag cgactcaagc    840
 cttcgcgaaa gaaaataacc aaaaagcata caaagaaacg tacggcgtct ctcatattac    900
 acgccatgat atgctgcaga tccctaaaca gcagcaaaac gaaaaatacc aagtgcctca    960
 attcgatcaa tcaacgatta aaaatattga gtctgcaaaa ggacttgatg tgtgggacag   1020
 ctggccgctg caaaacgctg acggaacagt agctgaatac aacggctatc acgttgtgtt   1080
 tgctcttgcg ggaagcccga aagacgctga tgacacatca atctacatgt tttatcaaaa   1140
 ggtcggcgac aactcaatcg acagctggaa aaacgcgggc cgtgtcttta aagacagcga   1200
 taagttcgac gccaacgatc cgatcctgaa agatcagacg caagaatggt ccggttctgc   1260
 aacctttaca tctgacggaa aaatccgttt attctacact gactattccg gtaaacatta   1320
 cggcaaacaa agcctgacaa cagcgcaggt aaatgtgtca aaatctgatg acacactcaa   1380
 aatcaacgga gtggaagatc acaaaacgat ttttgacgga gacggaaaaa catatcagaa   1440
 cgttcagcag tttatcgatg aaggcaatta tacatccggc gacaaccata cgctgagaga   1500
 ccctcactac gttgaagaca aaggccataa ataccttgta ttcgaagcca acacgggaac   1560
 agaaaacgga taccaaggcg aagaatcttt atttaacaaa gcgtactacg gcggcggcac   1620
 gaacttcttc ccatgccgcg gccgcctcgc ggctacccgg cttgccggtc ccgagcggca   1680
 gccccggggt ggcgatgggg tcgcgccgag gcagcggagg ttctgcgggc gactggaggt   1740
 tggcagtggg cgggagaaag aggaaggcaa gcgcggctgg gcctcggcct ctggcgccgc   1800
 ggtacccttt gtctcggcag cctga                                         1825



      <210> 1303
      <211> 1874
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1874)
      <223> n = a,t,c or g


      <400> 1303
 accatgcnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn aggattcaca atttgaacaa     60
 attctatttt aagcttcata ttttcctcag catttnnnnn nnnnncacgt acagagacca    120
 tgtccagggc agcagctgca gccggacccc cacgccaggc cacccctgcc tctccccggt    180
 ggtccaatga ctgtgtactg cgcagggaat gcagcaaccc catcgggcac actcttcagc    240
 actacccggg gaggtaccag gatcatgtac aactggaaat tcccaataga gtgctgaact    300
 caccagtgac caaaacaccc tcgagggacc cgcccaccac ttccggggtc accagccctg    360
 ccagtgatga gcccccggca gacatacaga cagcccagaa cagcaggcag gtggtgaagg    420
 gtcagagttt gacctggaca tctaaaggcc tagccatgag aaggaaagga agcagagacc    480
 tggtggttga cagtgccaag tccctggaag atggcccatc tgcagcactt cactcgaaac    540
 tctatgaagc catcatgaga gaagactgca ctacgatcga ggtactcctg agaaatcacc    600
 ctgtcaacca gcccatcacc attctgccca actccgccag caacagatta cttctgaccc    660
 agccgacaga gtctatcatc cccatccatc tggctgccaa gtaccacaag gcccagagtc    720
 tgctctgcct gttacggcac ggtgctgacc cagaagtcag ggacacgaca ggcctcacca    780
 cactcaactt aatgctactg cactggccag tcacttccac cacgtgggca aaaccaggca    840
 acagaacgca caggatcctg acagacattc agaatagcag catcacatgt ctccgcatct    900
 tgtgtgcgca cggagctcaa gtgaacactc aaggggaaat cagcaacaaa cgttcaccac    960
 tccacctggc catagcatat ggttgctatc cagttctctc cattttgacc caaaatggtg   1020
 ccgatgtcaa tgctattaat gaagccagca tgacacccct tcacatggcc gcaaacatgc   1080
 tgaataagga gatgatggaa acgctcattg cctatggagc aaacgtcaac tgtgctgtct   1140
 cttccacggg gaacacgccc ctgaagcttg cagtgtgcac tgcatcaagc aaagcaggcc   1200
 gactcctcgg ggcgggggtc agctgcatcc gtctgctact cactcacgga gccaaagtca   1260
 acgcccagga ctacaagggc caaacagcca tccatgaggc atgctttgga ggcagagagg   1320
 caatcatcaa tctcctgctt gaatttgaag caaatgttaa cattttaaca agaaacgggg   1380
 aatctccaat ttatatgtac cttcagcgca gttgcaatgt aagagatacg gcacttctgg   1440
 ccaggctact ttatcacact tatcctctga gaatgaccaa taaccaagga attctacctg   1500
 caggaatcat gctaccagaa ttccgcctct taagggacac cctaataaag caatcgcaaa   1560
 aacctttatc cctacagggt atctgccaaa gaaacatcag gaatatttat ggtgagaaat   1620
 acaagcagcc cttgaagcaa ttcctcccag tgacaatatg gaattctgtc tactgctggt   1680
 atgacttggc atatacctct tgaaataaga cctcccagtt tcacagcaga gggactttcg   1740
 gccactccaa ctgcattttc tggctagaca tggcccagaa aatgcttccc ctatcacctg   1800
 tgacatccca aatgtgccaa ctactgattc ttgaacatgt tccaaaaaac aaagtgattt   1860
 gtctattaaa aaaa                                                     1874



      <210> 1304
      <211> 1839
      <212> DNA
      <213> Homo sapiens


      <400> 1304
 atggaacgct gtggtatcga accgcagttg cagggtcgac ccacgcgtcc gcggacgcgt     60
 gggggggtgc ggaggtgtgc agcgcgctgt cagactggct cgcaggcggc gcggccggcg    120
 gacccgttcg agacagcgcg ggcggctcgg gtcccctggg gctccgcagc aggaggacgc    180
 catggacgac aaggagttaa ttgaatactt taagtctcag atgaaagaag atcctgacat    240
 ggcctcagca gtggctgcca tccggacgtt gctggagttc ttgaagagag ataaagggga    300
 gacaatccag ggtctgaggg cgaatctcac cagtgccata gaaaccctgt gtggtgtgga    360
 ctcctctgtg gcagtgtcct ctggcgggga gctcttcctc cgcttcatca gtcttgcctc    420
 cctggaatac tccgattact ccaaatgtaa aaagatcatg attgagcggg gagaactttt    480
 tctcaggaga atatcactgt caagaaacaa aattgcagat ctgtgccata ctttcatcaa    540
 agatggagcg acaatattga ctcacgccta ctccagagtg gtcctgagag tcctggaagc    600
 agccgtggcg gccaagaagc gatttagtgt atacgtcaca gagtcacagc ctgatttgtc    660
 aggtaagaaa atggccaaag ccctctgcca cctcaacgtc cctgtcactg tggtgctaga    720
 tgctgctgtc ggctacatca tggagaaagc agatcttgtc atagttggtg ctgaaggagt    780
 tgttgaaaac ggaggaatta ttaacaagat tggaaccaac cagatggctg tgtgtgccaa    840
 agcacagaac aaacctttct atgtggttgc agaaagtttc aagtttgtcc ggctctttcc    900
 actaaaccag caagacgtcc cagataagtt taagtataag gcagacactc tcaaggtcgc    960
 gcagactgga caagacctca aagaggagca tccgtgggtc gactacactg ccccttcctt   1020
 aatcactctg ctgtttacag acctgggcgt gctgacaccc tcagcagtca gcgatgagct   1080
 catcaagctc tatctgtaac ctgtgagccc tttcctgcca aggtgcagct tacgtagttg   1140
 aggcagggtg agtagctgct tgacacccca gtgagtcagg ccaaaactga gatgtgttta   1200
 atgaagattt atggagtaag gacttaaaat catacatctt ggagaacctt tcttactcat   1260
 ttcagtccca tctaaaaatg tgtcagctat tctaaatccc aacttaaatt gttcttacgg   1320
 tttctagaaa ctttcctttt cagtttccag aaatacaagt tagataattg gctacttaac   1380
 tgatgaaaga tgagcccaag tccacctgtc ttcatcctcc cctgcactcc agactgatct   1440
 gcctaaagca cgcgagatgc aggcgaaaag cagccacacc cctctgccac aaatgaccaa   1500
 cagctggtca ggacgttaca cgcggtgcct tgtaagaggc aagaaacact tgccgaatct   1560
 gcatctggct tccagtggta agcacattcc tcagcaggat caagccaaac agtaaaaact   1620
 accaagagaa cacgaggaag gcagaaacga tgtttagcaa cagtattctg catggttcac   1680
 tgcttaagaa aatgccttct ggaatatttg taaactgaaa ttctgtatgt gtaagagatg   1740
 tttaaatatg tttgggtcct aaacagcttt ttaaaattat acttgggaat aaattcagca   1800
 tcttttcaaa taaactctat gaaagacgca aaaaaaaaa                          1839



      <210> 1305
      <211> 2253
      <212> DNA
      <213> Homo sapiens


      <400> 1305
 atgcagcgga gccccccgac ttgccgacaa gcgcagacca gtctagaagt ggccctgtac     60
 atgtttctgc agaaccctga cactgaagct gttctggttg ccatgtcctg tttctgccac    120
 ctctgtgagg aagcagatac ccagtgtggg gtggatgaag tgtcagtgca taacctcttg    180
 cccaactcta acacattcat ggagtttgcc tgtcagcaat gtgatgtcaa cagcccaccc    240
 gtgggtccgg tcagtgaaca taagggttcc atgatttcag tgatgtcctc agagggaaac    300
 gcagatacac ctgtcagcaa atatatggat cagctcttgt cgttaatggt gtgtaacctt    360
 gagaaagtgg gacttcaaat accgaccaat gataaggacc tggttttatt gactgatacc    420
 aatactcaat ttgtagagca aaccctagat ataatgaaga acttgctaga taatcatact    480
 gaaggcagcc ctgaacatct agagcaagct agcattgaaa caatgatgtt aaatctggtc    540
 aggaataaga tggtggaata cctgacagac tgggttatgg gaacatcaaa ccaagcagca    600
 gatgatgatg taaaatgtct tacaagccgc atcaccatcc tggtggaact ctcctgtgag    660
 gacagccaag gcctgaacta cctgcgggtt tgcccaggca accagccagc cctggtccaa    720
 ggcatcctgg agcgagttgt ggatggcccc gtgccccacc agacagtgcg cctggaggac    780
 ctggacgaga gcggtgagcc ccaggctggg gagccagtgc tgcctggcat cctccggcca    840
 ccctacctgg ctgaggggct gggcctgggc ctgccggtcc ctggagctcc cggtccctgg    900
 agctctgcac ttgggggcac aacttgcatg aggcagcgcg actctggcga ctggctggcc    960
 atgccgtccc gggctgagaa ctatgaagtg ttgtacacca ttggcacagg ctcctgtggc   1020
 cgctgccaga agatccagag gaagagtgac ggcaagatac tagtttggaa agaacttcat   1080
 tatggctcca tgacagaagc tgagaaacag atgcttgttt ctgaagtgaa tttgctttgt   1140
 gaactgaaaa atccaaacat cgttcattac tatgatcgta ttattgaccg gaccaacaca   1200
 acactgtaca ttgtaatgga atattgtgaa gaaggagacc tggctagtgt aattacaaag   1260
 ggaaccaagg aaaggcaata cttagatgaa gagtttgttc ttcgagtgac gactcagttg   1320
 actctggccc tgaaacgaag tgatggtgat catactgtag tgcgtcggga tctgaaacca   1380
 gccagtgttt tcctggatgg caagcaaaac gtcaagcttg gagatttggg gctagccaga   1440
 atattaaacc acgacacgag ttttgcaaaa acatttgttg gcacacctta ttacatgtct   1500
 cctgaacaaa cgaatcacat gtcctacaat gagaaaccag atatctggtc attgggccgt   1560
 ttgctgtatg agttaggtgc attaatgcct ccatttacag cttttagcca gaaagaactt   1620
 gctgggaaaa tcagagaagg caaattcagg caaattctat accgtgactc tgacgaattg   1680
 aatgaaatta ttatgaggat gttaaaggat taccatcgac cttctgttga agaaattctc   1740
 gagaaccctt taatagcaga tttggttgca gaagaacgaa gaagaaatct tgagagaaga   1800
 gggcgacaat taggagagcc agaaaaattg caggattcca gccctgtatt gagtgagctg   1860
 aaactaaagg aaattcagtt agaggagcga gagcgagctc tcaaagcaag agaagaaaga   1920
 ttggagcaga aagaacagga gttttgtgtc cgtgagagac tagcagagga cagactggct   1980
 agagcagaaa atctgttgaa gaattacagc ttgctaaaga agttcctgtc tctggcaagt   2040
 agtccagaac ttcttagtct tccatcctca gtaattaaga agaaaggtca tttcagtggg   2100
 gaaagtaaag agaatgtcat gaggagtgag aattctgaga gtcagctcac atctaagtcc   2160
 aagtgcaagg acctgaaggt ccttgcttca tgcttcatgc tgcccagctg cgggctcaag   2220
 ccctgtcaga tattgagaaa aattatcaac taa                                2253



      <210> 1306
      <211> 952
      <212> DNA
      <213> Homo sapiens


      <400> 1306
 ggaccgaggg ccaaaagaat cttattgtgg aagtgacttc caatgatgct gtgagatttt     60
 atccctggac cattgataat aaatactatt cagcagacat caatctatgt gtggtgccaa    120
 acaaatttct tgttactgca gagattgcag aatctgtcca agcatttgtg gtttactttg    180
 acagcacaca aaaatcgggc cttgatagtg tctcctcatg gcttccactg gcaaaagcat    240
 ggttacctga ggtgatgatc ttggtctgcg atagagtgtc tgaagatggt ataaaccgac    300
 aaaaagctca agaatggtgc atcaaacatg gctttgaatt ggtagaactt agtccagagg    360
 agttgcctga ggaggatgat gacttcccag aatctacagg agtaaagcga attgtccaag    420
 ccctgaatgc caatgtgtgg tccaatgtag tgatgaagaa tgataggaac caaggcttta    480
 gccttctcaa ctcattgact ggaacaaacc atagcattgg gtcagcagat ccctgtcacc    540
 cagagcaacc ccatttgcca gcagcagata gtactgaatc cctctctgat catcggggtg    600
 gtgcatctaa cacaacagat gcccaggttg atagcattgt ggatcccatg ttagatctgg    660
 atattcaaga attagccagt cttaccactg gaggaggaga tgtggagaat tttgaaaggc    720
 tctttttcaa agttaaagga aatgagagac aaggctgcga cgcttcctca tgagcaaaga    780
 aaagtgcatg cagaaaaggt ggccaaagca ttctggatgg caatcggggg agacagagat    840
 gaaattgaag gcctttcatc tgatgaagag cactgaatta ttcatactag ggtttgacca    900
 acaaagatgc tagctgtctc tgagatacct ctctactcag cccagtcata tt            952



      <210> 1307
      <211> 379
      <212> DNA
      <213> Homo sapiens


      <400> 1307
 acttgaaaac tgtggacaag ttcaacgagt ggtttgtgtc ggcatttgtc actgcggggc     60
 atatccttac cttcttagta aaggtaacta actaaagttt gggctcacaa accagaagaa    120
 catggaacat agatgccagg ctctgagtct gtagacttca cagtcaggtg aaaatgtaag    180
 tttccattta tggggctact tttctttttt taggggggaa aaacattttg tttaatagct    240
 aattttaaaa ctaagtctca tacacaaaaa gagtttatct ggaccctatc aagggtgatt    300
 ttactttatt ttacagttat tttctaactt tgaaagctta tgttctcttt atgataaaac    360
 taagctaatt ttaaaccca                                                 379



      <210> 1308
      <211> 1582
      <212> DNA
      <213> Homo sapiens


      <400> 1308
 tcggaattcc cggcccgacg atttcgttgg ccggctccta ccctgaaggt gcacctgcag     60
 tcctcgccga taagaggcag cagttcggaa gccggttcct gagagatccg gcgcgcgtct    120
 tccaccacaa tgcctggtaa tcactctgcc ccttcgcccg gcctgtcgct gaccctctgt    180
 cccgccgcct cggagcactc cgaaaagccc ctgaccgccg gccacgagtc aagctgccct    240
 acccgaggca ctctccaagg ggagagaaac tcctaggcca gcgactcacc ctgcccgcag    300
 ccaggacgtg aggcccctaa gctgcccgtt tgattttctc agggacaatg tggagtggtc    360
 ggaagagcaa gccgcggcgg cggagagaaa agtccaggag aacagtatcc agcgggtgtg    420
 ccaggagaaa caagttgatt atgagatcaa tgcccacaaa tactggaatg acttctacaa    480
 aatccacgaa aatgggtttt tcaaggatag acattggctt tttaccgaat tccctgagct    540
 ggcacctagc caaaatcaaa atcatttgaa ggactggttc ttggagaaca agagtgaagt    600
 acctgaatgt agaaacaatg aggatggacc tggtttaata atggaagaac agcacaagtg    660
 ttcttcgaag agccttgaac ataaaacaca gacacctcct gtggaggaga atgtaactca    720
 gaaaattagt gacctggaaa tttgtgctga tgagtttcct ggatcctcag ccacctaccg    780
 aatactggag gttggctgtg gtgtgggaaa cacagtcttt ccaattttac aaacgaacaa    840
 tgacccagga ctctttgttt attgctgtga tttttcttcc acagctatag aactggtcca    900
 gacaaattca gaatatgatc cttctcggtg ttttgccttt gttcacgacc tgtgtgatga    960
 agagaagagt tacccagtgc ccaagggcag tcttgatatt atcattctca tatttgttct   1020
 ttcagcaatt gttccagaca agatgcagaa ggctatcaac aggctgagca ggcttctgaa   1080
 acctgggggg atggtacttc tgcgagatta cggccgctat gacatggctc agcttcggtt   1140
 taaaaaaggt cagtgtctat ctggaaattt ctatgtgaga ggtgatggaa ccagagttta   1200
 cttcttcaca caagaggaac tggacacgct tttcaccact gctggactgg aaaaagttca   1260
 gaacctggtg gaccgccgac tgcaggtgaa ccgagggaag caactgacaa tgtaccgggt   1320
 ttggattcag tgcaaatact gcaagcccct tctgtccagc accagctaag aggcacctgc   1380
 tgccaacacg atgcaagccc gttgtgtttc cgagcttttt taaaaaaaaa tttgtagcac   1440
 cgggcatggt gcatgcctgt aatcccagcc actcaggagg ctgagacagg gaggatccat   1500
 tgagcccagg agtccagcct gggcaaaata gcgagagacc ctgaatctga aagtaatgat   1560
 aaaataaaaa gaatataaat ga                                            1582



      <210> 1309
      <211> 405
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(405)
      <223> n = a,t,c or g


      <400> 1309
 tttcgtcggc ggtcctggtg cggaccctcc ggtcgcagtc atgtgggacc cgcgggcagc     60
 taggatggac ctgacagctt acgctgagct gctgaaagaa tccggcaacc aggttcttaa    120
 gaatgggaac ttctctttgg ccatcagaaa gtacgatgaa gccatccaga ttctcctgca    180
 gttataccag tggggggttc ccccgaggga cttggctgtg ctgctgtgca acaaatcaaa    240
 tgcatttttc agccttggga agtggaatga ggcatttgtt gctgccaagg aatgtctcca    300
 atgggatcca acctacgtga agggatacta ccgagctggt tattccttgc tgaggttgca    360
 ccagccttac gaagccgctc gcatgttttt tgagggtctg cgacn                    405



      <210> 1310
      <211> 2426
      <212> DNA
      <213> Homo sapiens


      <400> 1310
 tttcgtaact taaggtatat taagcagtcc ccacagacat gctgcctgca ctccacctgc     60
 tgagctggct ctgaggctca ggagacgtgg ccctctgtgg tcccattgtc tccacgtctg    120
 tggtaacccg gtgcctttct agagcaggca ggctcccggc atgggtggaa acagagcagg    180
 gggccagctt cccccaatca ccggtgctgc tgtggaggaa gagcttggtg gcgctaggac    240
 gtccttgtga atgtgacttg gaagagcagt ttgggatttt tttcattgcc tggggatgag    300
 agggagagac aacgtgtgtc ttacacatct cccaacagcc gacttagatg tgatccgttc    360
 tcccagaggg agcaggtttc tttgaacttt tcctttttat gtacagcata gtgctgagca    420
 gatcactgca ctgtgcagga gttttaacga cagtcaggcc aacggcatgg aaggaccgcg    480
 ggagaatcag gatcctcctc cgaggcctct ggcccgccac ctgtctgatg cagaccgcct    540
 ccgcaaagtc atccaggagc ttgtggacac agagaagtcc tacgtgaagg atttgagctg    600
 cctctttgaa ttatacttgg agccacttca gaatgagacc tttcttaccc aagatgagat    660
 ggagtcactt tttggaagtt tgccagagat gcttgagttt cagaaggtgt ttctggagac    720
 cctggaggat gggatttcag catcatctga ctttaacacc ctagaaaccc cctcacagtt    780
 tagaaaatta ctgttttccc ttggaggctc tttcctttat tacgcggacc actttaaact    840
 gtacagtgga ttctgtgcta accatatcaa agtacagaag gttctggagc gagctaaaac    900
 tgacaaagcc ttcaaggctt ttctggacgc ccggaacccc accaagcagc attcctccac    960
 gctggagtcc tacctcatca agccggttca gagagtgctc aagtacccgc tgctgctcaa   1020
 ggagctggtg tccctgacgg accaggagag cgaggagcac taccacctga cggaagcact   1080
 aaaggcaatg gagaaagtag cgagccacat caatgagatg cagaagatct atgaggatta   1140
 tgggaccgtg tttgaccagc tagtagctga gcagagcgga acagagaagg aggtaacaga   1200
 actttcgatg ggagagcttc tgatgcactc tacggtttcc tggttgaatc catttctgtc   1260
 tctaggaaaa gctagaaagg accttgagct cacagtattt gtttttaaga gagccgtcat   1320
 actggtttat aaagaaaact gcaaactgaa aaagaaattg ccctcgaatt cccggcctgc   1380
 acacaactct actgacttgg acccatttaa attccgctgg ttgatcccca tctccgcgct   1440
 tcaagtcaga ctggggaatc cagcagggac agaaaataat tccatatggg aactgatcca   1500
 tacgaagtca gaaatagaag gacggccaga aaccatcttt cagttgtgtt gcagtgacag   1560
 tgaaagcaaa accaacattg ttaaggtgat tcgttctatt ctgagggaga acttcaggcg   1620
 tcacataaag tgtgaattac cactggagaa aacgtgtaag gatcgcctgg tacctcttaa   1680
 gaaccgagtt cctgtttcgg ccaaattagc ttcatccagg tctttaaaag tcctgaagaa   1740
 ttcctccagc aacgagtgga ccggtgagac tggcaaggga accttgctgg actctgacga   1800
 gggcagcttg agcagcggca cccagagcag cggctgcccc acggctgagg gcaggcagga   1860
 ctccaagagc acttctcccg ggaaataccc acaccccggc ttggcagatt ttgctgacaa   1920
 tctcatcaaa gagagtgaca tcctgagcga tgaagatgat gaccaccgtc agactgtgaa   1980
 gcagggcagc cctactaaag acatcgaaat tcagttccag agactgagga tttccgagga   2040
 cccagacgtt caccccgagg ctgagcagca gcctggcccg gagtcgggtg agggtcagaa   2100
 aggaggagag cagcccaaac tggtccgggg gcacttctgc cccattaaac gaaaagccaa   2160
 cagcaccaag agggacagag gaactttgct caaggcgcag atccgtcacc agtcccttga   2220
 cagtcagtct gaaaatgcca ccatcgacct aaattctgtt ctagagcgag aattcagtgt   2280
 ccagagttta acatctgttg tcagtgagga gtgtttttat gaaacagaga gccacggaaa   2340
 atcatagtat gattcaatcc agatatgggt taaattcctc attttacttt taaactggtg   2400
 gtaaagtgga aattgcaaaa aaaaaa                                        2426



      <210> 1311
      <211> 1359
      <212> DNA
      <213> Homo sapiens


      <400> 1311
 atgcccccgc gcgcgccgcc ggcctcagtt tcccgggggc ggatgggcgg gcgggcgcgg     60
 cggcggcggc gggagatgtt cgcggtacgc ggccccggac ccgtggggga cgtcgagggg    120
 tctcggggcg ccgcgctcag ctccccggcc ccgcggccct ggacaccgct ccaggaccct    180
 ggcggctggg accccaggaa gaaaaccgtc taccggagtc tgtgcctggc cctggccctg    240
 ctcgtggccg tgacggtgtt ccaacgcagt ctcacccctg gtcagtttct gcaggagcct    300
 ccgccaccca ccctggagcc acagaaggcc cagaagccaa atggacagct ggtgaacccc    360
 aacaacttct ggaagaaccc gaaagatgtg gcccaggcct gggacgtgac caccactaac    420
 tgctcagcca atatcaactt gacccaccag ccctggttcc aggtcctgga gccgcagttc    480
 cggcagtttc tcttctaccg ccactgccgc tacttcccca tgctgctgaa ccacccggag    540
 aagtgcaggg gcgatgtcta cctgctggtg gttgtcaagt cggtcatcac gcagcacgac    600
 cgccgcgagg ccatccgcca gacctgggcg cgagcggcag tccgcgggtg ggggccgagc    660
 gccgtgcgca ccctcttcct gctgggcacg gcctccaagc aggaggagcg cacgcactac    720
 cagcagctgc tggcctacga agacgccctc tacggcgaca tcctgcagtg gggctttctc    780
 gacaccttct tcaacctgac cctcaaggag atccacttcc tcaagtggct ggacatctac    840
 tgcccccacg tccccttcat tttcaaaggc gacgatgacg tcttcgtcaa ccccaccaac    900
 ctgctagaat ttctggctga ccggcagcca caggaaaacc tgttcgtggg cgatgtcctg    960
 cagcacgctc ggcccattcg caggaaagac aacaaatact acatcccggg ggccctgtac   1020
 ggcaaggcca gctatccgcc gtatgcaggc ggcggtggct tcctcatggc cggcagcctg   1080
 gcccggcgcc tgcaccatgc ctgcgacacc ctggagctct acccgatcga cgacgtcttt   1140
 ctgggcatgt gcctggaggt gctgggcgtg cagcccacgg cccacgaggg cttcaagact   1200
 ttcggcatct cccggaaccg caacagccgc atgaacaagg agccgtgctt tttccgcgcc   1260
 atgctcgtgg tgcacaagct gctgccccct gagctgctcg ccatgtgggg gctggtgcac   1320
 agcaatctca cctgctcccg caagctccag gtgctctga                          1359



      <210> 1312
      <211> 388
      <212> DNA
      <213> Homo sapiens


      <400> 1312
 agctcccgga gtcagggact atgtctccct cgtcagactg ggaactccag gagggagggt     60
 ccgtgtctcc tccatcagac tgggagctcc cagagtcagg gaccatgttt cctccatcag    120
 actgggagct cccagagtca gggaccatgt ctcctccatc agactgggag ctcccagagt    180
 cagggtctat gtctcctcca tcagaccggg agctcccaga gtcagggacc atgtctcctt    240
 catcagactg ggagctccca gagtcaggga ccatgtctcc ttcatcagac tgggagctcc    300
 cagagtcagg gaccatgtct cctccatcag accgggagct cccagagtca gggtctatgt    360
 ctcctccatc agaccgggag ctcccagg                                       388



      <210> 1313
      <211> 437
      <212> DNA
      <213> Homo sapiens


      <400> 1313
 aggtaaacaa actgcaactt atatctgcaa tttattttgg tatagacaag aggtatgcca     60
 gtagcacact ggtggcttca gaagaaattc tcaacaccta gctcgccaga gagtctatgt    120
 atgggattga acaatctgta aactaaagga tcctaatcat gaaaataagt atgataaatt    180
 ataagtcact attggcactg ttgtttatat tagcctcctg gatcattttt acagttttcc    240
 agaactccac aaaggtttgg tctgctctaa acttatccat ctccctccat tactggaaca    300
 actccacaaa gtccttattc cctaaaacac cactgatatc attaaagcca ctaacagaga    360
 ctgaactcag aataaaggaa atcatagaga aactagatca gcagatccca cccagacctt    420
 tcacccacgt gaacacc                                                   437



      <210> 1314
      <211> 2210
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2210)
      <223> n = a,t,c or g


      <400> 1314
 tttttttttt ttctttaaag aaaacaagtt ttatttttat catcagaaca ttctaataaa     60
 aatattatga tgagattagc tacctttatt ctctgagcct tgactctgtc acaggcctgc    120
 cctgggngcg cctgcacgct cagctccctg aggtaggtcc ggaggggggg agaccccccc    180
 gctgcccccc gcccctnggg cagggatacc ctttaccttt aatggtcccc tccttccaga    240
 cccccaacag cccttgggat gccccattag cagccctgcc acgggttggg aagaaactgg    300
 cctccaccct ccaccaaccc ccaagacagg caaggaaacc gtctcagggc tgggcacaac    360
 agcaggtggt gcgggggtag agggaagagg cgcacccttc tgcactcaac cgctccagcg    420
 ggcagagctg agggccactg ccccccccag gctggcacca ccatggtcta gaccccaagt    480
 ggcctgaatg ctgtggatca cttccttctc cccttccaca gtgtttgggg agttggggag    540
 gaagggaagg gagaggagtg tcaacgtcgc agtgacgggg tcctgagaca actcactctg    600
 ccaccccggc aggcggcagc agacagtggc ccgcacgggc ctgaggggcc tcctgtctgt    660
 ggtgcccatc ccaccgagag gatcctggcc cgcgagccgg cagacacttt attatacaga    720
 aacactatcg tcgtctccac gggcggaacc aacaaaagca agtctctcca agtcaaaaat    780
 aggttttgga ttcttggtgg cggcagtatc cgctgaaaaa atagactgaa cttctgaaat    840
 tatcttagta gcaaaacaat tacaagaaaa aagttgcaac ttcagtgcta tgactggaaa    900
 ggggcctttg gccggcggcc cctgttaccg gcggcccctg tgcgcctggg agctcctccg    960
 ggcttgagga agccgcccac gtgccctgat ggagaaaatg ggactccaac aggaggccgt   1020
 gtcctcacac ctcagactgc gctcacagct cgggaggatc aagttacaat aaacagtcca   1080
 ttaacttctt gctttcaggt ttccctggag tcaggcatct ctgcacagtc cagggcagcc   1140
 aggggctgca gagggtctgt gacaccccgc cacgatgcag cagtggggac acaagcctga   1200
 gggaacctgg agtgtggaga ggcaggagaa ggtgcaagga gaggctgcca tggtgtgcaa   1260
 ggaacctggg attgcgtctt taaatagttc tcagtcattc ttaaagtcct ccctcaagac   1320
 acaatgggac ctagattaaa gagaagccgt ctctccgctg tcccagggcg caggcggaat   1380
 gcccgagcgg tcttcggagg cacgggtgct ggtggcacct cactgaagct cagccgggct   1440
 gtcgccagcc catcatggcc tggcagctct gtctgctgtg aaggtgacaa tgccacagtc   1500
 ctcggggcag gaacgcccct cactgcatcc tgtcaggctg cagctgcggc gcctggtact   1560
 gcacgaaagt ggtgcccgcg ggtgctgcgg ctgagagggc ctggggcacg gcggcagggt   1620
 agctgtagcc cacgaagctg gcagccgtgg caggcgaggc ggcgtatggg tactggtcat   1680
 aggtggccgg tgggtactgg gcgtaggccg ggctggccgg cgtgtactca atgtagggcg   1740
 aggacagcga cgggacaggg gcggctggga tcaccacgct gggctgcacg atggctggtg   1800
 ggtagatgta gtgcggggtc agcccgtaag tccgctggat caaggtgggg tgcagctgct   1860
 gcaccccaat ggcaaagccc gtctggaggc tccgcggctt ggcgcccaga tatgccaggt   1920
 tcacgttggc cttgcggccg tcgatgatgg ggttcgggtc tttgcaagcc ctctcagctg   1980
 ccgcccggtc ggccatggtc acgaagccgt agccgcggga cttgcccgtc tggcggtcgg   2040
 tgatgaccac ggcctcctcg atgtcgccga agccctcgaa gtacttcctg agcgaggcgt   2100
 cggtagtgtg gtacggcagg ccgcccacga agatcttggt gaacgtggtg cccttctgcg   2160
 agccgtacat gacgccgggg gcggccaggg gccgcgagaa acccgcgctc              2210



      <210> 1315
      <211> 2210
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2210)
      <223> n = a,t,c or g


      <400> 1315
 tttttttttt ttctttaaag aaaacaagtt ttatttttat catcagaaca ttctaataaa     60
 aatattatga tgagattagc tacctttatt ctctgagcct tgactctgtc acaggcctgc    120
 cctgggngcg cctgcacgct cagctccctg aggtaggtcc ggaggggggg agaccccccc    180
 gctgcccccc gcccctnggg cagggatacc ctttaccttt aatggtcccc tccttccaga    240
 cccccaacag cccttgggat gccccattag cagccctgcc acgggttggg aagaaactgg    300
 cctccaccct ccaccaaccc ccaagacagg caaggaaacc gtctcagggc tgggcacaac    360
 agcaggtggt gcgggggtag agggaagagg cgcacccttc tgcactcaac cgctccagcg    420
 ggcagagctg agggccactg ccccccccag gctggcacca ccatggtcta gaccccaagt    480
 ggcctgaatg ctgtggatca cttccttctc cccttccaca gtgtttgggg agttggggag    540
 gaagggaagg gagaggagtg tcaacgtcgc agtgacgggg tcctgagaca actcactctg    600
 ccaccccggc aggcggcagc agacagtggc ccgcacgggc ctgaggggcc tcctgtctgt    660
 ggtgcccatc ccaccgagag gatcctggcc cgcgagccgg cagacacttt attatacaga    720
 aacactatcg tcgtctccac gggcggaacc aacaaaagca agtctctcca agtcaaaaat    780
 aggttttgga ttcttggtgg cggcagtatc cgctgaaaaa atagactgaa cttctgaaat    840
 tatcttagta gcaaaacaat tacaagaaaa aagttgcaac ttcagtgcta tgactggaaa    900
 ggggcctttg gccggcggcc cctgttaccg gcggcccctg tgcgcctggg agctcctccg    960
 ggcttgagga agccgcccac gtgccctgat ggagaaaatg ggactccaac aggaggccgt   1020
 gtcctcacac ctcagactgc gctcacagct cgggaggatc aagttacaat aaacagtcca   1080
 ttaacttctt gctttcaggt ttccctggag tcaggcatct ctgcacagtc cagggcagcc   1140
 aggggctgca gagggtctgt gacaccccgc cacgatgcag cagtggggac acaagcctga   1200
 gggaacctgg agtgtggaga ggcaggagaa ggtgcaagga gaggctgcca tggtgtgcaa   1260
 ggaacctggg attgcgtctt taaatagttc tcagtcattc ttaaagtcct ccctcaagac   1320
 acaatgggac ctagattaaa gagaagccgt ctctccgctg tcccagggcg caggcggaat   1380
 gcccgagcgg tcttcggagg cacgggtgct ggtggcacct cactgaagct cagccgggct   1440
 gtcgccagcc catcatggcc tggcagctct gtctgctgtg aaggtgacaa tgccacagtc   1500
 ctcggggcag gaacgcccct cactgcatcc tgtcaggctg cagctgcggc gcctggtact   1560
 gcacgaaagt ggtgcccgcg ggtgctgcgg ctgagagggc ctggggcacg gcggcagggt   1620
 agctgtagcc cacgaagctg gcagccgtgg caggcgaggc ggcgtatggg tactggtcat   1680
 aggtggccgg tgggtactgg gcgtaggccg ggctggccgg cgtgtactca atgtagggcg   1740
 aggacagcga cgggacaggg gcggctggga tcaccacgct gggctgcacg atggctggtg   1800
 ggtagatgta gtgcggggtc agcccgtaag tccgctggat caaggtgggg tgcagctgct   1860
 gcaccccaat ggcaaagccc gtctggaggc tccgcggctt ggcgcccaga tatgccaggt   1920
 tcacgttggc cttgcggccg tcgatgatgg ggttcgggtc tttgcaagcc ctctcagctg   1980
 ccgcccggtc ggccatggtc acgaagccgt agccgcggga cttgcccgtc tggcggtcgg   2040
 tgatgaccac ggcctcctcg atgtcgccga agccctcgaa gtacttcctg agcgaggcgt   2100
 cggtagtgtg gtacggcagg ccgcccacga agatcttggt gaacgtggtg cccttctgcg   2160
 agccgtacat gacgccgggg gcggccaggg gccgcgagaa acccgcgctc              2210



      <210> 1316
      <211> 1376
      <212> DNA
      <213> Homo sapiens


      <400> 1316
 tgcgcatgcg cgtgagggct gccgcggcca ggcccagaca tgtccgtcct tgtaagttaa     60
 aagcttccat gggagccttc cttcctaatc aagatgcaaa taatacggca ctccgaacag    120
 acactaaaaa cagctctcat ctcaaagaac ccagtgcttg tatcacagta tgagaaatta    180
 gatgctgggg aacaacgttt aatgaatgaa gccttccagc cagccagtga tctctttgga    240
 cccattacct tgcattctcc atcagattgg atcacctccc accctgaggc tccccaagac    300
 tttgaacagt tcttcagtga tccttacaga aagacaccct ctccaaacaa acgcagcatt    360
 tatatacagt ccattggctc tctaggaaac accagaatta tcagtgaaga atatattaaa    420
 tggctcacgg gctactgtaa agcatatttc tatggcttga gagtaaaact cctagaacca    480
 gttcctgttt ctgtaacaag atgttccttt agagtcaatg agaacacaca caacctacaa    540
 attcatgcag gggacatcct gaagttcttg aaaaagaaga aacctgaaga tgccttctgt    600
 gttgtgggaa taacaatgat tgatctttac ccaagagact cgtggaattt tgtctttgga    660
 caggcctctt tgacagatgg tgtggggata ttcagctttg ccaggtatgg cagtgatttt    720
 tatagcatgc actataaagg caaagtgaag aagctcaaga aaacatcttc aagtgactat    780
 tcaattttcg acaactatta tattccagaa ataactagtg ttttactact tcgatcctgt    840
 aagactttaa cccatgagat cggacacata tttggactgc gacactgcca gtggcttgca    900
 tgcctcatgc aaggctccaa ccacttggaa gaagctgacc ggcgccctct aaacctttgc    960
 cctatctgtt tgcacaagtt gcagtgtgct gttggcttca gcattgtaga aagatacaaa   1020
 gcactggtga ggtggattga tgatgaatct tctgacacac ctggagcaac tccagaacac   1080
 agtcacgagg ataatgggaa tttaccgaaa cccgtggaag cctttaagga atggaaagag   1140
 tggataataa aatgcctggc tgttctccaa aaatgaggac cttcaaatag gagtgattga   1200
 aataaataac tacttgcatg ttatgctttc atttgggtgg aatacttcat tggaataaac   1260
 tactgatctt gtgctgtgtc aaagtaacag actagaacct tctttcaagt acctgaattg   1320
 aaatgaaact cattttgaat aataaaaact ctagaaactc tttaaaaaaa aaaaaa       1376



      <210> 1317
      <211> 2359
      <212> DNA
      <213> Homo sapiens


      <400> 1317
 cttaccttag aaaaccaaat taaagaagaa agagaacaag acaactctga atctccaaat     60
 ggcagaacat cacctcttgt gtcccagaat aatgaacaag gctcaacctt acgggatttg    120
 ctgactacaa cagctggaaa gctacgtgtg gggtctacag atgctggcat tgcctttgcc    180
 ccagtatatt caatgggagc cccaagtagc aaaagtggac ggactatgcc taacattctt    240
 gatgacataa ttgcttcagt tgttgaaaac aaaattccac caagtaaaac ctccaagata    300
 aatgtaaaac cagagcttaa agaagagcct gaagaaagca taatatctgc agtggatgaa    360
 aataataaat tatacagtga tataccacat tcttggatct gtgagaagca tattttatgg    420
 cttaaggatt ataagaatag cagtaattgg aagcttttca aagaatgttg gaaacaagga    480
 cagcctgcag tggtttctgg tgtgcataag aaaatgaaca ttagcctatg gaaggcggaa    540
 tcaattagtc ttgattttgg agaccaccaa gctgatctcc tgaactgcaa agatagcatc    600
 atttcaaatg ccaatgttaa ggaattctgg gatggttttg aagaagtttc aaaacggcag    660
 aaaaacaaga gtggagaaac agttgtttta aaattgaaag attggccttc aggagaagac    720
 ttcaagacta tgatgccagc aagatacgaa gatcttttaa aaagtctgcc attgccagaa    780
 tattgtaatc cagaaggaaa attcaatttg gcctctcatt tgccaggatt ttttgtacgt    840
 cctgatctag gacccaggtt gtgcagtgcc tatggtgtag ttgctgctaa agatcatgat    900
 ataggaacaa caaatctcca tattgaagtt tctgatgttg taaatatact agtttatgtt    960
 ggcatagcaa aaggaaatgg cattctctca aaagcaggaa ttctcaagaa atttgaggaa   1020
 gaagatttgg atgacatttt aaggaaaaga ttgaaggact caagtgaaat acctggtgct   1080
 ctgtggcata tttatgctgg gaaagatgtt gacaagataa gggaatttct tcaaaagatt   1140
 tcaaaagaac aaggccttga agttctacca gaacatgatc caatacgtga ccaaagttgg   1200
 tatgtgaaca aaaagctccg tcaaaggctg cttgaagaat atggagtcag aacctgtact   1260
 cttattcagt tccttggtga tgctattgtt ttgccagcgg gagcacttca tcaggttcag   1320
 aattttcaca gctgtattca ggtaactgaa gattttgtgt ctccagaaca tcttgtagag   1380
 tcatttcatt taacacagga actgagactt ttgaaggaag aaatcaatta tgatgataaa   1440
 ctacaggtta aaaatatttt gtatcatgca gtcaaagaaa tggtgagagc cttgaagata   1500
 cacgaggatg aagtagacga tatggaagaa aattaagtgt gatccagttt gatattttta   1560
 ggttgttgaa ctgggattac ttaaccttga atgatgatat gtatgcacac tgactttaag   1620
 cttcataaaa ccatcagtgc caagaaattc tctttgtagt aattacttgt tactgacacc   1680
 acagcagtat agcatatgtc acagctcctg tgattcaatg ttataaaaca agcagaattt   1740
 taaaagcagc actatatagc tgttttgtat tatagtgtat atgatgtttg tgaaaatgcc   1800
 agatttaaaa tgatgtattt atttttggta aaaaataaaa aattctatgc tatattgttg   1860
 atcaagtgta aatgtgacct tgtacagttt actaaaatta ctgatatttt tcactacatt   1920
 gagacagtta ctgtgagaat aggacacaaa ctccagctat tgcctgcatc tgggaaattg   1980
 ctgaatcgca cagcagtcat gtcataatca gaaaattact gccaaataat tgtaaaattt   2040
 gtaaagtata aagtatataa agtagatact aaatacagac acttcaatat tttgttgaag   2100
 ctattgactg tacaattaaa cattttcaaa aggtgtaatt tatttaaaat tgtctcattt   2160
 tggtaaaatt tatgtgaact tttaaagcta aatattaaac ttaatatgct atgtaaatat   2220
 atacatatat acatttaatg atgtattttt ttaaaacatt ggcttgcttt tgttaaagtg   2280
 caagtgttac atatggcttt gtacattaaa gttgaaaggg gttttacatt ttccattaaa   2340
 aggactttat caaaaattg                                                2359



      <210> 1318
      <211> 886
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(886)
      <223> n = a,t,c or g


      <400> 1318
 tttttatttt tttgcttttt aaaagttttt atttcaaaaa ataaagctgc agttcatttc     60
 acataaatat ctggggaggg aaggggagtg ggatggggtg ggggcttggc ccctacctcc    120
 tcttctcttt cacactgtat tgtaaaagca aaggggatgg cttgccgaac cagcgggaga    180
 gccatatctg cttcattgtc atgtgatcag ggagaacttc attgtcaaaa aggagctgca    240
 catgctgagg gtttagcatc aagcggtgac acaggaccct ccggagatgg cgtacctcag    300
 ctctaacaga acatcggaca tacttgttct gcaggacgct tttattcttg tctttgccag    360
 aactcagccg ctccaggcac aggttcaact gctcatcata gcgatagtag tgggctttag    420
 agtggtcaaa gctgctgaag gggaggccga ggttgctcag tgctggctct tccccagtgg    480
 gctgggtgac ccggtccaaa cctcgggact ggtagaattc ccgaatccgt ttctcttcac    540
 tgtcttgcaa gccaggcacc agcttataca cgatgtcctg catgacccgg tccagtttga    600
 ggttgagcag tggctgtgtc tcgtggatct taatgttgca catggggcag tacttgctag    660
 tttggaggta cttcacaata caactcttgc agaaagtatg aagacactct gtgatggtgg    720
 tggcatccac gaagtagccg gcgcataggc agcaaacaat gtgttcattc aagtctttga    780
 tcttcactcg aacctcctcc tgaccctcct ttcccagggg agactacaca acgtcggcga    840
 cacaacgcgc aggcggaatt ccaccgcntg gactaatgtc tacaat                   886



      <210> 1319
      <211> 853
      <212> DNA
      <213> Homo sapiens


      <400> 1319
 tttttttttt ttttttgata aacagacatg tttaatgata gcttgctctt cacagagatg     60
 tctacagaga cttttaatct ataatccagg agtatataac catgcagcac agaccaatta    120
 gccaaatgca aaataaacta gattcttacc acaactatcc tataaacact gcaactattc    180
 tttccaaaag gaccctaatc ttatgtgaaa aacacctact gtgggggaac cagaaaccta    240
 gctatctggc caaaaaggaa aaaatagcaa ttcagtggtt aaattggtga aagcaggaaa    300
 tgtatgccct ttaactgtgc tgcttgtttg ctggctggtt ggttggctgg ctggttggtt    360
 ggctggcttg tttggcttgc ttgcgggcaa ggtgcttgct tgcttgctgc tgcctgttgt    420
 tgactgctgt tgctgcctgc ctttgggtcc ttccttaatt ttgttctttt tgtctctcct    480
 tccttcaaac cccatcccat gttagcttct taaggaggtt tgaaataagc cattctgaaa    540
 acttattcac attccttgga agctcaccac agtgctgatc ttcttcttcc catcgggtag    600
 ctcttaacag acacttgttg tcctggcggg ctcaaagcca tccaaaagta ccttttcttt    660
 ggaatgggtt tggttcggac cgtcatactt cttcaaggtg atataggacg ctggcccgac    720
 gtccgggcac ttctggaaaa agtctggtca gctcccgtca ggaactgctc ggctctccaa    780
 caacaccaac tcgcggcgac gctggctcga ctccctcggc ttaagcccct agcagtgaga    840
 gccggagtcg acc                                                       853



      <210> 1320
      <211> 425
      <212> DNA
      <213> Homo sapiens


      <400> 1320
 ccaccgtgcc ctctttgcca aataaaaaaa tgaagcgtgg tcttcagtat gaatcaatgt     60
 gttattgttg ccacccccca cggtatccat gctcagtgtc aacctttcat ggagcactca    120
 tctgttacgc tggatcacct tcttctattt gtcaatcggc acggctcact tgtaccactg    180
 gctggagatg cggaccaaaa tgcgcatcat gggtttcaat gccgctgcca tcaagccgct    240
 gaacgagggt gcagccgccg agctgggcgc ggagctgctg ggcgagggca tcatcttcat    300
 caccgcctgc agctgcctga tgctggagta ttggcgccac cagttgcagc agcgccgcaa    360
 ggaaaaggag cgacgtgttg ccagggaggc gctgcggggc gaggtgggcc acttggggct    420
 ggcgc                                                                425



      <210> 1321
      <211> 987
      <212> DNA
      <213> Homo sapiens


      <400> 1321
 cggcctcaag atggccgcct tctggcgtct ccggcgctgt tgaatggcga aagctttatt     60
 gttcccttcg ggcaggagtg ttcgtgtcct ctatggagct gtcaataaag aacggcagtt    120
 tgaatcggtg ctgaacaggg cctgtcctcc caaagccaac tctaaggaga ggagaggaag    180
 agcagttctt ggggcagagt tgacgcaatg gagctcccca actacagccg gcagctgctg    240
 cagcagctgt acactctgtg caaggagcag cagttctgtg attgcaccat ctccattggt    300
 accatttact tcagggctca caagcttgtc ctggctgctg ccagcctcct gttcaaaacc    360
 ctgctggata acacagatac catctccatc gatgcatctg tggtgagccc cgaggagttt    420
 gcgctcttgt tggaaatgat gtacacgggc aaactacctg tgggcaagca caacttctcc    480
 aaaatcatct ccttagcaga cagtctacag atgtttgatg tagctgttag ctgcaaaaat    540
 cttctgacca gccttgtaaa ctgctcggtt cagggtcagg tggtaaggga tgtctctgcg    600
 ccatcctcag agacattcag aaaggaacca gagaagcctc aagtagaaat cctttcatct    660
 gaaggtgctg gagagcctca ttcttcccca gagcttgctg ccactccagg gggccctgtg    720
 aaagctgaga ctgaggaagc agcccattca gtttcacaag agatgagtgt gaattctccc    780
 acagcccagg agagccagag gaatgcagaa accccagcgg agactcctac tacagctgaa    840
 gcttgttccc cctcccctgc tgtgcaaacc tttagtgagg caaagaagac aagcacagaa    900
 ccagaaaggc ttgccctcat ggtgacagaa atggcagcag ctgctctaac ttcaggtgca    960
 atccaacaga aagtggccaa agccatg                                        987



      <210> 1322
      <211> 377
      <212> DNA
      <213> Homo sapiens


      <400> 1322
 gcaagggata gcattgctga ccagaatggg cgagtcagtc aagcacgtca ctggcggcta     60
 caagctgagg actcggccgc ttgagtttgc tgccataggt gactacttag atacatttgc    120
 actcaaactg ggaaccattg atcgaatagc ccagcggatc atcaaagaag aaatagagta    180
 ccttgtggag ctgagagaat acgggcctgt gtactccaca tggagcgcct tggagggtga    240
 gctggctgaa cccctggagg gtgtgtcagc ttgcattggg aactgctcta cagccttata    300
 agagctgaca gatgacatga cagaagactt cctatttgtg ctcagggaat atattttata    360
 ctctgactcc atgaagg                                                   377



      <210> 1323
      <211> 441
      <212> DNA
      <213> Homo sapiens


      <400> 1323
 ctggtggaat tcgaagcaaa gggtgtagct gatgtgcaga ttgggattga atgtgggaat     60
 gagggtgtga tgggagtgat tggaaatatt gcagccctgc atagtctcca tcagggatgt    120
 gacaaagtgg ataatctcta ccacgtgaga aacttccaac attacttgca aatcagattt    180
 aatgaataaa ataaagctgt agcacttggc acattcattg ggacccttac ccaaacatta    240
 tcaatattgt gtacgttatc tttattatca ggtcacaaaa gatgtcataa aagaatttgc    300
 agatgacggc gtcaagtacc tggaactaag gagcacaccc agaagagaaa atgctactgg    360
 aatgactaaa aagacttatg tggaatctat acttgaaggt ataaaacagt ccaaacaaga    420
 aaacttggac attgatgtta g                                              441



      <210> 1324
      <211> 2210
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2210)
      <223> n = a,t,c or g


      <400> 1324
 tttttttttt ttctttaaag aaaacaagtt ttatttttat catcagaaca ttctaataaa     60
 aatattatga tgagattagc tacctttatt ctctgagcct tgactctgtc acaggcctgc    120
 cctgggngcg cctgcacgct cagctccctg aggtaggtcc ggaggggggg agaccccccc    180
 gctgcccccc gcccctnggg cagggatacc ctttaccttt aatggtcccc tccttccaga    240
 cccccaacag cccttgggat gccccattag cagccctgcc acgggttggg aagaaactgg    300
 cctccaccct ccaccaaccc ccaagacagg caaggaaacc gtctcagggc tgggcacaac    360
 agcaggtggt gcgggggtag agggaagagg cgcacccttc tgcactcaac cgctccagcg    420
 ggcagagctg agggccactg ccccccccag gctggcacca ccatggtcta gaccccaagt    480
 ggcctgaatg ctgtggatca cttccttctc cccttccaca gtgtttgggg agttggggag    540
 gaagggaagg gagaggagtg tcaacgtcgc agtgacgggg tcctgagaca actcactctg    600
 ccaccccggc aggcggcagc agacagtggc ccgcacgggc ctgaggggcc tcctgtctgt    660
 ggtgcccatc ccaccgagag gatcctggcc cgcgagccgg cagacacttt attatacaga    720
 aacactatcg tcgtctccac gggcggaacc aacaaaagca agtctctcca agtcaaaaat    780
 aggttttgga ttcttggtgg cggcagtatc cgctgaaaaa atagactgaa cttctgaaat    840
 tatcttagta gcaaaacaat tacaagaaaa aagttgcaac ttcagtgcta tgactggaaa    900
 ggggcctttg gccggcggcc cctgttaccg gcggcccctg tgcgcctggg agctcctccg    960
 ggcttgagga agccgcccac gtgccctgat ggagaaaatg ggactccaac aggaggccgt   1020
 gtcctcacac ctcagactgc gctcacagct cgggaggatc aagttacaat aaacagtcca   1080
 ttaacttctt gctttcaggt ttccctggag tcaggcatct ctgcacagtc cagggcagcc   1140
 aggggctgca gagggtctgt gacaccccgc cacgatgcag cagtggggac acaagcctga   1200
 gggaacctgg agtgtggaga ggcaggagaa ggtgcaagga gaggctgcca tggtgtgcaa   1260
 ggaacctggg attgcgtctt taaatagttc tcagtcattc ttaaagtcct ccctcaagac   1320
 acaatgggac ctagattaaa gagaagccgt ctctccgctg tcccagggcg caggcggaat   1380
 gcccgagcgg tcttcggagg cacgggtgct ggtggcacct cactgaagct cagccgggct   1440
 gtcgccagcc catcatggcc tggcagctct gtctgctgtg aaggtgacaa tgccacagtc   1500
 ctcggggcag gaacgcccct cactgcatcc tgtcaggctg cagctgcggc gcctggtact   1560
 gcacgaaagt ggtgcccgcg ggtgctgcgg ctgagagggc ctggggcacg gcggcagggt   1620
 agctgtagcc cacgaagctg gcagccgtgg caggcgaggc ggcgtatggg tactggtcat   1680
 aggtggccgg tgggtactgg gcgtaggccg ggctggccgg cgtgtactca atgtagggcg   1740
 aggacagcga cgggacaggg gcggctggga tcaccacgct gggctgcacg atggctggtg   1800
 ggtagatgta gtgcggggtc agcccgtaag tccgctggat caaggtgggg tgcagctgct   1860
 gcaccccaat ggcaaagccc gtctggaggc tccgcggctt ggcgcccaga tatgccaggt   1920
 tcacgttggc cttgcggccg tcgatgatgg ggttcgggtc tttgcaagcc ctctcagctg   1980
 ccgcccggtc ggccatggtc acgaagccgt agccgcggga cttgcccgtc tggcggtcgg   2040
 tgatgaccac ggcctcctcg atgtcgccga agccctcgaa gtacttcctg agcgaggcgt   2100
 cggtagtgtg gtacggcagg ccgcccacga agatcttggt gaacgtggtg cccttctgcg   2160
 agccgtacat gacgccgggg gcggccaggg gccgcgagaa acccgcgctc              2210



      <210> 1325
      <211> 1192
      <212> DNA
      <213> Homo sapiens


      <400> 1325
 ccccttttga aagtagcaga aattttaaaa gaaaaggaat tttgtcctgg agaaagaaat     60
 agttatgaac ccatcaaaga gtttcagaaa gaagctgaaa aattcttgcc actttttggg    120
 cacataggtg gtacacaaag caaaggacca tgggaagaat tggcaaaggg aagtccacat    180
 agcgtcatta atatttttac aaaatcctat cagttatatg gaaaagggtt tgaagacaag    240
 ttggacagag gaacatcaac atcacggcct ttgaatgcca ccgcaactcc tctaagtggt    300
 gtttcatatg aagatgattt tgtctcctct ccagggactg ggacttcgac agaaaaaaaa    360
 tcaactcttg aacctcatag cactttaagc cctcaggagg accattctaa cagaaagtct    420
 gcctatgatc cttcctctgt ggatgttacc tcccagcatt catcaggagc ccagtctgct    480
 gcatcgtctc gttcatctac ttcttctaaa ggaaagaaag gaaaaaagga aaagacagaa    540
 tggttggatt cattcactgg aaatgttcag aactcacttc ttgatgagga aaaagcagaa    600
 cgtggctccc atcaaggaaa gaaatctggg accagcagca aactttctgt taaagatttt    660
 gagcagactc ttgatacaga tagcactttg gaggatcttt ctggacattc tgtgagtgtc    720
 tcatcagata agggaagatc tcagaaaact ccaacttctc ccctgtcacc aagttcccag    780
 aaatcattgc agtttgacgt tgcaggaact tcttcagaaa gatctaagtc gtcagtaatg    840
 cctccaacta taacaggatt taagcctaat gcacctctca ctgatctgaa cccggcagcc    900
 agcagaacaa cgacagagaa catggctcca ataccaggtt ctaagcgctt ttctcctgct    960
 ggcctccatc atcgtatggc agcagaactc agttatctga acgccattga ggagtcggtg   1020
 cgccaactgt cagatgtaga aagagttaga ggcatttcac ttgctcagca ggagagtgtg   1080
 tctctagctc agataataaa ggcacaacag caacgccatg aaagagactt ggccctcttg   1140
 aaactaaagg ctgaacaaga ggctctggag agtcagagac aaaaaaaaaa aa           1192



      <210> 1326
      <211> 5020
      <212> DNA
      <213> Homo sapiens


      <400> 1326
 aatatcccat ggcttacctt ttattttttt attataaaaa cacatacaag agttttaaga     60
 aataacgaat ataagacaaa tcaaaaccat ggtgagttat taaacccatt ttctatatac    120
 aaatactaaa attcccaaag tggaatatca tccaatgtga gacacatcat agcacggtcc    180
 atatgtacac ggcacacaga gctctgcctg cgctcatctg tgaattgctc attacatgtc    240
 actgataaaa aaatctgcaa gggaacttct actcttcagt tctcctcttc ctgatgcatt    300
 gtcacatatt tttaaggaac tttagggata tgaagaaaat gcattaaagt gggtttctgc    360
 taagggctct gcatgttttg ctctgatcaa ttacgcacta catcttgaga aaaacttttg    420
 caactcattt ccagcaaaga tagcagaaaa ctctaggttt ttgccaattt attttttcct    480
 agtcactcat tggaacacaa gtccaacaac aacagctcag gaaccaaatc atgtttttat    540
 attggtaagt tcattataaa atgccactca attttaagaa gccactaaaa ggacactttc    600
 tgcagcaaaa aaagggctaa gttcaagttt ttgttgtttg acaaagacac aataatataa    660
 cccatatgtc acagatcaca acagccttaa gtgaaacgta ttagatttag ggaaaaacga    720
 ctatgcgact gcttgtttct cctgtctcct tgccaaacaa taaggagagc ctctggtctg    780
 ttttatctat tttatgtctt tttgttttga aacctccctt tgtattctga aagctgatca    840
 aactatttgt gttcaaaatg tgtcaaggca cttctcaagc ctcagtggca tcccaggtca    900
 gccaagctcc tctgtgctca gggcactgac ttcctctagg cagctgacaa tcgcagacgg    960
 aacgcttttg gaggcctctc tccgccaagc ttccaggatc ttggaaattt ctgctggatt   1020
 gctgggactc aagtcacaaa gagcatacac ggctgctaac tgtatacccc atggtatatc   1080
 ttcatcgtga gcatgctgta taaacatacc aataaccgaa ctaatatttt tcacagcaga   1140
 tggaaatcct tctttcaaac ccaattggcc taaacgacca atcagcctca gtattgaggc   1200
 tataataata tcaggagtat acgcaatgtt tgcatgtcct tttctgtatt ttatccattt   1260
 atccatcaca ggccacagct ccttacttat gatgttatca tgcgtccaga tccatttctg   1320
 atggcagcag agcagatcaa tggcaaatat gtattcccaa gtgttatcac ttaggtcttc   1380
 accaaatttt tcactaggtt gaaattctgt ttttggacat aactgtatgg tcaaaagcag   1440
 cttagaaacc atgaagccaa catctaccgg ggcattcttt tcccaattaa gaaaagctct   1500
 caagcagttc agaacctctc ctttagcacg ttgcctggca actaactgca ttgctttatt   1560
 aatcaccgat tgagagagaa atatatcatg ccacatgttt gcaataaaca aagttaattt   1620
 ttcagactcc ggaaaatctt cttttaagta ggctgtagca aaacaaacga gctctttcca   1680
 agtctccgag ttgccgacaa atacccacat acaccctgca gagggcgtga atgtaattgt   1740
 ggtccataga tatcttctga atttttagtt ctgagagaat agagtgaagc aagcactctg   1800
 ctaaatgctt ttttgttgtg ctaaattcat aaacaacttc cttctcttga tctctcatta   1860
 cgggcttttt ggagatattt cccacataca catgactacg aatgacaggt aacagatcaa   1920
 aagaaaactc tgcaattttc ttcagggcat tagctatggc tttatcatgg gactccacag   1980
 tttcttttgg gcttaaaggc aactgtgaaa ctgcactgac ggctggacta gaacaacttc   2040
 tttcctcatt tgttgttgca acttcagctg gagggaggtt ccctgggagg tttttgtgga   2100
 ttccttctgc agtgactccc ctggtttctg gttctgggga cccagtgtcc aggcgcagtc   2160
 ttttagcact tctcagtgta gacgttgaca gtgttctttt cccgcttgaa tcctgctgag   2220
 tccccaaatc tcttgacttg tcttggttac agtcaccacc agagctgctc ccagttttga   2280
 caaaagcagt tgctgctgaa gtgatcgttt tgaatcctat catagcactg gcaggtcccg   2340
 gtaaattctt acagtcagca ggcggacctc gtgtgagttg aatattccct ttgaggatgt   2400
 tgagggtccg ggccctggca gataactctg gatacatggt gtcaaggatt ttcacagaat   2460
 tctcctgagg ccctcccaca gcagcgtggc cagatgcaca gggtgggagt cggccaggca   2520
 caggaagtgc gtgcttcggc gtggccgcac agaactgcag aggagacggc actaccctct   2580
 cactggctga agctgcagat ggagatggag aaggatctgg aggagaggca cgtctggggt   2640
 cctctggcca tggagacatg gcaggaggca ctggggtttc acggaaggga gaaacctggc   2700
 caacaggaga ggctggtgag gaaggactag aactcgatat cagtggagac agtggctgtg   2760
 aagtccttgg aggtgtagct atcagaggag caagcagagg cggcaaagga ggccccacct   2820
 cttgccgtat tttactcagt gtgtcaggag aacaatctgt aggagtggat gtatcagcat   2880
 ttgctaaaat ggtctgagtt tggcttcttt gagtttttgt attagctttt tcccctgaaa   2940
 atgactgagc aacttcactc tgatgagttt caactctgct cgacgctgaa gtttttactg   3000
 gtttgtttga ctgatctttg tttgaaatct ttgatcgatt cttatttttg ccagatggct   3060
 ctagttttga gttataatat gtgtgatcag acgcaacaat ctgagtctcg aagttttgat   3120
 catagatttg agaactaatc catatactag gcttaacggg tctatttcgc aaacgactct   3180
 tatcaaagtt ggtgctctga ccactgcttg aaacatcctc ttggggacat gaaagattat   3240
 tgccacatgg agcctcctga aatgcagggc cagtgtgact ggcctctggg gacttctcag   3300
 cagaagtcac tgggatgcaa ccagcttcca gctctccttg atcctgagaa atagggatgt   3360
 ctccaggaat gtcacacagt gtgacctggt ccacatgtgg caagacagct acaccactga   3420
 tgattgtcca gttgtccccc ttttcaatga ctagattctg atccttattt ataagtacgt   3480
 ttataacttc tgaggtcact gttgctatct gacactgaaa tgttgtttcg gcctcgcagt   3540
 tagaactttg ctctatggat ggctccatca cagagtcaga gcacaaggct gatggctcca   3600
 caggttctgg caggtcttct tccccaccat cggtttgcct gcctgcatct gaacgggcct   3660
 ctggtctgct ctgagggttt tcattctgag gcataccgct gatgggagag ctgccctcag   3720
 tgtccaaggc agctgcttgt ggggttggtt ctgaagcatg tgatgaggag ccagtcgttt   3780
 cccgaaatgg acttttctct tttaaattct cagtggtcat gttgttattt acatttaaga   3840
 gcaataaact gccagtatct ttaccattgc aatcttcaga atttgtttga agttcttgcc   3900
 taatcttggt cagaacctca gacagagttt ccaaagaaca ctgagtgagc tgacttgtat   3960
 tttttaacga ataatcatct tcctctgatt caatccactc ttcacaggtt ccaagtgttt   4020
 cttcctcaca gggttgcttt ctgtattttt ctcctatttc acttgccttt aattctttgt   4080
 tcatttcttt acttagggtt cctttactag aacattcaga aacagagtcc cctgaactat   4140
 aatcccctaa ctgacagctc tcaagaaaca tcacaacctc tgatgtggaa agtctatcca   4200
 gctcagaaaa agtacttatg ttaaaatctt gcagagctga cgtcaaataa cctacctcta   4260
 aggaaggtct cacctcggct acagcagcat ctgtgtctcc taaatttttc tgtgagtcat   4320
 caggagcatc ttgctgttcg ctcccctcac tgcagctaaa tgcctcactc tctacctcag   4380
 tgtcgtctcc cccctctcga atgcctgtgt aacaatgtaa ggtaccaggc aggctacttt   4440
 gggaggtatc ctgtgtctct ccatgttttc tgcaaaatgc tgaagaaaaa gtagtgtctg   4500
 tggtgccaaa acactcaggc aaagcaccac cgggagttgt agatttcaat ttccaaagtc   4560
 cattagcatt ttgtggtgtg ctggtagaat catttgcaac agccagggcc tcaccaccag   4620
 atctccctgt gtctccacag ctggtttctt caacagaaaa ccctcctgac acagtcactt   4680
 ctgtggctgg aagcatctca ctgccatgtg tcccactgga gtccagatct gtggcctgag   4740
 gctgcctttg cttctgccca tctccctgca ctgcagcttc tctcacaatg tcttggtttt   4800
 ggatgaggat attttcagga gagaaagata atctgctatt tgtggaacaa tcagaatttt   4860
 ctactggtga agaaccacct ggagaattaa aatctaattt tctcctagag gcagaaactt   4920
 ctggtgaaat gcttttcaca gcagccacct ccgtgatgtt ttgtgttgta tcatctcttt   4980
 ccccatcaca ttttgctata gttgacatac cggttttgtt                         5020



      <210> 1327
      <211> 640
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(640)
      <223> n = a,t,c or g


      <400> 1327
 tacccgtctc gaattcccgg gtcgacgctt tcgtggcggc ggcggcggcg gcagagggag     60
 tttccgcttt gcactccacc ccggtagcag ctccgcggca gggacagctt cctccggacg    120
 cttggcgggc ttcgctctcg ccttacgaca gcccggtcgg atcatggggt tgcccagggg    180
 gccggagggc cagggtctcc cggaggtgga aacaagagaa gatgaagaac aaaatgtcaa    240
 gttgactgaa attctggagc tcttggttgc agctgggtat ttcagggcaa gaattaaagg    300
 cttatcaccc tttgacaagg tagtaggagg aatgacttgg tgtatcacca cttgcaactt    360
 tgatgtagat gttgatttgc tctttcaaga aaactctacg ataggtcaaa aaatagctct    420
 gtcagaaaaa attgtctcgg tcctgccaag gatgaaatgc ccacaccagc tggagcccca    480
 ccagatccag gggatggatt ttattcacat atttcctgtt gttcagtggc tggtgaaacg    540
 agctatacaa acaaaagaag agatgggtga ctatatccgc tcctactctg tatcccagnt    600
 ccagaagact tacagtctcc ctgaggatga tgacttcatg                          640



      <210> 1328
      <211> 2174
      <212> DNA
      <213> Homo sapiens


      <400> 1328
 tttttttttt ttcatgccaa tgaatttatt gaaacggagg tctgtacaca ggcaaacctg     60
 tactgtggaa actaagacat caggagctct ctccactccc ctggccctcc agggtggggt    120
 gaggagggag tagaccttgg gggcagagga caggagggga gttacagctg taggaggggc    180
 ggggccaggt tggacggtgc gaatcgacgt tttctttaag aaaaaaatta taacaatcta    240
 tttacacccg ggggccaggg aagggaagag gagacgggct gggctggttc tatttacaag    300
 ggacacacag aggggagggg gtctggagga ggtgaaaatc tgggggaggt ggaaagggcc    360
 aagggggtaa ggaagtcctc atccccccaa cacccctgtc cttctcttcc cctcccccac    420
 aaccagttta aaatcctcct taaaaagccc caccacaggg gtgaggctgg tgagggaggg    480
 actggaggtg gggacaggga ctcatttacc tctgccctct agtctagggg cccagccagg    540
 gcaggagctt gatgggctat ggcccccctt cccagcccct cttggggctc ccagatggaa    600
 gtggaagggt gcttggtggg gccctcagga ggagttagtg agggtaggtg tggcatcggt    660
 cgactgccag tctgagctgg tcggagtctc agttaaagct tgtgaggacg gggtgaaggg    720
 tggtagtgcc cgctggggaa cctccaagtg aaggagggat gagaatggcg ttgagagacg    780
 gttggattgg agagttcacc agcactgaag ttgaagagag ggggaagtgg gcggttgtta    840
 ggcagctggg ttcccagaca tcgcagttca tcaaagaagc tgtgcgcaca ggcctctagt    900
 ggggagagcc ttgaggatgg ggtgtactcc cagcaggcta gagcagagcg cgatggcctc    960
 tggcggcgtt cgagatttga acacttttgt cccaggggtg agctttaatc tgagggaact   1020
 tgaactccgt gtagttgggg ttcatctctc ggatttgttc ccgggttggt gttcccagca   1080
 ccttgatgat ctccaccagc tggtccaccc cactgtcccc agggaagatg ggctggccca   1140
 agaggagctc tgccagtaca cagccagctg accaaacatc gatggatgag gtgtaatcag   1200
 tggctccaaa gatgagctct ggggcccggt agtagcgaga acagatgtag gagacattgg   1260
 gctcccctcg gaccaactgc tttgcactgc caaaatcgca gagcttgagg acagcagtgt   1320
 cagggtccac cagcaggttc tggggcttga tgtcgcggtg acacacgccc tgggagtgga   1380
 tgtaggccaa gctgcggaag agctggtaca tgtacacctt gacatagagg atagggatgg   1440
 tcaacttggc cttggtgaag tggcgggcca cccggtacac tgtctcgggc acatattcca   1500
 gcaccagatt taggtaaagc tcgtctttct tctcgccact ggagtagaaa aagtatctca   1560
 gcctcacaat attgcagtgg tccagcttac gcatgatctg cagctctcgg ttcttgaacc   1620
 tcttgtcctg gagaaccttc ttgatggcga ctagttccct ggtctctgcc agccgtgcct   1680
 ggtacacgac cccaaatgag ccattgccaa tcactttgat gtccgtgtaa gccacttctt   1740
 gggagcgctc tgggccttgg cctagagtgg ctacgactgt ggtcaccttc ccgctgtcac   1800
 ggcccagctt caccccgggc ggcgggaagc tagtgcctgc gccggggcct ccgctgcctc   1860
 ctccgccgct gccgccgggt ccacccccgg agctcgaggc cccgacgccc ccacccatgg   1920
 ccccgacaga tgcctttccg ccgccggtgc cgcctgggcc ggaggccgag cctccggggc   1980
 cgccgccgcc tcctccgcct ccgccgccgg gctccgcgaa cgagctagtc cgcgccctgc   2040
 ccgagccccc agggccgcct cccgaaggcc cgccgccgct catggcgccg agcacaggcc   2100
 caggctgcgg ggctcgggct gcccgggctg ccccagccgc cgccgcggcc gccgcctccc   2160
 ccggagccca agcc                                                     2174



      <210> 1329
      <211> 2174
      <212> DNA
      <213> Homo sapiens


      <400> 1329
 tttttttttt ttcatgccaa tgaatttatt gaaacggagg tctgtacaca ggcaaacctg     60
 tactgtggaa actaagacat caggagctct ctccactccc ctggccctcc agggtggggt    120
 gaggagggag tagaccttgg gggcagagga caggagggga gttacagctg taggaggggc    180
 ggggccaggt tggacggtgc gaatcgacgt tttctttaag aaaaaaatta taacaatcta    240
 tttacacccg ggggccaggg aagggaagag gagacgggct gggctggttc tatttacaag    300
 ggacacacag aggggagggg gtctggagga ggtgaaaatc tgggggaggt ggaaagggcc    360
 aagggggtaa ggaagtcctc atccccccaa cacccctgtc cttctcttcc cctcccccac    420
 aaccagttta aaatcctcct taaaaagccc caccacaggg gtgaggctgg tgagggaggg    480
 actggaggtg gggacaggga ctcatttacc tctgccctct agtctagggg cccagccagg    540
 gcaggagctt gatgggctat ggcccccctt cccagcccct cttggggctc ccagatggaa    600
 gtggaagggt gcttggtggg gccctcagga ggagttagtg agggtaggtg tggcatcggt    660
 cgactgccag tctgagctgg tcggagtctc agttaaagct tgtgaggacg gggtgaaggg    720
 tggtagtgcc cgctggggaa cctccaagtg aaggagggat gagaatggcg ttgagagacg    780
 gttggattgg agagttcacc agcactgaag ttgaagagag ggggaagtgg gcggttgtta    840
 ggcagctggg ttcccagaca tcgcagttca tcaaagaagc tgtgcgcaca ggcctctagt    900
 ggggagagcc ttgaggatgg ggtgtactcc cagcaggcta gagcagagcg cgatggcctc    960
 tggcggcgtt cgagatttga acacttttgt cccaggggtg agctttaatc tgagggaact   1020
 tgaactccgt gtagttgggg ttcatctctc ggatttgttc ccgggttggt gttcccagca   1080
 ccttgatgat ctccaccagc tggtccaccc cactgtcccc agggaagatg ggctggccca   1140
 agaggagctc tgccagtaca cagccagctg accaaacatc gatggatgag gtgtaatcag   1200
 tggctccaaa gatgagctct ggggcccggt agtagcgaga acagatgtag gagacattgg   1260
 gctcccctcg gaccaactgc tttgcactgc caaaatcgca gagcttgagg acagcagtgt   1320
 cagggtccac cagcaggttc tggggcttga tgtcgcggtg acacacgccc tgggagtgga   1380
 tgtaggccaa gctgcggaag agctggtaca tgtacacctt gacatagagg atagggatgg   1440
 tcaacttggc cttggtgaag tggcgggcca cccggtacac tgtctcgggc acatattcca   1500
 gcaccagatt taggtaaagc tcgtctttct tctcgccact ggagtagaaa aagtatctca   1560
 gcctcacaat attgcagtgg tccagcttac gcatgatctg cagctctcgg ttcttgaacc   1620
 tcttgtcctg gagaaccttc ttgatggcga ctagttccct ggtctctgcc agccgtgcct   1680
 ggtacacgac cccaaatgag ccattgccaa tcactttgat gtccgtgtaa gccacttctt   1740
 gggagcgctc tgggccttgg cctagagtgg ctacgactgt ggtcaccttc ccgctgtcac   1800
 ggcccagctt caccccgggc ggcgggaagc tagtgcctgc gccggggcct ccgctgcctc   1860
 ctccgccgct gccgccgggt ccacccccgg agctcgaggc cccgacgccc ccacccatgg   1920
 ccccgacaga tgcctttccg ccgccggtgc cgcctgggcc ggaggccgag cctccggggc   1980
 cgccgccgcc tcctccgcct ccgccgccgg gctccgcgaa cgagctagtc cgcgccctgc   2040
 ccgagccccc agggccgcct cccgaaggcc cgccgccgct catggcgccg agcacaggcc   2100
 caggctgcgg ggctcgggct gcccgggctg ccccagccgc cgccgcggcc gccgcctccc   2160
 ccggagccca agcc                                                     2174



      <210> 1330
      <211> 952
      <212> DNA
      <213> Homo sapiens


      <400> 1330
 tttttttttt ttgggagaga caggtgggat ttattgatgt tgcttttgtg agaacaaatt     60
 tatagcctgg ggaagcatct tccaagggga atatcgcatg gctggaaagg tcacacgcca    120
 gctttgatgt cgggtggcag gaatgtgggc aggaggcagc gctgccagct gcctgtttgg    180
 caaaccccac aggctaccct gctggccagg ccttttccca gcaccttgcc tgtaggacgc    240
 cgggtggcat gcacactatt gtcccaggga ggagaggcag ggactcccca ggtgctgccc    300
 cttcccacaa ccagtgtccc cactggacac ttccaaggcc ccgcagttgc actgcagttc    360
 ctgccccttc tgcacaggct gggagactcc cagagatctt gtttgaatca actccaaatc    420
 cttcaggtcc ttccctgcct cttatcagag gccgctggaa acacaaggcc tgcttctgtg    480
 gaccaggggc tcctctgggg gtggcctcag ccacggctga gatccctaga agtccaggag    540
 cagctgcgga agcaccttct ccagctggtc cacgtccaca cggagcgcgt cttctgcctg    600
 ggcctgccgc acgccgcgga ctgctgcttc cacaacgaag accttcagca actccaccat    660
 gagctgcagc gcgtccccgc tcactttggt cttgtcatcc ttgaagtgca ggtgcagcag    720
 cctgctcacc agctccagct gcgagacacc agcccacgag ggcgcggggc gcgcggcccg    780
 gccggagatg gagtctgaga acgggcccaa cctcaaaggc acagggggcg gcgcgggggc    840
 tggcgtctgg ccctcacagt gtcacgcgtg aggtcgggac ggagcgtccg cgcctgccta    900
 gcccctgccc tccggccctc accttccgga agccggatcc agctcctgct cc            952



      <210> 1331
      <211> 1380
      <212> DNA
      <213> Homo sapiens


      <400> 1331
 tatatcaaca ttgatataga tccagggtac ttaaaaacag ccttaggcct ttatagaagc     60
 tgcctgctca ccgaaaataa gatccgctcc ctaatataca atgccttgaa tcccatgcat    120
 aaagagattt cccagaggtc cacagccaca atgtatataa ttggaggcta ttactggcat    180
 cctttatcag aggttcacat atgggatcct ttgacaaatg tttggattca gggagcagaa    240
 ataccagatt ataccaggga gagctatggt gttacatgtt taggacccaa catttatgta    300
 actgggggct acaggacgga taacatagaa gctcttgaca cagtgtggat ctataacagt    360
 gaaagtgatg aatggacaga aggtttgcca atgctcaatg ccaggtatta ccactgtgca    420
 gtcaccttgg gtggctgtgt ctatgcttta ggtggttaca gaaaaggggc tccagcagaa    480
 gaggctgagt tctatgatcc tttaaaagag aagtggattc ctattgcaaa catgattaaa    540
 ggtgtgggaa atgctactgc ctgtgtctta catgatgtta tctacgtcat tggtggccac    600
 tgtggctaca gaggaagctg cacctatgac aaagttcaga gctacaattc cgatatcatc    660
 gaatggagcc tcatcacctt cagtccacat ccagaatatg gattgtgctc agttccgttt    720
 gaaaataagc tctatctagt cggtggacaa actacaatca cagaatgcta tgaccctgaa    780
 caaaatgaat ggagagagat agctcccatg atggaaagga ggatggagtg cggtgccgtc    840
 atcatgaatg gatgtattta tgtcactgga ggatactcct actcaaaggg aacgtatctt    900
 cagagcattg agaaatatga tccagatctt aataagtggg aaatagtggg taatcttccc    960
 agtgccatgc ggtctcatgg gtgtgtttgt gtgtataatg tctaattgaa tctgcagaaa   1020
 tgaccaagca atcacttttt tggagtatag ttttataaaa aaagaatgca gggtttgaag   1080
 ttccttacct gataattgtg tctggcacat gataggggat cagtaaattg taattcctaa   1140
 ccctactgta ctcccaaaca tggtgattca tggtcaagaa aaatcttata tatatatatg   1200
 tacacacata tatatgtgtt catatatatg tatacatata tgtgtatata tacgcatgta   1260
 tgtatacata tatgtgtata tatgcgcatg tatgtatgca tatgtgtgta tatatgcgta   1320
 tgtatgtata catgtgtgta tatatacgta tgtatgtatg catatgtgtg tgtatatacc   1380



      <210> 1332
      <211> 906
      <212> DNA
      <213> Homo sapiens


      <400> 1332
 atggtaaaaa taatcaaacc caaggcgatt cagattggca cagcttccat accagggcag     60
 gtgggcccgg caaccagtac cgatattgca ccgccagata tcccggctgg cttcgtggct    120
 gttttcaaca gtgatgagtc atcgtggcat ctcgttgaag atcatcgggg taaaacggtt    180
 tatgacgtgg cttccggcaa cgcgttattt atttctgaac tcggtccgtt accggaaaat    240
 gttacctggt tatcgccgga aggggagttt cagaagtgga acggcacagc ctgggtgaag    300
 gatacggaag cagaaaaact gttccggatc cgggaggcgg aagaaacaaa aaacaacctg    360
 atgcaggtag ccagtgagca tattgcgccg cttcaggatg ctgcagatct ggaaattgca    420
 acggaggaag aaatctcgtt gctggaagca tggaaaaagt atcgggtatt gctgaaccgt    480
 gttgatacgt caactgcaca ggatattgaa tggccagcac tgccgattat tcaagaagtg    540
 ctgccagcac tcgaaaatgt gattgctgtg atggtggcgg atttacagag gcgcaagtgt    600
 ttaccaacaa ggtctcatac ccatggggga aaccgcctta ctggtcgaaa atgtcgcgtg    660
 ccgttcgccc aagcgactgg gagagctgga cacaggcgca cagaatcgcc agtcactatg    720
 gcgtgctgta gcgctatatg cgatgatgca aaatctatgc gaacccgaac acgcaacata    780
 aaacaagtac aacaaccgcc gccaagtcct gcaacgtcgc tacttggagc cactatcgac    840
 tacgcgatca tggcgaccac acccgtcctg tggatctacc cactagtcaa ttcaccatct    900
 tgttga                                                               906



      <210> 1333
      <211> 2756
      <212> DNA
      <213> Homo sapiens


      <400> 1333
 tttttttttt ttcatgttcc cgtatgcttt attggaatgc tgtcaggtcc gcgccttcca     60
 cctgggccct cacacacagc aaggagaggc cccagcaccg gtcccaggcc cacctgcccg    120
 cacctgcaga agggaaaggc catcaccctc cgtggacggg gtctcggcca ccacatccac    180
 cttctgaagg tggcccagac acctccacgc tgctgactgc acttcccatc aaaagggact    240
 ccctggggca gagtgggccg tccccctacc cccgaggaag gcaccctcct gggcggggac    300
 agaccttggc tccatgctgc caagtcaagg tgctggcgtg gaaacaggca catgtggaac    360
 accacatccc actgtccaag gtggagtcca cccctcctcg gagcactcag cccaccaggg    420
 tccaagcagc cctcgggaga taccacgcgg ccgcccacgt ctcagcttgg agaaagacac    480
 tcaaagaccc ccacgctcag ctctcggggg ctggcttcct gggccctttg tgctggctgc    540
 tttcccggtg gcttctcagc accttgagcc tctgatgccc cgcctctgac ctcaggtcca    600
 actacagcag gtggctgctt cggtgatcaa atccctccgt ggcagccaag gacaccggcc    660
 ctccacacca gctaccaaga gggctggtgc ccacagggag gaccgggcgc caggagggct    720
 cgctgaaatc tcggtcccat cctgttctgc aagtggctga gtccctaggg tgggacgagc    780
 acaggggctg aagggcccag gctgctccag gagtgctgca gacggcgacc gggaagtggg    840
 gtgaccaggg agcatggcca aggccagagt gatgagcatg gtggcaggga ggagagcacc    900
 tcacgtacaa actgcacgag cttcgggcgc atgcatggct ggccaagact gagggtcaca    960
 cagggcagac aagggagacg agtcacacgt ggcagcacat catccagtcc tcggggaggt   1020
 gagggttggc atgtggcggg caccggtgtg cagggcagcc ccatcctggg gctggagctt   1080
 ccctagaccc aggcaccacg cacaggcatc ccctgctcag ctcctgaacc cggcccctcc   1140
 tgcctggcca cgtccgctat cgcaccctcc tgcatcaggg ccgagggccc accctgcgct   1200
 cctttttctt ccagggtgtt ccaggatggt caagttccag cactgagaac agctcaggtg   1260
 tgggtgtggc tattgtggag gccgtgtctg gtgaacctgg tgaacttggt ggtgggacgg   1320
 tgctgatgca ggggagccac agagggttac gaccgacgcg ggtctgacag cacaggccca   1380
 ggcaggcgtg gactcgggag ccgagggtgg tcggatggca gcgtgagcgc cagtatcatt   1440
 tccagcattt ccatctttac cactccagtc actctcttca aaaagaaaga actagagcaa   1500
 aaccaaagtt aaatatctca acgagaaggg acacctcacg tcgctgacag ctcggcacgt   1560
 ggctggtccc aggccccaga gatactgcgt agtgaactgg ccgctggaac gcagtcacag   1620
 gcctctgtgc tgcagcccac ctcccagcaa gccacgcaga gccccggcct tgagtccaag   1680
 aatgcccagg ggagtgtggg acgggacggc ccccacacag gctggacagc aagccgcccc   1740
 cacgcaccga agactcccca cgcgcaggcg gcgcacaccc gggtctccct agggtcctgc   1800
 ctcccgagac gctgtcctca cactgcagtt gctgattctt gggtcaaatg gaaggaggag   1860
 gaacgacgag ggcagagtgc aaacacgaag tcgcccgggg gcgctgggga cgggggcgca   1920
 gtgggcccta ccagttctgg ttgtcccagc catcatcagt gggcacggcc ggcggcactg   1980
 ccttcttggt gccctccccg ccctccccgc cgtcgctgtt gctgttcctg ttggtggagg   2040
 ccgagcccca cacctcccag ctgtccgagc tcctcctctc ggtggaggtg tccgcgcacg   2100
 tccagctgtc gctgctcggg gacttgcggg tcttggtggg ctcagcactt ccaaaggtct   2160
 cccagaagct ctggtctatg ttgctgtttt ggaagtggtc cagaccgctg ttctgataac   2220
 tgtggccctc cgaggggctg tccaaggggc cctctgcttt ccccgaaaaa aaggtggtga   2280
 cgtcccgcca tcccttacta ccgactccct ggaccttgga cgccaactga gagaccccac   2340
 tggagacatc atcaaaaatc tttccctcct tcaccttctc ctgcgcaggc ttgaggacgt   2400
 tctcgttcag gctgtggccc agctcggacg ccttctgact cgcttgggat ccaaactttg   2460
 tagcgccctc cttggctgcc gaggcaaacc ggctggctcc agtggtgaag ctgctccagc   2520
 ccgagtacag ggaggacatg gcgttgttga ggaagtcatc ttctttcttc tgaggcggtg   2580
 gcgtgttccc aaaccccacg tagcgattcc cctgggcccc ttgataggag ccgaggtcat   2640
 cattcagcca gtcttcaaaa gccttgtccg aggaggcggt cacactctgc ggctggccag   2700
 agactcggtg caccatgaaa ggcagcgtcc tgcccacgcg tccgcccacg cgtccg       2756



      <210> 1334
      <211> 384
      <212> DNA
      <213> Homo sapiens


      <400> 1334
 tttcgtgagc agacagcgag ctttggaatg tgaatgagaa gatgtagtgt gacagcagcc     60
 cgggtgacac ctgctgggag cttggcgtgg acaccccagc cacccccagc ccagcccagc    120
 cggagcaccc tacccctggg catccccctg gccatccagc ctcaccatgt ccaagagggg    180
 catgagcagc cgggccaagg gggacaaggc agaggccctc gcggcgctgc aggcggccaa    240
 cgaggatctt cgagccaagc tcacagacat ccagatcgag ctgcagcagg agaagagcaa    300
 ggtcagcaaa gtggaacgcg agaagaacca ggagctgcgg caggtgcgcg agcatgagca    360
 gcataagacc gcggtcttgc tcac                                           384



      <210> 1335
      <211> 471
      <212> DNA
      <213> Homo sapiens


      <400> 1335
 tttcgtacag aagtgcagcg gtggcggcgg ctggttgcgg gccggcggcg ggctggcgga     60
 gatggaggat cttgttcaag atggggtggc ttcaccagct acccctggga ccgggaaatc    120
 taagctggaa acattgccca aagaagacct catcaagttt gccaagaaac agatgatgct    180
 aatacagaaa gctaaatcaa ggtgtacaga attggagaaa gaaattgaag aactcagatc    240
 aaaacctgtt actgaaggaa ctggtgatat tattaaggca ttaactgaac gtctggatgc    300
 tcttcttctg gaaaaagcag agactgagca acagtgtctt tctctgaaaa aggaaaatat    360
 aaaaatgaag caagaggttg aggattctgt aacaaagatg ggagatgcac ataaggagtt    420
 gggacaatca catataaact atgtgaaaga aattgaaaat ttgaaaaatg a             471



      <210> 1336
      <211> 2454
      <212> DNA
      <213> Homo sapiens


      <400> 1336
 ggcacgaggg cactctcagc agtaggcgca accgtgctca ccccgtgcct aacagccttg     60
 cttagtccgg gctccgaggc agcagcagcc ataagaaaaa acaggagagg aaggcgatgt    120
 ggcgcttctg ccgggccctc agactgggga gtgtgaggaa acctgtagga agtgtcaggg    180
 actctggaaa gaacataatg gcctcacctg tgaagagctg gctgaaaaag acgacatcaa    240
 gtaccgtacc tctattgaag aaaaaatgac tgctgcccgc attagaaaat gccacaagtg    300
 tgggactggc ctcatcaaat ctgaaggctg caaccgcatg tcttgccgct gtggtgccca    360
 gatgtgctac ctctgtcgag tttctattaa tggatatgac catttctgcc aacatccccg    420
 ctcaccagga gccccttgcc aggagtgttc aagatgctct ctctggaccg atcccactga    480
 agatgatgag aagcttattg aggaaatcca gaaggaggct gaagaggaac agaaaagaaa    540
 gaatggagag aacaccttca aacgcattgg acccccgctg gagaagcctg tggagaaggt    600
 gcagagggtg gaggccctcc cgaggcccgt tccgcagaac ctgccacagc cacagatgcc    660
 accctatgcc ttcgcgcacc cacccttccc cctgcctccc gtgcggcctg tgttcaacaa    720
 cttcccactc aacatggggc ctatcccagc cccgtacgtg ccccctctgc ccaacgtgcg    780
 ggtcaactat gacttcggtc ccatccacat gcccctggag cacaacctgc ccatgcactt    840
 tggcccccag ccgcggcatc gcttctgatg gccccgaatc cccattgagc agcacaaagc    900
 ccgtttgggg taggagtgtg gatggagaac cctcccccaa ggctggtgtc tgtaccattg    960
 catcctaagt cagcttgaag ggtaggctgg ttttcttccc acccctttcc tagaagggct   1020
 actgctcctg gaagagtgga cggatccata ataaagacgt cccaaatggt ggagttcgga   1080
 gagagctgcg atgtgaactg gccctcccct cgcatccccc aggccaccaa cggcagtcct   1140
 tctgccttgt ccatggcata ggccatagac caggtccctg ctgctcacac ctgggcctct   1200
 cctcggagcc gacccctggg tagcaaggca gccgagagca tctccctgga ggggcccacg   1260
 gttgggccaa gggcagaggg ggctgcacct gcgggcctgg gaagcattgc tcagggtggg   1320
 gggctgggac catggcccgc agaggcactg ccacagctgt gagggccaag atgctgtccc   1380
 cccatccaaa acccgtgcgc cactgcagtg agtgttgagg gcacctctcc tcccctctta   1440
 cacctactca gatgaggcag cagcagaccc atctcgcggc gggggttttg ttctgttgcc   1500
 gcctaacttt ctcatcctcg gtctctggaa agtcaggctg agaaatcctt tcccaggcca   1560
 ggccgctgcg gtacactgga tggttctgaa gctggcccat tgaaagagcc tcttaaggca   1620
 gctgggacag aggcctggtg gccctgctgg gcagcccaac tgctggggga gacgtttctg   1680
 ccaccctggg tgatgagcag cttttccccc ctggctttct gggggaggag tgggcctcct   1740
 tagggagaca ggtgaccctg ggtgccaccc ctgccccgtg tgtgccccgg gtgttctcag   1800
 tggttgctga aggcaggtag agggtgctgt ccagtatccc ccatgtgaag gtcacttccc   1860
 ttctcatgga gtcagctgag catcagctca gccctgccat gtccccactc accctcctcg   1920
 cctcctgtcc ggccctgggt ttctagccgt gcctgaggca tcactctggc ccattgacag   1980
 atgagaggtc tgaagccttc ctggccacag gcatcacttt ctcctcctcc tcatgccctg   2040
 ccttgtcctt gtcgtgttgc catggggttc tgagaggctg ggagttcaca gacctcagac   2100
 acagctgagt ccgacaacca ttggggttgg ggctgcatca gtctccggag tggcccgcca   2160
 cctcctgaag cagggcctgg cccacccaag gtgcctgggg gcaggcgggg caccgtcatt   2220
 cggttgccat tggtttctca gatgtatttc aaggactaaa gtgggctcta agatctaaga   2280
 tggcccggcg cggtggctcc cgccttgtaa tcccaagcac tttgggaggc cgaaggcggg   2340
 cggaatgagt ttgaggtcgg gaattttgag tcccccgtct ctaactaaaa aatacaaaat   2400
 ttagccggac aaaggtgggc gcatgcctaa taaatcccag gtacttcaag gagg         2454



      <210> 1337
      <211> 1730
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1730)
      <223> n = a,t,c or g


      <400> 1337
 catcgaacgc ctagaggtac cgttgcagaa ttcccgggtt aatgctcact ttaaccagct     60
 atttcttaga ccaaataaag agaaaataga ctttcttctt gaggtatgtt caagatcagt    120
 aaatttagaa aaagcttcag agtctttgaa aggaaacatg gctgcttttc taaagaatgt    180
 gtgtctgggg ttggaagatc tgcagtatgt tttcatgatt tcttcacatg agcttttcat    240
 tacattgttg aaagatgaag aacgaaagct acttgttgat cagatgagga agagatcccc    300
 tagagtaaat ctgtgcatta aacctgtaac ttcattttat gatatcccag cttcagcaag    360
 tgtcaacatt ggtcagttag agcatcaact tatattgtca gtggatcctt ggaggattag    420
 acaaatttta attgaattac atggtatgac ttcagagcgc cagttctgga cagtgtctaa    480
 taagtgggaa gtaccttctg tctatagtgg tgttatcctg ggaattaaag acaatttaac    540
 aaagagattt ggtttatatt cttatggcca aaggtttgca ctgcagtact gttaaggact    600
 tttcccatgc taaacagctc tttgctgctt gtttggagtt ggtaacagag ttctcaccga    660
 agcttcgtca ggtcatgctg aatgagatgt tgcttttgga tattcataca cacgaagctg    720
 ggacagggca ggcaggagag agaccgccat ccgaccttat aagtagagta cgaggctatc    780
 tggaaatgag gccttcctga tatttctctt cggcaaggta taactgagga atgtgtcgcc    840
 tttatgttaa actggagaga aaatgaatac cttacactcc aagttcctgc atttttgctt    900
 cagagtaatc catatgtaaa gcttggacag cttttagcag ctacatgcaa agaacttcca    960
 ggccctaaag aaagcagacg gactgccaaa gacctttggg aagttgttgt tcaaatctgt   1020
 agtgtgtcca gtcagcacaa acgaggaaat gatggcagag ttagtttaat aaaacagagg   1080
 gaatctacgt taggtatcat gtatcggagt gaactgcttt cttttatcaa aaaattacga   1140
 gaaccactcg ttttgactat tattttatca ctctttgtga aacttcacaa tgttcgggag   1200
 gacattgtga atgatattac agctgaacac atttctattt ggccatcttc cattcccaac   1260
 ctccagtctg tggactttga agctgtggca atcacagtga aagagctagt tcgatataca   1320
 ctcagtataa atccaaataa ccattcttgg ttaattatcc aggcagatat ttactttgca   1380
 acgaatcagt attcagcagc tcttcactat tacctccagg caggagctgt gttgttctga   1440
 cttctttaac aaggctgtgc cccctgatgt ttatacagac caggtaataa aacgaatgat   1500
 aaaaatgttg ttctttgctg aattgccaca cacaggtggc taattttatg tcagttcctc   1560
 agaggaaatt gacctacaaa acagcggttt aaaatctctg gcaaggacca aaacagtcca   1620
 tgatggctat gggactccta ctacgactta catatnggga tggttancat tttgggaata   1680
 cctgggctta tcttccatcn taaaaggggg gggaacnggg taaaggccaa              1730



      <210> 1338
      <211> 1784
      <212> DNA
      <213> Homo sapiens


      <400> 1338
 ccagctgcca ggcaccttgt aaatacatgg tgccgggcag ctggccatga ctcatccaag     60
 tcatcattta aattttggaa tgaatcctga tcatgccagg aattcattat ctaactgtgg    120
 aattcggcag cccaaatacg gagacagaaa agttcatcac atgcacatgc ggaagaaagg    180
 gattaacacc ttgataaata tcatgtcacg ccttggccaa gatgacccaa ctccctcgag    240
 gattaaccac aatgaacggt tggaattcct gggtgatgct gttgttgaat ttctgaccag    300
 cgtccatttg tactatttgt ttcctagtct ggaagaagga ggattagcaa cctatcggac    360
 tgccattgtt cagaatcagc accttgccat gctagcaaag aaacttgaac tggatcgatt    420
 tatgctgtat gctcacgggc ctgacctttg tagagaatcg gaccttcgac atgcaatggc    480
 caattgtttt gaagcgttaa taggagctgt ttacttggag ggaagcctgg aggaagccaa    540
 gcagttattt ggacgcttgc tctttaatga tccggacctg cgcgaagtct ggctcaatta    600
 tcctctccac ccactccaac tacaagagcc aaatactgat cgacaactta ttgaaacttc    660
 tccggttcta caaaaactta ctgagtttga agaagcaatt ggagtaattt ttactcatgt    720
 tcgacttctg gcaagggcat tcacattgag aactgtggga tttaaccatc tgaccctagg    780
 ccacaatcag agaatggaat tcctaggtga ctccataatg caactggtag ccacagagta    840
 cttattcatt catttcccag atcatcatga aggacactta actttgttgc gaagctcttt    900
 ggtgaataat agaactcagg ccaaggtagc ggaggagctg ggcatgcagg agtacgccat    960
 aaccaacgac aagaccaaga ggcctgtggc gcttcgcacc aagaccttgg cggacctttt   1020
 ggaatcattt attgcagcgc tgtacattga taaggatttg gaatatgttc atactttcat   1080
 gaatgtctgc ttctttccac gattgaaaga gttcattttg aatcaggatt ggaatgaccc   1140
 caaatcccag cttcagcagt gttgcttgac acttaggaca gaaggaaaag agccagacat   1200
 tcctctgtac aagactctgc agacagtggg cccatcccat gcccgaacct acactgtggc   1260
 tgtttatttc aagggagaaa gaataggctg tgggaaagga ccaagtattc agcaagcgga   1320
 aatgggagca gcaatggatg cgcttgaaaa atataatttt ccccagatgg cccatcagaa   1380
 gcggttcatc gaacggaagt acagacaaga gttaaaagaa atgaggtggg aaagagagca   1440
 tcaagagaga gagccagatg agactgaaga catcaagaaa taaaggaggg catgcaagtg   1500
 tggagtattt acttgctcag taactgtgac tgttgtctat tgagacctag cctagttttc   1560
 ctgcagacaa tgaacgaagt gtgctcattg aaataaaata cagagtcaaa tcgctattgt   1620
 tgttttaatg atctgttttt agctggatgg tctttattac aaagtattag atttttcttc   1680
 tatttaacgg aaaacttgac tttggtgaat gtgcattact tccttttatt ttgctcttta   1740
 aataataaaa ttcaagaagc atattctatg tggaaaaaaa aaaa                    1784



      <210> 1339
      <211> 2297
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2297)
      <223> n = a,t,c or g


      <400> 1339
 gttttaatgn tcttaaccgt ctatgccgag aaatcnttgg ggagggccca taaggcaccc     60
 tccactnttg nctgaggaga tacgaaagca gaagtaatgg gatctgtact tggggcacag    120
 agagggtttc agaggatcct tgtgaaacac tagttaaaag atgacgagta gctccgaaca    180
 ggaagaggac gaaaaaaata accagtccgc gacgccgaga caaaccggac ccgcaaccac    240
 catgaacagc aaaggtcaat atccaacaca gccaacctac cctgtgcagc ctcctgggaa    300
 tccagtatac cctcagacct tgcatcttcc tcaggctcca ccctataccg atgctccacc    360
 tgcctactca gagctctatc gtccgagctt tgtgcaccca ggggctgcca cagtccccac    420
 catgtcagcc gcatttcctg gaagcctctc tgtatcttcc catggcccaa gtctgtggct    480
 gttgggcctt taaggttcca caatccccat ggcttattat ccagtcggtc ccatctatcc    540
 accttggctc cacaagtgct tggtgggaaa ggagggtatg atgcaggtgc cagatttgga    600
 gctggggcta ctgctggcaa cattcctcct ccacctcctg ggatgccctc ccaatgctgc    660
 tcagcttgca gtcatgcagg gagccaacgt cctcgtaact cagcaggaag gggaacttct    720
 tcatgggtgg ttcagatggt ggctacaccc atctggtgag gaaccaaggc cacctttgtg    780
 cccgggaaaa gacatcacat acccttcagc acttctcaca atgtaactgc tttagtcata    840
 ttaacctgaa gttgcagttt agacacatgt tgttggggtg tctttctggt gcccaaactt    900
 tcaggcactt ttcaaattta ataaggaacc atgtaatggt agcagtacct ccctaaagca    960
 ttttgaggta ggggaggtat ccattcataa aatgaatgtg ggtgaagccg ccctaaggat   1020
 tttcctttaa tttctctgga gtaatactgt accatactgg tctttgcttt tagtaataaa   1080
 acatcaaatt aggtttggag ggaactttga tcttcctaag aattaaagtt gccaaattat   1140
 tctgattggt ctttaatctc ctttaagtct ttgatatata ttacttgtta taaatggaac   1200
 gcattagttg tctgcccttt tcctttccat cccttgcccc acccatccca tctccaaccc   1260
 tagtcttcca tttcctcccg ccagtctcca attgaaatca atgggtgcag gacagaaagc   1320
 caggncagga ctaatttcct tctttcctcg cacttctccc cactcgtcat cttttaacta   1380
 gtgtttcaca aggatcctct gaaaccctct ctgtgcccca agtcacagat gcccattaac   1440
 ttctgctttc gtatctcctc agggcaaaag tgggaggggt gccttatggg gccctcctca   1500
 taggttgtct ctgcatacac gaacctaacc caaatttgct ttggtgccag aaaaactggg   1560
 cctatgtttg gaaccaagga tgtcgtccaa cctgtactgt gaaccaacca gtggggttta   1620
 aaaatatgag gggccaagga ggaggatgcc attccaaaaa gctggatgga tgtgttcaga   1680
 gcctaaatta agaggagttt tcagatccaa aaactgggtt acccattttt tgtccagagt   1740
 gtctggatgc cggcccactc aattcgggct cccccagaat tccttagact tgggttaata   1800
 gggtccatat tggtgaatgt ctcactacca aaatgacctg gagtccagtg aaatctccat   1860
 taggggttta agaatatttc agggatccct taatgttttg aatttttgtt ttctgaaatt   1920
 gggattttat tttattttaa tcttataatt tcagttcatc taaattgtgt gttctgtacc   1980
 atgtgatgtt tgactgtacc atttgactgg taatggaagt tcagcgttgg tatgtctctt   2040
 ctctacactg gtggtgcacc ttaacttggt ggaattttta tactaaaaaa tgtagaataa   2100
 agactatttt gaagatttga ataaagtgat gaagttgcat tacacctcac tgcaaggatt   2160
 ctttacttag cttgttttta gatttcttct atatatattt tatttatatc ccatctagaa   2220
 ttcagctagg tgctgctgct gctctgtttc ctttgatgac gctttgaaat aaaggcagga   2280
 gtacaagcct aaaaaaa                                                  2297



      <210> 1340
      <211> 2297
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2297)
      <223> n = a,t,c or g


      <400> 1340
 gttttaatgn tcttaaccgt ctatgccgag aaatcnttgg ggagggccca taaggcaccc     60
 tccactnttg nctgaggaga tacgaaagca gaagtaatgg gatctgtact tggggcacag    120
 agagggtttc agaggatcct tgtgaaacac tagttaaaag atgacgagta gctccgaaca    180
 ggaagaggac gaaaaaaata accagtccgc gacgccgaga caaaccggac ccgcaaccac    240
 catgaacagc aaaggtcaat atccaacaca gccaacctac cctgtgcagc ctcctgggaa    300
 tccagtatac cctcagacct tgcatcttcc tcaggctcca ccctataccg atgctccacc    360
 tgcctactca gagctctatc gtccgagctt tgtgcaccca ggggctgcca cagtccccac    420
 catgtcagcc gcatttcctg gaagcctctc tgtatcttcc catggcccaa gtctgtggct    480
 gttgggcctt taaggttcca caatccccat ggcttattat ccagtcggtc ccatctatcc    540
 accttggctc cacaagtgct tggtgggaaa ggagggtatg atgcaggtgc cagatttgga    600
 gctggggcta ctgctggcaa cattcctcct ccacctcctg ggatgccctc ccaatgctgc    660
 tcagcttgca gtcatgcagg gagccaacgt cctcgtaact cagcaggaag gggaacttct    720
 tcatgggtgg ttcagatggt ggctacaccc atctggtgag gaaccaaggc cacctttgtg    780
 cccgggaaaa gacatcacat acccttcagc acttctcaca atgtaactgc tttagtcata    840
 ttaacctgaa gttgcagttt agacacatgt tgttggggtg tctttctggt gcccaaactt    900
 tcaggcactt ttcaaattta ataaggaacc atgtaatggt agcagtacct ccctaaagca    960
 ttttgaggta ggggaggtat ccattcataa aatgaatgtg ggtgaagccg ccctaaggat   1020
 tttcctttaa tttctctgga gtaatactgt accatactgg tctttgcttt tagtaataaa   1080
 acatcaaatt aggtttggag ggaactttga tcttcctaag aattaaagtt gccaaattat   1140
 tctgattggt ctttaatctc ctttaagtct ttgatatata ttacttgtta taaatggaac   1200
 gcattagttg tctgcccttt tcctttccat cccttgcccc acccatccca tctccaaccc   1260
 tagtcttcca tttcctcccg ccagtctcca attgaaatca atgggtgcag gacagaaagc   1320
 caggncagga ctaatttcct tctttcctcg cacttctccc cactcgtcat cttttaacta   1380
 gtgtttcaca aggatcctct gaaaccctct ctgtgcccca agtcacagat gcccattaac   1440
 ttctgctttc gtatctcctc agggcaaaag tgggaggggt gccttatggg gccctcctca   1500
 taggttgtct ctgcatacac gaacctaacc caaatttgct ttggtgccag aaaaactggg   1560
 cctatgtttg gaaccaagga tgtcgtccaa cctgtactgt gaaccaacca gtggggttta   1620
 aaaatatgag gggccaagga ggaggatgcc attccaaaaa gctggatgga tgtgttcaga   1680
 gcctaaatta agaggagttt tcagatccaa aaactgggtt acccattttt tgtccagagt   1740
 gtctggatgc cggcccactc aattcgggct cccccagaat tccttagact tgggttaata   1800
 gggtccatat tggtgaatgt ctcactacca aaatgacctg gagtccagtg aaatctccat   1860
 taggggttta agaatatttc agggatccct taatgttttg aatttttgtt ttctgaaatt   1920
 gggattttat tttattttaa tcttataatt tcagttcatc taaattgtgt gttctgtacc   1980
 atgtgatgtt tgactgtacc atttgactgg taatggaagt tcagcgttgg tatgtctctt   2040
 ctctacactg gtggtgcacc ttaacttggt ggaattttta tactaaaaaa tgtagaataa   2100
 agactatttt gaagatttga ataaagtgat gaagttgcat tacacctcac tgcaaggatt   2160
 ctttacttag cttgttttta gatttcttct atatatattt tatttatatc ccatctagaa   2220
 ttcagctagg tgctgctgct gctctgtttc ctttgatgac gctttgaaat aaaggcagga   2280
 gtacaagcct aaaaaaa                                                  2297



      <210> 1341
      <211> 368
      <212> DNA
      <213> Homo sapiens


      <400> 1341
 gatcctgctt gtttccaaac tgtccttggc tccttgagtg cactgaaatt gttcatctgt     60
 gttctgtttt ccagggtcac aaagagtcgg cagcattctt gggaaatctt ggtagggttg    120
 ggtagttgcc actggtgtct ggcttctgaa ccccctgaaa gctgtaggac aggaggaata    180
 tagtttaaag atggagggcc cacggccaga ggtaacttgt aggcatttgt aaactctctt    240
 gaagtggccc ataaagacat gcgctcttcc tgttccttct gtttcatctc gacttcatct    300
 aatatctgct cgatattcct cagcctatca tcattctcgt gcattattgt ctgcataatc    360
 tttagatc                                                             368



      <210> 1342
      <211> 5421
      <212> DNA
      <213> Homo sapiens


      <400> 1342
 ctgctctgcc ggggaaggag gaggagagca gatgagtgag ctgccctctc tggagagggg     60
 acagggcagg gcctcggcaa gctccactgg tgatctcgcg taggtctcct tcatccagac    120
 gcacagctgg aggatcgtgg gagcaggaag gggacaggtg gcccatctgg tgacactgct    180
 cctctcagcc tgaatgggct cctggcccct tggaccctcg cagagctctt gcccagaacg    240
 ttgcccactc cttcctcctc ctgtcagctc cggggcttgc agagggggca gcctggctga    300
 ggagagctgc gggtgctggc cctggcccac ggcgagctgg catgccatgc cgtcctgacc    360
 gcctccctcc tctccctcag gtcccgttta atggattctg acatggatta tgaaaggcca    420
 aacgtagaga ccatcaagtg cgttgtggtg ggggacaacg ccgtgggtaa gaccaggctc    480
 atctgtgccc gcgcttgcaa tgccaccctc acccagtacc agctgctggc cacgcatgtg    540
 cccacagtat gggccatcga ccaatatcgt gtgtgccagg aggtgctgga acgctcccga    600
 gacgtggtag atgatgtcag cgtctctctg cgcctctggg acacctttgg agaccaccac    660
 aaagaccgtc gctttgctta tgggagatct gatgtggtgg ttctgtgctt ctccattgcc    720
 aaccccaatt ccctccacca tgtcaagacc atgtggtacc cagaaatcaa gcacttctgc    780
 ccccgagcac ctgtcatctt ggtgggctgc cagttggacc tgcgctacgc tgacctggag    840
 gctgtcaaca gggctaggcg acccttggct aggcccatca aacctaatga aatcctgccc    900
 ccagagaagg gtcgggaggt ggccaaggag ctgggcatcc cctactatga gaccagcgtg    960
 gtggcccagt tcggcatcaa ggacgtcttt gacaacgcca tccgagctgc actcatctcc   1020
 cgccgccacc tgcagttctg gaagtcccac ctccgcaatg tgcagcggcc tctgctgcag   1080
 gcacccttcc taccccccaa gccaccgccc ccgatcatcg tggtgcccga ccctccctcc   1140
 agcagcgagg agtgccccgc ccacctcctg gaggacccgc tctgcgcgga cgtcatcctg   1200
 gtgctgcagg agcgggtgcg catctttgcc cacaagatct acctctccac ctcctcctcc   1260
 aagttctatg acctgttcct catggacctg agtgaggggg agctgggggg cccctcggag   1320
 ccagggggca cccacccaga ggaccaccag ggccactctg atcaacacca ccaccatcac   1380
 caccaccacc atgggcgaga cttcctgctc cgagcagcca gctttgacgt gtgcgagagc   1440
 gtggatgagg ctgggggctc cggtcctgct ggcctccgtg cttccaccag cgacgggatc   1500
 ttacggggca acggaacagg gtacctaccg ggcaggggtc gtgtgctgtc ttcctggagc   1560
 cgagcttttg tgagcatcca ggaagagatg gcagaagatc ctctcaccta caaatcccgg   1620
 ctgatggtgg tggtgaagat ggacagttcc atccagccgg ggcccttccg ggctgtcctc   1680
 aagtacctgt acacggggga gctagatgag aacgagcgtg acctcatgca cattgcccac   1740
 attgctgagc tgctcgaggt ctttgatctg cgcatgatgg tggccaacat tctcaacaat   1800
 gaggccttca tgaaccagga gatcaccaag gccttccacg tccgccggac caaccgggtt   1860
 aaggagtgct tggcaaaagg caccttctca gatgtgacct tcatcctgga tgatggcacc   1920
 atcagcgccc acaagcccct gttgatttcc agctgtgact ggatggctgc catgtttggg   1980
 gggccatttg tggagagctc cacccgggag gtggtgtttc cctacacaag caagagctgc   2040
 atgcgggccg tgctggaata cctctacacc ggcatgttca cctccagccc cgacctggat   2100
 gacatgaagc tcatcattct agccaaccgc ctctgcctgc cacacctggt tgccctcaca   2160
 gagcagtaca cagtgaccgg gctgatggaa gcgacccaga tgatggtgga catcgatggg   2220
 gacgtccttg tgttcctgga actggctcag ttccactgtg cgtaccagct ggccgactgg   2280
 tgtctccacc acatctgcac caactacaac aacgtgtgcc gcaagttccc ccgagacatg   2340
 aaggccatgt ccccagaaaa ccaggagtat ttcgagaagc atcggtggcc acctgtgtgg   2400
 tacctgaagg aggaagatca ttaccagcgg gcacggaagg agcgtgagaa ggaggactac   2460
 ctccacctca agcggcagcc caaacggcgt tggctcttct ggaacagtcc atcctccccg   2520
 tcttcctcgg cagcctcctc ctcatcccca tcttcctcct cggctgtggt ctgagatgct   2580
 gccaccctct tctgaccctg ctgctgttgt ccccatccgc cttcacccct ctgctcttcc   2640
 gcatcacccc atccacctta cagggaccag ggggcccacg taaccaggac ccagagggtg   2700
 gagctcttct taccagccac cgtggctcag ccagagagga gctgagccct gtggagcaga   2760
 acgggaacca cctgcagagg tccccagacc caaagcagga cgggagacaa ctgcttggag   2820
 gagcgaagag ccctggcatt ttatctctgg gtttgagagc cctagagtca aagggaaagc   2880
 ctcccagcct ccagggcttc tctgtgtgtc ttggttgctg ctctggccag ggaggcagcc   2940
 ccactcccag caagcagaag tgatcctcga gggtcctgcc cctgttggcc atatctttcc   3000
 accgacggac ttgagtgttg catttgtttt gtgggcattt ccacacgaag cctactcaca   3060
 ccctcactgg agaagtcagg gtagaaattg agccttcaga gcccaactca aggcttctac   3120
 atcctggggt gcagctgcaa aaggccagac gtggaaaggc ctgtatcctg ccagtgtccc   3180
 tccgtcccag ggggctgtgc tggcacagac ctgagaatgg ggacacaggt cattcagagc   3240
 tccaggcctg gaagcagtgc ctcttggtgc aacaagaaac ttctccctca ccccctcctt   3300
 taccctcaga tttggagatg gtaaccaaag gaagcagctg ggacaggtgg agaaggaagt   3360
 aggaatgagt gcacggcgac cccgtgctcc tcagggccct cccctgcctc tgggtggcac   3420
 tgctttttat aggggggggc aaaattagca aaaaacaaaa accaatgaca accaaactga   3480
 aaccgaaacg aaaaatcaac aaacactctg tcctctatcc ctccaaagaa tgaaaatcag   3540
 aaaaagcccc tgcctagctc acatttctat aaacagaggc ccccatgatg aggaggggaa   3600
 gatttaagtt gctgaatgga ctccaatgcc tttcaggaaa ggactcggca cttctctgac   3660
 tgcggaggcc ctgaccctgc cagctggctc cgagggcaac acaggggcct ggcctctaga   3720
 gggctggtga ttgaggggcc cgggctggcg gcaaagaggg gtttggtctc ggggcttaaa   3780
 tggcaccaga ctcttgcttt tgcccatctg gagactgcag gctcccttcc ttaccctcag   3840
 agagtgctta tggtgggtgt ttttgcgggg ctgcaatagg ggccaaaagt cagggaaagg   3900
 ggcactgacc tgtagtgaaa ggccacagga cacagcctta ttactgcctg gggtgggata   3960
 aggggaagga gaagagcgag aatggagcag gaggaaaagc agagttggtc tagagaggag   4020
 gagggcgggg ctggaggaat gtgggggatt gaaactagct cccagccccc atggggcagc   4080
 agctgggcca caattgcccc tttccgtttt ctaaccccga ctcagatttc accacccaca   4140
 ctctttttag gtgtaaaaga tggagtccca cggaggaggg gcagagccag gaggcagtgg   4200
 ggctgtgggc tcagagctca ggagtcgcct tacctgagag agatgttcta gctgagaggg   4260
 cctggccctg gggtgggctc caggaaaacg ctggttaggc ctgggattga gctaacctga   4320
 aacaaaggta gtaggcagga cctaatgacc agaggttaaa tcctcatcaa gagagaccag   4380
 gcggctggag gacaagcggc tctaaccctg ggggcggcca tgttgtccag gcccaggccc   4440
 ctccaggact gtggctgcct cccctccacg gcctccaggg cggctggctg gaaagccacg   4500
 cgtatgctgc cctctacagg ctgctcggcc tccctgcagc tcagcgcagc ccagggctcc   4560
 aagtgaggcc cagaagccca tgggcagggc tggggggacg aagggggaac ccggagcacc   4620
 tccacttcta gggaagatgg acagcgtggg ggcacacctg ggcctcccgg aagctgtgga   4680
 cgaaagggag agcgggtcct ccagggcaag gggaacggga aataggtctc ctaggtgcct   4740
 gaagcgctga gcaacctggg taccctggtg gggatgcagg gaaggccggg gcagagaaag   4800
 cgaaggtcga cccagggctg taggaagcca taggagagtg accacgggat tccctgagaa   4860
 acagggccgg ccccccaact tcagggaccc accgcccatt ccccgagagc tgtcggaacc   4920
 agatgcaacc cggcagccca gagaactctc ctgggaggct gtgggtgagc caggccaaca   4980
 ttggtgtccc tgtccccaga gggaggagca ggcaggagag agaggggaag gaggtatgaa   5040
 tcccagtccc caggaaccta gctctttaaa ctctggggag tcggattcag gaaacacccc   5100
 caggaggcca agcctgaaaa cagaggggag ggaggaagga aggagtccca gcaggagcac   5160
 agccctggtt tcctgtcact cagagctgat tcacaggagg aggggaggtt ggggggcggg   5220
 agacaaaaac cacacctctt tttatataag gtttcatatt taatttggtc atggattcat   5280
 aaatacataa gtattttgta cacaaaaaaa aaaaaaaggg gcggccgttt taaaggaccc   5340
 ttgggggggc ccaagtttac ccgggcatgc agaggaatag ttctctcctt atagggagcc   5400
 gaattaaaac gcaactggga a                                             5421



      <210> 1343
      <211> 1871
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1871)
      <223> n = a,t,c or g


      <400> 1343
 atgtccagca aaggctccgt ggttctggcc tacagtggcg gcctggacac ctcgtgcatc     60
 ctcgtgtggc tgaaggaaca aggctatgac gtcattgcct atctggccaa cattggccag    120
 aaggaagact tcgaggaagc caggaagaag gcactgaagc ttggggccaa aaaggtgttc    180
 attgaggatg tcagcaggga gtttgtggag gagttcatct ggccggccat ccagtccagc    240
 gcactgtatg aggaccgcta cctcctgggc accttttttt gccaggccct gcatcgcccg    300
 caaacaagtg gaaattcgcc cagcgggagg gggccaagta tgtgtcccac ggcgccacag    360
 gaaaggggaa cgatcaggtc cggtttgagc tcagctgcta ctcactggcc cccccagata    420
 aaggtcattg ctccctggag gatgcctgaa ttctacaacc ggttcaaggg ccgcaatgac    480
 ctgatggagt acgcaaagct aacatgggat tcccatcccg gtcactccca agaacccgtg    540
 gagcatggat gagaacctca tgcacatcag ctacgaggct ggaatcctgg agaaccccaa    600
 gaaccaagcg cctccaggtc tctacacgaa gacccaggac ccagccaaag cccccaacac    660
 ccctgacatt ctcgagatcg agtttcaaaa aaggggtccc tgtggaaggt ggaccaacgt    720
 tcaaggatgg gcaccaccca ccagaccttt cttggagctc tttcatgtac ctgaacgaag    780
 tcgcgggcaa gcatggcgtt gggccgtatt tgacatcgtg ggagaaccgc tttcattggg    840
 aattgaagtc ccgaggtatc ttacggagac cccaggcagg gcaccatcct ttaccatgct    900
 catttagaca tcgaggcctt caccatgggc ggggataggg cgcaaatacc aaaccagggt    960
 ctgggctttg aatttgttga gcttggtgta taccggtttt ctggcacagc ccctgagtgt   1020
 gaattggtcg gcccttgcct tcgccaaagt ccccaggagc gagtggaagg gaaaagtgca   1080
 ggtgtcccgt ccctcaaagg gcccaggtgt acatccctcg gcccggaagt cccccactgt   1140
 tctctctaca atgaaggagc tggtgaagca tggaacgtgc cagggtgatt atgaagccca   1200
 actgattgcc acccgggttc atccaaacat caatttccct caaggctgaa gggaattatc   1260
 atcgtcttcc cagagcaaag gtcactgccc aaattagacc ccgtgtacaa tgaggagctt   1320
 ggggcctccc tcaatttgca agatcccccc aagtacaggc gcctaattgt tgtgataatt   1380
 tgtaattgtg acttgttctc cccggctggc agcgtaagtg gggctgccag gccccagctt   1440
 tgttccctgg tccccctgaa gcctgcaaac gttgtcatcg aagggaaggg tggggggcag   1500
 ctgcaggtgg ggagctataa aaatgacaat taaaagagac actagtcttt tatttctann   1560
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnttaa ttatgggttt cttaggccaa   1620
 cctttgtgtt ttcggaccta agtgctgccg aaggccgcca tttgccagac agcctgttaa   1680
 tccggctgtc gacccctctc cagcaaaaac taggaatcca gatgtgccgc ctgggtccga   1740
 tcctatccag catcctggga atctgtcacc aactgtggtc ctgtggcaaa tgtcaagaaa   1800
 ccaaataaaa ttcagggaat gccctttggg ggcatcaacg cacagccctt tctctggaca   1860
 tcacttttac t                                                        1871



      <210> 1344
      <211> 748
      <212> DNA
      <213> Homo sapiens


      <400> 1344
 cggtcccgcg ggtctgtctc ttgcttcaac agtgtttgga cggaacagat ccggggactg     60
 ggcttccagc ctccgaccgc cctccgattt cctctccgct tgcaacctcc gggaccatct    120
 tctcggccat ctcctgcttc tgggacctgc cagcaccgtt tttgtggtta gctccttctt    180
 gccaaccaac catgagctcc cagattcgtc agaattattc caccgacgtg gaggcagccg    240
 tcaacagcct ggtcaatttg tacctgcagg cctcctacac ctacctctct ctgggcttct    300
 atttcgaccg cgatgatgtg gctctggaag gcgtgagcca cttcttccgc gaactggccg    360
 aggagaagcc gcgagggcta cgagcgtctt cttgagaatg caaaaccaag cgtggcggcc    420
 gcgctctctt ccaggacatc aagaagccag ctgaagatga gtggggtaaa accccagacg    480
 ccatgaaagc tgccatggcc ctggagaaaa agctgaacca ggcccttttg gatcttcatg    540
 ccctgggttc tgcccgcacg gacccccatc tctgtgactt cctggagact cacttcctag    600
 atgaggaagt gaagcttatc aagaagatgg gtgaccacct gaccaacctc cacaggctgg    660
 gtggcccgga ggctgggctg ggcgagtatc tcttcgaaag gctcactctc aagcacgact    720
 aaaagccttc tgagcccagc gacttctg                                       748



      <210> 1345
      <211> 1827
      <212> DNA
      <213> Homo sapiens


      <400> 1345
 atggcaatac tgagggccag agcggccgaa atcctgtttc aggagacagc ggcttcccct     60
 caggctctgc cacgtctcca ggccagacag ggccgggcta aggtccgccg gcgctcccgc    120
 cagtctcccc taaagtcagc gccctggaag ctgagcctgg accacgggac tagggggctc    180
 gcaaacgaca tcggcgtcca gtggcgccgg ccggcccgcc caccttccag ggacaccgtc    240
 cctcggggtc tggctctggc gcctgcaagc catgccatgc catgccaccc ccctcataca    300
 cgcgcctcgg agccacctgg cgctcacctg gggaccggga aagtgcctgc gtggtcgctg    360
 aagagtgtgg tgagatgtga gcagagacgt gtaatgcagc aggcctgtgc ttatccggac    420
 agaaagaagg gcatgcaaag acttaaggat ggagtgtgct cggcatgtgc gcagacaaca    480
 gggaagcagg actgtgagaa tgcttggtgt gtccctttaa tacaagtgga aactgaacag    540
 ccagaagaaa gcttccctaa cactgaaacc aatggtgaat ttggtaaatg ccctgcagaa    600
 gatatggaag aggaacaagc attgaaaaga tctagaaaca ctgatgagat ggttgagtta    660
 cacattctgc ttcagaacaa gaattctggg gcagttattg gagaaggagg taagaatatt    720
 aaggctccct gtatagacta cagtgccagt gtttcagtcc cagacagcag tggccccaag    780
 tgcatactga gtatcagtgc tggtattgaa acaattggag aaattctaaa gaaaatcatc    840
 cctaccttgg aagagggcct ccagttgcca ttactcactc caaccagcca gctcctgctg    900
 gaatctgatg ctgtggaatg cttaaattac caacactata aaggaagaga ctttgagtgc    960
 gagttgaagc tgttgattta tcagagtcta gcaggaggaa tattggggtc aaaggaatgc   1020
 tgttctcatc ccactgacag agttgttctt attggaggaa aacccaatag ggttgtagag   1080
 tgcataaaga tcatccttga tcttatatct gagtctccca tcaaaggacc tgcacagcct   1140
 tatgatccca gtttttacaa tgaaacctat gattatggtg gttttacaat gatgtttgat   1200
 gaccgccctg gatgcccagt gggatttcca atgtggggaa gaggtggttt tgacagaatg   1260
 cctcctggtt ggggtgggcg tcccatgcct ccatctagaa gagatatgag ccctcatcga   1320
 ggaccacctc ctcctcttac tggacgaggt ggccggggtg gtagcagagc tcggaatctt   1380
 cctcttcctc caccaccacc acctagaggg gaagacctaa tggcctatga cagaagaggg   1440
 agacctggag actgttacga tggcatggtt ggtttcagtc ctgatgaaac ttggaactct   1500
 gcaatagata catggagccc atcggaatgg cagatggctt atgaaccaca gggtggctcc   1560
 ggatatgatt attcctatgc agggattggt ggctcatatg gtgatcttgg tggacctatt   1620
 actactgcac aagtaactat tcccaaagat ttgactggat ctattattgg caaaggtggt   1680
 cagcggatta aacaaatcgg tcatgagttg ggagcttcaa tcaaaattga tgagccttta   1740
 gaaggatccg aagatcagat cactatcatt acaggaacac aggaccagat acagaatgca   1800
 caatatttgc tgcagaacaa tgtgtag                                       1827



      <210> 1346
      <211> 975
      <212> DNA
      <213> Homo sapiens


      <400> 1346
 gtccagtgtg gtggaattcc gccgccactg tccggccaca gcctaacgct cttcgctgtc     60
 gtttgcggtc tcgcgcaggg cggccccggt tctggtgttt ggcgtcggaa ttaaacaacc    120
 accatgtcga gcaaaaaggc aaagaccaag accaccaaga agcgccctca gcgtgcaaca    180
 tccaatgtgt ttgccatgtt tgaccagtca cagattcagg agttcaaaga ggccttcaac    240
 atgattgatc agaacagaga tggcttcatc gacaaggaag atttgcatga tatgcttgct    300
 tctctaggga agaatcccac tgatgcatac cttgatgcca tgatgaatga ggccccaggg    360
 cccatcaatt tcaccatgtt cctgaccatg tttggtgaga agttaaatgg cacagatcct    420
 gaagatgtca tcagaaacgc ctttgctctt gctttgatga agaagcaaca ggcaccattc    480
 aggaagatta cctaagagag ctgctgacaa ccatggggga tcggtttaca gatgaggaag    540
 tggatgagct gtacagagaa gcacctattg acaaaaaggg gaatttcaat tacatcgagt    600
 tcacacgcat cctgaaacat ggagccaaag acaaagatga ctgaaagaac tttagctaaa    660
 atcttccagt tacattgtct tactctcttt tacttctcag acacttcccc caccctcata    720
 gaacctgttg catgcaactt agtttcacag ctttgcctct tctttttgat gtatttattc    780
 cagacctttc tgccacttta gcacttggta taatcagact gggaaatggg ggatgagggt    840
 ggtaaattgt attgaaaaag atcgcgaata aaaatcaaca aagtgtgaaa gcccagaaaa    900
 atatattcgt atttcctggg ttttgctggg atttttacat ttttatataa taaaaatgtt    960
 attttgaaaa aaaaa                                                     975



      <210> 1347
      <211> 533
      <212> DNA
      <213> Homo sapiens


      <400> 1347
 agagagagaa ctagtctcga gttttttttt tttttttctt ttttccggcg ttcaagatgt     60
 cgaagcgagg acgtggtggg tcctctggtg cgaaattccg gatttccttg ggtcttccgg    120
 taggagctgt aatcaattgt gctgacaaca caggagccaa aaacctgtat atcatctccg    180
 tgaaggggat caagggacgg ctgaacagac ttcccgctgc tggtgtgggt gacatggtga    240
 tggccacagt caagaaaggc aaaccagagc tcagaaaaaa ggtacatcca gcagtggtca    300
 ttcgacaacg aaagtcatac cgtagaaaag atggcgtgtt tctttatttt gaagataatg    360
 caggagtcat agtgaacaat aaaggcgaga tgaaaggttc tgccattaca ggaccagtag    420
 caaaggagtg tgcagacttg tggccccgga ttgcatccaa tgctggcagc attgcatgat    480
 tctccagtat atttgtaaaa aataaaaaaa aactaaaccc attaaaaaaa aaa           533



      <210> 1348
      <211> 551
      <212> DNA
      <213> Homo sapiens


      <400> 1348
 ccgggatcgc gctgatgtgg ccccaacccc gcctccctcc ccgccccgcg atgtcggaag     60
 aaacccgaca gagcaaattg gccgcagcga agaaaaagtt gagagaatat cagcagagga    120
 atagccctgg tgttcctaca ggagcgaaaa agaagaagaa aataaaaaat ggcagtaacc    180
 ctgagacaac cacttctggt ggttgccact cacctgagga tacacccaag gacaatgctg    240
 ctactctaca accatctgat gacaccgtgt tacctggcgg tgtcccttcc cctggtgcca    300
 gtctcactag catggcggca tctcagaatc atgatgctga caatgtccct aatctcatgg    360
 atgaaaccaa gactttctca tcaaccgaga gcctgcgaca actctcccaa cagctcaatg    420
 gtcttgtttg tgagtctgcg acatgtgtca atggggaggg ccctgcatcg tctgctaacc    480
 tgaaggatct ggagagccgg taccaacagc tagcggtaac cctggactcc agctatgtaa    540
 caaacaaaca a                                                         551



      <210> 1349
      <211> 3300
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(3300)
      <223> n = a,t,c or g


      <400> 1349
 atggcgggcg cccttccccc agcctcgctg ccgccttgca gtttgatctc agactgctgt     60
 gctagcaatc agggagactc cgtgggccta ggatcctccg agccaggtgc gggatataat    120
 ctcgtggtgc accgtttttt aagcaggtca gaaaagcgca gtattcgggt gggagtgacc    180
 cgattttcta gggatttccg atttggaccc cccatcaaca agattttcgc ctgtggggca    240
 aaccagcgtg gacggcttgc tgcaattctc tcagggccag ccggtgaagg gcaatcagct    300
 gttgcccgtc tcactggtaa aaagaaaaac caccctggcg cccaatacgc aacccgcctc    360
 tccccgcgcg ttggccgatt cattaatgca gctggcacga caggtttccc gactggaaag    420
 cgggcagtga gcgcaacgca attaatgtcc aatactcacc ggttgaaaat atttggtaat    480
 gacccccagc tgccccgagg gggattcgtt attggcgcgc gtaggagtaa tggctcccgg    540
 aaacgccatt actttgctgg taatgaacgt gcccaggagc tgcttactga ggacgcactg    600
 gatgatctca tcctttcttt tctactgact ggtcaacaga caccggcgtt cggtcgaaga    660
 gtatctggtg tcatagaaat tgccgatggg agtcgccgtc gtaaagctgc tgcacttacc    720
 gaaagtgatt atcgtgttct ggttggcgag ctggatgatg agcagatggc tgcattatcc    780
 agattgggta acgattatcg cccaacaagt gcttatgaac gtggtcagcg ttatgcaagc    840
 ccattgcaga atgaatttgc tggaaatatt tctgcgctgg ctgatgcgga aaatatttca    900
 cgtaagatta ttacccgctg tatcaacacc gccaaattgc ctaaatcagt tgttgctctt    960
 ttttctcacc ccggtgaact atctgcccgg tcagacacct ccaacaggag cattcagctg   1020
 gcatcaggtt ggtgcccccc tcggatggag ctgccagagg aaggagcagt cttcaatctt   1080
 tgctcttttg cagcctttac tagtgatacc ttcagggatt ttgccgattt cggacccccc   1140
 atcacacagg attttcgcct gctggggcaa accagcgtgg accgcttgct gcaactctct   1200
 cagggccagg cggtgaaggg caatcagctg ttgcccgtct cactggtgaa aagaaaaacc   1260
 accctggcgc ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag   1320
 ctggcacgac aggtttcccg actggaaagc gggcaggatt ttgccgattt cggaaccacc   1380
 atcaaacagg attttcgcct gctggggcaa accagcgtgg accgcttgct gcaactctct   1440
 cagggccagg cggtgaaggg caatcagctg ttgcccgtct cactggtgaa aagaaaaacc   1500
 accctggcgc ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag   1560
 ctggcacgac aggtttcccg actggaaagc gggcaaaata aagacccaac tcaatggatt   1620
 gctacttttg gtgcaactat aacaccaccc gcagtgaaac gaaatgtgag gaaaattatt   1680
 cttcatgaga attaccatag agaaacaaat gaaaatgaca ccgctttggt tcagctctct   1740
 actggagttg agttttcaaa tatagtccag agagtttgcc tcccagactc atctataaag   1800
 ttgccaccta aaacaagtgt gttcgtcaca ggatttggat ccattgtaga tgatgcctcg   1860
 ctgccgcctt gcagtttgat ctcagactgc tgtgctagca atcagggaga ctccgtgggc   1920
 ctaggatcct ccgagccagg tgcgggatat aatctcgtgg tgcaccgttt tttaagcagg   1980
 tcagaaaagc gcagtattcg ggtgggagga cccgattttc taggggattt ttgttcccaa   2040
 atgggaacca acactcaacc ctatcttggg gctattcttt ttattaataa gggatttgcc   2100
 cgatttggga acccaccatc caacagggat ttttcgcttg ctggggcaaa accagcgtgg   2160
 acccgcttgc tgcacttctc tcagggccca gggggtgaag ggcaatcagc tgttgcccgt   2220
 ctcactggtg aaaagaaaaa ccaccctggc gctcaatacg caaaccgcct ctccccgcgc   2280
 gttggccgat tcattaatgc agctggcacg acaggtttcc tgactggaaa gcgggcagtg   2340
 agcgcaacgc aattaataat aaccaataca gagaagtgct taaaggagct gatgaagctg   2400
 aaaaccaagg ctcgagaact acgtgaagaa tgcagaagcc tcaggagccg atgcgatcaa   2460
 ctggaagaaa gggtgtcagc aatggaagat gaaatgaatg aaatgaagcg agaagggaag   2520
 tttagagaaa aaagaataaa aagaaacgag caaagcctcc aagaaatatg ggactatgtg   2580
 aaaagaccaa atctacgtct gattggtgta actgaaagtg atggggagaa tggaaccaag   2640
 ttggaaaaca ctctgcagga tattatccag gagaacttcc ccaacctagc aaggcagtcc   2700
 aacgttcaga tgtctaggat atttcgacat tcttctgtag gcggtcgatt tatcaaatct   2760
 catgttatca aattaagatt gggtaacgat tatcgcccac caagggctta tgcacgtggt   2820
 cagcgttatg caacccgatt gcagaatgaa tttgctgnaa atatttctgc gctggctgat   2880
 gcggaaaata tttcacgtaa gattattacc cgctgtatca accccgccaa attgcctaaa   2940
 tcagttgttg ctctnttttc tcaccccggt gaactatctg cccggtcagg tgatgcactt   3000
 caaaaagcct ttacagataa agaggaatta cttaagcagc aggcatctaa ccttcatgag   3060
 cagaaaaaag ctggggtgat atttgaagct gaagaagtta tcactctttt aacttctgtg   3120
 cttaaaacgt catctgcatc aagaactagt ttaagctcac cacatcagtt tgctcctgga   3180
 gcgacagtat tgtataaggg cgataaaatg gtgcttaacc tggacaggtc tcgtgttcca   3240
 actgagtgta tagagaaaat tgaggccatt cttaaggaac ttgaaaagcc agcaccctga   3300



      <210> 1350
      <211> 1429
      <212> DNA
      <213> Homo sapiens


      <400> 1350
 accaaggacc cgtgtggaag gaggcggctc cccctagcct gccctgacct acaggctagg     60
 tggtggtctc cttgttttgg tgtcaaggac tcagtaaaag catctatttt tttagcactt    120
 aagctggcaa ggcggtaggg gcatgcactg ttaggtggtg gccaccccca gggtcagggg    180
 aaaagaatgg gtccatagag tgcccttgaa gcagagaaca gccccgagca gtgtgaggac    240
 agaggcatcc cagcctcagc cggtgggaac ggctgccact cccccagagc cctgccaccc    300
 catgtgttcc ttaggctggt ggccaaggcc atgtgtgagg gaagaggggt acctctcttc    360
 ccttgcttgc tggcctgggg gtattttcca aaacagcgct tttcgcacac atgcaggttg    420
 caccgagagg tctggagctg tggctgagcc acctctggtg gatgttgagc caggaggttg    480
 ggcaaaggcc ggatgctgat gccagcgctg gaggtggtga tactgggggc ggggaaggcc    540
 tagaaatact ttgagccatg gccttgccag tgtcccgtgc cctccagtgt caaagatttg    600
 gggcactgcc cgtcgaaatg gaaaggttgg tgctcagcct ctggagcctc acctgcaggg    660
 cgtccccagc taacacccat ccacgcacca cctccaggac gagaacccgt tgatgtcaaa    720
 accaagtgcc cagtggaggc ggtgaagctc tcggaaatgc tgccacctgt gtgaggccgg    780
 gtctgaactc gagggagtcg gagctcagct gtcggtttaa agagacactg aggggaccgg    840
 gctgccgccc tcagcctgca ttcctgtgcg caatcgattc cgcaatgaca gcaccttact    900
 ccttcctgcg gcaggctcac ccctgcctgt gggatgttgt gagaggaaca tgagccagac    960
 aaagacttgg ctcaagggct cccgtggaaa caaaccccag gaatgccacg ggggaagctg   1020
 ggggaagccc cccaccctgg ggcagcccca gcaggcccgc tgaaacaaac acccccagaa   1080
 gcccagcact gtggcagggt gcctggggag atgcccctct gagccttccc tcccccctca   1140
 gacctgaatg cacccccaca gttgggggct gcccctgccc actcccctgg taatgcataa   1200
 aaggggaggg gaaggttccc ctggggcttg agcctcccct ctgtggaggt gaggagggga   1260
 gattccgttc acatcccagg aggggcaaaa tgactgatgt atttttatgt atctacacag   1320
 agagtgcatt ttctctccaa agatgctgtc tggttaacaa aggaataact taagaaattg   1380
 attgattatc ttaataaact gtgcaaaccc aaaaaaaaaa aaaaaaaaa               1429



      <210> 1351
      <211> 3215
      <212> DNA
      <213> Homo sapiens


      <400> 1351
 ggaattcccg ggtcgacgat ttcgtgttgt atctgctgtt cgctggctgg gcctccgcag     60
 caggcttggc cagccgctga cgggtcggcg ggcgggtttg tgtgaacagg cacgcagctg    120
 cagattttat tctggtagtg caaccctctc aaaggttgaa ggaactgatg taacagggat    180
 tgaagaagta gtaattccaa aaaagaaaac ttgggataaa gtagccgttc ttcaggcact    240
 tgcatccaca gtaaacaggg ataccacagc tgtgccttat gtgtttcaag atgatcctta    300
 ccttatgcca gcatcatctt tggaatctcg ttcattttta ctggcaaaga aatccgggga    360
 gaatgtggcc aagtttatta ttaattcata ccccaaatat tttcagaagg acatagctga    420
 acctcatata ccgtgtttaa tgcctgagta ctttgaacct cagatcaaag acataagtga    480
 agccgccctg aaggaacgaa ttgagctcag aaaagtcaaa gcctctgtgg acatgtttga    540
 tcagcttttg caagcaggaa ccactgtgtc tcttgaaaca acaaatagtc tcttggattt    600
 attgtgttac tatggtgacc aggagccctc aactgattac cattttcaac aaactggaca    660
 gtcagaagca ttggaagagg aaaatgatga gacatctagg aggaaagctg gtcatcagtt    720
 tggagttaca tggcgagcaa aaaacaacgc tgagagaatc ttttctctaa tgccagagaa    780
 aaatgaacat tcctattgca caatgatccg aggaatggtg aagcaccgag cttatgagca    840
 ggcattaaac ttgtacactg agttactaaa caacagactc catgctgatg tatacacatt    900
 taatgcattg attgaagcaa cagtatgtgc gataaatgag aaatttgagg aaaaatggag    960
 taaaatactg gagctgctaa gacacatggt tgcacagaag gtgaaaccaa atcttcagac   1020
 ttttaatacc attctgaaat gtctccgaag atttcatgtg tttgcaagat cgccagcctt   1080
 acaggtttta cgtgaaatga aagccattgg aatagaaccc tcgcttgcaa catatcacca   1140
 tattattcgc ctgtttgatc aacctggaga ccctttaaag agatcatcct tcatcattta   1200
 tgatataatg aatgaattaa tgggaaagag attttctcca aaggacccgg atgatgataa   1260
 gttttttcag tcagccatga gcatatgctc atctctcaga gatctagaac ttgcctacca   1320
 agtacatggc cttttaaaaa ccggagacaa ctggaaattc attggacctg atcaacatcg   1380
 taatttctat tattccaagt tcttcgattt gatttgtcta atggaacaaa ttgatgttac   1440
 cttgaagtgg tatgaggacc tgataccttc agcctacttt ccccactccc aaacaatgat   1500
 acatcttctc caagcattgg atgtggccaa tcggctagaa gtgattccta aaatttggaa   1560
 agatagtaaa gaatatggtc atactttccg cagtgacctg agagaagaga tcctgatgct   1620
 catggcaagg gacaagcacc caccagagct tcaggtggca tttgctgact gtgctgctga   1680
 tatcaaatct gcgtatgaaa gccaacccat cagacagact gctcaggatt ggccagccac   1740
 ctctctcaac tgtatagcta tcctcttttt aagggctggg agaactcagg aagcctggaa   1800
 aatgttgggg cttttcagga agcataataa gattcctaga agtgagttgc tgaatgagct   1860
 tatggacagt gcaaaagtgt ctaacagccc ttcccaggcc attgaagtag tagagctggc   1920
 aagtgccttc agcttaccta tttgtgaggg cctcacccag agagtaatga gtgattttgc   1980
 aatcaaccag gaacaaaagg aagccctaag taatctaact gcattgacca gtgacagtga   2040
 tactgacagc agcagtgaca gcgacagtga caccagtgaa ggcaaatgaa agtggagatt   2100
 caggagcagc aatggtctca ccatagctgc tggaatcaca cctgagaact gagatatacc   2160
 aatatttaac attgttacaa agaagaaaag atacagattt ggtgaatttg ttactgtgag   2220
 gtacagtcag tacacagctg acttatgtag atttaagctg ctaatatgct acttaaccat   2280
 ctattaatgc accattaaag gcttagcatt taagtagcaa cattgcggtt ttcagacaca   2340
 tggtgaggtc catggctctt gtcatcagga taagcctgca cacctagagt gtcggtgagc   2400
 tgacctcacg atgctgtcct cgtgcgattg ccctctcctg ctgctggact tctgcctttg   2460
 ttggcctgat gtgctgctgt gatgctggtc cttcatctta ggtgttcatg cagttctaac   2520
 acagttgggg ttgggtcaat agtttcccaa tttcaggata tttcgatgtc agaaataacg   2580
 catcttagga atgactaaac aagataatgg cagtttaggc tgcacaactg gtaaaatgac   2640
 tgtagataaa tgttgtaatt agtgtacacg tttgtatttt tgttaatata gccgctgcca   2700
 tagttttcta acttgaacag ccatgaatgt ttcatgtctc cctttttttt tgtctatagc   2760
 tgttacctat tttagtggtt gaaatgagag ctagtgatga cagaaggatg tggaatgtct   2820
 tcttgacatc attgtgtatt gctggtaatc aagttggtaa cgactacttc tagcagctct   2880
 taccactatg acttaagtgg tcctggaagg cagtaagtgg aggtttgcag cattcctgcc   2940
 ttcatgaggg cttctaccac tgaccacttt gcacgtacct ggctcccaga tttacttagg   3000
 taccccacga gtcgtccaca taagcagctt catctttacc ttgccagagt tgacaattat   3060
 gggatactct agtctactta tacttgtgtt cccatctgtc tgccatcctc tgaaggccag   3120
 gacccagtca tacatcctta gaaaccaaag tatggttttt gttttctctt ggaatgtcag   3180
 gtcttaaggc atttaattga gggacaaaaa aaaaa                              3215



      <210> 1352
      <211> 374
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(374)
      <223> n = a,t,c or g


      <400> 1352
 tgttcaagat ccagaacctc attgccagca ccgtccgcac ggtgatggtg gccgactgca     60
 gccgcttcga cagccctgac ctgctgctgg aagccggtga cccggccacg tccccctgcc    120
 gcatctttga cctgggcagc gacaacgagg aggtggtggc tgtncccgac ccctcccacc    180
 ccaaggaggg cttgagctat tccctgagct gcgtgctgct tgggcggtcg cttcccagat    240
 gcctcatctc atgctatata ccattgtgtt tgtctgttgc ctcagggcct cacaaattct    300
 actaaccgca ctgcctatgc ccgataccac ctccttctct tacccttggc agtccacctc    360
 acttcccctc cacg                                                      374



      <210> 1353
      <211> 424
      <212> DNA
      <213> Homo sapiens


      <400> 1353
 ctctacccct tggagactgc ttttctccag ctctgtcaac tcaacctttc ccaccatgag     60
 tcggcaactg aacatcaagt ccagtggtga caagggcaac ttcagtgtgc attcggcagt    120
 ggtgccaagg aaggctgtgg gtagcctggc ttcttactgt gcagctggca gaggggctgg    180
 cgctggcttt ggcagtcgga gcctctatag ccttggaggg aatcggcgta tttctttcaa    240
 tgtggctggt ggcggcgttc gggctggagg ttacggcttc aggcctggct ctgggtatgg    300
 agggggccgg gccagtggct ttgctggcag tatgtttggc agtgtggccc tggggcctgc    360
 atgtttgtct gtgtgcccac ctgggggcat ccaccaggtc actgtcaaca agagcctctt    420
 ggcg                                                                 424



      <210> 1354
      <211> 423
      <212> DNA
      <213> Homo sapiens


      <400> 1354
 tgctcaatac ggaacatatt ctcagtcctc ctctggtcta caaagcctgt gatttcttgt     60
 ctatggacag aacgtctggt ttaatctaca ggaacccata acttcctgaa gctttatgct    120
 taacagtgac aacgtgagtc agttgaattt tattgtgttt cagtccgtag agtattagct    180
 acagaaacct ttccattgcc atactgagaa actgcagcag gcagtgtgcc tacaggtcta    240
 caaagaaact tcagatcatc ttcttgaggg aaagaagctg aagtgctaca taagatgctt    300
 gtgcttcata actctcagaa gctgcagatt ctgtataaat ccttagaaaa gagcatccct    360
 gaatccataa aggtatatgg cgccattttc aacataaaag ataaaaaccc tttcaacatg    420
 gag                                                                  423



      <210> 1355
      <211> 441
      <212> DNA
      <213> Homo sapiens


      <400> 1355
 agatccaact cgtaacacaa cctcacaaaa agcggtccaa atttatactc ccccaaagtg     60
 aaatttttgt tctctgcatg gtacctgtaa atgacatttt tagccagttc cacatggtcc    120
 cgagactcac acaaatgtag taaggttatc aactccccct tcaagatgag cttgttctgg    180
 gtcagtttct ttttcaagtt tctaaaatac gtttctttag tgccagaaag attacatgca    240
 acagccactt tcttttgttg aaattctttt aatttcccca cattatctgt aagtaggtat    300
 cttttagctc cgagagggca gcggcagctg acagagccgg agcctcccac cccaggatac    360
 accacaatct gcagcgcctg caggagaact cgattcgagg gccgaaatac agcagccata    420
 ctgtctcggc ggacgcgtgg g                                              441



      <210> 1356
      <211> 1155
      <212> DNA
      <213> Homo sapiens


      <400> 1356
 cgcgtggcgg gcaggcggca ggaggcgggt gggtcaaggt aactctgggc tacagagtcc     60
 ttgctggggg ttcggggagc gcttggaccc cggcttctgg gacgcgtcag gagaagggag    120
 cactggcttt gctttcatca ggccaaagat gcctttcttt gggaatacgt tcagtccgaa    180
 gaagacacct cctcggaagt cggcatctct ctccaacctg cattctttgg atcgatcaac    240
 ccgggaggtg gagctgggct tggaatacgg atccccgact atgaacctgg cagggcaaag    300
 cctgaagttt gaaaatggcc agtggatagc agagacaggg gttagtggcg gtgtggaccg    360
 gagggaggtt cagcgccttc gcaggcggaa ccagcagttg gaggaagaga acaatctctt    420
 gcggctgaaa gtggacatct tattagacat gctttcagag tccactgctg aatcccactt    480
 aatggagaag gaactggatg aactgaggat cagccggaag agaaaatgaa gaccccagag    540
 acatttattg gggagtagga tgtggctgag tgcttttttt ttggccagac tagcggattc    600
 agtcctggaa gagagtatca tataatgaga cccacaggca ctggcaccct tgggttggca    660
 atagaaggtg acatggaatg gagaaaacca agattccaga tggggatagt aactagaagg    720
 tgcttcagat gcactgcctg cgggtgccag tctgaaaacc agaccgcaca gaggcctggg    780
 gctgctgatg agcttttcgg tgctctccac acacaagctc gcaaacacac atgtcccaga    840
 atagctctgt tgggttgtgt tgggagaagc ggctggagtt cattctctca cccccttatg    900
 ttggtgtttg gcgtgtgaca gcagttctac agagctctgt gttggggtca tggatgagcg    960
 gctctcttgg ctcttaaagg caggcctctc tcttcttgcc tttaaagaat cctccttcct   1020
 cacacctggc ctcctctggc ttcagcttct cagcagcaag caccagcctt ccacaacaac   1080
 actatatttt tatgctactt tcctgtttgc actactactt ttttattaaa cgatgttaaa   1140
 taatcaaaaa aaaaa                                                    1155



      <210> 1357
      <211> 2375
      <212> DNA
      <213> Homo sapiens


      <400> 1357
 ccctctcatt tgtccacagt cggactatgg ggaagaggag ctgttcatct tccagcgaaa     60
 ccaaacctcc ctgattccag acctgtcgga ggagctggct gaagatcctg ccgatggcga    120
 caagtccagg gcctgggtcg ctgcagctga agagtccctt cccgagccag ttctggtgcc    180
 tgcagaattg gccacagaac ctgggtgcag acagaacaca aggacaaagg atgcatcctc    240
 tcaggaagga agagaccctg gcaggccttt tgaaagctct ggtgaagtca gcgctcttct    300
 tgggatggcc gaggagcccc ccaggtggct ggaaggcgac cttggaagcc tgtctttcaa    360
 caccaaagga tcccagggtc ctccctggga cccacaggcc gaagccactc tctcctgcca    420
 tgaaggagac ccaaaggcag agcccctcag cactgcctca caagaatctg tgaaccgccg    480
 ggccctccga caggagagaa ggaagatgat agagacggac atcctccaga aagtcacccg    540
 ggatgcctgc gcccgaccag cagtgacaaa gggagtcaag gtggacgcga gagaccacag    600
 tggagccaca gcccggatgc tggccaagca gtacggacac atgaagatcg tggccttgat    660
 ggacacttac tcgccctctc tgcccaagag cctctatcgg agcccagaaa agtacgaaga    720
 tctgagctct tctgacgagt cctgccctgc tcctcagaga cagaggcctt gccggaagaa    780
 gggtgtcagc atccacgagg gaccgcgagc cctggccagg atcacaggca ttggcctggg    840
 cggcagagcc ccacggcctc gctatgagca ggctcctccc cgtggctatg tcaccttcaa    900
 cagcagtggc gagaaccccc tggaagaaga gggcctctgc tgccgggatg tcacctcccc    960
 catcaatgag cgggacgtgg agagcagcag cagcagcagc agtcgggagg aacatgcttt   1020
 ctgtgccaac ctggggcccg tccagagcag cagcagcagc gagggcctgg ccagagccca   1080
 ggggctcagc agcgaagctt ctgtggagag caacgaggac tcggatcatg cctgtaaaag   1140
 ctcagctcgc aaacaagcta aaagttacat gaagaccaag aatcctgaca gccagtggcc   1200
 tccccgcgct gcaactgaca gggaaggctt tctcgctgag tccagccccc agactcagag   1260
 ggccccctac tcaggacccc aggaccttgc cgcactgctg gagcagatcg ggtgtctgaa   1320
 gtacctgcag gtgtttgagg agcaggacgt ggacctccgc atctttctga ccctcactga   1380
 gagcgacctg aaggaaattg gcatcacgct gtttgggccc aagaggaaga tgacgtccgc   1440
 cattgcccgc tggcacagca gtgcccgccc acccggggat gccctggagc tggcctacgc   1500
 cgaccggctg gaggctgaga tgcaggagct cgccatccag ctgcacaagc gctgcgagga   1560
 ggtagaggcc acgcggggcc aggtgtgtca ggagcaggag ctgcgcgccg tggtggagag   1620
 ctgcctgctg gagcaggacc gcgcccgcga ggacctccag gcccggctgc gggagacgtg   1680
 ggccctggcc cgggatgctg ccctcgtcct ggaccagctg cgagcctgtc aagctgagct   1740
 gtcatctcga gtgaggcagg accagccccc tggtgcagcc actctgggcc tagccgtccc   1800
 cccagctgac tccaagggct ggcaagcgtc cctgcaggcc atgagcctcc ccgagctctc   1860
 gggagccctg gaggaccgtg tccgtgagat ggggcaagca ctgtgcttag tgacccagag   1920
 cctggagaag ctgcaggtgc tgaacgggaa gaagtggcgg gagacctagc ctgcgggccg   1980
 aatctgacgt tgggtgattg gtccaccctg aagctgtgtg ccagggagtg aggaggacag   2040
 tgagcaggta gctgccatgt gcagcccagg cccagtgggg gccagaggat caggccccgg   2100
 gagcagccgg cagacagagg caagacgggg gctgcggccc tggctcggca gctcgggcca   2160
 gcactgaggc gggacgaggg cctcacccag aacctcatgg tgaggcccag agttcatggg   2220
 ctgccctggc ccataccagg cagggccctg gggggaaagt gtatccatat acacgcacag   2280
 gtgccaactg aggtgggacc ttaggaatga ggactggggc acctggaaaa tgccattttt   2340
 tggaaaataa aatttaagaa cagctaaaaa aaaaa                              2375



      <210> 1358
      <211> 467
      <212> DNA
      <213> Homo sapiens


      <400> 1358
 ctagtccagt gtggtggaaa acggcatctc cagcccgggc atctccggct ctggcatcac     60
 tttccaggtc ctcatccggc aggtcatcat ccgccaggtc agcctcggtg acaacctccc    120
 caaccagagt gtaccttgtt agagcaacac cagtgggggc tgtacccatc cgatcatctc    180
 ctgccaggtc agcaccagca accagggcca ccagggagag cccagtccag ttctggcagg    240
 gccacacagg gatcaggtac aaggagcaga gggagagctg tcccaagcac gctgttcgct    300
 gtgacggggt ggtggactgc aagctgaaga gtgacgagct gggctgcgtg aggattgact    360
 gggacaagtc tctgcttaaa atctactctg ggtcctccca tcagtggctt cccatctgta    420
 gcagcaactg gaatgactcc tactcagaga agacctgcca gcagctg                  467



      <210> 1359
      <211> 1293
      <212> DNA
      <213> Homo sapiens


      <400> 1359
 tttgaagcca aattggagag agatgtattt ataccagtgg ggctaaggag gaagcagtcc     60
 agtgggggac tttgagtgct gtgcagtgtt ctcttaagag tcgtagtaca gtcctggggt    120
 caagtctctt tccctaatct ttgctgggga agccttgagc cttgatttat ccttcccttg    180
 gctttgggct ttgaggaagt tggggatgga ggggatgatg cttctttagg tttctctatt    240
 ccaagcccct ctgaatttct agttgcaacc tcaggactca tccccctcca ggccttcctg    300
 gatgcagata tacacaaaga tggaagctgg gcggaggctg atgccatctt tggacagcag    360
 gtgaatgtgg cggtaacctt gttgcatgca ggtcccaggg caaggggtct tgcccaataa    420
 gtcatttcgg gatttccagt cataatccat tttcccaaaa cgcagcattg gaaagtcagg    480
 gcccagcacc cggaaacata gtgtctgccc ccagtatgga ttaaaaccat tgttctccac    540
 atagttggtc tcctgccgtg ctgtgtctag acgaacgcca aagatctgca ctttcaccag    600
 tggatccaca atggacccct ctttggtctt gtccactttg gggagttgct gaacgctgat    660
 cacctggttt aagagagtct gggctttgaa agggctgatg ggcttctcag ggtggaaaga    720
 actctggata tcacgcagga agtctggctt cagcacatag ccacagccgc cattctggcg    780
 gaaatgccca tcacagatgt ccatttcaag ccctgcagtc tgcatattca tggccactga    840
 gggccccagg agaaaagaag agcaagattc accatggagg ccttccagcc cctctttcag    900
 ggagttaaga agataggtac tgggtgcacg gtacctgctg gtaatatcca ctgatagcat    960
 ttctcagcct agcaattttc ttgagcattc cccaacccta ccatcactag agaacttatt   1020
 tcccacctgc tgctcctcca ctccctcttc ccagtccctg ctgcctcctc acccatctgg   1080
 cagcctgcat tccagagttc ctgggggttg tagttggaag agtctgtcct caggtcgctg   1140
 ggatacacac ggcttaactg ccaagtattg tgctgcacaa actcattgcc tgtaaaaggg   1200
 tatagagggg gagatggagg tggggtggaa tctcccactt ccctagtccc aaggaccatg   1260
 cctactcttc acccttctct ccagcatttg aag                                1293




      <210> 1360
      <211> 1332
      <212> DNA
      <213> Homo sapiens


      <400> 1360
 agtctgcagc ctgaaacagg agtttgtggg tcagagtttg tgggtcagag tttgtggggc     60
 tgggatagaa actcggggga ttggcgttca gatgctgacc acttccctct tctctgagca    120
 gggtgacttc accgaagacc agaccgcagg taggttatct ctgatcccta ccgaggtcac    180
 ccttagggag agggacaccc tccccccagc acctatcctc taatcttaat ctgtcatctc    240
 tttagcaccc ccatgagatt accccctgga ttattttctc ttcttctgga tcctccattt    300
 tcttttctca ctttcttcct ccctcccctt ccactctaga tctgatccca agcactgggt    360
 gagttttagg tggtgtggag ttcaaggagg ccttccagct gtttgaccga acaggtgatg    420
 gcaagatcct gtacagccag tgtggggatg tgatgagggc cctgggccag aaccctacca    480
 acgccgaggt gctcaaggtc ctggggaacc ccaagagtga tgagatgaat gtgaaggtgc    540
 tggactttga gcactttctg cccatgctgc agacagtggc caagaacaag gaccagggca    600
 cctatgagga ttatgtcgaa ggacttcggg tgtttgacaa ggaaggaaat ggcaccgtca    660
 tgggtgctga aatccggcat gttcttgtca cactgggtga gaagatgaca gaggaagaag    720
 tagagatgct ggtggcaggg catgaggaca gcaatggttg tatcaactat gaagcgtttg    780
 tgaggcatat cctgtcgggg tgacgggccc atggggcgga gctcgtccgc atggtgctga    840
 atggctgagg accttcccag tctccccaga gtccgtgcct ttccctgtgt gaattttgta    900
 tctagcctaa agtttcccta ggctttcttg tctcagcaac tttcccatct tgtctctctt    960
 ggatgatgtt tgccgtcagc attcaccaaa taaacttgct ctctgggccc tcaaaaaaaa   1020
 aacccaaaat cctggccact atgccaaaaa aagacctaaa atacccctac cccaagccca   1080
 tgcaagactg ggaacatgcc ggcttctctc cagcctatgt gcctttggtc caagaggtct   1140
 caccctcctg tccctggctg ggctaggtgg tcctgtccag gctcctgcag cgcccccctc   1200
 actttgacac tggactacga tgcagcctcc cttctgtgtc cccttgaggg taccctgggt   1260
 cccctcatca ggggcagagg catgaaagag tcggggctgg atggccaggg gcttctgggc   1320
 ccgatgccta ga                                                       1332



      <210> 1361
      <211> 819
      <212> DNA
      <213> Homo sapiens


      <400> 1361
 ccgccccgga atttccgggt cgacgatttc gtccgggagg gcggctcgca ggcaccatga     60
 ctcctgtgag gatgcagcac tccctggcag gtcagaccta tgccgtgccc ctcatccagc    120
 cagacctgcg gcgagaggag gccgtccagc agatggcgga tgccctgcag tacctgcaga    180
 aggtctctgg agacatcttc agcagcaggt agagcagagc cggagccagg tgcaggccat    240
 tggagagaag gtctccttgg cccaggccaa gattgagaag atcaagggca gcaagaaggc    300
 catcaaggtg ttctccagtg ccaagtaccc tgctccagag cgcctgcagg aatatggctc    360
 catcttcacg ggcgcccagg accctggcct gcagagacgc tcccgccaca ggatccagag    420
 caagcaccgc cccctggacg agcgggccct gcaggagaag ctgaagtact ttcctgtgtg    480
 cgtgagcacc aagccggagc ccgaggacga tgcagaagag ggacttgggg gtcttcccag    540
 caacatcagc tctgtcagct ccttgctgct cttcaacacc accgagaacc tgtacaagaa    600
 gtatgtcttc ctggaccccc tggctggtgc tgtaacaaag acccatgtga tgctgggggc    660
 agagacagag gagaagctgt ttgatgcccc cttgtcattc acagagagag cagctgacag    720
 caggtccaga gaatattcta tgtgcaaacc ttggcagtgc tgaaatgatg ttcacctact    780
 gctgacttcc acattgcaag actatgtcat gcggctggg                           819



      <210> 1362
      <211> 1445
      <212> DNA
      <213> Homo sapiens


      <400> 1362
 tttttttttt cagaatgaaa acacttacaa atcattttta ttatgaataa tttaggatat     60
 ttgggacatt catttctgag taaaatagtt caaaatagga ttttgttgat acctgttgat    120
 acatatttag aaacaaaaat gagatatcct tttgaaagtt tgcctttgta gtaaattcag    180
 tcattcaaat tgttttctct caagacccaa aaatgccagg ggcattgccg gctcttgagt    240
 ttattctttg tttcttcatc aaattcttcc atgggactct attaggtttc ccgggggtcc    300
 cagctcacct aggggggaaa ggggggtaat cgggttcccc aaaatgactt tatcctttcc    360
 tatggacatc tggttaacag cttgagggga cagaggatca tgaaccaaag catctgtgta    420
 aaaggaacca aggtatttct tcgggttcat ggggttgtcc tgggcacaca gatctgggcg    480
 catgctgaat ccatgggaga ttcttcccac tgtgaagggg aaggcaccac caccatgtgc    540
 gaaacacact ttcagtttgg gaaacttctc aaatactcca cccatgatca tggagcaaat    600
 ggctatggtg gtctctgctg gcattcctac aagccaaggg agccagtatt tggccattcg    660
 tccatccatc tgcatgtccc agggatgcac gaacagggaa cacttcagcc tttcggctgc    720
 cgcatagaca ggaaagagct cctgcgcgtt caggtcccac tcgttgacgt gggtgccaat    780
 ttggaccccg ggaaagccca gctctttcac acagcgctcc atctccttga ccgccagctc    840
 aggggcctgc atgggcaacg tccccagacc cacgaacctc ctggggtagc tcacaacggt    900
 gctggcaagg tcgttgttta aaagctggca caggtttaaa gtgtcctcag gtttggccca    960
 gtagctaaac atgacaggaa ctgtggaaag ggcttgcact gttactcctt tttggtccat   1020
 ttctctaata cgaacttctg gatcccagca attctctcgc accactctga agactttccc   1080
 atctttcaac aactttgctt ctcccttgct gtggtgttgg agctgcaccc agcctccgta   1140
 gccaaacctc tttcactggc tgccctgttt tccctgtctc acttcctcac tctactggtg   1200
 tttcctggga tcacctccaa agcaaactac ttgcatctga atccttgtct cagggtctgc   1260
 ttttttagat ctggccattc ttttggtaga atatgactat ggatgtcaat tttcatctcc   1320
 acaggatcag agaagcatgc aaggaaagaa gttttgatat caagagacct ttgtgaaaac   1380
 tgtggagtta attgatttac ttagtccctt tacagcaacc ttcaggcagc agtcagtagg   1440
 cctgc                                                               1445



      <210> 1363
      <211> 1929
      <212> DNA
      <213> Homo sapiens


      <400> 1363
 tttttttttt ttacagatca caggaatttt aaattgcaga tcagtcatgc tacttggggt     60
 gatcagaaag acttgaacac ttaccaagtg aataatttta ttaaggtcct gaaggtgagt    120
 gtccggaggt gctgggtaaa acacatcaca ggtaagaaat gggaaaccta cctcagcatt    180
 tctgaaaggc acaatctatg gaagggaaac ctagcgtaat aaaaccctca ctggatgtac    240
 atggaaagga gtatggtgag ctatttcctt tttaaaggat gagaccttca taaattggcc    300
 cctcggattc tggtgattcc cgccgcaagc gcaaatgctc cagtgtgtta tgaaaatgtt    360
 tgttaatctg ctctgtttct tcactggatt caagattcgg gaggtcttct cgaatctttt    420
 ggataagctg gtttaaaacc tgaattgtta ccgcatcatt ttccttttca taaaaataga    480
 tatatctgtt cagaatttct ataaaaagct gcacttgtag agaggggtcc atgcactgat    540
 ttgctatttt tagagctttt tttaggcact ccattaccct cttgcctccg tgaagctcct    600
 ccccattttt gtccgtgttt ctgccagacc agaagagatg tgcacaggtg ctcacagctc    660
 ggccctgatc aggtttcttt agaagtttgg atgcagcaag ggcacactga gtcctcagag    720
 gttcatgatt ctcttcactg aagcacttca tcctttcaaa agtgccaatg atcaaggtga    780
 tggcagctag ctgtgctttg gaatcgctga tttcatcttc atacagagaa aatgcctggg    840
 acatgaattc atatgcgact gtctcatgat tttcaaaacc aatttcccca gcagctagtg    900
 ctccttgaag aaaaagtctt aagggcaatt ctgccagctc tgctttgatc aaagcactga    960
 tagtctggtg ggcaaatgaa aaaatcttct ggcatttctt ttcccatttg tcatccactt   1020
 tagaattctc tttatatcga aaagccagct ggtaagctgc aaataccaaa ggtggcagtg   1080
 tgaagcgaat ccgctgattt ccaccagctc caaaatgttt tcgtgctgtg ttcaaaatca   1140
 agtactgctg gtcagggtcc tcagagcgca gcagatgaat gaagcggccc acaaggctct   1200
 gctcatcagc aaaatcttct ggatcagggt cttctacagg ttgatctggc tgatcttgaa   1260
 tcaacgtgga taccaaattc attatggaat ccacctggtc ttgagagaca atttctgtgt   1320
 tataatccag aacattacta agcacataac aactcatgct ctttctggac tcgtagtcaa   1380
 agtactcaaa gagtgggtga aaatgtttta atttcaagac tgttaaaata ttgttgtaag   1440
 tgtcaactgg tattttcaaa agtctggtga gttcctttga aactgcacta ctggtagcaa   1500
 tatgttcaag gttgagctta ttgaatatct ccactgttgt ttctagaact ttatcaacat   1560
 agtccacacg atcagggtaa catttcatgg caagattaat cagagagact tgtaaagata   1620
 caacatcctc tgaaggcatg tcttgtctag actgtatcac tgtagccacc tgctgtgaaa   1680
 atatatcaaa aagtttaata tccgctggga ttccaggtcc atcttcacgg tgagcaaata   1740
 aagctaatct atcaattaaa gcaatgatta tgttcttcac atttacattc tggtgtaact   1800
 cagcacaggc ccgaagaaaa ggattcaaag tctggaggtg aaattcatca gggaaaacct   1860
 gaataataca ctccatgaga tattcttgag ccaaagcatc cctacagttt acaacttgct   1920
 ccaatatgc                                                           1929



      <210> 1364
      <211> 399
      <212> DNA
      <213> Homo sapiens


      <400> 1364
 ggaaactttt tcagtattgc tcttctcttc tctctcacat tttccatgat tgacatctgg     60
 taaccacaga ggtatcccga gtgaaggtgg ccctggcctg cagcagctct gctctttttt    120
 ttcccctact ttcctaaact ttattaaaga aaaaagcact agaacatagt cacttttctg    180
 ggattcctcc ccgcaaaatg tgacgtttga ttttcaaaca tgccagaagt ggacatggtt    240
 cccagttgta ctaaataggt gagaagctga agtcctaaag tgttcatctt ccaacttttc    300
 ccagtctgtg gtctgtcctt ggatcagtaa taattgtctg aacagctact atggcttcat    360
 taatttttgg ctggagctct ctgagctctt ctatatgcg                           399



      <210> 1365
      <211> 991
      <212> DNA
      <213> Homo sapiens


      <400> 1365
 tctcaggtct ggaggtccaa tctttacatg tgaggttaaa agtataactg ttgtgggtta     60
 tataaactat tcaagttagg tctcttatgg tggcaaaatg gaagacttga gataggtgtt    120
 ggatgaccta aacctggagc cctatttttg taagattctt tcttttgttc tgaacttcag    180
 cttgcccagt tattggcgga attgaactcg atgccagatt tcttcccagt acgaacccca    240
 acctcagctt ctaggaagaa gacagtgagg cgggccttct cggagggaca gatcacgcgg    300
 cgtatgaacc caacccggag tgcgcggcct cctgagaagt ttgctctaga gaacttcact    360
 gtctcagccg ctaaatttgc ggaagagttt tacagcttcc gaagaaggaa gacaattggg    420
 gggaaatgcc gggagtacag acgacgtcac cgtatatctt cttttcggcc agtggaggat    480
 atcaccgaag aggacttaga aaatgttgcc ataactgttc gagataaaat ctatgataaa    540
 gttctgggta acacgtgcca tcagtgtcga caaaagacca tcgacaccaa gacagtgtgt    600
 cggaaccagg gttgctgtgg tgtgcgagga cagttctgtg gaccatgcct gcggaaccgc    660
 tatggggagg atgtcagatc ggcattgctg gacccggatt gggtgtgtcc cccctgtcgt    720
 gggatctgca attgcagcta ctgtcggaag cgtgacggcc gctgtgccac aggaatcctc    780
 attcatctgg ccaagtttta tggttatgac aatgttaagg aatatctgga gaggtaagta    840
 agtctctagc agcttacaaa acagcttgaa atcttgaggc tgagcacagg agaccctctg    900
 ggcaagtagt tgttgccttc ccgtgtgact tacttactta tataaaccac gagtaccatc    960
 cattctgtat ctgtttgcat tggaaaagct c                                   991



      <210> 1366
      <211> 876
      <212> DNA
      <213> Homo sapiens


      <400> 1366
 atgaagaaag aagatgcatt tttgaaggca ttctatattg ttcatgggaa gtggaactgt     60
 gtaaaaggct cattaaccag gactccatgc tgctgcacaa attgcctggc aggagggata    120
 tggtgcatga gagtccaaat cttccagctg gagaacaagg tgctgcctgg ctttccatgg    180
 gcttgcagag tggacctcta tggccagatt ggatttgatg ctgcagctca gtgcctttct    240
 ctgagtgtaa gtaaggcaga gccactggta aagaaggctc caccggagtt gagggagcag    300
 ctggccagaa aaactctcag tagtgataac cttaaatacc tgtttgacaa caaagatatc    360
 atgaaggtaa aacaaagcaa gaagaaaaaa gagcacagtt tcagaaagaa taatggatgc    420
 attaaaatca tcgcgttcag cgaccatgcc gaggacttcc gcaagctggg ctgcgaagtg    480
 ctgggcatct cagtggactc tcagttcacc cacctggctt ggatcaacaa cccccagagg    540
 gagggagact tgggccccct gaacatcccc ctgcttgctg aggtggccag tggcttgtct    600
 gaggattacg ccgtgctgaa aacagatgcg ggcattgcct acaggggccg ctttatcagt    660
 gatggcaagg gtgtcctttc cagatcactg ttaatgattt gcctgtggga cgctccgtgg    720
 atgaggctct gcggctggtc caggccttcc agtacgcaga agagcacgcg gaagtttgtc    780
 ccgctggctg gaagcctggc actgacacga ttaagctcaa cgtgggtgac agcaaggaaa    840
 atttatccaa acacaattag gctggctgac ggatag                              876



      <210> 1367
      <211> 1293
      <212> DNA
      <213> Homo sapiens


      <400> 1367
 ctttgtcaag agacttggag agagggatgg gcgaggtgtt gggggacaca ggggtgctct     60
 agaccctgtg agcactgact ctgcccctct ctcctcttag ctggctccag tgcccagacc    120
 caagcccccc actgctcaat ggacaccccc agcccagacc cgttgccttc gcctttgccc    180
 ggggaggaag agaaacctct ggccttatct cctcctgttc cccggggccg ccgaggccgt    240
 cgtcctgggg gagccacctc ctcaaatcgg acactcaagg cctccctccc tcgcaagcgg    300
 ggccgccccc ccaagtcagg gcaggagccc ccactggtgc aggtgcaggg ggtgacagcc    360
 ccagtaggca gcagtggcgg gagcgacctc ctcctgatcg atgatcaggg tgtgccctat    420
 acggtctctg aaggttcagc ggctgggcct gagggctctg gccccaggaa ggccccacac    480
 ttctgcccgg tgtgcctgcg ggccttcccc tacctctccg acctggagcg ccacagcatc    540
 tcgcactcag agctgaagcc gcaccagtgc aaggtttgcg gcaagacctt caagcgctcc    600
 agccacctgc ggcggcactg caacatccat gccggcctgc ggcccttccg ctgcccgctg    660
 tgcccccgcc gcttccgcga ggcgggcgag ctggcgcacc accatcgcgt gcactcgggg    720
 gagcgcccgt accagtgccc catctgccgg ctgcgcttta cagaggccaa cacgctccgg    780
 cgccatgcga agcgcaagca cccggaggcc atgggggtac ccctgtgtgc accagatcca    840
 gggtctgaac cgccgtggga cgaggagggc atcccggcca cagcaggggc cgaggaagag    900
 gaggagacag aggggaaagg ggagccggcc tgacccacac ccccggccat cgctccctgg    960
 gccaggttta gagcagggag tttggctggt gctgggcctg agccaggggg ccgggacacc   1020
 cttgtttccg gtggtcttcc cgttgtggga gcaggtggag ggtggagacc taaactttgg   1080
 ggtccagctg ccttcagccc ccctccccca gactaacaga cccttggagg caggggctgt   1140
 ggaaataaat ctctgcctgc tggctgcctg tgtgtgttcc gtgccgggat gccatcctct   1200
 cctgccttca aatgttcttc ctcggctaca ccgtcctgtc gggagtgcgg ggaattgggg   1260
 aggaccccac ttgctgtgcc tcatgagcgt ggg                                1293



      <210> 1368
      <211> 5185
      <212> DNA
      <213> Homo sapiens


      <400> 1368
 ggtcgggagg acgagcaccg agtcgagggc tcgctcgtct gggccgcccg agagtcttaa     60
 tcgcgggcgc ttgggccgcc atcttagatg gcgggagtaa gaggaaaacg attgtgaggc    120
 gggaacggct ttctgctgcc ttttttgggc cccgaaaagg gtcagctggc cgggctttgg    180
 ggcgcgtgcc ctgaggcgcg gagcgcgttt gctacgatgc gggggctgct cggggctccg    240
 tcccctgggc tggggacgcg ccgaatgtga ccgcctcccg ctccctcacc cgccgcgggg    300
 aggaggagcg ggcgagaagc tgccgccgaa cgacaggacg ttggggcggc ctggctccct    360
 caggtttaag aattgtttaa gctgcatcaa tggagcacat acagggagct tggaagacga    420
 tcagcaatgg ttttggattc aaagatgccg tgtttgatgg ctccagctgc atctctccta    480
 caatagttca gcagtttggc tatcagcgcc gggcatcaga tgatggcaaa ctcacagatc    540
 cttctaagac aagcaacact atccgtgttt tcttgccgaa caagcaaaga acagtggtca    600
 atgtgcgaaa tggaatgagc ttgcatgact gccttatgaa agcactcaag gtgaggggcc    660
 tgcaaccaga gtgctgtgca gtgttcagac ttctccacga acacaaaggt aaaaaagcac    720
 gcttagattg gaatactgat gctgcgtctt tgattggaga agaacttcaa gtagatttcc    780
 tggatcatgt tcccctcaca acacacaact ttgctcggaa gacgttcctg aagcttgcct    840
 tctgtgacat ctgtcagaaa ttcctgctca atggatttcg atgtcagact tgtggctaca    900
 aatttcatga gcactgtagc accaaagtac ctactatgtg tgtggactgg agtaacatca    960
 gacaactctt attgtttcca aattccacta ttggtgatag tggagtccca gcactacctt   1020
 ctttgactat gcgtcgtatg cgagagtctg tttccaggat gcctgttagt tctcagcaca   1080
 gatattctac acctcacgcc ttcaccttta acacctccag tccctcatct gaaggttccc   1140
 tctcccagag gcagaggtcg acatccacac ctaatgtcca catggtcagc accaccctgc   1200
 ctgtggacag caggatgatt gaggatgcaa ttcgaagtca cagcgaatca gcctcacctt   1260
 cagccctgtc cagtagcccc aacaatctga gcccaacagg ctggtcacag ccgaaaaccc   1320
 ccgtgccagc acaaagagag cgggcaccag tatctgggac ccaggagaaa aacaaaatta   1380
 ggcctcgtgg acagagagat tcaagctatt attgggaaat agaagccagt gaagtgatgc   1440
 tgtccactcg gattgggtca ggctcttttg gaactgttta taagggtaaa tggcacggag   1500
 atgttgcagt aaagatccta aaggttgtcg acccaacccc agagcaattc caggccttca   1560
 ggaatgaggt ggctgttctg cgcaaaacac ggcatgtgaa cattctgctt ttcatggggt   1620
 acatgacaaa ggacaacctg gcaattgtga cccagtggtg cgagggcagc agcctctaca   1680
 aacacctgca tgtccaggag accaagtttc agatgttcca gctaattgac attgcccggc   1740
 agacggctca gggaatggac tatttgcatg caaagaacat catccataga gacatgaaat   1800
 ccaacaatat atttctccat gaaggcttaa cagtgaaaat tggagatttt ggtttggcaa   1860
 cagtaaagtc acgctggagt ggttctcagc aggttgaaca acctactggc tctgtcctct   1920
 ggatggcccc agaggtgatc cgaatgcagg ataacaaccc attcagtttc cagtcggatg   1980
 tctactccta tggcatcgta ttgtatgaac tgatgacggg ggagcttcct tattctcaca   2040
 tcaacaaccg agatcagatc atcttcatgg tgggccgagg atatgcctcc ccagatctta   2100
 gtaagctata taagaactgc cccaaagcaa tgaagaggct ggtagctgac tgtgtgaaga   2160
 aagtaaagga agagaggcct ctttttcccc agatcctgtc ttccattgag ctgctccaac   2220
 actctctacc gaagatcaac cggagcgctt ccgagccatc cttgcatcgg gcagcccaca   2280
 ctgaggatat caatgcttgc acgctgacca cgtccccgag gctgcctgtc ttctagttga   2340
 ctttgcacct gtcttcaggc tgccagggga ggaggagaag ccagcaggca ccacttttct   2400
 gctccctttc tccagaggca gaacacatgt tttcagagaa gctgctgcta aggaccttct   2460
 agactgctca cagggcctta acttcatgtt gccttctttt ctatcccttt gggccctggg   2520
 agaaggaagc catttgcagt gctggtgtgt cctgctccct ccccacattc cccatgctca   2580
 aggcccagcc ttctgtagat gcgcaagtgg atgttgatgg tagtacaaaa agcaggggcc   2640
 cagccccagc tgttggctac atgagtattt agaggaagta aggtagcagg cagtccagcc   2700
 ctgatgtgga gacacatggg attttggaaa tcagcttctg gaggaatgca tgtcacaggc   2760
 gggactttct tcagagagtg gtgcagcgcc agacattttg cacataaggc accaaacagc   2820
 ccaggactgc cgagactctg gccgcccgaa ggagcctgct ttggtactat ggaacttttc   2880
 ttaggggaca cgtcctcctt tcacagcttc taaggtgtcc agtgcattgg gatggttttc   2940
 caggcaaggc actcggccaa tccgcatctc agccctctca gggagcagtc ttccatcatg   3000
 ctgaattttg tcttccagga gctgccccta tggggcgggg ccgcagggcc agcctttgtg   3060
 ccagccttgt ttctctaaca aacaagggcc agccttgttt ctctaacaaa caaacaaaca   3120
 aacagccttg tttctctagt cacatcatgt gtatacaagg aagccaggaa tacaggtttt   3180
 cttgatgatt tgggttttaa ttttgttttt attgcacctg acaaaataca gttatctgat   3240
 ggtccctcaa ttatgttatt ttaataaaat aaattaaatt taggtgtaat ggctggctgt   3300
 tacctccttt taaagtaatt ctgagctcac aacttgaatg ccccatttgt tcaccctctt   3360
 caggagcaga attcaagaac aggaaatgtg cccagagcct aggctgggaa tgaatttgta   3420
 atttaacctt tgtactcttt gtaaacctct actgaagagt taagtataaa aattaattaa   3480
 gcagaaagta ctctaaactc agctaatacc ttaagtaata cattttataa actatttatt   3540
 tatttggtag gtacagcttt tttaaacaca aaaatagatt agataaattc cagcttggaa   3600
 caagctagtg ctggttcaca aggttatgct cacccttcaa ttaaaatcaa aatgactaca   3660
 agacttgcca tcagctctct tcaggaccac tgctgggtca gaatcagaaa ccttgggtgc   3720
 catgaaattt ttacaaaatt tcaaatcaaa gccaggcttt gcagctagat aatagatcac   3780
 ttgagtacga accacacatg taagtgcacg tatatttgag ttctcaatac aattaccctg   3840
 atgggcaaga acccacaggt gagagcagag gcttggttcc cctagagggc cctggctgga   3900
 ggccccaaca ccaaccagac gacaggaggg ccagactgct acccagtact gtacctcctg   3960
 ctccttcaag agcctcccta agggagaaga agatctatac ttccactttg tttgctgcac   4020
 atgtggcaac aagattgcta ccctgatttg ggacacttga gagaacttga aaaaaatgac   4080
 cacccttaaa gccctagaaa aaagttgtat gtttgttaac agctatgctg cgctcacttt   4140
 gcattgtgtg ttcttgaaag ctctgtataa atcaaaattt tgacgacaca ctaaatacac   4200
 tagagaaata cactatagag gaatcctttt atagggctga agactccttt ggtaagaaaa   4260
 atatgctgca ttaggggcag ctgcaagttt actatttctg gggaagaaaa gatcaaagat   4320
 aagagccagg tttgtttttt aaagcaatca atccaaacag tttgggtgtt tgttagttgt   4380
 tacccctgag gggcttgagg tgtaactata tcagctataa aaatagcaat tccatacatt   4440
 taattaggtt actttatatc tttcactctt ccccatggct gtaataatgg agattgaatg   4500
 agactaaggc taagcgcaac tccactcaaa tccaagtcac acgtcacctt gggctgcagt   4560
 acagggaagc tccgcacacc ctggcttggg aaagtttcgg ccgatggagc ccaagatgca   4620
 gggcaaccat ctaactcttt agggttctga tgaattccca ctccagaaag gtgcatgaaa   4680
 gaggtccccg agctctgtca tgtcgacatc ttcattgttg gggacatgcc ggctttctcg   4740
 gttctcgatg aaatcccaga gccgcacttg aattaaagaa cctcacagtg gccttgagaa   4800
 cttgagctgt ttccgaggtt tctcaggctc tgctaagccg cccatcgggg taagcatggc   4860
 gataaagaca tttgcttcca aatgggcagg tccccttgcc ttgctcaaag tatttacagg   4920
 cttttttccc catcccctgg tttgaaagct tcaatcaact cgttcttttt attctgatct   4980
 tccacccaat acacacttgg aattacaaac tctgatatca cacggcattc tggacaagac   5040
 ttaatgattg ggttttcaaa ctgtttggca caccgccact gccggatgca ggacaaacag   5100
 tacgtgtgat tgcaattgga gagaatccca aatctcctct cagaagcaga ggccttctcc   5160
 aggatcactt ccatgcagat actgc                                         5185



      <210> 1369
      <211> 918
      <212> DNA
      <213> Homo sapiens


      <400> 1369
 agccgacacc ctttacagtc aaattaaaga agatgtcaaa aagcgtgctg tggcactgga     60
 tgaagccatt tctcaatcaa ctcagttcca tgacaagata gatcagatcc ttgagagcct    120
 ggaacgcatc gtggaacgtc tgaggcagcc accctctatc tctgcagagg ttgagaagat    180
 caaggaacag atcagtgaaa ataagaatgt gtcagtagac atggaaaagc tacagccgtt    240
 gtatgaaact cttaaacaga ggggagagga aatgattgct agatctgggg ggactgataa    300
 agacatatct gccaaagctg ttcaggataa gcttgaccaa atggttttca tttgggagaa    360
 catacacaca ctggtggaag agagggaagc caaactactg gatgtgatgg agctagcaga    420
 aaagttctgg tgtgatcaca tgtcattgat agttaccatt aaagatactc aagatttcat    480
 ccgggacctg gaagatcctg gaattgatcc ttcagtagta aaacaacagc aagaagcagc    540
 agagaccata agggaagaaa tagatggact acaggaggag ctggatatag ttattaacct    600
 aggttctgaa ctcattgcgg catgtgggga gcctgataaa cccattgtca agaagagtat    660
 agatgagtta aattcagcat gggattctct aaataaagct tggaaagacc ggattgacaa    720
 acttgaggag gcaatgcagg ctgccgttca gtaccaggat ggactgcagg cggtatttga    780
 ctgggtagat attgcaggtg gtaaattagc ttcaatgtct ccaattggaa cagatctcga    840
 aactgtcaag cagcagattg aagagctaaa gcaatttaag tctgaggcct atcaacagca    900
 gatagaaatg gaaagact                                                  918



      <210> 1370
      <211> 529
      <212> DNA
      <213> Homo sapiens


      <400> 1370
 gcacgaggcg acttctccct caccctgcgg cgtcatcact gtcacgcctg tggcaagatc     60
 gtgtgccgga actgttcgcg gaacaagtac ccgctgaagt acctgaagga caggatggcc    120
 aaggtctgcg acggctgctt cggggagctg aagaagcggg gcagggctgt cccgggcctg    180
 atgagagagc ggcctgtgag catgagcttc ccgctgtctt caccccgctt ctcgggcagt    240
 gccttttcat ccgtcttcca gagcattaac ccctcgacct tcaagaagca gaagaaagtc    300
 ccttcagccc tgacagaggt aaagcaggca gggctaccca agtgggaagt agggcatttg    360
 gaaggttcat ggtcatcctg ggtagacgga gtcagaccct gccctgtccc agcctgacca    420
 gtctcttcca gacagagcat tcctaatgga agcatcccag ctacgaggac cgacttgaca    480
 gtgatggtgc taggcgacat ctttcccatc cttctctcta actcttccc                529



      <210> 1371
      <211> 841
      <212> DNA
      <213> Homo sapiens


      <400> 1371
 ctgacgattt cggcacgagg gatacttcag tagtgtgaat aagccatctg acgaggtgtc     60
 cttttactag aaacgcacat ctgttactcc acatcagaga cttcattttg ttgataaacc    120
 ctatgaatgt aaggaatgtg ggaaggcgtt cagagtgcgc caacagctta cttttcatca    180
 cagaattcat actggtgaaa aaccgtatga atgtaaggaa tgtgggatgg ccttcagaca    240
 gactgcacac cttactcgac atcagagact tcattctggt gaaaaactct atgaatgtaa    300
 ggaatgtggg gaagctttca tatgtggtgc agatcttaga gtacatcaga aaatgcatat    360
 tggtgagaag ccctatgaat gtaaagaatg tgggaaggct tttagggtac gaggacaact    420
 tactctgcat cagaggattc atactggtga gaaaccctat gtgtgtaaag agtgtggaaa    480
 agcctttaga cagtacgcac acctgactcg gcatcagaag cttaatagtg ctgacaggct    540
 ctatgaatgc aaagaatgtg ggaaggcctt tttgtgtggc tctggtctta gagtacatca    600
 caaacttcat actggtgaga aaccctatga atgtaaggaa tgcgggaagg cctttagagt    660
 gcgacaacaa ctaacactcc atcagagaat tcatactggt gagaaaccct atgaatgtaa    720
 ggaatgtgga aagaccttta gccgtggcta tcatcttatt ctccatcaca gaattcatac    780
 tgggtgaaaa ccttacgaat gtaaggaatg ctggaaagcc tttagtcgct actcacaact    840
 t                                                                    841



      <210> 1372
      <211> 3050
      <212> DNA
      <213> Homo sapiens


      <400> 1372
 cggacgcgtg gggctgtaag cttcggcgcc tccgcttcac ctatgggact cagactcggg     60
 tcagcctggc gctccctgga cagtatgaac tagtgcacac gctggttgct catcagggca    120
 actgggagac catccctgag gaggatctgg aggtccaaga gaacaatgag gatgctgctc    180
 atgatttaac ggaactggag gtaacgatgc accatgctct cttacaggaa gtggacgttg    240
 tggtagcacc atgccaaggc ctccggccca cagtggatgt tctgggtgac ttggtgaatg    300
 atttcttgcc tgtgataacc tatgcactcc acaaagatga actctctgag agggatgagc    360
 aagagcttca ggaaatccga aagtatttct cctttcctgt attctttttc aaagtgccga    420
 aactgggctc ggagataata gactcctcaa ccaggagaat ggagagcgaa agatcaccgc    480
 tttatcgcca gctaattgac ctgggctatc tgagcagcag tcactggaac tgtggggctc    540
 ctggccagga tactaaagct cagagcatgt tggtggaaca gagtgaaaag ctgagacact    600
 tgagcacatt ttctcaccag gtgttacaga ctcgcctggt ggatgcagcc aaggccctga    660
 acctggtgca ctgccactgc cttgacatct ttattaacca ggcatttgac atgcagcggg    720
 acctgcagat cactcccaaa cgtctggaat atactcgaaa aaaggagaat gagttgtatg    780
 aatcattgat gaatattgcc aaccgaaagc aggaggaaat gaaggatatg attgttgaga    840
 cacttaatac catgaaggag gaacttctgg atgatgctac taacatggag tttaaagacg    900
 tcattgtccc tgagaatgga gaaccagtag gcaccagaga gatcaaatgc tgcatccgac    960
 agatccagga actcatcatc tcccgactta atcaggcagt ggctaataag ctgatcagct   1020
 cagtggatta cctgagggaa agcttcgtcg gaaccctgga acgatgtctg cagagcctgg   1080
 agaagtctca ggatgtctca gttcacatca ccagtaatta tctcaaacag atcttaaatg   1140
 ctgcctatca tgttgaagtc acgtttcact cagggtcgtc agttacaagg atgctatggg   1200
 agcaaatcaa acagatcatc cagcgcatca catgggtgag cccacctgcc atcactctgg   1260
 aatggaagag gaaggtggcc caggaagcca ttgagagcct cagcgcctcc aaattggcta   1320
 agagcatttg cagccaattc cggactcggc tcaatagttc ccacgaggct tttgcagcct   1380
 ccttgcggca gctggaagct ggccactcag gccggttaga gaaaacggaa gatctatggc   1440
 tgagggttcg gaaagatcat gctccccgcc tggcccgcct ttctctggaa agccgttctt   1500
 tacaggatgt cttgcttcat cgtaaaccta aactgggaca ggaactgggc cggggccagt   1560
 atggtgtggt atacctgtgt gacaactggg gaggacactt cccttgtgcc ctcaaatcag   1620
 ttgtccctcc agatgagaag cactggaatg atctggcttt ggaatttcac tatatgaggt   1680
 ctctgccgaa gcatgagcga ttggtggatc tccatggttc agtcattgac tacaactatg   1740
 gtggtggctc cagcattgct gtgctcctca ttatggagcg gctacaccgg gatctctaca   1800
 cagggctgaa ggctgggctg accctggaga cacgtttgca gatagcacta gatgtggtgg   1860
 agggaatccg cttcctgcac agccagggac ttgtccatcg tgatatcaaa ctgaaaaatg   1920
 tgctgctgga taagcagaac cgtgccaaga tcactgactt aggattctgc aagccagagg   1980
 ccatgatgtc aggcagcatt gtggggacac caatccatat ggcccctgaa cttttcacag   2040
 ggaagtacga taattccgtg gatgtctacg cttttggaat tcttttctgg tatatctgct   2100
 caggctctgt caagctccct gaggcatttg agaggtgtgc tagcaaagac catctctgga   2160
 acaatgtgcg gaggggggct cgcccagaac gtcttcctgt gtttgatgag gagtgctggc   2220
 agttgatgga agcctgttgg gatggcgacc ccttgaagag gcctctcttg ggcattgtcc   2280
 agcccatgct ccagggcatc atgaatcggc tctgcaagtc caaattctga gcagccaaac   2340
 agaggactag atgattctac ttgaaagcaa agaccctttc ctctttcact ctcctagtta   2400
 tttcccttcc ccctcacctt ttggcccatg gggagaattt gacatttatt cactatagga   2460
 cacaactccc aagggaactg gtgcttgctg ggaaacttgg aaccttccca ggcagggatg   2520
 actcctggac agtgaagagt tgaatgactg agcatattca gcagctcact gaagcgccaa   2580
 gctatccctt tagcaaaaaa gtgtctcaga tgtgtaaaag ctgaggaatg tggtgttctg   2640
 gcttcacaaa tgaaaaggag gcagatgtta ccattgtctt ttcactgtat atacttctaa   2700
 gacagcaagc gggacactgc agtggcaata gtgttaaaaa atctcattct catgattttt   2760
 ggctctagct aggaatagtt tagtcaggac tcagaaaatt tgagcttagt tctgggatta   2820
 tgaaaacatg gggacaaaaa caataacttg tggatgtctg gttcctgctg tctgcagcca   2880
 ggtatctcag gttgcaatgg tcagaagtcc cagtgaggga gctagaaaca gagctatctg   2940
 ttcctcatag tgccagtgtg tttacattta taggaccaca tatccctggt ttctggggga   3000
 gggtttcact gttacatcac caagaggccc tgaaaagagg aaaaaaaaaa              3050



      <210> 1373
      <211> 3289
      <212> DNA
      <213> Homo sapiens


      <400> 1373
 gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta     60
 ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt    120
 cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc    180
 cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca    240
 acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc    300
 cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg    360
 acatgattac gaatttaata cgactcacta tagggaattt ggccctcgag gccaagaatt    420
 cggcacgagg tttttttttt tttaagtggg acaattaaaa atttaaaaaa taattttaaa    480
 atagaacagc ttagagatag gaaacctaaa tttatttccc aattccttac tgtgccccca    540
 aaaccagggt tcaccaaaag ggctgtcctc ccaacaattt tctgaattct atatattcag    600
 cattaaattc catgataaag ttggaaatcc attcaccatt tgtaatacat attgatgcat    660
 ttaataaaat tgcatgggcc gtatcttttg catttctgta tcctagtatt aagtacagtg    720
 cctaccacag gccaggttct caatacttga ataaatgaca caaaaatagc caggaccagc    780
 aagttttttc tgggtgggct tcatagaatc tctgtacttg ctggaatcac catgaaatcc    840
 atggtcttca gctttgcatt ttcagcaaca tagttatatt gagttatcct caggtgagca    900
 gtgagaccct tgggagcgga ttcatggtag ggtggctttg taatgtgtca ccttggtgag    960
 gctatgtttc ccggaactct cttccagtaa gatgggccac aagagacatt ttgcttgata   1020
 accggagggc ggaagtgaag cagcagcaca ttgtttttac acttggaagg ttggtgctgg   1080
 ggcaccaggc gttgttgcag ttcacacgtt gccatgtatc tgctagatca cctcgttggt   1140
 gtgggcagta gtcaggcctg cagccaggcc tgcagctgct ccaccttccc caggatcatc   1200
 ctttcagctt ctctaattcc tgggccagat gcatatttaa ctctgtgagg aagggcacca   1260
 gcttcttctg caggacaccc acatcatcga agctggaggt ggtgagagac tgacatgggt   1320
 tccaggccat cctcgtgggt tccagctcgt gctcgtgggc tccactgtgt cctcggtctc   1380
 ccacacttta catccatctt cccttcccga gtgcctgccc tgcagacttg aatcctacag   1440
 tctgtagaag cctccagtca actgctttct agctccaggt tttttaaggt ctttggacct   1500
 tggcaaccag actgctgtat ctcggaagcg ggttccaccc aggctgaaaa tctccgtgat   1560
 cacgggtgtg ccagcccctc ctgcctcttc ctctggggcc aatttggagg cagaatcatc   1620
 cttgttctcc tccttgtcct cctctgggtc aggtggctct tgcttcacag aaggcaggcc   1680
 tgggtctact gccttgctag ggcagccagg caccaatacg ggagaagtca ggacagctgt   1740
 gcctggtgtc cactcgtcct gggtatccgc cttctcttgc ttcacctggg gtaaggccac   1800
 aacccaactc atgccagaac actgggcytc ctgcaacagg gcttctgtgg aagctgcaac   1860
 agggcccggc acctgcacag gamtgcttgc gcccttcccg taaaaaacac aaggttcagt   1920
 gcccaggcgg gggcagcaca aagccaccac ctgcttcctg cttcgttgga gcctgggtat   1980
 ggtctggttg ggctgtgcgt gtagccaagg tgggcttcaa ggtagggcca agatggtgcc   2040
 gtcgggcaga gctgggcctc tttcgacgac ggtaaggtgg gggcgatcct gccccatcct   2100
 cagactctga ccagacactg ggcagcagcc gcttcatggc aaactgcagg cattggcgcc   2160
 aacgacactt ctggcgcttc tggttgctgc ccccgaattt gggcttgtcg cagcagaagt   2220
 cgcagcggcc acatccattc cgccgtaggc aggctgcaca ggccccgcac ttgcggttct   2280
 gccggcggtt cgtgtagggc tgtagctcgt cctcgtctac acagtaatag atgaactcgg   2340
 caggtggcga gggggccagg gctctggggt gcggctctgt gggctctggg gactgtgatg   2400
 ggggtggtgg aggcagtggc tgggctccgg ggcgccgcct ggcagccatc ttggagtcac   2460
 agcctccctt gcggcgggca tgtttacccc gtaggcaacg tcgctggaca catttccact   2520
 ggcgcctgag accagggcgg ggagggcgaa ggcagatggg gcaatggcca caatcytctt   2580
 gggtctgaca gccccggcat actccacacc ctcggctctt aaacattctc tgttcccggt   2640
 tgaaggcaat tctctgtgct cgacagtctt tgcacaacgt tttgagccgc tgcctttggg   2700
 tgccatcccc tgagaagctg attccacagt tctcacagca cccaggagca gggaatgaag   2760
 ctggggctgt gtcagtgtca gccttggtct catccctcgg ggcctccttc ctgacctcac   2820
 cactctgggg tccaacctga cgtttccgag tcttggctgg ccttgaaggc ttctttcgct   2880
 tcttgctggc aaccgccacg ggatgggcct tgggggctgg atagcacaag atgccttgtt   2940
 tgaagtcgaa gagggtgaga tcacacgcag ggcccaggta tcgagtcagc tcaactttgc   3000
 ttcggatcct gtctcctgtg gggctctggt aataggtgtc tgagcgtcca caggtggccc   3060
 ctgacttgcg aaagacttcg cggcgcttcc agccagggcc cagggccggg cagtccagcc   3120
 agtcctcagc catggaggcc acaggaagca gcagtagcca gtttggcacc aggccggtat   3180
 cttccgccac tctaggcccg tggacccatg gcgagggtcc ctcctgcacc tcccgcctcg   3240
 ccctcctccc cttcctcctc ctccgcggcc ggggggagta tcacacaaa               3289



      <210> 1374
      <211> 3128
      <212> DNA
      <213> Homo sapiens


      <400> 1374
 agcggccgcc cttttttttt ttttttcatt tcattcaaga gaattaaatc gtttattgat     60
 tacacatgat aatggataca caagcttcat tcccatctat aattttatct ggtaccatta    120
 ttcaatttag atatattgca taggatgtgc caacaatcac ttttataacc attccatgat    180
 tttgcttggg taatcccttt taatggtgaa cttcaggtca caacagtaac tatcagttca    240
 actacaccaa ggtttccgaa gacaatggct tctccaccca agcaggttgt atataaattc    300
 caaatagaac ctggcatcac cctgaaggaa ttctaacttc acactgttgg ggaaatttac    360
 caagatggct taagagtaga ctaactttac acagcacatt aaaaaaaaga catttattca    420
 gcgtcacgat cagactgtta catttagcaa tcaacagcat ggggtgcaaa aaaaaaaaat    480
 ctacattaaa accctttgtt ggaatgcttt acactttcca cagaacagaa actaaaataa    540
 cctgttatac aattagtcac aaatacagtc ctcgagtttt ttgcccatac acatgagtat    600
 ttgtctaaaa catgtcttct ttgtagcagc taggccctgc caccactgtg cttggctgag    660
 ttcacaaatc tgttgtaacc tgtagcttcc ctgtcacttc tctggctctc ctctcctgct    720
 aagctttgtt tcctaattaa aatcttctgc cactgccata gctactgctg ctgctggaac    780
 cgccatagcc accttggttt cgtggttttg caaagtattg gcctccaccg ccataggggc    840
 cagagcttct gcctccaaaa tttcctccct tcatgggtcc aaaatttgaa gactgattgt    900
 tgtaattccc aaaatcattg tagcttccac cacctccaaa attgcttcca tcattaccaa    960
 atccattata gccatcccca ctgccaccat atccaccacc caccacgggt ggcacccaaa   1020
 gccaaccaag gaccaactga agtttcctcc acggaccgaa gttgtccatt cccaccgaaa   1080
 accacctccc acgacccacc accaaaagtt tccaagaacc acttcgaccc tcctttgggc   1140
 tggatgaaag cactagccat ctcttgcctt tgaacagggc ttttctaaac ttcacaggtt   1200
 gtggcccatt cacagtatgg taattcctga aatggacaat cttatcccac ggagtccatg   1260
 gtccgtccaa aggttacaaa aggcaaagcc cctttttctt ggccactggc ctccggtcca   1320
 gtcaatggat ttcaatcaac ttcaaatttt tccaatactt gttcaaaata atctcttagg   1380
 tgaatgttct ttcaggggtc ttctttaatg ccaaccaaac aaaatatctt ttttcacaag   1440
 ttaatgtggg cacctgggtc ttttgagaaa tcttcctctg gaagacaagc tcctctttgg   1500
 gttcccacaa ctccttacca tcccaccttt gtgtggcctt tgcattcata gctgcatcca   1560
 cctcctccac acgtggcata tgtgacaaac ccaaagcccc ttggagcgct tggtggtttg   1620
 ggatctctca ttaccacaca ggtccgtgda gcgtttcccc cattgcctcg aaaatggctc   1680
 ctcagggctc tcatcatgtt gtttcaaagc tcraaccctc mgaatgaaga gcttcctcag   1740
 ctgttcgggg ctctttagga gactctgccc gtggacgccg ccgaagaagc atcgttaaag   1800
 tctctcttca ccctgccgtc atgtctaagt cagagtctcc taaagagccc gaacagctga   1860
 ggaagctctt cattggaggg ttgagctttg aaacaactga tgagagcctg aggagccatt   1920
 ttgagcaatg gggaacgctc acggactgtg tggtaatgag agatccaaac accaagcgct   1980
 ccaggggctt tgggtttgtc acatatgcca ctgtggagga ggtggatgca gctatgaatg   2040
 caaggccaca caaggtggat ggaagagttg tggaaccaaa gagagctgtc tccagagaag   2100
 attctcaaag accaggtgcc cacttaactg tgaaaaagat atttgttggt ggcattaaag   2160
 aagacactga agaacatcac ctaagagatt attttgaaca gtatggaaaa attgaagtga   2220
 ttgaaatcat gactgaccga ggcagtggca agaaaagggg ctttgccttt gtaacctttg   2280
 acgaccatga ctccgtggat aagattgtca ttcagaaata ccatactgtg aatggccaca   2340
 actgtgaagt tagaaaagcc ctgtcaaagc aagagatggc tagtgcttca tccagccaaa   2400
 gaggtcgaag tggttctgga aactttggtg gtggtcgtgg aggtggtttc ggtgggaatg   2460
 acaacttcgg tcgtggagga aacttcagtg gtcgtggtgg ctttggtggc agccgtggtg   2520
 gtggtggata tggtggcagt ggggatggct ataatggatt tggtaatgat ggaagcaatt   2580
 ttggaggtgg tggaagctac aatgattttg ggaattacaa caatcagtct tcaaattttg   2640
 gacccatgaa gggaggaaat tttggaggca gaagctctgg cccctatggc ggtggaggcc   2700
 aatactttgc aaaaccacga aaccaaggtg gctatggcgg ttccagcagc agcagtagct   2760
 atggcagtgg cagaagattt taattaggaa acaaagctta gcaggagagg agagccagag   2820
 aagtgacagg gaagctacag gttacaacag atttgtgaac tcagccaagc acagtggtgg   2880
 cagggcctag ctgctacaaa gaagacatgt tttagacaaa tactcatgtg tatgggcaaa   2940
 aaactcgagg actgtatttg tgactaattg tataacaggt tattttagtt tctgttctgt   3000
 ggaaagtgta aagcattcca acaaagggtt ttaatgtaga tttttttttt tgccccccat   3060
 gctgttgatt gctaaatgta acagtctgat cgtgacgctg aataaatgtc ttttttttaa   3120
 aaaaaaaa                                                            3128



      <210> 1375
      <211> 693
      <212> DNA
      <213> Homo sapiens


      <400> 1375
 ccatattgta tttgttgtgc atggcattgg gcagaaaatg gaccaaggaa gaattatcaa     60
 aaatacagct atgatgagag aagctgcaag aaaaatagaa gaaaggcatt tttccaacca    120
 tgcaacacat gttgaatttc tgcctgttga gtggcggtca aaacttactc ttgatggaga    180
 cactgttgat tccattactc ctgacaaagt acgaggttta agggatatgc tgaacagcag    240
 tgcaatggac ataatgtatt atactagtcc actttataga gatgaactag ttaaaggcct    300
 tcagcaagag ctgaatcgat tgtattccct tttctgttct cggaatccag actttgaaga    360
 aaaagggggt aaagtctcaa tagtatcaca ttccttggga tgtgtaatta cttatgacat    420
 aatgactggc tggaatccag ttcggctgta tgaacagttg ctgcaaaagg aagaagagtt    480
 gcctgatgaa cgatggatga gctatgaaga acgacatctt cttgatgaac tctatataac    540
 aaaacgacgg ctgaaggaaa tagaagaacg gcttcacgga ttgaaagcat catctatgac    600
 acaaacacct gccttaaaat ttaaggttga gaatttcttc tgtatggggt ccccattagc    660
 agttttcttt gcgttgcgtg gcatccgccc agg                                 693



      <210> 1376
      <211> 354
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(354)
      <223> n = a,t,c or g


      <400> 1376
 agtaaatata gctcttcata attttgttct gaagtttaaa aatatatata tttttgaatg     60
 gataactttc tttttctaaa tgcttacagt agagcccacg atggttgtta aaagccccca    120
 ggttcagcct tctttaattg tgtggtcagc ctgccatcaa cccaggggct ccctctgctc    180
 ggcactgtnc tgctctagtg aatacctttt ttattctggt gtgacctaat atggccggta    240
 aggcggtcac ttctcataga gcgttgtgaa cattctggac aaacaaattt cttctcaccc    300
 tgtatgcgct cttctgtgcc tctgtaattc atcacttcga gtaaatcttt tacc          354



      <210> 1377
      <211> 2720
      <212> DNA
      <213> Homo sapiens


      <400> 1377
 ccggaaactc gggtcgaccc acgcgtccgc gcgaggggcg gggcgagcgc gggacaaagg     60
 gaagcgaagc cggagctgcg ggcgcttttt ctgcccgcgg tgtctcagat tcattcttaa    120
 ggaactgaga acttaatctt ccaaaatgtc aaaaagacca tcttatgccc cacctcccac    180
 cccagctcct gcaacacaaa tgcccagcac accagggttt gtgggataca atccatacag    240
 tcatctcgcc tacaacaact acaggctggg agggaacccg ggcaccaaca gccgggtcac    300
 ggcatcctct ggtatcacga ttccaaaacc cccaaagcca ccagataagc cgctgatgcc    360
 ctacatgagg tacagcagaa aggtctggga ccaagtaaag gcttccaacc ctgacctaaa    420
 gttgtgggag attggcaaga ttattggtgg catgtggcga gatctcactg atgaagaaaa    480
 acaagaatat ttaaacgaat acgaagcaga aaagatagag tacaatgaat ctatgaaggc    540
 ctatcataat tcccccgcgt accttgctta cataaatgca aaaagtcgtg cagaagctgc    600
 tttagaggaa gaaagtcgac agagacaatc tcgcatggag aaaggagaac cgtacatgag    660
 cattcagcct gctgaagatc cagatgatta tgatgatggc ttttcaatga agcatacagc    720
 caccgcccgt ttccagagaa accaccgcct catcagtgaa attcttagtg agagtgtggt    780
 gccagacgtt cggtcagttg tcacaacagc tagaatgcag gtcctcaaac ggcaggtcca    840
 gtccttaatg gttcatcagc gaaaactaga agctgaactt cttcaaatag aggaacgaca    900
 ccaggagaag aagaggaaat tcctggaaag cacagattca tttaacaatg aacttaaaag    960
 gttgtgcggt ctgaaagtag aagtggatat ggagaaaatt gcagctgaga ttgcacaggc   1020
 agaggaacag gcccgcaaaa ggcaggagga aagggagaag gaggccgcag agcaagctga   1080
 gcgcagtcag agcagcatcg ttcctgagga agaacaagca gctaacaaag gcgaggagaa   1140
 gaaagacgac gagaacattc cgatggagac agaggagaca caccttgaag aaacaacaga   1200
 gagccaacag aatggtgaag aaggcacgtc tactcctgag gacaaggaga gtgggcagga   1260
 gggggtcgac agtatggcag aggaaggaac cagtgatagt aacactggct cggagagcaa   1320
 cagtgcaaca gtggaggagc caccaacaga tcccatacca gaagatgaga aaaaagaata   1380
 agtgttgcct tgttttgtgt gttctaaata ctttttttaa tgaaaaaatg ttttttggtt   1440
 ttaatggtgt tacgtggttt gtgtattaat tttttttctt gtccatatca caccaccaaa   1500
 ggcttttgga ccatttagca tcatgagcct aatggctcag tcagtcacct ttcttaagtg   1560
 ttgtgaagat ggctcttttc tttggatctt gtttctagcc ctcaactgct gaaagcctca   1620
 gaatttagat taattgagaa aacacccacc tcttttagag aattatcctt tgatgctgca   1680
 gaatctactc ttacaatgcc ttcctacagc tcactggggt gcttaccaaa gccatagctt   1740
 taaaccttcc cagtccccat cagtagcttc ctgaaagtct cctctcttgt ttacttctgc   1800
 aaagggtagc ttcttaaaaa cgtgatcatg tatgagtatg tatttgttca cttacccttt   1860
 tttactttta atcaatgtca gataccaaga gttgtgttaa gctgagtgta gtgtgtaact   1920
 aactacactt ggatcttact gatccagaaa tagtccccat agttagagta gttacttatg   1980
 aagtggttat taaagtgaac acagcacata tacattatct atactgcttt ttgttatgat   2040
 taatactggg tatgttctgg taaatccatc cttattgtat agaaaaaaaa ttactttttt   2100
 accaggtttt ccaaagacag aatagatcac aaagctcaag gaatttaata ttcttgtaat   2160
 ggactagata attcaaactg attagcccat tccagaagaa aaacagctgg gaattaagtt   2220
 aatccacttg aaattgtttt acaataatca gaacatccaa acctcaaggc tcaggatccc   2280
 atagaccaga gcccaccttt ttgataaact tagtaaagtc ttggagacta gaagcaagat   2340
 agtttgtgac acataagctt cccaaaaact agaatagatt tttactgaat agtggtatat   2400
 ctgatggtat atgtttctta aaggtccaaa tgtaataaaa aaaaaatgaa aaaaaggtct   2460
 cagtgttttt aatgcactac atatttgtat gcaagacaag catccagttt ttttctgtaa   2520
 tgcagtgaca gtgtggaatg accactcagc cattataaat ttgtgtactc agggcccttg   2580
 tctcacccaa ctatctctat aaactgctgc agtagcttat ttgtacaaga cacttgtgaa   2640
 aattagtttt cttacattat agtcattgtc acatatggaa gttggtcttt gattccaaaa   2700
 gtaaagggaa tatgtttcta                                               2720



      <210> 1378
      <211> 1145
      <212> DNA
      <213> Homo sapiens


      <400> 1378
 aaagattctg ttttgaatat agccagagga aaaaagtatg gagaaaaaac taagagagtg     60
 tcttctcgga aaaaaccagc cttgaagtgt cttctcagaa acaaccagca ttgaaggcta    120
 tctgtgacaa ggaagattct gttccgaata cggccacgga aaaaaaggat gaacaaatat    180
 ctgggacagt gtcttctcag aaacaaccag ccttgaaggc tacaagtgac aagaaagatt    240
 ctgtttcgaa tatacccaca gaaataaagg atggacaaca atctggaaca gtgtcttctc    300
 agaaacaacc ggcctggaag gctacaagtg tcaagaaaga ttctgtttcg aatatagcca    360
 cagaaataaa ggatggacaa ataccgtggg acagtgtctt ctcagagaca accagccttg    420
 aaggcttaca ggtgatgaga aagattctgt ttcgaatata gccagagaaa taaaggatgg    480
 agaaaaatct gggacagtgt ctcctcagaa acaatcggcc cagaaggtta tatttaaaaa    540
 gaaagtttct cttttgaata ttgccacaag aataacgggc ggttggaaat ctggaacaga    600
 gtatcctgag aatctgccca ccttgaaggc tacaattgaa aataaaaatt ctgttctgaa    660
 tacagccacc aaaatgaaag atgtacaaac atccacacca gaacaagact tagaaatggc    720
 atcagaggga gagcaaaaga ggcttgaaga atatgaaaat aaccagccac aggtgaaaaa    780
 ccaaatacat tctagggatg accttgatga cataattcag tcatctcaaa cagtctcaga    840
 ggacggtgac tcgctttgct gtaattgtaa gaatgtcata ttactcattg atcaacatga    900
 aatgaagtgt aaagattgtg ttcacctatt gaaaattaaa aagacatttt gtttatgtaa    960
 aagattaaca gaacttaaag ataatcactg tgagcaactt agagtaaaaa ttcgaaaact   1020
 gaaaaataag gctagtgtac tacaaaagag actatctgaa aaagaagaaa taaaatcgca   1080
 gttaaagcat gaaacacttg aattggaaaa agaactctgt agtttgagat ttgccataca   1140
 gcaag                                                               1145



      <210> 1379
      <211> 1145
      <212> DNA
      <213> Homo sapiens


      <400> 1379
 aaagattctg ttttgaatat agccagagga aaaaagtatg gagaaaaaac taagagagtg     60
 tcttctcgga aaaaaccagc cttgaagtgt cttctcagaa acaaccagca ttgaaggcta    120
 tctgtgacaa ggaagattct gttccgaata cggccacgga aaaaaaggat gaacaaatat    180
 ctgggacagt gtcttctcag aaacaaccag ccttgaaggc tacaagtgac aagaaagatt    240
 ctgtttcgaa tatacccaca gaaataaagg atggacaaca atctggaaca gtgtcttctc    300
 agaaacaacc ggcctggaag gctacaagtg tcaagaaaga ttctgtttcg aatatagcca    360
 cagaaataaa ggatggacaa ataccgtggg acagtgtctt ctcagagaca accagccttg    420
 aaggcttaca ggtgatgaga aagattctgt ttcgaatata gccagagaaa taaaggatgg    480
 agaaaaatct gggacagtgt ctcctcagaa acaatcggcc cagaaggtta tatttaaaaa    540
 gaaagtttct cttttgaata ttgccacaag aataacgggc ggttggaaat ctggaacaga    600
 gtatcctgag aatctgccca ccttgaaggc tacaattgaa aataaaaatt ctgttctgaa    660
 tacagccacc aaaatgaaag atgtacaaac atccacacca gaacaagact tagaaatggc    720
 atcagaggga gagcaaaaga ggcttgaaga atatgaaaat aaccagccac aggtgaaaaa    780
 ccaaatacat tctagggatg accttgatga cataattcag tcatctcaaa cagtctcaga    840
 ggacggtgac tcgctttgct gtaattgtaa gaatgtcata ttactcattg atcaacatga    900
 aatgaagtgt aaagattgtg ttcacctatt gaaaattaaa aagacatttt gtttatgtaa    960
 aagattaaca gaacttaaag ataatcactg tgagcaactt agagtaaaaa ttcgaaaact   1020
 gaaaaataag gctagtgtac tacaaaagag actatctgaa aaagaagaaa taaaatcgca   1080
 gttaaagcat gaaacacttg aattggaaaa agaactctgt agtttgagat ttgccataca   1140
 gcaag                                                               1145



      <210> 1380
      <211> 406
      <212> DNA
      <213> Homo sapiens


      <400> 1380
 ggcacgagga caatggtgtt tggaggaaag ggaagggggt ggggcggcct ccgtccttta     60
 gtcctgatca aggtgaggag atgcaagtcc attaaaaaaa catttgcttc caaccagact    120
 cctttctcag tggtgccggt cccgttctct atcccggtgt ctctcatgct cccggttcct    180
 ttcttggaaa taatcatcat gccgatcttc attatgaagc agatcccggt gcctcctgct    240
 gctctcccgg gaccggctag gtgacctttc ccgggagcga tgtcttttcc tggaagagct    300
 cccactggca cccacactgt aggacttggc ttcaatgcca tgaagacagt ccttaagaga    360
 ggagatgagg acacggcaac gctcatcatt ggcaacccgg gtattt                   406



      <210> 1381
      <211> 720
      <212> DNA
      <213> Homo sapiens


      <400> 1381
 ggcacgaggt ttgatgttga atttgttgat gaaggaagca cttcaatgga tctctttgaa     60
 gcatggaaga aggaatataa gttgcttcat gaatattgga tggctctgag gaatcgtgtg    120
 tctgctgttg atgaacttgc aatggctaca gaacgactaa gagtgcgtga tcctagggag    180
 ccaaagccta atccgcctgt tcttcatatc attgaaccac atgaggtaga acaaaaccga    240
 ataaaactac taaatgataa agctgttgct acatcacagc ttcagaaaaa acttgggcag    300
 cttctttacc taactaattt ggagaagtct caagataaaa catcgggagg tgttaatcca    360
 gaaccttgtc caatctgtgc tcgacagcta ggaaaacagt gggcggtact gacctgtggt    420
 cactgtttct gtaatgaatg catttctata attattgaac aatacagcgt gggatctcac    480
 agaagctcca ttaagtgtgc aatctgccgc cagaccacat ctcacaaaga aatctcgtat    540
 gtctttacct cagagaaagc aaaccaggag gaggacatcc ctgtgaaggg cagccattct    600
 acaaaagtgg aagctgtggt cagaactctg atgaaaatac agcttagaga tccaggggcc    660
 aaagcactcg ttttctcaac gtggcaagat gtattagata ttatttcaaa agctcttact    720



      <210> 1382
      <211> 4176
      <212> DNA
      <213> Homo sapiens


      <400> 1382
 aaggtaagta taattttctg cttttattga aaatttatat atgactcagt attgtaataa     60
 ataaacataa ccattttcac aaaaaatgac agtgctatgc taaagaagaa aatattaaat    120
 gggggattta cttgtagtgg caagacagac tttttatcaa tacagaataa atattaacag    180
 catttcgtga gccaatggtt gagacccaac aaaatgtagg gaatcaagca tgatgtaaga    240
 aataattttc cagagaaaaa aggatggtgt attctcggat gataagactg tctttgtaaa    300
 ctggggcata tcaattagtc ccatcctcac agctcacctt caaaccacag ggcttgtttc    360
 tggctatgtt aaaaggaccc tcctctgagg aaaagcagag gagaggaact cccattatcc    420
 ttacagtgaa acgcaaccac tgcagaaaaa ctcccactgg gtaaatagaa cacagtttaa    480
 taagtagatt ggatatgatc taactataaa atttaggtaa cagagtaagt gttacatgtg    540
 gcaggaccgg aaaaaaatca tgacattttt cttatcccct tgtacccctc ccactgtcat    600
 tatgctatta ccaacaacaa caagaataat gtttcaaatt ttcctctcat caaaaaatga    660
 gagaaaataa cgagggaagt gtttttgttc tttttcgaac agtttcttga acacctccaa    720
 taccaatcac tcacaaggtg tctgtgcaaa tctatttcac aggatttcaa ggaaattgtt    780
 aactcacaaa aaaatcctta aatgaagcta ttttggagtt ctgtatatta tttggaaagg    840
 agggaggaaa agggtggtgg tggtaaagta gaggtaaagt agtacaatcc agccaaacaa    900
 aatgttaaaa gttttaaatc aacaatgagt ctgacttttt ctggtttggg aagcaagact    960
 ctaaaatgtt gggagagatt ctttctgatc tgatggctac tgaagaacac atttctcctc   1020
 tttcttggcc atcttgcctt tgttttgctc cagagttcgc tccaaatgct catcttcttc   1080
 ttcggcctgc ttctcctgcg cgtccaggtc cctgacgagc gcatcgcgct tgttcaccag   1140
 ggccaccagc tcatctagca gaagctgttc gcgtcgcttc tgggcctcgg tcttctgcca   1200
 gtcttcaatg gctagcattg ccctcaattc ccggttcagc agctcatacc gtcgttctaa   1260
 atcatgttct ttttccagaa gagagagctg attcattctc cttattaagg catttttctt   1320
 attaactaac ataaaccatt cctgcatcat agcttcttct tcttctgtgt tccttcctgt   1380
 gtccatgaga tagcgaaggc gcttctccac cagcgcggca cgggtgtcaa tttgcttttg   1440
 ctcattctct agtgctgcca attctcctac tacatactga ctgggagtct ttgaaccctt   1500
 tattaagcac ttcatcttct gatggcttcc tctgagtttc agttatcgct gccttctcct   1560
 catttccttt ctttgtatct tcctgtattg atctctgcct tttcatctct ggtctattct   1620
 caatatattg gctgaaagac tgaagttgag tttttctgac tgtagaatct ttgctgaaca   1680
 caacaggatt tctaaaacgt tctgttgttt tttgtaatcg ttcagtccgg agatcttctg   1740
 tgccactttt catgtcctgc tctgagctct cagttacagc tttctgggca gcactggagg   1800
 gtgaatttgc cacctgtggc tgaacttcta ggagcttctt cagcttcaag tccaccaact   1860
 tactgttttg ttcgggagta tcaaggtcat tttctaagtt agtaagttca tctccacctc   1920
 ctacaacaaa gccttcaggg atctcctcgt tagtatctat ctcaatatta tcattttcat   1980
 ctccagatgc ctttgacctt tctttcaact tttctgcagc cctttcacca tagctgggaa   2040
 gttctgacat cttccctcca gatcgagctt ctgctattag ctgacgagct ctctctctca   2100
 gctgccgacg tcgctcttca tcttgctgat cacttagctg cctgttgcag aatggggcgg   2160
 ctgtgttggt attgtgctta ttccccgcct ttaaggctgc atctcttctt gcttgctcaa   2220
 gcagaactct tgctctttcc ttaagttctt cttgtctaga taacaatcga tgctggacta   2280
 tttttgatga atgatctgca tgatttaaag tggttctatc agcatctgga tcagactccg   2340
 tctgcctcag ggaagcatgt tttttcttag caaggtctag atctctacta tatgagtatc   2400
 caagtttaga agtaggagat aaacttgttt ttttgatagg agattctgga tctgatctgc   2460
 attctaagga tctggaattc tctaattttt ctttctccaa gttactaccg atgtctagag   2520
 tttgaagctt ttgttcatct gtctcctcac aaataaaggg tggagacata tccttcttct   2580
 tatcactaac atataagtca ctcaattcta aagtctcagc tttcaatagt ctctttttgc   2640
 ctaacaaaac ctgtgcttgg gttgaatctg tattggaaca tattccaggg tcatcagatc   2700
 ctgaagtcct tccagagctc tgctgagact tctggggttc tgtgtcactt ttagtcctgc   2760
 gacagtaagg ggaggctgtg cttggactaa ggtgatcatc aggagtttga tgctcacttt   2820
 ctgactctcc aaccccgcta tcatttacaa atacagagtc atcctgtgat aagaagtcta   2880
 ctgctccgct gataggctgt tgtagttcag gctcccgctt cagatcacta agctctgcat   2940
 agaatttttc ttgatcaaca gaactgtttg tatctgtttc atagtttcca actttatatg   3000
 tgcttttact gctgttttcc tctatctgaa cgacatttag ttcttggcca ctgaaatgtg   3060
 cccttatttg atagagataa gtcataacag tcagtttatc aggaattgct aataatacca   3120
 tatcagaagg ttccaataat cgggaaattc ctatgctggc aaatccatcg tatgcctttt   3180
 tgttgttctc tttaatatct tgaggattca gagacttgta gtcaattaaa tctggtctaa   3240
 agtggtgtaa tattgcacaa aaagataaac catttctcca cgatgtagta aaattggtga   3300
 tttttactcc tcggtagttc tttgtaactt ctttacacca tacaagcaaa gactgactag   3360
 catttggctt tcgccccaaa acaggacttg gtatagggct tggcttagga gaagtagaga   3420
 gatcttttcc tgcagaaact gtgttttcat ttaatactcc tgtttttggt gagaggactg   3480
 gtggagccgg ggcctttctt ttcactcgcc tttcagtttc tagttcttga acaggattta   3540
 ccaaattatt tggaggagga gttgatttag gttcataaaa aggatttgat tcatccaatt   3600
 cttcttcttc agttttagaa ctatcagcat agaggtactt gctcatatcc acaggtctta   3660
 tatttttttt ttttgtagac tggggaggag aatcctttat ggtcacaaat gcttctggct   3720
 catcgaatgg gttcaaatac tgtggagtct gcacctcttt aaagggatta tagctgttat   3780
 tataaaaaga gtcttctgtt tttctaggtg aagctgtttc agtgataggt tcttctgagt   3840
 caggatctcc aaatggattt aattctgcag catcaggatc atcaaatgga tttgaattca   3900
 cggtggccaa gtccttttct gcttcatcca aaaagttaag tttgttgata agctctgtaa   3960
 ttttagctgc cttttcttct tggttcactc tgttctcatc atcatcttca ttatcttctt   4020
 cgaagtcatc taaattggcc aatgtcagcc tggcttcata ctcatccaac taggccaacc   4080
 tttgcatgtc ttcatctgtg gcttttcctt ccctgtgaaa aatgcaagat aatgaaaact   4140
 gaagagcggc agatacaact tttttagata atggct                             4176



      <210> 1383
      <211> 4176
      <212> DNA
      <213> Homo sapiens


      <400> 1383
 aaggtaagta taattttctg cttttattga aaatttatat atgactcagt attgtaataa     60
 ataaacataa ccattttcac aaaaaatgac agtgctatgc taaagaagaa aatattaaat    120
 gggggattta cttgtagtgg caagacagac tttttatcaa tacagaataa atattaacag    180
 catttcgtga gccaatggtt gagacccaac aaaatgtagg gaatcaagca tgatgtaaga    240
 aataattttc cagagaaaaa aggatggtgt attctcggat gataagactg tctttgtaaa    300
 ctggggcata tcaattagtc ccatcctcac agctcacctt caaaccacag ggcttgtttc    360
 tggctatgtt aaaaggaccc tcctctgagg aaaagcagag gagaggaact cccattatcc    420
 ttacagtgaa acgcaaccac tgcagaaaaa ctcccactgg gtaaatagaa cacagtttaa    480
 taagtagatt ggatatgatc taactataaa atttaggtaa cagagtaagt gttacatgtg    540
 gcaggaccgg aaaaaaatca tgacattttt cttatcccct tgtacccctc ccactgtcat    600
 tatgctatta ccaacaacaa caagaataat gtttcaaatt ttcctctcat caaaaaatga    660
 gagaaaataa cgagggaagt gtttttgttc tttttcgaac agtttcttga acacctccaa    720
 taccaatcac tcacaaggtg tctgtgcaaa tctatttcac aggatttcaa ggaaattgtt    780
 aactcacaaa aaaatcctta aatgaagcta ttttggagtt ctgtatatta tttggaaagg    840
 agggaggaaa agggtggtgg tggtaaagta gaggtaaagt agtacaatcc agccaaacaa    900
 aatgttaaaa gttttaaatc aacaatgagt ctgacttttt ctggtttggg aagcaagact    960
 ctaaaatgtt gggagagatt ctttctgatc tgatggctac tgaagaacac atttctcctc   1020
 tttcttggcc atcttgcctt tgttttgctc cagagttcgc tccaaatgct catcttcttc   1080
 ttcggcctgc ttctcctgcg cgtccaggtc cctgacgagc gcatcgcgct tgttcaccag   1140
 ggccaccagc tcatctagca gaagctgttc gcgtcgcttc tgggcctcgg tcttctgcca   1200
 gtcttcaatg gctagcattg ccctcaattc ccggttcagc agctcatacc gtcgttctaa   1260
 atcatgttct ttttccagaa gagagagctg attcattctc cttattaagg catttttctt   1320
 attaactaac ataaaccatt cctgcatcat agcttcttct tcttctgtgt tccttcctgt   1380
 gtccatgaga tagcgaaggc gcttctccac cagcgcggca cgggtgtcaa tttgcttttg   1440
 ctcattctct agtgctgcca attctcctac tacatactga ctgggagtct ttgaaccctt   1500
 tattaagcac ttcatcttct gatggcttcc tctgagtttc agttatcgct gccttctcct   1560
 catttccttt ctttgtatct tcctgtattg atctctgcct tttcatctct ggtctattct   1620
 caatatattg gctgaaagac tgaagttgag tttttctgac tgtagaatct ttgctgaaca   1680
 caacaggatt tctaaaacgt tctgttgttt tttgtaatcg ttcagtccgg agatcttctg   1740
 tgccactttt catgtcctgc tctgagctct cagttacagc tttctgggca gcactggagg   1800
 gtgaatttgc cacctgtggc tgaacttcta ggagcttctt cagcttcaag tccaccaact   1860
 tactgttttg ttcgggagta tcaaggtcat tttctaagtt agtaagttca tctccacctc   1920
 ctacaacaaa gccttcaggg atctcctcgt tagtatctat ctcaatatta tcattttcat   1980
 ctccagatgc ctttgacctt tctttcaact tttctgcagc cctttcacca tagctgggaa   2040
 gttctgacat cttccctcca gatcgagctt ctgctattag ctgacgagct ctctctctca   2100
 gctgccgacg tcgctcttca tcttgctgat cacttagctg cctgttgcag aatggggcgg   2160
 ctgtgttggt attgtgctta ttccccgcct ttaaggctgc atctcttctt gcttgctcaa   2220
 gcagaactct tgctctttcc ttaagttctt cttgtctaga taacaatcga tgctggacta   2280
 tttttgatga atgatctgca tgatttaaag tggttctatc agcatctgga tcagactccg   2340
 tctgcctcag ggaagcatgt tttttcttag caaggtctag atctctacta tatgagtatc   2400
 caagtttaga agtaggagat aaacttgttt ttttgatagg agattctgga tctgatctgc   2460
 attctaagga tctggaattc tctaattttt ctttctccaa gttactaccg atgtctagag   2520
 tttgaagctt ttgttcatct gtctcctcac aaataaaggg tggagacata tccttcttct   2580
 tatcactaac atataagtca ctcaattcta aagtctcagc tttcaatagt ctctttttgc   2640
 ctaacaaaac ctgtgcttgg gttgaatctg tattggaaca tattccaggg tcatcagatc   2700
 ctgaagtcct tccagagctc tgctgagact tctggggttc tgtgtcactt ttagtcctgc   2760
 gacagtaagg ggaggctgtg cttggactaa ggtgatcatc aggagtttga tgctcacttt   2820
 ctgactctcc aaccccgcta tcatttacaa atacagagtc atcctgtgat aagaagtcta   2880
 ctgctccgct gataggctgt tgtagttcag gctcccgctt cagatcacta agctctgcat   2940
 agaatttttc ttgatcaaca gaactgtttg tatctgtttc atagtttcca actttatatg   3000
 tgcttttact gctgttttcc tctatctgaa cgacatttag ttcttggcca ctgaaatgtg   3060
 cccttatttg atagagataa gtcataacag tcagtttatc aggaattgct aataatacca   3120
 tatcagaagg ttccaataat cgggaaattc ctatgctggc aaatccatcg tatgcctttt   3180
 tgttgttctc tttaatatct tgaggattca gagacttgta gtcaattaaa tctggtctaa   3240
 agtggtgtaa tattgcacaa aaagataaac catttctcca cgatgtagta aaattggtga   3300
 tttttactcc tcggtagttc tttgtaactt ctttacacca tacaagcaaa gactgactag   3360
 catttggctt tcgccccaaa acaggacttg gtatagggct tggcttagga gaagtagaga   3420
 gatcttttcc tgcagaaact gtgttttcat ttaatactcc tgtttttggt gagaggactg   3480
 gtggagccgg ggcctttctt ttcactcgcc tttcagtttc tagttcttga acaggattta   3540
 ccaaattatt tggaggagga gttgatttag gttcataaaa aggatttgat tcatccaatt   3600
 cttcttcttc agttttagaa ctatcagcat agaggtactt gctcatatcc acaggtctta   3660
 tatttttttt ttttgtagac tggggaggag aatcctttat ggtcacaaat gcttctggct   3720
 catcgaatgg gttcaaatac tgtggagtct gcacctcttt aaagggatta tagctgttat   3780
 tataaaaaga gtcttctgtt tttctaggtg aagctgtttc agtgataggt tcttctgagt   3840
 caggatctcc aaatggattt aattctgcag catcaggatc atcaaatgga tttgaattca   3900
 cggtggccaa gtccttttct gcttcatcca aaaagttaag tttgttgata agctctgtaa   3960
 ttttagctgc cttttcttct tggttcactc tgttctcatc atcatcttca ttatcttctt   4020
 cgaagtcatc taaattggcc aatgtcagcc tggcttcata ctcatccaac taggccaacc   4080
 tttgcatgtc ttcatctgtg gcttttcctt ccctgtgaaa aatgcaagat aatgaaaact   4140
 gaagagcggc agatacaact tttttagata atggct                             4176



      <210> 1384
      <211> 1120
      <212> DNA
      <213> Homo sapiens


      <400> 1384
 tttttttttt ttgtagagat ggggctttgt catgtgaccc agcctggtct ggaactcctg     60
 ggctcacgcg attctcccac ctttgcctcc caaattgctg ggggattaca ggcgtgagtc    120
 accatgccca gcctaggatg agtttagtaa gatttggtta tgctggggag atgggaaaag    180
 ccagggttag gggcacgcag gctggaagga aacggggtct gtgggggtgg atggaataac    240
 ccatggaggc aagaaaggag cctctgcagg aacaagtctg gaagagcgag gaggaagcgg    300
 tgaggcaggg gagcactgtg tgaactgccc tgaggccagg caggggctca ggatgaccag    360
 gcagaaacag agcgggtcca gggtggaggg gaggcccgtg cagcatgagc aggaggctag    420
 aggagacaga ccatgaggcc cagggagacc cctcactgga gactctcccg tagccttctt    480
 ttcagaagtc gaaagttggt ttttaatccc ttccaaggct tgaatggctc attatcattg    540
 tacacaaagt tttcccaaca atatttaaaa tcttcatagt ccatgatctc cacagcgacc    600
 ccttcctgac tcaggctgcg gagcccctcc tggtaacatg gatactggaa gtagtagagg    660
 cgggcggtga agatggtgag attcacgttg ctgtgcctgg ccaggaactc ggccacctcc    720
 cctgcacagt ctgggcaagg gctccaagat gtgtaccagg tgacctggta ctttgtgtta    780
 ggagacagta tgtcgtcgca gaaccaagag aggaagcacc tttctgcatg acaatgggtc    840
 tcagaatcca cctggtttcg gaagacgccc gtcttccagg agacaactga gcggcgcttt    900
 ataccttcca cggtgaagca cagccaagtt tcgttccgat cgttggcttc ccataggttt    960
 ttaaattgga agtagaatgt gcctggatac attgccttca tcgggtttct gatctgtgga   1020
 ttcatgttca gcctcttaga tatgcttgtc cctgtcccac tcttttctga agcgctgtgg   1080
 cttctcttcc tgcttacagc gtccttggtc gacgcggccg                         1120



      <210> 1385
      <211> 767
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(767)
      <223> n = a,t,c or g


      <400> 1385
 gggccagccc ctgataccct agcttgagag cctatccagg atttgcagta atttgtccat     60
 tttccatgaa aattttaaaa ataaaaaggg caaaatgcag caaaacatcc tcgtagctgc    120
 ccagactttg ctagacaaag ccagtgagtg gttttggtca gcaggcgggc ccaggccgca    180
 gttgagcacc tgtcagccgg tgtcgggcag gtcaggtttg gagggaaggc ctgcgcggct    240
 gtccacaggt ggtttggtca agggcagcct cagaaggtgg cacaggaaag ggtgtgcggg    300
 gtgcaggcct gaccagcgat gtttgcagat ggactgcctc tgggggtcaa cttggggaag    360
 aacaagacct cagtggacgc cgcggaggac tacgcagaag gggtgcgcgt actgggcccc    420
 ctggccgact acctggtggt gaatgtgtcc agccccaaca ctgccgggct gcggagcctt    480
 cagggaaagg ccgagctgcg ccgcctgctg accaaggtgg gcagctgcac ccctctccag    540
 gccctgtccc accagcctgt cccacctgct ccccttcatt ctccagggcg aaccttcagc    600
 atcaccctca gaagctgtcc ttagcaccta gaccagtagg acccctggct ataccttccc    660
 agagtcccct ctgatcccct ctcatgacac tgattatatg cgacggtgac aaattatctg    720
 tccctgctgc tataaatcac ggngtctgta agagcagaca ccacgtc                  767



      <210> 1386
      <211> 516
      <212> DNA
      <213> Homo sapiens


      <400> 1386
 atggctgtca tccagtccct ctcgccatgc tatgagactg tcttgctctc tgagtcctcc     60
 tggtccatgg gctcgcccac ccactgcagg ccatagtcac tgaggaaccg ctccatctcc    120
 ctgacctgcc gctgcagctg cacacacatc gtctccagtt cctcctgccg ctgcagggtt    180
 gcctcggctg ggtgtggccg gagggtctgc accaggtcct ctagggccgc tatcttctga    240
 tccttggaca gtatctcatc agtctgggcc ttcacctgct gctccaggtc ccacaacttc    300
 ctcgtcatga aggccatcag ctccgagtca tgggatgcag ggacatctcc atagatgcgg    360
 attcctcgcc tccttttgcc tcttccactg tctccacaga ggtttctgga agtttctgtt    420
 atctgcctgc tcctctgggt atacggcttt ctgctctgaa ctgagagacc tttggcctgg    480
 tggtgcttgg gaaagtacac gcagggccgc acgaaa                              516



      <210> 1387
      <211> 1852
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1852)
      <223> n = a,t,c or g


      <400> 1387
 agatgggcca tgcgggatcc ctgccacacg ggtgtggggg cagcgcgctc ctccctgcct     60
 cggctgctgt gtgtcttagt cttcatgttt ccccttggcg tctcctctgg tccctgtcca    120
 tcttgtgcac catgtgtccc tgagggcgag tcacacctgt gtcttgagtc tgctgtaagg    180
 tgttcagtct acctcaaggg gtcatcatgg taagctctat cccacggcat cctccgtcca    240
 tcaccacaca cactggaatg tatccccccc gccctgcccc ttcgataacc tcctgacctt    300
 gtctttccta taatcaccac aaactcctag tgcaaattgg atgctgcttt aaatgtgaaa    360
 acaattgttc aaaagctata aaacctgaat cgaaagctga agctgaattt ataagccttg    420
 ttgcatatga gccaaaagtg caaaaagctc tatataatga actaacctgc cactcgtata    480
 aatataaata tatataaata tattaaattc cagactgttc tacaaaattg tgtatttgta    540
 tttttgtgta cgtacaattt tctgctaagc agaagggagg gtgtagtata ggatgctgtg    600
 aggaagagat ttgggtttaa tcctatttct ttggttaact tattttttgt taacatcagg    660
 atgcctgtct ttgtcttatt atgtgtatgg acactgtttg gggaaaggct ggcagtatct    720
 ctcttcctga ggtcccagag ggccattaaa aggaattaaa cagggggctt aggagggtgt    780
 tcttgggccc accaaacaca gggtaaggcc caacagagtt cgggctcccg tacgtgggtg    840
 tggtgggacc tggggcctgg agccacttgt actcctgggg tgggactgag ggagggaaag    900
 ggctccccca cttcaggctg gtcactgtat gttgacttcc ctctgggaag caaaattcca    960
 cttgtaaaaa tcagcttcca agacaaaaga tgatccgatt gtcacttctg ggtcaccagg   1020
 aagggacaca ggatctctct gaactttggg aacagaccct catattctgg gggccagaat   1080
 tttgcccaga aagcagcagg tggctctgcc tggctgtaga gcccagctca ttggctgtcc   1140
 ctgggcttcg tctccctctt ccgagtagtt gctgcctttc ttcagatcag gttaccacaa   1200
 tgcctccccg ctgctgacgc ttcatccccc acacctccag cccccagtta cctgggagct   1260
 tctcagaacc ccactttngc ccggtgctta aaaccaccaa gagggggtga aaagtgggct   1320
 gccagtaatg gcccagaaac caacccaccc ggaggccatg gctgaaagac aagcttccgg   1380
 gtgttccagg ggggttgacg gggcccaacc catgtgggca gggtccccca ggccccccac   1440
 ccccactgcg cccatccgcc ctctggagct cccacagtgg tcccccacct aatggggaac   1500
 ccctccctcn taggggagag tgatacctgc acccttcacc ccgtaggacc tcatatttat   1560
 aacaatgtgt taatggctgt agcaaaaagc cccttgtttc ctagatgtaa atggtcaaag   1620
 aaacaagcgc tctattgttt tgaataaaat agttcaaatg agtccctgta tcgattgtat   1680
 ctcctattct ggattagtgc cttttggaca gtagactgtt ctgtaattaa aaatgtagta   1740
 tactgctttt ttgtacagtt ttgttttaat aaaacttttt tttaatttgt gttctctttt   1800
 agtattgtac ctattagaga atattattgt ataactgaaa aaaaaaaaaa aa           1852



      <210> 1388
      <211> 692
      <212> DNA
      <213> Homo sapiens


      <400> 1388
 acttcctgaa ggcagcggcc ccagctcggg tcccactcat cccatggccc atcacctgcc     60
 tgcagccatg gagagccatc aggacttccg gagcatcaaa gcaaagttcc aggcctctca    120
 gccggagccc agcgacctgc ccaaaaaacc tccgaagcct gagtttggta aactgaagaa    180
 gttctcccag cctgagctaa gcgagcaccc ccagaaggcc ccgctgcctg agtttggtgc    240
 agtgtccttg aagcccccgc agcctcagtt cactgacctc cccaagaagc ccccgccgcc    300
 tgaggtcact gacctcccca agaagccccc gccgcctgag gtcactgacc tccccaagaa    360
 gcccccgccg cctgaggtca ctgacctccc caagaagccc ccgccgcctg aggtcactga    420
 cctccccaag aagccgtcca aactggagtt gagtgacctc tccaagaagt tcccacagct    480
 gggggccact ccgtttccaa ggaagcccct gcagcctgag gtcggtgagg cccctttgaa    540
 ggcctcgctg ccggagcctg gtgcgccggc ccggaaaccc ctgcagcccg acgaactcag    600
 tcaccccgcc agacccccct ccgaacccaa atccggcgca ttccccagga agctctggca    660
 acccgaggcc ggtgaggcta ccccgaggtc cc                                  692



      <210> 1389
      <211> 716
      <212> DNA
      <213> Homo sapiens


      <400> 1389
 tttttttttt ttcacagcag caccagaaac atatacactt tattgaatgc cattgtagaa     60
 aagcgtgtga ggataaaggg ctgatgcagg actcggctgt ggggacaggg cgaggaatgg    120
 aaggtggagt aagtggaata caggtcaagg gcagagctcc tggcctctgg gggcagggcg    180
 aggaatggaa gatagagtac gtgggataca ggtcacgggc agagctcctg gcctcaatga    240
 tgcctcctga tctatcgctg ggcctggacg accaacactg ggatgatgat gagcagaatg    300
 gtcatgaaga tgcccaaaat cagggcccag atgttcaggc acttggcggt ggaggcatag    360
 gcctgggccc cggtcacgtc gccaaccatc ttcctgtccc tagacttcac ggagtacgcg    420
 aatgctatga agcccaggca gcaggtgttc atgaagaggg tgttgaacag ggaccagacg    480
 acatggtcag gcacggaggt ctcgctgcgg atgtggatca cggtggacat cgggggagca    540
 gggttgtggg gcgcccccag catagccact tcctgctcct ccttgagcat ctcgtagttg    600
 ggaggctggc cggctgttga caggagagaa ggtttgcaac aatgtgggtc atggtgacca    660
 agcggtgatc gggggtaacc gggatgggtt ctcaatggag ccccttccct tttccc        716



      <210> 1390
      <211> 545
      <212> DNA
      <213> Homo sapiens


      <400> 1390
 ccgggtcgag ccacgcgtcc ggctggaggc agttgcttcc ctgtagaggg tccggctgcg     60
 gccagtattt tgtgtcatga cttctcaaga gaagacagaa gagtatcctt ttgcagatat    120
 atttgatgaa gatgaaactg aaaggaattt tttgttgtcc aaacctgttt gctttgttgt    180
 atttgggaaa ccaggtgttg ggaaaacaac attagcccgt tacataacac aggcatggaa    240
 atgtattcgt gttgaagctt tgccaatttt agaagaacag attgctgctg aaaccgaatc    300
 aggagttatg ttgcaatcaa tgttgatcag cggtcaaagc attccagatg aacttgtcat    360
 aaagctaatg ttggagaagc tcaactcccc agaagtctgt cactttggtt atattatcac    420
 tgaaatacca tcactttcac aggatgccat gactacctta cagcaaatag aattaattaa    480
 aaacttaaaa cctgaaacct gatgttataa tcaatataaa aggtgtcctt gacttttaat    540
 tgaat                                                                545



      <210> 1391
      <211> 7172
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(7172)
      <223> n = a,t,c or g


      <400> 1391
 cgctcttcca gatggcggcg cgtccgtcgc gagcgaccgg gccgagggga ggccagcgaa     60
 gccgagtaaa accgccgccc gggagaagac tgaaggagca gttgccgccg ttggcggcgg    120
 cccgagcagt tttcgctgct gctacggctg ttgccatgag gcgaggctag ggaggacctc    180
 acttccccgg ggtgtaataa tgttaactga ggccagtcta tccatatggg gatggggaag    240
 ccttggcatt gtcctttttc tgataacctt tggacccttt gtaatatttt atttgacatt    300
 ttatatcctc tgctttgtgg gtgggggttt agtggttact ctcctgtttg gaaaaacaaa    360
 ctcagagaag tacctagaac agtgtgaaca ctcatttctt cctccaacat cacctggggt    420
 tcctaagtgc ttagaagaaa tgaaacggga agccaggact attaagattg atagaagatt    480
 gacgggtgcc aatataattg atgaacctct ccagcaagtt atccagtttt ccttgaggga    540
 ttatgtccag tattggtatt atacactaag cgatgatgaa tcttttcttc ttgaaattag    600
 gcagactctt caaaacgcac tcattcagtt tgctactagg tcaaaagaaa tagactggca    660
 accttatttt actacacgca ttgtagatga ctttggcaca cacttacgag tattcagaaa    720
 ggctcaacag aaaataacag agaaagatga tcaagtgaaa ggtacagcag aagatcttgt    780
 agataccttc tttgaagttg aagttgaaat ggagaaggag gtttgccgtg atctagtgtg    840
 cacttccccc aaagatgaag aaggattcct aagggatttg tgtgaggtct tactatattt    900
 attgctacct cctggagatt tccagaacaa gatcatgcga tactttgtca gggaaatcct    960
 tgcacgagga attcttcttc cattaataaa tcaactcagt gatcctgatt atattaatca   1020
 gtatgtcata tggatgatcc gtgattctaa ctgcaactat gaggccttta tgaacattat   1080
 taaattgagt gacaatattg gagagctaga agcagtcaga gataaggcag cagaagaatt   1140
 acagtatctt agatctctag atacagctgg tgatgatatc aacactatca aaaatcaaat   1200
 aaatagctta ctattcgtaa agaaggtatg tgactcaaga atacagcgat tgcagtcagg   1260
 caaagaaata aatactgtga aacttgcagc aaactttggg aaactttgca cagtccccct   1320
 ggacagcatt cttgtagaca atgttgcact acaatttttt atggattaca tgcagcaaac   1380
 tggaggtcaa gcacatctat tcttttggat gacagtggaa ggataccggg ttaccgccca   1440
 acagcagcta gaagttttat taagtcgtca gagagatgga aaacatcaaa ccaaccaaac   1500
 caaaggtctt ttaagagcag ctgctgttgg aatttatgaa cagtatttat cagaaaaggc   1560
 atctccaaga gttactgttg atgactattt agtagcaaaa ttagcagata ctttgaatca   1620
 tgaagatcca acccctgaaa tctttgatga cattcaaaga aaggtatatg aattgatgct   1680
 acgagatgaa agattttatc cttccttcag acagaatgca ctttatgtgc gcatgttagc   1740
 tgagcttgac atgttaaaag atcctagttt cagaggatcc gatgatgggg atggagaatc   1800
 ttttaatggg tctcctacag gaagcataaa tttgtcttta gatgaccttt caaatgtttc   1860
 ttctgatgac tcagtacaac ttcatgccta catttcagac acagtatatg ctgactatga   1920
 cccatatgct gtggcaggcg tttgtaatga tcatggcaag acatatgcat tatatgccat   1980
 cactgtacac cggcgcaacc taaacagtga ggagatgtgg aaaacctatc gtcgttatag   2040
 tgacttccat gacttccaca tgagaatcac tgaacagttt gaaagtctct caagcatatt   2100
 gaaacttcct gaaaaaaaga cttttaataa tatggataga gattttttag aaaagagaaa   2160
 aaaggatcta aatgcatatt tgcagttact gttagctcct gaaatgatga aggcatcccc   2220
 agctttagct cactatgtgt atgatttcct tgagaacaaa gcctacagta aaggaaaagg   2280
 ggattttgct cgcaagatgg acacttttgt aaatccactt cgcaattcaa tgaggaatgt   2340
 ttcaaatgca gttaaatccc ttcctgatag cttggcagag ggaatgacta aaatgtcaga   2400
 caacatgggc aaaatgtcag aaagattagg tcaagacata aagcaatcat tttttaaggt   2460
 gcctccttta attcctaaga ctgattcaga ccctgaacat cgccgagttt cggctcaact   2520
 tgacgataat gtggatgaca atattccact tagggtaatg ctgcttctca tggatgaagt   2580
 attcgactta aaagaaagaa atcagtggtt gcgaaggaat atcaaaaacc tacttcaaca   2640
 gcttattaga gctacatatg gcgatactat taatagaaaa atagttgacc atgttgactg   2700
 gatgacttca cctgaacaag tagccgactc agtgaaacgt ttcagagatg cattttggcc   2760
 aaatggcatt ttagcagagg ctgttccatg cagagataaa agtattcgaa tgagaacaag   2820
 agtagcagga aaaacgaaat tacttgcaat tatgccaggt gagtgagcat gtatagttaa   2880
 aaatctttat aatttgtcat tcttctgagt ttttagcatt catcatgcca gtgtaactgc   2940
 cttttgatta taacaactac cttttgatgg cttaatacat atcaggcact gtactaggca   3000
 tttctcatat gttcttaatc agtcctcatg acagtactgt aaagctaagg actgttaaca   3060
 tcaccgcttt atatgtgagg aaacggaagc tcagagaggt taaataacct atccaaggtt   3120
 tatagctact aagcaacagt tggtattctg acttggcttt aagtgatgtg aaagcttatg   3180
 cttttagcca cttcgctctg ctgccttgaa acatattggg agttaagtta aataaataaa   3240
 atacatgaca ggtgaaaggg ctaataaaat ataaagtatg aatttttcag gaagaatatt   3300
 tgttgtactt aggaaaacaa gttatttcaa aaactccatt tacatagaaa gaactgattg   3360
 gctgattatt aatctttatt acttaaaata caatcccaaa caaagtatac ttagtagcat   3420
 tttgttggtc tgattttggt tgcttcatta gggtatagct atctcactac cttagattta   3480
 ctttttctcg tttttcttct ttcaatcaga gaagttatat aatgtaaaaa gcaatttaat   3540
 gcggctggga ggtggtgatg gttgttttgc cccttgttaa tgagtatctt tgaaaatgcc   3600
 tgcatgtctt ttctctgtat tttaattctg gatgtagaga atgaacagac atatttgtac   3660
 attctttaat atcacacaat accaattttt ttctctaatt ttgttttctt acctgtattt   3720
 tctctataaa ttttaatgac cagccttctc ttctgtcaat taaattaaaa atttgccaca   3780
 attttaattc ttacctatat accgtttcat ttgctgataa aaaagcaaat tatagaaatg   3840
 acattttaga aaaataagaa acaattgctt aggatattat ttaatatact attatagtaa   3900
 acctgattgt gctatatgga ctgactcagt tatctagctg gaagaaatct ttattcacta   3960
 aatatttatt gaaagttatt atgtgccagg tgctgttctt tgcacttatg tttgccttct   4020
 tggagcttac tttccagtag aaatagagag actcaaaaac acacagaaca aataaatgga   4080
 acgtagtttg ttagataagt ggtaagtact aaagagaaag atactgcagg aaaatggaat   4140
 agatagtgtc agatgagttg cagttttaga tggggtggcc agggcaggcc tcactgagat   4200
 gatgatggtg gtgtgaagat ctgaaggaag tgagggtaaa tatgaaagca tataaattta   4260
 tatatacata atccttgcct attttttagt aaattctcaa aatttttgct ttaaattata   4320
 tcgtacccct agttagataa agactttttg gaaattgcat gtttctttcc aaagcagcaa   4380
 aataatatct atattatcag tattatgaat aattatttgt aattatgaat aagaatatga   4440
 ataattaata atcatacatg ttggtctcat aacttggtgt tatttatgat taaacaccaa   4500
 atttgctcac tcttagtcac agcaccatcg gttttctatt ttctttgctt tcttcacttt   4560
 gaatttaaat aaaattcaac ccaacttgta ctatccctat ttcttgagca tgctttgttt   4620
 ttctagttac tgcttatttg ctcattcatg ttcttttcac caaggctaat ccttcatctc   4680
 attgcaccta tcaaaatcct gcccaagtag aaagtctcct ttacctgcca cttccttaaa   4740
 gggaactttt ctttgttatc gcatctgaaa gtctccccac taccaatatt cttatacttt   4800
 tagcattttt atggtatagt tactatgcca ggggtttttg tagatcaggg attaattttt   4860
 ttttttcctg tgttccaatg aaactttatt caccatcatg gattagtttg tttccttaca   4920
 gcatttgtca ctattcatta ggcctactaa gaatatttgt ataatattac aaagtttaca   4980
 gatcactttt tacattattt cattaaagac ttataaatcc ttataaggat gttattataa   5040
 atcctccttt tcagatgaga aaagagagtc agggtggtgg gtaagtatca catgggtatt   5100
 aagggacatg tttgtaatca tagtttggga tctttgagac tgttttttat tttttatctc   5160
 ttacacctgt gctatattgt ctcccagtag cttttgcatt aagtgcgtaa atagatgcat   5220
 gcatgcaaag atgcatatta agtttcagct atagtacata gctgaaatgc attaactggt   5280
 tacctactgt tcatcagtta ctctgctgtg taccttaatt taagaacatt taagagttta   5340
 ggccttgtgt ttcctttgaa taattatgtg tgttttcctc cacttcattt agatgagctg   5400
 aagcacatta ttggggctga gacaacacgg aaaggtattc ttcgtgtttt tgaaatgttt   5460
 cagcacaacc aattaaatag gagaatggtt tatgtcttct tggaaggctt tttagaaacc   5520
 ttatttccac agtataaatt ccgtgaactt ttcaacaaac tgcattcacg gtcaaagcag   5580
 atgcagaaat ataaacagaa acttcaaact actcaagcgc cttctttgca gaaaaggtga   5640
 cactccactc tatgaagctg gtgttcattt tgtccaggac taatggtatg gacagatctt   5700
 ctggggctta actcaaatac tgttgtgtct gcaccagtct tttagtgtct caaaatagat   5760
 tattaataca tccataagtc tgtggttctt ctcattctca tctataatcc accactacca   5820
 agagagattt ctgtgtctta aatgatttgg tgcatatttt gcaacattga gagaaaactg   5880
 cccccatctc aagcaagaat gggcgttggt ttcttccatt tcaaactaat cagcattctc   5940
 caggcaatga cacaagtgcc cagagtgtat attatgaaaa gctaaaggaa agcacaaaac   6000
 aatggttcag aagataaatt ggctaatttg tttaacagtt ggagactgtg caatgtacgg   6060
 acttggagga gtttgtttgg cataatgatt ttgtaggtct gtcagcattt tggatatatt   6120
 gtgggattag ccaggtgtat gatcctttga aacatctctt tcaggtctgg agaaagagac   6180
 agaatgccct taaagtgtga aataacctta tacctgaatt acagttttgt gatataaaat   6240
 aaagctgagt ataaaataaa accaatcaaa cacagaattt gattggattt gttattcatt   6300
 ggtatacaac aatttttatt cttatgtgtg ctttaagggc tgtgttttgc tcttagggta   6360
 ctcaatttta tgtttccttt tggcattctt tgtgcaaaaa gaagcatgtg gtggctctca   6420
 tttaaatttc caaattatta gtttttatct taaacagatt actgattata cagaagatat   6480
 aatttattgg aagaactgcc aaatacattt tgtccttcta aaaatatgga aatttaaata   6540
 gtagtctgga aagttaccat atgataattt ttaattgtgt gatctagaca tgccttaggt   6600
 aactgcagaa atagcaaatt aaatgattaa tgagcttatt agtcatagta aacatacaga   6660
 ttcctaattc tatgacagtg tacatatatg aaaataaatg atgaaaaaag aactataata   6720
 tttttaaaaa tatgctttta tttatatttc acataatgta aagttctaca aaataaagct   6780
 agtaggcaag acccctcagt gtataccttt aaacccataa attaatttta tatcaataaa   6840
 ataaaatact ttctctagtt ttggagcttt tgcatttcct atagttttct gactgtccat   6900
 tttatccatc ttagaagtat tcacatccct tctatgcagg atttctgcat agttttaaat   6960
 actttcattg cctaagggtt tgggtgtgtc agcttttttt gttttaaaaa tatttaacac   7020
 taaaacctta aaataatgaa gctacttatc agaccactga ggccaagatc ctggggtatt   7080
 taaaaggaaa gtctggggtg cttaaggatt aaaggggaca ggagtattgg gtatccccag   7140
 tttatttggg ggggctttaa ggntggggaa cc                                 7172



      <210> 1392
      <211> 7172
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(7172)
      <223> n = a,t,c or g


      <400> 1392
 cgctcttcca gatggcggcg cgtccgtcgc gagcgaccgg gccgagggga ggccagcgaa     60
 gccgagtaaa accgccgccc gggagaagac tgaaggagca gttgccgccg ttggcggcgg    120
 cccgagcagt tttcgctgct gctacggctg ttgccatgag gcgaggctag ggaggacctc    180
 acttccccgg ggtgtaataa tgttaactga ggccagtcta tccatatggg gatggggaag    240
 ccttggcatt gtcctttttc tgataacctt tggacccttt gtaatatttt atttgacatt    300
 ttatatcctc tgctttgtgg gtgggggttt agtggttact ctcctgtttg gaaaaacaaa    360
 ctcagagaag tacctagaac agtgtgaaca ctcatttctt cctccaacat cacctggggt    420
 tcctaagtgc ttagaagaaa tgaaacggga agccaggact attaagattg atagaagatt    480
 gacgggtgcc aatataattg atgaacctct ccagcaagtt atccagtttt ccttgaggga    540
 ttatgtccag tattggtatt atacactaag cgatgatgaa tcttttcttc ttgaaattag    600
 gcagactctt caaaacgcac tcattcagtt tgctactagg tcaaaagaaa tagactggca    660
 accttatttt actacacgca ttgtagatga ctttggcaca cacttacgag tattcagaaa    720
 ggctcaacag aaaataacag agaaagatga tcaagtgaaa ggtacagcag aagatcttgt    780
 agataccttc tttgaagttg aagttgaaat ggagaaggag gtttgccgtg atctagtgtg    840
 cacttccccc aaagatgaag aaggattcct aagggatttg tgtgaggtct tactatattt    900
 attgctacct cctggagatt tccagaacaa gatcatgcga tactttgtca gggaaatcct    960
 tgcacgagga attcttcttc cattaataaa tcaactcagt gatcctgatt atattaatca   1020
 gtatgtcata tggatgatcc gtgattctaa ctgcaactat gaggccttta tgaacattat   1080
 taaattgagt gacaatattg gagagctaga agcagtcaga gataaggcag cagaagaatt   1140
 acagtatctt agatctctag atacagctgg tgatgatatc aacactatca aaaatcaaat   1200
 aaatagctta ctattcgtaa agaaggtatg tgactcaaga atacagcgat tgcagtcagg   1260
 caaagaaata aatactgtga aacttgcagc aaactttggg aaactttgca cagtccccct   1320
 ggacagcatt cttgtagaca atgttgcact acaatttttt atggattaca tgcagcaaac   1380
 tggaggtcaa gcacatctat tcttttggat gacagtggaa ggataccggg ttaccgccca   1440
 acagcagcta gaagttttat taagtcgtca gagagatgga aaacatcaaa ccaaccaaac   1500
 caaaggtctt ttaagagcag ctgctgttgg aatttatgaa cagtatttat cagaaaaggc   1560
 atctccaaga gttactgttg atgactattt agtagcaaaa ttagcagata ctttgaatca   1620
 tgaagatcca acccctgaaa tctttgatga cattcaaaga aaggtatatg aattgatgct   1680
 acgagatgaa agattttatc cttccttcag acagaatgca ctttatgtgc gcatgttagc   1740
 tgagcttgac atgttaaaag atcctagttt cagaggatcc gatgatgggg atggagaatc   1800
 ttttaatggg tctcctacag gaagcataaa tttgtcttta gatgaccttt caaatgtttc   1860
 ttctgatgac tcagtacaac ttcatgccta catttcagac acagtatatg ctgactatga   1920
 cccatatgct gtggcaggcg tttgtaatga tcatggcaag acatatgcat tatatgccat   1980
 cactgtacac cggcgcaacc taaacagtga ggagatgtgg aaaacctatc gtcgttatag   2040
 tgacttccat gacttccaca tgagaatcac tgaacagttt gaaagtctct caagcatatt   2100
 gaaacttcct gaaaaaaaga cttttaataa tatggataga gattttttag aaaagagaaa   2160
 aaaggatcta aatgcatatt tgcagttact gttagctcct gaaatgatga aggcatcccc   2220
 agctttagct cactatgtgt atgatttcct tgagaacaaa gcctacagta aaggaaaagg   2280
 ggattttgct cgcaagatgg acacttttgt aaatccactt cgcaattcaa tgaggaatgt   2340
 ttcaaatgca gttaaatccc ttcctgatag cttggcagag ggaatgacta aaatgtcaga   2400
 caacatgggc aaaatgtcag aaagattagg tcaagacata aagcaatcat tttttaaggt   2460
 gcctccttta attcctaaga ctgattcaga ccctgaacat cgccgagttt cggctcaact   2520
 tgacgataat gtggatgaca atattccact tagggtaatg ctgcttctca tggatgaagt   2580
 attcgactta aaagaaagaa atcagtggtt gcgaaggaat atcaaaaacc tacttcaaca   2640
 gcttattaga gctacatatg gcgatactat taatagaaaa atagttgacc atgttgactg   2700
 gatgacttca cctgaacaag tagccgactc agtgaaacgt ttcagagatg cattttggcc   2760
 aaatggcatt ttagcagagg ctgttccatg cagagataaa agtattcgaa tgagaacaag   2820
 agtagcagga aaaacgaaat tacttgcaat tatgccaggt gagtgagcat gtatagttaa   2880
 aaatctttat aatttgtcat tcttctgagt ttttagcatt catcatgcca gtgtaactgc   2940
 cttttgatta taacaactac cttttgatgg cttaatacat atcaggcact gtactaggca   3000
 tttctcatat gttcttaatc agtcctcatg acagtactgt aaagctaagg actgttaaca   3060
 tcaccgcttt atatgtgagg aaacggaagc tcagagaggt taaataacct atccaaggtt   3120
 tatagctact aagcaacagt tggtattctg acttggcttt aagtgatgtg aaagcttatg   3180
 cttttagcca cttcgctctg ctgccttgaa acatattggg agttaagtta aataaataaa   3240
 atacatgaca ggtgaaaggg ctaataaaat ataaagtatg aatttttcag gaagaatatt   3300
 tgttgtactt aggaaaacaa gttatttcaa aaactccatt tacatagaaa gaactgattg   3360
 gctgattatt aatctttatt acttaaaata caatcccaaa caaagtatac ttagtagcat   3420
 tttgttggtc tgattttggt tgcttcatta gggtatagct atctcactac cttagattta   3480
 ctttttctcg tttttcttct ttcaatcaga gaagttatat aatgtaaaaa gcaatttaat   3540
 gcggctggga ggtggtgatg gttgttttgc cccttgttaa tgagtatctt tgaaaatgcc   3600
 tgcatgtctt ttctctgtat tttaattctg gatgtagaga atgaacagac atatttgtac   3660
 attctttaat atcacacaat accaattttt ttctctaatt ttgttttctt acctgtattt   3720
 tctctataaa ttttaatgac cagccttctc ttctgtcaat taaattaaaa atttgccaca   3780
 attttaattc ttacctatat accgtttcat ttgctgataa aaaagcaaat tatagaaatg   3840
 acattttaga aaaataagaa acaattgctt aggatattat ttaatatact attatagtaa   3900
 acctgattgt gctatatgga ctgactcagt tatctagctg gaagaaatct ttattcacta   3960
 aatatttatt gaaagttatt atgtgccagg tgctgttctt tgcacttatg tttgccttct   4020
 tggagcttac tttccagtag aaatagagag actcaaaaac acacagaaca aataaatgga   4080
 acgtagtttg ttagataagt ggtaagtact aaagagaaag atactgcagg aaaatggaat   4140
 agatagtgtc agatgagttg cagttttaga tggggtggcc agggcaggcc tcactgagat   4200
 gatgatggtg gtgtgaagat ctgaaggaag tgagggtaaa tatgaaagca tataaattta   4260
 tatatacata atccttgcct attttttagt aaattctcaa aatttttgct ttaaattata   4320
 tcgtacccct agttagataa agactttttg gaaattgcat gtttctttcc aaagcagcaa   4380
 aataatatct atattatcag tattatgaat aattatttgt aattatgaat aagaatatga   4440
 ataattaata atcatacatg ttggtctcat aacttggtgt tatttatgat taaacaccaa   4500
 atttgctcac tcttagtcac agcaccatcg gttttctatt ttctttgctt tcttcacttt   4560
 gaatttaaat aaaattcaac ccaacttgta ctatccctat ttcttgagca tgctttgttt   4620
 ttctagttac tgcttatttg ctcattcatg ttcttttcac caaggctaat ccttcatctc   4680
 attgcaccta tcaaaatcct gcccaagtag aaagtctcct ttacctgcca cttccttaaa   4740
 gggaactttt ctttgttatc gcatctgaaa gtctccccac taccaatatt cttatacttt   4800
 tagcattttt atggtatagt tactatgcca ggggtttttg tagatcaggg attaattttt   4860
 ttttttcctg tgttccaatg aaactttatt caccatcatg gattagtttg tttccttaca   4920
 gcatttgtca ctattcatta ggcctactaa gaatatttgt ataatattac aaagtttaca   4980
 gatcactttt tacattattt cattaaagac ttataaatcc ttataaggat gttattataa   5040
 atcctccttt tcagatgaga aaagagagtc agggtggtgg gtaagtatca catgggtatt   5100
 aagggacatg tttgtaatca tagtttggga tctttgagac tgttttttat tttttatctc   5160
 ttacacctgt gctatattgt ctcccagtag cttttgcatt aagtgcgtaa atagatgcat   5220
 gcatgcaaag atgcatatta agtttcagct atagtacata gctgaaatgc attaactggt   5280
 tacctactgt tcatcagtta ctctgctgtg taccttaatt taagaacatt taagagttta   5340
 ggccttgtgt ttcctttgaa taattatgtg tgttttcctc cacttcattt agatgagctg   5400
 aagcacatta ttggggctga gacaacacgg aaaggtattc ttcgtgtttt tgaaatgttt   5460
 cagcacaacc aattaaatag gagaatggtt tatgtcttct tggaaggctt tttagaaacc   5520
 ttatttccac agtataaatt ccgtgaactt ttcaacaaac tgcattcacg gtcaaagcag   5580
 atgcagaaat ataaacagaa acttcaaact actcaagcgc cttctttgca gaaaaggtga   5640
 cactccactc tatgaagctg gtgttcattt tgtccaggac taatggtatg gacagatctt   5700
 ctggggctta actcaaatac tgttgtgtct gcaccagtct tttagtgtct caaaatagat   5760
 tattaataca tccataagtc tgtggttctt ctcattctca tctataatcc accactacca   5820
 agagagattt ctgtgtctta aatgatttgg tgcatatttt gcaacattga gagaaaactg   5880
 cccccatctc aagcaagaat gggcgttggt ttcttccatt tcaaactaat cagcattctc   5940
 caggcaatga cacaagtgcc cagagtgtat attatgaaaa gctaaaggaa agcacaaaac   6000
 aatggttcag aagataaatt ggctaatttg tttaacagtt ggagactgtg caatgtacgg   6060
 acttggagga gtttgtttgg cataatgatt ttgtaggtct gtcagcattt tggatatatt   6120
 gtgggattag ccaggtgtat gatcctttga aacatctctt tcaggtctgg agaaagagac   6180
 agaatgccct taaagtgtga aataacctta tacctgaatt acagttttgt gatataaaat   6240
 aaagctgagt ataaaataaa accaatcaaa cacagaattt gattggattt gttattcatt   6300
 ggtatacaac aatttttatt cttatgtgtg ctttaagggc tgtgttttgc tcttagggta   6360
 ctcaatttta tgtttccttt tggcattctt tgtgcaaaaa gaagcatgtg gtggctctca   6420
 tttaaatttc caaattatta gtttttatct taaacagatt actgattata cagaagatat   6480
 aatttattgg aagaactgcc aaatacattt tgtccttcta aaaatatgga aatttaaata   6540
 gtagtctgga aagttaccat atgataattt ttaattgtgt gatctagaca tgccttaggt   6600
 aactgcagaa atagcaaatt aaatgattaa tgagcttatt agtcatagta aacatacaga   6660
 ttcctaattc tatgacagtg tacatatatg aaaataaatg atgaaaaaag aactataata   6720
 tttttaaaaa tatgctttta tttatatttc acataatgta aagttctaca aaataaagct   6780
 agtaggcaag acccctcagt gtataccttt aaacccataa attaatttta tatcaataaa   6840
 ataaaatact ttctctagtt ttggagcttt tgcatttcct atagttttct gactgtccat   6900
 tttatccatc ttagaagtat tcacatccct tctatgcagg atttctgcat agttttaaat   6960
 actttcattg cctaagggtt tgggtgtgtc agcttttttt gttttaaaaa tatttaacac   7020
 taaaacctta aaataatgaa gctacttatc agaccactga ggccaagatc ctggggtatt   7080
 taaaaggaaa gtctggggtg cttaaggatt aaaggggaca ggagtattgg gtatccccag   7140
 tttatttggg ggggctttaa ggntggggaa cc                                 7172



      <210> 1393
      <211> 719
      <212> DNA
      <213> Homo sapiens


      <400> 1393
 atcgagagcc tatcgatgtg gggcttttct tacagattgg gaaatggtgg tggggaaacc     60
 gaacaattta tgtttgctct tgaaactgtt ttaggtgtgg cctgaagtca ctgatcctga    120
 gaagttcgtg tatgaagatg tggctatcgc agcatacctg ctgattctat gggaagaaga    180
 aagggctgag aggggactaa ctgccaggca gtcctttgtg gacctgggat gtggaaatgg    240
 cctcctggtc cacatcctga gcagtgaggg gcatccaggc agagggattg atgtccgaag    300
 aagaaaaatc tgggacatgt atggaccaca aactcagtta gaggaagatg caatcacacc    360
 caatgataag acccttttcc ctgatgttga ttggttaatc ggtaaccatt ctgatgaact    420
 cacaccatgg atacctgtca ttgcagccag gtcttcctac aattgccgct tctttgtcct    480
 cccctgctgc ttctttgact tcattggaag atactcccgg aggcagagta agaagactca    540
 gtaccgggaa taccttgact tcattaaaga agtgggcttc acctgtgggt ttcacgtgga    600
 cgaagactgc ctcaggattc cttcaaccac aagagtctgt ctcgttggaa aatccagaac    660
 atacccttac tccatagaag cttccgtgga tgaaaagagg actcagtaca ttaagagcc     719



      <210> 1394
      <211> 645
      <212> DNA
      <213> Homo sapiens


      <400> 1394
 tttttttttt ttgcactgcc acatagattt taatttgcct aaagatgata gcgattttga     60
 gctgtggtta gggataactg ttcccacagt agacctatta ccaacatgag ttgctggctt    120
 tcatttaata ggactccaag ctggcaaaca aaccccacca tcttcccaac agccacatca    180
 tgagatctag cagcaccagc ctcttgaagt ggcttctcag tggaaggttt gctccgtttc    240
 agtgaagctt ctctctcaaa gctctgacgt caccagggtg cccctcgagg gtctggatag    300
 actgtccgaa aggtcaggtt cactctcggt tctctagagt ggtattcttt gggcactcga    360
 tgctgccagt cagcttgtgt cgctccttcc atgattaaca aggtcccatg atccaagggt    420
 atcttcactc tttccacata tgtgtagtct ccattctctt cctagaaaac agcatttgtt    480
 gtaataaatg ttttgcctgt gtaatcaaga tgcaacagaa cctgacagag gtcaaaaaaa    540
 aatggaaacc tctgctcagc cagactgtgg gaatccatat atagctctgt catttggcag    600
 ctgcttgact gttggcaagt tacctcatct ctctgtaccc tgact                    645



      <210> 1395
      <211> 1463
      <212> DNA
      <213> Homo sapiens


      <400> 1395
 tttttttttt ttcacagcca attttcacac tgttgtttca cattctcaca gccctcagca     60
 caggtcacgt cccagcccag ctctgggact ttggttcagg gctcagagcc tctggtctgg    120
 gctgatcgaa aacctccttt gaccctgtgg cagcaggcgg accttggctc ttctcgtcct    180
 tacccagagc tcagggcagt gccccgtgca gtcgccccac ttccacgaag gcctccacgc    240
 agcggtcaat gtcttcctcg ctatgcactg ctgagatctg tacccggatc cgggccttgc    300
 ccttggggac cacggggtag ctgaacccga tgacaaagat gcctctcttc agcatgtcat    360
 ccgccatgcg agaggccagc cgggcatcac ccagcatcac agggcagatg gggtgactgg    420
 ctcccgagat agtgaagcca gcagcttcca tcttactacg gaacctctgg gtcttggcag    480
 ccatagactg gacaatggtg ttactcccca tcagcagatc tagggccttg gaggcgcagc    540
 caacgacagc aggtggcaga ctgttggaga agaggtatgg ccgggcgcgc tgccgcagca    600
 gggacaccag gggcccaggc cctgtcgtgt agccccctga tgctccaccc agggccttcc    660
 ccagggtgga gttgatgatg gtgacctggt ccatcacacc cagcagctca tctgtgcccc    720
 gtcctgtggg ccccaggaag ccagtggcat ggcattcatc catgaagacc agggcaccat    780
 atctagaggc gaggcagcag atctcctgca ggggtgcgat gtcgccatcc atggaaaagg    840
 ccccatcagt ggccaccagg cgcagccgat gcttctgggc ctcctgcagc ttggcttcta    900
 ggtcggccat gtccaggtgg cgatagcggt acttgtgggc cttgcacagc cggatgccgt    960
 cgatgatgga ggcatggttc agctcgtccg acaggactgc gtcctctggg gtcagcaggg   1020
 cctcaaagag gccggcgttg gcgtcataac agctgggata gaggatggca tcctcccgct   1080
 ggtggaagcg ggctattttt gcttctagat tcttgtggat gctctgggtt ccacagataa   1140
 agcggacaga gctgaggcca gctccaaact cctccagagc ctgcagacct gcctggatca   1200
 cctcagggtg gctgctcagg cccaggtagt tgttggcaca gaagttaagg attcctccgg   1260
 agacgccgtc cacgcggatg tgcggcccct gacgggacgt gatgacccgc tcactcttcc   1320
 aagtgccagc tccgcagatg ccttccagct ccccctccag aatgccacgc agctgggcca   1380
 gcgctgactg tgcgcggcgg ccgcggggca cccagaagag tgcggcgcgc caggcgttcc   1440
 caggccacat cgctcggcac gag                                           1463



      <210> 1396
      <211> 2210
      <212> DNA
      <213> Homo sapiens


      <400> 1396
 cggacgcgtg ggcacttgcc tccctgcctg cttctggctg ccttgaatgc ctggtccttc     60
 aagctccttc tgggtctgac aaagcaggga ccatgtctac ctttggctac cgaagaggac    120
 tcagtaaata cgaatccatc gacgaggatg aactcctcgc ctccctgtca gccgaggagc    180
 tgaaggagct agagagagag ttggaagaca ttgaacctta ccgcaacctt cccgtggggc    240
 taaggcaaaa gagcctgaca gagaaaaccc ccacaggagc attcagcaga gaggcactga    300
 tggcctattg ggaaaaggag tcccaaaaac tcttggagaa ggagaggctg ggggaatgtg    360
 gaaaggttgc agaagacaaa gaggaaagtg aggaagagct tatctttact gaaagtaaca    420
 gtgaggtttc tgaggaagtg tatacagagg aggaggagga ggagtcccag gaggaagagg    480
 aggaagaaga cagtgacgaa gaggaaagaa caattgaaac tgcaaaaggg attaatggaa    540
 ctgtaaatta tgatagtgtc aattctgaca actctaagcc aaagatattt aaaagtcaaa    600
 tagagaacat aaatttgacc aatggcagca atgggaggaa cacagagtcc ccagctgcca    660
 ttcacccttg tggaaatcct acagtgattg aggacgcttt ggacaagatt aaaagcaatg    720
 accctgacac cacagaagtc aatttgaaca acattgagaa catcacaaca cagaccctta    780
 cccgctttgc tgaagccctc aaggacaaca ctgtggtgaa gacgttcagt ctggccaaca    840
 cgcatgccga cgacagtgca gccatggcca ttgcagagat gctcaaagtc aatgagcaca    900
 tcaccaacgt aaacgtcgag tccaacttca taacgggaaa ggggatcctg gccatcatga    960
 gagctctcca gcacaacacg gtgctcacgg agctgcgttt ccataaccag aggcacatca   1020
 tgggcagcca ggtggaaatg gagattgtca agctgctgaa ggagaacacg acgctgctga   1080
 ggctgggata ccattttgaa ctcccaggac caagaatgag catgacgagc attttgacaa   1140
 gaaatatgga taaacagagg caaaaacgtt tgcaggagca aaaacagcag gagggatacg   1200
 atggaggacc caatcttagg accaaagtct ggcaaagagg aacacctagc tcttcacctt   1260
 atgtatctcc caggcactca ccctggtcat ccccaaaact cctcctcccc ctccttcttc   1320
 ccaaaggctg ccaccacctc ctcctcctcc ccctcctcca ctcccagaga aaaagctcat   1380
 taccagaaac attgcagaag tcatcaaaca acaggagagt gcccaacggg cattacaaaa   1440
 tggacaaaaa aagaaaaaag ggaaaaaggt caagaaacag ccaaacagta ttctaaagga   1500
 aataaaaaat tctctgaggt cagtgcaaga gaagaaaatg gaagacagtt cccgaccttc   1560
 taccccacag agatcagctc atgagaatct catggaagca attcggggaa gcagcataaa   1620
 acagctaaag cgggtggaag ttccagaagc cctgcgataa aaacatgatc tttagaagag   1680
 gatgcagaac tgttcagtgg tattacatga aatgcattgt gagatgtttc taaaatacct   1740
 tcttcaattc aaaatgatcc ctgactttaa aaataatctc acccattaat tccaaagaga   1800
 atcttaagaa acaatcagca tgtttcttct gtaaatatga aaataaattt cttttttatg   1860
 tcgtgagatt tgtattggca agaagcagtt aatttaaaga tgctcttcct atctgtggat   1920
 gtgttggtaa ctccgagttg taatgagttc atgaaatgtg ctgttatttt tgtaatctca   1980
 ataaatgtgg attgaagttt tttccctttt tttaaagcca aactaatatt tttctgtgac   2040
 ttgatacatc tgtcagattt ttgtaatctc gataaatgtg tattgaagtt ttttcccttt   2100
 ttttaaaaag ccaaactaat atttttctgt gagttaatac atctgtcagg tgtgtatgta   2160
 acattactgg acattaaaaa aaattattac attctcaccc aaaaaaaaaa              2210



      <210> 1397
      <211> 563
      <212> DNA
      <213> Homo sapiens


      <400> 1397
 attgtgtgac acttgatagt tattagaaag aggcagatca gggcaaaaac atttggaaag     60
 gatgatctca tctgtataaa agttctaaga tgatacacaa gaaatggtaa ttctgtagct    120
 tctagagagc tttatgtata gtttgtacac tgaataaatg taattggcca tccgtatgac    180
 aggaagacaa gggttttggt cggcagccat ctcaaggtga tccattgaga caaggtgcca    240
 agacctgaac aaggctgccg ccgccccagc ttgcattagg agaggaagag catcctggcc    300
 tcctccatac tggtcacacc atgtgtgtct ggggtccctc agtagctctg agggccgctc    360
 tcttaagagc atagcacact gaagctcccc taccacacac aggaagccgg agcagctcca    420
 ggtccaacag gaactgacag ccacgaggtg gaccacctgg agggcggtgc ggggaaggag    480
 gcagggccct gtgcctgaag cctgggcacc atggtggccc cagtcaggag caacagtggt    540
 agccctgagt aaaacccatt gtc                                            563



      <210> 1398
      <211> 667
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(667)
      <223> n = a,t,c or g


      <400> 1398
 tttttttttt tttttttgag tcagaaaatt attttaatag ttacaaaaat tttttttttt     60
 ttttttttac agaatcagta taaaatagca gttgatttct ccataattat cagaattatt    120
 tatacttgag gtcttggcta agtggggctg aaatcaacaa aaggtcttgg actgttggct    180
 cagaaatcat cctagaaagc ccgccctgtt gatatctgtc atgcttagct cttatgagat    240
 gacccagtcc ttannaaana aaaaaaaaaa aaaaatttta acagaatcgg tataaaatag    300
 cagttgattt ctccataatt atcagaattt atacttgagg tcttggctaa gtggggctga    360
 aatcaacaaa aggtcttgga ctgttggctg agaaatcatc ctaggaagcc cgcctgttga    420
 tatctgtcat gcttagctct catgagatgc gccagtcctt ccacctctaa ggagttctct    480
 tgtgctcttt tactccagtg ttggctccag gaccttgggt agagggtgct ggtgatatga    540
 ggtggtccag gagcaggccc gtaatgctcc ttcccaaagg aacccagaat caggtttccg    600
 tacactagat ccagcaagtt tgttcccttc ttttgacacc cttccagggt ggcacagatt    660
 tcttctc                                                              667



      <210> 1399
      <211> 537
      <212> DNA
      <213> Homo sapiens


      <400> 1399
 aaaagcggcg cggctcgttc aagatggcgg agctcgacca gttgcctgac gagagctctt     60
 cagcaaaagc ccttgtcagt ttaaaagaag gaagcttatc taacacgtgg aatgaaaagt    120
 acagttcttt acagaaaaca cctgtttgga aaggcaggaa tacaagctct gctgtggaaa    180
 tgcctttcag aaattcaaaa cgaagtcgac ttttttctga tgaagatgat aggcaaataa    240
 atacaaggtc acctaaaaga aaccagaggg ttgcaatggt tccacagaaa tttacagcaa    300
 caatgtcaac accagataag aaagcttcac agaagattgg ttttcgatta cgtaatctgc    360
 tcaagcttcc taaagcacat aaatggtgta tatacgagtg gttctattca aatatagata    420
 aaccactttt tgaaggtgat aatgactttt gtgtatgtct aaaggaatct tttcctaatt    480
 tgaaaacaag aaagttaaca agagtagaat ggggaaaaat tcggcggctt atgggaa       537



      <210> 1400
      <211> 744
      <212> DNA
      <213> Homo sapiens


      <400> 1400
 agaggccccc caagacgccc ccctgcccgc ccagctgctc ttgcaccagg gacaccgcct     60
 tctgcgtgga ctcaaaggcg tgcccaggaa cctgccctcg gaggtcatct ccctgaccct    120
 ggtgaatgcc gccttctcag agatccagga tggagcgttc tcccacctcc cgctgctgca    180
 gttcgtgtta ctcaactcca acaagtttac actgattgga gacaacgcct tcacaggact    240
 gtcgcacctg cagtatctct tcattgagaa caatgacatc tgggcactat ccaagttcac    300
 cttccgagga ctcaagtcct tgactcacct ctcgctggcc aacaataacc tgcagacact    360
 gcccagagac atcttccggc ccctggacat cctgaatgac ttggacctgc ggggcaactc    420
 actcaactgt gactgcaagg tgaagtggtt ggtggagtgg ctggcacaca ccaacaccac    480
 ggtggcaccc atctactgcg ccagcccgcc ccgcttccag gagcacaagg tgcaggacct    540
 gccgctgcgg gagttcgatt gcatcaccac agattttgtg ttgtaccaga ccctggcctt    600
 accagcagtg gcggctgagc ccttcctcta ctccagcgac ctctatttgg ctctggccca    660
 tccaggagtc agcgcctgca ccatcctgaa gtgggactat gttgagcggc agcttcgaga    720
 ctattataga atcccagccc cctt                                           744



      <210> 1401
      <211> 2095
      <212> DNA
      <213> Homo sapiens


      <400> 1401
 ctgataggcg gcctcgtcct tcagcctcag tatcgctgcc tcactggaag agccccacct     60
 gggcatgccc agcagcccct cccagctgta agtccacaca gcccccatca atgtgccatc    120
 tggggcaggc cgaggaccgg ccctggctgc cctcactgat ggctggagcc ccgatgctag    180
 ctacaatggc tggcttgagt ggacttctgt cacagaggca aatgcccaca gggcacctct    240
 tggggcaggc agggagcttg tatgtgccat ctggggccaa agctccacga ttgagtcata    300
 agttaagggt agatggagat tttccgcctt gagcagaaac gtggaggaaa cacgcctggt    360
 gtgtgactca cgcctgtaat cccagcactt cgggaagccg aggtgggcgg atcacctgag    420
 gtcaggaggt caaaaccaac ttggtcaaca tggtgaaact ctgtctctac taaaaacaca    480
 aaattagatg gctgggtggt gcacgcctgt aatcccagct gacggctgga gccccgatgc    540
 tagctacaat ggctggcttg agtggacttc tgtcaggaga attgcttgaa ctcgggaggt    600
 ggaagttgca gtgagccaag atcgtaccat tgcgctctag tctgggcgac aagagtgaaa    660
 ctcctcctca aaaaaagaaa ataagagaaa agagaagaga agaggaaaaa gaaaagaaga    720
 aaagaaacaa cccttgcagt tccccggcca ctccccagag ccagttaggc caccaggtgg    780
 gctggggcta gacccggctg cgggcgggcc acagagggac taatggccac cacttctctc    840
 catcctgcag gcagctgcca gacccggcca tcgaggacca gggtggggag tacgtgcagc    900
 ccatgctgag caagtacgcg gctgtgtgcg tgcgctgccc tggctacggc accagaacca    960
 acactatcat cctggtagat gcggacggcc acgtgacctt cactgagcgt agcatgatgg   1020
 acaaggacct ctcccactgg gagaccagaa cctatgagtt cacactgcag agctaacccc   1080
 acctctgggc ctggccagtg ggctcctggg gggccctgcc ttgaggggca ctgtggacag   1140
 gaaaccttcc tttgccatac tgcattgcac tgcccgtggc ttggccagca tcccccggat   1200
 cagggccctg tggtttgcgt gttacccatc tgtgtcccca tgcccagttc agggtctgcc   1260
 tttatgccag tgaggagcag cagagtctga tactaggtct aggaccggcc gaggtatacc   1320
 atgaacatgt ggatacacct gagcccactc ttgcacatgt acacaggcac tcacatggca   1380
 cacacataca ctcctgcgtg tgcacaagca cacacatgca aggcatatac atggacaccg   1440
 acacaggcac atgtacatgc acaggtgtgc tacacatgtg cacacatgca cagttgcaca   1500
 gacacacaca cacaggtgca cacacacgat gccgaacaag gcagaagggc gactctcacc   1560
 tctcatgtgc ttctggccag taggtctttg ttctggtcca acgacaggag taggcttgta   1620
 tttaaaagcg gcccctcctc tcctgtggcc acagaacaca ggcgtgcttg gactcttgac   1680
 aagcagacct gctcctgcag aggagacagc cacatttgga attgggcacc gagaagacct   1740
 gagaaaaacc cactctctct tttttttttt tttgagacgg agtttggctc ggccccccgg   1800
 gcgggagggc aggggcccaa tttgggttaa cggaaccccc ggcccccaag gttaaagaaa   1860
 ttctccggcc ccaccccccg gataattggg attaacgggg gggggccccc tgccccagct   1920
 atttttgggg ttttaagaaa aacgggggtt ccccctgggg ggccgggcgg gcttgaaccc   1980
 ccggaggggg gaaccccccg gcctgggccc cccaaagggc ggggtttaca ggggggagcc   2040
 cccaccccgg gccaaaaaac ccctttctat aacaaaaggg ccaacttttg ggtaa        2095



      <210> 1402
      <211> 5427
      <212> DNA
      <213> Homo sapiens


      <400> 1402
 tttttttttt tgagacggag tctcgctctg tcgcccaggc cggactgcgg actgcagtgg     60
 cgcgatctcg gctcactgca agctccgctt cccgggttca cgccattctc ctgcctcagc    120
 ctcccgagta gctgggacta caggcgcccg ccaccgcgcc cggctaattt tttgtatttt    180
 tagtagagac ggggtttcac cttgttagcc aggatggtct cgatctcctg acctcatgat    240
 ccacccgcct cggcctccca aagtgctggg attacaggcg tgagccaccg cgcccggcct    300
 cttccctcct atcattttcg tgttctggag acagtagcat acttggccct gggtttgaca    360
 taaaactagt tctacatata gaaagctagg gacaaaaatg agttctggac aaaactaaag    420
 gactgaataa tcatgtgaaa cagcccaact ctcccctaca tatgcctaag cactgatgaa    480
 gtgtttcata tattcactca cctaaatttc acaacaatcc tatgaaatgc taactagcat    540
 gatccccagt ttaaaggtga ggaaattgag tcacaggcag aataacttgc tctgggtcac    600
 caagctaata aatagatctg ggttcaaacc caggcagcct ggctccggaa tcaactctta    660
 accacttaga gcatcatcac tgagatcggg agagggacag gctgctgtaa agagggtgaa    720
 gcgaaaatgg gaggagagca gcggttaagc aatgatgtga tggggctaaa taaaaatgga    780
 tacaaaaacg agtaaaagac cagagtaaaa ggaaaagact ggagaagggg cctaacatta    840
 aaagagaatg aggagaaggg agagttgaca agcaaaggtg aaagcagaaa gtcagttgtc    900
 catatggctt ggggagataa agaaggccca ggaaggcctc caggaaaagg ctgccatgtc    960
 aggcaggaca cagaggacaa ttgaggaaaa gtgattctta caagatggtg aaggtgccat   1020
 tgtgggtgtt gggctctggc acaggcactt ggcggagcct ctgctctggg ttgagatcaa   1080
 tacatgacaa catctcatct ccgcaggtac agagctcaca tatgttggtg cttgtggagg   1140
 ccttgtgttc ctctggtgca gttaaagcct tattttgggt gtaactttca gactgcacca   1200
 gtgaatcctg agcaggttct agttcagtag gtggacctgt gacttcagtc aggcttcgat   1260
 gcagagtctg aacccggtct ggacgaggag ctgtagtctt ctccaggcct gtagaatgtc   1320
 cagtctctgt agtgggttct ggaatgatgg caagtcccag gtctggaagt tgagttgagg   1380
 tctcctccgt ggttggagac ggtttaacct ctgtagtagg ttttgtagtt atggtaagct   1440
 ccaggtccag aggttgaacg gtggcttgag tcaggtgtga atgctgagcc tgacccttgt   1500
 ctgaaggtgg aagtgtcacc tcagggtgtc ctggaggagg agctgtagtc atcagggctg   1560
 tagaaggttc aacctctgtc atggattttg gagtgatggt aaaccccagg tccaaaggtt   1620
 gaactgtggc tcgagtcagg tgtgaatgct gagtctgaac ctggtctgga tgtggaagtg   1680
 tcacctcagg atgctttgga gaaactatag tcctcttcgg gggtgtagaa tgtccaacct   1740
 ccgtagtggg ttctggagtg atggtaagtc ccaggtccaa aagttgaact gtaacgctgg   1800
 gtgacactgg atgctgagct tgatcctgac ctggtgttgg atttgttacc ccttgatata   1860
 ctcgaagttg gggtacaact ttcttaggag gctgagttgg ggtctccttc atggttggag   1920
 aaagttcaac ctctgtcatg gattctggag tgatggtaaa ccccagatcc aaaggttgaa   1980
 ctgtggcttg agtcaggtgt gaatgctctg gaggttgagc tacaactaca ttagggaact   2040
 ctggagtctg agctggggcc tcctgatggg ttagggaaga ctcaccctcc tcagcggtct   2100
 gtggatgctc agctgcagcc tcctgctggg ttggagaggg gttctcatta ttaataggtt   2160
 ccggagattt gaaatgaagt ctcctgttga actgctaaag gtccagcttc ttctgatgac   2220
 tctgaaagca gaggtgggcc cccgtgctgg atggcgggag gttctatatc attacctgac   2280
 cctgagagcc gagttgtagc ctcctgctgg actagagaag ttcccacctc tgcactaggc   2340
 tctgctgcta tggtgagctg cacgtctgga ggcttcacag agacactggg tgaatctaaa   2400
 tgatgagttt gatggtgacc tggaggtgaa actgtgactt catgatgttc tggaggctga   2460
 cctggggtct cctgctgggt cggagaagat tcgacctccc tagaagtctc agaaggctga   2520
 actggctgct gctgctcact gatggaaagt tcatgctcca taggaggaac tggaggctca   2580
 attggggcct cctgttgggt tgcagaaggt tccacctcct ctggaaactg aattggggtc   2640
 tcctgctggg tttgggaaga ttctgtctca ttggtaggct ctgaagttat ggtaacctcc   2700
 acatctgcag gtttaactgt aatgttgggc aagtgataat aagcttgatc ctcacctgga   2760
 ggttgaactg acacctcatg attcggtaga gttagactct ccatagagga ctctggaggc   2820
 agagctgggg cctcctgctg cattgaagaa ggttcttcct caaggagctg tggaagctgt   2880
 gctggggctt cttgttggag tgaagaggac tggatgtctt caagggtctc tggattttga   2940
 gtttcgggct ctagatggaa ttgagaaggt ccaacttgct cagagggccc tggaggctca   3000
 tctgacttca cccggagttc tggaggcagg ctaccgggat acggtgtatc tgtactggaa   3060
 tattcattct gcaaagtctg tttctgactc tgaggtgtgg ataattggtg tataattcca   3120
 ataatctcag caaggctcca acgctgagct ggatctttct tcagcttctt gggcgaaaca   3180
 gggagccttt cctgtggact cagcttgtcc tttaaatcct gctgtgaagc caagaactgc   3240
 tctggctcca ggggcagctc tccagctgaa tcccaggtgt ccaggaatgg aaccaaattt   3300
 tcagtcgatt cctggggtgg ggctggcatc tctgaggaag cagagggccc caggtgatca   3360
 aagtcccacg ggtctgctgg gagagtaggc gcatggggag attcccgtgg gaaatgggag   3420
 gagtgggaag accagggctc aggcggcccc agggggttag aggtcagctg gagcgggtcc   3480
 ttgacccact ccagaggctg agcctccttg actagtagcc acaatagttg ccacataagg   3540
 aggggccatg ggccccagaa acgcagcggg gacatgacac acgctagtgc cgggcactga   3600
 gcggaagtca ttctggcagc tccgagacgc tcgtgcccct tgtaagcatg agtcccgccc   3660
 tgtctttatg acacctttat ttatgccaca gaactgctcc atgtcaccag ggcactctta   3720
 tgtcacaatc ccgcccaagc acgccttccc atcctgccct gccggagcac ccctctcctc   3780
 cccttagtga ggaaggattt gggcctcaga tcctggtggt cccaggactc cagcgcctgc   3840
 tgtggtgggg tagggtgggg tagggtggga tgggggcgcg gcagagcttc ccaaggaagt   3900
 caccggacct cgcctcagga tattcagaag tgctagttca gttctggcag ccttcctcct   3960
 ttaaggtgaa atccgagaac actcttcctt ccagggagag caactgacct gcaaaatggg   4020
 cgccaggatg tacattacag tcatttattc caaagtgttg ccattttcgc taaactgtcg   4080
 catgtttgat aattaattca ccaccctatt aggtaggggc tgccagggaa taagcgagga   4140
 ctccaaattt tctgtaggag gggtgttggg agttggcaat tcggtctggg agagaaggtt   4200
 ttaatccgag tgaagagccc tttgcactag cctgggagga ggctgaactg tcatcctgcc   4260
 ttgactcaac acagccattc ccctagaagt tacagcactt ctagggtcac ctgtgttcag   4320
 agatctaccc tgtgtgcaca catggagaag aggcttaggt tgttaaagtc agcatgttaa   4380
 atcatttcct gaaatgcgac tgtaactaga acccagctga cttcccccac agccgttctt   4440
 acctatttta ttactgtctg gcataattac cagcatgtaa actccaagaa ggtgcttcat   4500
 cttattttag tgcctggcat agacataggg tgcatagtga tggctttaaa attgaagggg   4560
 ggccgggcgc agtggctcac gcctgtaatc ccagcacttt gggaggccga ggcgggtgga   4620
 tcacgaggtc aggagatcga gaccatcctg gctaacaagg tgaaaccccg tctctactaa   4680
 aaatacaaaa aattagccgg gcgcggtggc gggcgcctgt agtcccagct actcgggagg   4740
 ctgaggcagg agaatggcgt gaacccggga ggcagaggtt gcagtgagcc gagatcacaa   4800
 cactgcactt cagcctgggc aacaagagag aaactccatc tcaaaaaaat aaaataaaat   4860
 aaaatggaag agattccaag attcacctca tttagggatg gagctattat tataatcaga   4920
 tttctgaaat gagtgctgac ttcctctcac atttcacagg aagctagact tcttaaagct   4980
 tgaagtctcc ttggtgggtt ttatttaaat tgaattaaaa taattatttt acagggaaaa   5040
 atttcaaaac actttgcaac tttggggtaa aagttaaata aaacactgta gccccaagtt   5100
 aagttcccac tgaaatgata cttttgctcc tttttttaaa aaaaattcca taaatagtaa   5160
 ataatgactg ttttgagatt aatttagaaa caatccctat ttaagagctt tcatatgcag   5220
 tcatgcattg cttgccacgt gaggagcttg agaaatgggt cactaggtta tttcaccatt   5280
 gtgctaatat catagcgtat acttacacaa acctaggtgg tgtagccacc atacctaggg   5340
 tacacggtat ggcttaggac tcctaggcta caaacctgta ctgtatgtta ctgtactgaa   5400
 tactaaaggc aactgtcaca gaatggc                                       5427



      <210> 1403
      <211> 1512
      <212> DNA
      <213> Homo sapiens


      <400> 1403
 ctgagagtga gaacagtaat acgttcagat ctaagagtgg gaaagatgcc agttttgagt     60
 ctggagctgg ggataacacc agcatcaagg ataagtttga ggctgctggt ggagttgata    120
 tagggtcttg gttctgtgct ggtaatgaaa acacaagtga ggacaaatct gcacctaagg    180
 ctaaagccaa aaagtcatct gagtcaagag gcatatatcc gtacatggtc cctggggcag    240
 gaatggggtc atgggatgga gccatgatct ggtcggaaac taagtttgca catcaaagtg    300
 aggccagctt cccagttgaa gatgagtcca gaaaacaaac caggactggg gaaaaaactc    360
 ggccctggtc ttgccgctgt aaacacgaag ctaatatgga tccacgagat cttgaaaaac    420
 tcatttgcat gattgagatg actgaagatc cttctgttca tgaaatagcc aataatgctt    480
 tatataacag tgctgattat tcttattctc atgaagttgt tcgtaatgta ggtggaattt    540
 cagttattga aagcttgctc aataatccct accccagtgt taggcagaag gctttaaatg    600
 cactgaataa tatctcagtg ggctgctgaa aaccatagga aggttaaaac ttacttaaac    660
 caagtatgtg aagacactgt cacctatccc ttgaattcaa atgtgcagtt ggctggacta    720
 aggttgataa ggcatctgac tattaccagt gaatatcagc atatggttac aaattatatt    780
 tcagaatttc ttcgtttgtt aacggtgggg aagtgggaga aacttaaagg accctgtttt    840
 tgggaatgct tttgaatttc tctaaaaatc catctatgac aaaagacttg ctcattgcca    900
 atgcaccaac atcacctgat taacattttt agcaagaaag agacaaagga gaatattctt    960
 aatgctcttt cactatttga aaatataaat taccatttta aaagaagagc aaaagcattt   1020
 accccaggga caaattcagt aaaaattccc tttatttcct attccaacga cctaaagcat   1080
 gtgccaagaa acttcgagcc ttagcagcag aatgcaatga ccctgaggtg aaagagagag   1140
 ttgagctatt aataagtaaa ctctgattgg ctgtatgttc ccaaacaaat ttgagtaata   1200
 ttttggtttt gcactctgga agtaatgcac attgtaaatt gcattataac tttgaaactg   1260
 atgttaccta tgatggtcta tagctggaac catttaatgg aacaccaaat gaattcaagc   1320
 ttgtactaaa aatacatgtg ttgattttta tcttgtctgg attgagatat ttttagtatg   1380
 cttcatgagc agaaactgaa tggattcttc ataagtaagg taatctttgg tcctttgtgt   1440
 ggacttatgt ttatacattt aagactattt ttatgtcatc aataaagttg tgtgttttaa   1500
 gcagcagaaa aa                                                       1512



      <210> 1404
      <211> 4670
      <212> DNA
      <213> Homo sapiens


      <400> 1404
 gtgtgggagg tcgttcagtg tcatctcaga atttgttgag caccagatca tgcatactag     60
 agagaacctc tatgagtatg gtgagtcctt tatccacagt gtggctgtca gtgaagttca    120
 gaaaagtcag gttggaggga aacgttttga atgtaaggac tgtggagaga ccttcaataa    180
 gagtgccgcc ttggctgaac atcggaagat tcatgctaga ggttatcttg tggaatgtaa    240
 gaatcaggaa tgtgaggaag ccttcatgcc tagccccacc tttagtgagc ttcagaaaat    300
 atatggcaaa gacaaattct acgagtgcag ggtgtgcaag gaaaccttcc ttcatagttc    360
 tgccctgatt gagcaccaga aaatccactt tggggatgac aaagataatg agcgtgaaca    420
 tgaacgtgaa cgtgaacgtg agcgcgggga aacctttagg cccagcccag cccttaatga    480
 gtttcagaaa atgtatggta aagagaaaat gtacgaatgt aaggtgtgtg gggagacttt    540
 ccttcatagc tcatccctga aagaacatca gaaaatccat actagaggga acccatttga    600
 aaacaagggt aaagtgtgtg aggaaacctt tattcctggt cagtccctta aaaggcgtca    660
 gaaaacttac aataaggaga agctctgtga ctttacagat ggccgggatg ccttcatgca    720
 aagctcagag ctcagtgagc atcagaaaat tcattctcga aagaacctct ttgaaggcag    780
 agggtatgag aaatctgtca ttcatagtgg gccattcact gaatctcaga agagtcatac    840
 tataacaaga cctcttgaaa gtgatgagga cgaaaaggcg ttcaccatta gctctaaccc    900
 ctatgaaaac cagaagattc ccactaagga aaatgtctat gaggcaaaat catatgagag    960
 gtctgttatt catagcttag cctctgtgga agctcagaaa agtcacagtg tagcagggcc   1020
 cagtaaacca aaagtaatgg cagagtctac cattcagagc ttcgatgcta tcaaccatca   1080
 gagagttcgt gctggaggga acacctctga aggaagggaa tacagtaggt ctgttatcca   1140
 tagcttagtg gcttccaaac ctccaagaag tcacaatgga aatgaattgg tggaatctaa   1200
 tgagaaggga gaatcctcca tttatatctc agaccttaat gataagcgac agaagattcc   1260
 tgccagagag aacccttgtg aagggggcag taagaatcgc aactatgaag actctgtcat   1320
 acagagtgta ttccgtgcca aacctcagaa aagtgttcct ggagagggat ctggtgagtt   1380
 taagaaggat ggcgaattct ctgttcccag ctcaaatgtc cgtgaatacc agaaggctcg   1440
 tgctaaaaag aaatacattg agcataggag caatgagacc tctgtaattc actctctgcc   1500
 ttttggtgaa caaacatttc gccctcgagg gatgctctat gaatgtcagg agtgtgggga   1560
 gtgctttgct catagctctg acctcactga gcaccagaag attcatgata gggagaagcc   1620
 ctctggaagc agaaactatg aatggtctgt cattcgcagc ttggccccta ctgaccctca   1680
 aacaagttac gcccaagagc agtatgctaa agagcaagcg cggaacaaat gtaaggactt   1740
 cagacaattt tttgctacca gcgaagacct caacacaaac cagaaaatct atgaccaaga   1800
 gaagtctcat ggcgaggagt ctcaaggcga gaatactgat ggggaggaga cccacagcga   1860
 ggagacccat ggtcaggaga caattgaaga ccctgtcatt caaggctcag acatggaaga   1920
 ccctcagaag gatgaccctg atgacaaaat ctatgaatgt gaggactgtg gcctgggctt   1980
 tgtggatctc acagacctca cagaccatca gaaagtccac agcaggaagt gcctggttga   2040
 cagtcgggag tacacacatt ctgtaattca cacccattcc atcagcgagt atcagagaga   2100
 ttacactgga gagcagctgt atgaatgtcc aaagtgtggg gaatctttta ttcatagctc   2160
 attccttttc gagcatcaga gaatccatga acaagaccag ttgtattcca tgaaggggtg   2220
 tgatgatggt tttattgccc tcttgcccat gaagccacgg aggaatcgtg ctgcagagag   2280
 gaatcctgct cttgctgggt cggccattcg atgccttttg tgtggacaag gcttcattca   2340
 tagctctgcc cttaatgagc atatgagact tcatagggaa gatgatttac tggagcagag   2400
 ccagatggct gaggaagcta tcattccagg cttagccctc actgagtttc agagaagtca   2460
 gaccgaagag agactctttg aatgtgcagt ctgtggagaa tctttcgtca acccagcaga   2520
 acttgcagat cacgtaactg ttcataagaa tgagccctat gagtacgggt cctcctatac   2580
 tcacacctca tttcttactg agcccctcaa aggagctata ccattctatg aatgcaagga   2640
 ttgtggtaag tcctttattc atagcacagt cctcactaaa cataaggagc ttcatctgga   2700
 agaagaagaa gaagatgaag cagcagcagc tgcagcagca gcagcccagg aagttgaagc   2760
 caatgtccat gttccacaag tagttctgag gattcagggc ttaaacgtag aggctgctga   2820
 gccagaagtg gaggctgccg agccagaagt ggaggctgct gagccagaag tggaggctgc   2880
 tgagccaaac ggagaggctg aagggccaga tggagaggct gcagagccca ttggagaggc   2940
 tggacagcca aatggagagg ccgagcagcc aaatggggat gctgatgagc cagatggtgc   3000
 aggtattgaa gacccagaag aaagagctga agagccagag ggaaaagctg aagagccaga   3060
 gggagatgcc gacgagcctg acggtgtggg aattgaagac ccagaagaag gtgaagatca   3120
 agagattcag gtagaagaac catactatga ctgccatgaa tgcacagaaa ccttcacttc   3180
 cagcacagca ttcagtgaac acctgaaaac tcatgccagc atgatcatat ttgagcctgc   3240
 aaatgccttt ggggagtgct caggctacat cgaacgtgcc agcaccagca caggtggtgc   3300
 caatcaagct gatgagaagt acttcaaatg tgacgtctgt gggcagctct tcaatgacca   3360
 cctgtccctc gccagacacc agaataccca cactggctga gggcatgggg taaaggttag   3420
 aaaaccttca cctaggactt gacccttacc aaaccacaga gaatccaaac caatccatga   3480
 taatgtcagt aggagactta accttagtgt gttacacacc tgacttaaca tctctaaact   3540
 cagattgaaa agagaccgaa tgtgcagatt ccacagtctt aagctttccc cttcagatgt   3600
 cagtgtctgc atgtgggaaa gccatagcac acatcttacc tttccaagta atcagattga   3660
 gaaaacccta tgagtattcc agactacaga gtttgcccaa atcaactgta aatgacactt   3720
 gtgtaacgta tatatagtgt ttcatgaggt gtatataaaa tagcaaatta tgacagaaca   3780
 gtgatcacat atatttggat ttatatgata tacagttaca gtttactctg cagaggtacc   3840
 ttacctggta ttctttgaat tttttttttt tttggggggg gaaaagagca ccaaatttga   3900
 ttatattttt aagggcctaa aatcctgaaa aaaatttatt gggcattatt tgaaccctgc   3960
 caatatcttt ttgagaaatg gtttggtttc ttacccttaa aaagtcttgt gaagctgtag   4020
 gcatgaaaaa aaacagggct tttactcctt actgtttgaa aagataagta ctttagtttt   4080
 tttttgcagc catttcatct gcgccaacac tttggaacct aatactgtgt aaggctttac   4140
 aatatacgga ttggcttttt gtgacccaga ttgattggtt gccacatgtt atgtttgttg   4200
 aagtggttct catgcaaaaa tattacacat ttgtgttctg ggtttttttt ttttttttta   4260
 acccaactca atatgtgttt ggatgatagt gaattgataa aaccccggaa gcttttcccc   4320
 tgtaaatctt accatctttt gccttttaaa gaatgggtta caaccatcac tagatcacag   4380
 tagtgcctaa tgaaggttga gaaccgtagg agaggctctc atgctgtaaa taatgttgca   4440
 ggctaataac ctttcatcac ttcctttgtg cgcttcctgc cttaagtgac aagtagcaac   4500
 atggcttggg tcccctgtgc agcatcagct tatgctgcca caagtcagtt tgcaccctag   4560
 gtgcccagga gctagtatcc ttagatcttt ctatcgctaa cttaattctc ttcgttattt   4620
 atcctgaccc ctcctaactc ccatgtccta accttgcatt aaaaaaaaaa              4670



      <210> 1405
      <211> 1372
      <212> DNA
      <213> Homo sapiens


      <400> 1405
 acttattaag tgcctgacaa cggagatgta acgaaattgc ctgtctgctc cactctggtt     60
 gaagaaacca gtctgactgt ctctgaggct atggagcagt ccatcaagaa tgaaagccct    120
 ctgccaggca cgttggctca cacctgtaat accagcactt tgggaggccg aggcaggtgg    180
 atcacttgag gtcgggagtt cgacaccagc atggccaaca tggtgaaacc ctgtctctac    240
 agaaaataat actttgcaag gcctcagaaa ctctgctatc cacaggcagg tcttacagtc    300
 atggctggct gcctctctct gagaactggg actcctgaac ttggtgaaat acctcagcca    360
 ttgatcatgt taaattatcg gtggcactca tttaaaatcc gagtctgctc cagatggact    420
 ctctctttct gccctgacta tgagagagag agatcgtgag agacagagac catgagaaag    480
 accgtgagag agagacacag agctagagag agagaccgtg tcctgacctg ctggacagtg    540
 gagatgcttg tgggctgtga gcaagggatg caaaggctgc cgggaatccc atttttccag    600
 catcatctgc caaggcacat cagttcctgg gtgtcttgat gggttctggc agcattactg    660
 tcattgaagg aaaacatttt agccatatta aaggttaatg cagcaatctc cacataggct    720
 gcctggaagg gaagcaggac aaggttaggt tttccttgtg atggacagga ggcaggcggc    780
 cctcccacag ccctgcctgg caatacagat gtgtccccaa aaggcactgg gggccagctg    840
 gagtgctatg ccgaggcgga ctgacccggg ccgtgggttc actctgctgg cagcggtttc    900
 ccgccagctc cttgcagagt tggcagatgg cccagcccca cagcaggagc cgggaatggc    960
 agaacgagac acaacaattt gatatccact tgccagatga gccgggtgtc atcagtcgcc   1020
 tggctctatg cccaacctct ttttgcataa acacttatgg attcagccaa gaggaaaagc   1080
 actctgatta tgaattgagc agaaggaaac aaagttctgc agataaacac caatgaaaca   1140
 aaaaaccacg aataagaaaa atgacagaaa aggagaacct tcccagaatc ctcctgccag   1200
 tgaacggtca ccagagcaag agcatggagt ccctgggttt tgaactgtga gataaggaag   1260
 atgatgaaaa cctccctagc agccagactt agatttttgg ctggactatt ggcttgggat   1320
 agatgaaaat cattccttgt atcccctgat cttaaagtca agactgaacc ag           1372



      <210> 1406
      <211> 474
      <212> DNA
      <213> Homo sapiens


      <400> 1406
 ttatgtctat tagtccagtg cggtggaatt cgaaggaggc aggcagggca gcaaacaggc     60
 agtttccttc cttctctccc tggaaagatg acagccgtga cgccagtcct cctgagcccg    120
 ccagccccac catcggcctc gataagaaga ctcgccgaaa gttcctggac ctgggggtca    180
 ccctgcgccg agcatccacg ggcaagagcc ggaaggagaa aggcagcaac cgactgtcca    240
 tgggcagcag ggagtcagtg gaggggtccg gcaggtcagg gggctccccg ttcctgcctt    300
 tttcctggtt cacggacagc ggcaagggct cagcatcctc gggtagcacc acctccccca    360
 cctgctcccc taaacacgag ggcttcagcc ctaagaagtc agcttcccag gaatccactc    420
 tgagtgatga ctccacgccc cccagcagca gccccaagat ccccagtggg ccct          474



      <210> 1407
      <211> 3289
      <212> DNA
      <213> Homo sapiens


      <400> 1407
 gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta     60
 ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt    120
 cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc    180
 cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca    240
 acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc    300
 cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg    360
 acatgattac gaatttaata cgactcacta tagggaattt ggccctcgag gccaagaatt    420
 cggcacgagg tttttttttt tttaagtggg acaattaaaa atttaaaaaa taattttaaa    480
 atagaacagc ttagagatag gaaacctaaa tttatttccc aattccttac tgtgccccca    540
 aaaccagggt tcaccaaaag ggctgtcctc ccaacaattt tctgaattct atatattcag    600
 cattaaattc catgataaag ttggaaatcc attcaccatt tgtaatacat attgatgcat    660
 ttaataaaat tgcatgggcc gtatcttttg catttctgta tcctagtatt aagtacagtg    720
 cctaccacag gccaggttct caatacttga ataaatgaca caaaaatagc caggaccagc    780
 aagttttttc tgggtgggct tcatagaatc tctgtacttg ctggaatcac catgaaatcc    840
 atggtcttca gctttgcatt ttcagcaaca tagttatatt gagttatcct caggtgagca    900
 gtgagaccct tgggagcgga ttcatggtag ggtggctttg taatgtgtca ccttggtgag    960
 gctatgtttc ccggaactct cttccagtaa gatgggccac aagagacatt ttgcttgata   1020
 accggagggc ggaagtgaag cagcagcaca ttgtttttac acttggaagg ttggtgctgg   1080
 ggcaccaggc gttgttgcag ttcacacgtt gccatgtatc tgctagatca cctcgttggt   1140
 gtgggcagta gtcaggcctg cagccaggcc tgcagctgct ccaccttccc caggatcatc   1200
 ctttcagctt ctctaattcc tgggccagat gcatatttaa ctctgtgagg aagggcacca   1260
 gcttcttctg caggacaccc acatcatcga agctggaggt ggtgagagac tgacatgggt   1320
 tccaggccat cctcgtgggt tccagctcgt gctcgtgggc tccactgtgt cctcggtctc   1380
 ccacacttta catccatctt cccttcccga gtgcctgccc tgcagacttg aatcctacag   1440
 tctgtagaag cctccagtca actgctttct agctccaggt tttttaaggt ctttggacct   1500
 tggcaaccag actgctgtat ctcggaagcg ggttccaccc aggctgaaaa tctccgtgat   1560
 cacgggtgtg ccagcccctc ctgcctcttc ctctggggcc aatttggagg cagaatcatc   1620
 cttgttctcc tccttgtcct cctctgggtc aggtggctct tgcttcacag aaggcaggcc   1680
 tgggtctact gccttgctag ggcagccagg caccaatacg ggagaagtca ggacagctgt   1740
 gcctggtgtc cactcgtcct gggtatccgc cttctcttgc ttcacctggg gtaaggccac   1800
 aacccaactc atgccagaac actgggcytc ctgcaacagg gcttctgtgg aagctgcaac   1860
 agggcccggc acctgcacag gamtgcttgc gcccttcccg taaaaaacac aaggttcagt   1920
 gcccaggcgg gggcagcaca aagccaccac ctgcttcctg cttcgttgga gcctgggtat   1980
 ggtctggttg ggctgtgcgt gtagccaagg tgggcttcaa ggtagggcca agatggtgcc   2040
 gtcgggcaga gctgggcctc tttcgacgac ggtaaggtgg gggcgatcct gccccatcct   2100
 cagactctga ccagacactg ggcagcagcc gcttcatggc aaactgcagg cattggcgcc   2160
 aacgacactt ctggcgcttc tggttgctgc ccccgaattt gggcttgtcg cagcagaagt   2220
 cgcagcggcc acatccattc cgccgtaggc aggctgcaca ggccccgcac ttgcggttct   2280
 gccggcggtt cgtgtagggc tgtagctcgt cctcgtctac acagtaatag atgaactcgg   2340
 caggtggcga gggggccagg gctctggggt gcggctctgt gggctctggg gactgtgatg   2400
 ggggtggtgg aggcagtggc tgggctccgg ggcgccgcct ggcagccatc ttggagtcac   2460
 agcctccctt gcggcgggca tgtttacccc gtaggcaacg tcgctggaca catttccact   2520
 ggcgcctgag accagggcgg ggagggcgaa ggcagatggg gcaatggcca caatcytctt   2580
 gggtctgaca gccccggcat actccacacc ctcggctctt aaacattctc tgttcccggt   2640
 tgaaggcaat tctctgtgct cgacagtctt tgcacaacgt tttgagccgc tgcctttggg   2700
 tgccatcccc tgagaagctg attccacagt tctcacagca cccaggagca gggaatgaag   2760
 ctggggctgt gtcagtgtca gccttggtct catccctcgg ggcctccttc ctgacctcac   2820
 cactctgggg tccaacctga cgtttccgag tcttggctgg ccttgaaggc ttctttcgct   2880
 tcttgctggc aaccgccacg ggatgggcct tgggggctgg atagcacaag atgccttgtt   2940
 tgaagtcgaa gagggtgaga tcacacgcag ggcccaggta tcgagtcagc tcaactttgc   3000
 ttcggatcct gtctcctgtg gggctctggt aataggtgtc tgagcgtcca caggtggccc   3060
 ctgacttgcg aaagacttcg cggcgcttcc agccagggcc cagggccggg cagtccagcc   3120
 agtcctcagc catggaggcc acaggaagca gcagtagcca gtttggcacc aggccggtat   3180
 cttccgccac tctaggcccg tggacccatg gcgagggtcc ctcctgcacc tcccgcctcg   3240
 ccctcctccc cttcctcctc ctccgcggcc ggggggagta tcacacaaa               3289



      <210> 1408
      <211> 662
      <212> DNA
      <213> Homo sapiens


      <400> 1408
 gctaaagaac agctctgagt ggcaacgagc aggaaaagca gctcacagag cagcctccag     60
 gcaccaagac cgtgaggcca catcgcctcc agggagcagg tcccacagca cccctacccc    120
 agggcaccag gactgggtta ttccgggatt tcgcagtgct gagaactttg gagaacaaaa    180
 tccccggcag ctgcctgaac gctgaacgga ggtggcgcga tccgcctgat gaatcaggct    240
 aattacacag aagccacaca ggttttgctt cctccaggaa aactgctttc cctctttaat    300
 attcactatc ctcttctcac agcctgtaag cctcgctcaa attagggtgc agctgcaacc    360
 caaacccaaa attaaatgcc caagcacgcg acagggacac acacggctcc agatacaccg    420
 gccccgcccg cctcctctcc acagcctggg tgctagcagg caaagaagtc agggaagatg    480
 ctctccacct cgtccttcag ggccaggcct gcacagtcca catccaggcc ccacggctcc    540
 agagggctgt cctggagctc ctgggagcca agctcagggt cccctaggaa gcctggctct    600
 ccaacatcca gtggactgct ctcagctggg gcccatgcag ggccactgtc tcctcgaccc    660
 tt                                                                   662



      <210> 1409
      <211> 5186
      <212> DNA
      <213> Homo sapiens


      <400> 1409
 atggtctcag cccaaaatct ccttaagctg ataagcaact tcagcaaagt ctcaggagac     60
 aaaatcaatg tgcaaaaatc acaagcattc ctctccagca acaacaggca aacagagagc    120
 caaatcatga gtgaactccc attcacactt gctacaaaga gaataaaata cctaggaatc    180
 caatctacaa gggaagtgaa ggacctcttc aaggagaact acaaaccact actcaatgaa    240
 ataaaagagg ataccaaaaa aatggaagaa cattccatgc tcatggatag gaagaatcaa    300
 tattgtgaaa atggccatac tgcccaagaa gggaaaactt aacaaacaga aaggacaacc    360
 acacccaaaa acccatcttg tacatcaccc atcattcaaa gacccaaaag taaataaaac    420
 ccaccaaaga tggggaaaaa aacagaacag aaaaactgga aactctaaaa tgtagagtgc    480
 ctctcctcct ccaaaggaaa gcagttcctc accagcaacg gaacaaagct ggatggagaa    540
 tgactttgac gagctgagag aggaaggctt cagacgatca aattactccg agctacagga    600
 ggaaattcaa accaaaggca aagaagttga aaactttgaa aaaaatttag aagaatgtat    660
 aactagaata accaatacag agaagtgctt aaaggagctg atggagctga aaaccaaggc    720
 tcaagaacta cgtgaagaat gcagaagcct caggagccga tgcgatcaac tggaagaaag    780
 ggtatcagtg atggaagatg aaatgaatga aatgaatgaa atgaagtgag aagggaaggt    840
 tagagaaaaa agaataaaca gaaatgagca aagcctccaa gaaatatggg actatgtgaa    900
 aagaccaaat ctacatctga ttggtgtacc tgaaagtgat ggtgagaatg gaaccaagtt    960
 ggaaaacact ctgcaggata ttatccagga gaacttcccc aatctagcaa ggcaggccaa   1020
 cattcagatt caggaaatac agagaacgcc acaaagatac tcctcgagaa gagcaactcc   1080
 aagacacata attgtcagat tcaccaaagt tgaaatgaag gaaaaaatgt taagggcagc   1140
 cagagagaaa ggtcgggtta cccacaaagg gaagcccatc agactaacag cggatctctc   1200
 ggcagaaact ctacaagcca gaagagagtg ggggccaata ttcaacattc ttaaagaaaa   1260
 gaattttcaa cccagaattt catatccagc caagctaagc ttcataagtg aaggagaaat   1320
 aaaatacttt acagacgatc aaatgctgag agattacata atggtaaagg gatcaattca   1380
 acaagagctc ctgaaggaag cgctaaacat gcacccaata caggagcacc cagattcata   1440
 aagcaagtcc ttagtgacct acaaagagac ttagactccc acacattaat aatgggagac   1500
 tttaacaccc cactgtcaac attagacaga tcaacgagac agaaagtcaa caaggatacc   1560
 caggaattga actcagctct gcaccaagca gacctaatag acatctacag aactctccac   1620
 cccaaatcaa cagaatatac atttttttca gcaccacacc acacctattc caaaattgac   1680
 cacatagttg gaagtaaagc actcctcagc aaatgtaaaa gaacagaaat tataacaaac   1740
 tgtctctcag accacagtgc aatcaaacta gaactcagga ttaagaaact cactcaaaac   1800
 cgctcaacta catggaaact gaacaacctg ctcctgaatg actactgggt acataacgaa   1860
 atgaaggaaa aaataaagat gttctttgaa accaacgaga acaaagacac aacataccag   1920
 aatctctggg acacattcaa agcagtgtgt agagggaaat ttatagcact aaatgcccac   1980
 aagagaaagc aggaaagatc caaaattgac accctaacat cacaattaaa agaactagaa   2040
 aagcaagagc aaacacattc aaaagctagc agaaggcaag aaataactaa aatcagagca   2100
 gaactgaagg aaatagagac acaaaaaacc cttcaaccct tcaaaaaatt aatgaatcca   2160
 ggagctggtt ttttgaaagg atcaacaaaa ttgatagacc gctagcaaga ctaataaaga   2220
 aaaaaagaga gaagaatcaa atagacacaa taaaaaatga taaaggggat atcaccactg   2280
 atcccacaga aatacaaact accatcagag aatactacaa acacctctac gcaaataaac   2340
 tagaaaatct agaagaaatg gataaattcc tcgacacata caccctccca agactaaacc   2400
 aggaagaagt tgaatccctg aatagaccaa taacaggagc tgaaattgtg gcaataatta   2460
 atagcttacc aaccaaaaaa agtccaggac cagatggatt cacagccgaa ttctaccaga   2520
 ggtacaagga ggagctggta ccattccttc tgaaactatt ccaatcaata gaaaaagagg   2580
 gaatcctccc taactcattt tatgaggcca gcatcatcct gataccaaag cctggcagag   2640
 acacaacaaa aaaagagaat tttagaccaa tatccctgat gaacatcaat gcaaaaatcc   2700
 tcaataaaat actggcaaac caaatccagc agcacatcaa aaagcttatc caccatgatc   2760
 aagtgggctt catccctggg atgcaaaaat cctcaacata tgcaaatcaa taaacataat   2820
 ccagcatata aacagaacca aagacaaaaa ccacatgatt atctcaatag atgcagaaaa   2880
 ggcctttgac aatatatgca aatcaataca tgcaataaat taggtattga tgggacatat   2940
 ctcaaaataa taagagctat ttatgacaaa cccacagcca atagcatact gaatgtgcaa   3000
 aaactggaag cattcccttt gaaaactggc acaagacagg gatgccctct ctcacctcac   3060
 cactcctatt caacatagta ttctgcccca tagtgttctg gccagggcaa tcaggcaaga   3120
 gaaggaaata aagggtattc aattaggaaa agaggaagtc aaattgtccc tgtttgcaga   3180
 cgacatgatt gtatatctag aaaaccccat tgtctcagcc caaaatctcc ttaagctgat   3240
 aagcaacttc agcaaagtct caggatacaa aatcaatgta caaaaatcac aagcattctt   3300
 atacaccaat aacagacaaa cagagagcca aatcatgaat catgagtgaa ctcccattca   3360
 caattgcttc aaagagaata aaatacctag gaatccaact tacaagggat gtgaaggacc   3420
 tcttcaagga gaactacaaa ccactgctca gtgaaataaa agaggataca aacaaatgga   3480
 agaacattcc atgctcatgg gtaggaagaa tcaatattgt gaaaatggcc atactgccca   3540
 aggtaattta tagattcaat gccatcccca tcaagctacc aatgactttc ttcacagaat   3600
 tggaaaaaac tactttaaag ttcatatgga accaaaaaag agcccacatt gccaagtcaa   3660
 tcctaagcca aaagaacaaa gctggaggca tcacgctacc tgacttcaaa ctatactaca   3720
 aggctacagt aaccaaaaca gcatggcact ggtaccaaaa cagcatggta ctggtaccaa   3780
 aacagagata cagaccaatg gaacagaaca gagccctcag aaataatgcc gcatatctac   3840
 actattctga tcctttggac aaacctttgc ttgagaaaaa caagcaatgg gggaaaggat   3900
 tccctaattt ataaaatggc tgctggggaa aactggctag cccatatgta ggagaaagct   3960
 gaacctggca tcccttccct taccccttat acaaaaatca attcaagatg gattaaagac   4020
 ttaaatgtta gacctaaaac cataaaaacc ctagaagaaa acctaggcaa taccattcag   4080
 gacataggca tgggcaagga cttcatgtct aaaacaccaa aagcaatggc aacaaaagcc   4140
 aaaattgaca aatgggatct aattaaacta aagagcttct gcacagcaaa agaaactacc   4200
 atcagagtga acaggcaacc tacagaatgg gagaaaattt tcgcaaccta ctcatctgac   4260
 aaagggctaa tatccagaat ctacaatgaa ctcaaacaaa tttacaagaa aaaaacaaac   4320
 aaccccatca aaaagtgggt gaaggatatg aacagacact tctcaaaaga agacatttat   4380
 gcagccaaaa gacacatgaa aaaatgctca tcatcactgg ccatcagaga aatgcaaatc   4440
 aaaaccacaa tgagatacca tctcacacca gttagaatgg caatcattaa aaagtcagga   4500
 aacaacaggt gctggagagg atgtggagaa ataggaacac ttttacactg ttggtgggac   4560
 tgtaaactag ttcaaccatt gtggaagtca gtgtggcgat tcctcaggga tctagaacta   4620
 gaaataccat ttgacccagc catcccatta ctgggtatat acccaaagga ttataaatca   4680
 tgctgctata aagacacatg cacacgtatg tttattgcgg cactattcac aatagcaaag   4740
 acttggaacc aacccaaatg tccaacaatg atagactgga ttaagaaaat gtggcacata   4800
 tacaccatgg aatactatgc agccataaaa aatgatgagt tcatgtcctt tgtagggaca   4860
 tggatgaaat tggaaaccat cattctcagt aaactatcgc aagaacaaaa aaccaaacac   4920
 cgcatattct cactcatagg tgggaattga acaatgagat cacatggaca caggaagggg   4980
 aatatcacac tctgggggac tgttgtgggg tggggggagg gggggaggga tagcattagg   5040
 agatatacct aatgctaaat gacgagttaa tgggtgcagc acaccagcat ggcacatgta   5100
 tacatatgta actaacctgc gcattgtgca catgtaccct aaaacttaaa agtataatta   5160
 aaaaaaaata aaataaaaat aaaaaa                                        5186



      <210> 1410
      <211> 418
      <212> DNA
      <213> Homo sapiens


      <400> 1410
 ataatttaga ttgtggactt agttacaggg ttatttctta ccttaaaaaa ctcagccaac     60
 agaccaaact agagtcagaa cgaatactag catcagtggg gaagaaacct ccccaggaaa    120
 ttggaattaa agtgaaaaat cattctggag gtggcatgtc cttgactcac aataaaaatt    180
 ttagaaaact attgaaagaa atcacagggg aaactgcact tagactgaca gaattgaaca    240
 ccaaagaatt tgctggcttc caaattgggc tcttaaacaa ggatttgaaa cctcagacat    300
 acagaaatgc ttatgatatt ccccgtagag gtcttttaga ccagctgacc agaatgagat    360
 ccaatctgct gaaaacgcac aagtttattg ttggacaaga tgaagattcc cttcatag      418



      <210> 1411
      <211> 1913
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1913)
      <223> n = a,t,c or g


      <400> 1411
 tttcgtccgg aacggcggca cggggttgtt gtgggggtca gtcccccggg gactggaggg     60
 agacgcggca cgcggcctct gcgaccctat gaactctgac cccagctccc acactgtcgc    120
 ctatcaccgg cccactctcc gtgccgcgtg tcccttaaaa gctggggcct gggacaggaa    180
 cgacagacaa tgcagccaat ggcgtcacgc gcggtgcccc gctacccaat cgaaaggcgt    240
 ggctgaggga aacgcggtgg gaaccgcccc cgactccagg cgactccttg gccgggcggg    300
 ggagagcgtc cccgtcagct gagagcatcc tcactcggtc agttcctcgg gcgagttacg    360
 gggacgacct gcgggagcac gcgggcagtg gccggacgct gaagcccagg agagcgatgg    420
 agacgtatgc ggaggttggg aaggagggca agccttcctg tgcatcggtg gatctgcagg    480
 gagacagctc cttacaggtg gagatttctg acgcagtgag tgagcgggac aaggtgaaat    540
 tcactgttca aacaaagagc tgcctccctc acttcgccca gaccgagttc tcagtcgtgc    600
 ggcagcacga ggagttcatc tggctgcatg atgcctacgt ggagaatgag gagtacgccg    660
 gcctcatcat ccccccagcc cctccgaggc cagactttga ggcttcgagg gaaaagctac    720
 agaaattggg cgagggggac agctctgtca ctcgggaaga gtttgccaag atgaagcagg    780
 agctggaagg nagtacctgg ccatctttaa gaagacagtt gcgatgcacg aagtctttct    840
 gcagcgcctg ggcggcccac cccaccctgc gtcgagacca caacttcttt gtgtttttgg    900
 gaatatggga caggatctga gtgtccgggg gaaggaacag gaaggagctc ctcggagggt    960
 ttctgaggga tattgttgaa gttccgcgga tgaagccctc atcacgggca tgtcagggct   1020
 caaggaggtg gatgacttct ttgagcatga gaggacaaac ctgttggagt atcacacccg   1080
 tatccgagat gcctgcctgc ggccgaccng tcatgcggcc cacaagtgta cgcagggccc   1140
 aaggggtcct ggatccccct gcccctctcc ccagcggttc aactccttgg gggagagaag   1200
 agagcagggc nagccttgtt gtttgtctgt ggccacaagc accaaggctt gacatgcaga   1260
 tgtaggggct ctgatggggg ctgttcccca acaggcctgg cagacgatta tatccctatc   1320
 tcagctgcgc tgagcagtct gggaacacag gaagtcaacc agctaaggac gagcttcctc   1380
 aaattggcag agctctttga acggctgagg aagctggagg gccgggtggc ttccgatgag   1440
 gacctgaagc tgtcagacat gctgaggtac tacatgcgtg actcacaggc agccaaggac   1500
 ctgctgtacc ggcggctgcg ggcactggcc gactacgaga atgccaacaa ggcgctggac   1560
 aaggcgcgca ccaggaaccg ggaggtgcgg cccgccgaga gccaccagca gctgtgctgc   1620
 caacgcttcg agcgcctctc cgactccgcc aagcaagagc tcatggactt caagtcccgc   1680
 cgggtctcct cttttcgaaa gaatctcatt gagctggcag agctggagct caaacacgcc   1740
 aaggccagca ccctgattct ccggaacacc cttgttgccc taaaggggga gccttagagt   1800
 agccagagct cagccaggcc ctaatctggg atctccagtg accagggtat cccagacccc   1860
 tctctccggc aagatgtctc cttccctagc agtgccacta gccacactgt att          1913



      <210> 1412
      <211> 605
      <212> DNA
      <213> Homo sapiens


      <400> 1412
 ggcgggaggc tgcttttttg cggggtgtgc gcccatgctg cggccggggg ctgttcctgt     60
 aaggcgggga gacaatgagt aaactctcct tccgagcgcg ggcgctggac gccgccaagc    120
 cgctgcctat ctaccgcggc aaggacatgc ctgatctcaa cgactgcgtc tccatcaacc    180
 gggccgtgcc ccagatgccc accgggatgg agaaggagga ggaatcggaa catcatttac    240
 agcgagcaat ttcagcacag caagtgttta gagaaaaaaa agagagtatg gtcattcctg    300
 ttcctgaggc agagagcaac gtcaactatt acaatcgctt gtacaaagga gagtttaaac    360
 agccaaaaca gttcattcat attcagctga aattgcatct taaattgctg ttgttcagga    420
 ttgaagtctt gttcttctaa agagaatttt catttgtttc tgccaggcat ttggggacac    480
 taccaaccgg agaccacgtt aaagtttttg cttgtttgtt ttggtcattt gtttttggac    540
 cacagtatta gctttaattt acgctgcaga tctgctcaag gttcagttct caggaagatt    600
 ttttg                                                                605



      <210> 1413
      <211> 792
      <212> DNA
      <213> Homo sapiens


      <400> 1413
 aggaaggctg attttattta gccgtttctt ttttcttggt ttgcacagta tctgggtcca     60
 gcctgcagcc ctagggtcca gttcagagtc tgtcatctga accatgagga tctggtggtt    120
 tctgcttgcc attgaaatct gcacagggaa cataaactca caggacacct gcaggcaagg    180
 gcaccctggc atccctggga accccggtca caatggtctg cctggaagag atggacgaga    240
 cggagcgaag ggtgacaaag gcgatgcagg agaaccagga cgtcctggca gcccggggaa    300
 ggatgggacg agtggagaga agggagaacg aggagcagat ggaaaagttg aagcaaaagg    360
 catcaaaggt gatcaaggct caatgaggat ccccaggaaa acatggcccc aaggggcttg    420
 cagggcccat gggagagaaa ggcctccgag gagagactgg gcctcagggg cagaagggga    480
 ataagggtga cgtgggtccc actggtcctg aggggccaag gggcaacatt gggcctttgg    540
 gcccaactgg tttaccgggc cccatgggcc ctattggaaa gcctggtccc aagggagaag    600
 ctggacccac ggggccccag ggtgagccag gagtccgggg aataagaggc tggaaaggag    660
 atcgaggaga gaaagggaaa atcggtgaga ctctagtctt gccaaaaagt gctttcactg    720
 tggggctcac ggtgctgagc aagtttcctt cttcagatgt gcccattaaa tttgataaga    780
 tccacatcac tg                                                        792



      <210> 1414
      <211> 555
      <212> DNA
      <213> Homo sapiens


      <400> 1414
 gccagcgccg ttgctgcggg ggattgtggg agtctccgcg tcccgctcgc tgggagagag     60
 agttgtctgc tggttctcag cttgaagaag attctgcagt ccttattgat cctttttctt    120
 ggcgttacca ttttttgaag caaagttaac ctagctttct agtttgagct ttctttttgg    180
 ccgtctttaa aaaaaatttt ttttttaatc tataaaatag acaagagcta gttctacaat    240
 gtccaagtca ttccagcagt catctctcag tagggactca cagggtcatg ggcgtgacct    300
 gtctgcggca ggaataggcc ttcttgctgc tgctacccag tctttaagta tgccagcatc    360
 tcttggaagg atgaaccagg gtactgcacg ccttgctagt ttaatgaatc ttggaatgag    420
 ttcttcattg aatcaacaag gagctcatag tgcactgtct tctgctagta cttcttccca    480
 taattgcagt ctatatttaa cattggaaga gaggtccact ccctttatct tctcaacacc    540
 gtggagatgc agacc                                                     555



      <210> 1415
      <211> 819
      <212> DNA
      <213> Homo sapiens


      <400> 1415
 ccgaatcatc ggataccgct ccggaatttc cgggtcgacg atctcgtccg agttggagta     60
 cgagtctgtg ctgtgtgtga agccagacgt cagcgtctac cggattccgc cccgggcctc    120
 caaccgcggt tacagggcct ctgactggaa attagaccag cctgattgga ctggtcgcct    180
 ccgaatcact tcaaaaggga agactgccta tatcaaactc gaggataaag tttcagggga    240
 gctctttgct caggcaccag tagaacaata tcctggtatt gctgtggaga cggtgacaga    300
 ttctagccgc tactttgtaa tccggatcca ggatggtact gggcgcagtg ctttcattgg    360
 cattggcttc acagatcggg gagatgcctt cgactttaat gtctccttgc aggatcactt    420
 caagtgggta aagcaggaat ctgagatttc caaggaatct caagaaatgg atgctcgtcc    480
 taagttggat ctgggcttca aggaaggaca aaccatcaag ttgtgtatcg ggaacattac    540
 aaacaagaaa ggaggtgctt ctaagcccag gactgcaagg ggtgggggtc tgagcttact    600
 cccacccccg ccaggaggca aagtcactat tcccccacca tcctcctcag ttgccatcag    660
 caatcatgtc accccaccac ccattccgaa atctaaccat ggaggcagtg atgcagatat    720
 ccttttagat ttggattctc ctgctcctgt cacgacacca gcaccactgt attgcggccg    780
 ctctggagga tccacgctaa cgtacgcggg cgttacact                           819



      <210> 1416
      <211> 812
      <212> DNA
      <213> Homo sapiens


      <400> 1416
 gcgctgcagg caccgggccg gaattaccgg gtcgacgatt tcgtgcgggg cccgccgagg     60
 cccggcttct gtcctgcgcg cgcagattct cgcaaatctg gaagcggatc gcgtggagtg    120
 acggtcacac cgcggcgaat taattcccaa agactcatgt tacatgagaa agccaccaag    180
 aagaccaaag aaaaggagac aaggatggct cttcctcagg gatgcttgac tttcaaggat    240
 gtggctatag aattctcttt ggaggagtgg aaatgcctga accctgcaca gagggcttta    300
 tacagggccg tgatgttgga gaactacagg aacctggagt ctgtgggatt gacttctaag    360
 gactcttggt acatgaggaa gaaacccgga aggggaagag gaaagcaaag gcgtcaggaa    420
 tggttcttcc tcagggtcta ttgacattca gggatgtggc catagaattc tctcaggagg    480
 agtggaaatg cctggaccct gctcagagga ctctatacag agatgtgatg ttggagaatt    540
 ataggaacct ggtctccctg ggtgaggata acttccctcc agaagtgggg atgttccctt    600
 gtgtatcttt gcattttctc ttgtttctct tgggagttgc atccttgctt gactaaaatg    660
 gaagccgtat tgattttgaa atgaaaagct tcatgatgta gcatctggac tttcactgtc    720
 ccctttttta gatgttctgc gctcttcatg atagctcagt gggggttcca gaagtaaaga    780
 ttgctctata ccttatggct ggcaaggcgt gg                                  812



      <210> 1417
      <211> 403
      <212> DNA
      <213> Homo sapiens


      <400> 1417
 cattgtcctg gcagagcggc gagccggtga gtgtggctgc ggggtcgcgc ccaccctcta     60
 cctgtgccgg gggccggaac ctggccccgg ggagggcgcg gcctcgggga gacggcgtgc    120
 aggcccagca ctgttggtca ccgcaggcct gtcttcctat tcaccgtggg cagcagaggg    180
 atggctgctc agctgctgac tgatgaggca ctggaatcag tgacgttcag ggatgtgact    240
 gtggacttca cccaggagga gtggcagcag ctggagcctg cccagaagga cctgtacagg    300
 gatgtcatgc tggagaacta caggaacctg gtctcactgg cttttctgga ggtattattg    360
 acctgtaatt aaccacgcat atataaagtg aagagtttga tgc                      403



      <210> 1418
      <211> 1134
      <212> DNA
      <213> Homo sapiens


      <400> 1418
 gcggccgcct cggtacggca gagcccgggg ccggcgctgg cgcggctgga gggccgagag     60
 ttcgagttcc tcatgcgcca gcccagcgtc accatcggcc gcaactcgtc gcagggctcg    120
 gtggacttga gcatgggcct gtccagcttc atctcgcggc gccacctgca gctcagcttc    180
 caggagccgc acttctacct gcgctgcctc ggcaagaacg gcgtcttcgt ggacggggcc    240
 ttccagagac gcggcgcgcc cgccctgcag ctgcccaagc agtgtacctt ccggtttccc    300
 agcacggcca tcaagatcca gttcacttcg ctctatcaca aagaagaggc cccagcctcc    360
 ccgctgcggc cactgtaccc ccagatctcc cctctgaaga tccacatccc ggagccggac    420
 ctccggagca tggtcagccc cgtcccctcc ccgacgggca ccatcagtgt ccccaactcc    480
 tgcccagcca gtccacgcgg tgccggctcc tccagttacc gctttgtgca gaacgtgacc    540
 tcggacctgc agctggcagc agagtttgca gcaaaggccg cgtcggagca gcaggcagac    600
 acgtctggag gagacagccc caaggatgag tcaaagccgc cgttctccta cgcgcagctg    660
 atcgtgcagg ccatctcctc cgcccaggac cggcagctga ccctgagcgg gatctacgcc    720
 cacatcacca agcattaccc ctactaccgg acggccgaca aaggctggca gaattctatc    780
 cggcacaacc tctctttgaa ccgttacttt atcaaagtcc cacgttccca ggaggagcct    840
 gggaaggggt ccttttggcg aatagaccct gcctctgaag ccaagctcgt ggaacaggca    900
 ttccggaaac ggaggcagag gggtgtctcc tgcttccgca cccccttcgg gcctctgtcc    960
 tcaaggagcg ctccagcttc gcccacacac cccgggctga tgtcccctcg ctccggcggc   1020
 ctgcagaccc cagagtgcct gtctcgggag ggctccccca ttccacacga ccctgagttt   1080
 gggtccaagt tagcttctgt cccagagtac cggtattccc aacccacgcg tccg         1134



      <210> 1419
      <211> 1127
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1127)
      <223> n = a,t,c or g


      <400> 1419
 agagaatcca cactggagag aaaccttaca aatgtaatga gtgtggcaag gtcttcagtc     60
 acaagtcatc cctagtaaat cactggagaa ttcatactgg agagaaacct tacaaatgta    120
 atgagtgtgg caaggtcttc agtcacaagt catccctagt aaatcactgg agaatccaca    180
 ctggagagaa accttacaaa tgtaatgaat gtggcaaggt cttcagtcgc aattcatacc    240
 ttgcccaaca tctgataatt catgccggtg agaaacctta taagtgtgat gaatgtgaca    300
 aagcattcag tcaaaattca catcttgtac aacatcacag aatccatact ggagagaaac    360
 cttacaaatg tgatgaatgt ggcaaagtct tcagtcaaaa ttcatacctt gcatatcatt    420
 ggagaattca tactggagaa aaagcttata aatgtaatga atgtgggaag gtcttcggtc    480
 taaactcatc cctagcacat catcggaaaa ttcacactgg agagaaacct ttcaaatgta    540
 atgaatgtgg caaagctttt agtatgcgtt caagcctcac taatcatcat gcgatccaca    600
 ctggagagaa acatttcaaa tgtaatgaat gtggcaaact cttccgcgac aattcatatc    660
 ttgtacgtca tcagagattt catgccggaa agaaatctaa cacatgtaat taatgtggca    720
 gagtgttcag ttagcattaa agccttgtaa gacatacaat aatttatact ggagaaaaac    780
 tttgcaagta taatgaatgt agcagagcct ttagtttttg ttcaaggctt aataaccgtt    840
 agctagacca tagaggacag aaactttact aatgtactga atgtggcaag gtcttaaggt    900
 aaaatctgag accaggattt ttcaaagaat tccttgctgg tgagaaacct aacaaatgta    960
 atgaatgtgg caaggtcttc agtcgcaatt cataccttgc ccaacatctg ataattcatg   1020
 ccggtgagaa accttataag tgtgatgaat gtgacaaagc attcagtcaa aattcacatc   1080
 ttgtacaaca tcacagaatc catactggng agaaacctta caaatgt                 1127



      <210> 1420
      <211> 1049
      <212> DNA
      <213> Homo sapiens


      <400> 1420
 ggaaggcctg gtgcaggagc ctctgagctc tttccttctg tgaccacgga cctgtcagtt     60
 tccaaacaaa acgcgtgcct cacttgtgtg gattttgtca ctgtgcatgt atgtatgggt    120
 ttctggggca ttggtcctgg tgctctctcc acatcctgca tcccgtaccc tctgtctcat    180
 ggcccaggca gtgtgaaggc ggagatgctg cacatgtaca gccagaagga cccgctcatc    240
 ctctgtgtgc gcctggccgt gctgctcgcg gtgaccctca ctgtgccagt cgtgctgttc    300
 cctatccgcc gggccctgca gcagctgctt ttcccaggca aggccttcag ctggccacga    360
 catgtggcca tagctctgat cctgcttgtt ttggtcaatg tccttgtcat ctgtgtgcca    420
 accatccggg atatctttgg agttatcggg tccacctcag cccccagcct catcttcatc    480
 ctccccagca tcttctacct ccgcattgta ccctctgagg tggagccttt cttatcctgg    540
 cccaagatcc aggccctgtg ctttggagtc ctgggagtcc tcttcatggc cgtcagtcta    600
 ggctttatgt ttgccaactg ggccacaggc cagagccgca tgtctggaca ctgatcaggc    660
 cctgctggcc caggtccctg tgcgcatgca catggagggg tcagggccgc tccctagggt    720
 ccctcctgcc caacatgtgg aggtggctgg ttcccatgaa cgtggttgtc agaggcgggg    780
 gacagcagag gctgcagact ggcccacttc cctcctcccc agggatgcca agcttggatc    840
 atggccctaa tcccaacccc aaccccatgg gaggaggagg aggaggaaga agaggaggag    900
 gaggaggagg aggaggagga ggaggaggag gccaggtcct ggtggagcct ttgcccagcc    960
 cagtcctctc tgcctcctcc tggctgaagc tgtttgtcca ggattaccct cggggctaaa   1020
 gaggaaaaat aaagatgttg agctaccaa                                     1049



      <210> 1421
      <211> 6191
      <212> DNA
      <213> Homo sapiens


      <400> 1421
 tttttttttt ttaagaaaca atatatttta tttttctgac accacagctc tggcgagtgg     60
 ttttgtacca aatttaatgg aggttacaca gaacgtctta cgcatgggag ggggaggaaa    120
 gggaaggaac cacaaaattt aaaacaaaca gaaaccaaat tcctggatag cttttagcat    180
 ctgtcccact cccacattaa taaaattcac ttgggaattc ctaataaaag gaaaacaaaa    240
 aacaaggtgg ggcagggaag ggtatgatgg gaaaggagaa agacttaggg ggaaaaaaga    300
 ccagagagca tcccaaggac agacctttcc ctctcagagc caagaggacg ctcggcatgg    360
 aaggcgaggc tttgctagat ttatttcccc aaaataacac tgtgtattgc agctgccaaa    420
 gggaaagaga gagggaagca gagggtcacc agcggggggc acaaaggaag gaaacactta    480
 actgaggaga cagagcaaaa tcggagagag aaacagagaa aatgtgccag tgggttggta    540
 tattgggaga caagacagtg ctgaagagca cttgaactga aaaacaaatg tcctaagagt    600
 cattattttt caaaagaaaa atctcccccc tccccccacc cctcgctgaa cttagttcct    660
 ttttttgtgc ttttcattaa tactctgctc tgaggtcgta gtttggtttt tctatacact    720
 gcagttgaaa gaaaatagtc caaaggtctg aagatggatt ctccacctaa agtaaacagc    780
 ccagcattcc tgttctcctc ttgccccaaa gactaaagtc tctgctaaaa tcccttttac    840
 aatatagtac agtacacaga aaaaaataaa gcccaaatca aaaaaacaaa aacagaaaag    900
 aatcctggga gaagccagtc caaaggacgt aaacatacag agaacggtgc aacacatgac    960
 cgatggcaat tctcaaagca cagctacaga ttcccaaaag taggtgccat cattgatacc   1020
 caagtccaca aaaataattt ttaaaaaata aatcttaaaa aaaacacacc tgttgattaa   1080
 atgaataatt tgttttcagg taaatccata cattctcgag ttcccccctc ccccaaagca   1140
 gccctcgggt ctctgttctc ctattgcatg accaatagta agtactcctg gaactccctc   1200
 aaagcagctc tcaggacctg gaatctcatc ttgacaagga tcggcacatc ccatcttagc   1260
 agcttaaaac atcatgtttc ctgggttgcc aggtccttgg ctaaatccac ccatgcccac   1320
 gtcagcagcc atgccccggg gcctcatctg tggggggatc atgatgttct gttggggtcc   1380
 catcatgccc tgcatggaca tcatcatgcc tggagagccc acaggcccag ggtgggtgta   1440
 gagcccggca ggcccccgat ccttgccagg aatcatgccc acggcagcag ctggattgct   1500
 catcagggtg ggctggccgg gcattgtaga ttgtgctggt gacatcatcc gatggtgagg   1560
 tcccatcatg ccttgttgga gaaaggctgg tggtctcatg gggttgtggc ctggcatgga   1620
 tggagctgta ccaagaggga tgtccggagt tcccactggc cctggacctc ccatgccagg   1680
 taatgctagt cccattctgg gggcttgttc gcccatcatc ccctgcatgt gtgaaaaccc   1740
 aggtccagga ccctggggct gtttacggcc tggaacttcc cctcgaggga aatattgcag   1800
 cgtctggctg ggcttctcag atggaataat gcgggataga tcaaactcag gtattccggt   1860
 ggctccaggt cggatgacct cctgcagatc tgggtctgta aacaccgaag gcatgctgtt   1920
 ccccaggaca gtgaaggagt caggaccccc ggggcctcca ggcttgcaaa gtgctgcatc   1980
 tgctgaactt tggggcaggt tgctggggcg gccaaggggg ccttctcctg ggaaacccat   2040
 ccctcctggg aagctgccct gccccccact ggggccattg tgagggaatg gaacctgctg   2100
 tgggggagac tgtactggag ggaagccctg ggggaagccc atccgtcctt gaggtaccat   2160
 cggtggctct tgggacccat gccccatgat aggattgtgt gacatcaagc caggccccat   2220
 tgggacccca tgaggaggta tgttgggtcc cacggcattt ggagagggca tctgattgga   2280
 gtgagaaagt ggctgggtca ttcccattgg gctgagggtt ggcatcggaa ccacggggtt   2340
 tggacctgaa attcgaggat tctgtgtatt aatgcccatt cctggcatat tattcattga   2400
 tggcaagttg ggagaacgag ctggagggga gtcgtcatct gagctggcca cagtcttgat   2460
 agcatcatgg ttataaccgg ggttggaaac tgggccattg caaacttgga cattccgaga   2520
 catccataat agagagtggg ttctgggaaa gggttggctc tggaggcatg gtataaggtg   2580
 tactagaggg aagacttccc agggatattc acagaggcag gctggctggc tgtaggaggt   2640
 ggggggccac ctgactctac atttcccagc atggctgggg aggccatggt gaggggtgct   2700
 ttatggtttg gagggatccc aggactctga aggggaggct ctggagaaga ggtccatcca   2760
 ggtgacgggg caggaagtga tggagacttg aggtggacag gtgaagcagc agcagacccc   2820
 aaaacagggg gggacttaat ggaagcagca gcagctgggc ccgccagcat gcctgccagc   2880
 tgcgatggag tctgggggga cttgaggttc cccgagggcg agcccagcat tggtgactgg   2940
 acttggtgca tcgtgggaga cttcagaggg ttaatgcctg gggaatgcac ctggctgcct   3000
 gccacagata tatccaaggg cttccgcccc aggccgcgct gaactggagg agctgtgttg   3060
 aggctggtgg ggttactgga agggttgaga ggtagtggtg gcatatgact gagccggctg   3120
 ttagtcctct ggtcgggccc aattggttct ctgagattcc gcaagccact gttgctgcct   3180
 ggaccctgag acatgggaag gaatggtctg gggcccatgc catactcctg ctgggggtgc   3240
 tcaccaaatg gcagtggcac catcttctgc tgagcaggca gcatgtctga gccacctggg   3300
 cgtaatttca gcatctcctc agggcccgcc ccagcctctc tcatcttctg aggtatcatc   3360
 tgagagttgg atcccatgtt gacatttaga ttgacatctc ccttcatccc actaggaacc   3420
 atcccaaact caagttcccg accagggccc atctgtgggg gaattccttt tggaaagtca   3480
 cccctagaag gactcagagg gccctcaact ggtattcgag ggaaaatggg gttattccca   3540
 ggctccatgt ggcgctggga gcctggaatc atcctgttca tctccatgct gggcctgatg   3600
 ccttccatgg ccatccctgg ggggagaccc agctgtttct ctgccagctg ctgctgaaac   3660
 atctcttcag acaatccttg ggggtttggg aagcgttccc ctcggccagg accgctgaaa   3720
 atgccctggc caggaggaaa atttcgacca tctgggattt ttggcacatc atctggccaa   3780
 ctgactccag aaagacctgg tctagatgca gggttgggga cattcggccc ttccatttca   3840
 gagtttatca tgcctgcaaa tccagggagg cgcatctggc tccctggcat gttggggtgg   3900
 ggagccatgc ccctcggggg cagagaatgt ggcatgttga taccatcaga aaatggctct   3960
 gtacccccag gtgcccagcc ttcactaggg gtcatctggt atggaggggg gggtcctcgg   4020
 accactcccc gaggcccgtg ctgatggacc atcatgtcct ggagggaaca ctgctggaca   4080
 accacttgtt ccggcttcct cctcttctct tcataaaact cctgctgcag tttcagccac   4140
 gctatctgct cgggagtcat atggtcaagg tggtcgggtc ctatggtccc agactgggag   4200
 ttcatagaag gtggaaccat ttcatctgga gaaaagggta catctctatg tccttgaggg   4260
 ccaaatggag ctcccacgtc tgtccggggc ccaggtccct tacctaggct ttgggattgg   4320
 gccatcatgg cctgtattgg cccttctggt tttttctgag gcccatctaa taccccagga   4380
 ttctgctgcg gtcccccact ttgtgctcct gtgaattctt tctcatcagg aaaaagcatg   4440
 cgctggatat ctctgagagt ttgtaaggag cgctcccggt gctccagctg ctcctgagat   4500
 aggccatcgg gattctctcc cagtgtgggg ggctcgccac tggacactgg tggaggcgga   4560
 ggggctttgg gatctgctga agagctattg ctcccctggg agacaggggt cactgcccta   4620
 ttgttgggag ttgagttggg cccagtacca tctgggggca gtggagtgga gctggcagga   4680
 cttcctacag aaggaatcag tttgttttct accccaggac tctcccggtc caggggacgt   4740
 gggggtgcgg caggcttggg tgctggtgcc ggaatgggtg gagttggctg cagtctggta   4800
 ttctgggaag aattctggtc ctggttggcc ggagctgggg gctgttgtgg gagaggtttc   4860
 ggatcattcc gaagggcaga tatctgtgtg ttcagaggcg ctgtgcttct ctctgtcttg   4920
 ttgttagaaa tgttctggat gtggaaagag acgatagttt caacctggcc cttcaaaaca   4980
 gcttctgcag ctttattggc catctcagta gaaaacacgt acaccacttt ggctggagtc   5040
 ttctgagcag gtgtgggctc tgtggcagta gtttggccat gggggggggt agaagacctg   5100
 ggggctgtag catttgatgg ggtcatcgag tgtggtgtgt gctgggaatc ctgggacttt   5160
 atgtggtcag cagaattaca ttctttaatg tcagagtcat cgtttggagt cccaggatct   5220
 ctctgatcaa aggagtcggc ggaaatactt cgctcccttt tccccttgcc cttggcacca   5280
 tttccagccc cattcttcag ccccatgctc ccacctgggc cagggagtgc tttaggggta   5340
 tggcccccac tcttggagtc acagggggat ggctgggatt ggctggctga gcccccctgt   5400
 ttaccctgat tggagaattt ggaatccagc tgggggtttc cagatgggga catcactgta   5460
 gggggacgga ccatcacctc ctgctttgac ttagggctac tctgtgtgtt tcctgatgga   5520
 gagctcctca ctttagggtt actggaatgc attgattgaa atcctgagct tgcagtcaca   5580
 aacgggacag gctcaccgag ttcctctcgg gttgcagcag aaacagctgc tgggggcagt   5640
 ggcactggcc cactgcttgc tgggtgcgtc ccttagcgct cgctgcctgt atgccttttt   5700
 cctctttgtt tttctctgct gtggaagtgg gtcctttccc cttgcagctc cagcattctc   5760
 tgggtgcgtg cctcctgctg ccagaggaaa atctcgcatc tccagggcat acaaaacccc   5820
 aagggtcacg acactgcagt gctcatcctg gaggtgagga gtccaggaac ccccttctca   5880
 aagatgaccc ttgtctttca atatgtccaa tttgctattt cttctacatc gggacacgga   5940
 agaactttcc aaaaatgatc tctgccaccc aatcagatgg gaatgtttag gtcaaagcag   6000
 aatgacgcca actgggccca cattcagtcc ttttttatga ggagaaattc tggagaatca   6060
 tttcagaaac tgagggggga aagtgaatga agacaaaaaa gacccttttc ccgcaatccc   6120
 tggcctcctg gtatcaagac accaggacaa catcaaagca acttaggggg aacactttag   6180
 gggccacgaa a                                                        6191



      <210> 1422
      <211> 2108
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2108)
      <223> n = a,t,c or g


      <400> 1422
 gactaccatg ataaaagaat tttcaaggaa ctgaaatcca gtgacaaaaa tgaaatcgat     60
 caaggctgta gttgcacacc tgagacattc ctcgagaagg cagaggagaa aggtgtgaaa    120
 aacagtgaac cagagaagga tggccaggga caacaaagat tggagctcgg aagttgaatg    180
 acagatattc tggagaaaca caccagagat gacaaaaggg tttgtcaaac acagcccaac    240
 tcaactggag tcctgagaag gtgaccagac caggatggag gcccagggaa ctcaccagaa    300
 gtccccatgc atcagaacaa ggtcgaagca tcctgacgga gtctcgctct ttcgcaaggc    360
 tggagtgcaa tggcatgatc tcggctcact gcagcctccg cctcctgggt tcaagtgatt    420
 cttctgcctc agcctcccga gtagctggga ctacagaaat gctggtaatt tcagtcactt    480
 gctgatgact tctgatgtcc cagcaaatgt tggcattgtt gactgctgag aagatacttc    540
 tgaggaccca cgtctaaggt ggacttggtt cgcactcttc tggttagtcc ctgaacagga    600
 gtgatgcctc caggcaggtg gcatgctgcc tatccagctc aggcccagtc ttcgagggag    660
 cgagggcggc ttcagacagt aaagaaggaa gaagaggatg aaagctatac tccagtgcag    720
 gctgccaggc cacagactct caaccgccct ggccaggagc tgttccgcca gctcttcaga    780
 cagcttcgct accatgagtc ttcagggccc ctagaaactc tgagccggct ccgggaactc    840
 tgtcgctggt ggctgaggcc tgacgttctc tccaaggcac agatcctaga gctgctggtg    900
 ctggaacagt tcctgagcat cctgcctggg gagctccggg tttgggtgca gcttcataac    960
 cctgagagtg gcgaggaggc tgtggccttg ctggaggagc tgcagaggga ccttgatggg   1020
 acatcctgga gggacccggg ccctgcccag agcccagatg tgcattggat gggtacagga   1080
 gccctgcgat ctgcacagat atggtccctt gcttcacctc tcaggagcag ctctgctctg   1140
 ggggaccacc tggagcctcc ctatgaaata gaagcacgtg acttcctggc tgggcaatcc   1200
 gatactcctg ctgcccagat gcctgccctt ttcccgagag aggggtgccc gggagaccag   1260
 gtaacaccaa ccaggtccct gacagcccag ctccaggaga ccatgacttt caaggatgtg   1320
 gaggtgacct tctcccagga cgagtggggg tggctggact ctgctcagag gaacctgtac   1380
 agggatgtga tgctggagaa ttataggaac atggcttccc tgggtaagta atcgatatcc   1440
 tcatgcttct atccatcttt atttctgcct tcttgggttg ttctgtgctg catagaaagg   1500
 tacctgacct ggttttagat cctggctctg taactgctga ccagatcact taatctagca   1560
 ccttggtagc ctcttttgaa aaatggggag aataatgcct gccattctgg attattgtaa   1620
 agattaaagg tggcggggcg tggtggctca cgcctgtaat cccagcactt tgggaggccg   1680
 aggcaggtgg atcatgaggt caggagttcg agaccagcct ggccaacatg gtgaaacccc   1740
 atctctacta aaaatacaaa aattagccgg gtgtggtggc gggtgcctgt agtcccagct   1800
 actcgggagg ctgaggcaga agaatcactt gaacctggga ggcggaggtt gcagtgagct   1860
 gagatcatgc cattgcactc cagcctggcg acagagcgag actcattctt cttttatact   1920
 tttgaggtta tgtacgtctt tcattctctt tcgccttact ccgggcacgg cctcccggcc   1980
 tcggcctcac tcagctcagg caccgcaggc accgtttggc cgcgggctcc gtaaagctgg   2040
 aacccttcag agccggagcg ccgccacgaa atcgtcgacc caggatgtnn naancggtac   2100
 cgcaggtg                                                            2108



      <210> 1423
      <211> 780
      <212> DNA
      <213> Homo sapiens


      <400> 1423
 ggaattccac gctgcttttt ctctttccta aatgcagcgc ttgcttgggg acttcaaggg     60
 aaggcttttg gttggtgggc tgagtgaccc caggctccga gaggggcagg cattgcttgg    120
 gaggaggtgg gagatgcacg catgccctta gctaggcgtg gggtggctca gttaagaagg    180
 gcactgcctc cgcagcccct cggcgctcag ccagctgcag ccccaaaggt ctagggcttt    240
 agggaaccga tccaggtttg ggggcgggga gaaagttctg aggcagctcc tccctggaca    300
 gagcagggcg accccgcgcc gggcctgcag gctcctacag ctactgcccg ccagcgggca    360
 aggcgaaggg ccctaccagc cagctgagcg ggggattgtg ctgtaggccc tccagcagct    420
 gctctaaccc ctgccaagcc tggtgcacac cctcgcggct ctgcaccagc cgctctgcgg    480
 gcagctcctc tacagagcca gctgaggcca cgatgccata gagctcacag aggctgtgcc    540
 gcgcccgccc cactggctgc tggagctcgg cgggcaggcc ctggaggctg gagaccaggc    600
 cactgtaggc cgtgtgcagc tgccggagaa ggccgcagac cctggacaga accccggcat    660
 cccgctcctg tgggaggaag gcgcaaggtg agtggagacc catgggcggg gtggggggac    720
 cctagccctg tgccagaccc atctcctgga cagcagcgtc ctccgcactg gcacctgagg    780



      <210> 1424
      <211> 832
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(832)
      <223> n = a,t,c or g


      <400> 1424
 ggcacgagag actgcatagg gctcggcgtg gtgactcaca cctgtaatcc cagcactttg     60
 ggaggccaag gcgggcagat cacaaactca ggagatcgag accatcctgt ctaacatggt    120
 gaaaccccgt ctctactaaa aatacaaaaa attagctgcg catggtggca ggtgcctgta    180
 gtcccagcca ctcaggaggc tgagacaaca gatgcacgcc accacacccg gctaattttt    240
 acagggtcct gctacgcacc attttatgtc cctacctaca gtgcacaagg gttaaaatgg    300
 ctccccaaaa aggatactgc ctttgaccat ccctggctca cactcataat cccactcaat    360
 tttactaact tggtggtaaa gttgagccac gtacacggcc gaggggattg tgactgtcgt    420
 gtcctcgtcg acctccttct cctgtcgctc cagatccgcc tcaatctcct tgagctcttc    480
 cagctctctg gtgagctgaa ggaggctggc cttcagacgg gtgtcctcct ccccagcctc    540
 ctgaagccca gcttccagct gctgcagctc cacgcctccc tggtgcacct gctccttcgc    600
 attgagaagg ctctgggcca cttccttctc catggtgagg atctctcgca gctgcttctc    660
 ggcaccgtct tgcgtttcca gcagccgctc caccacctgc tcgtggcgcc ccagcagccg    720
 tcgctgctgc gcctccgcgc ggttggcgcc cagcaggctg agcagcccct ggctcacctc    780
 ctctatgtcg cggaaggcga attccncggc ntgtcctagg nanccagtcc ag            832



      <210> 1425
      <211> 1245
      <212> DNA
      <213> Homo sapiens


      <400> 1425
 tggaagaagg gagtgagact gctcagagag gcaggattcc tgctgactcc agggggacac     60
 ctggcacctc agcttccttt cccacttctc caggctgcat ggaggggtgc cgggcagggg    120
 cctcctggaa gggaacctcc tgcagcctca agcaccaggt catgacatga catctatccc    180
 tttcccaggt gaccgactcc tgcaggtgga tggagtgatt ctgtgcggcc tcacccacaa    240
 gcaggctgtg cagtgcctga agggtcctgg gcaggttgca agactggtct tagagagaag    300
 agtccccagg agtacacagc agtgtccttc tgctaatgac agcatgggag atgaacgcac    360
 ggctgtttcc ttggtaacag ccttgcctgg caggccttcg agctgtgtct cggtgacaga    420
 tggtcctaag ttttgaagtt caaactaaaa aagaattgcc aatggtttgg gattcagttt    480
 cgtgcagatg gagaaagaga gctgcagcca tctcaaaagt gatcttgtga ggattaagag    540
 gctctttccg gggcatccag ctgaggagaa tggggccatt gcagctggtg acattatcct    600
 gggccgtgaa tgggaaggtc cacggaaagc ctcatcttcc aggtgccggg ggtcatgggc    660
 aatgcagctc tctgtgcagg ctggccccag ctttgcctct tactatcctg ctgccgtgga    720
 ggtgctgcat ttactgagag gggccccaca ggaagtcacg ctcctccttt gccgaccccc    780
 tccaggtgcg ctgcctgagc tggagcagga atggcagaca cctgaactct cagctgacaa    840
 agaattcacc agggcaacat gtactgactc atgtaccagc cccatcctgg gatcaagagg    900
 acagctggga gggacagtgc ctccccagat gcaggggaag gcctggggtc tcaggccaga    960
 gtcttcccaa aaggccatca gagagggcac aatgggggcc aaaacagaga gagaccttgg   1020
 gccagttcct tgacacattc tcctgagtcc caccctcatt tatgcaaact tcaccaagaa   1080
 agggatgaat caacattggc gacctctttg gaaaaggatg tgaggcaaaa ctgctattca   1140
 gtttgtgata tcatgagact tggaagatat tccttctcat ctcctctaac cagactttcg   1200
 acagatattt tctgagcacc ttctctgcat gtctgcagtg ctgtg                   1245



      <210> 1426
      <211> 460
      <212> DNA
      <213> Homo sapiens


      <400> 1426
 cgaggatttc gtcgcccagg atggcggcgt caagtggggc aatttttggt tgaggttttg     60
 gagagcaagg tggcagccgg gagcccatca gaggaaaagt gggaggcgct ggaaccctgc    120
 gtccaggcgt gacggtcatc ccgaaaggcc ggccccagtt tcatcctttt atcctgtaat    180
 ctgtcaccat gaccctgaca aaaggttcct tcacctactc cagtggggag gaatatcgtg    240
 gcgagtggaa ggagggccgc aggcatggtt ttggtcaact gatgtttgca gatggtggca    300
 cctacctggg tcattttgag aatgggctct ttaatggctt tggggtattg accttctcag    360
 atggttcaag ggtatgaagg gggagtttgc ccagggcaag ttttaatggg ccgtcggagt    420
 ccttccattt cgatatgaca acactgacct tgagggggag                          460



      <210> 1427
      <211> 2307
      <212> DNA
      <213> Homo sapiens


      <400> 1427
 gacccacgcg tccgcgcagt ttgctctcct tgttttgctt tcgagctgga ctgttctcag     60
 gcaagccggg gagtaacttt tagttttgct cctgcgatta ttcaactgac gggctttcat    120
 ttccatttca cacaccctag caacacttat accttgcgga attgtattgg tagcgtgaaa    180
 aaagcacact gagagggcac catgccggtg gaaaggatgc gcatgcgccc gtggctggag    240
 gagcagataa actccaacac gatcccgggg ctcaagtggc ttaacaagga aaagaagatt    300
 tttcagatcc cctggatgca tgcggctaga catgggtggg atgtggaaaa agatgcacca    360
 ctctttagaa actgggcaat ccatacagga aagcatcaac caggagtaga taaacctgat    420
 cccaaaacat ggaaggcgaa tttcagatgc gccatgaatt ccttgcctga tattgaagaa    480
 gtcaaggata aaagcataaa gaaaggaaat aatgccttca gggtctaccg aatgctgccc    540
 ctatcaaaac ggccttctaa gaaaggaaag aaaccaaaga cagaaaaaga agacaaagtt    600
 aagcacatca agcaagaacc agttgagtca tctctggggc ttagtaatgg agtaagtgat    660
 ctttctcctg agtatgcggt cctgacttca actataaaaa atgaagtgga tagtacggtg    720
 aacatcatag ttgtaggaca gtcccatctg gacagcaaca ttgagaatca agagattgtc    780
 accaatccgc cagacatttg ccaagttgta gaggtgacca ctgagagcga cgagcagccg    840
 gtcagcatga gcgagctcta ccctctgcag atctcccccg tgtcttccta tgcagaaagc    900
 gaaacgactg atagtgtgcc cagcgatgaa gagagtgccg agggacggcc acactggcgg    960
 aagaggaata ttgaaggcaa acagtacctc agcaacatgg ggactcgagg ctcctacctg   1020
 ctgcccggca tggcgtcctt cgtcacttcc aacaaaccgg acctccaggt caccatcaaa   1080
 gaggagagca atccggtgcc ttacaacagc tcctggcccc cttttcaaga cctccccctt   1140
 tcttcctcca tgaccccagc atccagcagc agtcggccag accgggagac ccgggccagc   1200
 gtcatcaaga aaacatcgga tatcacccag gcccgcgtca agagctgtta agcctctgac   1260
 tctccgcggt ggttgttggg gcttcttggc tttgttttgt tgtttgtttg tattttattt   1320
 ttttctctct gacacctatt ttagacaaat ctaagggaaa aagccttgac aatagaacat   1380
 tgattgctgt gtccaactcc agtactggag cttctcttta actcaggact ccagcccatt   1440
 ggtagacgtg tgtttctaga gcctgctgga tctcccaggg ctactcactc aagttcaagg   1500
 accaacaagg gcagtggagg tgctgcattg cctgcggtca aggccagcaa ggtggagtgg   1560
 atgcctcaga acggacgaga taatgtgaac tagctggaat tttttattct tgtgaatatg   1620
 tacataggca gcactagcga cattgcagtc tgcttctgca ccttatctta aagcacttac   1680
 agataggcct tcttgtgatc ttgctctatc tcacagcaca ctcagcaccc ccttctctgc   1740
 ccattcccca gcctctcttc ctatccccat cccatcccat cccatcccat cccatcccat   1800
 cccgctcttt tcctactttt ccttccctca aagcttccat tccacatccg gaggagaaga   1860
 aggaaatgaa tttctctaca gatgtcccat tttcagactg ctttaaaaaa aatccttcta   1920
 atctgctatg cttgaatgcc acgcggtaca aaggaaaaag tatcatggaa atattatgca   1980
 aattcccaga tttgaagaca aaaatactct aattctaacc agagcaagct tttttatttt   2040
 ttatacaggg gaatatttta ttcaaggtaa aattctaaat aaaatataat tgttttttat   2100
 cttttctaca gcaaatttat aattttaaga ttccttttct tgtttatcag cagttgttat   2160
 tacatccttg tggcacattt ttttttttaa ttttgtaaag gtgaaaaaag cttttatgag   2220
 ctcatgtagc aatcagattt tcctgtggat tgataataaa tgaatatgat atatagttaa   2280
 atttttaagg ggcatcaaaa aaaaaaa                                       2307



      <210> 1428
      <211> 1431
      <212> DNA
      <213> Homo sapiens


      <400> 1428
 ttacaatttg gcatgttttt gcagtggctt gtactggttt ttcctttcca tgtttagtgc     60
 ttccttcagg agctctggta gggcaggtct ggtggtgaca aaatctctca gcatttgctt    120
 gtctgtaaag gattttattt ctccttcact tatgaagctc agtttggctg gatatgaaat    180
 tctgggttga aaattctttt ctttaagaat gttgaatatt ggcccccact ctcttctggc    240
 ttgtacagtt tctgctgaaa gatctgctgt tagtctgatg ggcttccctt tgtgagtaac    300
 ccgacctttc tctctggctg cccttaacat tttttccttc atttcaactt tggtgaatct    360
 gacaattgtg tatcttggag ttgctgttct cgaggagcat ctttgtggcg ttctctgtat    420
 ttcctgaatt tgaatgttgg cctgccttgc tagattgggg aagttctcct ggataatatc    480
 ctgcagagtg ttttccaact tggttccatt ctccccgtca ctttcaggta taccaatcag    540
 acgtagattt ggtcttttca catagtccca tatttgttgg aggctttgtt catttctttt    600
 tattcttttt tctctaaact tttcttcttg cttcatttca ttcatttgat cttccatcgc    660
 tgatacactt tcttccaatt gatcgcatcg gctactgagg cttgtgcctt cgtcatgcag    720
 ctctcgtgcc atggttttca gctccatcag gtcctttaag tacttttgtg cattggttat    780
 tctagttagc cattcgtctt tggtctttga tgaaggtgac atacagatgg gtttttggtg    840
 tggatgccct ttctgtttgt tagttttcct tctaacagtc aggaccgtca gctgcaggtc    900
 tgttggagat tgctggaggt ccactccaga ccctgttttc ctgggtatca gcagcggtgg    960
 ctgcagaaca acagatattg gtgaaccgca aatgctgctg cctgatcgtt cctctggaag   1020
 ttttgtctca gaggagtacc catcaacatg tgggtgagtg gttatgtctt ctaggccgta   1080
 agtttccagc agggatggaa gcgtgcacag ccatgttgtg ctcgtcttct gttctggaag   1140
 cagcaacgct ttcattctca gtccagcata gggcctgcac tggtgggagc taaaagccgc   1200
 agcagggaag ggtctatccc tctgagggtc gggaacataa cggggctgca gcgttcggtc   1260
 ccttttgctc ttctgagtgc cctgcttctt gtcctgaccc tggaacccaa ccctgtgctc   1320
 ctggaactta cataccattc ttttcctgtc aaacgtgagc cttctgtgac tcccagaaac   1380
 agtagcatcc atgtacctgg agagcagcag ccccaggtgg catcttccca t            1431



      <210> 1429
      <211> 660
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(660)
      <223> n = a,t,c or g


      <400> 1429
 ggatcagagt atggaggaga atcaggactt aaagaaggaa ctgctgaaat gtaaacaaga     60
 agccagaaac ttacagggga taaaggatgc cttgcagcag agattgactc agcaggacac    120
 atctgttctt cagctcaaac aagagctact gagggcaaat atggacaaag atgagctgca    180
 caaccagaat gtggatctgc agaggaagct agatgagagg aaccggctct tgggagaata    240
 taaaaaagag ctggggcaga aggatcgcct tcttcagcag caccaggcca agttagaaga    300
 agcactccgg aaactctctg atgtcagtta ccaccaggtg gatctagagc gagagctaga    360
 acacaaagat gtcctcttgg ctcactgtat gaaaagagag gcagatgagg cgaccaacta    420
 caacagtcac aactctcaaa gcaatggttt tctccttcca acggcaggaa aaggagctac    480
 ttcagtcagc aacagaggga ccagcgacct gcagcttgtt cgagatgctc tccgcagcct    540
 gcgcaacagc ttcagtggcc acgatcctca gcaccacact attgacagct tggagcaggg    600
 catttctagc ctcatggagc gcctgcatgt tatggagacg canaagaaaa aaaaaaaaag    660



      <210> 1430
      <211> 422
      <212> DNA
      <213> Homo sapiens


      <400> 1430
 ttgcaccagg atctaaagtc aggagaggtc acccttgcag agattgatgt catcttcaag     60
 gactttgtga ataaatacac ggacctggat tcagaactta agatcatgtg caccgtggac    120
 caccagggcc aaagagattg gatcaaggac cgagtggaac agatcaagga ataccatcac    180
 ctgcaccagg ctgtccacgc agccaaggtc atcttgcagg tcaaagagag cctgggactg    240
 aacggtgact tcagtgttct caacacttta ctaaatttta ctgataactt cgacgacttt    300
 cgccgtgaaa cactggacca gatcaaccag gagctcatcc aggccaaaaa gctgctccag    360
 gacatcagcg aggcccggtg caaggggctg caggctctgt ccctgagaaa ggagttcatc    420
 tg                                                                   422



      <210> 1431
      <211> 3380
      <212> DNA
      <213> Homo sapiens


      <400> 1431
 ctgatacccc agcttggcac ggggacgcag ccatggcgga ggcggctttg gaagccgtgc     60
 ggagcgagtt acgagaattc ccggccgctg caagggagct ctgcgtgcct cttgctgtgc    120
 cctacctgga caaaccccca actccgctcc acttctaccg ggactgggtc tgccccaaca    180
 ggccgtgcat tatccgcaac gctctgcagc actggccggc cctccagaag tggtccctcc    240
 cctatttcag agccacagtg ggctccacag aggtgagtgt ggccgtgacc ccagatggtt    300
 acgcggatgc cgtgagaggg gatcgcttca tgatgccagc tgagcgccgc ctgcccctga    360
 gcttcgtgct ggatgtgctg gagggccggg cccagcaccc tggagtcctc tatgtgcaga    420
 agcagtgctc caacctgccc agcgagctgc cccagctgct gcctgatctg gaatcccatg    480
 tgccctgggc ctccgaagcc ctgggaaaga tgcccgatgc tgtgaacttc tggctggggg    540
 aggcggctgc agtgacttct ttgcacaagg accactatga gaacctctac tgcgtggtct    600
 caggagagaa gcatttcctg ttccatccgc ccagcgaccg gcccttcatc ccctatgagc    660
 tgtacacgcc ggcaacctac cagctaactg aagagggcac ctttaaggtg gtggatgaag    720
 aggccatgga gaaggcagag gtgtccagga cctgcctgct cacggttcgt gtcctgcagg    780
 cccatcgcct accctctaag gacctagtga ccccctctga ctgctacgtg actctctggc    840
 tgcccacggc ctgcagccac aggctccaga cacgcacggt caagaacagc agtagccctg    900
 tctggaacca gagctttcac ttcaggatcc acaggcagct caagaatgtc atggaactga    960
 aagtctttga ccaggacctg gtgaccggag atgaccctgt gttgtcagta ctgtttgatg   1020
 cggggactct gcgggctggg gagttccggc gcgagagctt ctcactgagc cctcagggtg   1080
 aggggcgcct ggtaagttga atttcgcctg cagagtctgg ctgaccgtgg cgagtggctc   1140
 gtcagcaatg gcgttctggt ggcccgggag ctctcctgct tgcacgttca actggaggag   1200
 acaggagacc agaagtcctc agagcacaga gttcagcttg tggttcctgg gtcctgtgag   1260
 ggtccgcagg aggcctctgt gggcactggc accttccgct tccactgccc agcctgctgg   1320
 gagcaggagc tgagtattcg cctgcaggat gcccccgagg agcaactaaa ggcgccactg   1380
 agtgccctgc cctctggtca agtggtgagg cttgtcttcc ccacgtccca ggagcccctg   1440
 atgagagtgg agctgaaaaa agaagcagga ctgagggagc tggccgtgcg actgggcttc   1500
 gggccctgtg cagaggagca ggccttcctg agcaggagga agcaggtggt ggccgcggcc   1560
 ttgaggcagg ccctgcagct ggatggagac ctgcaggagg atgagatccc agtggtagct   1620
 attatggcca ctggtggtgg gatccgggca atgacttccc tgtatgggca gctggctggc   1680
 ctgaaggagc tgggcctctt ggattgcgtc tcctacatca ccggggcctc gggctccacc   1740
 tgggccttgg ccaaccttta tgaggaccca gagtggtctc agaaggacct ggcagggccc   1800
 actgagttgc tgaagaccca ggtgaccaag aacaagctgg gtgtgctggc ccccagccag   1860
 ctgcagcggt accggcagga gctggccgag cgtgcccgct tgggctaccc aagctgcttc   1920
 accaacctgt gggccctcat caacgaggcg ctgctgcatg atgagcccca tgatcacaag   1980
 ctctcagatc aacggggagg ccctgagtca tggccagaac cctctgccca tctactgtgc   2040
 cctcaacacc aaagggcaga gcttgaccac ttttgaattt ggggagtggt gcgagttctc   2100
 tccctacgag gtcggcttcc ccaagtacgg ggccttcaat cccctctgag ctctttggct   2160
 ccgagttctt tatggggcag ctgatgaaga ggcttcctga gtcccgcatc tgcttcttta   2220
 gaaggtatct ggagcaacct gtatgcagcc aacctccagg gacagcttat actgggcctc   2280
 agagcccagc caattctggg gaccgctggg gtcaaggaac caggccaacc tgggacaagg   2340
 agcaggtccc ccttctgaag atagaagaac caccctcaac agccggcagr atagctgagt   2400
 ttttcaccga tcttctgacg tggcgtccac tggcccaggc cacacataat ttcctgcgtg   2460
 gcctccattt ccacaaagac tactttcagc atcctcactt ctccacatgg aaagctacca   2520
 ctctggatgg gctccccaac cagctgacac cctcggagcc ccacctgtgc ctgctggatg   2580
 ttggctacct catcaatacc agctgcctgc ccctcctgca gcccactcgg gacgtggacc   2640
 tcatcctgtc attggactac aacctccacg gagccttcca gcagttgcag ctcctgggcc   2700
 ggttctgcca ggagcagggg atcccgttcc cacccatctc gcccagcccc gaagagcagc   2760
 tccagcctcg ggagtgccac accttctccg accccacctg ccccggagcc cctgcggtgc   2820
 tgcactttcc tctggtcagc gactccttcc gggagtactc ggcccctggg gtccggcgga   2880
 cacccgagga ggcggcagct ggggaggtga acctgtcttc atcggactct ccctaccact   2940
 acacgaaggt gacctacagc caggaggacg tggacaagct gctgcacctg acacattaca   3000
 atgtctgcaa caaccaggag cagctgctgg aggctctgcg ccccaggcag tgcaaacgga   3060
 aggcggcagc gcaaggcccc cactgatggc cggggcccct gcccaccccc taactctcat   3120
 tcattcccct ggctgctgag ttgcaggtgg gaactgtcat tcacgcagtg cttcagagcc   3180
 tcgggctcag gtggcactgt cccagggtcc aggctgaggg ctgggagctc ccttgcgcct   3240
 cagcagtttg cagtggggta aggaggccaa gcccatttgt gtaatcaccc aaaacccccc   3300
 ggcctgtgcc tgttttccct tctgcgctac cttgagtagt tggagcactt gatacatcac   3360
 agactcatac aaaaaaaaaa                                               3380



      <210> 1432
      <211> 381
      <212> DNA
      <213> Homo sapiens


      <400> 1432
 ttgggtattc tccagtccaa ttacagctcg tgatgcgttg ggtattaaac acaccatggt     60
 gaagattcgt cccttgtcac aggccacaag agcagccaag gccaaagcta gagcttatgc    120
 tgagttcctc cagccagcaa aggagcgtcc tgagacttca gcagccctag ccagaaggtt    180
 agtcatcagt gcccttgggg ttcgaagtaa gcagagcaaa accgaacgag aagcagagct    240
 caagaaactg caagaagcca gagagagaaa gcggttggaa gccaagcaac gggaagacat    300
 ctgggaaggc agagaccagt ctacagtttg aacatcactc aatgaaaggg ataattccat    360
 gaatcagaaa atgtttccat t                                              381



      <210> 1433
      <211> 738
      <212> DNA
      <213> Homo sapiens


      <400> 1433
 atgtcgcagg ggacgactcc ctgggggccg accccggcgg gaaccacgcc cgaatcggag     60
 gtacaccgcc cctttccctt cccggtaccg gtgccggtac cagagacctc cgagcgctca    120
 ttcccagtcc gcggagtctg cggccaagcc aaatccggtc tccgaagagg cgccgcacgt    180
 ctggccccgg ctgcttatct cttcacccgg cagcagacaa gggagttaat acacagcgcg    240
 tgtgtgtcca tttccgttaa cacaatgcac gggctatcag tcgctattaa ttccaggagg    300
 tgtacctatt atagaaaata tgttattgat ttttccaaat ctgagatcat tggaatacca    360
 atatccaaga atatagatct aacagtggga accacagtca ctcaactaca aaatttaaat    420
 acagtgggaa taattggatc ccgaggtggc agaggccaag tggcagcact caactgtgac    480
 aggcaaggac acctctggct ttttaccagg gtaactgtgc actggagaat gggaaatgat    540
 cggacatttt ggggactact ggacactgtc tctgagctga tgtttattcc agggaaccca    600
 aaacatcatt gtggccctcc agttaaagta ggggcttatg gagatcaggt tgcactgatg    660
 gcctcatgga gagttcccta tgatcagttg acagaggaac agaagactag ggcctggttc    720
 acagatggtt ctgcatga                                                  738



      <210> 1434
      <211> 1918
      <212> DNA
      <213> Homo sapiens


      <400> 1434
 ctagcttggc acgaggcggg acgccggcag ggttgtggcg cagcagtctc cttcctgcgc     60
 gcgcgcctga agtcggcgtg ggcgtttgag gaagctggga tacagcattt aatgaaaaat    120
 ttatgcttaa gaagtaaaaa tggcaggctt cctagataat tttcgttggc cagaatgtga    180
 atgtattgac tggagtgaga gaagaaatgc tgtggcatct gttgtcgcag gtatattgtt    240
 ttttacaggc tggtggataa tgattgatgc agctgtggtg tatcctaagc cagaacagtt    300
 gaaccatgcc tttcacacat gtggtgtatt ttccacattg gctttcttca tgataaatgc    360
 tgtatccaat gctcaggtga gaggtgatag ctatgaaagc ggctgtttag gaagaacagg    420
 tgctcgagtt tggcttttca ttggtttcat gttgatgttt gggtcactta ttgcttccat    480
 gtggattctt tttggtgcat atgttaccca aaatactgat gtttatccgg gactagctgt    540
 gttttttcaa aatgcactta tattttttag cactctgatc tacaaatttg gaagaaccga    600
 agagctatgg acctgagatc acttcttaag tcacattttc cttttgttat attctgtttg    660
 tagataggtt ttttatctct cagtacacat tgccaaatgg agtagattgt acattaaatg    720
 ttttgtttct ttacattttt atgttctgag ttttgaaata gttttatgaa atttctttat    780
 ttttcattgc atagactgtt aatatgtata taatacaaga ctatatgaat tggataatga    840
 gtatcagttt tttattcctg agatttagaa cttgatctac tccctgagcc agggttacat    900
 catcttgtca ttttagaagt aaccactctt gtctctctgg ctgggcacgg tggctcatgc    960
 ctgtaatccc agcactttgg gaggccgagg cgggccgatt gcttgaggtc aagtgtttga   1020
 gaccagcctg gccaacatgg cgaaacccca tctactaaaa atacaaaaat tagccaggca   1080
 tggtggtggg tgcctgtaat cccagctacc tgggaggctg aggcaggaga atcgcttgaa   1140
 cccggggggc agaggttgca gtgagctgag tttgcgccac tgcactctag cctgggggag   1200
 aaagtgaaac tccctctcaa aaaaaagacc actctcagta tctctgattt ctgaagatgt   1260
 acaaaaaaat atagcttcat atatctggaa tgagcactga gccataaaag gttttcagca   1320
 agttgtaact tattttggcc taaaaatgag gtttttttgg taaagaaaaa atatttgttc   1380
 ttatgtattg aagaagtgta cttttatata atgatttttt aaatgcccaa aggactagtt   1440
 tgaaagcttc ttttaaaaag aattcctcta atatgacttt atgtgagaag ggataataca   1500
 tgatcaaata aactcagttt tttatggtta ctgtaaaaag actgtgtaag gcagctcagc   1560
 accatgcttc tcgtaaaagc agcttcaatt atccactggg gttatctttt gacaacttgc   1620
 cattatctga tgttacacaa ttcaatagca agcaagtttg agacaatcgc agtttaaaag   1680
 catgaaccat ttaacaaaaa gtggaataat taaagataaa gcacttcttc ccaaagggaa   1740
 ttatcaccta gtgaaaaatt atgcatttca tctactcagt taccgactgc aagtctctcc   1800
 tcgctctagc tctcaagcct ttgggtgaat attcctgtga aatatatctt caacttgaaa   1860
 gttcatactc ccaatcaaaa actccctttt actgagtttg cagtactgta tttgcact     1918



      <210> 1435
      <211> 1980
      <212> DNA
      <213> Homo sapiens


      <400> 1435
 tctagggaat ttggccaccc taggcagaaa gtggtaataa cacagtcagc tcttgattgt     60
 tctaatataa tggccaattt gcatattatc cacgtctttg accagttctt ctttcttctg    120
 tggcttttct tttagtcatt acatttacag ctcacccaat atagtacaga agggatattc    180
 aaattttgca acttgttgga tgaagaaggt ccttggggag gagactgaaa ctactgattg    240
 aaaaatcagg tttataaata atttgaacat ttcatttctt tgtaattgac atatacttct    300
 atatataatt atgagtttaa tgaagtgaga taatttaaga tgatcacaca ataaaacttt    360
 acagccaaaa tacaaagtct tcatcttatt ttcctacttc attttttttc atgttcttag    420
 taagtgcatt tttctacttt attttttgaa aagaacattc atttttgaaa agtttatttc    480
 accaaggacc aatcttttgt tgatgttcaa atttaaattg ttctttcata tctgtctcat    540
 aggagaaaaa catgaaaaat tgcttctgtg gtagtttctt ctaggttttc aagtactctt    600
 atagtagcaa ctggttcaaa atactgcttt gtttcaaagc atacagttta gatgtatctt    660
 cactgatgat gggaacattt tcattttgtt cctgagctgt caggtcactt tcactgtcag    720
 atagtgtaca caggagagtg tcattttcat aggttggaaa ataatactcc agttgatccc    780
 acgtctttct atcggggagc agcgaagtgt gtttagtttc ttccatgtga gttcttaagt    840
 ctgctttgga tttgaacttc acatggcagc cataacatct gcattggtga acttgcctcc    900
 gaataaaatt gaccagtttc acttgctgat agaaatttaa tccaagttct gactttattt    960
 tgagaagatc aaattcgtgt gcatcctcca tgtggacata caacttctca attgtttctg   1020
 cttgcttttc acaaaataag cagactgcag aggcagggtg ttcttcccaa tcagaccagt   1080
 catcttcctg atggtccagc aactcccgat catcttccaa ctgaacttct tcccacgatt   1140
 ttccaagttc caaataattg atgacataaa atctgtcata ttctctgttc ttaggattaa   1200
 tcttacgatg ctgttttttc ctcatgtgat ctttaagtgt atttttgtcc ctgaaggtct   1260
 tctcacagta caagcactgc aaattgtcaa gctttttctg taatgtacac aaaaattcat   1320
 tgcagtttac aatgttgtct ggcaatccaa tgttgaaagc atgttctctg gccatgtggt   1380
 tcaaaataac agatctgttt ccaaggaatt cttcattgca aaacatacaa acgccatgaa   1440
 aattggtatc atttcgttct tgctgctgtt gttccagaat ttctctcagt ctctgtttct   1500
 gaagctcttc tctaagaatt ctatcttctg gtaaaacgtc acataacaaa aaataattct   1560
 cttgttcttc aaatggagca gtggaattaa ttcttattac actacaaaaa tctgtgatgg   1620
 gctgttcagt gaaccttttc ctccaatata aaatgtacct ttggaaatca gcaaccaact   1680
 tgacatcagc tatgacaatc ttatgctcaa taatcatgtg cttcagaagt ttgtcttgtt   1740
 cagccacagg aaaatgttct tcacagaaaa tacaaggcac agatggagaa ccttctaaag   1800
 tggtggtgcc acctggactt tctggcaggg aaagcggctc caggatacaa tccttactgt   1860
 ccccataacc tacacccccg actgtgctgc agctcccatc acggtcttcc tgcattcggg   1920
 cgacagcccc ctgggtcttg gaagcagcca ttacccggca gaaaagaacg gacgcgtggg   1980



      <210> 1436
      <211> 703
      <212> DNA
      <213> Homo sapiens


      <400> 1436
 cctgccccct tggctgaggg ggccttcttg gctgaggcta gcctcttgaa gctgtcccct     60
 gcaacaccta cttctgaggg tccaaaggtg gtgagcgtac agttgggtga tggtacaagg    120
 ctgaaaggca ctgtgctgcc tgtggccacc atccagaacg ccagtactgc catgctgatg    180
 gcagccagtg tggctcgcaa ggctgtggtg ctgcctgggg ggactgccac cagccctaag    240
 atgattgcta agaacgtgct aggcctggtg ccccaagccc tgcctaaggc tgacgggcgg    300
 gcagggctgg ggactggggg acagaaggtg aatggtgcct cggtggtgat ggtgcaacct    360
 tcaaagacag ctactgggcc aagtacaggg ggcggcacag tgatatcacg gacccagtcc    420
 agcctggtgg aggccttcaa caagatcctc aacagcaaga acctgctccc tgcctatagg    480
 ccaaacctga gcccaccagc tgaggctggg ctggccctgc ctcccaccgg ctaccgctgc    540
 ctggagtgtg gggatgcctt ctcattggag aagagcctgg cacggcacta tgaccgtcgg    600
 agcatgcgca tcgaggtcac ctgcaaccac tgcgcccgcc gcctggtctt cttcaacaag    660
 tgcagcctgc tcctgcatgc acgtgaacac aaggacaagg ggc                      703



      <210> 1437
      <211> 1227
      <212> DNA
      <213> Homo sapiens


      <400> 1437
 ctgtggaatt cggacgaggg cgcccgttgt cacggccccg ggcggagctc tgctgcgggc     60
 gggcgctgga cggctgcttc ggggaggcgt ccaggagcta ctgcggccgc gacatgaagg    120
 gaacgcccct gacctggcct gcaacttcag cctttctcaa aatcggggca cggtcatcgt    180
 ggagcgctgg tggaaggtac cgctggccgg ggagggccgg aagccgcgcc tgcaccggcg    240
 acatcgcgtc tataagctgg tggaggacac gaagcatcgg cccaaagaaa acctggagct    300
 catcctgacg cagtcggtgg agaatgttgg agtccggggt gacctggtct cagtgaagaa    360
 atctttaggc cggaatcgac tccttcctca gggactggct gtatatgcat cccctgaaaa    420
 caagaagctg tttgaagagg agaaattgct gagacaagaa ggaaaattag agaagatcca    480
 gaccaaggca ggtgaggcga cagtgaaatt tctaaaaagc tgtcgcctgg aggtagggat    540
 gaagaacaat gtcaaatggg agctgaaccc tgaaatagtt gcccgccact tctttaagaa    600
 tcttggtgtt gtggttgccc cacatacatt aaagttacca gcagagccta tcacacggtg    660
 gggcgagtat tggtgtgagg tgacggtaaa tgggcttgat actgtgagag tgcctatgtc    720
 tgtcgtgaac tttgagaagc ccaagaccaa aagatataag tactggttag cccagcaagc    780
 tgccaaggct atggccccca ccagccccca gatctaaatc tactctccct ccaaggcagc    840
 aaagcagaat cgggagcagt ggagcagaaa tgtgcaagca ccctgatctc actcccagct    900
 ctgaccaaat acagaatttt agagaacatc tgaagacatc agactgcact gcgtatacat    960
 gttgaattct tcatttttgc catctttaac tgtcatcact ggggcaggga agtcctgttc   1020
 cagaagtacc aggctgtaga tttgataagc tagatgcagt agaccgaaac catccaaaac   1080
 ctgtttagct tcttcctcca ttggagttta ttgggacaaa caggagagcc agccattgtc   1140
 tccagtactt gcctcattct catcatccaa actgaacatt tgtatcccaa gcagaaataa   1200
 agagaatatg ttctttttaa aaaaaaa                                       1227



      <210> 1438
      <211> 432
      <212> DNA
      <213> Homo sapiens


      <400> 1438
 acaagggccc ctcgtacggg ctggcggccg aggtcaagaa ccggctcctg tccaaatatg     60
 acccccagaa ggaggcagag ctccgcacct ggatcgaggg actcaccggc ctctccatcg    120
 gccccgactt ccagaagggc ctgaaggatg gaactatctt atgcacactc atgaacaagc    180
 tacagccggg ctccgtcccc aagatcaacc gctccatgca gaactggcac cagctagaaa    240
 acctgtccaa cttcatcaag gccatggtca gctacggcat gaaccctgtg gacctgttcg    300
 aggccaacga cctgtttgag agtgggaaca tgacgcaggt gcaggccaag actaaggggc    360
 tgcagagcgg ggtggacatt ggcgtcaagt actcggagaa gcaggagcgg aatttcgacg    420
 atgccaccat ga                                                        432



      <210> 1439
      <211> 501
      <212> DNA
      <213> Homo sapiens


      <400> 1439
 gctcccgctg ctgggggaga gctgggtttt catggggcgg cagccgaggc aggacccgca     60
 gccatgaacc gcttcaatgg gctctgcaag gtgtgctcgg agcgccgcta ccgccagatc    120
 accatcccga ggggaaagga cggctttggc ttcaccatct gctgcgactc tccagttcga    180
 gtccaggccg tggattccgg gggtccggcg gaacgggcag ggctgcagca gctggacacg    240
 gtgctgcagc tgaatgagag gcctgtggag cactggaaat gtgtggagct ggcccacgag    300
 atccggagct gccccagtga gatcatccta ctcgtgtggc gcatggtccc ccaggtcaag    360
 ccaggaccag atggcggggt cctgcggcgg gcctcctgca agtcgacaca tgacctccag    420
 tcacccccca acaaacggga gaagaactgc acccatgggg tccaggcacg gcctgaagca    480
 gcgccacagc tgccacctgg t                                              501



      <210> 1440
      <211> 522
      <212> DNA
      <213> Homo sapiens


      <400> 1440
 cggacgcgtg gggcgcggag cactgtttct tttcagctct cacagaacct tcagcatccc     60
 cagctgccgg tcttggcatc ttcgaagtaa ggagaggtga gaatcctgtt gcatggtcaa    120
 gtctggcttt attttcttct gagtatttgg gcttggaggg tagggggtgg gggctgatgc    180
 acattgtatt ttttttccca tgtatcccca aagtctaaac gaatcatatt tttttgtagc    240
 ttcttctgat aaagtaacat atgctcaaag tctgtagaaa cttacttaaa gtttctaaag    300
 tggtaagagt tggaggtggg agatccagac tgtcaagttc tgtcacaact gctttatggg    360
 catctcatga gcacctactt taggttcagg atggttgaat acaaccagaa tagcccatta    420
 tcctgagaaa tacacatctt aagaaaactg gaagaatcat cttcctttgg ctttaaacat    480
 ttatctatct atctatctat ctatctatct atctatctaa ct                       522



      <210> 1441
      <211> 525
      <212> DNA
      <213> Homo sapiens


      <400> 1441
 atgttgagac agagaagatg gtacctgctg catccttgga gattcaaaat gtcatcatgg     60
 cattctaggc tagactggca gtggagaaat cacttcaact ttgaccactt tgaaattttg    120
 cgagccattg ggaaaggcag ttttgggaag gtctgcattg tacagaagaa tgataccaag    180
 aagatgtacg caatgaagta catgaataaa caaaagtgcg tggagcgcaa tgaagtgaga    240
 aatgtcttca aggaactcca gatcatgcag ggtctggagc accctttcct ggttaatttg    300
 tgttcaccag caatggatcc aaaccaagaa gaaatccctg atttacctga aaaagaattc    360
 aggaggttag ctattaagct aatcagggag gaaccagaga aaggtgaagc tcagtgcaag    420
 ggaatccaaa atatgataca agaagtgaag ggagaaatat tcaagcaaat agatagctta    480
 aagaaaaaac aatacaaaat tcaggaaact ttagacacac tttaa                    525



      <210> 1442
      <211> 3093
      <212> DNA
      <213> Homo sapiens


      <400> 1442
 ttctatgacc tcctgcgcat cacgttgggc agaaggggac agtacgttat gctctcggtg     60
 tgcctggagc gagccatgaa ggttgcgttt ggagaatttc acctttggta ccaggtggcc    120
 ctctccatgg tggcttgtgg gaagtcagcc tacgctgtgt ccctgctgcg ggagtgtgtg    180
 aagttgcggc cctcggaccc caccgtgccc ctgatggccg cgaaggtctg catcgggtcc    240
 cttcgctggc tagaggaagc agagcacttt gccatgatgg tgatcagcct cggagaggaa    300
 gccggggagt tcctccccaa gggctacctg gctctgggtc tcacctatag cctgcaggcc    360
 accgacgcca ccctgaagtc caagcaagat gaattgcacc ggaaggcact gcagacgctg    420
 gagagggctc agcagctggc gcccagtgac ccccaggtca tcctctatgt ctcgctgcag    480
 ctggccctcg tccgacagat ctccagtgcc atggagcagc tgcaggaggc cctgaaggta    540
 cgcaaggatg atgcccacgc cctccacctg ctggcactgc tcttctctgc ccagaagcac    600
 caccagcatg ccctggatgt tgtcaacatg gccatcaccg agcaccctga gaacttcaac    660
 ctgatgttca ccaaggtgaa gctggagcag gtgctgaaag gcccagagga agccctcgtg    720
 acctgcagac aagtgctgag gctgtggcag accctgtaca gcttctccca gctgggaggc    780
 ctagaaaagg atggcagctt cggtgagggc ctcaccatga agaagcagag tggcatgcac    840
 ctgactttgc ctgatgccca tgatgcagac tctggctccc ggcgggcttc gtccatcgcc    900
 gcctcccggc tggaggaggc catgtcagag ctgactatgc cctcttcggt cctgaagcag    960
 ggccccatgc agctgtggac caagctggaa cagatctggc tgcaggctgc tgagctgttc   1020
 atggagcagc agcacctcaa ggaagcaggt ttctgcatcc aggaggcggc gggcctcttc   1080
 cccacttctc actcagtact ctatatgcgg ggccggctgg ctgaggtgaa gggcaacctg   1140
 gaggaggcca agcagctgta caaggaggcg ctcacggtga acccagatgg cgtgcgcatc   1200
 atgcatagcc tgggtctgat gctgagtcgg ctgggccaca agagcttggc ccagaaggtg   1260
 cttcgtgatg ccgtggagag gcagagtacg tgccacgagg cgtggcaggg cctgggcgag   1320
 gtgctgcagg cccagggcca gaacgaggct gccgttgact gcttcctcac cgcccttgag   1380
 ctggaggcca gcagccctgt actgcccttc tccatcatcc ccagagagct ctgacgacgc   1440
 tgcagccgca gggagggagg ggctggccag agggagaggc agcagggaac gtgggtcagg   1500
 gtggggcaac agtggcatca ggtgcggggc ctcagggaaa tacatcttta gtgaacgcct   1560
 ctgcagctgc agccctcgtt ctcttggctg ggccaagagg gccttcctgg atttctttgt   1620
 tggtgccttg ggaaacagtc tgacttgaac cctaagtgcc tttggagagt tttgtggtga   1680
 ccagacttgc tccccaagag ctgggcagcg gggagcctca cagctgtcct tcaccctcac   1740
 ccatgcctct ggcttggggt ctgggtgggg ggttctcact ccccactctc agcacagtac   1800
 agacttctgg atctctctca ggtcttgccc agggcggtca caatgtgaag aaactgcggg   1860
 caagtgggaa gactatgaga tttctgggtt cccttctcag acttggagtt agtagatgat   1920
 tcctgcattg cccctgcttg ccctctgaga ccagctgggc cccaccttgc tctttccccc   1980
 tgctaccaag tgcctttggg gcctctgggg tctgaccagg ggtactgagc accggcccta   2040
 acacttccat ctccacccac cccatctccc tggcgatgtg ctccagccca agcagcctcc   2100
 gtaggcttta gatcctgtgg ttgccagatc cagtcctttc taataccctg agtcaacaca   2160
 ttactcctgc aggtcttagg ctacaatgca ggtcccttga gggccaccaa catggaggta   2220
 ggcagtttct aggactgtcc ccagtacatc tcaccaccca cagccctttt tttgccttga   2280
 ttcgagcctc accctggcct tttggcttcc cctgcctgag agagacctga ggaggggaca   2340
 gagcccagcc cctctcctgt ggctgagcag gcctctgtgt ccatgacacc tgtcttccgg   2400
 gcctgggggc tgtgggtgta tgtcctccct actggcttcc ccggcccctg ctgcatgatg   2460
 ctcttggaac tcttccccaa ggagtcagtc ccccaggcct atcaggggat ccttttgtat   2520
 ctgcactttg ggttttagtt tcaaagctcc atcaggtaca gcttgcattt caggatgtgt   2580
 ggaaagctcg ggtgagggct gccctggttc atcatagctc caccttcctc ggaaggagtg   2640
 ggctgttgga gaccccccat ccatggcaca ctagctcagc actgcatttc ccgagatgat   2700
 tcccaagaca gctggtgcct cctggctttc ctgtgccagg ccaaggggca ccacagagga   2760
 ccctggatcc tttgcctctt cttggttgaa ggatctctat gtatgtgtgt atataaatat   2820
 agttttttat ctatatatat aaaatagaga tctatttttt ttctggaatt ctgttagaaa   2880
 agtaaagaaa aagcaaatgc tgttggttta tctcagggtg cccaaagtgg ttatagtcaa   2940
 tttttggtac taggaaaggc acccaatgca tttcctgact tttaagcatt tccttgttgg   3000
 aagcagcaga gggccaggcc aagttgctga cagtgacttt gcaggttgaa taaagaaacc   3060
 cttggagggg aagcaggctt gtttgaaaaa aaa                                3093



      <210> 1443
      <211> 564
      <212> DNA
      <213> Homo sapiens


      <400> 1443
 ttttgccttt cacaggaatg ttttattgtc tctgcctgga cttctaacat agcatatgag     60
 gtgaaaacac tgctttagta aaaatggaat actcttggtt acatgaaatc ccatccctcg    120
 tccttcaggt ccactggagg agaagtccct cattccttgg gattggtgac gacagccgtg    180
 gtggaatagg agtaggggct cagcagggcg gcaatggtgt ggtggcagca ggcgcagccc    240
 agcctcgaaa tgcagaacga cgccggcgag ttcgtggacc tgtacgtgcc gcggaaatgc    300
 tccgctagca atcgcatcat cggtgccaag gaccacgcat ccatccagat gaacgtggcc    360
 gaggttgaca aggtcacagg caggtttaat ggccagttta aaacttatgc tatctgcggg    420
 gccattcgta ggatgggtga gtcagatgat tccattctcc gattggccaa ggccgatggc    480
 atcgtctcaa agaacttttg actggagaga atcacagatg tggaatattt gtcataaata    540
 aataatgaaa acctaaaaaa aaaa                                           564



      <210> 1444
      <211> 340
      <212> DNA
      <213> Homo sapiens


      <400> 1444
 tgcacgaggt gagcttcttc tttctagata agcaccatag gaggtaaagg ggcatttcct     60
 ggcccttggg tattttgtat caactgccaa agctgaaaat cttccctagc ggttatggtc    120
 atcgtgtccc caggctcaaa accagatccc tctcttctta aaggcttcgc tgcatcacca    180
 catttcagta tcacatacag actaacttct gcctgccatg aattctcagc ggtttccaca    240
 cccttttgac tccataacca cttctgatga tttaaggtct gttttgcagc attacaactc    300
 tctgacctga ctcacatgca atccggacac ccaggaccgt                          340



      <210> 1445
      <211> 2526
      <212> DNA
      <213> Homo sapiens


      <400> 1445
 tttcgtgctt ctaggaagta gaacgccggc tcgcatgcct gcccgcccgc cagcctgccg     60
 ggtacggcct tttccgccgg ggcttccagg tcaaagaatt cgcctttgcc gctaccgctt    120
 tcttaccctc cgcacccgtt aagttctccg gtcgggcggc agtctctgaa cacttagccg    180
 cgccatccgg ggtcacaccg cctggaagga ggtgacgggg gcggcgcggg gcgcggacac    240
 tccccgctga gagtccgcct gccatggact cggaatatta cagcggcgac cagtcagatg    300
 atggtggtgc taccccagta caggatgaac gggattcagg gtcagacggt gaggatgatg    360
 taaatgagca acactccgga tcagacactg gaagtgtaga acgtcattca gagaatgaaa    420
 ctagtgatcg agaagatggc ctccccaaag ggacatcatg tgacagactc tgagaacgat    480
 gagcccttaa atcttaatgc tagtgactct gaaagtgagg agcttcacag gcaaaaggac    540
 agcgactctg aatctgagga acgtgcagag cctcctgcaa gcgattctga aaatgaggat    600
 gtcaatcagc atgggagcga ctctgagagt gaagagacca ggaaattacc tggtagtgac    660
 tctgaaaatg aggaacttct taatgggcat gcaagtgact cagaaaacga agatgttggg    720
 aagcatcccg ccagtgattc tgagattgag gagctccaga agagtcctgc tagtgactct    780
 gaaacagaag atgctctaaa acctcaaatc agtgactctg agagtgagga acccccaagg    840
 caccaagcca gtgactccga aaatgaggag cctcccaaac ctcgaatgag tgattctgaa    900
 agtgaggagc ttcctaaacc tcaggtcagt gattcagaaa gtgaggaacc cccaaggcac    960
 caggccagtg actctgaaaa tgaggagctt cccaaacctc gtatcagtga ctcaaaaagt   1020
 gaggaccctc cgaggcacca ggccagtgac tcagaaaatg aagagcttcc caaaccccga   1080
 atcagtgatt cggaaagtga ggatccccca aggaaccagg ccagtgattc ggaaaatgag   1140
 gagctaccca aaccccgagt cagtgactct gagagtgagg ggcctcagaa ggggcctgcc   1200
 agtgactcag aaactgagga tgcgtccaga cacaaacaga agccagagtc agatgatgac   1260
 agcgacaggg agaataaggg agaggataca gaaatgcaga atgactcctt ccattcagac   1320
 agccatatgg acagaaaaaa gtttcacagt tctgatagtg aggaggaaga acacaaaaaa   1380
 aaaaaaatgg acagtgatga agatgaaaaa gagggtgagg aggagaaagt agcgaagaga   1440
 aaagctgctg tgctttctga tagtgaagat gaagagaaag catcagcaaa gaagagtcgt   1500
 gttgtctctg atgcagatga ctctgacagt gatgctgtat cagacaagtc aggcaaaaga   1560
 gagaagacca tagcatctga cagtgaggaa gaagctggga aagaattgtc tgataagaaa   1620
 aatgaagaga aggatctgtt tgggagtgac agtgagtcag gcaatgaaga agaaaatctt   1680
 attgcagaca tatttggaga atctggtgat gaagaggaag aagaatttac aggttttaac   1740
 caagaagatc tggaagaaga aaaaggtgaa acacaggtaa aagaagcaga agattcagat   1800
 tctgatgata acataaagag aggaaaacat atggactttc tgtcagattt tgagatgatg   1860
 ttgcagcgaa aaaagagcat gagtggcaag cgcagacgga accgcgatgg tggcaccttt   1920
 attagtgatg cagacgacgt cgtgagtgcc atgatcgtca agatgaatga agctgctgag   1980
 gaagacagac agttgaacaa tcaaaaaaag ccagcactga aaaaattaac tttactgcct   2040
 gctgtagtta tgcaccttaa gaagcaggac cttaaagaaa cattcattga cagtggtgtg   2100
 atgtctgcca tcaaagaatg gctctcacct ctaccagata ggagtttgcc tgcactcaag   2160
 atccgggagg agctgctgaa gatcctgcaa gagctgccta gtgtgagcca ggagaccctg   2220
 aagcatagtg ggattggacg agcagtgatg tatctctata aacaccccaa ggagtcaagg   2280
 tctaacaagg acatggcagg gaaattaatc aatgagtggt ctaggcctat atttggtctt   2340
 acctcaaact acaaaggaat gacaagagaa gaaagggagc agagagatct agaacagatg   2400
 cctcaacgac gaaaaatgaa cagcactggt ggtcagacac ccagaagaga cctggaaaag   2460
 gtgctgacag gagaggagaa ggctcttaga cctggagatc ctggattctg tgccccgtgc   2520
 aagggg                                                              2526



      <210> 1446
      <211> 1052
      <212> DNA
      <213> Homo sapiens


      <400> 1446
 tttttttttt ttttggattt gcaaatacag tttattttac agaaattcaa cattataaac     60
 agcaggcacg tgccagcccg ctcgcccccc tccccccggc caactcccag gtgcagacca    120
 tgctatgcag agagtgagca gcaacgcgcc cctactgctt tggagtgaga gtcgaaagcc    180
 gagggaacct gcctgcacca catcctgcct gccccacaca cgcacacgcc tgctcgctgc    240
 gcaggccacc aacagtctgt ctgggcccag ccagcgctgg accccattac atggatccag    300
 cccagttctc caattccttc atgtcgtcgt cctcctcttc ttttttcttg gcgggttttg    360
 atggtagggc tatagaggga acatttggta gagggactgt ttcgggtcca ctgatttcca    420
 gcaaattctt gtctagttcc tcctgttcta gttcttctaa ttccgccatg agctcatcct    480
 cgtcaaactc ttctccaaac cctacaggtt tcgaaattgc tgttgaaatc tcctctgcaa    540
 gttcttgctg gtcagcaatg tcctgcatta actcatcaac tttatcgatg tccatgttgt    600
 catgggccgc cttcatggcc ttggcggcat agcccatgtt cttgagcacc tcggtgttgg    660
 tgttggcatt ctccagggcc tcccgctgga actcgatggt tgataatgtg ccgtcgatct    720
 gcgccagctg cttctcatac ctcttcttac gcttcagtgc ctggagggcc gcgcgcttgt    780
 ttttggtgcc gtgcttcttg gcggccgtca gctcctgctc gattttcttc tccaggaact    840
 cctgtttctt gcttaacatc tcttccgtgt cccgcagccg ctggatggcc tcctgggggg    900
 tcgggccgcc cttgccggcc ttaccccctc cagccccgaa cagcttcccg aacaccgaca    960
 tggttgctgc tcgccgcgcc ggccttcgcc gcccgctccg gctcggctcg gctcggctcg   1020
 gctcgggtcg gacgaaatcg tcgacccggg aa                                 1052



      <210> 1447
      <211> 261
      <212> DNA
      <213> Homo sapiens


      <400> 1447
 ggacctgaag cccgagaaca tcttgctgga tgaccacgtg tgtaagggtg cctgggctcc     60
 ggaggtggtg aagatgaacg gtacacgttc agccctgact ggtgggcgct cggctgcctc    120
 cttacgagat gatcgcaggc cagtcgccct tccagcagag gaagaagaag acaagcggga    180
 ggaggtggag cggctggtga aggaggtccc cgaggagtat ccgagcgctt ttccccgcag    240
 gcccgctcac tttgctcaca g                                              261



      <210> 1448
      <211> 6742
      <212> DNA
      <213> Homo sapiens


      <400> 1448
 cgcgcgccaa tgatgactaa ggctgtgccg gaggaacccc gaaagccagg aaggctgacc     60
 caggccctga actcacccct cacctgggag catgtttgga tttgcgtccc cggcggcact    120
 cctgactgtc tgacagacac cttcagagtg aagaggccac atctcaggcg ctctgccagc    180
 aacggtcatg tccctgggac tcctgtctac agagaaaaag aagatatgta tgacgagatt    240
 attgagttaa agaagtcatt gcacgtgcag aagagcgacg tggacctgat gagaacgaag    300
 ctccggcgcc tggaggagga aaacagcagg aaggaccggc agatagagca gctcctggat    360
 cccagccgcg gcacggattt tgttcggact ctggcagaga aaaggcccga tgccagttgg    420
 gtcattaacg ggctgaagca gaggatcctg aagctggaac agcagtgcaa ggagaaggac    480
 ggcaccatca gcaaactcca gaccgatatg aagactacca acctggaaga gatgcggatc    540
 gccatggaga catactacga ggaggtgcat cgtctccaga ccctcttggc aagttctgaa    600
 accaccggaa agaagcccct gggggagaag aagacgggcg ccaaaaggca gaagaagatg    660
 ggcagtgccc tcctgagctt gtcccggagt gtccaggagc tcacggaaga gaaccagagc    720
 ctgaaggagg acctggaccg cgtgctgagc acctccccaa ccatctccaa gacacagggt    780
 tatgtggagt ggagcaagcc ccggctgctg aggcgcattg tggagctgga gaagaaacta    840
 agtgtgatgg agagctcaaa atcacacgcc gcagagccag tcagatcaca cccgccagcc    900
 tgccttgcat ccagctctgc gctgcacaga cagccacgag gggaccgcaa caaggaccac    960
 gagcgtctcc gaggggctgt gagagacctg aaggaagagc ggaccgcgct gcaggagcag   1020
 ctgctgcaga gagatttgga ggtgaagcag ctcctgcagg cgaaggccga cctggagaag   1080
 gagctggagt gcgcgaggga gggcgaggag gagaggagag agcgagagga ggttttgaga   1140
 gaggagattc agacacttac cagcaagctc caagaattgc aagaaatgaa gaaagaagag   1200
 aaagaggatt gcccggaagt tcctcataag gcccaagagc tcccagctcc cactcccagc   1260
 agcaggcact gcgagcaaga ctggccgccg gattccagcg aggaggggct cccgcggccc   1320
 cgctccccct gctctgatgg gagaagagac gccgcggcca gagtcctgca ggcccagtgg   1380
 aaggtgtaca agcacaagaa aaaaaaggct gttctggatg aggcggctgt ggtgcttcag   1440
 gcagctttca ggggacatct cacgcggaca aagctcttag caagcaaagc acatggctca   1500
 gagccaccca gcgtgccagg cctcccagac cagagctctc ctgtgccccg cgttccgagc   1560
 cccatcgccc aggccacggg cagccctgtg caggaggagg ccatcgtcat catccagtcc   1620
 gctctgcggg cacacctggc ccgggccagg cacagtgcta ccggtaaaag aaccaccacc   1680
 gcagcttcta ccaggaggag atcggcttca gccacacacg gggacgcctc ctccccaccc   1740
 ttcctcgcag ctcttcctga cccctctccc tcagggccac aggccgtggc acctctacct   1800
 ggggatgacg tcaactccga tgattccgac gatattgtca ttgcaccgtc tctgcccacg   1860
 aagaactttc cagtttaggt ccccgtcact gtctccacgc tgtgatggca gcgctgccga   1920
 ggacatagga accacgactg gaaagataat ttatcgtgtt aggagaagaa cgatgatacc   1980
 tacttaacac ctcagcatct gcgtggtgtc tctttgtgct tttgtttgtg gaaggagacc   2040
 caaatgcctt tactttattc tctggggagg gccagcggct cgcatccccc tcatctccag   2100
 ctgcagctcg gatggtggat tttcagtgcc aacagacaca tctgccgtga actcgcagat   2160
 gccagggagc cctgtagtga cacgttctct gacagcacct tgccgcctgc ccacgacctt   2220
 gaccgtgagg agctgctata cgcaaccagc gccgacacca tgccccctct tcctggtgac   2280
 accctcaaca accaggattt gctcgatctc agcccagcag gccaggcaga cacaccccgc   2340
 tgtgccttag gaaggtgtga gaccggcttc ccccatcccc acagcaaaac acggcctgtc   2400
 ccaagccagt gaggagctaa agacacccag gtccccaaat gatcttactc catgccccac   2460
 ccgctcacac cgtcctttcc cgtcaccctt gctatcccct ggagcactgc cctccagagc   2520
 tgcccttccc aggaaggaat ttggttggat tctgtcactg tggagaccaa gattttttaa   2580
 aattcccaat tacaaaagca gcatcacact tgcttctgag aacagcaggg tgatgtctgt   2640
 tcccaagctg gtggcgggag ccttagcctg tgtggggcca cccggggaag aggaggagag   2700
 gagggtgagg aggcaggctc gccgttccaa gggacagcat aggctcgtgg tggggcgtgt   2760
 tgcatctggt gtctgggaca gtccccgtca ccccatgtgt gcggcctctg cactcccaag   2820
 ctccatggct gggctgggct gggctgggct gggctgggcc gggcgtgcgg agcctgtgga   2880
 gccagcagct gcagaggcct aggagggagt tcctggggga agcgcacagt gtccagtgcc   2940
 catctcttgc ttgtgtgtga gattagccct tgctggggcg tcaagaggaa gagccttaga   3000
 cctgggcggg ccttcagggg catctagacc cctgcacagc ccaggcctgg tgtctgcatt   3060
 tccacagcac ccctgtgggg actcctgccg gggctggccg ctgtctcagg agagacccaa   3120
 tggttagaaa gccccttttt acacagctga cagcttctcc caaggcttcc gtccacgggg   3180
 acaggcttaa cccctgggcg ccttttctgc agcatggcgg ccttctgagt cacctaagct   3240
 gagcctgggt cattctctgt ggcggtcaga aggccgatgg ccccaacaca gtggcttgtg   3300
 aaagggagag aggaggctct gcatgtccac ctgctctatg ggaggaggac acaggtgtcc   3360
 ccagcccagc ctgttctctc ccagtcactc agggatgggg ccacccaaag tgcaggaccc   3420
 gccccaccct gcggttcgaa gcctggcccc tgtctccact tagcttctgt ttctgcagtg   3480
 ggtggaagcg agtcagcggg gggcctggct tgtgtacgtg ttttccttat ttggtctgtg   3540
 ggttgccaag tccatttttt tttccactga actggctggt aacttgatgg actgtgtaac   3600
 tgacacaggc cctctttaga cccctgcctt caccccaccc gcccgggtcc actccctggg   3660
 gcgctgtccc aagccatccc tgcttgccag ctcaaagctt caggtcctag gagccagtcc   3720
 acctcgaaag ccctgagaaa gtgagacacc tgcacattcg ctgggggaga ccctccgttc   3780
 tcttgtggca gctgctccca cttgttaaac caagctgttt ctgcgggacg tgctcactct   3840
 tgggaaccag tggcctagag ctttgggtta caggcatgga gagggctttc ctgcctcagg   3900
 cttggaggcc aatgttccat acataaaccg ccatgtcctc tggtgcagct gggctgctct   3960
 tttaaaagcc agcatccatc ttgaagctcg ctgggtaaat ggcaatgcat tctcaagcca   4020
 gtgtcttcag ctgatgccca gtgtccagtg ctggtcacca gtcccctttg ctgggtacag   4080
 cctgcctggc tgttctgtgg tcctggaacg ctgcagtgtg gttttgttcc atggagacag   4140
 taccaagcgg agaggcctcc ttgcccacgg ccccagggcc tgggggccag gggttctggc   4200
 cctgcgggga cttaggcagg aggggaagag aagcccatgg agccatggga ggggtgagct   4260
 gtgggcgggg cctagtcatg ggaggggtga gctgtgggcg gggcgagctg tgggtggggc   4320
 ctagccatgg gagaggtgag ctgtgaatgg ggctagctat gggtggggtg agctgtggac   4380
 agggcctagc catgggaaag gtgagctgtg ggcggggcct agtcacggga gaggtgagct   4440
 gtgggcgggg cctagtcatg ggaggggtga gctgtggatg gggcctagcc atgggagggg   4500
 tgagctgtga gtggggctga gccatgggag cagcaagctg gtggagtggg ctgggcggag   4560
 ctgtgggggc tgctggcagg gcctaggaaa gtagacaact cccgggggag acgaagtaga   4620
 gagtgagtcc ccaagaaagg gactcctgcc ccagcgtcaa gtgccaaagc aggccccatc   4680
 taccacttca gggtcgacgt tggtggcagg tgttgttcac ggtgtactga ttgtcactgc   4740
 aacacctcca catcaccttg aacttcaaga acagcagcaa agctgtatct gctatcagag   4800
 gctgttaggt agtccagctt taaaataaca cactctttct ctatcccatg ccctttaaac   4860
 aagcagccac aggagatgtc agtctccagg gcctggcccc actgtgttga cagcagtcat   4920
 gtctgttgag ctgacactgc tgaggctgaa gctggccctg tgcaggtggc tggtgagcca   4980
 caggtgcagt acccggaggt gtgctctccc ctagaggcct gtccccaact cctcccctag   5040
 aggcctattc ccgctgctca cagacctcag cagaggcacc agctggaggg ctccagggac   5100
 atccttggaa atacaggagg ctttcctggc acagggcaca gctcttagga ggcctttgta   5160
 ggacgctgtc tccccagcgt gtcctgctca tccaggatgg ggagaaagag gaggaggccc   5220
 caggctcaga agccagggac agactgccga cgattaccaa actgaatcca ggcagtgcca   5280
 tgaccctggg tgtcccttgg ttcacatcac ccaccagaca gctgcggaga gagtgcaggg   5340
 aggggctggg accaaacagg ccagaaacca gcagaaaaga ggcagaagtg aggtgggtgt   5400
 gcctggggca cgaagccagc gccgggggga tttcagtgga gccttacagc caggctccgt   5460
 gcggactgtg atgccagaga ggcgtgcagc ctctgggcaa gtcgggagag ggcttgggtg   5520
 gtccccacaa ggcagaagag gtggaagggc cagagaagac caccaagacc accgttcccg   5580
 caggcctggg gtgagtgacc tgactgagac tagcgggcag agccaagcag ggctaaactc   5640
 caacccaggg cccggtgttg gacaaagtag ctttttcttt gctcgtttgt ctgtgtatta   5700
 agaagagact aaaatagcca aacgacgctg gtcgcatgcg ctggctgtgg tctgtctgct   5760
 gaatgtctat ttttgtctcc tgacgagacg tgaggaccat gcccttgatc cctccgatgg   5820
 accagaaacc cccttccttg caaaaaaaag gcaattgaat taggaaaaga tagaccaacc   5880
 tagctcagat ccaccaagat aagcacagca aagcttggct gcatttttga ggaataaaaa   5940
 cctgcagaaa gcaccgataa ccttcaagat ctgaatgaga ttctattata acccgtctaa   6000
 accgattgca aaattcctcc tttggttttg gaaaacaacg ttgcttctcc cgtggctcgg   6060
 attctctgag gaccagggag ttgacacaca aaccccgcca tgggtccgag ccagctattt   6120
 ctcaaggctc ccacctcgcc aagctcccaa gggcctgctg gcagtgccta cgctgtgcca   6180
 actaccctgt ctggtacaga ccacggctgg gtaagcaccc ttaaaagcaa cagaaatgac   6240
 gtctggaagc tgaaatgtga aactgtcaag atggcttaag gagaggaagg agtggacccg   6300
 ctggtctttg gcattttgta tttagaatta ttctaacttt atacataatg tataggccga   6360
 tcttttggaa gggataaggt tttcattctt gtgcaactca ttattctcat tattggcctt   6420
 ttaaataaaa agttgttttg cagtgtgcct tgagtgcccc gtgaaaactt ctctttaatg   6480
 acctccaggt gtgttcctgc cccacgcact cgggctgaac aaacgatccg cttcaaaaac   6540
 cccgcttctc tgggcttctg gcattttgcc gtggtcgtaa tgcaggcttg gggttggaga   6600
 gccagctgga gggacgggtc ccgccgccag ctccctgcca cgcatgaact cggatacatc   6660
 tgttgacacc ccggtccccc gtcaaatatc tattccctct gcctgttgag tatgggtgta   6720
 tccacggttc cgtccccaac ac                                            6742



      <210> 1449
      <211> 650
      <212> DNA
      <213> Homo sapiens


      <400> 1449
 atggtcaaag agcaggagag tcatctcttg ctcagatttc aggtatctta tccagaaacg     60
 cagggcattt tccctgttct gtcctccatg cccctcttcc ccatgcactg cgctcatgcc    120
 actaataatg cagcgtcaac acagttccac agtacgggga tttccttgac agcggaagcc    180
 actgactgca ccccaacgta tactgatgtc atcagcgaga ccctgtgcag catgaagaag    240
 cggaaagaca acctcaatca gttgtaccag catcattggg ctgaatggaa ttattttgcc    300
 aagcatctaa aggagctgca agacaacttc tccagggaaa tgaagaatat tgatccaaaa    360
 gcagcagata caaaaaaggc aaaccacatg ttcatcccac cttcagccgt caatgaggaa    420
 tcacctgaca agaaaaataa gggaagtctc caaagagaaa ttgagtttaa gggttgttcg    480
 aacaaaaacc atgggaaagg tagaagtgtg aacatgaggg gaaaggagga gagggaaaga    540
 gaagagaaac agaagttgaa catttctttc cactcacttc caagccctga ggagctccac    600
 aacctagaac caggaagcgc ctacagaatc cgtgatattt ctgctacgag               650



      <210> 1450
      <211> 1077
      <212> DNA
      <213> Homo sapiens


      <400> 1450
 atgaaggcac tcagccctgg gcacaggagg cagctcttcc tgcaggcaac aaagacccag     60
 ggatacctgg gtcccagaga ccaccatcct cacagcctgg tcatctcact gcagcagctt    120
 ggtccctggc tgcaggtgac ggtggccggc caagtaaaca ccttggcagg aatccagaaa    180
 acgatccacg cagaacattg caatgtcaca gaaatggccg cccactggcc acgaagccct    240
 ggccccaccc tgcgagcagg gcccacccca ggtgctagac tcaaatgctg tggctccgac    300
 cgcagactgt ggctaccaat tatcaactgc catcaacaga aaccaggagc tctgcggcag    360
 gaagccggcc gtgtcaccga gcagagaata agtccggggt ctccgatcct gagaccagct    420
 gtacacccag ggcactactg tttacagcaa cgtctatcag ggcagaaaag caacagaaga    480
 accacccaga agagtttcca gaagcttcac gtggataaaa ggaaaccaga gaatttcagc    540
 aaggaaagtg accatttatt aatatacagc cgcgagggaa atccggatgt tgcctccctg    600
 gccactcccc ctggtatctg gatgatgtct gccacagacc ttttctatgg ggaccccttt    660
 gcctttccag gagggggacc attcactctg tccctggaga ggggtcctag cgtgatcctc    720
 ggcacagatg cctcagaaga gcttctcttc acaaaggcat ctttagctgt cagcacctcg    780
 gtcttccagt tcagcacagg gaagatctac actgagtggg tgtggcaaaa aaacaagagt    840
 ttcctctctc cccacttccc aacaaagcct atggcatctc cagtgaaagg caagcacagc    900
 acgtccctgt tgcagaggtt aaattacagg gaccgctggc agtgcctgca ggaaggggca    960
 gggctggctc tgctcagtgc ccacatgaag gtgcccacag gctccaaaga accccagcaa   1020
 gcaggcaagt tgcccagcaa gcccagaaaa caaaccacac caactttcaa ggactaa      1077



      <210> 1451
      <211> 391
      <212> DNA
      <213> Homo sapiens


      <400> 1451
 agcagtctcg gctcgcccag gctgggctcc ttgggggtcc cggggactgg gcgagcagtc     60
 tcggctcgtg ccagcggcgg aggaagaaga gctgctgcgg gagatggagg agctgcgctc    120
 ggagaacgac tatctcaagg atgagttaga tgaactccgt gctgagatgg aagagatgag    180
 agacagttat ttagaggaag atgtttacca gctgcaggaa cttcggcgag aactggaccg    240
 cgctaataaa aactgccgaa tcctgcagta ccgtcttcgg aaagccgagc agaaaagcct    300
 gaaagtggct gagacgggtc aggtggatgg tgagcttatt cgaagcctgg agcaggactt    360
 gaaggtagcc aaagatgtat ctgtcagatt g                                   391



      <210> 1452
      <211> 535
      <212> DNA
      <213> Homo sapiens


      <400> 1452
 caattcccgg gtcgacgatt tcgtgtactt ctgttggggc gccgactcca gggagctgca     60
 gcgccggagg acggcgggca gccccggggc tgagctactg caggcggcca gcggggagcg    120
 ccactctctg ctgctgctga ccaaccacag ggtcctctcg tgcggagaca acagcagggg    180
 tcagctgggc cgcaggggcg cgcagcgcgg ggagctgcca caaccaattc aggcattgga    240
 aaccctaatt gttgatctcg tgagctgcgg gaaggagcac tccctggctg tgtgccacaa    300
 aggaagggtc ttcgcatggg gagctggttc tgaagggcag ctggggattg gagaattcaa    360
 ggaaataagt ttcacaccta agaaaataac gactctgaat gatataaaaa taatacaagt    420
 ttcctgtgga cactaccact ccctggcatt atcaaaagat agccaagtgt tttcgtgggg    480
 aaagaacagc catgggcagc tgggcttggg gaaggagttc ccctcccaag ccagg         535



      <210> 1453
      <211> 348
      <212> DNA
      <213> Homo sapiens


      <400> 1453
 gccagatgtg ccccacttct tatcggggaa accggagtaa tgatcaaggc atgtgcttta     60
 aacaccaaga agccctgaaa ctcttctgtg aggtggacaa agaggccatc tgtgtggtgt    120
 gccgagaatc caggagccac aaacagcaca gcgtgctgcc tttggaggag gtggtgcagg    180
 agtaccaggt gagagaaatg agggaatgtg gggggatgaa gggagtggaa aggtaactag    240
 gagagctgag gaatgagtag cattcctttc ccacctcctc aggtacttag ttgctaaact    300
 tctctttatt tgatgaggga gacacggtgg agagagatgg tcatatgg                 348



      <210> 1454
      <211> 3289
      <212> DNA
      <213> Homo sapiens


      <400> 1454
 gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta     60
 ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt    120
 cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc    180
 cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca    240
 acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc    300
 cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg    360
 acatgattac gaatttaata cgactcacta tagggaattt ggccctcgag gccaagaatt    420
 cggcacgagg tttttttttt tttaagtggg acaattaaaa atttaaaaaa taattttaaa    480
 atagaacagc ttagagatag gaaacctaaa tttatttccc aattccttac tgtgccccca    540
 aaaccagggt tcaccaaaag ggctgtcctc ccaacaattt tctgaattct atatattcag    600
 cattaaattc catgataaag ttggaaatcc attcaccatt tgtaatacat attgatgcat    660
 ttaataaaat tgcatgggcc gtatcttttg catttctgta tcctagtatt aagtacagtg    720
 cctaccacag gccaggttct caatacttga ataaatgaca caaaaatagc caggaccagc    780
 aagttttttc tgggtgggct tcatagaatc tctgtacttg ctggaatcac catgaaatcc    840
 atggtcttca gctttgcatt ttcagcaaca tagttatatt gagttatcct caggtgagca    900
 gtgagaccct tgggagcgga ttcatggtag ggtggctttg taatgtgtca ccttggtgag    960
 gctatgtttc ccggaactct cttccagtaa gatgggccac aagagacatt ttgcttgata   1020
 accggagggc ggaagtgaag cagcagcaca ttgtttttac acttggaagg ttggtgctgg   1080
 ggcaccaggc gttgttgcag ttcacacgtt gccatgtatc tgctagatca cctcgttggt   1140
 gtgggcagta gtcaggcctg cagccaggcc tgcagctgct ccaccttccc caggatcatc   1200
 ctttcagctt ctctaattcc tgggccagat gcatatttaa ctctgtgagg aagggcacca   1260
 gcttcttctg caggacaccc acatcatcga agctggaggt ggtgagagac tgacatgggt   1320
 tccaggccat cctcgtgggt tccagctcgt gctcgtgggc tccactgtgt cctcggtctc   1380
 ccacacttta catccatctt cccttcccga gtgcctgccc tgcagacttg aatcctacag   1440
 tctgtagaag cctccagtca actgctttct agctccaggt tttttaaggt ctttggacct   1500
 tggcaaccag actgctgtat ctcggaagcg ggttccaccc aggctgaaaa tctccgtgat   1560
 cacgggtgtg ccagcccctc ctgcctcttc ctctggggcc aatttggagg cagaatcatc   1620
 cttgttctcc tccttgtcct cctctgggtc aggtggctct tgcttcacag aaggcaggcc   1680
 tgggtctact gccttgctag ggcagccagg caccaatacg ggagaagtca ggacagctgt   1740
 gcctggtgtc cactcgtcct gggtatccgc cttctcttgc ttcacctggg gtaaggccac   1800
 aacccaactc atgccagaac actgggcytc ctgcaacagg gcttctgtgg aagctgcaac   1860
 agggcccggc acctgcacag gamtgcttgc gcccttcccg taaaaaacac aaggttcagt   1920
 gcccaggcgg gggcagcaca aagccaccac ctgcttcctg cttcgttgga gcctgggtat   1980
 ggtctggttg ggctgtgcgt gtagccaagg tgggcttcaa ggtagggcca agatggtgcc   2040
 gtcgggcaga gctgggcctc tttcgacgac ggtaaggtgg gggcgatcct gccccatcct   2100
 cagactctga ccagacactg ggcagcagcc gcttcatggc aaactgcagg cattggcgcc   2160
 aacgacactt ctggcgcttc tggttgctgc ccccgaattt gggcttgtcg cagcagaagt   2220
 cgcagcggcc acatccattc cgccgtaggc aggctgcaca ggccccgcac ttgcggttct   2280
 gccggcggtt cgtgtagggc tgtagctcgt cctcgtctac acagtaatag atgaactcgg   2340
 caggtggcga gggggccagg gctctggggt gcggctctgt gggctctggg gactgtgatg   2400
 ggggtggtgg aggcagtggc tgggctccgg ggcgccgcct ggcagccatc ttggagtcac   2460
 agcctccctt gcggcgggca tgtttacccc gtaggcaacg tcgctggaca catttccact   2520
 ggcgcctgag accagggcgg ggagggcgaa ggcagatggg gcaatggcca caatcytctt   2580
 gggtctgaca gccccggcat actccacacc ctcggctctt aaacattctc tgttcccggt   2640
 tgaaggcaat tctctgtgct cgacagtctt tgcacaacgt tttgagccgc tgcctttggg   2700
 tgccatcccc tgagaagctg attccacagt tctcacagca cccaggagca gggaatgaag   2760
 ctggggctgt gtcagtgtca gccttggtct catccctcgg ggcctccttc ctgacctcac   2820
 cactctgggg tccaacctga cgtttccgag tcttggctgg ccttgaaggc ttctttcgct   2880
 tcttgctggc aaccgccacg ggatgggcct tgggggctgg atagcacaag atgccttgtt   2940
 tgaagtcgaa gagggtgaga tcacacgcag ggcccaggta tcgagtcagc tcaactttgc   3000
 ttcggatcct gtctcctgtg gggctctggt aataggtgtc tgagcgtcca caggtggccc   3060
 ctgacttgcg aaagacttcg cggcgcttcc agccagggcc cagggccggg cagtccagcc   3120
 agtcctcagc catggaggcc acaggaagca gcagtagcca gtttggcacc aggccggtat   3180
 cttccgccac tctaggcccg tggacccatg gcgagggtcc ctcctgcacc tcccgcctcg   3240
 ccctcctccc cttcctcctc ctccgcggcc ggggggagta tcacacaaa               3289



      <210> 1455
      <211> 432
      <212> DNA
      <213> Homo sapiens


      <400> 1455
 ggcccctagt ccaaggccct ggccaccctt cacagctgcc accacagagg gaaaggaaac     60
 aatgtcattt aaccttcata gcagctttgg taataggaac agcagcggcc acagcaaaca    120
 tttactgagc caagtccatt aagccctaca tgtgcgttac cggcatggtc tctggattga    180
 tgattcttct gttacttcct actgtggagg ataaggccct ctgtagtgcc ttttaccaaa    240
 gaccaaagct gcatgcccac catgtatcaa gttcagtaac ccccttcttc tagagaatgc    300
 atgtggaccc tgtggggtgg attctgacca ctgagtgttt ccaggttcca cagcagaaag    360
 ccatggcacc acttcatccc catcctgccg gaatgagaat caatgttgtc aataaccacc    420
 aggccgtgta tt                                                        432



      <210> 1456
      <211> 341
      <212> DNA
      <213> Homo sapiens


      <400> 1456
 gtcaccggtg ctgcgaatgt ggccaaaggg gccgtccagg gcggcctgga cactacaaag     60
 tctgtcctga ctggcactaa agatgctgtg tccactgggc tcacaggggc tgtgaacgtg    120
 gccaaaggga ccgtccagac cggcgtagac accaccaaga ctgtcctaac cggcaccaag    180
 gacaccgtct gcagtggggt gaccagtgct gtgaacgtgg ccaaaggggc cgtccagggg    240
 ggcctggaca ccaccaagtc tgtggtcata ggtacaaaag acacgatgtc cactgggctc    300
 acgggggcag cgaatgtggc caaggggtcg acgcggccgc g                        341



      <210> 1457
      <211> 751
      <212> DNA
      <213> Homo sapiens


      <400> 1457
 cggcacgagg cggggagccg ggagcacggt ggagcggtgg agggcgtcac tgggtttcgg     60
 cgtctggcaa gcggttcagc tgtctgctcc ctagcagccg gccttcgggt cgggcgtctc    120
 cgccggctac tgccgcttca gttctcccgg tgtggccacg agtcgggttg cactgctgtg    180
 atccatcctc atctcctaaa gatgcatcct gacttatctc cacacttgca cactgaagaa    240
 tgcaacgtct tgattaactt gcttaaggaa tgtcacaaaa atcacaacat tctgaaattt    300
 tttggttatt gtaatgatgt tgatcgggag ttgagaaaat gcctgaagaa tgagtacgta    360
 gaaaacagga ccaagagcag ggagcatggc attgcaatgc gaaagaaact ttttaatcct    420
 ccagaggaat ccgaaaaata aattgtattt tcactcgatg cccttggctg gagaagaaga    480
 ccgtaaagac gtctgggttg atacctgaaa gaatccgtgt cttatttggt ctccgataat    540
 cctttgaatg gaaaagtgac ctgtgagaga ttgaaccatg gagaaatatg aaaaccgtgg    600
 attctgagta tttgttgggc agggcgttta gatactgtct cccctttacc agcaaacctg    660
 acttcaccat gtttattccc tttgcctaca accagttaat atctgagtaa cttatctcct    720
 tcaataaaat aatttaaata aaaaaaaaaa a                                   751



      <210> 1458
      <211> 537
      <212> DNA
      <213> Homo sapiens


      <400> 1458
 aaaagcggcg cggctcgttc aagatggcgg agctcgacca gttgcctgac gagagctctt     60
 cagcaaaagc ccttgtcagt ttaaaagaag gaagcttatc taacacgtgg aatgaaaagt    120
 acagttcttt acagaaaaca cctgtttgga aaggcaggaa tacaagctct gctgtggaaa    180
 tgcctttcag aaattcaaaa cgaagtcgac ttttttctga tgaagatgat aggcaaataa    240
 atacaaggtc acctaaaaga aaccagaggg ttgcaatggt tccacagaaa tttacagcaa    300
 caatgtcaac accagataag aaagcttcac agaagattgg ttttcgatta cgtaatctgc    360
 tcaagcttcc taaagcacat aaatggtgta tatacgagtg gttctattca aatatagata    420
 aaccactttt tgaaggtgat aatgactttt gtgtatgtct aaaggaatct tttcctaatt    480
 tgaaaacaag aaagttaaca agagtagaat ggggaaaaat tcggcggctt atgggaa       537



      <210> 1459
      <211> 381
      <212> DNA
      <213> Homo sapiens


      <400> 1459
 atgcctgcag gggtgattct gggggacctt tagtcacaag ggatctgaaa gatacgtggt     60
 atctcattgg aattgtaagc tggggagata actgtggtca aaaggacaag cctggagtct    120
 acacacaagt gacttattac cgaaactgga ttgcttcaaa aacaggcatc taattcacga    180
 taaaagttaa acaaagaaag ctgtatgcag gtcatatatg catgagaatt caactattta    240
 gtgggtgtag tacaacaaag tgatattaaa ttactggatc tagtaacatg aaaaaaaaaa    300
 aaaagggggg gcccgtttaa aagaaacaaa tttaacggcc gggggctggc aaggtaatat    360
 tttttttttg gggcccctaa a                                              381



      <210> 1460
      <211> 381
      <212> DNA
      <213> Homo sapiens


      <400> 1460
 atgcctgcag gggtgattct gggggacctt tagtcacaag ggatctgaaa gatacgtggt     60
 atctcattgg aattgtaagc tggggagata actgtggtca aaaggacaag cctggagtct    120
 acacacaagt gacttattac cgaaactgga ttgcttcaaa aacaggcatc taattcacga    180
 taaaagttaa acaaagaaag ctgtatgcag gtcatatatg catgagaatt caactattta    240
 gtgggtgtag tacaacaaag tgatattaaa ttactggatc tagtaacatg aaaaaaaaaa    300
 aaaagggggg gcccgtttaa aagaaacaaa tttaacggcc gggggctggc aaggtaatat    360
 tttttttttg gggcccctaa a                                              381



      <210> 1461
      <211> 1045
      <212> DNA
      <213> Homo sapiens


      <400> 1461
 tttcgtgccc gctttgactt agagccctcc gcatatcctt cccctggctg gagcagccaa     60
 ggcgcggagg acagctccga ggccagatgt ttactgcgca gatgcccgac tttacaccgg    120
 ggtccgggct gtgccgggcg ctgggggaag cgcccacctt ccagagagcg aaatcatgga    180
 gccttccaag accttcatga gaaacctgcc aatcacacca ggctatagcg gctttgtgcc    240
 attcctcagc tgccaaggaa tgtccaagga ggatgacatg aaccactgtg tgaaaacctt    300
 ccaggagaaa acacagcgct ataaagaaca gctgcgggaa ttgtgctgcg cagtggccac    360
 tgccccgaaa ctgaaacctg tcaactccga ggagacggtc ctgcaggccc tgcaccagta    420
 caatctgcag taccaccccc tgatcctggg tagcagcgcc ctgaaaccat ttcccctcac    480
 ccctgaatgc aaatatgtaa agaaacctct ccaggagccc ccgatccctg gctgggcagg    540
 ctacctgccg agagccaagg tcactgaatt tggctgtggc acgagataca ctgtcatggc    600
 caaaaactgc tacaaggact tcctggagat cacggagagg gccaagaagg cacatctgaa    660
 accatatgaa gaaatatatg gagttagctc cacaaaaact tctgctccgt ctccaaaagt    720
 tttgcagcat gaagagctgc tgccaaaata tcccgatttt tctattccag atgatcacac    780
 tagctcccca gcaatggttc ttaaccagat tgaaatggct gaaatgtcag acatagaatt    840
 cagaatctgg atggcaagaa agctcaatga gacacaagag aaggttgaaa cccaatccaa    900
 ggaaaacaat aaaatgatcc aagggttgaa agatgacatc accattttaa gaaagaacca    960
 aaatgaactt ctggaaatag aaaatttaca ggaatttcat aatacaattg gaagcattaa   1020
 caacaattgg aatagaccaa cctga                                         1045



      <210> 1462
      <211> 419
      <212> DNA
      <213> Homo sapiens


      <400> 1462
 agttttcgaa acactacaac atccacaagg atactgcagt agattacaac gtgtttttga     60
 agaatctcag cataaataac gacttgaacc ttagatattg tatgggaaat caagaggtct    120
 cattggagaa tcaacaagcc aaaaattcca aaaaggaacg tttgctaggt tctgcatcat    180
 ctgaagatat ctggagaaac tactccttgg atgaaattga gaggaacttt tgtctacaag    240
 taagatgttt tcctaagcca caattaccta cagagtaaac acagcaaagt agacaatatg    300
 gaaaactatt aggtttacac attatttcta aaatttgttt cgatcctacc tatgtcttct    360
 ccaatactga gaccccctct acctcccaat aacagcaata cattgatcat ggataaaaa     419



      <210> 1463
      <211> 2148
      <212> DNA
      <213> Homo sapiens


      <400> 1463
 cgaaaagaaa gtgggggact ctaaagattt tctcctttta agaaaaaata gttccggctg     60
 gggagtacaa aatggagtgt aaaaagggcc ttgggcccca gggaggcccc tgtggactaa    120
 ggggagttca tgcacccctt ctttccccag aggggctgga ctcaggtgag tatgggggtg    180
 ggggctcctg cacttcgaca caggcagcgg aagggttttc tccccattcc ctctgcactc    240
 ccaacttgag ctatactttt taagaaagtg attcaccctg cctttgcccc cttccccaga    300
 acagaacacg ttgatcatgg gcgatatttt tcattgtgcc aaaaagttgc catgaccgtc    360
 attaaacctg tttaacacca aataataagg aaaataaaac aaaaagttcg ggcatggtgc    420
 agaaactcac tccaaataaa ttacctacca aaatatataa tggtggaaat attccaaaat    480
 tccatatttt gggatttata cacaaaagat aaacaaatta gaggccaaga ggctgccgga    540
 agggaaaaac ggggcctgga atggccgacg tgaggaatga gctgggccta aagaggccac    600
 tggcaggcag tagctggacc tgccgaagtg gccgaaaggc aggagctttg gacgggggag    660
 gccgcagtga ggcgagagct agctgggcgt ggagagtcca ctgtgaggcc aaggccaagg    720
 ccgggcccgt gcaggccttt gagaggcagg aggccgggcc tgcaaaggcc gactggagat    780
 caagttctgc gcctgaagag gctgccaaaa gtcaaaagcg ggggcctggg aaggcagccg    840
 agagccatga gctgggctgg gccgaaagag gccactggga ggcaggagga gctgggcctg    900
 gagaggctca ctcgaggaag ttttgcacct ggagaggccg ccgagaggac ggagctgggc    960
 ccggggaggc cgacttgctg ctcttccagg cccaattcca ggccgacttg aggacgactt   1020
 gggcctgcag agactgccgg gaggctggag ctgggcctgg agaggccgac ttcgggacga   1080
 tttggacctg cagaggccgc cgggaggccc aagctgggcc tagaggagcc caccgaccgg   1140
 aggccgtttg gggcctgcag atgccatcgg agggcaggag ctgagcctgg agaggccacc   1200
 gtgaggcctg agctgggcct ggggagcttg gctttgggaa gctgtgggcc taccagggcc   1260
 actgggagct gggcaggagc tgagtccaaa gatgttgttg ggaggccaaa gtcgggcctg   1320
 gagacgcagc cgggaggaag agctgggccc ggagaggatg ccgggaggct gcaagtgggt   1380
 ctggagaggc cgacttgagg aggttctggg cccggagagg ccgccggaag ggaaaaactg   1440
 ggcctggaaa ggccgttgtg aggaatgagc cccatgggcc tgaagaggcc actggcaggc   1500
 gggagctggg cctgccgaag cggccgagag gcaggagctt tggactgggg aggccgcagt   1560
 gaggcgagag ctagctgggc gtggagagtc tgctgtgagg cagaggctgg gcctgtgcag   1620
 gccttcggga ggcaggaggc cgggccttgt cgaggcctgc agaggccgcc aaaagtcaaa   1680
 agcggggcct gggaagcccg cccagaggca tgagctgggc tgggccgaaa gaggccactg   1740
 ggaggcagga ggagctgggc ctggagaggc tgactcgagg aagttttgca cctggagagg   1800
 ccgccgagag gacggagctg ggcccgggga ggccgacttg ctgctcttcc aggcccactt   1860
 ccaggccgac ttgaggacga cttgggcctg cagaggctgc cgggaggcca gagctgggcc   1920
 tggagaggcc gacttcggga cgatttgggc ctgcagaggc caccgggagg cccaagctgg   1980
 gcctagagaa gcccaccgac cggaggccgt ttggggcctg cagatgccat cggagggcag   2040
 gagctgagcc tggagaggcc accgtgaggc ctgagctggg cctggggagc ttggctaggg   2100
 aagtttgtgg gcctaccagg gcctctggga gctgggcagg agctgagt                2148



      <210> 1464
      <211> 632
      <212> DNA
      <213> Homo sapiens


      <400> 1464
 ttccgggtcg acccacgcgt ccgcccacgc gttcggtttg tggctttttt ggccaaggag     60
 cagaaggaag attacttgcc tgttctcagg gtggtcagtg ttaccatcca tactgtgtca    120
 gtattaagat cactaaagtg gttcttagca aaggttggag gtgtcttgag tgcactgtgt    180
 gtgaggcctg tgggaaggca actgacccag gaagactcct gctgtgtgat gactgtgaca    240
 taagttatca cacctactgc ctagaccctc cattgcagac agttcccaaa ggaggctgga    300
 agtgcaaatg gtgtgtttgg tgcagacact gtggagcaac atctgcaggt ctaagatgtg    360
 aatggcagaa caattacaca cagtgcgctc cttgtgcaag cttatcttcc tgtccagtct    420
 gctatcgaaa ctatagagaa gaagatctta ttctgcaatg tagacaatgt gatagatgga    480
 tgcatgcagt ttgtcagaac ttaaatactg aggaagaagt ggaaaatgta gcacacattg    540
 gttttgattg tagcatgtgc agaccctata tgcctgcgtc taatgtgcct tcctcagact    600
 gctgtgaatc ttcacttgta gcacaaattg tc                                  632



      <210> 1465
      <211> 632
      <212> DNA
      <213> Homo sapiens


      <400> 1465
 ttccgggtcg acccacgcgt ccgcccacgc gttcggtttg tggctttttt ggccaaggag     60
 cagaaggaag attacttgcc tgttctcagg gtggtcagtg ttaccatcca tactgtgtca    120
 gtattaagat cactaaagtg gttcttagca aaggttggag gtgtcttgag tgcactgtgt    180
 gtgaggcctg tgggaaggca actgacccag gaagactcct gctgtgtgat gactgtgaca    240
 taagttatca cacctactgc ctagaccctc cattgcagac agttcccaaa ggaggctgga    300
 agtgcaaatg gtgtgtttgg tgcagacact gtggagcaac atctgcaggt ctaagatgtg    360
 aatggcagaa caattacaca cagtgcgctc cttgtgcaag cttatcttcc tgtccagtct    420
 gctatcgaaa ctatagagaa gaagatctta ttctgcaatg tagacaatgt gatagatgga    480
 tgcatgcagt ttgtcagaac ttaaatactg aggaagaagt ggaaaatgta gcacacattg    540
 gttttgattg tagcatgtgc agaccctata tgcctgcgtc taatgtgcct tcctcagact    600
 gctgtgaatc ttcacttgta gcacaaattg tc                                  632



      <210> 1466
      <211> 712
      <212> DNA
      <213> Homo sapiens


      <400> 1466
 acagacatgg ttccagctct gtagaactga gagaaagaat aaacaagtca cacattagcc     60
 cttcaaaaag atgaccgacc tcttgagaag tgttgtcacc gtaattgatg ttttctacaa    120
 atacaccaag caagatgggg agtgtggcac actgagcaag ggtgaactaa aggaacttct    180
 ggagaaagag cttcatccag ttctgaagaa cccagatgat ccagacacag tggatgtcat    240
 catgcatatg ctggatcgag atcatgacag aagattggac tttactgagt ttcttttgat    300
 gatattcaag ctgactatgg cctgcaacaa ggtcctcagc aaagaatact gcaaagcttc    360
 agggtcaaag aagcataggc gtggtcaccg acaccaagaa gaagaaagtg aaacagaaga    420
 ggatgaagag gatacaccag gacataaatc aggttacaga cattcaagtt ggagtgaggg    480
 agaggagcat ggatatagtt ctgggcactc aaggggaact gtgaaatgta gacatgggtc    540
 caactccagg aggctaggaa gacaaggtaa tttatccagc tctgggaacc aagagggatc    600
 tcagaaaaga taccacaggt ccagctgtgg tcattcatgg agtggtggca aagacagaca    660
 tggttccagc tctgtagaac tgagagaaag aataaacaag tcacacatta aa            712



      <210> 1467
      <211> 410
      <212> DNA
      <213> Homo sapiens


      <400> 1467
 aggagatctg tggcatccag cagcgtctgg ccctgcctgt gtggcggccc cgggactttg     60
 aagaggagct ggccgactgc acagccgagc tgggtgagac agtcaagctg gcctgccgcg    120
 tgacgggcac acccaagcct gtcatcagct ggtacaaaga tgggaaagca gtgcaggtgg    180
 acccccacca catcctcatt gaagaccctg atggctcgtg tgcactcatc ctggacagcc    240
 tgaccggtgt ggactctggc cagtacatgt gcttcgcggc cagcgccgct ggcaactgca    300
 gtaccctggg caagatcctg gtgcaagtcc caccacggtt cgtgaacaag gtccgggcct    360
 caccctttgt ggagggagag gacgcccagt tcacctgcac catcgaaggg               410



      <210> 1468
      <211> 367
      <212> DNA
      <213> Homo sapiens


      <400> 1468
 ggaatgaggt tgtcggaatt agctaagagc cgttaacgat ccagcacctg gagccagcag     60
 catggccgcc ctcacagatg ggcagccagt taggtggcga gagggagacc ggtagatgaa    120
 tgctgtcggc ctcaggcaca gtgccccgtc tcaccttcct gcactcacga actccgttgt    180
 gccccaaccc aggaggtgga tgcgtctgag atccaggtgc aggtgtgttt gtacgccttc    240
 gacctcatct acctcaatgg agaggtgagt tccagcttcc tgcccctctg acttccattt    300
 ccgactctgc cacttcacat ggccaggaag ccacacttgg gcagcagttc tcaaagtgtg    360
 gtctgag                                                              367



      <210> 1469
      <211> 1520
      <212> DNA
      <213> Homo sapiens


      <400> 1469
 atggaggagc ttttaggaac tgtatttgtg atctggtggc tttggcctgg cagctacggc     60
 accagtgcag ctgatactca aggttcagat cagaagagga ggcttctcac cctgcagcag    120
 ggacctgtga gcatggcatg ccctggcttc ctgtgggcac ttgtgatctc cacctgtctt    180
 gaatttagca tggctcagac agtcactcag tctcaaccag agatgtctgt gcaggaggca    240
 gagaccgtga ccctgagctg cacatatgac accagtgaga gtgattatta tttattctgg    300
 tacaagcagc ctcccagcag gcagatgatt ctcgttattc gccaagaagc ttataagcaa    360
 cagaatgcaa cagagaatcg tttctctgtg aacttccaga aagcagccaa atccttcagt    420
 ctcaagatct cagactcaca gctgggggat gccgcgatgt atttctgtgc ttataggagc    480
 ggaagagatg acaagatcat ctttggaaaa gggacacgac ttcatattct ccccaatatc    540
 cagaaccctg accctgccgt gtaccagctg agagactcta aatccagtga caagtctgtc    600
 tgcctattca ccgattttga ttctcaaaca aatgtgtcac aaagtaagga ttctgatgtg    660
 tatatcacag acaaaactgt gctagacatg aggtctatgg acttcaagag caacagtgct    720
 gtggcctgga gcaacaaatc tgactttgca tgtgcaaacg ccttcaacaa cagcattatt    780
 ccagaagaca ccttcttccc cagcccagaa agttcctgtg atgtcaagct ggtcgagaaa    840
 agctttgaaa cagatacgaa cctaaacttt caaaacctgt cagtgattgg gttccgaatc    900
 ctcctcctga aagtggccgg gtttaatctg ctcatgacgc tgcggctgtg gtccagctga    960
 gatctgcaag attgtaagac agcctgtgct ccctcgctcc ttcctctgca ttgcccctct   1020
 tctccctctc caaacagagg gaactctcct acccccaagg aggtgaaagc tgctaccacc   1080
 tctgtgcccc cccggcaatg ccaccaactg gatcctaccc gaatttatga ttaagattgc   1140
 tgaagagctg ccaaacactg ctgccacccc ctctgttccc ttattgctgc ttgtcactgc   1200
 ctgacattca cggcagaggc aaggctgctg cagcctcccc tggctgtgca cattccctcc   1260
 tgctccccag agactgcctc cgccatccca cagatgatgg atcttcagtg ggttctcttg   1320
 ggctctaggt cctggagaat gttgtgaggg gtttattttt ttttaatagt gttcataaag   1380
 aaatacatag tattcttctt ctcaagacgt ggggggaaat tatctcatta tcgaggccct   1440
 gctatgctgt gtgtctgggc gtgttgtatg tcctgctgcc gatgccttca ttaaaatgat   1500
 ttggaagagc aaaaaaaaaa                                               1520



      <210> 1470
      <211> 1681
      <212> DNA
      <213> Homo sapiens


      <400> 1470
 atcagagcat tagatcttgc tggagatcct acaagctata agactttgca gaaatgtcct     60
 tctacagaac cagaagaaaa aggaaatatc gtggaagaac agccccagaa aaataccacg    120
 gagaaattgg gtgtgtcagc tcccaccata cccgttagaa ggcggctggc ttgggataca    180
 gagaacacaa gtgaagacgt acagaaacag cccggggaga aagaggagga ggacgacaat    240
 gaagaggaag gggacaggaa aacgggcaag caggctttta tgggagagca agagaagttg    300
 gatgtacatg agaaatctaa ggcagataag atgaaagaag ggtcagattc ttctgtatcc    360
 tcagaaaaag gaggccggct tcctactccc aagctgagag aacttggtgg aatccagagg    420
 actcatcatg atctcactac tccagctgtt ggtggtgctg ttttagtgtc tccatctaag    480
 atgaagcctc cagccccaga acagaggaaa agaatgacct ctcaggattg tttagaaact    540
 tcaaagaatg attttactaa gaaagaaagt cgtgctgtat ccctactgac ttctccagct    600
 gctggtataa aaacagttga tcctctgcct ttgcgggaag attctgaaga caatatccac    660
 aaatttgctg aggcaactct tccagtttca aaaattccaa aatacccaac aaatccccct    720
 ggacagttgc cttctccacc acatgttcca tcctactggc atccctctcg acgaattcag    780
 ggctctctta gagatccaga gtttcagcac aatgtgggaa aagcaaggat gaacaatttg    840
 cagttacctc aacatgaagc ctttaatgat gaagatgagg acagattgtc tgagatttct    900
 gctcgctctg cagcttctag tctccgggct tttcaaactc tggcacgagc taagaaaagg    960
 aaggagaatt tctggggtaa aacataaacc tagctgagtt gcctttatct aaggaaacat   1020
 tggcataatt tttctttatt gcttactgtg ttaaaatttt ttgagtgaag tttttcctaa   1080
 cattttctac tttgaaatat ttaatttcca atagaacagt ttacttggaa attgttaaca   1140
 taggcttata caaatttaac ttttaaagaa ttctttttac atctatccca gagtacaaag   1200
 acctagatta ttgaattctt cacatgtaac tttcgtaata ggtgtcatgg atagattttc   1260
 acctatccag agagtattct aaaaaaataa acaaagtgaa gtaaaagtta agatcccagt   1320
 gtgaagtata tattccccta agatttgata tatgtatctt tataattgat gatgttgaaa   1380
 atgaatttgg tggtcccctt aacccttgcc tgtagtgttt ctttttattt tagttccctt   1440
 cctatacatg tttgccagtg ttaagataat tgtactttga aaacacccag ctgtatatat   1500
 ttttccttat ttatgtaacg aaagtttgct gaaagatatg tatatttttg atctttgagt   1560
 gtattctatt tgtgtaagga ctttggctta catttgaata atgtctagat tttgaaaaat   1620
 tacctgtata atggagaatt aaaactttgt agacattttg aaataaaaat ggatcaagtg   1680
 c                                                                   1681



      <210> 1471
      <211> 415
      <212> DNA
      <213> Homo sapiens


      <400> 1471
 gctgagcttt tgctcgccgt ccaccactgc tgtttgtcgc tgtcgcagac ccgctgctga     60
 ctgccatccg tctggatccg gcagggtgtc cactgtgctc ctgatccaat gaggcaccca    120
 ttgccgctcc cgatccggct aaaggcttgc cattgttcct gcacagctag gtgcccgggt    180
 ttgtcctaat ccagctgaac gctagtcact gggttccacg gttctcttcc gtgatccacg    240
 gcttctaata gagcgataac actcaccaca tggcccaaga ttccattcct tggaatccat    300
 gaggccaaga accccaggtc agagaacaca aggcttgcca ccatcttgga agcggcccgc    360
 caccatcttg ggagctctgg gagcaaggac cccccgaccc aataagagtt tcgca         415



      <210> 1472
      <211> 886
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(886)
      <223> n = a,t,c or g


      <400> 1472
 tttttatttt tttgcttttt aaaagttttt atttcaaaaa ataaagctgc agttcatttc     60
 acataaatat ctggggaggg aaggggagtg ggatggggtg ggggcttggc ccctacctcc    120
 tcttctcttt cacactgtat tgtaaaagca aaggggatgg cttgccgaac cagcgggaga    180
 gccatatctg cttcattgtc atgtgatcag ggagaacttc attgtcaaaa aggagctgca    240
 catgctgagg gtttagcatc aagcggtgac acaggaccct ccggagatgg cgtacctcag    300
 ctctaacaga acatcggaca tacttgttct gcaggacgct tttattcttg tctttgccag    360
 aactcagccg ctccaggcac aggttcaact gctcatcata gcgatagtag tgggctttag    420
 agtggtcaaa gctgctgaag gggaggccga ggttgctcag tgctggctct tccccagtgg    480
 gctgggtgac ccggtccaaa cctcgggact ggtagaattc ccgaatccgt ttctcttcac    540
 tgtcttgcaa gccaggcacc agcttataca cgatgtcctg catgacccgg tccagtttga    600
 ggttgagcag tggctgtgtc tcgtggatct taatgttgca catggggcag tacttgctag    660
 tttggaggta cttcacaata caactcttgc agaaagtatg aagacactct gtgatggtgg    720
 tggcatccac gaagtagccg gcgcataggc agcaaacaat gtgttcattc aagtctttga    780
 tcttcactcg aacctcctcc tgaccctcct ttcccagggg agactacaca acgtcggcga    840
 cacaacgcgc aggcggaatt ccaccgcntg gactaatgtc tacaat                   886



      <210> 1473
      <211> 1214
      <212> DNA
      <213> Homo sapiens


      <400> 1473
 tttttttttt ttgacagtaa gagcaggttt actgttggca acagcacagc cctgtggcac     60
 ccaagggtag cgggtggggt ggcggccggg tctcctgggg ccccgttctc cctcccattc    120
 tctaggtccc tggaggccag acccctgggt gcggcccatc ctagcagtgg ttctggctgg    180
 gtctgtcctg ggcaggagag gagggtccct ggagaggcag tgatggctac agcgtctgta    240
 gggagctggg gacacttccg gccagccatg acaggcccaa gcctgctcag ctctgcactt    300
 ctggggatcc ccttattcct gactctcccc cctcccccac ctggaagaga cctaggccct    360
 gcaccctaat gaggaggacc ggggtgaggg ggtgcagagt gtcctggggg ggctccgagc    420
 gcttggcagg ggactcagca aggggagcgt agggcgggcc tcacgtctgc agctccagga    480
 ggcagttggg ctctgagggt ggggagccgg ccgggctgga gctatgggcc tcgcggaggt    540
 cctgcagcac ccggagcagc cgggccaatg agtcctcggg gactttgcca gggctcgtgg    600
 gcaccgtgcc tgcctctgcg cccccgctca gctcccggtg cctctcccac agcatggcct    660
 ccacgcccag caggtgccgg tagatgagct gggcctcaag gtcatggtca agagggtcat    720
 tccactcctg cagggtcacc cgtgaccggg tcttatcgca gccctgacct gtcttctctt    780
 tttggtggca gcagctccac ttgtccccac ggaagacgcc agggtggtag gagcccagca    840
 gtccggtgtt gttgatgctc accttccgca gcgcagacag ccactggtta agctcattca    900
 cacacttgga gctgggcgtc ttcgcgaagc tgagggcctc ggtagtgagg gagaagtaga    960
 gcttcttgaa ggaggaggac atgagggggc ccttgccctt ggtcctgtgg atgaagagtg   1020
 gcccctcctt cacaggtggc gcctgcaaac tcagcgtccg ctgcaggtcc agctctgcca   1080
 ggccagggag ggaggggaat agagagccca gtgaatgagg gcgggactgg ggggagcgga   1140
 gcagtgggag gggccatggg gctcaagggc tgagcaaatc tgaacagcag gcagtggacg   1200
 tagtcactcg tgcc                                                     1214



      <210> 1474
      <211> 778
      <212> DNA
      <213> Homo sapiens


      <400> 1474
 tttcgtagga tgcccagcca gccgagctcc gggcagtacc cgccctccac ggtcaacatg     60
 gggcagtatt acaagccaga acagtttaat ggacaaaata acacgttctc gggaagcagc    120
 tacagtaact acagccaggg gaatgtcaac aggcctccca ggccggttgc tgtggcaaat    180
 tacccccact cacctgttcc agggaacccc acacccccca tgacccctgg gagcagcatc    240
 cctccatacc tgtcccccag ccaagacgtc aaaccaccct tcccgcctga catcaagcca    300
 aatatgagcg ctctgccacc acccccagcc aaccacaatg acgagctgcg gctcacattc    360
 cctgtgcggg atggcgtggt gctggagccc ttccgcctgg agcacaacct ggcggtcagc    420
 aaccatgtgt tccacctgcg gcccacggtc caccagacgc tgatgtggag gtctgacctg    480
 gagctgcagt tcaagtgcta ccaccacgag gaccggcaga tgaacaccaa ctggcccgcc    540
 tcggtgcagg tcagcgtgaa cgccacgccc ctcaccattg agcgcggcga caacaagacc    600
 tcccacaagc ccctgcacct gaagcacgtg tgccagccgg gccgcaacac catccagatc    660
 accgtcacgg cctgctgctg ctcccacctc ttcgtgctgc agctggtaca ccggccctcc    720
 gtccgctctg tgctgcaagg actcctcaag aagcgcctcc tgcccgcaga gcactgta      778



      <210> 1475
      <211> 1806
      <212> DNA
      <213> Homo sapiens


      <400> 1475
 cccccgcttg gcttccagcg ccgcttgcgc tccggagcgc tggctctgct ggcgctgaga     60
 aatggaccaa ttttgacaag atatagtgct gcagcgtgcc tgatgggata tattcagtca    120
 tggcgtccga actttgtaag acgatctctg tggcaaggct agaaaagcac aagaatttgt    180
 tcttaaatta taggaatctg caccattttc cattggagtt actgaaagat gagggactgc    240
 agtacttgga gagactctat atgaaaagga actccctgac atccttgcca gaaaaccttg    300
 ctcagaagct tccaaacctt gtggaactat acctgcactc aaataacata gttgtggttc    360
 cggaagccat tgggtctctt gtaaaactcc aatgtctgga tcttagtgac aatgccttag    420
 aaattgtttg cccagaaatt ggtcgtctga gagctttacg tcatcttcga ttagctaata    480
 accaactgca attcctacct ccagaggttg gcgatttgaa ggagctgcag acactagaca    540
 tttctaccaa tcgtttgcta actttacccg agaggcttca catgtgcctt tctctgcagt    600
 acctcactgt ggaccgaaat cgtctatggt atgtgccgcg ccatctctgc cagctgccca    660
 gcctcaatga gctctccatg gctggaaacc gtcttgcatt tttgccactt gatttaggtc    720
 gatctcgaga actacagtat gtatacgtgg ataacaacat tcacctgaaa ggcttgccat    780
 cttatctgta caataaagtc atcgggtgca gtggctgtgg tgctcccatt caagtttccg    840
 aggtgaagct gctttccttt tcatcagggc agcgaaccgt tttcctccca gctgaggtga    900
 aggccatagg gacggagcat gatcacgtcc tccctctgca ggaattggct atgagagggc    960
 tgtatcatac ctaccacagc ttgctgaaag atttgaactt tctgtctcca atctcattac   1020
 ccagaagtct cctagagctg ctgcactgcc ctctggggca ctgtcatcgg tgtagtgagc   1080
 ctatgtttac catcgtctac cccaagctct ttcccttgag agagacgcca atggcagggc   1140
 tgcaccagtg gaagacaact gttagttttg tggcttactg ctgctccacc cagtgtctgc   1200
 agacttttga cctgctgagt tgataaacac tcaagaacct caggagcgct gccagcttga   1260
 cactggggaa tccagccagt ccagcacact cttccatcct gtcctgtcca atgcgggggc   1320
 actgcagaac tctctagaaa tgtcatgatt gagcttcaga gctaaaatgc cttcaccctt   1380
 cccccaagtt ggaatatatc ctcccccaaa ttaaggaccc atttgtcttc tgtgtttttc   1440
 ctttttatgt gagtgtgtct tttacagaaa ccatttagat tgatgggcct ccccaaatct   1500
 aatttaaagc aagtttccgg tccttggaga acagtgactt gatcatctag ccagattccc   1560
 ttttgaacac acataccttc agtgatgctt cctctcctct cccctccctt gctttcccca   1620
 gagagttatt tccctgagac catgttctcc acagtgtctc cagtggaaac ttgtcagttt   1680
 ttgaggagtt tcagcaaacc ccgtggcctc aaatggtctt gaagtagcag ggtggggcgc   1740
 ctgagttggc aagcaaagtg aggctcccat ggaggctcag tgagggtccc agagcacaca   1800
 ccctct                                                              1806



      <210> 1476
      <211> 377
      <212> DNA
      <213> Homo sapiens


      <400> 1476
 gcaagggata gcattgctga ccagaatggg cgagtcagtc aagcacgtca ctggcggcta     60
 caagctgagg actcggccgc ttgagtttgc tgccataggt gactacttag atacatttgc    120
 actcaaactg ggaaccattg atcgaatagc ccagcggatc atcaaagaag aaatagagta    180
 ccttgtggag ctgagagaat acgggcctgt gtactccaca tggagcgcct tggagggtga    240
 gctggctgaa cccctggagg gtgtgtcagc ttgcattggg aactgctcta cagccttata    300
 agagctgaca gatgacatga cagaagactt cctatttgtg ctcagggaat atattttata    360
 ctctgactcc atgaagg                                                   377



      <210> 1477
      <211> 1910
      <212> DNA
      <213> Homo sapiens


      <400> 1477
 cggccgcgta gcccgcgcgc ggagcgtacc ctgctgcggc cgttggccgt tagcgcggct     60
 tcggcggttg tcttggagaa gcaagatggc ggcgacggcg gccgcagtgg tggccgagga    120
 ggacacggag ctgcgggacc tgctggtgca gacgctggag aacagcgggg tcctgaaccg    180
 catcaaggct gaactccgag cagctgtgtt tttagcacta gaggagcaag aaaaagtaga    240
 gaacaaaact cctttagtta atgagagcct gaaaaagttt ttaaatacca aagacggtcg    300
 tttagtggct agtcttgttg cagaatttct tcagtttttt aaccttgact ttactttggc    360
 tgtttttcaa cctgaaacta gcacatattt taacttcttt tctagctgca aggtctcgaa    420
 ggtcgagaga atttagcccg agatttaggt ataattgaag cagaaggtac tgtgggtgga    480
 cccttattat tagaagtgat caggcgctgt caacagaaag aaaaagggcc aaccactggg    540
 gaaggtgcac ttgatctatc tgatgtacat tctccaccaa agtcaccaga gggaaaaaca    600
 agtgcacaga caacaccaag taagatacca aggtataaag gacaaggtaa gaagaagaca    660
 agcgggcaga aggctggtga caagaaggcc aatgatgagg ccaatcagag tgatacaagt    720
 gtctccttgt cagaacccaa gagcaaaagc agccttcact tactgtccca tgaaacaaaa    780
 attgtatctt ttctaagcaa cagaacttta gatggcaaag acaaagctgg cctttgtcca    840
 gatgaagatg atatggaagg agattctttc tttgatgatc ccattcctaa gccagagaaa    900
 acttacggtt tgaggaagga acctaggaag caagcaggaa gtctggcctc gctctcggat    960
 gcacccccct taaaaagtgg actcagctcc ctggcgggag ccccttcttt aaaagactct   1020
 gagagtaaaa ggggaaatac agttttgaaa gatctgaaat tgatcagtga taaaattgga   1080
 tcacttggat taggaactgg agaagatgat gactatgttg atgattttaa tagtaccagc   1140
 catcgctcag agaaaagtga gataagtatt ggtgaagaga tagaagaaga cctttctgtg   1200
 gaaatagatg acatcaatac cagtgataag cttgatgacc tcacacaaga tctgactgta   1260
 tcccagctca gtgatgttgc ggattatctg gaagatgttg catagacacg aagaaggaag   1320
 tattctaatt aacaaggaca gaggactgac cggttccatt tttttttttt tccaaacaat   1380
 cactcagctg gaagggcggc tctctattgg ggccttgcat ttcaaaaacc ctgcagattt   1440
 tttttaaaag aaattttcat tttactaaac aaaatacttc ctatttgagc ccatgggggg   1500
 aaaatttaat attcttaatt taactgtaca tttctttatg gaaatggatt atctacactc   1560
 agtttcatta cagggaagga acccatgaaa acatcagtgt taagagcatg atgaaaggtg   1620
 tcaataaagc cgtaggatcg cgcaaccctt tgtgtgtgtg gctgctggta cgtgtgatct   1680
 ttgaaaacct tggctttagc cctctggaat cagagcttac ccaccatagt atattttgat   1740
 attaggtggt tctacacata gttggcaaaa tgacttggta aatttgtaat gctgaagtat   1800
 attagtataa gttaaatttg atgtgtcaac tttattttgt atttccttcc atttggaagg   1860
 tttgttagac cattaaggtt atattaaagt actcttgtgt gtgctaaaaa              1910



      <210> 1478
      <211> 1910
      <212> DNA
      <213> Homo sapiens


      <400> 1478
 cggccgcgta gcccgcgcgc ggagcgtacc ctgctgcggc cgttggccgt tagcgcggct     60
 tcggcggttg tcttggagaa gcaagatggc ggcgacggcg gccgcagtgg tggccgagga    120
 ggacacggag ctgcgggacc tgctggtgca gacgctggag aacagcgggg tcctgaaccg    180
 catcaaggct gaactccgag cagctgtgtt tttagcacta gaggagcaag aaaaagtaga    240
 gaacaaaact cctttagtta atgagagcct gaaaaagttt ttaaatacca aagacggtcg    300
 tttagtggct agtcttgttg cagaatttct tcagtttttt aaccttgact ttactttggc    360
 tgtttttcaa cctgaaacta gcacatattt taacttcttt tctagctgca aggtctcgaa    420
 ggtcgagaga atttagcccg agatttaggt ataattgaag cagaaggtac tgtgggtgga    480
 cccttattat tagaagtgat caggcgctgt caacagaaag aaaaagggcc aaccactggg    540
 gaaggtgcac ttgatctatc tgatgtacat tctccaccaa agtcaccaga gggaaaaaca    600
 agtgcacaga caacaccaag taagatacca aggtataaag gacaaggtaa gaagaagaca    660
 agcgggcaga aggctggtga caagaaggcc aatgatgagg ccaatcagag tgatacaagt    720
 gtctccttgt cagaacccaa gagcaaaagc agccttcact tactgtccca tgaaacaaaa    780
 attgtatctt ttctaagcaa cagaacttta gatggcaaag acaaagctgg cctttgtcca    840
 gatgaagatg atatggaagg agattctttc tttgatgatc ccattcctaa gccagagaaa    900
 acttacggtt tgaggaagga acctaggaag caagcaggaa gtctggcctc gctctcggat    960
 gcacccccct taaaaagtgg actcagctcc ctggcgggag ccccttcttt aaaagactct   1020
 gagagtaaaa ggggaaatac agttttgaaa gatctgaaat tgatcagtga taaaattgga   1080
 tcacttggat taggaactgg agaagatgat gactatgttg atgattttaa tagtaccagc   1140
 catcgctcag agaaaagtga gataagtatt ggtgaagaga tagaagaaga cctttctgtg   1200
 gaaatagatg acatcaatac cagtgataag cttgatgacc tcacacaaga tctgactgta   1260
 tcccagctca gtgatgttgc ggattatctg gaagatgttg catagacacg aagaaggaag   1320
 tattctaatt aacaaggaca gaggactgac cggttccatt tttttttttt tccaaacaat   1380
 cactcagctg gaagggcggc tctctattgg ggccttgcat ttcaaaaacc ctgcagattt   1440
 tttttaaaag aaattttcat tttactaaac aaaatacttc ctatttgagc ccatgggggg   1500
 aaaatttaat attcttaatt taactgtaca tttctttatg gaaatggatt atctacactc   1560
 agtttcatta cagggaagga acccatgaaa acatcagtgt taagagcatg atgaaaggtg   1620
 tcaataaagc cgtaggatcg cgcaaccctt tgtgtgtgtg gctgctggta cgtgtgatct   1680
 ttgaaaacct tggctttagc cctctggaat cagagcttac ccaccatagt atattttgat   1740
 attaggtggt tctacacata gttggcaaaa tgacttggta aatttgtaat gctgaagtat   1800
 attagtataa gttaaatttg atgtgtcaac tttattttgt atttccttcc atttggaagg   1860
 tttgttagac cattaaggtt atattaaagt actcttgtgt gtgctaaaaa              1910



      <210> 1479
      <211> 1090
      <212> DNA
      <213> Homo sapiens


      <400> 1479
 atgagacaaa agagaaaaga agagaaagaa ctgtttcaca ataaagattg tgaaaagaag     60
 gaaaaaaatt cctgggaacg aatgagacat acaggaactg agaaaatggc atctgaaagt    120
 gaaacaccta ctggagctat ttcacagtat aaagaaagga tgccttctgt cactcatagt    180
 ccagaaataa tggatctgtc agaactacga ccattctcta aaccagaaat agcactgaca    240
 gaagccctga ggcttttggc tgatgaggat tggataagca actccatgca ctggaacagc    300
 tgctggcttc ctgctacagc gggaccagac ataccacaag cagcttccac tgtgggcacc    360
 agggaatgtg gtggcaccca gaagcttgga gatgccagca actgcagaac cccaaagaga    420
 gcctggaaaa agcaccataa gttctcactc cagtctgtgg aactagcagc ccactcccac    480
 aagcttcagt ctgtccctgg cttgaaggtg aaaaatttac gttctggagt ttctcgtgct    540
 gctgtggtct gtttaagtga tcttttcact tatttgaaaa agagcatgga tcaagagcta    600
 gataccacag taaaagtttt gttgcacaag gctggtgaat caaatacatt tataagagaa    660
 gatgttgaca aagcattgag agctatggtt aataatgtaa ctcctgcacg tgcagttgtt    720
 tctcttatca atggtggaca aagccattta cacattgctg taagaaggtg tacagcccag    780
 catttatcag atgtattgga atttatggaa ccagaacgta ttttatctgc agcaaaggat    840
 atggctgaac gcatattacc agctgctgct aagtttgctc aagacagttc acaagaaacc    900
 aggtattatg gtcgaaagat gctgttcttc atgatgtgtc atcctaactt tgaaaaaatg    960
 cttgaaaagt atgtcccatc taaagatttg ccatatatta aggactctgt tagaaactta   1020
 cagcaaaagg tatgtgggaa aagtttgttt tataaacagc tttataagca aagcttgttt   1080
 ttacatccag                                                          1090



      <210> 1480
      <211> 2580
      <212> DNA
      <213> Homo sapiens


      <400> 1480
 gcgcgccgag gatgcgggac tagccgggca ggctgctggc ggccgtcggg ccagcgaggc     60
 ctcgcagcgg gcgggccctg gcgagtagtg gccgggcgcc gccccctgcg ccctgaggcc    120
 cgggccccgc cgcttctgct ttcccgcttc tcgcggcagc ggcggccgag gaggcgcccg    180
 cgccggccgc ccccggggga agccgcgccg tctccgcctg cccggcgccc tgacggccgc    240
 tgttatgcgt attcccgtag acccaagcac cagccgccgc ttcacacctc cctccccggc    300
 cttcccctgc ggcggcggcg gcggtcaaga tgggcgagaa cagcggcgcg ctgagcgcgc    360
 aggcggccgt ggggcccgga gggcgcgccc ggcccgaggt gcgctcgatg gtggacgtgc    420
 tggcggacca cgcaggcgag ctcgtgcgca ccgacagccc caacttcctc tgctccgtgg    480
 tggccctcgg acttggggct gcaacaagac gctgcccgtc gccttcaagg tggtggcatt    540
 gggggacgtg ccggatggta cggtggtgac tgtgatggca ggcaatgacg agaacttact    600
 ccgttgagct gcgcattgcc tcggccgtca atgaagaacc aggtggccag gttcaacgac    660
 cttcgcttcg tgggccgcag tgggcgaggg aagagtttca ccctgaccat cactgtgttc    720
 accaacccca cccaagtggc gacctaccac cgagccatca aggtgaccgt ggacggaccc    780
 cgggagccca gacggcaccg gcagaagctg gaggaccaga ccaagccgtt ccctgaccgc    840
 tttggggacc tggaacggct gcgcatgcgg gtgacaccga gcacacccag cccccgaggc    900
 tcactcagca ccacaagcca cttcagcagc cagccccaga ccccaatcca aggcacctcg    960
 gaactgaacc cattctccga cccccgccag tttgaccgct ccttccccac gctgccaacc   1020
 ctcacggaga gccgcttccc agaccccagg atgcattatc ccggggccat gtcagctgcc   1080
 ttcccctaca gcgccacgcc ctcgggcacg agcatcagca gcctcagcgt ggcgggcatg   1140
 ccggccacca gccggcttcc accataccta cctcccgcca ccctacccgg gggccccgca   1200
 gaaccagagc gggcccttcc aggccaaccc gtccccctac cacctctact acgggacatc   1260
 ctctggctcc taccagttct ccatggtggc cggcagcagc agtgggggcg accgctcacc   1320
 tacccgcatg ctggcctctt gcaccagcag cgctgcctct gtcgccgccg gcaacctcat   1380
 gaaccccagc ctgggcggcc agagtgatgg cgtggaggcc gacggcagcc acagcaactc   1440
 acccacggcc ctgagcacgc caggccgcat ggatgaggcc gtgtggcggc cctactgacc   1500
 gccctggtgg actcctcccg ctggaggcgg ggaccctaac aaccttcaag accagtgatg   1560
 ggccggctcc gaggctccgg gcgggaatgg gacctgcgct ccagggtggt ctcggtccca   1620
 gggtggtccc agctggtggg agcctctggc tgcatctgtg cagccacatc cttgtacaga   1680
 ggcataggtt accaccccca ccccggcccg ggatactgcc cccggcccag atcctggccg   1740
 tctcatccca tacttctgtg gggaatcagc ctcctgccac ccccccggaa ggacctcact   1800
 gtctccagct atgcccagtg ctgcatggga cccatgtctc ctgggacaga ggccatctct   1860
 cttccagaga gaggcagcat tggcccacag gataagcctc aggccctggg aaacctcccg   1920
 acccctgcac cttcgttgga gcccctgcat cccctgggtc cagccccctc tgcatttaca   1980
 cagatttgag tcagaactgg aaagtgtccc ccacccccac caccctcgag cggggttccc   2040
 ctcattgtac agatggggca ggacccagca cgctgctggc agagatggtt tgaggaacac   2100
 atccaagcca gtccccccag gcccagcttc ccctccgttc ctaactgttg gttttccccc   2160
 agccgcacgg gtcccaggcc ccagagaaga tgagtctatg gcatcaggtt cttaaaccca   2220
 ggaaagcacc tacagaccgg ctcctccatg cactttacca gctcaacgca tccactctct   2280
 gttctcttgg cagggcgggg gaggggggat aggaggtccc ctttccccta ggtggtctca   2340
 taattccatt tgtggagaga acaggagggc cagatagata ggtcctagca gaaggcattg   2400
 aggtgaggga tcattttggg tcagacatca atgtccctgt acccccctgg gtccagccaa   2460
 gctgtgcccc atcccccaag cctcctggga ggatccagcc aaatcttgcg actcctggca   2520
 cacacctgtc tgtaacctgt tttgtgctct gaaagcaaat agtcctgagc aaaaaaaaaa   2580



      <210> 1481
      <211> 446
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(446)
      <223> n = a,t,c or g


      <400> 1481
 tttcgtcggc ggccacggaa gcggccaagg gggcggtggc gcaaagaggg gtgcggagcg     60
 ggcggaagag gcgtctgtgt cgcagcttgg tctcagagga gcatcgctgg gaacaacgac    120
 tatcgtctat tccacaagat gagtaacagc caccctcttc gcccctttac tgcagtgggg    180
 gaaattgatc atgtgcacat tttgtctgaa catatttgtg ccttgttgat tggggaagaa    240
 tatggcgacg tcacattcgt gggggaaaag aaacgttttc ctgcccacag ggtaatttta    300
 gcagccaggt gccaatattt tcgagcatta ttatatggtg gaatgcgaga gtctcagcct    360
 gaagcagaaa ttcctctcca agacaccact gcagaagcat tcacaatgct actcanatat    420
 atctacactg ggcgggcaac gctgac                                         446



      <210> 1482
      <211> 714
      <212> DNA
      <213> Homo sapiens


      <400> 1482
 ggggcgccaa agccggtcca acaccccttg cttccggtgc ccaccccaca ccccacggtg     60
 cacagcttca tctccaacca tggcatcttc tctctgctta gcagcagtgc tgccacagcc    120
 ctgctgatcc agcgcaccaa tgaggaggag aagtggctgg cgcggcagcg gcggctgcgg    180
 caggagaagg aggaccggca gtctcaggtg tccgagttcc ggcagcaggt gctggagcag    240
 cacctggata tgggccggcc cccggtgccg gcggaggcag agcacaggcc ggagagcacc    300
 accaggtgag tgagccccag gaaggaagga gggatgagcc ttcacgttcc gatttgttca    360
 gcgtgtattg agcacctcct gtttgcccga catcctgccc cagcgtttct gcctgcctct    420
 ttcatttctg ttctttcatc ttcacgttat aatgcctgtc ttgcctatgg ggaagctgag    480
 actgaggaag aaaatggatt gctcaaaggt atccccacca gtaagtaaag agaccaatca    540
 agtccatgtt gagagccagg gcactgcaca cgcagcctga cctagttccc aggaggccat    600
 tcacagcaga tgaagagtgc aaggtagaag ctttaattac taataatacc tgttctctcc    660
 atcttcctct gcttttgagc ctggacttct tttttaacaa gaaggggact cccg          714



      <210> 1483
      <211> 413
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(413)
      <223> n = a,t,c or g


      <400> 1483
 tcatcataaa atggaatcga atggaatcac catcaaatgg aatcaaatgg aatcattgaa     60
 aggaattgaa tggaatcttc atcgaatgaa ttgaatgcaa tcatcgaatg gtctcgaatg    120
 gaatcgtctt caaatggaat ggaatggaat catcgcatag aatcgaatgg aattatcatc    180
 gaatggtatc accatcaaac ggaaaaaaac ggaattatcg aatggaatcg aagagannnn    240
 nnnnnnnnnn nnnnnnnnnn ncatctnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    300
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nncatcgaat ggactcgaat gcaataatca    360
 ttgaacggaa tcgaatggaa tcatcatcgg atggaaacga atctcgtgcc gaa           413



      <210> 1484
      <211> 1371
      <212> DNA
      <213> Homo sapiens


      <400> 1484
 ctcggcttta ctgcagcctc cgcttcctgg gttcaagcga ttctcctgcc tcagcctccc     60
 gagtagctgg gactacaggc gcgtgtgcca cgccggctaa ttttttgtat ttttagtaga    120
 gatggggttt caccatgtta cccaggatgg tctcaatatc ctgagttcat gatccaccca    180
 ccttggcctc ccaaagtgct gggattacag gcgtgacgac cacacccagc cagttttcct    240
 attttctgaa ttcagaattg acttctctgg gaaaactgga gatgagaatc tgcccagtgc    300
 tctgctgtcc agtcaccgcc ttttgaattt tagttttggg caccagggag taccgttagc    360
 tttccccttc ttctggccca ctttgacttc accacgcaca ataggggtca acacctttaa    420
 ctttttaatt tctaatctgc tttactgtct ttaggggtgt gtatggaaat aaaacattga    480
 acagggtttc ttggaggccc tcaagggtgc ctactttgct gggttccctt ttccagcagc    540
 tcccccaccg tcccttagcc cccccgtcct cgtggcagcc tctcctgcct ctgctgagct    600
 cccctccacg tgttccaccc ccttaccctg ctgttgttta catccaacct gcctgagaat    660
 ttcctctggg gaggaatcta ttcctgtcat ggtctagtgc ctgggaggga gagaactttc    720
 tgggggtagg gtgccctcca tctgaaacag gccaggtgag catcatgcat aaggcctcca    780
 ttctgtccgc tcagattctg ggtggggcca caggcaaatc tcctgactta tggggagttg    840
 gcttgtggtt cctcccttgg atagcctcca tggaaccact ataggctttc cccaaaaagc    900
 tgccctctga aaatagctgc tgccttcgaa gatccctccc ctttttaaaa gcactttcct    960
 aaagcccctc agggatggcg ggagcaaaca gcactggtat attctaagga gtaaagtgca   1020
 ggaattcagc agtgagagca tgtctgggac ccacccggac tggcctccaa ttaactccca   1080
 aacctctttt ggggaaactc gccctccctg gggaaccaga gttctggctc taacattgga   1140
 ggcagctatg cacttagttc cagaggaagc cactaacagg cttgccatgt gttaggatgt   1200
 taggttctta aggagttcac agggcttggg ttcatctgat cactggatgg atagctcagc   1260
 ctgggggcat ttttagtgtt tttccctggt gataaatccc caaggcagct ggatttggag   1320
 ctggtggcaa gttgaaatta ttaaaaataa atttgtgtgg gactgtcaaa a            1371



      <210> 1485
      <211> 399
      <212> DNA
      <213> Homo sapiens


      <400> 1485
 ggcacgagcg ggctggtgga cttggtatta atcttacagc tgctgatacc tgcatcatct     60
 ttgattcaga ctggaatcca caaaatgacc tgcaggtaaa ggaattcatt gtcttaggga    120
 ctaactacct aacttgggag atttttcaac aagaatagga tcttttagaa agacctttca    180
 cagagtttgg aattgtttcc ttagttaagg gtggcagtta ggtcagggaa tcagcaaacg    240
 ttttctgtaa acgacaagac agtaaatgtt ttaggctttg tgagccatcg agtctttgtt    300
 gcaactgctt atctccaagt cctgtagcgc aaaaacagcc atagataata tgtaaatgag    360
 tgggtggtcc cacctgtgtc cccattgaac tttattttt                           399



      <210> 1486
      <211> 639
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(639)
      <223> n = a,t,c or g


      <400> 1486
 gaaaaagtag ctgttctctg taaagaaaac tatctacttc cagaagcaaa agaaattgta     60
 tgtaaagatg gacgatggca atcattacca cgctgtgttg agtctactgc atattgtggg    120
 ccccctccat ctattaacaa tggagatacc acctcattcc cattatcagt atatcctcca    180
 gggtcaacag tgacgtaccg ttgccagtcc ttctataaac tccagggctc tgtaactgta    240
 acatgcagaa ataaacagtg gtcagaacca ccaagatgcc tagatccatg tgtggtatct    300
 gaagaaaaca tgaacaaaaa taacatacag ttaaaatgga gaaacgatgg aaaactctat    360
 gcaaaaacag gggatgctgt tgaattccag tgtaaattcc cacataaagc gatgatatca    420
 tcaccaccat ttcgagcaat ctgtcaggaa gggaaatttg aatatcctat atgtgaatga    480
 agcaagcata attttcctga atatattctt caaacatcca tctatgctaa aagtagccat    540
 tatgtagcca attctgtagn tacttctttt attctttcag gcgttgttta actcagtttt    600
 atttagaact ctggattttt agagctttaa aaatttgta                           639



      <210> 1487
      <211> 236
      <212> DNA
      <213> Homo sapiens


      <400> 1487
 gatgaaatct cttgcagagc agatgcgtaa ccacgaccgc gagcagatga gccgcatggc     60
 ccataacctg ccagagcagt accaggagtg cgcgccggtc gagcaggtgg cgcaggtatt    120
 caacaagctg ttcaacgagc tgcgcgccgc gttcccggcc agcatggcga acttccgcac    180
 ccaggaagac ctgaacgaat tccaccgtca gtggctgctg gcgtttcagg agaacg        236



      <210> 1488
      <211> 1623
      <212> DNA
      <213> Homo sapiens


      <400> 1488
 aatacatgga ggcagggact ttgggtcaaa ttactggggg aaatggaaaa gttaatatgt     60
 atgtagtagg gaacaggggt tatactaggt taggcagaga agccttggag ttttctcaga    120
 atctgcactg agggttaagg gaggtatcta tgaaagggtg tgcaacttcc ccaaaccgca    180
 gcaactccag ccagtttccc ggtactgcct tgccctggtt ttgcaggtgt ggctggaccc    240
 agtttaaata tctggccaca agctcagcca gactctggtt ccctcggctg ttcactccca    300
 ctgggcttct ggtcccagcc ccatctcagt cactgtggtt ggtcagaaga cagtaaatcc    360
 caaacttgat tagttgcaaa gtccatctgg cttggttttc tgttgctgat agagagacca    420
 ggggagtttc tgtgtgagag aacgggggac tattctcact tcttccaccg cacaagctgc    480
 tcaaggtggg ctgcatggct ggtctggctg gaaatactga aacagctctc cttcacctac    540
 ccctagagta ggccggatgt gaccccagga atgagaatat accagggcag atacagacac    600
 agaaatgttt tgcctgatgg cattaggttt attttgtggg aaagcagaat tggggctctc    660
 tgaaaggcac ttgtgaggca tagaagtaaa ggttgccaca tggctaatgg tggacgtctt    720
 cctggcatcc ttgggggtag gggaaagaca gacagctccc agggccacag aaaatacctc    780
 tatcagatag agaaatccga gtcccagtgc cttatggtgg agccaagggt taagcagatg    840
 gcctgctttt tttatacgaa gagtttgctt cctccgggca atcttaaagt ctggcattca    900
 cggctggagg tatagggccc atccacttct ctcccagcag gtgcgccagc agctccatcc    960
 ggtcagagcc aaataacatg tgggtttggc catccacatg ggccacggtg atgggcagcc   1020
 caaaggctcc gtatctgcag gctgcctcag tggtctcctt gagctggttc ttcacctttg   1080
 gcgttgcgat cttttccaga agtccctggg cttgttctgc agacatacca gccttctctg   1140
 cagccgccag gatgctctgc ggctcggtga tgtcttcatt ccttgaccag acgcgcatcc   1200
 acagctcccg ggacgctttc tccagcatct ctggatgctc caagttcacg gcggtgagga   1260
 aacgcatggc agacaaactt cctttttcaa gcatcacaga caagaaatcc ttggggaagt   1320
 ggatgggaat ctggagatgg tgtctcagga gctttaagtc atttgccatg tatagtcctt   1380
 tgcggggaag cagacctgga ggcttgtttc cactgtcttt catgatccct gttatgaggc   1440
 tgggccgcaa ctgcaggttg atgttccaga tattctgata ccggcacagg atctcgaagc   1500
 ccagccagga gtagggggac agcacgtcat agaagagctc cacggtgcgc ggcaggggcc   1560
 ccatgctgca ggctccggaa gagcagtggc agcaggagct ccttttcccg gaacccggca   1620
 gag                                                                 1623



      <210> 1489
      <211> 1623
      <212> DNA
      <213> Homo sapiens


      <400> 1489
 aatacatgga ggcagggact ttgggtcaaa ttactggggg aaatggaaaa gttaatatgt     60
 atgtagtagg gaacaggggt tatactaggt taggcagaga agccttggag ttttctcaga    120
 atctgcactg agggttaagg gaggtatcta tgaaagggtg tgcaacttcc ccaaaccgca    180
 gcaactccag ccagtttccc ggtactgcct tgccctggtt ttgcaggtgt ggctggaccc    240
 agtttaaata tctggccaca agctcagcca gactctggtt ccctcggctg ttcactccca    300
 ctgggcttct ggtcccagcc ccatctcagt cactgtggtt ggtcagaaga cagtaaatcc    360
 caaacttgat tagttgcaaa gtccatctgg cttggttttc tgttgctgat agagagacca    420
 ggggagtttc tgtgtgagag aacgggggac tattctcact tcttccaccg cacaagctgc    480
 tcaaggtggg ctgcatggct ggtctggctg gaaatactga aacagctctc cttcacctac    540
 ccctagagta ggccggatgt gaccccagga atgagaatat accagggcag atacagacac    600
 agaaatgttt tgcctgatgg cattaggttt attttgtggg aaagcagaat tggggctctc    660
 tgaaaggcac ttgtgaggca tagaagtaaa ggttgccaca tggctaatgg tggacgtctt    720
 cctggcatcc ttgggggtag gggaaagaca gacagctccc agggccacag aaaatacctc    780
 tatcagatag agaaatccga gtcccagtgc cttatggtgg agccaagggt taagcagatg    840
 gcctgctttt tttatacgaa gagtttgctt cctccgggca atcttaaagt ctggcattca    900
 cggctggagg tatagggccc atccacttct ctcccagcag gtgcgccagc agctccatcc    960
 ggtcagagcc aaataacatg tgggtttggc catccacatg ggccacggtg atgggcagcc   1020
 caaaggctcc gtatctgcag gctgcctcag tggtctcctt gagctggttc ttcacctttg   1080
 gcgttgcgat cttttccaga agtccctggg cttgttctgc agacatacca gccttctctg   1140
 cagccgccag gatgctctgc ggctcggtga tgtcttcatt ccttgaccag acgcgcatcc   1200
 acagctcccg ggacgctttc tccagcatct ctggatgctc caagttcacg gcggtgagga   1260
 aacgcatggc agacaaactt cctttttcaa gcatcacaga caagaaatcc ttggggaagt   1320
 ggatgggaat ctggagatgg tgtctcagga gctttaagtc atttgccatg tatagtcctt   1380
 tgcggggaag cagacctgga ggcttgtttc cactgtcttt catgatccct gttatgaggc   1440
 tgggccgcaa ctgcaggttg atgttccaga tattctgata ccggcacagg atctcgaagc   1500
 ccagccagga gtagggggac agcacgtcat agaagagctc cacggtgcgc ggcaggggcc   1560
 ccatgctgca ggctccggaa gagcagtggc agcaggagct ccttttcccg gaacccggca   1620
 gag                                                                 1623



      <210> 1490
      <211> 1606
      <212> DNA
      <213> Homo sapiens


      <400> 1490
 ccagcacatg acgacttcta tctcgtagtg tgcagtgcct gtaaccaggt cgtcaagcca     60
 caggttttcc agtcgcactg cgagagaaga cacggttcaa tgtgtagacc ttctccctct    120
 ccagtgtctc cagcctccaa tcccaggaca tcactagtac aggtgaaaac aaaagcctgt    180
 ctcagcggcc atcactctgc cagcagcacc tcaaagccat tcaaaacgcc caaagacaat    240
 ctacttacct ccagcagcaa acagcacaca gtctttcctg cgaaaggatc aagggataaa    300
 ccatgtgttc cagttcctgt agtcagttta gagaaaattc ctaacctagt gaaggcagat    360
 ggtgccaatg tcaaaatgaa ctccacaacc actactgcag tttctgcctc ctccacctcg    420
 tcctctgccg tctccacccc tcctttaatt aagcctgtcc tgatgtccaa gtcagtgcca    480
 ccttcaccag agaagatctt aaatggcaaa ggaattctgc caaccaccat agacaagaga    540
 cgccaaaatg gcaccaacag cagcaacaag ccttacagga gactttcaga gagagaattt    600
 gacccaaata agcactgtgg agtattggat gccgagacaa agaaaccttg cacaagatcc    660
 ctcacctgca agacacattc gctaagccat cggagggcag tcccaggccg gaaaaagcaa    720
 tttgacctcc tcctggcaga acacaaagca aagtcccggg aaaaagaagt taaagataaa    780
 gagcatctcc tgacttccac gagggaaata cttccaagcc aatccgggcc ggcacaggat    840
 tctctgctag ggtcttcagg gagctctggg ccagaaccaa aagttgcatc ccctgcaaaa    900
 tccagaccac ccaactctgt acttcctaga ccatcatctg caaatagcat aagcagcagc    960
 acatcttcaa atcatagcgg ccacactcca gagcccccac tcccaccggt tggaggtgac   1020
 ctcgccagcc gactgtccag tgatgaaggg gagatggacg gagccgacga atccgagaag   1080
 ctagactgtc agttctccac gcaccacccc agacctatgg cgttttgctc atttgggagt   1140
 cgcctcatgg gacgagggta ctatgtgttt gatagaagat gggatcgttt tcgattcgca   1200
 ctaaactcca tggtagaaaa acacctgaat tcacagatgt ggaagaagat ccctcctgcg   1260
 acagatagcc ccctgccctc gccagcagcc cacatcacca cccccgttcc agcatccgtt   1320
 ttgcagcctt tcagcaaccc cagtgctgtg tatcttcctt cagctcccat cagctcgagg   1380
 ctcacctctt cttacataat gacatcagcc atgctctcaa acgcagcttt cgtgacatcg   1440
 ccggacccga gcgccctcat gtcccacacc acagctttcc ctcatgtggc cgcaaccctc   1500
 agcatcatgg actcaacctt caaggcccca tccgccgtgt ccccgatacc agccgtcatc   1560
 ccttccccat cccacaagcc atccaaaacc aaaaccagct acgaaa                  1606



      <210> 1491
      <211> 414
      <212> DNA
      <213> Homo sapiens


      <400> 1491
 ggtggcacga ggacctcgtc tacgtggagg ccttctccca gcatgccatc accggccggg     60
 cactgctgcg gctgaatgcg gagaagctgc agcggatggg gctggcccag gaggcccaga    120
 ggcaggaggt gctgcagcag gtgctccgcc tgcaggtgcg tgaggagggg cggagcctgc    180
 agctgctcag ccaagcttcc ttcgggaaaa tgtcctaact gctgctgagg cttgaaccca    240
 gaccccagca ctgtgatggg agtccacggc tagggaggag gccaagctgg ccccgcagcg    300
 cctcttggac cctgcgggat gccggggcgg ccaggctggc ccaacggaca gacaggacca    360
 ggatcacacc tccaggcgcc tctggttgga cattccaggt cgtgccctgg ggct          414



      <210> 1492
      <211> 415
      <212> DNA
      <213> Homo sapiens


      <400> 1492
 gctgagcttt tgctcgccgt ccaccactgc tgtttgtcgc tgtcgcagac ccgctgctga     60
 ctgccatccg tctggatccg gcagggtgtc cactgtgctc ctgatccaat gaggcaccca    120
 ttgccgctcc cgatccggct aaaggcttgc cattgttcct gcacagctag gtgcccgggt    180
 ttgtcctaat ccagctgaac gctagtcact gggttccacg gttctcttcc gtgatccacg    240
 gcttctaata gagcgataac actcaccaca tggcccaaga ttccattcct tggaatccat    300
 gaggccaaga accccaggtc agagaacaca aggcttgcca ccatcttgga agcggcccgc    360
 caccatcttg ggagctctgg gagcaaggac cccccgaccc aataagagtt tcgca         415



      <210> 1493
      <211> 397
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(397)
      <223> n = a,t,c or g


      <400> 1493
 cgccgcagat gcttaccccg caacagatgc agcttatcct gtcgcccccg cagctgcagg     60
 ccttgctcca gcagcagcaa gccctcatgc tccagcagct acaggagtac tacaagaagc    120
 agcaggagca gctccacctg cagctcctca cccagcagca ggctgggaaa ccgcagccca    180
 aagaggcact ggggaacaag cagctggcct tccagcagca gctcctgcaa atgcaacagt    240
 tgcagcagca gcacctgctc aacctgcaga ggcaggggct ggtcagcctg cagcccaacc    300
 aagcctcggg gcccctccag acccttccgc aagcagctgt ttgcccaaca gacctgcccc    360
 agctggggaa gggcgagggt gcccccgggc agcctgn                             397



      <210> 1494
      <211> 410
      <212> DNA
      <213> Homo sapiens


      <400> 1494
 atcgacctaa tggctgatga aatcgggctg tgggctgtgt atgcaactaa ccagaatgca     60
 ggcaatattg tcatcagcca acttaaccaa gataccttgg aggtgatgaa gagctggagc    120
 actggctacc ccaagagaag tgcaggggaa tctttcatga tctgtgggac actgtatgtc    180
 accaactccc acttaactgg agccaaggtg tattattcct attccaccaa accctccaca    240
 tatgagtaca cagacattcc cttccataac caatactttc acatatccat gcttgactac    300
 aatgcaagag atcgagctct ctatgcctgg aacaatggcc accaggtgct gttcaatgtc    360
 acccttttcc atatcatcaa gacagaggat gacacatagg caaatgtatt               410



      <210> 1495
      <211> 3289
      <212> DNA
      <213> Homo sapiens


      <400> 1495
 gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta     60
 ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt    120
 cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc    180
 cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca    240
 acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc    300
 cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg    360
 acatgattac gaatttaata cgactcacta tagggaattt ggccctcgag gccaagaatt    420
 cggcacgagg tttttttttt tttaagtggg acaattaaaa atttaaaaaa taattttaaa    480
 atagaacagc ttagagatag gaaacctaaa tttatttccc aattccttac tgtgccccca    540
 aaaccagggt tcaccaaaag ggctgtcctc ccaacaattt tctgaattct atatattcag    600
 cattaaattc catgataaag ttggaaatcc attcaccatt tgtaatacat attgatgcat    660
 ttaataaaat tgcatgggcc gtatcttttg catttctgta tcctagtatt aagtacagtg    720
 cctaccacag gccaggttct caatacttga ataaatgaca caaaaatagc caggaccagc    780
 aagttttttc tgggtgggct tcatagaatc tctgtacttg ctggaatcac catgaaatcc    840
 atggtcttca gctttgcatt ttcagcaaca tagttatatt gagttatcct caggtgagca    900
 gtgagaccct tgggagcgga ttcatggtag ggtggctttg taatgtgtca ccttggtgag    960
 gctatgtttc ccggaactct cttccagtaa gatgggccac aagagacatt ttgcttgata   1020
 accggagggc ggaagtgaag cagcagcaca ttgtttttac acttggaagg ttggtgctgg   1080
 ggcaccaggc gttgttgcag ttcacacgtt gccatgtatc tgctagatca cctcgttggt   1140
 gtgggcagta gtcaggcctg cagccaggcc tgcagctgct ccaccttccc caggatcatc   1200
 ctttcagctt ctctaattcc tgggccagat gcatatttaa ctctgtgagg aagggcacca   1260
 gcttcttctg caggacaccc acatcatcga agctggaggt ggtgagagac tgacatgggt   1320
 tccaggccat cctcgtgggt tccagctcgt gctcgtgggc tccactgtgt cctcggtctc   1380
 ccacacttta catccatctt cccttcccga gtgcctgccc tgcagacttg aatcctacag   1440
 tctgtagaag cctccagtca actgctttct agctccaggt tttttaaggt ctttggacct   1500
 tggcaaccag actgctgtat ctcggaagcg ggttccaccc aggctgaaaa tctccgtgat   1560
 cacgggtgtg ccagcccctc ctgcctcttc ctctggggcc aatttggagg cagaatcatc   1620
 cttgttctcc tccttgtcct cctctgggtc aggtggctct tgcttcacag aaggcaggcc   1680
 tgggtctact gccttgctag ggcagccagg caccaatacg ggagaagtca ggacagctgt   1740
 gcctggtgtc cactcgtcct gggtatccgc cttctcttgc ttcacctggg gtaaggccac   1800
 aacccaactc atgccagaac actgggcytc ctgcaacagg gcttctgtgg aagctgcaac   1860
 agggcccggc acctgcacag gamtgcttgc gcccttcccg taaaaaacac aaggttcagt   1920
 gcccaggcgg gggcagcaca aagccaccac ctgcttcctg cttcgttgga gcctgggtat   1980
 ggtctggttg ggctgtgcgt gtagccaagg tgggcttcaa ggtagggcca agatggtgcc   2040
 gtcgggcaga gctgggcctc tttcgacgac ggtaaggtgg gggcgatcct gccccatcct   2100
 cagactctga ccagacactg ggcagcagcc gcttcatggc aaactgcagg cattggcgcc   2160
 aacgacactt ctggcgcttc tggttgctgc ccccgaattt gggcttgtcg cagcagaagt   2220
 cgcagcggcc acatccattc cgccgtaggc aggctgcaca ggccccgcac ttgcggttct   2280
 gccggcggtt cgtgtagggc tgtagctcgt cctcgtctac acagtaatag atgaactcgg   2340
 caggtggcga gggggccagg gctctggggt gcggctctgt gggctctggg gactgtgatg   2400
 ggggtggtgg aggcagtggc tgggctccgg ggcgccgcct ggcagccatc ttggagtcac   2460
 agcctccctt gcggcgggca tgtttacccc gtaggcaacg tcgctggaca catttccact   2520
 ggcgcctgag accagggcgg ggagggcgaa ggcagatggg gcaatggcca caatcytctt   2580
 gggtctgaca gccccggcat actccacacc ctcggctctt aaacattctc tgttcccggt   2640
 tgaaggcaat tctctgtgct cgacagtctt tgcacaacgt tttgagccgc tgcctttggg   2700
 tgccatcccc tgagaagctg attccacagt tctcacagca cccaggagca gggaatgaag   2760
 ctggggctgt gtcagtgtca gccttggtct catccctcgg ggcctccttc ctgacctcac   2820
 cactctgggg tccaacctga cgtttccgag tcttggctgg ccttgaaggc ttctttcgct   2880
 tcttgctggc aaccgccacg ggatgggcct tgggggctgg atagcacaag atgccttgtt   2940
 tgaagtcgaa gagggtgaga tcacacgcag ggcccaggta tcgagtcagc tcaactttgc   3000
 ttcggatcct gtctcctgtg gggctctggt aataggtgtc tgagcgtcca caggtggccc   3060
 ctgacttgcg aaagacttcg cggcgcttcc agccagggcc cagggccggg cagtccagcc   3120
 agtcctcagc catggaggcc acaggaagca gcagtagcca gtttggcacc aggccggtat   3180
 cttccgccac tctaggcccg tggacccatg gcgagggtcc ctcctgcacc tcccgcctcg   3240
 ccctcctccc cttcctcctc ctccgcggcc ggggggagta tcacacaaa               3289



      <210> 1496
      <211> 504
      <212> DNA
      <213> Homo sapiens


      <400> 1496
 tcatgcagcc gtacgtaatc ttggatactc tacagcggac gcaatacagt gggtgtgtga     60
 gagtgtgtat gtctgtatat atacctacat gtatcagtag gtttatgaat gtgtatatga    120
 acatacaggt gtgtgtatgt gcaagtttgt gtgaaggtgt gtgcatgtgt ttctacaagt    180
 atgtgtatgt gcttgttaag tgcatatgta tgtgtacatg tgagggtatg tgcatgtgta    240
 tatgtgtgtg catcagtgaa tgtgtataca ggtgcatgca catgtgtatc attttttagg    300
 tgtcctgcct tttgccccct catacatgtg ctttgccccc tgctggtata ctccttcaga    360
 agctctctct tcatattatt tcctttgcac aaagtaaccc caagccgtag tttaataacg    420
 cacgctgaga gtgtatgtag atcaatttgt accagcctta aaagcaattt gtttaagcat    480
 aagaattctc gctttttaag tctg                                           504



      <210> 1497
      <211> 2363
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2363)
      <223> n = a,t,c or g


      <400> 1497
 actataccga gagactgaag aagtggaaat atatgtggaa cagagccttc ctccatggta     60
 tgaaatagat ttcctttaaa aaataaaaaa aaaagaagtg aacaatataa gcatattact    120
 tagaaacatg gaggtatata cctgaaaaac tcaagagttg aaagtggtca cctctgggga    180
 gtgggaatct tgaatgggag gaatgggctg gggctttttt gttataagcc ttgacttttt    240
 aaattatgat catgtgtaac tgataaaaat aaaagttaga ataaaagccc tagcacaatg    300
 tctgccataa agtaggccct tgataaagaa tggacattta tctaattgtc ccatctctcc    360
 acggctgctg ccccactttt tgcattcagc aatatagaca tttgatccgt tcctcaagat    420
 tctattctcc cccttcctaa caaagtatgg caggaaaaaa aaaaaatcac ggtttcaatg    480
 gacactttta ttgtttactt aatggatcat caattttgtc tcactaccta caaatggaat    540
 ttcatcttgt ttccatgctg agtagtgaaa cagtgacaaa gctaatcata ataacctaca    600
 tcaaaagaga actaagctaa cactgctcac tttcttttta acaggcaaaa tataaatata    660
 tgcactctag aatgcacaat ggtttagtca ctaaaaaatt caaatgggat cttgaagaat    720
 gtatgcaaat ccagggtgca gtgaagatga gctgagatgc tgtgcaactg tttaagggtt    780
 cctggcactg catctcttgg ccactagctg aatcttgaca tggaaggttt tagctaatgc    840
 caagtggaga tgcagaaaat gctaagttga cttaggggct gtgcacagga actaaaaggc    900
 aggaaagtac taaatattgc tgagagcatc caccccagtg aaggacgttt acacttcaag    960
 gagctccaaa actgggcacc acccccccag tgactcaaca tggctggact tttatcctcc   1020
 ggtgttccca tttgggcaac agccaagtgg gcaggtgtct ccaaccaacc tatgatggtg   1080
 atggcaagcc ccctagaagt ggatntgctt tcacccacct catccatgag agctttggtt   1140
 ccccggggca aaagcttccc attcaaatac ccccacagga ccattccaca caatctgctt   1200
 agcccgagtg acagcctcag catacttctt gctgctttca ggaccacagt ccaagcccat   1260
 ccagccagca ggtatgccag aagccacagt ggcttggcca gtcttggcat tctcatcaaa   1320
 cttgtcagca gtgacaaagt caacaggcaa ggtaatcttc acaccattct tctcagcttt   1380
 ggacattagg tctttgacaa tcttggctcc ctcttcatca aacagagaag tgccaatctc   1440
 catgttgttg agcaccttaa ggaaggtaaa agccattcca ccaccaataa tcatctcatt   1500
 gactttgtcc agcatattat tgatgagctg gatcttgtct gcaactttag ctccgcccag   1560
 gatggccagg aagggtcgct ctgggctctc caaggccttt gcaaagtagt tcagctcctt   1620
 cttcatcaaa aacccaccag ccttctgtgg cagattgact cctaccatgg agctgtgggc   1680
 tctgtgagca gtgccaaaag catcattgac atagacatcc cctagcttgg aaagtgaagc   1740
 tcggaaagct tctattttgg ctggctcggc tttaaccttg ttcccagaag catcttttcc   1800
 cttcccttct tcctccacat gaaagcggag gttctccagc aggatgacag acccagcagc   1860
 tgggttggca caggctttct ccacttctgg gcctacacag tccttcaaga acagaacatc   1920
 cttgcccagc agagatttga gttctacagc aactggctct aaggagtact tgtcaggcat   1980
 gggcacacca tcaggccggc ctaggtggct cataaggact accgacttgg ctccattgtc   2040
 caagcagaat ttgatgcttg ggacagcagc cttaatcctc tggttgtttg ttatctggtt   2100
 gttcttcata ggaacattga agtcgactct cataacgacc cgcttccctt taacgtccag   2160
 cttgtccagc gtcagcttgt tagaaagcga cattttggaa atacagctgg ggagagaggt   2220
 cggtgattcg gtcaacgagg gagccgactg ccgacgtgcg ctccggaggc ttgcagaatg   2280
 cggaacaccg cgcgggccct cgtgccaagc ttggcgtgtc natgtcagan ggctatcaat   2340
 nagggtttca attggggacg tcc                                           2363



      <210> 1498
      <211> 1148
      <212> DNA
      <213> Homo sapiens


      <400> 1498
 ggcacgagaa cgccggggcc agagtcttaa aaccgagggc ccgcaggggt ccccgcggcc     60
 gccgcgatgc agaaatacga gaaactggaa aagattgggg aaggcaccta cggaactgtg    120
 ttcaaggcca aaaaccggga gactcatgag atcgtggctc tgaaacgggt gaggctggat    180
 gacgatgatg agggtgtgcc gagttccgcc ctccgggaga tctgcctact caaggagctg    240
 aagcacaaga acatcgtcag gcttcatgac gtcctgcaca gcgacaagaa gctgactttg    300
 gtttttgaat tctgtgacca ggacctgaag aagtattttg acagttgcaa tggtgacctc    360
 gatcctgaga ttgtaaagtc attcctcttc cagctactaa aagggctggg attctgtcat    420
 agccgcaatg tgctacacag ggacctgaag ccccagaacc tgctaataaa caggaatggg    480
 gagctgaaat tggctgattt tggcctggct cgagcctttg ggattcccgt ccgctgttac    540
 tcagctgagg tggtcacact gtggtaccgc ccaccggatg tcctctttgg ggccaagctg    600
 tactccacgt ccatcgacat gtggtcagcc ggctgcatct ttgcagagct ggccaatgct    660
 gggcggcctc tttttcccgg caatgatgtc gatgaccagt tgaagaggat cttccgactg    720
 ctggggacgc ccaccgagga gcagtggccc tctatgacca agctgccaga ctataagccc    780
 tatccgatgt acccggccac aacatccctg gtgaacgtcg tgcccaaact caatgccaca    840
 gggagggatc tgctgcagaa ccttctgaag tgtaaccctg tccagcgtat ctcagcagaa    900
 gaggccctgc agcaccccta cttctccgac ttctgtccgc cctaggcccc gggacccccg    960
 gcctccaggc tggggcctgg cctatttaag ccccctcttg agaggggtga gacagtgggg   1020
 gtgcctggtg cgctgtgctc cagcagtgct gggcccagcc agggtggggt gcctgagccc   1080
 gaatttctca ctccctttgt ggactttatt taatttcata aattggctcc tttcccacaa   1140
 aaaaaaaa                                                            1148



      <210> 1499
      <211> 5654
      <212> DNA
      <213> Homo sapiens


      <400> 1499
 ggagcgacgc cgctcgggtc agtcggcggc cggactggga agatggacgc agctactctg     60
 acctacgaca ctctccggtt tgctgagttt gaagattttc ctgagacctc agagcccgtt    120
 tggatactgg gtagaaaata cagcattttc acagaaaagg acgagatctt gtctgatgtg    180
 gcatctagac tttggtttac atacaggaaa aactttccag ccattggggg gacaggcccc    240
 acctcggaca caggctgggg ctgcatgctg cggtgtggac agatgatctt tgcccaagcc    300
 ctggtgtgcc ggcacctagg ccgagattgg aggtggacac aaaggaagag gcagccagac    360
 agctacttca gcgtcctcaa cgcattcatc gacaggaagg acagttacta ctccattcac    420
 cagatagcgc aaatgggagt tggcgaaggc aagtccatag gccagtggta cgggcccaac    480
 actgtcgccc aggtcctgaa gaagcttgct gtcttcgata cgtggagctc cttggcggtc    540
 cacattgcaa tggacaacac tgttgtgatg gaggaaatca gaaggttgtg caggaccagc    600
 gttccctgtg caggcgccac tgcgtttcct gcagattccg accggcactg caacggattc    660
 cctgccggag ctgaggtcac caacaggccg tcgccatgga gacccctggt acttctcatt    720
 cccctgcgcc tggggctcac ggacatcaac gaggcctacg tggagacgct gaagcactgc    780
 ttcatggatg ccccagtccc tgggcgtcat cggagggaag cccaacagcg cccacttatt    840
 tcatcggcta agttgggtga ggagctcatc tacctggacc cccacaccac gcagccagcc    900
 gtggagccca ctgatggctg cttcatcccg gacgagagct tccactgcca gcacccgccg    960
 tgccgcatga gcatcgcgga gcttgacccg tccatcgctg tggtacgtgg cggccacctg   1020
 agcacacagg catttggtgc tgaatgctgt ttgggaatga cgaggaaaac tttcggattt   1080
 ttgcgttttt ttttcagcat gttgggataa gtactgtgtt cacgtggttg ggaatctgaa   1140
 gggtataaga gccggaactg tgtccttgca ccctcacgtc cctcccccag gcaccacctc   1200
 ctgtgcagcc ttcatggcct tcgagtggcc cagagagcgt gtgtctggat gtgagcgtgt   1260
 gtgggcgcgt gctgagtgtg catggatgag tgtgagccat ggtgagtgtg tccccctcac   1320
 acctacattt aaacacacgg gcggcccctc cacccacccc tgcaccacct tcgtcacacc   1380
 cacatttaaa cacgggcggc ccctccaccc acccactcct gcaccacctt ttgttttccg   1440
 gaggctctga cttgacctct ctgggggatt tcctaagaag gagcttccct gtttttccat   1500
 tttgattacc tagttgtgat ttttggtgtg tgatttatgc agacctgcct gccctcaaat   1560
 atatttgatg gggaaagagg ccaaaaaacc cccctagaaa tcatgaatga cggtgacatg   1620
 ctcagggaag cagttaaccg aatcgggggc tctgttgtgg atgctccgcc ccatttagga   1680
 ggaagaaggc agatctgggc ctgaaatggg acggtctctg agctgtggcg cagccccaga   1740
 gtgcacacca cgctccatgc acctcctggg cagggtggca gtagtgggga acatgggctg   1800
 gagctctgtg gctcacactt tttgtttgtt tgtttgtttt tgagacggag tctcactctg   1860
 tcgcccaggc tggagtgcag tggcgcgatc tcggctcact gcaagctccg cctcccaggt   1920
 tcacgccatt ctcctgcctc agcctctgga ttagctggga ctacaggcac ccgccaccac   1980
 gcctggctaa ttttctgtat ttttaataga gacgggtttt cactgtgtta gccaggatgg   2040
 tcttgatctc ctgacctcat gatccaccca cctcggcctc ccaaagtgct gggattacag   2100
 gcgtgagcca ctgcgcgcag cctggcgcac acttcttacc agaacctagt cacgaattcc   2160
 tcgtcgaact agaattaggt atgtttgtta ctgtaaacgc agcttggtgg cttacagtga   2220
 ttggcactct aacagtcagg tcaggctaga gagccagcca ccgcagacag aggagtggac   2280
 gcgtgaacgt tgagttgaga ccaaaggggc cacctggtgg gataactgtc ctcacccgtg   2340
 aggaggagga atgtcccctg tccccggggg agagtgctcc tacaccagcg ccgaggcggc   2400
 agaatggtgt cttcagggga agagagtgcc cagtttgagc ttctcccccc atttcgtttc   2460
 tttttgtgtt aacatctgcg catctggcag cgttgagaat tcctagtgac tgtcattaca   2520
 ggcggcagct ttaaggatgt gattgccggt gacccttggc cggtcccctg tctcctggct   2580
 cctcagcagg aggctccctg tgtcacggtg tccttgggca gttctcggtg gcctttgccg   2640
 ccaagcttcc agggagctgc tgggcgaagg ctgagaccca gcggccctgt ctcacagtca   2700
 cagagagaag agctccccac ttggccctaa ctcataacct gccccaatcc cggaacactc   2760
 ggtgaggttt gagagatgca caccacgtaa catctcgtgg gcgaatcaag gcacagcaac   2820
 gcagtggagc ctgaggggag ccgggcactg gtgcagggga ccatgcacag ggcaccctcg   2880
 gagctccatt cccggccaca ggagccaagg caggctggaa tgtccagcac ctgcatgctg   2940
 ggggcctctg ctgcgccact ggcagtggga atggaagccc ccacctctta tccgactgca   3000
 gatgggggtg tcgtgttctg ctcatcgtca tttcgtttta ggggtttttc tgtaagactg   3060
 aagatgactt cagtgattgg tgccagcaag tcaaaaagct gtctctgctt ggaggtgccc   3120
 tgcccatgtt tgagctggtg gagcagcagc cttcacatct ggcctgcccc gacgtcctga   3180
 acctgtccct aggtgagagc tgccaagtcc aggtggggtc cctcggaggt acgatctgtg   3240
 cccttgcttc cccagtcctg gcccccttgg ttttgaccat taaggtgtgt gtgagcctga   3300
 gccgtgagca cttggcagtg gttcgcctgt gagaccaggt atggagtgga gcgtcccctc   3360
 ctccaagctt gcgcccagca gcccaggacc cacctcgtct tccccaccag cgctgcctgc   3420
 cggggcgctg tggagctggg cgtgctacca tggagtcctc aggggtctgg agcagacaga   3480
 acatgcaggc tctgtggtga cgcagtcctg ggtgggggac tggttcactt gggcaccact   3540
 ggccatgggt ggcgtagacc cctcggacca tggccagcgt gccgcaggag ccggcctggg   3600
 ctcgtgcagt gaagtgagtg gccgtgagcg cgtcctcctc atctctgtct ccctgtggga   3660
 aactctacaa acaaggcaat ggcaatggaa ccactcctga tgaccacgag ggtcagacgc   3720
 gggacagagg cccctcaggc ctgagattgt gccggccgcc ccctgccctc ctcaccctgc   3780
 cctgctcctc ttctctgctc cctcccccca tattcgcagg tctgcacaac ccccggacct   3840
 gttcacaccc gcatggggac agctgtctgt gggctgcaga gcaggcactg ctcagtctgc   3900
 cccacgccaa gggcccttga ctcacaccca ggtggcccac ccaagatgcc tgatgcgcta   3960
 tgtcctgttc cttctagatt cttctgatgt agagcgactg gaaagattct tcgactcaga   4020
 agatgaagac tttgaaatcc tgtccctttg aaaatcctgg ggtcgggggt ggcacctgtg   4080
 agagcctggg gctcctggtg ccgctgcgtt tcatccatcc cgcccgctcg cctgccgagg   4140
 gctgcgcccc gtgctgcctc cccccagagg gccacccgct gtgctcgtgg actgaggctg   4200
 cgctgcccgg gaggccttac tgcttggtgt cagactgccc agctcagagt gcccgtcagg   4260
 gcctgtgcat ccgcacgcgg agccgtctgt taggagcttc cagagcgttc tctcgacact   4320
 gccagccccg tgttagcacc tgggcctcag tcccacttgc tcccaggcgc cggttctgtg   4380
 gttggtttgg aattaaagtc ctgtttgaag ttgtcagaca cagacatgaa tttctggggc   4440
 gctccctgag tcagtctcag aagacctgtg caggctggcg tgagaggagc ggcagccaca   4500
 ctgcggcccc acgcccaagg actgggctgc tctcgagggg ggcgcgccca ccgctgtgtc   4560
 ctctctgccc agcctggctt accaagggct acctcagtgg gagatgaggt tggaggaacg   4620
 aaggcgaggt tcctccttgc tttggggaga aaagtattca ggaagtgggt gtgtgggaaa   4680
 cctgaagatg gcgtgcacag gacacagcgt ggtcggcctg ggcagaaggg cggctggctg   4740
 tcctggagct gctgctggag cctgccctca gagtgtccct ttccagtgct gtggcattct   4800
 gtggcagctt ccccaggtgt ggtgacgggg ggggggcggg gcctccacct gtgacagcca   4860
 ggcttgaggg tggacggcgt gcctctccca ggagccttcc ccatgtcctt gccttgctga   4920
 gaattgccct cccatgccgc tgaggtgtta ggtggtttag ggccaaaagg ggaaaaccac   4980
 ttgagtcttg tggtgtgtgg tgggcagaca ccacagggtg gcatcacctg gtggcatttc   5040
 cagaacctca gccccgattc cagcacccac caccgcctga ccctgtgtaa cctgctgtcc   5100
 cgggtcccag agtgcactct gccccactgc tctgctgcct gtcctgggaa agtagctttg   5160
 ccccactagg aaatgtaaac aggagggctt ggggagcgtg ggcacttttc tcatgagcag   5220
 ctactgcggc gttggcagga ctcgctgctg ctgctgctgc tgcttgtgta ggtcggggag   5280
 ccggagatcc ccgaggacgc gcgccggaca gtcggcactg accggcccac ctggtagcag   5340
 aggacacccc cagcccccca agcattgaag acatagtgta tttcctcgta tcctttctcc   5400
 cttgggtgta gttggggtgg ggaagcaggg aaggctggtg cgatctccat tccttgggct   5460
 ccgcgtccga gttcatggtg cgccgctgtg ctgggagctg cagtgggaat gtgtgggaca   5520
 ccttgaccaa aggggagctt tgtctcgtgt gttttgaaaa aggcttaatg aagagaatgt   5580
 tgttcattct tagtagtata gtttgcaatt cttaatggca aataataagt ttcagtagaa   5640
 acccaaaaaa aaaa                                                     5654



      <210> 1500
      <211> 2445
      <212> DNA
      <213> Homo sapiens


      <400> 1500
 atgatctgta caattcattt ttccgcagaa tctaaacaaa atcttaatgt tgacaaagat     60
 actaccttgc ctgcttcagc tagaaaagtt aagtcttcgg aatcaaagga acgtggtgcc    120
 caggacaggc ggatccagga tctggaaact gagttggaaa agatggaagc aaggctaaat    180
 gctgcactaa gggaaaaaac atctctctct gcaaataatg ctacactgga aaaacaactt    240
 attgaattga ccaggactaa tgaactacta aaatctaagg gtatgatggc taagcaagaa    300
 ggcatggaga tgaagctgca ggtcacccaa aggagtctcg aagagtctca agggaaaata    360
 gcccaactgg agggaaaact tgtttcaata gagaaagaaa agattgatga aaaatctgaa    420
 acagaaaaac tcttggaata catcgaagaa attagttgtg cttcagatca agtggaaaaa    480
 tacaagctag atattgccca gttagaagaa aatttgaaag agaagaatga tgaaatttta    540
 agccttaagc agtctcttga ggagaatatt gttatattat ctaaacaagt agaagatcta    600
 aatgtgaaat gtcagctgct tgaaaaagaa aaagaagacc atgtcaacag gaatagagaa    660
 cacaacgaaa atctaaatgc agagatgcaa aacttaaaac agaagtttat tcttgaacaa    720
 caggaacgtg aaaagcttca acaaaaagaa ttacaaattg attcacttct gcaacaagag    780
 aaagaattat cttcgagtct tcatcagaag ctctgttctt ttcaagagga aatggctaaa    840
 gagaagaatc tgtttgagga agaattaaag caaacactgg atgagcttga taaattacag    900
 caaaaggagg aacaagctga aaggctggtc aagcaattgg aagaggaagc aaaatctaga    960
 gctgaagaat taaaactcct agaagaaaag ctgaaaggga aggaggctga actggagaaa   1020
 agtagtgctg ctcataccca ggccaccctg cttttgcagg aaaagtatga cagtatggtg   1080
 caaagccttg aagatgttac tgctcaattt gaaagctata aagcgttaac agccagtgag   1140
 atagaagatc ttaagctgga gaactcatca ttacaggaaa aagtggccaa ggctgggaaa   1200
 aatgcagagg atgttcagca tcagattttg gcaactgaga gctcaaatca agaatatgta   1260
 aggatgcttc tagatctgca gaccaagtca gcactaaagg aaacagaaat taaagaaatc   1320
 acagtttctt ttcttcaaaa aataactgat ttgcagaacc aactcaagca acaggaggaa   1380
 gactttagaa aacagctgga agatgaagaa ggaagaaaag ctgaaaaaga aaatacaaca   1440
 gcagaattaa ctgaagaaat taacaagtgg cgtctcctct atgaagaact atataataaa   1500
 acaaaacctt ttcaggaagt atcaaaactc cgctgtcagc ttgctaaaaa aaaacaaagt   1560
 gagacaaaac ttcaagagga attgaataaa gttctaggta tcaaacactt tgatccttca   1620
 aaggcttttc atcatgaaag taaagaaaat tttgccctga agaccccatt aaaagaagag   1680
 ttttgttctg tggcattgcc ttggatgata gaggtactga caacaactga ctctcagaaa   1740
 ctgctacacc agctgaatgc cctgttggaa caggagtcta gatgtcagcc aaaggtctgt   1800
 ggtttgagac taattgagtc tgcacacgat aatggcctca gaatgactgc aagactaagg   1860
 gactttgaag taaaagatct tcttagtcta actcagttct ttggctttga cacagagaca   1920
 ttttctctag ctgtgaattt actggacaga ttcctgtcta aaatgaaggt acagcccaag   1980
 caccttgggt gtgttggact gagctgcttt tatttggctg taaaatcaat agaagaggaa   2040
 aggaatgtcc cattggcaac tgacttgatc cgaataagtc aatataggtt tacggtttca   2100
 gacttgatga gaatggaaaa gattgtattg gagaagcctt ctgtgttggc attttctatc   2160
 attgcattag agatccaagc acagaagtgt gtagagttaa cagaaggaat agaatgtctt   2220
 cagaaacatt ccaagactac tacggggaat cagctaccag cttactgcca tgtggagaac   2280
 tgcacgagat tccgggattg gaatcaaaat gctaatttaa aaggtcaagt gaagctgctc   2340
 ctcacgtttt ggcgtgcctg cgctctctgc aggcagaagc gaacaaagac ccagcaagag   2400
 aaggcagagg ctaagaccca tcccgtatct gctctcctga aataa                   2445



      <210> 1501
      <211> 348
      <212> DNA
      <213> Homo sapiens


      <400> 1501
 ggcacgagga tacacgcacg cacttaaaag agagcatgtg gcatgttcat tgtggaacac     60
 aatatgaata cagggcatgc attttgcagc agggagactg tccacaaaaa ccttttgtac    120
 cggtcacggg agccctgtgg acatctgcac agccaagccg cgggacattc ccatgaatcc    180
 catgggcatt taccgctccc cggagaagaa ggcgactgag gatgagggct cagaacagaa    240
 gatcccggag gccaccaacc ggcgtgacgt ggaaccgacc aaggccaatt cccgctttgc    300
 taccactttc tatcagcacc tggcagattc caagaatgac aatgataa                 348



      <210> 1502
      <211> 3428
      <212> DNA
      <213> Homo sapiens


      <400> 1502
 ggagaaacgg agcccttgga agttgtaccc ttaggttccc ctgcggttct gggcccaggt     60
 ctgcagcctc cactctgggc ttgccggctg tgaggtgcgc tggttatagg actgtgtggg    120
 ggctgcatat caggtgatct cagctatcac cttctcccag cacctggctt ccagctcatg    180
 gggtgggact atcccactca cccctctgct ataggcactg cccatcttat gctgctggcc    240
 ctggcctcac ctggtcactt ccaccaacag gagctcccag ataacagtgg gttgctggac    300
 agatcaggct gggactctta aggggtgggg gacgtggggc cttcagtgct ttatccccta    360
 ggaaagggtg cacgttatcc caagggagcc cccaggaagt ggggagggag gggggaggag    420
 catgtctagg tgctgaccac ctggagcact tggccagcaa gtgggccgca tgctttggga    480
 gcaatgggtg acccagcagg aagcacaaaa gaccggccag tgtgccatca tcaagggctg    540
 ctgagcagct tgaagagcca ctgggtgggg agggcacacg gggaggtctc agctggggct    600
 gcccctggag gacagggcag ggaacttgag ggctgaggac agaaatctca catgactcca    660
 ggaaatagag gaagaggagg atgctgagcg agggattgtg agggagtggg ggtaggtcag    720
 agggggctga actgcaggaa gccaggggga gtcgtggacc actggagctg gccagcccca    780
 gggcattggg gacaaggcca ggtcagaggg agacagtgtg ggcctggtgg gtggaccctg    840
 gcagaggccc tcttgtcccc cacaaggcca ggccacactg tgattctgcc tgtacctgag    900
 catctgtcct gtgctcctag gccggagacc actgtgtgtc aggtggggcg gttggctgag    960
 tcccagagaa aaacactcct cactgggcac tcttgatgct tgcacacacc ctgtggttta   1020
 tttggtggtc agtaaggaac gtctttgctg ctaagtggaa gaaagctaat ggaacgtaat   1080
 caaaatagtg gtttaattga cgaattttac ttgcacctgt gccttcttca gatcctacct   1140
 gcctacttag tttacgtgaa ggccgactgc accatgcccc ccaaccccga cccccaccac   1200
 acacaacggg gccattgtca tgctaggtgc ttgctttccc cacctcagct ccggagatgt   1260
 gatggtcttt ggctctggag gtctcggcca gcctgtcctc catcctgttc tcgttctcgg   1320
 gcaccaccag cagccggtgc tgggttttgg ctccaagctt gtggtcgggc cggtggtcgg   1380
 gcctcaagcc tgtcttggtg tccagtttgc actcagcgcg gtacttgccc tccccctccc   1440
 tcttgaagga ggcagaagac gtggcttttg ggcttggggg gctgcagcca cgagtggctt   1500
 aggatctcat cgatgtggag ccgcttggct gacgtcgggc ctgcagcatg cggtagatga   1560
 ggtccttgca ctcgcaggtc aggttcttgg agcgcgggaa gtccacacgg tgctccttct   1620
 ggatacgcag catcttcctg atgtcggagt cgtcataggg catggagccg cagaccatga   1680
 tgtacaggat cacgcccagg ctccagatgt catacacctt gggctggtag gggatgctct   1740
 gcagcacctc gggggctgca tatgctgccg acccgcagaa ggtcttgctg aggatgatgc   1800
 gcccattgct gtcccgcagg cagcgcttgg agaagccaaa gtcagacagc ttgatgttga   1860
 agtccttgtc gaggagaagg ttctcgcact tgaggtcccg gtggacgatg tccaggtcgt   1920
 ggcagtactt gacggcggag gagagctgtc ggaacatctt gcgtgccacg tcctcatgca   1980
 gggctccctg gcacttgatg aactcgagga ggtcgccctg gacgccaagc tccatgatga   2040
 tgtagatccg tccgtcagag gtctcaaaga tctcgtaagt cttgatgatg gagccgtggt   2100
 tgacagttgc caggatgtcc atctcccgag gaaggaatct ctccacaaag tcagtagggg   2160
 ttttcttgcg ggcgatgatc ttgacagcca cattgaactt gaggcgctca gagtaggcag   2220
 atttgacttt tgcgtaggaa cccttgccaa gattgatgcc tacgatgtaa cccttcttcc   2280
 ttaggactgt ggcatcgtcc atggtgccag gagcgactgg cgccgctgcc gtctacatcc   2340
 ccccgtcatg tgggccagca ggcattgtcc tcatttacac taccggaggc gtctggctgg   2400
 gctgccctgg gctgggcttc gactcagggg tggaacactc agcattgtct ccgggtgact   2460
 tcagccaatg aactcataaa gccaaggagt gggggcgggg actgggctga gggagaacag   2520
 ggtctctgga accgtggaag ccaggctggt ctggcaggag cacccactcc ccgcccgctg   2580
 gaaggaagcc tgtccccagg acaggactct ggtggccctg ctgctgctgc attggtttcc   2640
 ctgtcacaag tcaagctgga ggggaggcgg cccacgtcca gcctgtttgc atcacctggc   2700
 tgtggggact gaccctgcat tggtctttgt cccactaggg tgggtttcct gcagcttctt   2760
 tggctatgaa gaaaagcacc cccagggctg tgtccttggt gtggtaggac agttgtccct   2820
 gacagtcacc cagacaggcc tgcatagcac cccagttaca cagacagatt tccacagcac   2880
 tgccttacca ttgagcacat agttaaatct agggaaatca gtgcccagac atcaaagcta   2940
 gaaatgaaac atggtcagca ggagccttgc atgggcttct cttttgctgg agcaagccaa   3000
 aataatagga acggttttac attcctagtg ccaggaccca tctcgggtcg acaaaatctg   3060
 aagacaagtt aagggaacag gcagctgttt gaatagatca attggatagt ctaaggcagc   3120
 tctctggacc aagctgtaaa ggagatacaa tcgaaataat cactccggta ccacagtaga   3180
 caggccttga aggcactggg ccccttttaa tcggacttag caagcatttt ttttgcctct   3240
 gaccttctcc ttggaacaaa attagttacc gagtagactt aggtgattgc tgtactgcat   3300
 gtaggcacat aaccccaacc tatataaaca gtaagaaaat tgtagcactt tgagttggtc   3360
 tgctggaatt atctccagcc ttctccctgt atccagttac actgactaaa ctcccttctc   3420
 tcctacac                                                            3428



      <210> 1503
      <211> 597
      <212> DNA
      <213> Homo sapiens


      <400> 1503
 atgttctcac tcactgatag gctggatgtg gatagcttgt ttagcaacat tgagtccgtg     60
 catcagatat cagccaagct gctgtcattg ttggaagagg ccacaacaga cgtggaaccg    120
 gccatgcaag taattggtca gtgcggaggt ttgggggaca cccagatgca acagttggaa    180
 gatcagaatg caaatgttag aagtaatagg aaagctgtcc gctttggaga aaatgacaat    240
 ggggaaatgg tattttcagg atcaaggata caccaatcct cacaagaaag aaaaaatcag    300
 caggaagcag agctgtacgg cagctctgct ccacaaggtg ctctgggatg caacctcctt    360
 ccagctcaca gctccactca ccaagaggtg gctgttatct tcatggacaa gattttctat    420
 gcagttcatg cttttcaagc acggagtgac catgaactca gccttcagga ataccagaga    480
 gttcatatac tcaggttttg tgacctaagt ggcaataaag agtggtggtt agctgaagct    540
 caagggcaga aaggatacgt gccagctaac taccttggaa agatgactta tgcttaa       597



      <210> 1504
      <211> 390
      <212> DNA
      <213> Homo sapiens


      <400> 1504
 gccgggggga tgccatcccc tagcgcgttt cgcgctcggt tgaggcgctg aacaaggggt     60
 tggggctccc gcgcctaagt ttttttttgg ggcgccgcct acctaacaaa cttgggagca    120
 ctcactgacg tgggtagcgc ccagggcctg cggggcgcag gaaagctgga gtcaggcgga    180
 aaccgaaggc tgaccccgca gcggccgggc tgtcgcggcc cccacctaag gtaaccatgt    240
 gcgaccgaaa ggccgggatc aaaaatgcgg acatgtcgga aaaaatgcaa caggactcgg    300
 gggagggcgc tactcaggcg ctggagaaat acaacataaa gaaggacatt gcggctcata    360
 tcaagaagga attggacaag aagtccaatc                                     390



      <210> 1505
      <211> 358
      <212> DNA
      <213> Homo sapiens


      <400> 1505
 attacatgac ctgtgactgt atcattaact gcttttgttt tgcttctgta agtttgccta     60
 taaaaaccac actcagtctt tgttcaatgg tcagcttttc agatacaaat ccactgagcc    120
 ggtgtacatc taaataaatc ctcctgtttc ccgaaaaaaa aaaaaaaaaa aaaaaaaaaa    180
 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaagg    240
 ggggggcctt taaaaaaaac cccggggggg gccccatttt tccggggggg ggaaaaaaaa    300
 ttctttttcc ttaaaggggg ggtattaaaa acccccgggg gattttttgg aaaaaacc      358



      <210> 1506
      <211> 992
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(992)
      <223> n = a,t,c or g


      <400> 1506
 tttcgtggga aggacaaggc cttcacctat gactttgtct tcgacctgga cacctggcaa     60
 gaacagatct attccacctg tgtgagcaag ctcatcgagg gctgcttcga gggctataat    120
 gccacggtgc tggcctatgg gcagacgggg gccgggaaga cgtacaccat gggcactggc    180
 tttgacatgg caacgtcgga ggaggagcag ggcatcatcc cgagggccat cgcacacctc    240
 tttgggggca ttgccgagcg caagcgccgg gcacaggagc agggcgtggc tggacctgag    300
 ttcaaagtca gcgcccagtt tctggagctc tacaacgagg agatccttga cctgtttgac    360
 agcacccgtg accctgacac ccgccaccgc aggtccaaca tcaagatcca cgaggacgca    420
 aacggtggca tctacaccac tggcgtcact tctcgcctca tccactccca ggaggagctg    480
 atccagtgcc tgaagcaggg ggccctgtcc cgcaccacag ccagcaccca gatgaacgtg    540
 cagagctcac gctcccacgc catcttcacc atccacctgt gccagatgcg catgtgcacc    600
 cagcccgacc tggtgaatga ggcagtgact gggcttcctg aatggacacc tccctcgagt    660
 gagtatgaga cactcactgc taaggttcac tttgtggacc tggccggctc aaagcggctg    720
 aagcggacag gggctactgg cgagcgggcc aaggaaggca tcttcatcaa ctgtggcctg    780
 ctggccctgg gcaatgtgat cagcgcctta gggaccagag caagaaggtg gtgcacgtnc    840
 ctacaggact ccaagctcac tcgcttctnc aggattcgct ggggggcaca ggcagaccat    900
 atgaacgcct ggtgaaccct cacacgagat tcatggagaa cctaaacact taatattcca    960
 tcggcccgga cattagaacc aggttagtga cc                                  992



      <210> 1507
      <211> 2379
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2379)
      <223> n = a,t,c or g


      <400> 1507
 atggcagagg tagaggagaa gaagcagcgg atcttccgca agttcaccta ccgcggtgtg     60
 gacctgggcc agctgctgga catgtccttt gagcagctga ggcagctgta cggcgcgcgc    120
 cagctgcggc ggctgaacca cggcctgtgg cggaatgctg aggctcaagc cgcattcgct    180
 gctgaggcgc ctatgctagg ccaagaagga ggcgccgacc atagagaagc aggaagtggt    240
 gaagacgcac ctgcgggata tgatcatccc tcccaagatg gtgggcagca gggtgggcgt    300
 ctacaacggc aagaccttca accaggtgga gatcaagctg gagatgatcg gccacgacct    360
 gggcgagttc tccatcacct acaagcccag cgaggcaaaa aaccaatgaa tcaaccgtta    420
 ctttcggtca ataacctgac ccacctttac gcgccgggca aaggctttag cgatgtctct    480
 tttgatttat ggccggggga agtgctgggc attgtcgggg aatccggctc cgggaagacc    540
 acgctgctga agtcgatctc cgcgcgcctg acgccgcagc agggggaaat tcactacgag    600
 aaccgttcgc tgtatgcaat gagcgaggcc gaccgccgtc gcctgctgcg taccgaatgg    660
 ggcgtggtgc atcagcatcc actcgacggc ctgcgccgcc aggtgtcggc aggcggcaat    720
 atcggcgagc ggctgatggc gaccggggca cgtcattacg gcgatattcg tgccaccgcg    780
 cagaagtggc tggaagaggt ggagattccc gccaaccgga tcgacgacct gccgaccacc    840
 tttttncgcg cgacccatac ggtgaagatg ttctctattc ccggttatag cagtcctggg    900
 caattgctgg atccggaaac gaatatcaac attggcacca gttacctgca atatgtttat    960
 cagcagtttg gcaataatcg tattttctcc tcagcagctt ataacgccgg accagggcgg   1020
 gtcgctaccg ctatcgtcct gacgctctac atcatttata tggtcggttt tttcgctacc   1080
 agtggcgagc tgacatatga agtctggatc ggtttcttcg cctctgcgtt caccaaagtg   1140
 ttcaccctgc tggcgctgtt ttctatcttg atccatgcct ggatcggcat gtggcaggtg   1200
 ttgaccgact acgttaaacc gctggctttg cgcctgatgc tgcaactggt gattgtcgtt   1260
 gcactggtgg tttacgtgat ttatggattc gttgtggtgt ggggtatgcg cgcggcgctg   1320
 caaatttccc agagcggcca gacctgtgcg ctgctctcta aagtcttccc gacccgttcc   1380
 cataccgttt ctgcgcaagg cggcattacc gttgcgctgg gtaataccca tgaagataac   1440
 tgggaatggc atatgtacga caccgtgaaa gggtcggact atatcgatgc tggccggaag   1500
 cgccaggagg aaggtgactg gaacagcgga gtcggggatc cgtccgacgc aggcgatcgc   1560
 aagcaccagc ttaaagcggc tcaattgcgg ccagaagcca taaaacagcg acgcatagcc   1620
 aatcgcctga aacggcgcac tcagttcccg cggcatttga aggggtttgt gaacacccta   1680
 aagcccattc atgggggctg ctcagttggg accaaatgcc ctcaaatggc ctccctccca   1740
 gagggcctgc atcacccagt aaaacttgtg ttcctgggga aaccagggtg cctcctcaca   1800
 gacaggcccc tgaagggtcc caacacagcc aagcctgtgg cggtggatct taatgccagc   1860
 gccacagcga taaccagcta cagcctctat ggcggcagta tgatcctgct gttcctcgct   1920
 tcgacgctct atcacgccat tcctcatcaa cgggcaaaaa tgtggctgaa gaaatttgac   1980
 cattgcgcta tttacctgtt gattgccgga acctacacgc cgtttttgct ggtggggctg   2040
 gattctccgt tagcgcgcgg gttgatgatt gttatctgga gcctggcatt gctgggtatt   2100
 ctgtttaaac tgaccatcgc gcaccgattc aaaattttat ctctggtgac ctatctggcg   2160
 atgggctggc tgtcgctggt ggtaatttat gaaatggcag ttaagctcgc ggcgggcagc   2220
 gttaccttac tggcggtagg cggcgtggtt tattcgctcg gggtgatttt ctacgtctgc   2280
 aaacgcattc catacaacca tgccatctgg cacacagtta ccgccgagca cgaagattat   2340
 cgaaatgcta ttttttatct atttgatttt tatgattaa                          2379



      <210> 1508
      <211> 343
      <212> DNA
      <213> Homo sapiens


      <400> 1508
 caatctctgc caagttttta ttccttttct ctttcattcg cttctttatg tcttcaagac     60
 tatcttgaaa ggactttttc aggcatcttt ccttggccat cttttgcttc ttcctctttc    120
 agggactcca ggaaggccgg ggggaggtgg ggctggcgga agtggacgcg gcgaccctcc    180
 tgccgcaggc gcgtccagaa cgataccttg gccactactt ctgcaacagc tatcttcctc    240
 ctcctcacat ttcaaggctc ttcgaagctc tccagccacg gctagccccg cgcactgggc    300
 cctccaggac cgtaccaccg tccgccgtcg cctggaacta ccg                      343



      <210> 1509
      <211> 759
      <212> DNA
      <213> Homo sapiens


      <400> 1509
 atggtgcagg agaagaacac ggccggagca ctgggtttgt taacagagct tcagaatgtt     60
 ctggaattac tgcggtccac aggaactgga atgttactta atgttagtct caagcagagt    120
 gcagatgaag aagttacatc tttagcaaag tctctcgtca aatcctggaa aaagttacca    180
 gataagccat caagtgagaa agaccctaaa gaaaagcaaa tagaacctgc aatgacatcg    240
 cagaatagca aaagaaacac ttctgattct gtgcggatga agtacaggga gatgcttcct    300
 gcagcccttc gaacaggaga tgactgcatt gaaatgggaa ctgatgagga agaattagga    360
 tctcgaactg aggaagcaat agatccagaa agagggaata caggcatgaa gtacaaaaat    420
 agagtccaaa gtaagatatc aaatcttaca gatgcaaaga atccagattt aaggaaaaat    480
 gcaccgtgtg ggaatattcc tcctgactta cttgctagaa tgacagcaga agaaatggct    540
 agtgatgagc tcaaagagat gcacaaaaac ttgaggaaag aagccatcag agagcatcag    600
 atggccaaga caggtggaac ccagcctgat tcgctcacat gtgccaaatg taaaaagaag    660
 aattgcactt ccacacaggt acaagcctgc agtgctggtg aaccaatgac aacgtttgtt    720
 gactgtaatg aatgtggaaa tcaacagaag ttctgttga                           759



      <210> 1510
      <211> 1419
      <212> DNA
      <213> Homo sapiens


      <400> 1510
 aatagtttca ccagtagttc cgagtttgtt atacatcaga gaatccacac tggggagaaa     60
 ccgtatgagt gtaatgagtg tggcaaagct tttgttggta attcaccctt acttcggcat    120
 cagaaaatcc acactggaga gaaaccctat gagtgtaatg agtgtggcaa aagctttgga    180
 aggacttccc atctaagcca acatcagcgt attcacacag gggaaaagcc ttattcttgt    240
 aaagtatgtg gacaagcctt caattttcat acaaaactaa ctcggcacca gagaattcac    300
 agtgaggaga aaccctttga ctggtgtaga ttgtggaaaa gccttcagtg ctcaggaaca    360
 attaaaaagg catctgagaa ttcatactca ggagtcttcc tatgtatgtg atgagtgtgg    420
 aaaagccttg actagcaaaa gaaatcttca tcagcatcaa agaatccata ctggagagaa    480
 accctatgag tgtagcaagt atgagaaggc ctttgggact tcttccccag ctaggtcacc    540
 ttgagcatgt ctactctgga gagaagcctg tgctggacat ttgtcgtttt ggcctcccag    600
 aattttttac ccccttttac tggtaatagt acactccagt gaaatgtact gagtggattc    660
 cgtcttctac tcaggaatgg aatgtgtgac acaggcctga ctcagcctct gatccatccc    720
 tcaagccaca gttaatgatt cagatgtcag tagatgacca aagatggttc aattagagtc    780
 ccaggattgc aagagctaat aggaacaaat actctccccc cgcccacccc cattggtttt    840
 aatgctgaga agaagaacta gactcttaca gaggtgagaa tgaagtccac acagcaaaaa    900
 tgcatctgag aattggagag cagtaaaaga ctgaagataa tgtttgaaca gccacataca    960
 ccatgcctga agctaaaaat atatacgggt ttttgaattg cagcagccaa taaattccat   1020
 ttttgtttgg ttggttttgg ctttggcaca cctgagttag gttttcttgc cttggaacag   1080
 aattttgact taaacagtgt tgtcattgta gcagttgttt gaagttttca gggataacat   1140
 acctgatgga gaaatgtttt gtgtgtatga tataagggaa agtctttagt tatagtcatg   1200
 gcagctcctc aaccccatga ttgtgatgag attgggaagc ccactgtaac actggagagc   1260
 ccaggttata tcagacacca ctagtagata gaagttctaa caacttgagc tctgtaacaa   1320
 aaatctcatt gtactacaaa attatgtctg caccagtgaa tccattctca agaaaagtct   1380
 taactaggaa actaaaagct ttcactctta aaaaaaaaa                          1419



      <210> 1511
      <211> 382
      <212> DNA
      <213> Homo sapiens


      <400> 1511
 aatagacagg ctacgcctgg acaaatacta tatgctgatt cgtctggtcc tgaggcagtc     60
 ctttgaagtc ttgaagcgaa atggctggga agaaagccga atcaaggttt tcttggatgt    120
 cctgatgaag gaggtcctgt gtcctgagag tcagtctcct aatggagtga gattccactt    180
 cattgatatt tacctggatg aactctccaa agtcgggggg aaggagcttt tagcagatca    240
 gaatctcaag tttatcgatc cattctgcaa aattgctgca aagacgaagg accacaccct    300
 ggtacagacc atagctcggg gtgtcttcga agctatcgta gatcagtctc cttttgtgcc    360
 tgaagagacg atggaggaac aa                                             382



      <210> 1512
      <211> 3531
      <212> DNA
      <213> Homo sapiens


      <400> 1512
 tcactgtggt tttgatttgc atttctctga tggccagtga tgatgagcat ttttcatgtg     60
 atttttggct gcataaatgt cttcttttga gaagtgtctg ttcatgtcct tcacccactt    120
 tttgttgggg ttgtttgttt ttttcttgta aatttgtttg agttcattgt agattctgga    180
 tattagccct ttgtcagatg agtaggttgt gaaaattttc tcccattttg taggttgcct    240
 gttcactctg atggtagttt cttttgctgt gcagaagctc tttagtttaa ttagatccca    300
 tttgtcaatt ttggcttttg ttgccattgc ttttggtgtt ttagacatga agtccttgcc    360
 catgcctatg tcctgaatgg taatgcctag gttttcttct agggttttta tggttttagg    420
 tctaacgttt aagtctttaa tccatcttga atttgatttt ttgtataagg tgtaaggaag    480
 ggatccagtt tcagctttct acatatggct atccagtttt cccagcacca tttattaaat    540
 agggaatcct ttccccattg cttgtttttc tcaggtttgt caaagatcag atagttgtag    600
 atatgcggcg ttatttctga gggctctgtt ctgttccatt gatctatatc cctgttttgg    660
 taccagtacc atgctgtttt ggttactgta gccttgtagt atagtttgaa gtcaggtagt    720
 gtgatgcctc cagctttgtt cttttggctt agaattgact tggcaatgca ggctcttttt    780
 tggttccata tgaactttaa agtagttttt tccaattctg agaggtgaca ggttctaact    840
 gcattttcca ccagcttccg gaacactagg aggaccttgg caggcacaat gtctccgtcg    900
 atgttcacat ctgtctcatg ccactgccac aggctcttca taaactgttc cacctccagc    960
 cactgctgca gaccctcagg gtcccgcaac gggcagggca gcctggtgcc ctgcagtgtg   1020
 tagtaccgcc agtgctgctc cctggcctcc ctgtacccgg ccaggccttt tattgggact   1080
 gtgacgagga actgactggg agccaaaacc tcctgaacat ggtggcagct ggcaccaggg   1140
 aactccatag tcagaacact ttttgtctgt attcctgcaa gctctaggtc tgacacagat   1200
 gtcataagac aagtaagacc atcacattcc cactgagcat tgttcgaagt gccggagata   1260
 taatacaaca gtgaataaga caagccctct cccggcatag agtttatatt tattctaata   1320
 ggagaaccag caaaccataa tgtgccaggc tgtgtcctca gctctaaaga tacaaccctg   1380
 aaaatgcaga taaagcccct tctcgtggag ccttcacctt gggggtcagg ttgacccttg   1440
 ttttgttgga actgcttgtg aagcatcagg tggtggcatt tcataggaac cgcctgcagt   1500
 gcacaggaag gccggactgg agctctacat gtgagcatat ttggaatgtg gatagtactg   1560
 gaaaccacag gagtggctaa aattgctagg ctgagtgagt agagtcgcgg ggcagggctc   1620
 aggacctgca gcccgccatg cccgagcctc tccgcctccc ccctgtgggc tcctgggcag   1680
 ccgggagcct ccccagtggg agctgtcccc tgctctgtgg tgcccagtcc catcgaccgc   1740
 ccaggggctg agcagtgcag gcctgcccgc aaagccagca aggctcctga gtcgggagga   1800
 gacttggaga acttttatgt ctggctggag gattgtatat gcaccaatca gcactctgtg   1860
 tctagctctg ggttcatgta tgcaccaatc agcactctgt gtctagctaa tctggtgggg   1920
 acttggagaa cttttgtgtc taactcaggg attgtaaacg cattaatcag caccccgtca   1980
 aaacggacca atcagctttc tgtaaaatgg accaatcagc aggatgtggt gttggaagtt   2040
 ctggccaggg caattaggca ggagaaggaa ataaagggta ttcaattagg aaaagaggaa   2100
 gtcaaattgt ccctgtttgc agacgacatg attgtatatc tagaaaaccc cattgtctca   2160
 gcccaaaatc tccttaagct gataagcaac ttcagcaaag tctcaggata caaaatcaat   2220
 gcacaaaaat cacaagcatt cttatacacc aacaacagac aaacagagag ccaaatcatg   2280
 agtgaactcc cattcacaat tgcttcaaag agaataaaat acctaggaat ccaacttaca   2340
 agggatgtga aggacctctt caaggagaac tacaaaccac tgctcaagga aataacagag   2400
 gatacaaaca aatggaagaa cattccatgc tcatgggtag gaagaatcaa tatcgtgaaa   2460
 atggccatac tgcccaaggt aatttacaga ttcaatgcta tccccatcaa gctaccaatg   2520
 actttcttca cagaattgga aaaaactact ttaaagttca tatggaacca aaaaagagcc   2580
 cgcatggcca agtcaatcct aagccaaaag aacaaagctg gaggcatcac actacctgac   2640
 ttcaaactat actacaaggc tacagtaacc aaaacagcat ggtactggta ccaaaacaga   2700
 gatgtagatc aatggaacag aacagagccc tcagaaataa cgccgcatat ctacaactat   2760
 ctgatctttg acaaacctga caaaaacaag caatggggaa aggattccct atttaataaa   2820
 tggggctggg aaaactggct agccatatgt agaaagctga aactggatcc cttccttaca   2880
 ccttatacaa gaattaattc aagatggatt aaagatttaa acgttagacc taaaaccata   2940
 aaaaccctag aagaaaacct agacattacc attcaggaca taggcatggg caaggacttc   3000
 atgtctaaaa caccaaaagc aatggcaaca aaagccaaaa ttgacaaatg ggatctaatt   3060
 aaactaaaga gcttctgcat agcaaaagaa actaccatca gagtgaacag gcaacctaca   3120
 aaatgggaga aaatttttgc aacctactca cctgacaaag ggctaatatc cagaatctac   3180
 aatgaactca aacaaattta caagaaaaaa acaaacaacc ccatcaaaaa gtgggcgaaa   3240
 gacatgaaca gacacttctc aaaagaagac atttatgcag ccaaaaaaca catgaaaaga   3300
 tgctcatcat cactggccat cagagaaata caaatcaaaa ccacaatgag ataccatctc   3360
 acaccagtta gaatggcaat cattaaaaag tcaggaaaca acagttttct gatggcagaa   3420
 gcctggccca tctggttaag ctctccgttc ctggaaggag gacatagcag ggacttcata   3480
 cgtggggatg aatcaatgtc aaatgaggaa aaatacaaag accttaatta g            3531



      <210> 1513
      <211> 883
      <212> DNA
      <213> Homo sapiens


      <400> 1513
 tcagatgtga ccttcctggt ggaaggaaag ctgttttatg cacataaagt cctgctggtg     60
 acagcttcta acaggtaggc agcctcagat aacaaactcc cagcccaggg gcacagaagc    120
 accttgtttc agattccagg tgacagagag tgactcgctg gggctgtacc ctgcagcctc    180
 tgcccctcag actgcagtca cattgcagca gagccccact cgccccacag cgggatgaga    240
 cggggtggac ccagggcagc aggaaagggg ggctctgagg tggtgttctt tctggcctag    300
 ttattgcttt tattattaga aaacataaat atcctggaat gaagagtcag cattctggcc    360
 acaggcgtca ggtcgcttgt agggtgggtg gtggggacag aattgggctc agctcagatg    420
 tcttcctaag atggtgtaaa atggcacttg ctgaaaatta ttttaggagc acagcagtaa    480
 tttttaaaat gttccgtctt gtggtagccg gtcaggtgac agatggtgcc atcgccacac    540
 agtggtgaag taaaaggttc aaaacccacc ttgctttgtc tcctttgctc caggttcaag    600
 acactaatga ccaataaatc agaacaggat ggggacagca gcaagaccat cgagatcagc    660
 gacatgaagt accacatttt tcaggtgtgt gggtcttggt gccgccctct tctcagaggg    720
 atgaccctcc cccaggagcc caccttgtgg gcagctgtgc attggttgtc attgttcact    780
 ctattcccag tgccttctgt attctgttga atgaatagag catccaggtc tttccctgtg    840
 cagaggtagc catccgttgt ggggctgcag cttcagagcc tgt                      883



      <210> 1514
      <211> 335
      <212> DNA
      <213> Homo sapiens


      <400> 1514
 ggcacgagat taccattcag gagaaaacct ctacttgccc tgcttcgcgg actctaaccc     60
 accagcagaa tattcttgga caattaacgg gaagtttcag ctatcaggac aaaagctctt    120
 tatcccccac attactacac accatactgg gccctccccc gctctgatcg caactcaccc    180
 actggcatgc aaagctccaa attcatgaca gtcaacgcct ctgctccttc acgaccatga    240
 catcttcctg gccttaatcc attatagtac ccgtgacccc ctctctcgct ctcatgaata    300
 ctgccccaca gccgctttca ctcttcctcc aaccg                               335



      <210> 1515
      <211> 335
      <212> DNA
      <213> Homo sapiens


      <400> 1515
 ggcacgagat taccattcag gagaaaacct ctacttgccc tgcttcgcgg actctaaccc     60
 accagcagaa tattcttgga caattaacgg gaagtttcag ctatcaggac aaaagctctt    120
 tatcccccac attactacac accatactgg gccctccccc gctctgatcg caactcaccc    180
 actggcatgc aaagctccaa attcatgaca gtcaacgcct ctgctccttc acgaccatga    240
 catcttcctg gccttaatcc attatagtac ccgtgacccc ctctctcgct ctcatgaata    300
 ctgccccaca gccgctttca ctcttcctcc aaccg                               335



      <210> 1516
      <211> 4228
      <212> DNA
      <213> Homo sapiens


      <400> 1516
 gtgaaccata tatgtttcat catcatggag atcttggaga attatctgag caccaggttc     60
 atatgtattc gatctcagag gcatctattg gacaacaaaa cactctttca gttctttggg    120
 gtctctactt aggagtggaa tttctaagtc atcatgtaac tgcatttaat ctttccttgc    180
 tttctttagc caactttgct gacagatacc taagtgtagt gtctaggggc tgactgccgg    240
 gagacggagc caggctgtgt agaggggatt ggctttgggg aacttgcttt gaccacagca    300
 cgtctatgtt gacctggacc cacatttgct ccaatccaca ttcctgggga gggtggttct    360
 cctgtattga ctgttttcct tcaggtgctt ggatgaagct gaaaagacac taagaccttc    420
 tgtgcctcag atccctgagt gcccgatttg tgggaaaccg tttcttacct taaagagcag    480
 aaccagtcac ttgaagcagt gtgctgtgaa gatggaggtt ggcccccagc tcctgcttca    540
 ggctgtgcgg ctgcagacag cacagcctga gggtagcagc agcccaccca tgttcagctt    600
 cagtgatcac agtagaggtc tgaaacggag aggacccacc agcaagaagg agccacggaa    660
 gaggcggaag gtggacgagg caccgtccga ggacctgctg gtggccatgg ctctgtcccg    720
 gtcggagatg gagccgggtg cggctgtacc agcgctcagg ctggaaagtg ccttttctga    780
 gaggataaga ccagaagcag gtttgtgtga tcagaagagt gaccctggga gaggccatca    840
 gcaggtcccg gagaataaaa gtcgcaagaa gaaacccccg gtatcccccc cattgttgtt    900
 agtccaggac tctgaaacca caggccgaca gatagaggac cgtgtggccc tgctcctctc    960
 tgaggaagtg gaattgtcta gcacgccacc acttcctgcc agcaggattt taaaggaagg   1020
 gtgggaaaga gcgggccagc gacctcctcc cacctgaacg caagcaaagc tttctgtggg   1080
 agggcagcgc actgactggg gcctgggcca tggaggactt ttacacggcc aggctggtcc   1140
 ctcctctcgt gccccagcgg cctgcccagg gccttatgca ggagcccgtg ccgcctctgg   1200
 tgccacctga gcactcagag ctgagcgagc gaaggtcacc cgctctccac ggcaccccca   1260
 ctgcaggctg tggctccagg ggcccgtcgc cttcggccag ccagagggag caccaggccc   1320
 tgcaggacct cgtggacctg gcgagggagg gactgatgcg ccagcccgtg gcccggcagt   1380
 gggggcctgg ctggctcgga agggactgca gggttggacg tggtgcccgg cggccttcct   1440
 ctgactgggt ttgtggtgcc atcgcaggac aagcacccgg acaggggcgg ccgcaccttg   1500
 ctctccctcg ggctgctggt tgctgacttt ggcgccatgg tcaataaccc acacctgagt   1560
 gatgtccagt ttcagacgga cagcggggag gtgctttacg cccacaagtt cgtgctttat   1620
 gcccgatgcc cgctcctcat ccagtatgtg aacaatgaag gcttctccgc tgtagaggac   1680
 ggggttctga cccagcgtgt cctgctgggt gacgtgagca ccgaggccgc ccgcacgttc   1740
 ctgcactatc tctacactgc ggacactggc cttcctcctg gccttagctc tgagctgagc   1800
 tccctggccc acaggtttgg cgtgagtgag ctcgttcacc tgtgtcgaac aggtgcctat   1860
 tgccactgac tcagagggca aaccatggga ggagaaggaa gcagagaatt gcgaaagcag   1920
 ggccgagaat ttcccaggaa ctcttgaggt caatgtgggc agatgaagag gaggaagcga   1980
 agactttgtt gaaatccaag gaccacgaag aagatcaaga aaacgtgaat gaagcagaaa   2040
 tggaagaaat ttatgaattt gcagctactc agcgaaagct tctccaggaa gaaagggcag   2100
 cgggtgccgg cgaggacgct gactggctgg agggtggcag tccggtttct gggcaactcc   2160
 tagcaggtgt ccaggtgcag aaacagtggg acaaggtgga ggagatggag ccgttggagc   2220
 caggaagaga tgaggccgcc accacctggg agaagatggg acagtgcgct ctcccgccac   2280
 cccagggcca gcactcaggg gcacggggag cagaggcccc tgagcaggag gcgccagagg   2340
 aggcgcttgg ccattccagc tgctccagcc cttccaggga ctgccaggca gagagaaaag   2400
 aaggctctct tccgcactca gatgatgccg gggattacga acagcttttc tcatcaactc   2460
 agggagagat ctcagagccg tcccaaataa caagtgagcc cgaggaacaa agtggcgctg   2520
 tcagggaaag ggggctggag gtttctcatc gcctggctcc ctggcaggca tctccaccgc   2580
 acccgtgccg cttcctattg gggcctcccc agggcgggag tccccgcggg tctcatcaca   2640
 caagtgggtc gtccctgtca acaccccggt cccgtggcgg aacttcccag gtgggctccc   2700
 caaccttgct gtctccagct gtgccatcaa agcagaaaag ggacaggagc atcctcacgc   2760
 tgtctaaaga gccagggcac cagaaaggca aagagcgtcg gtccgtgctg gagtgcagaa   2820
 ataagggggt cctgatgttc ccagaaaaat ctccgtctat tgacctaacc cagtcaaatc   2880
 ctgaccattc gagctccaga tctcagaaat cttcatccaa actgaacgaa gaagatgagg   2940
 tcatcctctt actggactcg gatgaggagc tggagctaga ccaaaccaaa atgaagtcca   3000
 tttctagtga tcctctggaa gaaaagaaag ctctagaaat tagccctagg tcctgtgagc   3060
 tgttttccat cattgatgtt gatgcagatc aggaaccttc ccagagccca ccaagaagcg   3120
 aagctgtgct gcagcaggag gatgaggggg cgctgccgga gaatcggggc tctttgggca   3180
 ggagaggggc tccctggctg ttctgtgacc gtgagagcag ccccagcgag gccagcacca   3240
 cagacacctc gtggctggtg cccgccaccc cgctggccag cagaagccgt gactgttctt   3300
 cccagaccca aatcagcagc ctcaggagcg ggctggccgt gcaggcggtg actcagcaca   3360
 cgcccagggc ctcagtagga aacagggaag ggaacgaagt cgcacagaag ttttctgtca   3420
 tcaggcccca gacaccaccg ccccagacac cgtcctcatg cctcactccc gtctctccag   3480
 gaacttctga cggcagaagg caaggccaca gaagcccttc ccgtccccac cccgggggcc   3540
 acccgcactc ctctccgctg gctccacatc ccatctcagg ggaccgcgcc cacttcagca   3600
 ggcggttcct gaaacactcg ccgcctgggc caagcttcct gaaccagacc ccagcgggtg   3660
 aagtggtgga agtcggagac agtgacgatg agcaggaggt ggcctcccat caggccaaca   3720
 gaagcccccc actggacagt gaccccccaa ttccaattga cgactgctgc tggcacatgg   3780
 agcccctctc gccaattccc attgaccact ggaacctgga gcggaccggc cccctgagca   3840
 ccagcagccc cagccgcagg atgaacgagg ccgccgacag ccgtgactgt cgctccccgg   3900
 gactcctgga caccaccccc atccgaggaa gctgcactac ccagaggaaa ttgcaagaga   3960
 agtcctcggg cgcgggctcc ctggggaata gcaggccgag ctttctgaat tcggctctgt   4020
 gggacgtttg ggacggggaa gagcagaggc ctccagagac ccctcctccg gcccagatgc   4080
 caagcgctgg tggagctcag aagcccgaag ggttagagac acccaaaggt gctaatcgga   4140
 agaagaactt gccccccaaa gtgcccataa cgccgatgcc acagtattcc attatggaga   4200
 cgccggtgct gaagaaggaa ctggatag                                      4228



      <210> 1517
      <211> 284
      <212> DNA
      <213> Homo sapiens


      <400> 1517
 gaatgggata ccagatttca gcaatacaac ccttctgaga gggcttcaaa tgcctggagc     60
 aagaggtcct tgctgtgggt cccagagaca catcaacctt ctgatgggga ctggcgtctt    120
 cctggtgaag atgaaggcaa agagttcttt ttcctggaca gtgaaaccag attgtgcaaa    180
 atagctcctg aaggctggag agagcagcct cagaagacct ccatgaatac cttcacactc    240
 ttcctgagga taaagttctt tgtcagccac tatgggctgc tcca                     284



      <210> 1518
      <211> 755
      <212> DNA
      <213> Homo sapiens


      <400> 1518
 tttcgtgggc acagcagcca ggctgccgga gagctgatct cggggattcg ggtgcggagc     60
 ccttggcctg gaggcgatat gggtggtccg tggcccggtt cagtcgcttg cagcagcccg    120
 gggaacaggc ctgtctggcc ctgagggagt cccctttctg aagctgtggt gcttggacga    180
 cctgctctct acattgctgg gcacctgtag gtgtccctcg agagctcagt tttgaggttc    240
 aagtcagtgt ggccatgaag gggctgccta ttgggctgat gctgtgaccc tggagtctgc    300
 ctctcctgcc agtccccctg cccggaacat gtggctgcgg cttggcccgc cctcgctgtc    360
 cctgagcccc aagcccacgg ttggcaggag cctgtgcctc accctgtggt tcctcagttt    420
 ggcgctgagg gccagtaccc aggccccagc acccacagtc aacactcact ttgggaagct    480
 aaggggtgcc cgagtaccac tgcccagtga gatcctgggg cctgtggacc aatacctggg    540
 ggtgccctac gcagctcccc cgatcggcga gaaacgtttc ctgccccctg aaccaccccc    600
 atcctggtcg ggcattcgga acgccacaca ctttccccca gtgtgccccc agaacatcca    660
 cacagctgtg cccgaagtca tgctgccggt ctggttcact gccaacttgg atatcgtcgc    720
 tacttacatc caggagccca acgaagactg tctct                               755



      <210> 1519
      <211> 687
      <212> DNA
      <213> Homo sapiens


      <400> 1519
 gcccgttcca gtagaaaaga cagctttgct cctttgaaag cgcagaccgc cgcacctcca     60
 gccccttctc cccggggaag taggccccgc taagaatgtg ggaaggtggt ggggcggcga    120
 ctgaagtcgc ttccgattgg cgttgtccca aggaagcctg cgcggagttg atcggcggca    180
 ggcttcccaa taagagcctg ctaaggggaa ttggctgcta cgcggctggg gcccttgttt    240
 ccggttacct aggcgggcag ccatggtgac cggcgagcgg catgcgacgc cgcctctgtg    300
 gcctgtggag gcccgcttgg cggcgctgct tcccgaccta ctggtctttc ggaagcctcg    360
 gggatgggaa cccgagctcg ccacggccca gggcgtcctc ctaggcgtcc atgtgacggg    420
 tgagggcgac ggccggcact tgcacttaag tctcctggcc tgcgggagag gcggccgttg    480
 ggtctaacat atcttcagtt attacattag tgacatcgtg gagcgtgagt gatcattgta    540
 gggtaacaag gtgtggtgct gggctcctgg gggtttataa aagaaggggg ccgggcaggt    600
 tgtagtgatg tccagttagc tcagcgtttg gctcaggcga atgaaattgt cctatcctgg    660
 aactgctgga tgctttgcaa gcagtat                                        687



      <210> 1520
      <211> 932
      <212> DNA
      <213> Homo sapiens


      <400> 1520
 cagctttgtg tgtgaagttg gcctaggtaa ctcatcttct aatatgaaca tcagaggtga     60
 cactggacac aaggcatgtg aatgtcagga atatggacca aagccatgga agagtcaaca    120
 acctaaaaaa gccttcagat atcacccctc cttgagaaca caagaaaggg atcacactgg    180
 aaagaaaccc tatgcttgta aagaatgtgg aaaaaacatt atttaccatt caagcattca    240
 aagacacatg gtagtgcaca gtggggatgg accttataaa tgtaagtttt gtgggaaagc    300
 attccattgt ctcagtttat atcttatcca tgaaagaact cacactggag agaaaccgta    360
 tgaatgtaaa caatgtggta aatcttttag ttattctgct acccatcgaa tacatgaaag    420
 aactcacatt ggagaaaagc cttatgaatg tcaggaatgt gggaaagcat tccatagtcc    480
 cagatcctgt cacagacatg aaaggagtca catgggagag aaggcttatc aatgtaagga    540
 atgtggaaaa gcattcatgt gtccccgtta tgttcgtaga catgaaagga cccactctag    600
 gaaaaaactt tatgaatgta agcagtgtgg gaaagcatta tcctctctta caagttttca    660
 aacacacata agaatgcact ctggagaaag accttatgaa tgtaagacat gtgggaaagg    720
 cttttattct gccaagtcat ttcaaagaca tgaaaaaact cacagtggag agaaaccgta    780
 taaatgcaag caatgtggta aagccttcac tcgttccggt tcctttcgat atcatgaaag    840
 gactcacact ggagagaaac cctatgagtg taagcaatgt gggaaagcct tcagatctgc    900
 cccaaatctt caatcgcatg gtaggactca ca                                  932



      <210> 1521
      <211> 1926
      <212> DNA
      <213> Homo sapiens


      <400> 1521
 atggccttca aggaaatcaa gaaggctttg atccacgccc tggcattagg actgccagac     60
 atgacaaagc ctttttacgt gtatatctat gaaagaaaag gaatatctat aagagtcttg    120
 gtacaaacac tagggtcatg gtattggccc gtggcatgtt tgtcccagcg actagacttg    180
 gtggctatgg gatggcctcc ctgtttcaag gcagtggcag ccactgccct gttagcagaa    240
 gatgctaaca agctcacatt tggacagagg ttgataattc aggtgcccca tacgatcgtc    300
 accctgatgg ggcagagggg gcatggctgg ctttctaacc ctaggatgtt aagatatcaa    360
 gaacttttgt gtggaaaccc ctacataatc ctggtgactc tgaatactct agatccacgc    420
 acactgctgc caaaagagtg ggcagagcac agaaagcccc cgttgtgttg cccagcccaa    480
 agagttgagc taacagccct cactagagca tcgctcgtgg ccaaaggaaa gtcagtaaac    540
 atctatactg acccaaggtg tgcttttgcc attttgcatt cccatggagc catatgggcc    600
 aacatggccc ccagggattc aagaaactgg actacaccct gtgaaaacct gcctgtggac    660
 tttatcgagc tgcctcaagt tggaggctgc cggtacatgc tagtgtttgt ctgcactttc    720
 tcaagttctg taaaagttga aagaatgaag gagacactca aacagctgtt aaaggttttg    780
 ccaggaaact tatctaaggt gaaatcagga gctgcccatg gtccttctgt gagtcagagg    840
 caccctacta aattaactgg gtattcaccc tatgagatgg tgtttggctc accacccaca    900
 atcataactc agataaaagg ggatttaaaa gaaattgggg aattaacctt aagaaggcaa    960
 atgcaagcct taggtgaggc catgcaggaa atacaaaggt atcacacctt gggttcatca   1020
 cagccagctg aaaccagcag cgaccacaac tcaggacccg cggccagtca acaaaaccca   1080
 gactacccaa aacagttgat cctgcggcaa aactatgcca ctgctgacaa ggataactgc   1140
 cctgctctga ccataccgga ggctgaaatc agggtcagta aacctgtaaa caaaaaagaa   1200
 gtattccctc actcgcataa aggccctgtc tccatacatt ttgatgcctg ccaagcttca   1260
 catctcagta aactaaatac tattgggacc atccgtaaaa atctaggaca agaaagagtc   1320
 agccagcaga gctaccaagg ctgtaacagg aaaatccaaa aaggagtgcc ctgattgtga   1380
 taatcagtgg accacacatg aatttatcag cacctataca caggaagggt tgctctattt   1440
 gccagccaag aggtgaagat agggtgcaca actggaactt gcaacccact caatctgaca   1500
 atactaaagc caaatatgcc tttctggact aaagggccta aagggctact aatctttgat   1560
 caggaaagag cactcctagg acttcgtatt cctctggtca ttaccaggaa aacccaaagg   1620
 acccaagttc aagttagccc aatgcaacac tttaggtttt atacatcttt caatgaacac   1680
 tttaatcctg aagtatcaaa aaatcaaatt cctcctatat cagctgaaaa cctgtttgcc   1740
 cagctagccg aaagtactgc taacaattta agagttacta ttccagacat tgtatggaaa   1800
 agcactgtga aaatccctgt cctgttctgt tccattctga ttactggtgc atacagcccc   1860
 ctgtcatgta ccgctgcttg ctcaatcgat cacgaccctc tcacatggac cctcttaaag   1920
 ttgtga                                                              1926



      <210> 1522
      <211> 447
      <212> DNA
      <213> Homo sapiens


      <400> 1522
 ataggaactc gcgtgactgg gaaaacaccg tctgcactgg gaaaccactt cctactttgg     60
 gcttcgaggt caggacttcg agtcgagcac gaggagagag ctaggagctt cactaccctg    120
 atgggtatgg cgacgcccac aagggttagg acaatcctct gatctgacat ggagatataa    180
 tgttactgct aaatcagaca ctaacgccaa atgagagaag tgccatcata actgcagccc    240
 gagagtttgg cgatctctgg tatctcaggt caatgatagg atgacaacag aggaatgaga    300
 acgattcccc acaggccagc aggcagttcc cagtgtagac cctcactggg acacagaatc    360
 agaacataca gattggtgcc gcaaacattt gctaccttgc gtgctagaag gactaacgaa    420
 aactaggaag aagcttatga attattg                                        447



      <210> 1523
      <211> 1139
      <212> DNA
      <213> Homo sapiens


      <400> 1523
 gggaaatctt cccagtgggc agaacttcaa gcagtgtacc tggttgtgca ctttgagtgg     60
 aaggagaaat gaccagatgt gtgattgtat tcagattcac gggctgtagc cagtggcttg    120
 gctggatggt ccgggacttg gaagaagcat gattggaaaa ttggtgatga agaaatttgg    180
 ggaacaggta tgtggatgga cctctttaag tggtcaaaaa ctgtgaagat atttgcatct    240
 cacgtgagtg ctcaccaacg ggtgatccca gcagaggagg attttaataa tcaagtggat    300
 aggatgaccc gttctgtgga caccttcagc ctctttcccc agccacttct gtcatcatgc    360
 aatgcgcctg tgaacaaaat ggccatagtg gcagggatgg agtttatgca tgggctcagc    420
 aacatggact tccactcacc aaggctgacc tggctacggc cactgctgag tgcccagttt    480
 gtcaagcagc agagactaac accaagccct tcgatattgg gcaccattcc ttggtgtgat    540
 cagccagcta cctggtggca ggttgattat attggacttc ttccatcatg gaaacggcag    600
 tggtttgtcc tcactggaat agacacttac tccggatatg ggtttgccta tcctgcacga    660
 aatgcttctg ccaagactac catccgtgga gtctcggaat gccttatcca ccatcatggt    720
 attccacaca gcactgcctc tgaccaaggc actcacttta cagctaaaga ggtgtggcag    780
 tgggcttatg ctcatggaat tcactggtct taccatgttc tccatcatcc tgaagaggct    840
 gcaaagaacg gtggaatggc cttttgaagt cacaattaca atgccaacta ggtgacaaca    900
 ctttgcaggg ctgaggcaaa gttctccagc aggccgtata tgttctgaat tagcatccaa    960
 tatacggtac tgtttctccc atagccagga ttcacggtcc aggaatcaag gggtgaaact   1020
 gaactgacac cactcaccat cacccctagt gatcccctag caaaattttt gcttcctgtt   1080
 cccccgacat tacattctgc tggcctggag atcttagttc cagagggaga aatacgaaa    1139



      <210> 1524
      <211> 1123
      <212> DNA
      <213> Homo sapiens


      <400> 1524
 cgacccacgc gtccgcccac gcgtccggaa gaaataaaaa atttgattct accatatatt     60
 tctgacatga actttgtgca agatttatgt gaagattttt atgaactttt taagactgac    120
 aaaggatttg acaaagccac ttttgaaagt cagatgtctg tgatgagggg tcagatctta    180
 aaccttactc aggcattgag agacgggaag agtcctttcc agctagtaca gataccttgt    240
 gtgattgtgg aacgcagtca aggtggaagt cagggtcgga ttgtccacct gagcaattcc    300
 tttacccaga ctgtcaattg caggaagcca tttttttcct cctggtagta aatgtcagag    360
 taagagaaac aaactgttta gaattatcat gtttttaaaa catcatagta atataaatct    420
 gctgttagga gctccagttg ctaaaacctc aatttaagtc tttaaaaggt tgtattttga    480
 atgtaaccaa aagtttacag ttttttgtcc aaatattaaa tttctatttc agggaagaag    540
 tgctatatct cctatattgt atttttgtag aaaatttgta ttttatgttg ttgttagttt    600
 aaaaggtaat tttacacatg ctggaatgac tgtaattact ctagaattcc aagtagaata    660
 caataacttt taatattgag aagaatgttc atgctaattc ttcttacatt acaaaaggcc    720
 tttgaggatg cctacgtctg aaattgctct tacgaacttt aataaaatag ttagctaata    780
 gaaaaacagg taagaataaa gcaatgttgc cttaatttca aaagctgcta ttttagaatt    840
 tgaataagta ctcctaaagt gaccattatt agggaccaga aaattatatc ttggctaagt    900
 aatagaggac cattttggtt tttgtacttg agaatatttt tggtgaatta ctttgttgta    960
 gtgaggaaaa aacctaagaa atttcccctt tttttaaaaa atggaaatat tcaattgaga   1020
 cttgagggga ataatagaaa attaaggtag atcccccccc aatattttgg aataccaaaa   1080
 ttgccttaaa aattcccttc tgtcgtcttc tcgcagccgt ata                     1123



      <210> 1525
      <211> 429
      <212> DNA
      <213> Homo sapiens


      <400> 1525
 tttcgtagta ctagcagcag tggttcctaa atgaaatggg ctatttctgc ttcattactt     60
 tattattctg agttaaataa acatgggaca taagaggatg atctctgctt tccagggact    120
 gatgtggaaa tggtaaactc agtcttcagt ccactccatg cacatgtatg gagactactg    180
 agggaaacaa gaaggacagc gataaaacat gatcctcctg aagaagagac ggctgcttat    240
 caattcattg ggtgaaggta caataaatgg cttactggat gaattattgg agacaaatgt    300
 gctgagccag gaagacacag agatagtaaa atgtgaaaat gttacagtta tcgataaggc    360
 ccgagatttg cttgactctg ttattcggaa aggggcacgg gcatgtgaaa tttgcatcac    420
 atacatttg                                                            429



      <210> 1526
      <211> 475
      <212> DNA
      <213> Homo sapiens


      <400> 1526
 gttccgccca attggcataa tacgccaagc cctgtgctct gcagacggcc accagagaag     60
 gatccttact ctgcgcctgg gattgctcgt tatcccgttt ctccccgcaa gtaacctgtt    120
 cttccgagtg ggcttcgtgg tcccgagcgt ggggtgctgt gtgatgctgc tttttggatt    180
 cggagcctgc gcaaacacac cgagaaaaag aagctcatcg ctgccgtggt gctgggaatc    240
 ctactcagca agatgctgag aggctgagat gcgcggtgcg cggcggcgag tggcggagcg    300
 aggggcggtt ttcagaggcg ctgtgtctgt gtgtcccctc agtgctgagg ttcgctgcaa    360
 catcggcaga aacctggctg ctaaaggcaa ccaaacgggc gccatcagat accaccggga    420
 agctgtaagc ttaaatccca agacgaaatc gtcgacacgg gaattccggc cttgc         475



      <210> 1527
      <211> 348
      <212> DNA
      <213> Homo sapiens


      <400> 1527
 ggcttactca ctataggctc gagcggccgc ccgggcaggt ttttcgtctt atttgaagtc     60
 attgccggat gtgaggaaaa aatcgcttcc cttgcctgaa aagccacaca aagaagaaaa    120
 ttcagaaatc gtggtttgga gagaatttga caagcaagtg ttcctcttga actgaagccc    180
 ccggagacaa tcgaagctgt acacggtgga cctggagtca gggctacact acctcctgcg    240
 ggtggagctg gcagcccaca agtccctggc cggagcagag ctgaagacgc tcaaggactt    300
 tgtgactgtc ttggccaagc tgttccctgg acggccgcca gtcaagcc                 348




      <210> 1528
      <211> 428
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(428)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1528
 Arg Lys Arg Ala Leu Asp Ala Val Ala Arg Lys Trp Ser Gly Cys Arg
   1               5                  10                  15    
 Ser Ala Ala Pro Ala Val Ala Ala Glu Ala Cys Val Cys Gly Leu Arg
              20                  25                  30        
 Gln Ala Thr Glu Met Ala Ser Ala Thr Ala Pro Cys Ser Arg Ser Pro
          35                  40                  45            
 His Pro Trp Leu Arg Pro Leu Glu Gln Leu Arg His Leu Ala Glu Glu
      50                  55                  60                
 Leu Arg Leu Leu Leu Pro Arg Val Arg Val Gly Glu Ala Gln Glu Thr
  65                  70                  75                  80
 Thr Glu Glu Phe Asn Arg Glu Met Phe Trp Arg Arg Leu Asn Glu Ala
                  85                  90                  95    
 Ala Val Thr Val Ser Arg Glu Ala Thr Thr Leu Thr Ile Val Phe Ser
             100                 105                 110        
 Gln Leu Pro Leu Pro Ser Pro Gln Glu Thr Gln Lys Phe Cys Val Glu
         115                 120                 125            
 Gln Val His Gly Cys His Gln Gly Ile Leu Phe Ala Val Tyr Tyr Leu
     130                 135                 140                
 Leu Pro Lys Asp Gln Gly Ile Thr Leu Lys Lys Ala Gly Tyr Gly Gly
 145                 150                 155                 160
 Ala Thr Leu Asp Ile Val Asp Gly Met Ala Gln Leu Met Glu Val Leu
                 165                 170                 175    
 Ser Val Thr Pro Thr Gln Ser Pro Glu Asn Asn Asp Leu Ile Ser Tyr
             180                 185                 190        
 Asn Ser Val Trp Val Ala Cys Gln Gln Met Pro Gln Ile Pro Arg Asp
         195                 200                 205            
 Asn Lys Ala Ala Ala Leu Leu Met Leu Thr Lys Asn Val Gly Phe Val
     210                 215                 220                
 Lys Asp Ala His Glu Glu Met Glu Gln Ala Val Glu Glu Cys Asp Pro
 225                 230                 235                 240
 Tyr Ser Gly Leu Leu Asn Asp Thr Glu Glu Asn Asn Ser Asp Asn His
                 245                 250                 255    
 Asn His Glu Asp Asp Val Leu Gly Phe Pro Ser Asn Gln Asp Leu Tyr
             260                 265                 270        
 Trp Ser Glu Asp Asp Gln Glu Leu Ile Ile Pro Cys Leu Ala Leu Val
         275                 280                 285            
 Arg Ala Ser Lys Ala Cys Leu Lys Lys Ile Arg Met Leu Val Ala Glu
     290                 295                 300                
 Asn Gly Lys Lys Asp Gln Val Ala Thr Ala Gly Met Thr Leu Trp Asp
 305                 310                 315                 320
 Ile Ser Asp Glu Ile Ser Pro Ser Val Asp Asp Leu Gly Ser Xaa Ala
                 325                 330                 335    
 Tyr Ile Pro Pro Met Cys His Leu Thr Val Arg Ile Asn Phe Trp Arg
             340                 345                 350        
 Asn Leu Tyr Ser Val Leu Lys Lys Gly Thr Leu Lys Ile Thr Lys Ala
         355                 360                 365            
 Ser His Val Thr Pro Gln Pro Glu Asp Ser Trp Ile Pro Leu Pro Tyr
     370                 375                 380                
 Leu Met Pro Met Asp His Ala Met Asn Gly Ile Arg Glu Leu His Ser
 385                 390                 395                 400
 Arg Ser Glu Leu Glu Ile Met Asp Leu Phe Gln Ala Ser Ile Trp Tyr
                 405                 410                 415    
 Ser Leu Pro Pro Leu His Arg Pro Trp Ser Arg Leu
             420                 425            



      <210> 1529
      <211> 124
      <212> PRT
      <213> Homo sapiens


      <400> 1529
 Arg Phe Arg Lys Ala Gln Cys Thr Ile Val Glu Arg Leu Thr Asn Ser
   1               5                  10                  15    
 Met Met Met His Gly Arg Asn Asn Gly Lys Lys Leu Met Thr Val Arg
              20                  25                  30        
 Ile Val Lys His Ala Phe Glu Ile Ile His Leu Leu Thr Gly Glu Asn
          35                  40                  45            
 Pro Leu Gln Val Leu Val Asn Ala Ile Ile Asn Asp Val Ser Pro Leu
      50                  55                  60                
 Arg Arg Val Asn His Ala Ile Trp Leu Leu Cys Thr Gly Ala Arg Glu
  65                  70                  75                  80
 Ala Ala Phe Arg Asn Ile Lys Thr Ile Ala Glu Cys Leu Ala Asp Glu
                  85                  90                  95    
 Leu Ile Asn Ala Ala Lys Gly Ser Ser Asn Ser Tyr Ala Ile Lys Asn
             100                 105                 110        
 Lys Asp Glu Leu Glu Arg Val Ala Lys Ser Asn Arg
         115                 120                



      <210> 1530
      <211> 130
      <212> PRT
      <213> Homo sapiens


      <400> 1530
 Phe Arg Ala Ala Ala Thr Val Gly Arg His Thr Leu Pro Glu His Trp
   1               5                  10                  15    
 Ser Tyr Gly Val Cys Arg Asp Gly Arg Val Phe Phe Ile Asn Asp Gln
              20                  25                  30        
 Leu Arg Cys Thr Thr Trp Leu His Pro Arg Thr Gly Glu Pro Val Asn
          35                  40                  45            
 Ser Gly His Met Ile Arg Ser Tyr Leu Pro Arg Gly Trp Glu Glu Gly
      50                  55                  60                
 Phe Thr Glu Glu Gly Ala Ser Tyr Phe Ile Asp His Asn Gln Gln Thr
  65                  70                  75                  80
 Thr Ala Phe Arg His Pro Val Thr Gly Gln Phe Ser Pro Glu Asn Ser
                  85                  90                  95    
 Glu Phe Ile Leu Gln Glu Glu Pro Asn Pro His Met Ser Lys Gln Asp
             100                 105                 110        
 Arg Asn Gln Arg Pro Ser Ser Met Val Ser Glu Thr Ser Thr Ala Gly
         115                 120                 125            
 Thr Ala
     130



      <210> 1531
      <211> 142
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(142)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1531
 Asn Ser Pro Cys Ser Gly Ser Ser Ile Ala Thr Ala Ser Pro Glu Arg
   1               5                  10                  15    
 Arg Lys Gly Ile Asn Pro Ala Pro Pro Ser Thr Pro Ala Ala Pro Cys
              20                  25                  30        
 Arg Ser Xaa Ala Cys Thr Ala Ala Ala Ala Ala Ala Val Arg Asp Asp
          35                  40                  45            
 Arg Leu Asn Val Thr Glu Glu Leu Thr Ser Asn Asp Lys Thr Arg Ile
      50                  55                  60                
 Leu Asn Val Gln Ser Arg Leu Thr Asp Ala Lys Arg Ile Asn Trp Arg
  65                  70                  75                  80
 Thr Val Leu Ser Gly Gly Ser Leu Tyr Ile Glu Ile Pro Gly Gly Ala
                  85                  90                  95    
 Leu Pro Glu Gly Ser Lys Asp Ser Phe Ala Val Leu Leu Glu Phe Ala
             100                 105                 110        
 Glu Glu Gln Leu Arg Ala Asp His Val Phe Ile Cys Phe His Lys Asn
         115                 120                 125            
 Arg Glu Asp Arg Ala Ala Leu Leu Arg Thr Phe Ser Phe Leu
     130                 135                 140        



      <210> 1532
      <211> 231
      <212> PRT
      <213> Homo sapiens


      <400> 1532
 Phe Arg Gly Leu Gly Pro Asn Leu Val Gly Val Ala Pro Ser Arg Ala
   1               5                  10                  15    
 Val Tyr Phe Ala Cys Tyr Ser Lys Ala Lys Glu Gln Phe Asn Gly Ile
              20                  25                  30        
 Phe Val Pro Asn Ser Asn Ile Val His Ile Phe Ser Ala Gly Ser Ala
          35                  40                  45            
 Ala Phe Ile Thr Asn Ser Leu Met Asn Pro Ile Trp Met Val Lys Thr
      50                  55                  60                
 Arg Met Gln Leu Glu Gln Lys Val Arg Gly Ser Lys Gln Met Asn Thr
  65                  70                  75                  80
 Leu Gln Cys Ala Arg Tyr Val Tyr Gln Thr Glu Gly Ile Arg Gly Phe
                  85                  90                  95    
 Tyr Arg Gly Leu Thr Ala Ser Tyr Ala Gly Ile Ser Glu Thr Ile Ile
             100                 105                 110        
 Cys Phe Ala Ile Tyr Glu Ser Leu Lys Lys Tyr Leu Lys Glu Ala Pro
         115                 120                 125            
 Leu Ala Ser Ser Ala Asn Gly Thr Glu Lys Asn Ser Thr Ser Phe Phe
     130                 135                 140                
 Gly Leu Met Ala Ala Ala Ala Leu Ser Lys Gly Cys Ala Ser Cys Ile
 145                 150                 155                 160
 Ala Tyr Pro His Glu Val Ile Arg Thr Arg Leu Arg Glu Glu Gly Thr
                 165                 170                 175    
 Lys Tyr Lys Ser Phe Val Gln Thr Ala Arg Leu Val Phe Arg Glu Glu
             180                 185                 190        
 Gly Tyr Leu Ala Phe Tyr Arg Gly Leu Phe Ala Gln Leu Ile Arg Gln
         195                 200                 205            
 Ile Pro Asn Thr Ala Ile Val Leu Ser Thr Tyr Glu Leu Ile Val Tyr
     210                 215                 220                
 Leu Leu Glu Asp Arg Thr Gln
 225                 230    



      <210> 1533
      <211> 282
      <212> PRT
      <213> Homo sapiens


      <400> 1533
 Val Trp Arg Asn Ser Ser Asp Leu Gly Val Ile Leu Ser Glu Phe Pro
   1               5                  10                  15    
 Leu Ala Pro Glu Leu Ala Lys Ala Leu Leu Ala Ser Cys Glu Phe Asp
              20                  25                  30        
 Cys Val Asp Glu Met Leu Thr Leu Ala Ala Met Leu Thr Ala Ala Pro
          35                  40                  45            
 Gly Phe Thr Arg Pro Pro Leu Ser Ala Glu Glu Ala Ala Leu Arg Arg
      50                  55                  60                
 Ala Leu Glu His Thr Asp Gly Asp His Ser Ser Leu Ile Gln Val Tyr
  65                  70                  75                  80
 Glu Ala Phe Ile Gln Ser Gly Ala Asp Glu Ala Trp Cys Gln Ala Arg
                  85                  90                  95    
 Gly Leu Asn Trp Ala Ala Leu Cys Gln Ala His Lys Leu Arg Gly Glu
             100                 105                 110        
 Leu Leu Glu Leu Met Gln Arg Ile Glu Leu Pro Leu Ser Leu Pro Ala
         115                 120                 125            
 Phe Gly Ser Glu Gln Asn Arg Arg Asp Leu Gln Lys Ala Leu Val Ser
     130                 135                 140                
 Gly Tyr Phe Leu Lys Val Ala Arg Asp Thr Asp Gly Thr Gly Asn Tyr
 145                 150                 155                 160
 Leu Leu Leu Thr His Lys His Val Ala Gln Leu Ser Ser Ser Ala Ala
                 165                 170                 175    
 Thr Glu Ala Ala Glu Leu Leu Ala Arg Pro Pro Pro Trp Val Ala Phe
             180                 185                 190        
 Thr Thr Ile Phe Thr Ile Ser Lys Asp Asn Cys Leu Ser Ile Val Ser
         195                 200                 205            
 Glu Ile Gln Pro Gln Met Leu Val Glu Leu Ala Pro Pro Tyr Phe Leu
     210                 215                 220                
 Ser Asn Leu Pro Pro Ser Glu Ser Arg Asp Leu Leu Asn Gln Leu Arg
 225                 230                 235                 240
 Glu Gly Met Ala Asp Ser Thr Ala Gly Ser Lys Ser Ser Leu Ser Pro
                 245                 250                 255    
 Arg Ser Ser Glu Ile Pro Cys Val Pro Ala Val Thr Leu Pro Ala Leu
             260                 265                 270        
 Trp Asn Gly Ala Gly Phe Ile Ser Ser His
         275                 280        



      <210> 1534
      <211> 1277
      <212> PRT
      <213> Homo sapiens


      <400> 1534
 Asp Ala Pro Gly Arg Pro Pro Val Arg Leu Pro Thr Met Glu Leu Glu
   1               5                  10                  15    
 Asp Gly Val Val Tyr Gln Glu Glu Pro Gly Gly Ser Gly Ala Val Met
              20                  25                  30        
 Ser Glu Arg Val Ser Gly Leu Ala Gly Ser Ile Tyr Arg Glu Phe Glu
          35                  40                  45            
 Arg Leu Ile Val Arg Tyr Asp Glu Glu Val Val Lys Glu Leu Ile Pro
      50                  55                  60                
 Leu Val Val Ala Val Leu Glu Asn Leu Asp Ser Val Phe Ala Gln Asp
  65                  70                  75                  80
 Gln Glu His Gln Val Glu Leu Glu Leu Leu Arg Asp Asp Asn Glu Gln
                  85                  90                  95    
 Leu Ile Thr Gln Tyr Glu Arg Glu Lys Ala Leu Arg Lys His Ala Glu
             100                 105                 110        
 Glu Lys Phe Ile Glu Phe Glu Asp Ser Gln Glu Gln Glu Lys Lys Asp
         115                 120                 125            
 Leu Gln Thr Arg Val Glu Ser Leu Glu Ser Gln Thr Arg Gln Leu Glu
     130                 135                 140                
 Leu Lys Ala Lys Asn Tyr Ala Asp Gln Ile Ser Ile Leu Glu Glu Arg
 145                 150                 155                 160
 Glu Ala Glu Leu Lys Lys Glu Tyr Asn Ala Leu His Gln Arg His Thr
                 165                 170                 175    
 Glu Met Ile His Asn Tyr Met Glu His Leu Glu Arg Thr Lys Leu His
             180                 185                 190        
 Gln Leu Ser Gly Ser Asp Gln Leu Glu Ser Thr Ala His Ser Arg Ile
         195                 200                 205            
 Arg Lys Glu Arg Pro Ile Ser Leu Gly Ile Phe Pro Leu Pro Ala Gly
     210                 215                 220                
 Asp Gly Leu Leu Thr Pro Asp Ala Gln Lys Gly Gly Glu Thr Pro Gly
 225                 230                 235                 240
 Ser Glu Gln Trp Lys Phe Gln Glu Leu Ser Gln Pro Arg Ser His Thr
                 245                 250                 255    
 Ser Leu Lys Asp Glu Leu Ser Asp Val Ser Gln Gly Gly Ser Lys Ala
             260                 265                 270        
 Thr Thr Pro Ala Ser Thr Ala Asn Ser Asp Val Ala Thr Ile Pro Thr
         275                 280                 285            
 Asp Thr Pro Leu Lys Glu Glu Asn Glu Gly Phe Val Lys Val Thr Asp
     290                 295                 300                
 Ala Pro Asn Lys Ser Glu Ile Ser Lys His Ile Glu Val Gln Val Ala
 305                 310                 315                 320
 Gln Glu Thr Arg Asn Val Ser Thr Gly Ser Ala Glu Asn Glu Glu Lys
                 325                 330                 335    
 Ser Glu Val Gln Ala Ile Ile Glu Ser Thr Pro Glu Leu Asp Met Asp
             340                 345                 350        
 Lys Asp Leu Ser Gly Tyr Lys Gly Ser Ser Thr Pro Thr Lys Gly Ile
         355                 360                 365            
 Glu Asn Lys Ala Phe Asp Arg Asn Thr Glu Ser Leu Phe Glu Glu Leu
     370                 375                 380                
 Ser Ser Ala Gly Ser Gly Leu Ile Gly Asp Val Asp Glu Gly Ala Asp
 385                 390                 395                 400
 Leu Leu Gly Met Gly Arg Glu Val Glu Asn Leu Ile Leu Glu Asn Thr
                 405                 410                 415    
 Gln Leu Leu Glu Thr Lys Asn Ala Leu Asn Ile Val Lys Asn Asp Leu
             420                 425                 430        
 Ile Ala Lys Val Asp Glu Leu Thr Cys Glu Lys Asp Val Leu Gln Gly
         435                 440                 445            
 Glu Leu Glu Ala Val Lys Gln Ala Lys Leu Lys Leu Glu Glu Lys Asn
     450                 455                 460                
 Arg Glu Leu Glu Glu Glu Leu Arg Lys Ala Arg Ala Glu Ala Glu Asp
 465                 470                 475                 480
 Ala Arg Gln Lys Ala Lys Asp Asp Asp Asp Ser Asp Ile Pro Thr Ala
                 485                 490                 495    
 Gln Arg Lys Arg Phe Thr Arg Val Glu Met Ala Arg Val Leu Met Glu
             500                 505                 510        
 Arg Asn Gln Tyr Lys Glu Arg Leu Met Glu Leu Gln Glu Ala Val Arg
         515                 520                 525            
 Trp Thr Glu Met Ile Arg Ala Ser Arg Glu Asn Pro Ala Met Gln Glu
     530                 535                 540                
 Lys Lys Arg Ser Ser Ile Trp Gln Phe Phe Ser Arg Leu Phe Ser Ser
 545                 550                 555                 560
 Ser Ser Asn Thr Thr Lys Lys Pro Glu Pro Pro Val Asn Leu Lys Tyr
                 565                 570                 575    
 Asn Ala Pro Thr Ser His Val Thr Pro Ser Val Lys Lys Arg Ser Ser
             580                 585                 590        
 Thr Leu Ser Gln Leu Pro Gly Asp Lys Ser Lys Ala Phe Asp Phe Leu
         595                 600                 605            
 Ser Glu Glu Thr Glu Ala Ser Leu Ala Ser Arg Arg Glu Gln Lys Arg
     610                 615                 620                
 Glu Gln Tyr Arg Gln Val Lys Ala His Val Gln Lys Glu Asp Gly Arg
 625                 630                 635                 640
 Val Gln Ala Phe Gly Trp Ser Leu Pro Gln Lys Tyr Lys Gln Val Thr
                 645                 650                 655    
 Asn Gly Gln Gly Glu Asn Lys Met Lys Asn Leu Pro Val Pro Val Tyr
             660                 665                 670        
 Leu Arg Pro Leu Asp Lys Lys Asp Thr Ser Met Lys Leu Trp Cys Ala
         675                 680                 685            
 Val Gly Val Asn Leu Ser Gly Gly Lys Thr Arg Asp Gly Gly Ser Val
     690                 695                 700                
 Val Gly Ala Ser Val Phe Tyr Lys Asp Val Ala Gly Leu Asp Thr Glu
 705                 710                 715                 720
 Gly Ser Lys Gln Arg Ser Ala Ser Gln Ser Ser Leu Asp Lys Leu Asp
                 725                 730                 735    
 Gln Glu Leu Lys Glu Gln Gln Lys Glu Leu Lys Asn Gln Glu Glu Leu
             740                 745                 750        
 Ser Ser Leu Val Trp Ile Cys Thr Ser Thr His Ser Ala Thr Lys Val
         755                 760                 765            
 Leu Ile Ile Asp Ala Val Gln Pro Gly Asn Ile Leu Asp Ser Phe Thr
     770                 775                 780                
 Val Cys Asn Ser His Val Leu Cys Ile Ala Ser Val Pro Gly Ala Arg
 785                 790                 795                 800
 Glu Thr Asp Tyr Pro Ala Gly Glu Asp Leu Ser Glu Ser Gly Gln Val
                 805                 810                 815    
 Asp Lys Ala Ser Leu Cys Gly Ser Met Thr Ser Asn Ser Ser Ala Glu
             820                 825                 830        
 Thr Asp Ser Leu Leu Gly Gly Ile Thr Val Val Gly Cys Ser Ala Glu
         835                 840                 845            
 Gly Val Thr Gly Ala Ala Thr Ser Pro Ser Thr Asn Gly Ala Ser Pro
     850                 855                 860                
 Val Met Asp Lys Pro Pro Glu Met Glu Ala Glu Asn Ser Glu Val Asp
 865                 870                 875                 880
 Glu Asn Val Pro Thr Ala Glu Glu Ala Thr Glu Ala Thr Glu Gly Asn
                 885                 890                 895    
 Ala Gly Ser Ala Glu Asp Thr Val Asp Ile Ser Gln Thr Gly Val Tyr
             900                 905                 910        
 Thr Glu His Val Phe Thr Asp Pro Leu Gly Val Gln Ile Pro Glu Asp
         915                 920                 925            
 Leu Ser Pro Val Tyr Gln Ser Ser Asn Asp Ser Asp Ala Tyr Lys Asp
     930                 935                 940                
 Gln Ile Ser Val Leu Pro Asn Glu Gln Asp Leu Val Arg Glu Glu Ala
 945                 950                 955                 960
 Gln Lys Met Ser Ser Leu Leu Pro Thr Met Trp Leu Gly Ala Gln Asn
                 965                 970                 975    
 Gly Cys Leu Tyr Val His Ser Ser Val Ala Gln Trp Arg Lys Cys Leu
             980                 985                 990        
 His Ser Ile Lys Leu Lys Asp Ser Ile Leu Ser Ile Val His Val Lys
         995                1000                1005            
 Gly Ile Val Leu Val Ala Leu Ala Asp Gly Thr Leu Ala Ile Phe His
    1010                1015                1020                
 Arg Gly Val Asp Gly Gln Trp Asp Leu Ser Asn Tyr His Leu Leu Asp
1025                1030                1035                1040
 Leu Gly Arg Pro His His Ser Ile Arg Cys Met Thr Val Val His Asp
                1045                1050                1055    
 Lys Val Trp Cys Gly Tyr Arg Asn Lys Ile Tyr Val Val Gln Pro Lys
            1060                1065                1070        
 Ala Met Lys Ile Glu Lys Ser Phe Asp Ala His Pro Arg Lys Glu Ser
        1075                1080                1085            
 Gln Val Arg Gln Leu Ala Trp Val Gly Asp Gly Val Trp Val Ser Ile
    1090                1095                1100                
 Arg Leu Asp Ser Thr Leu Arg Leu Tyr His Ala His Thr Tyr Gln His
1105                1110                1115                1120
 Leu Gln Asp Val Asp Ile Glu Pro Tyr Val Ser Lys Met Leu Gly Thr
                1125                1130                1135    
 Gly Lys Leu Gly Phe Ser Phe Val Arg Ile Thr Ala Leu Met Val Ser
            1140                1145                1150        
 Cys Asn Arg Leu Trp Val Gly Thr Gly Asn Gly Val Ile Ile Ser Ile
        1155                1160                1165            
 Pro Leu Thr Glu Thr Val Ile Leu His Gln Gly Arg Leu Leu Gly Leu
    1170                1175                1180                
 Arg Ala Asn Lys Thr Ser Gly Val Pro Gly Asn Arg Pro Gly Ser Val
1185                1190                1195                1200
 Ile Arg Val Tyr Gly Asp Glu Asn Ser Asp Lys Val Thr Pro Gly Thr
                1205                1210                1215    
 Phe Ile Pro Tyr Cys Ser Met Ala His Ala Gln Leu Cys Phe His Gly
            1220                1225                1230        
 His Arg Asp Ala Val Lys Phe Phe Val Ala Val Pro Gly Gln Val Ile
        1235                1240                1245            
 Ser Pro Gln Ser Ser Ser Ser Gly Thr Asp Leu Thr Gly Asp Lys Gly
    1250                1255                1260                
 Arg Gly His Leu His Arg Ser Leu Val Val Arg Arg Pro
1265                1270                1275        



      <210> 1535
      <211> 628
      <212> PRT
      <213> Homo sapiens


      <400> 1535
 Met Asp Gly Leu Gln Ala Ser Ala Gly Pro Leu Arg Arg Gly Arg Pro
   1               5                  10                  15    
 Lys Arg Arg Arg Lys Pro Gln Pro His Ser Gly Ser Val Leu Ala Leu
              20                  25                  30        
 Pro Leu Arg Ser Arg Lys Ile Arg Lys Gln Leu Arg Ser Val Val Ser
          35                  40                  45            
 Arg Met Ala Ala Leu Arg Thr Gln Thr Leu Pro Ser Glu Asn Ser Glu
      50                  55                  60                
 Glu Ser Arg Val Glu Ser Thr Ala Asp Asp Leu Gly Asp Ala Leu Pro
  65                  70                  75                  80
 Ala Arg Arg Glu Pro Tyr Gly His Leu Gly Pro Ala Glu Leu Leu Glu
                  85                  90                  95    
 Ala Ser Pro Ala Ala Arg Ser Leu Gln Thr Pro Ser Ala Arg Leu Val
             100                 105                 110        
 Pro Ala Ser Ala Pro Pro Ala Arg Leu Val Glu Val Pro Ala Ala Pro
         115                 120                 125            
 Val Arg Val Val Glu Thr Ser Ala Leu Leu Cys Thr Ala Gln His Leu
     130                 135                 140                
 Ala Ala Val Gln Ser Ser Gly Ala Pro Ala Thr Ala Ser Gly Pro Gln
 145                 150                 155                 160
 Val Asp Asn Thr Gly Gly Glu Pro Ala Trp Asp Ser Pro Leu Arg Arg
                 165                 170                 175    
 Val Leu Ala Glu Leu Asn Arg Ile Pro Ser Ser Arg Arg Arg Ala Ala
             180                 185                 190        
 Arg Leu Phe Glu Trp Leu Ile Ala Pro Met Pro Pro Asp His Phe Tyr
         195                 200                 205            
 Arg Arg Leu Trp Glu Arg Glu Ala Val Leu Val Arg Arg Gln Asp His
     210                 215                 220                
 Thr Tyr Tyr Gln Gly Leu Phe Ser Thr Ala Asp Leu Asp Ser Met Leu
 225                 230                 235                 240
 Arg Asn Glu Glu Val Gln Phe Gly Gln His Leu Asp Ala Ala Arg Tyr
                 245                 250                 255    
 Ile Asn Gly Arg Arg Glu Thr Leu Asn Pro Pro Gly Arg Ala Leu Pro
             260                 265                 270        
 Ala Asp Arg Val Val Pro Val Pro Gly Arg Leu Leu Ala Cys Val Ser
         275                 280                 285            
 Ser Ala Phe Ser Thr Thr Val Trp Gln Phe Leu Ala Val Leu Gln Glu
     290                 295                 300                
 Gln Phe Gly Ser Met Ala Gly Ser Asn Val Tyr Leu Thr Pro Pro Asn
 305                 310                 315                 320
 Ser Gln Gly Phe Ala Pro His Tyr Asp Asp Ile Glu Ala Phe Val Leu
                 325                 330                 335    
 Gln Leu Glu Gly Arg Lys Leu Trp Arg Val Tyr Arg Pro Arg Val Pro
             340                 345                 350        
 Thr Glu Glu Leu Ala Leu Thr Ser Ser Pro Asn Phe Ser Gln Asp Asp
         355                 360                 365            
 Leu Gly Glu Pro Val Leu Gln Thr Val Leu Glu Pro Gly Asp Leu Leu
     370                 375                 380                
 Tyr Phe Pro Arg Gly Phe Ile His Gln Ala Glu Cys Gln Asp Gly Val
 385                 390                 395                 400
 His Ser Leu His Leu Thr Leu Ser Thr Tyr Gln Arg Asn Thr Trp Gly
                 405                 410                 415    
 Asp Phe Leu Glu Ala Ile Leu Pro Leu Ala Val Gln Ala Ala Met Glu
             420                 425                 430        
 Glu Asn Val Glu Phe Arg Arg Gly Leu Pro Arg Asp Phe Met Asp Tyr
         435                 440                 445            
 Met Gly Ala Gln His Ser Asp Ser Lys Asp Pro Arg Arg Thr Ala Phe
     450                 455                 460                
 Met Glu Lys Val Arg Val Leu Val Ala Arg Leu Gly His Phe Ala Pro
 465                 470                 475                 480
 Val Asp Ala Val Ala Asp Gln Arg Ala Lys Asp Phe Ile His Asp Ser
                 485                 490                 495    
 Leu Pro Pro Val Leu Thr Asp Arg Glu Arg Ala Leu Ser Val Tyr Gly
             500                 505                 510        
 Leu Pro Ile Arg Trp Glu Ala Gly Glu Pro Val Asn Val Gly Ala Gln
         515                 520                 525            
 Leu Thr Thr Glu Thr Glu Val His Met Leu Gln Asp Gly Ile Ala Arg
     530                 535                 540                
 Leu Val Gly Glu Gly Gly His Leu Phe Leu Tyr Tyr Thr Val Glu Asn
 545                 550                 555                 560
 Ser Arg Val Tyr His Leu Glu Glu Pro Lys Cys Leu Glu Ile Tyr Pro
                 565                 570                 575    
 Gln Gln Ala Asp Ala Met Glu Leu Leu Leu Gly Ser Tyr Pro Glu Phe
             580                 585                 590        
 Val Arg Val Gly Asp Leu Pro Cys Asp Ser Val Glu Asp Gln Leu Ser
         595                 600                 605            
 Leu Ala Thr Thr Leu Tyr Asp Lys Gly Leu Leu Leu Thr Lys Met Pro
     610                 615                 620                
 Leu Ala Leu Asn
 625            



      <210> 1536
      <211> 263
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(263)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1536
 Leu Gln Glu Asn Thr Gln Ile Glu Pro Ser Glu Pro Lys Asn Gln Glu
   1               5                  10                  15    
 Glu Lys Lys Leu Ser Gln Val Leu Asn Glu Leu Gln Val Ser His Ala
              20                  25                  30        
 Glu Thr Thr Leu Glu Leu Glu Lys Thr Arg Asp Met Leu Ile Leu Gln
          35                  40                  45            
 Arg Lys Ile Asn Val Cys Tyr Gln Val Gln Gly Lys Met Val Gln Glu
      50                  55                  60                
 Gly Asp Gly Xaa Gln Glu Arg Gly Asn His Ser Gln Asp Trp Glu Xaa
  65                  70                  75                  80
 Ser Lys Thr Xaa Val Ser Arg Ala Asp Tyr Gln Glu Glu Leu Glu Ala
                  85                  90                  95    
 Met Met Thr Lys Ala Asp Asn Asp Asn Arg Asp His Lys Glu Lys Leu
             100                 105                 110        
 Glu Arg Leu Thr Arg Leu Leu Asp Leu Lys Asn Asn Arg Ile Lys Gln
         115                 120                 125            
 Leu Glu Gly Ile Leu Arg Ser His Asp Leu Pro Thr Ser Leu Lys Asp
     130                 135                 140                
 Val Ala Tyr Gly Thr Arg Pro Leu Ser Leu Cys Leu Glu Thr Leu Pro
 145                 150                 155                 160
 Ala His Gly Asp Glu Asp Lys Val Asp Ile Ser Leu Leu His Gln Gly
                 165                 170                 175    
 Glu Asn Leu Phe Glu Leu His Ile His Gln Ala Phe Leu Thr Ser Ala
             180                 185                 190        
 Ala Leu Ala Gln Ala Gly Asp Thr Gln Pro Thr Thr Phe Cys Thr Tyr
         195                 200                 205            
 Ser Phe Tyr Asp Phe Glu Thr His Cys Thr Pro Leu Ser Val Gly Pro
     210                 215                 220                
 Gln Pro Leu Tyr Asp Phe Thr Ser Gln Tyr Val Met Glu Thr Asp Ser
 225                 230                 235                 240
 Leu Phe Leu His Tyr Leu Gln Glu Ala Ser Ala Arg Leu Asp Ile His
                 245                 250                 255    
 Gln Ala Met Ala Ser Glu His
             260            



      <210> 1537
      <211> 155
      <212> PRT
      <213> Homo sapiens


      <400> 1537
 Met Ser Glu Asp Ser Asp Ser Gly Asp Asp Phe Phe Ile Gly Lys Val
   1               5                  10                  15    
 Arg Arg Thr Arg Lys Lys Glu Ser Ser Cys His Ser Ser Val Lys Glu
              20                  25                  30        
 Gln Lys Pro Leu Glu Lys Val Phe Leu Lys Glu Asp Thr Gly Glu Thr
          35                  40                  45            
 His Gly Asp Thr Arg Asn Asp Lys Ile Lys Pro Ser Thr Glu Thr Arg
      50                  55                  60                
 Lys Leu Glu Ser Val Phe Phe His Ser Leu Ser Gly Ser Lys Ser Ser
  65                  70                  75                  80
 Arg Arg Asn Phe Lys Glu Gln Ala Pro Lys Thr Arg Ser Leu Asp Phe
                  85                  90                  95    
 Pro Gln Asn Glu Pro Gln Ile Lys Asn Gln Phe Asn Lys Lys Leu Ser
             100                 105                 110        
 Gly Arg Leu Glu Asn Thr Lys Gln Gln Leu Gln Leu Pro Leu His Pro
         115                 120                 125            
 Ser Trp Glu Ala Ser Arg Arg Arg Lys Glu Gln Gln Ser Asn Ile Ala
     130                 135                 140                
 Val Phe Gln Gly Lys Lys Ile Thr Phe Asp Asp
 145                 150                 155



      <210> 1538
      <211> 246
      <212> PRT
      <213> Homo sapiens


      <400> 1538
 Arg His Asp Phe Ile Trp Ile Gln Ala Ser Pro Ile Ser Ala Ser Phe
   1               5                  10                  15    
 Leu Gly Arg Ala Glu Asp Ser Leu Thr Ala His Gly Arg Leu Ser Arg
              20                  25                  30        
 Asp Arg Arg Met Arg Gly Leu Arg Trp Arg Tyr Thr Arg Leu Pro Ser
          35                  40                  45            
 Gln Val Glu Asp Thr Leu Ser Gly Glu Glu Gly Asn Glu Glu Glu Glu
      50                  55                  60                
 Glu Glu Glu Ala Ala Pro Asp Pro Ala Ala Ala Pro Glu Asp Pro Thr
  65                  70                  75                  80
 Val Pro Gln Leu Thr Glu Ala Ser Gln Val Leu Ser Ala Ser Glu Ile
                  85                  90                  95    
 Arg Gln Leu Ser Phe His Phe Pro Pro Arg Val Thr Gly His Pro Trp
             100                 105                 110        
 Ser Leu Val Phe Cys Thr Ser Arg Asp Gly Phe Ser Leu Gln Ser Leu
         115                 120                 125            
 Tyr Arg Arg Met Glu Gly Cys Ser Gly Pro Val Leu Leu Val Leu Arg
     130                 135                 140                
 Asp Gln Asp Gly Gln Ile Phe Gly Ala Phe Ser Ser Ser Ala Ile Arg
 145                 150                 155                 160
 Leu Ser Lys Gly Phe Tyr Gly Thr Gly Glu Thr Phe Leu Phe Ser Phe
                 165                 170                 175    
 Ser Pro Gln Leu Lys Val Phe Lys Trp Thr Gly Ser Asn Ser Phe Phe
             180                 185                 190        
 Val Lys Gly Asp Leu Asp Ser Leu Met Met Gly Ser Gly Ser Gly Arg
         195                 200                 205            
 Phe Gly Leu Trp Leu Asp Gly Asp Leu Phe Arg Gly Gly Ser Ser Pro
     210                 215                 220                
 Cys Pro Thr Phe Asn Asn Glu Val Leu Ala Arg Gln Glu Ala Ser Ser
 225                 230                 235                 240
 Ala Ile Gln Glu Leu Glu
                 245    



      <210> 1539
      <211> 494
      <212> PRT
      <213> Homo sapiens


      <400> 1539
 Arg Thr Lys Met Thr Phe Lys Asp Leu Gly Met Asp Asp Leu Gly Ile
   1               5                  10                  15    
 Tyr Ser Cys Asp Val Thr Asp Thr Asp Gly Ile Ala Ser Ser Tyr Leu
              20                  25                  30        
 Ile Asp Glu Glu Glu Leu Lys Arg Leu Leu Ala Leu Ser His Glu His
          35                  40                  45            
 Lys Phe Pro Thr Val Pro Val Lys Ser Glu Leu Ala Val Glu Ile Leu
      50                  55                  60                
 Glu Lys Gly Gln Val Arg Phe Trp Met Gln Ala Glu Lys Leu Ser Gly
  65                  70                  75                  80
 Asn Ala Lys Val Asn Tyr Ile Phe Asn Glu Lys Glu Ile Phe Glu Gly
                  85                  90                  95    
 Pro Lys Tyr Lys Met His Ile Asp Arg Asn Thr Gly Ile Ile Glu Met
             100                 105                 110        
 Phe Met Glu Lys Leu Gln Asp Glu Asp Glu Gly Thr Tyr Thr Phe Gln
         115                 120                 125            
 Leu Gln Asp Gly Lys Ala Thr Asn His Ser Thr Val Val Leu Val Gly
     130                 135                 140                
 Asp Val Phe Lys Lys Leu Gln Lys Glu Ala Glu Phe Gln Arg Gln Glu
 145                 150                 155                 160
 Trp Ile Arg Lys Gln Gly Pro His Phe Val Glu Tyr Leu Ser Trp Glu
                 165                 170                 175    
 Val Thr Gly Glu Cys Asn Val Leu Leu Lys Cys Lys Val Ala Asn Ile
             180                 185                 190        
 Lys Lys Glu Thr His Ile Val Trp Tyr Lys Asp Glu Arg Glu Ile Ser
         195                 200                 205            
 Val Asp Glu Lys His Asp Phe Lys Asp Gly Ile Cys Thr Leu Leu Ile
     210                 215                 220                
 Thr Glu Phe Ser Lys Lys Asp Ala Gly Ile Tyr Glu Val Ile Leu Lys
 225                 230                 235                 240
 Asp Asp Arg Gly Lys Asp Lys Ser Arg Leu Lys Leu Val Asp Glu Ala
                 245                 250                 255    
 Phe Lys Glu Leu Met Met Glu Val Cys Lys Lys Ile Ala Leu Ser Ala
             260                 265                 270        
 Thr Asp Leu Lys Ile Gln Ser Thr Ala Glu Gly Ile Gln Leu Tyr Ser
         275                 280                 285            
 Phe Val Thr Tyr Tyr Val Glu Asp Leu Lys Val Asn Trp Ser His Asn
     290                 295                 300                
 Gly Ser Ala Ile Arg Tyr Ser Asp Arg Val Lys Thr Gly Val Thr Gly
 305                 310                 315                 320
 Glu Gln Ile Trp Leu Gln Ile Asn Glu Pro Thr Pro Asn Asp Lys Gly
                 325                 330                 335    
 Lys Tyr Val Met Glu Leu Phe Asp Gly Lys Thr Gly His Gln Lys Thr
             340                 345                 350        
 Val Asp Leu Ser Gly Gln Ala Tyr Asp Glu Ala Tyr Ala Glu Phe Gln
         355                 360                 365            
 Arg Leu Lys Gln Ala Ala Ile Ala Glu Lys Asn Arg Ala Arg Val Leu
     370                 375                 380                
 Gly Gly Leu Pro Asp Val Val Thr Ile Gln Glu Gly Lys Ala Leu Asn
 385                 390                 395                 400
 Leu Thr Cys Asn Val Trp Gly Asp Pro Pro Pro Glu Val Ser Trp Leu
                 405                 410                 415    
 Lys Asn Glu Lys Ala Leu Ala Ser Asp Asp His Cys Asn Leu Lys Phe
             420                 425                 430        
 Glu Ala Gly Arg Thr Ala Tyr Phe Thr Ile Asn Gly Val Ser Thr Ala
         435                 440                 445            
 Asp Ser Gly Lys Tyr Gly Leu Val Val Lys Asn Lys Tyr Gly Ser Glu
     450                 455                 460                
 Thr Ser Asp Phe Thr Val Ser Val Phe Ile Pro Glu Glu Glu Ala Arg
 465                 470                 475                 480
 Met Ala Ala Leu Glu Ser Leu Lys Gly Gly Lys Lys Ala Lys
                 485                 490                



      <210> 1540
      <211> 83
      <212> PRT
      <213> Homo sapiens


      <400> 1540
 Met Pro Phe Ser Thr Cys Thr Ala Leu Pro Ser Trp Ala Thr Leu Ser
   1               5                  10                  15    
 Thr Trp Ser Trp Thr Pro Lys Val Ser Leu Ala Gly Glu Glu Arg Gly
              20                  25                  30        
 Glu Thr Cys Gln Pro Asp Pro Phe Pro Pro His Pro Ser Cys Ser Val
          35                  40                  45            
 Gly Arg Thr Pro Pro His Ser Ser Leu Gly Ser Pro Pro Thr Thr Leu
      50                  55                  60                
 Phe Leu Ser Pro Leu Leu Arg Val Glu Ser Arg Gly Ala Lys Cys Val
  65                  70                  75                  80
 Val Cys Cys
            



      <210> 1541
      <211> 392
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(392)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1541
 Trp Pro Ala Phe Pro Arg Gln Pro Ala Ala Ala Ala Met Asp Ala Leu
   1               5                  10                  15    
 Leu Gly Thr Gly Pro Arg Arg Ala Arg Gly Cys Leu Gly Ala Ala Gly
              20                  25                  30        
 Pro Thr Ser Ser Gly Arg Ala Ala Arg Thr Pro Ala Ala Pro Trp Ala
          35                  40                  45            
 Arg Phe Ser Ala Trp Leu Glu Cys Val Cys Val Val Thr Phe Asp Leu
      50                  55                  60                
 Glu Leu Gly Gln Ala Leu Glu Leu Val Tyr Pro Asn Asp Phe Arg Leu
  65                  70                  75                  80
 Thr Asp Lys Glu Lys Ser Ser Ile Cys Tyr Leu Ser Phe Pro Asp Ser
                  85                  90                  95    
 His Ser Gly Cys Leu Gly Asp Thr Gln Phe Ser Phe Arg Met Arg Gln
             100                 105                 110        
 Cys Gly Gly Gln Arg Ser Pro Trp His Ala Asp Asp Arg His Tyr Asn
         115                 120                 125            
 Ser Arg Ala Pro Val Ala Leu Gln Arg Glu Pro Ala His Tyr Phe Gly
     130                 135                 140                
 Tyr Val Tyr Phe Arg Gln Val Lys Asp Ser Ser Val Lys Arg Gly Tyr
 145                 150                 155                 160
 Phe Gln Lys Ser Leu Val Leu Val Ser Arg Leu Pro Phe Val Arg Leu
                 165                 170                 175    
 Phe Gln Ala Leu Leu Ser Leu Ile Ala Pro Glu Tyr Phe Asp Lys Leu
             180                 185                 190        
 Ala Pro Cys Leu Glu Ala Val Cys Ser Glu Ile Asp Gln Trp Pro Ala
         195                 200                 205            
 Pro Ala Pro Gly Gln Thr Leu Asn Leu Pro Val Met Gly Val Val Val
     210                 215                 220                
 Gln Val Arg Ile Pro Ser Arg Val Asp Lys Ser Glu Ser Ser Pro Pro
 225                 230                 235                 240
 Lys Gln Phe Asp Gln Glu Asn Leu Leu Pro Ala Pro Val Val Leu Ala
                 245                 250                 255    
 Ser Val His Glu Leu Asp Leu Phe Arg Cys Phe Arg Pro Val Leu Thr
             260                 265                 270        
 His Met Gln Thr Leu Trp Glu Leu Met Leu Leu Gly Glu Pro Leu Leu
         275                 280                 285            
 Val Leu Ala Pro Ser Pro Asp Val Ser Ser Glu Met Val Leu Ala Leu
     290                 295                 300                
 Thr Ser Cys Leu Gln Pro Leu Arg Phe Cys Cys Asp Phe Arg Pro Tyr
 305                 310                 315                 320
 Phe Thr Ile His Asp Ser Glu Phe Lys Glu Phe Thr Thr Arg Thr Gln
                 325                 330                 335    
 Ala Pro Pro Asn Val Val Leu Gly Val Thr Asn Pro Phe Phe Ile Lys
             340                 345                 350        
 Thr Leu Gln His Trp Pro His Ile Leu Arg Val Gly Glu Pro Lys Met
         355                 360                 365            
 Ser Gly Asp Leu Pro Lys Gln Val Lys Leu Lys Lys Pro Phe Lys Val
     370                 375                 380                
 Xaa Arg Pro Trp Asp Thr Lys Pro
 385                 390        



      <210> 1542
      <211> 174
      <212> PRT
      <213> Homo sapiens


      <400> 1542
 Asn Ser Arg Val Asp Asp Phe Val Ala Ala Gly Gly Gly Gly Gly Ser
   1               5                  10                  15    
 Ser Lys Ala Ser Ser Ser Ser Ala Ser Ser Ala Gly Ala Leu Glu Ser
              20                  25                  30        
 Ser Leu Asp Arg Lys Phe Gln Ser Val Thr Asn Thr Met Glu Ser Ile
          35                  40                  45            
 Gln Gly Leu Ser Ser Trp Cys Ile Glu Asn Lys Lys His His Ser Thr
      50                  55                  60                
 Ile Val Tyr His Trp Met Lys Trp Leu Arg Arg Ser Ala Tyr Pro His
  65                  70                  75                  80
 Arg Leu Asn Leu Phe Tyr Leu Ala Asn Asp Val Ile Gln Asn Cys Lys
                  85                  90                  95    
 Arg Lys Asn Ala Ile Ile Phe Arg Glu Ser Phe Ala Asp Val Leu Pro
             100                 105                 110        
 Glu Ala Ala Ala Leu Val Lys Asp Pro Ser Val Ser Lys Ser Val Glu
         115                 120                 125            
 Arg Ile Phe Lys Ile Trp Glu Asp Arg Asn Val Tyr Pro Glu Glu Met
     130                 135                 140                
 Ile Val Ala Leu Arg Glu Ala Leu Ser Thr Thr Phe Lys Thr Gln Lys
 145                 150                 155                 160
 Gln Leu Lys Glu Asn Leu Asn Lys Gln Pro Asn Lys Gln Cys
                 165                 170                



      <210> 1543
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 1543
 Pro Pro Leu Ala Cys Arg Thr Pro Ile Leu Thr Trp Ala Leu Ser Pro
   1               5                  10                  15    
 His Leu Trp Ala Pro Ser Tyr Leu Gly Ser Pro Pro Asp Leu Gly Ala
              20                  25                  30        
 Pro Ser Ser Asp Pro Ser Leu Pro Pro Pro His Ser Gly Pro Leu Ile
          35                  40                  45            
 Leu Thr His His Pro Gln Phe Leu Thr Gln Asp Pro Arg Ser Tyr Pro
      50                  55                  60                
 Gly Leu Ala Leu Thr Ser Leu Tyr Pro Gln Asn Thr Thr Leu Asp Leu
  65                  70                  75                  80
 Leu Asp Arg Gly Leu Gln Val His Val Val Val Asp Ala Cys Ser Ser
                  85                  90                  95    
 Arg Ser Gln Val Asp Arg Leu Val Ala Leu Ala Arg Met Arg Gln Ser
             100                 105                 110        
 Gly Ala Phe Leu Ser Thr Ser Glu Gly Leu Ile Leu Gln Leu Val Gly
         115                 120                 125            
 Asp Ala Val His Pro Gln Phe Lys Glu Ile Gln Lys Leu Ile Lys Glu
     130                 135                 140                
 Pro Ala Pro Asp Ser Gly Leu Leu Gly Leu Phe Gln Gly Gln Asn Ser
 145                 150                 155                 160
 Leu Leu His
            



      <210> 1544
      <211> 238
      <212> PRT
      <213> Homo sapiens


      <400> 1544
 Leu Lys Lys Asn His Glu Glu Glu Met Lys Ala Leu Gln Cys Ala Ala
   1               5                  10                  15    
 Gly Gly Asn Val Asn Val Glu Met Asn Ala Ala Pro Gly Val Asp Leu
              20                  25                  30        
 Thr Val Leu Leu Asn Asn Met Arg Ala Glu Tyr Glu Ala Leu Ala Glu
          35                  40                  45            
 Gln Asn Arg Arg Asp Ala Glu Ala Trp Phe Asn Glu Lys Ser Ala Ser
      50                  55                  60                
 Leu Gln Gln Gln Ile Ser Asp Asp Ala Gly Ala Thr Thr Ser Ala Arg
  65                  70                  75                  80
 Asn Glu Leu Thr Glu Met Lys Arg Thr Leu Gln Thr Leu Glu Ile Glu
                  85                  90                  95    
 Leu Gln Ser Leu Leu Ala Thr Lys His Ser Leu Glu Cys Ser Leu Thr
             100                 105                 110        
 Glu Thr Glu Ser Asn Tyr Cys Ala Gln Leu Ala Gln Ile Gln Ala Gln
         115                 120                 125            
 Ile Gly Ala Leu Glu Glu Gln Leu His Gln Val Arg Thr Glu Thr Glu
     130                 135                 140                
 Gly Gln Lys Leu Glu Tyr Glu Gln Leu Leu Asp Ile Lys Val His Leu
 145                 150                 155                 160
 Glu Lys Glu Ile Glu Thr Tyr Cys Leu Leu Ile Asp Gly Glu Asp Gly
                 165                 170                 175    
 Ser Cys Ser Lys Ser Lys Gly Tyr Gly Gly Pro Gly Asn Gln Thr Lys
             180                 185                 190        
 Asp Ser Ser Lys Thr Thr Ile Val Lys Thr Val Val Glu Glu Ile Asp
         195                 200                 205            
 Pro Arg Gly Lys Val Leu Ser Ser Arg Val His Thr Val Glu Glu Lys
     210                 215                 220                
 Ser Thr Lys Val Asn Asn Lys Asn Glu Gln Arg Val Ser Ser
 225                 230                 235            



      <210> 1545
      <211> 118
      <212> PRT
      <213> Homo sapiens


      <400> 1545
 Gln Gly Leu Asp Pro Ala Ser Gln Thr Lys Val Val Glu Leu Leu Lys
   1               5                  10                  15    
 Asp Gly Ser Gly Arg Arg Gly Asp Arg Arg Ser Ser Arg Asp Met Ala
              20                  25                  30        
 Gly Gly Ala Gly Pro Arg Ser Glu Ser Asp Leu Glu Asp Val Gly Pro
          35                  40                  45            
 Thr Ala Glu Trp Asn Gly Asp Gly Ser Gly Ser Leu Arg Arg Ser Gly
      50                  55                  60                
 Ser Phe Gly Lys Leu Arg Asp Ala Leu Arg Arg Ser Ser Glu Met Leu
  65                  70                  75                  80
 Val Lys Lys Leu Gln Gly Gly Thr Pro Gln Glu Pro Pro Asn Pro Arg
                  85                  90                  95    
 Met Lys Arg Ala Ser Ser Leu Asn Phe Leu Asn Lys Ser Val Glu Glu
             100                 105                 110        
 Pro Thr Gln Pro Gly Gly
         115            



      <210> 1546
      <211> 200
      <212> PRT
      <213> Homo sapiens


      <400> 1546
 Met Ala Pro Ser Arg Asn Gly Met Val Leu Lys Pro His Phe His Lys
   1               5                  10                  15    
 Asp Trp Gln Arg Arg Val Ala Thr Trp Phe Asn Gln Pro Ala Arg Lys
              20                  25                  30        
 Ile Arg Arg Arg Lys Ala Arg Gln Ala Lys Ala Arg Arg Ile Ala Pro
          35                  40                  45            
 Arg Pro Ala Ser Gly Pro Ile Arg Pro Ile Val Arg Cys Pro Thr Val
      50                  55                  60                
 Arg Tyr His Thr Lys Val Arg Ala Gly Arg Gly Phe Ser Leu Glu Glu
  65                  70                  75                  80
 Leu Arg Val Ala Gly Ile His Lys Lys Val Ala Arg Thr Ile Gly Ile
                  85                  90                  95    
 Ser Val Asp Pro Arg Arg Arg Asn Lys Ser Thr Glu Ser Leu Gln Ala
             100                 105                 110        
 Asn Val Gln Arg Leu Lys Glu Tyr Arg Ser Lys Leu Ile Leu Phe Pro
         115                 120                 125            
 Arg Lys Pro Ser Ala Pro Lys Lys Gly Asp Ser Ser Ala Glu Glu Leu
     130                 135                 140                
 Lys Leu Ala Thr Gln Leu Thr Gly Pro Val Met Pro Val Arg Asn Val
 145                 150                 155                 160
 Tyr Lys Lys Glu Lys Ala Arg Val Ile Thr Glu Glu Glu Lys Asn Phe
                 165                 170                 175    
 Lys Ala Phe Ala Ser Leu Val Met Pro Val Gln Arg Pro Asp Leu Arg
             180                 185                 190        
 His Thr Ala Gln Arg Ala Arg Glu
         195                 200



      <210> 1547
      <211> 354
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(354)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1547
 Asp His Tyr Tyr Ala Gln Leu Gly Thr Arg Ala Gly Arg Ala Gly Ile
   1               5                  10                  15    
 Asp Thr Ile Gly Glu Ser Ile Leu Ile Leu Gln Glu Lys Asp Lys Gln
              20                  25                  30        
 Gln Val Leu Glu Leu Ile Thr Lys Pro Leu Glu Asn Cys Tyr Ser His
          35                  40                  45            
 Leu Val Gln Glu Phe Thr Lys Gly Ile Gln Thr Leu Phe Leu Ser Leu
      50                  55                  60                
 Ile Gly Leu Lys Ile Ala Thr Asn Leu Asp Asp Ile Tyr His Phe Met
  65                  70                  75                  80
 Asn Gly Thr Phe Phe Gly Val Gln Gln Lys Val Leu Leu Lys Glu Lys
                  85                  90                  95    
 Ser Leu Trp Glu Ile Thr Val Glu Ser Leu Arg Tyr Leu Thr Glu Lys
             100                 105                 110        
 Gly Leu Leu Gln Lys Asp Thr Ile Tyr Lys Ser Glu Glu Glu Val Gln
         115                 120                 125            
 Tyr Asn Phe His Ile Thr Lys Leu Gly Arg Ala Ser Phe Lys Gly Thr
     130                 135                 140                
 Ile Asp Leu Ala Tyr Cys Asp Ile Leu Tyr Arg Asp Leu Lys Lys Gly
 145                 150                 155                 160
 Leu Glu Gly Leu Val Leu Glu Ser Leu Leu His Leu Ile Tyr Leu Thr
                 165                 170                 175    
 Thr Pro Tyr Asp Leu Val Ser Gln Cys Asn Pro Asp Trp Met Ile Tyr
             180                 185                 190        
 Phe Arg Gln Phe Ser Gln Leu Ser Pro Ala Glu Gln Asn Val Ala Ala
         195                 200                 205            
 Ile Leu Gly Val Ser Glu Ser Phe Ile Gly Lys Lys Ala Ser Gly Gln
     210                 215                 220                
 Ala Ile Gly Lys Lys Val Asp Lys Asn Val Val Asn Arg Leu Tyr Leu
 225                 230                 235                 240
 Ser Phe Val Leu Tyr Thr Leu Leu Lys Glu Thr Asn Ile Trp Thr Val
                 245                 250                 255    
 Ser Glu Lys Phe Asn Met Pro Arg Gly Tyr Ile Gln Asn Leu Leu Thr
             260                 265                 270        
 Gly Thr Ala Ser Phe Ser Ser Cys Val Leu His Phe Cys Glu Glu Leu
         275                 280                 285            
 Glu Glu Phe Trp Val Tyr Arg Ala Leu Leu Val Glu Leu Thr Lys Lys
     290                 295                 300                
 Leu Thr Tyr Cys Val Lys Ala Glu Leu Ile Pro Leu Met Glu Val Thr
 305                 310                 315                 320
 Glu Phe Xaa Arg Val Arg Ala Lys Asn Ser Tyr Thr Ser Ala Gly Tyr
                 325                 330                 335    
 Lys Ser Leu Met His Leu Ala Asn Ala Asn Pro Glu Val Pro Arg Lys
             340                 345                 350        
 Asp Asn
        



      <210> 1548
      <211> 302
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(302)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1548
 Gly Val Val Gly Ala Ala Ala Ser Gly Ala Gly Ser Arg Lys Ala Gly
   1               5                  10                  15    
 Leu Ala Gly Val Pro Gly Pro Pro Gly Arg Ala Asn Arg Glu Ser Pro
              20                  25                  30        
 Pro Gly Pro Val Ala Met Gly Arg Val Ile Arg Gly Gln Arg Lys Gly
          35                  40                  45            
 Ala Gly Ser Val Phe Arg Ala His Val Lys His Arg Lys Gly Ala Ala
      50                  55                  60                
 Arg Leu Arg Ala Val Asp Phe Ala Glu Arg His Gly Tyr Ile Lys Gly
  65                  70                  75                  80
 Ile Val Lys Asp Ile Ile His Asp Pro Gly Arg Gly Ala Pro Leu Ala
                  85                  90                  95    
 Lys Val Val Phe Arg Asp Ser Tyr Arg Phe Lys Lys Arg Thr Glu Leu
             100                 105                 110        
 Phe Ile Ala Ala Glu Gly Ile His Thr Gly Gln Phe Val Tyr Cys Gly
         115                 120                 125            
 Lys Lys Ala Gln Leu Asn Ile Gly Asn Val Leu Pro Val Gly Thr Met
     130                 135                 140                
 Pro Glu Gly Thr Ile Val Cys Cys Ala Leu Glu Glu Lys Pro Gly Asp
 145                 150                 155                 160
 Arg Gly Lys Leu Ala Arg Ala Ser Gly Asn Tyr Ala Thr Val Ile Ser
                 165                 170                 175    
 His Asn Pro Glu Thr Lys Lys Thr Arg Val Lys Leu Pro Phe Arg Val
             180                 185                 190        
 Gln Arg Arg Leu Ser Pro Ser Ala Asn Lys Ser Leu Trp Leu Val Leu
         195                 200                 205            
 Val Ala Gly Gly Trp Pro Glu Cys Asp Lys Pro Ile Leu Lys Ala Gly
     210                 215                 220                
 Arg Ala Val Pro Gln Ile Xaa Arg Gln Lys Arg Asn Cys Trp Pro Arg
 225                 230                 235                 240
 Val Thr Gly Val Trp Ala Met Asn Pro Phe Glu Ala Phe Phe Leu Lys
                 245                 250                 255    
 Gly Gly Asn Pro Pro Ala His Arg Gln Ser Pro Pro Pro Ile Arg Arg
             260                 265                 270        
 Asp Ala Pro Ala Gly Arg Lys Val Gly Leu Ile Ala Ala Arg Arg Thr
         275                 280                 285            
 Gly Arg Leu Arg Gly Thr Lys Thr Val Gln Glu Lys Glu Asn
     290                 295                 300        



      <210> 1549
      <211> 214
      <212> PRT
      <213> Homo sapiens


      <400> 1549
 Glu Gln Thr Val Tyr Cys Thr Arg Ile Asp Leu Gln Gln Lys Leu Val
   1               5                  10                  15    
 Phe Leu Arg Leu Glu Ala Phe Cys Leu Leu Ser Gln Gly Asp Pro Gly
              20                  25                  30        
 Ser Pro Met Met Cys Gln Leu Gln Gln Phe Asp Leu Trp Val Leu Arg
          35                  40                  45            
 Gly Val Leu Asn Phe Gly Gly Glu Thr Cys Pro Gly Leu Phe Leu Tyr
      50                  55                  60                
 Thr Lys Val Glu Asp Tyr Ser Lys Trp Ile Thr Ser Lys Ala Glu Arg
  65                  70                  75                  80
 Ala Gly Pro Pro Leu Ser Ser Leu His His Trp Glu Lys Leu Ile Ser
                  85                  90                  95    
 Phe Ser His His Gly Pro Asn Ala Thr Met Thr Gln Lys Thr Tyr Ser
             100                 105                 110        
 Asp Ser Glu Leu Gly His Val Gly Ser Tyr Leu Gln Gly Gln Arg Arg
         115                 120                 125            
 Thr Ile Thr His Ser Arg Leu Gly Asn Ser Ser Arg Asp Ser Leu Asp
     130                 135                 140                
 Val Arg Glu Lys Asp Val Lys Glu Ser Gly Arg Ser Pro Glu Ala Ser
 145                 150                 155                 160
 Val Gln Pro Leu Tyr Tyr Asp Tyr Tyr Gly Gly Glu Val Gly Glu Gly
                 165                 170                 175    
 Arg Ile Phe Ala Gly Gln Asn Arg Leu Tyr Gln Pro Glu Glu Ile Ile
             180                 185                 190        
 Leu Gly Ser Leu Arg Ala Cys Phe Leu Phe Ala Ala Val Ser Ser Pro
         195                 200                 205            
 Gly Ala Thr Pro Pro Asn
     210                



      <210> 1550
      <211> 473
      <212> PRT
      <213> Homo sapiens


      <400> 1550
 Ile Tyr Leu Leu Arg Thr Ser Leu His Arg Glu Arg Glu Gln Ala Gln
   1               5                  10                  15    
 Gln Leu His Gln Leu Leu Ala Leu Lys Glu Gln Glu His Arg Lys Glu
              20                  25                  30        
 Leu Glu Thr Arg Glu Phe Phe Thr Asp Ala Asp Phe Gln Asp Ala Leu
          35                  40                  45            
 Ala Lys Glu Ile Ala Lys Glu Glu Lys Lys His Glu Gln Met Ile Lys
      50                  55                  60                
 Glu Tyr Gln Glu Lys Ile Asp Val Leu Ser Gln Gln Tyr Met Asp Leu
  65                  70                  75                  80
 Glu Asn Glu Phe Arg Ile Ala Leu Thr Val Glu Ala Arg Arg Phe Gln
                  85                  90                  95    
 Asp Val Lys Asp Gly Phe Glu Asn Val Ala Thr Glu Leu Ala Lys Ser
             100                 105                 110        
 Lys His Ala Leu Ile Trp Ala Gln Arg Lys Glu Asn Glu Ser Ser Ser
         115                 120                 125            
 Leu Ile Lys Asp Leu Thr Cys Met Val Lys Glu Gln Lys Thr Lys Leu
     130                 135                 140                
 Ala Glu Val Ser Lys Leu Lys Gln Glu Thr Ala Ala Asn Leu Gln Asn
 145                 150                 155                 160
 Gln Ile Asn Thr Leu Glu Ile Leu Ile Glu Asp Asp Lys Gln Lys Ser
                 165                 170                 175    
 Ile Gln Ile Glu Leu Leu Lys His Glu Lys Val Gln Leu Ile Ser Glu
             180                 185                 190        
 Leu Ala Ala Lys Glu Ser Leu Ile Phe Gly Leu Arg Thr Glu Arg Lys
         195                 200                 205            
 Val Trp Gly His Glu Leu Ala Gln Gln Gly Ser Ser Leu Ala Gln Asn
     210                 215                 220                
 Arg Gly Lys Leu Glu Ala Gln Ile Glu Ser Leu Ser Arg Glu Asn Glu
 225                 230                 235                 240
 Cys Leu Arg Lys Thr Asn Glu Ser Asp Ser Asp Ala Leu Arg Ile Lys
                 245                 250                 255    
 Cys Lys Ile Ile Asp Asp Gln Thr Glu Thr Ile Arg Lys Leu Lys Asp
             260                 265                 270        
 Cys Leu Gln Glu Lys Asp Glu His Ile Lys Arg Leu Gln Glu Lys Ile
         275                 280                 285            
 Thr Glu Ile Glu Lys Cys Thr Gln Glu Gln Leu Asp Glu Lys Ser Ser
     290                 295                 300                
 Gln Leu Asp Glu Val Leu Glu Lys Leu Glu Arg His Asn Glu Arg Lys
 305                 310                 315                 320
 Glu Lys Leu Lys Gln Gln Leu Lys Gly Lys Glu Val Glu Leu Glu Glu
                 325                 330                 335    
 Ile Arg Lys Ala Tyr Ser Thr Leu Asn Arg Lys Trp His Asp Lys Gly
             340                 345                 350        
 Glu Leu Leu Cys His Leu Glu Thr Gln Val Lys Glu Val Lys Glu Lys
         355                 360                 365            
 Phe Glu Asn Lys Glu Lys Lys Leu Lys Ala Glu Arg Asp Lys Ser Ile
     370                 375                 380                
 Glu Leu Gln Lys Asn Ala Met Glu Lys Leu His Ser Met Asp Asp Ala
 385                 390                 395                 400
 Phe Lys Arg Gln Val Asp Ala Ile Val Glu Ala His Gln Ala Glu Ile
                 405                 410                 415    
 Ala Gln Leu Ala Asn Glu Lys Gln Lys Cys Ile Asp Ser Ala Asn Leu
             420                 425                 430        
 Lys Val His Gln Ile Glu Lys Glu Met Arg Glu Leu Leu Glu Glu Thr
         435                 440                 445            
 Cys Lys Asn Ile Lys Thr Met Glu Ala Lys Ile Lys Gln Leu Ala Phe
     450                 455                 460                
 Ala Leu Asn Glu Ile Gln Gln Asp Met
 465                 470            



      <210> 1551
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 1551
 Leu Thr Leu Arg Pro Pro Ser Leu Ala Ala Pro Tyr Ala Pro Val Gln
   1               5                  10                  15    
 Ser Trp Gln His Gln Pro Glu Lys Leu Ile Phe Glu Ser Cys Gly Tyr
              20                  25                  30        
 Glu Ala Asn Tyr Leu Gly Ser Met Leu Ile Lys Asp Leu Arg Gly Thr
          35                  40                  45            
 Glu Ser Thr Gln Asp Ala Cys Ala Lys Met Arg Lys Ser Thr Glu His
      50                  55                  60                
 Met Lys Lys Ile Pro Thr Ile Ile Leu Ser Ile Thr Tyr Lys Gly Val
  65                  70                  75                  80
 Lys Phe Ile Asp Ala Ser Asn Lys Asn Val Ile Ala Glu His Glu Ile
                  85                  90                  95    
 Arg Asn Ile Ser Cys Ala Ala Gln Asp Pro Glu Asp Leu Cys Thr Phe
             100                 105                 110        
 Ala Tyr Ile Thr Lys Gly Pro Gly Asp
         115                 120    



      <210> 1552
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 1552
 Leu Thr Leu Arg Pro Pro Ser Leu Ala Ala Pro Tyr Ala Pro Val Gln
   1               5                  10                  15    
 Ser Trp Gln His Gln Pro Glu Lys Leu Ile Phe Glu Ser Cys Gly Tyr
              20                  25                  30        
 Glu Ala Asn Tyr Leu Gly Ser Met Leu Ile Lys Asp Leu Arg Gly Thr
          35                  40                  45            
 Glu Ser Thr Gln Asp Ala Cys Ala Lys Met Arg Lys Ser Thr Glu His
      50                  55                  60                
 Met Lys Lys Ile Pro Thr Ile Ile Leu Ser Ile Thr Tyr Lys Gly Val
  65                  70                  75                  80
 Lys Phe Ile Asp Ala Ser Asn Lys Asn Val Ile Ala Glu His Glu Ile
                  85                  90                  95    
 Arg Asn Ile Ser Cys Ala Ala Gln Asp Pro Glu Asp Leu Cys Thr Phe
             100                 105                 110        
 Ala Tyr Ile Thr Lys Gly Pro Gly Asp
         115                 120    



      <210> 1553
      <211> 264
      <212> PRT
      <213> Homo sapiens


      <400> 1553
 Thr Lys Leu Lys Lys Glu Gln Glu Asn Leu Leu Lys Gln Arg Trp Glu
   1               5                  10                  15    
 Leu Glu Arg Leu Glu Glu Glu Arg Lys Gln Met Glu Ala Phe Arg Gln
              20                  25                  30        
 Lys Ala Glu Leu Gly Arg Phe Leu Arg His Gln Tyr Asn Ala Gln Leu
          35                  40                  45            
 Ser Arg Arg Thr Gln Gln Ile Gln Glu Glu Leu Glu Ala Asp Arg Arg
      50                  55                  60                
 Ile Leu Gln Ala Leu Leu Glu Lys Glu Asp Glu Ser Gln Arg Leu His
  65                  70                  75                  80
 Leu Ala Arg Arg Glu Gln Val Met Ala Asp Val Ala Trp Met Lys Gln
                  85                  90                  95    
 Ala Ile Glu Glu Gln Leu Gln Leu Glu Arg Ala Arg Glu Ala Glu Leu
             100                 105                 110        
 Gln Met Leu Leu Arg Glu Glu Ala Lys Glu Met Trp Glu Lys Arg Glu
         115                 120                 125            
 Ala Glu Trp Ala Arg Glu Arg Ser Ala Arg Asp Arg Leu Met Ser Glu
     130                 135                 140                
 Val Leu Thr Gly Arg Gln Gln Gln Ile Gln Glu Lys Ile Glu Gln Asn
 145                 150                 155                 160
 Arg Arg Ala Gln Glu Glu Ser Leu Lys His Arg Glu Gln Leu Ile Arg
                 165                 170                 175    
 Asn Leu Glu Glu Val Arg Glu Leu Ala Arg Arg Glu Lys Glu Glu Ser
             180                 185                 190        
 Glu Lys Leu Lys Ser Ala Arg Lys Gln Glu Leu Glu Ala Gln Val Ala
         195                 200                 205            
 Glu Arg Arg Leu Gln Ala Trp Glu Ala Asp Gln Gln Glu Glu Glu Glu
     210                 215                 220                
 Glu Glu Glu Ala Arg Arg Val Glu Gln Leu Ser Asp Ala Leu Leu Gln
 225                 230                 235                 240
 Gln Glu Ala Glu Thr Met Ala Glu Gln Gly Tyr Arg Pro Lys Pro Tyr
                 245                 250                 255    
 Gly His Pro Lys Ile Ala Trp Asn
             260                



      <210> 1554
      <211> 298
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(298)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1554
 Val Tyr Thr Tyr Leu Arg Leu Ile Val Asp His His Gly Thr Ala Gln
   1               5                  10                  15    
 Leu Gln Ala Leu Arg Gln Lys Glu Val Asp Phe Cys Ile Ser Leu Leu
              20                  25                  30        
 Arg Glu Arg Phe Met Glu Cys Leu Met Ile Gly Arg Asp Leu Val Arg
          35                  40                  45            
 Leu Leu Gln Asn Val Ala Arg Ile Pro Glu Phe Glu Leu Leu Trp Lys
      50                  55                  60                
 Asp Ile Ile His Asn Pro Gln Ala Leu Ser Pro Gln Phe Thr Gly Ile
  65                  70                  75                  80
 Leu Gln Leu Leu Gln Ser Arg Thr Ser Arg Lys Phe Leu Ala Cys Arg
                  85                  90                  95    
 Leu Thr Pro Asp Met Glu Thr Lys Leu Leu Phe Met Thr Ser Arg Val
             100                 105                 110        
 Arg Phe Gly Gln Gln Lys Arg Tyr Gln Asp Trp Phe Gln Arg Gln Tyr
         115                 120                 125            
 Leu Ser Thr Pro Asp Ser Gln Ser Leu Arg Cys Asp Leu Ile Arg Tyr
     130                 135                 140                
 Ile Cys Gly Val Val His Pro Ser Asn Glu Val Leu Ser Ser Asp Ile
 145                 150                 155                 160
 Leu Pro Arg Trp Ala Ile Ile Gly Trp Leu Leu Thr Thr Cys Thr Ser
                 165                 170                 175    
 Asn Val Ala Ala Ser Asn Ala Lys Leu Ala Leu Phe Tyr Asp Trp Leu
             180                 185                 190        
 Phe Phe Ser Pro Asp Lys Asp Ser Ile Met Asn Ile Glu Pro Ala Ile
         195                 200                 205            
 Leu Val Met His His Ser Met Lys Pro His Pro Ala Ile Thr Ala Thr
     210                 215                 220                
 Leu Leu Asp Phe Met Cys Arg Ile Ile Pro Asn Phe Tyr Pro Pro Leu
 225                 230                 235                 240
 Glu Gly His Val Arg Gln Gly Val Phe Ser Ser Leu Asn His Ile Val
                 245                 250                 255    
 Glu Lys Arg Val Leu Arg Val Xaa Lys Val Leu Ala Leu Pro Gln Thr
             260                 265                 270        
 Ala Gly His Met Ser Ser Trp Leu Leu Glu Glu Phe Leu Ser Cys His
         275                 280                 285            
 Arg Ile Thr Lys Thr Pro Ser Ser Pro Val
     290                 295            



      <210> 1555
      <211> 298
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(298)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1555
 Val Tyr Thr Tyr Leu Arg Leu Ile Val Asp His His Gly Thr Ala Gln
   1               5                  10                  15    
 Leu Gln Ala Leu Arg Gln Lys Glu Val Asp Phe Cys Ile Ser Leu Leu
              20                  25                  30        
 Arg Glu Arg Phe Met Glu Cys Leu Met Ile Gly Arg Asp Leu Val Arg
          35                  40                  45            
 Leu Leu Gln Asn Val Ala Arg Ile Pro Glu Phe Glu Leu Leu Trp Lys
      50                  55                  60                
 Asp Ile Ile His Asn Pro Gln Ala Leu Ser Pro Gln Phe Thr Gly Ile
  65                  70                  75                  80
 Leu Gln Leu Leu Gln Ser Arg Thr Ser Arg Lys Phe Leu Ala Cys Arg
                  85                  90                  95    
 Leu Thr Pro Asp Met Glu Thr Lys Leu Leu Phe Met Thr Ser Arg Val
             100                 105                 110        
 Arg Phe Gly Gln Gln Lys Arg Tyr Gln Asp Trp Phe Gln Arg Gln Tyr
         115                 120                 125            
 Leu Ser Thr Pro Asp Ser Gln Ser Leu Arg Cys Asp Leu Ile Arg Tyr
     130                 135                 140                
 Ile Cys Gly Val Val His Pro Ser Asn Glu Val Leu Ser Ser Asp Ile
 145                 150                 155                 160
 Leu Pro Arg Trp Ala Ile Ile Gly Trp Leu Leu Thr Thr Cys Thr Ser
                 165                 170                 175    
 Asn Val Ala Ala Ser Asn Ala Lys Leu Ala Leu Phe Tyr Asp Trp Leu
             180                 185                 190        
 Phe Phe Ser Pro Asp Lys Asp Ser Ile Met Asn Ile Glu Pro Ala Ile
         195                 200                 205            
 Leu Val Met His His Ser Met Lys Pro His Pro Ala Ile Thr Ala Thr
     210                 215                 220                
 Leu Leu Asp Phe Met Cys Arg Ile Ile Pro Asn Phe Tyr Pro Pro Leu
 225                 230                 235                 240
 Glu Gly His Val Arg Gln Gly Val Phe Ser Ser Leu Asn His Ile Val
                 245                 250                 255    
 Glu Lys Arg Val Leu Arg Val Xaa Lys Val Leu Ala Leu Pro Gln Thr
             260                 265                 270        
 Ala Gly His Met Ser Ser Trp Leu Leu Glu Glu Phe Leu Ser Cys His
         275                 280                 285            
 Arg Ile Thr Lys Thr Pro Ser Ser Pro Val
     290                 295            



      <210> 1556
      <211> 82
      <212> PRT
      <213> Homo sapiens


      <400> 1556
 Tyr Asn Ile Glu Glu Gln Gln Asn Lys Arg Thr Arg Gln Ser Asn Arg
   1               5                  10                  15    
 His Arg Pro Thr Pro Pro Pro Glu Pro Pro Asn Pro Glu Trp Thr Pro
              20                  25                  30        
 Lys Pro Thr Pro Pro Thr Lys Pro Ser Ser Pro Gln Gly Glu Gly Pro
          35                  40                  45            
 Gly Trp Thr Gly Gly Pro Ala Pro His Ala Gly Ala Ala Pro Pro Phe
      50                  55                  60                
 Pro Ser Pro Ala Asn Pro Thr Leu Phe Pro Ser Leu Thr Thr Gly Gly
  65                  70                  75                  80
 Lys Val
        



      <210> 1557
      <211> 115
      <212> PRT
      <213> Homo sapiens


      <400> 1557
 Met Leu Gln Ala Pro Pro Leu Thr Ser Leu Gln Leu Ser Leu Lys Tyr
   1               5                  10                  15    
 Leu Phe Ala Val Arg Trp Ser Pro Val Arg Pro Leu Val Phe Ala Ala
              20                  25                  30        
 Ala Ser Gly Lys Gly Asp Val Gln Leu Phe Asp Leu Gln Lys Ser Ser
          35                  40                  45            
 Gln Lys Pro Thr Val Leu Ile Lys Gln Thr Gln Asp Glu Ser Pro Val
      50                  55                  60                
 Tyr Cys Leu Glu Phe Asn Ser Gln Gln Thr Gln Leu Leu Ala Ala Gly
  65                  70                  75                  80
 Asp Ala Gln Gly Thr Val Lys Val Trp Gln Leu Ser Thr Glu Phe Thr
                  85                  90                  95    
 Glu Gln Gly Pro Arg Glu Ala Glu Asp Leu Asp Cys Leu Ala Ala Glu
             100                 105                 110        
 Val Ala Ala
         115



      <210> 1558
      <211> 152
      <212> PRT
      <213> Homo sapiens


      <400> 1558
 Arg Leu Arg Glu Asp Asp Arg Arg Val Arg Leu Arg Glu Asp Asp Arg
   1               5                  10                  15    
 Arg Val Arg Leu Arg Glu Asp Asp Arg Arg Val Arg Leu Arg Glu Asp
              20                  25                  30        
 Asp Arg Arg Gly Phe Arg His Gly Arg Leu Trp Arg Ala Ala Ala Met
          35                  40                  45            
 Ala Leu Arg Tyr Pro Met Ala Val Gly Leu Asn Lys Gly His Lys Val
      50                  55                  60                
 Thr Lys Asn Val Ser Lys Pro Arg His Ser Arg Arg Arg Gly Arg Leu
  65                  70                  75                  80
 Thr Lys His Thr Lys Phe Val Arg Asp Met Ile Arg Glu Val Cys Gly
                  85                  90                  95    
 Phe Ala Pro Tyr Glu Arg Arg Ala Met Glu Leu Leu Lys Val Ser Lys
             100                 105                 110        
 Asp Lys Arg Ala Leu Lys Phe Ile Lys Lys Arg Val Gly Thr His Ile
         115                 120                 125            
 Arg Ala Lys Arg Lys Arg Glu Glu Leu Ser Asn Val Leu Ala Ala Met
     130                 135                 140                
 Arg Lys Ala Ala Ala Lys Lys Asp
 145                 150        



      <210> 1559
      <211> 160
      <212> PRT
      <213> Homo sapiens


      <400> 1559
 Gln Phe Thr Glu Ser His Leu Cys Ser Leu Met Gly Asp Asn Pro Phe
   1               5                  10                  15    
 Gln Pro Lys Ser Asn Ser Lys Met Ala Glu Leu Phe Met Glu Cys Glu
              20                  25                  30        
 Glu Glu Glu Leu Glu Pro Trp Gln Lys Lys Val Lys Glu Val Glu Asp
          35                  40                  45            
 Asp Asp Asp Asp Glu Pro Ile Phe Val Gly Glu Ile Ser Ser Ser Lys
      50                  55                  60                
 Pro Ala Ile Ser Asn Ile Leu Asn Arg Val Asn Pro Ser Ser Tyr Ser
  65                  70                  75                  80
 Arg Gly Leu Lys Asn Gly Ala Leu Ser Arg Gly Ile Thr Ala Ala Phe
                  85                  90                  95    
 Lys Pro Thr Ser Gln His Tyr Thr Asn Pro Thr Ser Asn Pro Val Pro
             100                 105                 110        
 Ala Ser Pro Ile Asn Phe His Pro Glu Ser Arg Ser Ser Asp Ser Ser
         115                 120                 125            
 Val Ile Gly Gln Pro Phe Ser Lys Pro Val Ser Val Ser Lys Thr Ile
     130                 135                 140                
 Arg Pro Ala Gln Gly Ser Ile Gly Cys Cys Leu Ser Ile Ser Thr Val
 145                 150                 155                 160





      <210> 1560
      <211> 1053
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1053)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1560
 Met Ser Arg Arg Lys Gln Ala Lys Pro Gln His Ile Asn Ser Glu Glu
   1               5                  10                  15    
 Asp Gln Gly Glu Gln Gln Pro Gln Gln Gln Thr Pro Glu Phe Ala Asp
              20                  25                  30        
 Ala Ala Pro Ala Ala Pro Ala Ala Gly Glu Leu Gly Ala Pro Val Asn
          35                  40                  45            
 His Pro Gly Asn Asp Glu Val Ala Ser Glu Asp Glu Ala Thr Val Lys
      50                  55                  60                
 Arg Leu Arg Arg Glu Glu Thr His Val Cys Glu Lys Cys Cys Ala Glu
  65                  70                  75                  80
 Phe Phe Ser Ile Ser Glu Phe Leu Glu His Lys Lys Asn Cys Thr Lys
                  85                  90                  95    
 Asn Pro Pro Val Leu Ile Met Asn Asp Ser Glu Gly Pro Val Pro Ser
             100                 105                 110        
 Glu Asp Phe Ser Gly Ala Val Leu Ser His Gln Pro Thr Ser Pro Gly
         115                 120                 125            
 Ser Lys Asp Cys His Arg Glu Asn Gly Gly Ser Ser Glu Asp Met Lys
     130                 135                 140                
 Glu Lys Pro Asp Ala Glu Ser Val Val Tyr Leu Lys Thr Glu Thr Ala
 145                 150                 155                 160
 Leu Pro Pro Thr Pro Gln Asp Ile Ser Tyr Leu Ala Lys Gly Lys Val
                 165                 170                 175    
 Ala Asn Thr Asn Val Thr Leu Gln Ala Leu Arg Gly Thr Lys Val Ala
             180                 185                 190        
 Val Asn Gln Arg Ser Ala Asp Ala Leu Pro Ala Pro Val Pro Gly Ala
         195                 200                 205            
 Asn Ser Ile Pro Trp Val Leu Glu Gln Ile Leu Cys Leu Gln Gln Gln
     210                 215                 220                
 Gln Leu Gln Gln Ile Gln Leu Thr Glu Gln Ile Arg Ile Gln Val Asn
 225                 230                 235                 240
 Met Trp Ala Ser His Ala Leu His Ser Ser Gly Ala Gly Ala Asp Thr
                 245                 250                 255    
 Leu Lys Thr Leu Gly Ser His Met Ser Gln Gln Val Ser Ala Ala Val
             260                 265                 270        
 Ala Leu Leu Ser Gln Lys Ala Gly Ser Gln Gly Leu Ser Leu Asp Ala
         275                 280                 285            
 Leu Lys Gln Ala Lys Leu Pro His Ala Asn Ile Pro Ser Ala Thr Ser
     290                 295                 300                
 Ser Leu Ser Pro Gly Leu Ala Pro Phe Thr Leu Lys Pro Asp Gly Thr
 305                 310                 315                 320
 Arg Val Leu Pro Asn Val Met Ser Arg Leu Pro Ser Ala Leu Leu Pro
                 325                 330                 335    
 Gln Ala Pro Gly Ser Val Leu Phe Gln Ser Pro Phe Ser Thr Val Ala
             340                 345                 350        
 Leu Asp Thr Ser Lys Lys Gly Lys Gly Lys Pro Pro Asn Ile Ser Ala
         355                 360                 365            
 Val Asp Val Lys Pro Lys Asp Glu Ala Ala Leu Tyr Lys His Lys Cys
     370                 375                 380                
 Lys Tyr Cys Ser Lys Val Phe Gly Thr Asp Ser Ser Leu Gln Ile His
 385                 390                 395                 400
 Leu Arg Ser His Thr Gly Glu Arg Pro Phe Val Cys Ser Val Cys Gly
                 405                 410                 415    
 His Arg Phe Thr Thr Lys Gly Asn Leu Lys Val His Phe His Arg His
             420                 425                 430        
 Pro Gln Val Lys Ala Asn Pro Gln Leu Phe Ala Glu Phe Gln Asp Lys
         435                 440                 445            
 Val Ala Ala Gly Asn Gly Ile Pro Tyr Ala Leu Ser Val Pro Asp Pro
     450                 455                 460                
 Ile Asp Glu Pro Ser Leu Ser Leu Asp Ser Lys Pro Val Leu Val Thr
 465                 470                 475                 480
 Thr Ser Val Gly Leu Pro Gln Asn Leu Ser Ser Gly Thr Asn Pro Lys
                 485                 490                 495    
 Asp Leu Thr Gly Gly Ser Leu Pro Gly Asp Leu Gln Pro Gly Pro Ser
             500                 505                 510        
 Pro Glu Ser Glu Gly Gly Pro Thr Leu Pro Gly Val Gly Pro Asn Tyr
         515                 520                 525            
 Asn Ser Pro Arg Ala Gly Gly Phe Gln Gly Ser Gly Thr Pro Glu Pro
     530                 535                 540                
 Gly Ser Glu Thr Leu Lys Leu Gln Gln Leu Val Glu Asn Ile Asp Lys
 545                 550                 555                 560
 Ala Thr Thr Asp Pro Asn Glu Cys Leu Ile Cys His Arg Val Leu Ser
                 565                 570                 575    
 Cys Gln Ser Ser Leu Lys Met His Tyr Arg Thr His Thr Gly Glu Arg
             580                 585                 590        
 Pro Phe Gln Cys Lys Ile Cys Gly Arg Ala Phe Ser Thr Lys Gly Asn
         595                 600                 605            
 Leu Lys Thr His Leu Gly Val His Arg Thr Asn Thr Ser Ile Lys Thr
     610                 615                 620                
 Gln His Ser Cys Pro Ile Cys Gln Lys Lys Phe Thr Asn Ala Val Met
 625                 630                 635                 640
 Leu Gln Gln His Ile Arg Met His Met Gly Gly Gln Ile Pro Asn Thr
                 645                 650                 655    
 Pro Leu Pro Glu Asn Pro Cys Asp Phe Thr Gly Ser Glu Pro Met Thr
             660                 665                 670        
 Val Gly Glu Asn Gly Ser Thr Gly Ala Ile Cys His Asp Asp Val Ile
         675                 680                 685            
 Glu Ser Ile Asp Val Glu Glu Val Ser Ser Gln Glu Ala Pro Ser Ser
     690                 695                 700                
 Ser Ser Lys Val Pro Thr Pro Leu Pro Ser Ile His Ser Ala Ser Pro
 705                 710                 715                 720
 Thr Leu Gly Phe Ala Met Met Ala Ser Leu Asp Ala Pro Gly Lys Ala
                 725                 730                 735    
 Gly Pro Ala Pro Phe Asn Leu Gln Arg Gln Gly Ser Arg Glu Asn Gly
             740                 745                 750        
 Ser Val Glu Ser Asp Gly Leu Thr Asn Asp Ser Ser Ser Leu Met Gly
         755                 760                 765            
 Asp Gln Glu Tyr Gln Ser Arg Ser Pro Asp Ile Leu Glu Thr Thr Ser
     770                 775                 780                
 Phe Gln Ala Leu Ser Pro Ala Asn Ser Gln Ala Glu Ser Ile Lys Ser
 785                 790                 795                 800
 Lys Ser Pro Asp Ala Gly Ser Lys Ala Glu Ser Ser Glu Asn Ser Arg
                 805                 810                 815    
 Thr Glu Met Glu Gly Arg Ser Ser Leu Pro Ser Thr Phe Ile Arg Ala
             820                 825                 830        
 Pro Pro Thr Tyr Val Lys Val Glu Val Pro Gly Thr Phe Val Gly Pro
         835                 840                 845            
 Ser Thr Leu Ser Pro Gly Met Thr Pro Leu Leu Ala Ala Gln Pro Arg
     850                 855                 860                
 Arg Gln Ala Lys Gln His Gly Cys Thr Arg Cys Gly Lys Asn Phe Ser
 865                 870                 875                 880
 Ser Ala Ser Ala Leu Gln Ile His Glu Arg Thr His Thr Gly Glu Lys
                 885                 890                 895    
 Pro Phe Val Cys Asn Ile Cys Gly Arg Ala Phe Thr Thr Lys Gly Asn
             900                 905                 910        
 Leu Lys Val His Tyr Met Thr His Gly Ala Asn Asn Asn Ser Ala Arg
         915                 920                 925            
 Arg Gly Arg Lys Leu Ala Ile Glu Asn Thr Met Ala Leu Leu Gly Thr
     930                 935                 940                
 Asp Gly Lys Arg Val Ser Glu Ile Phe Pro Lys Glu Ile Leu Ala Pro
 945                 950                 955                 960
 Ser Val Asn Val Asp Pro Val Val Trp Asn Gln Tyr Thr Ser Met Leu
                 965                 970                 975    
 Asn Gly Gly Leu Ala Val Lys Thr Asn Glu Ile Ser Val Ile Gln Ser
             980                 985                 990        
 Gly Xaa Val Pro Thr Leu Pro Val Ser Leu Gly Ala Thr Ser Val Val
         995                1000                1005            
 Asn Asn Ala Thr Val Ser Lys Met Asp Gly Ser Gln Ser Gly Ile Ser
    1010                1015                1020                
 Ala Asp Val Glu Lys Pro Ser Ala Thr Asp Gly Val Pro Lys His Gln
1025                1030                1035                1040
 Phe Pro His Phe Leu Glu Glu Asn Lys Ile Ala Val Ser
                1045                1050            



      <210> 1561
      <211> 194
      <212> PRT
      <213> Homo sapiens


      <400> 1561
 Arg Val Ala Leu Glu Trp Cys Gln Phe Ala Arg Leu Ser Ala Leu Arg
   1               5                  10                  15    
 Ile Gln Ala Leu Lys Leu Trp Glu Lys Lys Trp Val Thr Val Gly Asp
              20                  25                  30        
 Thr Ser Leu Arg Ile Phe Lys Trp Val Pro Val Thr Asp Ser Lys Glu
          35                  40                  45            
 Lys Glu Lys Ser Lys Ser Asn Ser Ser Ala Ala Arg Glu Pro Asn Gly
      50                  55                  60                
 Phe Pro Ser Asp Ala Ser Ala Asn Ser Ser Leu Leu Leu Glu Phe Gln
  65                  70                  75                  80
 Asp Glu Asn Ser Asn Gln Ser Ser Val Ser Asp Val Tyr Gln Leu Lys
                  85                  90                  95    
 Val Asp Ser Ser Thr Asn Ser Ser Pro Ser Pro Gln Gln Ser Glu Ser
             100                 105                 110        
 Leu Ser Pro Ala His Thr Ser Asp Phe Arg Thr Asp Asp Ser Gln Pro
         115                 120                 125            
 Pro Thr Leu Gly Gln Glu Ile Leu Glu Glu Pro Ser Leu Pro Ser Ser
     130                 135                 140                
 Glu Val Ala Asp Glu Pro Pro Thr Leu Thr Lys Glu Glu Pro Val Pro
 145                 150                 155                 160
 Leu Glu Thr Gln Val Val Glu Glu Glu Glu Asp Ser Gly Ala Pro Pro
                 165                 170                 175    
 Leu Lys Arg Phe Cys Val Asp Gln Pro Thr Val Pro Gln Thr Ala Ser
             180                 185                 190        
 Glu Ser
        



      <210> 1562
      <211> 81
      <212> PRT
      <213> Homo sapiens


      <400> 1562
 Pro Leu Ala His Val Leu Ala Ser Leu Pro Gln Phe Pro His Leu Met
   1               5                  10                  15    
 Asp Leu Leu Ala Lys Asp Asp Gln Asn Gly Glu Ala Glu Ala Phe Lys
              20                  25                  30        
 Ala Glu Ile Lys Lys Thr Asp Val Lys Glu Glu Lys Arg Lys Lys Glu
          35                  40                  45            
 Leu Asn Glu Ile Leu Lys Ser Thr Val Ser Ser Asn Asp Lys Lys Thr
      50                  55                  60                
 Lys Gly Arg Thr Gly Trp Pro Gln His Val Trp Ala Leu Glu Leu Lys
  65                  70                  75                  80
 Gln
    



      <210> 1563
      <211> 166
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(166)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1563
 Phe Arg Ala Gly Arg Lys Pro Leu Pro Ser Thr Ala Ala Ala Ser Ser
   1               5                  10                  15    
 Pro Gly Ser Ala Ala Ala Ala Thr Ala Ala Leu Cys Pro Pro Ala Arg
              20                  25                  30        
 Leu Ser Thr Pro Ser Met Ser Gly Leu Arg Val Tyr Ser Thr Ser Val
          35                  40                  45            
 Thr Gly Ser Arg Glu Ile Lys Ser Gln Gln Ser Glu Val Thr Arg Ile
      50                  55                  60                
 Leu Asp Gly Lys Arg Ile Gln Tyr Gln Leu Val Asp Ile Ser Gln Asp
  65                  70                  75                  80
 Asn Ala Leu Arg Asp Glu Met Arg Ala Leu Ala Gly Asn Pro Lys Ala
                  85                  90                  95    
 Thr Pro Pro Gln Ile Val Asn Gly Asp Gln Tyr Cys Gly Asp Tyr Glu
             100                 105                 110        
 Leu Phe Val Glu Ala Val Glu Gln Asn Thr Leu Gln Glu Phe Leu Lys
         115                 120                 125            
 Leu Ala Xaa Val Lys Pro Val Gln Ser Ser Pro Ala Gly Leu His His
     130                 135                 140                
 His Thr Pro Pro Ser Leu His Leu Ala Met Lys Asp Leu Leu Thr Asn
 145                 150                 155                 160
 Ser Leu Ser Phe Leu Thr
                 165    



      <210> 1564
      <211> 462
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(462)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1564
 Leu Gln Glu Val Lys Ala Arg Arg Asn Thr Leu His Lys Glu Lys Asp
   1               5                  10                  15    
 His Leu Val Asn Asp Tyr Glu Gln Asn Met Lys Leu Leu Gln Thr Lys
              20                  25                  30        
 Tyr Asp Ala Asp Ile Asn Leu Leu Lys Gln Glu His Ala Leu Ser Ala
          35                  40                  45            
 Ser Lys Ala Ser Ser Met Ile Glu Glu Leu Glu Gln Asn Val Cys Gln
      50                  55                  60                
 Leu Lys Gln Gln Leu Gln Glu Ser Glu Leu Gln Arg Lys Gln Gln Leu
  65                  70                  75                  80
 Arg Asp Gln Glu Asn Lys Phe Gln Met Glu Lys Ser His Leu Lys His
                  85                  90                  95    
 Ile Tyr Glu Lys Lys Ala His Asp Leu Gln Ser Glu Leu Asp Glu Arg
             100                 105                 110        
 Lys Arg Arg Tyr Ser Lys Glu Asn Ser Xaa Ile Xaa Gly Ser Phe Glu
         115                 120                 125            
 Met Glu Lys Val Glu Ala Asp Leu Thr Arg Ser Lys Ser Leu Arg Glu
     130                 135                 140                
 Lys Gln Ser Lys Glu Phe Leu Trp Gln Leu Glu Asp Ile Arg Gln Arg
 145                 150                 155                 160
 Tyr Glu Gln Gln Ile Val Glu Leu Lys Leu Glu His Glu Gln Glu Lys
                 165                 170                 175    
 Thr His Leu Leu Gln Gln His Asn Ala Glu Lys Asp Ser Leu Val Arg
             180                 185                 190        
 Asp His Glu Arg Glu Ile Glu Asn Leu Glu Lys Gln Leu Arg Ala Ala
         195                 200                 205            
 Asn Met Glu His Glu Asn Gln Ile Gln Glu Phe Lys Lys Arg Asp Ala
     210                 215                 220                
 Gln Val Ile Ala Asp Met Glu Ala Gln Val His Lys Leu Arg Glu Glu
 225                 230                 235                 240
 Leu Ile Asn Val Asn Ser Gln Arg Lys Gln Gln Leu Val Glu Leu Gly
                 245                 250                 255    
 Leu Leu Arg Glu Glu Glu Lys Gln Arg Ala Thr Arg Glu His Glu Ile
             260                 265                 270        
 Val Val Asn Lys Leu Lys Ala Glu Ser Glu Lys Met Lys Ile Glu Leu
         275                 280                 285            
 Lys Lys Thr His Ala Ala Glu Thr Glu Met Thr Leu Glu Lys Ala Asn
     290                 295                 300                
 Ser Lys Leu Lys Gln Ile Glu Lys Glu Tyr Thr Gln Lys Leu Ala Lys
 305                 310                 315                 320
 Ser Ser Gln Ile Ile Ala Glu Leu Gln Thr Thr Ile Ser Ser Leu Lys
                 325                 330                 335    
 Glu Glu Asn Ser Gln Gln Gln Leu Ala Ala Glu Arg Arg Leu Gln Asp
             340                 345                 350        
 Val Arg Gln Lys Phe Glu Asp Glu Lys Lys Gln Leu Ile Arg Asp Asn
         355                 360                 365            
 Asp Gln Ala Ile Lys Val Leu Gln Asp Glu Leu Glu Asn Arg Ser Asn
     370                 375                 380                
 Gln Val Arg Cys Ala Glu Lys Lys Leu Gln His Lys Glu Leu Glu Ser
 385                 390                 395                 400
 Gln Glu Gln Ile Thr Tyr Ile Arg Gln Glu Tyr Glu Thr Lys Leu Lys
                 405                 410                 415    
 Gly Leu Met Pro Ala Ser Leu Arg Gln Glu Leu Glu Asp Thr Ile Ser
             420                 425                 430        
 Ser Leu Lys Ser Gln Val Asn Phe Leu Gln Lys Arg Ala Ser Ile Leu
         435                 440                 445            
 Gln Glu Glu Leu Thr Thr Tyr Gln Gly Arg Arg Tyr Ser Pro
     450                 455                 460        



      <210> 1565
      <211> 382
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(382)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1565
 Glu Ala Leu His Leu Ala His Phe Gly Leu Thr Gly Phe Thr Gln Thr
   1               5                  10                  15    
 His Cys Ala Arg Ala Trp Gly Gly Gln Thr Arg Lys Arg Arg Arg Val
              20                  25                  30        
 Pro Arg Asp Pro Gly Gly Ala Asn Cys Ala Gly Gly Gly Val Ser Ala
          35                  40                  45            
 Asp Thr Ser Gly Leu Ala Ala Ala Ala Arg Gly Pro Pro Thr Leu Gly
      50                  55                  60                
 Phe Arg Glu Arg Arg Ser Ala Arg Ser Leu Asp Arg Ile Arg Pro Ile
  65                  70                  75                  80
 Leu Val Leu Met Val Asp Lys Lys Leu Val Val Val Phe Gly Gly Thr
                  85                  90                  95    
 Gly Ala Gln Gly Gly Ser Val Ala Arg Thr Leu Leu Glu Asp Gly Thr
             100                 105                 110        
 Phe Lys Val Arg Val Val Thr Arg Asn Pro Arg Lys Lys Ala Ala Lys
         115                 120                 125            
 Glu Leu Arg Leu Gln Gly Ala Glu Val Val Gln Gly Asp Gln Asp Asp
     130                 135                 140                
 Gln Val Ile Met Glu Leu Ala Leu Asn Gly Ala Tyr Ala Thr Phe Ile
 145                 150                 155                 160
 Val Thr Asn Tyr Trp Glu Ser Cys Ser Gln Glu Gln Glu Val Lys Gln
                 165                 170                 175    
 Gly Lys Leu Leu Ala Asp Leu Ala Arg Arg Leu Gly Leu His Tyr Val
             180                 185                 190        
 Val Tyr Ser Gly Leu Glu Asn Ile Lys Lys Leu Thr Ala Gly Arg Leu
         195                 200                 205            
 Ala Ala Ala His Phe Asp Gly Lys Gly Glu Val Glu Glu Tyr Phe Arg
     210                 215                 220                
 Asp Ile Gly Val Pro Met Thr Ser Val Arg Leu Pro Cys Tyr Phe Glu
 225                 230                 235                 240
 Asn Leu Leu Ser His Phe Leu Pro Gln Lys Ala Pro Asp Gly Lys Ser
                 245                 250                 255    
 Tyr Leu Leu Ser Leu Pro Thr Gly Asp Val Pro Met Asp Gly Met Ser
             260                 265                 270        
 Val Ser Asp Leu Gly Pro Val Val Leu Ser Leu Leu Lys Met Pro Glu
         275                 280                 285            
 Lys Tyr Val Gly Gln Asn Ile Gly Leu Ser Thr Cys Arg His Thr Ala
     290                 295                 300                
 Glu Glu Tyr Ala Ala Leu Leu Thr Lys His Pro Ala Arg Ser Cys Thr
 305                 310                 315                 320
 Met Pro Arg Xaa Leu Leu Arg Thr Thr Lys Ser Leu Ala Phe Pro Val
                 325                 330                 335    
 Pro Gly Thr Trp Leu Asn Met Phe Arg Phe Tyr Ala Leu Arg Pro Asp
             340                 345                 350        
 Arg Asp Ile Glu Leu Thr Leu Arg Leu Asn Pro Lys Ala Leu Thr Leu
         355                 360                 365            
 Asp Gln Trp Leu Glu Gln His Lys Gly Asp Phe Asn Leu Leu
     370                 375                 380        



      <210> 1566
      <211> 148
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(148)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1566
 Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys Lys Glu Asp Ala
   1               5                  10                  15    
 Leu Asn Glu Thr Arg Glu Ser Xaa Thr Lys Leu Lys Glu Leu Pro Gly
              20                  25                  30        
 Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu Cys Lys Pro Cys
          35                  40                  45            
 Leu Lys Gln Thr Cys Met Lys Ile Tyr Ala Arg Val Cys Ile Ser Gly
      50                  55                  60                
 Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu Asn Gln Ser Ser
  65                  70                  75                  80
 Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp Ser Leu Leu Glu
                  85                  90                  95    
 Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met Gln Asp His Phe
             100                 105                 110        
 Ser Arg Ala Phe Ser Ile Ile Asp Glu Leu Phe Gln Asp Arg Phe Phe
         115                 120                 125            
 Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro Phe Ser Leu Pro
     130                 135                 140                
 His Arg Arg Pro
 145            



      <210> 1567
      <211> 130
      <212> PRT
      <213> Homo sapiens


      <400> 1567
 Gly Asp Gly Gly Gly His Leu Gly Ser Gly Arg Asn Gly Gly Gly Ser
   1               5                  10                  15    
 Met Asn Ala Pro Pro Ala Phe Glu Ser Phe Leu Leu Phe Glu Gly Glu
              20                  25                  30        
 Lys Ile Thr Ile Asn Lys Asp Thr Lys Val Pro Asn Ala Cys Leu Phe
          35                  40                  45            
 Thr Met Asn Lys Glu Asp His Thr Leu Gly Asn Ile Ile Lys Ser Gln
      50                  55                  60                
 Leu Leu Lys Asp Pro Gln Val Leu Phe Ala Gly Tyr Lys Val Pro His
  65                  70                  75                  80
 Pro Leu Glu His Lys Ile Ile Ile Arg Val Gln Thr Thr Pro Asp Tyr
                  85                  90                  95    
 Ser Pro Gln Glu Ala Phe Thr Asn Ala Ile Thr Asp Leu Ile Ser Glu
             100                 105                 110        
 Leu Ser Leu Leu Glu Glu Arg Phe Arg Val Arg Ala Gly Pro Gly Gly
         115                 120                 125            
 Ala Asp
     130



      <210> 1568
      <211> 375
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(375)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1568
 Lys Arg Glu Lys Thr Gln Val Ser Asp Ala Gly Gly Ala Phe Ala Thr
   1               5                  10                  15    
 Gly Glu Xaa Pro Ile Thr Gln Trp Arg Gln Pro Thr Arg Ser Leu Pro
              20                  25                  30        
 Ile Glu Cys Met Glu Met Ser Glu Val Phe Asp Asp Ala Ser Asp Gln
          35                  40                  45            
 Asp Ser Thr Asp Lys Pro Trp Arg Pro Tyr Tyr Asn Tyr Lys Pro Lys
      50                  55                  60                
 Lys Lys Ser Arg Gln Leu Lys Lys Met Arg Lys Val Asn Trp Arg Lys
  65                  70                  75                  80
 Glu His Gly Asn Arg Ser Pro Ser His Lys Cys Lys Tyr Pro Ala Glu
                  85                  90                  95    
 Leu Asp Cys Ala Val Gly Lys Ala Pro Gln Asp Lys Pro Phe Glu Glu
             100                 105                 110        
 Glu Glu Thr Lys Glu Met Pro Lys Leu Gln Cys Glu Leu Cys Asp Gly
         115                 120                 125            
 Asp Lys Ala Val Gly Ala Gly Asn Gln Gly Arg Pro His Arg His Leu
     130                 135                 140                
 Thr Ser Arg Pro Tyr Ala Cys Glu Leu Cys Ala Lys Gln Phe Gln Ser
 145                 150                 155                 160
 Pro Ser Thr Leu Lys Met His Met Arg Cys His Thr Gly Glu Lys Pro
                 165                 170                 175    
 Tyr Gln Cys Lys Thr Cys Gly Arg Cys Phe Ser Val Gln Gly Asn Leu
             180                 185                 190        
 Gln Lys His Glu Arg Ile His Leu Gly Leu Lys Glu Phe Val Cys Gln
         195                 200                 205            
 Tyr Cys Asn Lys Ala Phe Thr Leu Asn Glu Thr Leu Lys Ile His Glu
     210                 215                 220                
 Arg Ile His Thr Gly Glu Lys Arg Tyr His Cys Gln Phe Cys Phe Gln
 225                 230                 235                 240
 Arg Phe Leu Tyr Leu Ser Thr Lys Arg Asn His Glu Gln Arg His Ile
                 245                 250                 255    
 Arg Glu His Asn Gly Lys Gly Tyr Ala Cys Phe Gln Cys Pro Lys Ile
             260                 265                 270        
 Cys Lys Thr Ala Ala Ala Leu Gly Met His Gln Lys Lys His Leu Phe
         275                 280                 285            
 Lys Ser Pro Ser Gln Gln Glu Lys Ile Gly Asp Val Cys His Glu Asn
     290                 295                 300                
 Ser Asn Pro Leu Glu Asn Gln His Ser His Trp Phe Arg Arg Gln Xaa
 305                 310                 315                 320
 Pro Lys Gly Xaa His Thr Asn Arg Cys Gly Lys Cys Cys Pro Leu Ser
                 325                 330                 335    
 Gly Lys Asn Xaa Lys Asn Leu Gln Lys Tyr Ser Trp Trp Phe Phe Xaa
             340                 345                 350        
 Leu Xaa Phe Lys Phe Ser Phe Ile Leu Ser Met Xaa Gln Ser Xaa Arg
         355                 360                 365            
 Ser Glu Ile Lys Lys Lys Lys
     370                 375



      <210> 1569
      <211> 546
      <212> PRT
      <213> Homo sapiens


      <400> 1569
 Asn Phe Met Ala Thr Ala Pro Gly Pro Ala Gly Ile Ala Met Gly Ser
   1               5                  10                  15    
 Val Gly Ser Leu Leu Glu Arg Gln Asp Phe Ser Pro Glu Glu Leu Gly
              20                  25                  30        
 Ala Ala Leu Ala Gly Ser Arg Gly Ser Arg Gln Pro Asp Gly Leu Leu
          35                  40                  45            
 Arg Lys Gly Leu Gly Gln Arg Glu Phe Leu Ser Tyr Leu His Leu Pro
      50                  55                  60                
 Lys Lys Asp Ser Lys Ser Thr Lys Asn Thr Lys Arg Ala Pro Arg Asn
  65                  70                  75                  80
 Glu Pro Ala Asp Tyr Ala Thr Leu Tyr Tyr Arg Glu His Ser Arg Ala
                  85                  90                  95    
 Gly Asp Phe Ser Lys Thr Ser Leu Pro Glu Arg Gly Arg Phe Asp Lys
             100                 105                 110        
 Cys Arg Ile Arg Pro Ser Val Phe Lys Pro Thr Ala Gly Asn Gly Lys
         115                 120                 125            
 Gly Phe Leu Ser Met Gln Ser Leu Ala Ser His Lys Gly Gln Lys Leu
     130                 135                 140                
 Trp Arg Ser Asn Gly Ser Leu His Thr Leu Ala Cys His Pro Pro Leu
 145                 150                 155                 160
 Ser Pro Gly Pro Arg Ala Ser Gln Ala Arg Ala Gln Leu Leu His Ala
                 165                 170                 175    
 Leu Ser Leu Asp Glu Gly Gly Pro Glu Pro Glu Pro Ser Leu Ser Asp
             180                 185                 190        
 Ser Ser Ser Gly Gly Ser Phe Gly Arg Ser Pro Gly Thr Gly Pro Ser
         195                 200                 205            
 Pro Phe Ser Ser Ser Leu Gly His Leu Asn His Leu Gly Gly Ser Leu
     210                 215                 220                
 Asp Arg Ala Ser Gln Gly Pro Lys Glu Ala Gly Pro Pro Ala Val Leu
 225                 230                 235                 240
 Ser Cys Leu Pro Glu Pro Pro Pro Pro Tyr Glu Phe Ser Cys Ser Ser
                 245                 250                 255    
 Ala Glu Glu Met Gly Ala Val Leu Pro Glu Thr Cys Glu Glu Leu Lys
             260                 265                 270        
 Arg Gly Leu Gly Asp Glu Asp Gly Ser Asn Pro Phe Thr Gln Val Leu
         275                 280                 285            
 Glu Glu Arg Gln Arg Leu Trp Leu Ala Glu Leu Lys Arg Leu Tyr Val
     290                 295                 300                
 Glu Arg Leu His Glu Val Thr Gln Lys Ala Glu Arg Ser Glu Arg Asn
 305                 310                 315                 320
 Leu Gln Leu Gln Leu Phe Met Ala Gln Gln Glu Gln Arg Arg Leu Arg
                 325                 330                 335    
 Lys Glu Leu Arg Ala Gln Gln Gly Leu Ala Pro Glu Pro Arg Ala Pro
             340                 345                 350        
 Gly Thr Leu Pro Glu Ala Asp Pro Ser Ala Arg Pro Glu Glu Glu Ala
         355                 360                 365            
 Arg Trp Glu Val Cys Gln Lys Thr Ala Glu Ile Ser Leu Leu Lys Gln
     370                 375                 380                
 Gln Leu Arg Glu Ala Gln Ala Glu Leu Ala His Lys Leu Ala Glu Ile
 385                 390                 395                 400
 Phe Ser Leu Lys Thr Gln Leu Arg Gly Ser Arg Ala Gln Ala Gln Ala
                 405                 410                 415    
 Gln Asp Ala Glu Leu Val Arg Leu Arg Glu Ala Val Arg Ser Leu Gln
             420                 425                 430        
 Glu Gln Ala Pro Arg Glu Glu Ala Pro Gly Ser Cys Glu Thr Asp Asp
         435                 440                 445            
 Cys Lys Ser Arg Gly Leu Leu Gly Glu Ala Gly Gly Ser Glu Ala Arg
     450                 455                 460                
 Asp Ser Ala Glu Gln Leu Arg Ala Glu Leu Leu Gln Glu Arg Leu Arg
 465                 470                 475                 480
 Gly Gln Glu Gln Ala Leu Arg Phe Glu Gln Glu Arg Arg Thr Trp Gln
                 485                 490                 495    
 Glu Glu Lys Glu Arg Val Leu Arg Tyr Gln Arg Glu Ile Gln Gly Gly
             500                 505                 510        
 Tyr Met Asp Met Tyr Arg Arg Asn Gln Ala Leu Glu Gln Glu Leu Arg
         515                 520                 525            
 Ala Leu Arg Glu Pro Pro Thr Pro Trp Ser Pro Arg Leu Glu Ser Ser
     530                 535                 540                
 Lys Ile
 545    



      <210> 1570
      <211> 313
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(313)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1570
 Asn Leu Phe Lys Thr Thr Lys Trp Gly Xaa Glu Ala Val Pro Leu Thr
   1               5                  10                  15    
 His Ile His Thr Ser Met Arg Ile Thr Cys Ser Ser Ser Glu Phe Val
              20                  25                  30        
 Gly Lys Met Leu Gly Lys Ala Val Tyr Glu Gly Ile Val Val Asp Val
          35                  40                  45            
 Pro Phe Ala Ser Phe Phe Leu Ser Gln Leu Leu Gly His His His Ser
      50                  55                  60                
 Val Phe Tyr Ser Ser Val Asp Glu Leu Pro Ser Leu Asp Ser Glu Phe
  65                  70                  75                  80
 Tyr Lys Asn Leu Thr Ser Ile Lys Arg Tyr Asp Gly Asp Ile Thr Asp
                  85                  90                  95    
 Leu Gly Leu Thr Leu Ser Tyr Asp Glu Asp Val Met Gly Gln Leu Val
             100                 105                 110        
 Cys His Glu Leu Ile Pro Gly Gly Lys Thr Ile Pro Val Thr Asn Glu
         115                 120                 125            
 Asn Lys Ile Ser Tyr Ile His Leu Met Ala His Phe Arg Met His Thr
     130                 135                 140                
 Gln Ile Lys Asn Gln Thr Ala Ala Leu Ile Ser Gly Phe Arg Ser Ile
 145                 150                 155                 160
 Ile Lys Pro Glu Trp Ile Arg Met Phe Ser Thr Pro Glu Leu Gln Arg
                 165                 170                 175    
 Leu Ile Ser Gly Asp Asn Ala Glu Ile Asp Leu Glu Asp Leu Lys Lys
             180                 185                 190        
 His Thr Val Tyr Tyr Gly Gly Phe His Gly Ser His Arg Val Ile Ile
         195                 200                 205            
 Trp Leu Trp Asp Ile Leu Ala Ser Asp Phe Thr Pro Asp Glu Arg Ala
     210                 215                 220                
 Met Phe Leu Lys Phe Val Thr Ser Cys Ser Arg Pro Pro Leu Leu Gly
 225                 230                 235                 240
 Phe Ala Tyr Leu Lys Pro Pro Phe Ser Ile Arg Cys Val Glu Val Ser
                 245                 250                 255    
 Asp Asp Gln Asp Thr Gly Asp Thr Leu Gly Ser Val Leu Arg Gly Phe
             260                 265                 270        
 Phe Thr Ile Arg Lys Arg Glu Pro Gly Gly Arg Leu Pro Thr Ser Ser
         275                 280                 285            
 Thr Cys Phe Asn Leu Leu Lys Leu Ala Gln Thr Thr Ala Arg Arg Ala
     290                 295                 300                
 Ser Ser Ala Arg Lys Leu Arg Tyr Ser
 305                 310            



      <210> 1571
      <211> 139
      <212> PRT
      <213> Homo sapiens


      <400> 1571
 Met Ser Leu Leu Gln Cys Gly Gly Ile Arg Cys Phe Lys Met Pro Glu
   1               5                  10                  15    
 Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys Lys Ala Val
              20                  25                  30        
 Thr Lys Ala Gln Lys Lys Asp Gly Lys Lys Arg Lys Arg Ser Arg Lys
          35                  40                  45            
 Glu Ser Tyr Ser Val Tyr Val Tyr Lys Val Leu Lys Gln Val His Pro
      50                  55                  60                
 Asp Thr Gly Ile Ser Ser Lys Ala Met Gly Ile Met Asn Ser Phe Val
  65                  70                  75                  80
 Asn Asp Ile Phe Glu Arg Ile Ala Gly Glu Ala Ser Arg Leu Ala His
                  85                  90                  95    
 Tyr Asn Lys Arg Ser Thr Ile Thr Ser Arg Glu Ile Gln Thr Ala Val
             100                 105                 110        
 Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala Val Ser Glu Gly
         115                 120                 125            
 Thr Lys Ala Val Thr Lys Tyr Thr Ser Ser Lys
     130                 135                



      <210> 1572
      <211> 634
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(634)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1572
 Tyr Leu Gln Arg Gln Cys Arg Leu Val Glu Pro Ile Lys Glu Met Glu
   1               5                  10                  15    
 Val Ser Leu Ser Asp Gly Ala Glu Cys His Gln Val Thr Ser Ala Ser
              20                  25                  30        
 Val Ser Ser His Thr Thr Pro Ser Gln Phe Arg Leu Lys Glu Ser Pro
          35                  40                  45            
 Ala Gly His Thr Trp Leu Ile Cys Thr Gln Glu Lys Arg Ser Val Glu
      50                  55                  60                
 Met Asp Thr Ala Ser Cys Phe His Gln Ser Thr Ser Leu Thr Thr Ala
  65                  70                  75                  80
 Ser Arg Cys Asn Thr Pro Leu Gln Phe Glu Leu Cys His Arg Lys Asp
                  85                  90                  95    
 Leu Asp Leu Ala Lys Val Gly Tyr Leu Asp Ser Asn Thr Asn Ser Cys
             100                 105                 110        
 Ala Asp Arg Pro Val Pro Thr Gln Leu Ser His Ser Asp Leu Ala Pro
         115                 120                 125            
 His Pro Ser Pro Asp Pro Leu Leu Arg Leu Val Ser Gln Ala Glu Val
     130                 135                 140                
 Glu Met Asp Ile Arg Pro Ser Xaa Glu Thr Gln Thr Arg His Phe Gly
 145                 150                 155                 160
 Gln Ser Ser Thr Xaa Cys Met Pro Thr Pro Ser Leu Asn Ala Met Pro
                 165                 170                 175    
 Arg Ala Asp Gly Leu Tyr Arg Gly Ser Pro Leu Val Gly Asp Arg Lys
             180                 185                 190        
 Pro Leu His Leu Asp Gly Gly Tyr Cys Ser Pro Ala Glu Gly Phe Ser
         195                 200                 205            
 Ser Arg Tyr Glu His Gly Leu Met Lys Asp Leu Ser Arg Gly Ser Leu
     210                 215                 220                
 Ser Pro Gly Gly Glu Arg Ala Cys Glu Gly Val Pro Ser Ala Pro Gln
 225                 230                 235                 240
 Asn Pro Pro Gln Arg Lys Lys Val Ser Leu Leu Glu Tyr Arg Lys Arg
                 245                 250                 255    
 Lys Gln Glu Ala Lys Glu Asn Ser Ala Gly Gly Gly Gly Asp Ser Ala
             260                 265                 270        
 Gln Ser Lys Ser Lys Ser Ala Gly Ala Gly Gln Gly Ser Ser Asn Ser
         275                 280                 285            
 Val Ser Asp Thr Gly Ala His Gly Val Gln Gly Ser Ser Ala Arg Thr
     290                 295                 300                
 Pro Ser Ser Pro His Lys Lys Phe Ser Pro Ser His Ser Ser Met Ser
 305                 310                 315                 320
 His Leu Glu Ala Val Ser Pro Ser Asp Ser Arg Gly Thr Ser Ser Ser
                 325                 330                 335    
 His Cys Arg Pro Gln Glu Asn Ile Ser Ser Arg Trp Met Val Pro Thr
             340                 345                 350        
 Ser Val Glu Arg Leu Arg Glu Gly Gly Ser Ile Pro Lys Val Leu Arg
         355                 360                 365            
 Ser Ser Val Arg Val Ala Gln Lys Gly Glu Pro Ser Pro Thr Trp Glu
     370                 375                 380                
 Ser Asn Ile Thr Glu Lys Asp Ser Asp Pro Ala Asp Gly Glu Gly Pro
 385                 390                 395                 400
 Glu Thr Leu Ser Ser Ala Leu Ser Lys Gly Ala Thr Val Tyr Ser Pro
                 405                 410                 415    
 Ser Arg Tyr Ser Tyr Gln Leu Leu Gln Cys Asp Ser Pro Arg Thr Glu
             420                 425                 430        
 Ser Gln Ser Leu Leu Gln Gln Ser Ser Ser Pro Phe Arg Gly His Pro
         435                 440                 445            
 Thr Gln Ser Pro Gly Tyr Ser Tyr Arg Thr Thr Ala Leu Arg Pro Gly
     450                 455                 460                
 Asn Pro Pro Ser His Gly Ser Ser Glu Ser Ser Leu Ser Ser Thr Ser
 465                 470                 475                 480
 Tyr Ser Ser Pro Ala His Pro Val Ser Thr Asp Ser Leu Ala Pro Phe
                 485                 490                 495    
 Thr Gly Thr Pro Gly Tyr Phe Ser Ser Gln Pro His Ser Gly Asn Ser
             500                 505                 510        
 Thr Gly Ser Asn Leu Pro Arg Arg Ser Cys Pro Ser Ser Ala Ala Ser
         515                 520                 525            
 Pro Thr Leu Gln Gly Pro Ser Asp Ser Pro Thr Ser Asp Ser Val Ser
     530                 535                 540                
 Gln Ser Ser Thr Gly Thr Leu Ser Ser Thr Ser Phe Pro Gln Asn Ser
 545                 550                 555                 560
 Arg Ser Ser Leu Pro Ser Asp Leu Arg Thr Ile Ser Leu Pro Ser Ala
                 565                 570                 575    
 Gly Gln Ser Ala Val Tyr Gln Ala Ser Arg Val Ser Ala Val Ser Asn
             580                 585                 590        
 Ser Gln Pro Leu Pro Thr Pro Trp Glu Trp Gly Cys Ala Pro Val Pro
         595                 600                 605            
 Thr Pro Ala Thr Ala Arg Val Arg Ser Gln Asp Ser Asp Gly Thr Phe
     610                 615                 620                
 Leu Gly Leu Leu Asp Leu Gly Lys Gln Asn
 625                 630                



      <210> 1573
      <211> 59
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(59)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1573
 Phe Ala Phe Gly Phe Glu Met Xaa Tyr Cys Ser Val Ala Gln Ala Ser
   1               5                  10                  15    
 Val Gln Trp Tyr Asp Leu Thr Leu Leu Gln Pro Pro Leu Pro Gly Val
              20                  25                  30        
 Gln Ser Asp Ser Pro Ala Ser Ser Leu Pro Asn Lys Leu Gly Leu Gln
          35                  40                  45            
 Gly Thr Ser His His Ala Trp Leu Asn Phe Leu
      50                  55                



      <210> 1574
      <211> 216
      <212> PRT
      <213> Homo sapiens


      <400> 1574
 Ala Arg Arg Gly Glu Leu Ala Gly Gly Gly Arg Ala Ser Gly Gly Arg
   1               5                  10                  15    
 Ser Gly Gly Asp Gly Gly Gly Gly Gly Gly Ala Arg Ala Pro Glu Gly
              20                  25                  30        
 Val Arg Ala Pro Ala Ala Gly Gln Pro Arg Ala Thr Lys Gly Ala Pro
          35                  40                  45            
 Pro Pro Pro Gly Thr Pro Pro Pro Ser Pro Met Ser Ser Ala Ile Glu
      50                  55                  60                
 Arg Lys Ser Leu Asp Pro Ser Glu Glu Pro Val Asp Glu Val Leu Gln
  65                  70                  75                  80
 Ile Pro Pro Ser Leu Leu Thr Cys Gly Gly Cys Gln Gln Asn Ile Gly
                  85                  90                  95    
 Asp Arg Tyr Phe Leu Lys Ala Ile Asp Gln Tyr Trp His Glu Asp Cys
             100                 105                 110        
 Leu Ser Cys Asp Leu Cys Gly Cys Arg Leu Gly Glu Val Gly Arg Arg
         115                 120                 125            
 Leu Tyr Tyr Lys Leu Gly Arg Lys Leu Cys Arg Arg Asp Tyr Leu Arg
     130                 135                 140                
 Leu Phe Gly Gln Asp Gly Leu Cys Ala Ser Cys Asp Lys Arg Ile Arg
 145                 150                 155                 160
 Ala Tyr Glu Met Thr Met Arg Val Lys Asp Lys Val Tyr His Leu Glu
                 165                 170                 175    
 Cys Phe Lys Cys Ala Ala Cys Gln Lys His Phe Cys Val Gly Asp Arg
             180                 185                 190        
 Tyr Leu Leu Ile Asn Ser Asp Ile Val Cys Glu Gln Asp Ile Tyr Glu
         195                 200                 205            
 Trp Thr Lys Ile Asn Gly Met Ile
     210                 215    



      <210> 1575
      <211> 582
      <212> PRT
      <213> Homo sapiens


      <400> 1575
 Pro Gly Arg Ala Gly Ala Gly Ser Phe Pro Phe Ser Ala Arg Arg Glu
   1               5                  10                  15    
 Gly Gly Ser Pro Ser Ala Pro Ala Ser Leu Asp Leu Val Leu Leu Pro
              20                  25                  30        
 Ala Pro Glu Glu Leu Arg Asp Val Ala Pro Leu Thr Pro Leu Leu Pro
          35                  40                  45            
 Ala Pro Val Thr Glu Arg Gly Asn Arg Ala Leu Ala His Ser Pro Glu
      50                  55                  60                
 Glu Thr Ala Pro Gly Leu Pro Thr Pro Arg Gly Glu Thr Met Ser Ser
  65                  70                  75                  80
 Val Gln Gln Gln Pro Pro Pro Pro Arg Arg Ile Thr Asn Val Glu Ser
                  85                  90                  95    
 Leu Leu Leu Thr Pro Gln Glu Asn Glu Ser Leu Phe Thr Phe Leu Gly
             100                 105                 110        
 Lys Lys Cys Val Thr Met Ser Ser Ala Val Leu Gln Leu Tyr Ala Ala
         115                 120                 125            
 Asp Arg Asn Cys Met Trp Ser Lys Lys Cys Ser Gly Val Ala Cys Leu
     130                 135                 140                
 Val Lys Asp Asn Pro Gln Arg Ser Tyr Ser Leu Arg Ile Phe Asp Ile
 145                 150                 155                 160
 Lys Asp Gly Lys Leu Leu Trp Glu Gln Glu Leu Tyr Asn Asn Phe Val
                 165                 170                 175    
 Tyr Asn Ser Pro Arg Gly Tyr Phe His Thr Phe Ala Gly Asp Thr Cys
             180                 185                 190        
 Gln Val Ala Leu Asn Phe Ala Asn Glu Glu Glu Ala Lys Lys Phe Arg
         195                 200                 205            
 Lys Ala Val Thr Asp Leu Leu Gly Arg Arg Gln Arg Lys Ser Glu Lys
     210                 215                 220                
 Arg Arg Asp Pro Pro Asn Gly Pro Asn Leu Pro Met Ala Thr Val Asp
 225                 230                 235                 240
 Ile Lys Asn Pro Glu Ile Thr Thr Asn Arg Phe Tyr Gly Pro Gln Val
                 245                 250                 255    
 Asn Asn Ile Ser His Thr Lys Glu Lys Lys Lys Gly Lys Ala Lys Lys
             260                 265                 270        
 Lys Arg Leu Thr Lys Gly Asp Ile Gly Thr Pro Ser Asn Phe Gln His
         275                 280                 285            
 Ile Gly His Val Gly Trp Asp Pro Asn Thr Gly Ser Asp Leu Asn Asn
     290                 295                 300                
 Leu Asp Pro Glu Leu Lys Asn Leu Phe Asp Met Cys Gly Ile Leu Glu
 305                 310                 315                 320
 Ala Gln Leu Lys Glu Arg Glu Thr Leu Lys Val Ile Tyr Asp Phe Ile
                 325                 330                 335    
 Glu Lys Thr Gly Gly Val Glu Ala Val Lys Asn Glu Leu Arg Arg Gln
             340                 345                 350        
 Ala Pro Pro Pro Pro Pro Pro Ser Arg Gly Gly Pro Pro Pro Pro Pro
         355                 360                 365            
 Pro Pro Pro His Ser Ser Gly Pro Pro Pro Pro Pro Ala Arg Gly Arg
     370                 375                 380                
 Gly Ala Pro Pro Pro Pro Pro Ser Arg Ala Pro Thr Ala Ala Pro Pro
 385                 390                 395                 400
 Pro Pro Pro Pro Ser Arg Pro Ser Val Glu Val Pro Pro Pro Pro Pro
                 405                 410                 415    
 Asn Arg Met Tyr Pro Pro Pro Pro Pro Ala Leu Pro Ser Ser Ala Pro
             420                 425                 430        
 Ser Gly Pro Pro Pro Pro Pro Pro Ser Val Leu Gly Val Gly Pro Val
         435                 440                 445            
 Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Pro Pro
     450                 455                 460                
 Pro Pro Gly Leu Pro Ser Asp Gly Asp His Gln Val Pro Thr Thr Ala
 465                 470                 475                 480
 Gly Asn Lys Ala Ala Leu Leu Asp Gln Ile Arg Glu Gly Ala Gln Leu
                 485                 490                 495    
 Lys Lys Val Glu Gln Asn Ser Arg Pro Val Ser Cys Ser Gly Arg Asp
             500                 505                 510        
 Ala Leu Leu Asp Gln Ile Arg Gln Gly Ile Gln Leu Lys Ser Val Ala
         515                 520                 525            
 Asp Gly Gln Glu Ser Thr Pro Pro Thr Pro Ala Pro Thr Ser Gly Ile
     530                 535                 540                
 Val Gly Ala Leu Met Glu Val Met Gln Lys Arg Ser Lys Ala Ile His
 545                 550                 555                 560
 Ser Ser Asp Glu Asp Glu Asp Glu Asp Asp Glu Glu Asp Phe Glu Asp
                 565                 570                 575    
 Asp Asp Glu Trp Glu Asp
             580        



      <210> 1576
      <211> 116
      <212> PRT
      <213> Homo sapiens


      <400> 1576
 Gly Thr Ser Gly Thr Ser Glu Glu Ala Leu Ser Lys Phe Thr Leu Lys
   1               5                  10                  15    
 Lys Val Leu Leu Leu Val Cys Phe Leu Asp Tyr Ala Lys Ile Ser Arg
              20                  25                  30        
 Leu Ile Asp His Asp Pro Cys Leu Phe Cys Lys Asp Ala Glu Phe Lys
          35                  40                  45            
 Ala Ser Lys Glu Ile Leu Leu Ala Phe Ser Arg Asp Phe Leu Ser Gly
      50                  55                  60                
 Glu Gly Asp Leu Ser Arg His Leu Gly Leu Leu Gly Leu Pro Val Asn
  65                  70                  75                  80
 His Val Gln Thr Pro Phe Asp Glu Phe Asp Phe Ala Val Thr Asn Leu
                  85                  90                  95    
 Ala Val Asp Leu Gln Cys Gly Val Arg Leu Val Arg Thr Met Glu Leu
             100                 105                 110        
 Leu Thr Gln Asn
         115    



      <210> 1577
      <211> 73
      <212> PRT
      <213> Homo sapiens


      <400> 1577
 Leu Ile Gly Phe Asp Leu Lys Lys Lys Val Leu Phe Leu Gln Ser Ile
   1               5                  10                  15    
 Phe Cys Phe Phe Glu Met Glu Ser Arg Ser Val Thr Gln Thr Gly Val
              20                  25                  30        
 Gln Trp His Asp Leu Gly Ser Leu Gln Ser Leu Pro Pro Gly Ser Ser
          35                  40                  45            
 Asp Ser Pro Ala Ser Ala Ser Gln Val Ala Gly Lys Thr Gly Leu Cys
      50                  55                  60                
 His His Thr Gly Val Val Ser Val Leu
  65                  70            



      <210> 1578
      <211> 263
      <212> PRT
      <213> Homo sapiens


      <400> 1578
 Arg Ser Gly Ser Lys Gln Ser Thr Asn Pro Ala Asp Asn Tyr His Leu
   1               5                  10                  15    
 Ala Arg Arg Arg Thr Leu Gln Val Val Val Ser Ser Leu Leu Thr Glu
              20                  25                  30        
 Ala Gly Phe Glu Ser Ala Glu Lys Ala Ser Val Glu Thr Leu Thr Glu
          35                  40                  45            
 Met Leu Gln Ser Tyr Ile Ser Glu Ile Gly Arg Ser Ala Lys Ser Tyr
      50                  55                  60                
 Cys Glu His Thr Ala Arg Thr Gln Pro Thr Leu Ser Asp Ile Val Val
  65                  70                  75                  80
 Thr Leu Val Glu Met Gly Phe Asn Val Asp Thr Leu Pro Ala Tyr Ala
                  85                  90                  95    
 Lys Arg Ser Gln Arg Met Val Ile Thr Ala Pro Pro Val Thr Asn Gln
             100                 105                 110        
 Pro Val Thr Pro Lys Ala Leu Thr Ala Gly Gln Asn Arg Pro His Pro
         115                 120                 125            
 Pro His Ile Pro Ser His Phe Pro Glu Phe Pro Asp Pro His Thr Tyr
     130                 135                 140                
 Ile Lys Thr Pro Thr Tyr Arg Glu Pro Val Ser Asp Tyr Gln Val Leu
 145                 150                 155                 160
 Arg Glu Lys Ala Ala Ser Gln Arg Arg Asp Val Glu Arg Ala Leu Thr
                 165                 170                 175    
 Arg Phe Met Ala Lys Thr Gly Glu Thr Gln Ser Leu Phe Lys Asp Asp
             180                 185                 190        
 Val Ser Thr Phe Pro Leu Ile Ala Ala Arg Pro Phe Thr Ile Pro Tyr
         195                 200                 205            
 Leu Thr Ala Leu Leu Pro Ser Glu Leu Glu Met Gln Gln Met Glu Glu
     210                 215                 220                
 Thr Asp Ser Ser Glu Gln Asp Glu Gln Thr Asp Thr Glu Asn Leu Ala
 225                 230                 235                 240
 Leu His Ile Ser Met Glu Asp Ser Gly Ala Glu Lys Glu Asn Thr Ser
                 245                 250                 255    
 Val Leu Gln Gln Asn Pro Ser
             260            



      <210> 1579
      <211> 102
      <212> PRT
      <213> Homo sapiens


      <400> 1579
 Phe Ala Phe Pro His Tyr Tyr Ile Lys Pro Tyr His Leu Lys Arg Ile
   1               5                  10                  15    
 His Arg Ala Val Leu Arg Gly Asn Leu Glu Lys Leu Lys Tyr Leu Leu
              20                  25                  30        
 Leu Thr Tyr Tyr Asp Ala Asn Lys Arg Asp Arg Lys Glu Arg Thr Ala
          35                  40                  45            
 Leu His Leu Ala Cys Ala Thr Gly Gln Pro Glu Met Val His Leu Leu
      50                  55                  60                
 Val Ser Arg Arg Cys Glu Leu Asn Leu Cys Asp Arg Glu Asp Arg Thr
  65                  70                  75                  80
 Pro Leu Ile Lys Ala Val Gln Leu Arg Gln Glu Ala Cys Ala Thr Leu
                  85                  90                  95    
 Leu Leu Gln Asn Gly Ala
             100        



      <210> 1580
      <211> 138
      <212> PRT
      <213> Homo sapiens


      <400> 1580
 Gly Arg Leu Trp Gly Cys Val Ser Lys Lys Ser Val Gly Cys Leu Pro
   1               5                  10                  15    
 His Pro Gly Cys Leu Trp Ala Ala Phe Leu Thr Leu Asp Ala Cys Gly
              20                  25                  30        
 Leu Pro Ser Ser Pro Trp Met Pro Val Gly Ser Leu Pro His Pro Gly
          35                  40                  45            
 Cys Leu Trp Ala Ala Phe Leu Thr Leu Asp Ala Cys Gly Leu Pro Ser
      50                  55                  60                
 Ser Pro Trp Met Pro Val Thr Trp Phe Pro Trp Gly Leu Pro Lys Leu
  65                  70                  75                  80
 Arg Asp Pro Lys Pro Pro Ser Asn Leu Met Thr Arg Pro Val Ser Glu
                  85                  90                  95    
 Pro Pro Val Leu Ser Pro Ser Pro Ser Pro Thr Pro Ser Ala Thr Arg
             100                 105                 110        
 Pro Thr His Phe Pro Ser Leu Lys Gly Pro Ala His Arg Pro Ala His
         115                 120                 125            
 Val Phe Pro Phe Asn Pro Cys Phe Val Pro
     130                 135            



      <210> 1581
      <211> 162
      <212> PRT
      <213> Homo sapiens


      <400> 1581
 Val Thr Ser Leu Arg Gln Ala Trp Gly Arg Glu Leu Leu Gln Phe Asp
   1               5                  10                  15    
 His Gly Gln Ser Asn Pro Thr Tyr Tyr Ile Arg Leu Ala Asn Arg Asp
              20                  25                  30        
 Leu Val Leu Arg Lys Lys Pro Pro Gly Thr Leu Leu Pro Ser Ala His
          35                  40                  45            
 Ala Ile Glu Arg Glu Phe Arg Ile Met Lys Ala Leu Ala Asn Ala Gly
      50                  55                  60                
 Val Pro Val Pro Asn Val Leu Asp Leu Cys Glu Asp Ser Ser Val Ile
  65                  70                  75                  80
 Gly Thr Pro Phe Tyr Val Met Glu Tyr Cys Pro Gly Leu Ile Tyr Lys
                  85                  90                  95    
 Asp Pro Ser Leu Pro Gly Leu Glu Pro Ser His Arg Arg Ala Ile Tyr
             100                 105                 110        
 Thr Ala Met Asn Thr Val Leu Cys Lys Ile His Ser Val Asp Leu Gln
         115                 120                 125            
 Ala Val Gly Leu Glu Asp Tyr Gly Lys Gln Gly Ser Thr Thr Trp Val
     130                 135                 140                
 Phe His Pro Glu Glu Pro Glu Val Leu Cys Cys Ser Leu Thr Gly Asn
 145                 150                 155                 160
 Phe Leu
        



      <210> 1582
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 1582
 Glu Phe Leu Lys Phe Cys Cys Leu Ile Ala Ala Ile Met Gly Arg Met
   1               5                  10                  15    
 His Ala Pro Gly Lys Gly Leu Ser Gln Ser Ala Leu Pro Tyr Arg Arg
              20                  25                  30        
 Ser Val Pro Thr Trp Leu Lys Leu Thr Ser Asp Asp Val Lys Glu Gln
          35                  40                  45            
 Ile Tyr Lys Leu Ala Lys Lys Gly Leu Thr Pro Ser Gln Ile Gly Val
      50                  55                  60                
 Ile Leu Arg Asp Ser His Gly Val Ala Gln Val Arg Phe Val Thr Gly
  65                  70                  75                  80
 Asn Lys Ile Leu Arg Ile Leu Lys Ser Lys Gly Leu Ala Pro Asp Leu
                  85                  90                  95    
 Pro Glu Asp Leu Tyr His Leu Ile Lys Lys Ala Val Ala Val Arg Lys
             100                 105                 110        
 His Leu Glu Arg Asn Arg Lys Asp Lys Asp Ala Lys Phe Arg Leu Ile
         115                 120                 125            
 Leu Ile Glu Ser Arg Ile His Arg Leu Ala Arg Tyr Tyr Lys Thr Lys
     130                 135                 140                
 Arg Val Leu Pro Pro Asn Trp Lys Tyr Glu Ser Ser Thr Ala Ser Ala
 145                 150                 155                 160
 Leu Val Ala
            



      <210> 1583
      <211> 316
      <212> PRT
      <213> Homo sapiens


      <400> 1583
 Arg Ser His Ala Ser Arg Leu Pro Glu Leu Pro Ser Gly Cys Leu Val
   1               5                  10                  15    
 Leu Gln Val Gln Glu Leu Val Gln Met Ser Gly Met Glu Ala Thr Val
              20                  25                  30        
 Thr Ile Pro Ile Trp Gln Asn Lys Pro His Gly Ala Ala Arg Ser Val
          35                  40                  45            
 Val Arg Arg Ile Gly Thr Asn Leu Pro Leu Lys Pro Cys Ala Arg Ala
      50                  55                  60                
 Ser Phe Glu Thr Leu Pro Asn Ile Ser Asp Leu Cys Leu Arg Asp Val
  65                  70                  75                  80
 Pro Pro Val Pro Thr Leu Ala Asp Ile Ala Trp Ile Ala Ala Asp Glu
                  85                  90                  95    
 Glu Glu Thr Tyr Ala Arg Val Arg Ser Asp Thr Arg Pro Leu Arg His
             100                 105                 110        
 Thr Trp Lys Pro Ser Pro Leu Ile Val Met Gln Arg Asn Ala Ser Val
         115                 120                 125            
 Pro Asn Leu Arg Gly Ser Glu Glu Arg Leu Leu Ala Leu Lys Lys Pro
     130                 135                 140                
 Ala Leu Pro Ala Leu Ser Arg Thr Thr Glu Leu Gln Asp Glu Leu Ser
 145                 150                 155                 160
 His Leu Arg Ser Gln Ile Ala Lys Ile Val Ala Ala Asp Ala Ala Ser
                 165                 170                 175    
 Ala Ser Leu Thr Pro Asp Phe Leu Ser Pro Gly Ser Ser Asn Val Ser
             180                 185                 190        
 Ser Pro Leu Pro Cys Phe Gly Ser Ser Phe His Ser Thr Thr Ser Phe
         195                 200                 205            
 Val Ile Ser Asp Ile Thr Glu Glu Thr Glu Val Glu Val Pro Glu Leu
     210                 215                 220                
 Pro Ser Val Pro Leu Leu Cys Ser Ala Ser Pro Glu Cys Cys Lys Pro
 225                 230                 235                 240
 Glu His Lys Ala Ala Cys Ser Ser Ser Glu Glu Asp Asp Cys Val Ser
                 245                 250                 255    
 Leu Ser Lys Ala Ser Ser Phe Ala Asp Met Met Gly Ile Leu Lys Asp
             260                 265                 270        
 Phe His Arg Met Lys Gln Ser Gln Asp Leu Asn Arg Ser Leu Leu Lys
         275                 280                 285            
 Glu Glu Asp Pro Ala Val Leu Ile Ser Glu Val Leu Arg Arg Lys Phe
     290                 295                 300                
 Ala Leu Lys Glu Glu Asp Ile Ser Arg Lys Gly Asn
 305                 310                 315    



      <210> 1584
      <211> 62
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(62)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1584
 Asp Gly Gln Gln Leu Ile Ala Leu His Arg Leu Ala Leu Arg Glu Leu
   1               5                  10                  15    
 Gln Gln Ala Val His Ala Gly Ile Ala Pro Ala Gly Glu Asn Pro Val
              20                  25                  30        
 Xaa Trp Trp Phe Arg Asn Arg Gln Asn Pro Leu Ile Ala Leu Arg Ser
          35                  40                  45            
 Leu Pro Ala Phe Gln Ser Gly Asn Leu Ser Cys Gln Leu His
      50                  55                  60        



      <210> 1585
      <211> 228
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(228)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1585
 Leu Arg Lys Asn Gln Glu Phe Gly Val Thr Met Gly Lys Gln Lys Lys
   1               5                  10                  15    
 Thr Arg Lys Tyr Ala Thr Met Lys Arg Met Leu Ser Leu Arg Asp Gln
              20                  25                  30        
 Arg Leu Lys Glu Lys Asp Arg Leu Lys Pro Lys Lys Lys Glu Lys Lys
          35                  40                  45            
 Asp Pro Ser Ala Leu Lys Glu Arg Glu Val Pro Gln His Pro Ser Cys
      50                  55                  60                
 Leu Phe Phe Gln Tyr Asn Thr Gln Leu Gly Pro Pro Tyr His Ile Leu
  65                  70                  75                  80
 Val Asp Thr Asn Phe Ile Asn Phe Ser Ile Lys Ala Lys Leu Asp Leu
                  85                  90                  95    
 Val Gln Ser Met Met Asp Cys Leu Tyr Ala Lys Cys Ile Pro Cys Ile
             100                 105                 110        
 Thr Asp Cys Val Met Ala Glu Ile Glu Lys Leu Gly Gln Lys Tyr Arg
         115                 120                 125            
 Val Ala Leu Arg Ile Ala Lys Asp Pro Arg Phe Glu Arg Leu Pro Cys
     130                 135                 140                
 Thr His Lys Gly Thr Tyr Ala Asp Asp Cys Leu Val Gln Arg Val Thr
 145                 150                 155                 160
 Arg His Lys Cys Tyr Ile Val Ala Thr Val Asp Arg Asp Leu Lys Arg
                 165                 170                 175    
 Arg Ile Arg Lys Ile Pro Gly Val Pro Ile Met Tyr Ile Ser Asn His
             180                 185                 190        
 Arg Xaa Glu Ile Glu Lys Leu Gly Gln Lys Tyr Arg Val Ala Leu Arg
         195                 200                 205            
 Ile Ala Lys Asp Pro Arg Phe Glu Arg Leu Pro Cys Thr His Lys Gly
     210                 215                 220                
 Asn Leu Cys Arg
 225            



      <210> 1586
      <211> 55
      <212> PRT
      <213> Homo sapiens


      <400> 1586
 Arg Thr Arg Gly Leu Tyr Pro Ala Phe Ala Gln Pro Gly Gln Glu Cys
   1               5                  10                  15    
 Tyr Leu Gln Lys Glu Pro Leu Leu Phe Ser Cys Ala Gly Ser Asn Thr
              20                  25                  30        
 Lys Tyr Arg Arg Leu Cys Pro Cys Arg Asp Phe Arg Lys Gly Gln Val
          35                  40                  45            
 Ala Leu Cys Gln Gly Cys Leu
      50                  55



      <210> 1587
      <211> 105
      <212> PRT
      <213> Homo sapiens


      <400> 1587
 Phe Val Asp Ser Pro Arg Phe Arg Ala Thr Ile Asp Glu Val Glu Thr
   1               5                  10                  15    
 Asp Val Val Glu Ile Glu Ala Lys Leu Asp Lys Leu Val Lys Leu Cys
              20                  25                  30        
 Ser Gly Met Val Glu Ala Gly Lys Ala Tyr Val Ser Thr Ser Arg Leu
          35                  40                  45            
 Phe Val Ser Gly Val Arg Asp Leu Ser Gln Gln Cys Gln Gly Asp Thr
      50                  55                  60                
 Val Ile Ser Glu Cys Leu Gln Arg Phe Ala Asp Ser Leu Gln Glu Val
  65                  70                  75                  80
 Val Asn Tyr His Met Ile Leu Phe Asp Gln Ala Gln Arg Ser Val Arg
                  85                  90                  95    
 Gln Gln Leu Gln Ser Phe Val Lys Glu
             100                 105



      <210> 1588
      <211> 83
      <212> PRT
      <213> Homo sapiens


      <400> 1588
 Ser Ala Phe Ser Tyr Ile Pro Pro Arg Arg Leu Asp Pro Thr Glu His
   1               5                  10                  15    
 Ser Tyr Tyr Tyr Arg Pro Ala Arg Glu Gln Glu Arg Pro Ala Gly Val
              20                  25                  30        
 Leu Thr Ser Ser Val Tyr Gly Lys Arg Ile Asn Gln Pro Ile Glu Pro
          35                  40                  45            
 Leu Asn Arg Asp Phe Gly Arg Ala Asn His Val Gln Ala Asp Phe Tyr
      50                  55                  60                
 Arg Lys Asn Asp Ile Pro Ser Leu Lys Glu Pro Gly Phe Gly His Ile
  65                  70                  75                  80
 Ala Pro Ser
            



      <210> 1589
      <211> 111
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(111)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1589
 Ile Ala Thr Glu Leu Phe Leu Leu Cys Lys Lys Thr Lys Thr Leu Cys
   1               5                  10                  15    
 Arg Tyr Phe Ser Tyr Lys Leu Met Xaa Asn Thr Asp Phe Phe Lys Gly
              20                  25                  30        
 Arg Arg Glu Gln Tyr Leu Val Gln Leu Leu Cys Asn Leu Ile Ser Lys
          35                  40                  45            
 Cys Phe Xaa Asn Asp Thr Thr Gly Glu His Ile Met Glu Asp Leu Asp
      50                  55                  60                
 Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile Met Leu Met
  65                  70                  75                  80
 Ala Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu Gly Asp Glu
                  85                  90                  95    
 Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly Thr Pro
             100                 105                 110    



      <210> 1590
      <211> 111
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(111)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1590
 Ile Ala Thr Glu Leu Phe Leu Leu Cys Lys Lys Thr Lys Thr Leu Cys
   1               5                  10                  15    
 Arg Tyr Phe Ser Tyr Lys Leu Met Xaa Asn Thr Asp Phe Phe Lys Gly
              20                  25                  30        
 Arg Arg Glu Gln Tyr Leu Val Gln Leu Leu Cys Asn Leu Ile Ser Lys
          35                  40                  45            
 Cys Phe Xaa Asn Asp Thr Thr Gly Glu His Ile Met Glu Asp Leu Asp
      50                  55                  60                
 Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile Met Leu Met
  65                  70                  75                  80
 Ala Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu Gly Asp Glu
                  85                  90                  95    
 Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly Thr Pro
             100                 105                 110    



      <210> 1591
      <211> 111
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(111)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1591
 Ile Ala Thr Glu Leu Phe Leu Leu Cys Lys Lys Thr Lys Thr Leu Cys
   1               5                  10                  15    
 Arg Tyr Phe Ser Tyr Lys Leu Met Xaa Asn Thr Asp Phe Phe Lys Gly
              20                  25                  30        
 Arg Arg Glu Gln Tyr Leu Val Gln Leu Leu Cys Asn Leu Ile Ser Lys
          35                  40                  45            
 Cys Phe Xaa Asn Asp Thr Thr Gly Glu His Ile Met Glu Asp Leu Asp
      50                  55                  60                
 Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile Met Leu Met
  65                  70                  75                  80
 Ala Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu Gly Asp Glu
                  85                  90                  95    
 Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly Thr Pro
             100                 105                 110    



      <210> 1592
      <211> 150
      <212> PRT
      <213> Homo sapiens


      <400> 1592
 Ser Ser Arg Gly Cys Gly Arg Gly Leu Gln Ala Cys Leu Gly Leu Gly
   1               5                  10                  15    
 Ala Ala Gly Pro Gly His Pro Gly Ala Gly Pro Val Cys Pro Leu Asp
              20                  25                  30        
 Gly Pro Ser Ser Ser Pro Asp Tyr Tyr Phe Val Thr Arg Glu Val Met
          35                  40                  45            
 Gln Arg Asp Ile Ala Ala Gly Asp Phe Ile Glu His Ala Glu Phe Ser
      50                  55                  60                
 Gly Asn Leu Tyr Gly Thr Ser Lys Val Ala Val Gln Ala Val Gln Ala
  65                  70                  75                  80
 Met Asn Arg Ile Cys Val Leu Asp Val Asp Leu Gln Gly Val Arg Asn
                  85                  90                  95    
 Ile Lys Ala Thr Asp Leu Arg Pro Ile Tyr Ile Ser Val Gln Pro Pro
             100                 105                 110        
 Ser Leu His Val Leu Glu Gln Arg Leu Arg Gln Arg Asn Thr Glu Thr
         115                 120                 125            
 Glu Glu Ser Leu Met Lys Arg Leu Ala Ala Ala Gln Ala Asp Met Glu
     130                 135                 140                
 Ser Ser Lys Glu Pro Arg
 145                 150



      <210> 1593
      <211> 149
      <212> PRT
      <213> Homo sapiens


      <400> 1593
 Gln Thr Gln Arg Glu Pro Thr Met Val Leu Ser Pro Ala Asp Lys Thr
   1               5                  10                  15    
 Asn Val Lys Ala Ala Trp Gly Lys Val Gly Ala His Ala Gly Glu Tyr
              20                  25                  30        
 Gly Ala Glu Ala Leu Glu Arg Met Phe Leu Ser Phe Pro Thr Thr Lys
          35                  40                  45            
 Thr Tyr Phe Pro His Phe Asp Leu Ser His Gly Ser Ala Gln Val Lys
      50                  55                  60                
 Gly His Gly Lys Lys Val Ala Asp Ala Leu Thr Asn Ala Val Ala His
  65                  70                  75                  80
 Val Asp Asp Met Pro Asn Ala Leu Ser Ala Leu Ser Asp Leu His Ala
                  85                  90                  95    
 His Lys Leu Arg Val Asp Pro Val Asn Phe Lys Leu Leu Ser His Cys
             100                 105                 110        
 Leu Leu Val Thr Leu Ala Ala His Leu Pro Ala Glu Phe Thr Pro Ala
         115                 120                 125            
 Val His Ala Ser Leu Asp Lys Phe Leu Ala Ser Val Ser Thr Val Leu
     130                 135                 140                
 Thr Ser Lys Tyr Arg
 145                



      <210> 1594
      <211> 140
      <212> PRT
      <213> Homo sapiens


      <400> 1594
 Glu Leu Gln Asp Cys Phe Asp Val His Asp Ala Ser Trp Glu Glu Gln
   1               5                  10                  15    
 Ile Phe Trp Gly Trp His Asn Asp Val His Ile Phe Asp Thr Lys Thr
              20                  25                  30        
 Gln Thr Trp Phe Gln Pro Glu Ile Lys Gly Gly Val Pro Pro Gln Pro
          35                  40                  45            
 Arg Ala Ala His Thr Cys Ala Val Leu Gly Asn Lys Gly Tyr Ile Phe
      50                  55                  60                
 Gly Gly Arg Val Leu Gln Thr Arg Met Asn Asp Leu His Tyr Leu Asn
  65                  70                  75                  80
 Leu Asp Thr Trp Thr Trp Ser Gly Arg Ile Thr Ile Asn Gly Glu Ser
                  85                  90                  95    
 Pro Lys His Arg Ser Trp His Thr Leu Thr Pro Ile Ala Asp Asp Lys
             100                 105                 110        
 Leu Phe Leu Cys Gly Gly Leu Asn Ala Tyr Asn Met Pro Leu Ser Asp
         115                 120                 125            
 Gly Trp Ile His Asn Val Thr Thr His Cys Trp Lys
     130                 135                 140



      <210> 1595
      <211> 792
      <212> PRT
      <213> Homo sapiens


      <400> 1595
 Ser Leu Gln Leu Pro Gln Ser Ala Val Trp Ser Val Pro Ser Ser Val
   1               5                  10                  15    
 Met Asn Pro Glu Glu Gln Ile Val Thr Trp Leu Ile Ser Leu Gly Val
              20                  25                  30        
 Leu Glu Ser Pro Lys Lys Thr Ile Cys Asp Pro Glu Glu Phe Leu Lys
          35                  40                  45            
 Ser Ser Leu Lys Asn Gly Val Val Leu Cys Lys Leu Ile Asn Arg Leu
      50                  55                  60                
 Met Pro Gly Ser Val Glu Lys Phe Cys Leu Asp Pro Gln Thr Glu Ala
  65                  70                  75                  80
 Asp Cys Ile Asn Asn Ile Asn Asp Phe Leu Lys Gly Cys Ala Thr Leu
                  85                  90                  95    
 Gln Val Glu Ile Phe Asp Pro Asp Asp Leu Tyr Ser Gly Val Asn Phe
             100                 105                 110        
 Ser Lys Val Leu Ser Thr Leu Leu Ala Val Asn Lys Ala Thr Glu Asp
         115                 120                 125            
 Gln Leu Ser Glu Arg Pro Cys Gly Arg Ser Ser Ser Leu Ser Ala Ala
     130                 135                 140                
 Asn Thr Ser Gln Thr Asn Pro Gln Gly Ala Val Ser Ser Thr Val Ser
 145                 150                 155                 160
 Gly Leu Gln Arg Gln Ser Lys Thr Val Glu Met Thr Glu Asn Gly Ser
                 165                 170                 175    
 His Gln Leu Ile Val Lys Ala Arg Phe Asn Phe Lys Gln Thr Asn Glu
             180                 185                 190        
 Asp Glu Leu Ser Val Cys Lys Gly Asp Ile Ile Tyr Val Thr Arg Val
         195                 200                 205            
 Glu Glu Gly Gly Trp Trp Glu Gly Thr Leu Asn Gly Arg Thr Gly Trp
     210                 215                 220                
 Phe Pro Ser Asn Tyr Val Arg Glu Ile Lys Ser Ser Glu Arg Pro Leu
 225                 230                 235                 240
 Ser Pro Lys Ala Val Lys Gly Phe Glu Thr Ala Pro Leu Thr Lys Asn
                 245                 250                 255    
 Tyr Tyr Thr Val Val Leu Gln Asn Ile Leu Asp Thr Glu Lys Glu Tyr
             260                 265                 270        
 Ala Lys Glu Leu Gln Ser Leu Leu Val Thr Tyr Leu Arg Pro Leu Gln
         275                 280                 285            
 Ser Asn Asn Asn Leu Ser Thr Val Glu Val Thr Ser Leu Leu Gly Asn
     290                 295                 300                
 Phe Glu Glu Val Cys Thr Phe Gln Gln Thr Leu Cys Gln Ala Leu Glu
 305                 310                 315                 320
 Glu Cys Ser Lys Phe Pro Glu Asn Gln His Lys Val Gly Gly Cys Leu
                 325                 330                 335    
 Leu Ser Leu Met Pro His Phe Lys Ser Met Tyr Leu Ala Tyr Cys Ala
             340                 345                 350        
 Asn His Pro Ser Ala Val Asn Val Leu Thr Gln His Ser Asp Glu Leu
         355                 360                 365            
 Glu Gln Phe Met Glu Asn Gln Gly Ala Ser Ser Pro Gly Ile Leu Ile
     370                 375                 380                
 Leu Thr Thr Asn Leu Ser Lys Pro Phe Met Arg Leu Glu Lys Tyr Val
 385                 390                 395                 400
 Thr Leu Leu Gln Glu Leu Glu Arg His Met Glu Asp Thr His Pro Asp
                 405                 410                 415    
 His Gln Asp Ile Leu Lys Ala Ile Val Ala Phe Lys Thr Leu Met Gly
             420                 425                 430        
 Gln Cys Gln Asp Leu Arg Lys Arg Lys Gln Leu Glu Leu Gln Ile Leu
         435                 440                 445            
 Ser Glu Pro Ile Gln Ala Trp Glu Gly Glu Asp Ile Lys Asn Leu Gly
     450                 455                 460                
 Asn Val Ile Phe Met Ser Gln Val Met Val Gln Tyr Gly Ala Cys Glu
 465                 470                 475                 480
 Glu Lys Glu Glu Arg Tyr Leu Met Leu Phe Ser Asn Val Leu Ile Met
                 485                 490                 495    
 Leu Ser Ala Ser Pro Arg Met Ser Gly Phe Ile Tyr Gln Gly Lys Ile
             500                 505                 510        
 Pro Ile Ala Gly Thr Val Val Thr Arg Leu Asp Glu Ile Glu Gly Asn
         515                 520                 525            
 Asp Cys Thr Phe Glu Ile Thr Gly Asn Thr Val Glu Arg Ile Val Val
     530                 535                 540                
 His Cys Asn Asn Asn Gln Asp Phe Gln Glu Trp Leu Glu Gln Leu Asn
 545                 550                 555                 560
 Arg Leu Ile Arg Gly Pro Ala Ser Cys Ser Ser Leu Ser Lys Thr Ser
                 565                 570                 575    
 Ser Ser Ser Cys Ser Ala His Ser Ser Phe Ser Ser Thr Gly Gln Pro
             580                 585                 590        
 Arg Gly Pro Leu Glu Pro Pro Gln Ile Ile Lys Pro Trp Ser Leu Ser
         595                 600                 605            
 Cys Leu Arg Pro Ala Pro Pro Leu Arg Pro Ser Ala Ala Leu Gly Tyr
     610                 615                 620                
 Lys Glu Arg Met Ser Tyr Ile Leu Lys Glu Ser Ser Lys Ser Pro Lys
 625                 630                 635                 640
 Thr Met Lys Lys Phe Leu His Lys Arg Lys Thr Glu Arg Lys Pro Ser
                 645                 650                 655    
 Glu Glu Glu Tyr Val Ile Arg Lys Ser Thr Ala Ala Leu Glu Glu Asp
             660                 665                 670        
 Ala Gln Ile Leu Lys Val Ile Glu Ala Tyr Cys Thr Ser Ala Asn Phe
         675                 680                 685            
 Gln Gln Gly His Gly Ser Ser Thr Arg Lys Asp Ser Ile Pro Gln Val
     690                 695                 700                
 Leu Leu Pro Glu Glu Glu Lys Leu Ile Ile Glu Glu Thr Arg Ser Asn
 705                 710                 715                 720
 Gly Gln Thr Ile Met Glu Glu Lys Ser Leu Val Asp Thr Val Tyr Ala
                 725                 730                 735    
 Leu Lys Asp Glu Val Arg Glu Leu Lys Gln Glu Asn Lys Arg Met Lys
             740                 745                 750        
 Gln Cys Leu Glu Glu Glu Leu Lys Ser Arg Arg Asp Leu Glu Lys Leu
         755                 760                 765            
 Val Arg Arg Leu Leu Lys Gln Thr Asp Glu Cys Ile Arg Gly Glu Ser
     770                 775                 780                
 Ser Ser Lys Thr Ser Ile Leu Pro
 785                 790        



      <210> 1596
      <211> 131
      <212> PRT
      <213> Homo sapiens


      <400> 1596
 Met Arg Asp Lys Gly Ser Gln Glu Arg Leu Gln Leu Asp Pro Gly Gln
   1               5                  10                  15    
 Lys Leu Val Val Ser Met Asp Lys Ala Gly Gly Phe Ser Leu Glu Lys
              20                  25                  30        
 Glu Val Ala Gly Leu Trp Ile Lys Ile Pro Cys Thr Asp Thr Leu Ala
          35                  40                  45            
 Ala Val Pro Leu Asn Thr Ser Val Met Cys Leu Thr Cys Tyr Ser Tyr
      50                  55                  60                
 Trp Gly Ala Leu Pro Arg Ala Pro Ala Tyr Leu Trp Ala Ser Cys His
  65                  70                  75                  80
 Cys Pro Phe Lys Glu Ile Cys Pro Ile Asn Thr Arg Val Arg Gln Thr
                  85                  90                  95    
 Lys Ala Glu Arg Thr Asp Arg Ser Thr Asn Ser Ala Gln Leu Ser Asp
             100                 105                 110        
 Thr Trp Glu Met Ala Asn Gly Met Met Ile Ser Ala Gly Thr Trp Asn
         115                 120                 125            
 Trp Arg Ala
     130    



      <210> 1597
      <211> 131
      <212> PRT
      <213> Homo sapiens


      <400> 1597
 Met Arg Asp Lys Gly Ser Gln Glu Arg Leu Gln Leu Asp Pro Gly Gln
   1               5                  10                  15    
 Lys Leu Val Val Ser Met Asp Lys Ala Gly Gly Phe Ser Leu Glu Lys
              20                  25                  30        
 Glu Val Ala Gly Leu Trp Ile Lys Ile Pro Cys Thr Asp Thr Leu Ala
          35                  40                  45            
 Ala Val Pro Leu Asn Thr Ser Val Met Cys Leu Thr Cys Tyr Ser Tyr
      50                  55                  60                
 Trp Gly Ala Leu Pro Arg Ala Pro Ala Tyr Leu Trp Ala Ser Cys His
  65                  70                  75                  80
 Cys Pro Phe Lys Glu Ile Cys Pro Ile Asn Thr Arg Val Arg Gln Thr
                  85                  90                  95    
 Lys Ala Glu Arg Thr Asp Arg Ser Thr Asn Ser Ala Gln Leu Ser Asp
             100                 105                 110        
 Thr Trp Glu Met Ala Asn Gly Met Met Ile Ser Ala Gly Thr Trp Asn
         115                 120                 125            
 Trp Arg Ala
     130    



      <210> 1598
      <211> 85
      <212> PRT
      <213> Homo sapiens


      <400> 1598
 Met Ala His Tyr Lys Ala Ala Asn Leu Lys Arg Glu Gln Phe Arg Arg
   1               5                  10                  15    
 Tyr Leu Glu Lys Ser Gly Val Leu Asp Thr Leu Thr Lys Val Leu His
              20                  25                  30        
 His Leu Gly Thr Ala Thr Pro Glu Asn Pro Glu Ile Glu Leu Leu Cys
          35                  40                  45            
 Leu Glu Leu Ala Lys Thr Lys Glu Lys Tyr Lys Ala Ile Val Glu Lys
      50                  55                  60                
 Asn Lys Lys Leu Lys Ala Lys Leu Ala Gln Tyr Glu Pro Pro Gln Glu
  65                  70                  75                  80
 Glu Lys Tyr Ala Glu
                  85



      <210> 1599
      <211> 85
      <212> PRT
      <213> Homo sapiens


      <400> 1599
 Met Ala His Tyr Lys Ala Ala Asn Leu Lys Arg Glu Gln Phe Arg Arg
   1               5                  10                  15    
 Tyr Leu Glu Lys Ser Gly Val Leu Asp Thr Leu Thr Lys Val Leu His
              20                  25                  30        
 His Leu Gly Thr Ala Thr Pro Glu Asn Pro Glu Ile Glu Leu Leu Cys
          35                  40                  45            
 Leu Glu Leu Ala Lys Thr Lys Glu Lys Tyr Lys Ala Ile Val Glu Lys
      50                  55                  60                
 Asn Lys Lys Leu Lys Ala Lys Leu Ala Gln Tyr Glu Pro Pro Gln Glu
  65                  70                  75                  80
 Glu Lys Tyr Ala Glu
                  85



      <210> 1600
      <211> 461
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(461)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1600
 Ala Ala Ala Glu Arg Glu Leu Glu Leu Leu Arg Ala Ser Leu Glu His
   1               5                  10                  15    
 Gln Arg Gly Val Ser Glu Leu Leu Arg Gly Arg Leu Arg Glu Leu Glu
              20                  25                  30        
 Glu Ala Arg Glu Ala Ala Glu Glu Ala Ala Ala Gly Ala Arg Ala Gln
          35                  40                  45            
 Leu Arg Glu Ala Thr Thr Gln Thr Pro Trp Ser Cys Ala Glu Lys Ala
      50                  55                  60                
 Ala Gln Thr Glu Ser Pro Ala Glu Gly Pro Pro Xaa Leu Arg Arg Ala
  65                  70                  75                  80
 Arg Pro Asp Pro Trp Thr Glu Thr Arg Ala Val Ala Pro Ala Gly Ile
                  85                  90                  95    
 Leu Lys Ser Ile Met Lys Lys Arg Asp Gly Thr Pro Gly Ala Gln Pro
             100                 105                 110        
 Ser Ser Gly Pro Lys Ser Leu Gln Phe Val Gly Val Leu Asn Gly Glu
         115                 120                 125            
 Tyr Glu Ser Ser Ser Ser Glu Asp Thr Asn Asp Ser Asp Gly Asp Ser
     130                 135                 140                
 Glu Asn Gly Gly Ala Glu Pro Pro Gly Ser Ser Ser Gly Ser Gly Asp
 145                 150                 155                 160
 Asp Ser Gly Gly Gly Ser Asp Ser Gly Thr Pro Gly Pro Pro Ser Gly
                 165                 170                 175    
 Gly Asp Ile Arg Asp Pro Glu Pro Glu Ala Glu Ala Glu Pro Gln Gln
             180                 185                 190        
 Val Ala Gln Gly Arg Cys Glu Leu Ser Pro Arg Leu Arg Glu Ala Cys
         195                 200                 205            
 Val Ala Leu Gln Arg Gln Leu Ser Arg Pro Arg Gly Val Ala Ser Asp
     210                 215                 220                
 Gly Gly Ala Val Arg Leu Val Ala Gln Glu Trp Phe Arg Val Ser Ser
 225                 230                 235                 240
 Gln Arg Arg Ser Gln Ala Glu Pro Val Ala Arg Met Leu Glu Gly Val
                 245                 250                 255    
 Arg Arg Leu Gly Pro Glu Leu Leu Ala His Val Val Asn Leu Ala Asp
             260                 265                 270        
 Gly Asn Gly Asn Thr Ala Leu His Tyr Ser Val Ser His Gly Asn Leu
         275                 280                 285            
 Ala Ile Ala Ser Leu Leu Leu Asp Thr Gly Ala Cys Glu Val Asn Arg
     290                 295                 300                
 Gln Asn Arg Ala Gly Tyr Ser Ala Leu Met Leu Ala Ala Leu Thr Ser
 305                 310                 315                 320
 Val Arg Gln Glu Glu Glu Asp Met Ala Val Val Gln Arg Leu Phe Cys
                 325                 330                 335    
 Met Gly Asp Val Asn Ala Lys Ala Ser Gln Thr Gly Gln Thr Ala Leu
             340                 345                 350        
 Met Leu Ala Ile Ser His Gly Arg Gln Asp Met Val Ala Thr Leu Leu
         355                 360                 365            
 Ala Cys Gly Ala Asp Val Asn Ala Gln Asp Ala Asp Gly Ala Thr Ala
     370                 375                 380                
 Leu Met Cys Ala Ser Glu Tyr Gly Arg Leu Asp Thr Val Arg Leu Leu
 385                 390                 395                 400
 Leu Thr Gln Pro Gly Cys Asp Pro Ser Ile Leu Asp Asn Glu Gly Thr
                 405                 410                 415    
 Ser Ala Leu Ala Ile Ala Leu Glu Ala Glu Thr Gly Met Lys Val Ala
             420                 425                 430        
 Ala Leu Leu His Ala His Leu Ser Ser Gly His Pro Asp Thr Gln Ser
         435                 440                 445            
 Gly Val Thr Pro Leu Ala Pro Gln Thr Ala Asn Thr Trp
     450                 455                 460    



      <210> 1601
      <211> 75
      <212> PRT
      <213> Homo sapiens


      <400> 1601
 Asn Pro Glu Asn Asn Arg Ser Phe Phe Gly Trp Phe Ser Asn His Ser
   1               5                  10                  15    
 Ser Ile Glu Ser Asp Lys Ile Val Glu Ile Ile Asn Glu Glu Leu Trp
              20                  25                  30        
 Pro Asn Pro Leu Gln Phe Tyr Leu Leu Ser Glu Gly Ala Arg Val Glu
          35                  40                  45            
 Lys Gly Lys Glu Lys Glu Gly Arg Gln Gly Pro Gly Lys Gln Pro Met
      50                  55                  60                
 Glu Thr Thr Gln Pro Gly Val Ser Lys Ser Asn
  65                  70                  75



      <210> 1602
      <211> 328
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(328)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1602
 Asn Ser Arg Val Asp Asp Phe Val Gly Lys Met Ala Ala Ser Arg Asn
   1               5                  10                  15    
 Gly Phe Glu Ala Val Glu Ala Glu Gly Ser Ala Gly Cys Arg Gly Ser
              20                  25                  30        
 Ser Gly Met Glu Val Val Leu Pro Leu Asp Pro Ala Val Pro Ala Pro
          35                  40                  45            
 Leu Cys Pro His Gly Pro Thr Leu Leu Phe Val Lys Val Thr Gln Gly
      50                  55                  60                
 Lys Glu Glu Thr Arg Arg Phe Tyr Ala Cys Ser Ala Cys Arg Asp Arg
  65                  70                  75                  80
 Lys Asp Cys Asn Phe Phe Gln Trp Glu Glu Xaa Lys Val Val Arg Ser
                  85                  90                  95    
 Xaa Thr Cys Cys Pro Arg Ser Ser Xaa Pro Lys Asp Val Ser Leu Pro
             100                 105                 110        
 Cys Pro Glu Arg Ser Val Trp Lys Gly Thr Xaa Ser Leu Leu Ser Cys
         115                 120                 125            
 Pro Cys His Gln Arg Lys Phe Cys Gln Thr Cys Gln Gln Leu Leu Leu
     130                 135                 140                
 Pro Asp Asp Trp Gly Gln His Ser Glu His Gln Val Leu Gly Asn Val
 145                 150                 155                 160
 Ser Ile Thr Gln Leu Arg Arg Pro Ser Gln Leu Leu Tyr Pro Leu Glu
                 165                 170                 175    
 Asn Lys Lys Thr Asn Ala Gln Tyr Leu Phe Ala Asp Arg Ser Cys Gln
             180                 185                 190        
 Phe Leu Val Asp Leu Leu Ser Ala Leu Gly Phe Arg Arg Val Leu Cys
         195                 200                 205            
 Val Gly Thr Pro Arg Leu His Glu Leu Ile Lys Leu Thr Ala Ser Gly
     210                 215                 220                
 Asp Lys Lys Ser Asn Ile Lys Ser Leu Leu Leu Asp Ile Asp Phe Arg
 225                 230                 235                 240
 Tyr Ser Gln Phe Phe Met Glu Asp Ser Phe Cys His Tyr Asn Met Phe
                 245                 250                 255    
 Asn His His Phe Phe Asp Gly Lys Thr Ala Leu Glu Val Cys Arg Ala
             260                 265                 270        
 Phe Leu Gln Glu Asp Lys Gly Glu Gly Ile Ile Met Val Thr Asp Pro
         275                 280                 285            
 Pro Phe Gly Gly Leu Val Glu Pro Leu Ala Ile Thr Phe Lys Lys Leu
     290                 295                 300                
 Ile Ala Met Trp Lys Glu Gly Gln Ser Gln Gly Val Xaa Phe Ile Thr
 305                 310                 315                 320
 Ala Lys Xaa Ile His Ile Tyr Ile
                 325            



      <210> 1603
      <211> 503
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(503)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1603
 Ser Ala Ala Pro Gly Ala Val Pro Pro Pro Glu Ala Asp Ser Thr Ser
   1               5                  10                  15    
 Ala Gly Met Ser Arg Arg Pro Cys Ser Cys Ala Leu Arg Pro Pro Arg
              20                  25                  30        
 Cys Ser Cys Ser Ala Ser Pro Ser Ala Val Thr Ala Ala Gly Arg Pro
          35                  40                  45            
 Arg Pro Ser Asp Ser Cys Lys Glu Glu Ser Ser Thr Leu Ser Val Lys
      50                  55                  60                
 Met Lys Cys Asp Phe Asn Cys Asn His Val His Ser Gly Leu Lys Leu
  65                  70                  75                  80
 Val Lys Pro Asp Asp Ile Gly Arg Leu Val Ser Tyr Asn Pro Ala Tyr
                  85                  90                  95    
 Leu Glu Gly Ser Cys Lys Asp Cys Ile Lys Asp Tyr Glu Arg Leu Ser
             100                 105                 110        
 Cys Ile Gly Ser Pro Ile Val Ser Pro Arg Ile Val Gln Leu Glu Thr
         115                 120                 125            
 Glu Ser Lys Arg Leu His Asn Lys Glu Asn Gln His Val Gln Gln Thr
     130                 135                 140                
 Leu Asn Ser Thr Asn Glu Ile Glu Ala Leu Glu Thr Ser Arg Leu Tyr
 145                 150                 155                 160
 Glu Asp Ser Gly Tyr Ser Ser Phe Ser Leu Gln Ser Gly Leu Ser Glu
                 165                 170                 175    
 His Glu Glu Gly Ser Leu Leu Glu Glu Asn Phe Gly Asp Ser Leu Gln
             180                 185                 190        
 Ser Cys Leu Leu Gln Ile Gln Ser Pro Asp Gln Tyr Pro Asn Lys Asn
         195                 200                 205            
 Leu Leu Pro Val Leu His Phe Glu Lys Val Val Cys Ser Thr Leu Lys
     210                 215                 220                
 Lys Asn Ala Lys Arg Asn Pro Lys Val Asp Arg Glu Met Leu Lys Glu
 225                 230                 235                 240
 Ile Ile Ala Arg Gly Asn Phe Arg Leu Gln Asn Ile Ile Gly Arg Lys
                 245                 250                 255    
 Met Gly Leu Glu Cys Val Asp Ile Leu Ser Glu Leu Phe Arg Arg Gly
             260                 265                 270        
 Leu Arg His Val Leu Ala Thr Ile Leu Ala Gln Leu Ser Asp Met Asp
         275                 280                 285            
 Leu Ile Asn Val Ser Lys Val Ser Thr Thr Trp Lys Lys Ile Leu Glu
     290                 295                 300                
 Asp Asp Lys Gly Ala Phe Gln Leu Tyr Ser Lys Ala Ile Gln Arg Val
 305                 310                 315                 320
 Thr Glu Asn Asn Asn Lys Phe Ser Pro His Ala Ser Thr Arg Glu Tyr
                 325                 330                 335    
 Val Met Phe Arg Thr Pro Leu Ala Ser Val Gln Lys Ser Ala Ala Gln
             340                 345                 350        
 Thr Ser Leu Lys Lys Asp Ala Gln Thr Lys Leu Ser Asn Gln Gly Asp
         355                 360                 365            
 Gln Lys Gly Ser Thr Tyr Ser Arg His Asn Glu Phe Ser Glu Val Ala
     370                 375                 380                
 Lys Thr Leu Lys Lys Asn Glu Ser Leu Lys Ala Cys Ile Arg Cys Asn
 385                 390                 395                 400
 Ser Pro Ala Lys Tyr Asp Cys Tyr Leu Gln Arg Ala Thr Cys Lys Arg
                 405                 410                 415    
 Glu Gly Cys Gly Phe Asp Tyr Cys Thr Lys Cys Leu Cys Asn Tyr His
             420                 425                 430        
 Thr Thr Lys Asp Cys Ser Asp Gly Lys Leu Leu Lys Ala Ser Cys Lys
         435                 440                 445            
 Ile Gly Pro Leu Pro Gly Thr Lys Lys Ser Lys Lys Asn Leu Xaa Arg
     450                 455                 460                
 Leu His Val Gly Trp His Glu Pro Ala Pro Leu Gln Leu Arg Pro Thr
 465                 470                 475                 480
 Ala Thr Pro Leu Leu Leu Gln Arg Gln Pro Gln Arg Ser Asp Ser Arg
                 485                 490                 495    
 Arg Ala Pro Ser Thr Leu Gly
             500            



      <210> 1604
      <211> 234
      <212> PRT
      <213> Homo sapiens


      <400> 1604
 Leu Leu Arg Lys Val Gly Ala Pro Gly Gly Ala Arg Gly Val Ile Arg
   1               5                  10                  15    
 Leu Leu Asp Trp Phe Glu Arg Pro Asp Gly Phe Leu Leu Val Leu Glu
              20                  25                  30        
 Arg Pro Glu Pro Ala Gln Asp Leu Phe Asp Phe Ile Thr Glu Arg Gly
          35                  40                  45            
 Ala Leu Asp Glu Pro Leu Ala Arg Arg Phe Phe Ala Gln Val Leu Ala
      50                  55                  60                
 Ala Val Arg His Cys His Ser Cys Gly Val Val His Arg Asp Ile Lys
  65                  70                  75                  80
 Asp Glu Asn Leu Leu Val Asp Leu Arg Ser Gly Glu Leu Lys Leu Ile
                  85                  90                  95    
 Asp Phe Gly Ser Gly Ala Leu Leu Lys Asp Thr Val Tyr Thr Asp Phe
             100                 105                 110        
 Asp Gly Thr Arg Val Tyr Ser Pro Pro Glu Trp Ile Arg Tyr His Arg
         115                 120                 125            
 Tyr His Gly Arg Ser Ala Thr Val Trp Ser Leu Gly Val Leu Leu Tyr
     130                 135                 140                
 Asp Met Val Cys Gly Asp Ile Pro Phe Glu Gln Asp Glu Glu Ile Leu
 145                 150                 155                 160
 Arg Gly Arg Leu Leu Phe Arg Arg Arg Val Ser Pro Glu Cys Gln Gln
                 165                 170                 175    
 Leu Ile Arg Trp Cys Leu Ser Leu Arg Pro Ser Glu Arg Pro Ser Leu
             180                 185                 190        
 Asp Gln Ile Ala Ala His Pro Trp Met Leu Gly Ala Asp Gly Gly Ala
         195                 200                 205            
 Pro Glu Ser Cys Asp Leu Arg Leu Cys Thr Leu Asp Pro Asp Asp Val
     210                 215                 220                
 Ala Ser Thr Thr Ser Ser Ser Glu Ser Leu
 225                 230                



      <210> 1605
      <211> 908
      <212> PRT
      <213> Homo sapiens


      <400> 1605
 Pro Ala His Pro Lys Gly Glu Leu Leu Lys Arg Val Leu Asn Pro Leu
   1               5                  10                  15    
 Leu Pro Tyr Gly Pro Ala Leu Ile Glu His Cys Leu Leu Glu Asn Gly
              20                  25                  30        
 Phe Ser Gly Asn Val Lys Val Asp Glu Lys Leu Glu Thr Lys Asp Ile
          35                  40                  45            
 Glu Lys Val Leu Val Ser Leu Gln Lys Ala Glu Asp Tyr Met Lys Thr
      50                  55                  60                
 Thr Ser Asn Phe Ser Gly Lys Gly Tyr Ile Ile Gln Lys Arg Glu Ile
  65                  70                  75                  80
 Lys Pro Cys Leu Glu Ala Asp Lys Pro Val Glu Asp Ile Leu Thr Tyr
                  85                  90                  95    
 Glu Glu Phe His Pro Phe Leu Phe Ser Gln His Ser Gln Cys Pro Tyr
             100                 105                 110        
 Ile Glu Phe Glu Ser Phe Asp Lys Ala Val Asp Glu Phe Tyr Ser Lys
         115                 120                 125            
 Ile Glu Gly Gln Lys Ile Asp Leu Lys Ala Leu Gln Gln Glu Lys Gln
     130                 135                 140                
 Ala Leu Lys Lys Leu Asp Asn Val Arg Lys Asp His Glu Asn Arg Leu
 145                 150                 155                 160
 Glu Ala Leu Gln Gln Ala Gln Glu Ile Asp Lys Leu Lys Gly Glu Leu
                 165                 170                 175    
 Ile Glu Met Asn Leu Gln Ile Val Asp Arg Ala Ile Gln Val Val Arg
             180                 185                 190        
 Ser Ala Leu Ala Asn Gln Ile Asp Trp Thr Glu Ile Gly Leu Ile Val
         195                 200                 205            
 Lys Glu Ala Gln Ala Gln Gly Asp Pro Val Ala Ser Ala Ile Lys Glu
     210                 215                 220                
 Leu Lys Leu Gln Thr Asn His Val Thr Met Leu Leu Arg Asn Pro Tyr
 225                 230                 235                 240
 Leu Leu Ser Glu Glu Glu Asp Asp Asp Val Asp Gly Asp Val Asn Val
                 245                 250                 255    
 Glu Lys Asn Glu Thr Glu Pro Pro Lys Gly Lys Lys Lys Lys Gln Lys
             260                 265                 270        
 Asn Lys Gln Leu Gln Lys Pro Gln Lys Asn Lys Pro Leu Leu Val Asp
         275                 280                 285            
 Val Asp Leu Ser Leu Ser Ala Tyr Ala Asn Ala Lys Lys Tyr Tyr Asp
     290                 295                 300                
 His Lys Arg Tyr Ala Ala Lys Lys Thr Gln Lys Thr Val Glu Ala Ala
 305                 310                 315                 320
 Glu Lys Ala Phe Lys Ser Ala Glu Lys Lys Thr Lys Gln Thr Leu Lys
                 325                 330                 335    
 Glu Val Gln Thr Val Thr Ser Ile Gln Lys Ala Arg Lys Val Tyr Trp
             340                 345                 350        
 Phe Glu Lys Phe Leu Trp Phe Ile Ser Ser Glu Asn Tyr Leu Ile Ile
         355                 360                 365            
 Gly Gly Arg Asp Gln Gln Gln Asn Glu Ile Ile Val Lys Arg Tyr Leu
     370                 375                 380                
 Thr Pro Gly Asp Ile Tyr Val His Ala Asp Leu His Gly Ala Thr Ser
 385                 390                 395                 400
 Cys Val Ile Lys Asn Pro Thr Gly Glu Pro Ile Pro Pro Arg Thr Leu
                 405                 410                 415    
 Thr Glu Ala Gly Thr Met Ala Leu Cys Tyr Ser Ala Ala Trp Asp Ala
             420                 425                 430        
 Arg Val Ile Thr Ser Ala Trp Trp Val Tyr His His Gln Val Ser Lys
         435                 440                 445            
 Thr Ala Pro Thr Gly Glu Tyr Leu Thr Thr Gly Ser Phe Met Ile Arg
     450                 455                 460                
 Gly Lys Lys Asn Phe Leu Pro Pro Ser Tyr Leu Met Met Gly Phe Ser
 465                 470                 475                 480
 Phe Leu Phe Lys Val Asp Glu Ser Cys Val Trp Arg His Gln Gly Glu
                 485                 490                 495    
 Arg Lys Val Arg Val Gln Asp Glu Asp Met Glu Thr Leu Ala Ser Cys
             500                 505                 510        
 Thr Ser Glu Leu Ile Ser Glu Glu Met Glu Gln Leu Asp Gly Gly Asp
         515                 520                 525            
 Thr Ser Ser Asp Glu Asp Lys Glu Glu His Glu Thr Pro Val Glu Val
     530                 535                 540                
 Glu Leu Met Thr Gln Val Asp Gln Glu Asp Ile Thr Leu Gln Ser Gly
 545                 550                 555                 560
 Arg Asp Glu Leu Asn Glu Glu Leu Ile Gln Glu Glu Ser Ser Glu Asp
                 565                 570                 575    
 Glu Gly Glu Tyr Glu Glu Val Arg Lys Asp Gln Asp Ser Val Gly Glu
             580                 585                 590        
 Met Lys Asp Glu Gly Glu Glu Thr Leu Asn Tyr Pro Asp Thr Thr Ile
         595                 600                 605            
 Asp Leu Ser His Leu Gln Pro Gln Arg Ser Ile Gln Lys Leu Ala Ser
     610                 615                 620                
 Lys Glu Glu Ser Ser Asn Ser Ser Asp Ser Lys Ser Gln Ser Arg Arg
 625                 630                 635                 640
 His Leu Ser Ala Lys Glu Arg Arg Glu Met Lys Lys Lys Lys Leu Pro
                 645                 650                 655    
 Ser Asp Ser Gly Asp Leu Glu Ala Leu Glu Gly Lys Asp Lys Glu Lys
             660                 665                 670        
 Glu Ser Thr Val His Ile Glu Thr His Gln Asn Thr Ser Lys Asn Val
         675                 680                 685            
 Ala Ala Val Gln Pro Met Lys Arg Gly Gln Lys Ser Lys Met Lys Lys
     690                 695                 700                
 Met Lys Glu Lys Tyr Lys Asp Gln Asp Glu Glu Asp Arg Glu Leu Ile
 705                 710                 715                 720
 Met Lys Leu Leu Gly Ser Ala Gly Ser Asn Lys Glu Glu Lys Gly Lys
                 725                 730                 735    
 Lys Gly Lys Lys Gly Lys Thr Lys Asp Glu Pro Val Lys Lys Gln Pro
             740                 745                 750        
 Gln Lys Pro Arg Gly Gly Gln Arg Val Ser Asp Asn Ile Lys Lys Glu
         755                 760                 765            
 Thr Pro Phe Leu Glu Val Ile Thr His Glu Leu Gln Asp Phe Ala Val
     770                 775                 780                
 Asp Asp Pro His Asp Asp Lys Glu Glu Gln Asp Leu Asp Gln Gln Gly
 785                 790                 795                 800
 Asn Glu Glu Asn Leu Phe Asp Ser Leu Thr Gly Gln Pro His Pro Glu
                 805                 810                 815    
 Asp Val Leu Leu Phe Ala Ile Pro Ile Cys Ala Pro Tyr Thr Thr Met
             820                 825                 830        
 Thr Asn Tyr Lys Tyr Lys Val Lys Leu Thr Pro Gly Val Gln Lys Lys
         835                 840                 845            
 Gly Lys Ala Ala Lys Thr Ala Leu Asn Ser Phe Met His Ser Lys Glu
     850                 855                 860                
 Ala Thr Ala Arg Glu Lys Asp Leu Phe Arg Ser Val Lys Asp Thr Asp
 865                 870                 875                 880
 Leu Ser Arg Asn Ile Pro Gly Lys Val Lys Ser Val Cys Thr Gln Ser
                 885                 890                 895    
 Ser Glu Arg Lys Lys Glu Ile Ala Glu Met Lys Phe
             900                 905            



      <210> 1606
      <211> 326
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(326)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1606
 His His Glu Leu His Thr Leu Glu Leu Leu Gln Asn Pro Lys Glu Val
   1               5                  10                  15    
 Leu Thr Arg Ser Glu Ile Gln Asp Val Asn Tyr Ser Leu Glu Ala Val
              20                  25                  30        
 Lys Val Lys Thr Val Cys Gln Ile Pro Leu Met Lys Glu Met Leu Lys
          35                  40                  45            
 Arg Phe Gln Val Ala Val Asn Leu Ala Glu Asp Thr Ala His Pro Lys
      50                  55                  60                
 Leu Val Phe Ser Gln Glu Gly Arg Tyr Val Lys Asn Thr Ala Ser Ala
  65                  70                  75                  80
 Ser Ser Trp Pro Val Phe Ser Ser Ala Trp Asn Tyr Phe Ala Gly Trp
                  85                  90                  95    
 Arg Asn Pro Gln Lys Thr Ala Phe Val Glu Arg Phe Gln His Leu Ser
             100                 105                 110        
 Cys Val Leu Gly Lys Asn Val Phe Thr Ser Gly Lys His Tyr Trp Glu
         115                 120                 125            
 Val Glu Ser Arg Asp Ser Leu Glu Val Ala Val Gly Val Cys Arg Glu
     130                 135                 140                
 Asp Val Met Gly Ile Thr Asp Arg Ser Lys Met Ser Pro Asp Val Gly
 145                 150                 155                 160
 Ile Trp Ala Ile Tyr Trp Ser Ala Ala Gly Tyr Trp Pro Leu Ile Gly
                 165                 170                 175    
 Phe Pro Gly Thr Pro Thr Gln Gln Glu Pro Ala Leu His Arg Val Gly
             180                 185                 190        
 Val Tyr Leu Asp Arg Gly Thr Gly Asn Val Ser Phe Tyr Ser Ala Val
         195                 200                 205            
 Asp Gly Val His Leu His Thr Phe Ser Cys Ser Ser Val Ser Arg Leu
     210                 215                 220                
 Arg Pro Phe Phe Trp Leu Ser Pro Leu Ala Ser Leu Val Ile Pro Pro
 225                 230                 235                 240
 Val Thr Asp Arg Lys Xaa Gly Phe Ser Ser Pro Asp Gln Asn Ser Phe
                 245                 250                 255    
 Pro Val Val Gln Leu Arg Asp Thr His Pro Trp Ala Leu Phe Cys Pro
             260                 265                 270        
 Ser Cys Leu Tyr Pro Gly Trp Ser Ile Phe Trp Val Ser Leu Thr Val
         275                 280                 285            
 Pro Phe Gly Ile Cys Pro Leu Cys Ala Ser Gln Glu Ala Val Pro Trp
     290                 295                 300                
 Glu Val Gly Leu Ala Asn Gly Asp Gly Thr Gly Asn Phe Pro Arg Arg
 305                 310                 315                 320
 Phe Trp Glu Ile Phe Leu
                 325    



      <210> 1607
      <211> 131
      <212> PRT
      <213> Homo sapiens


      <400> 1607
 Ser Arg Trp Gly Pro Ser Pro Ser Leu Ser Ala Pro Ala Val Ser Gln
   1               5                  10                  15    
 Ala Ser Val Ser Glu Asp Ala Gln Glu Gly Gln Gly Ala Ala Ser Ala
              20                  25                  30        
 Gly Ser Arg Leu Leu Ser Ser Leu Lys Cys Gly Thr His His Arg Gly
          35                  40                  45            
 Pro Cys Ala Leu Cys Arg Ala Leu Pro Pro Arg Gly Ala Ala Ser Pro
      50                  55                  60                
 Pro Ala Ala Leu Pro Cys Cys Ala Ala Leu Arg Arg Gly Pro Val Cys
  65                  70                  75                  80
 Cys His Pro Gly Ala Val Arg Ser Asp Val Val Thr Trp Val Phe Met
                  85                  90                  95    
 Val His Glu Gln Leu Val Asp Leu Gln His His Leu Leu Arg Glu His
             100                 105                 110        
 Pro Gln Gly Glu Gly Phe Asp Leu Gly Ala Arg Ile Ser Thr Glu Lys
         115                 120                 125            
 Ser Lys Ser
     130    



      <210> 1608
      <211> 222
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(222)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1608
 Ser Arg Leu Gly Arg Asp His Val Gly Pro Gly Leu Gly Gly Val Gly
   1               5                  10                  15    
 Val Arg Arg Arg Glu Asn Asp Ile Gly Glu Tyr Glu Gly Gly Arg Asn
              20                  25                  30        
 Glu Ala Gly Glu Arg His Gly Arg Gly Arg Ala Arg Leu Pro Asn Gly
          35                  40                  45            
 Asp Thr Tyr Glu Gly Ser Tyr Glu Phe Gly Lys Arg His Gly Gln Gly
      50                  55                  60                
 Ile Tyr Lys Phe Lys Asn Gly Ala Arg Tyr Ile Gly Glu Tyr Val Arg
  65                  70                  75                  80
 Asn Lys Lys His Gly Gln Gly Thr Phe Ile Tyr Pro Asp Gly Ser Arg
                  85                  90                  95    
 Tyr Glu Gly Glu Trp Ala Asn Asp Leu Arg His Gly His Gly Val Tyr
             100                 105                 110        
 Tyr Tyr Ile Asn Asn Asp Thr Tyr Thr Gly Glu Trp Phe Ala His Gln
         115                 120                 125            
 Arg His Gly Gln Gly Thr Tyr Leu Tyr Ala Glu Thr Gly Ser Lys Tyr
     130                 135                 140                
 Val Gly Thr Trp Val Asn Gly Gln Gln Glu Gly Thr Ala Glu Leu Ile
 145                 150                 155                 160
 His Leu Asn His Arg Tyr Gln Gly Lys Phe Leu Asn Lys Asn Pro Val
                 165                 170                 175    
 Gly Pro Ala Lys Val Cys Ile Xaa Cys Trp Val Xaa Thr Thr Trp Xaa
             180                 185                 190        
 Ile Ser Phe Asn Arg Tyr Gly Lys Arg Arg Arg Gly Arg Gly Gly Arg
         195                 200                 205            
 Ile Ser Asn Cys Cys Ser Lys Met Glu Ser Tyr Pro Asn His
     210                 215                 220        



      <210> 1609
      <211> 222
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(222)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1609
 Ser Arg Leu Gly Arg Asp His Val Gly Pro Gly Leu Gly Gly Val Gly
   1               5                  10                  15    
 Val Arg Arg Arg Glu Asn Asp Ile Gly Glu Tyr Glu Gly Gly Arg Asn
              20                  25                  30        
 Glu Ala Gly Glu Arg His Gly Arg Gly Arg Ala Arg Leu Pro Asn Gly
          35                  40                  45            
 Asp Thr Tyr Glu Gly Ser Tyr Glu Phe Gly Lys Arg His Gly Gln Gly
      50                  55                  60                
 Ile Tyr Lys Phe Lys Asn Gly Ala Arg Tyr Ile Gly Glu Tyr Val Arg
  65                  70                  75                  80
 Asn Lys Lys His Gly Gln Gly Thr Phe Ile Tyr Pro Asp Gly Ser Arg
                  85                  90                  95    
 Tyr Glu Gly Glu Trp Ala Asn Asp Leu Arg His Gly His Gly Val Tyr
             100                 105                 110        
 Tyr Tyr Ile Asn Asn Asp Thr Tyr Thr Gly Glu Trp Phe Ala His Gln
         115                 120                 125            
 Arg His Gly Gln Gly Thr Tyr Leu Tyr Ala Glu Thr Gly Ser Lys Tyr
     130                 135                 140                
 Val Gly Thr Trp Val Asn Gly Gln Gln Glu Gly Thr Ala Glu Leu Ile
 145                 150                 155                 160
 His Leu Asn His Arg Tyr Gln Gly Lys Phe Leu Asn Lys Asn Pro Val
                 165                 170                 175    
 Gly Pro Ala Lys Val Cys Ile Xaa Cys Trp Val Xaa Thr Thr Trp Xaa
             180                 185                 190        
 Ile Ser Phe Asn Arg Tyr Gly Lys Arg Arg Arg Gly Arg Gly Gly Arg
         195                 200                 205            
 Ile Ser Asn Cys Cys Ser Lys Met Glu Ser Tyr Pro Asn His
     210                 215                 220        



      <210> 1610
      <211> 62
      <212> PRT
      <213> Homo sapiens


      <400> 1610
 Arg Ile Ser Asp Lys Val Val Gly Ile Leu Met Arg Ala Arg Lys His
   1               5                  10                  15    
 Gly Leu Val Asp Phe Glu Gly Glu Met Leu Trp Gln Gly Arg Asp Asp
              20                  25                  30        
 His Val Val Ile Thr Leu Leu Lys Ser Asn Leu Gln Lys Gln Lys Pro
          35                  40                  45            
 Asn Leu Ala His Tyr Gly Leu Asn Ala Lys Cys Ser Cys Arg
      50                  55                  60        



      <210> 1611
      <211> 635
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(635)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1611
 Thr Pro Pro Pro Pro Pro Pro Ala Pro Pro Ala Gln Leu Pro Cys Pro
   1               5                  10                  15    
 Gln Cys Ser Lys Ser Phe Ala Ser Ala Ser Arg Leu Ser Arg His Arg
              20                  25                  30        
 Arg Ala Val His Gly Pro Pro Glu Arg Arg His Arg Cys Gly Val Cys
          35                  40                  45            
 Gly Lys Gly Phe Lys Lys Leu Ile His Val Arg Asn His Leu Arg Thr
      50                  55                  60                
 His Thr Gly Glu Arg Pro Phe Gln Cys His Ser Cys Gly Lys Thr Phe
  65                  70                  75                  80
 Ala Ser Leu Ala Asn Leu Ser Arg His Gln Leu Thr His Thr Gly Ala
                  85                  90                  95    
 Arg Pro Tyr Gln Cys Leu Asp Cys Gly Lys Arg Phe Thr Gln Ser Ser
             100                 105                 110        
 Asn Leu Gln Gln His Arg Arg Leu His Leu Arg Pro Val Ala Phe Ala
         115                 120                 125            
 Arg Ala Pro Arg Leu Pro Ile Thr Gly Leu Tyr Asn Lys Ser Pro Tyr
     130                 135                 140                
 Tyr Cys Gly Thr Cys Gly Arg Trp Phe Arg Ala Met Ala Gly Leu Arg
 145                 150                 155                 160
 Leu His Gln Arg Val His Ala Arg Cys Ser Asp Cys Xaa Arg Tyr Ser
                 165                 170                 175    
 Leu Pro Asp His His Leu Leu Pro His Pro His Leu Gln Ser Leu Asn
             180                 185                 190        
 Arg Pro Ile Met Cys Thr Glu Leu Gly Glu Thr Ile Ala Ile Ile Glu
         195                 200                 205            
 Thr Ser Gln Pro Leu Ala Leu Glu Asp Thr Leu Gln Leu Cys Gln Ala
     210                 215                 220                
 Ala Leu Gly Ala Ser Glu Ala Gly Gly Leu Leu Gln Leu Asp Thr Ala
 225                 230                 235                 240
 Phe Val Xaa Arg Ser Xaa Lys Ala Thr Thr Lys Gly Phe Gly Cys Asn
                 245                 250                 255    
 Ser Gln Cys Gly Tyr Leu Trp Gly Glu Arg Thr Ser Leu Thr Asn Trp
             260                 265                 270        
 Ser Gly Thr His His Val Pro Gly Ser Thr Leu Ala Ser Phe Tyr Pro
         275                 280                 285            
 Leu Thr Pro Gln Asn Asn Pro Ser Arg Leu Leu Leu Ser Ser Phe Ser
     290                 295                 300                
 Ala Xaa Gly Glu Thr Glu Ala Leu Lys Cys Asp Val Ile Cys Thr Arg
 305                 310                 315                 320
 Ser Pro Ser Tyr Ala Ala Lys Trp Val Gly Lys Ala Leu Cys Thr Ala
                 325                 330                 335    
 Ser Pro Trp Cys Pro Ala Thr Ser Gly Asn Leu His Xaa Ala Pro Ser
             340                 345                 350        
 Leu Cys Gln Val Cys Gly Trp Pro Leu Ser Tyr Thr Ser Ser Asp Pro
         355                 360                 365            
 Leu Leu Val Pro Pro Ala Leu Ala Phe Pro Gly Phe Trp Ala Pro Arg
     370                 375                 380                
 Thr Leu Leu Cys Leu Val Glu Gly Thr Xaa Phe Leu Trp Ala Ser Phe
 385                 390                 395                 400
 Ile Ser Ile Leu Thr Val Trp Lys Glu Ile Cys Arg Tyr Pro Gly Pro
                 405                 410                 415    
 Gln Leu Gln Thr Gly Xaa Cys Trp Arg Pro Arg Ser Lys Ser Ala Gln
             420                 425                 430        
 Ala Leu Pro Thr Gly Gly Met His Asn Leu Val Gly Glu Thr His Lys
         435                 440                 445            
 Tyr Arg Xaa Leu Ala Leu Xaa Val Cys Leu Ile Asp Ser Phe Ser Leu
     450                 455                 460                
 Cys Val Leu Lys Pro Pro Phe Ser His Thr Gly Xaa Cys Trp Gly Gln
 465                 470                 475                 480
 Arg Xaa Val Arg Pro Lys Ala Ser Leu Gly Cys Asp Gly Asp Val Gln
                 485                 490                 495    
 Gly Gln Trp Asp Pro Arg Lys Gln Thr Ser Met Val Gly Asp His Glu
             500                 505                 510        
 Leu Arg Thr Ser Xaa Arg Arg Xaa Ser Leu Lys Glu Lys Xaa Glu Ser
         515                 520                 525            
 Gly Ser Glu Arg Gly Lys Glu His Ser Arg Gln Thr Ala Leu Gln Glu
     530                 535                 540                
 Gly Glu Leu Leu Val Tyr Leu Glu Thr Ile Gln Leu Phe Ile Xaa Leu
 545                 550                 555                 560
 Pro Thr Xaa Gly Lys His His Thr Tyr His Cys Met Cys Thr Met Ile
                 565                 570                 575    
 Pro Thr Gly Leu Xaa His Arg Phe His Ile Ile Pro Val Val Xaa Ile
             580                 585                 590        
 Phe Lys Thr Gly Gly Trp Ala Trp Trp Leu Thr Pro Val Ile Pro Ala
         595                 600                 605            
 Leu Trp Glu Ala Glu Ala Gly Arg Ser Arg Gly Gln Glu Ile Glu Thr
     610                 615                 620                
 Ile Leu Ala Asn Thr Val Lys Pro Arg Leu Tyr
 625                 630                 635



      <210> 1612
      <211> 69
      <212> PRT
      <213> Homo sapiens


      <400> 1612
 Cys Val Ser Leu Val His Leu Leu Leu Thr Leu Ser Trp Leu Gly Asp
   1               5                  10                  15    
 Cys Trp Leu Phe Leu Gly Gln Val Leu Gly Arg Pro Gly Phe Ser Ile
              20                  25                  30        
 Ala Asp Lys Lys Arg Arg Thr Gly Cys Ile Gly Ala Lys His Arg Ile
          35                  40                  45            
 Ser Lys Glu Glu Ala Met Arg Trp Phe Gln Gln Lys Tyr Asp Gly Ile
      50                  55                  60                
 Ile Leu Pro Gly Lys
  65                



      <210> 1613
      <211> 149
      <212> PRT
      <213> Homo sapiens


      <400> 1613
 Gly Arg Pro Thr Arg Pro Arg Thr Arg Gly Gly Pro Ala Asn Met Gly
   1               5                  10                  15    
 Arg Val Arg Thr Lys Thr Val Lys Lys Ala Ala Arg Val Ile Ile Glu
              20                  25                  30        
 Lys Tyr Tyr Thr Arg Leu Gly Asn Asp Phe His Thr Asn Lys Arg Val
          35                  40                  45            
 Cys Glu Glu Ile Ala Ile Ile Pro Ser Lys Lys Leu Arg Asn Lys Ile
      50                  55                  60                
 Ala Gly Tyr Val Thr His Leu Met Lys Arg Ile Gln Arg Gly Pro Val
  65                  70                  75                  80
 Arg Gly Ile Ser Ile Lys Leu Gln Glu Glu Glu Arg Glu Arg Arg Asp
                  85                  90                  95    
 Asn Tyr Val Pro Glu Val Ser Ala Leu Asp Gln Glu Ile Ile Glu Val
             100                 105                 110        
 Asp Pro Asp Thr Lys Glu Met Leu Lys Leu Leu Asp Phe Gly Ser Leu
         115                 120                 125            
 Ser Asn Leu Gln Val Thr Gln Pro Thr Val Gly Met Asn Phe Lys Thr
     130                 135                 140                
 Pro Arg Gly Pro Val
 145                



      <210> 1614
      <211> 1040
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1040)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1614
 Xaa Asp Arg Ile Lys Ala Leu Ser Glu Ala Leu Pro Ala Gly Arg Pro
   1               5                  10                  15    
 Cys Gly Gly Asp Arg Ser Ala Thr Asp Thr His Gly Pro Leu Ala Pro
              20                  25                  30        
 Ser Arg Leu Pro Ser Ala Arg Gln Leu Pro Ser Ala Glu Ala Ala Pro
          35                  40                  45            
 Arg Arg Pro Gln Pro Ala Arg Gly Pro His Ser Pro Pro Leu Gly Thr
      50                  55                  60                
 Pro Gly Pro Gly Ala Ala Trp Arg Arg Pro His Ser Gly Ile Met Ala
  65                  70                  75                  80
 Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser Ser Glu
                  85                  90                  95    
 Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys
             100                 105                 110        
 Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr
         115                 120                 125            
 Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val
     130                 135                 140                
 Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu
 145                 150                 155                 160
 Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln
                 165                 170                 175    
 Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys
             180                 185                 190        
 Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys
         195                 200                 205            
 Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser
     210                 215                 220                
 Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro
 225                 230                 235                 240
 Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala
                 245                 250                 255    
 Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His
             260                 265                 270        
 Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser
         275                 280                 285            
 Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu
     290                 295                 300                
 Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Glu Ala Thr Ile
 305                 310                 315                 320
 Leu Gln Arg Ala Met Lys Ala Gln Lys Trp Lys Tyr Gln Gln Lys Ile
                 325                 330                 335    
 Leu Leu Asn Met Ser Leu Ser Glu Thr Ser Glu Asp Pro Glu Val Glu
             340                 345                 350        
 Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys
         355                 360                 365            
 Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly
     370                 375                 380                
 Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile
 385                 390                 395                 400
 Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala
                 405                 410                 415    
 Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe
             420                 425                 430        
 Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile
         435                 440                 445            
 Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile
     450                 455                 460                
 Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu
 465                 470                 475                 480
 Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly
                 485                 490                 495    
 Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val
             500                 505                 510        
 Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu
         515                 520                 525            
 Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu
     530                 535                 540                
 Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp
 545                 550                 555                 560
 Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile
                 565                 570                 575    
 Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu
             580                 585                 590        
 Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val
         595                 600                 605            
 Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys
     610                 615                 620                
 Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro
 625                 630                 635                 640
 Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu
                 645                 650                 655    
 Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu
             660                 665                 670        
 Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro
         675                 680                 685            
 Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn
     690                 695                 700                
 Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn
 705                 710                 715                 720
 Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn
                 725                 730                 735    
 Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser
             740                 745                 750        
 Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp
         755                 760                 765            
 Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn
     770                 775                 780                
 Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro
 785                 790                 795                 800
 Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu
                 805                 810                 815    
 Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg
             820                 825                 830        
 Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys
         835                 840                 845            
 Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys
     850                 855                 860                
 Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala
 865                 870                 875                 880
 Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp
                 885                 890                 895    
 Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu
             900                 905                 910        
 Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met
         915                 920                 925            
 Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly
     930                 935                 940                
 Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro
 945                 950                 955                 960
 Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu
                 965                 970                 975    
 Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn
             980                 985                 990        
 Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu
         995                1000                1005            
 Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys
    1010                1015                1020                
 Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp
1025                1030                1035                1040





      <210> 1615
      <211> 321
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(321)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1615
 Pro Val Trp Trp Asn Ser Arg Glu Pro Pro Gln Ala Pro Ser Ile Lys
   1               5                  10                  15    
 Ala Asp Leu Thr Pro Pro Gln Pro Asp Val Pro Ser Ala Pro Arg Thr
              20                  25                  30        
 Val Leu Ser Pro Thr Pro Gly Phe Cys Pro Asp Leu His Pro Gly His
          35                  40                  45            
 Cys Leu Asp Asn Ile Asp Pro Ser Thr Asp Thr Leu Ala Leu Thr Pro
      50                  55                  60                
 Pro Pro Ala Phe Arg Pro His Thr Asp Asn Ser Pro Ala Ser Arg Pro
  65                  70                  75                  80
 Tyr Gln His Tyr Pro Asn Pro Gln Pro Thr Val Ser Ala Pro Pro Thr
                  85                  90                  95    
 His Phe Leu Gly Ile Xaa Pro His Leu Arg Pro Leu Leu Tyr Phe Leu
             100                 105                 110        
 Leu Ser Pro Leu Gln Arg His Pro Gly Thr Thr Phe Pro Ser Leu Pro
         115                 120                 125            
 Tyr Phe Asp Thr Lys Leu Trp Cys Arg Gln Pro Ser Pro Asn Pro Arg
     130                 135                 140                
 Pro Val Arg His Asn Pro Pro Thr Pro Gln Thr Ser Trp Thr Ala Gln
 145                 150                 155                 160
 Thr Ser His Ser Arg Pro Ser Arg Pro Gly Ser Gln Asp Pro Ile Leu
                 165                 170                 175    
 Pro Leu Gln Pro Asp Ser Leu Gln Leu Pro Pro Pro Ala His Phe Leu
             180                 185                 190        
 Pro Xaa Asn Pro Ser Gln Pro His Gln Thr Leu Glu Pro Phe Phe Asp
         195                 200                 205            
 Cys Pro Asn Ser Trp Thr Pro Gly Gln Leu Glu His Pro Thr Pro Thr
     210                 215                 220                
 Val Gln Thr Leu Pro Pro Gln Pro Pro Gln Thr Leu Pro Asp Val Leu
 225                 230                 235                 240
 Gly Pro Leu Pro Asn Ser Asn Gln Thr Pro Ser Pro Xaa Val Pro Leu
                 245                 250                 255    
 Ser Xaa Pro Pro Ser Leu Gln Pro Arg Tyr Pro Arg Gln Pro His Leu
             260                 265                 270        
 Pro Pro Ser Ser Ser Phe Ser Phe Gln Arg Pro Asn Xaa Ala Pro Ala
         275                 280                 285            
 Leu Ile Pro His Ser Leu Ser Pro Trp Ala Pro Leu Pro Xaa Ser Phe
     290                 295                 300                
 Pro Thr Pro His Arg Gln Leu Pro Gly Phe Gln Thr Leu Pro Ala Leu
 305                 310                 315                 320
 Pro
    



      <210> 1616
      <211> 159
      <212> PRT
      <213> Homo sapiens


      <400> 1616
 Phe Leu Gly Leu Pro Thr Arg Pro Ser Leu His Lys Ile Tyr Leu Cys
   1               5                  10                  15    
 Gln Ser Gly Tyr Phe Ser Ser Met Phe Ser Gly Ser Trp Lys Glu Ser
              20                  25                  30        
 Ser Met Asn Ile Ile Glu Leu Glu Ile Pro Asp Gln Asn Ile Asp Val
          35                  40                  45            
 Glu Ala Leu Gln Val Ala Phe Gly Ser Leu Tyr Arg Asp Asp Val Leu
      50                  55                  60                
 Ile Lys Pro Ser Arg Val Val Ala Ile Leu Ala Ala Ala Cys Leu Leu
  65                  70                  75                  80
 Gln Leu Asp Gly Leu Ile Gln Gln Cys Gly Glu Thr Met Lys Glu Thr
                  85                  90                  95    
 Val Asn Val Lys Thr Val Cys Gly Tyr Tyr Thr Ser Ala Gly Thr Tyr
             100                 105                 110        
 Gly Leu Asp Ser Val Lys Lys Lys Cys Leu Glu Trp Leu Leu Asn Asn
         115                 120                 125            
 Leu Met Thr His Gln Asn Val Glu Leu Phe Lys Glu Leu Ser Ile Asn
     130                 135                 140                
 Val Met Lys Gln Leu Ile Gly Ser Ser Asn Leu Phe Val Met Gln
 145                 150                 155                



      <210> 1617
      <211> 350
      <212> PRT
      <213> Homo sapiens


      <400> 1617
 Pro Ala Val Pro Gly Arg Arg Phe Arg Ala Glu Ala Ser Met Ala Glu
   1               5                  10                  15    
 Gly Gly Ser Pro Tyr Gly Arg Ala Gly Pro Gly Ser Ala Gly Arg Gly
              20                  25                  30        
 Arg Asn Leu Lys Glu Trp Leu Arg Glu Gln Phe Cys Asp His Pro Leu
          35                  40                  45            
 Glu His Cys Glu Asp Thr Arg Leu His Asp Ala Ala Tyr Val Gly Asp
      50                  55                  60                
 Leu Gln Thr Leu Arg Ser Leu Leu Gln Glu Glu Ser Tyr Arg Ser Arg
  65                  70                  75                  80
 Ile Asn Glu Lys Ser Val Trp Cys Cys Gly Trp Leu Pro Cys Thr Pro
                  85                  90                  95    
 Leu Arg Ile Ala Ala Thr Ala Gly His Gly Ser Cys Val Asp Phe Leu
             100                 105                 110        
 Ile Arg Lys Gly Ala Glu Val Asp Leu Val Asp Val Lys Gly Gln Thr
         115                 120                 125            
 Ala Leu Tyr Val Ala Val Val Asn Gly His Leu Glu Ser Thr Gln Ile
     130                 135                 140                
 Leu Leu Glu Ala Gly Ala Asp Pro Asn Gly Ser Arg His His Arg Ser
 145                 150                 155                 160
 Thr Pro Val Tyr His Ala Ser Arg Val Gly Arg Ala Asp Ile Leu Lys
                 165                 170                 175    
 Ala Leu Ile Arg Tyr Gly Ala Asp Val Asp Val Asn His His Leu Thr
             180                 185                 190        
 Pro Asp Val Gln Pro Arg Phe Ser Arg Arg Leu Thr Ser Leu Val Val
         195                 200                 205            
 Cys Pro Leu Tyr Ile Ser Ala Ala Tyr His Asn Leu Gln Cys Phe Arg
     210                 215                 220                
 Leu Leu Leu Leu Ala Gly Ala Asn Pro Asp Phe Asn Cys Asn Gly Pro
 225                 230                 235                 240
 Val Asn Thr Gln Gly Phe Tyr Arg Gly Ser Pro Gly Cys Val Met Asp
                 245                 250                 255    
 Ala Val Leu Arg His Gly Cys Glu Ala Ala Phe Val Ser Leu Leu Val
             260                 265                 270        
 Glu Phe Gly Ala Asn Leu Asn Leu Val Lys Trp Glu Ser Leu Gly Pro
         275                 280                 285            
 Glu Ser Arg Gly Arg Arg Lys Val Asp Pro Glu Ala Leu Gln Val Phe
     290                 295                 300                
 Lys Glu Ala Arg Ser Val Pro Arg Thr Leu Leu Cys Leu Cys Arg Val
 305                 310                 315                 320
 Ala Val Arg Arg Ala Leu Gly Lys His Arg Leu His Leu Ile Pro Ser
                 325                 330                 335    
 Leu Pro Leu Pro Asp Pro Ile Lys Lys Phe Leu Leu His Glu
             340                 345                 350



      <210> 1618
      <211> 476
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(476)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1618
 Asp Cys Phe Ile Pro Ile Leu Lys Asn Asn Ser Pro Asn Asn Ser Pro
   1               5                  10                  15    
 Pro Leu Leu Glu Thr Ser Pro Asp Pro Gln Cys Pro Pro Ser Leu Ser
              20                  25                  30        
 Leu Gln Lys Ala Met Gly Val Asp Val Ser Arg Ser Trp Arg Lys Thr
          35                  40                  45            
 Lys Thr Thr Pro Pro Cys Ile Ser Ser Pro Thr Arg Leu Pro His Ile
      50                  55                  60                
 Ser Phe Val Ser Ser Pro Ile Phe Leu Pro Pro Pro Thr Ser Arg Pro
  65                  70                  75                  80
 Val Pro Leu Leu Leu Pro Pro Ala Phe Pro His Val Phe Ile Ser Val
                  85                  90                  95    
 Ser Leu Leu Val Leu Ser Pro Pro Phe Pro Ala Pro Leu Ser Ile Phe
             100                 105                 110        
 Ser Arg Leu Pro Pro Leu Leu His Leu Ser Ser Val Leu Ser Pro Phe
         115                 120                 125            
 Pro Leu Ser Pro Leu His Ser Leu Asp Trp Pro Val Tyr Ser Cys Gln
     130                 135                 140                
 Thr Leu Pro Ile Xaa Ser Leu Pro Pro Pro Pro Pro Ser Ser Ala Pro
 145                 150                 155                 160
 Phe Leu Pro Ser Val Pro Ala Xaa Pro Cys Leu His Leu Ser Ser His
                 165                 170                 175    
 Ala Ser Ser Pro Glu Gly Ser Pro Gln Asn Pro Pro Cys Pro Ser Thr
             180                 185                 190        
 Pro Ser Gln Ala Val Ala Pro Gly Pro Gln Arg Pro Leu Thr Ala Cys
         195                 200                 205            
 Pro Trp Thr Gln Arg Gly Lys Leu Pro Xaa Gly Gly Pro Trp Met Thr
     210                 215                 220                
 Gln Lys Val Ala Arg Gly Thr Ala Thr Val Ser Leu Ala Ser Ala Leu
 225                 230                 235                 240
 Leu Ser Leu Gly Ser Lys Asn Ala Leu Arg Pro Ser Trp Trp Arg Val
                 245                 250                 255    
 Val Gly Arg Gly Met Lys Gly Pro Gly Leu Trp Gly Ser Pro Pro Ala
             260                 265                 270        
 Ile Pro Glu Gln Val His Val Glu Xaa Gly Ser Pro Ser Glu Glu Ala
         275                 280                 285            
 Arg Cys Lys Glu Val Ser Cys Arg Ala Asp Gly Gly Arg Arg Glu Leu
     290                 295                 300                
 Ser Ser Cys Ser Val Ser Gly Pro His Pro Gly Arg Ser Pro Ser Ala
 305                 310                 315                 320
 Val Leu Lys Gly Lys Ala Ser Ser Gly Pro Val Glu Thr Pro Gly Pro
                 325                 330                 335    
 Met Pro Ala Xaa Gln Arg Pro Thr Pro Gln Pro Pro Gly Leu Pro Ala
             340                 345                 350        
 Leu Ala Arg Arg Leu Leu Gly Ile Trp Pro Gly Val Pro Ser Pro Pro
         355                 360                 365            
 Pro Pro Leu Pro Gly Val Gly Lys Ala Ser Leu Val Pro Trp Gly His
     370                 375                 380                
 Leu Pro Pro Pro Ser Cys Arg Pro Ser Pro Ala Ala Ser Val His Ser
 385                 390                 395                 400
 Ser Pro Leu Pro Ile Leu Gly Cys Leu Pro Ile Gln Ser Pro Pro Glu
                 405                 410                 415    
 Val Pro Asp Thr Thr Pro Phe Pro Ser Pro Arg His Arg Pro Pro Ala
             420                 425                 430        
 Ser Pro His Ser Ile Pro Arg Pro Ala Arg Leu Leu Gly Pro Thr Asp
         435                 440                 445            
 Arg Ala Pro Pro Pro Ser Pro Phe Ser Met Pro Val Thr Leu Val Ser
     450                 455                 460                
 Pro Ser Arg Thr Arg Thr Ile Ser Ser Arg Pro Leu
 465                 470                 475    



      <210> 1619
      <211> 168
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(168)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1619
 Glu Lys Leu Leu Arg Glu Ser Xaa Asp Ile Pro Ser His Leu Pro Leu
   1               5                  10                  15    
 Leu Leu Phe Gln Ala Lys Lys Ile Cys Ser Leu Arg Lys Lys Lys Met
              20                  25                  30        
 Ser Glu Thr Gln Asn Ser Thr Ser Gln Lys Ala Met Asp Glu Asp Asn
          35                  40                  45            
 Lys Ala Ala Ser Gln Thr Met Pro Asn Thr Gln Asp Lys Asn Tyr Glu
      50                  55                  60                
 Asp Glu Leu Thr Gln Val Ala Leu Ala Leu Val Glu Asp Val Ile Asn
  65                  70                  75                  80
 Tyr Ala Val Lys Ile Val Glu Glu Glu Arg Asn Pro Leu Lys Asn Ile
                  85                  90                  95    
 Lys Trp Met Thr His Gly Glu Phe Thr Val Glu Lys Gly Leu Lys Gln
             100                 105                 110        
 Ile Asp Glu Tyr Phe Ser Asp Ala Pro Ile Val Val Ser Tyr Val Gly
         115                 120                 125            
 Asp His Gln Ala Leu Val His Arg Pro Gly Met Val Arg Phe Arg Glu
     130                 135                 140                
 Asn Trp Gln Lys Asn Leu Thr Asp Ala Lys Tyr Ser Phe Met Glu Ser
 145                 150                 155                 160
 Phe Pro Phe Leu Phe Asn Arg Val
                 165            



      <210> 1620
      <211> 139
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(139)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1620
 Ser Gln His Ser Gly Arg Pro Arg Pro Ala Asp His Leu Arg Ser Gly
   1               5                  10                  15    
 Val Gln Asp Gln Pro Asp Gln His Gly Glu Thr Pro Ser Leu Leu Lys
              20                  25                  30        
 Ile Xaa Lys Leu Ala Gly Arg Gly Gly Gly Cys Leu Xaa Ser Gln Leu
          35                  40                  45            
 Leu Arg Arg Val Arg Trp Glu Asp Pro Leu Asn Pro Gly Gly Arg Gly
      50                  55                  60                
 Cys Ser Glu Pro Arg Phe Pro Pro Cys Thr Leu Gly Arg Ala Ala Lys
  65                  70                  75                  80
 Xaa Asp Phe Ile Phe Lys Lys Lys Glu Arg Lys Lys Glu Lys Lys Lys
                  85                  90                  95    
 Arg Glu Glu Leu Arg Pro Asp Arg Asp Arg Asp Gly Arg Ser Gln Arg
             100                 105                 110        
 Leu Lys Ser Arg Glu Arg Arg Gln Thr Gln Gly His Gln Gly Ser Arg
         115                 120                 125            
 Glu Ala Arg Val Pro Leu Arg Phe Gln Phe Leu
     130                 135                



      <210> 1621
      <211> 91
      <212> PRT
      <213> Homo sapiens


      <400> 1621
 Ala Ala Ala Ala Arg Ala Gly Thr Pro Gly Arg Val Gly Cys Ala Ala
   1               5                  10                  15    
 Gln Glu Val Pro Leu Ser Pro His Asn Arg Pro Gly Leu Gln Pro Leu
              20                  25                  30        
 Pro Pro Pro Pro Pro Pro Pro Pro Tyr Ser Gly Ser Gly Pro Gly Leu
          35                  40                  45            
 Arg Arg Ala Thr Leu Thr Ser Phe Ile Pro Thr Val Lys Ala Gln Pro
      50                  55                  60                
 Trp Leu Pro Asp Pro Pro Val Val Ser Asn Ser Val Ser Pro Val Lys
  65                  70                  75                  80
 Gly Gln Arg Ser Leu Gly Ser Arg Arg His His
                  85                  90    



      <210> 1622
      <211> 399
      <212> PRT
      <213> Homo sapiens


      <400> 1622
 Met Trp Ala Ala Val Gly Gly Phe Leu Phe Ala Pro Arg Cys Phe Leu
   1               5                  10                  15    
 Leu Pro Trp Pro Leu Arg Ala Pro Leu Ser Ser Leu Phe Val Leu Pro
              20                  25                  30        
 Arg Leu Leu Leu Trp Pro Ile Pro Tyr Pro Val Leu Ala Ser Val Cys
          35                  40                  45            
 Pro Cys Val Pro Gly Gly Arg Phe Phe Gly Pro Leu Tyr Pro Arg Asp
      50                  55                  60                
 Leu Arg Leu Leu Arg Cys Val Pro Gly Glu Leu Thr Gly Ala Ala Pro
  65                  70                  75                  80
 Arg Thr Leu Pro Gly Cys Asp Leu Asn Cys Leu Gly Leu Gly Arg Glu
                  85                  90                  95    
 Ala Ala Val Pro Arg Leu Leu Arg Leu Thr Arg Asp Pro Ala Arg Pro
             100                 105                 110        
 Ser Cys Arg Thr Leu Gly Val His Ala Val Pro Arg Arg Ala Phe Gly
         115                 120                 125            
 Phe Tyr Ala Val Pro Arg Arg Asp Pro Arg Phe Tyr Ala Val Pro Arg
     130                 135                 140                
 Arg Val Pro Arg Leu Tyr Ala Val Pro His Pro Ala Leu Arg Val Tyr
 145                 150                 155                 160
 Ala Val Pro Arg Arg Thr Phe Arg Val Tyr Ala Val Pro His Pro Ala
                 165                 170                 175    
 Leu Arg Val Tyr Ala Val Pro Arg Arg Ala Leu Gly Leu Tyr Val Val
             180                 185                 190        
 Pro Gln Arg Ala Leu Arg Val Tyr Ala Val Pro Arg Arg Thr Phe Arg
         195                 200                 205            
 Val Tyr Ala Val Pro His Pro Ala Leu Arg Leu Tyr Ala Val Ala Arg
     210                 215                 220                
 Arg Ala Leu Arg Phe Tyr Val Val Pro Gln Arg Ala Leu Arg Val Tyr
 225                 230                 235                 240
 Ala Val Pro Arg Leu Pro Gly Arg Ala Thr Phe Arg Asp Leu Arg Pro
                 245                 250                 255    
 Leu Leu Arg Leu Leu Leu Pro Leu Gly Gly Arg Arg Val Leu Gly Leu
             260                 265                 270        
 Pro Leu Ser Leu Pro Ala Gly Leu Ala Leu Arg Ala Ala Ser Arg Ala
         275                 280                 285            
 Arg Pro Leu His Leu Leu Arg Ala Ala Cys Leu Leu Pro Ser Leu Gly
     290                 295                 300                
 His Leu Gly Thr Leu Arg Gly Ser Leu Leu Gly Leu Ser Leu Ala Val
 305                 310                 315                 320
 Arg Pro Pro Arg Ala Pro Arg Leu Gly Leu Arg Ala Pro Val Trp Pro
                 325                 330                 335    
 Ala Ala Ser Cys Leu Leu His Ser Gly Gly Ala Pro Arg Arg Leu Leu
             340                 345                 350        
 Cys Ala Leu Ala Pro Leu Arg Pro Phe Cys Leu Pro Ala Arg Gly Ser
         355                 360                 365            
 Trp Leu Ser Gly Ser Leu Ser Gln Arg Arg Gly Asp Leu Arg Arg Pro
     370                 375                 380                
 Leu Gly Thr Arg Gly Asn Pro Leu Arg Leu Arg Gly Leu Gly His
 385                 390                 395                



      <210> 1623
      <211> 96
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(96)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1623
 Ala Ala Ala Glu Leu Gln Ala Asn Thr Ser Phe Ala Pro Ser Ala Cys
   1               5                  10                  15    
 Trp Arg Ser Leu Gln Pro Trp Ala Ala Ser Pro Thr Ala Pro Val Ala
              20                  25                  30        
 Gly Cys Pro Gly Asp Cys Pro Arg Ser Gln Arg Xaa Gly Ala Pro Pro
          35                  40                  45            
 Gly Ser Pro Gly Pro Arg Pro Pro Gly Ala Ala Pro Xaa Lys Gln Thr
      50                  55                  60                
 Ala Asn Pro Ala Ser Asn Pro Ala Ser Leu Pro Pro Thr Leu Thr Asp
  65                  70                  75                  80
 Ile Ser Gly Gln Val Pro Lys Ser Phe Gln Glu Glu Met Ser Ala Met
                  85                  90                  95    


      <210> 1624
      <211> 183
      <212> PRT
      <213> Homo sapiens


      <400> 1624
 Gly Pro Ala Ala Pro Val Ser Ser Ser Cys Ser Ser Ser Ala Ser Ser
   1               5                  10                  15    
 Ser Ala Ser Ser Ser Ser Val Val Phe Pro Gly Gly Gly Ala Ser Ala
              20                  25                  30        
 Pro Ser Asn Ala Asn Leu Gly Leu Leu Val His Arg Arg Leu His Pro
          35                  40                  45            
 Gly Thr Ser Cys Pro Arg Leu Ser Pro Pro Leu His Met Ala Pro Gly
      50                  55                  60                
 Ala Gly Glu His His Leu Ala Arg Arg Val Arg Ser Asp Pro Gly Gly
  65                  70                  75                  80
 Gly Gly Leu Ala Tyr Ala Ala Tyr Ala Asn Gly Leu Gly Ala Gln Leu
                  85                  90                  95    
 Pro Gly Leu Gln Pro Ser Asp Thr Ser Cys Ser Ser Ser Ser Ser Ser
             100                 105                 110        
 Ser Ser Ser Ser Ser Ser Ser Ser Phe Ser Gly Leu Arg Arg Lys Gly
         115                 120                 125            
 Ser Arg Asp Cys Ser Val Cys Phe Glu Ser Glu Val Ile Ala Ala Leu
     130                 135                 140                
 Val Pro Cys Gly His Asn Leu Phe Cys Met Glu Cys Ala Asn Arg Ile
 145                 150                 155                 160
 Cys Glu Lys Ser Glu Pro Glu Cys Pro Val Cys His Thr Ala Val Thr
                 165                 170                 175    
 Gln Ala Ile Arg Ile Phe Ser
             180            



      <210> 1625
      <211> 185
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(185)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1625
 Lys Arg Gly Phe Ser Met Leu Gly Val Xaa Tyr Leu His Asp Ser Thr
   1               5                  10                  15    
 Ala Asp Ser Ile Arg Thr Thr Cys Gln Gly Val Ile Ser Thr Leu Lys
              20                  25                  30        
 Ala His Tyr Leu Arg Arg Thr Phe Gln His Ile Leu Glu Ala Ala Asp
          35                  40                  45            
 Gly Glu Asp Thr Ala Met Ile Arg Glu Phe Trp Arg Asn Tyr Ser Ile
      50                  55                  60                
 Met Asp Ala Val Asp Met Ala Ile Ala Trp Glu Glu Leu Lys Pro Ala
  65                  70                  75                  80
 Leu Met Asn Ser Met Trp Lys Lys Ile Trp Pro Glu Cys Val Gln Ala
                  85                  90                  95    
 Gln Arg Phe Ser Gln Ala Asp Asn Ile Ala Gln Leu Gln Lys Asn Ile
             100                 105                 110        
 Val Thr Leu Ala Arg Asn Val Ala Phe Glu Glu Val Ala Glu Ala Ala
         115                 120                 125            
 Val Asp Gln Leu Leu Gln Ser His Glu Glu Asp Leu Ser Asn Glu Glu
     130                 135                 140                
 Leu Met Arg Leu Glu Gln Glu Leu Ala Val Gly Glu Glu Glu Arg Glu
 145                 150                 155                 160
 Asp Gly Pro Trp Ala Leu Trp Gln Leu Thr Thr Gly Arg Leu Ser Ala
                 165                 170                 175    
 Ala Leu Ser His Phe Glu Ala Gly Leu
             180                 185



      <210> 1626
      <211> 404
      <212> PRT
      <213> Homo sapiens


      <400> 1626
 Arg Arg Cys Leu Ile Ile Ala Phe Leu Lys Gly Cys Phe Ile Phe Ile
   1               5                  10                  15    
 Tyr Phe Ile Phe Ile Phe Glu Thr Glu Phe Leu Ser Cys Cys Pro Gly
              20                  25                  30        
 Trp Ser Ala Val Ala Gln Ser Arg Leu Ile Ala Asn Phe Ala Ser Gln
          35                  40                  45            
 Val Gln Ala Ile Phe Ile Leu Pro Lys Asp Ser Gln Val Gly Pro Asp
      50                  55                  60                
 Val Lys Ser Glu Ala Ala Pro Lys Arg Ala Leu Tyr Glu Ser Val Phe
  65                  70                  75                  80
 Gly Ser Gly Glu Ile Cys Gly Pro Thr Ser Pro Lys Arg Leu Cys Ile
                  85                  90                  95    
 Arg Pro Ser Glu Pro Val Asp Ala Val Val Val Val Ser Val Lys His
             100                 105                 110        
 Asp Pro Leu Pro Leu Leu Pro Glu Ala Asn Gly His Arg Ser Thr Asn
         115                 120                 125            
 Ser Pro Thr Ile Val Ser Pro Ala Ile Val Ser Pro Thr Gln Asp Ser
     130                 135                 140                
 Arg Pro Asn Met Ser Arg Pro Leu Ile Thr Arg Ser Pro Ala Ser Pro
 145                 150                 155                 160
 Leu Asn Asn Gln Gly Ile Pro Thr Pro Ala Gln Leu Thr Lys Ser Asn
                 165                 170                 175    
 Ala Pro Val His Ile Asp Val Gly Gly His Met Tyr Thr Ser Ser Leu
             180                 185                 190        
 Ala Thr Leu Thr Lys Tyr Pro Glu Ser Arg Ile Gly Arg Leu Phe Asp
         195                 200                 205            
 Gly Thr Glu Pro Ile Val Leu Asp Ser Leu Lys Gln His Tyr Phe Ile
     210                 215                 220                
 Asp Arg Asp Gly Gln Met Phe Arg Tyr Ile Leu Asn Phe Leu Arg Thr
 225                 230                 235                 240
 Ser Lys Leu Leu Ile Pro Asp Asp Phe Lys Asp Tyr Thr Leu Leu Tyr
                 245                 250                 255    
 Glu Glu Ala Lys Tyr Phe Gln Leu Gln Pro Met Leu Leu Glu Met Glu
             260                 265                 270        
 Arg Trp Lys Gln Asp Arg Glu Thr Gly Arg Phe Ser Arg Pro Cys Glu
         275                 280                 285            
 Cys Leu Val Val Arg Val Ala Pro Asp Leu Gly Glu Arg Ile Thr Leu
     290                 295                 300                
 Ser Gly Asp Lys Ser Leu Ile Glu Glu Val Phe Pro Glu Ile Gly Asp
 305                 310                 315                 320
 Val Met Cys Asn Ser Val Asn Ala Gly Trp Asn His Asp Ser Thr His
                 325                 330                 335    
 Val Ile Arg Phe Pro Leu Asn Gly Tyr Cys His Leu Asn Ser Val Gln
             340                 345                 350        
 Val Leu Glu Arg Leu Gln Gln Arg Gly Phe Glu Ile Val Gly Ser Cys
         355                 360                 365            
 Gly Gly Gly Val Asp Ser Ser Gln Phe Ser Glu Tyr Val Leu Arg Arg
     370                 375                 380                
 Glu Leu Arg Arg Thr Pro Arg Val Pro Ser Val Ile Arg Ile Lys Gln
 385                 390                 395                 400
 Glu Pro Leu Asp
                



      <210> 1627
      <211> 131
      <212> PRT
      <213> Homo sapiens


      <400> 1627
 Pro Phe Pro Ser Phe Ser Met Phe Met Gly Ala Gly Asp Ala Pro Leu
   1               5                  10                  15    
 Gly Ser Arg Pro Gly His Pro His Ser Ser Ser Gln Val Lys Ser Lys
              20                  25                  30        
 Leu Gln Ile Gly Pro Pro Ser Pro Gly Glu Ala Gln Gly Pro Leu Leu
          35                  40                  45            
 Pro Ser Pro Ala Arg Gly Leu Lys Phe Leu Lys Leu Pro Pro Thr Ser
      50                  55                  60                
 Glu Lys Ser Pro Ser Pro Gly Gly Pro Gln Leu Ser Pro Gln Leu Pro
  65                  70                  75                  80
 Arg Asn Ser Arg Ile Pro Cys Arg Asn Ser Gly Ser Asp Gly Ser Pro
                  85                  90                  95    
 Ser Pro Leu Leu Ala Arg Arg Gly Leu Gly Gly Gly Glu Leu Ser Pro
             100                 105                 110        
 Glu Gly Ala Gln Gly Leu Pro Thr Ser Pro Ser Pro Cys Tyr Thr Thr
         115                 120                 125            
 Pro Asp Cys
     130    



      <210> 1628
      <211> 319
      <212> PRT
      <213> Homo sapiens


      <400> 1628
 Asn Cys Ile Ser Glu Lys Arg Asn Tyr Ser Phe Ser Met Gln Lys Gly
   1               5                  10                  15    
 Lys Gly Arg Thr Ser Arg Ile Arg Arg Arg Lys Leu Cys Gly Ser Ser
              20                  25                  30        
 Glu Ser Arg Gly Val Asn Glu Ser His Lys Ser Glu Phe Ile Glu Leu
          35                  40                  45            
 Arg Lys Trp Leu Lys Ala Arg Lys Phe Gln Asp Ser Asn Leu Ala Pro
      50                  55                  60                
 Ala Cys Phe Pro Gly Thr Gly Arg Gly Leu Met Ser Gln Thr Ser Leu
  65                  70                  75                  80
 Gln Glu Gly Gln Met Ile Ile Ser Leu Pro Glu Ser Cys Leu Leu Thr
                  85                  90                  95    
 Arg Asp Thr Val Ile Arg Ser Tyr Leu Gly Ala Tyr Ile Thr Lys Trp
             100                 105                 110        
 Lys Pro Pro Pro Ser Pro Leu Leu Ala Leu Cys Thr Phe Leu Val Ser
         115                 120                 125            
 Glu Lys His Ala Gly His Arg Ser Leu Leu Glu Ala Tyr Leu Glu Ile
     130                 135                 140                
 Leu Pro Lys Ala Tyr Thr Cys Pro Val Cys Leu Glu Pro Glu Val Val
 145                 150                 155                 160
 Asn Leu Leu Pro Lys Ser Leu Lys Ala Lys Ala Glu Glu Gln Arg Ala
                 165                 170                 175    
 His Val Gln Glu Phe Phe Ala Ser Ser Arg Asp Phe Phe Ser Ser Leu
             180                 185                 190        
 Gln Pro Leu Phe Ala Glu Ala Val Asp Ser Ile Phe Ser Tyr Ser Ala
         195                 200                 205            
 Leu Leu Trp Ala Trp Cys Thr Val Asn Thr Arg Ala Val Tyr Leu Ser
     210                 215                 220                
 Pro Gly Ser Gly Asn Ala Phe Leu Gln Ser Arg Thr Pro Val Gln Leu
 225                 230                 235                 240
 Ala Pro Tyr Leu Asp Leu Leu Asn His Ser Pro His Val Gln Val Lys
                 245                 250                 255    
 Ala Ala Phe Asn Glu Glu Thr His Ser Tyr Glu Ile Arg Thr Thr Ser
             260                 265                 270        
 Arg Trp Arg Lys His Glu Glu Val Phe Ile Cys Tyr Gly Pro His Asp
         275                 280                 285            
 Asn Gln Arg Leu Phe Leu Glu Tyr Gly Phe Val Ser Val His Asn Pro
     290                 295                 300                
 His Ala Cys Val Tyr Val Ser Arg Gly Trp Asn Gln Leu Cys Ser
 305                 310                 315                



      <210> 1629
      <211> 233
      <212> PRT
      <213> Homo sapiens


      <400> 1629
 Asn Leu Met Gly Met Gln Ile Glu Leu Phe Cys Leu Leu Lys Cys Ser
   1               5                  10                  15    
 Lys Thr Cys Gly Arg Gly Val Arg Lys Arg Glu Leu Leu Cys Lys Gly
              20                  25                  30        
 Ser Ala Ala Glu Thr Leu Pro Glu Ser Gln Cys Thr Ser Leu Pro Arg
          35                  40                  45            
 Pro Glu Leu Gln Glu Gly Cys Val Leu Gly Arg Cys Pro Lys Asn Ser
      50                  55                  60                
 Arg Leu Gln Trp Val Ala Ser Ser Trp Ser Glu Cys Ser Ala Thr Cys
  65                  70                  75                  80
 Gly Leu Gly Val Arg Lys Arg Glu Met Lys Cys Ser Glu Lys Gly Phe
                  85                  90                  95    
 Gln Gly Lys Leu Ile Thr Phe Pro Glu Arg Arg Cys Arg Asn Ile Lys
             100                 105                 110        
 Lys Pro Asn Leu Asp Leu Glu Glu Thr Cys Asn Arg Arg Ala Cys Pro
         115                 120                 125            
 Ala His Pro Val Tyr Asn Met Val Ala Gly Trp Tyr Ser Leu Pro Trp
     130                 135                 140                
 Gln Gln Cys Thr Val Thr Cys Gly Gly Gly Val Gln Thr Arg Ser Val
 145                 150                 155                 160
 His Cys Val Gln Gln Gly Arg Pro Ser Ser Ser Cys Leu Leu His Gln
                 165                 170                 175    
 Lys Pro Pro Val Leu Arg Ala Cys Asn Thr Asn Phe Cys Pro Ala Pro
             180                 185                 190        
 Glu Lys Arg Glu Asp Pro Ser Cys Val Asp Phe Phe Asn Trp Cys His
         195                 200                 205            
 Leu Val Pro Gln His Gly Val Cys Asn His Lys Phe Tyr Gly Lys Gln
     210                 215                 220                
 Cys Cys Lys Ser Cys Thr Arg Lys Ile
 225                 230            



      <210> 1630
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 1630
 Gly Ala Ile Met Gly Val Asp Ile Ala Ile Asn Lys Asp Arg Arg Val
   1               5                  10                  15    
 Arg Arg Lys Glu Pro Lys Ser Gln Asp Ile Tyr Leu Arg Leu Leu Val
              20                  25                  30        
 Lys Leu Tyr Arg Phe Leu Ala Arg Arg Thr Asn Ser Thr Phe Asn Gln
          35                  40                  45            
 Val Val Leu Lys Arg Leu Phe Met Ser Arg Thr Asn Arg Pro Pro Leu
      50                  55                  60                
 Ser Leu Ser Arg Met Ile Arg Lys Met Lys Leu Pro Gly Arg Glu Asn
  65                  70                  75                  80
 Lys Thr Ala Val Val Val Gly Thr Ile Thr Asp Asp Val Arg Val Gln
                  85                  90                  95    
 Glu Val Pro Lys Leu Lys Val Cys Ala Leu Arg Val Thr Ser Arg Ala
             100                 105                 110        
 Arg Ser Arg Ile Leu Arg Ala Gly Gly Lys Ile Leu Thr Phe Asp Gln
         115                 120                 125            
 Leu Ala Leu Asp Ser Pro Tyr Val Arg Ser Lys Gly Arg Lys Phe Glu
     130                 135                 140                
 Arg Ala Arg Gly Arg Arg Ala Ser Arg Gly Tyr Lys Asn
 145                 150                 155        



      <210> 1631
      <211> 36
      <212> PRT
      <213> Homo sapiens


      <400> 1631
 Glu Ile Ser Asn Ile Gln Gln Ala Asp Phe Pro Gly Val Leu Ala Thr
   1               5                  10                  15    
 His Pro Ala Phe Ser Arg Leu Leu Pro Cys Leu His Phe Ile Pro Lys
              20                  25                  30        
 Ser Ala Asn Gln
          35    



      <210> 1632
      <211> 240
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(240)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1632
 Met Gln Arg Gly Ala Leu Ser Pro Val Leu Met Leu Ser Ala Ala Pro
   1               5                  10                  15    
 Glu Pro Pro Pro Arg Pro Pro Pro Gly Leu Ser Pro Pro Gly Ser Gly
              20                  25                  30        
 Pro Gly Ser Gly Ser Arg His Gly Ser Ala Arg Pro Gly Pro Thr Pro
          35                  40                  45            
 Glu Pro Ser Gly Ser Leu Gly Ala Ala Leu Asp Ser Ser Leu Arg Ala
      50                  55                  60                
 Ala Val Ala Phe Lys Ala Glu Gly Gln Arg Cys Tyr Arg Glu Lys Lys
  65                  70                  75                  80
 Phe Arg Glu Ala Ile Gly Lys Tyr His Arg Ala Leu Leu Gln Leu Lys
                  85                  90                  95    
 Ala Ala Leu Gly Gly Pro Pro Xaa Arg Pro Ala Arg Pro Arg Pro Pro
             100                 105                 110        
 Gly Pro Thr Ser Ser Pro Gly Pro Ala Arg Leu Ser Glu Glu Gln Arg
         115                 120                 125            
 Arg Leu Val Glu Ser Thr Glu Val Glu Cys Tyr Asp Ser Ser Pro Ala
     130                 135                 140                
 Cys Leu Leu Gln Ser Glu Leu Val Asn Tyr Glu Arg Val Arg Glu Tyr
 145                 150                 155                 160
 Cys Leu Lys Val Leu Glu Lys Gln Gln Gly Asn Phe Arg Pro Pro Tyr
                 165                 170                 175    
 Arg Ala Gly Ile Ala Phe Tyr Pro Leu Gly Asp Tyr Ala Arg Ala Leu
             180                 185                 190        
 Arg Phe Leu Gln Glu Ala Pro Ser Arg Glu Pro Pro Asp Thr Asn Val
         195                 200                 205            
 Leu Arg Tyr Ile Gln Leu Thr Gln Leu Lys Met Asn Arg Cys Ser Leu
     210                 215                 220                
 Gln Arg Glu Asp Ser Gly Ala Gly Ser Gln Thr Arg Asp Val Ile Gly
 225                 230                 235                 240





      <210> 1633
      <211> 204
      <212> PRT
      <213> Homo sapiens


      <400> 1633
 Asp Glu Arg Gln Val Tyr Arg Tyr Leu Arg Ala Phe Leu Pro Glu Ser
   1               5                  10                  15    
 Gly Phe Thr Ile Leu Pro Cys Thr Arg Tyr Ser Met Glu Thr Asn Gly
              20                  25                  30        
 Ala Lys Ile Val Ser Thr Arg Ala Trp Lys Lys Asn Glu Lys Leu Glu
          35                  40                  45            
 Leu Leu Val Gly Cys Ile Ala Glu Leu Arg Glu Ala Asp Glu Gly Leu
      50                  55                  60                
 Leu Arg Ala Gly Glu Asn Asp Phe Ser Ile Met Tyr Ser Thr Arg Lys
  65                  70                  75                  80
 Arg Ser Ala Gln Leu Trp Leu Gly Pro Ala Ala Phe Ile Asn His Asp
                  85                  90                  95    
 Cys Lys Pro Asn Cys Lys Phe Val Pro Ala Asp Gly Asn Ala Ala Cys
             100                 105                 110        
 Val Lys Val Leu Arg Asp Ile Glu Pro Gly Asp Glu Val Thr Cys Phe
         115                 120                 125            
 Tyr Gly Glu Gly Phe Phe Gly Glu Lys Asn Glu His Cys Glu Cys His
     130                 135                 140                
 Thr Cys Glu Arg Lys Gly Glu Gly Ala Phe Arg Thr Arg Pro Arg Glu
 145                 150                 155                 160
 Pro Ala Leu Pro Pro Arg Pro Leu Asp Lys Tyr Gln Leu Arg Glu Thr
                 165                 170                 175    
 Lys Arg Arg Leu Gln Gln Gly Leu Gly Gln Trp Gln Pro Thr Gly Pro
             180                 185                 190        
 Ala Gly Pro Ser Gly Leu Arg Ala Pro Ile Pro Ala
         195                 200                



      <210> 1634
      <211> 194
      <212> PRT
      <213> Homo sapiens


      <400> 1634
 Pro Ser Arg Ser Cys Leu Gly Thr Met Arg Lys Trp Arg His Arg Glu
   1               5                  10                  15    
 Val Asn Leu Pro Glu Val Thr Gln Gln Asp Ala Val Cys Pro Ala Pro
              20                  25                  30        
 Ile Pro Ser Pro Gly Leu Ser Ala Gln Thr Gly Leu Gln Lys Ile Trp
          35                  40                  45            
 Gly Thr Ile His Cys Gln Val Cys Pro Gly Ala Pro Ala Trp Pro Gly
      50                  55                  60                
 Ser Pro Trp His Glu Glu Met Gly Leu Leu Leu Leu Val Pro Leu Leu
  65                  70                  75                  80
 Leu Leu Pro Gly Ser Tyr Gly Leu Pro Phe Tyr Asn Gly Phe Tyr Tyr
                  85                  90                  95    
 Ser Asn Ser Ala Asn Asp Gln Asn Leu Gly Asn Gly His Gly Lys Asp
             100                 105                 110        
 Leu Leu Asn Gly Val Lys Leu Val Val Glu Thr Pro Glu Glu Thr Leu
         115                 120                 125            
 Phe Thr Tyr Gln Gly Ala Ser Val Ile Leu Pro Cys Arg Tyr Arg Tyr
     130                 135                 140                
 Glu Pro Ala Leu Val Ser Pro Arg Arg Val Arg Val Lys Trp Trp Lys
 145                 150                 155                 160
 Leu Ser Glu Asn Gly Ala Pro Glu Lys Asp Val Leu Val Ala Ile Gly
                 165                 170                 175    
 Leu Arg His Arg Ser Phe Gly Asp Tyr Gln Gly Arg Val His Leu Arg
             180                 185                 190        
 Gln Asp
        



      <210> 1635
      <211> 660
      <212> PRT
      <213> Homo sapiens


      <400> 1635
 Met Gly Asp Gly Thr Ser Asp Phe Asp Pro Ile Gly Asp Ile Gly Ile
   1               5                  10                  15    
 Arg Gln Ser Asn Tyr Ser Cys Gly Gly Cys Pro Arg Ile Pro Tyr Val
              20                  25                  30        
 Trp Arg Val Thr Gly Arg Ala His Gly Thr Gln Thr Ile Val Val Phe
          35                  40                  45            
 Met Ala Lys Val Tyr Tyr Gly Asn Val Met Arg Arg Glu Lys Asp Ser
      50                  55                  60                
 Gly Gly Ala Trp Gly Asn Pro Trp Ala Gly Ile Leu Leu Pro Pro Pro
  65                  70                  75                  80
 Ser Thr Arg Asn Cys Thr Val His Ser Ser Phe Ser Asn Glu Asn Ile
                  85                  90                  95    
 Phe Pro Gln His Thr Ser Ser Cys Val Val Val His Asn Gln Tyr Ile
             100                 105                 110        
 Gly Ala Asp Phe Pro Trp Ser Asn Phe Ser Phe Val Val Glu Tyr Asn
         115                 120                 125            
 Tyr Val Glu Asp Ser Cys Trp Thr Lys His Cys Lys Glu Leu Asn Ile
     130                 135                 140                
 Pro Tyr Met Ala Phe Lys Val Ile Leu Pro Asp Thr Val Leu Glu Arg
 145                 150                 155                 160
 Ser Thr Leu Leu Asp Arg Phe Gly Gly Phe Leu Leu Glu Ile Gln Ile
                 165                 170                 175    
 Pro Tyr Val Phe Phe Ala Ser Glu Gly Leu Leu Asn Thr Pro Asp Ile
             180                 185                 190        
 Leu Gln Leu Leu Glu Ser Lys Asp Met Asp Glu Ala Gly Asn His His
         195                 200                 205            
 Ser Glu Gln Thr Val Thr Arg Thr Glu Asn Gln Thr Leu His Val Leu
     210                 215                 220                
 Thr His Arg Trp Glu Leu Asn Asn Glu Asn Thr Trp Thr Gln Asp Gly
 225                 230                 235                 240
 Glu His His Thr Pro Gly Pro Val Val Gly Trp Arg Glu Leu Ile Ile
                 245                 250                 255    
 Ala Pro Gly Val Glu Ala Thr Ala Leu Ile Ile Arg Gln Ile Ala Asp
             260                 265                 270        
 His Ser Leu Met Thr Ser Lys Arg Asp Pro His Glu Trp Leu Asp Lys
         275                 280                 285            
 Ser Trp Leu Lys Val Ser Pro Ser Glu Glu Asn Arg Asn Gln Ile Ser
     290                 295                 300                
 Thr Leu Ser Ser Gln Ser Ser Ala Ser Asp Leu Asp Ser Val Ile Gln
 305                 310                 315                 320
 Glu His Asn Glu Tyr Tyr Gln Tyr Leu Gly Leu Gly Glu Thr Val Gln
                 325                 330                 335    
 Glu Asp Lys Thr Thr Ile Leu Asn Asp Asn Ser Ser Ile Met Glu Leu
             340                 345                 350        
 Lys Glu Ile Ser Ser Phe Leu Pro Pro Val Thr Ser Tyr Asn Gln Thr
         355                 360                 365            
 Ser Tyr Trp Lys Asp Ser Ser Cys Lys Ser Asn Ile Gly Gln Asn Thr
     370                 375                 380                
 Pro Phe Leu Ile Asn Ile Glu Ser Arg Arg Pro Ala Tyr Asn Ser Phe
 385                 390                 395                 400
 Leu Asn His Ser Asp Ser Glu Ser Asp Val Phe Ser Leu Gly Leu Thr
                 405                 410                 415    
 Gln Met Asn Cys Glu Thr Ile Lys Ser Pro Thr Asp Thr Gln Lys Arg
             420                 425                 430        
 Val Ser Val Val Pro Arg Phe Ile Asn Ser Gln Lys Arg Arg Thr His
         435                 440                 445            
 Glu Ala Lys Gly Phe Ile Asn Lys Asp Val Ser Asp Pro Ile Phe Ser
     450                 455                 460                
 Leu Glu Gly Thr Gln Ser Pro Leu His Trp Asn Phe Lys Lys Asn Ile
 465                 470                 475                 480
 Trp Glu Gln Glu Asn His Pro Phe Asn Leu Gln Tyr Gly Ala Gln Gln
                 485                 490                 495    
 Thr Ala Cys Asn Lys Leu Tyr Ser Gln Lys Gly Asn Leu Phe Thr Asp
             500                 505                 510        
 Gln Gln Lys Cys Leu Ser Asp Glu Ser Glu Gly Leu Thr Cys Glu Ser
         515                 520                 525            
 Ser Lys Asp Glu Thr Phe Trp Arg Glu Leu Pro Ser Val Pro Ser Leu
     530                 535                 540                
 Asp Leu Phe Arg Ala Ser Asp Ser Asn Ala Asn Gln Lys Glu Phe Asn
 545                 550                 555                 560
 Ser Leu Tyr Phe Tyr Gln Arg Ala Gly Lys Ser Leu Gly Gln Lys Arg
                 565                 570                 575    
 His His Glu Ser Ser Phe Asn Ser Gly Asp Lys Glu Ser Leu Thr Glu
             580                 585                 590        
 Glu Lys Thr Glu Ala Gln Glu Lys Met Thr Thr Glu Asp Arg Gly Arg
         595                 600                 605            
 Gly Trp Gly Tyr Ala Thr Thr Asn Arg Arg Met Pro Arg Ile Ala Gly
     610                 615                 620                
 Asn His Gln Glu Pro Gly Glu Arg Arg Gly Thr Pro Pro Pro Ser Glu
 625                 630                 635                 640
 Ala Pro Glu Gly Ser Asn Pro Ala Asn Thr Leu Ile Leu Asp Phe Pro
                 645                 650                 655    
 Pro Pro Glu Leu
             660



      <210> 1636
      <211> 246
      <212> PRT
      <213> Homo sapiens


      <400> 1636
 Glu Trp Ala Trp Arg Ser Gln Leu Arg Ser Glu His Ser Arg Ala Asp
   1               5                  10                  15    
 Pro Thr Arg Ser Ser Cys Arg Ser Cys Gly Ala Lys Met Ser Gly Glu
              20                  25                  30        
 Glu Asn Pro Ala Ser Lys Pro Thr Pro Val Gln Asp Val Gln Gly Asp
          35                  40                  45            
 Gly Arg Trp Met Ser Leu His His Arg Phe Val Ala Asp Ser Lys Asp
      50                  55                  60                
 Lys Ser Gly Ser Lys Lys Lys Asn Pro Pro Pro Pro Glu Val Val Phe
  65                  70                  75                  80
 Ile Gly Asp Ser Leu Val Gln Leu Met His Gln Cys Glu Ile Trp Arg
                  85                  90                  95    
 Glu Leu Phe Ser Pro Leu His Ala Leu Asn Phe Gly Ile Gly Gly Asp
             100                 105                 110        
 Gly Thr Gln His Val Leu Trp Arg Leu Glu Asn Gly Glu Leu Glu His
         115                 120                 125            
 Ile Arg Pro Lys Ile Val Val Val Trp Val Gly Thr Pro Asn Asn His
     130                 135                 140                
 Gly His Thr Ala Glu Gln Gly Leu Leu Pro Arg Gly Gln His Pro Asn
 145                 150                 155                 160
 Pro Leu Arg Glu Lys Asn Arg Gln Val Asn Glu Leu Gly Thr Gly Gly
                 165                 170                 175    
 Thr Trp Leu Gly His Pro Arg Ala His Phe Leu Asp Ala Asp Pro Gly
             180                 185                 190        
 Phe Val His Ser Asp Gly Thr Ile Ser His His Asp Met Tyr Asp Tyr
         195                 200                 205            
 Leu His Leu Ser Arg Leu Gly Tyr Thr Pro Val Cys Arg Ala Leu His
     210                 215                 220                
 Ser Leu Leu Leu Arg Leu Leu Ala Gln Asp Gln Gly Gln Gly Ala Pro
 225                 230                 235                 240
 Leu Leu Glu Pro Ala Pro
                 245    



      <210> 1637
      <211> 292
      <212> PRT
      <213> Homo sapiens


      <400> 1637
 Arg Asn Ser Asp Met Ile Leu Ser Ala Ser Arg Asp Lys Thr Ile Ile
   1               5                  10                  15    
 Met Trp Lys Leu Thr Arg Asp Glu Thr Asn Tyr Gly Ile Pro Gln Arg
              20                  25                  30        
 Ala Leu Arg Gly His Ser His Phe Val Ser Asp Val Val Ile Ser Ser
          35                  40                  45            
 Asp Gly Gln Phe Ala Leu Ser Gly Ser Trp Asp Gly Thr Leu Arg Leu
      50                  55                  60                
 Trp Asp Leu Thr Thr Gly Thr Thr Thr Arg Arg Phe Val Gly His Thr
  65                  70                  75                  80
 Lys Asp Val Leu Ser Val Ala Phe Ser Ser Asp Asn Arg Gln Ile Val
                  85                  90                  95    
 Ser Gly Ser Arg Asp Lys Thr Ile Lys Leu Trp Asn Thr Leu Gly Val
             100                 105                 110        
 Cys Lys Tyr Thr Val Gln Asp Glu Ser His Ser Glu Trp Val Ser Cys
         115                 120                 125            
 Val Arg Phe Ser Pro Asn Ser Ser Asn Pro Ile Ile Val Ser Cys Gly
     130                 135                 140                
 Trp Asp Lys Leu Val Lys Val Trp Asn Leu Ala Asn Cys Lys Leu Lys
 145                 150                 155                 160
 Thr Asn His Ile Gly His Thr Gly Tyr Leu Asn Thr Val Thr Val Ser
                 165                 170                 175    
 Pro Asp Gly Ser Leu Cys Ala Ser Gly Gly Lys Asp Gly Gln Ala Met
             180                 185                 190        
 Leu Trp Asp Leu Asn Glu Gly Lys His Leu Tyr Thr Leu Asp Gly Gly
         195                 200                 205            
 Asp Ile Ile Asn Ala Leu Cys Phe Ser Pro Asn Arg Tyr Trp Leu Cys
     210                 215                 220                
 Ala Ala Thr Gly Pro Ser Ile Lys Ile Trp Asp Leu Glu Gly Lys Ile
 225                 230                 235                 240
 Ile Val Asp Glu Leu Lys Gln Glu Val Ile Ser Thr Ser Ser Lys Ala
                 245                 250                 255    
 Glu Pro Pro Gln Cys Thr Ser Leu Ala Trp Ser Ala Asp Gly Gln Thr
             260                 265                 270        
 Leu Phe Ala Gly Tyr Thr Asp Asn Leu Val Arg Val Trp Gln Val Thr
         275                 280                 285            
 Ile Gly Thr Arg
     290        



      <210> 1638
      <211> 292
      <212> PRT
      <213> Homo sapiens


      <400> 1638
 Arg Asn Ser Asp Met Ile Leu Ser Ala Ser Arg Asp Lys Thr Ile Ile
   1               5                  10                  15    
 Met Trp Lys Leu Thr Arg Asp Glu Thr Asn Tyr Gly Ile Pro Gln Arg
              20                  25                  30        
 Ala Leu Arg Gly His Ser His Phe Val Ser Asp Val Val Ile Ser Ser
          35                  40                  45            
 Asp Gly Gln Phe Ala Leu Ser Gly Ser Trp Asp Gly Thr Leu Arg Leu
      50                  55                  60                
 Trp Asp Leu Thr Thr Gly Thr Thr Thr Arg Arg Phe Val Gly His Thr
  65                  70                  75                  80
 Lys Asp Val Leu Ser Val Ala Phe Ser Ser Asp Asn Arg Gln Ile Val
                  85                  90                  95    
 Ser Gly Ser Arg Asp Lys Thr Ile Lys Leu Trp Asn Thr Leu Gly Val
             100                 105                 110        
 Cys Lys Tyr Thr Val Gln Asp Glu Ser His Ser Glu Trp Val Ser Cys
         115                 120                 125            
 Val Arg Phe Ser Pro Asn Ser Ser Asn Pro Ile Ile Val Ser Cys Gly
     130                 135                 140                
 Trp Asp Lys Leu Val Lys Val Trp Asn Leu Ala Asn Cys Lys Leu Lys
 145                 150                 155                 160
 Thr Asn His Ile Gly His Thr Gly Tyr Leu Asn Thr Val Thr Val Ser
                 165                 170                 175    
 Pro Asp Gly Ser Leu Cys Ala Ser Gly Gly Lys Asp Gly Gln Ala Met
             180                 185                 190        
 Leu Trp Asp Leu Asn Glu Gly Lys His Leu Tyr Thr Leu Asp Gly Gly
         195                 200                 205            
 Asp Ile Ile Asn Ala Leu Cys Phe Ser Pro Asn Arg Tyr Trp Leu Cys
     210                 215                 220                
 Ala Ala Thr Gly Pro Ser Ile Lys Ile Trp Asp Leu Glu Gly Lys Ile
 225                 230                 235                 240
 Ile Val Asp Glu Leu Lys Gln Glu Val Ile Ser Thr Ser Ser Lys Ala
                 245                 250                 255    
 Glu Pro Pro Gln Cys Thr Ser Leu Ala Trp Ser Ala Asp Gly Gln Thr
             260                 265                 270        
 Leu Phe Ala Gly Tyr Thr Asp Asn Leu Val Arg Val Trp Gln Val Thr
         275                 280                 285            
 Ile Gly Thr Arg
     290        



      <210> 1639
      <211> 770
      <212> PRT
      <213> Homo sapiens


      <400> 1639
 Ala Lys Thr Asp Gly Thr Ser Tyr Ala Asp Asp Ser Lys Ser Asn Ser
   1               5                  10                  15    
 Pro Asp Ser Thr Pro Asn His Pro Ser Gln Thr Thr Pro Ala Gln Lys
              20                  25                  30        
 Lys Thr Pro Ser Ser Ser Ser Arg Gln Lys Asp Lys Val Asn Lys Arg
          35                  40                  45            
 Asn Glu Arg Gly Glu Thr Pro Leu His Met Ala Ala Ile Arg Gly Asp
      50                  55                  60                
 Val Lys Gln Val Lys Glu Leu Ile Ser Leu Gly Ala Asn Val Asn Val
  65                  70                  75                  80
 Lys Asp Phe Ala Gly Trp Thr Pro Leu His Glu Ala Cys Asn Val Gly
                  85                  90                  95    
 Tyr Tyr Asp Val Ala Lys Ile Leu Ile Ala Ala Gly Ala Asp Val Asn
             100                 105                 110        
 Thr Gln Gly Leu Asp Asp Asp Thr Pro Leu His Asp Ser Ala Ser Ser
         115                 120                 125            
 Gly His Arg Asp Ile Val Lys Leu Leu Leu Arg His Gly Gly Asn Pro
     130                 135                 140                
 Phe Gln Ala Asn Lys His Gly Glu Arg Pro Val Asp Val Ala Glu Thr
 145                 150                 155                 160
 Glu Glu Leu Glu Leu Leu Leu Lys Arg Glu Val Pro Leu Ser Asp Asp
                 165                 170                 175    
 Asp Glu Ser Tyr Thr Asp Ser Glu Glu Ala Gln Ser Val Asn Pro Ser
             180                 185                 190        
 Ser Val Asp Glu Asn Ile Asp Ser Glu Thr Glu Lys Asp Ser Leu Ile
         195                 200                 205            
 Cys Glu Ser Lys Gln Ile Leu Pro Ser Lys Thr Pro Leu Pro Ser Ala
     210                 215                 220                
 Leu Asp Glu Tyr Glu Phe Lys Asp Asp Asp Asp Glu Glu Ile Asn Lys
 225                 230                 235                 240
 Met Ile Asp Asp Arg His Ile Leu Arg Lys Glu Gln Arg Lys Glu Asn
                 245                 250                 255    
 Glu Pro Glu Ala Glu Lys Thr His Leu Phe Ala Lys Gln Glu Lys Ala
             260                 265                 270        
 Phe Tyr Pro Lys Ser Phe Lys Ser Lys Lys Gln Lys Pro Ser Arg Val
         275                 280                 285            
 Leu Tyr Ser Ser Thr Glu Ser Ser Asp Glu Glu Ala Leu Gln Asn Lys
     290                 295                 300                
 Lys Ile Ser Thr Ser Cys Ser Val Ile Pro Glu Thr Ser Asn Ser Asp
 305                 310                 315                 320
 Met Gln Thr Lys Lys Glu Tyr Val Val Ser Gly Glu His Lys Gln Lys
                 325                 330                 335    
 Gly Lys Val Lys Arg Lys Leu Lys Asn Gln Asn Lys Asn Lys Glu Asn
             340                 345                 350        
 Gln Glu Leu Lys Gln Glu Lys Glu Gly Lys Glu Asn Thr Arg Ile Thr
         355                 360                 365            
 Asn Leu Thr Val Asn Thr Gly Leu Asp Cys Ser Glu Lys Thr Arg Glu
     370                 375                 380                
 Glu Gly Asn Phe Arg Lys Ser Phe Ser Pro Lys Asp Asp Thr Ser Leu
 385                 390                 395                 400
 His Leu Phe His Ile Ser Thr Gly Lys Ser Pro Lys His Ser Cys Gly
                 405                 410                 415    
 Leu Ser Glu Lys Gln Ser Thr Pro Leu Lys Gln Glu His Thr Lys Thr
             420                 425                 430        
 Cys Leu Ser Pro Gly Ser Ser Glu Met Ser Leu Gln Pro Asp Leu Val
         435                 440                 445            
 Arg Tyr Asp Asn Thr Glu Ser Glu Phe Leu Pro Glu Ser Ser Ser Val
     450                 455                 460                
 Lys Ser Cys Lys His Lys Glu Lys Ser Lys His Gln Lys Asp Phe His
 465                 470                 475                 480
 Leu Glu Phe Gly Glu Lys Ser Asn Ala Lys Ile Lys Asp Glu Asp His
                 485                 490                 495    
 Ser Pro Thr Phe Glu Asn Ser Asp Cys Thr Leu Lys Lys Met Asp Lys
             500                 505                 510        
 Glu Gly Lys Thr Leu Lys Lys His Lys Leu Lys His Lys Glu Arg Glu
         515                 520                 525            
 Lys Glu Lys His Lys Lys Glu Ile Glu Gly Glu Lys Glu Lys Tyr Lys
     530                 535                 540                
 Thr Lys Asp Ser Ala Lys Glu Leu Gln Arg Ser Val Glu Phe Asp Arg
 545                 550                 555                 560
 Glu Phe Trp Lys Glu Asn Phe Phe Lys Ser Asp Glu Thr Glu Asp Leu
                 565                 570                 575    
 Phe Leu Asn Met Glu His Glu Ser Leu Thr Leu Glu Lys Lys Ser Lys
             580                 585                 590        
 Leu Glu Lys Asn Ile Lys Asp Asp Lys Ser Thr Lys Glu Lys His Val
         595                 600                 605            
 Ser Lys Glu Arg Asn Phe Lys Glu Glu Arg Asp Lys Ile Lys Lys Glu
     610                 615                 620                
 Ser Glu Lys Ser Phe Arg Glu Glu Lys Ile Lys Asp Leu Lys Glu Glu
 625                 630                 635                 640
 Arg Glu Asn Ile Pro Thr Asp Lys Asp Ser Glu Phe Thr Ser Leu Gly
                 645                 650                 655    
 Met Ser Ala Ile Glu Glu Ser Ile Gly Leu His Leu Val Glu Lys Glu
             660                 665                 670        
 Ile Asp Ile Glu Lys Gln Glu Lys His Ile Lys Glu Ser Lys Glu Lys
         675                 680                 685            
 Pro Glu Lys Arg Ser Gln Ile Lys Glu Lys Asp Ile Glu Lys Met Glu
     690                 695                 700                
 Arg Lys Thr Phe Glu Lys Glu Lys Lys Ile Lys His Glu His Lys Ser
 705                 710                 715                 720
 Glu Lys Asp Lys Leu Asp Leu Ser Glu Cys Val Asp Lys Lys Lys Lys
                 725                 730                 735    
 Lys Asp Lys Leu Tyr Ser His His Thr Glu Lys Cys His Lys Glu Gly
             740                 745                 750        
 Glu Lys Ser Lys Asn Thr Ala Ala Ile Lys Lys Thr Asp Asp Arg Arg
         755                 760                 765            
 Glu Lys
     770



      <210> 1640
      <211> 175
      <212> PRT
      <213> Homo sapiens


      <400> 1640
 Ser Gly Gln Cys Leu Val Trp Val Gln Cys Ser Phe Pro Asn Cys Gly
   1               5                  10                  15    
 Lys Trp Arg Arg Leu Cys Gly Asn Ile Asp Pro Ser Val Leu Pro Asp
              20                  25                  30        
 Asn Trp Ser Cys Asp Gln Asn Thr Ala Asp Val Gln Tyr Asn Arg Cys
          35                  40                  45            
 Asp Ile Pro Glu Glu Thr Trp Thr Gly Leu Glu Ser Asp Val Ala Tyr
      50                  55                  60                
 Ala Ser Tyr Ile Pro Gly Ser Ile Ile Trp Ala Lys Gln Tyr Gly Tyr
  65                  70                  75                  80
 Pro Trp Trp Pro Gly Met Ile Glu Ser Asp Pro Asp Leu Gly Glu Tyr
                  85                  90                  95    
 Phe Leu Phe Thr Ser His Leu Asp Ser Leu Pro Ser Lys Tyr His Val
             100                 105                 110        
 Thr Phe Phe Gly Glu Thr Val Ser Arg Ala Trp Ile Pro Val Asn Met
         115                 120                 125            
 Leu Lys Asn Phe Gln Glu Leu Ser Leu Glu Leu Ser Val Met Lys Lys
     130                 135                 140                
 Arg Arg Asn Asp Cys Ser Gln Lys Leu Gly Val Ala Leu Met Met Ala
 145                 150                 155                 160
 Gln Glu Ala Glu Gln Ile Ser Ile Gln Glu Arg Val Asn Leu Phe
                 165                 170                 175



      <210> 1641
      <211> 138
      <212> PRT
      <213> Homo sapiens


      <400> 1641
 His Ser Arg Ser Arg Ala Pro Val Ser Ser Leu Arg Gly Asn Arg Glu
   1               5                  10                  15    
 Cys Arg Gly Asn Gly Lys Thr Val Cys Lys Cys Gly Ala Pro Asn Cys
              20                  25                  30        
 Ser Gly Phe Leu Gly Val Arg Pro Lys Asn Gln Pro Ile Ala Thr Glu
          35                  40                  45            
 Glu Lys Ser Lys Lys Phe Lys Lys Lys Gln Gln Gly Lys Arg Arg Thr
      50                  55                  60                
 Gln Gly Glu Ile Thr Lys Glu Arg Glu Asp Glu Cys Phe Ser Cys Gly
  65                  70                  75                  80
 Asp Ala Gly Gln Leu Val Ser Cys Lys Lys Pro Gly Cys Pro Lys Val
                  85                  90                  95    
 Tyr His Ala Asp Cys Leu Asn Leu Thr Lys Arg Pro Thr Leu Gly Leu
             100                 105                 110        
 Leu Arg Ala Val Leu Ser Leu Ser Lys Ala Pro Leu His Leu Val His
         115                 120                 125            
 Ala Pro Val Val Arg Ile Pro His Cys Ser
     130                 135            



      <210> 1642
      <211> 342
      <212> PRT
      <213> Homo sapiens


      <400> 1642
 Gln Glu Arg Arg Lys Glu Ala Glu Arg Ile Ala Arg Glu Arg Glu Glu
   1               5                  10                  15    
 Leu Arg Arg Gln Gln Gln Gln Leu Arg Tyr Glu Gln Glu Lys Arg Asn
              20                  25                  30        
 Ser Leu Lys Arg Pro Arg Asp Val Asp His Arg Arg Asp Asp Pro Tyr
          35                  40                  45            
 Trp Ser Glu Asn Lys Lys Leu Ser Leu Asp Thr Asp Ala Arg Phe Gly
      50                  55                  60                
 His Gly Ser Asp Tyr Ser Arg Gln Gln Asn Arg Phe Asn Asp Phe Asp
  65                  70                  75                  80
 His Arg Glu Arg Gly Arg Phe Pro Glu Ser Ser Ala Val Gln Ser Ser
                  85                  90                  95    
 Ser Phe Glu Arg Arg Asp Arg Phe Val Gly Gln Ser Glu Gly Lys Lys
             100                 105                 110        
 Ala Arg Pro Thr Ala Arg Arg Glu Asp Pro Ser Phe Glu Arg Tyr Pro
         115                 120                 125            
 Lys Asn Phe Ser Asp Ser Arg Arg Asn Glu Pro Pro Pro Pro Arg Asn
     130                 135                 140                
 Glu Leu Arg Glu Ser Asp Arg Arg Glu Val Arg Gly Glu Arg Asp Glu
 145                 150                 155                 160
 Arg Arg Thr Val Ile Ile His Asp Arg Pro Asp Ile Thr His Pro Arg
                 165                 170                 175    
 His Pro Arg Glu Ala Gly Pro Asn Pro Ser Arg Pro Thr Ser Trp Lys
             180                 185                 190        
 Ser Glu Gly Ser Met Ser Thr Asp Lys Arg Glu Thr Arg Val Glu Arg
         195                 200                 205            
 Pro Glu Arg Ser Gly Arg Glu Val Ser Gly His Ser Val Arg Gly Ala
     210                 215                 220                
 Pro Pro Gly Asn Arg Ser Ser Ala Ser Gly Tyr Gly Ser Arg Glu Gly
 225                 230                 235                 240
 Asp Arg Gly Val Ile Thr Asp Arg Gly Gly Gly Ser Gln His Tyr Pro
                 245                 250                 255    
 Glu Glu Arg His Val Val Glu Arg His Gly Arg Asp Thr Ser Gly Pro
             260                 265                 270        
 Arg Lys Glu Trp His Gly Pro Pro Ser Gln Gly Pro Ser Tyr His Asp
         275                 280                 285            
 Thr Arg Arg Met Gly Asp Gly Arg Ala Gly Ala Gly Met Ile Thr Gln
     290                 295                 300                
 His Ser Ser Asn Ala Ser Pro Ile Asn Arg Ile Val Gln Ile Ser Gly
 305                 310                 315                 320
 Asn Ser Met Pro Arg Gly Ser Gly Ser Gly Phe Lys Pro Phe Lys Gly
                 325                 330                 335    
 Gly Pro Pro Arg Arg Phe
             340        



      <210> 1643
      <211> 148
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(148)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1643
 Pro Ala Thr Glu Leu Pro Gly Leu Pro Thr Arg Pro Gly Met Leu Cys
   1               5                  10                  15    
 Ile Trp Arg Gly Ala Pro Asp Trp Pro Glu Gly Pro Pro Ser Ser Gly
              20                  25                  30        
 Glu Leu Ser Ser Ile Gln Pro Thr Gln Gly Leu His Asn Cys Phe Gln
          35                  40                  45            
 Pro Asp Gly Ala Arg Pro Ala Ala Pro Gly Pro Val Pro Gly Gln Leu
      50                  55                  60                
 Gly Ala Leu Pro Trp Ser Cys Arg Pro Pro Ala Glu Pro Thr Leu Phe
  65                  70                  75                  80
 Met Glu Ser Leu Val Gln Trp Pro Pro Gly Asp Gly Ile Arg Gln Xaa
                  85                  90                  95    
 Cys Glu Asp Ala Ala Glu Leu Arg Glu Pro Gly Val Gln Arg His Gln
             100                 105                 110        
 Gly Ser Pro Gly Xaa Val Arg Thr Leu Pro Pro Leu Arg Gly Pro Ser
         115                 120                 125            
 Gln Val Pro Ala Gly Ser Ser Ser Ser Ala Ser Pro Arg Ser Ile Pro
     130                 135                 140                
 Gly Ser Arg Gly
 145            



      <210> 1644
      <211> 407
      <212> PRT
      <213> Homo sapiens


      <400> 1644
 Asn Ile Leu Glu Ser Thr Met Asn Gly Gln Leu Asp Leu Ser Gly Lys
   1               5                  10                  15    
 Leu Ile Ile Lys Ala Gln Leu Gly Glu Asp Ile Arg Arg Ile Pro Ile
              20                  25                  30        
 His Asn Glu Asp Ile Thr Tyr Asp Glu Leu Val Leu Met Met Gln Arg
          35                  40                  45            
 Val Phe Arg Gly Lys Leu Leu Ser Asn Asp Glu Val Thr Ile Lys Tyr
      50                  55                  60                
 Lys Asp Glu Asp Gly Asp Leu Ile Thr Ile Phe Asp Ser Ser Asp Leu
  65                  70                  75                  80
 Ser Phe Ala Ile Gln Cys Ser Arg Ile Leu Lys Leu Thr Leu Phe Val
                  85                  90                  95    
 Asn Gly Gln Pro Arg Pro Leu Glu Ser Ser Gln Val Lys Tyr Leu Arg
             100                 105                 110        
 Arg Glu Leu Ile Glu Leu Arg Asn Lys Val Asn Arg Leu Leu Asp Ser
         115                 120                 125            
 Leu Glu Pro Pro Gly Glu Pro Gly Pro Ser Thr Asn Ile Pro Glu Asn
     130                 135                 140                
 Asp Thr Val Asp Gly Arg Glu Glu Lys Ser Ala Ser Asp Ser Ser Gly
 145                 150                 155                 160
 Lys Gln Ser Thr Gln Val Met Ala Ala Ser Met Ser Ala Phe Asp Pro
                 165                 170                 175    
 Leu Lys Asn Gln Asp Glu Ile Asn Lys Asn Val Met Ser Ala Phe Gly
             180                 185                 190        
 Leu Thr Asp Asp Gln Val Ser Gly Pro Pro Ser Ala Pro Ala Glu Asp
         195                 200                 205            
 Arg Ser Gly Thr Pro Asp Ser Ile Ala Ser Ser Ser Ser Ala Ala His
     210                 215                 220                
 Pro Pro Gly Val Gln Pro Gln Gln Pro Pro Tyr Thr Gly Ala Gln Thr
 225                 230                 235                 240
 Gln Ala Gly His Gln Ile Glu Gly Gln Met Tyr Gln Gln Tyr Gln Gln
                 245                 250                 255    
 Gln Ala Gly Tyr Gly Ala Gln Gln Pro Gln Ala Pro Pro Gln Gln Pro
             260                 265                 270        
 Gln Gln Tyr Gly Ile Gln Tyr Ser Ala Ser Tyr Ser Gln Gln Thr Gly
         275                 280                 285            
 Pro Gln Gln Pro Gln Gln Phe Gln Gly Tyr Gly Gln Gln Pro Thr Ser
     290                 295                 300                
 Gln Ala Pro Ala Pro Ala Phe Ser Gly Gln Pro Gln Gln Leu Pro Ala
 305                 310                 315                 320
 Gln Pro Pro Gln Gln Tyr Gln Ala Ser Asn Tyr Pro Ala Gln Thr Tyr
                 325                 330                 335    
 Thr Ala Gln Thr Ser Gln Pro Thr Asn Tyr Thr Val Ala Pro Ala Ser
             340                 345                 350        
 Gln Pro Gly Met Ala Pro Ser Gln Pro Gly Ala Tyr Gln Pro Arg Pro
         355                 360                 365            
 Gly Phe Thr Ser Leu Pro Gly Ser Thr Met Thr Pro Pro Pro Ser Gly
     370                 375                 380                
 Pro Asn Pro Tyr Ala Arg Asn Arg Pro Pro Phe Gly Gln Gly Tyr Thr
 385                 390                 395                 400
 Gln Pro Gly Pro Gly Tyr Arg
                 405        



      <210> 1645
      <211> 468
      <212> PRT
      <213> Homo sapiens


      <400> 1645
 Arg Arg Arg Arg His Ala His Ile Pro Ala Arg Arg Cys Pro Pro Ser
   1               5                  10                  15    
 Ser Cys Ser Gln Thr Glu Ala Gln Pro Pro Ser Pro Val Ser Ile Thr
              20                  25                  30        
 Ser Ala Ala Ser Met Ser Asp Lys Leu Pro Tyr Lys Val Ala Asp Ile
          35                  40                  45            
 Gly Leu Ala Ala Trp Gly Arg Lys Ala Leu Asp Ile Ala Glu Asn Glu
      50                  55                  60                
 Met Pro Gly Leu Met Arg Met Arg Glu Arg Tyr Ser Ala Ser Lys Pro
  65                  70                  75                  80
 Leu Lys Gly Ala Arg Ile Ala Gly Cys Leu His Met Thr Val Glu Thr
                  85                  90                  95    
 Ala Val Leu Ile Glu Thr Leu Val Thr Leu Gly Ala Glu Val Gln Trp
             100                 105                 110        
 Ser Ser Cys Asn Ile Phe Ser Thr Gln Asp His Ala Ala Ala Ala Ile
         115                 120                 125            
 Ala Lys Ala Gly Ile Pro Val Tyr Ala Trp Lys Gly Glu Thr Asp Glu
     130                 135                 140                
 Glu Tyr Leu Trp Cys Ile Glu Gln Thr Leu Tyr Phe Lys Asp Gly Pro
 145                 150                 155                 160
 Leu Asn Met Ile Leu Asp Asp Gly Gly Asp Leu Thr Asn Leu Ile His
                 165                 170                 175    
 Thr Lys Tyr Pro Gln Leu Leu Pro Gly Ile Arg Gly Ile Ser Glu Glu
             180                 185                 190        
 Thr Thr Thr Gly Val His Asn Leu Tyr Lys Met Met Ala Asn Gly Ile
         195                 200                 205            
 Leu Lys Val Pro Ala Ile Asn Val Asn Asp Ser Val Thr Lys Ser Lys
     210                 215                 220                
 Phe Asp Asn Leu Tyr Gly Cys Arg Glu Ser Leu Ile Asp Gly Ile Lys
 225                 230                 235                 240
 Arg Ala Thr Asp Val Met Ile Ala Gly Lys Val Ala Val Val Ala Gly
                 245                 250                 255    
 Tyr Gly Asp Val Gly Lys Gly Cys Ala Gln Ala Leu Arg Gly Phe Gly
             260                 265                 270        
 Ala Arg Val Ile Ile Thr Glu Ile Asp Pro Ile Asn Ala Leu Gln Ala
         275                 280                 285            
 Ala Met Glu Gly Tyr Glu Val Thr Thr Met Asp Glu Ala Cys Gln Glu
     290                 295                 300                
 Gly Asn Ile Phe Val Thr Thr Thr Gly Cys Ile Asp Ile Ile Leu Gly
 305                 310                 315                 320
 Arg His Phe Glu Gln Met Lys Asp Asp Ala Ile Val Cys Asn Ile Gly
                 325                 330                 335    
 His Phe Asp Val Glu Ile Asp Val Lys Trp Leu Asn Glu Asn Ala Val
             340                 345                 350        
 Glu Lys Val Asn Ile Lys Pro Gln Val Asp Arg Tyr Arg Leu Lys Asn
         355                 360                 365            
 Gly Arg Arg Ile Ile Leu Leu Ala Glu Gly Arg Leu Val Asn Leu Gly
     370                 375                 380                
 Cys Ala Met Gly His Pro Ser Phe Val Met Ser Asn Ser Phe Thr Asn
 385                 390                 395                 400
 Gln Val Met Ala Gln Ile Glu Leu Trp Thr His Pro Asp Lys Tyr Pro
                 405                 410                 415    
 Val Gly Val His Phe Leu Pro Lys Lys Leu Asp Glu Ala Val Ala Glu
             420                 425                 430        
 Ala His Leu Gly Lys Leu Asn Val Lys Leu Thr Lys Leu Thr Glu Lys
         435                 440                 445            
 Gln Ala Gln Tyr Leu Gly Met Ser Cys Asp Gly Pro Phe Lys Pro Asp
     450                 455                 460                
 His Tyr Arg Tyr
 465            



      <210> 1646
      <211> 330
      <212> PRT
      <213> Homo sapiens


      <400> 1646
 Asp Ala Trp Ala Glu Thr Arg His Trp Thr Ala Leu Thr Phe Ala Val
   1               5                  10                  15    
 Leu His Gly His Ile Pro Val Val Gln Leu Leu Leu Asp Ala Gly Ala
              20                  25                  30        
 Lys Val Glu Gly Ser Val Glu His Gly Glu Glu Asn Tyr Ser Glu Thr
          35                  40                  45            
 Pro Leu Gln Leu Ala Ala Ala Val Gly Asn Phe Glu Leu Val Ser Leu
      50                  55                  60                
 Leu Leu Glu Arg Gly Ala Asp Pro Leu Ile Gly Thr Met Tyr Arg Asn
  65                  70                  75                  80
 Gly Ile Ser Thr Thr Pro Gln Gly Asp Met Asn Ser Phe Ser Gln Ala
                  85                  90                  95    
 Ala Ala His Gly His Arg Asn Val Phe Arg Lys Leu Leu Ala Gln Pro
             100                 105                 110        
 Glu Lys Glu Lys Ser Asp Ile Leu Ser Leu Glu Glu Ile Leu Ala Glu
         115                 120                 125            
 Gly Thr Asp Leu Ala Glu Thr Ala Pro Pro Pro Leu Cys Ala Ser Arg
     130                 135                 140                
 Asn Ser Lys Ala Lys Leu Arg Ala Leu Arg Glu Ala Met Tyr His Ser
 145                 150                 155                 160
 Ala Glu His Gly Tyr Val Asp Val Thr Ile Asp Ile Arg Ser Ile Gly
                 165                 170                 175    
 Val Pro Trp Thr Leu His Thr Trp Leu Glu Ser Leu Arg Ile Ala Phe
             180                 185                 190        
 Gln Gln His Arg Arg Pro Leu Ile Gln Cys Leu Leu Lys Glu Phe Lys
         195                 200                 205            
 Thr Ile Gln Glu Glu Glu Tyr Thr Glu Glu Leu Val Thr Gln Gly Leu
     210                 215                 220                
 Pro Leu Met Phe Glu Ile Leu Lys Ala Ser Lys Asn Glu Val Ile Ser
 225                 230                 235                 240
 Gln Gln Leu Cys Val Ile Phe Thr His Cys Tyr Gly Pro Tyr Pro Ile
                 245                 250                 255    
 Pro Lys Leu Thr Glu Ile Lys Arg Lys Gln Thr Ser Arg Leu Asp Pro
             260                 265                 270        
 His Phe Leu Asn Asn Lys Glu Met Ser Asp Val Thr Phe Leu Val Glu
         275                 280                 285            
 Gly Arg Pro Phe Tyr Ala His Lys Val Leu Leu Phe Thr Ala Ser Pro
     290                 295                 300                
 Arg Val Lys Ala Leu Leu Ser Ser Lys Pro Thr Asn Asp Gly Thr Cys
 305                 310                 315                 320
 Ile Glu Ile Gly Tyr Val Lys Tyr Ser Ile
                 325                 330



      <210> 1647
      <211> 740
      <212> PRT
      <213> Homo sapiens


      <400> 1647
 Met Thr Ser Val Ile Arg Asp Thr Ile Met Thr Arg Tyr Gly Pro Ile
   1               5                  10                  15    
 Leu Pro Thr His Gln Pro His Pro Ile Gln Gln Gly Ala Cys Ser Arg
              20                  25                  30        
 Asp Lys Arg Ile Trp Ser Trp Glu Gln Lys Gln Glu Thr Gly Ser Gln
          35                  40                  45            
 Leu Gly Trp Glu Cys Lys Leu Val Gln Leu Leu Trp Lys Thr Val Trp
      50                  55                  60                
 Arg Phe Leu Lys Glu Leu Lys Val Glu Leu Pro Phe Asp Pro Ala Thr
  65                  70                  75                  80
 Pro Leu Leu Ser Ile Tyr Pro Lys Glu Lys Lys Ser Leu Tyr Glu Lys
                  85                  90                  95    
 Asp Thr Arg Thr Cys Met Phe Ile Ala Ala Gln Phe Thr Ile Ala Lys
             100                 105                 110        
 Ile Trp His Gln Pro Lys Cys Pro Pro Thr Asn Lys Trp Ile Lys Lys
         115                 120                 125            
 Met Trp Tyr Thr Tyr Ile Lys Lys Tyr Tyr Ser Thr Ile Lys Arg Asn
     130                 135                 140                
 Glu Ile Met Tyr Phe Ala Ala Thr Trp Met Glu Leu Glu Ala Ile Ile
 145                 150                 155                 160
 Leu Ser Glu His Pro Leu Val Leu Ile His Pro Gln Ile Phe Arg Pro
                 165                 170                 175    
 Asp Ala Pro Leu Ala Lys Pro Trp Ser Leu Pro Phe Ile Ser Ser Pro
             180                 185                 190        
 Leu Gln Pro Ser Glu Lys Ser Arg Leu Lys Thr Thr His Trp Gly Gly
         195                 200                 205            
 Gly Gly Ser Glu Asp Ser Gly Arg Gln Gly Ala Phe Val Ala Phe Pro
     210                 215                 220                
 Glu Arg Ser Gly Val Cys Glu Val Val Ser Ile Met Phe Ser Phe Asn
 225                 230                 235                 240
 Met Phe Asn His Leu Ile Pro Arg Val Phe Gln Asn Arg Phe Ser Thr
                 245                 250                 255    
 His Tyr Arg Cys Phe Ser Val Ser Thr Leu Ala Gly Pro Asn Asp Lys
             260                 265                 270        
 Ser Asp Val Glu Lys Gly Gly Lys Ile Ile Met Leu Pro Ser Ala Leu
         275                 280                 285            
 Asp Gln Leu Ser Gln Leu Asn Ile Thr Tyr Pro Met Leu Phe Lys Leu
     290                 295                 300                
 Thr Ser Lys Asn Leu Asp Arg Met Thr His Cys Gly Val Leu Glu Phe
 305                 310                 315                 320
 Val Ala Asp Glu Gly Ile Cys Tyr Leu Pro His Trp Met Met Gln Asn
                 325                 330                 335    
 Leu Leu Leu Glu Glu Gly Ser Leu Pro Gln Ser Pro Asp Ile Leu Asp
             340                 345                 350        
 Ile Thr Asn Pro Lys Ala Val Leu Asp Asn Ala Leu Arg Asn Phe Ala
         355                 360                 365            
 Cys Leu Thr Thr Gly Asn Val Thr Ala Ile Asn Cys Asn Glu Lys Ile
     370                 375                 380                
 Tyr Glu Leu Glu Leu Arg Val Met Glu Thr Lys Pro Asn Lys Ala Val
 385                 390                 395                 400
 Ser Ile Thr Glu Cys Asp Thr Asn Val Asp Ser Asp Ala Pro Leu Gly
                 405                 410                 415    
 Tyr Lys Glu Pro Glu Arg Gln Val Gln His Glu Glu Leu Thr Glu Gly
             420                 425                 430        
 Glu Ala Asp His Ser Gly Tyr Ala Gly Glu Leu Gly Phe Arg Ala Phe
         435                 440                 445            
 Ser Gly Ser Gly Asn Arg Leu Asp Gly Lys Lys Glu Ser Pro Ser Pro
     450                 455                 460                
 Ile Lys Pro Gly Asp Ile Lys Arg Gly Ile Pro Asn His Glu Phe Lys
 465                 470                 475                 480
 Leu Asp Ser Leu Asn Ser Cys Met Ser Pro Ala Arg Phe Leu Glu Ala
                 485                 490                 495    
 Ser Glu Ile Val Phe Gly Asp Gln Glu Ala Ile Gly Ser Thr Phe Met
             500                 505                 510        
 Gly Thr His Pro Ile Pro Glu Leu Thr Leu Thr Phe Asn Trp Trp Arg
         515                 520                 525            
 Arg Val Ser Ile His Phe Pro Glu Ser Ser Asn Lys Arg Glu Glu Cys
     530                 535                 540                
 Gly Val Leu His Leu Asp Ile His Gly Lys Lys Glu Asp Met Arg Ile
 545                 550                 555                 560
 Thr Gln Gln Ser Ser Gln Leu Tyr Leu Trp Asp Met Gly Gly Phe Thr
                 565                 570                 575    
 Ile Phe Lys Asn Leu Trp Met Ser Leu Ile Pro Arg Gly Asn Lys Arg
             580                 585                 590        
 Ser Pro Lys Arg Val Thr Glu Thr Ile Leu Arg Asp Phe Lys Gln Lys
         595                 600                 605            
 Gln Ser Ser Lys Ile Gln Glu Glu Arg Arg Arg Glu Ser Ala Gly Pro
     610                 615                 620                
 Asn Leu Ser Ser Phe Trp Phe Val Gly Arg Ile Trp Lys Ala Ala Ile
 625                 630                 635                 640
 Gly Gln Val Gly Gly Ser Phe Arg Ser Glu Tyr Trp Ala Phe Ser Glu
                 645                 650                 655    
 Glu Arg His Arg Glu Gly Arg Arg Lys Gly Met Leu Phe Ser Gln Ile
             660                 665                 670        
 Leu His Met Phe Gln Ile Cys Lys Ser Pro Gly Lys Leu Pro Tyr Gly
         675                 680                 685            
 Gly Glu Ser Ser Tyr Ser Thr Phe Leu Arg Lys Asn Tyr Ser Pro Arg
     690                 695                 700                
 Arg Ser Ala Val Leu Glu Trp Met Lys Leu Ser Val Gln Leu Glu Ser
 705                 710                 715                 720
 Asn Val Ser Asp Ser Val His Gln Gln Thr Arg Phe Val Leu Gly Gln
                 725                 730                 735    
 Lys Lys Gln Ile
             740



      <210> 1648
      <211> 175
      <212> PRT
      <213> Homo sapiens


      <400> 1648
 Pro Cys Val Tyr Ser Gln Phe Pro Ala Gly Glu Gln Cys Leu Lys Leu
   1               5                  10                  15    
 His Ser Pro Ala Glu Ala Ser Pro Pro Ala Leu Glu Ala Ser Glu Ala
              20                  25                  30        
 Gln Thr Arg Lys Ala Pro Glu Cys Gly Ser Gly Val Pro Glu Val Ala
          35                  40                  45            
 Gly Gly Ser Cys Pro Cys Leu Leu Leu Cys Leu Pro Arg His Gln Ala
      50                  55                  60                
 Val Pro Thr Gln Gly Pro Gly Thr Tyr Ser Pro Cys Thr Ser His Gln
  65                  70                  75                  80
 Pro His Ile Phe Pro Arg Pro Ala Ala Pro His His Leu Gly Leu Leu
                  85                  90                  95    
 Gln Asn Pro His Asn Ala Ala Ser Cys Ile Gln Cys Leu Tyr Pro Ala
             100                 105                 110        
 Gly Val Ala Thr Thr Met Pro Arg Arg Lys Ala Glu Gly Asp Ala Glu
         115                 120                 125            
 Gly Asp Lys Ala Lys Val Lys Asp Glu Pro Gln Arg Arg Pro Ala Lys
     130                 135                 140                
 Leu Ser Ala Lys Pro Ala Pro Pro Asn Pro Glu Ala Lys Pro Lys Asn
 145                 150                 155                 160
 Ala Pro Gly Val Thr Leu Ser Leu Arg Gly Thr Ala Thr Arg Phe
                 165                 170                 175



      <210> 1649
      <211> 466
      <212> PRT
      <213> Homo sapiens


      <400> 1649
 Met Thr Lys Lys Arg Arg Asn Asn Gly Arg Ala Lys Lys Gly Arg Gly
   1               5                  10                  15    
 His Val Gln Pro Ile Arg Cys Thr Asn Cys Ala Arg Cys Val Pro Lys
              20                  25                  30        
 Asp Asn Ala Ile Lys Lys Phe Val Ile Arg Asn Ile Val Glu Ala Ala
          35                  40                  45            
 Ala Val Arg Asp Ile Ser Glu Ala Ser Val Phe Asp Ala Tyr Val Leu
      50                  55                  60                
 Pro Lys Leu Tyr Val Lys Leu His Tyr Cys Val Ser Cys Ala Ile His
  65                  70                  75                  80
 Ser Lys Val Val Arg Asn Arg Ser Arg Glu Ala Arg Lys Asp Arg Thr
                  85                  90                  95    
 Pro Pro Pro Arg Phe Arg Pro Ala Gly Ala Ala Pro Arg Pro Pro Pro
             100                 105                 110        
 Lys Pro Met Ser Gly Ala Gly Arg Gly Arg Ser His Leu Asp Glu Gly
         115                 120                 125            
 Arg Glu Gly Ala Gly Asp Glu Val Gly Glu Leu Ser Leu Gln Gln Glu
     130                 135                 140                
 Ile Asp Lys Asp Pro Leu Gly Gly Ala Leu Gly Ala Gly Ser Arg Gly
 145                 150                 155                 160
 Thr Lys Thr Thr Gly Met Gln Ala Gly Ile Gly Gly Gly Glu Gln Val
                 165                 170                 175    
 Leu Val Phe Trp Asp Ser Ser Leu Pro Ala Val Val Asp Ser Cys Phe
             180                 185                 190        
 His Pro Val Pro Ser Pro Asp Thr Ser Ala Ala Leu Ser Trp Cys Leu
         195                 200                 205            
 Leu Ser Phe Ser Arg Thr Pro Gln Gln Pro Ser Pro Gly Asn Phe Arg
     210                 215                 220                
 Pro Glu His Leu Pro Leu Leu Phe Leu Ser Thr Val Leu Pro Gln Ser
 225                 230                 235                 240
 Val Ala Gln Thr Gln Ala Ser Gly Lys Tyr Leu Pro Ser Arg Trp Ser
                 245                 250                 255    
 Gln Asp Arg Cys Gly Glu Ser Arg Glu Ala Pro Leu Pro Ser Lys Thr
             260                 265                 270        
 Leu Glu Gly Glu Thr Pro Glu Gly Val Gly Ala Glu Leu Arg Cys Val
         275                 280                 285            
 Arg Leu Pro Gly Pro Glu Trp Asn Ser Val Leu Lys Pro Gly Phe Ser
     290                 295                 300                
 Leu Gln Leu Asp Ser Ser Ser Ala Arg Met Ala Leu Val Phe Val Tyr
 305                 310                 315                 320
 Gly Thr Leu Lys Arg Gly Gln Pro Asn His Arg Val Leu Arg Asp Gly
                 325                 330                 335    
 Ala His Gly Ser Ala Ala Phe Arg Ala Arg Gly Arg Thr Leu Glu Pro
             340                 345                 350        
 Tyr Pro Leu Val Ile Ala Gly Glu His Asn Ile Pro Trp Leu Leu His
         355                 360                 365            
 Leu Pro Gly Ser Gly Arg Leu Val Glu Gly Glu Val Tyr Ala Val Asp
     370                 375                 380                
 Glu Arg Met Leu Arg Phe Leu Asp Asp Phe Glu Ser Cys Pro Ala Leu
 385                 390                 395                 400
 Tyr Gln Arg Thr Val Leu Arg Val Gln Leu Leu Glu Asp Arg Ala Pro
                 405                 410                 415    
 Gly Ala Glu Glu Pro Pro Ala Pro Thr Ala Val Gln Cys Phe Val Tyr
             420                 425                 430        
 Ser Arg Ala Thr Phe Pro Pro Glu Trp Ala Gln Leu Pro His His Asp
         435                 440                 445            
 Ser Tyr Asp Ser Glu Gly Pro His Gly Leu Arg Tyr Asn Pro Arg Glu
     450                 455                 460                
 Asn Arg
 465    



      <210> 1650
      <211> 84
      <212> PRT
      <213> Homo sapiens


      <400> 1650
 Pro Thr Arg Pro Cys Lys Pro Pro Gln Thr Ser Pro Asn Ser Gly Lys
   1               5                  10                  15    
 Leu Ser Pro Ser Ser Asn Gly Cys Met Asn Thr Leu His Ile Ser Ser
              20                  25                  30        
 Thr Asn Thr Val Gly Glu Val Ile Glu Ala Leu Leu Lys Lys Phe Leu
          35                  40                  45            
 Val Thr Glu Ser Pro Ala Lys Phe Ala Leu Tyr Lys Arg Cys His Arg
      50                  55                  60                
 Glu Asp Gln Val Tyr Ala Cys Lys Leu Ser Asp Arg Glu His Pro Leu
  65                  70                  75                  80
 Tyr Leu His Asp
                



      <210> 1651
      <211> 411
      <212> PRT
      <213> Homo sapiens


      <400> 1651
 Ser Ser Ala Arg Ala Arg Arg Ser Leu Phe Ala Ser Thr Ala Gln Ser
   1               5                  10                  15    
 Pro Arg Ile Leu Arg Ser Glu Pro Val Arg Thr Pro Pro Ile Pro Ala
              20                  25                  30        
 Phe Ser Pro Leu Lys Thr Leu Arg Ile Met Ser Leu His Gln Phe Leu
          35                  40                  45            
 Leu Glu Pro Ile Thr Cys His Ala Trp Asn Arg Asp Arg Thr Gln Ile
      50                  55                  60                
 Ala Leu Ser Pro Asn Asn His Glu Val His Ile Tyr Lys Lys Asn Gly
  65                  70                  75                  80
 Ser Gln Trp Val Lys Ala His Glu Leu Lys Glu His Asn Gly His Ile
                  85                  90                  95    
 Thr Gly Ile Asp Trp Ala Pro Lys Ser Asp Arg Ile Val Thr Cys Gly
             100                 105                 110        
 Ala Asp Arg Asn Ala Tyr Val Trp Ser Gln Lys Asp Gly Val Trp Lys
         115                 120                 125            
 Pro Thr Leu Val Ile Leu Arg Ile Asn Arg Ala Ala Thr Phe Val Lys
     130                 135                 140                
 Trp Ser Pro Leu Glu Asn Lys Phe Ala Val Gly Ser Gly Ala Arg Leu
 145                 150                 155                 160
 Ile Ser Val Cys Tyr Phe Glu Ser Glu Asn Asp Trp Trp Val Ser Lys
                 165                 170                 175    
 His Ile Lys Lys Pro Ile Arg Ser Thr Val Leu Ser Leu Asp Trp His
             180                 185                 190        
 Pro Asn Asn Val Leu Leu Ala Ala Gly Ser Cys Asp Phe Lys Cys Arg
         195                 200                 205            
 Val Phe Ser Ala Tyr Ile Lys Glu Val Asp Glu Lys Pro Ala Ser Thr
     210                 215                 220                
 Pro Trp Gly Ser Lys Met Pro Phe Gly Gln Leu Met Ser Glu Phe Gly
 225                 230                 235                 240
 Gly Ser Gly Thr Gly Gly Trp Val His Gly Val Ser Phe Ser Ala Ser
                 245                 250                 255    
 Gly Ser Arg Leu Ala Trp Val Ser His Asp Ser Thr Val Ser Val Ala
             260                 265                 270        
 Asp Ala Ser Lys Ser Val Gln Val Ser Thr Leu Lys Thr Glu Phe Leu
         275                 280                 285            
 Pro Leu Leu Ser Val Ser Phe Val Ser Glu Asn Ser Val Val Ala Ala
     290                 295                 300                
 Gly His Asp Cys Cys Pro Met Leu Phe Asn Tyr Asp Asp Arg Gly Cys
 305                 310                 315                 320
 Leu Thr Phe Val Ser Lys Leu Asp Ile Pro Lys Gln Ser Ile Gln Arg
                 325                 330                 335    
 Asn Met Ser Ala Met Glu Arg Phe Arg Asn Met Asp Lys Arg Ala Thr
             340                 345                 350        
 Thr Glu Asp Arg Asn Thr Ala Leu Glu Thr Leu His Gln Asn Ser Ile
         355                 360                 365            
 Thr Gln Val Ser Ile Tyr Glu Val Asp Lys Gln Asp Cys Arg Lys Phe
     370                 375                 380                
 Cys Thr Thr Gly Ile Asp Gly Ala Met Thr Ile Trp Asp Phe Lys Thr
 385                 390                 395                 400
 Leu Glu Ser Ser Ile Gln Gly Leu Arg Ile Met
                 405                 410    



      <210> 1652
      <211> 135
      <212> PRT
      <213> Homo sapiens


      <400> 1652
 Cys Ala Ala Thr Met Ser Leu Val Ile Pro Glu Lys Phe Gln His Ile
   1               5                  10                  15    
 Leu Arg Val Leu Asn Thr Asn Ile Asp Gly Arg Arg Lys Ile Ala Phe
              20                  25                  30        
 Ala Ile Thr Gly Ile Lys Gly Val Gly Arg Lys Tyr Ala His Val Gly
          35                  40                  45            
 Leu Arg Lys Ala Asn Ile Asp Leu Thr Lys Arg Ala Gly Glu Leu Thr
      50                  55                  60                
 Glu Asp Glu Val Glu Arg Val Ile Thr Ile Met Gln Asn Pro Arg Gln
  65                  70                  75                  80
 Tyr Lys Met Pro Asp Trp Phe Leu Asn Arg His Asn Asp Val Lys Asp
                  85                  90                  95    
 Gly Glu Tyr Ser Gln Val Leu Ser Asn Gly Leu Asp Asn Lys Leu Arg
             100                 105                 110        
 Glu Asp Leu Glu Arg Leu Lys Lys Ile Pro Ala His Arg Gly Leu Arg
         115                 120                 125            
 His Phe Trp Gly Leu Arg Val
     130                 135



      <210> 1653
      <211> 345
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(345)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1653
 Ala Thr Val Gly Gly Arg Glu Ile Tyr Val Lys Gly Phe Val His Tyr
   1               5                  10                  15    
 Lys Val Arg Ala Leu Phe Pro Cys Glu Lys Pro Pro Arg Pro Thr Glu
              20                  25                  30        
 Met Ser Arg His His Ser Arg Phe Glu Arg Asp Tyr Arg Val Gly Trp
          35                  40                  45            
 Asp Arg Arg Glu Trp Ser Val Asn Gly Thr His Gly Thr Thr Ser Ile
      50                  55                  60                
 Cys Ser Val Thr Ser Gly Ala Gly Glu Arg His Ser Gln Gln Pro Gln
  65                  70                  75                  80
 Arg Pro Ala Arg Pro Pro Ala Ala Ala Arg Gly Ala Leu Pro Ala Ala
                  85                  90                  95    
 His Pro Gly Tyr Ser Ser Cys Ser Leu Arg Pro Pro Ala Ala Ala Arg
             100                 105                 110        
 Pro Ser Pro Ala Ser Trp Pro Ala Leu Arg Leu Arg Ser Pro Pro Arg
         115                 120                 125            
 Leu Pro Ala Ser Pro Lys Gly Thr Val Ser Pro Arg Asp Trp Arg Pro
     130                 135                 140                
 Ala Ser Gly Gly Gly Arg Arg Leu Ser Ile Ser Pro His Pro Gly Ile
 145                 150                 155                 160
 Thr Asp Glu Pro Pro Ser Lys Gln Met Arg Glu Ser Asp Asn Pro Gly
                 165                 170                 175    
 Thr Gly Pro Trp Gly Pro Arg Trp Pro Pro Gly Thr Ser Pro Pro Xaa
             180                 185                 190        
 Ser His Thr Pro Met Glu Trp Pro Ser Leu Pro Pro Ser Pro Gly Cys
         195                 200                 205            
 Glu Arg Pro Gly Pro Gly His Trp Gly Asp Pro Leu Thr Ala Ser Pro
     210                 215                 220                
 Arg Gly Ala Pro Ala Pro Ala Asp Ala Arg Pro Leu Pro Leu Pro Gln
 225                 230                 235                 240
 Pro Pro Ser Gln Pro Leu Ser Ser Gly Trp Ser Thr Cys Leu Pro Arg
                 245                 250                 255    
 Pro Cys Met Pro Ala Leu Ser Pro Trp Pro Cys Pro His Cys Pro Val
             260                 265                 270        
 Trp Gly Arg Trp Pro Ala Gln Asp Pro Pro Leu Trp Ala Thr Ala Thr
         275                 280                 285            
 Trp Gln Gly Pro Cys Cys Leu His Arg Arg Gln Pro Ser Arg Pro Pro
     290                 295                 300                
 Leu Ser Pro Val Val Pro Leu Pro Pro Met Gly Pro Pro Gln Pro Thr
 305                 310                 315                 320
 Arg Pro Thr Gly Cys Arg Cys Cys Gly Pro Leu Ala Trp Gly Ser Met
                 325                 330                 335    
 Ser Ser Pro Thr Arg Gly Thr Pro Glu
             340                 345



      <210> 1654
      <211> 240
      <212> PRT
      <213> Homo sapiens


      <400> 1654
 Met Ser Trp Glu Val Val Cys Ala Leu Leu Leu Pro Pro Ala Pro Leu
   1               5                  10                  15    
 Trp Thr Pro Val Leu Ala Pro Leu Arg Ser Leu Val Arg Ser Ala Pro
              20                  25                  30        
 Phe Pro Pro Arg Pro Val Leu Gly Gln Asp Val Leu Pro Ala Leu Arg
          35                  40                  45            
 Thr Leu Glu Gln Gly Pro Ala Thr Pro Arg Ser Leu Tyr Asp Gly Asn
      50                  55                  60                
 Arg Pro Ala Pro Ser Pro Leu Arg Gly Ala Gly Gln Pro Trp Gly Ala
  65                  70                  75                  80
 Leu Lys Thr Gly Ala Gly Ala Trp His Arg His Ser Gly Gln Asp Pro
                  85                  90                  95    
 Thr Ser Leu Gln Leu Leu Leu Thr Thr Pro Gln Ile Pro Arg Ser His
             100                 105                 110        
 Gly Lys Gln Gly Leu Ala Gly Pro Glu Ala Thr Gly Gly Gly Asp Arg
         115                 120                 125            
 Pro Gly Ser Arg Phe Thr Met Glu Pro Ser Leu Gln Cys Ser Pro Phe
     130                 135                 140                
 His Ile Ala Pro Ala Pro Trp Ser Trp Cys Ser Gly Gly Ala Val Gln
 145                 150                 155                 160
 Leu Pro Val Pro Val Cys Leu Cys Ser Pro Asp Thr Arg Ser Pro Gly
                 165                 170                 175    
 Gly Gln Gly Gln Gly Ala Ser Glu Lys Asp Ile Val His Ser Gly Leu
             180                 185                 190        
 Ala Tyr Thr Met Glu Arg Ser Ala Arg Gln Ile Met Arg Thr Ala Met
         195                 200                 205            
 Lys Tyr Asn Leu Gly Leu Asp Leu Arg Thr Ala Ala Tyr Val Asn Ala
     210                 215                 220                
 Ile Glu Lys Val Phe Lys Val Tyr Asn Glu Ala Gly Val Thr Phe Thr
 225                 230                 235                 240





      <210> 1655
      <211> 72
      <212> PRT
      <213> Homo sapiens


      <400> 1655
 Phe Ser Gly Val Ser Val Ala Gln Ala Gly Met Gln Trp Cys Gly Leu
   1               5                  10                  15    
 Gly Ser Leu Gln Pro Leu Pro Pro Gly Phe Lys Arg Leu Ser Cys Phe
              20                  25                  30        
 Ser Leu Pro Ser Ser Trp Asn Cys Gly His Val Leu Pro His Leu Ala
          35                  40                  45            
 Asn Phe Cys Ile Phe Ser Lys Asp Gly Val Trp Pro Cys Trp Pro Gly
      50                  55                  60                
 Trp Ser Arg Thr Pro Asp Leu Arg
  65                  70        



      <210> 1656
      <211> 72
      <212> PRT
      <213> Homo sapiens


      <400> 1656
 Phe Ser Gly Val Ser Val Ala Gln Ala Gly Met Gln Trp Cys Gly Leu
   1               5                  10                  15    
 Gly Ser Leu Gln Pro Leu Pro Pro Gly Phe Lys Arg Leu Ser Cys Phe
              20                  25                  30        
 Ser Leu Pro Ser Ser Trp Asn Cys Gly His Val Leu Pro His Leu Ala
          35                  40                  45            
 Asn Phe Cys Ile Phe Ser Lys Asp Gly Val Trp Pro Cys Trp Pro Gly
      50                  55                  60                
 Trp Ser Arg Thr Pro Asp Leu Arg
  65                  70        



      <210> 1657
      <211> 170
      <212> PRT
      <213> Homo sapiens


      <400> 1657
 Pro Arg Leu Leu Met Glu Ala Gly Pro His Pro Arg Pro Gly His Cys
   1               5                  10                  15    
 Cys Lys Pro Gly Gly Arg Leu Asp Met Asn His Gly Phe Val His His
              20                  25                  30        
 Ile Arg Arg Asn Gln Ile Ala Arg Asp Asp Tyr Asp Lys Lys Val Lys
          35                  40                  45            
 Gln Ala Ala Lys Glu Lys Val Arg Arg Arg His Thr Pro Ala Pro Thr
      50                  55                  60                
 Arg Pro Arg Lys Pro Asp Leu Gln Val Tyr Leu Pro Arg His Arg Asp
  65                  70                  75                  80
 Val Ser Ala His Pro Arg Asn Pro Asp Tyr Glu Glu Ser Gly Glu Ser
                  85                  90                  95    
 Ser Ser Ser Gly Gly Ser Glu Leu Glu Pro Ser Gly His Gln Leu Phe
             100                 105                 110        
 Cys Leu Glu Tyr Glu Ala Asp Ser Gly Glu Val Thr Ser Val Ile Val
         115                 120                 125            
 Tyr Gln Gly Asp Asp Pro Gly Lys Val Ser Glu Lys Val Ser Ala His
     130                 135                 140                
 Thr Pro Leu Asp Pro Pro Met Arg Glu Ala Leu Lys Leu Arg Ile Gln
 145                 150                 155                 160
 Glu Glu Ile Ala Lys Arg Gln Ser Gln His
                 165                 170



      <210> 1658
      <211> 196
      <212> PRT
      <213> Homo sapiens


      <400> 1658
 Ala Ala Ala Val Ala Glu Leu Pro Val Leu Asp Ala Arg Gly Gln Arg
   1               5                  10                  15    
 Val Pro Val Arg Pro Leu Phe Arg Glu Arg Arg Ala Val Val Val Phe
              20                  25                  30        
 Val Arg His Phe Leu Cys Tyr Ile Cys Lys Glu Tyr Val Glu Asp Leu
          35                  40                  45            
 Ala Lys Ile Pro Arg Ser Phe Leu Gln Glu Ala Asn Val Thr Leu Ile
      50                  55                  60                
 Val Ile Gly Gln Ser Ser Tyr His His Ile Glu Pro Phe Cys Lys Leu
  65                  70                  75                  80
 Thr Gly Tyr Ser His Glu Ile Tyr Val Asp Pro Glu Arg Glu Ile Tyr
                  85                  90                  95    
 Lys Arg Leu Gly Met Lys Arg Gly Glu Glu Ile Ala Ser Ser Gly Gln
             100                 105                 110        
 Ser Pro His Ile Lys Ser Asn Leu Leu Ser Gly Ser Leu Gln Ser Leu
         115                 120                 125            
 Trp Arg Ala Val Thr Gly Pro Leu Phe Asp Phe Gln Gly Asp Pro Ala
     130                 135                 140                
 Gln Gln Gly Gly Thr Leu Ile Leu Gly Pro Gly Asn Asn Ile His Phe
 145                 150                 155                 160
 Ile His Arg Asp Arg Asn Arg Leu Asp His Lys Pro Ile Asn Ser Val
                 165                 170                 175    
 Leu Gln Leu Val Gly Val Gln His Val Asn Phe Thr Asn Arg Pro Ser
             180                 185                 190        
 Val Ile His Val
         195    



      <210> 1659
      <211> 196
      <212> PRT
      <213> Homo sapiens


      <400> 1659
 Ala Ala Ala Val Ala Glu Leu Pro Val Leu Asp Ala Arg Gly Gln Arg
   1               5                  10                  15    
 Val Pro Val Arg Pro Leu Phe Arg Glu Arg Arg Ala Val Val Val Phe
              20                  25                  30        
 Val Arg His Phe Leu Cys Tyr Ile Cys Lys Glu Tyr Val Glu Asp Leu
          35                  40                  45            
 Ala Lys Ile Pro Arg Ser Phe Leu Gln Glu Ala Asn Val Thr Leu Ile
      50                  55                  60                
 Val Ile Gly Gln Ser Ser Tyr His His Ile Glu Pro Phe Cys Lys Leu
  65                  70                  75                  80
 Thr Gly Tyr Ser His Glu Ile Tyr Val Asp Pro Glu Arg Glu Ile Tyr
                  85                  90                  95    
 Lys Arg Leu Gly Met Lys Arg Gly Glu Glu Ile Ala Ser Ser Gly Gln
             100                 105                 110        
 Ser Pro His Ile Lys Ser Asn Leu Leu Ser Gly Ser Leu Gln Ser Leu
         115                 120                 125            
 Trp Arg Ala Val Thr Gly Pro Leu Phe Asp Phe Gln Gly Asp Pro Ala
     130                 135                 140                
 Gln Gln Gly Gly Thr Leu Ile Leu Gly Pro Gly Asn Asn Ile His Phe
 145                 150                 155                 160
 Ile His Arg Asp Arg Asn Arg Leu Asp His Lys Pro Ile Asn Ser Val
                 165                 170                 175    
 Leu Gln Leu Val Gly Val Gln His Val Asn Phe Thr Asn Arg Pro Ser
             180                 185                 190        
 Val Ile His Val
         195    



      <210> 1660
      <211> 196
      <212> PRT
      <213> Homo sapiens


      <400> 1660
 Ala Ala Ala Val Ala Glu Leu Pro Val Leu Asp Ala Arg Gly Gln Arg
   1               5                  10                  15    
 Val Pro Val Arg Pro Leu Phe Arg Glu Arg Arg Ala Val Val Val Phe
              20                  25                  30        
 Val Arg His Phe Leu Cys Tyr Ile Cys Lys Glu Tyr Val Glu Asp Leu
          35                  40                  45            
 Ala Lys Ile Pro Arg Ser Phe Leu Gln Glu Ala Asn Val Thr Leu Ile
      50                  55                  60                
 Val Ile Gly Gln Ser Ser Tyr His His Ile Glu Pro Phe Cys Lys Leu
  65                  70                  75                  80
 Thr Gly Tyr Ser His Glu Ile Tyr Val Asp Pro Glu Arg Glu Ile Tyr
                  85                  90                  95    
 Lys Arg Leu Gly Met Lys Arg Gly Glu Glu Ile Ala Ser Ser Gly Gln
             100                 105                 110        
 Ser Pro His Ile Lys Ser Asn Leu Leu Ser Gly Ser Leu Gln Ser Leu
         115                 120                 125            
 Trp Arg Ala Val Thr Gly Pro Leu Phe Asp Phe Gln Gly Asp Pro Ala
     130                 135                 140                
 Gln Gln Gly Gly Thr Leu Ile Leu Gly Pro Gly Asn Asn Ile His Phe
 145                 150                 155                 160
 Ile His Arg Asp Arg Asn Arg Leu Asp His Lys Pro Ile Asn Ser Val
                 165                 170                 175    
 Leu Gln Leu Val Gly Val Gln His Val Asn Phe Thr Asn Arg Pro Ser
             180                 185                 190        
 Val Ile His Val
         195    



      <210> 1661
      <211> 216
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(216)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1661
 Lys Ile Phe Leu Ser Asp Cys Leu Ala Cys Asp Ser Cys Met Thr Ala
   1               5                  10                  15    
 Glu Lys Gly Val Gln Leu Ser Gln Gln Asn Ala Lys Asp Phe Phe Arg
              20                  25                  30        
 Val Leu Asn Leu Asn Lys Lys Cys Asp Thr Ser Lys His Lys Val Leu
          35                  40                  45            
 Val Val Ser Val Cys Pro Gln Ser Leu Pro Tyr Phe Ala Ala Lys Phe
      50                  55                  60                
 Asn Leu Ser Val Thr Asp Ala Ser Arg Arg Leu Cys Gly Phe Leu Lys
  65                  70                  75                  80
 Ser Leu Gly Val His Tyr Val Phe Asp Thr Thr Ile Ala Ala Asp Phe
                  85                  90                  95    
 Ser His Arg Trp Arg Met Leu Lys Trp Gln Arg Pro Ser Pro Asp Ser
             100                 105                 110        
 Arg Arg Thr Cys Gly Xaa Gly Pro Ala Ala Ala Asp Gly Arg His Leu
         115                 120                 125            
 Arg Xaa His Pro Cys Ala Ala Ser Gly Val Gln Cys Lys Arg Ala Gly
     130                 135                 140                
 Ala Val Pro Gly Val Ala Gly Gly Asp Gln Leu Pro Gln Gly Pro Arg
 145                 150                 155                 160
 Gly Ala Ala Tyr His Val Pro Glu Pro Gly Ala Trp His Thr Gln Pro
                 165                 170                 175    
 Gly His Gln Val Val Lys Ser Gly Gln Gly Leu Pro Ala Ala Leu Gly
             180                 185                 190        
 Ala Arg Ala Lys Ser Leu Ser Val Glu Gly Gly Ala Ala Leu Ser Gly
         195                 200                 205            
 Val Leu Lys Thr Leu Lys Lys Thr
     210                 215    



      <210> 1662
      <211> 362
      <212> PRT
      <213> Homo sapiens


      <400> 1662
 Gln Met Glu His Val Val Gln Ala Cys His Arg Phe Ile Gln Ala Ser
   1               5                  10                  15    
 Tyr Glu Pro Leu Gly Ile Ser Leu Arg Pro Leu Glu Ala Glu Pro Pro
              20                  25                  30        
 Thr Pro Pro Thr Ala Pro Pro Pro Gly Ser Pro Arg Arg Ser Glu Gly
          35                  40                  45            
 His Pro Asp Pro Pro Thr Glu Ser Arg Ser Cys Ser Gln Gly Pro Pro
      50                  55                  60                
 Ser Pro Ala Ser Pro Asp Pro Lys Ala Cys Asn Trp Lys Lys Tyr Lys
  65                  70                  75                  80
 Tyr Ile Val Leu Asn Ser Gln Ala Ser Gln Ala Gly Ser Leu Val Gly
                  85                  90                  95    
 Glu Arg Ser Ser Gly Gln Pro Cys Pro Gln Ala Arg Leu Pro Ser Gly
             100                 105                 110        
 Asp Glu Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu
         115                 120                 125            
 Glu Gly Pro Ile Pro Gly Pro Gln Ser Arg Leu Ser Pro Thr Ala Ala
     130                 135                 140                
 Thr Val Gln Phe Lys Cys Gly Ala Pro Ala Ser Thr Pro Tyr Leu Leu
 145                 150                 155                 160
 Thr Ser Gln Ala Gln Asp Thr Ser Gly Ser Pro Ser Glu Arg Ala Arg
                 165                 170                 175    
 Pro Leu Pro Gly Ser Glu Phe Phe Ser Cys Gln Asn Cys Glu Ala Val
             180                 185                 190        
 Ala Gly Cys Ser Ser Gly Leu Asp Ser Leu Val Pro Gly Asp Glu Asp
         195                 200                 205            
 Lys Pro Tyr Lys Cys Gln Leu Cys Arg Ser Ser Phe Arg Tyr Lys Gly
     210                 215                 220                
 Asn Leu Ala Ser His Arg Thr Val His Thr Gly Glu Lys Pro Tyr His
 225                 230                 235                 240
 Cys Ser Ile Cys Gly Ala Arg Phe Asn Arg Pro Ala Asn Leu Lys Thr
                 245                 250                 255    
 His Ser Arg Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Glu Thr Cys
             260                 265                 270        
 Gly Ser Arg Phe Val Gln Val Ala His Leu Arg Ala His Val Leu Ile
         275                 280                 285            
 His Thr Gly Glu Lys Pro Tyr Pro Cys Pro Thr Cys Gly Thr Arg Phe
     290                 295                 300                
 Arg His Leu Gln Thr Leu Lys Ser His Val Arg Ile His Thr Gly Glu
 305                 310                 315                 320
 Lys Pro Tyr His Cys Asp Pro Cys Gly Leu His Phe Arg His Lys Ser
                 325                 330                 335    
 Gln Leu Arg Leu His Leu Arg Gln Lys His Gly Ala Ala Thr Asn Thr
             340                 345                 350        
 Lys Val His Tyr His Ile Leu Gly Gly Pro
         355                 360        



      <210> 1663
      <211> 459
      <212> PRT
      <213> Homo sapiens


      <400> 1663
 Leu Gly Asp Ala Arg Ala Pro Glu Lys Met Ser Ala Ile Gln Ala Ala
   1               5                  10                  15    
 Trp Pro Ser Gly Thr Glu Cys Ile Ala Lys Tyr Asn Phe His Gly Thr
              20                  25                  30        
 Ala Glu Gln Asp Leu Pro Phe Cys Lys Gly Asp Val Leu Thr Ile Val
          35                  40                  45            
 Ala Val Thr Lys Asp Pro Asn Trp Tyr Lys Ala Lys Asn Lys Val Gly
      50                  55                  60                
 Arg Glu Gly Ile Ile Pro Ala Asn Tyr Val Gln Lys Arg Glu Gly Val
  65                  70                  75                  80
 Lys Ala Gly Thr Lys Leu Ser Leu Met Pro Trp Phe His Gly Lys Ile
                  85                  90                  95    
 Thr Arg Glu Gln Ala Glu Arg Leu Leu Tyr Pro Pro Glu Thr Gly Leu
             100                 105                 110        
 Phe Leu Val Arg Glu Ser Thr Asn Tyr Pro Gly Asp Tyr Thr Leu Cys
         115                 120                 125            
 Val Ser Cys Asp Gly Lys Val Glu His Tyr Arg Ile Met Tyr His Ala
     130                 135                 140                
 Ser Lys Leu Ser Ile Asp Glu Glu Val Tyr Phe Glu Asn Leu Met Gln
 145                 150                 155                 160
 Leu Val Glu His Tyr Thr Ser Asp Ala Asp Gly Leu Cys Thr Arg Leu
                 165                 170                 175    
 Ile Lys Pro Lys Val Met Glu Gly Thr Val Ala Ala Gln Asp Glu Phe
             180                 185                 190        
 Tyr Arg Ser Gly Trp Ala Leu Asn Met Lys Glu Leu Lys Leu Leu Gln
         195                 200                 205            
 Thr Ile Gly Lys Gly Glu Phe Gly Asp Val Met Leu Gly Asp Tyr Arg
     210                 215                 220                
 Gly Asn Lys Val Ala Val Lys Cys Ile Lys Asn Asp Ala Thr Ala Gln
 225                 230                 235                 240
 Ala Phe Leu Ala Glu Ala Ser Val Met Thr Gln Leu Arg His Ser Asn
                 245                 250                 255    
 Leu Val Gln Leu Leu Gly Val Ile Val Glu Glu Lys Gly Gly Leu Tyr
             260                 265                 270        
 Ile Val Thr Glu Tyr Met Ala Lys Gly Ser Leu Val Asp Tyr Leu Arg
         275                 280                 285            
 Ser Arg Gly Arg Ser Val Leu Gly Gly Asp Cys Leu Leu Lys Phe Ser
     290                 295                 300                
 Leu Asp Val Cys Glu Ala Met Glu Tyr Leu Glu Gly Asn Asn Phe Val
 305                 310                 315                 320
 His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Ser Glu Asp Asn Val
                 325                 330                 335    
 Ala Lys Val Ser Asp Phe Gly Leu Thr Lys Glu Ala Ser Ser Thr Gln
             340                 345                 350        
 Asp Thr Gly Lys Leu Pro Val Lys Trp Thr Ala Pro Glu Ala Leu Arg
         355                 360                 365            
 Glu Lys Lys Phe Ser Thr Lys Ser Asp Val Trp Ser Phe Gly Ile Leu
     370                 375                 380                
 Leu Trp Glu Ile Tyr Ser Phe Gly Arg Val Pro Tyr Pro Arg Ile Pro
 385                 390                 395                 400
 Leu Lys Asp Val Val Pro Arg Val Glu Lys Gly Tyr Lys Met Asp Ala
                 405                 410                 415    
 Pro Asp Gly Cys Pro Pro Ala Val Tyr Glu Val Met Lys Asn Cys Trp
             420                 425                 430        
 His Leu Asp Ala Ala Met Arg Pro Ser Phe Leu Gln Leu Arg Glu Gln
         435                 440                 445            
 Leu Glu His Ile Lys Thr His Glu Leu His Leu
     450                 455                



      <210> 1664
      <211> 708
      <212> PRT
      <213> Homo sapiens


      <400> 1664
 Ala Gly Gln Thr Pro Gly His Arg Ala Ser Gly Pro Ser Glu Arg Ser
   1               5                  10                  15    
 Pro Ala Pro Arg Ser Arg Leu Gln Pro Gly Gly Glu Ala Ala Thr Arg
              20                  25                  30        
 Thr Glu Pro Ala Thr Pro Gly Arg Arg Ala Gly Pro Gly Ser Ala Thr
          35                  40                  45            
 Met Glu Ala Leu Met Ala Arg Gly Ala Leu Thr Gly Pro Leu Arg Ala
      50                  55                  60                
 Leu Cys Leu Leu Gly Cys Leu Leu Ser His Ala Ala Ala Ala Pro Ser
  65                  70                  75                  80
 Pro Ile Ile Lys Phe Pro Gly Asp Val Ala Pro Lys Thr Asp Lys Glu
                  85                  90                  95    
 Leu Ala Val Gln Tyr Leu Asn Thr Phe Tyr Gly Cys Pro Lys Glu Ser
             100                 105                 110        
 Cys Asn Leu Phe Val Leu Lys Asp Thr Leu Lys Lys Met Gln Lys Phe
         115                 120                 125            
 Phe Gly Leu Pro Gln Thr Gly Asp Leu Asp Gln Asn Thr Ile Glu Thr
     130                 135                 140                
 Met Arg Lys Pro Arg Cys Gly Asn Pro Asp Val Ala Asn Tyr Asn Phe
 145                 150                 155                 160
 Phe Pro Arg Lys Pro Lys Trp Asp Lys Asn Gln Ile Thr Tyr Arg Ile
                 165                 170                 175    
 Ile Gly Tyr Thr Pro Asp Leu Asp Pro Glu Thr Val Asp Asp Ala Phe
             180                 185                 190        
 Ala Arg Ala Phe Gln Val Trp Ser Asp Val Thr Pro Leu Arg Phe Ser
         195                 200                 205            
 Arg Ile His Asp Gly Glu Ala Asp Ile Met Ile Asn Phe Gly Arg Trp
     210                 215                 220                
 Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala
 225                 230                 235                 240
 His Ala Phe Ala Pro Gly Thr Gly Val Gly Gly Asp Ser His Phe Asp
                 245                 250                 255    
 Asp Asp Glu Leu Trp Thr Leu Gly Glu Gly Gln Val Val Arg Val Lys
             260                 265                 270        
 Tyr Gly Asn Ala Asp Gly Glu Tyr Cys Lys Phe Pro Phe Leu Phe Asn
         275                 280                 285            
 Gly Lys Glu Tyr Asn Ser Cys Thr Asp Thr Gly Arg Ser Asp Gly Phe
     290                 295                 300                
 Leu Trp Cys Ser Thr Thr Tyr Asn Phe Glu Lys Asp Gly Lys Tyr Gly
 305                 310                 315                 320
 Phe Cys Pro His Glu Ala Leu Phe Thr Met Gly Gly Asn Ala Glu Gly
                 325                 330                 335    
 Gln Pro Cys Lys Phe Pro Phe Arg Phe Gln Gly Thr Ser Tyr Asp Ser
             340                 345                 350        
 Cys Thr Thr Glu Gly Arg Thr Asp Gly Tyr Arg Trp Cys Gly Thr Thr
         355                 360                 365            
 Glu Asp Tyr Asp Arg Asp Lys Lys Tyr Gly Phe Cys Pro Glu Thr Ala
     370                 375                 380                
 Met Ser Thr Val Gly Gly Asn Ser Glu Gly Ala Pro Cys Val Phe Pro
 385                 390                 395                 400
 Phe Thr Phe Leu Gly Asn Lys Tyr Glu Ser Cys Thr Ser Ala Gly Arg
                 405                 410                 415    
 Ser Asp Gly Lys Met Trp Cys Ala Thr Thr Ala Asn Tyr Asp Asp Asp
             420                 425                 430        
 Arg Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val
         435                 440                 445            
 Ala Ala His Glu Phe Gly His Ala Met Gly Leu Glu His Ser Gln Asp
     450                 455                 460                
 Pro Gly Ala Leu Met Ala Pro Ile Tyr Thr Tyr Thr Lys Asn Phe Arg
 465                 470                 475                 480
 Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Glu Leu Tyr Gly Ala Ser
                 485                 490                 495    
 Pro Asp Ile Asp Leu Gly Thr Gly Pro Thr Pro Thr Leu Gly Pro Val
             500                 505                 510        
 Thr Pro Glu Ile Cys Lys Gln Asp Ile Val Phe Asp Gly Ile Ala Gln
         515                 520                 525            
 Ile Arg Gly Glu Ile Phe Phe Phe Lys Asp Arg Phe Ile Trp Arg Thr
     530                 535                 540                
 Val Thr Pro Arg Asp Lys Pro Met Gly Pro Leu Leu Val Ala Thr Phe
 545                 550                 555                 560
 Trp Pro Glu Leu Pro Glu Lys Ile Asp Ala Val Tyr Glu Ala Pro Gln
                 565                 570                 575    
 Glu Glu Lys Ala Val Phe Phe Ala Gly Asn Glu Tyr Trp Ile Tyr Ser
             580                 585                 590        
 Ala Ser Thr Leu Glu Arg Gly Tyr Pro Lys Pro Leu Thr Ser Leu Gly
         595                 600                 605            
 Leu Pro Pro Asp Val Gln Arg Val Asp Ala Ala Phe Asn Trp Ser Lys
     610                 615                 620                
 Asn Lys Lys Thr Tyr Ile Phe Ala Gly Asp Lys Phe Trp Arg Tyr Asn
 625                 630                 635                 640
 Glu Val Lys Lys Lys Met Asp Pro Gly Phe Pro Lys Leu Ile Ala Asp
                 645                 650                 655    
 Ala Trp Asn Ala Ile Pro Asp Asn Leu Asp Ala Val Val Asp Leu Gln
             660                 665                 670        
 Gly Gly Gly His Ser Tyr Phe Phe Lys Gly Ala Tyr Tyr Leu Lys Leu
         675                 680                 685            
 Glu Asn Gln Ser Leu Lys Ser Val Lys Phe Gly Ser Ile Lys Ser Asp
     690                 695                 700                
 Trp Leu Gly Cys
 705            



      <210> 1665
      <211> 24
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(24)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1665
 Ser Cys Asn Ser Ile Phe Ala Arg Ser Val Arg Ala Cys Cys Ser Xaa
   1               5                  10                  15    
 Val Ala Ser Ser Ser Phe Cys Cys
              20                



      <210> 1666
      <211> 107
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(107)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1666
 Thr Leu Ala Xaa Ala Ala Ala Ala Ser Thr Ser Cys Ser Pro Arg Pro
   1               5                  10                  15    
 Pro Pro Pro Ser Pro Ala Ser Thr Thr Thr Arg Trp Arg Ala Pro Trp
              20                  25                  30        
 Arg Thr Arg Xaa Glu Pro Pro Glu Ser Leu Cys Thr Gly Met Arg Ser
          35                  40                  45            
 Trp Pro Ser Gly Met Thr Ala Cys Thr Gln Thr Pro Ser Thr Ala Pro
      50                  55                  60                
 Pro Ser Pro His Pro Pro Ser Leu Ser Asp Ser Ser Ala Leu Cys Ser
  65                  70                  75                  80
 Ser Ala Ser Val Arg Arg Met Trp Ile Met Lys Arg Leu Lys Pro Ser
                  85                  90                  95    
 Met Met His Val Leu Cys Met Thr Val Asp Leu
             100                 105        



      <210> 1667
      <211> 244
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(244)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1667
 Cys Arg Asp Met Ala Ala Phe Ile Val Pro Ser Pro Ala Arg Arg Cys
   1               5                  10                  15    
 Ser Gln Lys Gly Ser Leu Gly His Leu Pro Thr Gln Pro Trp Leu Trp
              20                  25                  30        
 Ala Ala Met Ser Pro Arg Gly Gln Glu Arg Gly Thr Ser His Ser Gln
          35                  40                  45            
 Ala Arg Glu Pro Gln Arg Pro Gly Arg Trp Leu Leu Gly Ser Leu Gln
      50                  55                  60                
 Ser Ser Pro Gly Thr Leu Gly Gln Ala Gly Thr Ala Ser Arg Arg Arg
  65                  70                  75                  80
 Gly Cys Met Val Gln Arg Trp Val Gln Val Ala Thr Gly Arg Arg Ala
                  85                  90                  95    
 Val Gln Val Pro Lys Gly Ala Leu Gly Leu Ala Leu Gly Glu Thr Ser
             100                 105                 110        
 Pro Gly Ala Ser Arg Gly Met Ser Gly Gly Ala Gly Gly Cys Trp Ala
         115                 120                 125            
 Leu Gly Trp Ala Pro Ser Pro Val Leu Pro Ser Trp Leu Leu Glu Gly
     130                 135                 140                
 Pro Pro Pro Trp Leu Ser Ile Ile Ser Asp Ser Gly Thr Gln Arg Pro
 145                 150                 155                 160
 Ser Pro Arg Arg Cys Pro Ala Arg Pro Ser Pro Trp Gly Pro Gln Cys
                 165                 170                 175    
 Trp Arg Gly Gly Arg Ile Ala Ser Ala Glu Ala Ser Ser Thr Xaa Thr
             180                 185                 190        
 Pro Gly Ser Gly Ser Arg Ala Arg Ser Gly Arg Arg Ser Pro Gly Ser
         195                 200                 205            
 Arg Arg Arg Ser Ala Ser Ala Pro Ser Pro Thr Pro Pro Thr Asp Ala
     210                 215                 220                
 Cys Ala Xaa Ser Cys Val Ala Arg Pro Ala Gly Ser Arg Ser Ser Arg
 225                 230                 235                 240
 Pro Ala Ala Ala
                



      <210> 1668
      <211> 285
      <212> PRT
      <213> Homo sapiens


      <400> 1668
 Phe Arg Ala Leu Ala Pro Ala Ser Thr Ala Ser Gly Ala Ala Ser Val
   1               5                  10                  15    
 Gly Gln Thr Ser Ala Arg Lys Arg Asp Ala Pro Ala Pro Arg Pro Leu
              20                  25                  30        
 Pro Ala Ser Glu Gly His Leu Gln Pro Pro Ala Gln Thr Ser Gly Pro
          35                  40                  45            
 Thr Gly Ser Pro Pro Cys Ile Gln Thr Ser Pro Asp Pro Arg Leu Ser
      50                  55                  60                
 Pro Ser Phe Arg Ala Arg Pro Glu Ala Leu His Ser Ser Pro Glu Asp
  65                  70                  75                  80
 Pro Val Leu Pro Arg Pro Pro Gln Thr Leu Pro Leu Asp Val Gly Gln
                  85                  90                  95    
 Gly Pro Ser Glu Pro Gly Thr His Ser Pro Gly Leu Leu Ser Pro Thr
             100                 105                 110        
 Phe Arg Pro Gly Ala Pro Ser Gly Gln Thr Val Pro Pro Pro Leu Pro
         115                 120                 125            
 Lys Pro Pro Arg Ser Pro Ser Arg Ser Pro Ser His Ser Pro Asn Arg
     130                 135                 140                
 Ser Pro Cys Val Pro Pro Ala Pro Asp Met Ala Leu Pro Arg Leu Gly
 145                 150                 155                 160
 Thr Gln Ser Thr Gly Pro Gly Arg Cys Leu Ser Pro Asn Leu Gln Ala
                 165                 170                 175    
 Gln Glu Ala Pro Ala Pro Val Thr Thr Ser Ser Ser Thr Ser Thr Leu
             180                 185                 190        
 Ser Ser Ser Pro Trp Ser Ala Gln Pro Thr Trp Lys Ser Asp Pro Gly
         195                 200                 205            
 Phe Arg Ile Thr Val Val Thr Trp Asn Val Gly Thr Ala Met Pro Pro
     210                 215                 220                
 Asp Asp Val Thr Ser Leu Leu His Leu Gly Gly Gly Asp Asp Ser Asp
 225                 230                 235                 240
 Gly Ala Asp Met Ile Ala Ile Gly Leu Gln Glu Val Asn Ser Met Leu
                 245                 250                 255    
 Asn Lys Arg Leu Lys Asp Ala Leu Phe Thr Asp Gln Trp Ser Glu Leu
             260                 265                 270        
 Phe Met Asp Ala Leu Arg Ala Phe His Phe Val Leu Val
         275                 280                 285



      <210> 1669
      <211> 215
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(215)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1669
 Gly Pro Ser Asn Gln Ser Ser Gly Ser Leu Ser Leu Ile Val Thr Gly
   1               5                  10                  15    
 Cys Ser Ser Tyr Trp Ser Xaa Ile Asn Asp Thr Cys Thr Ile Leu Arg
              20                  25                  30        
 Val Leu Ser Ser Asn Phe Gly Arg Gln Xaa Leu Arg Pro Phe Pro Cys
          35                  40                  45            
 Ser Gln Leu Pro Met Ser Gln Gly Cys Leu Trp His Leu Asp Cys Cys
      50                  55                  60                
 Cys Pro Trp Val Pro Tyr Ile Pro Gly Gln Gln Trp Arg Lys Gly Arg
  65                  70                  75                  80
 Gln Arg Met Arg Asn Xaa Gln Ser Leu Leu Gly Ser Asp Gln Glu Ser
                  85                  90                  95    
 Val Gly Leu Glu Asp Leu Cys Val Phe Val Asn Phe Leu Leu His Val
             100                 105                 110        
 Leu Leu Gly Leu Phe Pro Xaa Pro His Glu Leu Phe Leu Leu Pro Val
         115                 120                 125            
 Val Asp Leu Gly Phe Leu Phe Pro Leu Leu Leu Gln Gly Gly Cys His
     130                 135                 140                
 Cys Leu Val Leu Pro Ala Asn Leu Val Ser Gln Ala Pro Gln Ile Gly
 145                 150                 155                 160
 Lys Leu Ser Cys Arg Leu Gln Thr His Asp Leu Glu Gly Ser Arg Asn
                 165                 170                 175    
 His His Pro Leu Phe Leu Val Val Gly Arg Trp Asp Ala Val Lys His
             180                 185                 190        
 Leu Glu Thr Val Gln Ser Gly Leu Ala Ser Leu Gly Phe Val Gly Gln
         195                 200                 205            
 His Thr Ser His Gly Pro Pro
     210                 215



      <210> 1670
      <211> 156
      <212> PRT
      <213> Homo sapiens


      <400> 1670
 Phe Asp Thr Ala Arg Leu His Glu Phe Gly Thr Ser Ile Thr Gln Ile
   1               5                  10                  15    
 Phe Ala Val Asp Asn Arg Glu Asp Leu Gln Lys Trp Met Glu Ala Phe
              20                  25                  30        
 Trp Gln His Phe Phe Asp Leu Ser Gln Trp Lys His Cys Cys Glu Glu
          35                  40                  45            
 Leu Met Lys Ile Glu Ile Met Ser Pro Arg Lys Pro Pro Leu Phe Leu
      50                  55                  60                
 Thr Lys Glu Ala Thr Ser Val Tyr His Asp Met Ser Ile Asp Ser Pro
  65                  70                  75                  80
 Met Lys Leu Glu Ser Leu Thr Asp Ile Ile Gln Lys Lys Ile Glu Glu
                  85                  90                  95    
 Thr Asn Gly Gln Phe Leu Ile Gly Gln Arg Glu Glu Ser Leu Pro Ser
             100                 105                 110        
 Ser Cys Gly Pro His Ser Leu Met Val Thr Ile Lys Trp Ser Ser Arg
         115                 120                 125            
 Lys Arg Tyr Ser Tyr Pro Ala Ser Glu Pro Leu His Asp Glu Lys Gly
     130                 135                 140                
 Lys Lys Arg Gln Ala Pro Leu Pro Pro Ser Asp Lys
 145                 150                 155    



      <210> 1671
      <211> 110
      <212> PRT
      <213> Homo sapiens


      <400> 1671
 Ala Gly Glu Pro Gly Thr Glu Pro Pro Pro Pro Leu Pro Gln Gln Pro
   1               5                  10                  15    
 Pro Met Thr Leu Pro Pro Pro Ala Ala Ala Ala Ala Asn Pro Gly Ala
              20                  25                  30        
 Pro Ala Ala Arg Ala Pro Pro Gly Pro Pro Val Ile Glu Asp Lys Gly
          35                  40                  45            
 Pro Pro Ser Leu Ser Arg Ala Pro Thr Leu Arg Gln Arg Gln Thr Arg
      50                  55                  60                
 Ala Pro Gly Pro Ser Ser Ser Ala Asp Pro Arg Ala Cys Trp Ala Pro
  65                  70                  75                  80
 His Phe Arg Ala Asp Gln Lys Pro Leu His Pro Leu Ala Phe Arg Leu
                  85                  90                  95    
 Leu His Ala Pro Ala Lys Trp Phe Cys Val Leu Tyr Ser Ile
             100                 105                 110



      <210> 1672
      <211> 191
      <212> PRT
      <213> Homo sapiens


      <400> 1672
 Gly Gly Ile Pro His Tyr Leu Arg Gly Val Asn Asn Ala Arg Gln Pro
   1               5                  10                  15    
 Trp His Asn Ala Asp Val Arg Leu Arg Tyr Gly Leu Arg Pro Gly Asn
              20                  25                  30        
 Ala Thr Glu Glu Gly Leu Ala Ser Leu His Ser Val Leu Phe Arg Lys
          35                  40                  45            
 Gln Pro Phe Leu Trp Arg Ala Ala Leu Leu Tyr Tyr Thr Ile His Arg
      50                  55                  60                
 Ala Ala Arg Met Ser Phe Arg Gln Leu Phe Gln Asp Leu Glu Arg Tyr
  65                  70                  75                  80
 Val Gln Asp Ala Asp Val Arg Trp Glu Tyr Cys Val Arg Ala Lys Arg
                  85                  90                  95    
 Gly Gln Thr Asp Thr Ser Leu Pro Gly Cys Phe Ser Lys Asp Gln Val
             100                 105                 110        
 Tyr Leu Asp Gly Ile Val Arg Ile Leu Arg His Arg Gln Thr Ile Asp
         115                 120                 125            
 Phe Pro Leu Leu Thr Ser Leu Gly Lys Val Ser Tyr Glu Asp Val Asp
     130                 135                 140                
 His Leu Arg Pro His Gly Val Leu Asp Asn Thr Arg Val Pro His Phe
 145                 150                 155                 160
 Met Gln Asp Leu Ala Arg Tyr Arg Gln Gln Leu Glu His Ile Met Ala
                 165                 170                 175    
 Thr Asn Arg Leu Asp Glu Ala Glu Leu Gly Arg Leu Leu Pro Asp
             180                 185                 190    



      <210> 1673
      <211> 228
      <212> PRT
      <213> Homo sapiens


      <400> 1673
 Ser Ser Cys Cys Phe Leu Phe Tyr Gly Cys Lys Asn Phe Ser Asp Ile
   1               5                  10                  15    
 Phe Lys Asp Phe Gln Ile Phe Lys Leu Tyr Ser Val Pro Ser Asn Ile
              20                  25                  30        
 Ser Leu Arg Val Asn Phe Ser Phe Tyr Leu Arg Arg Phe Gly Leu Tyr
          35                  40                  45            
 Phe Arg Leu Ser Thr Asn Ala Val Phe Phe Phe Phe Cys His Pro Phe
      50                  55                  60                
 Ile Leu Lys Asp Glu Ala Met Glu Arg Met Ser Gly Lys Ser Ala Cys
  65                  70                  75                  80
 Arg Ser Gly Val Gly Arg Phe Ala Leu Gly Trp Val Ser Arg Trp Val
                  85                  90                  95    
 Glu Val Ser His Pro Asp Glu Glu Pro Pro Asn Ala Thr Lys Leu Val
             100                 105                 110        
 Ala Leu Asn Ile Tyr Leu Gln Val Asp Val Glu Asn His Arg Gly Gln
         115                 120                 125            
 Asn Ile Glu Val Lys Glu Val Leu Ala Gln Pro Pro Gly Gln Val Glu
     130                 135                 140                
 Glu Gly Glu Gln Arg Ala Arg Glu Arg Leu Ala Glu Gly Ala Val Arg
 145                 150                 155                 160
 Ala Ala Gly Pro Leu Arg Ala Arg Gln Pro His Arg Gln Ala Arg Gln
                 165                 170                 175    
 Gly Arg Arg Arg His Gly Pro Asp Ala Ala Ser His Ile Val Pro Arg
             180                 185                 190        
 Ala Gln Gly Leu His Gln Ala Pro Leu Thr His Arg Pro Trp Asp Arg
         195                 200                 205            
 Gly Met Asp Ala Gly Lys Tyr Gly Arg Glu Ala Ser Trp Ala Ala Ala
     210                 215                 220                
 Asp Pro Ser Cys
 225            



      <210> 1674
      <211> 172
      <212> PRT
      <213> Homo sapiens


      <400> 1674
 Met Arg Arg Arg Phe Leu Leu Pro Val His Gly Pro Gln Gln Arg Asn
   1               5                  10                  15    
 Val Cys Phe Trp Gly Leu Asp Gly Gly Leu Leu Ala Glu Leu Glu Thr
              20                  25                  30        
 Phe Phe Arg Thr Asn Arg Asn Ser Arg Arg Ser Gly Trp Val Phe Gln
          35                  40                  45            
 Glu Ser Ala Cys Ala Asp Ala Trp Pro Gln Thr Ala Gly Gln Cys Gln
      50                  55                  60                
 Gln Ala Gly Pro Gln Ala Gln Thr Arg Pro Pro Thr Pro Ile Ser Tyr
  65                  70                  75                  80
 Lys Glu Glu Leu Tyr Arg Cys Leu Tyr Tyr Tyr Cys Leu Arg Tyr Phe
                  85                  90                  95    
 Pro Ala Cys Gly Val Gly Arg Ser Lys Gly Leu Thr Leu Ser Glu Gln
             100                 105                 110        
 Ala Leu Arg Thr Lys Arg Ala Val Ala Trp Arg Ala Arg Ser Gly Arg
         115                 120                 125            
 Ser Ser Ser Val Ala Thr Ser Pro Leu Ala Pro Ala Thr Ala Leu Ala
     130                 135                 140                
 Ala His Ser Arg His Leu Ser Leu Cys Arg Met Pro Lys Asp Leu Phe
 145                 150                 155                 160
 Lys Val Phe Ser Val Thr Pro Thr Val Thr Trp Phe
                 165                 170        



      <210> 1675
      <211> 67
      <212> PRT
      <213> Homo sapiens


      <400> 1675
 Asp Ala Trp Glu Thr Thr Gly Phe Gly Met Ile Tyr Asp Ser Leu Asp
   1               5                  10                  15    
 Tyr Ala Lys Lys Asn Glu Pro Lys His Arg Leu Ala Arg His Gly Leu
              20                  25                  30        
 Tyr Glu Lys Lys Lys Thr Ser Arg Lys Gln Arg Lys Glu Arg Lys Asn
          35                  40                  45            
 Arg Met Lys Lys Val Arg Gly Thr Ala Lys Ala Asn Val Gly Ala Gly
      50                  55                  60                
 Lys Lys Lys
  65        



      <210> 1676
      <211> 348
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(348)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1676
 Pro Phe Gly Tyr Ile Ala Ala Ile Gly Pro Pro Gly Leu Gly Lys Ala
   1               5                  10                  15    
 Ala Gly Phe Val Pro Gly Arg Leu Pro Thr Leu Gly Asn Gly Thr Lys
              20                  25                  30        
 Leu Leu Pro Ala Gly Pro Phe Ile Leu Gly Lys Glu Ala Gly Leu Arg
          35                  40                  45            
 Pro Arg Val Pro Val Gly Leu Val Lys Gly Ala Gly Leu Ile Pro Thr
      50                  55                  60                
 Gly Pro Ala Gly Glu Gly Pro Arg Cys Pro Ala Ala Gly Leu Gly Lys
  65                  70                  75                  80
 Val Thr Xaa Pro Gly Pro Asn Gly Pro Val Asp Leu Gly Lys Val Val
                  85                  90                  95    
 Gly Leu Gly Pro Cys Arg Pro Val Ala Leu Gly Lys Leu Ala Gly Leu
             100                 105                 110        
 Gly Pro Ser Gly Pro Glu Ala Leu Gly Lys Met Val Gly Phe Glu Pro
         115                 120                 125            
 Trp Arg Pro Ala Asp Leu Trp Lys Val Ala Gly Phe Asp Ala Asn Val
     130                 135                 140                
 Pro Glu Asp Xaa Glu Lys Ala Asp Glu Pro Ala Pro Leu Gly Lys Gly
 145                 150                 155                 160
 Leu Ala Phe Thr Pro Met Gly Pro Thr Gly Leu Glu Lys Xaa Ala Glu
                 165                 170                 175    
 Leu Gly Pro Met Gly Pro Gly Ala Leu Asp Met Gly Asp Gly Phe Gly
             180                 185                 190        
 Pro Gly Arg Pro Ile Pro Arg Glu Leu Gly Pro Glu Phe Gly Pro Met
         195                 200                 205            
 Gly Pro Gly Thr Leu Ala Met Glu Asp Gly Leu Val Pro Met Phe Pro
     210                 215                 220                
 Glu Ala Cys Glu Lys Glu Ala Glu Phe Ala Pro Lys Arg Pro Ala Ala
 225                 230                 235                 240
 Leu Arg Met Gly Ala Arg Ser Arg Pro Xaa Gly Pro Ala Ile Leu Lys
                 245                 250                 255    
 Leu Arg Pro Asp Pro Val Pro Lys Arg Pro Pro Ala Leu Ala Ser Arg
             260                 265                 270        
 Leu Gly Pro Gly Pro Arg Pro Leu Gly Leu Gly Leu Gly Pro Arg Pro
         275                 280                 285            
 Gly Pro Gly Asn Thr Pro Asp Leu Gly Ala Gly Phe Val Pro Lys Lys
     290                 295                 300                
 Pro Asp Leu Arg Leu Gly Phe Gly Pro Gly Pro Arg Pro Thr Gly Leu
 305                 310                 315                 320
 Gly Leu Gly Gly Pro Phe Pro Glu Val Asn Arg Thr Pro Ala Leu Arg
                 325                 330                 335    
 Leu Gly Pro Asp Pro Gly Pro Met Gly Pro Pro Pro
             340                 345            



      <210> 1677
      <211> 634
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(634)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1677
 Tyr Leu Gln Arg Gln Cys Arg Leu Val Glu Pro Ile Lys Glu Met Glu
   1               5                  10                  15    
 Val Ser Leu Ser Asp Gly Ala Glu Cys His Gln Val Thr Ser Ala Ser
              20                  25                  30        
 Val Ser Ser His Thr Thr Pro Ser Gln Phe Arg Leu Lys Glu Ser Pro
          35                  40                  45            
 Ala Gly His Thr Trp Leu Ile Cys Thr Gln Glu Lys Arg Ser Val Glu
      50                  55                  60                
 Met Asp Thr Ala Ser Cys Phe His Gln Ser Thr Ser Leu Thr Thr Ala
  65                  70                  75                  80
 Ser Arg Cys Asn Thr Pro Leu Gln Phe Glu Leu Cys His Arg Lys Asp
                  85                  90                  95    
 Leu Asp Leu Ala Lys Val Gly Tyr Leu Asp Ser Asn Thr Asn Ser Cys
             100                 105                 110        
 Ala Asp Arg Pro Val Pro Thr Gln Leu Ser His Ser Asp Leu Ala Pro
         115                 120                 125            
 His Pro Ser Pro Asp Pro Leu Leu Arg Leu Val Ser Gln Ala Glu Val
     130                 135                 140                
 Glu Met Asp Ile Arg Pro Ser Xaa Glu Thr Gln Thr Arg His Phe Gly
 145                 150                 155                 160
 Gln Ser Ser Thr Xaa Cys Met Pro Thr Pro Ser Leu Asn Ala Met Pro
                 165                 170                 175    
 Arg Ala Asp Gly Leu Tyr Arg Gly Ser Pro Leu Val Gly Asp Arg Lys
             180                 185                 190        
 Pro Leu His Leu Asp Gly Gly Tyr Cys Ser Pro Ala Glu Gly Phe Ser
         195                 200                 205            
 Ser Arg Tyr Glu His Gly Leu Met Lys Asp Leu Ser Arg Gly Ser Leu
     210                 215                 220                
 Ser Pro Gly Gly Glu Arg Ala Cys Glu Gly Val Pro Ser Ala Pro Gln
 225                 230                 235                 240
 Asn Pro Pro Gln Arg Lys Lys Val Ser Leu Leu Glu Tyr Arg Lys Arg
                 245                 250                 255    
 Lys Gln Glu Ala Lys Glu Asn Ser Ala Gly Gly Gly Gly Asp Ser Ala
             260                 265                 270        
 Gln Ser Lys Ser Lys Ser Ala Gly Ala Gly Gln Gly Ser Ser Asn Ser
         275                 280                 285            
 Val Ser Asp Thr Gly Ala His Gly Val Gln Gly Ser Ser Ala Arg Thr
     290                 295                 300                
 Pro Ser Ser Pro His Lys Lys Phe Ser Pro Ser His Ser Ser Met Ser
 305                 310                 315                 320
 His Leu Glu Ala Val Ser Pro Ser Asp Ser Arg Gly Thr Ser Ser Ser
                 325                 330                 335    
 His Cys Arg Pro Gln Glu Asn Ile Ser Ser Arg Trp Met Val Pro Thr
             340                 345                 350        
 Ser Val Glu Arg Leu Arg Glu Gly Gly Ser Ile Pro Lys Val Leu Arg
         355                 360                 365            
 Ser Ser Val Arg Val Ala Gln Lys Gly Glu Pro Ser Pro Thr Trp Glu
     370                 375                 380                
 Ser Asn Ile Thr Glu Lys Asp Ser Asp Pro Ala Asp Gly Glu Gly Pro
 385                 390                 395                 400
 Glu Thr Leu Ser Ser Ala Leu Ser Lys Gly Ala Thr Val Tyr Ser Pro
                 405                 410                 415    
 Ser Arg Tyr Ser Tyr Gln Leu Leu Gln Cys Asp Ser Pro Arg Thr Glu
             420                 425                 430        
 Ser Gln Ser Leu Leu Gln Gln Ser Ser Ser Pro Phe Arg Gly His Pro
         435                 440                 445            
 Thr Gln Ser Pro Gly Tyr Ser Tyr Arg Thr Thr Ala Leu Arg Pro Gly
     450                 455                 460                
 Asn Pro Pro Ser His Gly Ser Ser Glu Ser Ser Leu Ser Ser Thr Ser
 465                 470                 475                 480
 Tyr Ser Ser Pro Ala His Pro Val Ser Thr Asp Ser Leu Ala Pro Phe
                 485                 490                 495    
 Thr Gly Thr Pro Gly Tyr Phe Ser Ser Gln Pro His Ser Gly Asn Ser
             500                 505                 510        
 Thr Gly Ser Asn Leu Pro Arg Arg Ser Cys Pro Ser Ser Ala Ala Ser
         515                 520                 525            
 Pro Thr Leu Gln Gly Pro Ser Asp Ser Pro Thr Ser Asp Ser Val Ser
     530                 535                 540                
 Gln Ser Ser Thr Gly Thr Leu Ser Ser Thr Ser Phe Pro Gln Asn Ser
 545                 550                 555                 560
 Arg Ser Ser Leu Pro Ser Asp Leu Arg Thr Ile Ser Leu Pro Ser Ala
                 565                 570                 575    
 Gly Gln Ser Ala Val Tyr Gln Ala Ser Arg Val Ser Ala Val Ser Asn
             580                 585                 590        
 Ser Gln Pro Leu Pro Thr Pro Trp Glu Trp Gly Cys Ala Pro Val Pro
         595                 600                 605            
 Thr Pro Ala Thr Ala Arg Val Arg Ser Gln Asp Ser Asp Gly Thr Phe
     610                 615                 620                
 Leu Gly Leu Leu Asp Leu Gly Lys Gln Asn
 625                 630                



      <210> 1678
      <211> 162
      <212> PRT
      <213> Homo sapiens


      <400> 1678
 Ala Met Glu Tyr Thr Gly Ser Lys Tyr Ile Gly Glu Tyr Val Asp Gly
   1               5                  10                  15    
 Arg Met Glu Gly Lys Ala Arg Tyr Ile Leu Pro Thr Glu Thr Ile Tyr
              20                  25                  30        
 Val Gly Glu Met Lys Asp Gly Met Phe His Gly Glu Gly Thr Leu Tyr
          35                  40                  45            
 Phe Pro Ser Gly Ser Gln Tyr Asp Ala Ile Trp Glu Asn Gly Leu Ala
      50                  55                  60                
 Ile Lys Gly Thr Tyr Thr Phe Ser Asp Gly Leu His Tyr Asp Glu Lys
  65                  70                  75                  80
 Asn Trp His Tyr Cys Asp Gly Tyr Asp Arg Arg Phe Tyr Thr Glu Ile
                  85                  90                  95    
 Leu Asn Gly Leu Lys Pro Ala Gly Met Ala Gln Leu Thr Asn Met Asp
             100                 105                 110        
 Pro Pro Arg Lys Ile Pro Lys Gly Tyr Tyr Asp Cys Gly Asp Gly Phe
         115                 120                 125            
 Tyr Asn Pro Val Thr Arg Val Val Lys Asp Tyr Arg Asn Arg Phe Leu
     130                 135                 140                
 Arg Asn Ala Asp Asp Asp Glu His Glu Trp Ile Thr Arg Thr Cys Arg
 145                 150                 155                 160
 Lys Gly
        



      <210> 1679
      <211> 459
      <212> PRT
      <213> Homo sapiens


      <400> 1679
 His Ala Ser Val Leu Phe Cys Arg Val Met Ala Ala Ser Lys Thr Gln
   1               5                  10                  15    
 Gly Ala Val Ala Arg Met Gln Glu Asp Arg Asp Gly Ser Cys Ser Thr
              20                  25                  30        
 Val Gly Gly Val Gly Tyr Gly Asp Ser Lys Asp Cys Ile Leu Glu Pro
          35                  40                  45            
 Leu Ser Leu Pro Glu Ser Pro Gly Gly Thr Thr Thr Leu Glu Gly Ser
      50                  55                  60                
 Pro Ser Val Pro Cys Ile Phe Cys Glu Glu His Phe Pro Val Ala Glu
  65                  70                  75                  80
 Gln Asp Lys Leu Leu Lys His Met Ile Ile Glu His Lys Ile Val Ile
                  85                  90                  95    
 Ala Asp Val Lys Leu Val Ala Asp Phe Gln Arg Tyr Ile Leu Tyr Trp
             100                 105                 110        
 Arg Lys Arg Phe Thr Glu Gln Pro Ile Thr Asp Phe Cys Ser Val Ile
         115                 120                 125            
 Arg Ile Asn Ser Thr Ala Pro Phe Glu Glu Gln Glu Asn Tyr Phe Leu
     130                 135                 140                
 Leu Cys Asp Val Leu Pro Glu Asp Arg Ile Leu Arg Glu Glu Leu Gln
 145                 150                 155                 160
 Lys Gln Arg Leu Arg Glu Ile Leu Glu Gln Gln Gln Gln Glu Arg Asn
                 165                 170                 175    
 Asp Thr Asn Phe His Gly Val Cys Met Phe Cys Asn Glu Glu Phe Leu
             180                 185                 190        
 Gly Asn Arg Ser Val Ile Leu Asn His Met Ala Arg Glu His Ala Phe
         195                 200                 205            
 Asn Ile Gly Leu Pro Asp Asn Ile Val Asn Cys Asn Glu Phe Leu Cys
     210                 215                 220                
 Thr Leu Gln Lys Lys Leu Asp Asn Leu Gln Cys Leu Tyr Cys Glu Lys
 225                 230                 235                 240
 Thr Phe Arg Asp Lys Asn Thr Leu Lys Asp His Met Arg Lys Lys Gln
                 245                 250                 255    
 His Arg Lys Ile Asn Pro Lys Asn Arg Glu Tyr Asp Arg Phe Tyr Val
             260                 265                 270        
 Ile Asn Tyr Leu Glu Leu Gly Lys Ser Trp Glu Glu Val Gln Leu Glu
         275                 280                 285            
 Asp Asp Arg Glu Leu Leu Asp His Gln Glu Asp Asp Trp Ser Asp Trp
     290                 295                 300                
 Glu Glu His Pro Ala Ser Ala Val Cys Leu Phe Cys Glu Lys Gln Ala
 305                 310                 315                 320
 Glu Thr Ile Glu Lys Leu Tyr Val His Met Glu Asp Ala His Glu Phe
                 325                 330                 335    
 Asp Leu Leu Lys Ile Lys Ser Glu Leu Gly Leu Asn Phe Tyr Gln Gln
             340                 345                 350        
 Val Lys Leu Val Asn Phe Ile Arg Arg Gln Val His Gln Cys Arg Cys
         355                 360                 365            
 Tyr Gly Cys His Val Lys Phe Lys Ser Lys Ala Asp Leu Arg Thr His
     370                 375                 380                
 Met Glu Glu Thr Lys His Thr Ser Leu Leu Pro Asp Arg Lys Thr Trp
 385                 390                 395                 400
 Asp Gln Leu Glu Tyr Tyr Phe Pro Thr Tyr Glu Asn Asp Thr Leu Leu
                 405                 410                 415    
 Trp Thr Leu Ser Asp Ser Glu Ser Asp Leu Thr Ala Gln Glu Gln Asn
             420                 425                 430        
 Glu Asn Val Pro Ile Ile Ser Glu Asp Thr Ser Lys Leu Tyr Ala Leu
         435                 440                 445            
 Lys Gln Ser Ser Ile Leu Asn Gln Leu Leu Leu
     450                 455                



      <210> 1680
      <211> 68
      <212> PRT
      <213> Homo sapiens


      <400> 1680
 Val Leu Pro Trp Ala Pro Asp Gly Gln Gln Cys Ile Arg Val Phe Lys
   1               5                  10                  15    
 Lys Gly Leu Leu Pro Arg Ser Pro Gln Ala Trp Pro Ser Ser Pro Cys
              20                  25                  30        
 Arg Gly Asp Glu Val Ile Ala Val Ala Ser Met Asn Tyr Asp Pro Ile
          35                  40                  45            
 Val Ser Lys Val Ala Glu Val Leu Ala Ser Gly Arg Ala Ile Arg Lys
      50                  55                  60                
 Arg Glu Val Glu
  65            



      <210> 1681
      <211> 627
      <212> PRT
      <213> Homo sapiens


      <400> 1681
 Ser Asn Arg Val Asp Asp Phe Val Cys Glu Ala Pro Cys Gly Gly His
   1               5                  10                  15    
 Leu Thr Ala Ser Ser Gly Val Ile Leu Pro Pro Gly Trp Pro Gly Tyr
              20                  25                  30        
 Tyr Lys Asp Ser Leu His Cys Glu Trp Ile Ile Glu Ala Lys Pro Gly
          35                  40                  45            
 His Ser Ile Lys Ile Thr Phe Asp Arg Phe Gln Thr Glu Val Asn Tyr
      50                  55                  60                
 Asp Thr Leu Glu Val Arg Asp Gly Pro Ala Ser Ser Ser Pro Leu Ile
  65                  70                  75                  80
 Gly Glu Tyr His Gly Thr Gln Ala Pro Gln Phe Leu Ile Ser Thr Gly
                  85                  90                  95    
 Asn Phe Met Tyr Leu Leu Phe Thr Thr Asp Asn Ser Arg Ser Ser Ile
             100                 105                 110        
 Gly Phe Leu Ile His Tyr Glu Ser Val Thr Leu Glu Ser Asp Ser Cys
         115                 120                 125            
 Leu Asp Pro Gly Ile Pro Val Asn Gly His Arg His Gly Gly Asp Phe
     130                 135                 140                
 Gly Ile Arg Ser Thr Val Thr Phe Ser Cys Asp Pro Gly Tyr Thr Leu
 145                 150                 155                 160
 Ser Asp Asp Glu Pro Leu Val Cys Glu Arg Asn His Gln Trp Asn His
                 165                 170                 175    
 Ala Leu Pro Ser Cys Asp Ala Leu Cys Gly Gly Tyr Ile Gln Gly Lys
             180                 185                 190        
 Ser Gly Thr Val Leu Ser Pro Gly Phe Pro Asp Phe Tyr Pro Asn Ser
         195                 200                 205            
 Leu Asn Cys Thr Trp Thr Ile Glu Val Ser His Gly Lys Gly Val Gln
     210                 215                 220                
 Met Ile Phe His Thr Phe His Leu Glu Ser Ser His Asp Tyr Leu Leu
 225                 230                 235                 240
 Ile Thr Glu Asp Gly Ser Phe Ser Glu Pro Val Ala Arg Leu Thr Gly
                 245                 250                 255    
 Ser Val Leu Pro His Thr Ile Lys Ala Gly Leu Phe Gly Asn Phe Thr
             260                 265                 270        
 Ala Gln Leu Arg Phe Ile Ser Asp Phe Ser Ile Ser Tyr Glu Gly Phe
         275                 280                 285            
 Asn Ile Thr Phe Ser Glu Tyr Asp Leu Glu Pro Cys Asp Asp Pro Gly
     290                 295                 300                
 Val Pro Ala Phe Ser Arg Arg Ile Gly Phe His Phe Gly Val Gly Asp
 305                 310                 315                 320
 Ser Leu Thr Phe Ser Cys Phe Leu Gly Tyr Arg Leu Glu Gly Ala Thr
                 325                 330                 335    
 Lys Leu Thr Cys Leu Gly Gly Gly Arg Arg Val Trp Ser Ala Pro Leu
             340                 345                 350        
 Pro Arg Cys Val Ala Glu Cys Gly Ala Ser Val Lys Gly Asn Glu Gly
         355                 360                 365            
 Thr Leu Leu Ser Pro Asn Phe Pro Ser Asn Tyr Asp Asn Asn His Glu
     370                 375                 380                
 Cys Ile Tyr Lys Ile Glu Thr Glu Ala Gly Lys Gly Ile His Leu Arg
 385                 390                 395                 400
 Thr Arg Ser Phe Gln Leu Phe Glu Gly Asp Thr Leu Lys Val Tyr Asp
                 405                 410                 415    
 Gly Lys Asp Ser Ser Ser Arg Pro Leu Gly Thr Phe Thr Lys Asn Glu
             420                 425                 430        
 Leu Leu Gly Leu Ile Leu Asn Ser Thr Ser Asn His Leu Trp Leu Glu
         435                 440                 445            
 Phe Asn Thr Asn Gly Ser Asp Thr Asp Gln Gly Phe Gln Leu Thr Tyr
     450                 455                 460                
 Thr Ser Phe Asp Leu Val Lys Cys Glu Asp Pro Gly Ile Pro Asn Tyr
 465                 470                 475                 480
 Gly Tyr Arg Ile Arg Asp Glu Gly His Phe Thr Asp Thr Val Val Leu
                 485                 490                 495    
 Tyr Ser Cys Asn Pro Gly Tyr Ala Met His Gly Ser Asn Thr Leu Thr
             500                 505                 510        
 Cys Leu Ser Gly Asp Arg Arg Val Trp Asp Lys Pro Leu Pro Ser Cys
         515                 520                 525            
 Ile Ala Glu Cys Gly Gly Gln Ile His Ala Ala Thr Ser Gly Arg Ile
     530                 535                 540                
 Leu Ser Pro Gly Tyr Pro Ala Pro Tyr Asp Asn Asn Leu His Cys Thr
 545                 550                 555                 560
 Trp Ile Ile Glu Ala Asp Pro Gly Lys Thr Ile Ser Leu His Phe Ile
                 565                 570                 575    
 Val Phe Asp Thr Glu Met Ala His Asp Ile Leu Lys Val Trp Asp Gly
             580                 585                 590        
 Pro Val Asp Ser Asp Ile Leu Leu Lys Glu Trp Ser Gly Ser Ala Leu
         595                 600                 605            
 Pro Glu Asp Ile His Ser Thr Phe Asn Ser Leu Thr Leu Gln Phe Asp
     610                 615                 620                
 Ser Val Tyr
 625        



      <210> 1682
      <211> 803
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(803)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1682
 Met Leu Ala Ser Ser Lys Arg Met Asn Ser Ser Ser Arg Ser Gln Ile
   1               5                  10                  15    
 Leu Leu Arg Trp Lys Ser Asp Lys Ala Gln Ser Gly Pro Tyr Asn Val
              20                  25                  30        
 Glu Lys Glu Ile Leu Thr Ser Arg Phe Leu Arg Asp Thr Glu Thr Cys
          35                  40                  45            
 Arg Gln Asn Phe Arg Asn Phe Pro Tyr Pro Asp Leu Ala Gly Pro Arg
      50                  55                  60                
 Lys Ala Leu Ser Gln Leu Arg Glu Leu Cys Leu Lys Trp Leu Arg Pro
  65                  70                  75                  80
 Glu Ile His Ser Lys Glu Gln Ile Leu Glu Leu Leu Val Leu Glu Gln
                  85                  90                  95    
 Phe Leu Thr Ile Leu Pro Gly Glu Val Arg Thr Trp Val Lys Ser Gln
             100                 105                 110        
 Tyr Pro Glu Ser Ser Glu Glu Ala Val Thr Leu Val Glu Asp Leu Thr
         115                 120                 125            
 Gln Ile Leu Glu Glu Glu Ala Pro Gln Asn Ser Thr Leu Ser Gln Asp
     130                 135                 140                
 Pro Gln Arg Lys Thr Pro Glu Glu Asn Met Leu Ser Arg Gln Asp Gly
 145                 150                 155                 160
 Xaa Met Thr Trp Xaa Pro Gln Glu Ser Met Thr Phe Lys Asp Val Ala
                 165                 170                 175    
 Val Asp Ile Thr Gln Glu Asp Trp Glu Leu Met Arg Pro Val Gln Lys
             180                 185                 190        
 Glu Leu Tyr Lys Thr Val Thr Leu Gln Asn Tyr Trp Asn Met Val Ser
         195                 200                 205            
 Leu Glu Thr Tyr Ser Val Gln Thr Asn Cys Asp Ser His Ile Gly Arg
     210                 215                 220                
 Thr Met Asp Gly Asp Lys Arg Asn Phe Arg Arg Pro Xaa Ser Arg Met
 225                 230                 235                 240
 Gly Asn Xaa Ser Pro Ser Met Tyr Cys Gln Trp Arg Ile Met Ser Asn
                 245                 250                 255    
 Leu Thr Lys Glu Glu Thr His Thr Ile Lys Leu Glu Asp Ser Tyr Asp
             260                 265                 270        
 Tyr Asp Asp Arg Leu Glu Arg Arg Gly Lys Gly Gly Phe Trp Lys Ile
         275                 280                 285            
 His Thr Asp Glu Arg Gly Phe Ser Leu Lys Ser Val Leu Ser Gln Glu
     290                 295                 300                
 Tyr Asp Pro Thr Glu Glu Cys Leu Ser Lys Tyr Asp Ile Tyr Arg Asn
 305                 310                 315                 320
 Asn Phe Glu Lys His Ser Asn Leu Ile Ile Gln Tyr Arg Tyr Pro Ile
                 325                 330                 335    
 Arg Xaa Xaa Asn Phe Leu Cys Asn Asn Glu Gly Arg Ala Thr Phe Asn
             340                 345                 350        
 His Val Ser Tyr Gly Ile Val His Arg Lys Ile Leu Pro Gly Glu Lys
         355                 360                 365            
 Pro Tyr Lys Cys Asn Val Cys Gly Lys Lys Phe Arg Lys Tyr Pro Ser
     370                 375                 380                
 Leu Leu Lys His Gln Ser Thr His Ala Lys Glu Lys Ser Tyr Glu Cys
 385                 390                 395                 400
 Glu Glu Cys Gly Lys Glu Phe Arg His Ile Ser Ser Leu Ile Ala His
                 405                 410                 415    
 Gln Arg Met His Thr Gly Glu Lys Pro Tyr Glu Cys His Gln Cys Gly
             420                 425                 430        
 Lys Ala Phe Ser Gln Arg Ala His Leu Thr Ile His Gln Arg Ile His
         435                 440                 445            
 Thr Gly Glu Lys Pro Tyr Lys Cys Asp Asp Cys Gly Lys Asp Phe Ser
     450                 455                 460                
 Gln Arg Ala His Leu Thr Ile His Gln Arg Thr His Thr Gly Glu Lys
 465                 470                 475                 480
 Pro Tyr Lys Cys Leu Glu Cys Gly Lys Thr Phe Ser His Ser Ser Ser
                 485                 490                 495    
 Leu Ile Asn His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Ile Cys
             500                 505                 510        
 Asn Glu Cys Gly Lys Thr Phe Ser Gln Ser Thr His Leu Leu Gln His
         515                 520                 525            
 Gln Lys Ile His Thr Gly Lys Lys Pro Tyr Lys Cys Asn Glu Cys Trp
     530                 535                 540                
 Lys Val Phe Ser Gln Ser Thr Tyr Leu Ile Arg His Gln Arg Ile His
 545                 550                 555                 560
 Ser Gly Glu Lys Cys Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Ala
                 565                 570                 575    
 His Ser Ser Thr Leu Ile Gln His Gln Thr Thr His Thr Gly Glu Lys
             580                 585                 590        
 Ser Tyr Ile Cys Asn Ile Cys Gly Lys Ala Phe Ser Gln Ser Ala Asn
         595                 600                 605            
 Leu Thr Gln His His Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys
     610                 615                 620                
 Ser Val Cys Gly Lys Ala Phe Ser Gln Ser Val His Leu Thr Gln His
 625                 630                 635                 640
 Gln Arg Ile His Asn Gly Glu Lys Pro Phe Lys Cys Asn Ile Cys Gly
                 645                 650                 655    
 Lys Ala Tyr Arg Gln Gly Ala Asn Leu Thr Gln His Gln Arg Ile His
             660                 665                 670        
 Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Ile
         675                 680                 685            
 Tyr Ser Ser Ser Leu Asn Gln His Gln Arg Thr His Thr Gly Glu Arg
     690                 695                 700                
 Pro Tyr Lys Cys Asn Glu Cys Asp Lys Asp Phe Ser Gln Arg Thr Cys
 705                 710                 715                 720
 Leu Ile Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Ala Cys
                 725                 730                 735    
 Arg Ile Cys Gly Lys Thr Phe Thr Gln Ser Thr Asn Leu Ile Gln His
             740                 745                 750        
 Gln Arg Val His Thr Glu Arg Asn Pro Val Lys Gly Ile Gln Lys His
         755                 760                 765            
 Asn Ser Ser Thr Leu Tyr Phe Lys Tyr Thr Tyr Pro Leu Val Tyr Ser
     770                 775                 780                
 Gly Asp Trp Phe Gln Asp His Pro Cys Ile Arg Lys Ser Thr His Thr
 785                 790                 795                 800
 Gln Val Ala
            



      <210> 1683
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 1683
 Gly Val Leu Arg Ser Ala Trp Arg Gly Phe Pro Pro Lys Gln Asp Cys
   1               5                  10                  15    
 Asn Ile Gln Glu Lys Ile Asp Leu Glu Ile Arg Met Arg Glu Gly Ile
              20                  25                  30        
 Trp Lys Leu Leu Ser Leu Ser Thr Gln Lys Asp Gln Val Leu His Ala
          35                  40                  45            
 Val Lys Asn Leu Met Gly Cys Asn Ala Arg Leu Met Ala Tyr Thr Ser
      50                  55                  60                
 Glu Leu Gln Lys Leu Glu Glu Gln Ile Ala Asn His Thr Gly Arg Cys
  65                  70                  75                  80
 Asp Val Lys Phe Glu Ser Lys Glu Arg Thr Ala Cys Lys Gly Lys Ile
                  85                  90                  95    
 Ala Ile Ser Asp Ile Arg Ile Pro Leu Met Trp Lys Asp Ser Asp His
             100                 105                 110        
 Phe Ser Asn Lys Glu Arg Ser Arg Arg Tyr Ala Ile Phe Cys Leu Phe
         115                 120                 125            
 Lys Met Gly Ala Asn Val Phe Asp Thr Asp Val Val Asn Val Asp Lys
     130                 135                 140                
 Thr Ile Thr Asp Ile Cys Phe Glu Asn Val Thr Ile Leu
 145                 150                 155        



      <210> 1684
      <211> 193
      <212> PRT
      <213> Homo sapiens


      <400> 1684
 Phe Leu Phe Lys Asn Leu His Gly Ile Asn Ile Tyr Arg Arg Lys Lys
   1               5                  10                  15    
 Gly Asn Ser Lys Met Lys Pro Gly Glu Tyr Ser Ser Ser Val Ile Ser
              20                  25                  30        
 Phe Val Asn Gly Gln Phe Leu Gly Asp Ala Leu Asp Leu Gln Lys Trp
          35                  40                  45            
 Ala His Glu Val Trp Asp Ile Val Asp Ile Lys Pro Ser Ala Leu Tyr
      50                  55                  60                
 Asp Ala Leu Thr Glu Asp Phe Ser Ala Lys Phe Leu Arg Asp Thr Lys
  65                  70                  75                  80
 His Asp Phe Val Phe Leu Asp Ile Cys Ile Asp Ser Ser Pro Ile Gly
                  85                  90                  95    
 Arg Leu Ile Phe Glu Leu Tyr Cys Asp Val Cys Pro Lys Thr Cys Lys
             100                 105                 110        
 Asn Phe Gln Val Leu Cys Thr Gly Lys Ala Gly Phe Ser Gln Arg Gly
         115                 120                 125            
 Ile Arg Leu His Tyr Lys Asn Ser Ile Phe His Arg Ile Val Gln Asn
     130                 135                 140                
 Gly Trp Ile Gln Gly Gly Asp Ile Val Tyr Gly Lys Gly Asp Asn Gly
 145                 150                 155                 160
 Glu Ser Ile Tyr Gly Pro Thr Phe Glu Asp Glu Asn Phe Ser Val Pro
                 165                 170                 175    
 His Asn Lys Arg Gly Val Leu Gly Met Ala Asn Lys Gly Arg His Ser
             180                 185                 190        
 Ser
    



      <210> 1685
      <211> 257
      <212> PRT
      <213> Homo sapiens


      <400> 1685
 Arg Val Arg Met Arg Arg Asn Ala Glu Val Ile Glu Glu Lys Leu Ser
   1               5                  10                  15    
 Met Lys Ser Trp Ala Lys Phe Arg Pro Gly Glu Pro Trp Lys Gly Tyr
              20                  25                  30        
 Pro Asn Ile Asp Pro Glu Thr Asp Pro Tyr Val Thr Pro Gly Ser Val
          35                  40                  45            
 Ile Asn Asn Leu Ser Ile Asn Thr Val Arg Glu Val Asp His Leu Arg
      50                  55                  60                
 Asp Arg Asn Ser Gly Ser Ser Ser Ser Leu Asn Thr Thr Leu Pro Ser
  65                  70                  75                  80
 Thr Ser Ala Trp Ser Ser Ile Arg Ala Ser Asn Tyr Asn Val Pro Leu
                  85                  90                  95    
 Ser Ser Thr Ala Gln Ser Thr Ser Ala Arg Asn Ser Asp Ser Lys Leu
             100                 105                 110        
 Thr Trp Ser Pro Gly Ser Val Thr Asn Thr Ser Leu Ala His Glu Leu
         115                 120                 125            
 Trp Lys Val Pro Leu Pro Pro Lys Asn Ile Thr Ala Pro Ser Arg Pro
     130                 135                 140                
 Pro Pro Gly Leu Thr Gly Gln Lys Pro Pro Leu Ser Thr Trp Asp Asn
 145                 150                 155                 160
 Ser Pro Leu Arg Ile Gly Gly Gly Trp Gly Asn Ser Asp Ala Arg Tyr
                 165                 170                 175    
 Thr Pro Gly Ser Ser Trp Gly Glu Ser Ser Ser Gly Arg Ile Thr Asn
             180                 185                 190        
 Trp Leu Val Leu Lys Asn Leu Thr Pro Gln Ile Asp Gly Ser Thr Leu
         195                 200                 205            
 Arg Thr Leu Cys Met Gln His Gly Pro Leu Ile Thr Phe His Leu Asn
     210                 215                 220                
 Leu Pro His Gly Asn Ala Leu Val Arg Tyr Ser Ser Lys Glu Glu Val
 225                 230                 235                 240
 Val Lys Ala Gln Lys Ser Leu His Ile Ser Asp Leu Phe Leu Leu Thr
                 245                 250                 255    
 Leu
    



      <210> 1686
      <211> 257
      <212> PRT
      <213> Homo sapiens


      <400> 1686
 Arg Val Arg Met Arg Arg Asn Ala Glu Val Ile Glu Glu Lys Leu Ser
   1               5                  10                  15    
 Met Lys Ser Trp Ala Lys Phe Arg Pro Gly Glu Pro Trp Lys Gly Tyr
              20                  25                  30        
 Pro Asn Ile Asp Pro Glu Thr Asp Pro Tyr Val Thr Pro Gly Ser Val
          35                  40                  45            
 Ile Asn Asn Leu Ser Ile Asn Thr Val Arg Glu Val Asp His Leu Arg
      50                  55                  60                
 Asp Arg Asn Ser Gly Ser Ser Ser Ser Leu Asn Thr Thr Leu Pro Ser
  65                  70                  75                  80
 Thr Ser Ala Trp Ser Ser Ile Arg Ala Ser Asn Tyr Asn Val Pro Leu
                  85                  90                  95    
 Ser Ser Thr Ala Gln Ser Thr Ser Ala Arg Asn Ser Asp Ser Lys Leu
             100                 105                 110        
 Thr Trp Ser Pro Gly Ser Val Thr Asn Thr Ser Leu Ala His Glu Leu
         115                 120                 125            
 Trp Lys Val Pro Leu Pro Pro Lys Asn Ile Thr Ala Pro Ser Arg Pro
     130                 135                 140                
 Pro Pro Gly Leu Thr Gly Gln Lys Pro Pro Leu Ser Thr Trp Asp Asn
 145                 150                 155                 160
 Ser Pro Leu Arg Ile Gly Gly Gly Trp Gly Asn Ser Asp Ala Arg Tyr
                 165                 170                 175    
 Thr Pro Gly Ser Ser Trp Gly Glu Ser Ser Ser Gly Arg Ile Thr Asn
             180                 185                 190        
 Trp Leu Val Leu Lys Asn Leu Thr Pro Gln Ile Asp Gly Ser Thr Leu
         195                 200                 205            
 Arg Thr Leu Cys Met Gln His Gly Pro Leu Ile Thr Phe His Leu Asn
     210                 215                 220                
 Leu Pro His Gly Asn Ala Leu Val Arg Tyr Ser Ser Lys Glu Glu Val
 225                 230                 235                 240
 Val Lys Ala Gln Lys Ser Leu His Ile Ser Asp Leu Phe Leu Leu Thr
                 245                 250                 255    
 Leu
    



      <210> 1687
      <211> 257
      <212> PRT
      <213> Homo sapiens


      <400> 1687
 Arg Val Arg Met Arg Arg Asn Ala Glu Val Ile Glu Glu Lys Leu Ser
   1               5                  10                  15    
 Met Lys Ser Trp Ala Lys Phe Arg Pro Gly Glu Pro Trp Lys Gly Tyr
              20                  25                  30        
 Pro Asn Ile Asp Pro Glu Thr Asp Pro Tyr Val Thr Pro Gly Ser Val
          35                  40                  45            
 Ile Asn Asn Leu Ser Ile Asn Thr Val Arg Glu Val Asp His Leu Arg
      50                  55                  60                
 Asp Arg Asn Ser Gly Ser Ser Ser Ser Leu Asn Thr Thr Leu Pro Ser
  65                  70                  75                  80
 Thr Ser Ala Trp Ser Ser Ile Arg Ala Ser Asn Tyr Asn Val Pro Leu
                  85                  90                  95    
 Ser Ser Thr Ala Gln Ser Thr Ser Ala Arg Asn Ser Asp Ser Lys Leu
             100                 105                 110        
 Thr Trp Ser Pro Gly Ser Val Thr Asn Thr Ser Leu Ala His Glu Leu
         115                 120                 125            
 Trp Lys Val Pro Leu Pro Pro Lys Asn Ile Thr Ala Pro Ser Arg Pro
     130                 135                 140                
 Pro Pro Gly Leu Thr Gly Gln Lys Pro Pro Leu Ser Thr Trp Asp Asn
 145                 150                 155                 160
 Ser Pro Leu Arg Ile Gly Gly Gly Trp Gly Asn Ser Asp Ala Arg Tyr
                 165                 170                 175    
 Thr Pro Gly Ser Ser Trp Gly Glu Ser Ser Ser Gly Arg Ile Thr Asn
             180                 185                 190        
 Trp Leu Val Leu Lys Asn Leu Thr Pro Gln Ile Asp Gly Ser Thr Leu
         195                 200                 205            
 Arg Thr Leu Cys Met Gln His Gly Pro Leu Ile Thr Phe His Leu Asn
     210                 215                 220                
 Leu Pro His Gly Asn Ala Leu Val Arg Tyr Ser Ser Lys Glu Glu Val
 225                 230                 235                 240
 Val Lys Ala Gln Lys Ser Leu His Ile Ser Asp Leu Phe Leu Leu Thr
                 245                 250                 255    
 Leu
    



      <210> 1688
      <211> 349
      <212> PRT
      <213> Homo sapiens


      <400> 1688
 Phe Arg Val Gly Met Glu Ala Ser Trp Arg Arg Val Ala Gly Gly Arg
   1               5                  10                  15    
 Gly Arg Ser Arg Gly Arg Ala Thr Ala Ala Pro Ser Gly Asn Gly Val
              20                  25                  30        
 His Leu Arg Gly Ala Gly Gly Gly Arg Glu Lys Gly Ser Val Gly Ala
          35                  40                  45            
 Val Pro Ser Gly Thr Ser Pro Gly Gly Val Ala Thr Thr Ala Ala Ala
      50                  55                  60                
 Gly Ser Arg His Ser Pro Ala Gly Ser Gln Ala Leu Gln Thr Thr Ala
  65                  70                  75                  80
 Ala Ser Glu Leu Met Ser Gln Lys Lys Phe Glu Glu Ile Lys Lys Ala
                  85                  90                  95    
 Asn Gln Ala Ala Ala Arg Lys Leu Val Glu Glu Gln Phe Ser Ser Ser
             100                 105                 110        
 Ser Glu Glu Gly Asp Glu Asp Phe Glu Gly Lys Gln Gly Lys Ile Leu
         115                 120                 125            
 Ala Asn Thr Phe Ile Thr Tyr Thr Ala Gln Thr Gly Ser Ser Gly Asp
     130                 135                 140                
 Pro Ser Asp Ala Val Ser Cys Thr His Phe Pro Thr Ser Pro Asn Glu
 145                 150                 155                 160
 Met Asn Gln Val Pro His Leu Glu Met Gln Lys Ser Pro Ala Glu Ile
                 165                 170                 175    
 Thr Tyr Leu Gln Lys Cys Arg Ser His Ile Ser Ala Glu Met Gln Lys
             180                 185                 190        
 Ser His Ile Cys Arg Asn Ala Glu Val Thr Tyr Leu Gln Lys Cys Arg
         195                 200                 205            
 Ser His Ile Ser Ala Glu Met Gln Lys Ser Arg Phe Cys Arg Asn Ala
     210                 215                 220                
 Glu Val Thr Tyr Leu Gln Lys Cys Arg Ser His Val Ser Ala Glu Met
 225                 230                 235                 240
 Gln Lys Ser His Ile Cys Arg Asn Ala Glu Val Thr Phe Leu Gln Lys
                 245                 250                 255    
 Cys Arg Ser His Val Ser Ala Glu Met Gln Lys Ser Arg Phe Cys Arg
             260                 265                 270        
 Asn Ala Glu Val Thr Phe Leu Gln Lys Cys Arg Ser His Val Ser Ala
         275                 280                 285            
 Glu Met Gln Lys Ser Arg Ile Cys Arg Asn Ala Glu Val Thr Phe Leu
     290                 295                 300                
 Gln Lys Cys Arg Asn His Leu Ser Ser Val Leu Ile Ser Leu Gly Ala
 305                 310                 315                 320
 Val Asp Gln Ser Cys Ser Tyr Ser Ala Thr Pro Pro Ser Lys Gln Phe
                 325                 330                 335    
 Leu Ile Gln His Thr Ser Arg Ala Arg Ile Ala Asn Gly
             340                 345                



      <210> 1689
      <211> 147
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(147)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1689
 Phe Arg Leu Pro Trp Ser Tyr Phe Trp Met Thr Ile Ile Cys Phe Cys
   1               5                  10                  15    
 Glu Glu Glu Trp Asp Gly Gln Xaa Glu Ser Ala Xaa Ile Gly Leu Arg
              20                  25                  30        
 Asp Ser Gln Arg Ser Asp Pro Arg Pro Phe Leu Gly Met His Ile Met
          35                  40                  45            
 Leu Val Gln Arg Gln Met Ser Val Ile Glu Glu Asp Leu Glu Glu Phe
      50                  55                  60                
 Gln Leu Ala Leu Lys His Tyr Val Glu Ser Ala Ser Ser Gln Ser Gly
  65                  70                  75                  80
 Cys Leu Arg Ile Ser Ile Gln Lys Leu Ser Asn Glu Ser Arg Tyr Met
                  85                  90                  95    
 Ile Tyr Glu Phe Trp Glu Asn Ser Ser Val Trp Asn Ser His Leu Gln
             100                 105                 110        
 Thr Asn Tyr Ser Lys Thr Phe Gln Arg Ser Asn Val Asp Phe Leu Glu
         115                 120                 125            
 Thr Pro Glu Leu Thr Ser Thr Met Leu Val Pro Ala Ser Trp Trp Ile
     130                 135                 140                
 Leu Asn Asn
 145        



      <210> 1690
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 1690
 Val Asp Pro Arg Val Arg Pro Tyr Arg Arg Gln Thr Tyr Asp Leu Tyr
   1               5                  10                  15    
 Arg Leu Ala Ala Leu Ala Gly Pro Val Gly Val Gly Leu Asn Glu Leu
              20                  25                  30        
 Lys Arg Lys Leu Leu Ile Ser Asp Thr Gln His Tyr Gly Val Thr Val
          35                  40                  45            
 Pro His Thr Thr Arg Ala Arg Arg Ser Gln Glu Ser Asp Gly Val Glu
      50                  55                  60                
 Tyr Ile Phe Ile Ser Lys His Leu Phe Glu Thr Asp Val Gln Asn Asn
  65                  70                  75                  80
 Lys Phe Ile Glu Tyr Gly Glu Tyr Lys Asn Asn Tyr Tyr Gly Thr Ser
                  85                  90                  95    
 Ile Asp Ser Val Arg Ser Val Leu Ala Lys Asn Lys Val Trp Leu Leu
             100                 105                 110        
 Asp Val Gln Pro His Thr Val Lys His Leu Arg Thr Leu Glu Phe Lys
         115                 120                 125            
 Pro Tyr Val Ile Phe
     130            



      <210> 1691
      <211> 72
      <212> PRT
      <213> Homo sapiens


      <400> 1691
 Ile Trp Gly Lys Val Glu Lys Leu Phe Val Phe Phe Ala Val Pro Pro
   1               5                  10                  15    
 Asn Gly Leu Val Val Tyr Cys Gly Thr Ile Val Thr Glu Glu Gly Lys
              20                  25                  30        
 Glu Lys Lys Val Asn Ile Asp Phe Glu Pro Phe Lys Pro Ile Asn Thr
          35                  40                  45            
 Ser Leu Tyr Leu Cys Asp Asn Lys Phe His Thr Glu Val Arg Ser Gln
      50                  55                  60                
 Thr Gln Asn Ile Phe Ile Ala Pro
  65                  70        



      <210> 1692
      <211> 236
      <212> PRT
      <213> Homo sapiens


      <400> 1692
 Met Pro Lys Gly Lys Glu Ala Lys Gly Lys Lys Leu Ala Leu Ala Pro
   1               5                  10                  15    
 Ala Phe Val Lys Lys Gln Glu Ala Lys Lys Val Val Asn Pro Leu Phe
              20                  25                  30        
 Glu Lys Arg Pro Lys Asn Phe Gly Ile Gly Gln Asp Ile Gln Pro Lys
          35                  40                  45            
 Arg Asp Leu Thr Cys Phe Val Lys Trp Pro Arg Tyr Ile Arg Leu Gln
      50                  55                  60                
 Trp Gln Arg Ser Ile Leu Tyr Lys Gln Leu Lys Pro Glu Thr Lys Gln
  65                  70                  75                  80
 Glu Lys Lys Trp Arg Leu Leu Ala Gln Ala Glu Ser Val Gly Lys Gly
                  85                  90                  95    
 Asp Leu Pro Met Lys Arg Leu Pro Val Phe Arg Ala Gly Val Asn Thr
             100                 105                 110        
 Val Thr Thr Phe Val Asp Asn Lys Lys Ala Pro Leu Val Val Thr Thr
         115                 120                 125            
 His Asp Met Asp Pro Ile Glu Leu Thr Val Phe Leu Pro Val Leu Cys
     130                 135                 140                
 His Lys Met Gly Ala Thr Cys Cys Ile Ile Lys Gly Lys Ala Arg Leu
 145                 150                 155                 160
 Gly Cys Leu Val His Arg Lys Thr Tyr Thr Thr Val Asp Phe Thr Gln
                 165                 170                 175    
 Val Asn Ser Glu Asp Lys Gly Ala Leu Ala Lys Leu Val Glu Ala Ile
             180                 185                 190        
 Gly Thr Asn Tyr Asn Ala Arg Tyr Asp Glu Thr His Cys His Trp Asp
         195                 200                 205            
 Gly Asn Val Leu Gly Pro Lys Ser Val Ala His Ile Ala Lys Leu Glu
     210                 215                 220                
 Lys Ala Lys Ala Lys Glu Leu Ala Thr Lys Leu Gly
 225                 230                 235    



      <210> 1693
      <211> 232
      <212> PRT
      <213> Homo sapiens


      <400> 1693
 Gly Ile Pro His Leu Ser Ser Arg Asp Met Thr Gly Thr Pro Gly Ala
   1               5                  10                  15    
 Val Ala Thr Arg Asp Gly Glu Ala Pro Glu Arg Ser Pro Pro Cys Ser
              20                  25                  30        
 Pro Ser Tyr Asp Leu Thr Gly Lys Val Met Leu Leu Gly Asp Thr Gly
          35                  40                  45            
 Val Gly Lys Thr Cys Phe Leu Ile Gln Phe Lys Asp Gly Ala Phe Leu
      50                  55                  60                
 Ser Gly Thr Phe Ile Ala Thr Val Gly Ile Asp Phe Arg Asn Lys Val
  65                  70                  75                  80
 Val Thr Val Asp Gly Val Arg Val Lys Leu Gln Ile Trp Asp Thr Ala
                  85                  90                  95    
 Gly Gln Glu Arg Phe Arg Ser Val Thr His Ala Tyr Tyr Arg Asp Ala
             100                 105                 110        
 Gln Ala Leu Leu Leu Leu Tyr Asp Ile Thr Asn Lys Ser Ser Phe Asp
         115                 120                 125            
 Asn Ile Arg Ala Trp Leu Thr Glu Ile His Glu Tyr Ala Gln Arg Asp
     130                 135                 140                
 Val Val Ile Met Leu Leu Gly Asn Lys Ala Asp Met Ser Ser Glu Arg
 145                 150                 155                 160
 Val Ile Arg Ser Glu Asp Gly Glu Thr Leu Ala Arg Glu Tyr Gly Val
                 165                 170                 175    
 Pro Phe Leu Glu Thr Ser Ala Lys Thr Gly Met Asn Val Glu Leu Ala
             180                 185                 190        
 Phe Leu Ala Ile Ala Lys Glu Leu Lys Tyr Arg Ala Gly His Gln Ala
         195                 200                 205            
 Asp Glu Pro Ser Phe Gln Ile Arg Asp Tyr Val Glu Ser Gln Lys Lys
     210                 215                 220                
 Arg Ser Ser Cys Cys Ser Phe Met
 225                 230        



      <210> 1694
      <211> 132
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(132)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1694
 Pro Trp Pro Ser Pro Val Leu Gln Gly Gly Gln Pro Gly Gly Arg Pro
   1               5                  10                  15    
 Arg Ala Arg Ser Ala Gly Pro Pro Gly Xaa Cys Xaa Val Leu Gly Pro
              20                  25                  30        
 Cys Gly Gln Thr Pro Ser Pro Pro Gly Ala Pro Pro Ser Val Ala Lys
          35                  40                  45            
 Gln Cys His Gln Leu Val Ala Gln Pro Gln Leu Arg Leu Ala Tyr Ala
      50                  55                  60                
 Arg Ser His Cys Gln Gly His Gly Pro Gly Pro Gly Arg Arg Thr Gln
  65                  70                  75                  80
 Leu Ser Pro Ala Pro Arg Pro Arg Arg Arg Arg Cys Leu Gln Pro Pro
                  85                  90                  95    
 Gln Thr Ala Pro Ala Pro Gly Trp Gly Arg Leu Cys Thr Gly Pro Arg
             100                 105                 110        
 Ser Val Pro Pro Gly Cys Arg Gly Pro Pro Cys Xaa Ser Ala Ala Arg
         115                 120                 125            
 Cys Asn Arg Ser
     130        



      <210> 1695
      <211> 581
      <212> PRT
      <213> Homo sapiens


      <400> 1695
 Met Arg Leu Gly Phe Glu Ser Arg Gly Glu Ile Ala Lys Asp Gln Ala
   1               5                  10                  15    
 Lys Leu Asp Leu Ala Gly Gln Lys Glu Arg Asp Asn Gln Ser Ser Thr
              20                  25                  30        
 Leu Gly Glu Ala Glu Thr Pro Leu Ile Ile Cys Trp Ser Thr Leu Glu
          35                  40                  45            
 Asp Pro His Tyr Asp Val Ile Val Ile Asp Ser Ala Pro Asn Leu Gly
      50                  55                  60                
 Ile Gly Thr Ile Asn Val Val Cys Ala Ala Asp Val Leu Ile Val Pro
  65                  70                  75                  80
 Thr Pro Ala Glu Leu Phe Asp Tyr Thr Ser Ala Leu Gln Phe Phe Asp
                  85                  90                  95    
 Met Leu Arg Asp Leu Leu Lys Asn Val Asp Leu Lys Gly Phe Glu Pro
             100                 105                 110        
 Asp Val Arg Ile Leu Leu Thr Lys Tyr Ser Asn Ser Asn Gly Ser Gln
         115                 120                 125            
 Ser Pro Trp Met Glu Glu Gln Ile Arg Asp Ala Trp Gly Ser Met Val
     130                 135                 140                
 Leu Lys Asn Val Val Arg Glu Thr Asp Glu Val Gly Lys Ala Ala Pro
 145                 150                 155                 160
 Met Val Asp Ser Leu Ile Ala Arg Val Gly Val Met Ala Arg Gly Asn
                 165                 170                 175    
 Ala Ile Thr Leu Pro Val Cys Gly Arg Asp Val Lys Phe Thr Leu Glu
             180                 185                 190        
 Val Leu Arg Gly Asp Ser Val Glu Lys Thr Ser Arg Val Trp Ser Gly
         195                 200                 205            
 Asn Glu Arg Asp Gln Glu Leu Leu Thr Glu Asp Ala Leu Asp Asp Leu
     210                 215                 220                
 Ile Pro Ser Phe Leu Leu Thr Gly Gln Gln Thr Pro Ala Phe Gly Arg
 225                 230                 235                 240
 Arg Val Ser Leu Tyr Pro Leu Ala Gly Gly Ala Thr Gln Ala Phe Ala
                 245                 250                 255    
 Lys Glu Asn Asn Gln Lys Ala Tyr Lys Glu Thr Tyr Gly Val Ser His
             260                 265                 270        
 Ile Thr Arg His Asp Met Leu Gln Ile Pro Lys Gln Gln Gln Asn Glu
         275                 280                 285            
 Lys Tyr Gln Val Pro Gln Phe Asp Gln Ser Thr Ile Lys Asn Ile Glu
     290                 295                 300                
 Ser Ala Lys Gly Leu Asp Val Trp Asp Ser Trp Pro Leu Gln Asn Ala
 305                 310                 315                 320
 Asp Gly Thr Val Ala Glu Tyr Asn Gly Tyr His Val Val Phe Ala Leu
                 325                 330                 335    
 Ala Gly Ser Pro Lys Asp Ala Asp Asp Thr Ser Ile Tyr Met Phe Tyr
             340                 345                 350        
 Gln Lys Val Gly Asp Asn Ser Ile Asp Ser Trp Lys Asn Ala Gly Arg
         355                 360                 365            
 Val Phe Lys Asp Ser Asp Lys Phe Asp Ala Asn Asp Pro Ile Leu Lys
     370                 375                 380                
 Asp Gln Thr Gln Glu Trp Ser Gly Ser Ala Thr Phe Thr Ser Asp Gly
 385                 390                 395                 400
 Lys Ile Arg Leu Phe Tyr Thr Asp Tyr Ser Gly Lys His Tyr Gly Lys
                 405                 410                 415    
 Gln Ser Leu Thr Thr Ala Gln Val Asn Val Ser Lys Ser Asp Asp Thr
             420                 425                 430        
 Leu Lys Ile Asn Gly Val Glu Asp His Lys Thr Ile Phe Asp Gly Asp
         435                 440                 445            
 Gly Lys Thr Tyr Gln Asn Val Gln Gln Phe Ile Asp Glu Gly Asn Tyr
     450                 455                 460                
 Thr Ser Gly Asp Asn His Thr Leu Arg Asp Pro His Tyr Val Glu Asp
 465                 470                 475                 480
 Lys Gly His Lys Tyr Leu Val Phe Glu Ala Asn Thr Gly Thr Glu Asn
                 485                 490                 495    
 Gly Tyr Gln Gly Glu Glu Ser Leu Phe Asn Lys Ala Tyr Tyr Gly Gly
             500                 505                 510        
 Gly Thr Asn Phe Phe Pro Cys Arg Gly Arg Leu Ala Ala Thr Arg Leu
         515                 520                 525            
 Ala Gly Pro Glu Arg Gln Pro Arg Gly Gly Asp Gly Val Ala Pro Arg
     530                 535                 540                
 Gln Arg Arg Phe Cys Gly Arg Leu Glu Val Gly Ser Gly Arg Glu Lys
 545                 550                 555                 560
 Glu Glu Gly Lys Arg Gly Trp Ala Ser Ala Ser Gly Ala Ala Val Pro
                 565                 570                 575    
 Phe Val Ser Ala Ala
             580    



      <210> 1696
      <211> 527
      <212> PRT
      <213> Homo sapiens


      <400> 1696
 Met Ser Arg Ala Ala Ala Ala Ala Gly Pro Pro Arg Gln Ala Thr Pro
   1               5                  10                  15    
 Ala Ser Pro Arg Trp Ser Asn Asp Cys Val Leu Arg Arg Glu Cys Ser
              20                  25                  30        
 Asn Pro Ile Gly His Thr Leu Gln His Tyr Pro Gly Arg Tyr Gln Asp
          35                  40                  45            
 His Val Gln Leu Glu Ile Pro Asn Arg Val Leu Asn Ser Pro Val Thr
      50                  55                  60                
 Lys Thr Pro Ser Arg Asp Pro Pro Thr Thr Ser Gly Val Thr Ser Pro
  65                  70                  75                  80
 Ala Ser Asp Glu Pro Pro Ala Asp Ile Gln Thr Ala Gln Asn Ser Arg
                  85                  90                  95    
 Gln Val Val Lys Gly Gln Ser Leu Thr Trp Thr Ser Lys Gly Leu Ala
             100                 105                 110        
 Met Arg Arg Lys Gly Ser Arg Asp Leu Val Val Asp Ser Ala Lys Ser
         115                 120                 125            
 Leu Glu Asp Gly Pro Ser Ala Ala Leu His Ser Lys Leu Tyr Glu Ala
     130                 135                 140                
 Ile Met Arg Glu Asp Cys Thr Thr Ile Glu Val Leu Leu Arg Asn His
 145                 150                 155                 160
 Pro Val Asn Gln Pro Ile Thr Ile Leu Pro Asn Ser Ala Ser Asn Arg
                 165                 170                 175    
 Leu Leu Leu Thr Gln Pro Thr Glu Ser Ile Ile Pro Ile His Leu Ala
             180                 185                 190        
 Ala Lys Tyr His Lys Ala Gln Ser Leu Leu Cys Leu Leu Arg His Gly
         195                 200                 205            
 Ala Asp Pro Glu Val Arg Asp Thr Thr Gly Leu Thr Thr Leu Asn Leu
     210                 215                 220                
 Met Leu Leu His Trp Pro Val Thr Ser Thr Thr Trp Ala Lys Pro Gly
 225                 230                 235                 240
 Asn Arg Thr His Arg Ile Leu Thr Asp Ile Gln Asn Ser Ser Ile Thr
                 245                 250                 255    
 Cys Leu Arg Ile Leu Cys Ala His Gly Ala Gln Val Asn Thr Gln Gly
             260                 265                 270        
 Glu Ile Ser Asn Lys Arg Ser Pro Leu His Leu Ala Ile Ala Tyr Gly
         275                 280                 285            
 Cys Tyr Pro Val Leu Ser Ile Leu Thr Gln Asn Gly Ala Asp Val Asn
     290                 295                 300                
 Ala Ile Asn Glu Ala Ser Met Thr Pro Leu His Met Ala Ala Asn Met
 305                 310                 315                 320
 Leu Asn Lys Glu Met Met Glu Thr Leu Ile Ala Tyr Gly Ala Asn Val
                 325                 330                 335    
 Asn Cys Ala Val Ser Ser Thr Gly Asn Thr Pro Leu Lys Leu Ala Val
             340                 345                 350        
 Cys Thr Ala Ser Ser Lys Ala Gly Arg Leu Leu Gly Ala Gly Val Ser
         355                 360                 365            
 Cys Ile Arg Leu Leu Leu Thr His Gly Ala Lys Val Asn Ala Gln Asp
     370                 375                 380                
 Tyr Lys Gly Gln Thr Ala Ile His Glu Ala Cys Phe Gly Gly Arg Glu
 385                 390                 395                 400
 Ala Ile Ile Asn Leu Leu Leu Glu Phe Glu Ala Asn Val Asn Ile Leu
                 405                 410                 415    
 Thr Arg Asn Gly Glu Ser Pro Ile Tyr Met Tyr Leu Gln Arg Ser Cys
             420                 425                 430        
 Asn Val Arg Asp Thr Ala Leu Leu Ala Arg Leu Leu Tyr His Thr Tyr
         435                 440                 445            
 Pro Leu Arg Met Thr Asn Asn Gln Gly Ile Leu Pro Ala Gly Ile Met
     450                 455                 460                
 Leu Pro Glu Phe Arg Leu Leu Arg Asp Thr Leu Ile Lys Gln Ser Gln
 465                 470                 475                 480
 Lys Pro Leu Ser Leu Gln Gly Ile Cys Gln Arg Asn Ile Arg Asn Ile
                 485                 490                 495    
 Tyr Gly Glu Lys Tyr Lys Gln Pro Leu Lys Gln Phe Leu Pro Val Thr
             500                 505                 510        
 Ile Trp Asn Ser Val Tyr Cys Trp Tyr Asp Leu Ala Tyr Thr Ser
         515                 520                 525        



      <210> 1697
      <211> 365
      <212> PRT
      <213> Homo sapiens


      <400> 1697
 Trp Asn Ala Val Val Ser Asn Arg Ser Cys Arg Val Asp Pro Arg Val
   1               5                  10                  15    
 Arg Gly Arg Val Gly Gly Cys Gly Gly Val Gln Arg Ala Val Arg Leu
              20                  25                  30        
 Ala Arg Arg Arg Arg Gly Arg Arg Thr Arg Ser Arg Gln Arg Gly Arg
          35                  40                  45            
 Leu Gly Ser Pro Gly Ala Pro Gln Gln Glu Asp Ala Met Asp Asp Lys
      50                  55                  60                
 Glu Leu Ile Glu Tyr Phe Lys Ser Gln Met Lys Glu Asp Pro Asp Met
  65                  70                  75                  80
 Ala Ser Ala Val Ala Ala Ile Arg Thr Leu Leu Glu Phe Leu Lys Arg
                  85                  90                  95    
 Asp Lys Gly Glu Thr Ile Gln Gly Leu Arg Ala Asn Leu Thr Ser Ala
             100                 105                 110        
 Ile Glu Thr Leu Cys Gly Val Asp Ser Ser Val Ala Val Ser Ser Gly
         115                 120                 125            
 Gly Glu Leu Phe Leu Arg Phe Ile Ser Leu Ala Ser Leu Glu Tyr Ser
     130                 135                 140                
 Asp Tyr Ser Lys Cys Lys Lys Ile Met Ile Glu Arg Gly Glu Leu Phe
 145                 150                 155                 160
 Leu Arg Arg Ile Ser Leu Ser Arg Asn Lys Ile Ala Asp Leu Cys His
                 165                 170                 175    
 Thr Phe Ile Lys Asp Gly Ala Thr Ile Leu Thr His Ala Tyr Ser Arg
             180                 185                 190        
 Val Val Leu Arg Val Leu Glu Ala Ala Val Ala Ala Lys Lys Arg Phe
         195                 200                 205            
 Ser Val Tyr Val Thr Glu Ser Gln Pro Asp Leu Ser Gly Lys Lys Met
     210                 215                 220                
 Ala Lys Ala Leu Cys His Leu Asn Val Pro Val Thr Val Val Leu Asp
 225                 230                 235                 240
 Ala Ala Val Gly Tyr Ile Met Glu Lys Ala Asp Leu Val Ile Val Gly
                 245                 250                 255    
 Ala Glu Gly Val Val Glu Asn Gly Gly Ile Ile Asn Lys Ile Gly Thr
             260                 265                 270        
 Asn Gln Met Ala Val Cys Ala Lys Ala Gln Asn Lys Pro Phe Tyr Val
         275                 280                 285            
 Val Ala Glu Ser Phe Lys Phe Val Arg Leu Phe Pro Leu Asn Gln Gln
     290                 295                 300                
 Asp Val Pro Asp Lys Phe Lys Tyr Lys Ala Asp Thr Leu Lys Val Ala
 305                 310                 315                 320
 Gln Thr Gly Gln Asp Leu Lys Glu Glu His Pro Trp Val Asp Tyr Thr
                 325                 330                 335    
 Ala Pro Ser Leu Ile Thr Leu Leu Phe Thr Asp Leu Gly Val Leu Thr
             340                 345                 350        
 Pro Ser Ala Val Ser Asp Glu Leu Ile Lys Leu Tyr Leu
         355                 360                 365



      <210> 1698
      <211> 265
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(265)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1698
 Cys Ser Gly Ser Pro Pro Thr Cys Arg Gln Ala Gln Thr Ser Leu Glu
   1               5                  10                  15    
 Val Ala Leu Tyr Met Phe Leu Gln Asn Pro Asp Thr Glu Ala Val Leu
              20                  25                  30        
 Val Ala Met Ser Cys Phe Cys His Leu Cys Glu Glu Ala Asp Thr Gln
          35                  40                  45            
 Cys Gly Val Asp Glu Val Ser Val His Asn Leu Leu Pro Asn Ser Asn
      50                  55                  60                
 Thr Phe Met Glu Phe Ala Cys Gln Gln Cys Asp Val Asn Ser Pro Pro
  65                  70                  75                  80
 Val Gly Pro Val Ser Glu His Lys Gly Ser Met Ile Ser Val Met Ser
                  85                  90                  95    
 Ser Glu Gly Asn Ala Asp Thr Pro Val Ser Lys Tyr Met Asp Gln Leu
             100                 105                 110        
 Leu Ser Leu Met Val Cys Asn Leu Glu Lys Val Gly Leu Gln Ile Pro
         115                 120                 125            
 Thr Asn Asp Lys Asp Leu Val Leu Leu Thr Asp Thr Asn Thr Gln Phe
     130                 135                 140                
 Val Glu Gln Thr Leu Asp Ile Met Lys Asn Leu Leu Asp Asn His Thr
 145                 150                 155                 160
 Glu Gly Ser Pro Glu His Leu Glu Gln Ala Ser Ile Glu Thr Met Met
                 165                 170                 175    
 Leu Asn Leu Val Arg Asn Lys Met Val Glu Tyr Leu Thr Asp Trp Val
             180                 185                 190        
 Met Gly Thr Ser Asn Gln Ala Ala Asp Asp Asp Val Lys Cys Leu Thr
         195                 200                 205            
 Ser Arg Ile Asp His Pro Gly Gly Thr Leu Leu Xaa Gly Gln Pro Arg
     210                 215                 220                
 Pro Glu Leu Pro Ala Gly Leu Pro Arg Gln Pro Ala Ser Pro Gly Pro
 225                 230                 235                 240
 Arg His Pro Gly Ala Ser Cys Gly Trp Pro Arg Ala Pro Pro Asp Ser
                 245                 250                 255    
 Ala Pro Gly Gly Pro Gly Arg Glu Arg
             260                 265



      <210> 1699
      <211> 290
      <212> PRT
      <213> Homo sapiens


      <400> 1699
 Thr Glu Gly Gln Lys Asn Leu Ile Val Glu Val Thr Ser Asn Asp Ala
   1               5                  10                  15    
 Val Arg Phe Tyr Pro Trp Thr Ile Asp Asn Lys Tyr Tyr Ser Ala Asp
              20                  25                  30        
 Ile Asn Leu Cys Val Val Pro Asn Lys Phe Leu Val Thr Ala Glu Ile
          35                  40                  45            
 Ala Glu Ser Val Gln Ala Phe Val Val Tyr Phe Asp Ser Thr Gln Lys
      50                  55                  60                
 Ser Gly Leu Asp Ser Val Ser Ser Trp Leu Pro Leu Ala Lys Ala Trp
  65                  70                  75                  80
 Leu Pro Glu Val Met Ile Leu Val Cys Asp Arg Val Ser Glu Asp Gly
                  85                  90                  95    
 Ile Asn Arg Gln Lys Ala Gln Glu Trp Cys Ile Lys His Gly Phe Glu
             100                 105                 110        
 Leu Val Glu Leu Ser Pro Glu Glu Leu Pro Glu Glu Asp Asp Asp Phe
         115                 120                 125            
 Pro Glu Ser Thr Gly Val Lys Arg Ile Val Gln Ala Leu Asn Ala Asn
     130                 135                 140                
 Val Trp Ser Asn Val Val Met Lys Asn Asp Arg Asn Gln Gly Phe Ser
 145                 150                 155                 160
 Leu Leu Asn Ser Leu Thr Gly Thr Asn His Ser Ile Gly Ser Ala Asp
                 165                 170                 175    
 Pro Cys His Pro Glu Gln Pro His Leu Pro Ala Ala Asp Ser Thr Glu
             180                 185                 190        
 Ser Leu Ser Asp His Arg Gly Gly Ala Ser Asn Thr Thr Asp Ala Gln
         195                 200                 205            
 Val Asp Ser Ile Val Asp Pro Met Leu Asp Leu Asp Ile Gln Glu Leu
     210                 215                 220                
 Ala Ser Leu Thr Thr Gly Gly Gly Asp Val Glu Asn Phe Glu Arg Leu
 225                 230                 235                 240
 Phe Ser Lys Leu Lys Glu Met Arg Asp Lys Ala Ala Thr Leu Pro His
                 245                 250                 255    
 Glu Gln Arg Lys Val His Ala Glu Lys Val Ala Lys Ala Phe Trp Met
             260                 265                 270        
 Ala Ile Gly Gly Asp Arg Asp Glu Ile Glu Gly Leu Ser Ser Asp Glu
         275                 280                 285            
 Glu His
     290



      <210> 1700
      <211> 30
      <212> PRT
      <213> Homo sapiens


      <400> 1700
 Leu Lys Thr Val Asp Lys Phe Asn Glu Trp Phe Val Ser Ala Phe Val
   1               5                  10                  15    
 Thr Ala Gly His Ile Leu Thr Phe Leu Val Lys Val Thr Asn
              20                  25                  30



      <210> 1701
      <211> 384
      <212> PRT
      <213> Homo sapiens


      <400> 1701
 Pro Pro Ala Thr Ser Gln Ala Ala Leu Pro Glu Ala Leu Ser Lys Gly
   1               5                  10                  15    
 Arg Glu Thr Pro Arg Pro Ala Thr His Pro Ala Arg Ser Gln Asp Val
              20                  25                  30        
 Arg Pro Leu Ser Cys Pro Phe Asp Phe Leu Arg Asp Asn Val Glu Trp
          35                  40                  45            
 Ser Glu Glu Gln Ala Ala Ala Ala Glu Arg Lys Val Gln Glu Asn Ser
      50                  55                  60                
 Ile Gln Arg Val Cys Gln Glu Lys Gln Val Asp Tyr Glu Ile Asn Ala
  65                  70                  75                  80
 His Lys Tyr Trp Asn Asp Phe Tyr Lys Ile His Glu Asn Gly Phe Phe
                  85                  90                  95    
 Lys Asp Arg His Trp Leu Phe Thr Glu Phe Pro Glu Leu Ala Pro Ser
             100                 105                 110        
 Gln Asn Gln Asn His Leu Lys Asp Trp Phe Leu Glu Asn Lys Ser Glu
         115                 120                 125            
 Val Pro Glu Cys Arg Asn Asn Glu Asp Gly Pro Gly Leu Ile Met Glu
     130                 135                 140                
 Glu Gln His Lys Cys Ser Ser Lys Ser Leu Glu His Lys Thr Gln Thr
 145                 150                 155                 160
 Pro Pro Val Glu Glu Asn Val Thr Gln Lys Ile Ser Asp Leu Glu Ile
                 165                 170                 175    
 Cys Ala Asp Glu Phe Pro Gly Ser Ser Ala Thr Tyr Arg Ile Leu Glu
             180                 185                 190        
 Val Gly Cys Gly Val Gly Asn Thr Val Phe Pro Ile Leu Gln Thr Asn
         195                 200                 205            
 Asn Asp Pro Gly Leu Phe Val Tyr Cys Cys Asp Phe Ser Ser Thr Ala
     210                 215                 220                
 Ile Glu Leu Val Gln Thr Asn Ser Glu Tyr Asp Pro Ser Arg Cys Phe
 225                 230                 235                 240
 Ala Phe Val His Asp Leu Cys Asp Glu Glu Lys Ser Tyr Pro Val Pro
                 245                 250                 255    
 Lys Gly Ser Leu Asp Ile Ile Ile Leu Ile Phe Val Leu Ser Ala Ile
             260                 265                 270        
 Val Pro Asp Lys Met Gln Lys Ala Ile Asn Arg Leu Ser Arg Leu Leu
         275                 280                 285            
 Lys Pro Gly Gly Met Val Leu Leu Arg Asp Tyr Gly Arg Tyr Asp Met
     290                 295                 300                
 Ala Gln Leu Arg Phe Lys Lys Gly Gln Cys Leu Ser Gly Asn Phe Tyr
 305                 310                 315                 320
 Val Arg Gly Asp Gly Thr Arg Val Tyr Phe Phe Thr Gln Glu Glu Leu
                 325                 330                 335    
 Asp Thr Leu Phe Thr Thr Ala Gly Leu Glu Lys Val Gln Asn Leu Val
             340                 345                 350        
 Asp Arg Arg Leu Gln Val Asn Arg Gly Lys Gln Leu Thr Met Tyr Arg
         355                 360                 365            
 Val Trp Ile Gln Cys Lys Tyr Cys Lys Pro Leu Leu Ser Ser Thr Ser
     370                 375                 380                





      <210> 1702
      <211> 134
      <212> PRT
      <213> Homo sapiens


      <400> 1702
 Phe Val Gly Gly Pro Gly Ala Asp Pro Pro Val Ala Val Met Trp Asp
   1               5                  10                  15    
 Pro Arg Ala Ala Arg Met Asp Leu Thr Ala Tyr Ala Glu Leu Leu Lys
              20                  25                  30        
 Glu Ser Gly Asn Gln Val Leu Lys Asn Gly Asn Phe Ser Leu Ala Ile
          35                  40                  45            
 Arg Lys Tyr Asp Glu Ala Ile Gln Ile Leu Leu Gln Leu Tyr Gln Trp
      50                  55                  60                
 Gly Val Pro Pro Arg Asp Leu Ala Val Leu Leu Cys Asn Lys Ser Asn
  65                  70                  75                  80
 Ala Phe Phe Ser Leu Gly Lys Trp Asn Glu Ala Phe Val Ala Ala Lys
                  85                  90                  95    
 Glu Cys Leu Gln Trp Asp Pro Thr Tyr Val Lys Gly Tyr Tyr Arg Ala
             100                 105                 110        
 Gly Tyr Ser Leu Leu Arg Leu His Gln Pro Tyr Glu Ala Ala Arg Met
         115                 120                 125            
 Phe Phe Glu Gly Leu Arg
     130                



      <210> 1703
      <211> 681
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(681)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1703
 Glu Gly Glu Thr Thr Cys Val Leu His Ile Ser Gln Gln Pro Thr Xaa
   1               5                  10                  15    
 Met Xaa Ser Val Pro Gln Arg Glu Gln Val Ser Xaa Thr Phe Pro Phe
              20                  25                  30        
 Tyr Val Gln His Ser Ala Glu Gln Ile Thr Ala Leu Cys Arg Ser Phe
          35                  40                  45            
 Asn Asp Ser Gln Ala Asn Gly Met Glu Gly Pro Arg Glu Asn Gln Asp
      50                  55                  60                
 Pro Pro Pro Arg Pro Leu Ala Arg His Leu Ser Asp Ala Asp Arg Leu
  65                  70                  75                  80
 Arg Lys Val Ile Gln Glu Leu Val Asp Thr Glu Lys Ser Tyr Val Lys
                  85                  90                  95    
 Asp Leu Ser Cys Leu Phe Glu Leu Tyr Leu Glu Pro Leu Gln Asn Glu
             100                 105                 110        
 Thr Phe Leu Thr Gln Asp Glu Met Glu Ser Leu Phe Gly Ser Leu Pro
         115                 120                 125            
 Glu Met Leu Glu Phe Gln Lys Val Phe Leu Glu Thr Leu Glu Asp Gly
     130                 135                 140                
 Ile Ser Ala Ser Ser Asp Phe Asn Thr Leu Glu Thr Pro Ser Gln Phe
 145                 150                 155                 160
 Arg Lys Leu Leu Phe Ser Leu Gly Gly Ser Phe Leu Tyr Tyr Ala Asp
                 165                 170                 175    
 His Phe Lys Leu Tyr Ser Gly Phe Cys Ala Asn His Ile Lys Val Gln
             180                 185                 190        
 Lys Val Leu Glu Arg Ala Lys Thr Asp Lys Ala Phe Lys Ala Phe Leu
         195                 200                 205            
 Asp Ala Arg Asn Pro Thr Lys Gln His Ser Ser Thr Leu Glu Ser Tyr
     210                 215                 220                
 Leu Ile Lys Pro Val Gln Arg Val Leu Lys Tyr Pro Leu Leu Leu Lys
 225                 230                 235                 240
 Glu Leu Val Ser Leu Thr Asp Gln Glu Ser Glu Glu His Tyr His Leu
                 245                 250                 255    
 Thr Glu Ala Leu Lys Ala Met Glu Lys Val Ala Ser His Ile Asn Glu
             260                 265                 270        
 Met Gln Lys Ile Tyr Glu Asp Tyr Gly Thr Val Phe Asp Gln Leu Val
         275                 280                 285            
 Ala Glu Gln Ser Gly Thr Glu Lys Glu Val Thr Glu Leu Ser Met Gly
     290                 295                 300                
 Glu Leu Leu Met His Ser Thr Val Ser Trp Leu Asn Pro Phe Leu Ser
 305                 310                 315                 320
 Leu Gly Lys Ala Arg Lys Asp Leu Glu Leu Thr Val Phe Val Phe Lys
                 325                 330                 335    
 Arg Ala Val Ile Leu Val Tyr Lys Glu Asn Cys Lys Leu Lys Lys Lys
             340                 345                 350        
 Leu Pro Ser Asn Ser Arg Pro Ala His Asn Ser Thr Asp Leu Asp Pro
         355                 360                 365            
 Phe Lys Phe Arg Trp Leu Ile Pro Ile Ser Ala Leu Gln Val Arg Leu
     370                 375                 380                
 Gly Asn Pro Ala Gly Thr Glu Asn Asn Ser Ile Trp Glu Leu Ile His
 385                 390                 395                 400
 Thr Lys Ser Glu Ile Glu Gly Arg Pro Glu Thr Ile Phe Gln Leu Cys
                 405                 410                 415    
 Cys Ser Asp Ser Glu Ser Lys Thr Asn Ile Val Lys Val Ile Arg Ser
             420                 425                 430        
 Ile Leu Arg Glu Asn Phe Arg Arg His Ile Lys Cys Glu Leu Pro Leu
         435                 440                 445            
 Glu Lys Thr Cys Lys Asp Arg Leu Val Pro Leu Lys Asn Arg Val Pro
     450                 455                 460                
 Val Ser Ala Lys Leu Ala Ser Ser Arg Ser Leu Lys Val Leu Lys Asn
 465                 470                 475                 480
 Ser Ser Ser Asn Glu Trp Thr Gly Glu Thr Gly Lys Gly Thr Leu Leu
                 485                 490                 495    
 Asp Ser Asp Glu Gly Ser Leu Ser Ser Gly Thr Gln Ser Ser Gly Cys
             500                 505                 510        
 Pro Thr Ala Glu Gly Arg Gln Asp Ser Lys Ser Thr Ser Pro Gly Lys
         515                 520                 525            
 Tyr Pro His Pro Gly Leu Ala Asp Phe Ala Asp Asn Leu Ile Lys Glu
     530                 535                 540                
 Ser Asp Ile Leu Ser Asp Glu Asp Asp Asp His Arg Gln Thr Val Lys
 545                 550                 555                 560
 Gln Gly Ser Pro Thr Lys Asp Ile Glu Ile Gln Phe Gln Arg Leu Arg
                 565                 570                 575    
 Ile Ser Glu Asp Pro Asp Val His Pro Glu Ala Glu Gln Gln Pro Gly
             580                 585                 590        
 Pro Glu Ser Gly Glu Gly Gln Lys Gly Gly Glu Gln Pro Lys Leu Val
         595                 600                 605            
 Arg Gly His Phe Cys Pro Ile Lys Arg Lys Ala Asn Ser Thr Lys Arg
     610                 615                 620                
 Asp Arg Gly Thr Leu Leu Lys Ala Gln Ile Arg His Gln Ser Leu Asp
 625                 630                 635                 640
 Ser Gln Ser Glu Asn Ala Thr Ile Asp Leu Asn Ser Val Leu Glu Arg
                 645                 650                 655    
 Glu Phe Ser Val Gln Ser Leu Thr Ser Val Val Ser Glu Glu Cys Phe
             660                 665                 670        
 Tyr Glu Thr Glu Ser His Gly Lys Ser
         675                 680    



      <210> 1704
      <211> 334
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(334)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1704
 Thr Pro Thr Thr Ser Gly Arg Thr Arg Lys Met Trp Pro Arg Pro Gly
   1               5                  10                  15    
 Thr Xaa Pro Pro Ala Asn Cys Ser Ala Asn Ile Asn Leu Thr His Gln
              20                  25                  30        
 Pro Trp Phe Gln Val Leu Glu Pro Gln Phe Arg Gln Phe Leu Phe Tyr
          35                  40                  45            
 Arg His Cys Arg Tyr Phe Pro Met Leu Leu Asn His Pro Glu Lys Cys
      50                  55                  60                
 Arg Gly Asp Val Tyr Leu Leu Val Val Val Lys Ser Val Ile Thr Gln
  65                  70                  75                  80
 His Asp Arg Arg Glu Ala Ile Arg Gln Thr Trp Ala Arg Ala Ala Val
                  85                  90                  95    
 Arg Gly Trp Gly Pro Ser Ala Val Arg Thr Leu Phe Leu Leu Gly Thr
             100                 105                 110        
 Ala Ser Lys Gln Glu Glu Arg Thr His Tyr Gln Gln Leu Leu Ala Tyr
         115                 120                 125            
 Glu Asp Ala Leu Tyr Gly Asp Ile Leu Gln Trp Gly Phe Leu Asp Thr
     130                 135                 140                
 Phe Phe Asn Leu Thr Leu Lys Glu Ile His Phe Leu Lys Trp Leu Asp
 145                 150                 155                 160
 Ile Tyr Cys Pro His Val Pro Phe Ile Phe Lys Gly Asp Asp Asp Val
                 165                 170                 175    
 Phe Val Asn Pro Thr Asn Leu Leu Glu Phe Leu Ala Asp Arg Gln Pro
             180                 185                 190        
 Gln Glu Asn Leu Phe Val Gly Asp Val Leu Gln His Ala Arg Pro Ile
         195                 200                 205            
 Arg Arg Lys Asp Asn Lys Tyr Tyr Ile Pro Gly Ala Leu Tyr Gly Lys
     210                 215                 220                
 Ala Ser Tyr Pro Pro Tyr Ala Gly Gly Gly Gly Phe Leu Met Ala Gly
 225                 230                 235                 240
 Ser Leu Ala Arg Arg Leu His His Ala Cys Asp Thr Leu Glu Leu Tyr
                 245                 250                 255    
 Pro Ile Asp Asp Val Phe Leu Gly Met Cys Leu Glu Val Leu Gly Val
             260                 265                 270        
 Gln Pro Thr Ala His Glu Gly Phe Lys Thr Phe Gly Ile Ser Arg Asn
         275                 280                 285            
 Arg Asn Ser Arg Met Asn Lys Glu Pro Cys Phe Phe Arg Ala Met Leu
     290                 295                 300                
 Val Val His Lys Leu Leu Pro Pro Glu Leu Leu Ala Met Trp Gly Leu
 305                 310                 315                 320
 Val His Ser Asn Leu Thr Cys Ser Arg Lys Leu Gln Val Leu
                 325                 330                



      <210> 1705
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 1705
 Pro Gly Ser Ser Arg Ser Asp Gly Gly Asp Ile Asp Pro Asp Ser Gly
   1               5                  10                  15    
 Ser Ser Arg Ser Asp Gly Gly Asp Met Val Pro Asp Ser Gly Ser Ser
              20                  25                  30        
 Gln Ser Asp Glu Gly Asp Met Val Pro Asp Ser Gly Ser Ser Gln Ser
          35                  40                  45            
 Asp Glu Gly Asp Met Val Pro Asp Ser Gly Ser Ser Arg Ser Asp Gly
      50                  55                  60                
 Gly Asp Ile Asp Pro Asp Ser Gly Ser Ser Gln Ser Asp Gly Gly Asp
  65                  70                  75                  80
 Met Val Pro Asp Ser Gly Ser Ser Gln Ser Asp Gly Gly Asn Met Val
                  85                  90                  95    
 Pro Asp Ser Gly Ser Ser Gln Ser Asp Gly Gly Asp Thr Asp Pro Pro
             100                 105                 110        
 Ser Trp Ser Ser Gln Ser Asp Glu Gly Asp Ile Val Pro Asp Ser Gly
         115                 120                 125            
 Ser
    



      <210> 1706
      <211> 93
      <212> PRT
      <213> Homo sapiens


      <400> 1706
 Met Lys Ile Ser Met Ile Asn Tyr Lys Ser Leu Leu Ala Leu Leu Phe
   1               5                  10                  15    
 Ile Leu Ala Ser Trp Ile Ile Phe Thr Val Phe Gln Asn Ser Thr Lys
              20                  25                  30        
 Val Trp Ser Ala Leu Asn Leu Ser Ile Ser Leu His Tyr Trp Asn Asn
          35                  40                  45            
 Ser Thr Lys Ser Leu Phe Pro Lys Thr Pro Leu Ile Ser Leu Lys Pro
      50                  55                  60                
 Leu Thr Glu Thr Glu Leu Arg Ile Lys Glu Ile Ile Glu Lys Leu Asp
  65                  70                  75                  80
 Gln Gln Ile Pro Pro Arg Pro Phe Thr His Val Asn Thr
                  85                  90            



      <210> 1707
      <211> 229
      <212> PRT
      <213> Homo sapiens


      <400> 1707
 Ser Ala Gly Phe Ser Arg Pro Leu Ala Ala Pro Gly Val Met Tyr Gly
   1               5                  10                  15    
 Ser Gln Lys Gly Thr Thr Phe Thr Lys Ile Phe Val Gly Gly Leu Pro
              20                  25                  30        
 Tyr His Thr Thr Asp Ala Ser Leu Arg Lys Tyr Phe Glu Gly Phe Gly
          35                  40                  45            
 Asp Ile Glu Glu Ala Val Val Ile Thr Asp Arg Gln Thr Gly Lys Ser
      50                  55                  60                
 Arg Gly Tyr Gly Phe Val Thr Met Ala Asp Arg Ala Ala Ala Glu Arg
  65                  70                  75                  80
 Ala Cys Lys Asp Pro Asn Pro Ile Ile Asp Gly Arg Lys Ala Asn Val
                  85                  90                  95    
 Asn Leu Ala Tyr Leu Gly Ala Lys Pro Arg Ser Leu Gln Thr Gly Phe
             100                 105                 110        
 Ala Ile Gly Val Gln Gln Leu His Pro Thr Leu Ile Gln Arg Thr Tyr
         115                 120                 125            
 Gly Leu Thr Pro His Tyr Ile Tyr Pro Pro Ala Ile Val Gln Pro Ser
     130                 135                 140                
 Val Val Ile Pro Ala Ala Pro Val Pro Ser Leu Ser Ser Pro Tyr Ile
 145                 150                 155                 160
 Glu Tyr Thr Pro Ala Ser Pro Ala Tyr Ala Gln Tyr Pro Pro Ala Thr
                 165                 170                 175    
 Tyr Asp Gln Tyr Pro Tyr Ala Ala Ser Pro Ala Thr Ala Ala Ser Phe
             180                 185                 190        
 Val Gly Tyr Ser Tyr Pro Ala Ala Val Pro Gln Ala Leu Ser Ala Ala
         195                 200                 205            
 Ala Pro Ala Gly Thr Thr Phe Val Gln Tyr Gln Ala Pro Gln Leu Gln
     210                 215                 220                
 Pro Asp Arg Met Gln
 225                



      <210> 1708
      <211> 229
      <212> PRT
      <213> Homo sapiens


      <400> 1708
 Ser Ala Gly Phe Ser Arg Pro Leu Ala Ala Pro Gly Val Met Tyr Gly
   1               5                  10                  15    
 Ser Gln Lys Gly Thr Thr Phe Thr Lys Ile Phe Val Gly Gly Leu Pro
              20                  25                  30        
 Tyr His Thr Thr Asp Ala Ser Leu Arg Lys Tyr Phe Glu Gly Phe Gly
          35                  40                  45            
 Asp Ile Glu Glu Ala Val Val Ile Thr Asp Arg Gln Thr Gly Lys Ser
      50                  55                  60                
 Arg Gly Tyr Gly Phe Val Thr Met Ala Asp Arg Ala Ala Ala Glu Arg
  65                  70                  75                  80
 Ala Cys Lys Asp Pro Asn Pro Ile Ile Asp Gly Arg Lys Ala Asn Val
                  85                  90                  95    
 Asn Leu Ala Tyr Leu Gly Ala Lys Pro Arg Ser Leu Gln Thr Gly Phe
             100                 105                 110        
 Ala Ile Gly Val Gln Gln Leu His Pro Thr Leu Ile Gln Arg Thr Tyr
         115                 120                 125            
 Gly Leu Thr Pro His Tyr Ile Tyr Pro Pro Ala Ile Val Gln Pro Ser
     130                 135                 140                
 Val Val Ile Pro Ala Ala Pro Val Pro Ser Leu Ser Ser Pro Tyr Ile
 145                 150                 155                 160
 Glu Tyr Thr Pro Ala Ser Pro Ala Tyr Ala Gln Tyr Pro Pro Ala Thr
                 165                 170                 175    
 Tyr Asp Gln Tyr Pro Tyr Ala Ala Ser Pro Ala Thr Ala Ala Ser Phe
             180                 185                 190        
 Val Gly Tyr Ser Tyr Pro Ala Ala Val Pro Gln Ala Leu Ser Ala Ala
         195                 200                 205            
 Ala Pro Ala Gly Thr Thr Phe Val Gln Tyr Gln Ala Pro Gln Leu Gln
     210                 215                 220                
 Pro Asp Arg Met Gln
 225                



      <210> 1709
      <211> 371
      <212> PRT
      <213> Homo sapiens


      <400> 1709
 Lys Leu Pro Trp Glu Pro Ser Phe Leu Ile Lys Met Gln Ile Ile Arg
   1               5                  10                  15    
 His Ser Glu Gln Thr Leu Lys Thr Ala Leu Ile Ser Lys Asn Pro Val
              20                  25                  30        
 Leu Val Ser Gln Tyr Glu Lys Leu Asp Ala Gly Glu Gln Arg Leu Met
          35                  40                  45            
 Asn Glu Ala Phe Gln Pro Ala Ser Asp Leu Phe Gly Pro Ile Thr Leu
      50                  55                  60                
 His Ser Pro Ser Asp Trp Ile Thr Ser His Pro Glu Ala Pro Gln Asp
  65                  70                  75                  80
 Phe Glu Gln Phe Phe Ser Asp Pro Tyr Arg Lys Thr Pro Ser Pro Asn
                  85                  90                  95    
 Lys Arg Ser Ile Tyr Ile Gln Ser Ile Gly Ser Leu Gly Asn Thr Arg
             100                 105                 110        
 Ile Ile Ser Glu Glu Tyr Ile Lys Trp Leu Thr Gly Tyr Cys Lys Ala
         115                 120                 125            
 Tyr Phe Tyr Gly Leu Arg Val Lys Leu Leu Glu Pro Val Pro Val Ser
     130                 135                 140                
 Val Thr Arg Cys Ser Phe Arg Val Asn Glu Asn Thr His Asn Leu Gln
 145                 150                 155                 160
 Ile His Ala Gly Asp Ile Leu Lys Phe Leu Lys Lys Lys Lys Pro Glu
                 165                 170                 175    
 Asp Ala Phe Cys Val Val Gly Ile Thr Met Ile Asp Leu Tyr Pro Arg
             180                 185                 190        
 Asp Ser Trp Asn Phe Val Phe Gly Gln Ala Ser Leu Thr Asp Gly Val
         195                 200                 205            
 Gly Ile Phe Ser Phe Ala Arg Tyr Gly Ser Asp Phe Tyr Ser Met His
     210                 215                 220                
 Tyr Lys Gly Lys Val Lys Lys Leu Lys Lys Thr Ser Ser Ser Asp Tyr
 225                 230                 235                 240
 Ser Ile Phe Asp Asn Tyr Tyr Ile Pro Glu Ile Thr Ser Val Leu Leu
                 245                 250                 255    
 Leu Arg Ser Cys Lys Thr Leu Thr His Glu Ile Gly His Ile Phe Gly
             260                 265                 270        
 Leu Arg His Cys Gln Trp Leu Ala Cys Leu Met Gln Gly Ser Asn His
         275                 280                 285            
 Leu Glu Glu Ala Asp Arg Arg Pro Leu Asn Leu Cys Pro Ile Cys Leu
     290                 295                 300                
 His Lys Leu Gln Cys Ala Val Gly Phe Ser Ile Val Glu Arg Tyr Lys
 305                 310                 315                 320
 Ala Leu Val Arg Trp Ile Asp Asp Glu Ser Ser Asp Thr Pro Gly Ala
                 325                 330                 335    
 Thr Pro Glu His Ser His Glu Asp Asn Gly Asn Leu Pro Lys Pro Val
             340                 345                 350        
 Glu Ala Phe Lys Glu Trp Lys Glu Trp Ile Ile Lys Cys Leu Ala Val
         355                 360                 365            
 Leu Gln Lys
     370    



      <210> 1710
      <211> 511
      <212> PRT
      <213> Homo sapiens


      <400> 1710
 Leu Thr Leu Glu Asn Gln Ile Lys Glu Glu Arg Glu Gln Asp Asn Ser
   1               5                  10                  15    
 Glu Ser Pro Asn Gly Arg Thr Ser Pro Leu Val Ser Gln Asn Asn Glu
              20                  25                  30        
 Gln Gly Ser Thr Leu Arg Asp Leu Leu Thr Thr Thr Ala Gly Lys Leu
          35                  40                  45            
 Arg Val Gly Ser Thr Asp Ala Gly Ile Ala Phe Ala Pro Val Tyr Ser
      50                  55                  60                
 Met Gly Ala Pro Ser Ser Lys Ser Gly Arg Thr Met Pro Asn Ile Leu
  65                  70                  75                  80
 Asp Asp Ile Ile Ala Ser Val Val Glu Asn Lys Ile Pro Pro Ser Lys
                  85                  90                  95    
 Thr Ser Lys Ile Asn Val Lys Pro Glu Leu Lys Glu Glu Pro Glu Glu
             100                 105                 110        
 Ser Ile Ile Ser Ala Val Asp Glu Asn Asn Lys Leu Tyr Ser Asp Ile
         115                 120                 125            
 Pro His Ser Trp Ile Cys Glu Lys His Ile Leu Trp Leu Lys Asp Tyr
     130                 135                 140                
 Lys Asn Ser Ser Asn Trp Lys Leu Phe Lys Glu Cys Trp Lys Gln Gly
 145                 150                 155                 160
 Gln Pro Ala Val Val Ser Gly Val His Lys Lys Met Asn Ile Ser Leu
                 165                 170                 175    
 Trp Lys Ala Glu Ser Ile Ser Leu Asp Phe Gly Asp His Gln Ala Asp
             180                 185                 190        
 Leu Leu Asn Cys Lys Asp Ser Ile Ile Ser Asn Ala Asn Val Lys Glu
         195                 200                 205            
 Phe Trp Asp Gly Phe Glu Glu Val Ser Lys Arg Gln Lys Asn Lys Ser
     210                 215                 220                
 Gly Glu Thr Val Val Leu Lys Leu Lys Asp Trp Pro Ser Gly Glu Asp
 225                 230                 235                 240
 Phe Lys Thr Met Met Pro Ala Arg Tyr Glu Asp Leu Leu Lys Ser Leu
                 245                 250                 255    
 Pro Leu Pro Glu Tyr Cys Asn Pro Glu Gly Lys Phe Asn Leu Ala Ser
             260                 265                 270        
 His Leu Pro Gly Phe Phe Val Arg Pro Asp Leu Gly Pro Arg Leu Cys
         275                 280                 285            
 Ser Ala Tyr Gly Val Val Ala Ala Lys Asp His Asp Ile Gly Thr Thr
     290                 295                 300                
 Asn Leu His Ile Glu Val Ser Asp Val Val Asn Ile Leu Val Tyr Val
 305                 310                 315                 320
 Gly Ile Ala Lys Gly Asn Gly Ile Leu Ser Lys Ala Gly Ile Leu Lys
                 325                 330                 335    
 Lys Phe Glu Glu Glu Asp Leu Asp Asp Ile Leu Arg Lys Arg Leu Lys
             340                 345                 350        
 Asp Ser Ser Glu Ile Pro Gly Ala Leu Trp His Ile Tyr Ala Gly Lys
         355                 360                 365            
 Asp Val Asp Lys Ile Arg Glu Phe Leu Gln Lys Ile Ser Lys Glu Gln
     370                 375                 380                
 Gly Leu Glu Val Leu Pro Glu His Asp Pro Ile Arg Asp Gln Ser Trp
 385                 390                 395                 400
 Tyr Val Asn Lys Lys Leu Arg Gln Arg Leu Leu Glu Glu Tyr Gly Val
                 405                 410                 415    
 Arg Thr Trp Thr Leu Ile Gln Phe Leu Gly Asp Ala Ile Val Leu Pro
             420                 425                 430        
 Ala Gly Ala Leu His Gln Val Gln Asn Phe His Ser Cys Ile Gln Val
         435                 440                 445            
 Thr Glu Asp Phe Val Ser Pro Glu His Leu Val Glu Ser Phe His Leu
     450                 455                 460                
 Thr Gln Glu Leu Arg Leu Leu Lys Glu Glu Ile Asn Tyr Asp Asp Lys
 465                 470                 475                 480
 Leu Gln Val Lys Asn Ile Leu Tyr His Ala Val Lys Glu Met Val Arg
                 485                 490                 495    
 Ala Leu Lys Ile His Glu Asp Glu Val Asp Asp Met Glu Glu Asn
             500                 505                 510    



      <210> 1711
      <211> 236
      <212> PRT
      <213> Homo sapiens


      <400> 1711
 Ser Pro Leu Gly Lys Glu Gly Gln Glu Glu Val Arg Val Lys Ile Lys
   1               5                  10                  15    
 Asp Leu Asn Glu His Ile Val Cys Cys Leu Cys Ala Gly Tyr Phe Val
              20                  25                  30        
 Asp Ala Thr Thr Ile Thr Glu Cys Leu His Thr Phe Cys Lys Ser Cys
          35                  40                  45            
 Ile Val Lys Tyr Leu Gln Thr Ser Lys Tyr Cys Pro Met Cys Asn Ile
      50                  55                  60                
 Lys Ile His Glu Thr Gln Pro Leu Leu Asn Leu Lys Leu Asp Arg Val
  65                  70                  75                  80
 Met Gln Asp Ile Val Tyr Lys Leu Val Pro Gly Leu Gln Asp Ser Glu
                  85                  90                  95    
 Glu Lys Arg Ile Arg Glu Phe Tyr Gln Ser Arg Gly Leu Asp Arg Val
             100                 105                 110        
 Thr Gln Pro Thr Gly Glu Glu Pro Ala Leu Ser Asn Leu Gly Leu Pro
         115                 120                 125            
 Phe Ser Ser Phe Asp His Ser Lys Ala His Tyr Tyr Arg Tyr Asp Glu
     130                 135                 140                
 Gln Leu Asn Leu Cys Leu Glu Arg Leu Ser Ser Gly Lys Asp Lys Asn
 145                 150                 155                 160
 Lys Ser Val Leu Gln Asn Lys Tyr Val Arg Cys Ser Val Arg Ala Glu
                 165                 170                 175    
 Val Arg His Leu Arg Arg Val Leu Cys His Arg Leu Met Leu Asn Pro
             180                 185                 190        
 Gln His Val Gln Leu Leu Phe Asp Asn Glu Val Leu Pro Asp His Met
         195                 200                 205            
 Thr Met Lys Gln Ile Trp Leu Ser Arg Trp Phe Gly Lys Pro Ser Pro
     210                 215                 220                
 Leu Leu Leu Gln Tyr Ser Val Lys Glu Lys Arg Arg
 225                 230                 235    



      <210> 1712
      <211> 84
      <212> PRT
      <213> Homo sapiens


      <400> 1712
 Leu Leu Thr Asp Thr Cys Cys Pro Gly Gly Leu Lys Ala Ile Gln Lys
   1               5                  10                  15    
 Tyr Leu Phe Phe Gly Met Gly Leu Val Arg Thr Val Ile Leu Leu Gln
              20                  25                  30        
 Gly Asp Ile Gly Arg Trp Pro Asp Val Arg Ala Leu Leu Glu Lys Val
          35                  40                  45            
 Trp Ser Ala Pro Val Arg Asn Cys Ser Ala Leu Gln Gln His Gln Leu
      50                  55                  60                
 Ala Ala Thr Leu Ala Arg Leu Pro Arg Leu Lys Pro Leu Ala Val Arg
  65                  70                  75                  80
 Ala Gly Val Asp
                



      <210> 1713
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 1713
 Met Leu Ser Val Asn Leu Ser Trp Ser Thr His Leu Leu Arg Trp Ile
   1               5                  10                  15    
 Thr Phe Phe Tyr Leu Ser Ile Gly Thr Ala His Leu Tyr His Trp Leu
              20                  25                  30        
 Glu Met Arg Thr Lys Met Arg Ile Met Gly Phe Asn Ala Ala Ala Ile
          35                  40                  45            
 Lys Pro Leu Asn Glu Gly Ala Ala Ala Glu Leu Gly Ala Glu Leu Leu
      50                  55                  60                
 Gly Glu Gly Ile Ile Phe Ile Thr Ala Cys Ser Cys Leu Met Leu Glu
  65                  70                  75                  80
 Tyr Trp Arg His Gln Leu Gln Gln Arg Arg Lys Glu Lys Glu Arg Arg
                  85                  90                  95    
 Val Ala Arg Glu Ala Leu Arg Gly Glu Val Gly His Leu Gly Leu Ala
             100                 105                 110        





      <210> 1714
      <211> 274
      <212> PRT
      <213> Homo sapiens


      <400> 1714
 Gly Glu Glu Arg Lys Ser Ser Ser Trp Gly Arg Val Asp Ala Met Glu
   1               5                  10                  15    
 Leu Pro Asn Tyr Ser Arg Gln Leu Leu Gln Gln Leu Tyr Thr Leu Cys
              20                  25                  30        
 Lys Glu Gln Gln Phe Cys Asp Cys Thr Ile Ser Ile Gly Thr Ile Tyr
          35                  40                  45            
 Phe Arg Ala His Lys Leu Val Leu Ala Ala Ala Ser Leu Leu Phe Lys
      50                  55                  60                
 Thr Leu Leu Asp Asn Thr Asp Thr Ile Ser Ile Asp Ala Ser Val Val
  65                  70                  75                  80
 Ser Pro Glu Glu Phe Ala Leu Leu Leu Glu Met Met Tyr Thr Gly Lys
                  85                  90                  95    
 Leu Pro Val Gly Lys His Asn Phe Ser Lys Ile Ile Ser Leu Ala Asp
             100                 105                 110        
 Ser Leu Gln Met Phe Asp Val Ala Val Ser Cys Lys Asn Leu Leu Thr
         115                 120                 125            
 Ser Leu Val Asn Cys Ser Val Gln Gly Gln Val Val Arg Asp Val Ser
     130                 135                 140                
 Ala Pro Ser Ser Glu Thr Phe Arg Lys Glu Pro Glu Lys Pro Gln Val
 145                 150                 155                 160
 Glu Ile Leu Ser Ser Glu Gly Ala Gly Glu Pro His Ser Ser Pro Glu
                 165                 170                 175    
 Leu Ala Ala Thr Pro Gly Gly Pro Val Lys Ala Glu Thr Glu Glu Ala
             180                 185                 190        
 Ala His Ser Val Ser Gln Glu Met Ser Val Asn Ser Pro Thr Ala Gln
         195                 200                 205            
 Glu Ser Gln Arg Asn Ala Glu Thr Pro Ala Glu Thr Pro Thr Thr Ala
     210                 215                 220                
 Glu Ala Cys Ser Pro Ser Pro Ala Val Gln Thr Phe Ser Glu Ala Lys
 225                 230                 235                 240
 Lys Thr Ser Thr Glu Pro Glu Arg Leu Ala Leu Met Val Thr Glu Met
                 245                 250                 255    
 Ala Ala Ala Ala Leu Thr Ser Gly Ala Ile Gln Gln Lys Val Ala Lys
             260                 265                 270        
 Ala Met
        



      <210> 1715
      <211> 125
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(125)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1715
 Gln Gly Ile Ala Leu Leu Thr Arg Met Gly Glu Ser Val Lys His Val
   1               5                  10                  15    
 Thr Gly Gly Tyr Lys Leu Arg Thr Arg Pro Leu Glu Phe Ala Ala Ile
              20                  25                  30        
 Gly Asp Tyr Leu Asp Thr Phe Ala Leu Lys Leu Gly Thr Ile Asp Arg
          35                  40                  45            
 Ile Ala Gln Arg Ile Ile Lys Glu Glu Ile Glu Tyr Leu Val Glu Leu
      50                  55                  60                
 Arg Glu Tyr Gly Pro Val Tyr Ser Thr Trp Ser Ala Leu Glu Gly Glu
  65                  70                  75                  80
 Leu Ala Glu Pro Leu Glu Gly Val Ser Ala Cys Ile Gly Asn Cys Ser
                  85                  90                  95    
 Thr Ala Leu Xaa Glu Leu Thr Asp Asp Met Thr Glu Asp Phe Leu Phe
             100                 105                 110        
 Val Leu Arg Glu Tyr Ile Leu Tyr Ser Asp Ser Met Lys
         115                 120                 125



      <210> 1716
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 1716
 His Leu Ala His Ser Leu Gly Pro Leu Pro Lys His Tyr Gln Tyr Cys
   1               5                  10                  15    
 Val Arg Tyr Leu Tyr Tyr Gln Val Thr Lys Asp Val Ile Lys Glu Phe
              20                  25                  30        
 Ala Asp Asp Gly Val Lys Tyr Leu Glu Leu Arg Ser Thr Pro Arg Arg
          35                  40                  45            
 Glu Asn Ala Thr Gly Met Thr Lys Lys Thr Tyr Val Glu Ser Ile Leu
      50                  55                  60                
 Glu Gly Ile Lys Gln Ser Lys Gln Glu Asn Leu Asp Ile Asp Val
  65                  70                  75                



      <210> 1717
      <211> 229
      <212> PRT
      <213> Homo sapiens


      <400> 1717
 Ser Ala Gly Phe Ser Arg Pro Leu Ala Ala Pro Gly Val Met Tyr Gly
   1               5                  10                  15    
 Ser Gln Lys Gly Thr Thr Phe Thr Lys Ile Phe Val Gly Gly Leu Pro
              20                  25                  30        
 Tyr His Thr Thr Asp Ala Ser Leu Arg Lys Tyr Phe Glu Gly Phe Gly
          35                  40                  45            
 Asp Ile Glu Glu Ala Val Val Ile Thr Asp Arg Gln Thr Gly Lys Ser
      50                  55                  60                
 Arg Gly Tyr Gly Phe Val Thr Met Ala Asp Arg Ala Ala Ala Glu Arg
  65                  70                  75                  80
 Ala Cys Lys Asp Pro Asn Pro Ile Ile Asp Gly Arg Lys Ala Asn Val
                  85                  90                  95    
 Asn Leu Ala Tyr Leu Gly Ala Lys Pro Arg Ser Leu Gln Thr Gly Phe
             100                 105                 110        
 Ala Ile Gly Val Gln Gln Leu His Pro Thr Leu Ile Gln Arg Thr Tyr
         115                 120                 125            
 Gly Leu Thr Pro His Tyr Ile Tyr Pro Pro Ala Ile Val Gln Pro Ser
     130                 135                 140                
 Val Val Ile Pro Ala Ala Pro Val Pro Ser Leu Ser Ser Pro Tyr Ile
 145                 150                 155                 160
 Glu Tyr Thr Pro Ala Ser Pro Ala Tyr Ala Gln Tyr Pro Pro Ala Thr
                 165                 170                 175    
 Tyr Asp Gln Tyr Pro Tyr Ala Ala Ser Pro Ala Thr Ala Ala Ser Phe
             180                 185                 190        
 Val Gly Tyr Ser Tyr Pro Ala Ala Val Pro Gln Ala Leu Ser Ala Ala
         195                 200                 205            
 Ala Pro Ala Gly Thr Thr Phe Val Gln Tyr Gln Ala Pro Gln Leu Gln
     210                 215                 220                
 Pro Asp Arg Met Gln
 225                



      <210> 1718
      <211> 397
      <212> PRT
      <213> Homo sapiens


      <400> 1718
 Pro Leu Leu Lys Val Ala Glu Ile Leu Lys Glu Lys Glu Phe Cys Pro
   1               5                  10                  15    
 Gly Glu Arg Asn Ser Tyr Glu Pro Ile Lys Glu Phe Gln Lys Glu Ala
              20                  25                  30        
 Glu Lys Phe Leu Pro Leu Phe Gly His Ile Gly Gly Thr Gln Ser Lys
          35                  40                  45            
 Gly Pro Trp Glu Glu Leu Ala Lys Gly Ser Pro His Ser Val Ile Asn
      50                  55                  60                
 Ile Phe Thr Lys Ser Tyr Gln Leu Tyr Gly Lys Gly Phe Glu Asp Lys
  65                  70                  75                  80
 Leu Asp Arg Gly Thr Ser Thr Ser Arg Pro Leu Asn Ala Thr Ala Thr
                  85                  90                  95    
 Pro Leu Ser Gly Val Ser Tyr Glu Asp Asp Phe Val Ser Ser Pro Gly
             100                 105                 110        
 Thr Gly Thr Ser Thr Glu Lys Lys Ser Thr Leu Glu Pro His Ser Thr
         115                 120                 125            
 Leu Ser Pro Gln Glu Asp His Ser Asn Arg Lys Ser Ala Tyr Asp Pro
     130                 135                 140                
 Ser Ser Val Asp Val Thr Ser Gln His Ser Ser Gly Ala Gln Ser Ala
 145                 150                 155                 160
 Ala Ser Ser Arg Ser Ser Thr Ser Ser Lys Gly Lys Lys Gly Lys Lys
                 165                 170                 175    
 Glu Lys Thr Glu Trp Leu Asp Ser Phe Thr Gly Asn Val Gln Asn Ser
             180                 185                 190        
 Leu Leu Asp Glu Glu Lys Ala Glu Arg Gly Ser His Gln Gly Lys Lys
         195                 200                 205            
 Ser Gly Thr Ser Ser Lys Leu Ser Val Lys Asp Phe Glu Gln Thr Leu
     210                 215                 220                
 Asp Thr Asp Ser Thr Leu Glu Asp Leu Ser Gly His Ser Val Ser Val
 225                 230                 235                 240
 Ser Ser Asp Lys Gly Arg Ser Gln Lys Thr Pro Thr Ser Pro Leu Ser
                 245                 250                 255    
 Pro Ser Ser Gln Lys Ser Leu Gln Phe Asp Val Ala Gly Thr Ser Ser
             260                 265                 270        
 Glu Arg Ser Lys Ser Ser Val Met Pro Pro Thr Ile Thr Gly Phe Lys
         275                 280                 285            
 Pro Asn Ala Pro Leu Thr Asp Leu Asn Pro Ala Ala Ser Arg Thr Thr
     290                 295                 300                
 Thr Glu Asn Met Ala Pro Ile Pro Gly Ser Lys Arg Phe Ser Pro Ala
 305                 310                 315                 320
 Gly Leu His His Arg Met Ala Ala Glu Leu Ser Tyr Leu Asn Ala Ile
                 325                 330                 335    
 Glu Glu Ser Val Arg Gln Leu Ser Asp Val Glu Arg Val Arg Gly Ile
             340                 345                 350        
 Ser Leu Ala Gln Gln Glu Ser Val Ser Leu Ala Gln Ile Ile Lys Ala
         355                 360                 365            
 Gln Gln Gln Arg His Glu Arg Asp Leu Ala Leu Leu Lys Leu Lys Ala
     370                 375                 380                
 Glu Gln Glu Ala Leu Glu Ser Gln Arg Gln Lys Lys Lys
 385                 390                 395        



      <210> 1719
      <211> 1373
      <212> PRT
      <213> Homo sapiens


      <400> 1719
 Asn Lys Thr Gly Met Ser Thr Ile Ala Lys Cys Asp Gly Glu Arg Asp
   1               5                  10                  15    
 Asp Thr Thr Gln Asn Ile Thr Glu Val Ala Ala Val Lys Ser Ile Ser
              20                  25                  30        
 Pro Glu Val Ser Ala Ser Arg Arg Lys Leu Asp Phe Asn Ser Pro Gly
          35                  40                  45            
 Gly Ser Ser Pro Val Glu Asn Ser Asp Cys Ser Thr Asn Ser Arg Leu
      50                  55                  60                
 Ser Phe Ser Pro Glu Asn Ile Leu Ile Gln Asn Gln Asp Ile Val Arg
  65                  70                  75                  80
 Glu Ala Ala Val Gln Gly Asp Gly Gln Lys Gln Arg Gln Pro Gln Ala
                  85                  90                  95    
 Thr Asp Leu Asp Ser Ser Gly Thr His Gly Ser Glu Met Leu Pro Ala
             100                 105                 110        
 Thr Glu Val Thr Val Ser Gly Gly Phe Ser Val Glu Glu Thr Ser Cys
         115                 120                 125            
 Gly Asp Thr Gly Arg Ser Gly Gly Glu Ala Leu Ala Val Ala Asn Asp
     130                 135                 140                
 Ser Thr Ser Thr Pro Gln Asn Ala Asn Gly Leu Trp Lys Leu Lys Ser
 145                 150                 155                 160
 Thr Thr Pro Gly Gly Ala Leu Pro Glu Cys Phe Gly Thr Thr Asp Thr
                 165                 170                 175    
 Thr Phe Ser Ser Ala Phe Cys Arg Lys His Gly Glu Thr Gln Asp Thr
             180                 185                 190        
 Ser Gln Ser Ser Leu Pro Gly Thr Leu His Cys Tyr Thr Gly Ile Arg
         195                 200                 205            
 Glu Gly Gly Asp Asp Thr Glu Val Glu Ser Glu Ala Phe Ser Cys Ser
     210                 215                 220                
 Glu Gly Ser Glu Gln Gln Asp Ala Pro Asp Asp Ser Gln Lys Asn Leu
 225                 230                 235                 240
 Gly Asp Thr Asp Ala Ala Val Ala Glu Val Arg Pro Ser Leu Glu Val
                 245                 250                 255    
 Gly Tyr Leu Thr Ser Ala Leu Gln Asp Phe Asn Ile Ser Thr Phe Ser
             260                 265                 270        
 Glu Leu Asp Arg Leu Ser Thr Ser Glu Val Val Met Phe Leu Glu Ser
         275                 280                 285            
 Cys Gln Leu Gly Asp Tyr Ser Ser Gly Asp Ser Val Ser Glu Cys Ser
     290                 295                 300                
 Ser Lys Gly Thr Leu Ser Lys Glu Met Asn Lys Glu Leu Lys Ala Ser
 305                 310                 315                 320
 Glu Ile Gly Glu Lys Tyr Arg Lys Gln Pro Cys Glu Glu Glu Thr Leu
                 325                 330                 335    
 Gly Thr Cys Glu Glu Trp Ile Glu Ser Glu Glu Asp Asp Tyr Ser Leu
             340                 345                 350        
 Lys Asn Thr Ser Gln Leu Thr Gln Cys Ser Leu Glu Thr Leu Ser Glu
         355                 360                 365            
 Val Leu Thr Lys Ile Arg Gln Glu Leu Gln Thr Asn Ser Glu Asp Cys
     370                 375                 380                
 Asn Gly Lys Asp Thr Gly Ser Leu Leu Leu Leu Asn Val Asn Asn Asn
 385                 390                 395                 400
 Met Thr Thr Glu Asn Leu Lys Glu Lys Ser Pro Phe Arg Glu Thr Thr
                 405                 410                 415    
 Gly Ser Ser Ser His Ala Ser Glu Pro Thr Pro Gln Ala Ala Ala Leu
             420                 425                 430        
 Asp Thr Glu Gly Ser Ser Pro Ile Ser Gly Met Pro Gln Asn Glu Asn
         435                 440                 445            
 Pro Gln Ser Arg Pro Glu Ala Arg Ser Asp Ala Gly Arg Gln Thr Asp
     450                 455                 460                
 Gly Gly Glu Glu Asp Leu Pro Glu Pro Val Glu Pro Ser Ala Leu Cys
 465                 470                 475                 480
 Ser Asp Ser Val Met Glu Pro Ser Ile Glu Gln Ser Ser Asn Cys Glu
                 485                 490                 495    
 Ala Glu Thr Thr Phe Gln Cys Gln Ile Ala Thr Val Thr Ser Glu Val
             500                 505                 510        
 Ile Asn Val Leu Ile Asn Lys Asp Gln Asn Leu Val Ile Glu Lys Gly
         515                 520                 525            
 Asp Asn Trp Thr Ile Ile Ser Gly Val Ala Val Leu Pro His Val Asp
     530                 535                 540                
 Gln Val Thr Leu Cys Asp Ile Pro Gly Asp Ile Pro Ile Ser Gln Asp
 545                 550                 555                 560
 Gln Gly Glu Leu Glu Ala Gly Cys Ile Pro Val Thr Ser Ala Glu Lys
                 565                 570                 575    
 Ser Pro Glu Ala Ser His Thr Gly Pro Ala Phe Gln Glu Ala Pro Cys
             580                 585                 590        
 Gly Asn Asn Leu Ser Cys Pro Gln Glu Asp Val Ser Ser Ser Gly Gln
         595                 600                 605            
 Ser Thr Asn Phe Asp Lys Ser Arg Leu Arg Asn Arg Pro Val Lys Pro
     610                 615                 620                
 Ser Ile Trp Ile Ser Ser Gln Ile Tyr Asp Gln Asn Phe Glu Thr Gln
 625                 630                 635                 640
 Ile Val Ala Ser Asp His Thr Tyr Tyr Asn Ser Lys Leu Glu Pro Ser
                 645                 650                 655    
 Gly Lys Asn Lys Asn Arg Ser Lys Ile Ser Asn Lys Asp Gln Ser Asn
             660                 665                 670        
 Lys Pro Val Lys Thr Ser Ala Ser Ser Arg Val Glu Thr His Gln Ser
         675                 680                 685            
 Glu Val Ala Gln Ser Phe Ser Gly Glu Lys Ala Asn Thr Lys Thr Gln
     690                 695                 700                
 Arg Ser Gln Thr Gln Thr Ile Leu Ala Asn Ala Asp Thr Ser Thr Pro
 705                 710                 715                 720
 Thr Asp Cys Ser Pro Asp Thr Leu Ser Lys Ile Arg Gln Glu Val Gly
                 725                 730                 735    
 Pro Pro Leu Pro Pro Leu Leu Ala Pro Leu Ile Ala Thr Pro Pro Arg
             740                 745                 750        
 Thr Ser Gln Pro Leu Ser Pro Leu Ile Ser Ser Ser Ser Pro Ser Ser
         755                 760                 765            
 Pro Ala Ser Pro Val Gly Gln Val Ser Pro Phe Arg Glu Thr Pro Val
     770                 775                 780                
 Pro Pro Ala Met Ser Pro Trp Pro Glu Asp Pro Arg Arg Ala Ser Pro
 785                 790                 795                 800
 Pro Asp Pro Ser Pro Ser Pro Ser Ala Ala Ser Ala Ser Glu Arg Val
                 805                 810                 815    
 Val Pro Ser Pro Leu Gln Phe Cys Ala Ala Thr Pro Lys His Ala Leu
             820                 825                 830        
 Pro Val Pro Gly Arg Leu Pro Pro Cys Ala Ser Gly His Ala Ala Val
         835                 840                 845            
 Gly Gly Pro Gln Glu Asn Ser Val Lys Ile Leu Asp Thr Met Tyr Pro
     850                 855                 860                
 Glu Leu Ser Ala Arg Ala Arg Thr Leu Asn Ile Leu Lys Gly Asn Ile
 865                 870                 875                 880
 Gln Leu Thr Arg Gly Pro Pro Ala Asp Cys Lys Asn Leu Pro Gly Pro
                 885                 890                 895    
 Ala Ser Ala Met Ile Gly Phe Lys Thr Ile Thr Ser Ala Ala Thr Ala
             900                 905                 910        
 Phe Val Lys Thr Gly Ser Ser Ser Gly Gly Asp Cys Asn Gln Asp Lys
         915                 920                 925            
 Ser Arg Asp Leu Gly Thr Gln Gln Asp Ser Ser Gly Lys Arg Thr Leu
     930                 935                 940                
 Ser Thr Ser Thr Leu Arg Ser Ala Lys Arg Leu Arg Leu Asp Thr Gly
 945                 950                 955                 960
 Ser Pro Glu Pro Glu Thr Arg Gly Val Thr Ala Glu Gly Ile His Lys
                 965                 970                 975    
 Asn Leu Pro Gly Asn Leu Pro Pro Ala Glu Val Ala Thr Thr Asn Glu
             980                 985                 990        
 Glu Arg Ser Cys Ser Ser Pro Ala Val Ser Ala Val Ser Gln Leu Pro
         995                1000                1005            
 Leu Ser Pro Lys Glu Thr Val Glu Ser His Asp Lys Ala Ile Ala Asn
    1010                1015                1020                
 Ala Leu Lys Lys Ile Ala Glu Phe Ser Phe Asp Leu Leu Pro Val Ile
1025                1030                1035                1040
 Arg Ser His Val Tyr Val Gly Asn Ile Ser Lys Lys Pro Val Met Arg
                1045                1050                1055    
 Asp Gln Glu Lys Glu Val Val Tyr Glu Phe Ser Thr Thr Lys Lys His
            1060                1065                1070        
 Leu Ala Glu Cys Leu Leu His Ser Ile Leu Ser Glu Leu Lys Ile Gln
        1075                1080                1085            
 Lys Ile Ser Met Asp His Asn Tyr Ile His Ala Leu Cys Arg Val Tyr
    1090                1095                1100                
 Val Gly Ile Cys Arg Gln Leu Gly Asp Leu Glu Arg Ala Arg Leu Phe
1105                1110                1115                1120
 Cys Tyr Ser Leu Leu Lys Glu Asp Phe Pro Glu Ser Glu Lys Leu Thr
                1125                1130                1135    
 Leu Phe Ile Ala Asn Met Trp His Asp Ile Phe Leu Ser Gln Ser Val
            1140                1145                1150        
 Ile Asn Lys Ala Met Gln Leu Val Ala Arg Gln Arg Ala Lys Gly Glu
        1155                1160                1165            
 Val Leu Asn Cys Leu Arg Ala Phe Leu Asn Trp Glu Lys Asn Ala Pro
    1170                1175                1180                
 Val Asp Val Gly Phe Met Val Ser Lys Leu Leu Leu Thr Ile Gln Leu
1185                1190                1195                1200
 Cys Pro Lys Thr Glu Phe Gln Pro Ser Glu Lys Phe Gly Glu Asp Leu
                1205                1210                1215    
 Ser Asp Asn Thr Trp Glu Tyr Ile Phe Ala Ile Asp Leu Leu Cys Cys
            1220                1225                1230        
 His Gln Lys Trp Ile Trp Thr His Asp Asn Ile Ile Ser Lys Glu Leu
        1235                1240                1245            
 Trp Pro Val Met Asp Lys Trp Ile Lys Tyr Arg Lys Gly His Ala Asn
    1250                1255                1260                
 Ile Ala Tyr Thr Pro Asp Ile Ile Ile Ala Ser Ile Leu Arg Leu Ile
1265                1270                1275                1280
 Gly Arg Leu Gly Gln Leu Gly Leu Lys Glu Gly Phe Pro Ser Ala Val
                1285                1290                1295    
 Lys Asn Ile Ser Ser Val Ile Gly Met Phe Ile Gln His Ala His Asp
            1300                1305                1310        
 Glu Asp Ile Pro Trp Gly Ile Gln Leu Ala Ala Val Tyr Ala Leu Cys
        1315                1320                1325            
 Asp Leu Ser Pro Ser Asn Pro Ala Glu Ile Ser Lys Ile Leu Glu Ala
    1330                1335                1340                
 Trp Arg Arg Glu Ala Ser Lys Ser Val Pro Ser Ala Ile Val Ser Cys
1345                1350                1355                1360
 Leu Glu Glu Val Ser Ala Leu Ser Thr Glu Glu Leu Gly
                1365                1370            



      <210> 1720
      <211> 161
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(161)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1720
 Pro Gly Arg Ile Met Gly Leu Pro Arg Gly Pro Glu Gly Gln Gly Leu
   1               5                  10                  15    
 Pro Glu Val Glu Thr Arg Glu Asp Glu Glu Gln Asn Val Lys Leu Thr
              20                  25                  30        
 Glu Ile Leu Glu Leu Leu Val Ala Ala Gly Tyr Phe Arg Ala Arg Ile
          35                  40                  45            
 Lys Gly Leu Ser Pro Phe Asp Lys Val Val Gly Gly Met Thr Trp Cys
      50                  55                  60                
 Ile Thr Thr Cys Asn Phe Asp Val Asp Val Asp Leu Leu Phe Gln Glu
  65                  70                  75                  80
 Asn Ser Thr Ile Gly Gln Lys Ile Ala Leu Ser Glu Lys Ile Val Ser
                  85                  90                  95    
 Val Leu Pro Arg Met Lys Cys Pro His Gln Leu Glu Pro His Gln Ile
             100                 105                 110        
 Gln Gly Met Asp Phe Ile His Ile Phe Pro Val Val Gln Trp Leu Val
         115                 120                 125            
 Lys Arg Ala Ile Gln Thr Lys Glu Glu Met Gly Asp Tyr Ile Arg Ser
     130                 135                 140                
 Tyr Ser Val Ser Gln Xaa Gln Lys Thr Tyr Ser Leu Pro Glu Asp Asp
 145                 150                 155                 160
 Asp
    



      <210> 1721
      <211> 514
      <212> PRT
      <213> Homo sapiens


      <400> 1721
 Ala Trp Ala Pro Gly Glu Ala Ala Ala Ala Ala Ala Ala Gly Ala Ala
   1               5                  10                  15    
 Arg Ala Ala Arg Ala Pro Gln Pro Gly Pro Val Leu Gly Ala Met Ser
              20                  25                  30        
 Gly Gly Gly Pro Ser Gly Gly Gly Pro Gly Gly Ser Gly Arg Ala Arg
          35                  40                  45            
 Thr Ser Ser Phe Ala Glu Pro Gly Gly Gly Gly Gly Gly Gly Gly Gly
      50                  55                  60                
 Gly Pro Gly Gly Ser Ala Ser Gly Pro Gly Gly Thr Gly Gly Gly Lys
  65                  70                  75                  80
 Ala Ser Val Gly Ala Met Gly Gly Gly Val Gly Ala Ser Ser Ser Gly
                  85                  90                  95    
 Gly Gly Pro Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Pro Gly Ala
             100                 105                 110        
 Gly Thr Ser Phe Pro Pro Pro Gly Val Lys Leu Gly Arg Asp Ser Gly
         115                 120                 125            
 Lys Val Thr Thr Val Val Ala Thr Leu Gly Gln Gly Pro Glu Arg Ser
     130                 135                 140                
 Gln Glu Val Ala Tyr Thr Asp Ile Lys Val Ile Gly Asn Gly Ser Phe
 145                 150                 155                 160
 Gly Val Val Tyr Gln Ala Arg Leu Ala Glu Thr Arg Glu Leu Val Ala
                 165                 170                 175    
 Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg Glu Leu Gln
             180                 185                 190        
 Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu Arg Tyr Phe
         195                 200                 205            
 Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Leu Tyr Leu Asn Leu Val
     210                 215                 220                
 Leu Glu Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg His Phe Thr
 225                 230                 235                 240
 Lys Ala Lys Leu Thr Ile Pro Ile Leu Tyr Val Lys Val Tyr Met Tyr
                 245                 250                 255    
 Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Gln Gly Val Cys His
             260                 265                 270        
 Arg Asp Ile Lys Pro Gln Asn Leu Leu Val Asp Pro Asp Thr Ala Val
         275                 280                 285            
 Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val Arg Gly Glu
     290                 295                 300                
 Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala Pro Glu Leu
 305                 310                 315                 320
 Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val Trp Ser Ala
                 325                 330                 335    
 Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile Phe Pro Gly
             340                 345                 350        
 Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val Leu Gly Thr
         355                 360                 365            
 Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr Thr Glu Phe
     370                 375                 380                
 Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val Phe Lys Ser
 385                 390                 395                 400
 Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Ser Leu Leu Glu Tyr
                 405                 410                 415    
 Thr Pro Ser Ser Arg Leu Ser Pro Leu Glu Ala Cys Ala His Ser Phe
             420                 425                 430        
 Phe Asp Glu Leu Arg Cys Leu Gly Thr Gln Leu Pro Asn Asn Arg Pro
         435                 440                 445            
 Leu Pro Pro Leu Phe Asn Phe Ser Ala Gly Glu Leu Ser Ile Gln Pro
     450                 455                 460                
 Ser Leu Asn Ala Ile Leu Ile Pro Pro Ser Leu Gly Gly Ser Pro Ala
 465                 470                 475                 480
 Gly Thr Thr Thr Leu Thr Pro Ser Ser Gln Ala Leu Thr Glu Thr Pro
                 485                 490                 495    
 Thr Ser Ser Asp Trp Gln Ser Thr Asp Ala Thr Pro Thr Leu Thr Asn
             500                 505                 510        
 Ser Ser
        



      <210> 1722
      <211> 514
      <212> PRT
      <213> Homo sapiens


      <400> 1722
 Ala Trp Ala Pro Gly Glu Ala Ala Ala Ala Ala Ala Ala Gly Ala Ala
   1               5                  10                  15    
 Arg Ala Ala Arg Ala Pro Gln Pro Gly Pro Val Leu Gly Ala Met Ser
              20                  25                  30        
 Gly Gly Gly Pro Ser Gly Gly Gly Pro Gly Gly Ser Gly Arg Ala Arg
          35                  40                  45            
 Thr Ser Ser Phe Ala Glu Pro Gly Gly Gly Gly Gly Gly Gly Gly Gly
      50                  55                  60                
 Gly Pro Gly Gly Ser Ala Ser Gly Pro Gly Gly Thr Gly Gly Gly Lys
  65                  70                  75                  80
 Ala Ser Val Gly Ala Met Gly Gly Gly Val Gly Ala Ser Ser Ser Gly
                  85                  90                  95    
 Gly Gly Pro Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Pro Gly Ala
             100                 105                 110        
 Gly Thr Ser Phe Pro Pro Pro Gly Val Lys Leu Gly Arg Asp Ser Gly
         115                 120                 125            
 Lys Val Thr Thr Val Val Ala Thr Leu Gly Gln Gly Pro Glu Arg Ser
     130                 135                 140                
 Gln Glu Val Ala Tyr Thr Asp Ile Lys Val Ile Gly Asn Gly Ser Phe
 145                 150                 155                 160
 Gly Val Val Tyr Gln Ala Arg Leu Ala Glu Thr Arg Glu Leu Val Ala
                 165                 170                 175    
 Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg Glu Leu Gln
             180                 185                 190        
 Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu Arg Tyr Phe
         195                 200                 205            
 Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Leu Tyr Leu Asn Leu Val
     210                 215                 220                
 Leu Glu Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg His Phe Thr
 225                 230                 235                 240
 Lys Ala Lys Leu Thr Ile Pro Ile Leu Tyr Val Lys Val Tyr Met Tyr
                 245                 250                 255    
 Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Gln Gly Val Cys His
             260                 265                 270        
 Arg Asp Ile Lys Pro Gln Asn Leu Leu Val Asp Pro Asp Thr Ala Val
         275                 280                 285            
 Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val Arg Gly Glu
     290                 295                 300                
 Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala Pro Glu Leu
 305                 310                 315                 320
 Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val Trp Ser Ala
                 325                 330                 335    
 Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile Phe Pro Gly
             340                 345                 350        
 Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val Leu Gly Thr
         355                 360                 365            
 Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr Thr Glu Phe
     370                 375                 380                
 Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val Phe Lys Ser
 385                 390                 395                 400
 Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Ser Leu Leu Glu Tyr
                 405                 410                 415    
 Thr Pro Ser Ser Arg Leu Ser Pro Leu Glu Ala Cys Ala His Ser Phe
             420                 425                 430        
 Phe Asp Glu Leu Arg Cys Leu Gly Thr Gln Leu Pro Asn Asn Arg Pro
         435                 440                 445            
 Leu Pro Pro Leu Phe Asn Phe Ser Ala Gly Glu Leu Ser Ile Gln Pro
     450                 455                 460                
 Ser Leu Asn Ala Ile Leu Ile Pro Pro Ser Leu Gly Gly Ser Pro Ala
 465                 470                 475                 480
 Gly Thr Thr Thr Leu Thr Pro Ser Ser Gln Ala Leu Thr Glu Thr Pro
                 485                 490                 495    
 Thr Ser Ser Asp Trp Gln Ser Thr Asp Ala Thr Pro Thr Leu Thr Asn
             500                 505                 510        
 Ser Ser
        



      <210> 1723
      <211> 111
      <212> PRT
      <213> Homo sapiens


      <400> 1723
 His Cys Glu Gly Gln Thr Pro Ala Pro Ala Pro Pro Pro Val Pro Leu
   1               5                  10                  15    
 Arg Leu Gly Pro Phe Ser Asp Ser Ile Ser Gly Arg Ala Ala Arg Pro
              20                  25                  30        
 Ala Pro Ser Trp Ala Gly Val Ser Gln Leu Glu Leu Val Ser Arg Leu
          35                  40                  45            
 Leu His Leu His Phe Lys Asp Asp Lys Thr Lys Val Ser Gly Asp Ala
      50                  55                  60                
 Leu Gln Leu Met Val Glu Leu Leu Lys Val Phe Val Val Glu Ala Ala
  65                  70                  75                  80
 Val Arg Gly Val Arg Gln Ala Gln Ala Glu Asp Ala Leu Arg Val Asp
                  85                  90                  95    
 Val Asp Gln Leu Glu Lys Val Leu Pro Gln Leu Leu Leu Asp Phe
             100                 105                 110    



      <210> 1724
      <211> 298
      <212> PRT
      <213> Homo sapiens


      <400> 1724
 Ile Pro Cys Ile Lys Arg Phe Pro Arg Gly Pro Pro Ala Thr Met Tyr
   1               5                  10                  15    
 Ile Ile Gly Gly Tyr Tyr Trp His Pro Leu Ser Glu Val His Ile Trp
              20                  25                  30        
 Asp Pro Leu Thr Asn Val Trp Ile Gln Gly Ala Glu Ile Pro Asp Tyr
          35                  40                  45            
 Thr Arg Glu Ser Tyr Gly Val Thr Cys Leu Gly Pro Asn Ile Tyr Val
      50                  55                  60                
 Thr Gly Gly Tyr Arg Thr Asp Asn Ile Glu Ala Leu Asp Thr Val Trp
  65                  70                  75                  80
 Ile Tyr Asn Ser Glu Ser Asp Glu Trp Thr Glu Gly Leu Pro Met Leu
                  85                  90                  95    
 Asn Ala Arg Tyr Tyr His Cys Ala Val Thr Leu Gly Gly Cys Val Tyr
             100                 105                 110        
 Ala Leu Gly Gly Tyr Arg Lys Gly Ala Pro Ala Glu Glu Ala Glu Phe
         115                 120                 125            
 Tyr Asp Pro Leu Lys Glu Lys Trp Ile Pro Ile Ala Asn Met Ile Lys
     130                 135                 140                
 Gly Val Gly Asn Ala Thr Ala Cys Val Leu His Asp Val Ile Tyr Val
 145                 150                 155                 160
 Ile Gly Gly His Cys Gly Tyr Arg Gly Ser Cys Thr Tyr Asp Lys Val
                 165                 170                 175    
 Gln Ser Tyr Asn Ser Asp Ile Ile Glu Trp Ser Leu Ile Thr Phe Ser
             180                 185                 190        
 Pro His Pro Glu Tyr Gly Leu Cys Ser Val Pro Phe Glu Asn Lys Leu
         195                 200                 205            
 Tyr Leu Val Gly Gly Gln Thr Thr Ile Thr Glu Cys Tyr Asp Pro Glu
     210                 215                 220                
 Gln Asn Glu Trp Arg Glu Ile Ala Pro Met Met Glu Arg Arg Met Glu
 225                 230                 235                 240
 Cys Gly Ala Val Ile Met Asn Gly Cys Ile Tyr Val Thr Gly Gly Tyr
                 245                 250                 255    
 Ser Tyr Ser Lys Gly Thr Tyr Leu Gln Ser Ile Glu Lys Tyr Asp Pro
             260                 265                 270        
 Asp Leu Asn Lys Trp Glu Ile Val Gly Asn Leu Pro Ser Ala Met Arg
         275                 280                 285            
 Ser His Gly Cys Val Cys Val Tyr Asn Val
     290                 295            



      <210> 1725
      <211> 73
      <212> PRT
      <213> Homo sapiens


      <400> 1725
 Met Ala Ser Thr Ala Asp Tyr Ser Arg Ser Ala Ala Ser Thr Arg Lys
   1               5                  10                  15    
 Cys Asp Cys Cys Asp Gly Gly Gly Phe Thr Glu Ala Gln Val Phe Thr
              20                  25                  30        
 Asn Lys Val Ser Tyr Pro Trp Gly Lys Pro Pro Tyr Trp Ser Lys Met
          35                  40                  45            
 Ser Arg Ala Val Arg Pro Ser Asp Trp Glu Ser Trp Thr Gln Ala His
      50                  55                  60                
 Arg Ile Ala Ser His Tyr Gly Val Leu
  65                  70            



      <210> 1726
      <211> 275
      <212> PRT
      <213> Homo sapiens


      <400> 1726
 Gly Arg Val Gly Gly Arg Val Gly Arg Thr Leu Pro Phe Met Val His
   1               5                  10                  15    
 Arg Val Ser Gly Gln Pro Gln Ser Val Thr Ala Ser Ser Asp Lys Ala
              20                  25                  30        
 Phe Glu Asp Trp Leu Asn Asp Asp Leu Gly Ser Tyr Gln Gly Ala Gln
          35                  40                  45            
 Gly Asn Arg Tyr Val Gly Phe Gly Asn Thr Pro Pro Pro Gln Lys Lys
      50                  55                  60                
 Glu Asp Asp Phe Leu Asn Asn Ala Met Ser Ser Leu Tyr Ser Gly Trp
  65                  70                  75                  80
 Ser Ser Phe Thr Thr Gly Ala Ser Arg Phe Ala Ser Ala Ala Lys Glu
                  85                  90                  95    
 Gly Ala Thr Lys Phe Gly Ser Gln Ala Ser Gln Lys Ala Ser Glu Leu
             100                 105                 110        
 Gly His Ser Leu Asn Glu Asn Val Leu Lys Pro Ala Gln Glu Lys Val
         115                 120                 125            
 Lys Glu Gly Lys Ile Phe Asp Asp Val Ser Ser Gly Val Ser Gln Leu
     130                 135                 140                
 Ala Ser Lys Val Gln Gly Val Gly Ser Lys Gly Trp Arg Asp Val Thr
 145                 150                 155                 160
 Thr Phe Phe Ser Gly Lys Ala Glu Gly Pro Leu Asp Ser Pro Ser Glu
                 165                 170                 175    
 Gly His Ser Tyr Gln Asn Ser Gly Leu Asp His Phe Gln Asn Ser Asn
             180                 185                 190        
 Ile Asp Gln Ser Phe Trp Glu Thr Phe Gly Ser Ala Glu Pro Thr Lys
         195                 200                 205            
 Thr Arg Lys Ser Pro Ser Ser Asp Ser Trp Thr Cys Ala Asp Thr Ser
     210                 215                 220                
 Thr Glu Arg Arg Ser Ser Asp Ser Trp Glu Val Trp Gly Ser Ala Ser
 225                 230                 235                 240
 Thr Asn Arg Asn Ser Asn Ser Asp Gly Gly Glu Gly Gly Glu Gly Thr
                 245                 250                 255    
 Lys Lys Ala Val Pro Pro Ala Val Pro Thr Asp Asp Gly Trp Asp Asn
             260                 265                 270        
 Gln Asn Trp
         275



      <210> 1727
      <211> 105
      <212> PRT
      <213> Homo sapiens


      <400> 1727
 His Leu Leu Gly Ala Trp Arg Gly His Pro Ser His Pro Gln Pro Ser
   1               5                  10                  15    
 Pro Ala Gly Ala Pro Tyr Pro Trp Ala Ser Pro Trp Pro Ser Ser Leu
              20                  25                  30        
 Thr Met Ser Lys Arg Gly Met Ser Ser Arg Ala Lys Gly Asp Lys Ala
          35                  40                  45            
 Glu Ala Leu Ala Ala Leu Gln Ala Ala Asn Glu Asp Leu Arg Ala Lys
      50                  55                  60                
 Leu Thr Asp Ile Gln Ile Glu Leu Gln Gln Glu Lys Ser Lys Val Ser
  65                  70                  75                  80
 Lys Val Glu Arg Glu Lys Asn Gln Glu Leu Arg Gln Val Arg Glu His
                  85                  90                  95    
 Glu Gln His Lys Thr Ala Val Leu Leu
             100                 105



      <210> 1728
      <211> 156
      <212> PRT
      <213> Homo sapiens


      <400> 1728
 Phe Val Gln Lys Cys Ser Gly Gly Gly Gly Trp Leu Arg Ala Gly Gly
   1               5                  10                  15    
 Gly Leu Ala Glu Met Glu Asp Leu Val Gln Asp Gly Val Ala Ser Pro
              20                  25                  30        
 Ala Thr Pro Gly Thr Gly Lys Ser Lys Leu Glu Thr Leu Pro Lys Glu
          35                  40                  45            
 Asp Leu Ile Lys Phe Ala Lys Lys Gln Met Met Leu Ile Gln Lys Ala
      50                  55                  60                
 Lys Ser Arg Cys Thr Glu Leu Glu Lys Glu Ile Glu Glu Leu Arg Ser
  65                  70                  75                  80
 Lys Pro Val Thr Glu Gly Thr Gly Asp Ile Ile Lys Ala Leu Thr Glu
                  85                  90                  95    
 Arg Leu Asp Ala Leu Leu Leu Glu Lys Ala Glu Thr Glu Gln Gln Cys
             100                 105                 110        
 Leu Ser Leu Lys Lys Glu Asn Ile Lys Met Lys Gln Glu Val Glu Asp
         115                 120                 125            
 Ser Val Thr Lys Met Gly Asp Ala His Lys Glu Leu Gly Gln Ser His
     130                 135                 140                
 Ile Asn Tyr Val Lys Glu Ile Glu Asn Leu Lys Asn
 145                 150                 155    



      <210> 1729
      <211> 722
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(722)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1729
 Glu Lys Thr Gly Glu Glu Gly Asp Val Ala Leu Leu Pro Gly Pro Gln
   1               5                  10                  15    
 Thr Gly Glu Cys Glu Glu Thr Cys Arg Lys Cys Gln Gly Leu Trp Lys
              20                  25                  30        
 Glu His Asn Gly Leu Thr Cys Glu Glu Leu Ala Glu Lys Asp Asp Ile
          35                  40                  45            
 Lys Tyr Arg Thr Ser Ile Glu Glu Lys Met Thr Ala Ala Arg Ile Arg
      50                  55                  60                
 Lys Cys His Lys Cys Gly Thr Gly Leu Ile Lys Ser Glu Gly Cys Asn
  65                  70                  75                  80
 Arg Met Ser Cys Arg Cys Gly Ala Gln Met Cys Tyr Leu Cys Arg Val
                  85                  90                  95    
 Ser Ile Asn Gly Tyr Asp His Phe Cys Gln His Pro Arg Ser Pro Gly
             100                 105                 110        
 Ala Pro Cys Gln Glu Cys Ser Arg Cys Ser Leu Trp Thr Asp Pro Thr
         115                 120                 125            
 Glu Asp Asp Glu Lys Leu Ile Glu Glu Ile Gln Lys Glu Ala Glu Glu
     130                 135                 140                
 Glu Gln Lys Arg Lys Asn Gly Glu Asn Thr Phe Lys Arg Ile Gly Pro
 145                 150                 155                 160
 Pro Leu Glu Lys Pro Val Glu Lys Val Gln Arg Val Glu Ala Leu Pro
                 165                 170                 175    
 Arg Pro Val Pro Gln Asn Leu Pro Gln Pro Gln Met Pro Pro Tyr Ala
             180                 185                 190        
 Phe Ala His Pro Pro Phe Pro Leu Pro Pro Val Arg Pro Val Phe Asn
         195                 200                 205            
 Asn Phe Pro Leu Asn Met Gly Pro Ile Pro Ala Pro Tyr Val Pro Pro
     210                 215                 220                
 Leu Pro Asn Val Arg Val Asn Tyr Asp Phe Gly Pro Ser Pro His Ala
 225                 230                 235                 240
 Pro Gly Ala Gln Pro Ala His Ala Leu Trp Pro Pro Ala Ala Ala Ser
                 245                 250                 255    
 Pro Ser Asp Gly Pro Glu Ser Pro Leu Arg Ala Gln Ser Pro Phe Gly
             260                 265                 270        
 Val Gly Val Trp Met Glu Asn Pro Pro Pro Arg Leu Val Ser Val Pro
         275                 280                 285            
 Leu His Pro Lys Ser Ala Xaa Arg Val Gly Trp Phe Ser Ser His Pro
     290                 295                 300                
 Phe Pro Arg Arg Ala Thr Ala Pro Gly Arg Val Asp Gly Ser Ile Ile
 305                 310                 315                 320
 Lys Thr Ser Gln Met Val Ala Val Arg Arg Glu Leu Arg Cys Glu Pro
                 325                 330                 335    
 Gly Pro Pro Leu Ala Ser Pro Arg Pro Pro Thr Ala Val Leu Leu Pro
             340                 345                 350        
 Cys Pro Gly Ile Gly His Arg Pro Gly Pro Cys Cys Ser Pro Pro Gly
         355                 360                 365            
 Pro Pro Ser Glu Pro Thr Pro Gly Xaa Gln Gly Ser Arg Glu His Leu
     370                 375                 380                
 Pro Gly Gly Ala His Gly Trp Ala Lys Gly Arg Gly Gly Cys Thr Cys
 385                 390                 395                 400
 Gly Pro Gly Lys His Cys Ser Gly Trp Gly Ala Gly Thr Met Ala Arg
                 405                 410                 415    
 Arg Gly Thr Ala Thr Ala Val Arg Ala Lys Met Leu Ser Pro His Pro
             420                 425                 430        
 Lys Pro Val Pro Pro Leu Gln Xaa Val Leu Arg Ala Pro Leu Leu Pro
         435                 440                 445            
 Ser Tyr Thr Tyr Ser Asp Glu Ala Ala Ala Asp Pro Ser Arg Gly Gly
     450                 455                 460                
 Gly Phe Val Leu Leu Pro Pro Asn Phe Leu Ile Leu Gly Leu Trp Lys
 465                 470                 475                 480
 Val Arg Leu Arg Asn Pro Phe Pro Gly Gln Ala Ala Ala Val His Trp
                 485                 490                 495    
 Met Val Leu Lys Leu Ala His Xaa Lys Ser Leu Leu Arg Gln Leu Gly
             500                 505                 510        
 Gln Arg Pro Gly Gly Pro Ala Gly Gln Pro Asn Cys Trp Gly Arg Pro
         515                 520                 525            
 Phe Leu Pro Pro Trp Val Met Ser Ser Phe Ser Pro Leu Ala Phe Trp
     530                 535                 540                
 Gly Arg Ser Gly Pro Pro Xaa Gly Asp Arg Xaa Pro Trp Val Pro Pro
 545                 550                 555                 560
 Leu Pro Arg Val Cys Pro Gly Cys Ser Gln Trp Leu Leu Lys Ala Gly
                 565                 570                 575    
 Arg Gly Cys Cys Pro Val Ser Pro Met Xaa Arg Ser Leu Pro Phe Ser
             580                 585                 590        
 Trp Ser Gln Leu Ser Ile Ser Ser Ala Leu Pro Cys Pro Pro His Pro
         595                 600                 605            
 Pro Arg Leu Leu Ser Gly Pro Gly Phe Leu Ala Val Pro Glu Ala Ser
     610                 615                 620                
 Leu Trp Pro Ile Asp Arg Xaa Ala Gly Leu Lys Pro Ser Trp Pro Gln
 625                 630                 635                 640
 Ala Ser Leu Ser Pro Pro Pro His Ala Leu Pro Cys Pro Cys Arg Val
                 645                 650                 655    
 Ala Met Gly Phe Xaa Glu Ala Gly Ser Ser Gln Thr Ser Asp Thr Ala
             660                 665                 670        
 Glu Ser Asp Asn His Trp Gly Trp Gly Cys Ile Ser Leu Arg Ser Gly
         675                 680                 685            
 Pro Pro Pro Pro Glu Ala Gly Pro Gly Pro Pro Lys Val Pro Gly Gly
     690                 695                 700                
 Arg Arg Gly Thr Val Ile Arg Leu Pro Leu Val Ser Gln Met Tyr Phe
 705                 710                 715                 720
 Lys Asp
        



      <210> 1730
      <211> 567
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(567)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1730
 Ile Glu Arg Leu Glu Val Pro Leu Gln Asn Ser Arg Val Asn Ala His
   1               5                  10                  15    
 Phe Asn Gln Leu Phe Leu Arg Pro Asn Lys Glu Lys Ile Asp Phe Leu
              20                  25                  30        
 Leu Glu Val Cys Ser Arg Ser Val Asn Leu Glu Lys Ala Ser Glu Ser
          35                  40                  45            
 Leu Lys Gly Asn Met Ala Ala Phe Leu Lys Asn Val Cys Leu Gly Leu
      50                  55                  60                
 Glu Asp Leu Gln Tyr Val Phe Met Ile Ser Ser His Glu Leu Phe Ile
  65                  70                  75                  80
 Thr Leu Leu Lys Asp Glu Glu Arg Lys Leu Leu Val Asp Gln Met Arg
                  85                  90                  95    
 Lys Arg Ser Pro Arg Val Asn Leu Cys Ile Lys Pro Val Thr Ser Phe
             100                 105                 110        
 Tyr Asp Ile Pro Ala Ser Ala Ser Val Asn Ile Gly Gln Leu Glu His
         115                 120                 125            
 Gln Leu Ile Leu Ser Val Asp Pro Trp Arg Ile Arg Gln Ile Leu Ile
     130                 135                 140                
 Glu Leu His Gly Met Thr Ser Glu Arg Gln Phe Trp Thr Val Ser Asn
 145                 150                 155                 160
 Lys Trp Glu Val Pro Ser Val Tyr Ser Gly Val Ile Leu Gly Ile Lys
                 165                 170                 175    
 Asp Asn Leu Thr Lys Asp Leu Val Tyr Ile Leu Met Ala Lys Gly Leu
             180                 185                 190        
 His Cys Ser Thr Val Lys Asp Phe Ser His Ala Lys Gln Leu Phe Ala
         195                 200                 205            
 Val Val Trp Ser Trp Xaa Gln Ser Ser His Arg Ser Phe Val Arg Ser
     210                 215                 220                
 Cys Xaa Met Arg Cys Cys Phe Trp Ile Phe Ile His Thr Lys Leu Gly
 225                 230                 235                 240
 Gln Gly Arg Gln Glu Arg Asp Arg His Pro Thr Leu Xaa Val Glu Tyr
                 245                 250                 255    
 Glu Ala Ile Trp Lys Xaa Gly Leu Pro Asp Ile Ser Leu Arg Gln Gly
             260                 265                 270        
 Ile Thr Glu Glu Cys Val Ala Phe Met Leu Asn Trp Arg Glu Asn Glu
         275                 280                 285            
 Tyr Leu Thr Leu Gln Val Pro Ala Phe Leu Leu Gln Ser Asn Pro Tyr
     290                 295                 300                
 Val Lys Leu Gly Gln Leu Leu Ala Ala Thr Cys Lys Glu Leu Pro Gly
 305                 310                 315                 320
 Pro Lys Glu Ser Arg Arg Thr Ala Lys Asp Leu Trp Glu Val Val Val
                 325                 330                 335    
 Gln Ile Cys Ser Val Ser Ser Gln His Lys Arg Gly Asn Asp Gly Arg
             340                 345                 350        
 Val Ser Leu Ile Lys Gln Arg Glu Ser Thr Leu Gly Ile Met Tyr Arg
         355                 360                 365            
 Ser Glu Leu Leu Ser Phe Ile Lys Lys Leu Arg Glu Pro Leu Val Leu
     370                 375                 380                
 Thr Ile Ile Leu Ser Leu Phe Val Lys Leu His Asn Val Arg Glu Asp
 385                 390                 395                 400
 Ile Val Asn Asp Ile Thr Ala Glu His Ile Ser Ile Trp Pro Ser Ser
                 405                 410                 415    
 Ile Pro Asn Leu Gln Ser Val Asp Phe Glu Ala Val Ala Ile Thr Val
             420                 425                 430        
 Lys Glu Leu Val Arg Tyr Thr Leu Ser Ile Asn Pro Asn Asn His Ser
         435                 440                 445            
 Trp Leu Ile Ile Gln Ala Asp Ile Tyr Phe Ala Thr Asn Gln Tyr Ser
     450                 455                 460                
 Ala Ala Leu His Tyr Tyr Leu Gln Ala Gly Val Cys Cys Ser Asp Phe
 465                 470                 475                 480
 Phe Asn Lys Ala Val Pro Pro Asp Val Tyr Thr Asp Gln Val Ile Lys
                 485                 490                 495    
 Arg Met Ile Lys Cys Cys Ser Leu Leu Asn Cys His Thr Gln Val Ala
             500                 505                 510        
 Ile Leu Cys Gln Phe Leu Glu Glu Ile Asp Tyr Lys Thr Ala Val Xaa
         515                 520                 525            
 Asn Leu Trp Gln Gly Pro Lys Gln Ser Met Met Ala Met Asp Ser Tyr
     530                 535                 540                
 Tyr Asp Leu His Val Gly Met Val Thr Ile Leu Gly Ile Pro Gly Leu
 545                 550                 555                 560
 Ile Phe His Pro Lys Arg Gly
                 565        



      <210> 1731
      <211> 486
      <212> PRT
      <213> Homo sapiens


      <400> 1731
 Ile His Gly Ala Gly Gln Leu Ala Met Thr His Pro Ser His His Leu
   1               5                  10                  15    
 Asn Phe Gly Met Asn Pro Asp His Ala Arg Asn Ser Leu Ser Asn Cys
              20                  25                  30        
 Gly Ile Arg Gln Pro Lys Tyr Gly Asp Arg Lys Val His His Met His
          35                  40                  45            
 Met Arg Lys Lys Gly Ile Asn Thr Leu Ile Asn Ile Met Ser Arg Leu
      50                  55                  60                
 Gly Gln Asp Asp Pro Thr Pro Ser Arg Ile Asn His Asn Glu Arg Leu
  65                  70                  75                  80
 Glu Phe Leu Gly Asp Ala Val Val Glu Phe Leu Thr Ser Val His Leu
                  85                  90                  95    
 Tyr Tyr Leu Phe Pro Ser Leu Glu Glu Gly Gly Leu Ala Thr Tyr Arg
             100                 105                 110        
 Thr Ala Ile Val Gln Asn Gln His Leu Ala Met Leu Ala Lys Lys Leu
         115                 120                 125            
 Glu Leu Asp Arg Phe Met Leu Tyr Ala His Gly Pro Asp Leu Cys Arg
     130                 135                 140                
 Glu Ser Asp Leu Arg His Ala Met Ala Asn Cys Phe Glu Ala Leu Ile
 145                 150                 155                 160
 Gly Ala Val Tyr Leu Glu Gly Ser Leu Glu Glu Ala Lys Gln Leu Phe
                 165                 170                 175    
 Gly Arg Leu Leu Phe Asn Asp Pro Asp Leu Arg Glu Val Trp Leu Asn
             180                 185                 190        
 Tyr Pro Leu His Pro Leu Gln Leu Gln Glu Pro Asn Thr Asp Arg Gln
         195                 200                 205            
 Leu Ile Glu Thr Ser Pro Val Leu Gln Lys Leu Thr Glu Phe Glu Glu
     210                 215                 220                
 Ala Ile Gly Val Ile Phe Thr His Val Arg Leu Leu Ala Arg Ala Phe
 225                 230                 235                 240
 Thr Leu Arg Thr Val Gly Phe Asn His Leu Thr Leu Gly His Asn Gln
                 245                 250                 255    
 Arg Met Glu Phe Leu Gly Asp Ser Ile Met Gln Leu Val Ala Thr Glu
             260                 265                 270        
 Tyr Leu Phe Ile His Phe Pro Asp His His Glu Gly His Leu Thr Leu
         275                 280                 285            
 Leu Arg Ser Ser Leu Val Asn Asn Arg Thr Gln Ala Lys Val Ala Glu
     290                 295                 300                
 Glu Leu Gly Met Gln Glu Tyr Ala Ile Thr Asn Asp Lys Thr Lys Arg
 305                 310                 315                 320
 Pro Val Ala Leu Arg Thr Lys Thr Leu Ala Asp Leu Leu Glu Ser Phe
                 325                 330                 335    
 Ile Ala Ala Leu Tyr Ile Asp Lys Asp Leu Glu Tyr Val His Thr Phe
             340                 345                 350        
 Met Asn Val Cys Phe Phe Pro Arg Leu Lys Glu Phe Ile Leu Asn Gln
         355                 360                 365            
 Asp Trp Asn Asp Pro Lys Ser Gln Leu Gln Gln Cys Cys Leu Thr Leu
     370                 375                 380                
 Arg Thr Glu Gly Lys Glu Pro Asp Ile Pro Leu Tyr Lys Thr Leu Gln
 385                 390                 395                 400
 Thr Val Gly Pro Ser His Ala Arg Thr Tyr Thr Val Ala Val Tyr Phe
                 405                 410                 415    
 Lys Gly Glu Arg Ile Gly Cys Gly Lys Gly Pro Ser Ile Gln Gln Ala
             420                 425                 430        
 Glu Met Gly Ala Ala Met Asp Ala Leu Glu Lys Tyr Asn Phe Pro Gln
         435                 440                 445            
 Met Ala His Gln Lys Arg Phe Ile Glu Arg Lys Tyr Arg Gln Glu Leu
     450                 455                 460                
 Lys Glu Met Arg Trp Glu Arg Glu His Gln Glu Arg Glu Pro Asp Glu
 465                 470                 475                 480
 Thr Glu Asp Ile Lys Lys
                 485    



      <210> 1732
      <211> 263
      <212> PRT
      <213> Homo sapiens


      <400> 1732
 Lys Met Thr Ser Ser Ser Glu Gln Glu Glu Asp Glu Lys Asn Asn Gln
   1               5                  10                  15    
 Ser Ala Thr Pro Arg Gln Thr Gly Pro Ala Thr Thr Met Asn Ser Lys
              20                  25                  30        
 Gly Gln Tyr Pro Thr Gln Pro Thr Tyr Pro Val Gln Pro Pro Gly Asn
          35                  40                  45            
 Pro Val Tyr Pro Gln Thr Leu His Leu Pro Gln Ala Pro Pro Tyr Thr
      50                  55                  60                
 Asp Ala Pro Pro Ala Tyr Ser Glu Leu Tyr Arg Pro Ser Phe Val His
  65                  70                  75                  80
 Pro Gly Ala Ala Thr Val Pro Thr Met Ser Ala Ala Phe Pro Gly Ala
                  85                  90                  95    
 Ser Leu Tyr Leu Pro Met Ala Gln Ser Val Ala Val Gly Pro Leu Gly
             100                 105                 110        
 Ser Thr Ile Pro Met Ala Tyr Tyr Pro Val Gly Pro Ile Tyr Pro Pro
         115                 120                 125            
 Gly Ser Thr Val Leu Gly Gly Lys Gly Gly Tyr Asp Ala Gly Ala Arg
     130                 135                 140                
 Phe Gly Ala Gly Ala Thr Ala Gly Asn Ile Pro Pro Pro Pro Pro Gly
 145                 150                 155                 160
 Cys Pro Pro Asn Ala Ala Gln Leu Ala Val Met Gln Gly Ala Asn Val
                 165                 170                 175    
 Leu Val Thr Gln Arg Lys Gly Asn Phe Phe Met Gly Gly Ser Asp Gly
             180                 185                 190        
 Gly Tyr Thr His Leu Val Arg Asn Gln Gly His Leu Cys Ala Arg Glu
         195                 200                 205            
 Lys Thr Ser His Thr Leu Gln His Phe Ser Gln Cys Asn Cys Phe Ser
     210                 215                 220                
 His Ile Asn Leu Lys Leu Gln Phe Arg His Met Leu Leu Gly Cys Leu
 225                 230                 235                 240
 Ser Gly Ala Gln Thr Phe Arg His Phe Ser Asn Leu Ile Arg Asn His
                 245                 250                 255    
 Val Met Val Ala Val Pro Pro
             260            



      <210> 1733
      <211> 263
      <212> PRT
      <213> Homo sapiens


      <400> 1733
 Lys Met Thr Ser Ser Ser Glu Gln Glu Glu Asp Glu Lys Asn Asn Gln
   1               5                  10                  15    
 Ser Ala Thr Pro Arg Gln Thr Gly Pro Ala Thr Thr Met Asn Ser Lys
              20                  25                  30        
 Gly Gln Tyr Pro Thr Gln Pro Thr Tyr Pro Val Gln Pro Pro Gly Asn
          35                  40                  45            
 Pro Val Tyr Pro Gln Thr Leu His Leu Pro Gln Ala Pro Pro Tyr Thr
      50                  55                  60                
 Asp Ala Pro Pro Ala Tyr Ser Glu Leu Tyr Arg Pro Ser Phe Val His
  65                  70                  75                  80
 Pro Gly Ala Ala Thr Val Pro Thr Met Ser Ala Ala Phe Pro Gly Ala
                  85                  90                  95    
 Ser Leu Tyr Leu Pro Met Ala Gln Ser Val Ala Val Gly Pro Leu Gly
             100                 105                 110        
 Ser Thr Ile Pro Met Ala Tyr Tyr Pro Val Gly Pro Ile Tyr Pro Pro
         115                 120                 125            
 Gly Ser Thr Val Leu Gly Gly Lys Gly Gly Tyr Asp Ala Gly Ala Arg
     130                 135                 140                
 Phe Gly Ala Gly Ala Thr Ala Gly Asn Ile Pro Pro Pro Pro Pro Gly
 145                 150                 155                 160
 Cys Pro Pro Asn Ala Ala Gln Leu Ala Val Met Gln Gly Ala Asn Val
                 165                 170                 175    
 Leu Val Thr Gln Arg Lys Gly Asn Phe Phe Met Gly Gly Ser Asp Gly
             180                 185                 190        
 Gly Tyr Thr His Leu Val Arg Asn Gln Gly His Leu Cys Ala Arg Glu
         195                 200                 205            
 Lys Thr Ser His Thr Leu Gln His Phe Ser Gln Cys Asn Cys Phe Ser
     210                 215                 220                
 His Ile Asn Leu Lys Leu Gln Phe Arg His Met Leu Leu Gly Cys Leu
 225                 230                 235                 240
 Ser Gly Ala Gln Thr Phe Arg His Phe Ser Asn Leu Ile Arg Asn His
                 245                 250                 255    
 Val Met Val Ala Val Pro Pro
             260            



      <210> 1734
      <211> 61
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(61)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1734
 Asn Cys Ser Ser Val Phe Cys Phe Pro Gly Ser Gln Arg Val Gly Ser
   1               5                  10                  15    
 Ile Leu Gly Lys Ser Trp Xaa Gly Trp Val Val Ala Thr Gly Val Trp
              20                  25                  30        
 Leu Leu Asn Pro Leu Lys Ala Val Gly Gln Glu Glu Tyr Ser Leu Lys
          35                  40                  45            
 Met Glu Gly Pro Arg Pro Glu Val Thr Cys Arg His Leu
      50                  55                  60    



      <210> 1735
      <211> 757
      <212> PRT
      <213> Homo sapiens


      <400> 1735
 Gly Glu Leu Arg Val Leu Ala Leu Ala His Gly Glu Leu Ala Cys His
   1               5                  10                  15    
 Ala Val Leu Thr Ala Ser Leu Leu Ser Leu Arg Ser Arg Leu Met Asp
              20                  25                  30        
 Ser Asp Met Asp Tyr Glu Arg Pro Asn Val Glu Thr Ile Lys Cys Val
          35                  40                  45            
 Val Val Gly Asp Asn Ala Val Gly Lys Thr Arg Leu Ile Cys Ala Arg
      50                  55                  60                
 Ala Cys Asn Ala Thr Leu Thr Gln Tyr Gln Leu Leu Ala Thr His Val
  65                  70                  75                  80
 Pro Thr Val Trp Ala Ile Asp Gln Tyr Arg Val Cys Gln Glu Val Leu
                  85                  90                  95    
 Glu Arg Ser Arg Asp Val Val Asp Asp Val Ser Val Ser Leu Arg Leu
             100                 105                 110        
 Trp Asp Thr Phe Gly Asp His His Lys Asp Arg Arg Phe Ala Tyr Gly
         115                 120                 125            
 Arg Ser Asp Val Val Val Leu Cys Phe Ser Ile Ala Asn Pro Asn Ser
     130                 135                 140                
 Leu His His Val Lys Thr Met Trp Tyr Pro Glu Ile Lys His Phe Cys
 145                 150                 155                 160
 Pro Arg Ala Pro Val Ile Leu Val Gly Cys Gln Leu Asp Leu Arg Tyr
                 165                 170                 175    
 Ala Asp Leu Glu Ala Val Asn Arg Ala Arg Arg Pro Leu Ala Arg Pro
             180                 185                 190        
 Ile Lys Pro Asn Glu Ile Leu Pro Pro Glu Lys Gly Arg Glu Val Ala
         195                 200                 205            
 Lys Glu Leu Gly Ile Pro Tyr Tyr Glu Thr Ser Val Val Ala Gln Phe
     210                 215                 220                
 Gly Ile Lys Asp Val Phe Asp Asn Ala Ile Arg Ala Ala Leu Ile Ser
 225                 230                 235                 240
 Arg Arg His Leu Gln Phe Trp Lys Ser His Leu Arg Asn Val Gln Arg
                 245                 250                 255    
 Pro Leu Leu Gln Ala Pro Phe Leu Pro Pro Lys Pro Pro Pro Pro Ile
             260                 265                 270        
 Ile Val Val Pro Asp Pro Pro Ser Ser Ser Glu Glu Cys Pro Ala His
         275                 280                 285            
 Leu Leu Glu Asp Pro Leu Cys Ala Asp Val Ile Leu Val Leu Gln Glu
     290                 295                 300                
 Arg Val Arg Ile Phe Ala His Lys Ile Tyr Leu Ser Thr Ser Ser Ser
 305                 310                 315                 320
 Lys Phe Tyr Asp Leu Phe Leu Met Asp Leu Ser Glu Gly Glu Leu Gly
                 325                 330                 335    
 Gly Pro Ser Glu Pro Gly Gly Thr His Pro Glu Asp His Gln Gly His
             340                 345                 350        
 Ser Asp Gln His His His His His His His His His Gly Arg Asp Phe
         355                 360                 365            
 Leu Leu Arg Ala Ala Ser Phe Asp Val Cys Glu Ser Val Asp Glu Ala
     370                 375                 380                
 Gly Gly Ser Gly Pro Ala Gly Leu Arg Ala Ser Thr Ser Asp Gly Ile
 385                 390                 395                 400
 Leu Arg Gly Asn Gly Thr Gly Tyr Leu Pro Gly Arg Gly Arg Val Leu
                 405                 410                 415    
 Ser Ser Trp Ser Arg Ala Phe Val Ser Ile Gln Glu Glu Met Ala Glu
             420                 425                 430        
 Asp Pro Leu Thr Tyr Lys Ser Arg Leu Met Val Val Val Lys Met Asp
         435                 440                 445            
 Ser Ser Ile Gln Pro Gly Pro Phe Arg Ala Val Leu Lys Tyr Leu Tyr
     450                 455                 460                
 Thr Gly Glu Leu Asp Glu Asn Glu Arg Asp Leu Met His Ile Ala His
 465                 470                 475                 480
 Ile Ala Glu Leu Leu Glu Val Phe Asp Leu Arg Met Met Val Ala Asn
                 485                 490                 495    
 Ile Leu Asn Asn Glu Ala Phe Met Asn Gln Glu Ile Thr Lys Ala Phe
             500                 505                 510        
 His Val Arg Arg Thr Asn Arg Val Lys Glu Cys Leu Ala Lys Gly Thr
         515                 520                 525            
 Phe Ser Asp Val Thr Phe Ile Leu Asp Asp Gly Thr Ile Ser Ala His
     530                 535                 540                
 Lys Pro Leu Leu Ile Ser Ser Cys Asp Trp Met Ala Ala Met Phe Gly
 545                 550                 555                 560
 Gly Pro Phe Val Glu Ser Ser Thr Arg Glu Val Val Phe Pro Tyr Thr
                 565                 570                 575    
 Ser Lys Ser Cys Met Arg Ala Val Leu Glu Tyr Leu Tyr Thr Gly Met
             580                 585                 590        
 Phe Thr Ser Ser Pro Asp Leu Asp Asp Met Lys Leu Ile Ile Leu Ala
         595                 600                 605            
 Asn Arg Leu Cys Leu Pro His Leu Val Ala Leu Thr Glu Gln Tyr Thr
     610                 615                 620                
 Val Thr Gly Leu Met Glu Ala Thr Gln Met Met Val Asp Ile Asp Gly
 625                 630                 635                 640
 Asp Val Leu Val Phe Leu Glu Leu Ala Gln Phe His Cys Ala Tyr Gln
                 645                 650                 655    
 Leu Ala Asp Trp Cys Leu His His Ile Cys Thr Asn Tyr Asn Asn Val
             660                 665                 670        
 Cys Arg Lys Phe Pro Arg Asp Met Lys Ala Met Ser Pro Glu Asn Gln
         675                 680                 685            
 Glu Tyr Phe Glu Lys His Arg Trp Pro Pro Val Trp Tyr Leu Lys Glu
     690                 695                 700                
 Glu Asp His Tyr Gln Arg Ala Arg Lys Glu Arg Glu Lys Glu Asp Tyr
 705                 710                 715                 720
 Leu His Leu Lys Arg Gln Pro Lys Arg Arg Trp Leu Phe Trp Asn Ser
                 725                 730                 735    
 Pro Ser Ser Pro Ser Ser Ser Ala Ala Ser Ser Ser Ser Pro Ser Ser
             740                 745                 750        
 Ser Ser Ala Val Val
         755        



      <210> 1736
      <211> 433
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(433)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1736
 Met Ser Ser Lys Gly Ser Val Val Leu Ala Tyr Ser Gly Gly Leu Asp
   1               5                  10                  15    
 Thr Ser Cys Ile Leu Val Trp Leu Lys Glu Gln Gly Tyr Asp Val Ile
              20                  25                  30        
 Ala Tyr Leu Ala Asn Ile Gly Gln Lys Glu Asp Phe Glu Glu Ala Arg
          35                  40                  45            
 Lys Lys Ala Leu Lys Leu Gly Ala Lys Lys Val Phe Ile Glu Asp Val
      50                  55                  60                
 Ser Arg Glu Phe Val Glu Glu Phe Ile Trp Pro Ala Ile Gln Ser Ser
  65                  70                  75                  80
 Ala Leu Tyr Glu Asp Arg Tyr Leu Leu Gly Thr Phe Phe Ala Arg Pro
                  85                  90                  95    
 Cys Ile Ala Arg Lys Gln Val Glu Ile Ala Gln Arg Glu Gly Ala Lys
             100                 105                 110        
 Tyr Val Ser His Gly Ala Thr Gly Lys Gly Asn Asp Gln Val Arg Phe
         115                 120                 125            
 Glu Leu Ser Cys Tyr Ser Leu Ala Pro Gln Ile Lys Val Ile Ala Pro
     130                 135                 140                
 Trp Arg Met Pro Glu Phe Tyr Asn Arg Phe Lys Gly Arg Asn Asp Leu
 145                 150                 155                 160
 Met Glu Tyr Ala Lys Gln His Gly Ile Pro Ile Pro Val Thr Pro Lys
                 165                 170                 175    
 Asn Pro Trp Ser Met Asp Glu Asn Leu Met His Ile Ser Tyr Glu Ala
             180                 185                 190        
 Gly Ile Leu Glu Asn Pro Lys Asn Gln Ala Pro Pro Gly Leu Tyr Thr
         195                 200                 205            
 Lys Thr Gln Asp Pro Ala Lys Ala Pro Asn Thr Pro Asp Ile Leu Glu
     210                 215                 220                
 Ile Glu Phe Lys Lys Gly Val Pro Val Glu Gly Gly Pro Thr Phe Lys
 225                 230                 235                 240
 Asp Gly Thr Thr His Gln Thr Phe Leu Glu Leu Phe Met Tyr Leu Asn
                 245                 250                 255    
 Glu Val Ala Gly Lys His Gly Val Gly Pro Tyr Leu Thr Ser Trp Glu
             260                 265                 270        
 Asn Arg Phe His Trp Glu Leu Lys Ser Arg Gly Ile Leu Arg Arg Pro
         275                 280                 285            
 Gln Ala Gly Thr Ile Leu Tyr His Ala His Leu Asp Ile Glu Ala Phe
     290                 295                 300                
 Thr Met Gly Gly Asp Arg Ala Gln Ile Pro Asn Gln Gly Leu Gly Phe
 305                 310                 315                 320
 Glu Phe Val Glu Leu Gly Val Tyr Arg Phe Ser Gly Thr Ala Pro Glu
                 325                 330                 335    
 Cys Glu Leu Val Gly Pro Cys Leu Arg Gln Ser Pro Gln Glu Arg Val
             340                 345                 350        
 Glu Gly Lys Ser Ala Gly Val Pro Ser Leu Lys Gly Pro Arg Cys Thr
         355                 360                 365            
 Ser Leu Gly Pro Glu Val Pro His Cys Ser Leu Tyr Asn Glu Glu Leu
     370                 375                 380                
 Val Lys His Gly Thr Cys Gln Gly Asp Tyr Glu Pro Asn Xaa Leu Pro
 385                 390                 395                 400
 Pro Gly Phe Ile Gln Thr Ser Ile Ser Leu Lys Ala Glu Gly Asn Tyr
                 405                 410                 415    
 His Arg Leu Pro Arg Ala Lys Val Thr Ala Gln Ile Arg Pro Arg Val
             420                 425                 430        
 Gln
    



      <210> 1737
      <211> 238
      <212> PRT
      <213> Homo sapiens


      <400> 1737
 Val Pro Arg Val Cys Leu Leu Leu Gln Gln Cys Leu Asp Gly Thr Asp
   1               5                  10                  15    
 Pro Gly Thr Gly Leu Pro Ala Ser Asp Arg Pro Pro Ile Ser Ser Pro
              20                  25                  30        
 Leu Ala Thr Ser Gly Thr Ile Phe Ser Ala Ile Ser Cys Phe Trp Asp
          35                  40                  45            
 Leu Pro Ala Pro Phe Leu Trp Leu Ala Pro Ser Cys Gln Pro Thr Met
      50                  55                  60                
 Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala Val
  65                  70                  75                  80
 Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser
                  85                  90                  95    
 Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val Ser
             100                 105                 110        
 His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg
         115                 120                 125            
 Leu Leu Arg Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp
     130                 135                 140                
 Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met
 145                 150                 155                 160
 Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp
                 165                 170                 175    
 Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe
             180                 185                 190        
 Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met
         195                 200                 205            
 Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly
     210                 215                 220                
 Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr Leu Lys His Asp
 225                 230                 235            



      <210> 1738
      <211> 608
      <212> PRT
      <213> Homo sapiens


      <400> 1738
 Met Ala Ile Leu Arg Ala Arg Ala Ala Glu Ile Leu Phe Gln Glu Thr
   1               5                  10                  15    
 Ala Ala Ser Pro Gln Ala Leu Pro Arg Leu Gln Ala Arg Gln Gly Arg
              20                  25                  30        
 Ala Lys Val Arg Arg Arg Ser Arg Gln Ser Pro Leu Lys Ser Ala Pro
          35                  40                  45            
 Trp Lys Leu Ser Leu Asp His Gly Thr Arg Gly Leu Ala Asn Asp Ile
      50                  55                  60                
 Gly Val Gln Trp Arg Arg Pro Ala Arg Pro Pro Ser Arg Asp Thr Val
  65                  70                  75                  80
 Pro Arg Gly Leu Ala Leu Ala Pro Ala Ser His Ala Met Pro Cys His
                  85                  90                  95    
 Pro Pro His Thr Arg Ala Ser Glu Pro Pro Gly Ala His Leu Gly Thr
             100                 105                 110        
 Gly Lys Val Pro Ala Trp Ser Leu Lys Ser Val Val Arg Cys Glu Gln
         115                 120                 125            
 Arg Arg Val Met Gln Gln Ala Cys Ala Tyr Pro Asp Arg Lys Lys Gly
     130                 135                 140                
 Met Gln Arg Leu Lys Asp Gly Val Cys Ser Ala Cys Ala Gln Thr Thr
 145                 150                 155                 160
 Gly Lys Gln Asp Cys Glu Asn Ala Trp Cys Val Pro Leu Ile Gln Val
                 165                 170                 175    
 Glu Thr Glu Gln Pro Glu Glu Ser Phe Pro Asn Thr Glu Thr Asn Gly
             180                 185                 190        
 Glu Phe Gly Lys Cys Pro Ala Glu Asp Met Glu Glu Glu Gln Ala Leu
         195                 200                 205            
 Lys Arg Ser Arg Asn Thr Asp Glu Met Val Glu Leu His Ile Leu Leu
     210                 215                 220                
 Gln Asn Lys Asn Ser Gly Ala Val Ile Gly Glu Gly Gly Lys Asn Ile
 225                 230                 235                 240
 Lys Ala Pro Cys Ile Asp Tyr Ser Ala Ser Val Ser Val Pro Asp Ser
                 245                 250                 255    
 Ser Gly Pro Lys Cys Ile Leu Ser Ile Ser Ala Gly Ile Glu Thr Ile
             260                 265                 270        
 Gly Glu Ile Leu Lys Lys Ile Ile Pro Thr Leu Glu Glu Gly Leu Gln
         275                 280                 285            
 Leu Pro Leu Leu Thr Pro Thr Ser Gln Leu Leu Leu Glu Ser Asp Ala
     290                 295                 300                
 Val Glu Cys Leu Asn Tyr Gln His Tyr Lys Gly Arg Asp Phe Glu Cys
 305                 310                 315                 320
 Glu Leu Lys Leu Leu Ile Tyr Gln Ser Leu Ala Gly Gly Ile Leu Gly
                 325                 330                 335    
 Ser Lys Glu Cys Cys Ser His Pro Thr Asp Arg Val Val Leu Ile Gly
             340                 345                 350        
 Gly Lys Pro Asn Arg Val Val Glu Cys Ile Lys Ile Ile Leu Asp Leu
         355                 360                 365            
 Ile Ser Glu Ser Pro Ile Lys Gly Pro Ala Gln Pro Tyr Asp Pro Ser
     370                 375                 380                
 Phe Tyr Asn Glu Thr Tyr Asp Tyr Gly Gly Phe Thr Met Met Phe Asp
 385                 390                 395                 400
 Asp Arg Pro Gly Cys Pro Val Gly Phe Pro Met Trp Gly Arg Gly Gly
                 405                 410                 415    
 Phe Asp Arg Met Pro Pro Gly Trp Gly Gly Arg Pro Met Pro Pro Ser
             420                 425                 430        
 Arg Arg Asp Met Ser Pro His Arg Gly Pro Pro Pro Pro Leu Thr Gly
         435                 440                 445            
 Arg Gly Gly Arg Gly Gly Ser Arg Ala Arg Asn Leu Pro Leu Pro Pro
     450                 455                 460                
 Pro Pro Pro Pro Arg Gly Glu Asp Leu Met Ala Tyr Asp Arg Arg Gly
 465                 470                 475                 480
 Arg Pro Gly Asp Cys Tyr Asp Gly Met Val Gly Phe Ser Pro Asp Glu
                 485                 490                 495    
 Thr Trp Asn Ser Ala Ile Asp Thr Trp Ser Pro Ser Glu Trp Gln Met
             500                 505                 510        
 Ala Tyr Glu Pro Gln Gly Gly Ser Gly Tyr Asp Tyr Ser Tyr Ala Gly
         515                 520                 525            
 Ile Gly Gly Ser Tyr Gly Asp Leu Gly Gly Pro Ile Thr Thr Ala Gln
     530                 535                 540                
 Val Thr Ile Pro Lys Asp Leu Thr Gly Ser Ile Ile Gly Lys Gly Gly
 545                 550                 555                 560
 Gln Arg Ile Lys Gln Ile Gly His Glu Leu Gly Ala Ser Ile Lys Ile
                 565                 570                 575    
 Asp Glu Pro Leu Glu Gly Ser Glu Asp Gln Ile Thr Ile Ile Thr Gly
             580                 585                 590        
 Thr Gln Asp Gln Ile Gln Asn Ala Gln Tyr Leu Leu Gln Asn Asn Val
         595                 600                 605            





      <210> 1739
      <211> 176
      <212> PRT
      <213> Homo sapiens


      <400> 1739
 Thr Thr Thr Met Ser Ser Lys Lys Ala Lys Thr Lys Thr Thr Lys Lys
   1               5                  10                  15    
 Arg Pro Gln Arg Ala Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser
              20                  25                  30        
 Gln Ile Gln Glu Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg
          35                  40                  45            
 Asp Gly Phe Ile Asp Lys Glu Asp Leu His Asp Met Leu Ala Ser Leu
      50                  55                  60                
 Gly Lys Asn Pro Thr Asp Ala Tyr Leu Asp Ala Met Met Asn Glu Ala
  65                  70                  75                  80
 Pro Gly Pro Ile Asn Phe Thr Met Phe Leu Thr Met Phe Gly Glu Lys
                  85                  90                  95    
 Leu Asn Gly Thr Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Ala Ser
             100                 105                 110        
 Cys Phe Asp Glu Glu Ala Thr Gly Thr Ile Gln Glu Asp Tyr Leu Arg
         115                 120                 125            
 Glu Leu Leu Thr Thr Met Gly Asp Arg Phe Thr Asp Glu Glu Val Asp
     130                 135                 140                
 Glu Leu Tyr Arg Glu Ala Pro Ile Asp Lys Lys Gly Asn Phe Asn Tyr
 145                 150                 155                 160
 Ile Glu Phe Thr Arg Ile Leu Lys His Gly Ala Lys Asp Lys Asp Asp
                 165                 170                 175    





      <210> 1740
      <211> 154
      <212> PRT
      <213> Homo sapiens


      <400> 1740
 Ser Arg Val Phe Phe Phe Phe Phe Phe Phe Pro Ala Phe Lys Met Ser
   1               5                  10                  15    
 Lys Arg Gly Arg Gly Gly Ser Ser Gly Ala Lys Phe Arg Ile Ser Leu
              20                  25                  30        
 Gly Leu Pro Val Gly Ala Val Ile Asn Cys Ala Asp Asn Thr Gly Ala
          35                  40                  45            
 Lys Asn Leu Tyr Ile Ile Ser Val Lys Gly Ile Lys Gly Arg Leu Asn
      50                  55                  60                
 Arg Leu Pro Ala Ala Gly Val Gly Asp Met Val Met Ala Thr Val Lys
  65                  70                  75                  80
 Lys Gly Lys Pro Glu Leu Arg Lys Lys Val His Pro Ala Val Val Ile
                  85                  90                  95    
 Arg Gln Arg Lys Ser Tyr Arg Arg Lys Asp Gly Val Phe Leu Tyr Phe
             100                 105                 110        
 Glu Asp Asn Ala Gly Val Ile Val Asn Asn Lys Gly Glu Met Lys Gly
         115                 120                 125            
 Ser Ala Ile Thr Gly Pro Val Ala Lys Glu Cys Ala Asp Leu Trp Pro
     130                 135                 140                
 Arg Ile Ala Ser Asn Ala Gly Ser Ile Ala
 145                 150                



      <210> 1741
      <211> 183
      <212> PRT
      <213> Homo sapiens


      <400> 1741
 Gly Ile Ala Leu Met Trp Pro Gln Pro Arg Leu Pro Pro Arg Pro Ala
   1               5                  10                  15    
 Met Ser Glu Glu Thr Arg Gln Ser Lys Leu Ala Ala Ala Lys Lys Lys
              20                  25                  30        
 Leu Arg Glu Tyr Gln Gln Arg Asn Ser Pro Gly Val Pro Thr Gly Ala
          35                  40                  45            
 Lys Lys Lys Lys Lys Ile Lys Asn Gly Ser Asn Pro Glu Thr Thr Thr
      50                  55                  60                
 Ser Gly Gly Cys His Ser Pro Glu Asp Thr Pro Lys Asp Asn Ala Ala
  65                  70                  75                  80
 Thr Leu Gln Pro Ser Asp Asp Thr Val Leu Pro Gly Gly Val Pro Ser
                  85                  90                  95    
 Pro Gly Ala Ser Leu Thr Ser Met Ala Ala Ser Gln Asn His Asp Ala
             100                 105                 110        
 Asp Asn Val Pro Asn Leu Met Asp Glu Thr Lys Thr Phe Ser Ser Thr
         115                 120                 125            
 Glu Ser Leu Arg Gln Leu Ser Gln Gln Leu Asn Gly Leu Val Cys Glu
     130                 135                 140                
 Ser Ala Thr Cys Val Asn Gly Glu Gly Pro Ala Ser Ser Ala Asn Leu
 145                 150                 155                 160
 Lys Asp Leu Glu Ser Arg Tyr Gln Gln Leu Ala Val Thr Leu Asp Ser
                 165                 170                 175    
 Ser Tyr Val Thr Asn Lys Gln
             180            



      <210> 1742
      <211> 1099
      <212> PRT
      <213> Homo sapiens


      <400> 1742
 Met Ala Gly Ala Leu Pro Pro Ala Ser Leu Pro Pro Cys Ser Leu Ile
   1               5                  10                  15    
 Ser Asp Cys Cys Ala Ser Asn Gln Gly Asp Ser Val Gly Leu Gly Ser
              20                  25                  30        
 Ser Glu Pro Gly Ala Gly Tyr Asn Leu Val Val His Arg Phe Leu Ser
          35                  40                  45            
 Arg Ser Glu Lys Arg Ser Ile Arg Val Gly Val Thr Arg Phe Ser Arg
      50                  55                  60                
 Asp Phe Arg Phe Gly Pro Pro Ile Asn Lys Ile Phe Ala Cys Gly Ala
  65                  70                  75                  80
 Asn Gln Arg Gly Arg Leu Ala Ala Ile Leu Ser Gly Pro Ala Gly Glu
                  85                  90                  95    
 Gly Gln Ser Ala Val Ala Arg Leu Thr Gly Lys Lys Lys Asn His Pro
             100                 105                 110        
 Gly Ala Gln Tyr Ala Thr Arg Leu Ser Pro Arg Val Gly Arg Phe Ile
         115                 120                 125            
 Asn Ala Ala Gly Thr Thr Gly Phe Pro Thr Gly Lys Arg Ala Val Ser
     130                 135                 140                
 Ala Thr Gln Leu Met Ser Asn Thr His Arg Leu Lys Ile Phe Gly Asn
 145                 150                 155                 160
 Asp Pro Gln Leu Pro Arg Gly Gly Phe Val Ile Gly Ala Arg Arg Ser
                 165                 170                 175    
 Asn Gly Ser Arg Lys Arg His Tyr Phe Ala Gly Asn Glu Arg Ala Gln
             180                 185                 190        
 Glu Leu Leu Thr Glu Asp Ala Leu Asp Asp Leu Ile Leu Ser Phe Leu
         195                 200                 205            
 Leu Thr Gly Gln Gln Thr Pro Ala Phe Gly Arg Arg Val Ser Gly Val
     210                 215                 220                
 Ile Glu Ile Ala Asp Gly Ser Arg Arg Arg Lys Ala Ala Ala Leu Thr
 225                 230                 235                 240
 Glu Ser Asp Tyr Arg Val Leu Val Gly Glu Leu Asp Asp Glu Gln Met
                 245                 250                 255    
 Ala Ala Leu Ser Arg Leu Gly Asn Asp Tyr Arg Pro Thr Ser Ala Tyr
             260                 265                 270        
 Glu Arg Gly Gln Arg Tyr Ala Ser Pro Leu Gln Asn Glu Phe Ala Gly
         275                 280                 285            
 Asn Ile Ser Ala Leu Ala Asp Ala Glu Asn Ile Ser Arg Lys Ile Ile
     290                 295                 300                
 Thr Arg Cys Ile Asn Thr Ala Lys Leu Pro Lys Ser Val Val Ala Leu
 305                 310                 315                 320
 Phe Ser His Pro Gly Glu Leu Ser Ala Arg Ser Asp Thr Ser Asn Arg
                 325                 330                 335    
 Ser Ile Gln Leu Ala Ser Gly Trp Cys Pro Pro Arg Met Glu Leu Pro
             340                 345                 350        
 Glu Glu Gly Ala Val Phe Asn Leu Cys Ser Phe Ala Ala Phe Thr Ser
         355                 360                 365            
 Asp Thr Phe Arg Asp Phe Ala Asp Phe Gly Pro Pro Ile Thr Gln Asp
     370                 375                 380                
 Phe Arg Leu Leu Gly Gln Thr Ser Val Asp Arg Leu Leu Gln Leu Ser
 385                 390                 395                 400
 Gln Gly Gln Ala Val Lys Gly Asn Gln Leu Leu Pro Val Ser Leu Val
                 405                 410                 415    
 Lys Arg Lys Thr Thr Leu Ala Pro Asn Thr Gln Thr Ala Ser Pro Arg
             420                 425                 430        
 Ala Leu Ala Asp Ser Leu Met Gln Leu Ala Arg Gln Val Ser Arg Leu
         435                 440                 445            
 Glu Ser Gly Gln Asp Phe Ala Asp Phe Gly Thr Thr Ile Lys Gln Asp
     450                 455                 460                
 Phe Arg Leu Leu Gly Gln Thr Ser Val Asp Arg Leu Leu Gln Leu Ser
 465                 470                 475                 480
 Gln Gly Gln Ala Val Lys Gly Asn Gln Leu Leu Pro Val Ser Leu Val
                 485                 490                 495    
 Lys Arg Lys Thr Thr Leu Ala Pro Asn Thr Gln Thr Ala Ser Pro Arg
             500                 505                 510        
 Ala Leu Ala Asp Ser Leu Met Gln Leu Ala Arg Gln Val Ser Arg Leu
         515                 520                 525            
 Glu Ser Gly Gln Asn Lys Asp Pro Thr Gln Trp Ile Ala Thr Phe Gly
     530                 535                 540                
 Ala Thr Ile Thr Pro Pro Ala Val Lys Arg Asn Val Arg Lys Ile Ile
 545                 550                 555                 560
 Leu His Glu Asn Tyr His Arg Glu Thr Asn Glu Asn Asp Thr Ala Leu
                 565                 570                 575    
 Val Gln Leu Ser Thr Gly Val Glu Phe Ser Asn Ile Val Gln Arg Val
             580                 585                 590        
 Cys Leu Pro Asp Ser Ser Ile Lys Leu Pro Pro Lys Thr Ser Val Phe
         595                 600                 605            
 Val Thr Gly Phe Gly Ser Ile Val Asp Asp Ala Ser Leu Pro Pro Cys
     610                 615                 620                
 Ser Leu Ile Ser Asp Cys Cys Ala Ser Asn Gln Gly Asp Ser Val Gly
 625                 630                 635                 640
 Leu Gly Ser Ser Glu Pro Gly Ala Gly Tyr Asn Leu Val Val His Arg
                 645                 650                 655    
 Phe Leu Ser Arg Ser Glu Lys Arg Ser Ile Arg Val Gly Gly Pro Asp
             660                 665                 670        
 Phe Leu Gly Asp Phe Cys Ser Gln Met Gly Thr Asn Thr Gln Pro Tyr
         675                 680                 685            
 Leu Gly Ala Ile Leu Phe Ile Asn Lys Gly Phe Ala Arg Phe Gly Asn
     690                 695                 700                
 Pro Pro Ser Asn Arg Asp Phe Ser Leu Ala Gly Ala Lys Pro Ala Trp
 705                 710                 715                 720
 Thr Arg Leu Leu His Phe Ser Gln Gly Pro Gly Gly Glu Gly Gln Ser
                 725                 730                 735    
 Ala Val Ala Arg Leu Thr Gly Glu Lys Lys Asn His Pro Gly Ala Gln
             740                 745                 750        
 Tyr Ala Asn Arg Leu Ser Pro Arg Val Gly Arg Phe Ile Asn Ala Ala
         755                 760                 765            
 Gly Thr Thr Gly Phe Leu Thr Gly Lys Arg Ala Val Ser Ala Thr Gln
     770                 775                 780                
 Leu Ile Ile Thr Asn Thr Glu Lys Cys Leu Lys Glu Leu Met Lys Leu
 785                 790                 795                 800
 Lys Thr Lys Ala Arg Glu Leu Arg Glu Glu Cys Arg Ser Leu Arg Ser
                 805                 810                 815    
 Arg Cys Asp Gln Leu Glu Glu Arg Val Ser Ala Met Glu Asp Glu Met
             820                 825                 830        
 Asn Glu Met Lys Arg Glu Gly Lys Phe Arg Glu Lys Arg Ile Lys Arg
         835                 840                 845            
 Asn Glu Gln Ser Leu Gln Glu Ile Trp Asp Tyr Val Lys Arg Pro Asn
     850                 855                 860                
 Leu Arg Leu Ile Gly Val Thr Glu Ser Asp Gly Glu Asn Gly Thr Lys
 865                 870                 875                 880
 Leu Glu Asn Thr Leu Gln Asp Ile Ile Gln Glu Asn Phe Pro Asn Leu
                 885                 890                 895    
 Ala Arg Gln Ser Asn Val Gln Met Ser Arg Ile Phe Arg His Ser Ser
             900                 905                 910        
 Val Gly Gly Arg Phe Ile Lys Ser His Val Ile Lys Leu Arg Leu Gly
         915                 920                 925            
 Asn Asp Tyr Arg Pro Pro Arg Ala Tyr Ala Arg Gly Gln Arg Tyr Ala
     930                 935                 940                
 Thr Arg Leu Gln Asn Glu Phe Ala Ala Asn Ile Ser Ala Leu Ala Asp
 945                 950                 955                 960
 Ala Glu Asn Ile Ser Arg Lys Ile Ile Thr Arg Cys Ile Asn Pro Ala
                 965                 970                 975    
 Lys Leu Pro Lys Ser Val Val Ala Phe Phe Ser His Pro Gly Glu Leu
             980                 985                 990        
 Ser Ala Arg Ser Gly Asp Ala Leu Gln Lys Ala Phe Thr Asp Lys Glu
         995                1000                1005            
 Glu Leu Leu Lys Gln Gln Ala Ser Asn Leu His Glu Gln Lys Lys Ala
    1010                1015                1020                
 Gly Val Ile Phe Glu Ala Glu Glu Val Ile Thr Leu Leu Thr Ser Val
1025                1030                1035                1040
 Leu Lys Thr Ser Ser Ala Ser Arg Thr Ser Leu Ser Ser Pro His Gln
                1045                1050                1055    
 Phe Ala Pro Gly Ala Thr Val Leu Tyr Lys Gly Asp Lys Met Val Leu
            1060                1065                1070        
 Asn Leu Asp Arg Ser Arg Val Pro Thr Glu Cys Ile Glu Lys Ile Glu
        1075                1080                1085            
 Ala Ile Leu Lys Glu Leu Glu Lys Pro Ala Pro
    1090                1095                



      <210> 1743
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 1743
 Ala Arg Gln Arg Leu Gly Ser Arg Ala Pro Val Glu Thr Asn Pro Arg
   1               5                  10                  15    
 Asn Ala Thr Gly Glu Ala Gly Gly Ser Pro Pro Pro Trp Gly Ser Pro
              20                  25                  30        
 Ser Arg Pro Ala Glu Thr Asn Thr Pro Arg Ser Pro Ala Leu Trp Gln
          35                  40                  45            
 Gly Ala Trp Gly Asp Ala Pro Leu Ser Leu Pro Ser Pro Leu Arg Pro
      50                  55                  60                
 Glu Cys Thr Pro Thr Val Gly Gly Cys Pro Cys Pro Leu Pro Trp
  65                  70                  75                



      <210> 1744
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 1744
 Met Val Arg Pro Leu Leu Leu Leu Asn Leu His Phe His Leu Pro Ser
   1               5                  10                  15    
 Leu Val Ser Leu Ser Leu Ser Leu Leu Leu Ser Val Ser Leu Ser Leu
              20                  25                  30        
 Val Asn Ala Val Arg Leu Leu Arg Ala Ser Phe Cys Ser Trp Leu Ile
          35                  40                  45            
 Ala Lys Ser Leu Ile Thr Leu Trp Val Arg Pro Ser Gln Ile Gly Lys
      50                  55                  60                
 Leu Lys Ala Leu Ala Ser Ser Thr Thr Ser Met Ala Trp Glu Gly Leu
  65                  70                  75                  80
 Leu Asp Thr Phe Ala Leu Ser Ile Ser Ser Phe Ser Asn Ser Leu Leu
                  85                  90                  95    
 Gly Ile Leu Leu Cys Phe Leu Lys Ser Pro Asn Ile Phe Gln Ala Ser
             100                 105                 110        





      <210> 1745
      <211> 121
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(121)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1745
 Phe Lys Ile Gln Asn Leu Ile Ala Ser Thr Val Arg Thr Val Met Val
   1               5                  10                  15    
 Ala Asp Cys Ser Arg Phe Asp Ser Pro Asp Leu Leu Leu Glu Ala Gly
              20                  25                  30        
 Asp Pro Ala Thr Ser Pro Cys Arg Ile Phe Asp Leu Gly Ser Asp Asn
          35                  40                  45            
 Glu Glu Val Val Ala Ile Pro Asp Pro Ser His Pro Lys Glu Gly Leu
      50                  55                  60                
 Ser Tyr Ser Leu Ser Cys Val Leu Leu Gly Arg Ser Leu Pro Arg Cys
  65                  70                  75                  80
 Leu Ile Ser Cys Tyr Ile Pro Leu Cys Leu Ser Val Ala Ser Gly Pro
                  85                  90                  95    
 His Lys Phe Tyr Xaa Pro His Cys Gln His Arg Pro His Gly Asp Gly
             100                 105                 110        
 Gly Arg Leu Gln Pro Leu Arg Gln Pro
         115                 120    



      <210> 1746
      <211> 141
      <212> PRT
      <213> Homo sapiens


      <400> 1746
 Ser Thr Pro Trp Arg Leu Leu Phe Ser Ser Ser Val Asn Ser Thr Phe
   1               5                  10                  15    
 Pro Thr Met Ser Arg Gln Leu Asn Ile Lys Ser Ser Gly Asp Lys Gly
              20                  25                  30        
 Asn Phe Ser Val His Ser Ala Val Val Pro Arg Lys Ala Val Gly Ser
          35                  40                  45            
 Leu Ala Ser Tyr Cys Ala Ala Gly Arg Gly Ala Gly Ala Gly Phe Gly
      50                  55                  60                
 Ser Arg Ser Leu Tyr Ser Leu Gly Gly Asn Arg Arg Ile Ser Phe Asn
  65                  70                  75                  80
 Val Ala Gly Gly Gly Val Arg Ala Gly Gly Tyr Gly Phe Arg Pro Gly
                  85                  90                  95    
 Ser Gly Tyr Gly Gly Gly Arg Ala Ser Gly Phe Ala Gly Ser Met Phe
             100                 105                 110        
 Gly Ser Val Ala Leu Gly Pro Ala Cys Leu Ser Val Cys Pro Pro Gly
         115                 120                 125            
 Gly Ile His Gln Val Thr Val Asn Lys Ser Leu Leu Ala
     130                 135                 140    



      <210> 1747
      <211> 52
      <212> PRT
      <213> Homo sapiens


      <400> 1747
 Gly Lys Glu Ala Glu Val Leu His Lys Met Leu Val Leu His Asn Ser
   1               5                  10                  15    
 Gln Lys Leu Gln Ile Leu Tyr Lys Ser Leu Glu Lys Ser Ile Pro Glu
              20                  25                  30        
 Ser Ile Lys Val Tyr Gly Ala Ile Phe Asn Ile Lys Asp Lys Asn Pro
          35                  40                  45            
 Phe Asn Met Glu
      50        



      <210> 1748
      <211> 99
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(99)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1748
 Gly Tyr Gln Leu Pro Leu Gln Asp Glu Leu Val Leu Gly Gln Phe Leu
   1               5                  10                  15    
 Phe Gln Val Ser Lys Ile Arg Phe Phe Ser Ala Arg Lys Ile Thr Cys
              20                  25                  30        
 Asn Ser His Phe Leu Leu Leu Lys Phe Phe Xaa Phe Pro His Ile Ile
          35                  40                  45            
 Cys Lys Xaa Val Ser Phe Ser Ser Glu Arg Ala Ala Ala Ala Asp Arg
      50                  55                  60                
 Ala Gly Ala Ser His Pro Arg Ile His His Asn Leu Gln Arg Leu Gln
  65                  70                  75                  80
 Glu Asn Ser Ile Arg Gly Pro Lys Tyr Ser Ser His Thr Val Ser Ala
                  85                  90                  95    
 Asp Ala Trp
            



      <210> 1749
      <211> 175
      <212> PRT
      <213> Homo sapiens


      <400> 1749
 Ala Trp Arg Ala Gly Gly Arg Arg Arg Val Gly Gln Gly Asn Ser Gly
   1               5                  10                  15    
 Leu Gln Ser Pro Cys Trp Gly Phe Gly Glu Arg Leu Asp Pro Gly Phe
              20                  25                  30        
 Trp Asp Ala Ser Gly Glu Gly Ser Thr Gly Phe Ala Phe Ile Arg Pro
          35                  40                  45            
 Lys Met Pro Phe Phe Gly Asn Thr Phe Ser Pro Lys Lys Thr Pro Pro
      50                  55                  60                
 Arg Lys Ser Ala Ser Leu Ser Asn Leu His Ser Leu Asp Arg Ser Thr
  65                  70                  75                  80
 Arg Glu Val Glu Leu Gly Leu Glu Tyr Gly Ser Pro Thr Met Asn Leu
                  85                  90                  95    
 Ala Gly Gln Ser Leu Lys Phe Glu Asn Gly Gln Trp Ile Ala Glu Thr
             100                 105                 110        
 Gly Val Ser Gly Gly Val Asp Arg Arg Glu Val Gln Arg Leu Arg Arg
         115                 120                 125            
 Arg Asn Gln Gln Leu Glu Glu Glu Asn Asn Leu Leu Arg Leu Lys Val
     130                 135                 140                
 Asp Ile Leu Leu Asp Met Leu Ser Glu Ser Thr Ala Glu Ser His Leu
 145                 150                 155                 160
 Met Glu Lys Glu Leu Asp Glu Leu Arg Ile Ser Arg Lys Arg Lys
                 165                 170                 175



      <210> 1750
      <211> 539
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(539)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1750
 Arg Val Leu Pro Cys Ser Ser Glu Thr Glu Ala Leu Pro Glu Glu Gly
   1               5                  10                  15    
 Cys Gln His Pro Arg Gly Thr Ala Ser Pro Gly Gln Asp His Arg His
              20                  25                  30        
 Trp Pro Gly Arg Gln Ser Pro Thr Ala Ser Leu Xaa Ala Ala Pro Pro
          35                  40                  45            
 Arg Gly Tyr Gly His Leu Gln Gln Gln Trp Arg Glu Pro Pro Gly Arg
      50                  55                  60                
 Arg Gly Pro Leu Leu Pro Gly Cys His Leu Pro His Gln Xaa Ala Gly
  65                  70                  75                  80
 Arg Gly Glu Gln Gln Gln Gln Gln Gln Ser Gly Gly Thr Cys Phe Leu
                  85                  90                  95    
 Cys Gln Pro Gly Ala Arg Pro Glu Gln Gln Gln Gln Arg Gly Pro Gly
             100                 105                 110        
 Gln Ser Pro Gly Ala Ser Ser Glu Ala Ser Val Glu Ser Asn Glu Asp
         115                 120                 125            
 Ser Asp His Ala Cys Lys Ser Ser Ala Arg Lys Gln Ala Lys Ser Tyr
     130                 135                 140                
 Met Lys Thr Lys Asn Pro Asp Ser Gln Trp Pro Pro Arg Ala Ala Thr
 145                 150                 155                 160
 Asp Arg Glu Gly Phe Leu Ala Glu Ser Ser Pro Gln Thr Gln Arg Ala
                 165                 170                 175    
 Pro Tyr Ser Gly Pro Gln Asp Leu Ala Ala Leu Leu Glu Gln Ile Gly
             180                 185                 190        
 Cys Leu Lys Tyr Leu Pro Gly Val Xaa Gly Ala Gly Arg Gly Pro Pro
         195                 200                 205            
 His Leu Ser Gly Pro Ser Leu Arg Ala Thr Xaa Arg Lys Leu Ala Ser
     210                 215                 220                
 Arg Cys Leu Gly Pro Arg Gly Arg Xaa Arg Pro Pro Leu Pro Ala Gly
 225                 230                 235                 240
 Gln Gln Cys Pro Pro Thr Arg Gly Cys Pro Gly Ala Gly Leu Arg Arg
                 245                 250                 255    
 Pro Ala Gly Gly Xaa Asp Ala Gly Ala Arg His Pro Ala Ala Gln Ala
             260                 265                 270        
 Leu Arg Gly Gly Arg Gly His Ala Gly Pro Gly Val Ser Gly Ala Gly
         275                 280                 285            
 Ala Ala Arg Arg Gly Gly Glu Leu Pro Ala Gly Ala Gly Pro Arg Pro
     290                 295                 300                
 Arg Gly Pro Pro Gly Pro Ala Ala Gly Asp Val Gly Pro Gly Pro Gly
 305                 310                 315                 320
 Cys Cys Pro Arg Pro Gly Pro Ala Gly Ala Cys Gln Ala Glu Leu Ser
                 325                 330                 335    
 Ser Arg Val Arg Gln Asp Gln Pro Pro Gly Ala Ala Thr Pro Gly Pro
             340                 345                 350        
 Ser Arg Pro Pro Ser Xaa Leu Gln Gly Leu Ala Ser Val Pro Ala Gly
         355                 360                 365            
 His Glu Pro Pro Arg Ala Leu Gly Ser Pro Gly Gly Pro Cys Pro Xaa
     370                 375                 380                
 Asp Gly Ala Ser Thr Val Leu Ser Asp Pro Glu Pro Gly Glu Ala Ala
 385                 390                 395                 400
 Gly Ala Glu Arg Glu Glu Val Ala Gly Asp Leu Ala Cys Gly Pro Asn
                 405                 410                 415    
 Leu Thr Leu Gly Asp Trp Ser Pro Xaa Ser Cys Val Pro Gly Ser Glu
             420                 425                 430        
 Glu Asp Ser Glu Gln Val Ala Ala Met Cys Ser Pro Gly Pro Gly Gly
         435                 440                 445            
 Pro Glu Asp Gln Ala Pro Gly Ala Ala Gly Arg Gln Arg Gln Asp Gly
     450                 455                 460                
 Gly Cys Gly Pro Gly Ser Ala Ala Arg Ala Ser Thr Glu Ala Gly Arg
 465                 470                 475                 480
 Gly Pro His Pro Glu Pro His Gly Glu Ala Gln Ser Ser Trp Ala Ala
                 485                 490                 495    
 Leu Ala His Thr Arg Gln Gly Pro Gly Gly Lys Val Tyr Pro Tyr Thr
             500                 505                 510        
 Arg Thr Gly Ala Asn Xaa Gly Gly Thr Leu Gly Met Arg Thr Gly Ala
         515                 520                 525            
 Pro Gly Lys Cys His Phe Leu Glu Asn Lys Ile
     530                 535                



      <210> 1751
      <211> 155
      <212> PRT
      <213> Homo sapiens


      <400> 1751
 Ser Pro Val Trp Trp Lys Thr Ala Ser Pro Ala Arg Ala Ser Pro Ala
   1               5                  10                  15    
 Leu Ala Ser Leu Ser Arg Ser Ser Ser Gly Arg Ser Ser Ser Ala Arg
              20                  25                  30        
 Ser Ala Ser Val Thr Thr Ser Pro Thr Arg Val Tyr Leu Val Arg Ala
          35                  40                  45            
 Thr Pro Val Gly Ala Val Pro Ile Arg Ser Ser Pro Ala Arg Ser Ala
      50                  55                  60                
 Pro Ala Thr Arg Ala Thr Arg Glu Ser Pro Val Gln Phe Trp Gln Gly
  65                  70                  75                  80
 His Thr Gly Ile Arg Tyr Lys Glu Gln Arg Glu Ser Cys Pro Lys His
                  85                  90                  95    
 Ala Val Arg Cys Asp Gly Val Val Asp Cys Lys Leu Lys Ser Asp Glu
             100                 105                 110        
 Leu Gly Cys Val Arg Ile Asp Trp Asp Lys Ser Leu Leu Lys Ile Tyr
         115                 120                 125            
 Ser Gly Ser Ser His Gln Trp Leu Pro Ile Cys Ser Ser Asn Trp Asn
     130                 135                 140                
 Asp Ser Tyr Ser Glu Lys Thr Cys Gln Gln Leu
 145                 150                 155



      <210> 1752
      <211> 332
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(332)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1752
 Arg Val Gly Met Val Leu Gly Thr Arg Glu Val Gly Asp Ser Thr Pro
   1               5                  10                  15    
 Pro Pro Ser Pro Pro Leu Tyr Pro Phe Thr Gly Asn Glu Phe Val Gln
              20                  25                  30        
 His Asn Thr Trp Gln Leu Ser Arg Val Tyr Pro Ser Asp Leu Arg Thr
          35                  40                  45            
 Asp Ser Ser Asn Tyr Asn Pro Gln Glu Leu Trp Asn Ala Gly Cys Gln
      50                  55                  60                
 Met Val Xaa Gly Gly Ser Arg Asp Trp Glu Glu Gly Val Glu Glu Gln
  65                  70                  75                  80
 Gln Val Gly Asn Lys Phe Ser Ser Asp Gly Arg Val Gly Glu Cys Ser
                  85                  90                  95    
 Arg Lys Leu Leu Gly Xaa Glu Met Leu Ser Val Asp Ile Thr Ser Arg
             100                 105                 110        
 Tyr Arg Ala Pro Ser Thr Tyr Leu Leu Asn Ser Leu Lys Glu Gly Leu
         115                 120                 125            
 Glu Gly Leu His Gly Glu Ser Cys Ser Ser Phe Leu Leu Gly Pro Ser
     130                 135                 140                
 Val Ala Met Asn Met Gln Thr Ala Gly Leu Glu Met Asp Ile Cys Asp
 145                 150                 155                 160
 Gly His Phe Arg Gln Asn Gly Gly Cys Gly Tyr Val Leu Lys Pro Asp
                 165                 170                 175    
 Phe Leu Arg Asp Ile Gln Ser Ser Phe His Pro Glu Lys Pro Ile Ser
             180                 185                 190        
 Pro Phe Lys Ala Gln Thr Leu Leu Asn Gln Val Ile Ser Val Gln Gln
         195                 200                 205            
 Leu Pro Lys Val Asp Lys Thr Lys Glu Gly Ser Ile Val Asp Pro Leu
     210                 215                 220                
 Val Lys Val Gln Ile Phe Gly Val Arg Leu Asp Thr Ala Arg Gln Glu
 225                 230                 235                 240
 Thr Asn Tyr Val Glu Asn Asn Gly Phe Asn Pro Tyr Trp Gly Gln Thr
                 245                 250                 255    
 Leu Cys Phe Arg Val Leu Gly Pro Asp Phe Pro Met Leu Arg Phe Gly
             260                 265                 270        
 Lys Met Asp Tyr Asp Trp Lys Ser Arg Asn Asp Leu Leu Gly Lys Thr
         275                 280                 285            
 Pro Cys Pro Gly Thr Cys Met Gln Gln Gly Tyr Arg His Ile His Leu
     290                 295                 300                
 Leu Ser Lys Asp Gly Ile Ser Leu Arg Pro Ala Ser Ile Phe Val Tyr
 305                 310                 315                 320
 Ile Cys Ile Gln Glu Gly Leu Glu Gly Asp Glu Ser
                 325                 330        


      <210> 1753
      <211> 185
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(185)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1753
 His Pro His Glu Ile Thr Pro Trp Ile Ile Phe Ser Ser Ser Gly Ser
   1               5                  10                  15    
 Ser Ile Phe Phe Ser His Phe Leu Pro Pro Ser Pro Ser Thr Leu Asp
              20                  25                  30        
 Leu Ile Pro Ser Thr Gly Xaa Val Leu Gly Gly Val Glu Phe Lys Glu
          35                  40                  45            
 Ala Phe Gln Leu Phe Asp Arg Thr Gly Asp Gly Lys Ile Leu Tyr Ser
      50                  55                  60                
 Gln Cys Gly Asp Val Met Arg Ala Leu Gly Gln Asn Pro Thr Asn Ala
  65                  70                  75                  80
 Glu Val Leu Lys Val Leu Gly Asn Pro Lys Ser Asp Glu Met Asn Val
                  85                  90                  95    
 Lys Val Leu Asp Phe Glu His Phe Leu Pro Met Leu Gln Thr Val Ala
             100                 105                 110        
 Lys Asn Lys Asp Gln Gly Thr Tyr Glu Asp Tyr Val Glu Gly Leu Arg
         115                 120                 125            
 Val Phe Asp Lys Glu Gly Asn Gly Thr Val Met Gly Ala Glu Ile Arg
     130                 135                 140                
 His Val Leu Val Thr Leu Gly Glu Lys Met Thr Glu Glu Glu Val Glu
 145                 150                 155                 160
 Met Leu Val Ala Gly His Glu Asp Ser Asn Gly Cys Ile Asn Tyr Glu
                 165                 170                 175    
 Ala Phe Val Arg His Ile Leu Ser Gly
             180                 185



      <210> 1754
      <211> 232
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(232)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1754
 Met Thr Arg Gly His Gln Thr Ala Ser Pro Leu Ser Leu Pro Pro Ala
   1               5                  10                  15    
 Ser His Gly Ser Leu Leu Gln His Gln Pro Gly Gly Pro Gly Arg His
              20                  25                  30        
 Thr Ser Cys Thr Gly Ser Arg Trp Cys Trp Lys Ser Ser Lys Glu Leu
          35                  40                  45            
 Thr Glu Leu Met Leu Leu Gly Arg Pro Pro Ser Pro Ser Ser Ala Ser
      50                  55                  60                
 Ser Ser Gly Ser Gly Leu Val Leu Thr His Thr Gly Lys Tyr Phe Ser
  65                  70                  75                  80
 Phe Ser Ser Gly Pro Ala Arg Pro Gly Gly Gly Ala Cys Ser Gly Ser
                  85                  90                  95    
 Cys Gly Gly Ser Val Ser Ala Gly Gln Gly Pro Gly Arg Pro Xaa Arg
             100                 105                 110        
 Trp Ser His Ile Pro Ala Gly Ala Leu Glu Gln Gly Thr Trp His Trp
         115                 120                 125            
 Arg Thr Pro Xaa Trp Pro Ser Cys Cys Pro Xaa Ser Ser Gln Ser Trp
     130                 135                 140                
 Pro Gly Pro Arg Arg Pro Ser Leu Gln Trp Pro Ala Pro Gly Ser Gly
 145                 150                 155                 160
 Ser Ala Leu Pro Ala Ala Glu Asp Val Ser Arg Asp Leu Leu Gln Val
                 165                 170                 175    
 Leu Gln Gly Ile Arg His Leu Leu Asp Gly Leu Leu Ser Pro Gln Val
             180                 185                 190        
 Trp Leu Asp Glu Gly His Gly Ile Gly Leu Thr Cys Gln Gly Val Leu
         195                 200                 205            
 His Pro His Arg Ser His Gly Ala Cys Glu Pro Pro Ser Arg Thr Lys
     210                 215                 220                
 Ser Ser Thr Arg Lys Phe Arg Gly
 225                 230        



      <210> 1755
      <211> 297
      <212> PRT
      <213> Homo sapiens


      <400> 1755
 Lys Arg Phe Gly Tyr Gly Gly Trp Val Gln Leu Gln His His Ser Lys
   1               5                  10                  15    
 Gly Glu Ala Lys Leu Leu Lys Asp Gly Lys Val Phe Arg Val Val Arg
              20                  25                  30        
 Glu Asn Cys Trp Asp Pro Glu Val Arg Ile Arg Glu Met Asp Gln Lys
          35                  40                  45            
 Gly Val Thr Val Gln Ala Leu Ser Thr Val Pro Val Met Phe Ser Tyr
      50                  55                  60                
 Trp Ala Lys Pro Glu Asp Thr Leu Asn Leu Cys Gln Leu Leu Asn Asn
  65                  70                  75                  80
 Asp Leu Ala Ser Thr Val Val Ser Tyr Pro Arg Arg Phe Val Gly Leu
                  85                  90                  95    
 Gly Thr Leu Pro Met Gln Ala Pro Glu Leu Ala Val Lys Glu Met Glu
             100                 105                 110        
 Arg Cys Val Lys Glu Leu Gly Phe Pro Gly Val Gln Ile Gly Thr His
         115                 120                 125            
 Val Asn Glu Trp Asp Leu Asn Ala Gln Glu Leu Phe Pro Val Tyr Ala
     130                 135                 140                
 Ala Ala Glu Arg Leu Lys Cys Ser Leu Phe Val His Pro Trp Asp Met
 145                 150                 155                 160
 Gln Met Asp Gly Arg Met Ala Lys Tyr Trp Leu Pro Trp Leu Val Gly
                 165                 170                 175    
 Met Pro Ala Glu Thr Thr Ile Ala Ile Cys Ser Met Ile Met Gly Gly
             180                 185                 190        
 Val Phe Glu Lys Phe Pro Lys Leu Lys Val Cys Phe Ala His Gly Gly
         195                 200                 205            
 Gly Ala Phe Pro Phe Thr Val Gly Arg Ile Ser His Gly Phe Ser Met
     210                 215                 220                
 Arg Pro Asp Leu Cys Ala Gln Asp Asn Pro Met Asn Pro Lys Lys Tyr
 225                 230                 235                 240
 Leu Gly Ser Phe Tyr Thr Asp Ala Leu Val His Asp Pro Leu Ser Pro
                 245                 250                 255    
 Gln Ala Val Asn Gln Met Ser Ile Gly Lys Asp Lys Val Ile Leu Gly
             260                 265                 270        
 Asn Pro Ile Thr Pro Leu Ser Pro Leu Gly Glu Leu Gly Pro Pro Gly
         275                 280                 285            
 Asn Leu Ile Glu Ser His Gly Arg Ile
     290                 295        



      <210> 1756
      <211> 550
      <212> PRT
      <213> Homo sapiens


      <400> 1756
 Ile Leu Glu Gln Val Val Asn Cys Arg Asp Ala Leu Ala Gln Glu Tyr
   1               5                  10                  15    
 Leu Met Glu Cys Ile Ile Gln Val Phe Pro Asp Glu Phe His Leu Gln
              20                  25                  30        
 Thr Leu Asn Pro Phe Leu Arg Ala Cys Ala Glu Leu His Gln Asn Val
          35                  40                  45            
 Asn Val Lys Asn Ile Ile Ile Ala Leu Ile Asp Arg Leu Ala Leu Phe
      50                  55                  60                
 Ala His Arg Glu Asp Gly Pro Gly Ile Pro Ala Asp Ile Lys Leu Phe
  65                  70                  75                  80
 Asp Ile Phe Ser Gln Gln Val Ala Thr Val Ile Gln Ser Arg Gln Asp
                  85                  90                  95    
 Met Pro Ser Glu Asp Val Val Ser Leu Gln Val Ser Leu Ile Asn Leu
             100                 105                 110        
 Ala Met Lys Cys Tyr Pro Asp Arg Val Asp Tyr Val Asp Lys Val Leu
         115                 120                 125            
 Glu Thr Thr Val Glu Ile Phe Asn Lys Leu Asn Leu Glu His Ile Ala
     130                 135                 140                
 Thr Ser Ser Ala Val Ser Lys Glu Leu Thr Arg Leu Leu Lys Ile Pro
 145                 150                 155                 160
 Val Asp Thr Tyr Asn Asn Ile Leu Thr Val Leu Lys Leu Lys His Phe
                 165                 170                 175    
 His Pro Leu Phe Glu Tyr Phe Asp Tyr Glu Ser Arg Lys Ser Met Ser
             180                 185                 190        
 Cys Tyr Val Leu Ser Asn Val Leu Asp Tyr Asn Thr Glu Ile Val Ser
         195                 200                 205            
 Gln Asp Gln Val Asp Ser Ile Met Asn Leu Val Ser Thr Leu Ile Gln
     210                 215                 220                
 Asp Gln Pro Asp Gln Pro Val Glu Asp Pro Asp Pro Glu Asp Phe Ala
 225                 230                 235                 240
 Asp Glu Gln Ser Leu Val Gly Arg Phe Ile His Leu Leu Arg Ser Glu
                 245                 250                 255    
 Asp Pro Asp Gln Gln Tyr Leu Ile Leu Asn Thr Ala Arg Lys His Phe
             260                 265                 270        
 Gly Ala Gly Gly Asn Gln Arg Ile Arg Phe Thr Leu Pro Pro Leu Val
         275                 280                 285            
 Phe Ala Ala Tyr Gln Leu Ala Phe Arg Tyr Lys Glu Asn Ser Lys Trp
     290                 295                 300                
 Met Thr Asn Gly Lys Arg Asn Ala Arg Arg Phe Phe His Leu Pro His
 305                 310                 315                 320
 Gln Thr Ile Ser Ala Leu Ile Lys Ala Glu Leu Ala Glu Leu Pro Leu
                 325                 330                 335    
 Arg Leu Phe Leu Gln Gly Ala Leu Ala Ala Gly Glu Ile Gly Phe Glu
             340                 345                 350        
 Asn His Glu Thr Val Ala Tyr Glu Phe Met Ser Gln Ala Phe Ser Leu
         355                 360                 365            
 Tyr Glu Asp Glu Ile Ser Asp Ser Lys Ala Gln Leu Ala Ala Ile Thr
     370                 375                 380                
 Leu Ile Ile Gly Thr Phe Glu Arg Met Lys Cys Phe Ser Glu Glu Asn
 385                 390                 395                 400
 His Glu Pro Leu Arg Thr Gln Cys Ala Leu Ala Ala Ser Lys Leu Leu
                 405                 410                 415    
 Lys Lys Pro Asp Gln Ala Glu Arg Glu His Leu Cys Thr Ser Leu Trp
             420                 425                 430        
 Ser Gly Arg Asn Thr Asp Lys Asn Gly Glu Glu Leu His Gly Gly Lys
         435                 440                 445            
 Arg Val Met Glu Cys Leu Lys Lys Ala Leu Lys Ile Ala Asn Gln Cys
     450                 455                 460                
 Met Asp Pro Ser Leu Gln Val Gln Leu Phe Ile Glu Ile Leu Asn Arg
 465                 470                 475                 480
 Tyr Ile Tyr Phe Tyr Glu Lys Glu Asn Asp Ala Val Thr Ile Gln Val
                 485                 490                 495    
 Leu Asn Gln Leu Ile Gln Lys Ile Arg Glu Asp Leu Pro Asn Leu Glu
             500                 505                 510        
 Ser Ser Glu Glu Thr Glu Gln Ile Asn Lys His Phe His Asn Thr Leu
         515                 520                 525            
 Glu His Leu Arg Leu Arg Arg Glu Ser Pro Glu Ser Glu Gly Pro Ile
     530                 535                 540                
 Tyr Glu Gly Leu Ile Leu
 545                 550



      <210> 1757
      <211> 37
      <212> PRT
      <213> Homo sapiens


      <400> 1757
 His Ile Glu Glu Leu Arg Glu Leu Gln Pro Lys Ile Asn Glu Ala Ile
   1               5                  10                  15    
 Val Ala Val Gln Thr Ile Ile Thr Asp Pro Arg Thr Asp His Arg Leu
              20                  25                  30        
 Gly Lys Val Gly Arg
          35        



      <210> 1758
      <211> 227
      <212> PRT
      <213> Homo sapiens


      <400> 1758
 Asp Ser Phe Phe Cys Ser Glu Leu Gln Leu Ala Gln Leu Leu Ala Glu
   1               5                  10                  15    
 Leu Asn Ser Met Pro Asp Phe Phe Pro Val Arg Thr Pro Thr Ser Ala
              20                  25                  30        
 Ser Arg Lys Lys Thr Val Arg Arg Ala Phe Ser Glu Gly Gln Ile Thr
          35                  40                  45            
 Arg Arg Met Asn Pro Thr Arg Ser Ala Arg Pro Pro Glu Lys Phe Ala
      50                  55                  60                
 Leu Glu Asn Phe Thr Val Ser Ala Ala Lys Phe Ala Glu Glu Phe Tyr
  65                  70                  75                  80
 Ser Phe Arg Arg Arg Lys Thr Ile Gly Gly Lys Cys Arg Glu Tyr Arg
                  85                  90                  95    
 Arg Arg His Arg Ile Ser Ser Phe Arg Pro Val Glu Asp Ile Thr Glu
             100                 105                 110        
 Glu Asp Leu Glu Asn Val Ala Ile Thr Val Arg Asp Lys Ile Tyr Asp
         115                 120                 125            
 Lys Val Leu Gly Asn Thr Cys His Gln Cys Arg Gln Lys Thr Ile Asp
     130                 135                 140                
 Thr Lys Thr Val Cys Arg Asn Gln Gly Cys Cys Gly Val Arg Gly Gln
 145                 150                 155                 160
 Phe Cys Gly Pro Cys Leu Arg Asn Arg Tyr Gly Glu Asp Val Arg Ser
                 165                 170                 175    
 Ala Leu Leu Asp Pro Asp Trp Val Cys Pro Pro Cys Arg Gly Ile Cys
             180                 185                 190        
 Asn Cys Ser Tyr Cys Arg Lys Arg Asp Gly Arg Cys Ala Thr Gly Ile
         195                 200                 205            
 Leu Ile His Leu Ala Lys Phe Tyr Gly Tyr Asp Asn Val Lys Glu Tyr
     210                 215                 220                
 Leu Glu Arg
 225        



      <210> 1759
      <211> 286
      <212> PRT
      <213> Homo sapiens


      <400> 1759
 Met Lys Lys Glu Asp Ala Phe Leu Lys Ala Phe Tyr Ile Val His Gly
   1               5                  10                  15    
 Lys Trp Asn Cys Val Lys Gly Ser Leu Thr Arg Thr Pro Cys Cys Cys
              20                  25                  30        
 Thr Asn Cys Leu Ala Gly Gly Ile Trp Cys Met Arg Val Gln Ile Phe
          35                  40                  45            
 Gln Leu Glu Asn Lys Val Leu Pro Gly Phe Pro Trp Ala Cys Arg Val
      50                  55                  60                
 Asp Leu Tyr Gly Gln Ile Gly Phe Asp Ala Ala Ala Gln Cys Leu Ser
  65                  70                  75                  80
 Leu Ser Val Ser Lys Ala Glu Pro Leu Val Lys Lys Ala Pro Pro Glu
                  85                  90                  95    
 Leu Arg Glu Gln Leu Ala Arg Lys Thr Leu Ser Ser Asp Asn Leu Lys
             100                 105                 110        
 Tyr Leu Phe Asp Asn Lys Asp Ile Met Lys Val Lys Gln Ser Lys Lys
         115                 120                 125            
 Lys Lys Glu His Ser Phe Arg Lys Asn Asn Gly Cys Ile Lys Ile Ile
     130                 135                 140                
 Ala Phe Ser Asp His Ala Glu Asp Phe Arg Lys Leu Gly Cys Glu Val
 145                 150                 155                 160
 Leu Gly Ile Ser Val Asp Ser Gln Phe Thr His Leu Ala Trp Ile Asn
                 165                 170                 175    
 Asn Pro Gln Arg Glu Gly Asp Leu Gly Pro Leu Asn Ile Pro Leu Leu
             180                 185                 190        
 Ala Glu Val Ala Ser Gly Leu Ser Glu Asp Tyr Ala Val Leu Lys Thr
         195                 200                 205            
 Asp Ala Gly Ile Ala Tyr Arg Gly Arg Phe Ile Ser Asp Gly Lys Gly
     210                 215                 220                
 Val Leu Ser Gln Ile Thr Val Asn Asp Leu Pro Val Gly Arg Ser Val
 225                 230                 235                 240
 Asp Glu Ala Leu Arg Leu Val Gln Ala Phe Gln Tyr Ala Glu Glu His
                 245                 250                 255    
 Ala Glu Val Cys Pro Ala Gly Trp Lys Pro Gly Thr Asp Thr Ile Lys
             260                 265                 270        
 Leu Asn Val Gly Asp Ser Lys Glu Asn Leu Ser Lys His Asn
         275                 280                 285    



      <210> 1760
      <211> 297
      <212> PRT
      <213> Homo sapiens


      <400> 1760
 Leu Cys Pro Ser Leu Leu Leu Ala Gly Ser Ser Ala Gln Thr Gln Ala
   1               5                  10                  15    
 Pro His Cys Ser Met Asp Thr Pro Ser Pro Asp Pro Leu Pro Ser Pro
              20                  25                  30        
 Leu Pro Gly Glu Glu Glu Lys Pro Leu Ala Leu Ser Pro Pro Val Pro
          35                  40                  45            
 Arg Gly Arg Arg Gly Arg Arg Pro Gly Gly Ala Thr Ser Ser Asn Arg
      50                  55                  60                
 Thr Leu Lys Ala Ser Leu Pro Arg Lys Arg Gly Arg Pro Pro Lys Ser
  65                  70                  75                  80
 Gly Gln Glu Pro Pro Leu Val Gln Val Gln Gly Val Thr Ala Pro Val
                  85                  90                  95    
 Gly Ser Ser Gly Gly Ser Asp Leu Leu Leu Ile Asp Asp Gln Gly Val
             100                 105                 110        
 Pro Tyr Thr Val Ser Glu Gly Ser Ala Ala Gly Pro Glu Gly Ser Gly
         115                 120                 125            
 Pro Arg Lys Ala Pro His Phe Cys Pro Val Cys Leu Arg Ala Phe Pro
     130                 135                 140                
 Tyr Leu Ser Asp Leu Glu Arg His Ser Ile Ser His Ser Glu Leu Lys
 145                 150                 155                 160
 Pro His Gln Cys Lys Val Cys Gly Lys Thr Phe Lys Arg Ser Ser His
                 165                 170                 175    
 Leu Arg Arg His Cys Asn Ile His Ala Gly Leu Arg Pro Phe Arg Cys
             180                 185                 190        
 Pro Leu Cys Pro Arg Arg Phe Arg Glu Ala Gly Glu Leu Ala His His
         195                 200                 205            
 His Arg Val His Ser Gly Glu Arg Pro Tyr Gln Cys Pro Ile Cys Arg
     210                 215                 220                
 Leu Arg Phe Thr Glu Ala Asn Thr Leu Arg Arg His Ala Lys Arg Lys
 225                 230                 235                 240
 His Pro Glu Ala Met Gly Val Pro Leu Cys Ala Pro Asp Pro Gly Ser
                 245                 250                 255    
 Glu Pro Pro Cys Gly Arg Gly Gly His Pro Gly His Ser Arg Gly Arg
             260                 265                 270        
 Gly Arg Gly Gly Asp Arg Gly Glu Arg Gly Ala Gly Leu Thr His Thr
         275                 280                 285            
 Pro Gly His Arg Ser Leu Gly Gln Val
     290                 295        



      <210> 1761
      <211> 651
      <212> PRT
      <213> Homo sapiens


      <400> 1761
 Ala Ala Ser Met Glu His Ile Gln Gly Ala Trp Lys Thr Ile Ser Asn
   1               5                  10                  15    
 Gly Phe Gly Phe Lys Asp Ala Val Phe Asp Gly Ser Ser Cys Ile Ser
              20                  25                  30        
 Pro Thr Ile Val Gln Gln Phe Gly Tyr Gln Arg Arg Ala Ser Asp Asp
          35                  40                  45            
 Gly Lys Leu Thr Asp Pro Ser Lys Thr Ser Asn Thr Ile Arg Val Phe
      50                  55                  60                
 Leu Pro Asn Lys Gln Arg Thr Val Val Asn Val Arg Asn Gly Met Ser
  65                  70                  75                  80
 Leu His Asp Cys Leu Met Lys Ala Leu Lys Val Arg Gly Leu Gln Pro
                  85                  90                  95    
 Glu Cys Cys Ala Val Phe Arg Leu Leu His Glu His Lys Gly Lys Lys
             100                 105                 110        
 Ala Arg Leu Asp Trp Asn Thr Asp Ala Ala Ser Leu Ile Gly Glu Glu
         115                 120                 125            
 Leu Gln Val Asp Phe Leu Asp His Val Pro Leu Thr Thr His Asn Phe
     130                 135                 140                
 Ala Arg Lys Thr Phe Leu Lys Leu Ala Phe Cys Asp Ile Cys Gln Lys
 145                 150                 155                 160
 Phe Leu Leu Asn Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His
                 165                 170                 175    
 Glu His Cys Ser Thr Lys Val Pro Thr Met Cys Val Asp Trp Ser Asn
             180                 185                 190        
 Ile Arg Gln Leu Leu Leu Phe Pro Asn Ser Thr Ile Gly Asp Ser Gly
         195                 200                 205            
 Val Pro Ala Leu Pro Ser Leu Thr Met Arg Arg Met Arg Glu Ser Val
     210                 215                 220                
 Ser Arg Met Pro Val Ser Ser Gln His Arg Tyr Ser Thr Pro His Ala
 225                 230                 235                 240
 Phe Thr Phe Asn Thr Ser Ser Pro Ser Ser Glu Gly Ser Leu Ser Gln
                 245                 250                 255    
 Arg Gln Arg Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr
             260                 265                 270        
 Leu Pro Val Asp Ser Arg Met Ile Glu Asp Ala Ile Arg Ser His Ser
         275                 280                 285            
 Glu Ser Ala Ser Pro Ser Ala Leu Ser Ser Ser Pro Asn Asn Leu Ser
     290                 295                 300                
 Pro Thr Gly Trp Ser Gln Pro Lys Thr Pro Val Pro Ala Gln Arg Glu
 305                 310                 315                 320
 Arg Ala Pro Val Ser Gly Thr Gln Glu Lys Asn Lys Ile Arg Pro Arg
                 325                 330                 335    
 Gly Gln Arg Asp Ser Ser Tyr Tyr Trp Glu Ile Glu Ala Ser Glu Val
             340                 345                 350        
 Met Leu Ser Thr Arg Ile Gly Ser Gly Ser Phe Gly Thr Val Tyr Lys
         355                 360                 365            
 Gly Lys Trp His Gly Asp Val Ala Val Lys Ile Leu Lys Val Val Asp
     370                 375                 380                
 Pro Thr Pro Glu Gln Phe Gln Ala Phe Arg Asn Glu Val Ala Val Leu
 385                 390                 395                 400
 Arg Lys Thr Arg His Val Asn Ile Leu Leu Phe Met Gly Tyr Met Thr
                 405                 410                 415    
 Lys Asp Asn Leu Ala Ile Val Thr Gln Trp Cys Glu Gly Ser Ser Leu
             420                 425                 430        
 Tyr Lys His Leu His Val Gln Glu Thr Lys Phe Gln Met Phe Gln Leu
         435                 440                 445            
 Ile Asp Ile Ala Arg Gln Thr Ala Gln Gly Met Asp Tyr Leu His Ala
     450                 455                 460                
 Lys Asn Ile Ile His Arg Asp Met Lys Ser Asn Asn Ile Phe Leu His
 465                 470                 475                 480
 Glu Gly Leu Thr Val Lys Ile Gly Asp Phe Gly Leu Ala Thr Val Lys
                 485                 490                 495    
 Ser Arg Trp Ser Gly Ser Gln Gln Val Glu Gln Pro Thr Gly Ser Val
             500                 505                 510        
 Leu Trp Met Ala Pro Glu Val Ile Arg Met Gln Asp Asn Asn Pro Phe
         515                 520                 525            
 Ser Phe Gln Ser Asp Val Tyr Ser Tyr Gly Ile Val Leu Tyr Glu Leu
     530                 535                 540                
 Met Thr Gly Glu Leu Pro Tyr Ser His Ile Asn Asn Arg Asp Gln Ile
 545                 550                 555                 560
 Ile Phe Met Val Gly Arg Gly Tyr Ala Ser Pro Asp Leu Ser Lys Leu
                 565                 570                 575    
 Tyr Lys Asn Cys Pro Lys Ala Met Lys Arg Leu Val Ala Asp Cys Val
             580                 585                 590        
 Lys Lys Val Lys Glu Glu Arg Pro Leu Phe Pro Gln Ile Leu Ser Ser
         595                 600                 605            
 Ile Glu Leu Leu Gln His Ser Leu Pro Lys Ile Asn Arg Ser Ala Ser
     610                 615                 620                
 Glu Pro Ser Leu His Arg Ala Ala His Thr Glu Asp Ile Asn Ala Cys
 625                 630                 635                 640
 Thr Leu Thr Thr Ser Pro Arg Leu Pro Val Phe
                 645                 650    



      <210> 1762
      <211> 305
      <212> PRT
      <213> Homo sapiens


      <400> 1762
 Ala Asp Thr Leu Tyr Ser Gln Ile Lys Glu Asp Val Lys Lys Arg Ala
   1               5                  10                  15    
 Val Ala Leu Asp Glu Ala Ile Ser Gln Ser Thr Gln Phe His Asp Lys
              20                  25                  30        
 Ile Asp Gln Ile Leu Glu Ser Leu Glu Arg Ile Val Glu Arg Leu Arg
          35                  40                  45            
 Gln Pro Pro Ser Ile Ser Ala Glu Val Glu Lys Ile Lys Glu Gln Ile
      50                  55                  60                
 Ser Glu Asn Lys Asn Val Ser Val Asp Met Glu Lys Leu Gln Pro Leu
  65                  70                  75                  80
 Tyr Glu Thr Leu Lys Gln Arg Gly Glu Glu Met Ile Ala Arg Ser Gly
                  85                  90                  95    
 Gly Thr Asp Lys Asp Ile Ser Ala Lys Ala Val Gln Asp Lys Leu Asp
             100                 105                 110        
 Gln Met Val Phe Ile Trp Glu Asn Ile His Thr Leu Val Glu Glu Arg
         115                 120                 125            
 Glu Ala Lys Leu Leu Asp Val Met Glu Leu Ala Glu Lys Phe Trp Cys
     130                 135                 140                
 Asp His Met Ser Leu Ile Val Thr Ile Lys Asp Thr Gln Asp Phe Ile
 145                 150                 155                 160
 Arg Asp Leu Glu Asp Pro Gly Ile Asp Pro Ser Val Val Lys Gln Gln
                 165                 170                 175    
 Gln Glu Ala Ala Glu Thr Ile Arg Glu Glu Ile Asp Gly Leu Gln Glu
             180                 185                 190        
 Glu Leu Asp Ile Val Ile Asn Leu Gly Ser Glu Leu Ile Ala Ala Cys
         195                 200                 205            
 Gly Glu Pro Asp Lys Pro Ile Val Lys Lys Ser Ile Asp Glu Leu Asn
     210                 215                 220                
 Ser Ala Trp Asp Ser Leu Asn Lys Ala Trp Lys Asp Arg Ile Asp Lys
 225                 230                 235                 240
 Leu Glu Glu Ala Met Gln Ala Ala Val Gln Tyr Gln Asp Gly Leu Gln
                 245                 250                 255    
 Ala Val Phe Asp Trp Val Asp Ile Ala Gly Gly Lys Leu Ala Ser Met
             260                 265                 270        
 Ser Pro Ile Gly Thr Asp Leu Glu Thr Val Lys Gln Gln Ile Glu Glu
         275                 280                 285            
 Leu Lys Gln Phe Lys Ser Glu Ala Tyr Gln Gln Gln Ile Glu Met Glu
     290                 295                 300                
 Arg
 305



      <210> 1763
      <211> 148
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(148)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1763
 Ala Arg Gly Asp Phe Ser Leu Thr Leu Arg Arg His His Cys His Ala
   1               5                  10                  15    
 Cys Gly Lys Ile Val Cys Arg Asn Cys Ser Arg Asn Lys Tyr Pro Leu
              20                  25                  30        
 Lys Tyr Leu Lys Asp Arg Met Ala Lys Val Cys Asp Gly Cys Phe Gly
          35                  40                  45            
 Glu Leu Lys Lys Arg Gly Arg Ala Val Pro Gly Leu Met Arg Glu Arg
      50                  55                  60                
 Pro Val Ser Met Ser Phe Pro Leu Ser Ser Pro Arg Phe Ser Gly Ser
  65                  70                  75                  80
 Ala Phe Val Ile Arg Leu Pro Glu His Xaa Pro Leu Asp Leu Gln Glu
                  85                  90                  95    
 Ala Glu Glu Ser Pro Phe Ser Pro Asp Arg Gly Lys Ala Gly Arg Ala
             100                 105                 110        
 Thr Gln Val Gly Ser Arg Ala Phe Gly Arg Phe Met Val Ile Leu Gly
         115                 120                 125            
 Arg Arg Ser Gln Thr Leu Pro Cys Pro Ser Leu Thr Ser Leu Phe Gln
     130                 135                 140                
 Thr Glu His Ser
 145            



      <210> 1764
      <211> 279
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(279)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1764
 Arg Phe Arg His Glu Gly Tyr Phe Ser Ser Val Asn Lys Pro Ser Asp
   1               5                  10                  15    
 Glu Val Ser Phe Tyr Xaa Lys Arg Thr Ser Val Thr Pro His Gln Arg
              20                  25                  30        
 Leu His Phe Val Asp Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala
          35                  40                  45            
 Phe Arg Val Arg Gln Gln Leu Thr Phe His His Arg Ile His Thr Gly
      50                  55                  60                
 Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Met Ala Phe Arg Gln Thr
  65                  70                  75                  80
 Ala His Leu Thr Arg His Gln Arg Leu His Ser Gly Glu Lys Leu Tyr
                  85                  90                  95    
 Glu Cys Lys Glu Cys Gly Glu Ala Phe Ile Cys Gly Ala Asp Leu Arg
             100                 105                 110        
 Val His Gln Lys Met His Ile Gly Glu Lys Pro Tyr Glu Cys Lys Glu
         115                 120                 125            
 Cys Gly Lys Ala Phe Arg Val Arg Gly Gln Leu Thr Leu His Gln Arg
     130                 135                 140                
 Ile His Thr Gly Glu Lys Pro Tyr Val Cys Lys Glu Cys Gly Lys Ala
 145                 150                 155                 160
 Phe Arg Gln Tyr Ala His Leu Thr Arg His Gln Lys Leu Asn Ser Ala
                 165                 170                 175    
 Asp Arg Leu Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Leu Cys Gly
             180                 185                 190        
 Ser Gly Leu Arg Val His His Lys Leu His Thr Gly Glu Lys Pro Tyr
         195                 200                 205            
 Glu Cys Lys Glu Cys Gly Lys Ala Phe Arg Val Arg Gln Gln Leu Thr
     210                 215                 220                
 Leu His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu
 225                 230                 235                 240
 Cys Gly Lys Thr Phe Ser Arg Gly Tyr His Leu Ile Leu His His Arg
                 245                 250                 255    
 Ile His Thr Gly Xaa Lys Pro Tyr Glu Cys Lys Glu Cys Trp Lys Ala
             260                 265                 270        
 Phe Ser Arg Tyr Ser Gln Leu
         275                



      <210> 1765
      <211> 786
      <212> PRT
      <213> Homo sapiens


      <400> 1765
 Asp Ala Trp Gly Cys Lys Leu Arg Arg Leu Arg Phe Thr Tyr Gly Thr
   1               5                  10                  15    
 Gln Thr Arg Val Ser Leu Ala Leu Pro Gly Gln Tyr Glu Leu Val His
              20                  25                  30        
 Thr Leu Val Ala His Gln Gly Asn Trp Glu Thr Ile Pro Glu Glu Asp
          35                  40                  45            
 Leu Glu Val Gln Glu Asn Asn Glu Asp Ala Ala His Asp Leu Thr Glu
      50                  55                  60                
 Leu Glu Val Thr Met His His Ala Leu Leu Gln Glu Val Asp Val Val
  65                  70                  75                  80
 Val Ala Pro Cys Gln Gly Leu Arg Pro Thr Val Asp Val Leu Gly Asp
                  85                  90                  95    
 Leu Val Asn Asp Phe Leu Pro Val Ile Thr Tyr Ala Leu His Lys Asp
             100                 105                 110        
 Glu Leu Ser Glu Arg Asp Glu Gln Glu Leu Gln Glu Ile Arg Lys Tyr
         115                 120                 125            
 Phe Ser Phe Pro Val Phe Phe Phe Lys Val Pro Lys Leu Gly Ser Glu
     130                 135                 140                
 Ile Ile Asp Ser Ser Thr Arg Arg Met Glu Ser Glu Arg Ser Pro Leu
 145                 150                 155                 160
 Tyr Arg Gln Leu Ile Asp Leu Gly Tyr Leu Ser Ser Ser His Trp Asn
                 165                 170                 175    
 Cys Gly Ala Pro Gly Gln Asp Thr Lys Ala Gln Ser Met Leu Val Glu
             180                 185                 190        
 Gln Ser Glu Lys Leu Arg His Leu Ser Thr Phe Ser His Gln Val Leu
         195                 200                 205            
 Gln Thr Arg Leu Val Asp Ala Ala Lys Ala Leu Asn Leu Val His Cys
     210                 215                 220                
 His Cys Leu Asp Ile Phe Ile Asn Gln Ala Phe Asp Met Gln Arg Asp
 225                 230                 235                 240
 Leu Gln Ile Thr Pro Lys Arg Leu Glu Tyr Thr Arg Lys Lys Glu Asn
                 245                 250                 255    
 Glu Leu Tyr Glu Ser Leu Met Asn Ile Ala Asn Arg Lys Gln Glu Glu
             260                 265                 270        
 Met Lys Asp Met Ile Val Glu Thr Leu Asn Thr Met Lys Glu Glu Leu
         275                 280                 285            
 Leu Asp Asp Ala Thr Asn Met Glu Phe Lys Asp Val Ile Val Pro Glu
     290                 295                 300                
 Asn Gly Glu Pro Val Gly Thr Arg Glu Ile Lys Cys Cys Ile Arg Gln
 305                 310                 315                 320
 Ile Gln Glu Leu Ile Ile Ser Arg Leu Asn Gln Ala Val Ala Asn Lys
                 325                 330                 335    
 Leu Ile Ser Ser Val Asp Tyr Leu Arg Glu Ser Phe Val Gly Thr Leu
             340                 345                 350        
 Glu Arg Cys Leu Gln Ser Leu Glu Lys Ser Gln Asp Val Ser Val His
         355                 360                 365            
 Ile Thr Ser Asn Tyr Leu Lys Gln Ile Leu Asn Ala Ala Tyr His Val
     370                 375                 380                
 Glu Val Thr Phe His Ser Gly Ser Ser Val Thr Arg Met Leu Trp Glu
 385                 390                 395                 400
 Gln Ile Lys Gln Ile Ile Gln Arg Ile Thr Trp Val Ser Pro Pro Ala
                 405                 410                 415    
 Ile Thr Leu Glu Trp Lys Arg Lys Val Ala Gln Glu Ala Ile Glu Ser
             420                 425                 430        
 Leu Ser Ala Ser Lys Leu Ala Lys Ser Ile Cys Ser Gln Phe Arg Thr
         435                 440                 445            
 Arg Leu Asn Ser Ser His Glu Ala Phe Ala Ala Ser Leu Arg Gln Leu
     450                 455                 460                
 Glu Ala Gly His Ser Gly Arg Leu Glu Lys Thr Glu Asp Leu Trp Leu
 465                 470                 475                 480
 Arg Val Arg Lys Asp His Ala Pro Arg Leu Ala Arg Leu Ser Leu Glu
                 485                 490                 495    
 Ser Arg Ser Leu Gln Asp Val Leu Leu His Arg Lys Pro Lys Leu Gly
             500                 505                 510        
 Gln Glu Leu Gly Arg Gly Gln Tyr Gly Val Val Tyr Leu Cys Asp Asn
         515                 520                 525            
 Trp Gly Gly His Phe Pro Cys Ala Leu Lys Ser Val Val Pro Pro Asp
     530                 535                 540                
 Glu Lys His Trp Asn Asp Leu Ala Leu Glu Phe His Tyr Met Arg Ser
 545                 550                 555                 560
 Leu Pro Lys His Glu Arg Leu Val Asp Leu His Gly Ser Val Ile Asp
                 565                 570                 575    
 Tyr Asn Tyr Gly Gly Gly Ser Ser Ile Ala Val Leu Leu Ile Met Glu
             580                 585                 590        
 Arg Leu His Arg Asp Leu Tyr Thr Gly Leu Lys Ala Gly Leu Thr Leu
         595                 600                 605            
 Glu Thr Arg Leu Gln Ile Ala Leu Asp Val Val Glu Gly Ile Arg Phe
     610                 615                 620                
 Leu His Ser Gln Gly Leu Val His Arg Asp Ile Lys Leu Lys Asn Val
 625                 630                 635                 640
 Leu Leu Asp Lys Gln Asn Arg Ala Lys Ile Thr Asp Leu Gly Phe Cys
                 645                 650                 655    
 Lys Pro Glu Ala Met Met Ser Gly Ser Ile Val Gly Thr Pro Ile His
             660                 665                 670        
 Met Ala Pro Glu Leu Phe Thr Gly Lys Tyr Asp Asn Ser Val Asp Val
         675                 680                 685            
 Tyr Ala Phe Gly Ile Leu Phe Trp Tyr Ile Cys Ser Gly Ser Val Lys
     690                 695                 700                
 Leu Pro Glu Ala Phe Glu Arg Cys Ala Ser Lys Asp His Leu Trp Asn
 705                 710                 715                 720
 Asn Val Arg Arg Gly Ala Arg Pro Glu Arg Leu Pro Val Phe Asp Glu
                 725                 730                 735    
 Glu Cys Trp Gln Leu Met Glu Ala Cys Trp Asp Gly Asp Pro Leu Lys
             740                 745                 750        
 Arg Pro Leu Leu Gly Ile Val Gln Pro Met Leu Gln Gly Ile Met Asn
         755                 760                 765            
 Arg Leu Cys Lys Ser Asn Ser Glu Gln Pro Asn Arg Gly Leu Asp Asp
     770                 775                 780                
 Ser Thr
 785    



      <210> 1766
      <211> 614
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(614)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1766
 Tyr Ser Pro Arg Pro Arg Arg Arg Arg Lys Gly Arg Arg Ala Arg Arg
   1               5                  10                  15    
 Glu Val Gln Glu Gly Pro Ser Pro Trp Val His Gly Pro Arg Val Ala
              20                  25                  30        
 Glu Asp Thr Gly Leu Val Pro Asn Trp Leu Leu Leu Leu Pro Val Ala
          35                  40                  45            
 Ser Met Ala Glu Asp Trp Leu Asp Cys Pro Ala Leu Gly Pro Gly Trp
      50                  55                  60                
 Lys Arg Arg Glu Val Phe Arg Lys Ser Gly Ala Thr Cys Gly Arg Ser
  65                  70                  75                  80
 Asp Thr Tyr Tyr Gln Ser Pro Thr Gly Asp Arg Ile Arg Ser Lys Val
                  85                  90                  95    
 Glu Leu Thr Arg Tyr Leu Gly Pro Ala Cys Asp Leu Thr Leu Phe Asp
             100                 105                 110        
 Phe Lys Gln Gly Ile Leu Cys Tyr Pro Ala Pro Lys Ala His Pro Val
         115                 120                 125            
 Ala Val Ala Ser Lys Lys Arg Lys Lys Pro Ser Arg Pro Ala Lys Thr
     130                 135                 140                
 Arg Lys Arg Gln Val Gly Pro Gln Ser Gly Glu Val Arg Lys Glu Ala
 145                 150                 155                 160
 Pro Arg Asp Glu Thr Lys Ala Asp Thr Asp Thr Ala Pro Ala Ser Phe
                 165                 170                 175    
 Pro Ala Pro Gly Cys Cys Glu Asn Cys Gly Ile Ser Phe Ser Gly Asp
             180                 185                 190        
 Gly Thr Gln Arg Gln Arg Leu Lys Thr Leu Cys Lys Asp Cys Arg Ala
         195                 200                 205            
 Gln Arg Ile Ala Phe Asn Arg Glu Gln Arg Met Phe Lys Ser Arg Gly
     210                 215                 220                
 Cys Gly Val Cys Arg Gly Cys Gln Thr Gln Glu Asp Cys Gly His Cys
 225                 230                 235                 240
 Pro Ile Cys Leu Arg Pro Pro Arg Pro Gly Leu Arg Arg Gln Trp Lys
                 245                 250                 255    
 Cys Val Gln Arg Arg Cys Leu Arg Gly Lys His Ala Arg Arg Lys Gly
             260                 265                 270        
 Gly Cys Asp Ser Lys Met Ala Ala Arg Arg Arg Pro Gly Ala Gln Pro
         275                 280                 285            
 Leu Pro Pro Pro Pro Pro Ser Gln Ser Pro Glu Pro Thr Glu Pro His
     290                 295                 300                
 Pro Arg Ala Leu Ala Pro Ser Pro Pro Ala Glu Phe Ile Tyr Tyr Cys
 305                 310                 315                 320
 Val Asp Glu Asp Glu Leu Gln Pro Tyr Thr Asn Arg Arg Gln Asn Arg
                 325                 330                 335    
 Lys Cys Gly Ala Cys Ala Ala Cys Leu Arg Arg Asn Gly Cys Gly Arg
             340                 345                 350        
 Cys Asp Phe Cys Cys Asp Lys Pro Lys Phe Gly Gly Ser Asn Gln Lys
         355                 360                 365            
 Arg Gln Lys Cys Arg Trp Arg Gln Cys Leu Gln Phe Ala Met Lys Arg
     370                 375                 380                
 Leu Leu Pro Ser Val Trp Ser Glu Ser Glu Asp Gly Ala Gly Ser Pro
 385                 390                 395                 400
 Pro Pro Tyr Arg Arg Arg Lys Arg Pro Ser Ser Ala Arg Arg His His
                 405                 410                 415    
 Leu Gly Pro Thr Leu Lys Pro Thr Leu Ala Thr Arg Thr Ala Gln Pro
             420                 425                 430        
 Asp His Thr Gln Ala Pro Thr Lys Gln Glu Ala Gly Gly Gly Phe Val
         435                 440                 445            
 Leu Pro Pro Pro Gly His Xaa Thr Leu Cys Phe Leu Arg Glu Gly Ala
     450                 455                 460                
 Ser Ser Pro Val Gln Val Pro Gly Pro Val Ala Ala Ser Thr Glu Ala
 465                 470                 475                 480
 Leu Leu Gln Glu Ala Gln Cys Ser Gly Met Ser Trp Val Val Ala Leu
                 485                 490                 495    
 Pro Gln Val Lys Gln Glu Lys Ala Asp Thr Gln Asp Glu Trp Thr Pro
             500                 505                 510        
 Gly Thr Ala Val Leu Thr Ser Pro Val Leu Val Pro Gly Cys Pro Ser
         515                 520                 525            
 Lys Ala Val Asp Pro Gly Leu Pro Ser Val Lys Gln Glu Pro Pro Asp
     530                 535                 540                
 Pro Glu Glu Asp Lys Glu Glu Asn Lys Asp Asp Ser Ala Ser Lys Leu
 545                 550                 555                 560
 Ala Pro Glu Glu Glu Ala Gly Gly Ala Gly Thr Pro Val Ile Thr Glu
                 565                 570                 575    
 Ile Phe Ser Leu Gly Gly Thr Arg Phe Arg Asp Thr Ala Val Trp Leu
             580                 585                 590        
 Pro Arg Ser Lys Asp Leu Lys Lys Pro Gly Ala Arg Lys Gln Leu Thr
         595                 600                 605            
 Gly Gly Phe Tyr Arg Leu
     610                



      <210> 1767
      <211> 351
      <212> PRT
      <213> Homo sapiens


      <400> 1767
 Arg Ala Ser Ser Ala Val Arg Gly Ser Leu Gly Asp Ser Ala Arg Gly
   1               5                  10                  15    
 Arg Arg Arg Arg Ser Ile Val Lys Val Ser Leu His Pro Ala Val Met
              20                  25                  30        
 Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu Phe
          35                  40                  45            
 Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser His
      50                  55                  60                
 Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp Pro
  65                  70                  75                  80
 Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr Val
                  85                  90                  95    
 Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp Gly
             100                 105                 110        
 Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln Arg
         115                 120                 125            
 Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile Lys
     130                 135                 140                
 Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr Gly
 145                 150                 155                 160
 Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys Lys
                 165                 170                 175    
 Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp Lys
             180                 185                 190        
 Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu Val
         195                 200                 205            
 Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser Gln
     210                 215                 220                
 Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly Gly
 225                 230                 235                 240
 Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly Arg
                 245                 250                 255    
 Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser Gly
             260                 265                 270        
 Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly Gly
         275                 280                 285            
 Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn Phe
     290                 295                 300                
 Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro Tyr
 305                 310                 315                 320
 Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly Tyr
                 325                 330                 335    
 Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe
             340                 345                 350    



      <210> 1768
      <211> 230
      <212> PRT
      <213> Homo sapiens


      <400> 1768
 His Ile Val Phe Val Val His Gly Ile Gly Gln Lys Met Asp Gln Gly
   1               5                  10                  15    
 Arg Ile Ile Lys Asn Thr Ala Met Met Arg Glu Ala Ala Arg Lys Ile
              20                  25                  30        
 Glu Glu Arg His Phe Ser Asn His Ala Thr His Val Glu Phe Leu Pro
          35                  40                  45            
 Val Glu Trp Arg Ser Lys Leu Thr Leu Asp Gly Asp Thr Val Asp Ser
      50                  55                  60                
 Ile Thr Pro Asp Lys Val Arg Gly Leu Arg Asp Met Leu Asn Ser Ser
  65                  70                  75                  80
 Ala Met Asp Ile Met Tyr Tyr Thr Ser Pro Leu Tyr Arg Asp Glu Leu
                  85                  90                  95    
 Val Lys Gly Leu Gln Gln Glu Leu Asn Arg Leu Tyr Ser Leu Phe Cys
             100                 105                 110        
 Ser Arg Asn Pro Asp Phe Glu Glu Lys Gly Gly Lys Val Ser Ile Val
         115                 120                 125            
 Ser His Ser Leu Gly Cys Val Ile Thr Tyr Asp Ile Met Thr Gly Trp
     130                 135                 140                
 Asn Pro Val Arg Leu Tyr Glu Gln Leu Leu Gln Lys Glu Glu Glu Leu
 145                 150                 155                 160
 Pro Asp Glu Arg Trp Met Ser Tyr Glu Glu Arg His Leu Leu Asp Glu
                 165                 170                 175    
 Leu Tyr Ile Thr Lys Arg Arg Leu Lys Glu Ile Glu Glu Arg Leu His
             180                 185                 190        
 Gly Leu Lys Ala Ser Ser Met Thr Gln Thr Pro Ala Leu Lys Phe Lys
         195                 200                 205            
 Val Glu Asn Phe Phe Cys Met Gly Ser Pro Leu Ala Val Phe Phe Ala
     210                 215                 220                
 Leu Arg Gly Ile Arg Pro
 225                 230



      <210> 1769
      <211> 81
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(81)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1769
 Gly Lys Arg Phe Thr Arg Ser Asp Glu Leu Gln Arg His Arg Arg Ala
   1               5                  10                  15    
 His Thr Gly Glu Lys Lys Phe Val Cys Pro Glu Cys Ser Gln Arg Ser
              20                  25                  30        
 Met Arg Ser Asp Arg Leu Thr Gly His Ile Arg Ser His Gln Asn Lys
          35                  40                  45            
 Lys Gly Ile His Xaa Ser Gly Thr Val Pro Ser Arg Gly Ser Pro Trp
      50                  55                  60                
 Val Asp Gly Arg Leu Thr Thr Gln Leu Lys Lys Ala Glu Pro Gly Gly
  65                  70                  75                  80
 Phe
    



      <210> 1770
      <211> 414
      <212> PRT
      <213> Homo sapiens


      <400> 1770
 Ser Ser Lys Met Ser Lys Arg Pro Ser Tyr Ala Pro Pro Pro Thr Pro
   1               5                  10                  15    
 Ala Pro Ala Thr Gln Met Pro Ser Thr Pro Gly Phe Val Gly Tyr Asn
              20                  25                  30        
 Pro Tyr Ser His Leu Ala Tyr Asn Asn Tyr Arg Leu Gly Gly Asn Pro
          35                  40                  45            
 Gly Thr Asn Ser Arg Val Thr Ala Ser Ser Gly Ile Thr Ile Pro Lys
      50                  55                  60                
 Pro Pro Lys Pro Pro Asp Lys Pro Leu Met Pro Tyr Met Arg Tyr Ser
  65                  70                  75                  80
 Arg Lys Val Trp Asp Gln Val Lys Ala Ser Asn Pro Asp Leu Lys Leu
                  85                  90                  95    
 Trp Glu Ile Gly Lys Ile Ile Gly Gly Met Trp Arg Asp Leu Thr Asp
             100                 105                 110        
 Glu Glu Lys Gln Glu Tyr Leu Asn Glu Tyr Glu Ala Glu Lys Ile Glu
         115                 120                 125            
 Tyr Asn Glu Ser Met Lys Ala Tyr His Asn Ser Pro Ala Tyr Leu Ala
     130                 135                 140                
 Tyr Ile Asn Ala Lys Ser Arg Ala Glu Ala Ala Leu Glu Glu Glu Ser
 145                 150                 155                 160
 Arg Gln Arg Gln Ser Arg Met Glu Lys Gly Glu Pro Tyr Met Ser Ile
                 165                 170                 175    
 Gln Pro Ala Glu Asp Pro Asp Asp Tyr Asp Asp Gly Phe Ser Met Lys
             180                 185                 190        
 His Thr Ala Thr Ala Arg Phe Gln Arg Asn His Arg Leu Ile Ser Glu
         195                 200                 205            
 Ile Leu Ser Glu Ser Val Val Pro Asp Val Arg Ser Val Val Thr Thr
     210                 215                 220                
 Ala Arg Met Gln Val Leu Lys Arg Gln Val Gln Ser Leu Met Val His
 225                 230                 235                 240
 Gln Arg Lys Leu Glu Ala Glu Leu Leu Gln Ile Glu Glu Arg His Gln
                 245                 250                 255    
 Glu Lys Lys Arg Lys Phe Leu Glu Ser Thr Asp Ser Phe Asn Asn Glu
             260                 265                 270        
 Leu Lys Arg Leu Cys Gly Leu Lys Val Glu Val Asp Met Glu Lys Ile
         275                 280                 285            
 Ala Ala Glu Ile Ala Gln Ala Glu Glu Gln Ala Arg Lys Arg Gln Glu
     290                 295                 300                
 Glu Arg Glu Lys Glu Ala Ala Glu Gln Ala Glu Arg Ser Gln Ser Ser
 305                 310                 315                 320
 Ile Val Pro Glu Glu Glu Gln Ala Ala Asn Lys Gly Glu Glu Lys Lys
                 325                 330                 335    
 Asp Asp Glu Asn Ile Pro Met Glu Thr Glu Glu Thr His Leu Glu Glu
             340                 345                 350        
 Thr Thr Glu Ser Gln Gln Asn Gly Glu Glu Gly Thr Ser Thr Pro Glu
         355                 360                 365            
 Asp Lys Glu Ser Gly Gln Glu Gly Val Asp Ser Met Ala Glu Glu Gly
     370                 375                 380                
 Thr Ser Asp Ser Asn Thr Gly Ser Glu Ser Asn Ser Ala Thr Val Glu
 385                 390                 395                 400
 Glu Pro Pro Thr Asp Pro Ile Pro Glu Asp Glu Lys Lys Glu
                 405                 410                



      <210> 1771
      <211> 381
      <212> PRT
      <213> Homo sapiens


      <400> 1771
 Lys Asp Ser Val Leu Asn Ile Ala Arg Gly Lys Lys Tyr Gly Glu Lys
   1               5                  10                  15    
 Thr Lys Arg Val Ser Ser Arg Lys Lys Pro Ala Leu Lys Cys Thr Ser
              20                  25                  30        
 Gln Lys Gln Pro Ala Leu Lys Ala Ile Cys Asp Lys Glu Asp Ser Val
          35                  40                  45            
 Pro Asn Thr Ala Thr Glu Lys Lys Asp Glu Gln Ile Ser Gly Thr Val
      50                  55                  60                
 Ser Ser Gln Lys Gln Pro Ala Leu Lys Ala Thr Ser Asp Lys Lys Asp
  65                  70                  75                  80
 Ser Val Ser Asn Ile Pro Thr Glu Ile Lys Asp Gly Gln Gln Ser Gly
                  85                  90                  95    
 Thr Val Ser Ser Gln Lys Gln Pro Ala Trp Lys Ala Thr Ser Val Lys
             100                 105                 110        
 Lys Asp Ser Val Ser Asn Ile Ala Thr Glu Ile Lys Asp Gly Gln Ile
         115                 120                 125            
 Arg Gly Thr Val Ser Ser Gln Arg Gln Pro Ala Leu Lys Ala Thr Gly
     130                 135                 140                
 Asp Glu Lys Asp Ser Val Ser Asn Ile Ala Arg Glu Ile Lys Asp Gly
 145                 150                 155                 160
 Glu Lys Ser Gly Thr Val Ser Pro Gln Lys Gln Ser Ala Gln Lys Val
                 165                 170                 175    
 Ile Phe Lys Lys Lys Val Ser Leu Leu Asn Ile Ala Thr Arg Ile Thr
             180                 185                 190        
 Gly Gly Trp Lys Ser Gly Thr Glu Tyr Pro Glu Asn Leu Pro Thr Leu
         195                 200                 205            
 Lys Ala Thr Ile Glu Asn Lys Asn Ser Val Leu Asn Thr Ala Thr Lys
     210                 215                 220                
 Met Lys Asp Val Gln Thr Ser Thr Pro Glu Gln Asp Leu Glu Met Ala
 225                 230                 235                 240
 Ser Glu Gly Glu Gln Lys Arg Leu Glu Glu Tyr Glu Asn Asn Gln Pro
                 245                 250                 255    
 Gln Val Lys Asn Gln Ile His Ser Arg Asp Asp Leu Asp Asp Ile Ile
             260                 265                 270        
 Gln Ser Ser Gln Thr Val Ser Glu Asp Gly Asp Ser Leu Cys Cys Asn
         275                 280                 285            
 Cys Lys Asn Val Ile Leu Leu Ile Asp Gln His Glu Met Lys Cys Lys
     290                 295                 300                
 Asp Cys Val His Leu Leu Lys Ile Lys Lys Thr Phe Cys Leu Cys Lys
 305                 310                 315                 320
 Arg Leu Thr Glu Leu Lys Asp Asn His Cys Glu Gln Leu Arg Val Lys
                 325                 330                 335    
 Ile Arg Lys Leu Lys Asn Lys Ala Ser Val Leu Gln Lys Arg Leu Ser
             340                 345                 350        
 Glu Lys Glu Glu Ile Lys Ser Gln Leu Lys His Glu Thr Leu Glu Leu
         355                 360                 365            
 Glu Lys Glu Leu Cys Ser Leu Arg Phe Ala Ile Gln Gln
     370                 375                 380    



      <210> 1772
      <211> 381
      <212> PRT
      <213> Homo sapiens


      <400> 1772
 Lys Asp Ser Val Leu Asn Ile Ala Arg Gly Lys Lys Tyr Gly Glu Lys
   1               5                  10                  15    
 Thr Lys Arg Val Ser Ser Arg Lys Lys Pro Ala Leu Lys Cys Thr Ser
              20                  25                  30        
 Gln Lys Gln Pro Ala Leu Lys Ala Ile Cys Asp Lys Glu Asp Ser Val
          35                  40                  45            
 Pro Asn Thr Ala Thr Glu Lys Lys Asp Glu Gln Ile Ser Gly Thr Val
      50                  55                  60                
 Ser Ser Gln Lys Gln Pro Ala Leu Lys Ala Thr Ser Asp Lys Lys Asp
  65                  70                  75                  80
 Ser Val Ser Asn Ile Pro Thr Glu Ile Lys Asp Gly Gln Gln Ser Gly
                  85                  90                  95    
 Thr Val Ser Ser Gln Lys Gln Pro Ala Trp Lys Ala Thr Ser Val Lys
             100                 105                 110        
 Lys Asp Ser Val Ser Asn Ile Ala Thr Glu Ile Lys Asp Gly Gln Ile
         115                 120                 125            
 Arg Gly Thr Val Ser Ser Gln Arg Gln Pro Ala Leu Lys Ala Thr Gly
     130                 135                 140                
 Asp Glu Lys Asp Ser Val Ser Asn Ile Ala Arg Glu Ile Lys Asp Gly
 145                 150                 155                 160
 Glu Lys Ser Gly Thr Val Ser Pro Gln Lys Gln Ser Ala Gln Lys Val
                 165                 170                 175    
 Ile Phe Lys Lys Lys Val Ser Leu Leu Asn Ile Ala Thr Arg Ile Thr
             180                 185                 190        
 Gly Gly Trp Lys Ser Gly Thr Glu Tyr Pro Glu Asn Leu Pro Thr Leu
         195                 200                 205            
 Lys Ala Thr Ile Glu Asn Lys Asn Ser Val Leu Asn Thr Ala Thr Lys
     210                 215                 220                
 Met Lys Asp Val Gln Thr Ser Thr Pro Glu Gln Asp Leu Glu Met Ala
 225                 230                 235                 240
 Ser Glu Gly Glu Gln Lys Arg Leu Glu Glu Tyr Glu Asn Asn Gln Pro
                 245                 250                 255    
 Gln Val Lys Asn Gln Ile His Ser Arg Asp Asp Leu Asp Asp Ile Ile
             260                 265                 270        
 Gln Ser Ser Gln Thr Val Ser Glu Asp Gly Asp Ser Leu Cys Cys Asn
         275                 280                 285            
 Cys Lys Asn Val Ile Leu Leu Ile Asp Gln His Glu Met Lys Cys Lys
     290                 295                 300                
 Asp Cys Val His Leu Leu Lys Ile Lys Lys Thr Phe Cys Leu Cys Lys
 305                 310                 315                 320
 Arg Leu Thr Glu Leu Lys Asp Asn His Cys Glu Gln Leu Arg Val Lys
                 325                 330                 335    
 Ile Arg Lys Leu Lys Asn Lys Ala Ser Val Leu Gln Lys Arg Leu Ser
             340                 345                 350        
 Glu Lys Glu Glu Ile Lys Ser Gln Leu Lys His Glu Thr Leu Glu Leu
         355                 360                 365            
 Glu Lys Glu Leu Cys Ser Leu Arg Phe Ala Ile Gln Gln
     370                 375                 380    



      <210> 1773
      <211> 92
      <212> PRT
      <213> Homo sapiens


      <400> 1773
 Asn Thr Arg Val Ala Asn Asp Glu Arg Cys Arg Val Leu Ile Ser Ser
   1               5                  10                  15    
 Leu Lys Asp Cys Leu His Gly Ile Glu Ala Lys Ser Tyr Ser Val Gly
              20                  25                  30        
 Ala Ser Gly Ser Ser Ser Arg Lys Arg His Arg Ser Arg Glu Arg Ser
          35                  40                  45            
 Pro Ser Arg Ser Arg Glu Ser Ser Arg Arg His Arg Asp Leu Leu His
      50                  55                  60                
 Asn Glu Asp Arg His Asp Asp Tyr Phe Gln Glu Arg Asn Arg Glu His
  65                  70                  75                  80
 Glu Arg His Arg Asp Arg Glu Arg Asp Arg His His
                  85                  90        



      <210> 1774
      <211> 240
      <212> PRT
      <213> Homo sapiens


      <400> 1774
 Gly Thr Arg Phe Asp Val Glu Phe Val Asp Glu Gly Ser Thr Ser Met
   1               5                  10                  15    
 Asp Leu Phe Glu Ala Trp Lys Lys Glu Tyr Lys Leu Leu His Glu Tyr
              20                  25                  30        
 Trp Met Ala Leu Arg Asn Arg Val Ser Ala Val Asp Glu Leu Ala Met
          35                  40                  45            
 Ala Thr Glu Arg Leu Arg Val Arg Asp Pro Arg Glu Pro Lys Pro Asn
      50                  55                  60                
 Pro Pro Val Leu His Ile Ile Glu Pro His Glu Val Glu Gln Asn Arg
  65                  70                  75                  80
 Ile Lys Leu Leu Asn Asp Lys Ala Val Ala Thr Ser Gln Leu Gln Lys
                  85                  90                  95    
 Lys Leu Gly Gln Leu Leu Tyr Leu Thr Asn Leu Glu Lys Ser Gln Asp
             100                 105                 110        
 Lys Thr Ser Gly Gly Val Asn Pro Glu Pro Cys Pro Ile Cys Ala Arg
         115                 120                 125            
 Gln Leu Gly Lys Gln Trp Ala Val Leu Thr Cys Gly His Cys Phe Cys
     130                 135                 140                
 Asn Glu Cys Ile Ser Ile Ile Ile Glu Gln Tyr Ser Val Gly Ser His
 145                 150                 155                 160
 Arg Ser Ser Ile Lys Cys Ala Ile Cys Arg Gln Thr Thr Ser His Lys
                 165                 170                 175    
 Glu Ile Ser Tyr Val Phe Thr Ser Glu Lys Ala Asn Gln Glu Glu Asp
             180                 185                 190        
 Ile Pro Val Lys Gly Ser His Ser Thr Lys Val Glu Ala Val Val Arg
         195                 200                 205            
 Thr Leu Met Lys Ile Gln Leu Arg Asp Pro Gly Ala Lys Ala Leu Val
     210                 215                 220                
 Phe Ser Thr Trp Gln Asp Val Leu Asp Ile Ile Ser Lys Ala Leu Thr
 225                 230                 235                 240





      <210> 1775
      <211> 1023
      <212> PRT
      <213> Homo sapiens


      <400> 1775
 Leu Asp Glu Tyr Glu Ala Arg Leu Thr Leu Ala Asn Leu Asp Asp Phe
   1               5                  10                  15    
 Glu Glu Asp Asn Glu Asp Asp Asp Glu Asn Arg Val Asn Gln Glu Glu
              20                  25                  30        
 Lys Ala Ala Lys Ile Thr Glu Leu Ile Asn Lys Leu Asn Phe Leu Asp
          35                  40                  45            
 Glu Ala Glu Lys Asp Leu Ala Thr Val Asn Ser Asn Pro Phe Asp Asp
      50                  55                  60                
 Pro Asp Ala Ala Glu Leu Asn Pro Phe Gly Asp Pro Asp Ser Glu Glu
  65                  70                  75                  80
 Pro Ile Thr Glu Thr Ala Ser Pro Arg Lys Thr Glu Asp Ser Phe Tyr
                  85                  90                  95    
 Asn Asn Ser Tyr Asn Pro Phe Lys Glu Val Gln Thr Pro Gln Tyr Leu
             100                 105                 110        
 Asn Pro Phe Asp Glu Pro Glu Ala Phe Val Thr Ile Lys Asp Ser Pro
         115                 120                 125            
 Pro Gln Ser Thr Lys Lys Lys Asn Ile Arg Pro Val Asp Met Ser Lys
     130                 135                 140                
 Tyr Leu Tyr Ala Asp Ser Ser Lys Thr Glu Glu Glu Glu Leu Asp Glu
 145                 150                 155                 160
 Ser Asn Pro Phe Tyr Glu Pro Lys Ser Thr Pro Pro Pro Asn Asn Leu
                 165                 170                 175    
 Val Asn Pro Val Gln Glu Leu Glu Thr Glu Arg Arg Val Lys Arg Lys
             180                 185                 190        
 Ala Pro Ala Pro Pro Val Leu Ser Pro Lys Thr Gly Val Leu Asn Glu
         195                 200                 205            
 Asn Thr Val Ser Ala Gly Lys Asp Leu Ser Thr Ser Pro Lys Pro Ser
     210                 215                 220                
 Pro Ile Pro Ser Pro Val Leu Gly Arg Lys Pro Asn Ala Ser Gln Ser
 225                 230                 235                 240
 Leu Leu Val Trp Cys Lys Glu Val Thr Lys Asn Tyr Arg Gly Val Lys
                 245                 250                 255    
 Ile Thr Asn Phe Thr Thr Ser Trp Arg Asn Gly Leu Ser Phe Cys Ala
             260                 265                 270        
 Ile Leu His His Phe Arg Pro Asp Leu Ile Asp Tyr Lys Ser Leu Asn
         275                 280                 285            
 Pro Gln Asp Ile Lys Glu Asn Asn Lys Lys Ala Tyr Asp Gly Phe Ala
     290                 295                 300                
 Ser Ile Gly Ile Ser Arg Leu Leu Glu Pro Ser Asp Met Val Leu Leu
 305                 310                 315                 320
 Ala Ile Pro Asp Lys Leu Thr Val Met Thr Tyr Leu Tyr Gln Ile Arg
                 325                 330                 335    
 Ala His Phe Ser Gly Gln Glu Leu Asn Val Val Gln Ile Glu Glu Asn
             340                 345                 350        
 Ser Ser Lys Ser Thr Tyr Lys Val Gly Asn Tyr Glu Thr Asp Thr Asn
         355                 360                 365            
 Ser Ser Val Asp Gln Glu Lys Phe Tyr Ala Glu Leu Ser Asp Leu Lys
     370                 375                 380                
 Arg Glu Pro Glu Leu Gln Gln Pro Ile Ser Gly Ala Val Asp Phe Leu
 385                 390                 395                 400
 Ser Gln Asp Asp Ser Val Phe Val Asn Asp Ser Gly Val Gly Glu Ser
                 405                 410                 415    
 Glu Ser Glu His Gln Thr Pro Asp Asp His Leu Ser Pro Ser Thr Ala
             420                 425                 430        
 Ser Pro Tyr Cys Arg Arg Thr Lys Ser Asp Thr Glu Pro Gln Lys Ser
         435                 440                 445            
 Gln Gln Ser Ser Gly Arg Thr Ser Gly Ser Asp Asp Pro Gly Ile Cys
     450                 455                 460                
 Ser Asn Thr Asp Ser Thr Gln Ala Gln Val Leu Leu Gly Lys Lys Arg
 465                 470                 475                 480
 Leu Leu Lys Ala Glu Thr Leu Glu Leu Ser Asp Leu Tyr Val Ser Asp
                 485                 490                 495    
 Lys Lys Lys Asp Met Ser Pro Pro Phe Ile Cys Glu Glu Thr Asp Glu
             500                 505                 510        
 Gln Lys Leu Gln Thr Leu Asp Ile Gly Ser Asn Leu Glu Lys Glu Lys
         515                 520                 525            
 Leu Glu Asn Ser Arg Ser Leu Glu Cys Arg Ser Asp Pro Glu Ser Pro
     530                 535                 540                
 Ile Lys Lys Thr Ser Leu Ser Pro Thr Ser Lys Leu Gly Tyr Ser Tyr
 545                 550                 555                 560
 Ser Arg Asp Leu Asp Leu Ala Lys Lys Lys His Ala Ser Leu Arg Gln
                 565                 570                 575    
 Thr Glu Ser Asp Pro Asp Ala Asp Arg Thr Thr Leu Asn His Ala Asp
             580                 585                 590        
 His Ser Ser Lys Ile Val Gln His Arg Leu Leu Ser Arg Gln Glu Glu
         595                 600                 605            
 Leu Lys Glu Arg Ala Arg Val Leu Leu Glu Gln Ala Arg Arg Asp Ala
     610                 615                 620                
 Ala Leu Lys Ala Gly Asn Lys His Asn Thr Asn Thr Ala Ala Pro Phe
 625                 630                 635                 640
 Cys Asn Arg Gln Leu Ser Asp Gln Gln Asp Glu Glu Arg Arg Arg Gln
                 645                 650                 655    
 Leu Arg Glu Arg Ala Arg Gln Leu Ile Ala Glu Ala Arg Ser Gly Gly
             660                 665                 670        
 Lys Met Ser Glu Leu Pro Ser Tyr Gly Glu Arg Ala Ala Glu Lys Leu
         675                 680                 685            
 Lys Glu Arg Ser Lys Ala Ser Gly Asp Glu Asn Asp Asn Ile Glu Ile
     690                 695                 700                
 Asp Thr Asn Glu Glu Ile Pro Glu Gly Phe Val Val Gly Gly Gly Asp
 705                 710                 715                 720
 Glu Leu Thr Asn Leu Glu Asn Asp Leu Asp Thr Pro Glu Gln Asn Ser
                 725                 730                 735    
 Lys Leu Val Asp Leu Lys Leu Lys Lys Leu Leu Glu Val Gln Pro Gln
             740                 745                 750        
 Val Ala Asn Ser Pro Ser Ser Ala Ala Gln Lys Ala Val Thr Glu Ser
         755                 760                 765            
 Ser Glu Gln Asp Met Lys Ser Gly Thr Glu Asp Leu Arg Thr Glu Arg
     770                 775                 780                
 Leu Gln Lys Thr Thr Glu Arg Phe Arg Asn Pro Val Val Phe Ser Lys
 785                 790                 795                 800
 Asp Ser Thr Val Arg Lys Thr Gln Leu Gln Ser Phe Ser Gln Tyr Ile
                 805                 810                 815    
 Glu Asn Arg Pro Glu Met Lys Arg Gln Arg Ser Ile Gln Glu Asp Thr
             820                 825                 830        
 Lys Lys Gly Asn Glu Glu Lys Ala Ala Ile Thr Glu Thr Gln Arg Lys
         835                 840                 845            
 Pro Ser Glu Asp Glu Val Leu Asn Lys Gly Phe Lys Asp Ser Ser Gln
     850                 855                 860                
 Tyr Val Val Gly Glu Leu Ala Ala Leu Glu Asn Glu Gln Lys Gln Ile
 865                 870                 875                 880
 Asp Thr Arg Ala Ala Leu Val Glu Lys Arg Leu Arg Tyr Leu Met Asp
                 885                 890                 895    
 Thr Gly Arg Asn Thr Glu Glu Glu Glu Ala Met Met Gln Glu Trp Phe
             900                 905                 910        
 Met Leu Val Asn Lys Lys Asn Ala Leu Ile Arg Arg Met Asn Gln Leu
         915                 920                 925            
 Ser Leu Leu Glu Lys Glu His Asp Leu Glu Arg Arg Tyr Glu Leu Leu
     930                 935                 940                
 Asn Arg Glu Leu Arg Ala Met Leu Ala Ile Glu Asp Trp Gln Lys Thr
 945                 950                 955                 960
 Glu Ala Gln Lys Arg Arg Glu Gln Leu Leu Leu Asp Glu Leu Val Ala
                 965                 970                 975    
 Leu Val Asn Lys Arg Asp Ala Leu Val Arg Asp Leu Asp Ala Gln Glu
             980                 985                 990        
 Lys Gln Ala Glu Glu Glu Asp Glu His Leu Glu Arg Thr Leu Glu Gln
         995                1000                1005            
 Asn Lys Gly Lys Met Ala Lys Lys Glu Glu Lys Cys Val Leu Gln
    1010                1015                1020            



      <210> 1776
      <211> 1023
      <212> PRT
      <213> Homo sapiens


      <400> 1776
 Leu Asp Glu Tyr Glu Ala Arg Leu Thr Leu Ala Asn Leu Asp Asp Phe
   1               5                  10                  15    
 Glu Glu Asp Asn Glu Asp Asp Asp Glu Asn Arg Val Asn Gln Glu Glu
              20                  25                  30        
 Lys Ala Ala Lys Ile Thr Glu Leu Ile Asn Lys Leu Asn Phe Leu Asp
          35                  40                  45            
 Glu Ala Glu Lys Asp Leu Ala Thr Val Asn Ser Asn Pro Phe Asp Asp
      50                  55                  60                
 Pro Asp Ala Ala Glu Leu Asn Pro Phe Gly Asp Pro Asp Ser Glu Glu
  65                  70                  75                  80
 Pro Ile Thr Glu Thr Ala Ser Pro Arg Lys Thr Glu Asp Ser Phe Tyr
                  85                  90                  95    
 Asn Asn Ser Tyr Asn Pro Phe Lys Glu Val Gln Thr Pro Gln Tyr Leu
             100                 105                 110        
 Asn Pro Phe Asp Glu Pro Glu Ala Phe Val Thr Ile Lys Asp Ser Pro
         115                 120                 125            
 Pro Gln Ser Thr Lys Lys Lys Asn Ile Arg Pro Val Asp Met Ser Lys
     130                 135                 140                
 Tyr Leu Tyr Ala Asp Ser Ser Lys Thr Glu Glu Glu Glu Leu Asp Glu
 145                 150                 155                 160
 Ser Asn Pro Phe Tyr Glu Pro Lys Ser Thr Pro Pro Pro Asn Asn Leu
                 165                 170                 175    
 Val Asn Pro Val Gln Glu Leu Glu Thr Glu Arg Arg Val Lys Arg Lys
             180                 185                 190        
 Ala Pro Ala Pro Pro Val Leu Ser Pro Lys Thr Gly Val Leu Asn Glu
         195                 200                 205            
 Asn Thr Val Ser Ala Gly Lys Asp Leu Ser Thr Ser Pro Lys Pro Ser
     210                 215                 220                
 Pro Ile Pro Ser Pro Val Leu Gly Arg Lys Pro Asn Ala Ser Gln Ser
 225                 230                 235                 240
 Leu Leu Val Trp Cys Lys Glu Val Thr Lys Asn Tyr Arg Gly Val Lys
                 245                 250                 255    
 Ile Thr Asn Phe Thr Thr Ser Trp Arg Asn Gly Leu Ser Phe Cys Ala
             260                 265                 270        
 Ile Leu His His Phe Arg Pro Asp Leu Ile Asp Tyr Lys Ser Leu Asn
         275                 280                 285            
 Pro Gln Asp Ile Lys Glu Asn Asn Lys Lys Ala Tyr Asp Gly Phe Ala
     290                 295                 300                
 Ser Ile Gly Ile Ser Arg Leu Leu Glu Pro Ser Asp Met Val Leu Leu
 305                 310                 315                 320
 Ala Ile Pro Asp Lys Leu Thr Val Met Thr Tyr Leu Tyr Gln Ile Arg
                 325                 330                 335    
 Ala His Phe Ser Gly Gln Glu Leu Asn Val Val Gln Ile Glu Glu Asn
             340                 345                 350        
 Ser Ser Lys Ser Thr Tyr Lys Val Gly Asn Tyr Glu Thr Asp Thr Asn
         355                 360                 365            
 Ser Ser Val Asp Gln Glu Lys Phe Tyr Ala Glu Leu Ser Asp Leu Lys
     370                 375                 380                
 Arg Glu Pro Glu Leu Gln Gln Pro Ile Ser Gly Ala Val Asp Phe Leu
 385                 390                 395                 400
 Ser Gln Asp Asp Ser Val Phe Val Asn Asp Ser Gly Val Gly Glu Ser
                 405                 410                 415    
 Glu Ser Glu His Gln Thr Pro Asp Asp His Leu Ser Pro Ser Thr Ala
             420                 425                 430        
 Ser Pro Tyr Cys Arg Arg Thr Lys Ser Asp Thr Glu Pro Gln Lys Ser
         435                 440                 445            
 Gln Gln Ser Ser Gly Arg Thr Ser Gly Ser Asp Asp Pro Gly Ile Cys
     450                 455                 460                
 Ser Asn Thr Asp Ser Thr Gln Ala Gln Val Leu Leu Gly Lys Lys Arg
 465                 470                 475                 480
 Leu Leu Lys Ala Glu Thr Leu Glu Leu Ser Asp Leu Tyr Val Ser Asp
                 485                 490                 495    
 Lys Lys Lys Asp Met Ser Pro Pro Phe Ile Cys Glu Glu Thr Asp Glu
             500                 505                 510        
 Gln Lys Leu Gln Thr Leu Asp Ile Gly Ser Asn Leu Glu Lys Glu Lys
         515                 520                 525            
 Leu Glu Asn Ser Arg Ser Leu Glu Cys Arg Ser Asp Pro Glu Ser Pro
     530                 535                 540                
 Ile Lys Lys Thr Ser Leu Ser Pro Thr Ser Lys Leu Gly Tyr Ser Tyr
 545                 550                 555                 560
 Ser Arg Asp Leu Asp Leu Ala Lys Lys Lys His Ala Ser Leu Arg Gln
                 565                 570                 575    
 Thr Glu Ser Asp Pro Asp Ala Asp Arg Thr Thr Leu Asn His Ala Asp
             580                 585                 590        
 His Ser Ser Lys Ile Val Gln His Arg Leu Leu Ser Arg Gln Glu Glu
         595                 600                 605            
 Leu Lys Glu Arg Ala Arg Val Leu Leu Glu Gln Ala Arg Arg Asp Ala
     610                 615                 620                
 Ala Leu Lys Ala Gly Asn Lys His Asn Thr Asn Thr Ala Ala Pro Phe
 625                 630                 635                 640
 Cys Asn Arg Gln Leu Ser Asp Gln Gln Asp Glu Glu Arg Arg Arg Gln
                 645                 650                 655    
 Leu Arg Glu Arg Ala Arg Gln Leu Ile Ala Glu Ala Arg Ser Gly Gly
             660                 665                 670        
 Lys Met Ser Glu Leu Pro Ser Tyr Gly Glu Arg Ala Ala Glu Lys Leu
         675                 680                 685            
 Lys Glu Arg Ser Lys Ala Ser Gly Asp Glu Asn Asp Asn Ile Glu Ile
     690                 695                 700                
 Asp Thr Asn Glu Glu Ile Pro Glu Gly Phe Val Val Gly Gly Gly Asp
 705                 710                 715                 720
 Glu Leu Thr Asn Leu Glu Asn Asp Leu Asp Thr Pro Glu Gln Asn Ser
                 725                 730                 735    
 Lys Leu Val Asp Leu Lys Leu Lys Lys Leu Leu Glu Val Gln Pro Gln
             740                 745                 750        
 Val Ala Asn Ser Pro Ser Ser Ala Ala Gln Lys Ala Val Thr Glu Ser
         755                 760                 765            
 Ser Glu Gln Asp Met Lys Ser Gly Thr Glu Asp Leu Arg Thr Glu Arg
     770                 775                 780                
 Leu Gln Lys Thr Thr Glu Arg Phe Arg Asn Pro Val Val Phe Ser Lys
 785                 790                 795                 800
 Asp Ser Thr Val Arg Lys Thr Gln Leu Gln Ser Phe Ser Gln Tyr Ile
                 805                 810                 815    
 Glu Asn Arg Pro Glu Met Lys Arg Gln Arg Ser Ile Gln Glu Asp Thr
             820                 825                 830        
 Lys Lys Gly Asn Glu Glu Lys Ala Ala Ile Thr Glu Thr Gln Arg Lys
         835                 840                 845            
 Pro Ser Glu Asp Glu Val Leu Asn Lys Gly Phe Lys Asp Ser Ser Gln
     850                 855                 860                
 Tyr Val Val Gly Glu Leu Ala Ala Leu Glu Asn Glu Gln Lys Gln Ile
 865                 870                 875                 880
 Asp Thr Arg Ala Ala Leu Val Glu Lys Arg Leu Arg Tyr Leu Met Asp
                 885                 890                 895    
 Thr Gly Arg Asn Thr Glu Glu Glu Glu Ala Met Met Gln Glu Trp Phe
             900                 905                 910        
 Met Leu Val Asn Lys Lys Asn Ala Leu Ile Arg Arg Met Asn Gln Leu
         915                 920                 925            
 Ser Leu Leu Glu Lys Glu His Asp Leu Glu Arg Arg Tyr Glu Leu Leu
     930                 935                 940                
 Asn Arg Glu Leu Arg Ala Met Leu Ala Ile Glu Asp Trp Gln Lys Thr
 945                 950                 955                 960
 Glu Ala Gln Lys Arg Arg Glu Gln Leu Leu Leu Asp Glu Leu Val Ala
                 965                 970                 975    
 Leu Val Asn Lys Arg Asp Ala Leu Val Arg Asp Leu Asp Ala Gln Glu
             980                 985                 990        
 Lys Gln Ala Glu Glu Glu Asp Glu His Leu Glu Arg Thr Leu Glu Gln
         995                1000                1005            
 Asn Lys Gly Lys Met Ala Lys Lys Glu Glu Lys Cys Val Leu Gln
    1010                1015                1020            



      <210> 1777
      <211> 221
      <212> PRT
      <213> Homo sapiens


      <400> 1777
 Ala Ala Ser Thr Lys Asp Ala Val Ser Arg Lys Arg Ser His Ser Ala
   1               5                  10                  15    
 Ser Glu Lys Ser Gly Thr Gly Thr Ser Ile Ser Lys Arg Leu Asn Met
              20                  25                  30        
 Asn Pro Gln Ile Arg Asn Pro Met Lys Ala Met Tyr Pro Gly Thr Phe
          35                  40                  45            
 Tyr Phe Gln Phe Lys Asn Leu Trp Glu Ala Asn Asp Arg Asn Glu Thr
      50                  55                  60                
 Trp Leu Cys Phe Thr Val Glu Gly Ile Lys Arg Arg Ser Val Val Ser
  65                  70                  75                  80
 Trp Lys Thr Gly Val Phe Arg Asn Gln Val Asp Ser Glu Thr His Cys
                  85                  90                  95    
 His Ala Glu Arg Cys Phe Leu Ser Trp Phe Cys Asp Asp Ile Leu Ser
             100                 105                 110        
 Pro Asn Thr Lys Tyr Gln Val Thr Trp Tyr Thr Ser Trp Ser Pro Cys
         115                 120                 125            
 Pro Asp Cys Ala Gly Glu Val Ala Glu Phe Leu Ala Arg His Ser Asn
     130                 135                 140                
 Val Asn Leu Thr Ile Phe Thr Ala Arg Leu Tyr Tyr Phe Gln Tyr Pro
 145                 150                 155                 160
 Cys Tyr Gln Glu Gly Leu Arg Ser Leu Ser Gln Glu Gly Val Ala Val
                 165                 170                 175    
 Glu Ile Met Asp Tyr Glu Asp Phe Lys Tyr Cys Trp Glu Asn Phe Val
             180                 185                 190        
 Tyr Asn Asp Asn Glu Pro Phe Lys Pro Trp Lys Gly Leu Lys Thr Asn
         195                 200                 205            
 Phe Arg Leu Leu Lys Arg Arg Leu Arg Glu Ser Leu Gln
     210                 215                 220    



      <210> 1778
      <211> 158
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(158)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1778
 Val Val Leu Val Ser Arg Arg Ala Gln Ala Ala Val Glu His Leu Ser
   1               5                  10                  15    
 Ala Gly Val Gly Gln Val Arg Phe Gly Gly Lys Ala Cys Ala Ala Val
              20                  25                  30        
 His Arg Trp Phe Gly Gln Gly Gln Pro Gln Lys Val Ala Gln Glu Arg
          35                  40                  45            
 Val Cys Gly Val Gln Ala Xaa Pro Ala Met Phe Ala Asp Gly Leu Pro
      50                  55                  60                
 Leu Gly Val Asn Leu Gly Lys Asn Lys Thr Ser Val Asp Ala Ala Glu
  65                  70                  75                  80
 Asp Tyr Ala Glu Gly Val Arg Val Leu Gly Pro Leu Ala Asp Tyr Leu
                  85                  90                  95    
 Val Val Asn Val Ser Ser Pro Asn Thr Ala Gly Leu Arg Ser Leu Gln
             100                 105                 110        
 Gly Lys Ala Glu Leu Arg Arg Leu Leu Thr Lys Val Gly Ser Cys Thr
         115                 120                 125            
 Pro Leu Gln Ala Leu Ser His Gln Pro Val Pro Pro Ala Pro Leu His
     130                 135                 140                
 Ser Pro Gly Arg Thr Phe Ser Ile Thr Leu Arg Ser Cys Pro
 145                 150                 155            



      <210> 1779
      <211> 92
      <212> PRT
      <213> Homo sapiens


      <400> 1779
 Gln Ser Arg Lys Pro Tyr Thr Gln Arg Ser Arg Gln Ile Thr Glu Thr
   1               5                  10                  15    
 Ser Arg Asn Leu Cys Gly Asp Ser Gly Arg Gly Lys Arg Arg Arg Gly
              20                  25                  30        
 Ile Arg Ile Tyr Gly Asp Val Pro Ala Ser His Asp Ser Glu Leu Met
          35                  40                  45            
 Ala Phe Met Thr Arg Lys Leu Trp Asp Leu Glu Gln Gln Val Lys Ala
      50                  55                  60                
 Gln Thr Asp Glu Ile Leu Ser Lys Asp Gln Lys Ile Ala Ala Leu Glu
  65                  70                  75                  80
 Asp Leu Val Gln Thr Leu Arg Pro His Pro Ala Glu
                  85                  90        



      <210> 1780
      <211> 77
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(77)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1780
 Trp Pro Arg Asn Gln Pro Thr Arg Arg Pro Trp Leu Lys Asp Lys Leu
   1               5                  10                  15    
 Pro Gly Val Pro Gly Gly Leu Thr Gly Pro Asn Pro Cys Gly Gln Gly
              20                  25                  30        
 Pro Pro Gly Pro Pro Pro Pro Leu Arg Pro Ser Ala Leu Trp Ser Ser
          35                  40                  45            
 His Ser Gly Pro Pro Pro Asn Gly Glu Pro Leu Pro Pro Arg Gly Glu
      50                  55                  60                
 Xaa Tyr Leu His Pro Ser Pro Arg Arg Thr Ser Tyr Leu
  65                  70                  75        



      <210> 1781
      <211> 227
      <212> PRT
      <213> Homo sapiens


      <400> 1781
 Arg Gln Arg Pro Gln Leu Gly Ser His Ser Ser His Gly Pro Ser Pro
   1               5                  10                  15    
 Ala Cys Ser His Gly Glu Pro Ser Gly Leu Pro Glu His Gln Ser Lys
              20                  25                  30        
 Val Pro Gly Pro Gln Pro Glu Pro Ser Asp Leu Pro Lys Lys Pro Pro
          35                  40                  45            
 Lys Pro Glu Phe Gly Lys Leu Lys Lys Phe Ser Gln Pro Glu Leu Ser
      50                  55                  60                
 Glu His Pro Gln Lys Ala Pro Leu Pro Glu Phe Gly Ala Val Ser Leu
  65                  70                  75                  80
 Lys Pro Pro Gln Pro Gln Phe Thr Asp Leu Pro Lys Lys Pro Pro Pro
                  85                  90                  95    
 Pro Glu Val Thr Asp Leu Pro Lys Lys Pro Pro Pro Pro Glu Val Thr
             100                 105                 110        
 Asp Leu Pro Lys Lys Pro Pro Pro Pro Glu Val Thr Asp Leu Pro Lys
         115                 120                 125            
 Lys Pro Pro Pro Pro Glu Val Thr Asp Leu Pro Lys Lys Pro Ser Lys
     130                 135                 140                
 Leu Glu Leu Ser Asp Leu Ser Lys Lys Phe Pro Gln Leu Gly Ala Thr
 145                 150                 155                 160
 Pro Phe Pro Arg Lys Pro Leu Gln Pro Glu Val Gly Glu Ala Pro Leu
                 165                 170                 175    
 Lys Ala Ser Leu Pro Glu Pro Gly Ala Pro Ala Arg Lys Pro Leu Gln
             180                 185                 190        
 Pro Asp Glu Pro Val Thr Pro Pro Asp Pro Pro Pro Asn Pro Asn Pro
         195                 200                 205            
 Ala His Ser Pro Gly Ser Ser Gly Asn Pro Arg Pro Val Arg Leu Pro
     210                 215                 220                
 Arg Gly Pro
 225        



      <210> 1782
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 1782
 Glu Pro Ile Pro Val Thr Pro Asp His Arg Leu Val Thr Met Thr His
   1               5                  10                  15    
 Ile Val Gln Thr Phe Ser Pro Val Asn Ser Gly Gln Pro Pro Asn Tyr
              20                  25                  30        
 Glu Met Leu Lys Glu Glu Gln Glu Val Ala Met Leu Gly Ala Pro His
          35                  40                  45            
 Asn Pro Ala Pro Pro Met Ser Thr Val Ile His Ile Arg Ser Glu Thr
      50                  55                  60                
 Ser Val Pro Asp His Val Val Trp Ser Leu Phe Asn Thr Leu Phe Met
  65                  70                  75                  80
 Asn Thr Cys Cys Leu Gly Phe Ile Ala Phe Ala Tyr Ser Val Lys Ser
                  85                  90                  95    
 Arg Asp Arg Lys Met Val Gly Asp Val Thr Gly Ala Gln Ala Tyr Ala
             100                 105                 110        
 Ser Thr Ala Lys Cys Leu Asn Ile Trp Ala Leu Ile Leu Gly Ile Phe
         115                 120                 125            
 Met Thr Ile Leu Leu Ile Ile Ile Pro Val Leu Val Val Gln Ala Gln
     130                 135                 140                
 Arg
 145



      <210> 1783
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 1783
 Arg Val Arg Leu Arg Pro Val Phe Cys Val Met Thr Ser Gln Glu Lys
   1               5                  10                  15    
 Thr Glu Glu Tyr Pro Phe Ala Asp Ile Phe Asp Glu Asp Glu Thr Glu
              20                  25                  30        
 Arg Asn Phe Leu Leu Ser Lys Pro Val Cys Phe Val Val Phe Gly Lys
          35                  40                  45            
 Pro Gly Val Gly Lys Thr Thr Leu Ala Arg Tyr Ile Thr Gln Ala Trp
      50                  55                  60                
 Lys Cys Ile Arg Val Glu Ala Leu Pro Ile Leu Glu Glu Gln Ile Ala
  65                  70                  75                  80
 Ala Glu Thr Glu Ser Gly Val Met Leu Gln Ser Met Leu Ile Ser Gly
                  85                  90                  95    
 Gln Ser Ile Pro Asp Glu Leu Val Ile Lys Leu Met Leu Glu Lys Leu
             100                 105                 110        
 Asn Ser Pro Glu Val Cys His Phe Gly Tyr Ile Ile Thr Glu Ile Pro
         115                 120                 125            
 Ser Leu Ser Gln Asp Ala Met Thr Thr Leu Gln Gln Ile Glu Leu Ile
     130                 135                 140                
 Lys Asn Leu Asn Leu Lys Pro Asp Val Ile Ile Asn Ile Lys Gly Val
 145                 150                 155                 160
 Leu Asp Phe
            



      <210> 1784
      <211> 954
      <212> PRT
      <213> Homo sapiens


      <400> 1784
 Ala Leu Pro Asp Gly Gly Ala Ser Val Ala Ser Asp Arg Ala Glu Gly
   1               5                  10                  15    
 Arg Pro Ala Lys Pro Ser Lys Thr Ala Ala Arg Glu Lys Thr Glu Gly
              20                  25                  30        
 Ala Val Ala Ala Val Gly Gly Gly Pro Ser Ser Phe Arg Cys Cys Tyr
          35                  40                  45            
 Gly Cys Cys His Glu Ala Arg Leu Gly Arg Thr Ser Leu Pro Arg Gly
      50                  55                  60                
 Val Ile Met Leu Thr Glu Ala Ser Leu Ser Ile Trp Gly Trp Gly Ser
  65                  70                  75                  80
 Leu Gly Ile Val Leu Phe Leu Ile Thr Phe Gly Pro Phe Val Ile Phe
                  85                  90                  95    
 Tyr Leu Thr Phe Tyr Ile Leu Cys Phe Val Gly Gly Gly Leu Val Val
             100                 105                 110        
 Thr Leu Leu Phe Gly Lys Thr Asn Ser Glu Lys Tyr Leu Glu Gln Cys
         115                 120                 125            
 Glu His Ser Phe Leu Pro Pro Thr Ser Pro Gly Val Pro Lys Cys Leu
     130                 135                 140                
 Glu Glu Met Lys Arg Glu Ala Arg Thr Ile Lys Ile Asp Arg Arg Leu
 145                 150                 155                 160
 Thr Gly Ala Asn Ile Ile Asp Glu Pro Leu Gln Gln Val Ile Gln Phe
                 165                 170                 175    
 Ser Leu Arg Asp Tyr Val Gln Tyr Trp Tyr Tyr Thr Leu Ser Asp Asp
             180                 185                 190        
 Glu Ser Phe Leu Leu Glu Ile Arg Gln Thr Leu Gln Asn Ala Leu Ile
         195                 200                 205            
 Gln Phe Ala Thr Arg Ser Lys Glu Ile Asp Trp Gln Pro Tyr Phe Thr
     210                 215                 220                
 Thr Arg Ile Val Asp Asp Phe Gly Thr His Leu Arg Val Phe Arg Lys
 225                 230                 235                 240
 Ala Gln Gln Lys Ile Thr Glu Lys Asp Asp Gln Val Lys Gly Thr Ala
                 245                 250                 255    
 Glu Asp Leu Val Asp Thr Phe Phe Glu Val Glu Val Glu Met Glu Lys
             260                 265                 270        
 Glu Val Cys Arg Asp Leu Val Cys Thr Ser Pro Lys Asp Glu Glu Gly
         275                 280                 285            
 Phe Leu Arg Asp Leu Cys Glu Val Leu Leu Tyr Leu Leu Leu Pro Pro
     290                 295                 300                
 Gly Asp Phe Gln Asn Lys Ile Met Arg Tyr Phe Val Arg Glu Ile Leu
 305                 310                 315                 320
 Ala Arg Gly Ile Leu Leu Pro Leu Ile Asn Gln Leu Ser Asp Pro Asp
                 325                 330                 335    
 Tyr Ile Asn Gln Tyr Val Ile Trp Met Ile Arg Asp Ser Asn Cys Asn
             340                 345                 350        
 Tyr Glu Ala Phe Met Asn Ile Ile Lys Leu Ser Asp Asn Ile Gly Glu
         355                 360                 365            
 Leu Glu Ala Val Arg Asp Lys Ala Ala Glu Glu Leu Gln Tyr Leu Arg
     370                 375                 380                
 Ser Leu Asp Thr Ala Gly Asp Asp Ile Asn Thr Ile Lys Asn Gln Ile
 385                 390                 395                 400
 Asn Ser Leu Leu Phe Val Lys Lys Val Cys Asp Ser Arg Ile Gln Arg
                 405                 410                 415    
 Leu Gln Ser Gly Lys Glu Ile Asn Thr Val Lys Leu Ala Ala Asn Phe
             420                 425                 430        
 Gly Lys Leu Cys Thr Val Pro Leu Asp Ser Ile Leu Val Asp Asn Val
         435                 440                 445            
 Ala Leu Gln Phe Phe Met Asp Tyr Met Gln Gln Thr Gly Gly Gln Ala
     450                 455                 460                
 His Leu Phe Phe Trp Met Thr Val Glu Gly Tyr Arg Val Thr Ala Gln
 465                 470                 475                 480
 Gln Gln Leu Glu Val Leu Leu Ser Arg Gln Arg Asp Gly Lys His Gln
                 485                 490                 495    
 Thr Asn Gln Thr Lys Gly Leu Leu Arg Ala Ala Ala Val Gly Ile Tyr
             500                 505                 510        
 Glu Gln Tyr Leu Ser Glu Lys Ala Ser Pro Arg Val Thr Val Asp Asp
         515                 520                 525            
 Tyr Leu Val Ala Lys Leu Ala Asp Thr Leu Asn His Glu Asp Pro Thr
     530                 535                 540                
 Pro Glu Ile Phe Asp Asp Ile Gln Arg Lys Val Tyr Glu Leu Met Leu
 545                 550                 555                 560
 Arg Asp Glu Arg Phe Tyr Pro Ser Phe Arg Gln Asn Ala Leu Tyr Val
                 565                 570                 575    
 Arg Met Leu Ala Glu Leu Asp Met Leu Lys Asp Pro Ser Phe Arg Gly
             580                 585                 590        
 Ser Asp Asp Gly Asp Gly Glu Ser Phe Asn Gly Ser Pro Thr Gly Ser
         595                 600                 605            
 Ile Asn Leu Ser Leu Asp Asp Leu Ser Asn Val Ser Ser Asp Asp Ser
     610                 615                 620                
 Val Gln Leu His Ala Tyr Ile Ser Asp Thr Val Tyr Ala Asp Tyr Asp
 625                 630                 635                 640
 Pro Tyr Ala Val Ala Gly Val Cys Asn Asp His Gly Lys Thr Tyr Ala
                 645                 650                 655    
 Leu Tyr Ala Ile Thr Val His Arg Arg Asn Leu Asn Ser Glu Glu Met
             660                 665                 670        
 Trp Lys Thr Tyr Arg Arg Tyr Ser Asp Phe His Asp Phe His Met Arg
         675                 680                 685            
 Ile Thr Glu Gln Phe Glu Ser Leu Ser Ser Ile Leu Lys Leu Pro Glu
     690                 695                 700                
 Lys Lys Thr Phe Asn Asn Met Asp Arg Asp Phe Leu Glu Lys Arg Lys
 705                 710                 715                 720
 Lys Asp Leu Asn Ala Tyr Leu Gln Leu Leu Leu Ala Pro Glu Met Met
                 725                 730                 735    
 Lys Ala Ser Pro Ala Leu Ala His Tyr Val Tyr Asp Phe Leu Glu Asn
             740                 745                 750        
 Lys Ala Tyr Ser Lys Gly Lys Gly Asp Phe Ala Arg Lys Met Asp Thr
         755                 760                 765            
 Phe Val Asn Pro Leu Arg Asn Ser Met Arg Asn Val Ser Asn Ala Val
     770                 775                 780                
 Lys Ser Leu Pro Asp Ser Leu Ala Glu Gly Met Thr Lys Met Ser Asp
 785                 790                 795                 800
 Asn Met Gly Lys Met Ser Glu Arg Leu Gly Gln Asp Ile Lys Gln Ser
                 805                 810                 815    
 Phe Phe Lys Val Pro Pro Leu Ile Pro Lys Thr Asp Ser Asp Pro Glu
             820                 825                 830        
 His Arg Arg Val Ser Ala Gln Leu Asp Asp Asn Val Asp Asp Asn Ile
         835                 840                 845            
 Pro Leu Arg Val Met Leu Leu Leu Met Asp Glu Val Phe Asp Leu Lys
     850                 855                 860                
 Glu Arg Asn Gln Trp Leu Arg Arg Asn Ile Lys Asn Leu Leu Gln Gln
 865                 870                 875                 880
 Leu Ile Arg Ala Thr Tyr Gly Asp Thr Ile Asn Arg Lys Ile Val Asp
                 885                 890                 895    
 His Val Asp Trp Met Thr Ser Pro Glu Gln Val Ala Asp Ser Val Lys
             900                 905                 910        
 Arg Phe Arg Asp Ala Phe Trp Pro Asn Gly Ile Leu Ala Glu Ala Val
         915                 920                 925            
 Pro Cys Arg Asp Lys Ser Ile Arg Met Arg Thr Arg Val Ala Gly Lys
     930                 935                 940                
 Thr Lys Leu Leu Ala Ile Met Pro Gly Glu
 945                 950                



      <210> 1785
      <211> 954
      <212> PRT
      <213> Homo sapiens


      <400> 1785
 Ala Leu Pro Asp Gly Gly Ala Ser Val Ala Ser Asp Arg Ala Glu Gly
   1               5                  10                  15    
 Arg Pro Ala Lys Pro Ser Lys Thr Ala Ala Arg Glu Lys Thr Glu Gly
              20                  25                  30        
 Ala Val Ala Ala Val Gly Gly Gly Pro Ser Ser Phe Arg Cys Cys Tyr
          35                  40                  45            
 Gly Cys Cys His Glu Ala Arg Leu Gly Arg Thr Ser Leu Pro Arg Gly
      50                  55                  60                
 Val Ile Met Leu Thr Glu Ala Ser Leu Ser Ile Trp Gly Trp Gly Ser
  65                  70                  75                  80
 Leu Gly Ile Val Leu Phe Leu Ile Thr Phe Gly Pro Phe Val Ile Phe
                  85                  90                  95    
 Tyr Leu Thr Phe Tyr Ile Leu Cys Phe Val Gly Gly Gly Leu Val Val
             100                 105                 110        
 Thr Leu Leu Phe Gly Lys Thr Asn Ser Glu Lys Tyr Leu Glu Gln Cys
         115                 120                 125            
 Glu His Ser Phe Leu Pro Pro Thr Ser Pro Gly Val Pro Lys Cys Leu
     130                 135                 140                
 Glu Glu Met Lys Arg Glu Ala Arg Thr Ile Lys Ile Asp Arg Arg Leu
 145                 150                 155                 160
 Thr Gly Ala Asn Ile Ile Asp Glu Pro Leu Gln Gln Val Ile Gln Phe
                 165                 170                 175    
 Ser Leu Arg Asp Tyr Val Gln Tyr Trp Tyr Tyr Thr Leu Ser Asp Asp
             180                 185                 190        
 Glu Ser Phe Leu Leu Glu Ile Arg Gln Thr Leu Gln Asn Ala Leu Ile
         195                 200                 205            
 Gln Phe Ala Thr Arg Ser Lys Glu Ile Asp Trp Gln Pro Tyr Phe Thr
     210                 215                 220                
 Thr Arg Ile Val Asp Asp Phe Gly Thr His Leu Arg Val Phe Arg Lys
 225                 230                 235                 240
 Ala Gln Gln Lys Ile Thr Glu Lys Asp Asp Gln Val Lys Gly Thr Ala
                 245                 250                 255    
 Glu Asp Leu Val Asp Thr Phe Phe Glu Val Glu Val Glu Met Glu Lys
             260                 265                 270        
 Glu Val Cys Arg Asp Leu Val Cys Thr Ser Pro Lys Asp Glu Glu Gly
         275                 280                 285            
 Phe Leu Arg Asp Leu Cys Glu Val Leu Leu Tyr Leu Leu Leu Pro Pro
     290                 295                 300                
 Gly Asp Phe Gln Asn Lys Ile Met Arg Tyr Phe Val Arg Glu Ile Leu
 305                 310                 315                 320
 Ala Arg Gly Ile Leu Leu Pro Leu Ile Asn Gln Leu Ser Asp Pro Asp
                 325                 330                 335    
 Tyr Ile Asn Gln Tyr Val Ile Trp Met Ile Arg Asp Ser Asn Cys Asn
             340                 345                 350        
 Tyr Glu Ala Phe Met Asn Ile Ile Lys Leu Ser Asp Asn Ile Gly Glu
         355                 360                 365            
 Leu Glu Ala Val Arg Asp Lys Ala Ala Glu Glu Leu Gln Tyr Leu Arg
     370                 375                 380                
 Ser Leu Asp Thr Ala Gly Asp Asp Ile Asn Thr Ile Lys Asn Gln Ile
 385                 390                 395                 400
 Asn Ser Leu Leu Phe Val Lys Lys Val Cys Asp Ser Arg Ile Gln Arg
                 405                 410                 415    
 Leu Gln Ser Gly Lys Glu Ile Asn Thr Val Lys Leu Ala Ala Asn Phe
             420                 425                 430        
 Gly Lys Leu Cys Thr Val Pro Leu Asp Ser Ile Leu Val Asp Asn Val
         435                 440                 445            
 Ala Leu Gln Phe Phe Met Asp Tyr Met Gln Gln Thr Gly Gly Gln Ala
     450                 455                 460                
 His Leu Phe Phe Trp Met Thr Val Glu Gly Tyr Arg Val Thr Ala Gln
 465                 470                 475                 480
 Gln Gln Leu Glu Val Leu Leu Ser Arg Gln Arg Asp Gly Lys His Gln
                 485                 490                 495    
 Thr Asn Gln Thr Lys Gly Leu Leu Arg Ala Ala Ala Val Gly Ile Tyr
             500                 505                 510        
 Glu Gln Tyr Leu Ser Glu Lys Ala Ser Pro Arg Val Thr Val Asp Asp
         515                 520                 525            
 Tyr Leu Val Ala Lys Leu Ala Asp Thr Leu Asn His Glu Asp Pro Thr
     530                 535                 540                
 Pro Glu Ile Phe Asp Asp Ile Gln Arg Lys Val Tyr Glu Leu Met Leu
 545                 550                 555                 560
 Arg Asp Glu Arg Phe Tyr Pro Ser Phe Arg Gln Asn Ala Leu Tyr Val
                 565                 570                 575    
 Arg Met Leu Ala Glu Leu Asp Met Leu Lys Asp Pro Ser Phe Arg Gly
             580                 585                 590        
 Ser Asp Asp Gly Asp Gly Glu Ser Phe Asn Gly Ser Pro Thr Gly Ser
         595                 600                 605            
 Ile Asn Leu Ser Leu Asp Asp Leu Ser Asn Val Ser Ser Asp Asp Ser
     610                 615                 620                
 Val Gln Leu His Ala Tyr Ile Ser Asp Thr Val Tyr Ala Asp Tyr Asp
 625                 630                 635                 640
 Pro Tyr Ala Val Ala Gly Val Cys Asn Asp His Gly Lys Thr Tyr Ala
                 645                 650                 655    
 Leu Tyr Ala Ile Thr Val His Arg Arg Asn Leu Asn Ser Glu Glu Met
             660                 665                 670        
 Trp Lys Thr Tyr Arg Arg Tyr Ser Asp Phe His Asp Phe His Met Arg
         675                 680                 685            
 Ile Thr Glu Gln Phe Glu Ser Leu Ser Ser Ile Leu Lys Leu Pro Glu
     690                 695                 700                
 Lys Lys Thr Phe Asn Asn Met Asp Arg Asp Phe Leu Glu Lys Arg Lys
 705                 710                 715                 720
 Lys Asp Leu Asn Ala Tyr Leu Gln Leu Leu Leu Ala Pro Glu Met Met
                 725                 730                 735    
 Lys Ala Ser Pro Ala Leu Ala His Tyr Val Tyr Asp Phe Leu Glu Asn
             740                 745                 750        
 Lys Ala Tyr Ser Lys Gly Lys Gly Asp Phe Ala Arg Lys Met Asp Thr
         755                 760                 765            
 Phe Val Asn Pro Leu Arg Asn Ser Met Arg Asn Val Ser Asn Ala Val
     770                 775                 780                
 Lys Ser Leu Pro Asp Ser Leu Ala Glu Gly Met Thr Lys Met Ser Asp
 785                 790                 795                 800
 Asn Met Gly Lys Met Ser Glu Arg Leu Gly Gln Asp Ile Lys Gln Ser
                 805                 810                 815    
 Phe Phe Lys Val Pro Pro Leu Ile Pro Lys Thr Asp Ser Asp Pro Glu
             820                 825                 830        
 His Arg Arg Val Ser Ala Gln Leu Asp Asp Asn Val Asp Asp Asn Ile
         835                 840                 845            
 Pro Leu Arg Val Met Leu Leu Leu Met Asp Glu Val Phe Asp Leu Lys
     850                 855                 860                
 Glu Arg Asn Gln Trp Leu Arg Arg Asn Ile Lys Asn Leu Leu Gln Gln
 865                 870                 875                 880
 Leu Ile Arg Ala Thr Tyr Gly Asp Thr Ile Asn Arg Lys Ile Val Asp
                 885                 890                 895    
 His Val Asp Trp Met Thr Ser Pro Glu Gln Val Ala Asp Ser Val Lys
             900                 905                 910        
 Arg Phe Arg Asp Ala Phe Trp Pro Asn Gly Ile Leu Ala Glu Ala Val
         915                 920                 925            
 Pro Cys Arg Asp Lys Ser Ile Arg Met Arg Thr Arg Val Ala Gly Lys
     930                 935                 940                
 Thr Lys Leu Leu Ala Ile Met Pro Gly Glu
 945                 950                



      <210> 1786
      <211> 208
      <212> PRT
      <213> Homo sapiens


      <400> 1786
 Val Trp Pro Glu Val Thr Asp Pro Glu Lys Phe Val Tyr Glu Asp Val
   1               5                  10                  15    
 Ala Ile Ala Ala Tyr Leu Leu Ile Leu Trp Glu Glu Glu Arg Ala Glu
              20                  25                  30        
 Arg Gly Leu Thr Ala Arg Gln Ser Phe Val Asp Leu Gly Cys Gly Asn
          35                  40                  45            
 Gly Leu Leu Val His Ile Leu Ser Ser Glu Gly His Pro Gly Arg Gly
      50                  55                  60                
 Ile Asp Val Arg Arg Arg Lys Ile Trp Asp Met Tyr Gly Pro Gln Thr
  65                  70                  75                  80
 Gln Leu Glu Glu Asp Ala Ile Thr Pro Asn Asp Lys Thr Leu Phe Pro
                  85                  90                  95    
 Asp Val Asp Trp Leu Ile Gly Asn His Ser Asp Glu Leu Thr Pro Trp
             100                 105                 110        
 Ile Pro Val Ile Ala Ala Arg Ser Ser Tyr Asn Cys Arg Phe Phe Val
         115                 120                 125            
 Leu Pro Cys Cys Phe Phe Asp Phe Ile Gly Arg Tyr Ser Arg Arg Gln
     130                 135                 140                
 Ser Lys Lys Thr Gln Tyr Arg Glu Tyr Leu Asp Phe Ile Lys Glu Val
 145                 150                 155                 160
 Gly Phe Thr Cys Gly Phe His Val Asp Glu Asp Cys Leu Arg Ile Pro
                 165                 170                 175    
 Ser Thr Thr Arg Val Cys Leu Val Gly Lys Ser Arg Thr Tyr Pro Tyr
             180                 185                 190        
 Ser Ile Glu Ala Ser Val Asp Glu Lys Arg Thr Gln Tyr Ile Lys Ser
         195                 200                 205            



      <210> 1787
      <211> 106
      <212> PRT
      <213> Homo sapiens


      <400> 1787
 Gln Ser Tyr Ile Trp Ile Pro Thr Val Trp Leu Ser Arg Gly Phe His
   1               5                  10                  15    
 Phe Phe Leu Thr Ser Val Arg Phe Cys Cys Ile Leu Ile Thr Gln Ala
              20                  25                  30        
 Lys His Leu Leu Gln Gln Met Leu Phe Ser Arg Lys Arg Met Glu Thr
          35                  40                  45            
 Ser Thr Tyr Val Glu Arg Val Lys Ile Pro Leu Asp His Gly Thr Leu
      50                  55                  60                
 Leu Ile Met Glu Gly Ala Thr Gln Ala Asp Trp Gln His Arg Val Pro
  65                  70                  75                  80
 Lys Glu Tyr His Ser Arg Glu Pro Arg Val Asn Leu Thr Phe Arg Thr
                  85                  90                  95    
 Val Tyr Pro Asp Pro Arg Gly Ala Pro Trp
             100                 105    



      <210> 1788
      <211> 423
      <212> PRT
      <213> Homo sapiens


      <400> 1788
 Ser Cys Arg Ala Met Trp Pro Gly Asn Ala Trp Arg Ala Ala Leu Phe
   1               5                  10                  15    
 Trp Val Pro Arg Gly Arg Arg Ala Gln Ser Ala Leu Ala Gln Leu Arg
              20                  25                  30        
 Gly Ile Leu Glu Gly Glu Leu Glu Gly Ile Cys Gly Ala Gly Thr Trp
          35                  40                  45            
 Lys Ser Glu Arg Val Ile Thr Ser Arg Gln Gly Pro His Ile Arg Val
      50                  55                  60                
 Asp Gly Val Ser Gly Gly Ile Leu Asn Phe Cys Ala Asn Asn Tyr Leu
  65                  70                  75                  80
 Gly Leu Ser Ser His Pro Glu Val Ile Gln Ala Gly Leu Gln Ala Leu
                  85                  90                  95    
 Glu Glu Phe Gly Ala Gly Leu Ser Ser Val Arg Phe Ile Cys Gly Thr
             100                 105                 110        
 Gln Ser Ile His Lys Asn Leu Glu Ala Lys Ile Ala Arg Phe His Gln
         115                 120                 125            
 Arg Glu Asp Ala Ile Leu Tyr Pro Ser Cys Tyr Asp Ala Asn Ala Gly
     130                 135                 140                
 Leu Phe Glu Ala Leu Leu Thr Pro Glu Asp Ala Val Leu Ser Asp Glu
 145                 150                 155                 160
 Leu Asn His Ala Ser Ile Ile Asp Gly Ile Arg Leu Cys Lys Ala His
                 165                 170                 175    
 Lys Tyr Arg Tyr Arg His Leu Asp Met Ala Asp Leu Glu Ala Lys Leu
             180                 185                 190        
 Gln Glu Ala Gln Lys His Arg Leu Arg Leu Val Ala Thr Asp Gly Ala
         195                 200                 205            
 Phe Ser Met Asp Gly Asp Ile Ala Pro Leu Gln Glu Ile Cys Cys Leu
     210                 215                 220                
 Ala Ser Arg Tyr Gly Ala Leu Val Phe Met Asp Glu Cys His Ala Thr
 225                 230                 235                 240
 Gly Phe Leu Gly Pro Thr Gly Arg Gly Thr Asp Glu Leu Leu Gly Val
                 245                 250                 255    
 Met Asp Gln Val Thr Ile Ile Asn Ser Thr Leu Gly Lys Ala Leu Gly
             260                 265                 270        
 Gly Ala Ser Gly Gly Tyr Thr Thr Gly Pro Gly Pro Leu Val Ser Leu
         275                 280                 285            
 Leu Arg Gln Arg Ala Arg Pro Tyr Leu Phe Ser Asn Ser Leu Pro Pro
     290                 295                 300                
 Ala Val Val Gly Cys Ala Ser Lys Ala Leu Asp Leu Leu Met Gly Ser
 305                 310                 315                 320
 Asn Thr Ile Val Gln Ser Met Ala Ala Lys Thr Gln Arg Phe Arg Ser
                 325                 330                 335    
 Lys Met Glu Ala Ala Gly Phe Thr Ile Ser Gly Ala Ser His Pro Ile
             340                 345                 350        
 Cys Pro Val Met Leu Gly Asp Ala Arg Leu Ala Ser Arg Met Ala Asp
         355                 360                 365            
 Asp Met Leu Lys Arg Gly Ile Phe Val Ile Gly Phe Ser Tyr Pro Val
     370                 375                 380                
 Val Pro Lys Gly Lys Ala Arg Ile Arg Val Gln Ile Ser Ala Val His
 385                 390                 395                 400
 Ser Glu Glu Asp Ile Asp Arg Cys Val Glu Ala Phe Val Glu Val Gly
                 405                 410                 415    
 Arg Leu His Gly Ala Leu Pro
             420            



      <210> 1789
      <211> 552
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(552)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1789
 Asp Ala Trp Ala Leu Ala Ser Leu Pro Ala Ser Gly Cys Leu Glu Cys
   1               5                  10                  15    
 Leu Val Leu Gln Ala Pro Ser Gly Ser Asp Lys Ala Gly Thr Met Ser
              20                  25                  30        
 Thr Phe Gly Tyr Arg Arg Gly Leu Ser Lys Tyr Glu Ser Ile Asp Glu
          35                  40                  45            
 Asp Glu Leu Leu Ala Ser Leu Ser Ala Glu Glu Leu Lys Glu Leu Glu
      50                  55                  60                
 Arg Glu Leu Glu Asp Ile Glu Pro Tyr Arg Asn Leu Pro Val Gly Leu
  65                  70                  75                  80
 Arg Gln Lys Ser Leu Thr Glu Lys Thr Pro Thr Gly Ala Phe Ser Arg
                  85                  90                  95    
 Glu Ala Leu Met Ala Tyr Trp Glu Lys Glu Ser Gln Lys Leu Leu Glu
             100                 105                 110        
 Lys Glu Arg Leu Gly Glu Cys Gly Lys Val Ala Glu Asp Lys Glu Glu
         115                 120                 125            
 Ser Glu Glu Glu Leu Ile Phe Thr Glu Ser Asn Ser Glu Val Ser Glu
     130                 135                 140                
 Glu Val Tyr Thr Glu Glu Arg Gly Gly Gly Val Pro Gly Gly Arg Gly
 145                 150                 155                 160
 Gly Arg Arg Gln Xaa Arg Arg Gly Lys Asn Asn Xaa Asn Cys Lys Arg
                 165                 170                 175    
 Asp Xaa Trp Asn Cys Lys Leu Xaa Xaa Cys Gln Phe Xaa Gln Leu Xaa
             180                 185                 190        
 Ala Lys Asp Ile Xaa Lys Ser Asn Arg Glu His Lys Leu Thr Asn Gly
         195                 200                 205            
 Ser Asn Gly Arg Asn Thr Glu Ser Pro Ala Ala Ile His Pro Cys Gly
     210                 215                 220                
 Asn Pro Thr Val Ile Glu Asp Ala Leu Asp Lys Ile Lys Ser Asn Asp
 225                 230                 235                 240
 Pro Asp Thr Thr Glu Val Asn Leu Asn Asn Ile Glu Asn Ile Thr Thr
                 245                 250                 255    
 Gln Thr Leu Thr Arg Phe Ala Glu Ala Leu Lys Asp Asn Thr Val Val
             260                 265                 270        
 Lys Thr Phe Ser Leu Ala Asn Thr His Ala Asp Asp Ser Ala Ala Met
         275                 280                 285            
 Ala Ile Ala Glu Met Leu Lys Val Asn Glu His Ile Thr Asn Val Asn
     290                 295                 300                
 Val Glu Ser Asn Phe Ile Thr Gly Lys Gly Ile Leu Ala Ile Met Arg
 305                 310                 315                 320
 Ala Leu Gln His Asn Thr Val Leu Thr Glu Leu Arg Phe His Asn Gln
                 325                 330                 335    
 Arg His Ile Met Gly Ser Gln Val Glu Met Glu Ile Val Lys Leu Leu
             340                 345                 350        
 Lys Glu Asn Thr Thr Leu Leu Arg Leu Gly Tyr His Phe Glu Leu Pro
         355                 360                 365            
 Gly Pro Arg Met Ser Met Thr Ser Ile Leu Thr Arg Asn Met Asp Lys
     370                 375                 380                
 Gln Arg Gln Lys Arg Leu Gln Glu Gln Lys Gln Gln Glu Gly Tyr Asp
 385                 390                 395                 400
 Gly Gly Pro Asn Leu Arg Thr Lys Val Trp Gln Arg Gly Thr Pro Ser
                 405                 410                 415    
 Ser Ser Pro Tyr Val Ser Pro Arg His Ser Pro Trp Ser Ser Pro Lys
             420                 425                 430        
 Pro Pro Pro Pro Pro Pro Ser Ser Gln Arg Leu Pro Pro Pro Pro Pro
         435                 440                 445            
 Pro Pro Pro Pro Pro Leu Pro Glu Lys Lys Leu Ile Thr Arg Asn Ile
     450                 455                 460                
 Ala Glu Val Ile Lys Gln Gln Glu Ser Ala Gln Arg Ala Leu Gln Asn
 465                 470                 475                 480
 Gly Gln Lys Lys Lys Lys Gly Lys Lys Val Lys Lys Gln Pro Asn Ser
                 485                 490                 495    
 Ile Leu Lys Glu Ile Lys Asn Ser Leu Arg Ser Val Gln Glu Lys Lys
             500                 505                 510        
 Met Glu Asp Ser Ser Arg Pro Ser Thr Pro Gln Arg Ser Ala His Glu
         515                 520                 525            
 Asn Leu Met Glu Ala Ile Arg Gly Ser Ser Ile Lys Gln Leu Lys Arg
     530                 535                 540                
 Val Glu Val Pro Glu Ala Leu Arg
 545                 550        



      <210> 1790
      <211> 61
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(61)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1790
 Glu His Ser Thr Leu Lys Leu Pro Tyr His Thr Gln Glu Ala Gly Ala
   1               5                  10                  15    
 Ala Pro Gly Pro Thr Gly Thr Asp Ser His Glu Val Asp His Leu Glu
              20                  25                  30        
 Gly Gly Ala Gly Lys Glu Ala Gly Pro Cys Ala Xaa Ser Leu Gly Thr
          35                  40                  45            
 Met Val Ala Pro Val Arg Ser Asn Ser Gly Ser Pro Glu
      50                  55                  60    



      <210> 1791
      <211> 26
      <212> PRT
      <213> Homo sapiens


      <400> 1791
 Met Arg Cys Ala Ser Pro Ser Thr Ser Lys Glu Phe Ser Cys Ala Leu
   1               5                  10                  15    
 Leu Leu Gln Cys Trp Leu Gln Asp Leu Gly
              20                  25    



      <210> 1792
      <211> 178
      <212> PRT
      <213> Homo sapiens


      <400> 1792
 Lys Arg Arg Gly Ser Phe Lys Met Ala Glu Leu Asp Gln Leu Pro Asp
   1               5                  10                  15    
 Glu Ser Ser Ser Ala Lys Ala Leu Val Ser Leu Lys Glu Gly Ser Leu
              20                  25                  30        
 Ser Asn Thr Trp Asn Glu Lys Tyr Ser Ser Leu Gln Lys Thr Pro Val
          35                  40                  45            
 Trp Lys Gly Arg Asn Thr Ser Ser Ala Val Glu Met Pro Phe Arg Asn
      50                  55                  60                
 Ser Lys Arg Ser Arg Leu Phe Ser Asp Glu Asp Asp Arg Gln Ile Asn
  65                  70                  75                  80
 Thr Arg Ser Pro Lys Arg Asn Gln Arg Val Ala Met Val Pro Gln Lys
                  85                  90                  95    
 Phe Thr Ala Thr Met Ser Thr Pro Asp Lys Lys Ala Ser Gln Lys Ile
             100                 105                 110        
 Gly Phe Arg Leu Arg Asn Leu Leu Lys Leu Pro Lys Ala His Lys Trp
         115                 120                 125            
 Cys Ile Tyr Glu Trp Phe Tyr Ser Asn Ile Asp Lys Pro Leu Phe Glu
     130                 135                 140                
 Gly Asp Asn Asp Phe Cys Val Cys Leu Lys Glu Ser Phe Pro Asn Leu
 145                 150                 155                 160
 Lys Thr Arg Lys Leu Thr Arg Val Glu Trp Gly Lys Ile Arg Arg Leu
                 165                 170                 175    
 Met Gly
        



      <210> 1793
      <211> 247
      <212> PRT
      <213> Homo sapiens


      <400> 1793
 Arg Pro Pro Lys Thr Pro Pro Cys Pro Pro Ser Cys Ser Cys Thr Arg
   1               5                  10                  15    
 Asp Thr Ala Phe Cys Val Asp Ser Lys Ser Val Pro Arg Asn Leu Pro
              20                  25                  30        
 Ser Glu Val Ile Ser Leu Thr Leu Val Asn Ala Ala Phe Ser Glu Ile
          35                  40                  45            
 Gln Asp Gly Ala Phe Ser His Leu Pro Leu Leu Gln Phe Val Leu Leu
      50                  55                  60                
 Asn Ser Asn Lys Phe Thr Leu Ile Gly Asp Asn Ala Phe Thr Gly Leu
  65                  70                  75                  80
 Ser His Leu Gln Tyr Leu Phe Ile Glu Asn Asn Asp Ile Trp Ala Leu
                  85                  90                  95    
 Ser Lys Phe Thr Phe Arg Gly Leu Lys Ser Leu Thr His Leu Ser Leu
             100                 105                 110        
 Ala Asn Asn Asn Leu Gln Thr Leu Pro Arg Asp Ile Phe Arg Pro Leu
         115                 120                 125            
 Asp Ile Leu Asn Asp Leu Asp Leu Arg Gly Asn Ser Leu Asn Cys Asp
     130                 135                 140                
 Cys Lys Val Lys Trp Leu Val Glu Trp Leu Ala His Thr Asn Thr Thr
 145                 150                 155                 160
 Val Ala Pro Ile Tyr Cys Ala Ser Pro Pro Arg Phe Gln Glu His Lys
                 165                 170                 175    
 Val Gln Asp Leu Pro Leu Arg Glu Phe Asp Cys Ile Thr Thr Asp Phe
             180                 185                 190        
 Val Leu Tyr Gln Thr Leu Ala Leu Pro Ala Val Ala Ala Glu Pro Phe
         195                 200                 205            
 Leu Tyr Ser Ser Asp Leu Tyr Leu Ala Leu Ala His Pro Gly Val Ser
     210                 215                 220                
 Ala Cys Thr Ile Leu Lys Trp Asp Tyr Val Glu Arg Gln Leu Arg Asp
 225                 230                 235                 240
 Tyr Tyr Arg Ile Pro Ala Pro
                 245        



      <210> 1794
      <211> 94
      <212> PRT
      <213> Homo sapiens


      <400> 1794
 Thr Arg Leu Arg Ala Gly His Arg Gly Thr Asn Gly His His Phe Ser
   1               5                  10                  15    
 Pro Ser Cys Arg Gln Leu Pro Asp Pro Ala Ile Glu Asp Gln Gly Gly
              20                  25                  30        
 Glu Tyr Val Gln Pro Met Leu Ser Lys Tyr Ala Ala Val Cys Val Arg
          35                  40                  45            
 Cys Pro Gly Tyr Gly Thr Arg Thr Asn Thr Ile Ile Leu Val Asp Ala
      50                  55                  60                
 Asp Gly His Val Thr Phe Thr Glu Arg Ser Met Met Asp Lys Asp Leu
  65                  70                  75                  80
 Ser His Trp Glu Thr Arg Thr Tyr Glu Phe Thr Leu Gln Ser
                  85                  90                



      <210> 1795
      <211> 888
      <212> PRT
      <213> Homo sapiens


      <400> 1795
 Arg Gln Gly Gly Thr His Ala Tyr Lys Gly His Glu Arg Leu Gly Ala
   1               5                  10                  15    
 Ala Arg Met Thr Ser Ala Gln Cys Pro Ala Leu Ala Cys Val Met Ser
              20                  25                  30        
 Pro Leu Arg Phe Trp Gly Pro Trp Pro Leu Leu Met Trp Gln Leu Leu
          35                  40                  45            
 Trp Leu Leu Val Lys Glu Ala Gln Pro Leu Glu Trp Val Lys Asp Pro
      50                  55                  60                
 Leu Gln Leu Thr Ser Asn Pro Leu Gly Pro Pro Glu Pro Trp Ser Ser
  65                  70                  75                  80
 His Ser Ser His Phe Pro Arg Glu Ser Pro His Ala Pro Thr Leu Pro
                  85                  90                  95    
 Ala Asp Pro Trp Asp Phe Asp His Leu Gly Pro Ser Ala Ser Ser Glu
             100                 105                 110        
 Met Pro Ala Pro Pro Gln Glu Ser Thr Glu Asn Leu Val Pro Phe Leu
         115                 120                 125            
 Asp Thr Trp Asp Ser Ala Gly Glu Leu Pro Leu Glu Pro Glu Gln Phe
     130                 135                 140                
 Leu Ala Ser Gln Gln Asp Leu Lys Asp Lys Leu Ser Pro Gln Glu Arg
 145                 150                 155                 160
 Leu Pro Val Ser Pro Lys Lys Leu Lys Lys Asp Pro Ala Gln Arg Trp
                 165                 170                 175    
 Ser Leu Ala Glu Ile Ile Gly Ile Ile His Gln Leu Ser Thr Pro Gln
             180                 185                 190        
 Ser Gln Lys Gln Thr Leu Gln Asn Glu Tyr Ser Ser Thr Asp Thr Pro
         195                 200                 205            
 Tyr Pro Gly Ser Leu Pro Pro Glu Leu Arg Val Lys Ser Asp Glu Pro
     210                 215                 220                
 Pro Gly Pro Ser Glu Gln Val Gly Pro Ser Gln Phe His Leu Glu Pro
 225                 230                 235                 240
 Glu Thr Gln Asn Pro Glu Thr Leu Glu Asp Ile Gln Ser Ser Ser Leu
                 245                 250                 255    
 Gln Gln Glu Ala Pro Ala Gln Leu Pro Gln Leu Leu Glu Glu Glu Pro
             260                 265                 270        
 Ser Ser Met Gln Gln Glu Ala Pro Ala Leu Pro Pro Glu Ser Ser Met
         275                 280                 285            
 Glu Ser Leu Thr Leu Pro Asn His Glu Val Ser Val Gln Pro Pro Gly
     290                 295                 300                
 Glu Asp Gln Ala Tyr Tyr His Leu Pro Asn Ile Thr Val Lys Pro Ala
 305                 310                 315                 320
 Asp Val Glu Val Thr Ile Thr Ser Glu Pro Thr Asn Glu Thr Glu Ser
                 325                 330                 335    
 Ser Gln Thr Gln Gln Glu Thr Pro Ile Gln Phe Pro Glu Glu Val Glu
             340                 345                 350        
 Pro Ser Ala Thr Gln Gln Glu Ala Pro Ile Glu Pro Pro Val Pro Pro
         355                 360                 365            
 Met Glu His Glu Leu Ser Ile Ser Glu Gln Gln Gln Pro Val Gln Pro
     370                 375                 380                
 Ser Glu Thr Ser Arg Glu Val Glu Ser Ser Pro Thr Gln Gln Glu Thr
 385                 390                 395                 400
 Pro Gly Gln Pro Pro Glu His His Glu Val Thr Val Ser Pro Pro Gly
                 405                 410                 415    
 His His Gln Thr His His Leu Asp Ser Pro Ser Val Ser Val Lys Pro
             420                 425                 430        
 Pro Asp Val Gln Leu Thr Ile Ala Ala Glu Pro Ser Ala Glu Val Gly
         435                 440                 445            
 Thr Ser Leu Val Gln Gln Glu Ala Thr Thr Arg Leu Ser Gly Ser Gly
     450                 455                 460                
 Asn Asp Ile Glu Pro Pro Ala Ile Gln His Gly Gly Pro Pro Leu Leu
 465                 470                 475                 480
 Ser Glu Ser Ser Glu Glu Ala Gly Pro Leu Ala Val Gln Gln Glu Thr
                 485                 490                 495    
 Ser Phe Gln Ser Pro Glu Pro Ile Asn Asn Glu Asn Pro Ser Pro Thr
             500                 505                 510        
 Gln Gln Glu Ala Ala Ala Glu His Pro Gln Thr Ala Glu Glu Gly Glu
         515                 520                 525            
 Ser Ser Leu Thr His Gln Glu Ala Pro Ala Gln Thr Pro Glu Phe Pro
     530                 535                 540                
 Asn Val Val Val Ala Gln Pro Pro Glu His Ser His Leu Thr Gln Ala
 545                 550                 555                 560
 Thr Val Gln Pro Leu Asp Leu Gly Phe Thr Ile Thr Pro Glu Ser Met
                 565                 570                 575    
 Thr Glu Val Glu Leu Ser Pro Thr Met Lys Glu Thr Pro Thr Gln Pro
             580                 585                 590        
 Pro Lys Lys Val Val Pro Gln Leu Arg Val Tyr Gln Gly Val Thr Asn
         595                 600                 605            
 Pro Thr Pro Gly Gln Asp Gln Ala Gln His Pro Val Ser Pro Ser Val
     610                 615                 620                
 Thr Val Gln Leu Leu Asp Leu Gly Leu Thr Ile Thr Pro Glu Pro Thr
 625                 630                 635                 640
 Thr Glu Val Gly His Ser Thr Pro Pro Lys Arg Thr Ile Val Ser Pro
                 645                 650                 655    
 Lys His Pro Glu Val Thr Leu Pro His Pro Asp Gln Val Gln Thr Gln
             660                 665                 670        
 His Ser His Leu Thr Arg Ala Thr Val Gln Pro Leu Asp Leu Gly Phe
         675                 680                 685            
 Thr Ile Thr Pro Lys Ser Met Thr Glu Val Glu Pro Ser Thr Ala Leu
     690                 695                 700                
 Met Thr Thr Ala Pro Pro Pro Gly His Pro Glu Val Thr Leu Pro Pro
 705                 710                 715                 720
 Ser Asp Lys Gly Gln Ala Gln His Ser His Leu Thr Gln Ala Thr Val
                 725                 730                 735    
 Gln Pro Leu Asp Leu Glu Leu Thr Ile Thr Thr Lys Pro Thr Thr Glu
             740                 745                 750        
 Val Lys Pro Ser Pro Thr Thr Glu Glu Thr Ser Thr Gln Leu Pro Asp
         755                 760                 765            
 Leu Gly Leu Ala Ile Ile Pro Glu Pro Thr Thr Glu Thr Gly His Ser
     770                 775                 780                
 Thr Gly Leu Glu Lys Thr Thr Ala Pro Arg Pro Asp Arg Val Gln Thr
 785                 790                 795                 800
 Leu His Arg Ser Leu Thr Glu Val Thr Gly Pro Pro Thr Glu Leu Glu
                 805                 810                 815    
 Pro Ala Gln Asp Ser Leu Val Gln Ser Glu Ser Tyr Thr Gln Asn Lys
             820                 825                 830        
 Ala Leu Thr Ala Pro Glu Glu His Lys Ala Ser Thr Ser Thr Asn Ile
         835                 840                 845            
 Cys Glu Leu Cys Thr Cys Gly Asp Glu Met Leu Ser Cys Ile Asp Leu
     850                 855                 860                
 Asn Pro Glu Gln Arg Leu Arg Gln Val Pro Val Pro Glu Pro Asn Thr
 865                 870                 875                 880
 His Asn Gly Thr Phe Thr Ile Leu
                 885            



      <210> 1796
      <211> 387
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(387)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1796
 Glu Ser Glu Asn Ser Asn Thr Phe Arg Ser Lys Ser Gly Lys Asp Ala
   1               5                  10                  15    
 Ser Phe Glu Ser Gly Ala Gly Asp Asn Thr Ser Ile Lys Asp Lys Phe
              20                  25                  30        
 Glu Ala Ala Gly Gly Val Asp Ile Gly Ser Trp Phe Cys Ala Gly Asn
          35                  40                  45            
 Glu Asn Thr Ser Glu Asp Lys Ser Ala Pro Lys Ala Lys Ala Lys Lys
      50                  55                  60                
 Ser Ser Glu Ser Arg Gly Ile Tyr Pro Tyr Met Val Pro Gly Ala Gly
  65                  70                  75                  80
 Met Gly Ser Trp Asp Gly Ala Met Ile Trp Ser Glu Thr Lys Phe Ala
                  85                  90                  95    
 His Gln Ser Glu Ala Ser Phe Pro Val Glu Asp Glu Ser Arg Lys Gln
             100                 105                 110        
 Thr Arg Thr Gly Glu Lys Thr Arg Pro Trp Ser Cys Arg Cys Lys His
         115                 120                 125            
 Glu Ala Asn Met Asp Pro Arg Asp Leu Glu Lys Leu Ile Cys Met Ile
     130                 135                 140                
 Glu Met Thr Glu Asp Pro Ser Val His Glu Ile Ala Asn Asn Ala Leu
 145                 150                 155                 160
 Tyr Asn Ser Ala Asp Tyr Ser Tyr Ser His Glu Val Val Arg Asn Val
                 165                 170                 175    
 Gly Gly Ile Ser Val Ile Glu Ser Leu Leu Asn Asn Pro Tyr Pro Ser
             180                 185                 190        
 Val Arg Gln Lys Ala Leu Asn Ala Leu Asn Asn Ile Ser Val Gly Ser
         195                 200                 205            
 Glu Asn His Arg Lys Val Lys Thr Tyr Leu Asn Gln Val Cys Glu Asp
     210                 215                 220                
 Thr Val Thr Tyr Pro Leu Asn Ser Asn Val Gln Leu Ala Gly Leu Arg
 225                 230                 235                 240
 Leu Ile Arg His Leu Thr Ile Thr Ser Glu Tyr Gln His Met Val Thr
                 245                 250                 255    
 Asn Tyr Ile Ser Glu Phe Leu Arg Leu Leu Ser Gly Gly Glu Val Gly
             260                 265                 270        
 Glu Thr Xaa Arg Thr Leu Phe Leu Gly Met Leu Leu Asn Phe Ser Lys
         275                 280                 285            
 Asn Pro Ser Met Thr Lys Asp Leu Leu Ile Ala Asn Ala Pro Thr Ser
     290                 295                 300                
 Leu Ile Asn Ile Phe Ser Lys Lys Glu Thr Lys Glu Asn Ile Leu Asn
 305                 310                 315                 320
 Ala Leu Ser Leu Phe Glu Asn Ile Asn Tyr His Phe Lys Arg Arg Ala
                 325                 330                 335    
 Lys Ala Phe Asn Pro Arg Asp Lys Phe Ser Lys Asn Ser Leu Tyr Phe
             340                 345                 350        
 Leu Phe Gln Arg Pro Lys Ala Cys Ala Lys Lys Leu Arg Ala Leu Ala
         355                 360                 365            
 Ala Glu Cys Asn Asp Pro Glu Val Lys Glu Arg Val Glu Leu Leu Ile
     370                 375                 380                
 Ser Lys Leu
 385        



      <210> 1797
      <211> 1132
      <212> PRT
      <213> Homo sapiens


      <400> 1797
 Cys Gly Arg Ser Phe Ser Val Ile Ser Glu Phe Val Glu His Gln Ile
   1               5                  10                  15    
 Met His Thr Arg Glu Asn Leu Tyr Glu Tyr Gly Glu Ser Phe Ile His
              20                  25                  30        
 Ser Val Ala Val Ser Glu Val Gln Lys Ser Gln Val Gly Gly Lys Arg
          35                  40                  45            
 Phe Glu Cys Lys Asp Cys Gly Glu Thr Phe Asn Lys Ser Ala Ala Leu
      50                  55                  60                
 Ala Glu His Arg Lys Ile His Ala Arg Gly Tyr Leu Val Glu Cys Lys
  65                  70                  75                  80
 Asn Gln Glu Cys Glu Glu Ala Phe Met Pro Ser Pro Thr Phe Ser Glu
                  85                  90                  95    
 Leu Gln Lys Ile Tyr Gly Lys Asp Lys Phe Tyr Glu Cys Arg Val Cys
             100                 105                 110        
 Lys Glu Thr Phe Leu His Ser Ser Ala Leu Ile Glu His Gln Lys Ile
         115                 120                 125            
 His Phe Gly Asp Asp Lys Asp Asn Glu Arg Glu His Glu Arg Glu Arg
     130                 135                 140                
 Glu Arg Glu Arg Gly Glu Thr Phe Arg Pro Ser Pro Ala Leu Asn Glu
 145                 150                 155                 160
 Phe Gln Lys Met Tyr Gly Lys Glu Lys Met Tyr Glu Cys Lys Val Cys
                 165                 170                 175    
 Gly Glu Thr Phe Leu His Ser Ser Ser Leu Lys Glu His Gln Lys Ile
             180                 185                 190        
 His Thr Arg Gly Asn Pro Phe Glu Asn Lys Gly Lys Val Cys Glu Glu
         195                 200                 205            
 Thr Phe Ile Pro Gly Gln Ser Leu Lys Arg Arg Gln Lys Thr Tyr Asn
     210                 215                 220                
 Lys Glu Lys Leu Cys Asp Phe Thr Asp Gly Arg Asp Ala Phe Met Gln
 225                 230                 235                 240
 Ser Ser Glu Leu Ser Glu His Gln Lys Ile His Ser Arg Lys Asn Leu
                 245                 250                 255    
 Phe Glu Gly Arg Gly Tyr Glu Lys Ser Val Ile His Ser Gly Pro Phe
             260                 265                 270        
 Thr Glu Ser Gln Lys Ser His Thr Ile Thr Arg Pro Leu Glu Ser Asp
         275                 280                 285            
 Glu Asp Glu Lys Ala Phe Thr Ile Ser Ser Asn Pro Tyr Glu Asn Gln
     290                 295                 300                
 Lys Ile Pro Thr Lys Glu Asn Val Tyr Glu Ala Lys Ser Tyr Glu Arg
 305                 310                 315                 320
 Ser Val Ile His Ser Leu Ala Ser Val Glu Ala Gln Lys Ser His Ser
                 325                 330                 335    
 Val Ala Gly Pro Ser Lys Pro Lys Val Met Ala Glu Ser Thr Ile Gln
             340                 345                 350        
 Ser Phe Asp Ala Ile Asn His Gln Arg Val Arg Ala Gly Gly Asn Thr
         355                 360                 365            
 Ser Glu Gly Arg Glu Tyr Ser Arg Ser Val Ile His Ser Leu Val Ala
     370                 375                 380                
 Ser Lys Pro Pro Arg Ser His Asn Gly Asn Glu Leu Val Glu Ser Asn
 385                 390                 395                 400
 Glu Lys Gly Glu Ser Ser Ile Tyr Ile Ser Asp Leu Asn Asp Lys Arg
                 405                 410                 415    
 Gln Lys Ile Pro Ala Arg Glu Asn Pro Cys Glu Gly Gly Ser Lys Asn
             420                 425                 430        
 Arg Asn Tyr Glu Asp Ser Val Ile Gln Ser Val Phe Arg Ala Lys Pro
         435                 440                 445            
 Gln Lys Ser Val Pro Gly Glu Gly Ser Gly Glu Phe Lys Lys Asp Gly
     450                 455                 460                
 Glu Phe Ser Val Pro Ser Ser Asn Val Arg Glu Tyr Gln Lys Ala Arg
 465                 470                 475                 480
 Ala Lys Lys Lys Tyr Ile Glu His Arg Ser Asn Glu Thr Ser Val Ile
                 485                 490                 495    
 His Ser Leu Pro Phe Gly Glu Gln Thr Phe Arg Pro Arg Gly Met Leu
             500                 505                 510        
 Tyr Glu Cys Gln Glu Cys Gly Glu Cys Phe Ala His Ser Ser Asp Leu
         515                 520                 525            
 Thr Glu His Gln Lys Ile His Asp Arg Glu Lys Pro Ser Gly Ser Arg
     530                 535                 540                
 Asn Tyr Glu Trp Ser Val Ile Arg Ser Leu Ala Pro Thr Asp Pro Gln
 545                 550                 555                 560
 Thr Ser Tyr Ala Gln Glu Gln Tyr Ala Lys Glu Gln Ala Arg Asn Lys
                 565                 570                 575    
 Cys Lys Asp Phe Arg Gln Phe Phe Ala Thr Ser Glu Asp Leu Asn Thr
             580                 585                 590        
 Asn Gln Lys Ile Tyr Asp Gln Glu Lys Ser His Gly Glu Glu Ser Gln
         595                 600                 605            
 Gly Glu Asn Thr Asp Gly Glu Glu Thr His Ser Glu Glu Thr His Gly
     610                 615                 620                
 Gln Glu Thr Ile Glu Asp Pro Val Ile Gln Gly Ser Asp Met Glu Asp
 625                 630                 635                 640
 Pro Gln Lys Asp Asp Pro Asp Asp Lys Ile Tyr Glu Cys Glu Asp Cys
                 645                 650                 655    
 Gly Leu Gly Phe Val Asp Leu Thr Asp Leu Thr Asp His Gln Lys Val
             660                 665                 670        
 His Ser Arg Lys Cys Leu Val Asp Ser Arg Glu Tyr Thr His Ser Val
         675                 680                 685            
 Ile His Thr His Ser Ile Ser Glu Tyr Gln Arg Asp Tyr Thr Gly Glu
     690                 695                 700                
 Gln Leu Tyr Glu Cys Pro Lys Cys Gly Glu Ser Phe Ile His Ser Ser
 705                 710                 715                 720
 Phe Leu Phe Glu His Gln Arg Ile His Glu Gln Asp Gln Leu Tyr Ser
                 725                 730                 735    
 Met Lys Gly Cys Asp Asp Gly Phe Ile Ala Leu Leu Pro Met Lys Pro
             740                 745                 750        
 Arg Arg Asn Arg Ala Ala Glu Arg Asn Pro Ala Leu Ala Gly Ser Ala
         755                 760                 765            
 Ile Arg Cys Leu Leu Cys Gly Gln Gly Phe Ile His Ser Ser Ala Leu
     770                 775                 780                
 Asn Glu His Met Arg Leu His Arg Glu Asp Asp Leu Leu Glu Gln Ser
 785                 790                 795                 800
 Gln Met Ala Glu Glu Ala Ile Ile Pro Gly Leu Ala Leu Thr Glu Phe
                 805                 810                 815    
 Gln Arg Ser Gln Thr Glu Glu Arg Leu Phe Glu Cys Ala Val Cys Gly
             820                 825                 830        
 Glu Ser Phe Val Asn Pro Ala Glu Leu Ala Asp His Val Thr Val His
         835                 840                 845            
 Lys Asn Glu Pro Tyr Glu Tyr Gly Ser Ser Tyr Thr His Thr Ser Phe
     850                 855                 860                
 Leu Thr Glu Pro Leu Lys Gly Ala Ile Pro Phe Tyr Glu Cys Lys Asp
 865                 870                 875                 880
 Cys Gly Lys Ser Phe Ile His Ser Thr Val Leu Thr Lys His Lys Glu
                 885                 890                 895    
 Leu His Leu Glu Glu Glu Glu Glu Asp Glu Ala Ala Ala Ala Ala Ala
             900                 905                 910        
 Ala Ala Ala Gln Glu Val Glu Ala Asn Val His Val Pro Gln Val Val
         915                 920                 925            
 Leu Arg Ile Gln Gly Leu Asn Val Glu Ala Ala Glu Pro Glu Val Glu
     930                 935                 940                
 Ala Ala Glu Pro Glu Val Glu Ala Ala Glu Pro Glu Val Glu Ala Ala
 945                 950                 955                 960
 Glu Pro Asn Gly Glu Ala Glu Gly Pro Asp Gly Glu Ala Ala Glu Pro
                 965                 970                 975    
 Ile Gly Glu Ala Gly Gln Pro Asn Gly Glu Ala Glu Gln Pro Asn Gly
             980                 985                 990        
 Asp Ala Asp Glu Pro Asp Gly Ala Gly Ile Glu Asp Pro Glu Glu Arg
         995                1000                1005            
 Ala Glu Glu Pro Glu Gly Lys Ala Glu Glu Pro Glu Gly Asp Ala Asp
    1010                1015                1020                
 Glu Pro Asp Gly Val Gly Ile Glu Asp Pro Glu Glu Gly Glu Asp Gln
1025                1030                1035                1040
 Glu Ile Gln Val Glu Glu Pro Tyr Tyr Asp Cys His Glu Cys Thr Glu
                1045                1050                1055    
 Thr Phe Thr Ser Ser Thr Ala Phe Ser Glu His Leu Lys Thr His Ala
            1060                1065                1070        
 Ser Met Ile Ile Phe Glu Pro Ala Asn Ala Phe Gly Glu Cys Ser Gly
        1075                1080                1085            
 Tyr Ile Glu Arg Ala Ser Thr Ser Thr Gly Gly Ala Asn Gln Ala Asp
    1090                1095                1100                
 Glu Lys Tyr Phe Lys Cys Asp Val Cys Gly Gln Leu Phe Asn Asp His
1105                1110                1115                1120
 Leu Ser Leu Ala Arg His Gln Asn Thr His Thr Gly
                1125                1130        



      <210> 1798
      <211> 79
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(79)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1798
 Val Pro Asp Asn Gly Asp Val Thr Lys Leu Pro Val Cys Ser Thr Leu
   1               5                  10                  15    
 Val Glu Glu Thr Ser Leu Thr Val Ser Glu Ala Met Glu Gln Ser Ile
              20                  25                  30        
 Lys Asn Glu Ser Pro Leu Pro Gly Thr Leu Ala His Thr Cys Asn Thr
          35                  40                  45            
 Ser Thr Leu Gly Gly Arg Gly Arg Trp Ile Thr Xaa Gly Arg Glu Phe
      50                  55                  60                
 Asp Thr Ser Met Ala Asn Met Val Lys Pro Cys Leu Tyr Arg Lys
  65                  70                  75                



      <210> 1799
      <211> 157
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(157)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1799
 Met Ser Ile Ser Pro Val Arg Trp Asn Ser Lys Glu Ala Gly Arg Ala
   1               5                  10                  15    
 Ala Asn Arg Gln Phe Pro Ser Phe Ser Pro Trp Lys Asp Asp Ser Arg
              20                  25                  30        
 Asp Ala Ser Pro Pro Glu Pro Ala Ser Pro Thr Ile Gly Pro Ile Arg
          35                  40                  45            
 Arg Leu Ala Glu Ser Ser Trp Thr Trp Gly Ser Pro Cys Ala Glu His
      50                  55                  60                
 Pro Arg Ala Arg Ala Gly Arg Arg Lys Ala Ala Thr Asp Cys Pro Trp
  65                  70                  75                  80
 Ala Ala Gly Ser Gln Trp Arg Gly Pro Ala Gly Gln Gly Ala Pro Arg
                  85                  90                  95    
 Ser Cys Leu Phe Pro Gly Ser Arg Thr Ala Ala Arg Ala Gln His Pro
             100                 105                 110        
 Arg Val Ala Pro Pro Pro Pro Pro Ala Pro Leu Asn Thr Arg Ala Ser
         115                 120                 125            
 Ala Leu Arg Ser Gln Leu Pro Arg Asn Pro Leu Xaa Val Met Thr Pro
     130                 135                 140                
 Arg Pro Pro Ala Ala Ala Pro Arg Ser Pro Val Gly Pro
 145                 150                 155        



      <210> 1800
      <211> 614
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(614)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1800
 Tyr Ser Pro Arg Pro Arg Arg Arg Arg Lys Gly Arg Arg Ala Arg Arg
   1               5                  10                  15    
 Glu Val Gln Glu Gly Pro Ser Pro Trp Val His Gly Pro Arg Val Ala
              20                  25                  30        
 Glu Asp Thr Gly Leu Val Pro Asn Trp Leu Leu Leu Leu Pro Val Ala
          35                  40                  45            
 Ser Met Ala Glu Asp Trp Leu Asp Cys Pro Ala Leu Gly Pro Gly Trp
      50                  55                  60                
 Lys Arg Arg Glu Val Phe Arg Lys Ser Gly Ala Thr Cys Gly Arg Ser
  65                  70                  75                  80
 Asp Thr Tyr Tyr Gln Ser Pro Thr Gly Asp Arg Ile Arg Ser Lys Val
                  85                  90                  95    
 Glu Leu Thr Arg Tyr Leu Gly Pro Ala Cys Asp Leu Thr Leu Phe Asp
             100                 105                 110        
 Phe Lys Gln Gly Ile Leu Cys Tyr Pro Ala Pro Lys Ala His Pro Val
         115                 120                 125            
 Ala Val Ala Ser Lys Lys Arg Lys Lys Pro Ser Arg Pro Ala Lys Thr
     130                 135                 140                
 Arg Lys Arg Gln Val Gly Pro Gln Ser Gly Glu Val Arg Lys Glu Ala
 145                 150                 155                 160
 Pro Arg Asp Glu Thr Lys Ala Asp Thr Asp Thr Ala Pro Ala Ser Phe
                 165                 170                 175    
 Pro Ala Pro Gly Cys Cys Glu Asn Cys Gly Ile Ser Phe Ser Gly Asp
             180                 185                 190        
 Gly Thr Gln Arg Gln Arg Leu Lys Thr Leu Cys Lys Asp Cys Arg Ala
         195                 200                 205            
 Gln Arg Ile Ala Phe Asn Arg Glu Gln Arg Met Phe Lys Ser Arg Gly
     210                 215                 220                
 Cys Gly Val Cys Arg Gly Cys Gln Thr Gln Glu Asp Cys Gly His Cys
 225                 230                 235                 240
 Pro Ile Cys Leu Arg Pro Pro Arg Pro Gly Leu Arg Arg Gln Trp Lys
                 245                 250                 255    
 Cys Val Gln Arg Arg Cys Leu Arg Gly Lys His Ala Arg Arg Lys Gly
             260                 265                 270        
 Gly Cys Asp Ser Lys Met Ala Ala Arg Arg Arg Pro Gly Ala Gln Pro
         275                 280                 285            
 Leu Pro Pro Pro Pro Pro Ser Gln Ser Pro Glu Pro Thr Glu Pro His
     290                 295                 300                
 Pro Arg Ala Leu Ala Pro Ser Pro Pro Ala Glu Phe Ile Tyr Tyr Cys
 305                 310                 315                 320
 Val Asp Glu Asp Glu Leu Gln Pro Tyr Thr Asn Arg Arg Gln Asn Arg
                 325                 330                 335    
 Lys Cys Gly Ala Cys Ala Ala Cys Leu Arg Arg Asn Gly Cys Gly Arg
             340                 345                 350        
 Cys Asp Phe Cys Cys Asp Lys Pro Lys Phe Gly Gly Ser Asn Gln Lys
         355                 360                 365            
 Arg Gln Lys Cys Arg Trp Arg Gln Cys Leu Gln Phe Ala Met Lys Arg
     370                 375                 380                
 Leu Leu Pro Ser Val Trp Ser Glu Ser Glu Asp Gly Ala Gly Ser Pro
 385                 390                 395                 400
 Pro Pro Tyr Arg Arg Arg Lys Arg Pro Ser Ser Ala Arg Arg His His
                 405                 410                 415    
 Leu Gly Pro Thr Leu Lys Pro Thr Leu Ala Thr Arg Thr Ala Gln Pro
             420                 425                 430        
 Asp His Thr Gln Ala Pro Thr Lys Gln Glu Ala Gly Gly Gly Phe Val
         435                 440                 445            
 Leu Pro Pro Pro Gly His Xaa Thr Leu Cys Phe Leu Arg Glu Gly Ala
     450                 455                 460                
 Ser Ser Pro Val Gln Val Pro Gly Pro Val Ala Ala Ser Thr Glu Ala
 465                 470                 475                 480
 Leu Leu Gln Glu Ala Gln Cys Ser Gly Met Ser Trp Val Val Ala Leu
                 485                 490                 495    
 Pro Gln Val Lys Gln Glu Lys Ala Asp Thr Gln Asp Glu Trp Thr Pro
             500                 505                 510        
 Gly Thr Ala Val Leu Thr Ser Pro Val Leu Val Pro Gly Cys Pro Ser
         515                 520                 525            
 Lys Ala Val Asp Pro Gly Leu Pro Ser Val Lys Gln Glu Pro Pro Asp
     530                 535                 540                
 Pro Glu Glu Asp Lys Glu Glu Asn Lys Asp Asp Ser Ala Ser Lys Leu
 545                 550                 555                 560
 Ala Pro Glu Glu Glu Ala Gly Gly Ala Gly Thr Pro Val Ile Thr Glu
                 565                 570                 575    
 Ile Phe Ser Leu Gly Gly Thr Arg Phe Arg Asp Thr Ala Val Trp Leu
             580                 585                 590        
 Pro Arg Ser Lys Asp Leu Lys Lys Pro Gly Ala Arg Lys Gln Leu Thr
         595                 600                 605            
 Gly Gly Phe Tyr Arg Leu
     610                



      <210> 1801
      <211> 143
      <212> PRT
      <213> Homo sapiens


      <400> 1801
 Ile Arg Leu Ile Thr Gln Lys Pro His Arg Phe Cys Phe Leu Gln Glu
   1               5                  10                  15    
 Asn Cys Phe Pro Ser Leu Ile Phe Thr Ile Leu Phe Ser Gln Pro Val
              20                  25                  30        
 Ser Leu Ala Gln Ile Arg Val Gln Leu Gln Pro Lys Pro Lys Ile Lys
          35                  40                  45            
 Cys Pro Ser Thr Arg Gln Gly His Thr Arg Leu Gln Ile His Arg Pro
      50                  55                  60                
 Arg Pro Pro Pro Leu His Ser Leu Gly Ala Ser Arg Gln Arg Ser Gln
  65                  70                  75                  80
 Gly Arg Cys Ser Pro Pro Arg Pro Ser Gly Pro Gly Leu His Ser Pro
                  85                  90                  95    
 His Pro Gly Pro Thr Ala Pro Glu Gly Cys Pro Gly Ala Pro Gly Ser
             100                 105                 110        
 Gln Ala Gln Gly Pro Leu Gly Ser Leu Ala Leu Gln His Pro Val Asp
         115                 120                 125            
 Cys Ser Gln Leu Gly Pro Met Gln Gly His Cys Leu Leu Asp Pro
     130                 135                 140            



      <210> 1802
      <211> 45
      <212> PRT
      <213> Homo sapiens


      <400> 1802
 Met Cys Cys Trp Ile Trp Phe Ala Ser Ile Leu Leu Arg Ile Phe Ala
   1               5                  10                  15    
 Leu Met Phe Ile Arg Asp Ile Gly Leu Lys Phe Ser Phe Phe Val Val
              20                  25                  30        
 Ser Leu Pro Gly Phe Gly Ile Arg Met Met Leu Ala Ser
          35                  40                  45



      <210> 1803
      <211> 138
      <212> PRT
      <213> Homo sapiens


      <400> 1803
 Asn Leu Asp Cys Gly Leu Ser Tyr Arg Val Ile Ser Tyr Leu Lys Lys
   1               5                  10                  15    
 Leu Ser Gln Gln Thr Lys Leu Glu Ser Glu Arg Ile Leu Ala Ser Val
              20                  25                  30        
 Gly Lys Lys Pro Pro Gln Glu Ile Gly Ile Lys Val Lys Asn His Ser
          35                  40                  45            
 Gly Gly Gly Met Ser Leu Thr His Asn Lys Asn Phe Arg Lys Leu Leu
      50                  55                  60                
 Lys Glu Ile Thr Gly Glu Thr Ala Leu Arg Leu Thr Glu Leu Asn Thr
  65                  70                  75                  80
 Lys Glu Phe Ala Gly Phe Gln Ile Gly Leu Leu Asn Lys Asp Leu Lys
                  85                  90                  95    
 Pro Gln Thr Tyr Arg Asn Ala Tyr Asp Ile Pro Arg Arg Gly Leu Leu
             100                 105                 110        
 Asp Gln Leu Thr Arg Met Arg Ser Asn Leu Leu Lys Thr His Lys Phe
         115                 120                 125            
 Ile Val Gly Gln Asp Glu Asp Ser Leu His
     130                 135            



      <210> 1804
      <211> 545
      <212> PRT
      <213> Homo sapiens


      <400> 1804
 Lys Leu Gly Pro Gly Thr Gly Thr Thr Asp Asn Ala Ala Asn Gly Val
   1               5                  10                  15    
 Thr Arg Gly Ala Pro Leu Pro Asn Arg Lys Ala Trp Leu Arg Glu Thr
              20                  25                  30        
 Arg Trp Glu Pro Pro Pro Thr Pro Gly Asp Ser Leu Ala Gly Arg Gly
          35                  40                  45            
 Arg Ala Ser Pro Ser Ala Glu Ser Ile Leu Thr Arg Ser Val Pro Arg
      50                  55                  60                
 Ala Ser Tyr Gly Asp Asp Leu Arg Glu His Ala Gly Ser Gly Arg Thr
  65                  70                  75                  80
 Leu Lys Pro Arg Arg Ala Met Glu Thr Tyr Ala Glu Val Gly Lys Glu
                  85                  90                  95    
 Gly Lys Pro Ser Cys Ala Ser Val Asp Leu Gln Gly Asp Ser Ser Leu
             100                 105                 110        
 Gln Val Glu Ile Ser Asp Ala Val Ser Glu Arg Asp Lys Val Lys Phe
         115                 120                 125            
 Thr Val Gln Thr Lys Ser Cys Leu Pro His Phe Ala Gln Thr Glu Phe
     130                 135                 140                
 Ser Val Val Arg Gln His Glu Glu Phe Ile Trp Leu His Asp Ala Tyr
 145                 150                 155                 160
 Val Glu Asn Glu Glu Tyr Ala Gly Leu Ile Ile Pro Pro Ala Pro Pro
                 165                 170                 175    
 Arg Pro Asp Phe Glu Ala Ser Arg Glu Lys Leu Gln Lys Leu Gly Glu
             180                 185                 190        
 Gly Asp Ser Ser Val Thr Arg Glu Glu Phe Ala Lys Met Lys Gln Glu
         195                 200                 205            
 Leu Glu Ala Gln Tyr Leu Ala Ile Phe Lys Lys Thr Val Ala Met His
     210                 215                 220                
 Glu Val Phe Leu Gln Arg Leu Ala Ala His Pro Thr Leu Arg Arg Asp
 225                 230                 235                 240
 His Asn Phe Phe Val Phe Leu Glu Tyr Gly Gln Asp Leu Ser Val Arg
                 245                 250                 255    
 Gly Lys Asn Arg Lys Glu Leu Leu Gly Gly Phe Leu Arg Asp Ile Val
             260                 265                 270        
 Arg Ser Ser Ala Asp Glu Ala Leu Ile Thr Gly Met Ser Gly Leu Lys
         275                 280                 285            
 Glu Val Asp Asp Phe Phe Glu His Glu Arg Thr Asn Leu Leu Glu Tyr
     290                 295                 300                
 His Thr Arg Ile Arg Asp Ala Cys Leu Arg Pro Thr Arg His Ala Ala
 305                 310                 315                 320
 His Lys Cys Thr Gln Gly Pro Arg Gly Pro Gly Ser Pro Cys Pro Ser
                 325                 330                 335    
 Pro Gln Arg Phe Asn Ser Leu Gly Glu Arg Arg Glu Gln Gly Gln Pro
             340                 345                 350        
 Cys Cys Leu Ser Arg Gly His Lys His Gln Gly Leu Thr Cys Arg Cys
         355                 360                 365            
 Arg Gly Ser Asp Gly Gly Cys Ser Pro Thr Gly Leu Ala Asp Asp Tyr
     370                 375                 380                
 Ile Pro Ile Ser Ala Ala Leu Ser Ser Leu Gly Thr Gln Glu Val Asn
 385                 390                 395                 400
 Gln Leu Arg Thr Ser Phe Leu Lys Leu Ala Glu Leu Phe Glu Arg Leu
                 405                 410                 415    
 Arg Lys Leu Glu Gly Arg Val Ala Ser Asp Glu Asp Leu Lys Leu Ser
             420                 425                 430        
 Asp Met Leu Arg Tyr Tyr Met Arg Asp Ser Gln Ala Ala Lys Asp Leu
         435                 440                 445            
 Leu Tyr Arg Arg Leu Arg Ala Leu Ala Asp Tyr Glu Asn Ala Asn Lys
     450                 455                 460                
 Ala Leu Asp Lys Ala Arg Thr Arg Asn Arg Glu Val Arg Pro Ala Glu
 465                 470                 475                 480
 Ser His Gln Gln Leu Cys Cys Gln Arg Phe Glu Arg Leu Ser Asp Ser
                 485                 490                 495    
 Ala Lys Gln Glu Leu Met Asp Phe Lys Ser Arg Arg Val Ser Ser Phe
             500                 505                 510        
 Arg Lys Asn Leu Ile Glu Leu Ala Glu Leu Glu Leu Lys His Ala Lys
         515                 520                 525            
 Ala Ser Thr Leu Ile Leu Arg Asn Thr Leu Val Ala Leu Lys Gly Glu
     530                 535                 540                
 Pro
 545



      <210> 1805
      <211> 125
      <212> PRT
      <213> Homo sapiens


      <400> 1805
 Gly Gly Glu Thr Met Ser Lys Leu Ser Phe Arg Ala Arg Ala Leu Asp
   1               5                  10                  15    
 Ala Ala Lys Pro Leu Pro Ile Tyr Arg Gly Lys Asp Met Pro Asp Leu
              20                  25                  30        
 Asn Asp Cys Val Ser Ile Asn Arg Ala Val Pro Gln Met Pro Thr Gly
          35                  40                  45            
 Met Glu Lys Glu Glu Glu Ser Glu His His Leu Gln Arg Ala Ile Ser
      50                  55                  60                
 Ala Gln Gln Val Phe Arg Glu Lys Lys Glu Ser Met Val Ile Pro Val
  65                  70                  75                  80
 Pro Glu Ala Glu Ser Asn Val Asn Tyr Tyr Asn Arg Leu Tyr Lys Gly
                  85                  90                  95    
 Glu Phe Lys Gln Pro Lys Gln Phe Ile His Ile Gln Leu Lys Leu His
             100                 105                 110        
 Leu Lys Leu Leu Leu Phe Arg Ile Glu Val Leu Phe Phe
         115                 120                 125



      <210> 1806
      <211> 249
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(249)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1806
 Ala Ser Phe Leu Leu Gln Met Cys Pro Xaa Gly Pro Val Gln Ser Leu
   1               5                  10                  15    
 Ser Ser Glu Pro Xaa Gly Ser Gly Gly Phe Cys Leu Pro Leu Lys Ser
              20                  25                  30        
 Ala Gln Gly Thr Xaa Thr Pro Gln Asp Thr Cys Arg Gln Gly His Pro
          35                  40                  45            
 Gly Ile Pro Gly Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly
      50                  55                  60                
 Arg Asp Gly Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg
  65                  70                  75                  80
 Pro Gly Ser Pro Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg
                  85                  90                  95    
 Gly Ala Asp Gly Lys Val Glu Ala Lys Gly Ile Lys Gly Asp Gln Gly
             100                 105                 110        
 Ser Xaa Gly Ser Pro Gly Lys His Gly Pro Lys Gly Leu Ala Gly Pro
         115                 120                 125            
 Met Gly Glu Lys Gly Leu Arg Gly Glu Thr Gly Pro Gln Gly Gln Lys
     130                 135                 140                
 Gly Asn Lys Gly Asp Val Gly Pro Thr Gly Pro Glu Gly Pro Arg Gly
 145                 150                 155                 160
 Asn Ile Gly Pro Leu Gly Pro Thr Gly Leu Pro Gly Pro Met Gly Pro
                 165                 170                 175    
 Ile Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly Pro Gln
             180                 185                 190        
 Gly Glu Pro Gly Val Arg Gly Ile Arg Gly Trp Lys Gly Asp Arg Gly
         195                 200                 205            
 Glu Lys Gly Lys Ile Gly Glu Thr Leu Val Leu Pro Lys Ser Ala Phe
     210                 215                 220                
 Thr Val Gly Leu Thr Val Leu Ser Lys Phe Pro Ser Ser Asp Val Pro
 225                 230                 235                 240
 Ile Lys Phe Asp Lys Ile His Ile Thr
                 245                



      <210> 1807
      <211> 105
      <212> PRT
      <213> Homo sapiens


      <400> 1807
 Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser Arg Asp Ser Gln Gly
   1               5                  10                  15    
 His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala
              20                  25                  30        
 Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly Arg Met Asn Gln Gly
          35                  40                  45            
 Thr Ala Arg Leu Ala Ser Leu Met Asn Leu Gly Met Ser Ser Ser Leu
      50                  55                  60                
 Asn Gln Gln Gly Ala His Ser Ala Leu Ser Ser Ala Ser Thr Ser Ser
  65                  70                  75                  80
 His Asn Cys Ser Leu Tyr Leu Thr Leu Glu Glu Arg Ser Thr Pro Phe
                  85                  90                  95    
 Ile Phe Ser Thr Pro Trp Arg Cys Arg
             100                 105



      <210> 1808
      <211> 272
      <212> PRT
      <213> Homo sapiens


      <400> 1808
 Arg Ile Ile Gly Tyr Arg Ser Gly Ile Ser Gly Ser Thr Ile Ser Ser
   1               5                  10                  15    
 Glu Leu Glu Tyr Glu Ser Val Leu Cys Val Lys Pro Asp Val Ser Val
              20                  25                  30        
 Tyr Arg Ile Pro Pro Arg Ala Ser Asn Arg Gly Tyr Arg Ala Ser Asp
          35                  40                  45            
 Trp Lys Leu Asp Gln Pro Asp Trp Thr Gly Arg Leu Arg Ile Thr Ser
      50                  55                  60                
 Lys Gly Lys Thr Ala Tyr Ile Lys Leu Glu Asp Lys Val Ser Gly Glu
  65                  70                  75                  80
 Leu Phe Ala Gln Ala Pro Val Glu Gln Tyr Pro Gly Ile Ala Val Glu
                  85                  90                  95    
 Thr Val Thr Asp Ser Ser Arg Tyr Phe Val Ile Arg Ile Gln Asp Gly
             100                 105                 110        
 Thr Gly Arg Ser Ala Phe Ile Gly Ile Gly Phe Thr Asp Arg Gly Asp
         115                 120                 125            
 Ala Phe Asp Phe Asn Val Ser Leu Gln Asp His Phe Lys Trp Val Lys
     130                 135                 140                
 Gln Glu Ser Glu Ile Ser Lys Glu Ser Gln Glu Met Asp Ala Arg Pro
 145                 150                 155                 160
 Lys Leu Asp Leu Gly Phe Lys Glu Gly Gln Thr Ile Lys Leu Cys Ile
                 165                 170                 175    
 Gly Asn Ile Thr Asn Lys Lys Gly Gly Ala Ser Lys Pro Arg Thr Ala
             180                 185                 190        
 Arg Gly Gly Gly Leu Ser Leu Leu Pro Pro Pro Pro Gly Gly Lys Val
         195                 200                 205            
 Thr Ile Pro Pro Pro Ser Ser Ser Val Ala Ile Ser Asn His Val Thr
     210                 215                 220                
 Pro Pro Pro Ile Pro Lys Ser Asn His Gly Gly Ser Asp Ala Asp Ile
 225                 230                 235                 240
 Leu Leu Asp Leu Asp Ser Pro Ala Pro Val Thr Thr Pro Ala Pro Leu
                 245                 250                 255    
 Tyr Cys Gly Arg Ser Gly Gly Ser Thr Leu Thr Tyr Ala Gly Val Thr
             260                 265                 270        





      <210> 1809
      <211> 107
      <212> PRT
      <213> Homo sapiens


      <400> 1809
 Arg Ser His Arg Gly Glu Leu Ile Pro Lys Asp Ser Cys Tyr Met Arg
   1               5                  10                  15    
 Lys Pro Pro Arg Arg Pro Lys Lys Arg Arg Gln Gly Cys Ala Leu Pro
              20                  25                  30        
 Gln Gly Cys Leu Thr Phe Lys Asp Val Ala Ile Glu Phe Ser Leu Glu
          35                  40                  45            
 Glu Trp Lys Cys Leu Asn Pro Ala Gln Arg Ala Leu Tyr Arg Ala Val
      50                  55                  60                
 Met Leu Glu Asn Tyr Arg Asn Leu Glu Ser Val Gly Leu Thr Ser Lys
  65                  70                  75                  80
 Asp Ser Trp Tyr Met Arg Lys Lys Pro Gly Arg Gly Arg Gly Lys Gln
                  85                  90                  95    
 Arg Arg Gln Glu Trp Phe Phe Leu Arg Val Tyr
             100                 105        



      <210> 1810
      <211> 113
      <212> PRT
      <213> Homo sapiens


      <400> 1810
 Val Trp Leu Arg Gly Arg Ala His Pro Leu Pro Val Pro Gly Ala Gly
   1               5                  10                  15    
 Thr Trp Pro Arg Gly Gly Arg Gly Leu Gly Glu Thr Ala Cys Arg Pro
              20                  25                  30        
 Ser Thr Val Gly His Arg Arg Pro Val Phe Leu Phe Thr Val Gly Ser
          35                  40                  45            
 Arg Gly Met Ala Ala Gln Leu Leu Thr Asp Glu Ala Leu Glu Ser Val
      50                  55                  60                
 Thr Phe Arg Asp Val Thr Val Asp Phe Thr Gln Glu Glu Trp Gln Gln
  65                  70                  75                  80
 Leu Glu Pro Ala Gln Lys Asp Leu Tyr Arg Asp Val Met Leu Glu Asn
                  85                  90                  95    
 Tyr Arg Asn Leu Val Ser Leu Ala Phe Leu Glu Val Leu Leu Thr Cys
             100                 105                 110        
 Asn
    



      <210> 1811
      <211> 378
      <212> PRT
      <213> Homo sapiens


      <400> 1811
 Ala Ala Ala Ser Val Arg Gln Ser Pro Gly Pro Ala Leu Ala Arg Leu
   1               5                  10                  15    
 Glu Gly Arg Glu Phe Glu Phe Leu Met Arg Gln Pro Ser Val Thr Ile
              20                  25                  30        
 Gly Arg Asn Ser Ser Gln Gly Ser Val Asp Leu Ser Met Gly Leu Ser
          35                  40                  45            
 Ser Phe Ile Ser Arg Arg His Leu Gln Leu Ser Phe Gln Glu Pro His
      50                  55                  60                
 Phe Tyr Leu Arg Cys Leu Gly Lys Asn Gly Val Phe Val Asp Gly Ala
  65                  70                  75                  80
 Phe Gln Arg Arg Gly Ala Pro Ala Leu Gln Leu Pro Lys Gln Cys Thr
                  85                  90                  95    
 Phe Arg Phe Pro Ser Thr Ala Ile Lys Ile Gln Phe Thr Ser Leu Tyr
             100                 105                 110        
 His Lys Glu Glu Ala Pro Ala Ser Pro Leu Arg Pro Leu Tyr Pro Gln
         115                 120                 125            
 Ile Ser Pro Leu Lys Ile His Ile Pro Glu Pro Asp Leu Arg Ser Met
     130                 135                 140                
 Val Ser Pro Val Pro Ser Pro Thr Gly Thr Ile Ser Val Pro Asn Ser
 145                 150                 155                 160
 Cys Pro Ala Ser Pro Arg Gly Ala Gly Ser Ser Ser Tyr Arg Phe Val
                 165                 170                 175    
 Gln Asn Val Thr Ser Asp Leu Gln Leu Ala Ala Glu Phe Ala Ala Lys
             180                 185                 190        
 Ala Ala Ser Glu Gln Gln Ala Asp Thr Ser Gly Gly Asp Ser Pro Lys
         195                 200                 205            
 Asp Glu Ser Lys Pro Pro Phe Ser Tyr Ala Gln Leu Ile Val Gln Ala
     210                 215                 220                
 Ile Ser Ser Ala Gln Asp Arg Gln Leu Thr Leu Ser Gly Ile Tyr Ala
 225                 230                 235                 240
 His Ile Thr Lys His Tyr Pro Tyr Tyr Arg Thr Ala Asp Lys Gly Trp
                 245                 250                 255    
 Gln Asn Ser Ile Arg His Asn Leu Ser Leu Asn Arg Tyr Phe Ile Lys
             260                 265                 270        
 Val Pro Arg Ser Gln Glu Glu Pro Gly Lys Gly Ser Phe Trp Arg Ile
         275                 280                 285            
 Asp Pro Ala Ser Glu Ala Lys Leu Val Glu Gln Ala Phe Arg Lys Arg
     290                 295                 300                
 Arg Gln Arg Gly Val Ser Cys Phe Arg Thr Pro Phe Gly Pro Leu Ser
 305                 310                 315                 320
 Ser Arg Ser Ala Pro Ala Ser Pro Thr His Pro Gly Leu Met Ser Pro
                 325                 330                 335    
 Arg Ser Gly Gly Leu Gln Thr Pro Glu Cys Leu Ser Arg Glu Gly Ser
             340                 345                 350        
 Pro Ile Pro His Asp Pro Glu Phe Gly Ser Lys Leu Ala Ser Val Pro
         355                 360                 365            
 Glu Tyr Arg Tyr Ser Gln Pro Thr Arg Pro
     370                 375            



      <210> 1812
      <211> 375
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(375)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1812
 Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys
   1               5                  10                  15    
 Val Phe Ser His Lys Ser Ser Leu Val Asn His Trp Arg Ile His Thr
              20                  25                  30        
 Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe Ser His
          35                  40                  45            
 Lys Ser Ser Leu Val Asn His Trp Arg Ile His Thr Gly Glu Lys Pro
      50                  55                  60                
 Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe Ser Arg Asn Ser Tyr Leu
  65                  70                  75                  80
 Ala Gln His Leu Ile Ile His Ala Gly Glu Lys Pro Tyr Lys Cys Asp
                  85                  90                  95    
 Glu Cys Asp Lys Ala Phe Ser Gln Asn Ser His Leu Val Gln His His
             100                 105                 110        
 Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys
         115                 120                 125            
 Val Phe Ser Gln Asn Ser Tyr Leu Ala Tyr His Trp Arg Ile His Thr
     130                 135                 140                
 Gly Glu Lys Ala Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe Gly Leu
 145                 150                 155                 160
 Asn Ser Ser Leu Ala His His Arg Lys Ile His Thr Gly Glu Lys Pro
                 165                 170                 175    
 Phe Lys Cys Asn Glu Cys Gly Lys Ala Phe Ser Met Arg Ser Ser Leu
             180                 185                 190        
 Thr Asn His His Ala Ile His Thr Gly Glu Lys His Phe Lys Cys Asn
         195                 200                 205            
 Glu Cys Gly Lys Leu Phe Arg Asp Asn Ser Tyr Leu Val Arg His Gln
     210                 215                 220                
 Arg Phe His Ala Gly Lys Lys Ser Asn Thr Cys Asn Xaa Cys Gly Arg
 225                 230                 235                 240
 Val Phe Ser Xaa His Xaa Ser Leu Val Arg His Thr Ile Ile Tyr Thr
                 245                 250                 255    
 Gly Glu Lys Leu Cys Lys Tyr Asn Glu Cys Ser Arg Ala Phe Ser Phe
             260                 265                 270        
 Cys Ser Arg Leu Asn Asn Arg Xaa Leu Asp His Arg Gly Gln Lys Leu
         275                 280                 285            
 Tyr Xaa Cys Thr Glu Cys Gly Lys Val Leu Arg Xaa Asn Leu Arg Pro
     290                 295                 300                
 Gly Phe Phe Lys Glu Phe Leu Ala Gly Glu Lys Pro Asn Lys Cys Asn
 305                 310                 315                 320
 Glu Cys Gly Lys Val Phe Ser Arg Asn Ser Tyr Leu Ala Gln His Leu
                 325                 330                 335    
 Ile Ile His Ala Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Asp Lys
             340                 345                 350        
 Ala Phe Ser Gln Asn Ser His Leu Val Gln His His Arg Ile His Thr
         355                 360                 365            
 Xaa Glu Lys Pro Tyr Lys Cys
     370                 375



      <210> 1813
      <211> 217
      <212> PRT
      <213> Homo sapiens


      <400> 1813
 Gly Arg Pro Gly Ala Gly Ala Ser Glu Leu Phe Pro Ser Val Thr Thr
   1               5                  10                  15    
 Asp Leu Ser Val Ser Lys Gln Asn Ala Cys Leu Thr Cys Val Asp Phe
              20                  25                  30        
 Val Thr Val His Val Cys Met Gly Phe Trp Gly Ile Gly Pro Gly Ala
          35                  40                  45            
 Leu Ser Thr Ser Cys Ile Pro Tyr Pro Leu Ser His Gly Pro Gly Ser
      50                  55                  60                
 Val Lys Ala Glu Met Leu His Met Tyr Ser Gln Lys Asp Pro Leu Ile
  65                  70                  75                  80
 Leu Cys Val Arg Leu Ala Val Leu Leu Ala Val Thr Leu Thr Val Pro
                  85                  90                  95    
 Val Val Leu Phe Pro Ile Arg Arg Ala Leu Gln Gln Leu Leu Phe Pro
             100                 105                 110        
 Gly Lys Ala Phe Ser Trp Pro Arg His Val Ala Ile Ala Leu Ile Leu
         115                 120                 125            
 Leu Val Leu Val Asn Val Leu Val Ile Cys Val Pro Thr Ile Arg Asp
     130                 135                 140                
 Ile Phe Gly Val Ile Gly Ser Thr Ser Ala Pro Ser Leu Ile Phe Ile
 145                 150                 155                 160
 Leu Pro Ser Ile Phe Tyr Leu Arg Ile Val Pro Ser Glu Val Glu Pro
                 165                 170                 175    
 Phe Leu Ser Trp Pro Lys Ile Gln Ala Leu Cys Phe Gly Val Leu Gly
             180                 185                 190        
 Val Leu Phe Met Ala Val Ser Leu Gly Phe Met Phe Ala Asn Trp Ala
         195                 200                 205            
 Thr Gly Gln Ser Arg Met Ser Gly His
     210                 215        



      <210> 1814
      <211> 1435
      <212> PRT
      <213> Homo sapiens


      <400> 1814
 Gly Thr His Pro Ala Ser Ser Gly Pro Val Pro Leu Pro Pro Ala Ala
   1               5                  10                  15    
 Val Ser Ala Ala Thr Arg Glu Glu Leu Gly Glu Pro Val Pro Phe Val
              20                  25                  30        
 Thr Ala Ser Ser Gly Phe Gln Ser Met His Ser Ser Asn Pro Lys Val
          35                  40                  45            
 Arg Ser Ser Pro Ser Gly Asn Thr Gln Ser Ser Pro Lys Ser Lys Gln
      50                  55                  60                
 Glu Val Met Val Arg Pro Pro Thr Val Met Ser Pro Ser Gly Asn Pro
  65                  70                  75                  80
 Gln Leu Asp Ser Lys Phe Ser Asn Gln Gly Lys Gln Gly Gly Ser Ala
                  85                  90                  95    
 Ser Gln Ser Gln Pro Ser Pro Cys Asp Ser Lys Ser Gly Gly His Thr
             100                 105                 110        
 Pro Lys Ala Leu Pro Gly Pro Gly Gly Ser Met Gly Leu Lys Asn Gly
         115                 120                 125            
 Ala Gly Asn Gly Ala Lys Gly Lys Gly Lys Arg Glu Arg Ser Ile Ser
     130                 135                 140                
 Ala Asp Ser Phe Asp Gln Arg Asp Pro Gly Thr Pro Asn Asp Asp Ser
 145                 150                 155                 160
 Asp Ile Lys Glu Cys Asn Ser Ala Asp His Ile Lys Ser Gln Asp Ser
                 165                 170                 175    
 Gln His Thr Pro His Ser Met Thr Pro Ser Asn Ala Thr Ala Pro Arg
             180                 185                 190        
 Ser Ser Thr Pro Pro His Gly Gln Thr Thr Ala Thr Glu Pro Thr Pro
         195                 200                 205            
 Ala Gln Lys Thr Pro Ala Lys Val Val Tyr Val Phe Ser Thr Glu Met
     210                 215                 220                
 Ala Asn Lys Ala Ala Glu Ala Val Leu Lys Gly Gln Val Glu Thr Ile
 225                 230                 235                 240
 Val Ser Phe His Ile Gln Asn Ile Ser Asn Asn Lys Thr Glu Arg Ser
                 245                 250                 255    
 Thr Ala Pro Leu Asn Thr Gln Ile Ser Ala Leu Arg Asn Asp Pro Lys
             260                 265                 270        
 Pro Leu Pro Gln Gln Pro Pro Ala Pro Ala Asn Gln Asp Gln Asn Ser
         275                 280                 285            
 Ser Gln Asn Thr Arg Leu Gln Pro Thr Pro Pro Ile Pro Ala Pro Ala
     290                 295                 300                
 Pro Lys Pro Ala Ala Pro Pro Arg Pro Leu Asp Arg Glu Ser Pro Gly
 305                 310                 315                 320
 Val Glu Asn Lys Leu Ile Pro Ser Val Gly Ser Pro Ala Ser Ser Thr
                 325                 330                 335    
 Pro Leu Pro Pro Asp Gly Thr Gly Pro Asn Ser Thr Pro Asn Asn Arg
             340                 345                 350        
 Ala Val Thr Pro Val Ser Gln Gly Ser Asn Ser Ser Ser Ala Asp Pro
         355                 360                 365            
 Lys Ala Pro Pro Pro Pro Pro Val Ser Ser Gly Glu Pro Pro Thr Leu
     370                 375                 380                
 Gly Glu Asn Pro Asp Gly Leu Ser Gln Glu Gln Leu Glu His Arg Glu
 385                 390                 395                 400
 Arg Ser Leu Gln Thr Leu Arg Asp Ile Gln Arg Met Leu Phe Pro Asp
                 405                 410                 415    
 Glu Lys Glu Phe Thr Gly Ala Gln Ser Gly Gly Pro Gln Gln Asn Pro
             420                 425                 430        
 Gly Val Leu Asp Gly Pro Gln Lys Lys Pro Glu Gly Pro Ile Gln Ala
         435                 440                 445            
 Met Met Ala Gln Ser Gln Ser Leu Gly Lys Gly Pro Gly Pro Arg Thr
     450                 455                 460                
 Asp Val Gly Ala Pro Phe Gly Pro Gln Gly His Arg Asp Val Pro Phe
 465                 470                 475                 480
 Ser Pro Asp Glu Met Val Pro Pro Ser Met Asn Ser Gln Ser Gly Thr
                 485                 490                 495    
 Ile Gly Pro Asp His Leu Asp His Met Thr Pro Glu Gln Ile Ala Trp
             500                 505                 510        
 Leu Lys Leu Gln Gln Glu Phe Tyr Glu Glu Lys Arg Arg Lys Pro Glu
         515                 520                 525            
 Gln Val Val Val Gln Gln Cys Ser Leu Gln Asp Met Met Val His Gln
     530                 535                 540                
 His Gly Pro Arg Gly Val Val Arg Gly Pro Pro Pro Pro Tyr Gln Met
 545                 550                 555                 560
 Thr Pro Ser Glu Gly Trp Ala Pro Gly Gly Thr Glu Pro Phe Ser Asp
                 565                 570                 575    
 Gly Ile Asn Met Pro His Ser Leu Pro Pro Arg Gly Met Ala Pro His
             580                 585                 590        
 Pro Asn Met Pro Gly Ser Gln Met Arg Leu Pro Gly Phe Ala Gly Met
         595                 600                 605            
 Ile Asn Ser Glu Met Glu Gly Pro Asn Val Pro Asn Pro Ala Ser Arg
     610                 615                 620                
 Pro Gly Leu Ser Gly Val Ser Trp Pro Asp Asp Val Pro Lys Ile Pro
 625                 630                 635                 640
 Asp Gly Arg Asn Phe Pro Pro Gly Gln Gly Ile Phe Ser Gly Pro Gly
                 645                 650                 655    
 Arg Gly Glu Arg Phe Pro Asn Pro Gln Gly Leu Ser Glu Glu Met Phe
             660                 665                 670        
 Gln Gln Gln Leu Ala Glu Lys Gln Leu Gly Leu Pro Pro Gly Met Ala
         675                 680                 685            
 Met Glu Gly Ile Arg Pro Ser Met Glu Met Asn Arg Met Ile Pro Gly
     690                 695                 700                
 Ser Gln Arg His Met Glu Pro Gly Asn Asn Pro Ile Phe Pro Arg Ile
 705                 710                 715                 720
 Pro Val Glu Gly Pro Leu Ser Pro Ser Arg Gly Asp Phe Pro Lys Gly
                 725                 730                 735    
 Ile Pro Pro Gln Met Gly Pro Gly Arg Glu Leu Glu Phe Gly Met Val
             740                 745                 750        
 Pro Ser Gly Met Lys Gly Asp Val Asn Leu Asn Val Asn Met Gly Ser
         755                 760                 765            
 Asn Ser Gln Met Ile Pro Gln Lys Met Arg Glu Ala Gly Ala Gly Pro
     770                 775                 780                
 Glu Glu Met Leu Lys Leu Arg Pro Gly Gly Ser Asp Met Leu Pro Ala
 785                 790                 795                 800
 Gln Gln Lys Met Val Pro Leu Pro Phe Gly Glu His Pro Gln Gln Glu
                 805                 810                 815    
 Tyr Gly Met Gly Pro Arg Pro Phe Leu Pro Met Ser Gln Gly Pro Gly
             820                 825                 830        
 Ser Asn Ser Gly Leu Arg Asn Leu Arg Glu Pro Ile Gly Pro Asp Gln
         835                 840                 845            
 Arg Thr Asn Ser Arg Leu Ser His Met Pro Pro Leu Pro Leu Asn Pro
     850                 855                 860                
 Ser Ser Asn Pro Thr Ser Leu Asn Thr Ala Pro Pro Val Gln Arg Gly
 865                 870                 875                 880
 Leu Gly Arg Lys Pro Leu Asp Ile Ser Val Ala Gly Ser Gln Val His
                 885                 890                 895    
 Ser Pro Gly Ile Asn Pro Leu Lys Ser Pro Thr Met His Gln Val Gln
             900                 905                 910        
 Ser Pro Met Leu Gly Ser Pro Ser Gly Asn Leu Lys Ser Pro Gln Thr
         915                 920                 925            
 Pro Ser Gln Leu Ala Gly Met Leu Ala Gly Pro Ala Ala Ala Ala Ser
     930                 935                 940                
 Ile Lys Ser Pro Pro Val Leu Gly Ser Ala Ala Ala Ser Pro Val His
 945                 950                 955                 960
 Leu Lys Ser Pro Ser Leu Pro Ala Pro Ser Pro Gly Trp Thr Ser Ser
                 965                 970                 975    
 Pro Glu Pro Pro Leu Gln Ser Pro Gly Ile Pro Pro Asn His Lys Ala
             980                 985                 990        
 Pro Leu Thr Met Ala Ser Pro Ala Met Leu Gly Asn Val Glu Ser Gly
         995                1000                1005            
 Gly Pro Pro Pro Pro Thr Ala Ser Gln Pro Ala Ser Val Asn Ile Pro
    1010                1015                1020                
 Gly Ser Leu Pro Ser Ser Thr Pro Tyr Thr Met Pro Pro Glu Pro Thr
1025                1030                1035                1040
 Leu Ser Gln Asn Pro Leu Ser Ile Met Met Ser Arg Met Ser Lys Phe
                1045                1050                1055    
 Ala Met Pro Ser Ser Asn Pro Gly Tyr Asn His Asp Ala Ile Lys Thr
            1060                1065                1070        
 Val Ala Ser Ser Asp Asp Asp Ser Pro Pro Ala Arg Ser Pro Asn Leu
        1075                1080                1085            
 Pro Ser Met Asn Asn Met Pro Gly Met Gly Ile Asn Thr Gln Asn Pro
    1090                1095                1100                
 Arg Ile Ser Gly Pro Asn Pro Val Val Pro Met Pro Thr Leu Ser Pro
1105                1110                1115                1120
 Met Gly Met Thr Gln Pro Leu Ser His Ser Asn Gln Met Pro Ser Pro
                1125                1130                1135    
 Asn Ala Val Gly Pro Asn Ile Pro Pro His Gly Val Pro Met Gly Pro
            1140                1145                1150        
 Gly Leu Met Ser His Asn Pro Ile Met Gly His Gly Ser Gln Glu Pro
        1155                1160                1165            
 Pro Met Val Pro Gln Gly Arg Met Gly Phe Pro Gln Gly Phe Pro Pro
    1170                1175                1180                
 Val Gln Ser Pro Pro Gln Gln Val Pro Phe Pro His Asn Gly Pro Ser
1185                1190                1195                1200
 Gly Gly Gln Gly Ser Phe Pro Gly Gly Met Gly Phe Pro Gly Glu Gly
                1205                1210                1215    
 Pro Leu Gly Arg Pro Ser Asn Leu Pro Gln Ser Ser Ala Asp Ala Ala
            1220                1225                1230        
 Leu Cys Lys Pro Gly Gly Pro Gly Gly Pro Asp Ser Phe Thr Val Leu
        1235                1240                1245            
 Gly Asn Ser Met Pro Ser Val Phe Thr Asp Pro Asp Leu Gln Glu Val
    1250                1255                1260                
 Ile Arg Pro Gly Ala Thr Gly Ile Pro Glu Phe Asp Leu Ser Arg Ile
1265                1270                1275                1280
 Ile Pro Ser Glu Lys Pro Ser Gln Thr Leu Gln Tyr Phe Pro Arg Gly
                1285                1290                1295    
 Glu Val Pro Gly Arg Lys Gln Pro Gln Gly Pro Gly Pro Gly Phe Ser
            1300                1305                1310        
 His Met Gln Gly Met Met Gly Glu Gln Ala Pro Arg Met Gly Leu Ala
        1315                1320                1325            
 Leu Pro Gly Met Gly Gly Pro Gly Pro Val Gly Thr Pro Asp Ile Pro
    1330                1335                1340                
 Leu Gly Thr Ala Pro Ser Met Pro Gly His Asn Pro Met Arg Pro Pro
1345                1350                1355                1360
 Ala Phe Leu Gln Gln Gly Met Met Gly Pro His His Arg Met Met Ser
                1365                1370                1375    
 Pro Ala Gln Ser Thr Met Pro Gly Gln Pro Thr Leu Met Ser Asn Pro
            1380                1385                1390        
 Ala Ala Ala Val Gly Met Ile Pro Gly Lys Asp Arg Gly Pro Ala Gly
        1395                1400                1405            
 Leu Tyr Thr His Pro Gly Pro Val Gly Ser Pro Gly Met Met Met Ser
    1410                1415                1420                
 Met Gln Gly Met Met Gly Pro Asn Arg Thr Ser
1425                1430                1435



      <210> 1815
      <211> 277
      <212> PRT
      <213> Homo sapiens


      <400> 1815
 Thr Gly Val Met Pro Pro Gly Arg Trp His Ala Ala Ile Ser Ser Ser
   1               5                  10                  15    
 Gly Pro Val Phe Glu Gly Ala Arg Ala Leu Gln Thr Val Lys Lys Glu
              20                  25                  30        
 Glu Glu Asp Glu Ser Tyr Thr Pro Val Gln Ala Ala Arg Pro Gln Thr
          35                  40                  45            
 Leu Asn Arg Pro Gly Gln Glu Leu Phe Arg Gln Leu Phe Arg Gln Leu
      50                  55                  60                
 Arg Tyr His Glu Ser Ser Gly Pro Leu Glu Thr Leu Ser Arg Leu Arg
  65                  70                  75                  80
 Glu Leu Cys Arg Trp Trp Leu Arg Pro Asp Val Leu Ser Lys Ala Gln
                  85                  90                  95    
 Ile Leu Glu Leu Leu Val Leu Glu Gln Phe Leu Ser Ile Leu Pro Gly
             100                 105                 110        
 Glu Leu Arg Val Trp Val Gln Leu His Asn Pro Glu Ser Gly Glu Glu
         115                 120                 125            
 Leu Trp Pro Cys Trp Arg Ser Cys Arg Gly Thr Leu Met Gly His Pro
     130                 135                 140                
 Gly Gly Thr Arg Ala Leu Pro Glu Pro Arg Cys Ala Leu Asp Gly Tyr
 145                 150                 155                 160
 Arg Ser Leu Arg Ser Ala Gln Ile Trp Ser Leu Ala Ser Pro Leu Arg
                 165                 170                 175    
 Ser Ser Ser Ala Leu Gly Asp His Leu Glu Pro Pro Tyr Glu Ile Glu
             180                 185                 190        
 Ala Arg Asp Phe Leu Ala Gly Gln Ser Asp Thr Pro Ala Ala Gln Met
         195                 200                 205            
 Pro Ala Leu Phe Pro Arg Glu Gly Cys Pro Gly Asp Gln Val Thr Pro
     210                 215                 220                
 Thr Arg Ser Leu Thr Ala Gln Leu Gln Glu Thr Met Thr Phe Lys Asp
 225                 230                 235                 240
 Val Glu Val Thr Phe Ser Gln Asp Glu Trp Gly Trp Leu Asp Ser Ala
                 245                 250                 255    
 Gln Arg Asn Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Met
             260                 265                 270        
 Ala Ser Leu Gly Lys
         275        



      <210> 1816
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 1816
 Pro Gln Val Pro Val Arg Arg Thr Leu Leu Ser Arg Arg Trp Val Trp
   1               5                  10                  15    
 His Arg Ala Arg Val Pro Pro Pro Arg Pro Trp Val Ser Thr His Leu
              20                  25                  30        
 Ala Pro Ser Ser His Arg Met Arg Asp Ala Gly Val Leu Ser Arg Val
          35                  40                  45            
 Cys Gly Leu Leu Arg Gln Leu His Thr Ala Tyr Ser Gly Leu Val Ser
      50                  55                  60                
 Ser Leu Gln Gly Leu Pro Ala Glu Leu Gln Gln Pro Val Gly Arg Ala
  65                  70                  75                  80
 Arg His Ser Leu Cys Glu Leu Tyr Gly Ile Val Ala Ser Ala Gly Ser
                  85                  90                  95    
 Val Glu Glu Leu Pro Ala Glu Arg Leu Val Gln Ser Arg Glu Gly Val
             100                 105                 110        
 His Gln Ala Trp Gln Gly Leu Glu Gln Leu Leu Glu Gly Leu Gln His
         115                 120                 125            
 Asn Pro Pro Leu Ser Trp Leu Val Gly Pro Phe Ala Leu Pro Ala Gly
     130                 135                 140                
 Gly Gln
 145    



      <210> 1817
      <211> 97
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(97)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1817
 Pro Leu Cys Thr Val Gly Arg Asp Ile Lys Trp Cys Val Ala Gly Pro
   1               5                  10                  15    
 Cys Lys Asn Xaa Pro Gly Val Val Ala Cys Ile Cys Cys Leu Ser Leu
              20                  25                  30        
 Leu Ser Gly Trp Asp Tyr Arg His Leu Pro Pro Cys Ala Ala Asn Phe
          35                  40                  45            
 Leu Tyr Phe Xaa Xaa Arg Arg Gly Phe Thr Met Leu Asp Arg Met Val
      50                  55                  60                
 Ser Ile Ser Xaa Val Cys Asp Leu Pro Ala Leu Ala Ser Gln Ser Ala
  65                  70                  75                  80
 Gly Ile Thr Gly Val Ser His His Ala Glu Pro Tyr Ala Val Ser Arg
                  85                  90                  95    
 Ala
    



      <210> 1818
      <211> 328
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(328)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1818
 Leu Gln Gly Asp Thr Trp His Leu Ser Phe Leu Ser His Phe Ser Arg
   1               5                  10                  15    
 Leu His Gly Gly Val Pro Gly Arg Gly Leu Leu Glu Gly Asn Leu Leu
              20                  25                  30        
 Gln Pro Gln Ala Pro Gly His Asp Met Thr Ser Ile Pro Phe Pro Gly
          35                  40                  45            
 Asp Arg Leu Leu Gln Val Asp Gly Val Ile Leu Cys Gly Leu Thr His
      50                  55                  60                
 Lys Gln Ala Val Gln Cys Leu Lys Gly Pro Gly Gln Val Ala Arg Leu
  65                  70                  75                  80
 Val Leu Glu Arg Arg Val Pro Arg Ser Thr Gln Gln Cys Pro Ser Ala
                  85                  90                  95    
 Asn Asp Ser Met Gly Asp Glu Arg Thr Ala Val Ser Leu Val Thr Ala
             100                 105                 110        
 Leu Pro Gly Arg Pro Ser Ser Cys Val Ser Val Thr Asp Gly Pro Lys
         115                 120                 125            
 Phe Xaa Ser Ser Asn Xaa Lys Arg Ile Ala Asn Gly Leu Gly Phe Ser
     130                 135                 140                
 Phe Val Gln Met Glu Lys Glu Ser Cys Ser His Leu Lys Ser Asp Leu
 145                 150                 155                 160
 Val Arg Ile Lys Arg Leu Phe Pro Gly His Pro Ala Glu Glu Asn Gly
                 165                 170                 175    
 Ala Ile Ala Ala Gly Asp Ile Ile Leu Gly Arg Glu Trp Glu Gly Pro
             180                 185                 190        
 Arg Lys Ala Ser Ser Ser Arg Cys Arg Gly Ser Trp Ala Met Gln Leu
         195                 200                 205            
 Ser Val Gln Ala Gly Pro Ser Phe Ala Ser Tyr Tyr Pro Ala Ala Val
     210                 215                 220                
 Glu Val Leu His Leu Leu Arg Gly Ala Pro Gln Glu Val Thr Leu Leu
 225                 230                 235                 240
 Leu Cys Arg Pro Pro Pro Gly Ala Leu Pro Glu Leu Glu Gln Glu Trp
                 245                 250                 255    
 Gln Thr Pro Glu Leu Ser Ala Asp Lys Glu Phe Thr Arg Ala Thr Cys
             260                 265                 270        
 Thr Asp Ser Cys Thr Ser Pro Ile Leu Gly Ser Arg Gly Gln Leu Gly
         275                 280                 285            
 Gly Thr Val Pro Pro Gln Met Gln Gly Lys Ala Trp Gly Leu Arg Pro
     290                 295                 300                
 Glu Ser Ser Gln Lys Ala Ile Arg Glu Gly Thr Met Gly Ala Lys Thr
 305                 310                 315                 320
 Glu Arg Asp Leu Gly Pro Val Pro
                 325            



      <210> 1819
      <211> 65
      <212> PRT
      <213> Homo sapiens


      <400> 1819
 Ser Val Thr Met Thr Leu Thr Lys Gly Ser Phe Thr Tyr Ser Ser Gly
   1               5                  10                  15    
 Glu Glu Tyr Arg Gly Glu Trp Lys Glu Gly Arg Arg His Gly Phe Gly
              20                  25                  30        
 Gln Leu Met Phe Ala Asp Gly Gly Thr Tyr Leu Gly His Phe Glu Asn
          35                  40                  45            
 Gly Leu Phe Asn Gly Phe Gly Val Leu Thr Phe Ser Asp Gly Ser Arg
      50                  55                  60                
 Val
  65



      <210> 1820
      <211> 352
      <212> PRT
      <213> Homo sapiens


      <400> 1820
 Glu Gly Thr Met Pro Val Glu Arg Met Arg Met Arg Pro Trp Leu Glu
   1               5                  10                  15    
 Glu Gln Ile Asn Ser Asn Thr Ile Pro Gly Leu Lys Trp Leu Asn Lys
              20                  25                  30        
 Glu Lys Lys Ile Phe Gln Ile Pro Trp Met His Ala Ala Arg His Gly
          35                  40                  45            
 Trp Asp Val Glu Lys Asp Ala Pro Leu Phe Arg Asn Trp Ala Ile His
      50                  55                  60                
 Thr Gly Lys His Gln Pro Gly Val Asp Lys Pro Asp Pro Lys Thr Trp
  65                  70                  75                  80
 Lys Ala Asn Phe Arg Cys Ala Met Asn Ser Leu Pro Asp Ile Glu Glu
                  85                  90                  95    
 Val Lys Asp Lys Ser Ile Lys Lys Gly Asn Asn Ala Phe Arg Val Tyr
             100                 105                 110        
 Arg Met Leu Pro Leu Ser Lys Arg Pro Ser Lys Lys Gly Lys Lys Pro
         115                 120                 125            
 Lys Thr Glu Lys Glu Asp Lys Val Lys His Ile Lys Gln Glu Pro Val
     130                 135                 140                
 Glu Ser Ser Leu Gly Leu Ser Asn Gly Val Ser Asp Leu Ser Pro Glu
 145                 150                 155                 160
 Tyr Ala Val Leu Thr Ser Thr Ile Lys Asn Glu Val Asp Ser Thr Val
                 165                 170                 175    
 Asn Ile Ile Val Val Gly Gln Ser His Leu Asp Ser Asn Ile Glu Asn
             180                 185                 190        
 Gln Glu Ile Val Thr Asn Pro Pro Asp Ile Cys Gln Val Val Glu Val
         195                 200                 205            
 Thr Thr Glu Ser Asp Glu Gln Pro Val Ser Met Ser Glu Leu Tyr Pro
     210                 215                 220                
 Leu Gln Ile Ser Pro Val Ser Ser Tyr Ala Glu Ser Glu Thr Thr Asp
 225                 230                 235                 240
 Ser Val Pro Ser Asp Glu Glu Ser Ala Glu Gly Arg Pro His Trp Arg
                 245                 250                 255    
 Lys Arg Asn Ile Glu Gly Lys Gln Tyr Leu Ser Asn Met Gly Thr Arg
             260                 265                 270        
 Gly Ser Tyr Leu Leu Pro Gly Met Ala Ser Phe Val Thr Ser Asn Lys
         275                 280                 285            
 Pro Asp Leu Gln Val Thr Ile Lys Glu Glu Ser Asn Pro Val Pro Tyr
     290                 295                 300                
 Asn Ser Ser Trp Pro Pro Phe Gln Asp Leu Pro Leu Ser Ser Ser Met
 305                 310                 315                 320
 Thr Pro Ala Ser Ser Ser Ser Arg Pro Asp Arg Glu Thr Arg Ala Ser
                 325                 330                 335    
 Val Ile Lys Lys Thr Ser Asp Ile Thr Gln Ala Arg Val Lys Ser Cys
             340                 345                 350        





      <210> 1821
      <211> 179
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(179)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1821
 His Thr Asp Gly Phe Leu Val Trp Met Pro Phe Leu Phe Val Ser Phe
   1               5                  10                  15    
 Pro Ser Asn Ser Gln Asp Arg Gln Leu Gln Val Cys Trp Arg Leu Leu
              20                  25                  30        
 Glu Val His Ser Arg Pro Cys Phe Pro Gly Tyr Gln Gln Arg Trp Leu
          35                  40                  45            
 Gln Asn Asn Arg Tyr Ser Val Asn Arg Lys Cys Cys Cys Leu Ile Val
      50                  55                  60                
 Pro Leu Glu Val Leu Ser Gln Arg Ser Thr His Gln His Val Gly Glu
  65                  70                  75                  80
 Trp Leu Cys Leu Leu Gly Arg Lys Phe Pro Ala Gly Met Glu Ala Cys
                  85                  90                  95    
 Thr Ala Met Leu Cys Ser Ser Ser Val Leu Glu Ala Ala Thr Leu Ser
             100                 105                 110        
 Phe Ser Val Gln His Arg Ala Cys Thr Gly Gly Ser Xaa Lys Pro Gln
         115                 120                 125            
 Gln Gly Arg Val Tyr Pro Ser Glu Gly Arg Glu His Asn Gly Ala Ala
     130                 135                 140                
 Ala Phe Gly Pro Phe Cys Ser Ser Glu Cys Pro Ala Ser Cys Pro Asp
 145                 150                 155                 160
 Pro Gly Thr Gln Pro Cys Ala Pro Gly Thr Tyr Ile Pro Phe Phe Ser
                 165                 170                 175    
 Cys Gln Thr
            



      <210> 1822
      <211> 218
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(218)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1822
 Gln Ser Met Glu Glu Asn Gln Asp Leu Lys Lys Glu Leu Leu Lys Cys
   1               5                  10                  15    
 Lys Gln Glu Ala Arg Asn Leu Gln Gly Ile Lys Asp Ala Leu Gln Gln
              20                  25                  30        
 Arg Leu Thr Gln Gln Asp Thr Ser Val Leu Gln Leu Lys Gln Glu Leu
          35                  40                  45            
 Leu Arg Ala Asn Met Asp Lys Asp Glu Leu His Asn Gln Asn Val Asp
      50                  55                  60                
 Leu Gln Arg Lys Leu Asp Glu Arg Asn Arg Leu Leu Gly Glu Tyr Lys
  65                  70                  75                  80
 Lys Glu Leu Gly Gln Lys Asp Arg Leu Leu Gln Gln His Gln Ala Lys
                  85                  90                  95    
 Leu Glu Glu Ala Leu Arg Lys Leu Ser Asp Val Ser Tyr His Gln Val
             100                 105                 110        
 Asp Leu Glu Arg Glu Leu Glu His Lys Asp Val Leu Leu Ala His Cys
         115                 120                 125            
 Met Lys Arg Glu Ala Asp Glu Ala Thr Asn Tyr Asn Ser His Asn Ser
     130                 135                 140                
 Gln Ser Asn Gly Phe Leu Leu Pro Thr Ala Gly Lys Gly Ala Thr Ser
 145                 150                 155                 160
 Val Ser Asn Arg Gly Thr Ser Asp Leu Gln Leu Val Arg Asp Ala Leu
                 165                 170                 175    
 Arg Ser Leu Arg Asn Ser Phe Ser Gly His Asp Pro Gln His His Thr
             180                 185                 190        
 Ile Asp Ser Leu Glu Gln Gly Ile Ser Ser Leu Met Glu Arg Leu His
         195                 200                 205            
 Val Met Glu Thr Xaa Lys Lys Lys Lys Lys
     210                 215            



      <210> 1823
      <211> 57
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(57)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1823
 Ile His Gly Pro Gly Phe Arg Thr Xaa Asp His Val His Arg Gly Pro
   1               5                  10                  15    
 Pro Gly Pro Lys Arg Leu Asp Gln Gly Pro Ser Gly Thr Asp Gln Gly
              20                  25                  30        
 Ile Pro Ser Pro Ala Pro Gly Cys Pro Arg Ser Gln Gly His Leu Ala
          35                  40                  45            
 Gly Gln Arg Glu Pro Gly Thr Glu Arg
      50                  55        



      <210> 1824
      <211> 1025
      <212> PRT
      <213> Homo sapiens


      <400> 1824
 Asp Thr Pro Ala Trp His Gly Asp Ala Ala Met Ala Glu Ala Ala Leu
   1               5                  10                  15    
 Glu Ala Val Arg Ser Glu Leu Arg Glu Phe Pro Ala Ala Ala Arg Glu
              20                  25                  30        
 Leu Cys Val Pro Leu Ala Val Pro Tyr Leu Asp Lys Pro Pro Thr Pro
          35                  40                  45            
 Leu His Phe Tyr Arg Asp Trp Val Cys Pro Asn Arg Pro Cys Ile Ile
      50                  55                  60                
 Arg Asn Ala Leu Gln His Trp Pro Ala Leu Gln Lys Trp Ser Leu Pro
  65                  70                  75                  80
 Tyr Phe Arg Ala Thr Val Gly Ser Thr Glu Val Ser Val Ala Val Thr
                  85                  90                  95    
 Pro Asp Gly Tyr Ala Asp Ala Val Arg Gly Asp Arg Phe Met Met Pro
             100                 105                 110        
 Ala Glu Arg Arg Leu Pro Leu Ser Phe Val Leu Asp Val Leu Glu Gly
         115                 120                 125            
 Arg Ala Gln His Pro Gly Val Leu Tyr Val Gln Lys Gln Cys Ser Asn
     130                 135                 140                
 Leu Pro Ser Glu Leu Pro Gln Leu Leu Pro Asp Leu Glu Ser His Val
 145                 150                 155                 160
 Pro Trp Ala Ser Glu Ala Leu Gly Lys Met Pro Asp Ala Val Asn Phe
                 165                 170                 175    
 Trp Leu Gly Glu Ala Ala Ala Val Thr Ser Leu His Lys Asp His Tyr
             180                 185                 190        
 Glu Asn Leu Tyr Cys Val Val Ser Gly Glu Lys His Phe Leu Phe His
         195                 200                 205            
 Pro Pro Ser Asp Arg Pro Phe Ile Pro Tyr Glu Leu Tyr Thr Pro Ala
     210                 215                 220                
 Thr Tyr Gln Leu Thr Glu Glu Gly Thr Phe Lys Val Val Asp Glu Glu
 225                 230                 235                 240
 Ala Met Glu Lys Ala Glu Val Ser Arg Thr Cys Leu Leu Thr Val Arg
                 245                 250                 255    
 Val Leu Gln Ala His Arg Leu Pro Ser Lys Asp Leu Val Thr Pro Ser
             260                 265                 270        
 Asp Cys Tyr Val Thr Leu Trp Leu Pro Thr Ala Cys Ser His Arg Leu
         275                 280                 285            
 Gln Thr Arg Thr Val Lys Asn Ser Ser Ser Pro Val Trp Asn Gln Ser
     290                 295                 300                
 Phe His Phe Arg Ile His Arg Gln Leu Lys Asn Val Met Glu Leu Lys
 305                 310                 315                 320
 Val Phe Asp Gln Asp Leu Val Thr Gly Asp Asp Pro Val Leu Ser Val
                 325                 330                 335    
 Leu Phe Asp Ala Gly Thr Leu Arg Ala Gly Glu Phe Arg Arg Glu Ser
             340                 345                 350        
 Phe Ser Leu Ser Pro Gln Gly Glu Gly Arg Leu Glu Val Glu Phe Arg
         355                 360                 365            
 Leu Gln Ser Leu Ala Asp Arg Gly Glu Trp Leu Val Ser Asn Gly Val
     370                 375                 380                
 Leu Val Ala Arg Glu Leu Ser Cys Leu His Val Gln Leu Glu Glu Thr
 385                 390                 395                 400
 Gly Asp Gln Lys Ser Ser Glu His Arg Val Gln Leu Val Val Pro Gly
                 405                 410                 415    
 Ser Cys Glu Gly Pro Gln Glu Ala Ser Val Gly Thr Gly Thr Phe Arg
             420                 425                 430        
 Phe His Cys Pro Ala Cys Trp Glu Gln Glu Leu Ser Ile Arg Leu Gln
         435                 440                 445            
 Asp Ala Pro Glu Glu Gln Leu Lys Ala Pro Leu Ser Ala Leu Pro Ser
     450                 455                 460                
 Gly Gln Val Val Arg Leu Val Phe Pro Thr Ser Gln Glu Pro Leu Met
 465                 470                 475                 480
 Arg Val Glu Leu Lys Lys Glu Ala Gly Leu Arg Glu Leu Ala Val Arg
                 485                 490                 495    
 Leu Gly Phe Gly Pro Cys Ala Glu Glu Gln Ala Phe Leu Ser Arg Arg
             500                 505                 510        
 Lys Gln Val Val Ala Ala Ala Leu Arg Gln Ala Leu Gln Leu Asp Gly
         515                 520                 525            
 Asp Leu Gln Glu Asp Glu Ile Pro Val Val Ala Ile Met Ala Thr Gly
     530                 535                 540                
 Gly Gly Ile Arg Ala Met Thr Ser Leu Tyr Gly Gln Leu Ala Gly Leu
 545                 550                 555                 560
 Lys Glu Leu Gly Leu Leu Asp Cys Val Ser Tyr Ile Thr Gly Ala Ser
                 565                 570                 575    
 Gly Ser Thr Trp Ala Leu Ala Asn Leu Tyr Glu Asp Pro Glu Trp Ser
             580                 585                 590        
 Gln Lys Asp Leu Ala Gly Pro Thr Glu Leu Leu Lys Thr Gln Val Thr
         595                 600                 605            
 Lys Asn Lys Leu Gly Val Leu Ala Pro Ser Gln Leu Gln Arg Tyr Arg
     610                 615                 620                
 Gln Glu Leu Ala Glu Arg Ala Arg Leu Gly Tyr Pro Ser Cys Phe Thr
 625                 630                 635                 640
 Asn Leu Trp Ala Leu Ile Asn Glu Ala Leu Leu His Asp Glu Pro His
                 645                 650                 655    
 Asp His Lys Leu Ser Asp Gln Arg Glu Ala Leu Ser His Gly Gln Asn
             660                 665                 670        
 Pro Leu Pro Ile Tyr Cys Ala Leu Asn Thr Lys Gly Gln Ser Leu Thr
         675                 680                 685            
 Thr Phe Glu Phe Gly Glu Trp Cys Glu Phe Ser Pro Tyr Glu Val Gly
     690                 695                 700                
 Phe Pro Lys Tyr Gly Ala Phe Ile Pro Ser Glu Leu Phe Gly Ser Glu
 705                 710                 715                 720
 Phe Phe Met Gly Gln Leu Met Lys Arg Leu Pro Glu Ser Arg Ile Cys
                 725                 730                 735    
 Phe Leu Glu Gly Ile Trp Ser Asn Leu Tyr Ala Ala Asn Leu Gln Asp
             740                 745                 750        
 Ser Leu Tyr Trp Ala Ser Glu Pro Ser Gln Phe Trp Asp Arg Trp Val
         755                 760                 765            
 Ser Arg Asn Gln Ala Asn Leu Asp Lys Glu Gln Val Pro Leu Leu Lys
     770                 775                 780                
 Ile Glu Glu Pro Pro Ser Thr Ala Gly Arg Ile Ala Glu Phe Phe Thr
 785                 790                 795                 800
 Asp Leu Leu Thr Trp Arg Pro Leu Ala Gln Ala Thr His Asn Phe Leu
                 805                 810                 815    
 Arg Gly Leu His Phe His Lys Asp Tyr Phe Gln His Pro His Phe Ser
             820                 825                 830        
 Thr Trp Lys Ala Thr Thr Leu Asp Gly Leu Pro Asn Gln Leu Thr Pro
         835                 840                 845            
 Ser Glu Pro His Leu Cys Leu Leu Asp Val Gly Tyr Leu Ile Asn Thr
     850                 855                 860                
 Ser Cys Leu Pro Leu Leu Gln Pro Thr Arg Asp Val Asp Leu Ile Leu
 865                 870                 875                 880
 Ser Leu Asp Tyr Asn Leu His Gly Ala Phe Gln Gln Leu Gln Leu Leu
                 885                 890                 895    
 Gly Arg Phe Cys Gln Glu Gln Gly Ile Pro Phe Pro Pro Ile Ser Pro
             900                 905                 910        
 Ser Pro Glu Glu Gln Leu Gln Pro Arg Glu Cys His Thr Phe Ser Asp
         915                 920                 925            
 Pro Thr Cys Pro Gly Ala Pro Ala Val Leu His Phe Pro Leu Val Ser
     930                 935                 940                
 Asp Ser Phe Arg Glu Tyr Ser Ala Pro Gly Val Arg Arg Thr Pro Glu
 945                 950                 955                 960
 Glu Ala Ala Ala Gly Glu Val Asn Leu Ser Ser Ser Asp Ser Pro Tyr
                 965                 970                 975    
 His Tyr Thr Lys Val Thr Tyr Ser Gln Glu Asp Val Asp Lys Leu Leu
             980                 985                 990        
 His Leu Thr His Tyr Asn Val Cys Asn Asn Gln Glu Gln Leu Leu Glu
         995                1000                1005            
 Ala Leu Arg Pro Arg Gln Cys Lys Arg Lys Ala Ala Ala Gln Gly Pro
    1010                1015                1020                
 His
1025



      <210> 1825
      <211> 109
      <212> PRT
      <213> Homo sapiens


      <400> 1825
 Trp Val Phe Ser Ser Pro Ile Thr Ala Arg Asp Ala Leu Gly Ile Lys
   1               5                  10                  15    
 His Thr Met Val Lys Ile Arg Pro Leu Ser Gln Ala Thr Arg Ala Ala
              20                  25                  30        
 Lys Ala Lys Ala Arg Ala Tyr Ala Glu Phe Leu Gln Pro Ala Lys Glu
          35                  40                  45            
 Arg Pro Glu Thr Ser Ala Ala Leu Ala Arg Arg Leu Val Ile Ser Ala
      50                  55                  60                
 Leu Gly Val Arg Ser Lys Gln Ser Lys Thr Glu Arg Glu Ala Glu Leu
  65                  70                  75                  80
 Lys Lys Leu Gln Glu Ala Arg Glu Arg Lys Arg Leu Glu Ala Lys Gln
                  85                  90                  95    
 Arg Glu Asp Ile Trp Glu Gly Arg Asp Gln Ser Thr Val
             100                 105                



      <210> 1826
      <211> 245
      <212> PRT
      <213> Homo sapiens


      <400> 1826
 Met Ser Gln Gly Thr Thr Pro Trp Gly Pro Thr Pro Ala Gly Thr Thr
   1               5                  10                  15    
 Pro Glu Ser Glu Val His Arg Pro Phe Pro Phe Pro Val Pro Val Pro
              20                  25                  30        
 Val Pro Glu Thr Ser Glu Arg Ser Phe Pro Val Arg Gly Val Cys Gly
          35                  40                  45            
 Gln Ala Lys Ser Gly Leu Arg Arg Gly Ala Ala Arg Leu Ala Pro Ala
      50                  55                  60                
 Ala Tyr Leu Phe Thr Arg Gln Gln Thr Arg Glu Leu Ile His Ser Ala
  65                  70                  75                  80
 Cys Val Ser Ile Ser Val Asn Thr Met His Gly Leu Ser Val Ala Ile
                  85                  90                  95    
 Asn Ser Arg Arg Cys Thr Tyr Tyr Arg Lys Tyr Val Ile Asp Phe Ser
             100                 105                 110        
 Lys Ser Glu Ile Ile Gly Ile Pro Ile Ser Lys Asn Ile Asp Leu Thr
         115                 120                 125            
 Val Gly Thr Thr Val Thr Gln Leu Gln Asn Leu Asn Thr Val Gly Ile
     130                 135                 140                
 Ile Gly Ser Arg Gly Gly Arg Gly Gln Val Ala Ala Leu Asn Cys Asp
 145                 150                 155                 160
 Arg Gln Gly His Leu Trp Leu Phe Thr Arg Val Thr Val His Trp Arg
                 165                 170                 175    
 Met Gly Asn Asp Arg Thr Phe Trp Gly Leu Leu Asp Thr Val Ser Glu
             180                 185                 190        
 Leu Met Phe Ile Pro Gly Asn Pro Lys His His Cys Gly Pro Pro Val
         195                 200                 205            
 Lys Val Gly Ala Tyr Gly Asp Gln Val Ala Leu Met Ala Ser Trp Arg
     210                 215                 220                
 Val Pro Tyr Asp Gln Leu Thr Glu Glu Gln Lys Thr Arg Ala Trp Phe
 225                 230                 235                 240
 Thr Asp Gly Ser Ala
                 245



      <210> 1827
      <211> 161
      <212> PRT
      <213> Homo sapiens


      <400> 1827
 Glu Val Lys Met Ala Gly Phe Leu Asp Asn Phe Arg Trp Pro Glu Cys
   1               5                  10                  15    
 Glu Cys Ile Asp Trp Ser Glu Arg Arg Asn Ala Val Ala Ser Val Val
              20                  25                  30        
 Ala Gly Ile Leu Phe Phe Thr Gly Trp Trp Ile Met Ile Asp Ala Ala
          35                  40                  45            
 Val Val Tyr Pro Lys Pro Glu Gln Leu Asn His Ala Phe His Thr Cys
      50                  55                  60                
 Gly Val Phe Ser Thr Leu Ala Phe Phe Met Ile Asn Ala Val Ser Asn
  65                  70                  75                  80
 Ala Gln Val Arg Gly Asp Ser Tyr Glu Ser Gly Cys Leu Gly Arg Thr
                  85                  90                  95    
 Gly Ala Arg Val Trp Leu Phe Ile Gly Phe Met Leu Met Phe Gly Ser
             100                 105                 110        
 Leu Ile Ala Ser Met Trp Ile Leu Phe Gly Ala Tyr Val Thr Gln Asn
         115                 120                 125            
 Thr Asp Val Tyr Pro Gly Leu Ala Val Phe Phe Gln Asn Ala Leu Ile
     130                 135                 140                
 Phe Phe Ser Thr Leu Ile Tyr Lys Phe Gly Arg Thr Glu Glu Leu Trp
 145                 150                 155                 160
 Thr
    



      <210> 1828
      <211> 459
      <212> PRT
      <213> Homo sapiens


      <400> 1828
 His Ala Ser Val Leu Phe Cys Arg Val Met Ala Ala Ser Lys Thr Gln
   1               5                  10                  15    
 Gly Ala Val Ala Arg Met Gln Glu Asp Arg Asp Gly Ser Cys Ser Thr
              20                  25                  30        
 Val Gly Gly Val Gly Tyr Gly Asp Ser Lys Asp Cys Ile Leu Glu Pro
          35                  40                  45            
 Leu Ser Leu Pro Glu Ser Pro Gly Gly Thr Thr Thr Leu Glu Gly Ser
      50                  55                  60                
 Pro Ser Val Pro Cys Ile Phe Cys Glu Glu His Phe Pro Val Ala Glu
  65                  70                  75                  80
 Gln Asp Lys Leu Leu Lys His Met Ile Ile Glu His Lys Ile Val Ile
                  85                  90                  95    
 Ala Asp Val Lys Leu Val Ala Asp Phe Gln Arg Tyr Ile Leu Tyr Trp
             100                 105                 110        
 Arg Lys Arg Phe Thr Glu Gln Pro Ile Thr Asp Phe Cys Ser Val Ile
         115                 120                 125            
 Arg Ile Asn Ser Thr Ala Pro Phe Glu Glu Gln Glu Asn Tyr Phe Leu
     130                 135                 140                
 Leu Cys Asp Val Leu Pro Glu Asp Arg Ile Leu Arg Glu Glu Leu Gln
 145                 150                 155                 160
 Lys Gln Arg Leu Arg Glu Ile Leu Glu Gln Gln Gln Gln Glu Arg Asn
                 165                 170                 175    
 Asp Thr Asn Phe His Gly Val Cys Met Phe Cys Asn Glu Glu Phe Leu
             180                 185                 190        
 Gly Asn Arg Ser Val Ile Leu Asn His Met Ala Arg Glu His Ala Phe
         195                 200                 205            
 Asn Ile Gly Leu Pro Asp Asn Ile Val Asn Cys Asn Glu Phe Leu Cys
     210                 215                 220                
 Thr Leu Gln Lys Lys Leu Asp Asn Leu Gln Cys Leu Tyr Cys Glu Lys
 225                 230                 235                 240
 Thr Phe Arg Asp Lys Asn Thr Leu Lys Asp His Met Arg Lys Lys Gln
                 245                 250                 255    
 His Arg Lys Ile Asn Pro Lys Asn Arg Glu Tyr Asp Arg Phe Tyr Val
             260                 265                 270        
 Ile Asn Tyr Leu Glu Leu Gly Lys Ser Trp Glu Glu Val Gln Leu Glu
         275                 280                 285            
 Asp Asp Arg Glu Leu Leu Asp His Gln Glu Asp Asp Trp Ser Asp Trp
     290                 295                 300                
 Glu Glu His Pro Ala Ser Ala Val Cys Leu Phe Cys Glu Lys Gln Ala
 305                 310                 315                 320
 Glu Thr Ile Glu Lys Leu Tyr Val His Met Glu Asp Ala His Glu Phe
                 325                 330                 335    
 Asp Leu Leu Lys Ile Lys Ser Glu Leu Gly Leu Asn Phe Tyr Gln Gln
             340                 345                 350        
 Val Lys Leu Val Asn Phe Ile Arg Arg Gln Val His Gln Cys Arg Cys
         355                 360                 365            
 Tyr Gly Cys His Val Lys Phe Lys Ser Lys Ala Asp Leu Arg Thr His
     370                 375                 380                
 Met Glu Glu Thr Lys His Thr Ser Leu Leu Pro Asp Arg Lys Thr Trp
 385                 390                 395                 400
 Asp Gln Leu Glu Tyr Tyr Phe Pro Thr Tyr Glu Asn Asp Thr Leu Leu
                 405                 410                 415    
 Trp Thr Leu Ser Asp Ser Glu Ser Asp Leu Thr Ala Gln Glu Gln Asn
             420                 425                 430        
 Glu Asn Val Pro Ile Ile Ser Glu Asp Thr Ser Lys Leu Tyr Ala Leu
         435                 440                 445            
 Lys Gln Ser Ser Ile Leu Asn Gln Leu Leu Leu
     450                 455                



      <210> 1829
      <211> 234
      <212> PRT
      <213> Homo sapiens


      <400> 1829
 Pro Ala Pro Leu Ala Glu Gly Ala Phe Leu Ala Glu Ala Ser Leu Leu
   1               5                  10                  15    
 Lys Leu Ser Pro Ala Thr Pro Thr Ser Glu Gly Pro Lys Val Val Ser
              20                  25                  30        
 Val Gln Leu Gly Asp Gly Thr Arg Leu Lys Gly Thr Val Leu Pro Val
          35                  40                  45            
 Ala Thr Ile Gln Asn Ala Ser Thr Ala Met Leu Met Ala Ala Ser Val
      50                  55                  60                
 Ala Arg Lys Ala Val Val Leu Pro Gly Gly Thr Ala Thr Ser Pro Lys
  65                  70                  75                  80
 Met Ile Ala Lys Asn Val Leu Gly Leu Val Pro Gln Ala Leu Pro Lys
                  85                  90                  95    
 Ala Asp Gly Arg Ala Gly Leu Gly Thr Gly Gly Gln Lys Val Asn Gly
             100                 105                 110        
 Ala Ser Val Val Met Val Gln Pro Ser Lys Thr Ala Thr Gly Pro Ser
         115                 120                 125            
 Thr Gly Gly Gly Thr Val Ile Ser Arg Thr Gln Ser Ser Leu Val Glu
     130                 135                 140                
 Ala Phe Asn Lys Ile Leu Asn Ser Lys Asn Leu Leu Pro Ala Tyr Arg
 145                 150                 155                 160
 Pro Asn Leu Ser Pro Pro Ala Glu Ala Gly Leu Ala Leu Pro Pro Thr
                 165                 170                 175    
 Gly Tyr Arg Cys Leu Glu Cys Gly Asp Ala Phe Ser Leu Glu Lys Ser
             180                 185                 190        
 Leu Ala Arg His Tyr Asp Arg Arg Ser Met Arg Ile Glu Val Thr Cys
         195                 200                 205            
 Asn His Cys Ala Arg Arg Leu Val Phe Phe Asn Lys Cys Ser Leu Leu
     210                 215                 220                
 Leu His Ala Arg Glu His Lys Asp Lys Gly
 225                 230                



      <210> 1830
      <211> 271
      <212> PRT
      <213> Homo sapiens


      <400> 1830
 Cys Gly Ile Arg Thr Arg Ala Pro Val Val Thr Ala Pro Gly Gly Ala
   1               5                  10                  15    
 Leu Leu Arg Ala Gly Ala Gly Arg Leu Leu Arg Gly Gly Val Gln Glu
              20                  25                  30        
 Leu Leu Arg Pro Arg His Glu Gly Asn Ala Pro Asp Leu Ala Cys Asn
          35                  40                  45            
 Phe Ser Leu Ser Gln Asn Arg Gly Thr Val Ile Val Glu Arg Trp Trp
      50                  55                  60                
 Lys Val Pro Leu Ala Gly Glu Gly Arg Lys Pro Arg Leu His Arg Arg
  65                  70                  75                  80
 His Arg Val Tyr Lys Leu Val Glu Asp Thr Lys His Arg Pro Lys Glu
                  85                  90                  95    
 Asn Leu Glu Leu Ile Leu Thr Gln Ser Val Glu Asn Val Gly Val Arg
             100                 105                 110        
 Gly Asp Leu Val Ser Val Lys Lys Ser Leu Gly Arg Asn Arg Leu Leu
         115                 120                 125            
 Pro Gln Gly Leu Ala Val Tyr Ala Ser Pro Glu Asn Lys Lys Leu Phe
     130                 135                 140                
 Glu Glu Glu Lys Leu Leu Arg Gln Glu Gly Lys Leu Glu Lys Ile Gln
 145                 150                 155                 160
 Thr Lys Ala Gly Glu Ala Thr Val Lys Phe Leu Lys Ser Cys Arg Leu
                 165                 170                 175    
 Glu Val Gly Met Lys Asn Asn Val Lys Trp Glu Leu Asn Pro Glu Ile
             180                 185                 190        
 Val Ala Arg His Phe Phe Lys Asn Leu Gly Val Val Val Ala Pro His
         195                 200                 205            
 Thr Leu Lys Leu Pro Ala Glu Pro Ile Thr Arg Trp Gly Glu Tyr Trp
     210                 215                 220                
 Cys Glu Val Thr Val Asn Gly Leu Asp Thr Val Arg Val Pro Met Ser
 225                 230                 235                 240
 Val Val Asn Phe Glu Lys Pro Lys Thr Lys Arg Tyr Lys Tyr Trp Leu
                 245                 250                 255    
 Ala Gln Gln Ala Ala Lys Ala Met Ala Pro Thr Ser Pro Gln Ile
             260                 265                 270    



      <210> 1831
      <211> 143
      <212> PRT
      <213> Homo sapiens


      <400> 1831
 Lys Gly Pro Ser Tyr Gly Leu Ala Ala Glu Val Lys Asn Arg Leu Leu
   1               5                  10                  15    
 Ser Lys Tyr Asp Pro Gln Lys Glu Ala Glu Leu Arg Thr Trp Ile Glu
              20                  25                  30        
 Gly Leu Thr Gly Leu Ser Ile Gly Pro Asp Phe Gln Lys Gly Leu Lys
          35                  40                  45            
 Asp Gly Thr Ile Leu Cys Thr Leu Met Asn Lys Leu Gln Pro Gly Ser
      50                  55                  60                
 Val Pro Lys Ile Asn Arg Ser Met Gln Asn Trp His Gln Leu Glu Asn
  65                  70                  75                  80
 Leu Ser Asn Phe Ile Lys Ala Met Val Ser Tyr Gly Met Asn Pro Val
                  85                  90                  95    
 Asp Leu Phe Glu Ala Asn Asp Leu Phe Glu Ser Gly Asn Met Thr Gln
             100                 105                 110        
 Val Gln Ala Lys Thr Lys Gly Leu Gln Ser Gly Val Asp Ile Gly Val
         115                 120                 125            
 Lys Tyr Ser Glu Lys Gln Glu Arg Asn Phe Asp Asp Ala Thr Met
     130                 135                 140            



      <210> 1832
      <211> 167
      <212> PRT
      <213> Homo sapiens


      <400> 1832
 Ala Pro Ala Ala Gly Gly Glu Leu Gly Phe His Gly Ala Ala Ala Glu
   1               5                  10                  15    
 Ala Gly Pro Ala Ala Met Asn Arg Phe Asn Gly Leu Cys Lys Val Cys
              20                  25                  30        
 Ser Glu Arg Arg Tyr Arg Gln Ile Thr Ile Pro Arg Gly Lys Asp Gly
          35                  40                  45            
 Phe Gly Phe Thr Ile Cys Cys Asp Ser Pro Val Arg Val Gln Ala Val
      50                  55                  60                
 Asp Ser Gly Gly Pro Ala Glu Arg Ala Gly Leu Gln Gln Leu Asp Thr
  65                  70                  75                  80
 Val Leu Gln Leu Asn Glu Arg Pro Val Glu His Trp Lys Cys Val Glu
                  85                  90                  95    
 Leu Ala His Glu Ile Arg Ser Cys Pro Ser Glu Ile Ile Leu Leu Val
             100                 105                 110        
 Trp Arg Met Val Pro Gln Val Lys Pro Gly Pro Asp Gly Gly Val Leu
         115                 120                 125            
 Arg Arg Ala Ser Cys Lys Ser Thr His Asp Leu Gln Ser Pro Pro Asn
     130                 135                 140                
 Lys Arg Glu Lys Asn Cys Thr His Gly Val Gln Ala Arg Pro Glu Ala
 145                 150                 155                 160
 Ala Pro Gln Leu Pro Pro Gly
                 165        



      <210> 1833
      <211> 69
      <212> PRT
      <213> Homo sapiens


      <400> 1833
 Ala Trp Gly Ala Glu His Cys Phe Phe Ser Ala Leu Thr Glu Pro Ser
   1               5                  10                  15    
 Ala Ser Pro Ala Ala Gly Leu Gly Ile Phe Glu Val Arg Arg Gly Glu
              20                  25                  30        
 Asn Pro Val Ala Trp Ser Ser Leu Ala Leu Phe Ser Ser Glu Tyr Leu
          35                  40                  45            
 Gly Leu Glu Gly Arg Gly Trp Gly Leu Met His Ile Val Phe Phe Phe
      50                  55                  60                
 Pro Cys Ile Pro Lys
  65                



      <210> 1834
      <211> 158
      <212> PRT
      <213> Homo sapiens


      <400> 1834
 Met Ser Ser Trp His Ser Arg Leu Asp Trp Gln Trp Arg Asn His Phe
   1               5                  10                  15    
 Asn Phe Asp His Phe Glu Ile Leu Arg Ala Ile Gly Lys Gly Ser Phe
              20                  25                  30        
 Gly Lys Val Cys Ile Val Gln Lys Asn Asp Thr Lys Lys Met Tyr Ala
          35                  40                  45            
 Met Lys Tyr Met Asn Lys Gln Lys Cys Val Glu Arg Asn Glu Val Arg
      50                  55                  60                
 Asn Val Phe Lys Glu Leu Gln Ile Met Gln Gly Leu Glu His Pro Phe
  65                  70                  75                  80
 Leu Val Asn Leu Cys Ser Pro Ala Met Asp Pro Asn Gln Glu Glu Ile
                  85                  90                  95    
 Pro Asp Leu Pro Glu Lys Glu Phe Arg Arg Leu Ala Ile Lys Leu Ile
             100                 105                 110        
 Arg Glu Glu Pro Glu Lys Gly Glu Ala Gln Cys Lys Gly Ile Gln Asn
         115                 120                 125            
 Met Ile Gln Glu Val Lys Gly Glu Ile Phe Lys Gln Ile Asp Ser Leu
     130                 135                 140                
 Lys Lys Lys Gln Tyr Lys Ile Gln Glu Thr Leu Asp Thr Leu
 145                 150                 155            



      <210> 1835
      <211> 477
      <212> PRT
      <213> Homo sapiens


      <400> 1835
 Phe Tyr Asp Leu Leu Arg Ile Thr Leu Gly Arg Arg Gly Gln Tyr Val
   1               5                  10                  15    
 Met Leu Ser Val Cys Leu Glu Arg Ala Met Lys Val Ala Phe Gly Glu
              20                  25                  30        
 Phe His Leu Trp Tyr Gln Val Ala Leu Ser Met Val Ala Cys Gly Lys
          35                  40                  45            
 Ser Ala Tyr Ala Val Ser Leu Leu Arg Glu Cys Val Lys Leu Arg Pro
      50                  55                  60                
 Ser Asp Pro Thr Val Pro Leu Met Ala Ala Lys Val Cys Ile Gly Ser
  65                  70                  75                  80
 Leu Arg Trp Leu Glu Glu Ala Glu His Phe Ala Met Met Val Ile Ser
                  85                  90                  95    
 Leu Gly Glu Glu Ala Gly Glu Phe Leu Pro Lys Gly Tyr Leu Ala Leu
             100                 105                 110        
 Gly Leu Thr Tyr Ser Leu Gln Ala Thr Asp Ala Thr Leu Lys Ser Lys
         115                 120                 125            
 Gln Asp Glu Leu His Arg Lys Ala Leu Gln Thr Leu Glu Arg Ala Gln
     130                 135                 140                
 Gln Leu Ala Pro Ser Asp Pro Gln Val Ile Leu Tyr Val Ser Leu Gln
 145                 150                 155                 160
 Leu Ala Leu Val Arg Gln Ile Ser Ser Ala Met Glu Gln Leu Gln Glu
                 165                 170                 175    
 Ala Leu Lys Val Arg Lys Asp Asp Ala His Ala Leu His Leu Leu Ala
             180                 185                 190        
 Leu Leu Phe Ser Ala Gln Lys His His Gln His Ala Leu Asp Val Val
         195                 200                 205            
 Asn Met Ala Ile Thr Glu His Pro Glu Asn Phe Asn Leu Met Phe Thr
     210                 215                 220                
 Lys Val Lys Leu Glu Gln Val Leu Lys Gly Pro Glu Glu Ala Leu Val
 225                 230                 235                 240
 Thr Cys Arg Gln Val Leu Arg Leu Trp Gln Thr Leu Tyr Ser Phe Ser
                 245                 250                 255    
 Gln Leu Gly Gly Leu Glu Lys Asp Gly Ser Phe Gly Glu Gly Leu Thr
             260                 265                 270        
 Met Lys Lys Gln Ser Gly Met His Leu Thr Leu Pro Asp Ala His Asp
         275                 280                 285            
 Ala Asp Ser Gly Ser Arg Arg Ala Ser Ser Ile Ala Ala Ser Arg Leu
     290                 295                 300                
 Glu Glu Ala Met Ser Glu Leu Thr Met Pro Ser Ser Val Leu Lys Gln
 305                 310                 315                 320
 Gly Pro Met Gln Leu Trp Thr Lys Leu Glu Gln Ile Trp Leu Gln Ala
                 325                 330                 335    
 Ala Glu Leu Phe Met Glu Gln Gln His Leu Lys Glu Ala Gly Phe Cys
             340                 345                 350        
 Ile Gln Glu Ala Ala Gly Leu Phe Pro Thr Ser His Ser Val Leu Tyr
         355                 360                 365            
 Met Arg Gly Arg Leu Ala Glu Val Lys Gly Asn Leu Glu Glu Ala Lys
     370                 375                 380                
 Gln Leu Tyr Lys Glu Ala Leu Thr Val Asn Pro Asp Gly Val Arg Ile
 385                 390                 395                 400
 Met His Ser Leu Gly Leu Met Leu Ser Arg Leu Gly His Lys Ser Leu
                 405                 410                 415    
 Ala Gln Lys Val Leu Arg Asp Ala Val Glu Arg Gln Ser Thr Cys His
             420                 425                 430        
 Glu Ala Trp Gln Gly Leu Gly Glu Val Leu Gln Ala Gln Gly Gln Asn
         435                 440                 445            
 Glu Ala Ala Val Asp Cys Phe Leu Thr Ala Leu Glu Leu Glu Ala Ser
     450                 455                 460                
 Ser Pro Val Leu Pro Phe Ser Ile Ile Pro Arg Glu Leu
 465                 470                 475        



      <210> 1836
      <211> 115
      <212> PRT
      <213> Homo sapiens


      <400> 1836
 Gly Leu Ser Arg Ala Ala Met Val Trp Trp Gln Gln Ala Gln Pro Ser
   1               5                  10                  15    
 Leu Glu Met Gln Asn Asp Ala Gly Glu Phe Val Asp Leu Tyr Val Pro
              20                  25                  30        
 Arg Lys Cys Ser Ala Ser Asn Arg Ile Ile Gly Ala Lys Asp His Ala
          35                  40                  45            
 Ser Ile Gln Met Asn Val Ala Arg Leu Thr Arg Ser Gln Ala Gly Leu
      50                  55                  60                
 Met Ala Ser Leu Lys Leu Met Leu Ser Ala Gly Pro Phe Val Gly Trp
  65                  70                  75                  80
 Val Ser Gln Met Ile Pro Phe Ser Asp Trp Pro Arg Arg Trp His Arg
                  85                  90                  95    
 Leu Lys Glu Leu Leu Thr Gly Glu Asn His Arg Cys Gly Ile Phe Val
             100                 105                 110        
 Ile Asn Lys
         115



      <210> 1837
      <211> 113
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(113)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1837
 Ala Arg Gly Glu Leu Leu Leu Ser Arg Xaa Ala Pro Xaa Glu Val Lys
   1               5                  10                  15    
 Gly His Phe Leu Ala Leu Gly Tyr Phe Val Ser Thr Ala Lys Ala Glu
              20                  25                  30        
 Asn Leu Pro Xaa Arg Leu Trp Ser Ser Cys Pro Gln Ala Gln Asn Gln
          35                  40                  45            
 Ile Pro Leu Phe Leu Lys Ala Ser Leu His His His Ile Ser Val Ser
      50                  55                  60                
 His Thr Asp Xaa Leu Leu Pro Ala Met Asn Ser Gln Arg Phe Pro His
  65                  70                  75                  80
 Pro Phe Asp Ser Ile Thr Thr Ser Asp Asp Leu Arg Ser Val Leu Gln
                  85                  90                  95    
 His Tyr Asn Ser Leu Thr Xaa Leu Thr Cys Asn Pro Asp Thr Gln Asp
             100                 105                 110        
 Arg
    



      <210> 1838
      <211> 708
      <212> PRT
      <213> Homo sapiens


      <400> 1838
 Asn Val Ile Gln Arg Met Lys Leu Val Ile Glu Lys Met Ala Ser Pro
   1               5                  10                  15    
 Lys Gly His His Val Thr Asp Ser Glu Asn Asp Glu Pro Leu Asn Leu
              20                  25                  30        
 Asn Ala Ser Asp Ser Glu Ser Glu Glu Leu His Arg Gln Lys Asp Ser
          35                  40                  45            
 Asp Ser Glu Ser Glu Glu Arg Ala Glu Pro Pro Ala Ser Asp Ser Glu
      50                  55                  60                
 Asn Glu Asp Val Asn Gln His Gly Ser Asp Ser Glu Ser Glu Glu Thr
  65                  70                  75                  80
 Arg Lys Leu Pro Gly Ser Asp Ser Glu Asn Glu Glu Leu Leu Asn Gly
                  85                  90                  95    
 His Ala Ser Asp Ser Glu Asn Glu Asp Val Gly Lys His Pro Ala Ser
             100                 105                 110        
 Asp Ser Glu Ile Glu Glu Leu Gln Lys Ser Pro Ala Ser Asp Ser Glu
         115                 120                 125            
 Thr Glu Asp Ala Leu Lys Pro Gln Ile Ser Asp Ser Glu Ser Glu Glu
     130                 135                 140                
 Pro Pro Arg His Gln Ala Ser Asp Ser Glu Asn Glu Glu Pro Pro Lys
 145                 150                 155                 160
 Pro Arg Met Ser Asp Ser Glu Ser Glu Glu Leu Pro Lys Pro Gln Val
                 165                 170                 175    
 Ser Asp Ser Glu Ser Glu Glu Pro Pro Arg His Gln Ala Ser Asp Ser
             180                 185                 190        
 Glu Asn Glu Glu Leu Pro Lys Pro Arg Ile Ser Asp Ser Lys Ser Glu
         195                 200                 205            
 Asp Pro Pro Arg His Gln Ala Ser Asp Ser Glu Asn Glu Glu Leu Pro
     210                 215                 220                
 Lys Pro Arg Ile Ser Asp Ser Glu Ser Glu Asp Pro Pro Arg Asn Gln
 225                 230                 235                 240
 Ala Ser Asp Ser Glu Asn Glu Glu Leu Pro Lys Pro Arg Val Ser Asp
                 245                 250                 255    
 Ser Glu Ser Glu Gly Pro Gln Lys Gly Pro Ala Ser Asp Ser Glu Thr
             260                 265                 270        
 Glu Asp Ala Ser Arg His Lys Gln Lys Pro Glu Ser Asp Asp Asp Ser
         275                 280                 285            
 Asp Arg Glu Asn Lys Gly Glu Asp Thr Glu Met Gln Asn Asp Ser Phe
     290                 295                 300                
 His Ser Asp Ser His Met Asp Arg Lys Lys Phe His Ser Ser Asp Ser
 305                 310                 315                 320
 Glu Glu Glu Glu His Lys Lys Lys Lys Met Asp Ser Asp Glu Asp Glu
                 325                 330                 335    
 Lys Glu Gly Glu Glu Glu Lys Val Ala Lys Arg Lys Ala Ala Val Leu
             340                 345                 350        
 Ser Asp Ser Glu Asp Glu Glu Lys Ala Ser Ala Lys Lys Ser Arg Val
         355                 360                 365            
 Val Ser Asp Ala Asp Asp Ser Asp Ser Asp Ala Val Ser Asp Lys Ser
     370                 375                 380                
 Gly Lys Arg Glu Lys Thr Ile Ala Ser Asp Ser Glu Glu Glu Ala Gly
 385                 390                 395                 400
 Lys Glu Leu Ser Asp Lys Lys Asn Glu Glu Lys Asp Leu Phe Gly Ser
                 405                 410                 415    
 Asp Ser Glu Ser Gly Asn Glu Glu Glu Asn Leu Ile Ala Asp Ile Phe
             420                 425                 430        
 Gly Glu Ser Gly Asp Glu Glu Glu Glu Glu Phe Thr Gly Phe Asn Gln
         435                 440                 445            
 Glu Asp Leu Glu Glu Glu Lys Gly Glu Thr Gln Val Lys Glu Ala Glu
     450                 455                 460                
 Asp Ser Asp Ser Asp Asp Asn Ile Lys Arg Gly Lys His Met Asp Phe
 465                 470                 475                 480
 Leu Ser Asp Phe Glu Met Met Leu Gln Arg Lys Lys Ser Met Ser Gly
                 485                 490                 495    
 Lys Arg Arg Arg Asn Arg Asp Gly Gly Thr Phe Ile Ser Asp Ala Asp
             500                 505                 510        
 Asp Val Val Ser Ala Met Ile Val Lys Met Asn Glu Ala Ala Glu Glu
         515                 520                 525            
 Asp Arg Gln Leu Asn Asn Gln Lys Lys Pro Ala Leu Lys Lys Leu Thr
     530                 535                 540                
 Leu Leu Pro Ala Val Val Met His Leu Lys Lys Gln Asp Leu Lys Glu
 545                 550                 555                 560
 Thr Phe Ile Asp Ser Gly Val Met Ser Ala Ile Lys Glu Trp Leu Ser
                 565                 570                 575    
 Pro Leu Pro Asp Arg Ser Leu Pro Ala Leu Lys Ile Arg Glu Glu Leu
             580                 585                 590        
 Leu Lys Ile Leu Gln Glu Leu Pro Ser Val Ser Gln Glu Thr Leu Lys
         595                 600                 605            
 His Ser Gly Ile Gly Arg Ala Val Met Tyr Leu Tyr Lys His Pro Lys
     610                 615                 620                
 Glu Ser Arg Ser Asn Lys Asp Met Ala Gly Lys Leu Ile Asn Glu Trp
 625                 630                 635                 640
 Ser Arg Pro Ile Phe Gly Leu Thr Ser Asn Tyr Lys Gly Met Thr Arg
                 645                 650                 655    
 Glu Glu Arg Glu Gln Arg Asp Leu Glu Gln Met Pro Gln Arg Arg Lys
             660                 665                 670        
 Met Asn Ser Thr Gly Gly Gln Thr Pro Arg Arg Asp Leu Glu Lys Val
         675                 680                 685            
 Leu Thr Gly Glu Glu Lys Ala Leu Arg Pro Gly Asp Pro Gly Phe Val
     690                 695                 700                
 Pro Arg Ala Arg
 705            



      <210> 1839
      <211> 254
      <212> PRT
      <213> Homo sapiens


      <400> 1839
 Ser Arg Val Asp Asp Phe Val Arg Pro Glu Pro Ser Arg Ala Glu Pro
   1               5                  10                  15    
 Ser Arg Ser Gly Arg Arg Arg Pro Ala Arg Arg Ala Ala Thr Met Ser
              20                  25                  30        
 Val Phe Gly Lys Leu Phe Gly Ala Gly Gly Gly Lys Ala Gly Lys Gly
          35                  40                  45            
 Gly Pro Thr Pro Gln Glu Ala Ile Gln Arg Leu Arg Asp Thr Glu Glu
      50                  55                  60                
 Met Leu Ser Lys Lys Gln Glu Phe Leu Glu Lys Lys Ile Glu Gln Glu
  65                  70                  75                  80
 Leu Thr Ala Ala Lys Lys His Gly Thr Lys Asn Lys Arg Ala Ala Leu
                  85                  90                  95    
 Gln Ala Leu Lys Arg Lys Lys Arg Tyr Glu Lys Gln Leu Ala Gln Ile
             100                 105                 110        
 Asp Gly Thr Leu Ser Thr Ile Glu Phe Gln Arg Glu Ala Leu Glu Asn
         115                 120                 125            
 Ala Asn Thr Asn Thr Glu Val Leu Lys Asn Met Gly Tyr Ala Ala Lys
     130                 135                 140                
 Ala Met Lys Ala Ala His Asp Asn Met Asp Ile Asp Lys Val Asp Glu
 145                 150                 155                 160
 Leu Met Gln Asp Ile Ala Asp Gln Gln Glu Leu Ala Glu Glu Ile Ser
                 165                 170                 175    
 Thr Ala Ile Ser Lys Pro Val Gly Phe Gly Glu Glu Phe Asp Glu Asp
             180                 185                 190        
 Glu Leu Met Ala Glu Leu Glu Glu Leu Glu Gln Glu Glu Leu Asp Lys
         195                 200                 205            
 Asn Leu Leu Glu Ile Ser Gly Pro Glu Thr Val Pro Leu Pro Asn Val
     210                 215                 220                
 Pro Ser Ile Ala Leu Pro Ser Lys Pro Ala Lys Lys Lys Glu Glu Glu
 225                 230                 235                 240
 Asp Asp Asp Met Lys Glu Leu Glu Asn Trp Ala Gly Ser Met
                 245                 250                



      <210> 1840
      <211> 44
      <212> PRT
      <213> Homo sapiens


      <400> 1840
 Met Asn Gly Thr Arg Ser Ala Leu Thr Gly Gly Arg Ser Ala Ala Ser
   1               5                  10                  15    
 Leu Arg Asp Asp Arg Arg Pro Val Ala Leu Pro Ala Glu Glu Glu Glu
              20                  25                  30        
 Asp Lys Arg Glu Glu Val Glu Arg Leu Val Lys Glu
          35                  40                



      <210> 1841
      <211> 625
      <212> PRT
      <213> Homo sapiens


      <400> 1841
 Arg Ala Pro Met Met Thr Lys Ala Val Pro Glu Glu Pro Arg Lys Pro
   1               5                  10                  15    
 Gly Arg Leu Thr Gln Ala Leu Asn Ser Pro Leu Thr Trp Glu His Val
              20                  25                  30        
 Trp Ile Cys Val Pro Gly Gly Thr Pro Asp Cys Leu Thr Asp Thr Phe
          35                  40                  45            
 Arg Val Lys Arg Pro His Leu Arg Arg Ser Ala Ser Asn Gly His Val
      50                  55                  60                
 Pro Gly Thr Pro Val Tyr Arg Glu Lys Glu Asp Met Tyr Asp Glu Ile
  65                  70                  75                  80
 Ile Glu Leu Lys Lys Ser Leu His Val Gln Lys Ser Asp Val Asp Leu
                  85                  90                  95    
 Met Arg Thr Lys Leu Arg Arg Leu Glu Glu Glu Asn Ser Arg Lys Asp
             100                 105                 110        
 Arg Gln Ile Glu Gln Leu Leu Asp Pro Ser Arg Gly Thr Asp Phe Val
         115                 120                 125            
 Arg Thr Leu Ala Glu Lys Arg Pro Asp Ala Ser Trp Val Ile Asn Gly
     130                 135                 140                
 Leu Lys Gln Arg Ile Leu Lys Leu Glu Gln Gln Cys Lys Glu Lys Asp
 145                 150                 155                 160
 Gly Thr Ile Ser Lys Leu Gln Thr Asp Met Lys Thr Thr Asn Leu Glu
                 165                 170                 175    
 Glu Met Arg Ile Ala Met Glu Thr Tyr Tyr Glu Glu Val His Arg Leu
             180                 185                 190        
 Gln Thr Leu Leu Ala Ser Ser Glu Thr Thr Gly Lys Lys Pro Leu Gly
         195                 200                 205            
 Glu Lys Lys Thr Gly Ala Lys Arg Gln Lys Lys Met Gly Ser Ala Leu
     210                 215                 220                
 Leu Ser Leu Ser Arg Ser Val Gln Glu Leu Thr Glu Glu Asn Gln Ser
 225                 230                 235                 240
 Leu Lys Glu Asp Leu Asp Arg Val Leu Ser Thr Ser Pro Thr Ile Ser
                 245                 250                 255    
 Lys Thr Gln Gly Tyr Val Glu Trp Ser Lys Pro Arg Leu Leu Arg Arg
             260                 265                 270        
 Ile Val Glu Leu Glu Lys Lys Leu Ser Val Met Glu Ser Ser Lys Ser
         275                 280                 285            
 His Ala Ala Glu Pro Val Arg Ser His Pro Pro Ala Cys Leu Ala Ser
     290                 295                 300                
 Ser Ser Ala Leu His Arg Gln Pro Arg Gly Asp Arg Asn Lys Asp His
 305                 310                 315                 320
 Glu Arg Leu Arg Gly Ala Val Arg Asp Leu Lys Glu Glu Arg Thr Ala
                 325                 330                 335    
 Leu Gln Glu Gln Leu Leu Gln Arg Asp Leu Glu Val Lys Gln Leu Leu
             340                 345                 350        
 Gln Ala Lys Ala Asp Leu Glu Lys Glu Leu Glu Cys Ala Arg Glu Gly
         355                 360                 365            
 Glu Glu Glu Arg Arg Glu Arg Glu Glu Val Leu Arg Glu Glu Ile Gln
     370                 375                 380                
 Thr Leu Thr Ser Lys Leu Gln Glu Leu Gln Glu Met Lys Lys Glu Glu
 385                 390                 395                 400
 Lys Glu Asp Cys Pro Glu Val Pro His Lys Ala Gln Glu Leu Pro Ala
                 405                 410                 415    
 Pro Thr Pro Ser Ser Arg His Cys Glu Gln Asp Trp Pro Pro Asp Ser
             420                 425                 430        
 Ser Glu Glu Gly Leu Pro Arg Pro Arg Ser Pro Cys Ser Asp Gly Arg
         435                 440                 445            
 Arg Asp Ala Ala Ala Arg Val Leu Gln Ala Gln Trp Lys Val Tyr Lys
     450                 455                 460                
 His Lys Lys Lys Lys Ala Val Leu Asp Glu Ala Ala Val Val Leu Gln
 465                 470                 475                 480
 Ala Ala Phe Arg Gly His Leu Thr Arg Thr Lys Leu Leu Ala Ser Lys
                 485                 490                 495    
 Ala His Gly Ser Glu Pro Pro Ser Val Pro Gly Leu Pro Asp Gln Ser
             500                 505                 510        
 Ser Pro Val Pro Arg Val Pro Ser Pro Ile Ala Gln Ala Thr Gly Ser
         515                 520                 525            
 Pro Val Gln Glu Glu Ala Ile Val Ile Ile Gln Ser Ala Leu Arg Ala
     530                 535                 540                
 His Leu Ala Arg Ala Arg His Ser Ala Thr Gly Lys Arg Thr Thr Thr
 545                 550                 555                 560
 Ala Ala Ser Thr Arg Arg Arg Ser Ala Ser Ala Thr His Gly Asp Ala
                 565                 570                 575    
 Ser Ser Pro Pro Phe Leu Ala Ala Leu Pro Asp Pro Ser Pro Ser Gly
             580                 585                 590        
 Pro Gln Ala Val Ala Pro Leu Pro Gly Asp Asp Val Asn Ser Asp Asp
         595                 600                 605            
 Ser Asp Asp Ile Val Ile Ala Pro Ser Leu Pro Thr Lys Asn Phe Pro
     610                 615                 620                
 Val
 625



      <210> 1842
      <211> 90
      <212> PRT
      <213> Homo sapiens


      <400> 1842
 Met Phe Asn Phe Cys Phe Ser Ser Leu Ser Leu Ser Ser Phe Pro Leu
   1               5                  10                  15    
 Met Phe Thr Leu Leu Pro Phe Pro Trp Phe Leu Phe Glu Gln Pro Leu
              20                  25                  30        
 Asn Ser Ile Ser Leu Trp Arg Leu Pro Leu Phe Phe Leu Ser Gly Asp
          35                  40                  45            
 Ser Ser Leu Thr Ala Glu Gly Gly Met Asn Met Trp Phe Ala Phe Phe
      50                  55                  60                
 Val Ser Ala Ala Phe Gly Ser Ile Phe Phe Ile Ser Leu Glu Lys Leu
  65                  70                  75                  80
 Ser Cys Ser Ser Phe Arg Cys Leu Ala Lys
                  85                  90



      <210> 1843
      <211> 357
      <212> PRT
      <213> Homo sapiens


      <400> 1843
 Arg His Ser Ala Leu Gly Thr Gly Gly Ser Ser Ser Cys Arg Gln Gln
   1               5                  10                  15    
 Arg Pro Arg Asp Thr Trp Val Pro Glu Thr Thr Ile Leu Thr Ala Trp
              20                  25                  30        
 Ser Ser Arg Leu Gln Gln Leu Gly Pro Trp Leu Gln Val Thr Val Ala
          35                  40                  45            
 Gly Gln Val Asn Thr Leu Ala Gly Ile Gln Lys Thr Ile His Ala Glu
      50                  55                  60                
 His Cys Asn Val Thr Glu Arg Pro Pro Thr Gly His Glu Ala Leu Ala
  65                  70                  75                  80
 Pro Pro Cys Glu Gln Gly Pro Pro Gln Val Leu Asp Ser Asn Ala Val
                  85                  90                  95    
 Ala Pro Thr Ala Asp Cys Gly Tyr Gln Leu Ser Thr Ala Ile Asn Arg
             100                 105                 110        
 Asn Gln Glu Leu Cys Gly Arg Lys Pro Ala Val Ser Pro Ser Arg Gly
         115                 120                 125            
 Ile Ser Pro Gly Ser Pro Ile Leu Arg Pro Ala Val His Pro Gly His
     130                 135                 140                
 Tyr Cys Leu Gln Gln Arg Leu Ser Gly Gln Lys Ser Asn Arg Arg Thr
 145                 150                 155                 160
 Thr Gln Lys Ser Phe Gln Lys Leu His Val Asp Lys Arg Lys Pro Glu
                 165                 170                 175    
 Asn Phe Ser Lys Glu Ser Asp His Leu Leu Ile Tyr Ser Arg Glu Gly
             180                 185                 190        
 Asn Pro Asp Val Ala Ser Leu Ala Thr Pro Pro Gly Ile Trp Met Met
         195                 200                 205            
 Ser Ala Thr Asp Leu Phe Tyr Gly Asp Pro Phe Ala Phe Pro Gly Gly
     210                 215                 220                
 Gly Pro Phe Thr Leu Ser Leu Glu Arg Gly Pro Ser Val Ile Leu Gly
 225                 230                 235                 240
 Thr Asp Ala Ser Glu Glu Leu Leu Phe Thr Lys Ala Ser Leu Ala Val
                 245                 250                 255    
 Ser Thr Ser Val Phe Gln Phe Ser Thr Gly Lys Ile Tyr Thr Glu Trp
             260                 265                 270        
 Val Trp Gln Lys Asn Lys Ser Phe Leu Ser Pro His Phe Pro Thr Lys
         275                 280                 285            
 Pro Met Ala Ser Pro Val Lys Gly Lys His Ser Thr Ser Leu Leu Gln
     290                 295                 300                
 Arg Leu Asn Tyr Arg Asp Arg Trp Gln Cys Leu Gln Glu Gly Ala Gly
 305                 310                 315                 320
 Leu Ala Leu Leu Ser Ala His Met Lys Val Pro Thr Gly Ser Lys Glu
                 325                 330                 335    
 Pro Gln Gln Ala Gly Lys Leu Pro Ser Lys Pro Arg Lys Gln Thr Thr
             340                 345                 350        
 Pro Thr Phe Lys Asp
         355        



      <210> 1844
      <211> 130
      <212> PRT
      <213> Homo sapiens


      <400> 1844
 Gln Ser Arg Leu Ala Gln Ala Gly Leu Leu Gly Gly Pro Gly Asp Trp
   1               5                  10                  15    
 Ala Ser Ser Leu Gly Ser Cys Gln Arg Arg Arg Lys Lys Ser Cys Cys
              20                  25                  30        
 Gly Arg Cys Glu Glu Leu Arg Ser Glu Asn Asp Tyr Leu Lys Asp Glu
          35                  40                  45            
 Leu Asp Glu Leu Arg Ala Glu Met Glu Glu Met Arg Asp Ser Tyr Leu
      50                  55                  60                
 Glu Glu Asp Val Tyr Gln Leu Gln Glu Leu Arg Arg Glu Leu Asp Arg
  65                  70                  75                  80
 Ala Asn Lys Asn Cys Arg Ile Leu Gln Tyr Arg Leu Arg Lys Ala Glu
                  85                  90                  95    
 Gln Lys Ser Leu Lys Val Ala Glu Thr Gly Gln Val Asp Gly Glu Leu
             100                 105                 110        
 Ile Arg Ser Leu Glu Gln Asp Leu Lys Val Ala Lys Asp Val Ser Val
         115                 120                 125            
 Arg Leu
     130



      <210> 1845
      <211> 178
      <212> PRT
      <213> Homo sapiens


      <400> 1845
 Asn Ser Arg Val Asp Asp Phe Val Tyr Phe Cys Trp Gly Ala Asp Ser
   1               5                  10                  15    
 Arg Glu Leu Gln Arg Arg Arg Thr Ala Gly Ser Pro Gly Ala Glu Leu
              20                  25                  30        
 Leu Gln Ala Ala Ser Gly Glu Arg His Ser Leu Leu Leu Leu Thr Asn
          35                  40                  45            
 His Arg Val Leu Ser Cys Gly Asp Asn Ser Arg Gly Gln Leu Gly Arg
      50                  55                  60                
 Arg Gly Ala Gln Arg Gly Glu Leu Pro Gln Pro Ile Gln Ala Leu Glu
  65                  70                  75                  80
 Thr Leu Ile Val Asp Leu Val Ser Cys Gly Lys Glu His Ser Leu Ala
                  85                  90                  95    
 Val Cys His Lys Gly Arg Val Phe Ala Trp Gly Ala Gly Ser Glu Gly
             100                 105                 110        
 Gln Leu Gly Ile Gly Glu Phe Lys Glu Ile Ser Phe Thr Pro Lys Lys
         115                 120                 125            
 Ile Thr Thr Leu Asn Asp Ile Lys Ile Ile Gln Val Ser Cys Gly His
     130                 135                 140                
 Tyr His Ser Leu Ala Leu Ser Lys Asp Ser Gln Val Phe Ser Trp Gly
 145                 150                 155                 160
 Lys Asn Ser His Gly Gln Leu Gly Leu Gly Lys Glu Phe Pro Ser Gln
                 165                 170                 175    
 Ala Arg
        



      <210> 1846
      <211> 85
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(85)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1846
 Gln Met Cys Pro Thr Ser Tyr Arg Gly Asn Arg Ser Asn Asp Gln Gly
   1               5                  10                  15    
 Met Cys Phe Lys His Gln Glu Ala Leu Lys Leu Phe Cys Glu Val Asp
              20                  25                  30        
 Lys Glu Ala Ile Cys Val Val Cys Arg Glu Ser Arg Ser His Lys Gln
          35                  40                  45            
 His Ser Val Leu Pro Leu Glu Glu Val Val Gln Glu Tyr Gln Val Arg
      50                  55                  60                
 Glu Met Arg Glu Cys Gly Gly Met Lys Gly Val Glu Arg Xaa Leu Gly
  65                  70                  75                  80
 Glu Leu Arg Asn Glu
                  85



      <210> 1847
      <211> 614
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(614)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1847
 Tyr Ser Pro Arg Pro Arg Arg Arg Arg Lys Gly Arg Arg Ala Arg Arg
   1               5                  10                  15    
 Glu Val Gln Glu Gly Pro Ser Pro Trp Val His Gly Pro Arg Val Ala
              20                  25                  30        
 Glu Asp Thr Gly Leu Val Pro Asn Trp Leu Leu Leu Leu Pro Val Ala
          35                  40                  45            
 Ser Met Ala Glu Asp Trp Leu Asp Cys Pro Ala Leu Gly Pro Gly Trp
      50                  55                  60                
 Lys Arg Arg Glu Val Phe Arg Lys Ser Gly Ala Thr Cys Gly Arg Ser
  65                  70                  75                  80
 Asp Thr Tyr Tyr Gln Ser Pro Thr Gly Asp Arg Ile Arg Ser Lys Val
                  85                  90                  95    
 Glu Leu Thr Arg Tyr Leu Gly Pro Ala Cys Asp Leu Thr Leu Phe Asp
             100                 105                 110        
 Phe Lys Gln Gly Ile Leu Cys Tyr Pro Ala Pro Lys Ala His Pro Val
         115                 120                 125            
 Ala Val Ala Ser Lys Lys Arg Lys Lys Pro Ser Arg Pro Ala Lys Thr
     130                 135                 140                
 Arg Lys Arg Gln Val Gly Pro Gln Ser Gly Glu Val Arg Lys Glu Ala
 145                 150                 155                 160
 Pro Arg Asp Glu Thr Lys Ala Asp Thr Asp Thr Ala Pro Ala Ser Phe
                 165                 170                 175    
 Pro Ala Pro Gly Cys Cys Glu Asn Cys Gly Ile Ser Phe Ser Gly Asp
             180                 185                 190        
 Gly Thr Gln Arg Gln Arg Leu Lys Thr Leu Cys Lys Asp Cys Arg Ala
         195                 200                 205            
 Gln Arg Ile Ala Phe Asn Arg Glu Gln Arg Met Phe Lys Ser Arg Gly
     210                 215                 220                
 Cys Gly Val Cys Arg Gly Cys Gln Thr Gln Glu Asp Cys Gly His Cys
 225                 230                 235                 240
 Pro Ile Cys Leu Arg Pro Pro Arg Pro Gly Leu Arg Arg Gln Trp Lys
                 245                 250                 255    
 Cys Val Gln Arg Arg Cys Leu Arg Gly Lys His Ala Arg Arg Lys Gly
             260                 265                 270        
 Gly Cys Asp Ser Lys Met Ala Ala Arg Arg Arg Pro Gly Ala Gln Pro
         275                 280                 285            
 Leu Pro Pro Pro Pro Pro Ser Gln Ser Pro Glu Pro Thr Glu Pro His
     290                 295                 300                
 Pro Arg Ala Leu Ala Pro Ser Pro Pro Ala Glu Phe Ile Tyr Tyr Cys
 305                 310                 315                 320
 Val Asp Glu Asp Glu Leu Gln Pro Tyr Thr Asn Arg Arg Gln Asn Arg
                 325                 330                 335    
 Lys Cys Gly Ala Cys Ala Ala Cys Leu Arg Arg Asn Gly Cys Gly Arg
             340                 345                 350        
 Cys Asp Phe Cys Cys Asp Lys Pro Lys Phe Gly Gly Ser Asn Gln Lys
         355                 360                 365            
 Arg Gln Lys Cys Arg Trp Arg Gln Cys Leu Gln Phe Ala Met Lys Arg
     370                 375                 380                
 Leu Leu Pro Ser Val Trp Ser Glu Ser Glu Asp Gly Ala Gly Ser Pro
 385                 390                 395                 400
 Pro Pro Tyr Arg Arg Arg Lys Arg Pro Ser Ser Ala Arg Arg His His
                 405                 410                 415    
 Leu Gly Pro Thr Leu Lys Pro Thr Leu Ala Thr Arg Thr Ala Gln Pro
             420                 425                 430        
 Asp His Thr Gln Ala Pro Thr Lys Gln Glu Ala Gly Gly Gly Phe Val
         435                 440                 445            
 Leu Pro Pro Pro Gly His Xaa Thr Leu Cys Phe Leu Arg Glu Gly Ala
     450                 455                 460                
 Ser Ser Pro Val Gln Val Pro Gly Pro Val Ala Ala Ser Thr Glu Ala
 465                 470                 475                 480
 Leu Leu Gln Glu Ala Gln Cys Ser Gly Met Ser Trp Val Val Ala Leu
                 485                 490                 495    
 Pro Gln Val Lys Gln Glu Lys Ala Asp Thr Gln Asp Glu Trp Thr Pro
             500                 505                 510        
 Gly Thr Ala Val Leu Thr Ser Pro Val Leu Val Pro Gly Cys Pro Ser
         515                 520                 525            
 Lys Ala Val Asp Pro Gly Leu Pro Ser Val Lys Gln Glu Pro Pro Asp
     530                 535                 540                
 Pro Glu Glu Asp Lys Glu Glu Asn Lys Asp Asp Ser Ala Ser Lys Leu
 545                 550                 555                 560
 Ala Pro Glu Glu Glu Ala Gly Gly Ala Gly Thr Pro Val Ile Thr Glu
                 565                 570                 575    
 Ile Phe Ser Leu Gly Gly Thr Arg Phe Arg Asp Thr Ala Val Trp Leu
             580                 585                 590        
 Pro Arg Ser Lys Asp Leu Lys Lys Pro Gly Ala Arg Lys Gln Leu Thr
         595                 600                 605            
 Gly Gly Phe Tyr Arg Leu
     610                



      <210> 1848
      <211> 46
      <212> PRT
      <213> Homo sapiens


      <400> 1848
 Arg Met His Val Asp Pro Val Gly Trp Ile Leu Thr Thr Glu Cys Phe
   1               5                  10                  15    
 Gln Val Pro Gln Gln Lys Ala Met Ala Pro Leu His Pro His Pro Ala
              20                  25                  30        
 Gly Met Arg Ile Asn Val Val Asn Asn His Gln Ala Val Tyr
          35                  40                  45    



      <210> 1849
      <211> 113
      <212> PRT
      <213> Homo sapiens


      <400> 1849
 Val Thr Gly Ala Ala Asn Val Ala Lys Gly Ala Val Gln Gly Gly Leu
   1               5                  10                  15    
 Asp Thr Thr Lys Ser Val Leu Thr Gly Thr Lys Asp Ala Val Ser Thr
              20                  25                  30        
 Gly Leu Thr Gly Ala Val Asn Val Ala Lys Gly Thr Val Gln Thr Gly
          35                  40                  45            
 Val Asp Thr Thr Lys Thr Val Leu Thr Gly Thr Lys Asp Thr Val Cys
      50                  55                  60                
 Ser Gly Val Thr Ser Ala Val Asn Val Ala Lys Gly Ala Val Gln Gly
  65                  70                  75                  80
 Gly Leu Asp Thr Thr Lys Ser Val Val Ile Gly Thr Lys Asp Thr Met
                  85                  90                  95    
 Ser Thr Gly Leu Thr Gly Ala Ala Asn Val Ala Lys Gly Ser Thr Arg
             100                 105                 110        
 Pro
    



      <210> 1850
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 1850
 Arg His Glu Ala Gly Ser Arg Glu His Gly Gly Ala Val Glu Gly Val
   1               5                  10                  15    
 Thr Gly Phe Arg Arg Leu Ala Ser Gly Ser Ala Val Cys Ser Leu Ala
              20                  25                  30        
 Ala Gly Leu Arg Val Gly Arg Leu Arg Arg Leu Leu Pro Leu Gln Phe
          35                  40                  45            
 Ser Arg Cys Gly His Glu Ser Gly Cys Thr Ala Val Ile His Pro His
      50                  55                  60                
 Leu Leu Lys Met His Pro Asp Leu Ser Pro His Leu His Thr Glu Glu
  65                  70                  75                  80
 Cys Asn Val Leu Ile Asn Leu Leu Lys Glu Cys His Lys Asn His Asn
                  85                  90                  95    
 Ile Leu Lys Phe Phe Gly Tyr Cys Asn Asp Val Asp Arg Glu Leu Arg
             100                 105                 110        
 Lys Cys Leu Lys Asn Glu Tyr Val Glu Asn Arg Thr Lys Ser Arg Glu
         115                 120                 125            
 His Gly Ile Ala Met Arg Lys Lys Leu Phe Asn Pro Pro Glu Glu Ser
     130                 135                 140                
 Glu Lys
 145    



      <210> 1851
      <211> 178
      <212> PRT
      <213> Homo sapiens


      <400> 1851
 Lys Arg Arg Gly Ser Phe Lys Met Ala Glu Leu Asp Gln Leu Pro Asp
   1               5                  10                  15    
 Glu Ser Ser Ser Ala Lys Ala Leu Val Ser Leu Lys Glu Gly Ser Leu
              20                  25                  30        
 Ser Asn Thr Trp Asn Glu Lys Tyr Ser Ser Leu Gln Lys Thr Pro Val
          35                  40                  45            
 Trp Lys Gly Arg Asn Thr Ser Ser Ala Val Glu Met Pro Phe Arg Asn
      50                  55                  60                
 Ser Lys Arg Ser Arg Leu Phe Ser Asp Glu Asp Asp Arg Gln Ile Asn
  65                  70                  75                  80
 Thr Arg Ser Pro Lys Arg Asn Gln Arg Val Ala Met Val Pro Gln Lys
                  85                  90                  95    
 Phe Thr Ala Thr Met Ser Thr Pro Asp Lys Lys Ala Ser Gln Lys Ile
             100                 105                 110        
 Gly Phe Arg Leu Arg Asn Leu Leu Lys Leu Pro Lys Ala His Lys Trp
         115                 120                 125            
 Cys Ile Tyr Glu Trp Phe Tyr Ser Asn Ile Asp Lys Pro Leu Phe Glu
     130                 135                 140                
 Gly Asp Asn Asp Phe Cys Val Cys Leu Lys Glu Ser Phe Pro Asn Leu
 145                 150                 155                 160
 Lys Thr Arg Lys Leu Thr Arg Val Glu Trp Gly Lys Ile Arg Arg Leu
                 165                 170                 175    
 Met Gly
        



      <210> 1852
      <211> 56
      <212> PRT
      <213> Homo sapiens


      <400> 1852
 Ala Cys Arg Gly Asp Ser Gly Gly Pro Leu Val Thr Arg Asp Leu Lys
   1               5                  10                  15    
 Asp Thr Trp Tyr Leu Ile Gly Ile Val Ser Trp Gly Asp Asn Cys Gly
              20                  25                  30        
 Gln Lys Asp Lys Pro Gly Val Tyr Thr Gln Val Thr Tyr Tyr Arg Asn
          35                  40                  45            
 Trp Ile Ala Ser Lys Thr Gly Ile
      50                  55    



      <210> 1853
      <211> 56
      <212> PRT
      <213> Homo sapiens


      <400> 1853
 Ala Cys Arg Gly Asp Ser Gly Gly Pro Leu Val Thr Arg Asp Leu Lys
   1               5                  10                  15    
 Asp Thr Trp Tyr Leu Ile Gly Ile Val Ser Trp Gly Asp Asn Cys Gly
              20                  25                  30        
 Gln Lys Asp Lys Pro Gly Val Tyr Thr Gln Val Thr Tyr Tyr Arg Asn
          35                  40                  45            
 Trp Ile Ala Ser Lys Thr Gly Ile
      50                  55    



      <210> 1854
      <211> 289
      <212> PRT
      <213> Homo sapiens


      <400> 1854
 Met Glu Pro Ser Lys Thr Phe Met Arg Asn Leu Pro Ile Thr Pro Gly
   1               5                  10                  15    
 Tyr Ser Gly Phe Val Pro Phe Leu Ser Cys Gln Gly Met Ser Lys Glu
              20                  25                  30        
 Asp Asp Met Asn His Cys Val Lys Thr Phe Gln Glu Lys Thr Gln Arg
          35                  40                  45            
 Tyr Lys Glu Gln Leu Arg Glu Leu Cys Cys Ala Val Ala Thr Ala Pro
      50                  55                  60                
 Lys Leu Lys Pro Val Asn Ser Glu Glu Thr Val Leu Gln Ala Leu His
  65                  70                  75                  80
 Gln Tyr Asn Leu Gln Tyr His Pro Leu Ile Leu Gly Ser Ser Ala Leu
                  85                  90                  95    
 Lys Pro Phe Pro Leu Thr Pro Glu Cys Lys Tyr Val Lys Lys Pro Leu
             100                 105                 110        
 Gln Glu Pro Pro Ile Pro Gly Trp Ala Gly Tyr Leu Pro Arg Ala Lys
         115                 120                 125            
 Val Thr Glu Phe Gly Cys Gly Thr Arg Tyr Thr Val Met Ala Lys Asn
     130                 135                 140                
 Cys Tyr Lys Asp Phe Leu Glu Ile Thr Glu Arg Ala Lys Lys Ala His
 145                 150                 155                 160
 Leu Lys Pro Tyr Glu Glu Ile Tyr Gly Val Ser Ser Thr Lys Thr Ser
                 165                 170                 175    
 Ala Pro Ser Pro Lys Val Leu Gln His Glu Glu Leu Leu Pro Lys Tyr
             180                 185                 190        
 Pro Asp Phe Ser Ile Pro Asp Asp His Thr Ser Ser Pro Ala Met Val
         195                 200                 205            
 Leu Asn Gln Ile Glu Met Ala Glu Met Ser Asp Ile Glu Phe Arg Ile
     210                 215                 220                
 Trp Met Ala Arg Lys Leu Asn Glu Thr Gln Glu Lys Val Glu Thr Gln
 225                 230                 235                 240
 Ser Lys Glu Asn Asn Lys Met Ile Gln Gly Leu Lys Asp Asp Ile Thr
                 245                 250                 255    
 Ile Leu Arg Lys Asn Gln Asn Glu Leu Leu Glu Ile Glu Asn Leu Gln
             260                 265                 270        
 Glu Phe His Asn Thr Ile Gly Ser Ile Asn Asn Asn Trp Asn Arg Pro
         275                 280                 285            
 Thr
    



      <210> 1855
      <211> 58
      <212> PRT
      <213> Homo sapiens


      <400> 1855
 Met Gly Asn Gln Glu Val Ser Leu Glu Asn Gln Gln Ala Lys Asn Ser
   1               5                  10                  15    
 Lys Lys Glu Arg Leu Leu Gly Ser Ala Ser Ser Glu Asp Ile Trp Arg
              20                  25                  30        
 Asn Tyr Ser Leu Asp Glu Ile Glu Arg Asn Phe Cys Leu Gln Val Arg
          35                  40                  45            
 Cys Phe Pro Lys Pro Gln Leu Pro Thr Glu
      50                  55            



      <210> 1856
      <211> 549
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(549)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1856
 Ser Ala Pro Ala Gln Leu Pro Glu Ala Leu Val Gly Pro Gln Thr Ser
   1               5                  10                  15    
 Leu Ala Lys Leu Pro Arg Pro Ser Ser Gly Leu Thr Val Ala Ser Pro
              20                  25                  30        
 Gly Ser Ala Thr Cys Pro Pro Met Ala Ser Ala Gly Pro Lys Arg Pro
          35                  40                  45            
 Pro Val Gly Gly Leu Leu Xaa Ala Gln Leu Gly Pro Pro Gly Gly Pro
      50                  55                  60                
 Ala Gly Pro Asn Arg Pro Glu Val Gly Leu Ser Arg Pro Ser Ser Gly
  65                  70                  75                  80
 Leu Pro Ala Ala Ser Ala Gly Pro Ser Arg Pro Pro Ser Arg Pro Gly
                  85                  90                  95    
 Ser Gly Pro Gly Arg Ala Ala Ser Arg Pro Pro Arg Ala Gln Pro Val
             100                 105                 110        
 Leu Ser Ala Ala Ser Pro Gly Ala Lys Leu Pro Arg Val Ser Leu Ser
         115                 120                 125            
 Arg Pro Ser Ser Ser Cys Leu Pro Val Ala Ser Phe Gly Pro Ala Gln
     130                 135                 140                
 Leu Met Pro Leu Gly Gly Leu Pro Arg Pro Arg Phe Xaa Leu Leu Ala
 145                 150                 155                 160
 Ala Ser Ala Gly Leu Asp Lys Ala Arg Pro Pro Ala Ser Arg Arg Pro
                 165                 170                 175    
 Ala Gln Ala Gln Pro Leu Pro His Ser Arg Pro Pro Arg Pro Ala Ser
             180                 185                 190        
 Ser Pro Pro His Cys Gly Leu Pro Ser Pro Lys Leu Leu Pro Leu Gly
         195                 200                 205            
 Arg Phe Gly Arg Pro Ser Ser Arg Leu Pro Gly Pro Leu Gln Ala His
     210                 215                 220                
 Gly Ala His Ser Ser Gln Arg Pro Ser Arg Pro Ser Phe Ser Leu Pro
 225                 230                 235                 240
 Ala Ala Ser Pro Gly Pro Glu Pro Pro Gln Val Gly Leu Ser Arg Pro
                 245                 250                 255    
 Thr Cys Ser Leu Pro Ala Ser Ser Pro Gly Pro Ala Leu Pro Pro Gly
             260                 265                 270        
 Cys Val Ser Arg Pro Asp Phe Gly Leu Pro Thr Thr Ser Leu Asp Ser
         275                 280                 285            
 Ala Pro Ala Gln Leu Pro Val Ala Leu Val Gly Pro Gln Leu Pro Lys
     290                 295                 300                
 Ala Lys Leu Pro Arg Pro Ser Ser Gly Leu Thr Val Ala Ser Pro Gly
 305                 310                 315                 320
 Ser Ala Thr Cys Pro Pro Met Ala Ser Ala Gly Pro Lys Arg Pro Pro
                 325                 330                 335    
 Val Gly Gly Leu Leu Xaa Ala Gln Leu Gly Pro Pro Gly Gly Pro Ala
             340                 345                 350        
 Gly Pro Asn Arg Pro Glu Val Gly Leu Ser Arg Pro Ser Ser Ser Leu
         355                 360                 365            
 Pro Ala Val Ser Ala Gly Pro Ser Arg Pro Pro Ser Arg Pro Gly Ile
     370                 375                 380                
 Gly Pro Gly Arg Ala Ala Ser Arg Pro Pro Arg Ala Gln Leu Arg Pro
 385                 390                 395                 400
 Pro Ala Ala Ser Pro Gly Ala Lys Leu Pro Arg Val Ser Leu Ser Arg
                 405                 410                 415    
 Pro Ser Ser Ser Trp Pro Pro Ser Gly Leu Phe Arg Pro Ser Pro Ala
             420                 425                 430        
 His Gly Ser Arg Leu Pro Ser Gln Ala Pro Ala Phe Asp Phe Trp Gln
         435                 440                 445            
 Pro Leu Gln Ala Gln Asn Leu Ile Ser Ser Arg Pro Leu Gln Ala Arg
     450                 455                 460                
 Pro Pro Ala Ser Gln Arg Pro Ala Arg Ala Arg Pro Trp Pro Trp Pro
 465                 470                 475                 480
 His Ser Gly Leu Ser Thr Pro Ser Xaa Leu Ser Pro His Cys Gly Leu
                 485                 490                 495    
 Pro Arg Pro Lys Leu Leu Pro Phe Gly His Phe Gly Arg Ser Ser Tyr
             500                 505                 510        
 Cys Leu Pro Val Ala Ser Leu Gly Pro Ala His Ser Ser Arg Arg Pro
         515                 520                 525            
 Phe Gln Ala Pro Phe Phe Pro Ser Gly Ser Leu Leu Ala Ser Asn Leu
     530                 535                 540                
 Phe Ile Phe Cys Val
 545                



      <210> 1857
      <211> 210
      <212> PRT
      <213> Homo sapiens


      <400> 1857
 Pro Gly Arg Pro Thr Arg Pro Pro Thr Arg Ser Val Cys Gly Phe Phe
   1               5                  10                  15    
 Gly Gln Gly Ala Glu Gly Arg Leu Leu Ala Cys Ser Gln Gly Gly Gln
              20                  25                  30        
 Cys Tyr His Pro Tyr Cys Val Ser Ile Lys Ile Thr Lys Val Val Leu
          35                  40                  45            
 Ser Lys Gly Trp Arg Cys Leu Glu Cys Thr Val Cys Glu Ala Cys Gly
      50                  55                  60                
 Lys Ala Thr Asp Pro Gly Arg Leu Leu Leu Cys Asp Asp Cys Asp Ile
  65                  70                  75                  80
 Ser Tyr His Thr Tyr Cys Leu Asp Pro Pro Leu Gln Thr Val Pro Lys
                  85                  90                  95    
 Gly Gly Trp Lys Cys Lys Trp Cys Val Trp Cys Arg His Cys Gly Ala
             100                 105                 110        
 Thr Ser Ala Gly Leu Arg Cys Glu Trp Gln Asn Asn Tyr Thr Gln Cys
         115                 120                 125            
 Ala Pro Cys Ala Ser Leu Ser Ser Cys Pro Val Cys Tyr Arg Asn Tyr
     130                 135                 140                
 Arg Glu Glu Asp Leu Ile Leu Gln Cys Arg Gln Cys Asp Arg Trp Met
 145                 150                 155                 160
 His Ala Val Cys Gln Asn Leu Asn Thr Glu Glu Glu Val Glu Asn Val
                 165                 170                 175    
 Ala His Ile Gly Phe Asp Cys Ser Met Cys Arg Pro Tyr Met Pro Ala
             180                 185                 190        
 Ser Asn Val Pro Ser Ser Asp Cys Cys Glu Ser Ser Leu Val Ala Gln
         195                 200                 205            
 Ile Val
     210



      <210> 1858
      <211> 210
      <212> PRT
      <213> Homo sapiens


      <400> 1858
 Pro Gly Arg Pro Thr Arg Pro Pro Thr Arg Ser Val Cys Gly Phe Phe
   1               5                  10                  15    
 Gly Gln Gly Ala Glu Gly Arg Leu Leu Ala Cys Ser Gln Gly Gly Gln
              20                  25                  30        
 Cys Tyr His Pro Tyr Cys Val Ser Ile Lys Ile Thr Lys Val Val Leu
          35                  40                  45            
 Ser Lys Gly Trp Arg Cys Leu Glu Cys Thr Val Cys Glu Ala Cys Gly
      50                  55                  60                
 Lys Ala Thr Asp Pro Gly Arg Leu Leu Leu Cys Asp Asp Cys Asp Ile
  65                  70                  75                  80
 Ser Tyr His Thr Tyr Cys Leu Asp Pro Pro Leu Gln Thr Val Pro Lys
                  85                  90                  95    
 Gly Gly Trp Lys Cys Lys Trp Cys Val Trp Cys Arg His Cys Gly Ala
             100                 105                 110        
 Thr Ser Ala Gly Leu Arg Cys Glu Trp Gln Asn Asn Tyr Thr Gln Cys
         115                 120                 125            
 Ala Pro Cys Ala Ser Leu Ser Ser Cys Pro Val Cys Tyr Arg Asn Tyr
     130                 135                 140                
 Arg Glu Glu Asp Leu Ile Leu Gln Cys Arg Gln Cys Asp Arg Trp Met
 145                 150                 155                 160
 His Ala Val Cys Gln Asn Leu Asn Thr Glu Glu Glu Val Glu Asn Val
                 165                 170                 175    
 Ala His Ile Gly Phe Asp Cys Ser Met Cys Arg Pro Tyr Met Pro Ala
             180                 185                 190        
 Ser Asn Val Pro Ser Ser Asp Cys Cys Glu Ser Ser Leu Val Ala Gln
         195                 200                 205            
 Ile Val
     210



      <210> 1859
      <211> 218
      <212> PRT
      <213> Homo sapiens


      <400> 1859
 Pro Phe Lys Lys Met Thr Asp Leu Leu Arg Ser Val Val Thr Val Ile
   1               5                  10                  15    
 Asp Val Phe Tyr Lys Tyr Thr Lys Gln Asp Gly Glu Cys Gly Thr Leu
              20                  25                  30        
 Ser Lys Gly Glu Leu Lys Glu Leu Leu Glu Lys Glu Leu His Pro Val
          35                  40                  45            
 Leu Lys Asn Pro Asp Asp Pro Asp Thr Val Asp Val Ile Met His Met
      50                  55                  60                
 Leu Asp Arg Asp His Asp Arg Arg Leu Asp Phe Thr Glu Phe Leu Leu
  65                  70                  75                  80
 Met Ile Phe Lys Leu Thr Met Ala Cys Asn Lys Val Leu Ser Lys Glu
                  85                  90                  95    
 Tyr Cys Lys Ala Ser Gly Ser Lys Lys His Arg Arg Gly His Arg His
             100                 105                 110        
 Gln Glu Glu Glu Ser Glu Thr Glu Glu Asp Glu Glu Asp Thr Pro Gly
         115                 120                 125            
 His Lys Ser Gly Tyr Arg His Ser Ser Trp Ser Glu Gly Glu Glu His
     130                 135                 140                
 Gly Tyr Ser Ser Gly His Ser Arg Gly Thr Val Lys Cys Arg His Gly
 145                 150                 155                 160
 Ser Asn Ser Arg Arg Leu Gly Arg Gln Gly Asn Leu Ser Ser Ser Gly
                 165                 170                 175    
 Asn Gln Glu Gly Ser Gln Lys Arg Tyr His Arg Ser Ser Cys Gly His
             180                 185                 190        
 Ser Trp Ser Gly Gly Lys Asp Arg His Gly Ser Ser Ser Val Glu Leu
         195                 200                 205            
 Arg Glu Arg Ile Asn Lys Ser His Ile Lys
     210                 215            



      <210> 1860
      <211> 136
      <212> PRT
      <213> Homo sapiens


      <400> 1860
 Glu Ile Cys Gly Ile Gln Gln Arg Leu Ala Leu Pro Val Trp Arg Pro
   1               5                  10                  15    
 Arg Asp Phe Glu Glu Glu Leu Ala Asp Cys Thr Ala Glu Leu Gly Glu
              20                  25                  30        
 Thr Val Lys Leu Ala Cys Arg Val Thr Gly Thr Pro Lys Pro Val Ile
          35                  40                  45            
 Ser Trp Tyr Lys Asp Gly Lys Ala Val Gln Val Asp Pro His His Ile
      50                  55                  60                
 Leu Ile Glu Asp Pro Asp Gly Ser Cys Ala Leu Ile Leu Asp Ser Leu
  65                  70                  75                  80
 Thr Gly Val Asp Ser Gly Gln Tyr Met Cys Phe Ala Ala Ser Ala Ala
                  85                  90                  95    
 Gly Asn Cys Ser Thr Leu Gly Lys Ile Leu Val Gln Val Pro Pro Arg
             100                 105                 110        
 Phe Val Asn Lys Val Arg Ala Ser Pro Phe Val Glu Gly Glu Asp Ala
         115                 120                 125            
 Gln Phe Thr Cys Thr Ile Glu Gly
     130                 135    



      <210> 1861
      <211> 65
      <212> PRT
      <213> Homo sapiens


      <400> 1861
 Val Ala Arg Gly Arg Pro Val Asp Glu Cys Cys Arg Pro Gln Ala Gln
   1               5                  10                  15    
 Cys Pro Val Ser Pro Ser Cys Thr His Glu Leu Arg Cys Ala Pro Thr
              20                  25                  30        
 Gln Glu Val Asp Ala Ser Glu Ile Gln Val Gln Val Cys Leu Tyr Ala
          35                  40                  45            
 Phe Asp Leu Ile Tyr Leu Asn Gly Glu Val Ser Ser Ser Phe Leu Pro
      50                  55                  60                
 Leu
  65



      <210> 1862
      <211> 275
      <212> PRT
      <213> Homo sapiens


      <400> 1862
 Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys Leu
   1               5                  10                  15    
 Glu Phe Ser Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser
              20                  25                  30        
 Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser
          35                  40                  45            
 Glu Ser Asp Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln
      50                  55                  60                
 Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr
  65                  70                  75                  80
 Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser
                  85                  90                  95    
 Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Ala Ala Met Tyr Phe Cys
             100                 105                 110        
 Ala Tyr Arg Ser Gly Arg Asp Asp Lys Ile Ile Phe Gly Lys Gly Thr
         115                 120                 125            
 Arg Leu His Ile Leu Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr
     130                 135                 140                
 Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr
 145                 150                 155                 160
 Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val
                 165                 170                 175    
 Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys
             180                 185                 190        
 Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala
         195                 200                 205            
 Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser
     210                 215                 220                
 Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr
 225                 230                 235                 240
 Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile
                 245                 250                 255    
 Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu
             260                 265                 270        
 Trp Ser Ser
         275



      <210> 1863
      <211> 328
      <212> PRT
      <213> Homo sapiens


      <400> 1863
 Ile Arg Ala Leu Asp Leu Ala Gly Asp Pro Thr Ser Tyr Lys Thr Leu
   1               5                  10                  15    
 Gln Lys Cys Pro Ser Thr Glu Pro Glu Glu Lys Gly Asn Ile Val Glu
              20                  25                  30        
 Glu Gln Pro Gln Lys Asn Thr Thr Glu Lys Leu Gly Val Ser Ala Pro
          35                  40                  45            
 Thr Ile Pro Val Arg Arg Arg Leu Ala Trp Asp Thr Glu Asn Thr Ser
      50                  55                  60                
 Glu Asp Val Gln Lys Gln Pro Gly Glu Lys Glu Glu Glu Asp Asp Asn
  65                  70                  75                  80
 Glu Glu Glu Gly Asp Arg Lys Thr Gly Lys Gln Ala Phe Met Gly Glu
                  85                  90                  95    
 Gln Glu Lys Leu Asp Val His Glu Lys Ser Lys Ala Asp Lys Met Lys
             100                 105                 110        
 Glu Gly Ser Asp Ser Ser Val Ser Ser Glu Lys Gly Gly Arg Leu Pro
         115                 120                 125            
 Thr Pro Lys Leu Arg Glu Leu Gly Gly Ile Gln Arg Thr His His Asp
     130                 135                 140                
 Leu Thr Thr Pro Ala Val Gly Gly Ala Val Leu Val Ser Pro Ser Lys
 145                 150                 155                 160
 Met Lys Pro Pro Ala Pro Glu Gln Arg Lys Arg Met Thr Ser Gln Asp
                 165                 170                 175    
 Cys Leu Glu Thr Ser Lys Asn Asp Phe Thr Lys Lys Glu Ser Arg Ala
             180                 185                 190        
 Val Ser Leu Leu Thr Ser Pro Ala Ala Gly Ile Lys Thr Val Asp Pro
         195                 200                 205            
 Leu Pro Leu Arg Glu Asp Ser Glu Asp Asn Ile His Lys Phe Ala Glu
     210                 215                 220                
 Ala Thr Leu Pro Val Ser Lys Ile Pro Lys Tyr Pro Thr Asn Pro Pro
 225                 230                 235                 240
 Gly Gln Leu Pro Ser Pro Pro His Val Pro Ser Tyr Trp His Pro Ser
                 245                 250                 255    
 Arg Arg Ile Gln Gly Ser Leu Arg Asp Pro Glu Phe Gln His Asn Val
             260                 265                 270        
 Gly Lys Ala Arg Met Asn Asn Leu Gln Leu Pro Gln His Glu Ala Phe
         275                 280                 285            
 Asn Asp Glu Asp Glu Asp Arg Leu Ser Glu Ile Ser Ala Arg Ser Ala
     290                 295                 300                
 Ala Ser Ser Leu Arg Ala Phe Gln Thr Leu Ala Arg Ala Lys Lys Arg
 305                 310                 315                 320
 Lys Glu Asn Phe Trp Gly Lys Thr
                 325            



      <210> 1864
      <211> 62
      <212> PRT
      <213> Homo sapiens


      <400> 1864
 Leu Ser Phe Cys Ser Pro Ser Thr Thr Ala Val Cys Arg Cys Arg Arg
   1               5                  10                  15    
 Pro Ala Ala Asp Cys His Pro Ser Gly Ser Gly Arg Val Ser Thr Val
              20                  25                  30        
 Leu Leu Ile Gln Met Arg His Pro Leu Pro Leu Pro Ile Arg Leu Lys
          35                  40                  45            
 Ala Cys His Cys Ser Cys Thr Ala Arg Cys Pro Gly Leu Ser
      50                  55                  60        



      <210> 1865
      <211> 236
      <212> PRT
      <213> Homo sapiens


      <400> 1865
 Ser Pro Leu Gly Lys Glu Gly Gln Glu Glu Val Arg Val Lys Ile Lys
   1               5                  10                  15    
 Asp Leu Asn Glu His Ile Val Cys Cys Leu Cys Ala Gly Tyr Phe Val
              20                  25                  30        
 Asp Ala Thr Thr Ile Thr Glu Cys Leu His Thr Phe Cys Lys Ser Cys
          35                  40                  45            
 Ile Val Lys Tyr Leu Gln Thr Ser Lys Tyr Cys Pro Met Cys Asn Ile
      50                  55                  60                
 Lys Ile His Glu Thr Gln Pro Leu Leu Asn Leu Lys Leu Asp Arg Val
  65                  70                  75                  80
 Met Gln Asp Ile Val Tyr Lys Leu Val Pro Gly Leu Gln Asp Ser Glu
                  85                  90                  95    
 Glu Lys Arg Ile Arg Glu Phe Tyr Gln Ser Arg Gly Leu Asp Arg Val
             100                 105                 110        
 Thr Gln Pro Thr Gly Glu Glu Pro Ala Leu Ser Asn Leu Gly Leu Pro
         115                 120                 125            
 Phe Ser Ser Phe Asp His Ser Lys Ala His Tyr Tyr Arg Tyr Asp Glu
     130                 135                 140                
 Gln Leu Asn Leu Cys Leu Glu Arg Leu Ser Ser Gly Lys Asp Lys Asn
 145                 150                 155                 160
 Lys Ser Val Leu Gln Asn Lys Tyr Val Arg Cys Ser Val Arg Ala Glu
                 165                 170                 175    
 Val Arg His Leu Arg Arg Val Leu Cys His Arg Leu Met Leu Asn Pro
             180                 185                 190        
 Gln His Val Gln Leu Leu Phe Asp Asn Glu Val Leu Pro Asp His Met
         195                 200                 205            
 Thr Met Lys Gln Ile Trp Leu Ser Arg Trp Phe Gly Lys Pro Ser Pro
     210                 215                 220                
 Leu Leu Leu Gln Tyr Ser Val Lys Glu Lys Arg Arg
 225                 230                 235    



      <210> 1866
      <211> 233
      <212> PRT
      <213> Homo sapiens


      <400> 1866
 Ala Pro Trp Pro Leu Pro Leu Leu Arg Ser Pro Gln Ser Arg Pro His
   1               5                  10                  15    
 Ser Leu Gly Ser Leu Phe Pro Ser Leu Pro Gly Leu Ala Glu Leu Asp
              20                  25                  30        
 Leu Gln Arg Thr Leu Ser Leu Gln Ala Pro Pro Val Lys Glu Gly Pro
          35                  40                  45            
 Leu Phe Ile His Arg Thr Lys Gly Lys Gly Pro Leu Met Ser Ser Ser
      50                  55                  60                
 Phe Lys Lys Leu Tyr Phe Ser Leu Thr Thr Glu Ala Leu Ser Phe Ala
  65                  70                  75                  80
 Lys Thr Pro Ser Ser Lys Cys Val Asn Glu Leu Asn Gln Trp Leu Ser
                  85                  90                  95    
 Ala Leu Arg Lys Val Ser Ile Asn Asn Thr Gly Leu Leu Gly Ser Tyr
             100                 105                 110        
 His Pro Gly Val Phe Arg Gly Asp Lys Trp Ser Cys Cys His Gln Lys
         115                 120                 125            
 Glu Lys Thr Gly Gln Gly Cys Asp Lys Thr Arg Ser Arg Val Thr Leu
     130                 135                 140                
 Gln Glu Trp Asn Asp Pro Leu Asp His Asp Leu Glu Ala Gln Leu Ile
 145                 150                 155                 160
 Tyr Arg His Leu Leu Gly Val Glu Ala Met Leu Trp Glu Arg His Arg
                 165                 170                 175    
 Glu Leu Ser Gly Gly Ala Glu Ala Gly Thr Val Pro Thr Ser Pro Gly
             180                 185                 190        
 Lys Val Pro Glu Asp Ser Leu Ala Arg Leu Leu Arg Val Leu Gln Asp
         195                 200                 205            
 Leu Arg Glu Ala His Ser Ser Ser Pro Ala Gly Ser Pro Pro Ser Glu
     210                 215                 220                
 Pro Asn Cys Leu Leu Glu Leu Gln Thr
 225                 230            



      <210> 1867
      <211> 260
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(260)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1867
 Phe Arg Arg Met Pro Ser Gln Pro Ser Ser Gly Gln Tyr Pro Pro Ser
   1               5                  10                  15    
 Thr Val Asn Met Gly Gln Tyr Tyr Lys Pro Glu Gln Phe Asn Gly Gln
              20                  25                  30        
 Asn Asn Thr Phe Ser Gly Ser Ser Tyr Ser Asn Tyr Ser Gln Gly Asn
          35                  40                  45            
 Val Asn Arg Pro Pro Arg Pro Val Ala Val Ala Asn Tyr Pro His Ser
      50                  55                  60                
 Pro Val Pro Gly Asn Pro Thr Pro Pro Met Thr Pro Gly Ser Ser Ile
  65                  70                  75                  80
 Pro Pro Tyr Leu Ser Pro Ser Gln Asp Val Lys Pro Pro Phe Pro Pro
                  85                  90                  95    
 Asp Ile Lys Pro Asn Met Ser Ala Leu Pro Pro Pro Pro Ala Asn His
             100                 105                 110        
 Asn Asp Glu Pro Ala Ala His Ile Pro Cys Ala Gly Trp Arg Gly Ala
         115                 120                 125            
 Gly Ala Leu Pro Pro Gly Ala Gln Pro Gly Gly Gln Gln Pro Cys Val
     130                 135                 140                
 Pro Pro Ala Ala His Gly Pro Pro Asp Ala Asp Val Glu Val Xaa Pro
 145                 150                 155                 160
 Gly Ala Ala Val Gln Val Leu Pro Pro Arg Gly Pro Ala Asp Glu His
                 165                 170                 175    
 Gln Pro Gly Pro Pro Arg Cys Arg Ser Ala Xaa Thr Pro Arg Pro Ser
             180                 185                 190        
 Pro Leu Ser Ala Ala Thr Thr Arg Pro Pro His Lys Pro Arg Ala Pro
         195                 200                 205            
 Glu Ala Arg Val Pro Ala Gly Pro Gln His His Pro Asp His Arg His
     210                 215                 220                
 Gly Leu Leu Leu Leu Pro Pro Leu Arg Ala Ala Ala Gly Thr Pro Ala
 225                 230                 235                 240
 Leu Arg Pro Leu Cys Ala Ala Arg Thr Pro Gln Glu Ala Pro Pro Ala
                 245                 250                 255    
 Arg Arg Ala Leu
             260



      <210> 1868
      <211> 378
      <212> PRT
      <213> Homo sapiens


      <400> 1868
 Cys Cys Ser Val Pro Asp Gly Ile Tyr Ser Val Met Ala Ser Glu Leu
   1               5                  10                  15    
 Cys Lys Thr Ile Ser Val Ala Arg Leu Glu Lys His Lys Asn Leu Phe
              20                  25                  30        
 Leu Asn Tyr Arg Asn Leu His His Phe Pro Leu Glu Leu Leu Lys Asp
          35                  40                  45            
 Glu Gly Leu Gln Tyr Leu Glu Arg Leu Tyr Met Lys Arg Asn Ser Leu
      50                  55                  60                
 Thr Ser Leu Pro Glu Asn Leu Ala Gln Lys Leu Pro Asn Leu Val Glu
  65                  70                  75                  80
 Leu Tyr Leu His Ser Asn Asn Ile Val Val Val Pro Glu Ala Ile Gly
                  85                  90                  95    
 Ser Leu Val Lys Leu Gln Cys Leu Asp Leu Ser Asp Asn Ala Leu Glu
             100                 105                 110        
 Ile Val Cys Pro Glu Ile Gly Arg Leu Arg Ala Leu Arg His Leu Arg
         115                 120                 125            
 Leu Ala Asn Asn Gln Leu Gln Phe Leu Pro Pro Glu Val Gly Asp Leu
     130                 135                 140                
 Lys Glu Leu Gln Thr Leu Asp Ile Ser Thr Asn Arg Leu Leu Thr Leu
 145                 150                 155                 160
 Pro Glu Arg Leu His Met Cys Leu Ser Leu Gln Tyr Leu Thr Val Asp
                 165                 170                 175    
 Arg Asn Arg Leu Trp Tyr Val Pro Arg His Leu Cys Gln Leu Pro Ser
             180                 185                 190        
 Leu Asn Glu Leu Ser Met Ala Gly Asn Arg Leu Ala Phe Leu Pro Leu
         195                 200                 205            
 Asp Leu Gly Arg Ser Arg Glu Leu Gln Tyr Val Tyr Val Asp Asn Asn
     210                 215                 220                
 Ile His Leu Lys Gly Leu Pro Ser Tyr Leu Tyr Asn Lys Val Ile Gly
 225                 230                 235                 240
 Cys Ser Gly Cys Gly Ala Pro Ile Gln Val Ser Glu Val Lys Leu Leu
                 245                 250                 255    
 Ser Phe Ser Ser Gly Gln Arg Thr Val Phe Leu Pro Ala Glu Val Lys
             260                 265                 270        
 Ala Ile Gly Thr Glu His Asp His Val Leu Pro Leu Gln Glu Leu Ala
         275                 280                 285            
 Met Arg Gly Leu Tyr His Thr Tyr His Ser Leu Leu Lys Asp Leu Asn
     290                 295                 300                
 Phe Leu Ser Pro Ile Ser Leu Pro Arg Ser Leu Leu Glu Leu Leu His
 305                 310                 315                 320
 Cys Pro Leu Gly His Cys His Arg Cys Ser Glu Pro Met Phe Thr Ile
                 325                 330                 335    
 Val Tyr Pro Lys Leu Phe Pro Leu Arg Glu Thr Pro Met Ala Gly Leu
             340                 345                 350        
 His Gln Trp Lys Thr Thr Val Ser Phe Val Ala Tyr Cys Cys Ser Thr
         355                 360                 365            
 Gln Cys Leu Gln Thr Phe Asp Leu Leu Ser
     370                 375            



      <210> 1869
      <211> 125
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(125)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1869
 Gln Gly Ile Ala Leu Leu Thr Arg Met Gly Glu Ser Val Lys His Val
   1               5                  10                  15    
 Thr Gly Gly Tyr Lys Leu Arg Thr Arg Pro Leu Glu Phe Ala Ala Ile
              20                  25                  30        
 Gly Asp Tyr Leu Asp Thr Phe Ala Leu Lys Leu Gly Thr Ile Asp Arg
          35                  40                  45            
 Ile Ala Gln Arg Ile Ile Lys Glu Glu Ile Glu Tyr Leu Val Glu Leu
      50                  55                  60                
 Arg Glu Tyr Gly Pro Val Tyr Ser Thr Trp Ser Ala Leu Glu Gly Glu
  65                  70                  75                  80
 Leu Ala Glu Pro Leu Glu Gly Val Ser Ala Cys Ile Gly Asn Cys Ser
                  85                  90                  95    
 Thr Ala Leu Xaa Glu Leu Thr Asp Asp Met Thr Glu Asp Phe Leu Phe
             100                 105                 110        
 Val Leu Arg Glu Tyr Ile Leu Tyr Ser Asp Ser Met Lys
         115                 120                 125



      <210> 1870
      <211> 434
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(434)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1870
 Gly Arg Val Ala Arg Ala Arg Ser Val Pro Cys Cys Gly Arg Trp Pro
   1               5                  10                  15    
 Leu Ala Arg Leu Arg Arg Leu Ser Trp Arg Ser Lys Met Ala Ala Thr
              20                  25                  30        
 Ala Ala Ala Val Val Ala Glu Glu Asp Thr Glu Leu Arg Asp Leu Leu
          35                  40                  45            
 Val Gln Thr Leu Glu Asn Ser Gly Val Leu Asn Arg Ile Lys Ala Glu
      50                  55                  60                
 Leu Arg Ala Ala Val Phe Leu Ala Leu Glu Glu Gln Glu Lys Val Glu
  65                  70                  75                  80
 Asn Lys Thr Pro Leu Val Asn Glu Ser Leu Lys Lys Phe Leu Asn Thr
                  85                  90                  95    
 Lys Asp Gly Arg Leu Val Ala Ser Leu Val Ala Glu Phe Leu Gln Phe
             100                 105                 110        
 Phe Asn Leu Asp Phe Thr Leu Ala Val Phe Gln Pro Glu Thr Ser Thr
         115                 120                 125            
 Ile Phe Xaa Leu Leu Phe Xaa Leu Gln Gly Leu Glu Gly Arg Glu Asn
     130                 135                 140                
 Leu Ala Arg Asp Leu Gly Ile Ile Glu Ala Glu Gly Thr Val Gly Gly
 145                 150                 155                 160
 Pro Leu Leu Leu Glu Val Ile Arg Arg Cys Gln Gln Lys Glu Lys Gly
                 165                 170                 175    
 Pro Thr Thr Gly Glu Gly Ala Leu Asp Leu Ser Asp Val His Ser Pro
             180                 185                 190        
 Pro Lys Ser Pro Glu Gly Lys Thr Ser Ala Gln Thr Thr Pro Ser Lys
         195                 200                 205            
 Ile Pro Arg Tyr Lys Gly Gln Gly Lys Lys Lys Thr Ser Gly Gln Lys
     210                 215                 220                
 Ala Gly Asp Lys Lys Ala Asn Asp Glu Ala Asn Gln Ser Asp Thr Ser
 225                 230                 235                 240
 Val Ser Leu Ser Glu Pro Lys Ser Lys Ser Ser Leu His Leu Leu Ser
                 245                 250                 255    
 His Glu Thr Lys Ile Val Ser Phe Leu Ser Asn Arg Thr Leu Asp Gly
             260                 265                 270        
 Lys Asp Lys Ala Gly Leu Cys Pro Asp Glu Asp Asp Met Glu Gly Asp
         275                 280                 285            
 Ser Phe Phe Asp Asp Pro Ile Pro Lys Pro Glu Lys Thr Tyr Gly Leu
     290                 295                 300                
 Arg Lys Glu Pro Arg Lys Gln Ala Gly Ser Leu Ala Ser Leu Ser Asp
 305                 310                 315                 320
 Ala Pro Pro Leu Lys Ser Gly Leu Ser Ser Leu Ala Gly Ala Pro Ser
                 325                 330                 335    
 Leu Lys Asp Ser Glu Ser Lys Arg Gly Asn Thr Val Leu Lys Asp Leu
             340                 345                 350        
 Lys Leu Ile Ser Asp Lys Ile Gly Ser Leu Gly Leu Gly Thr Gly Glu
         355                 360                 365            
 Asp Asp Asp Tyr Val Asp Asp Phe Asn Ser Thr Ser His Arg Ser Glu
     370                 375                 380                
 Lys Ser Glu Ile Ser Ile Gly Glu Glu Ile Glu Glu Asp Leu Ser Val
 385                 390                 395                 400
 Glu Ile Asp Asp Ile Asn Thr Ser Asp Lys Leu Asp Asp Leu Thr Gln
                 405                 410                 415    
 Asp Leu Thr Val Ser Gln Leu Ser Asp Val Ala Asp Tyr Leu Glu Asp
             420                 425                 430        
 Val Ala
        



      <210> 1871
      <211> 434
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(434)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1871
 Gly Arg Val Ala Arg Ala Arg Ser Val Pro Cys Cys Gly Arg Trp Pro
   1               5                  10                  15    
 Leu Ala Arg Leu Arg Arg Leu Ser Trp Arg Ser Lys Met Ala Ala Thr
              20                  25                  30        
 Ala Ala Ala Val Val Ala Glu Glu Asp Thr Glu Leu Arg Asp Leu Leu
          35                  40                  45            
 Val Gln Thr Leu Glu Asn Ser Gly Val Leu Asn Arg Ile Lys Ala Glu
      50                  55                  60                
 Leu Arg Ala Ala Val Phe Leu Ala Leu Glu Glu Gln Glu Lys Val Glu
  65                  70                  75                  80
 Asn Lys Thr Pro Leu Val Asn Glu Ser Leu Lys Lys Phe Leu Asn Thr
                  85                  90                  95    
 Lys Asp Gly Arg Leu Val Ala Ser Leu Val Ala Glu Phe Leu Gln Phe
             100                 105                 110        
 Phe Asn Leu Asp Phe Thr Leu Ala Val Phe Gln Pro Glu Thr Ser Thr
         115                 120                 125            
 Ile Phe Xaa Leu Leu Phe Xaa Leu Gln Gly Leu Glu Gly Arg Glu Asn
     130                 135                 140                
 Leu Ala Arg Asp Leu Gly Ile Ile Glu Ala Glu Gly Thr Val Gly Gly
 145                 150                 155                 160
 Pro Leu Leu Leu Glu Val Ile Arg Arg Cys Gln Gln Lys Glu Lys Gly
                 165                 170                 175    
 Pro Thr Thr Gly Glu Gly Ala Leu Asp Leu Ser Asp Val His Ser Pro
             180                 185                 190        
 Pro Lys Ser Pro Glu Gly Lys Thr Ser Ala Gln Thr Thr Pro Ser Lys
         195                 200                 205            
 Ile Pro Arg Tyr Lys Gly Gln Gly Lys Lys Lys Thr Ser Gly Gln Lys
     210                 215                 220                
 Ala Gly Asp Lys Lys Ala Asn Asp Glu Ala Asn Gln Ser Asp Thr Ser
 225                 230                 235                 240
 Val Ser Leu Ser Glu Pro Lys Ser Lys Ser Ser Leu His Leu Leu Ser
                 245                 250                 255    
 His Glu Thr Lys Ile Val Ser Phe Leu Ser Asn Arg Thr Leu Asp Gly
             260                 265                 270        
 Lys Asp Lys Ala Gly Leu Cys Pro Asp Glu Asp Asp Met Glu Gly Asp
         275                 280                 285            
 Ser Phe Phe Asp Asp Pro Ile Pro Lys Pro Glu Lys Thr Tyr Gly Leu
     290                 295                 300                
 Arg Lys Glu Pro Arg Lys Gln Ala Gly Ser Leu Ala Ser Leu Ser Asp
 305                 310                 315                 320
 Ala Pro Pro Leu Lys Ser Gly Leu Ser Ser Leu Ala Gly Ala Pro Ser
                 325                 330                 335    
 Leu Lys Asp Ser Glu Ser Lys Arg Gly Asn Thr Val Leu Lys Asp Leu
             340                 345                 350        
 Lys Leu Ile Ser Asp Lys Ile Gly Ser Leu Gly Leu Gly Thr Gly Glu
         355                 360                 365            
 Asp Asp Asp Tyr Val Asp Asp Phe Asn Ser Thr Ser His Arg Ser Glu
     370                 375                 380                
 Lys Ser Glu Ile Ser Ile Gly Glu Glu Ile Glu Glu Asp Leu Ser Val
 385                 390                 395                 400
 Glu Ile Asp Asp Ile Asn Thr Ser Asp Lys Leu Asp Asp Leu Thr Gln
                 405                 410                 415    
 Asp Leu Thr Val Ser Gln Leu Ser Asp Val Ala Asp Tyr Leu Glu Asp
             420                 425                 430        
 Val Ala
        



      <210> 1872
      <211> 364
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(364)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1872
 Met Arg Gln Lys Arg Lys Glu Glu Lys Glu Leu Phe His Asn Lys Asp
   1               5                  10                  15    
 Cys Glu Lys Lys Glu Lys Asn Ser Trp Glu Arg Met Arg His Thr Gly
              20                  25                  30        
 Thr Glu Lys Met Ala Ser Glu Ser Glu Thr Pro Thr Gly Ala Ile Ser
          35                  40                  45            
 Gln Tyr Lys Glu Arg Met Pro Ser Val Thr His Ser Pro Glu Ile Met
      50                  55                  60                
 Asp Leu Ser Glu Leu Arg Pro Phe Ser Lys Pro Glu Ile Ala Leu Thr
  65                  70                  75                  80
 Glu Ala Leu Arg Leu Leu Ala Asp Glu Asp Trp Asp Lys Gln Leu His
                  85                  90                  95    
 Ala Leu Glu Gln Leu Leu Ala Ser Cys Tyr Ser Gly Thr Arg His Thr
             100                 105                 110        
 Thr Ser Ser Phe His Cys Gly His Gln Gly Met Trp Trp His Pro Glu
         115                 120                 125            
 Ala Trp Arg Cys Leu Ala Thr Ala Glu Pro Gln Arg Glu Pro Gly Lys
     130                 135                 140                
 Ser Thr Ile Ser Ser His Ser Ser Leu Trp Asn Xaa Gln Leu His Ser
 145                 150                 155                 160
 His Lys Leu Gln Ser Val Pro Gly Leu Lys Val Lys Asn Leu Arg Ser
                 165                 170                 175    
 Gly Val Ser Arg Ala Ala Val Val Cys Leu Ser Asp Leu Phe Thr Tyr
             180                 185                 190        
 Leu Lys Lys Ser Met Asp Gln Glu Leu Asp Thr Thr Val Lys Val Leu
         195                 200                 205            
 Leu His Lys Ala Gly Glu Ser Asn Thr Phe Ile Arg Glu Asp Val Asp
     210                 215                 220                
 Lys Ala Leu Arg Ala Met Val Asn Asn Val Thr Pro Ala Arg Ala Val
 225                 230                 235                 240
 Val Ser Leu Ile Asn Gly Gly Gln Ser His Leu His Ile Ala Val Arg
                 245                 250                 255    
 Arg Cys Thr Ala Gln His Leu Ser Asp Val Leu Glu Phe Met Glu Pro
             260                 265                 270        
 Glu Arg Ile Leu Ser Ala Ala Lys Asp Met Ala Glu Arg Ile Leu Pro
         275                 280                 285            
 Ala Ala Ala Lys Phe Ala Gln Asp Ser Ser Gln Glu Thr Arg Tyr Tyr
     290                 295                 300                
 Gly Arg Lys Met Leu Phe Phe Met Met Cys His Pro Asn Phe Glu Lys
 305                 310                 315                 320
 Met Leu Glu Lys Tyr Val Pro Ser Lys Asp Leu Pro Tyr Ile Lys Asp
                 325                 330                 335    
 Ser Val Arg Asn Leu Gln Gln Lys Val Cys Gly Lys Ser Leu Phe Tyr
             340                 345                 350        
 Lys Gln Leu Tyr Lys Gln Ser Leu Phe Leu His Pro
         355                 360                



      <210> 1873
      <211> 467
      <212> PRT
      <213> Homo sapiens


      <400> 1873
 Trp Pro Gly Ala Ala Pro Cys Ala Leu Arg Pro Gly Pro Arg Arg Phe
   1               5                  10                  15    
 Cys Phe Pro Ala Ser Arg Gly Ser Gly Gly Arg Gly Gly Ala Arg Ala
              20                  25                  30        
 Gly Arg Pro Arg Gly Lys Pro Arg Arg Leu Arg Leu Pro Gly Ala Leu
          35                  40                  45            
 Thr Ala Ala Val Met Arg Ile Pro Val Asp Pro Ser Thr Ser Arg Arg
      50                  55                  60                
 Phe Thr Pro Pro Ser Pro Ala Phe Pro Cys Gly Gly Gly Gly Gly Lys
  65                  70                  75                  80
 Met Gly Glu Asn Ser Gly Ala Leu Ser Ala Gln Ala Ala Val Gly Pro
                  85                  90                  95    
 Gly Gly Arg Ala Arg Pro Glu Val Arg Ser Met Val Asp Val Leu Ala
             100                 105                 110        
 Asp His Ala Gly Glu Leu Val Arg Thr Asp Ser Pro Asn Phe Leu Cys
         115                 120                 125            
 Ser Val Val Pro Ser Asp Trp Gly Cys Asn Lys Thr Leu Pro Val Ala
     130                 135                 140                
 Phe Lys Val Val Ala Leu Gly Asp Val Pro Asp Gly Thr Val Val Thr
 145                 150                 155                 160
 Val Met Ala Gly Asn Asp Glu Asn Tyr Ser Val Glu Leu Arg Ile Ala
                 165                 170                 175    
 Ser Ala Val Met Lys Asn Gln Val Ala Arg Phe Asn Asp Leu Arg Phe
             180                 185                 190        
 Val Gly Arg Ser Gly Arg Gly Lys Ser Phe Thr Leu Thr Ile Thr Val
         195                 200                 205            
 Phe Thr Asn Pro Thr Gln Val Ala Thr Tyr His Arg Ala Ile Lys Val
     210                 215                 220                
 Thr Val Asp Gly Pro Arg Glu Pro Arg Arg His Arg Gln Lys Leu Glu
 225                 230                 235                 240
 Asp Gln Thr Lys Pro Phe Pro Asp Arg Phe Gly Asp Leu Glu Arg Leu
                 245                 250                 255    
 Arg Met Arg Val Thr Pro Ser Thr Pro Ser Pro Arg Gly Ser Leu Ser
             260                 265                 270        
 Thr Thr Ser His Phe Ser Ser Gln Pro Gln Thr Pro Ile Gln Gly Thr
         275                 280                 285            
 Ser Glu Leu Asn Pro Phe Ser Asp Pro Arg Gln Phe Asp Arg Ser Phe
     290                 295                 300                
 Pro Thr Leu Pro Thr Leu Thr Glu Ser Arg Phe Pro Asp Pro Arg Met
 305                 310                 315                 320
 His Tyr Pro Gly Ala Met Ser Ala Ala Phe Pro Tyr Ser Ala Thr Pro
                 325                 330                 335    
 Ser Gly Thr Ser Ile Ser Ser Leu Ser Val Ala Gly Met Pro Ala Thr
             340                 345                 350        
 Ser Arg Phe His His Thr Tyr Leu Pro Pro Pro Tyr Pro Gly Ala Pro
         355                 360                 365            
 Gln Asn Gln Ser Gly Pro Phe Gln Ala Asn Pro Ser Pro Tyr His Leu
     370                 375                 380                
 Tyr Tyr Gly Thr Ser Ser Gly Ser Tyr Gln Phe Ser Met Val Ala Gly
 385                 390                 395                 400
 Ser Ser Ser Gly Gly Asp Arg Ser Pro Thr Arg Met Leu Ala Ser Cys
                 405                 410                 415    
 Thr Ser Ser Ala Ala Ser Val Ala Ala Gly Asn Leu Met Asn Pro Ser
             420                 425                 430        
 Leu Gly Gly Gln Ser Asp Gly Val Glu Ala Asp Gly Ser His Ser Asn
         435                 440                 445            
 Ser Pro Thr Ala Leu Ser Thr Pro Gly Arg Met Asp Glu Ala Val Trp
     450                 455                 460                
 Arg Pro Tyr
 465        



      <210> 1874
      <211> 124
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(124)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1874
 Gly Arg Gly Val Cys Val Ala Ala Trp Ser Gln Arg Ser Ile Ala Gly
   1               5                  10                  15    
 Asn Asn Asp Tyr Arg Leu Phe His Lys Met Ser Asn Ser His Pro Leu
              20                  25                  30        
 Arg Pro Phe Thr Ala Val Gly Glu Ile Asp His Val His Ile Leu Ser
          35                  40                  45            
 Glu His Ile Cys Ala Leu Leu Ile Gly Glu Glu Tyr Gly Asp Val Thr
      50                  55                  60                
 Phe Val Gly Glu Lys Lys Arg Phe Pro Ala His Arg Val Ile Leu Ala
  65                  70                  75                  80
 Ala Arg Cys Gln Tyr Phe Arg Ala Leu Leu Tyr Gly Gly Met Arg Glu
                  85                  90                  95    
 Ser Gln Pro Glu Ala Glu Ile Pro Leu Gln Asp Thr Thr Ala Glu Ala
             100                 105                 110        
 Phe Thr Met Leu Leu Xaa Tyr Ile Tyr Thr Gly Arg
         115                 120                



      <210> 1875
      <211> 175
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(175)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1875
 Gly Ala Pro Lys Pro Val Gln His Pro Leu Leu Pro Val Pro Thr Pro
   1               5                  10                  15    
 His Pro Thr Val His Ser Phe Ile Ser Asn His Gly Ile Phe Ser Leu
              20                  25                  30        
 Leu Ser Ser Ser Ala Ala Thr Ala Leu Leu Ile Gln Arg Thr Asn Glu
          35                  40                  45            
 Glu Glu Lys Trp Leu Ala Arg Gln Arg Arg Leu Arg Gln Glu Lys Glu
      50                  55                  60                
 Asp Arg Gln Ser Gln Val Ser Glu Phe Arg Gln Gln Val Leu Glu Gln
  65                  70                  75                  80
 His Leu Asp Met Gly Arg Pro Pro Val Pro Ala Glu Ala Glu His Arg
                  85                  90                  95    
 Pro Glu Ser Thr Thr Arg Xaa Val Ser Pro Arg Lys Glu Gly Gly Met
             100                 105                 110        
 Ser Leu His Val Pro Ile Cys Ser Ala Cys Ile Glu His Leu Leu Phe
         115                 120                 125            
 Ala Arg His Pro Ala Pro Ala Phe Leu Pro Ala Ser Phe Ile Ser Val
     130                 135                 140                
 Leu Ser Ser Ser Arg Tyr Asn Ala Cys Leu Ala Tyr Gly Glu Ala Glu
 145                 150                 155                 160
 Thr Glu Glu Glu Asn Gly Leu Leu Lys Gly Ile Pro Thr Ser Lys
                 165                 170                 175



      <210> 1876
      <211> 51
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(51)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1876
 Ser Leu Asn Gly Ile Glu Trp Asn His Ile Lys Trp Asn Gln Met Glu
   1               5                  10                  15    
 Ser Leu Lys Gly Ile Glu Trp Asn Leu His Arg Met Asn Xaa Met Gln
              20                  25                  30        
 Ser Ser Asn Gly Leu Glu Trp Asn Arg Leu Gln Met Glu Trp Asn Gly
          35                  40                  45            
 Ile Ile Ala
      50    



      <210> 1877
      <211> 160
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(160)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1877
 Arg Leu Tyr Cys Ser Leu Arg Leu Pro Gly Phe Lys Arg Phe Ser Cys
   1               5                  10                  15    
 Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg Arg Val Cys His Ala Gly
              20                  25                  30        
 Xaa Phe Phe Val Phe Leu Val Glu Met Gly Phe His His Val Thr Gln
          35                  40                  45            
 Asp Gly Leu Asn Ile Leu Ser Ser Ser Ile Pro Pro Thr Leu Ala Phe
      50                  55                  60                
 Pro Lys Cys Trp Asp Tyr Arg Arg Asp Asp His Thr Gln Pro Val Phe
  65                  70                  75                  80
 Leu Phe Ser Glu Phe Arg Ile Asp Phe Ser Gly Lys Thr Gly Asp Glu
                  85                  90                  95    
 Asn Leu Pro Ser Ala Leu Leu Ser Ser His Arg Leu Leu Asn Phe Ser
             100                 105                 110        
 Phe Gly His Gln Gly Val Pro Cys Ser Phe Pro Leu Leu Leu Ala His
         115                 120                 125            
 Phe Asp Phe Thr Thr His Asn Arg Gly Gln His Leu Xaa Leu Phe Asn
     130                 135                 140                
 Phe Xaa Ser Ala Leu Leu Ser Leu Gly Val Cys Met Glu Ile Lys His
 145                 150                 155                 160



      <210> 1878
      <211> 51
      <212> PRT
      <213> Homo sapiens


      <400> 1878
 His Glu Arg Ala Gly Gly Leu Gly Ile Asn Leu Thr Ala Ala Asp Thr
   1               5                  10                  15    
 Cys Ile Ile Phe Asp Ser Asp Trp Asn Pro Gln Asn Asp Leu Gln Val
              20                  25                  30        
 Lys Glu Phe Ile Val Leu Gly Thr Asn Tyr Leu Thr Trp Glu Ile Phe
          35                  40                  45            
 Gln Gln Glu
      50    



      <210> 1879
      <211> 159
      <212> PRT
      <213> Homo sapiens


      <400> 1879
 Glu Lys Val Ala Val Leu Cys Lys Glu Asn Tyr Leu Leu Pro Glu Ala
   1               5                  10                  15    
 Lys Glu Ile Val Cys Lys Asp Gly Arg Trp Gln Ser Leu Pro Arg Cys
              20                  25                  30        
 Val Glu Ser Thr Ala Tyr Cys Gly Pro Pro Pro Ser Ile Asn Asn Gly
          35                  40                  45            
 Asp Thr Thr Ser Phe Pro Leu Ser Val Tyr Pro Pro Gly Ser Thr Val
      50                  55                  60                
 Thr Tyr Arg Cys Gln Ser Phe Tyr Lys Leu Gln Gly Ser Val Thr Val
  65                  70                  75                  80
 Thr Cys Arg Asn Lys Gln Trp Ser Glu Pro Pro Arg Cys Leu Asp Pro
                  85                  90                  95    
 Cys Val Val Ser Glu Glu Asn Met Asn Lys Asn Asn Ile Gln Leu Lys
             100                 105                 110        
 Trp Arg Asn Asp Gly Lys Leu Tyr Ala Lys Thr Gly Asp Ala Val Glu
         115                 120                 125            
 Phe Gln Cys Lys Phe Pro His Lys Ala Met Ile Ser Ser Pro Pro Phe
     130                 135                 140                
 Arg Ala Ile Cys Gln Glu Gly Lys Phe Glu Tyr Pro Ile Cys Glu
 145                 150                 155                



      <210> 1880
      <211> 78
      <212> PRT
      <213> Homo sapiens


      <400> 1880
 Met Lys Ser Leu Ala Glu Gln Met Arg Asn His Asp Arg Glu Gln Met
   1               5                  10                  15    
 Ser Arg Met Ala His Asn Leu Pro Glu Gln Tyr Gln Glu Cys Ala Pro
              20                  25                  30        
 Val Glu Gln Val Ala Gln Val Phe Asn Lys Leu Phe Asn Glu Leu Arg
          35                  40                  45            
 Ala Ala Phe Pro Ala Ser Met Ala Asn Phe Arg Thr Gln Glu Asp Leu
      50                  55                  60                
 Asn Glu Phe His Arg Gln Trp Leu Leu Ala Phe Gln Glu Asn
  65                  70                  75            



      <210> 1881
      <211> 245
      <212> PRT
      <213> Homo sapiens


      <400> 1881
 Leu Pro Gly Ser Gly Lys Arg Ser Ser Cys Cys His Cys Ser Ser Gly
   1               5                  10                  15    
 Ala Cys Ser Met Gly Pro Leu Pro Arg Thr Val Glu Leu Phe Tyr Asp
              20                  25                  30        
 Val Leu Ser Pro Tyr Ser Trp Leu Gly Phe Glu Ile Leu Cys Arg Tyr
          35                  40                  45            
 Gln Asn Ile Trp Asn Ile Asn Leu Gln Leu Arg Pro Ser Leu Ile Thr
      50                  55                  60                
 Gly Ile Met Lys Asp Ser Gly Asn Lys Pro Pro Gly Leu Leu Pro Arg
  65                  70                  75                  80
 Lys Gly Leu Tyr Met Ala Asn Asp Leu Lys Leu Leu Arg His His Leu
                  85                  90                  95    
 Gln Ile Pro Ile His Phe Pro Lys Asp Phe Leu Ser Val Met Leu Glu
             100                 105                 110        
 Lys Gly Ser Leu Ser Ala Met Arg Phe Leu Thr Ala Val Asn Leu Glu
         115                 120                 125            
 His Pro Glu Met Leu Glu Lys Ala Ser Arg Glu Leu Trp Met Arg Val
     130                 135                 140                
 Trp Ser Arg Asn Glu Asp Ile Thr Glu Pro Gln Ser Ile Leu Ala Ala
 145                 150                 155                 160
 Ala Glu Lys Ala Gly Met Ser Ala Glu Gln Ala Gln Gly Leu Leu Glu
                 165                 170                 175    
 Lys Ile Ala Thr Pro Lys Val Lys Asn Gln Leu Lys Glu Thr Thr Glu
             180                 185                 190        
 Ala Ala Cys Arg Tyr Gly Ala Phe Gly Leu Pro Ile Thr Val Ala His
         195                 200                 205            
 Val Asp Gly Gln Thr His Met Leu Phe Gly Ser Asp Arg Met Glu Leu
     210                 215                 220                
 Leu Ala His Leu Leu Gly Glu Lys Trp Met Gly Pro Ile Pro Pro Ala
 225                 230                 235                 240
 Val Asn Ala Arg Leu
                 245



      <210> 1882
      <211> 245
      <212> PRT
      <213> Homo sapiens


      <400> 1882
 Leu Pro Gly Ser Gly Lys Arg Ser Ser Cys Cys His Cys Ser Ser Gly
   1               5                  10                  15    
 Ala Cys Ser Met Gly Pro Leu Pro Arg Thr Val Glu Leu Phe Tyr Asp
              20                  25                  30        
 Val Leu Ser Pro Tyr Ser Trp Leu Gly Phe Glu Ile Leu Cys Arg Tyr
          35                  40                  45            
 Gln Asn Ile Trp Asn Ile Asn Leu Gln Leu Arg Pro Ser Leu Ile Thr
      50                  55                  60                
 Gly Ile Met Lys Asp Ser Gly Asn Lys Pro Pro Gly Leu Leu Pro Arg
  65                  70                  75                  80
 Lys Gly Leu Tyr Met Ala Asn Asp Leu Lys Leu Leu Arg His His Leu
                  85                  90                  95    
 Gln Ile Pro Ile His Phe Pro Lys Asp Phe Leu Ser Val Met Leu Glu
             100                 105                 110        
 Lys Gly Ser Leu Ser Ala Met Arg Phe Leu Thr Ala Val Asn Leu Glu
         115                 120                 125            
 His Pro Glu Met Leu Glu Lys Ala Ser Arg Glu Leu Trp Met Arg Val
     130                 135                 140                
 Trp Ser Arg Asn Glu Asp Ile Thr Glu Pro Gln Ser Ile Leu Ala Ala
 145                 150                 155                 160
 Ala Glu Lys Ala Gly Met Ser Ala Glu Gln Ala Gln Gly Leu Leu Glu
                 165                 170                 175    
 Lys Ile Ala Thr Pro Lys Val Lys Asn Gln Leu Lys Glu Thr Thr Glu
             180                 185                 190        
 Ala Ala Cys Arg Tyr Gly Ala Phe Gly Leu Pro Ile Thr Val Ala His
         195                 200                 205            
 Val Asp Gly Gln Thr His Met Leu Phe Gly Ser Asp Arg Met Glu Leu
     210                 215                 220                
 Leu Ala His Leu Leu Gly Glu Lys Trp Met Gly Pro Ile Pro Pro Ala
 225                 230                 235                 240
 Val Asn Ala Arg Leu
                 245



      <210> 1883
      <211> 535
      <212> PRT
      <213> Homo sapiens


      <400> 1883
 Pro Ala His Asp Asp Phe Tyr Leu Val Val Cys Ser Ala Cys Asn Gln
   1               5                  10                  15    
 Val Val Lys Pro Gln Val Phe Gln Ser His Cys Glu Arg Arg His Gly
              20                  25                  30        
 Ser Met Cys Arg Pro Ser Pro Ser Pro Val Phe Ser Ser Leu Gln Ser
          35                  40                  45            
 Gln Asp Ile Thr Ser Thr Gly Glu Asn Lys Ser Leu Ser Ser Gly His
      50                  55                  60                
 His Ser Ala Ser Ser Thr Ser Lys Pro Phe Lys Thr Pro Lys Asp Asn
  65                  70                  75                  80
 Leu Leu Thr Ser Ser Ser Lys Gln His Thr Val Phe Pro Ala Lys Gly
                  85                  90                  95    
 Ser Arg Asp Lys Pro Cys Val Pro Val Pro Val Val Ser Leu Glu Lys
             100                 105                 110        
 Ile Pro Asn Leu Val Lys Ala Asp Gly Ala Asn Val Lys Met Asn Ser
         115                 120                 125            
 Thr Thr Thr Thr Ala Val Ser Ala Ser Ser Thr Ser Ser Ser Ala Val
     130                 135                 140                
 Ser Thr Pro Pro Leu Ile Lys Pro Val Leu Met Ser Lys Ser Val Pro
 145                 150                 155                 160
 Pro Ser Pro Glu Lys Ile Leu Asn Gly Lys Gly Ile Leu Pro Thr Thr
                 165                 170                 175    
 Ile Asp Lys Arg Arg Gln Asn Gly Thr Asn Ser Ser Asn Lys Pro Tyr
             180                 185                 190        
 Arg Arg Leu Ser Glu Arg Glu Phe Asp Pro Asn Lys His Cys Gly Val
         195                 200                 205            
 Leu Asp Ala Glu Thr Lys Lys Pro Cys Thr Arg Ser Leu Thr Cys Lys
     210                 215                 220                
 Thr His Ser Leu Ser His Arg Arg Ala Val Pro Gly Arg Lys Lys Gln
 225                 230                 235                 240
 Phe Asp Leu Leu Leu Ala Glu His Lys Ala Lys Ser Arg Glu Lys Glu
                 245                 250                 255    
 Val Lys Asp Lys Glu His Leu Leu Thr Ser Thr Arg Glu Ile Leu Pro
             260                 265                 270        
 Ser Gln Ser Gly Pro Ala Gln Asp Ser Leu Leu Gly Ser Ser Gly Ser
         275                 280                 285            
 Ser Gly Pro Glu Pro Lys Val Ala Ser Pro Ala Lys Ser Arg Pro Pro
     290                 295                 300                
 Asn Ser Val Leu Pro Arg Pro Ser Ser Ala Asn Ser Ile Ser Ser Ser
 305                 310                 315                 320
 Thr Ser Ser Asn His Ser Gly His Thr Pro Glu Pro Pro Leu Pro Pro
                 325                 330                 335    
 Val Gly Gly Asp Leu Ala Ser Arg Leu Ser Ser Asp Glu Gly Glu Met
             340                 345                 350        
 Asp Gly Ala Asp Glu Ser Glu Lys Leu Asp Cys Gln Phe Ser Thr His
         355                 360                 365            
 His Pro Arg Pro Met Ala Phe Cys Ser Phe Gly Ser Arg Leu Met Gly
     370                 375                 380                
 Arg Gly Tyr Tyr Val Phe Asp Arg Arg Trp Asp Arg Phe Arg Phe Ala
 385                 390                 395                 400
 Leu Asn Ser Met Val Glu Lys His Leu Asn Ser Gln Met Trp Lys Lys
                 405                 410                 415    
 Ile Pro Pro Ala Thr Asp Ser Pro Leu Pro Ser Pro Ala Ala His Ile
             420                 425                 430        
 Thr Thr Pro Val Pro Ala Ser Val Leu Gln Pro Phe Ser Asn Pro Ser
         435                 440                 445            
 Ala Val Tyr Leu Pro Ser Ala Pro Ile Ser Ser Arg Leu Thr Ser Ser
     450                 455                 460                
 Tyr Ile Met Thr Ser Ala Met Leu Ser Asn Ala Ala Phe Val Thr Ser
 465                 470                 475                 480
 Pro Asp Pro Ser Ala Leu Met Ser His Thr Thr Ala Phe Pro His Val
                 485                 490                 495    
 Ala Ala Thr Leu Ser Ile Met Asp Ser Thr Phe Lys Ala Pro Ser Ala
             500                 505                 510        
 Val Ser Pro Ile Pro Ala Val Ile Pro Ser Pro Ser His Lys Pro Ser
         515                 520                 525            
 Lys Thr Lys Thr Ser Tyr Glu
     530                 535



      <210> 1884
      <211> 138
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(138)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1884
 Val Ala Arg Gly Pro Arg Leu Arg Gly Gly Leu Leu Pro Ala Cys His
   1               5                  10                  15    
 His Arg Pro Gly Thr Ala Ala Ala Glu Cys Gly Glu Ala Ala Ala Asp
              20                  25                  30        
 Gly Ala Gly Pro Gly Gly Pro Glu Ala Gly Gly Ala Ala Ala Gly Ala
          35                  40                  45            
 Pro Pro Ala Gly Ala Xaa Gly Gly Ala Glu Pro Ala Ala Ala Gln Pro
      50                  55                  60                
 Ser Phe Leu Arg Glu Asn Gly Pro Asn Cys Cys Xaa Gly Leu Asn Pro
  65                  70                  75                  80
 Asp Pro Ser Thr Val Met Gly Val His Gly Xaa Gly Gly Gly Gln Ala
                  85                  90                  95    
 Gly Pro Ala Ala Pro Leu Gly Pro Cys Gly Met Pro Gly Arg Pro Gly
             100                 105                 110        
 Trp Pro Asn Gly Gln Thr Gly Pro Gly Ser Pro Pro Pro Gly Ala Ser
         115                 120                 125            
 Gly Trp Thr Phe Gln Val Val Pro Trp Gly
     130                 135            



      <210> 1885
      <211> 62
      <212> PRT
      <213> Homo sapiens


      <400> 1885
 Leu Ser Phe Cys Ser Pro Ser Thr Thr Ala Val Cys Arg Cys Arg Arg
   1               5                  10                  15    
 Pro Ala Ala Asp Cys His Pro Ser Gly Ser Gly Arg Val Ser Thr Val
              20                  25                  30        
 Leu Leu Ile Gln Met Arg His Pro Leu Pro Leu Pro Ile Arg Leu Lys
          35                  40                  45            
 Ala Cys His Cys Ser Cys Thr Ala Arg Cys Pro Gly Leu Ser
      50                  55                  60        



      <210> 1886
      <211> 131
      <212> PRT
      <213> Homo sapiens


      <400> 1886
 Pro Gln Met Leu Thr Pro Gln Gln Met Gln Leu Ile Leu Ser Pro Pro
   1               5                  10                  15    
 Gln Leu Gln Ala Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln
              20                  25                  30        
 Leu Gln Glu Tyr Tyr Lys Lys Gln Gln Glu Gln Leu His Leu Gln Leu
          35                  40                  45            
 Leu Thr Gln Gln Gln Ala Gly Lys Pro Gln Pro Lys Glu Ala Leu Gly
      50                  55                  60                
 Asn Lys Gln Leu Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu
  65                  70                  75                  80
 Gln Gln Gln His Leu Leu Asn Leu Gln Arg Gln Gly Leu Val Ser Leu
                  85                  90                  95    
 Gln Pro Asn Gln Ala Ser Gly Pro Leu Gln Thr Leu Pro Gln Ala Ala
             100                 105                 110        
 Val Cys Pro Thr Asp Leu Pro Gln Leu Gly Lys Gly Glu Gly Ala Pro
         115                 120                 125            
 Gly Gln Pro
     130    



      <210> 1887
      <211> 132
      <212> PRT
      <213> Homo sapiens


      <400> 1887
 Ile Asp Leu Met Ala Asp Glu Ile Gly Leu Trp Ala Val Tyr Ala Thr
   1               5                  10                  15    
 Asn Gln Asn Ala Gly Asn Ile Val Ile Ser Gln Leu Asn Gln Asp Thr
              20                  25                  30        
 Leu Glu Val Met Lys Ser Trp Ser Thr Gly Tyr Pro Lys Arg Ser Ala
          35                  40                  45            
 Gly Glu Ser Phe Met Ile Cys Gly Thr Leu Tyr Val Thr Asn Ser His
      50                  55                  60                
 Leu Thr Gly Ala Lys Val Tyr Tyr Ser Tyr Ser Thr Lys Pro Ser Thr
  65                  70                  75                  80
 Tyr Glu Tyr Thr Asp Ile Pro Phe His Asn Gln Tyr Phe His Ile Ser
                  85                  90                  95    
 Met Leu Asp Tyr Asn Ala Arg Asp Arg Ala Leu Tyr Ala Trp Asn Asn
             100                 105                 110        
 Gly His Gln Val Leu Phe Asn Val Thr Leu Phe His Ile Ile Lys Thr
         115                 120                 125            
 Glu Asp Asp Thr
     130        



      <210> 1888
      <211> 614
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(614)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1888
 Tyr Ser Pro Arg Pro Arg Arg Arg Arg Lys Gly Arg Arg Ala Arg Arg
   1               5                  10                  15    
 Glu Val Gln Glu Gly Pro Ser Pro Trp Val His Gly Pro Arg Val Ala
              20                  25                  30        
 Glu Asp Thr Gly Leu Val Pro Asn Trp Leu Leu Leu Leu Pro Val Ala
          35                  40                  45            
 Ser Met Ala Glu Asp Trp Leu Asp Cys Pro Ala Leu Gly Pro Gly Trp
      50                  55                  60                
 Lys Arg Arg Glu Val Phe Arg Lys Ser Gly Ala Thr Cys Gly Arg Ser
  65                  70                  75                  80
 Asp Thr Tyr Tyr Gln Ser Pro Thr Gly Asp Arg Ile Arg Ser Lys Val
                  85                  90                  95    
 Glu Leu Thr Arg Tyr Leu Gly Pro Ala Cys Asp Leu Thr Leu Phe Asp
             100                 105                 110        
 Phe Lys Gln Gly Ile Leu Cys Tyr Pro Ala Pro Lys Ala His Pro Val
         115                 120                 125            
 Ala Val Ala Ser Lys Lys Arg Lys Lys Pro Ser Arg Pro Ala Lys Thr
     130                 135                 140                
 Arg Lys Arg Gln Val Gly Pro Gln Ser Gly Glu Val Arg Lys Glu Ala
 145                 150                 155                 160
 Pro Arg Asp Glu Thr Lys Ala Asp Thr Asp Thr Ala Pro Ala Ser Phe
                 165                 170                 175    
 Pro Ala Pro Gly Cys Cys Glu Asn Cys Gly Ile Ser Phe Ser Gly Asp
             180                 185                 190        
 Gly Thr Gln Arg Gln Arg Leu Lys Thr Leu Cys Lys Asp Cys Arg Ala
         195                 200                 205            
 Gln Arg Ile Ala Phe Asn Arg Glu Gln Arg Met Phe Lys Ser Arg Gly
     210                 215                 220                
 Cys Gly Val Cys Arg Gly Cys Gln Thr Gln Glu Asp Cys Gly His Cys
 225                 230                 235                 240
 Pro Ile Cys Leu Arg Pro Pro Arg Pro Gly Leu Arg Arg Gln Trp Lys
                 245                 250                 255    
 Cys Val Gln Arg Arg Cys Leu Arg Gly Lys His Ala Arg Arg Lys Gly
             260                 265                 270        
 Gly Cys Asp Ser Lys Met Ala Ala Arg Arg Arg Pro Gly Ala Gln Pro
         275                 280                 285            
 Leu Pro Pro Pro Pro Pro Ser Gln Ser Pro Glu Pro Thr Glu Pro His
     290                 295                 300                
 Pro Arg Ala Leu Ala Pro Ser Pro Pro Ala Glu Phe Ile Tyr Tyr Cys
 305                 310                 315                 320
 Val Asp Glu Asp Glu Leu Gln Pro Tyr Thr Asn Arg Arg Gln Asn Arg
                 325                 330                 335    
 Lys Cys Gly Ala Cys Ala Ala Cys Leu Arg Arg Asn Gly Cys Gly Arg
             340                 345                 350        
 Cys Asp Phe Cys Cys Asp Lys Pro Lys Phe Gly Gly Ser Asn Gln Lys
         355                 360                 365            
 Arg Gln Lys Cys Arg Trp Arg Gln Cys Leu Gln Phe Ala Met Lys Arg
     370                 375                 380                
 Leu Leu Pro Ser Val Trp Ser Glu Ser Glu Asp Gly Ala Gly Ser Pro
 385                 390                 395                 400
 Pro Pro Tyr Arg Arg Arg Lys Arg Pro Ser Ser Ala Arg Arg His His
                 405                 410                 415    
 Leu Gly Pro Thr Leu Lys Pro Thr Leu Ala Thr Arg Thr Ala Gln Pro
             420                 425                 430        
 Asp His Thr Gln Ala Pro Thr Lys Gln Glu Ala Gly Gly Gly Phe Val
         435                 440                 445            
 Leu Pro Pro Pro Gly His Xaa Thr Leu Cys Phe Leu Arg Glu Gly Ala
     450                 455                 460                
 Ser Ser Pro Val Gln Val Pro Gly Pro Val Ala Ala Ser Thr Glu Ala
 465                 470                 475                 480
 Leu Leu Gln Glu Ala Gln Cys Ser Gly Met Ser Trp Val Val Ala Leu
                 485                 490                 495    
 Pro Gln Val Lys Gln Glu Lys Ala Asp Thr Gln Asp Glu Trp Thr Pro
             500                 505                 510        
 Gly Thr Ala Val Leu Thr Ser Pro Val Leu Val Pro Gly Cys Pro Ser
         515                 520                 525            
 Lys Ala Val Asp Pro Gly Leu Pro Ser Val Lys Gln Glu Pro Pro Asp
     530                 535                 540                
 Pro Glu Glu Asp Lys Glu Glu Asn Lys Asp Asp Ser Ala Ser Lys Leu
 545                 550                 555                 560
 Ala Pro Glu Glu Glu Ala Gly Gly Ala Gly Thr Pro Val Ile Thr Glu
                 565                 570                 575    
 Ile Phe Ser Leu Gly Gly Thr Arg Phe Arg Asp Thr Ala Val Trp Leu
             580                 585                 590        
 Pro Arg Ser Lys Asp Leu Lys Lys Pro Gly Ala Arg Lys Gln Leu Thr
         595                 600                 605            
 Gly Gly Phe Tyr Arg Leu
     610                



      <210> 1889
      <211> 95
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(95)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1889
 Glu Cys Val Cys Leu Tyr Ile Tyr Leu His Val Ser Val Gly Leu Xaa
   1               5                  10                  15    
 Met Cys Ile Xaa Thr Tyr Arg Cys Val Tyr Val Gln Val Cys Val Lys
              20                  25                  30        
 Val Cys Ala Cys Val Ser Thr Ser Met Cys Met Cys Leu Cys Lys Cys
          35                  40                  45            
 Ile Cys Met Cys Thr Cys Glu Gly Met Cys Met Cys Ile Cys Val Cys
      50                  55                  60                
 Ile Ser Glu Cys Val Tyr Arg Cys Met His Met Cys Ile Ile Phe Xaa
  65                  70                  75                  80
 Val Ser Cys Leu Cys Ala Pro Ser Tyr Met Cys Phe Ala Pro Cys
                  85                  90                  95



      <210> 1890
      <211> 468
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(468)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1890
 Thr Arg Gln Ala Trp His Glu Gly Pro Arg Gly Val Pro His Ser Ala
   1               5                  10                  15    
 Ser Leu Arg Ser Ala Arg Arg Gln Ser Ala Pro Ser Leu Thr Glu Ser
              20                  25                  30        
 Pro Thr Ser Leu Pro Ser Cys Ile Ser Lys Met Ser Leu Ser Asn Lys
          35                  40                  45            
 Leu Thr Leu Asp Lys Leu Asp Val Lys Gly Lys Arg Val Val Met Arg
      50                  55                  60                
 Val Asp Phe Asn Val Pro Met Lys Asn Asn Gln Ile Thr Asn Asn Gln
  65                  70                  75                  80
 Arg Ile Lys Ala Ala Val Pro Ser Ile Lys Phe Cys Leu Asp Asn Gly
                  85                  90                  95    
 Ala Lys Ser Val Val Leu Met Ser His Leu Gly Arg Pro Asp Gly Val
             100                 105                 110        
 Pro Met Pro Asp Lys Tyr Ser Leu Glu Pro Val Ala Val Glu Leu Lys
         115                 120                 125            
 Ser Leu Leu Gly Lys Asp Val Leu Phe Leu Lys Asp Cys Val Gly Pro
     130                 135                 140                
 Glu Val Glu Lys Ala Cys Ala Asn Pro Ala Ala Gly Ser Val Ile Leu
 145                 150                 155                 160
 Leu Glu Asn Leu Arg Phe His Val Glu Glu Glu Gly Lys Gly Lys Asp
                 165                 170                 175    
 Ala Ser Gly Asn Lys Val Lys Ala Glu Pro Ala Lys Ile Glu Ala Phe
             180                 185                 190        
 Arg Ala Ser Leu Ser Lys Leu Gly Asp Val Tyr Val Asn Asp Ala Phe
         195                 200                 205            
 Gly Thr Ala His Arg Ala His Ser Ser Met Val Gly Val Asn Leu Pro
     210                 215                 220                
 Gln Lys Ala Gly Gly Phe Leu Met Lys Lys Glu Leu Asn Tyr Phe Ala
 225                 230                 235                 240
 Lys Ala Leu Glu Ser Pro Glu Arg Pro Phe Leu Ala Ile Leu Gly Gly
                 245                 250                 255    
 Ala Lys Val Ala Asp Lys Ile Gln Leu Ile Asn Asn Met Leu Asp Lys
             260                 265                 270        
 Val Asn Glu Met Ile Ile Gly Gly Gly Met Ala Phe Thr Phe Leu Lys
         275                 280                 285            
 Val Leu Asn Asn Met Glu Ile Gly Thr Ser Leu Phe Asp Glu Glu Gly
     290                 295                 300                
 Ala Lys Ile Val Lys Asp Leu Met Ser Lys Ala Glu Lys Asn Gly Val
 305                 310                 315                 320
 Lys Ile Thr Leu Pro Val Asp Phe Val Thr Ala Asp Lys Phe Asp Glu
                 325                 330                 335    
 Asn Ala Lys Thr Gly Gln Ala Thr Val Ala Ser Gly Ile Pro Ala Gly
             340                 345                 350        
 Trp Met Gly Leu Asp Cys Gly Pro Glu Ser Ser Lys Lys Tyr Ala Glu
         355                 360                 365            
 Ala Val Thr Arg Ala Lys Gln Ile Val Trp Asn Gly Pro Val Gly Val
     370                 375                 380                
 Phe Glu Trp Glu Ala Phe Ala Arg Gly Thr Lys Ala Leu Met Asp Glu
 385                 390                 395                 400
 Val Gly Glu Ser Thr Ser Thr Ser Arg Gly Leu Ala Ile Thr Ile Ile
                 405                 410                 415    
 Gly Gly Gly Asp Thr Cys Pro Leu Gly Cys Cys Pro Asn Gly Asn Thr
             420                 425                 430        
 Gly Gly Xaa Lys Ser Ser His Val Glu Ser Leu Gly Gly Trp Cys Pro
         435                 440                 445            
 Val Leu Glu Leu Leu Glu Val Xaa Thr Ser Phe Thr Gly Val Asp Ala
     450                 455                 460                
 Leu Ser Asn Ile
 465            



      <210> 1891
      <211> 304
      <212> PRT
      <213> Homo sapiens


      <400> 1891
 Asn Arg Gly Pro Ala Gly Val Pro Ala Ala Ala Ala Met Gln Lys Tyr
   1               5                  10                  15    
 Glu Lys Leu Glu Lys Ile Gly Glu Gly Thr Tyr Gly Thr Val Phe Lys
              20                  25                  30        
 Ala Lys Asn Arg Glu Thr His Glu Ile Val Ala Leu Lys Arg Val Arg
          35                  40                  45            
 Leu Asp Asp Asp Asp Glu Gly Val Pro Ser Ser Ala Leu Arg Glu Ile
      50                  55                  60                
 Cys Leu Leu Lys Glu Leu Lys His Lys Asn Ile Val Arg Leu His Asp
  65                  70                  75                  80
 Val Leu His Ser Asp Lys Lys Leu Thr Leu Val Phe Glu Phe Cys Asp
                  85                  90                  95    
 Gln Asp Leu Lys Lys Tyr Phe Asp Ser Cys Asn Gly Asp Leu Asp Pro
             100                 105                 110        
 Glu Ile Val Lys Ser Phe Leu Phe Gln Leu Leu Lys Gly Leu Gly Phe
         115                 120                 125            
 Cys His Ser Arg Asn Val Leu His Arg Asp Leu Lys Pro Gln Asn Leu
     130                 135                 140                
 Leu Ile Asn Arg Asn Gly Glu Leu Lys Leu Ala Asp Phe Gly Leu Ala
 145                 150                 155                 160
 Arg Ala Phe Gly Ile Pro Val Arg Cys Tyr Ser Ala Glu Val Val Thr
                 165                 170                 175    
 Leu Trp Tyr Arg Pro Pro Asp Val Leu Phe Gly Ala Lys Leu Tyr Ser
             180                 185                 190        
 Thr Ser Ile Asp Met Trp Ser Ala Gly Cys Ile Phe Ala Glu Leu Ala
         195                 200                 205            
 Asn Ala Gly Arg Pro Leu Phe Pro Gly Asn Asp Val Asp Asp Gln Leu
     210                 215                 220                
 Lys Arg Ile Phe Arg Leu Leu Gly Thr Pro Thr Glu Glu Gln Trp Pro
 225                 230                 235                 240
 Ser Met Thr Lys Leu Pro Asp Tyr Lys Pro Tyr Pro Met Tyr Pro Ala
                 245                 250                 255    
 Thr Thr Ser Leu Val Asn Val Val Pro Lys Leu Asn Ala Thr Gly Arg
             260                 265                 270        
 Asp Leu Leu Gln Asn Leu Leu Lys Cys Asn Pro Val Gln Arg Ile Ser
         275                 280                 285            
 Ala Glu Glu Ala Leu Gln His Pro Tyr Phe Ser Asp Phe Cys Pro Pro
     290                 295                 300                



      <210> 1892
      <211> 368
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(368)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1892
 Gly Ala Thr Pro Leu Gly Ser Val Gly Gly Arg Thr Gly Lys Met Asp
   1               5                  10                  15    
 Ala Ala Thr Leu Thr Tyr Asp Thr Leu Arg Phe Ala Glu Phe Glu Asp
              20                  25                  30        
 Phe Pro Glu Thr Ser Glu Pro Val Trp Ile Leu Gly Arg Lys Tyr Ser
          35                  40                  45            
 Ile Phe Thr Glu Lys Asp Glu Ile Leu Ser Asp Val Ala Ser Arg Leu
      50                  55                  60                
 Trp Phe Thr Tyr Arg Lys Asn Phe Pro Ala Ile Gly Gly Thr Gly Pro
  65                  70                  75                  80
 Thr Ser Asp Thr Gly Trp Gly Cys Met Leu Arg Cys Gly Gln Met Ile
                  85                  90                  95    
 Phe Ala Gln Ala Leu Val Cys Arg His Leu Gly Arg Asp Trp Arg Trp
             100                 105                 110        
 Thr Gln Arg Lys Arg Gln Pro Asp Ser Tyr Phe Ser Val Leu Asn Ala
         115                 120                 125            
 Phe Ile Asp Arg Lys Asp Ser Tyr Tyr Ser Ile His Gln Ile Ala Gln
     130                 135                 140                
 Met Gly Val Gly Glu Gly Lys Ser Ile Gly Gln Trp Tyr Gly Pro Asn
 145                 150                 155                 160
 Thr Val Ala Gln Val Leu Lys Lys Leu Ala Val Phe Asp Thr Trp Ser
                 165                 170                 175    
 Ser Leu Ala Val His Ile Ala Met Asp Asn Thr Val Val Met Glu Glu
             180                 185                 190        
 Ile Arg Arg Leu Cys Arg Thr Ser Val Pro Cys Ala Gly Ala Thr Ala
         195                 200                 205            
 Phe Pro Ala Asp Ser Asp Arg His Cys Asn Gly Phe Pro Ala Gly Ala
     210                 215                 220                
 Glu Val Thr Asn Arg Pro Ser Pro Trp Arg Pro Leu Val Leu Leu Ile
 225                 230                 235                 240
 Pro Leu Arg Leu Gly Leu Thr Asp Ile Asn Glu Ala Tyr Val Glu Thr
                 245                 250                 255    
 Leu Lys His Cys Phe Met Met Pro Gln Ser Leu Gly Val Ile Gly Gly
             260                 265                 270        
 Lys Pro Asn Ser Ala His Tyr Phe Ile Gly Xaa Val Gly Glu Glu Leu
         275                 280                 285            
 Ile Tyr Leu Asp Pro His Thr Thr Gln Pro Ala Val Glu Pro Thr Asp
     290                 295                 300                
 Gly Cys Phe Ile Pro Asp Glu Ser Phe His Cys Gln His Pro Pro Cys
 305                 310                 315                 320
 Arg Met Ser Ile Ala Glu Leu Asp Pro Ser Ile Ala Val Val Arg Gly
                 325                 330                 335    
 Gly His Leu Ser Thr Gln Ala Phe Gly Ala Glu Cys Cys Leu Gly Met
             340                 345                 350        
 Thr Arg Lys Thr Phe Gly Phe Leu Arg Phe Phe Phe Ser Met Leu Gly
         355                 360                 365            



      <210> 1893
      <211> 30
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(30)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1893
 Arg Cys Tyr Cys Ser Ile Xaa Pro Cys Phe His Leu Phe Gln Leu Ser
   1               5                  10                  15    
 Phe Gln Ile Leu Asp Pro Pro Val Leu Gly Thr Thr Phe Leu
              20                  25                  30



      <210> 1894
      <211> 93
      <212> PRT
      <213> Homo sapiens


      <400> 1894
 Ile Gln Gly Met His Phe Ala Ala Gly Arg Leu Ser Thr Lys Thr Phe
   1               5                  10                  15    
 Cys Thr Gly His Gly Ser Pro Val Asp Ile Cys Thr Ala Lys Pro Arg
              20                  25                  30        
 Asp Ile Pro Met Asn Pro Met Gly Ile Tyr Arg Ser Pro Glu Lys Lys
          35                  40                  45            
 Ala Thr Glu Asp Glu Gly Ser Glu Gln Lys Ile Pro Glu Ala Thr Asn
      50                  55                  60                
 Arg Arg Asp Val Glu Pro Thr Lys Ala Asn Ser Arg Phe Ala Thr Thr
  65                  70                  75                  80
 Phe Tyr Gln His Leu Ala Asp Ser Lys Asn Asp Asn Asp
                  85                  90            



      <210> 1895
      <211> 368
      <212> PRT
      <213> Homo sapiens


      <400> 1895
 Thr Ala Ala Ala Pro Val Ala Pro Gly Thr Met Asp Asp Ala Thr Val
   1               5                  10                  15    
 Leu Arg Lys Lys Gly Tyr Ile Val Gly Ile Asn Leu Gly Lys Gly Ser
              20                  25                  30        
 Tyr Ala Lys Val Lys Ser Ala Tyr Ser Glu Arg Leu Lys Phe Asn Val
          35                  40                  45            
 Ala Val Lys Ile Ile Ala Arg Lys Lys Thr Pro Thr Asp Phe Val Glu
      50                  55                  60                
 Arg Phe Leu Pro Arg Glu Met Asp Ile Leu Ala Thr Val Asn His Gly
  65                  70                  75                  80
 Ser Ile Ile Lys Thr Tyr Glu Ile Phe Glu Thr Ser Asp Gly Arg Ile
                  85                  90                  95    
 Tyr Ile Ile Met Glu Leu Gly Val Gln Gly Asp Leu Leu Glu Phe Ile
             100                 105                 110        
 Lys Cys Gln Gly Ala Leu His Glu Asp Val Ala Arg Lys Met Phe Arg
         115                 120                 125            
 Gln Leu Ser Ser Ala Val Lys Tyr Cys His Asp Leu Asp Ile Val His
     130                 135                 140                
 Arg Asp Leu Lys Cys Glu Asn Leu Leu Leu Asp Lys Asp Phe Asn Ile
 145                 150                 155                 160
 Lys Leu Ser Asp Phe Gly Phe Ser Lys Arg Cys Leu Arg Asp Ser Asn
                 165                 170                 175    
 Gly Arg Ile Ile Leu Ser Lys Thr Phe Cys Gly Ser Ala Ala Tyr Ala
             180                 185                 190        
 Ala Pro Glu Val Leu Gln Ser Ile Pro Tyr Gln Pro Lys Val Tyr Asp
         195                 200                 205            
 Ile Trp Ser Leu Gly Val Ile Leu Tyr Ile Met Val Cys Gly Ser Met
     210                 215                 220                
 Pro Tyr Asp Asp Ser Asp Ile Arg Lys Met Leu Arg Ile Gln Lys Glu
 225                 230                 235                 240
 His Arg Val Asp Phe Pro Arg Ser Lys Asn Leu Thr Cys Glu Cys Lys
                 245                 250                 255    
 Asp Leu Ile Tyr Arg Met Leu Gln Pro Asp Val Ser Lys Arg Leu His
             260                 265                 270        
 Ile Asp Glu Ile Leu Ser His Ser Trp Leu Gln Pro Pro Lys Pro Lys
         275                 280                 285            
 Ala Thr Ser Ser Ala Ser Phe Lys Arg Glu Gly Glu Gly Lys Tyr Arg
     290                 295                 300                
 Ala Glu Cys Lys Leu Asp Thr Lys Thr Gly Leu Arg Pro Asp His Arg
 305                 310                 315                 320
 Pro Asp His Lys Leu Gly Ala Lys Thr Gln His Arg Leu Leu Val Val
                 325                 330                 335    
 Pro Glu Asn Glu Asn Arg Met Glu Asp Arg Leu Ala Glu Thr Ser Arg
             340                 345                 350        
 Ala Lys Asp His His Ile Ser Gly Ala Glu Val Gly Lys Ala Ser Thr
         355                 360                 365            



      <210> 1896
      <211> 198
      <212> PRT
      <213> Homo sapiens


      <400> 1896
 Met Phe Ser Leu Thr Asp Arg Leu Asp Val Asp Ser Leu Phe Ser Asn
   1               5                  10                  15    
 Ile Glu Ser Val His Gln Ile Ser Ala Lys Leu Leu Ser Leu Leu Glu
              20                  25                  30        
 Glu Ala Thr Thr Asp Val Glu Pro Ala Met Gln Val Ile Gly Gln Cys
          35                  40                  45            
 Gly Gly Leu Gly Asp Thr Gln Met Gln Gln Leu Glu Asp Gln Asn Ala
      50                  55                  60                
 Asn Val Arg Ser Asn Arg Lys Ala Val Arg Phe Gly Glu Asn Asp Asn
  65                  70                  75                  80
 Gly Glu Met Val Phe Ser Gly Ser Arg Ile His Gln Ser Ser Gln Glu
                  85                  90                  95    
 Arg Lys Asn Gln Gln Glu Ala Glu Leu Tyr Gly Ser Ser Ala Pro Gln
             100                 105                 110        
 Gly Ala Leu Gly Cys Asn Leu Leu Pro Ala His Ser Ser Thr His Gln
         115                 120                 125            
 Glu Val Ala Val Ile Phe Met Asp Lys Ile Phe Tyr Ala Val His Ala
     130                 135                 140                
 Phe Gln Ala Arg Ser Asp His Glu Leu Ser Leu Gln Glu Tyr Gln Arg
 145                 150                 155                 160
 Val His Ile Leu Arg Phe Cys Asp Leu Ser Gly Asn Lys Glu Trp Trp
                 165                 170                 175    
 Leu Ala Glu Ala Gln Gly Gln Lys Gly Tyr Val Pro Ala Asn Tyr Leu
             180                 185                 190        
 Gly Lys Met Thr Tyr Ala
         195            



      <210> 1897
      <211> 84
      <212> PRT
      <213> Homo sapiens


      <400> 1897
 Arg Pro Gly Pro Ala Gly Arg Arg Lys Ala Gly Val Arg Arg Lys Pro
   1               5                  10                  15    
 Lys Ala Asp Pro Ala Ala Ala Gly Leu Ser Arg Pro Pro Pro Lys Val
              20                  25                  30        
 Thr Met Cys Asp Arg Lys Ala Gly Ile Lys Asn Ala Asp Met Ser Glu
          35                  40                  45            
 Lys Met Gln Gln Asp Ser Gly Glu Gly Ala Thr Gln Ala Leu Glu Lys
      50                  55                  60                
 Tyr Asn Ile Lys Lys Asp Ile Ala Ala His Ile Lys Lys Glu Leu Asp
  65                  70                  75                  80
 Lys Lys Ser Asn
                



      <210> 1898
      <211> 39
      <212> PRT
      <213> Homo sapiens


      <400> 1898
 Ile Asn Pro Pro Val Ser Arg Lys Lys Lys Lys Lys Lys Lys Lys Lys
   1               5                  10                  15    
 Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys
              20                  25                  30        
 Lys Lys Lys Gly Gly Gly Leu
          35                



      <210> 1899
      <211> 298
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(298)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1899
 Phe Arg Gly Lys Asp Lys Ala Phe Thr Tyr Asp Phe Val Phe Asp Leu
   1               5                  10                  15    
 Asp Thr Trp Gln Glu Gln Ile Tyr Ser Thr Cys Val Ser Lys Leu Ile
              20                  25                  30        
 Glu Gly Cys Phe Glu Gly Tyr Asn Ala Thr Val Leu Ala Tyr Gly Gln
          35                  40                  45            
 Thr Gly Ala Gly Lys Thr Tyr Thr Met Gly Thr Gly Phe Asp Met Ala
      50                  55                  60                
 Thr Ser Glu Glu Glu Gln Gly Ile Ile Pro Arg Ala Ile Ala His Leu
  65                  70                  75                  80
 Phe Gly Gly Ile Ala Glu Arg Lys Arg Arg Ala Gln Glu Gln Gly Val
                  85                  90                  95    
 Ala Gly Pro Glu Phe Lys Val Ser Ala Gln Phe Leu Glu Leu Tyr Asn
             100                 105                 110        
 Glu Glu Ile Leu Asp Leu Phe Asp Ser Thr Arg Asp Pro Asp Thr Arg
         115                 120                 125            
 His Arg Arg Ser Asn Ile Lys Ile His Glu Asp Ala Asn Gly Gly Ile
     130                 135                 140                
 Tyr Thr Thr Gly Val Thr Ser Arg Leu Ile His Ser Gln Glu Glu Leu
 145                 150                 155                 160
 Ile Gln Cys Leu Lys Gln Gly Ala Leu Ser Arg Thr Thr Ala Ser Thr
                 165                 170                 175    
 Gln Met Asn Val Gln Ser Ser Arg Ser His Ala Ile Phe Thr Ile His
             180                 185                 190        
 Leu Cys Gln Met Arg Met Cys Thr Gln Pro Asp Leu Val Asn Glu Ala
         195                 200                 205            
 Val Thr Gly Leu Pro Glu Trp Thr Pro Pro Ser Ser Glu Tyr Glu Thr
     210                 215                 220                
 Leu Thr Ala Lys Val His Phe Val Asp Leu Ala Gly Ser Lys Arg Leu
 225                 230                 235                 240
 Lys Arg Thr Gly Ala Thr Gly Glu Arg Ala Lys Glu Gly Ile Phe Ile
                 245                 250                 255    
 Asn Cys Gly Leu Leu Ala Leu Gly Asn Val Ile Ser Ala Leu Gly Thr
             260                 265                 270        
 Arg Ala Arg Arg Trp Cys Thr Xaa Leu Gln Asp Ser Lys Leu Thr Arg
         275                 280                 285            
 Phe Xaa Arg Ile Arg Trp Gly Ala Gln Ala
     290                 295            



      <210> 1900
      <211> 793
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(793)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1900
 Met Ala Glu Val Glu Glu Lys Lys Gln Arg Ile Phe Arg Lys Phe Thr
   1               5                  10                  15    
 Tyr Arg Gly Val Asp Leu Gly Gln Leu Leu Asp Met Ser Phe Glu Gln
              20                  25                  30        
 Leu Arg Gln Leu Tyr Gly Ala Arg Gln Leu Arg Arg Leu Asn His Gly
          35                  40                  45            
 Leu Trp Arg Asn Ala Glu Ala Gln Ala Ala Phe Ala Ala Glu Ala Pro
      50                  55                  60                
 Met Leu Gly Gln Glu Gly Gly Ala Asp His Arg Glu Ala Gly Ser Gly
  65                  70                  75                  80
 Glu Asp Ala Pro Ala Gly Tyr Asp His Pro Ser Gln Asp Gly Gly Gln
                  85                  90                  95    
 Gln Gly Gly Arg Leu Gln Arg Gln Asp Leu Gln Pro Gly Gly Asp Gln
             100                 105                 110        
 Ala Gly Asp Asp Arg Pro Arg Pro Gly Arg Val Leu His His Leu Gln
         115                 120                 125            
 Ala Gln Arg Gly Lys Lys Pro Met Ile Ser Thr Val Thr Phe Gly Gln
     130                 135                 140                
 Xaa Pro Asp Pro Pro Leu Arg Ala Gly Gln Arg Leu Xaa Arg Cys Arg
 145                 150                 155                 160
 Leu Leu Ile Tyr Gly Arg Gly Lys Cys Trp Ala Leu Ser Gly Asn Pro
                 165                 170                 175    
 Arg Ser Gly Lys Thr Thr Leu Leu Lys Ser Ile Ser Ala Arg Leu Thr
             180                 185                 190        
 Pro Gln Gln Gly Glu Ile His Tyr Glu Asn Arg Ser Leu Tyr Ala Met
         195                 200                 205            
 Ser Glu Ala Asp Arg Arg Arg Leu Leu Arg Thr Glu Trp Gly Val Val
     210                 215                 220                
 His Gln His Pro Leu Asp Gly Leu Arg Arg Gln Val Ser Ala Gly Gly
 225                 230                 235                 240
 Asn Ile Gly Glu Arg Leu Met Ala Thr Gly Ala Arg His Tyr Gly Asp
                 245                 250                 255    
 Ile Arg Ala Thr Ala Gln Lys Trp Leu Glu Glu Val Glu Ile Pro Ala
             260                 265                 270        
 Asn Arg Ile Asp Asp Leu Pro Thr Thr Phe Leu Arg Ala Thr His Thr
         275                 280                 285            
 Val Lys Met Phe Ser Ile Pro Gly Tyr Ser Ser Pro Gly Gln Leu Leu
     290                 295                 300                
 Asp Pro Glu Thr Asn Ile Asn Ile Gly Thr Ser Tyr Leu Gln Tyr Val
 305                 310                 315                 320
 Tyr Gln Gln Phe Gly Asn Asn Arg Ile Phe Ser Ser Ala Ala Tyr Asn
                 325                 330                 335    
 Ala Gly Pro Gly Arg Val Ala Thr Ala Ile Val Leu Thr Leu Tyr Ile
             340                 345                 350        
 Ile Tyr Met Val Gly Phe Phe Ala Thr Ser Gly Glu Leu Thr Tyr Glu
         355                 360                 365            
 Val Trp Ile Gly Phe Phe Ala Ser Ala Phe Thr Lys Val Phe Thr Leu
     370                 375                 380                
 Leu Ala Leu Phe Ser Ile Leu Ile His Ala Trp Ile Gly Met Trp Gln
 385                 390                 395                 400
 Val Leu Thr Asp Tyr Val Lys Pro Leu Ala Leu Arg Leu Met Leu Gln
                 405                 410                 415    
 Leu Val Ile Val Val Ala Leu Val Val Tyr Val Ile Tyr Gly Phe Val
             420                 425                 430        
 Val Val Trp Gly Met Arg Ala Ala Leu Gln Ile Ser Gln Ser Gly Gln
         435                 440                 445            
 Thr Cys Ala Leu Leu Ser Lys Val Phe Pro Thr Arg Ser His Thr Val
     450                 455                 460                
 Ser Ala Gln Gly Gly Ile Thr Val Ala Leu Gly Asn Thr His Glu Asp
 465                 470                 475                 480
 Asn Trp Glu Trp His Met Tyr Asp Thr Val Lys Gly Ser Asp Tyr Ile
                 485                 490                 495    
 Asp Ala Gly Arg Lys Arg Gln Glu Glu Gly Asp Trp Asn Ser Gly Val
             500                 505                 510        
 Gly Asp Pro Ser Asp Ala Gly Asp Arg Lys His Gln Leu Lys Ala Ala
         515                 520                 525            
 Gln Leu Arg Pro Glu Ala Ile Lys Gln Arg Arg Ile Ala Asn Arg Leu
     530                 535                 540                
 Lys Arg Arg Thr Gln Phe Pro Arg His Leu Lys Gly Phe Val Asn Thr
 545                 550                 555                 560
 Leu Lys Pro Ile His Gly Gly Cys Ser Val Gly Thr Lys Cys Pro Gln
                 565                 570                 575    
 Met Ala Ser Leu Pro Glu Gly Leu His His Pro Val Lys Leu Val Phe
             580                 585                 590        
 Leu Gly Lys Pro Gly Cys Leu Leu Thr Asp Arg Pro Leu Lys Gly Pro
         595                 600                 605            
 Asn Thr Ala Lys Pro Val Ala Val Asp Leu Asn Ala Ser Ala Thr Ala
     610                 615                 620                
 Ile Thr Ser Tyr Ser Leu Tyr Gly Gly Ser Met Ile Leu Leu Phe Leu
 625                 630                 635                 640
 Ala Ser Thr Leu Tyr His Ala Ile Pro His Gln Arg Ala Lys Met Trp
                 645                 650                 655    
 Leu Lys Lys Phe Asp His Cys Ala Ile Tyr Leu Leu Ile Ala Gly Thr
             660                 665                 670        
 Tyr Thr Pro Phe Leu Leu Val Gly Leu Asp Ser Pro Leu Ala Arg Gly
         675                 680                 685            
 Leu Met Ile Val Ile Trp Ser Leu Ala Leu Leu Gly Ile Leu Phe Lys
     690                 695                 700                
 Leu Thr Ile Ala His Arg Phe Lys Ile Leu Ser Leu Val Thr Tyr Leu
 705                 710                 715                 720
 Ala Met Gly Trp Leu Ser Leu Val Val Ile Tyr Glu Met Ala Val Lys
                 725                 730                 735    
 Leu Ala Ala Gly Ser Val Thr Leu Leu Ala Val Gly Gly Val Val Tyr
             740                 745                 750        
 Ser Leu Gly Val Ile Phe Tyr Val Cys Lys Arg Ile Pro Tyr Asn His
         755                 760                 765            
 Ala Ile Trp His Thr Val Thr Ala Glu His Glu Asp Tyr Arg Asn Ala
     770                 775                 780                
 Ile Phe Tyr Leu Phe Asp Phe Tyr Asp
 785                 790            



      <210> 1901
      <211> 114
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(114)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1901
 Asn Leu Cys Gln Val Phe Ile Pro Phe Leu Phe His Ser Leu Leu Tyr
   1               5                  10                  15    
 Val Phe Lys Thr Ile Leu Lys Gly Leu Phe Gln Ala Ser Phe Leu Gly
              20                  25                  30        
 His Leu Leu Leu Leu Pro Leu Ser Gly Thr Pro Gly Arg Pro Gly Gly
          35                  40                  45            
 Gly Gly Ala Gly Gly Ser Gly Arg Gly Asp Pro Pro Ala Ala Gly Ala
      50                  55                  60                
 Ser Arg Thr Ile Pro Trp Pro Leu Leu Leu Gln Gln Leu Ser Ser Ser
  65                  70                  75                  80
 Ser Ser His Phe Lys Ala Pro Ser Lys Leu Ser Ser His Gly Xaa Pro
                  85                  90                  95    
 Arg Ala Leu Gly Pro Pro Gly Pro Tyr His Arg Pro Pro Ser Pro Gly
             100                 105                 110        
 Thr Thr
        



      <210> 1902
      <211> 252
      <212> PRT
      <213> Homo sapiens


      <400> 1902
 Met Val Gln Glu Lys Asn Thr Ala Gly Ala Leu Gly Leu Leu Thr Glu
   1               5                  10                  15    
 Leu Gln Asn Val Leu Glu Leu Leu Arg Ser Thr Gly Thr Gly Met Leu
              20                  25                  30        
 Leu Asn Val Ser Leu Lys Gln Ser Ala Asp Glu Glu Val Thr Ser Leu
          35                  40                  45            
 Ala Lys Ser Leu Val Lys Ser Trp Lys Lys Leu Pro Asp Lys Pro Ser
      50                  55                  60                
 Ser Glu Lys Asp Pro Lys Glu Lys Gln Ile Glu Pro Ala Met Thr Ser
  65                  70                  75                  80
 Gln Asn Ser Lys Arg Asn Thr Ser Asp Ser Val Arg Met Lys Tyr Arg
                  85                  90                  95    
 Glu Met Leu Pro Ala Ala Leu Arg Thr Gly Asp Asp Cys Ile Glu Met
             100                 105                 110        
 Gly Thr Asp Glu Glu Glu Leu Gly Ser Arg Thr Glu Glu Ala Ile Asp
         115                 120                 125            
 Pro Glu Arg Gly Asn Thr Gly Met Lys Tyr Lys Asn Arg Val Gln Ser
     130                 135                 140                
 Lys Ile Ser Asn Leu Thr Asp Ala Lys Asn Pro Asp Leu Arg Lys Asn
 145                 150                 155                 160
 Ala Pro Cys Gly Asn Ile Pro Pro Asp Leu Leu Ala Arg Met Thr Ala
                 165                 170                 175    
 Glu Glu Met Ala Ser Asp Glu Leu Lys Glu Met His Lys Asn Leu Arg
             180                 185                 190        
 Lys Glu Ala Ile Arg Glu His Gln Met Ala Lys Thr Gly Gly Thr Gln
         195                 200                 205            
 Pro Asp Ser Leu Thr Cys Ala Lys Cys Lys Lys Lys Asn Cys Thr Ser
     210                 215                 220                
 Thr Gln Val Gln Ala Cys Ser Ala Gly Glu Pro Met Thr Thr Phe Val
 225                 230                 235                 240
 Asp Cys Asn Glu Cys Gly Asn Gln Gln Lys Phe Cys
                 245                 250        



      <210> 1903
      <211> 207
      <212> PRT
      <213> Homo sapiens


      <400> 1903
 Asn Ser Phe Thr Ser Ser Ser Glu Phe Val Ile His Gln Arg Ile His
   1               5                  10                  15    
 Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Val
              20                  25                  30        
 Gly Asn Ser Pro Leu Leu Arg His Gln Lys Ile His Thr Gly Glu Lys
          35                  40                  45            
 Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ser Phe Gly Arg Thr Ser His
      50                  55                  60                
 Leu Ser Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Ser Cys
  65                  70                  75                  80
 Lys Val Cys Gly Gln Ala Phe Asn Phe His Thr Lys Leu Thr Arg His
                  85                  90                  95    
 Gln Arg Ile His Ser Glu Glu Lys Pro Phe Asp Cys Val Asp Cys Gly
             100                 105                 110        
 Lys Ala Phe Ser Ala Gln Glu Gln Leu Lys Arg His Leu Arg Ile His
         115                 120                 125            
 Thr Gln Glu Ser Ser Tyr Val Cys Asp Glu Cys Gly Lys Ala Leu Thr
     130                 135                 140                
 Ser Lys Arg Asn Leu His Gln His Gln Arg Ile His Thr Gly Glu Lys
 145                 150                 155                 160
 Pro Tyr Glu Cys Ser Lys Tyr Glu Lys Ala Phe Gly Thr Ser Ser Gln
                 165                 170                 175    
 Leu Gly His Leu Glu His Val Tyr Ser Gly Glu Lys Pro Val Leu Asp
             180                 185                 190        
 Ile Cys Arg Phe Gly Leu Pro Glu Phe Phe Thr Pro Phe Tyr Trp
         195                 200                 205        



      <210> 1904
      <211> 127
      <212> PRT
      <213> Homo sapiens


      <400> 1904
 Ile Asp Arg Leu Arg Leu Asp Lys Tyr Tyr Met Leu Ile Arg Leu Val
   1               5                  10                  15    
 Leu Arg Gln Ser Phe Glu Val Leu Lys Arg Asn Gly Trp Glu Glu Ser
              20                  25                  30        
 Arg Ile Lys Val Phe Leu Asp Val Leu Met Lys Glu Val Leu Cys Pro
          35                  40                  45            
 Glu Ser Gln Ser Pro Asn Gly Val Arg Phe His Phe Ile Asp Ile Tyr
      50                  55                  60                
 Leu Asp Glu Leu Ser Lys Val Gly Gly Lys Glu Leu Leu Ala Asp Gln
  65                  70                  75                  80
 Asn Leu Lys Phe Ile Asp Pro Phe Cys Lys Ile Ala Ala Lys Thr Lys
                  85                  90                  95    
 Asp His Thr Leu Val Gln Thr Ile Ala Arg Gly Val Phe Glu Ala Ile
             100                 105                 110        
 Val Asp Gln Ser Pro Phe Val Pro Glu Glu Thr Met Glu Glu Gln
         115                 120                 125        



      <210> 1905
      <211> 530
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(530)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1905
 Leu Arg Asp Cys Lys Arg Ile Asn Gln His Pro Val Lys Thr Asp Gln
   1               5                  10                  15    
 Ser Ala Phe Cys Lys Met Ala Pro Ile Met Gln Asp Val Val Leu Glu
              20                  25                  30        
 Val Leu Ala Arg Ala Ile Arg Gln Glu Lys Glu Ile Lys Gly Ile Gln
          35                  40                  45            
 Leu Gly Lys Glu Glu Val Lys Leu Ser Leu Phe Ala Asp Asp Met Ile
      50                  55                  60                
 Val Tyr Leu Glu Asn Pro Ile Val Ser Ala Gln Asn Leu Leu Lys Leu
  65                  70                  75                  80
 Ile Ser Asn Phe Ser Lys Val Ser Gly Tyr Lys Ile Asn Ala Gln Lys
                  85                  90                  95    
 Ser Gln Ala Phe Leu Tyr Thr Asn Asn Arg Gln Thr Glu Ser Gln Ile
             100                 105                 110        
 Met Ser Glu Leu Pro Phe Thr Ile Ala Ser Lys Arg Ile Lys Tyr Leu
         115                 120                 125            
 Gly Ile Gln Leu Thr Arg Asp Val Lys Asp Leu Phe Lys Glu Asn Tyr
     130                 135                 140                
 Lys Pro Leu Leu Lys Glu Ile Thr Glu Asp Thr Asn Lys Trp Lys Asn
 145                 150                 155                 160
 Ile Pro Cys Ser Trp Val Gly Arg Ile Asn Ile Val Lys Met Ala Ile
                 165                 170                 175    
 Leu Pro Lys Val Ile Tyr Arg Phe Asn Ala Ile Pro Ile Lys Leu Pro
             180                 185                 190        
 Met Thr Phe Phe Thr Glu Leu Glu Lys Thr Thr Leu Lys Phe Ile Trp
         195                 200                 205            
 Asn Gln Lys Arg Ala Arg Met Ala Lys Ser Ile Leu Ser Gln Lys Asn
     210                 215                 220                
 Lys Ala Gly Gly Ile Thr Leu Pro Asp Phe Lys Leu Tyr Tyr Lys Ala
 225                 230                 235                 240
 Thr Val Thr Lys Thr Ala Trp Tyr Trp Tyr Gln Asn Arg Asp Val Asp
                 245                 250                 255    
 Gln Trp Asn Arg Thr Glu Pro Ser Glu Ile Thr Pro His Ile Tyr Asn
             260                 265                 270        
 Tyr Leu Ile Phe Asp Lys Pro Asp Lys Asn Lys Gln Trp Gly Lys Asp
         275                 280                 285            
 Ser Leu Phe Asn Lys Trp Gly Trp Glu Asn Trp Leu Ala Ile Cys Arg
     290                 295                 300                
 Lys Leu Lys Leu Asp Pro Phe Leu Thr Pro Tyr Thr Arg Ile Asn Ser
 305                 310                 315                 320
 Arg Trp Ile Lys Asp Leu Asn Val Arg Pro Lys Thr Ile Lys Thr Leu
                 325                 330                 335    
 Glu Glu Asn Leu Asp Ile Thr Ile Gln Asp Ile Gly Met Gly Lys Asp
             340                 345                 350        
 Phe Met Ser Lys Thr Pro Lys Ala Met Ala Thr Lys Ala Lys Ile Asp
         355                 360                 365            
 Lys Trp Asp Leu Ile Lys Leu Lys Ser Phe Cys Ile Ala Lys Glu Thr
     370                 375                 380                
 Thr Ile Arg Val Asn Arg Gln Pro Thr Lys Trp Glu Lys Ile Phe Ala
 385                 390                 395                 400
 Thr Tyr Ser Pro Asp Lys Gly Leu Ile Ser Arg Ile Tyr Asn Glu Leu
                 405                 410                 415    
 Lys Gln Ile Tyr Lys Lys Lys Thr Asn Asn Pro Ile Lys Lys Trp Ala
             420                 425                 430        
 Lys Asp Met Asn Arg His Phe Ser Lys Glu Asp Ile Tyr Ala Ala Lys
         435                 440                 445            
 Lys His Met Lys Arg Cys Ser Ser Ser Leu Ala Ile Arg Glu Ile Gln
     450                 455                 460                
 Ile Lys Thr Thr Met Arg Tyr His Leu Thr Pro Val Arg Met Ala Ile
 465                 470                 475                 480
 Ile Lys Lys Ser Gly Asn Asn Arg Cys Phe Xaa Trp Gln Lys Pro Gly
                 485                 490                 495    
 Pro Ser Gly Xaa Ala Leu Arg Ser Trp Lys Glu Asp Ile Ala Gly Thr
             500                 505                 510        
 Ser Tyr Val Gly Met Asn Gln Cys Gln Met Arg Lys Asn Thr Lys Thr
         515                 520                 525            
 Leu Ile
     530



      <210> 1906
      <211> 96
      <212> PRT
      <213> Homo sapiens


      <400> 1906
 Gln Met Val Pro Ser Pro His Ser Gly Glu Val Lys Gly Ser Lys Pro
   1               5                  10                  15    
 Thr Leu Leu Cys Leu Leu Cys Ser Arg Phe Lys Thr Leu Met Thr Asn
              20                  25                  30        
 Lys Ser Glu Gln Asp Gly Asp Ser Ser Lys Thr Ile Glu Ile Ser Asp
          35                  40                  45            
 Met Lys Tyr His Ile Phe Gln Val Cys Gly Ser Trp Cys Arg Pro Leu
      50                  55                  60                
 Leu Arg Gly Met Thr Leu Pro Gln Glu Pro Thr Leu Trp Ala Ala Val
  65                  70                  75                  80
 His Trp Leu Ser Leu Phe Thr Leu Phe Pro Val Pro Ser Val Phe Cys
                  85                  90                  95    





      <210> 1907
      <211> 88
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(88)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1907
 Ala Arg Asp Tyr His Ser Gly Glu Asn Leu Tyr Leu Pro Cys Phe Ala
   1               5                  10                  15    
 Asp Ser Asn Pro Pro Ala Glu Tyr Ser Trp Thr Ile Asn Gly Lys Phe
              20                  25                  30        
 Gln Leu Ser Gly Gln Lys Leu Phe Ile Pro His Ile Thr Thr His His
          35                  40                  45            
 Thr Gly Pro Ser Pro Cys Ser Asp Arg Asn Ser Pro Thr Gly Met Gln
      50                  55                  60                
 Ser Ser Lys Phe Met Thr Val Asn Ala Ser Ala Pro Ser Arg Pro Xaa
  65                  70                  75                  80
 His Leu Pro Gly Leu Asn Pro Leu
                  85            



      <210> 1908
      <211> 88
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(88)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1908
 Ala Arg Asp Tyr His Ser Gly Glu Asn Leu Tyr Leu Pro Cys Phe Ala
   1               5                  10                  15    
 Asp Ser Asn Pro Pro Ala Glu Tyr Ser Trp Thr Ile Asn Gly Lys Phe
              20                  25                  30        
 Gln Leu Ser Gly Gln Lys Leu Phe Ile Pro His Ile Thr Thr His His
          35                  40                  45            
 Thr Gly Pro Ser Pro Cys Ser Asp Arg Asn Ser Pro Thr Gly Met Gln
      50                  55                  60                
 Ser Ser Lys Phe Met Thr Val Asn Ala Ser Ala Pro Ser Arg Pro Xaa
  65                  70                  75                  80
 His Leu Pro Gly Leu Asn Pro Leu
                  85            



      <210> 1909
      <211> 769
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(769)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1909
 Asp Leu Glu Leu Glu Trp Ser Gly Phe Asp Trp Val Arg Ser Ile Asp
   1               5                  10                  15    
 Gly Asp Phe Ser Gly Asn Ile Arg Thr Pro Leu Phe Leu His Ser Ser
              20                  25                  30        
 Thr Asp Arg Arg Ser Leu Pro Phe Trp Cys Pro Gly Ser Leu Asp Ser
          35                  40                  45            
 Val Arg Met Leu Leu Ser Leu Phe Cys Phe Asp Gly Thr Ala Gly Asp
      50                  55                  60                
 Ser Lys Val Gly Glu Pro Thr Trp Glu Val Pro Pro Pro Gly Pro Gly
  65                  70                  75                  80
 Cys Xaa Gln Gly Arg Pro Thr Cys Val Met Arg Pro Ala Gly Thr Pro
                  85                  90                  95    
 Ala Leu Gly Arg Pro Gln Xaa Glu Ala Ala Arg Val Pro Val Glu Met
             100                 105                 110        
 Pro Ala Arg Glu Pro Gly Asp Glu Lys Pro Pro Ala Pro Phe Pro Xaa
         115                 120                 125            
 Pro Ala Pro Leu Cys Ser Ser Gly Ser Leu Val Ile Trp Asp Gly Ser
     130                 135                 140                
 Glu Ile Ser Pro Xaa Val Asp Glu Lys Ser Cys Ser Xaa Ser Pro Ala
 145                 150                 155                 160
 Ser Ser Glu Cys Gly Arg Glu Pro Ser Phe Pro Leu Pro Gly Ser Pro
                 165                 170                 175    
 Trp Lys Gly Trp Ser Ser Trp Asn Gly Gln Ala Pro Pro Leu Ala Pro
             180                 185                 190        
 Pro Ala Gln Gly Pro Leu Leu Pro Val Pro Leu Ser Ala Gly Pro Gly
         195                 200                 205            
 Val Ala Gly Glu Arg Thr Val Pro Ser Ser Pro Arg Trp Trp Arg Pro
     210                 215                 220                
 His Leu Phe Leu Ala Pro Thr Ala Pro Ser Pro Pro Pro Cys Pro Thr
 225                 230                 235                 240
 Val Ser Ala Pro Gly His Leu Leu Gly Val Ala Gln Lys Pro Asp Cys
                 245                 250                 255    
 His Pro Pro Ala Ser Gln Arg Pro Arg Arg His Pro Leu Pro Phe Leu
             260                 265                 270        
 Pro Gly Glu Ala Phe Ala Glu Xaa Leu Gln Ile His Lys Phe Leu Pro
         275                 280                 285            
 Phe Leu Leu His Ser Arg Phe Leu Asp Leu Leu Arg Gly Pro Trp Ile
     290                 295                 300                
 Ser Thr Lys Ser Ser Leu Pro Pro Leu His Leu Pro Thr Leu Thr Ser
 305                 310                 315                 320
 Arg Val Pro Gly Lys Phe Ser Ala Leu Leu Ser Asn Ser Leu Leu Pro
                 325                 330                 335    
 Ser Pro Pro Met Val Cys Pro Leu Ser Gln Trp Gln Xaa Ala Pro Val
             340                 345                 350        
 Arg His Arg Xaa Thr Ser Ser Leu Thr Pro Asn Leu Trp Ala Arg Glu
         355                 360                 365            
 Leu Ser Ser Glu Leu Arg Pro Gly Gly Arg Pro Val Ser Ala Val Xaa
     370                 375                 380                
 Arg Xaa Cys Arg Asn Val Arg Ala Ala Ser Val Leu Thr Ser Pro Ser
 385                 390                 395                 400
 Arg Thr Pro Leu Gly Gln Asn Pro Val Leu Tyr Ser Gly Glu Ala Phe
                 405                 410                 415    
 Ile Val His Ile Leu Asp Glu Glu Arg Ala Ser Gly Ile Lys His Glu
             420                 425                 430        
 Leu Val Gly Val Lys His Leu Pro Ala Ser Pro Ser Glu Thr Gly His
         435                 440                 445            
 His Ser Gly Val Gly Tyr Xaa Pro Trp Arg Gln Ser Pro Ala Thr Ser
     450                 455                 460                
 Ser Pro Arg Glu Ser Lys Val Arg Pro Pro Leu Ser Gly Cys Leu Ser
 465                 470                 475                 480
 Cys Asp Gly Thr Thr Asn Pro Val Arg Gly Arg Pro Pro Gly Thr Thr
                 485                 490                 495    
 Ser Asn Pro Ala Val Pro Ser Glu Pro Ala Arg Pro Pro Leu Pro Gly
             500                 505                 510        
 His Gly Leu Ala His Arg Val Pro Pro Ser Pro Gly Pro Arg Gly Pro
         515                 520                 525            
 Ala Gly Pro Gly Ala Pro Ser Gly Ser Ala Glu Gly Asp Gly Pro Leu
     530                 535                 540                
 Glu Pro Gln Pro Ala Val Gly Val Pro Trp Arg Arg Gly Xaa Pro Ser
 545                 550                 555                 560
 Leu Ala Pro Ala Leu Ser Ala Gln Val Ala Pro Glu Ala Ala Arg Ala
                 565                 570                 575    
 Pro Ala Xaa Gly Pro Gly Gln Ala Ala Gly Ala Arg Glu Glu Gly Pro
             580                 585                 590        
 Ala Trp Pro Cys Lys Ser Pro Pro Trp Pro Arg Pro Gln Ser Val Pro
         595                 600                 605            
 Ala Leu Pro Gln Lys Ala Leu Leu Ala Phe Arg Trp Glu Glu Val Ala
     610                 615                 620                
 Gly Pro Leu Phe Pro Thr Leu Pro Leu Lys Ser Cys Trp Gln Glu Val
 625                 630                 635                 640
 Val Ala Cys Xaa Thr Ile Pro Leu Pro Gln Arg Gly Ala Gly Pro His
                 645                 650                 655    
 Gly Pro Leu Ser Val Gly Leu Trp Phe Gln Ser Pro Gly Leu Thr Thr
             660                 665                 670        
 Met Gly Gly Ile Pro Gly Val Ser Ser Cys Asp Phe Tyr Ser Pro Gly
         675                 680                 685            
 Pro Ala Ala Trp Pro Leu Pro Gly Ser Leu Phe Xaa Ser His Lys Pro
     690                 695                 700                
 Ala Ser Gly Leu Ile Leu Ser Glu Lys Ala Leu Pro Ala Xaa Ala Leu
 705                 710                 715                 720
 Val Gln Pro His Pro Ala Pro Ser Pro Thr Gly Thr Glu Pro Trp Pro
                 725                 730                 735    
 Pro Ala Gly Pro Arg Thr Val Pro Arg Pro Pro Ser Ala Ser Ser Val
             740                 745                 750        
 Ala Pro Ser Cys Trp Trp Val Leu Ser Val Ser Asp Leu Tyr Cys Asp
         755                 760                 765            
 His
    



      <210> 1910
      <211> 94
      <212> PRT
      <213> Homo sapiens


      <400> 1910
 Asn Gly Ile Pro Asp Phe Ser Asn Thr Thr Leu Leu Arg Gly Leu Gln
   1               5                  10                  15    
 Met Pro Gly Ala Arg Gly Pro Cys Cys Gly Ser Gln Arg His Ile Asn
              20                  25                  30        
 Leu Leu Met Gly Thr Gly Val Phe Leu Val Lys Met Lys Ala Asn Glu
          35                  40                  45            
 Phe Phe Phe Leu Asp Ser Glu Thr Arg Leu Cys Lys Ile Ala Pro Glu
      50                  55                  60                
 Gly Trp Arg Glu Gln Pro Gln Lys Thr Ser Met Asn Thr Phe Thr Leu
  65                  70                  75                  80
 Phe Leu Arg Ile Lys Phe Phe Val Ser His Tyr Gly Leu Leu
                  85                  90                



      <210> 1911
      <211> 173
      <212> PRT
      <213> Homo sapiens


      <400> 1911
 Gly Ser Ser Gln Cys Gly His Glu Gly Ala Ala Tyr Trp Ala Asp Ala
   1               5                  10                  15    
 Val Thr Leu Glu Ser Ala Ser Pro Ala Ser Pro Pro Ala Arg Asn Met
              20                  25                  30        
 Trp Leu Arg Leu Gly Pro Pro Ser Leu Ser Leu Ser Pro Lys Pro Thr
          35                  40                  45            
 Val Gly Arg Ser Leu Cys Leu Thr Leu Trp Phe Leu Ser Leu Ala Leu
      50                  55                  60                
 Arg Ala Ser Thr Gln Ala Pro Ala Pro Thr Val Asn Thr His Phe Gly
  65                  70                  75                  80
 Lys Leu Arg Gly Ala Arg Val Pro Leu Pro Ser Glu Ile Leu Gly Pro
                  85                  90                  95    
 Val Asp Gln Tyr Leu Gly Val Pro Tyr Ala Ala Pro Pro Ile Gly Glu
             100                 105                 110        
 Lys Arg Phe Leu Pro Pro Glu Pro Pro Pro Ser Trp Ser Gly Ile Arg
         115                 120                 125            
 Asn Ala Thr His Phe Pro Pro Val Cys Pro Gln Asn Ile His Thr Ala
     130                 135                 140                
 Val Pro Glu Val Met Leu Pro Val Trp Phe Thr Ala Asn Leu Asp Ile
 145                 150                 155                 160
 Val Ala Thr Tyr Ile Gln Glu Pro Asn Glu Asp Cys Leu
                 165                 170            



      <210> 1912
      <211> 36
      <212> PRT
      <213> Homo sapiens


      <400> 1912
 Lys Lys Gly Ala Gly Gln Val Val Asp Asp Val Gln Leu Ala Gln Arg
   1               5                  10                  15    
 Leu Ala Gln Ala Asn Glu Ile Val Leu Ser Trp Asn Cys Trp Met Leu
              20                  25                  30        
 Cys Lys Gln Tyr
          35    



      <210> 1913
      <211> 310
      <212> PRT
      <213> Homo sapiens


      <400> 1913
 Ser Phe Val Cys Glu Val Gly Leu Gly Asn Ser Ser Ser Asn Met Asn
   1               5                  10                  15    
 Ile Arg Gly Asp Thr Gly His Lys Ala Cys Glu Cys Gln Glu Tyr Gly
              20                  25                  30        
 Pro Lys Pro Trp Lys Ser Gln Gln Pro Lys Lys Ala Phe Arg Tyr His
          35                  40                  45            
 Pro Ser Leu Arg Thr Gln Glu Arg Asp His Thr Gly Lys Lys Pro Tyr
      50                  55                  60                
 Ala Cys Lys Glu Cys Gly Lys Asn Ile Ile Tyr His Ser Ser Ile Gln
  65                  70                  75                  80
 Arg His Met Val Val His Ser Gly Asp Gly Pro Tyr Lys Cys Lys Phe
                  85                  90                  95    
 Cys Gly Lys Ala Phe His Cys Leu Ser Leu Tyr Leu Ile His Glu Arg
             100                 105                 110        
 Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ser
         115                 120                 125            
 Phe Ser Tyr Ser Ala Thr His Arg Ile His Glu Arg Thr His Ile Gly
     130                 135                 140                
 Glu Lys Pro Tyr Glu Cys Gln Glu Cys Gly Lys Ala Phe His Ser Pro
 145                 150                 155                 160
 Arg Ser Cys His Arg His Glu Arg Ser His Met Gly Glu Lys Ala Tyr
                 165                 170                 175    
 Gln Cys Lys Glu Cys Gly Lys Ala Phe Met Cys Pro Arg Tyr Val Arg
             180                 185                 190        
 Arg His Glu Arg Thr His Ser Arg Lys Lys Leu Tyr Glu Cys Lys Gln
         195                 200                 205            
 Cys Gly Lys Ala Leu Ser Ser Leu Thr Ser Phe Gln Thr His Ile Arg
     210                 215                 220                
 Met His Ser Gly Glu Arg Pro Tyr Glu Cys Lys Thr Cys Gly Lys Gly
 225                 230                 235                 240
 Phe Tyr Ser Ala Lys Ser Phe Gln Arg His Glu Lys Thr His Ser Gly
                 245                 250                 255    
 Glu Lys Pro Tyr Lys Cys Lys Gln Cys Gly Lys Ala Phe Thr Arg Ser
             260                 265                 270        
 Gly Ser Phe Arg Tyr His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr
         275                 280                 285            
 Glu Cys Lys Gln Cys Gly Lys Ala Phe Arg Ser Ala Pro Asn Leu Gln
     290                 295                 300                
 Ser His Gly Arg Thr His
 305                 310



      <210> 1914
      <211> 457
      <212> PRT
      <213> Homo sapiens


      <400> 1914
 Met Ala Phe Lys Glu Ile Lys Lys Ala Leu Ile His Ala Leu Ala Leu
   1               5                  10                  15    
 Gly Leu Pro Asp Met Thr Lys Pro Phe Tyr Val Tyr Ile Tyr Glu Arg
              20                  25                  30        
 Lys Gly Ile Ser Ile Arg Val Leu Val Gln Thr Leu Gly Ser Trp Tyr
          35                  40                  45            
 Trp Pro Val Ala Cys Leu Ser Gln Arg Leu Asp Leu Val Ala Met Gly
      50                  55                  60                
 Trp Pro Pro Cys Phe Lys Ala Val Ala Ala Thr Ala Leu Leu Ala Glu
  65                  70                  75                  80
 Asp Ala Asn Lys Leu Thr Phe Gly Gln Arg Leu Ile Ile Gln Val Pro
                  85                  90                  95    
 His Thr Ile Val Thr Leu Met Gly Gln Arg Gly His Gly Trp Leu Ser
             100                 105                 110        
 Asn Pro Arg Met Leu Arg Tyr Gln Glu Leu Leu Cys Gly Asn Pro Tyr
         115                 120                 125            
 Ile Ile Leu Val Thr Leu Asn Thr Leu Asp Pro Arg Thr Leu Leu Pro
     130                 135                 140                
 Lys Glu Trp Ala Glu His Arg Lys Pro Pro Leu Cys Cys Pro Ala Gln
 145                 150                 155                 160
 Arg Val Glu Leu Thr Ala Leu Thr Arg Ala Ser Leu Val Ala Lys Gly
                 165                 170                 175    
 Lys Ser Val Asn Ile Tyr Thr Asp Pro Arg Cys Ala Phe Ala Ile Leu
             180                 185                 190        
 His Ser His Gly Ala Ile Trp Ala Asn Met Ala Pro Arg Asp Ser Arg
         195                 200                 205            
 Asn Trp Thr Thr Pro Cys Glu Asn Leu Pro Val Asp Phe Ile Glu Leu
     210                 215                 220                
 Pro Gln Val Gly Gly Cys Arg Tyr Met Leu Val Phe Val Cys Thr Phe
 225                 230                 235                 240
 Ser Ser Ser Val Lys Val Glu Arg Met Lys Glu Thr Leu Lys Gln Leu
                 245                 250                 255    
 Leu Lys Val Leu Pro Gly Asn Leu Ser Lys Val Lys Ser Gly Ala Ala
             260                 265                 270        
 His Gly Pro Ser Val Ser Gln Arg His Pro Thr Lys Leu Thr Gly Tyr
         275                 280                 285            
 Ser Pro Tyr Glu Met Val Phe Gly Ser Pro Pro Thr Ile Ile Thr Gln
     290                 295                 300                
 Ile Lys Gly Asp Leu Lys Glu Ile Gly Glu Leu Thr Leu Arg Arg Gln
 305                 310                 315                 320
 Met Gln Ala Leu Gly Glu Ala Met Gln Glu Ile Gln Arg Tyr His Thr
                 325                 330                 335    
 Leu Gly Ser Ser Gln Pro Ala Glu Thr Ser Ser Asp His Asn Ser Gly
             340                 345                 350        
 Pro Ala Ala Ser Gln Gln Asn Pro Asp Tyr Pro Lys Gln Leu Ile Leu
         355                 360                 365            
 Arg Gln Asn Tyr Ala Thr Ala Asp Lys Asp Asn Cys Pro Ala Leu Thr
     370                 375                 380                
 Ile Pro Glu Ala Glu Ile Arg Val Ser Lys Pro Val Asn Lys Lys Glu
 385                 390                 395                 400
 Val Phe Pro His Ser His Lys Gly Pro Val Ser Ile His Phe Asp Ala
                 405                 410                 415    
 Cys Gln Ala Ser His Leu Ser Lys Leu Asn Thr Ile Gly Thr Ile Arg
             420                 425                 430        
 Lys Asn Leu Gly Gln Glu Arg Val Ser Gln Gln Ser Tyr Gln Gly Cys
         435                 440                 445            
 Asn Arg Lys Ile Gln Lys Gly Val Pro
     450                 455        



      <210> 1915
      <211> 115
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(115)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1915
 Glu Leu His Tyr Pro Asp Gly Tyr Gly Asp Ala Leu Gln Gly Leu Gly
   1               5                  10                  15    
 Gln Ser Ser Asp Leu Thr Trp Arg Asp Ile Met Leu Leu Leu Asn Gln
              20                  25                  30        
 Thr Leu Thr Pro Asn Glu Arg Ser Ala Ile Ile Thr Ala Ala Arg Glu
          35                  40                  45            
 Phe Gly Asp Leu Trp Tyr Ser Gln Val Asn Asp Arg Met Thr Thr Glu
      50                  55                  60                
 Glu Xaa Glu Arg Phe Pro Thr Gly Gln Gln Ala Val Pro Ser Val Asp
  65                  70                  75                  80
 Pro His Trp Asp Thr Glu Ser Glu His Thr Asp Trp Cys Arg Lys His
                  85                  90                  95    
 Leu Leu Pro Cys Val Leu Glu Gly Leu Thr Lys Thr Arg Lys Lys Leu
             100                 105                 110        
 Met Asn Tyr
         115



      <210> 1916
      <211> 380
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(380)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1916
 Gly Lys Ser Ser Gln Trp Ala Glu Leu Gln Ala Val Tyr Leu Val Val
   1               5                  10                  15    
 His Phe Glu Trp Lys Glu Lys Xaa Pro Asp Val Xaa Leu Tyr Ser Asp
              20                  25                  30        
 Ser Arg Ala Val Ala Ser Gly Leu Ala Gly Trp Ser Gly Thr Trp Lys
          35                  40                  45            
 Lys His Asp Trp Lys Ile Gly Asp Glu Glu Ile Trp Gly Thr Gly Met
      50                  55                  60                
 Trp Met Asp Leu Phe Lys Trp Ser Lys Thr Val Lys Ile Phe Ala Ser
  65                  70                  75                  80
 His Val Ser Ala His Gln Arg Val Ile Pro Ala Glu Glu Asp Phe Asn
                  85                  90                  95    
 Asn Gln Val Asp Arg Met Thr Arg Ser Val Asp Ser Leu Gln Pro Leu
             100                 105                 110        
 Ser Pro Ala Thr Ser Val Ile Met Gln Cys Ala Cys Glu Gln Asn Gly
         115                 120                 125            
 His Ser Gly Arg Asp Gly Val Tyr Ala Trp Ala Gln Gln His Gly Leu
     130                 135                 140                
 Pro Leu Thr Lys Ala Asp Leu Ala Thr Ala Thr Ala Glu Cys Pro Val
 145                 150                 155                 160
 Cys Gln Gln Gln Arg Leu Thr Pro Ser Pro Ser Ile Leu Gly Thr Ile
                 165                 170                 175    
 Pro Trp Cys Asp Gln Pro Ala Thr Trp Trp Gln Val Asp Tyr Ile Gly
             180                 185                 190        
 Leu Leu Pro Ser Trp Lys Arg Gln Trp Phe Val Leu Thr Gly Ile Asp
         195                 200                 205            
 Thr Tyr Ser Gly Tyr Gly Phe Ala Tyr Pro Ala Arg Asn Ala Ser Ala
     210                 215                 220                
 Lys Thr Thr Ile Arg Gly Val Ser Glu Cys Leu Ile His His His Gly
 225                 230                 235                 240
 Ile Pro His Ser Thr Ala Ser Asp Gln Gly Thr His Phe Thr Ala Lys
                 245                 250                 255    
 Glu Val Trp Gln Trp Ala Tyr Ala His Gly Ile His Trp Ser Tyr His
             260                 265                 270        
 Val Leu His His Pro Glu Glu Ala Gly Lys Glu Arg Trp Asn Gly Leu
         275                 280                 285            
 Leu Lys Ser Gln Leu Gln Cys Gln Leu Gly Asp Asn Thr Leu Gln Gly
     290                 295                 300                
 Xaa Gly Lys Val Leu Gln Gln Ala Val Tyr Val Leu Asn Xaa His Pro
 305                 310                 315                 320
 Ile Tyr Gly Thr Val Ser Pro Ile Ala Arg Ile His Gly Ser Arg Asn
                 325                 330                 335    
 Gln Gly Val Glu Thr Glu Leu Thr Pro Leu Thr Ile Thr Pro Ser Asp
             340                 345                 350        
 Pro Leu Ala Lys Phe Leu Leu Pro Val Pro Pro Thr Leu His Ser Ala
         355                 360                 365            
 Gly Leu Glu Ile Leu Val Pro Glu Gly Glu Ile Arg
     370                 375                 380



      <210> 1917
      <211> 115
      <212> PRT
      <213> Homo sapiens


      <400> 1917
 Arg Pro Thr Arg Pro Pro Thr Arg Pro Glu Glu Ile Lys Asn Leu Ile
   1               5                  10                  15    
 Leu Pro Tyr Ile Ser Asp Met Asn Phe Val Gln Asp Leu Cys Glu Asp
              20                  25                  30        
 Phe Tyr Glu Leu Phe Lys Thr Asp Lys Gly Phe Asp Lys Ala Thr Phe
          35                  40                  45            
 Glu Ser Gln Met Ser Val Met Arg Gly Gln Ile Leu Asn Leu Thr Gln
      50                  55                  60                
 Ala Leu Arg Asp Gly Lys Ser Pro Phe Gln Leu Val Gln Ile Pro Cys
  65                  70                  75                  80
 Val Ile Val Glu Arg Ser Gln Gly Gly Ser Gln Gly Arg Ile Val His
                  85                  90                  95    
 Leu Ser Asn Ser Phe Thr Gln Thr Val Asn Cys Arg Lys Pro Phe Phe
             100                 105                 110        
 Ser Ser Trp
         115



      <210> 1918
      <211> 74
      <212> PRT
      <213> Homo sapiens


      <400> 1918
 Asn Met Ile Leu Leu Lys Lys Arg Arg Leu Leu Ile Asn Ser Leu Gly
   1               5                  10                  15    
 Glu Gly Thr Ile Asn Gly Leu Leu Asp Glu Leu Leu Glu Thr Asn Val
              20                  25                  30        
 Leu Ser Gln Glu Asp Thr Glu Ile Val Lys Cys Glu Asn Val Thr Val
          35                  40                  45            
 Ile Asp Lys Ala Arg Asp Leu Leu Asp Ser Val Ile Arg Lys Gly Ala
      50                  55                  60                
 Arg Ala Cys Glu Ile Cys Ile Thr Tyr Ile
  65                  70                



      <210> 1919
      <211> 159
      <212> PRT
      <213> Homo sapiens


      <400> 1919
 Phe Arg Pro Ile Gly Ile Ile Arg Gln Ala Leu Cys Ser Ala Asp Gly
   1               5                  10                  15    
 His Gln Arg Arg Ile Leu Thr Leu Arg Leu Gly Leu Leu Val Ile Pro
              20                  25                  30        
 Phe Leu Pro Ala Ser Asn Leu Phe Phe Arg Val Gly Phe Val Val Pro
          35                  40                  45            
 Ser Val Gly Cys Cys Val Met Leu Leu Phe Gly Val Arg Ser Leu Arg
      50                  55                  60                
 Lys His Thr Glu Lys Lys Lys Leu Ile Ala Ala Val Val Leu Gly Ile
  65                  70                  75                  80
 Leu Leu Ser Lys Met Ser Glu Arg Leu Arg Cys Ala Val Arg Gly Gly
                  85                  90                  95    
 Glu Trp Arg Ser Glu Glu Ala Val Phe Arg Gly Ala Val Ser Val Cys
             100                 105                 110        
 Pro Leu Ser Ala Glu Val Arg Cys Asn Ile Gly Arg Asn Leu Ala Ala
         115                 120                 125            
 Lys Gly Asn Gln Thr Gly Ala Ile Arg Tyr His Arg Glu Ala Val Ser
     130                 135                 140                
 Leu Asn Pro Lys Thr Lys Ser Ser Thr Arg Glu Phe Arg Pro Cys
 145                 150                 155                



      <210> 1920
      <211> 110
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(110)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 1920
 Ala Arg Ala Ala Ala Arg Ala Gly Phe Ser Ser Tyr Leu Lys Ser Leu
   1               5                  10                  15    
 Pro Asp Val Arg Lys Lys Ser Leu Pro Leu Pro Glu Lys Pro His Lys
              20                  25                  30        
 Glu Glu Asn Ser Glu Ile Val Val Trp Arg Glu Phe Asp Lys Gln Val
          35                  40                  45            
 Phe Leu Leu Asn Xaa Ser Pro Arg Arg Gln Ser Lys Leu Tyr Thr Val
      50                  55                  60                
 Asp Leu Glu Ser Gly Leu His Tyr Leu Leu Arg Val Glu Leu Ala Ala
  65                  70                  75                  80
 His Lys Ser Leu Ala Gly Ala Glu Leu Lys Thr Leu Lys Asp Phe Val
                  85                  90                  95    
 Thr Val Leu Ala Lys Leu Phe Pro Gly Arg Pro Pro Val Lys
             100                 105                 110
