                         SEQUNCE LISTING B0801.70286WO00

<110>  The Brigham And Women's Hospital, Inc.
 
<120>  Novel Functions For Decay Accelerating Factor

<130>  B0801.70286WO00

<141>  2004-08-02

<150>  US 60/492,140
<151>  2003-08-01

<160>  49    

<170>  PatentIn version 3.2

<210>  1
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring neutral amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring large amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring large amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring neutral amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring hydrophobic amino acid

<400>  1

Glu Xaa Glu Xaa Trp Xaa Arg Xaa Xaa 
1               5                   


<210>  2
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  2

Glu Val Glu Trp Trp Tyr Arg Ser Gly 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  3

Glu Val Glu Tyr Trp Tyr Arg Ser Gly 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  4

Glu Val Glu Trp Trp Tyr Arg Ser Val 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  5

Glu Met Glu His Trp Tyr Arg Ser Gly 
1               5                   


<210>  6
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  6

Glu Val Glu His Trp Tyr Arg Val Gly 
1               5                   


<210>  7
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  7

Glu Val Glu Tyr Trp Tyr Arg Val Gly 
1               5                   


<210>  8
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  8

Glu Val Glu Tyr Trp His Arg Ser Gly 
1               5                   


<210>  9
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  9

Glu Ser Glu Tyr Trp Tyr Arg Val Gly 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  10

Glu Ser Glu Trp Trp Tyr Arg Ser Gly 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  11

Glu Ser Glu His Trp Tyr Arg Ser Gly 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  12

Glu Val Glu His Trp Tyr Arg Thr Gly 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  13

Glu Val Glu His Trp Tyr Arg Phe Trp 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  14

Glu Val Glu Phe Trp Ala Arg Gly Pro 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  15

Glu Val Glu Met Trp Arg Arg Glu Gly 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  16

Glu Val Glu Arg Trp Ala Arg Ser Pro 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  17

Glu Leu Glu His Trp Leu Arg Lys Gly 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  18

Glu Val Glu His Trp Tyr Arg Thr Gly 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  19

Glu Val Glu His Trp Tyr Arg Phe Trp 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  20

Glu Val Glu Phe Trp Ala Arg Gly Pro 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  21

Glu Val Glu Met Trp Arg Arg Glu Gly 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  22

Glu Val Glu Arg Trp Ala Arg Ser Pro 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  23

Glu Ile Glu His Trp Trp Arg Ser Gly 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  24

Glu Thr Met Gly Val Pro Trp Ser Pro 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  25

Arg Glu Val Asp His Trp Leu Arg His 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  26

Ser Lys Glu Pro Ser Phe Trp Asn Gly 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  27

Glu Thr Met Gly Val Pro Trp Ser Pro 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  28

Thr Glu Ala Asp His Trp Phe Arg Ser 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  29

Ser Lys Glu Pro Ser Phe Trp Asn Gly 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  30

Glu Ile Glu His Trp Trp Arg Ser Gly 
1               5                   


<210>  31
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide


<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is deoxyThymidine


<400>  31
aauuccuggc gagaaggacu cnn                                             23


<210>  32
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is deoxyThymidine

<400>  32
nnuuaaggac cgcucuuccu gag                                             23


<210>  33
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide

<400>  33
cgtgtctcag agaccgactt                                                 20


<210>  34
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide

<400>  34
atggagggcg ccggc                                                      15


<210>  35
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  35

Ser Pro Leu Ala Gln Ala Val Arg Ser Ser Ser Arg 
1               5                   10          


<210>  36
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  36

Glu Val Glu His Trp Tyr Arg Ser Gly 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  37

Ala Val Ala His Trp Tyr Arg Ser Gly
1               5                                                            


<210>  38
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  38

Glu Val Glu His Ala Tyr Arg Ser Gly 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  39

Glu Val Glu His Trp Ala Arg Ser Gly 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  40

Glu Val Glu His Trp Tyr Ala Ser Gly 
1               5                   


<210>  41
<211>  381
<212>  PRT
<213>  Homo sapiens

<220>
<223>  peptide

<400>  41

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                85                  90                  95      


Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
            100                 105                 110         


Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 
    130                 135                 140                 


Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                165                 170                 175     


Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 
            180                 185                 190         


Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 
        195                 200                 205             


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
    210                 215                 220                 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
225                 230                 235                 240 


Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 
                245                 250                 255     


Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 
            260                 265                 270         


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
        275                 280                 285             


Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 
    290                 295                 300                 


Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
305                 310                 315                 320 


Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 
                325                 330                 335     


Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 
            340                 345                 350         


Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr 
        355                 360                 365             


Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
    370                 375                 380     


<210>  42
<211>  1357
<212>  DNA
<213>  Homo sapiens

<220>
<223>  peptide

<400>  42
gcaactcgct ccggccgctg ggcgtagctg cgactcggcg gagtcccggc ggcgcgtcct     60

tgttctaacc cggcgcgcca tgaccgtcgc gcggccgagc gtgcccgcgg cgctgcccct    120

cctcggggag ctgccccggc tgctgctgct ggtgctgttg tgcctgccgg ccgtgtgggg    180

tgactgtggc cttcccccag atgtacctaa tgcccagcca gctttggaag gccgtacaag    240

ttttcccgag gatactgtaa taacgtacaa atgtgaagaa agctttgtga aaattcctgg    300

cgagaaggac tcagtgatct gccttaaggg cagtcaatgg tcagatattg aagagttctg    360

caatcgtagc tgcgaggtgc caacaaggct aaattctgca tccctcaaac agccttatat    420

cactcagaat tattttccag tcggtactgt tgtggaatat gagtgccgtc caggttacag    480

aagagaacct tctctatcac caaaactaac ttgccttcag aatttaaaat ggtccacagc    540

agtcgaattt tgtaaaaaga aatcatgccc taatccggga gaaatacgaa atggtcagat    600

tgatgtacca ggtggcatat tatttggtgc aaccatctcc ttctcatgta acacagggta    660

caaattattt ggctcgactt ctagtttttg tcttatttca ggcagctctg tccagtggag    720

tgacccgttg ccagagtgca gagaaattta ttgtccagca ccaccacaaa ttgacaatgg    780

aataattcaa ggggaacgtg accattatgg atatagacag tctgtaacgt atgcatgtaa    840

taaaggattc accatgattg gagagcactc tatttattgt actgtgaata atgatgaagg    900

agagtggagt ggcccaccac ctgaatgcag aggaaaatct ctaacttcca aggtcccacc    960

aacagttcag aaacctacca cagtaaatgt tccaactaca gaagtctcac caacttctca   1020

gaaaaccacc acaaaaacca ccacaccaaa tgctcaagca acacggagta cacctgtttc   1080

caggacaacc aagcattttc atgaaacaac cccaaataaa ggaagtggaa ccacttcagg   1140

tactacccgt cttctatctg ggcacacgtg tttcacgttg acaggtttgc ttgggacgct   1200

agtaaccatg ggcttgctga cttagccaaa gaagagttaa gaagaaaata cacacaagta   1260

tacagactgt tcctagtttc ttagacttat ctgcatattg gataaaataa atgcaattgt   1320

gctcttcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                            1357


<210>  43
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  43

Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala Leu Glu 
1               5                   10                  15      


Gly Arg Thr 
            


<210>  44
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  44

Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Thr 
1               5                   10                  15      


Cys Leu Lys 
            


<210>  45
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  45

Ser Cys Glu Val Pro Thr Arg 
1               5           


<210>  46
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  46

Arg Glu Pro Ser Leu Ser Pro Lys 
1               5               


<210>  47
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  47

Trp Ser Thr Ala Val Glu Phe Cys Lys 
1               5                   


<210>  48
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  48

Ser Cys Pro Asn Pro Gly Glu Ile Arg 
1               5                   


<210>  49
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  49

Glu Ile Tyr Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln 
1               5                   10                  15      


Gly Glu Arg Asp His Tyr Gly Tyr Arg 
            20                  25  